### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON , D.C

. 20460

OFFICE OF CHEM I CAL SAFETY AND POLLUTION PREVENTION



### M EMO RA NDUM

D a t e: 

### I 0119 /2 015

SUB J EC T: Cyazofa mid 

### Acute and Ch r onic Aggregate Dietary (Food a nd Drinkin g Water) Ex posur e and Risk Assessments for the Sectio n 3 R eg istration Act i on on Crop Subgroup l 

### 9A and on Bulb Vegetables Crop Group 03-07.

P C Code : 

### 08565 l DP Barcodc : 

### D430735 De cis ion No.: 

### 500741, 50074 7 

### Petition No .: 

### 5E8350

, 5F8352 Ri s k A ss es s m e nt Ty p e: 

### Di etary TXR No

. : 

### NA Regi st ration No.: 

### 71512-2, 715 1 2

- 3 Re g ul a tory Action: 

### Section 3 Registration Case No .: 

### NA CAS No.: 

### 120116-88-3 40 CF R: 

### § 

### 180.60 I MRJDNo.: 

### NA

FROM:

THRO UGH:

TO: 

### Cassi Wa ll s, Ph.D., Senior Biologist

# ~ ;t__ 

# WQQJ.,.)
Risk Assessment Branch l Health Effec t s Division (HED

, 7509P)

Thurston Mort o n , Chem i st // Mohsen Sahafeyan

, Chemist

. 

## U 

# Vti--

Dietary Exposu r e Sc i ence Adv i so r y Council 

# (pEYJ

Barbara Madden/Laura No llen, Ri s k Manager Te a m 05 Risk Integration

, Minor Use, and Emerge n cy R esponse Branch ( RlM UERB) and Lindsay Roe
, Risk Manager Fu n g i cide Branch Registration Divi sio n (7505 P )

E x ec uti ve S ummary



### Acute a nd chronic aggregate dietary (food and drinking water) exposure and risk assessments

were conducted using th e Dietary Expos ure Eval uation Mode l software w i th the Food Commodity Intake Database (DEEM-FCID) Ver s ion 3.16. Thi s software u ses 2003-2008 food consumption d a ta from the U.S. Departm e nt of Agriculture's (US DA 's) National Health and Nu triti on Examina tion S urv ey, What We Ea t in America

, (NHANES / WWEIA). T h e analyses

were conducted in support of a human-h ea lth ri sk assessment for the propo se d Section 3 u ses of

Page I of25Cyazofam id Dietary Expos ur e and Risk Assessment DP Number: 430735



### cy azofamid o n Crop Subgroup l 9A and on Bulb V egetab le s Crop Group 03-07. This memorandum was reviewed by two p ee r reviewers of the DE S AC on I 0

- 28-20 I 5

, per D ES AC SO P2 0 12.I.

U nr efi n ed ac ut e and chron ic dietary exposu r e analyses were p erfo rm e d for the general U.S. population and various population subgroups. Fo r the b o th dietary analyses

, tolerance level

r es idu es and l 00% c rop treated ass umption s w ere u se d. D EEM default and e mpiri ca l processin g factors wer e u se d t o modify th e tolerance va lues

. The assessments in corpo r ate d the grou nd

wa ter ( PRZM-GW ) drinking water estimates from app li cation of cy azofam id to ornamenta l s. The es timat e d drinking water concentrations (E D WCs) u se d in the ac ut e and c hr onic

assessments were 22 4 ppb and 2 11 ppb

, respectiv e ly.

An acute di e tary ( food 

## + drinking water) exposure assessment was perform e d for fema l es 13

- 49
years old only, since an ac ute endpoint o f concern w as n ot identified for th e general population. Acute dietar y risk es timates are not of co nc ern for fema l es 13-49 years old o nly which ha s a%

ac ut e P o pulation- Adj usted Do se (a P A D ) of 3. 1 %

.

Chronic di e t a r y ri s k estimates are not of concern for the ge neral U

. S. popu l ation or any of the

ot her population subg roup s. The subgroup with th e high est ri s k es tim ate is c hildr e n 1

- 2 years

o ld with a% chronic P opulation-Adjusted D ose (cPA D ) of2.0%. The % cPAD fo r the ge neral U.S. p o pulati o n i s 

### l. l %.



### I. 

### Introdu ct ion

Dietary risk assess m e nt incorporates b ot h exposure and toxic it y of a g i ve n pesticide. For acut e and c hr o ni c assessments, the ri s k is expressed as a p e rc e ntage of a m ax imum acceptable dose ( i.e.

, th e d ose tha t HED ha s concluded w ill r es ult in no unreasonable a d ve r se health effec t s). This do se i s r ef err e d to as the population

- adju s ted do se ( PAD ). The P A D i s eq ui va l e nt t o the point of depa1ture ( POD ) di v id e d by the required uncertainty o r sa fety factors.

For acute and non- ca nc e r chronic exposures , HED i s conc e rn e d when es tim a t ed di e tary ri s k

excee d s 100 % of the PAD. Re fer enc es that d i scuss the acute and chronic ri sk assessme nt s in

more detail are available on th e EPA/pesticid es web s it e: " Ava i lab l e Information on Assess in g Expos ure from P estic id es, A Use r ' s Gui de ," 2 l

- J UN -20 00, web link : http: // wwvv.reg ul ations

. gov /# !d oc um e ntDet a il:D = E PA-HQ-OPP- 2007

- 0780-000 I ; o r sec SOP 99 .6 (20

- AUG -19 99)

.

Th e m ost r ece nt di etary ri s k assessment for cyazofa mid was conducted by Nancy Dodd ( 4 / 30 / 1 2, DP3 972 14 ).



### II

. Residue Information

Cyazofam id i s currently registered for foo d u se und er FIFRA sec. 3 o n ba s il

, beans (s uc culent), Brassica (subgroup s A and B )

, carrot roots , hops

, leaf y g r ee n s (s ubgroup 4A ), turnip greens,

cuc urbit s (grou p 9), fruitin g vegetab l es (group 8-10 ), and tub erous and corm (s ub gro up 1 C)

.

P age 2 o f25Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 3 of 25 

### Permanent tolerances for these commodities are established in 40 CFR §180.601at levels ranging from 0.02 ppm on potato to 90 ppm on dried basil . A tolerance with regional registration is established on grape at 1.5 ppm. No tolerances have been established on livestock commodities. Compliance with all tolerances specified in 40 CFR §180.601 is to be determined by measuring only the sum of cyazofamid and its metabolite, 4

- chloro

- 5

- p

- tolylimidazole

- 2

- carbonitrile (CCIM), calculated as the stoichiometric equivalent of cyazofamid.

The nature of cyazofamid residues in plants is adequately understood

. The HED Metabolism Assessment Review Committee (MARC) determined in a meeting on 2/18/04 that the residues of concern for risk assessment are parent and CCIM in plants, parent only in rotational crops, and parent, CCIM, CCIM

- AM, and CTCA in water. For livestock commodities, the proposed and established uses fall under 40 CFR §180.6(a)(3), i.e., there is no reasonable expectation of finite residues in livestock commodities.

The conservative acute and chronic analyses assumed that cyazofamid residues are present in/on all proposed and registered food commodities at tolerance levels and that 100% of all commodities are treated. Adequate processing data are available for currently registered commodities. The results of these studies indicate that combined residues of cyazofamid and CCIM in processed commodities are not expected to exceed the tolerances on the raw agricultural commodities. Therefore, processing factors were set to 1x, except that default processing factors were used for dried tomatoes and tomato juice since those commodit ies are not required to be analyzed in processing studies

. The food residue data used in the acute and chronic analyses are summarized i n Table 1 below

.
Table 1. Residue Data Used in the Acute and Chronic Dietary Analyses for Cyazofamid Commodity Exist ing Tolerance (ppm) Recommended

Tolerance (ppm) Processing

Factors

Basil, fresh leaves 90

NA 2 

### NA 2 

### Basil, dried leaves 90 Bean, succulent 0.5 Bean, succulent, shelled 0.08 Brassica, head and stem, subgroup 5A 1.2 Brassica, leafy greens, subgroup 5B 12 Carrot, roots 0.09 Hop dried cones 10.0 Leafy greens

, subgroup 4A 10 Turnip greens 12.0 Vegetable, cucurbit, group 9 0.10 Vegetable, tuberous and corm, subgroup 1C 0.02

Vegetable, fruiting, group 8

- 10 0.9 Dried tomato 14.3 Tomato juice 1.5 Grapes 1.5 Bulb vegetables, group 3

- 07 NA 2 

### 2.0 NA 2 

### Herb subgroup 19A 2.0

2 NA = not applicable.Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 4 of 25 

### The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, and 2010 . In general, pesticide residues would not be expected to be found in fish unless the pesticide bio accumulates or has an aquatic use. To determine whether or not residues are present in fish, HED now routinely check s PDP monitoring data regardless of the pesticide’s uses and physicochemical properties. H owever, PDP did not analyze catfish samples for cyazofamid . As a result, residues in fish were not included in the assessment

.

I I I. Percent Crop Treated Information

100 percent crop t reated estimates were used in the acute and chronic dietary risk assessment s.
IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (EFED) in the following me morandum: “ Estimated Drinking Water Concentrations of Cyazofamid and its Degradates of Concern CCIM, CCIM

- AM and CTCA, for Use in Human Health Risk Assessment: Petition s for the Use on Herb ( Subgroup 19A ) , Greenhouse Tomato

, Greenhouse Pepper, and Bulb Veg etables ( Group 03

- 07 ) ” (D426776

, J. Meléndez , 10/06/15 ) and incorporated directly into this dietary assessment. Water residues were incorporated in the DEEM

- FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.”

As shown in Table 2 below, the acute value of 224 ppb and the non

- cancer chronic value of 211 ppb were the EDWCs which were directly entered into the exposure model to assess the contributions from drinking water. These EDWCs were modeled using PRZM

- GW ( Pesticide Root Zone Model for Groundwater) for residues in groundwater from use on ornamentals, which had the highest seasonal rates among the proposed and registered uses. Acute and chronic EDWCs in surface water as modeled by PRZM

- EXAMS ( Pesticide Root Zone Model/Exposure Analysis Modeling System ) were lower. It should be noted that, given that groundwater exposure occurs usually after a long period of time, the terminal degradate of cyazofamid (CTCA) was modeled in lieu of the parent cyazofamid plus ot her degradates . It was assumed 100% CTCA formation from the parent compound.

Table 2. Maximum Estimated Drinking Water Concentrations for Cyazofamid, CCIM, CCIM

- AM and CTCA. Maximum EDWCs Are Based on the Use on Turf and Ornamentals Drinking Water S ource (Model Used) Use (rate modeled per year) Estimated Drinking Water Concentration (EDWC) (ppb) (Species) Groundwater (PRZM

- GW) Ornamentals (3.12 lb a.i./A/yr) Acute (CTCA) 224 1 Chronic (CTCA) 211 1

Surface water (PRZM/EXAMS) Turf & Ornamentals (3.0 & 3.12 lb a.i./A/yr, respectively) Acute (cyazofamid, CCIM, CCIM

- AM) 38.2 2 Chronic (CTCA) 133.5 2 Cancer/Chronic (CTCA) 77.3 2 1. For groundwater, acute and chronic exposure is based on modeling the degradate CTCA

. 2. For surface water, acute exposure is based on modeling of the parent cyazofamid plus the degradates CCIM and CCIM

- AM. Chronic exposure is based on modeling of the degradate CTCA.



### The drinking water model s and t heir description s are available at the EPA i nternet site: http://www.epa.gov/oppefed1/models/water/

.Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 5 of 25 

### V. DEEM

- FCID Program and Consumption Information

Cyazofamid acute and chronic dietary exposure assessments were conducted using the DEEM

FCID, Version 3.16 , which incorporates 2003

- 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over t wo non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commodities (e.g.

, apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe trans lation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups . However , for acute exposure assessment , consumption data are retained as in dividual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the g eneral U.S. population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 49, females 13

- 49, and adults 50

- 99 years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food for m is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is pe rformed for each population subgroup.

For an acute exposure assessment, individual one

- day food consumption data are used on an individual

- by

- individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estima te and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is
expres sed as a percentage of the aPAD on both a user (i.e., only those who reported eating relevant commodities/food forms) and a per

- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED po licy, per capita exposure and risk are reported for a nalyses performed at all levels of refinement . However, for deterministic assessments , any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the r isk assessment.

VI. Toxicological Information

Following repeated administration in more than one species, cyazofamid seems to have mild or low toxicity. The kidney appeared to be affected the most. Skin lesions were observed in male mice only, likely due to systemic allergy . In dogs, there were no major toxicity findings. In the acute neurotoxicity study, there were no indications of treatment

- related adverse neurotoxicity.

The pre

- and post

- natal toxicology database for cyazofamid includes rat and rabbit developmental toxicity studies and a two

- generation reproduction toxicity study in rats. ThereCyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 6 of 25 

### was some evidence of increased susceptibility following in utero exposure to rats in the prenatal developmental toxicity study; the increased incidence o f bent ribs in the high

- dose fetuses was considered adverse and was used for setting th e developmental NOAEL/LOAEL (no observed adverse effect level/lowe st observed adverse effect level). HED considers this approach conservative and highly protective beca use bent ribs are a reversible developmental anoma ly rather than a malformation.

Cyazofamid is classified as “not likely to be carcinogenic to humans” based on the lack of evidence of carcinogenicity in both the rat and the mouse studies. Additionally, c yazofamid does not appear to be mutagenic , based on several negative in vivo and in vitro studies.

The HED cyazofamid risk assessment team has recommended that the FQPA Safety Factor be reduced to 1X (DP# D356837, N. Tsaur, 20

- MAY

- 2009; DP# D370671, N. Ts aur, 7

- APR

- 2010). In brief, the toxicology database is adequate for the purpose of characterization of potential pre

and postnatal risks to infants and children. The concern is low for the quantitative susceptibility seen in the rat developmental toxici ty study and there are no residual uncertainties. There were no indications of pre

- and/or postnatal toxicity and no residual uncertainties from the rabbit developmental study or the rat two

- generation reproduction study. Although a subchronic neurotoxici ty study is not available, the acute neurotoxicity study showed no neurotoxic effects. Neurotoxicity and immunotoxicity were not demonstrated in the available studies. The dietary (food and water) and residential exposure assessments are conservative and are not likely to underestimate the potential exposures.

Table 3. Summary of Toxicological Doses and Endpoints for Cyazofamid for Use in Dietary

Exposure Risk Assessments. Exposure/ Scenario Point of

Departure (PoD) Uncertainty/F

QPA Safety Factors RfD, PAD,

Level of Concern Study and Toxicological Effects

Acute Dietary (General Population, including Infants and Children) No adverse effects were observed which could be attributed to a single

- dose exposure for the

general population.

Acute Dietary (Females 13

- 49 years of age) NOAEL =

100 mg/kg/day UF A = 10X

UF H = 10X FQPA SF = 1X Acute RfD = 1.0

mg/kg/day

aPAD = 1.0 mg/kg/day Rat Prenatal Developmental Toxicity

(MRID 45408933) LOAEL = 1,000 mg/kg/day based on developmental toxicity findings of inc reased incidence of bent ribs.

Chronic Dietary (All Populations) NOAEL=

94.8 mg/kg/day UF A = 10X

UF H = 10X FQPA SF = 1X Chronic RfD =

0.95 mg/kg/day

cPAD = 0.95 mg/kg/day 18

- Month Mouse Oral Carcinogenicity

(MRID 45408932) LOAEL = 985 mg/kg/day based on increased skin lesions.

Cancer (oral, dermal, inhalation) Classification: “Not likely to be Carcinogenic to Humans” based on the absence of

significant tumor increases in two adequate rodent carcinogenicity studies. Point of Departure (POD) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no obs erved adverse effect level. LOAEL = lowest observed adverse effect level. UF =Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 7 of 25 uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose. N/A = not applicable.



### VII. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM

- FCIDTM analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 4 are for the general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50+ years old.

Results of Acute Dietary (Food and Drinking Water) Exposure Analysis

An acute dietary (food + drinking water) exposure assessment was performed for females 13

- 49 years old only, since an acute endpoint of concern was not identified for the general population.

The acute dietary (food and drinking water) exposure assessment i s conservative, i.e., based on the assumption that residues in all crops are at the tolerance levels and that 100% of the crops are treated (100% CT). The acute dietary risk assessment shows that the acute dietary risk estimates are below HED’s level of c oncern (i.e.

, <100% of the acute population adjusted dose (cPAD ) ). The acute dietary risk estimate for females 13

- 49 years old at the 95 th 

### percentile of exposure was 3.1 % of the a PAD

. The results of the acute dietary exposure analysis are reported in Tab le 4 below.

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The chronic dietary (food and drinking water) exposure assessment is conservative, i.e., based on the assumption that residues in all crops are at the tolerance levels and that 100% of the crops are treated (100% CT). The chronic dietary risk assessment shows that the chronic dietary risk estimates are below HED’s level of concern (i.e.

, <100% of the chronic populat ion adjusted dose (cPAD ) ). For the general U.S. population

, the exposure for food and drinking water utilized 1 .1 % of the cPAD. The chronic dietary risk estimate for the highest reported exposed population subgroup , children (1

- 2 years old), was 2.0 % of the cPAD. The results of the chronic dietary exposure analysis are reported in Table 4 below.Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 8 of 25 Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Cyazofamid.

Population Subgroup Acute Dietary (95 th Percentile) Chronic Dietary Cancer

Dietary Exposure (mg/kg/day) % aPAD* Dietary Exposure (mg/kg/day) % cPAD* Dietary Exposure (mg/kg/day) Risk

General U.S. Population

NA 1 NA 0.010631 1 .1

N/A N/A All Infants (< 1 year old) 0.015810 1. 7

Children 1

- 2 years old 0.018609 2.0

Children 3

- 5 years old 0.015997 1. 7

Children 6

- 12 years old 0.010164 1 .1

Youth 13

- 19 years old 0.007809 <1%

Adults 20

- 49 years old 0.010452 1.1

Adults 50+ years old 0.010256 1.1

Females 13

- 49 years old 0.031118 3.1 0.010436 1.1

1 NA = Not Applicable



### VIII. Characterization of Inputs/Outputs

The acute and chronic dietary exposure and risk estimates are conservative since they assume that 100% of the crops are treated with cyazofamid and that residues are present at tolerance levels. In addition, EDWCs w ere based on screening level estim ates generated by the PRZM

GW model. Dietary exposure estimates could be refined through the use of anticipated residues and percent crop treated data, as well as refined estimated drinking water concentrations. However, since estimated exposures and risks us ing conservative assumptions are well below the Agency ’s level of concern, such refinement is not warranted.

IX. Conclusions

These conservative dietary exposure analyses using DEEM

- FCIDTM indicate that acute and chronic dietary exposures to cyazofamid fr om food and drinking water are well below the Agency ’s level of concern. Both assessments were conservative, i.e., the assessments assumed that residues in all crops were at tolerance levels and that 100% of the crops were treated. An acute endpoint was not identified for the general U.S. population. The estimated acute exposure of females 13

- 49 years old, the only population subgroup of concern for acute exposure, represents 3.1 % of the aPAD at the 95 th 

### percentile of exposure. Estimated chronic dietary
exposures are 1.1 % of the cPAD for the general U.S. population and 2.0 % of the cPAD for the highest reported exposed population subgroup , children (1

- 2 years old)

.Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 9 of 25 

### X. List of Attachments

• Acute Food plus Water Residue Input File.

• Acute Food plus Water Results File.

• Acute Food Only Residue Input File.

• Acute Food Only Results File

• Chronic Food plus Water Residue Input File.

• Chronic Food plus Water Results File.

• Chronic Food Only Residue Input File.

• Chronic Food Only Results File.Page 10 of 25 

### Acute Food plus Water Residue Input File

Filename: C: \ Users \ cwalls \ Documents \ Cassi \ HED \ cyazofamid \ New Use 2015 \ dietary \ ACUTE CYAZOFAMID FOOD+WATER 101015.R08 Chemical: cyazofamid RfD(Chronic): .95 mg/kg bw/day NOEL(Chronic): 94.8 mg/kg bw/day RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day Date created/last modified: 10

- 07

- 2015/10:42:04 Program ver. 3.16, 03

- 08

- d Comment: Drinking water from PRZM

- GW

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101078000 1AB Carrot 0.090000 1.000 1.000 0101078001 1AB Carrot

- babyfood 0.090000 1.000 1.000 0101079000 1AB Carrot, juice 0.090000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.020000 1.000 1.000 0103015001 1CD Arrowroot, flour

- babyfood 0.020000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 0103082000 1CD Cassava 0.020000 1.000 1.000 0103082001 1CD Cassav a
- babyfood 0.020000 1.000 1.000 0103139000 1CD Dasheen, corm 0.020000 1.000 1.000 0103166000 1CD Ginger 0.020000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.020000 1.000 1.000 0103167000 1CD Ginger, dried 0.020000 1.000 1.000 0103296000 1C Potato, chips 0.020000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.020 000 1.000 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.020000 1.000 1.000 0103298000 1C Potato, flour 0.020000 1.000 1.000 0103298001 1C Potato, flour

- babyfood 0.020000 1.000 1.000 0103 299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.020000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 0103300001 1C Potato, tuber , w/o peel

- babyfood 0.020000 1.000 1.000 0103366000 1CD Sweet potato 0.020000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 0.020000 1.000 1.000 0103371000 1CD Tanier, corm 0.0 20000 1.000 1.000 0103387000 1CD Turmeric 0.020000 1.000 1.000 0103406000 1CD Yam, true 0.020000 1.000 1.000 0103407000 1CD Yam bean 0.020000 1.000 1.000 03 01165000 3A Garlic, bulb 2.000000 1.000 1.000 0301165001 3A Garlic, bulb

- babyfood 2.000000 1.000 1.000 0301237000 3A Onion, bulb 2.000000 1.000 1.000 0301237001 3A Onion, bulb

- babyfood 2.000000 1.000 1.000 0301238000 3A Onion, bulb, dried 2.000000 9.000 1.000 0301238001 3A Onion, bulb, dried

- babyfood 2.000000 9.000 1.000 0301338000 3A Shallot, bulb 2 .000000 1.000 1.000 0302103000 3B Chive, fresh leaves 2.000000 1.000 1.000 0302198000 3B Leek 2.000000 1.000 1.000 0302239000 3B Onion, green 2.000000 1.000 1.000 0302338500 3B Shallot, fresh leaves 2.000000 1.000 1.000 0401005000 4A Amaranth, leafy 10.000000 1.000 1.000 0401018000 4A Arugula 10.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 10.000000 1.000 1.000 0401133000 4A Cress, garden 10.000000 1.000 1.000 0401134000 4A Cress, upland 10.000000 1.000 1.000 0401138000 4A Dandelion , leaves 10.000000 1.000 1.000 0401150000 4A Endive 10.000000 1.000 1.000 0401204000 4A Lettuce, head 10.000000 1.000 1.000 0401205000 4A Lettuce, leaf 10.000000 1.000 1.000 0401248000 4A Parsley, leaves 10.000000 1.000 1.000 0401313000 4A Radicchio 10.000000 1.000 1.000Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 11 of 25 0401355000 4A Spinach 10.000000 1.000 1.000 0401355001 4A Spinach

- babyfood 10.000000 1.000 1.000 0501061000 5A Broccoli 1.200000 1.000 1.000 0501061001 5A Broccoli

- babyfood 1.200000 1.000 1.000 0501062000 5A Broccol i, Chinese 1.200000 1.000 1.000 0501064000 5A Brussels sprouts 1.200000 1.000 1.000 0501069000 5A Cabbage 1.200000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 0501083000 5A Cauliflower 1.200000 1.000 1.000 0501196000 5A Kohlrabi 1.200000 1.000 1.00 0 0502063000 5B Broccoli raab 12.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 0502117000 5B Collards 12.000000 1.000 1.000 0502194000 5B Kale 12.000000 1.000 1.000 0502229000 5B Mustard greens 12.000000 1.000 1.000 0502318000 5B Rape greens 12.000000 1.000 1.000 0502389000 5B Turnip, greens 12.000000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.500000 1.000 1.000 0601043001 6A Bean, snap, succulent

- babyfood 0.500000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.080000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.080000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.080000 1.000 1.000 0801374000 8A Tomatillo 0.900000 1.000 1.000 0801375000 8A T omato 0.900000 1.000 1.000 0801375001 8A Tomato

- babyfood 0.900000 1.000 1.000 0801376000 8A Tomato, paste 0.900000 1.000 1.000 0801376001 8A Tomato, paste

- babyfood 0.900000 1.000 1.000 0801377000 8A Tomato, puree 0.900000 1.000 1.000 0801377001 8A Tomato, puree

- babyfood 0.900000 1.000 1.000 0801378000 8A Tomato, dried 0.900000 14.300 1.000 0801378001 8A Tomato, dried

- babyfood 0.900000 14.300 1.000 0801379000 8A Tomato, juice 0.900000 1.500 1.000 0801380000 8A Tomato, Tree 0.900000 1.000 1.000 0802148000 8BC Eggplant 0.900000 1.000 1.000 0802234000 8BC Okra 0.900000 1.000 1.000 0802270000 8B Pepper, bell 0.900000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 0.900000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.900000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 0.900000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.900000 1.0 00 1.000 0802272001 8BC Pepper, nonbell

- babyfood 0.900000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.900000 1.000 1.000 0901075000 9A Cantaloupe 0.100000 1.000 1.000 0901187000 9A Honeydew melon 0.100000 1.000 1.000 0901399000 9A Watermelon 0.100000 1.000 1.000 0901400000 9A Watermelon, juice 0.100000 1.000 1.000 0902021000 9B Balsam pear 0.100000 1.000 1.000 0902088000 9B Chayote, fruit 0.100000 1.000 1.000 0902102000 9B Chinese waxgourd 0.100000 1.000 1.000 0902135000 9B Cucumber 0.100000 1.000 1.000 0902308000 9B Pumpkin 0.100000 1.000 1.000 0902309000 9B Pumpkin, seed 0.100000 1.000 1.000 0902356000 9B Squash, summer 0.100000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.100000 1.000 1.000 0902357000 9B Squash, winter 0.100000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.100000 1.000 1.000 1304175000 13D Grape 1.500000 1.000 1.000 1304176000 13D Grape, juice 1.500000 1.000 1.000 1304176001 13D Grape, juice

- babyfood 1.500000 1.000 1.000 1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 1901028000 19A Basil, fresh leaves 90.000000 1.000 1.000 1901028001 19A Basil, fresh leaves

- babyfood 90.000000 1.000 1.000Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 12 of 25 1901029000 19A Basil, dried leaves 90.000000 1.000 1.000 1901029001 19A Basil, dried leaves

- babyfood 90.000000 1.000 1.000 1901102500 19A Chive, dried leaves 90.000000 1.000 1.000 1901118000 19A Cilantro, leaves 90.000000 1.000 1.00 0 1901118001 19A Cilantro, leaves

- babyfood 90.000000 1.000 1.000 1901144000 19A Dillweed 90.000000 1.000 1.000 1901184000 19A Herbs, other 90.000000 1.000 1.000 1901184001 19A Herbs , other

- babyfood 90.000000 1.000 1.000 1901202000 19A Lemongrass 90.000000 1.000 1.000 1901220000 19A Marjoram 90.000000 1.000 1.000 1901220001 19A Marjoram

- babyfood 90.000000 1.000 1.000 1901249000 19A Parsley, dried leaves 90.000000 1.000 1.000 1901249001 19A Parsley, dried leaves

- babyfood 90.000000 1.000 1.000 1901334000 19A Savory 90.000000 1.000 1.000 8601000000 86A Water, direct, all sources 0.224000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.224000 1.000 1.000 9500177000 O Grape, leaves 1.500000 1.000 1.000 9500178000 O Grape, raisin 1.500000 1.000 1.000 9500188000 O Hop 10.000000 1.000 1.000Page 13 of 25 

### Acute Food plus Water Results File

US EPA Ver. 3.18, 03

- 08

- d
DEEM

- FCID ACUTE Analysis for CYAZOFAMID NHANES 2003

- 2008 2

- Day Residue file: ACUTE CYAZOFAMID FOOD+WATER 101015.R08 Adjustment factor #2 NOT used. Analysis Date: 10

- 14

- 2015/11:17:23 Residue file dated: 10

- 14

- 2015/10:59:39 NOEL (Acute) = 100.000000 mg/kg body

- wt/day RAC/FF intake summed over 24 hours Run Comment: "Drinking water from PRZM

- GW"

===============================================================================

Summary calc ulations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Female 13

- 49: 0.031118 3.11 3213 0.048160 4.82 2076 0.077492 7.75 1290Page 14 of 25 

### Acute Food Only Residue Input File

Filename: C: \ Users \ cwalls \ Documents \ Cassi \ HED \ cyazofamid \ New Use 2015 \ dietary \ ACUTE CYAZOFAMID FOOD only 101015.R08 Chemical: cyazofamid RfD(Chronic): .95 mg/kg bw/day NOEL(Chronic): 94.8 mg/kg bw/day RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day Date created/last modified: 10

- 07

- 2015/10:44:20 Program ver. 3.16, 03

- 08

- d Comment: Drinking water from PRZM

- GW

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0101078000 1AB Carrot 0.090000 1.000 1.000 0101078001 1AB Carrot

- babyfood 0.090000 1.000 1.000 0101079000 1AB Carrot, juice 0.090000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.020000 1.000 1.000 0103015001 1CD Arrowroot, flour

- babyfood 0.020000 1.000 1.000 0103017000 1CD A rtichoke, Jerusalem 0.020000 1.000 1.000 0103082000 1CD Cassava 0.020000 1.000 1.000 0103082001 1CD Cassava

- babyfood 0.020000 1.000 1.000 0103139000 1CD Dasheen, corm 0.020000 1.000 1.000 0103166000 1CD Ginger 0.020000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.020000 1.000 1.000 0103167000 1CD Ginger, dried 0.020000 1.000 1.000 0103296000 1C Potato, chips 0.020000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.020000 1.000 1.000 0103298000 1C Potato, flour 0.020000 1.000 1.000 0103298001 1C Potato, flour

- babyfood 0.020000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 0103299001 1C Potato, t uber, w/peel

- babyfood 0.020000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.020000 1.000 1.000 0103366000 1CD Sweet potato 0.020000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 0.020000 1.000 1.000 0103371000 1CD Tanier, corm 0.020000 1.000 1.000 0103387000 1CD Turmeric 0.020000 1.000 1.000 0103406000 1CD Yam, true 0.020000 1.000 1.000 0103407000 1CD Yam bean 0.020000 1.000 1.000 0301165000 3A Garlic, bulb 2.000000 1.000 1.000 0301165001 3A Garlic, bulb

- babyfood 2.000000 1.000 1.000 0301237000 3A Onion, bulb 2.000000 1.000 1.000 0301237001 3A Onion, bulb

- babyfood 2.000000 1.000 1.000 0301238000 3A Onion, bulb, dried 2.000000 9.000 1.000 0301238001 3A Onion, bulb, dried

- babyfood 2.000000 9.000 1.000 0301338000 3A Shallot, bulb 2.000000 1.000 1.000 0302103000 3B Chive, fresh leaves 2.000000 1.000 1.00 0 0302198000 3B Leek 2.000000 1.000 1.000 0302239000 3B Onion, green 2.000000 1.000 1.000 0302338500 3B Shallot, fresh leaves 2.000000 1.000 1.000 0401005000 4A Amara nth, leafy 10.000000 1.000 1.000 0401018000 4A Arugula 10.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 10.000000 1.000 1.000 0401133000 4A Cress, garden 10.000000 1.000 1.000 0401134000 4A Cress, upland 10.000000 1.000 1.000 0401138000 4A Dandelion, leaves 10.000000 1.000 1.000 0401150000 4A Endive 10.000000 1.000 1.000 0401204000 4A Lettuce, head 10.000000 1.000 1.000 0401205000 4A Lettuce, leaf 10.000000 1.000 1.000 0401248000 4A Parsley, leaves 10.000000 1.000 1.000 0401313000 4A R adicchio 10.000000 1.000 1.000Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 15 of 25 0401355000 4A Spinach 10.000000 1.000 1.000 0401355001 4A Spinach

- babyfood 10.000000 1.000 1.000 0501061000 5A Broccoli 1.200000 1.000 1.000 0501061001 5A Broccoli

- babyfood 1.200000 1.000 1.000 0501062000 5A Broccoli, Chinese 1.200000 1.000 1.000 0501064000 5A Brussels sprouts 1.200000 1.000 1.000 0501069000 5A Cabbage 1.200000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 0501083000 5A Cauliflower 1.200000 1.000 1.000 0501196000 5A Kohlrabi 1.200000 1.000 1.000 0502063000 5B Broccoli raab 12.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok ch oy 12.000000 1.000 1.000 0502117000 5B Collards 12.000000 1.000 1.000 0502194000 5B Kale 12.000000 1.000 1.000 0502229000 5B Mustard greens 12.000000 1.0 00 1.000 0502318000 5B Rape greens 12.000000 1.000 1.000 0502389000 5B Turnip, greens 12.000000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.500000 1.000 1.000 0601043001 6A Bean, snap, succulent

- babyfood 0.500000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.080000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.080000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.080000 1.000 1.000 0801374000 8A Tomatillo 0.900000 1.000 1.000 0801375000 8A Tomato 0.900000 1.000 1.000 0801375001 8A Tomato

- babyfood 0.900000 1.000 1.000 0801376000 8A Tomato, paste 0.900000 1.000 1.000 0801376001 8A Tomato, paste

- babyfood 0.900000 1.000 1.000 0801377000 8A Tomato, puree 0.900000 1.000 1.000 0801377001 8A Tomato, puree

- babyfood 0.900000 1.000 1.000 0801378000 8A Tomato, dried 0.900000 14.300 1.000 0801378001 8A Tomato, dried

- babyfood 0.900000 14.300 1.000 0801379000 8A Tomato, juice 0.900000 1.500 1.000 0801380000 8A Tomato, Tree 0.900000 1.000 1.000 0802148000 8BC Eggplant 0.900000 1.000 1.000 0802234000 8BC Okra 0.900000 1.000 1.000 0802270000 8B Pepper, bell 0.900000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 0.900000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.900000 1.000 1.000 08022710 01 8B Pepper, bell, dried

- babyfood 0.900000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.900000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 0.900000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.900000 1.000 1.000 0901075000 9A Cantaloupe 0.100000 1.000 1.000 0901187000 9A Honeydew melon 0.100000 1.000 1.000 0901399000 9A Watermelon 0.10000 0 1.000 1.000 0901400000 9A Watermelon, juice 0.100000 1.000 1.000 0902021000 9B Balsam pear 0.100000 1.000 1.000 0902088000 9B Chayote, fruit 0.100000 1.000 1.000 090210 2000 9B Chinese waxgourd 0.100000 1.000 1.000 0902135000 9B Cucumber 0.100000 1.000 1.000 0902308000 9B Pumpkin 0.100000 1.000 1.000 0902309000 9B Pumpkin, seed 0.100000 1.000 1.000 0902356000 9B Squash, summer 0.100000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.100000 1.000 1.000 0902357000 9B Squash, winter 0.100000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.100000 1.000 1.000 1304175000 13D Grape 1.500000 1.000 1.000 1304176000 13D Grape, ju ice 1.500000 1.000 1.000 1304176001 13D Grape, juice

- babyfood 1.500000 1.000 1.000 1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 1901028000 19A Basil, fresh leaves 90.000000 1.000 1.000 1901028001 19A Basil, fresh leaves

- babyfood 90.000000 1.000 1.000Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 16 of 25 1901029000 19A Basil, dried leaves 90.000000 1.000 1.000 1901029001 19A Basil, dried leaves

- babyfood 90.000000 1.000 1.000 1901102500 19A Chive, dried leaves 90.000000 1.000 1.000 1901118000 19A Cilantro, leaves 90.000000 1.000 1.000 1901118001 19A Cilantro, leaves

- babyfood 90.000000 1.000 1.000 1901144000 19A Dillwee d 90.000000 1.000 1.000 1901184000 19A Herbs, other 90.000000 1.000 1.000 1901184001 19A Herbs, other

- babyfood 90.000000 1.000 1.000 1901202000 19A Lemongrass 90.000000 1.000 1.000 1901220000 19A Marjoram 90.000000 1.000 1.000 1901220001 19A Marjoram

- babyfood 90.000000 1.000 1.000 1901249000 19A Parsley, dried leaves 90.000000 1.000 1.00 0 1901249001 19A Parsley, dried leaves

- babyfood 90.000000 1.000 1.000 1901334000 19A Savory 90.000000 1.000 1.000 9500177000 O Grape, leaves 1.500000 1.000 1.000 9500178000 O Grape , raisin 1.500000 1.000 1.000 9500188000 O Hop 10.000000 1.000 1.000Page 17 of 25 

### Acute Food Only Results

US EPA Ver. 3.18, 03

- 08

- d
DEEM

- FCID ACUTE Analysis for CYAZOFAMID NHANES 2003

- 2008 2

- Day Residue file: ACUTE CYAZOFAMID FOOD only 101015.R08 Adjustment factor #2 NOT used. Analysis Date: 10

- 14

- 2015/11:03:59 Residue file dated: 10

- 14

- 2015/10:58:41 NOEL (Acute) = 100.000000 mg/kg body

- wt/day RAC/FF intake summed over 24 hours Run Comment: "Drinking water from PRZM

- GW"

===============================================================================

Summary calculations

-- per capita:

--- 95th Percentile

---- --- 99th Percentile

---- --- 99.9th Percentile

---- Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- Female 13

- 49: 0.023040 2.30 43 40 0.041042 4.10 2436 0.068463 6.85 1460Page 18 of 25 

### Chronic Food plus Water Residue Input File

Filename: C: \ Users \ cwalls \ Documents \ Cassi \ HED \ cyazofamid \ New Use 2015 \ dietary \ CHRONIC CYAZOFAMID FOOD+WATER 101015.R08 Chemical: cyazofamid RfD(Chronic): .95 mg/kg bw/day NOEL(Chronic): 94.8 mg/kg bw/day RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day Date created/last modified: 10

- 07

- 2015/10:39:01 Program ver. 3.16, 03

- 08

- d Comment: Drinking water from PRZM

- GW

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- -- -- ------------------------------- ---------- ------ ------ ------- 0101078000 1AB Carrot 0.090000 1.000 1.000 0101078001 1AB Carrot

- babyfood 0.090000 1.000 1.000 0101079000 1AB Carrot, juice 0.090000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.020000 1.000 1.000 0103015001 1CD Arrowroot, flour

- babyfood 0.020000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.020 000 1.000 1.000 0103082000 1CD Cassava 0.020000 1.000 1.000 0103082001 1CD Cassava

- babyfood 0.020000 1.000 1.000 0103139000 1CD Dasheen, corm 0.020000 1.000 1.000 0103 166000 1CD Ginger 0.020000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.020000 1.000 1.000 0103167000 1CD Ginger, dried 0.020000 1.000 1.000 0103296000 1C Potato, chips 0.020000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.020000 1.000 1.000 0103298000 1C Potato, flour 0.0 20000 1.000 1.000 0103298001 1C Potato, flour

- babyfood 0.020000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.020000 1.000 1.000 01 03300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.020000 1.000 1.000 0103366000 1CD Sweet potato 0.020000 1.000 1.000 0103366001 1CD Sweet potat o
- babyfood 0.020000 1.000 1.000 0103371000 1CD Tanier, corm 0.020000 1.000 1.000 0103387000 1CD Turmeric 0.020000 1.000 1.000 0103406000 1CD Yam , true 0.020000 1.000 1.000 0103407000 1CD Yam bean 0.020000 1.000 1.000 0301165000 3A Garlic, bulb 2.000000 1.000 1.000 0301165001 3A Garlic, bulb

- babyfood 2.000000 1.000 1.000 0301237000 3A Onion, bulb 2.000000 1.000 1.000 0301237001 3A Onion, bulb

- babyfood 2.000000 1.000 1.000 0301238000 3A Onion, bulb, dried 2.000000 9.000 1.000 0301238001 3A Onion, bulb, dried

- babyfood 2.000000 9.000 1.000 0301338000 3A Shallot, bulb 2.000000 1.000 1.000 0302103000 3B Chive, fresh leaves 2.000000 1.000 1.000 0302198000 3B L eek 2.000000 1.000 1.000 0302239000 3B Onion, green 2.000000 1.000 1.000 0302338500 3B Shallot, fresh leaves 2.000000 1.000 1.000 0401005000 4A Amaranth, leafy 10.000000 1.000 1.000 0401018000 4A Arugula 10.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 10.000000 1.000 1.000 0401133000 4A Cress, garden 10.000000 1.000 1.000 0401134000 4A Cress, upland 10.000000 1.000 1.000 0401138000 4A Dandelion, leaves 10.000000 1.000 1.000 0401150000 4A Endive 10.000000 1.000 1.000 0401204000 4A Lettuce, head 10.000000 1.000 1.000 0401205000 4A Lettuce, leaf 10.000000 1.000 1.000 0401248000 4A Parsley, leaves 10.000000 1.000 1.000 0401313000 4A Radicchio 10.000000 1.000 1.000Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 19 of 25 0401355000 4A Spinach 10.000000 1.000 1.000 0401355001 4A Spinach

- babyfood 10.000000 1.000 1.000 0501061000 5A Broccoli 1.200000 1.0 00 1.000 0501061001 5A Broccoli

- babyfood 1.200000 1.000 1.000 0501062000 5A Broccoli, Chinese 1.200000 1.000 1.000 0501064000 5A Brussels sprouts 1.200000 1.000 1.000 0501069000 5A Cabbage 1.200000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 0501083000 5A Cauliflow er 1.200000 1.000 1.000 0501196000 5A Kohlrabi 1.200000 1.000 1.000 0502063000 5B Broccoli raab 12.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 0502117000 5B Collards 12.000000 1.000 1.000 0502194000 5B Kale 12.000000 1.000 1.000 0502229000 5B Mustard greens 12.000000 1.000 1.000 0502318000 5B Rape greens 12.000000 1.000 1.000 0502389000 5B Turnip, greens 12.000000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.500000 1.000 1.000 0601043001 6A Bean, s nap, succulent

- babyfood 0.500000 1.000 1.000 0602031000 6B Bean, broad, succulent 0.080000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.080000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.080000 1.000 1.000 0801374000 8A Tomatillo 0.900000 1.000 1.000 0801375000 8A Tomato 0.900000 1.000 1.000 0801375001 8A Tomato

- babyfood 0.900000 1.000 1.00 0 0801376000 8A Tomato, paste 0.900000 1.000 1.000 0801376001 8A Tomato, paste

- babyfood 0.900000 1.000 1.000 0801377000 8A Tomato, puree 0.900000 1.000 1.000 0801377001 8A Tomat o, puree
- babyfood 0.900000 1.000 1.000 0801378000 8A Tomato, dried 0.900000 14.300 1.000 0801378001 8A Tomato, dried

- babyfood 0.900000 14.300 1.000 0801379000 8A Tomato, juice 0.900000 1.500 1.000 0801380000 8A Tomato, Tree 0.900000 1.000 1.000 0802148000 8BC Eggplant 0.900000 1.000 1.000 0802234000 8BC Okra 0.900000 1.000 1.000 0802270000 8B Pepper, bell 0.900000 1.000 1.000 0802270001 8B Pepper, bell

- babyfood 0.900000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.900000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 0.900000 1.000 1.000 0802272000 8BC Pepper, nonbell 0.900000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 0.900000 1.000 1 .000 0802273000 8BC Pepper, nonbell, dried 0.900000 1.000 1.000 0901075000 9A Cantaloupe 0.100000 1.000 1.000 0901187000 9A Honeydew melon 0.100000 1.000 1.000 0901399000 9A Wa termelon 0.100000 1.000 1.000 0901400000 9A Watermelon, juice 0.100000 1.000 1.000 0902021000 9B Balsam pear 0.100000 1.000 1.000 0902088000 9B Chayote, fruit 0.100000 1.000 1.000 0902102000 9B Chinese waxgourd 0.100000 1.000 1.000 0902135000 9B Cucumber 0.100000 1.000 1.000 0902308000 9B Pumpkin 0.100000 1.000 1.000 0902309000 9B Pumpkin, seed 0.100000 1.000 1.000 0902356000 9B Squash, summer 0.100000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.100000 1.000 1.000 0902357000 9B Squash, winter 0.100000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.100000 1.000 1.000 1304175000 13D Grape 1.500000 1.000 1.000 1304176000 13D Grape, juice 1.500000 1.000 1.000 1304176001 13D Grape, juice

- babyfood 1.500000 1.000 1.000 1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 1901028000 19A Basil, fresh leaves 90.000000 1.00 0 1.000 1901028001 19A Basil, fresh leaves

- babyfood 90.000000 1.000 1.000Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 20 of 25 1901029000 19A Basil, dried leaves 90.000000 1.000 1.000 1901029001 19A Basil, dried leaves

- babyfood 90.000000 1.000 1.000 1901102500 19A Chive, dried leaves 90.000000 1.000 1.000 1901118000 19A Cilantro, leaves 90.000000 1.000 1.000 1901118001 19A Cilantro, leaves

- babyfood 90.000000 1.000 1.000 1901144000 19A Dillweed 90.000000 1.000 1.000 1901184000 19A Herbs, other 90.000000 1.000 1.000 1901184001 19A Herbs, other

- babyfood 90.000000 1.000 1.000 1901202000 19A Lemongrass 90.000000 1. 000 1.000 1901220000 19A Marjoram 90.000000 1.000 1.000 1901220001 19A Marjoram

- babyfood 90.000000 1.000 1.000 1901249000 19A Parsley, dried leaves 90.000000 1.000 1.000 1901249001 1 9A Parsley, dried leaves

- babyfood 90.000000 1.000 1.000 1901334000 19A Savory 90.000000 1.000 1.000 8601000000 86A Water, direct, all sources 0.211000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.211000 1.000 1.000 9500177000 O Grape, leaves 1.500000 1.000 1.000 9500178000 O Grape, raisin 1.500000 1.000 1.000 9500188000 O Hop 10.000000 1.000 1.000Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 21 of 25 

### Chronic Food plus Water Results

US EPA Ver. 3.16, 03

- 08

- d
DEEM

- FCID Chronic analysis for CYAZOFAMID NHANES 2003

- 2008 2

- day Residue file name: C: \ Users \ cwalls \ Docume nts \ Cassi \ HED \ cyazofamid \ New Use 2015 \ dietary \ CHRONIC CYAZOFAMID FOOD+WATER 101015.R08 Adjustment factor #2 NOT used. Analysis Date 10

- 14

- 2015/11:02:37 Residue file dated: 10

- 14

- 2015/11:01:15 Reference d ose (RfD, Chronic) = .95 mg/kg bw/day COMMENT 1: Drinking water from PRZM

- GW

=============================================================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.010631 1.1% Hispanic 0.009996 1.1%
Non

- Hisp

- White 0.010871 1.1%
Non

- Hisp

- Black 0.009443 1.0%
Non

- Hisp

- Other 0.011929 1.3% Nursing Infants 0.006401 0.7%
Non

- Nursing Infants 0.020012 2.1% Female 13+ PREG 0.009 841 1.0% Children 1

- 6 0.016595 1.7% Children 7

- 12 0.009497 1.0% Male 13

- 19 0.007531 0.8% Female 13

- 19/NP 0.008080 0.9% Male 20+ 0.009738 1.0% Female 20+/NP 0.010962 1.2% Seniors 55+ 0.010087 1.1% All Infants 0.015810 1.7% Female 13

- 50 0.010422 1.1% Children 1

- 2 0.018609 2.0% Chi ldren 3

- 5 0.015997 1.7% Children 6

- 12 0.010164 1.1% Youth 13

- 19 0.007809 0.8% Adults 20

- 49 0.010452 1.1% Adults 50

- 99 0.010256 1.1% Female 13

- 49 0.010436 1.1%

---------------------------------------------------------------------- ---------Page 22 of 25 

### Chronic Food Only Residue Input File

Filename: C: \ Users \ cwalls \ Documents \ Cassi \ HED \ cyazofamid \ New Use 2015 \ dietary \ CHRONIC CYAZOFAMID FOOD only 101015.R08 Chemical: cyazofamid RfD(Chronic): .95 mg/kg bw/day NOEL(Chronic): 94.8 mg/kg bw/day RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day Date created/last modified: 10

- 07

- 2015/10:45:18 Program ver. 3.16, 03

- 08

- d Comment: Drinking water from PRZM

- GW

------------------------------------------------------------------------ ----------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 0 101078000 1AB Carrot 0.090000 1.000 1.000 0101078001 1AB Carrot

- babyfood 0.090000 1.000 1.000 0101079000 1AB Carrot, juice 0.090000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.020000 1.000 1.000 0103015001 1CD Arrowroot, flour

- babyfood 0.020000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 0103082000 1CD Cassava 0.020000 1.000 1.000 0103082001 1CD Cassava

- babyfood 0.020000 1.000 1.000 0103139000 1CD Dasheen, corm 0.020000 1.000 1.000 0103166000 1CD Ginger 0.020000 1.000 1.000 0103166001 1CD Ginger

- babyfood 0.020000 1.000 1.000 0103167000 1CD Ginger, dried 0.020000 1.000 1.000 0103296000 1C Potato, chips 0.020000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.020000 1.000 1.000 0103298000 1C Potato, flour 0.020000 1.000 1.000 0103298001 1C Potato, flour

- babyfood 0.020000 1.000 1.000 0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.020000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.020000 1.000 1.000 0103366000 1CD Sweet potato 0.020000 1.000 1.000 0103366001 1CD Sweet potato

- babyfood 0.020000 1.000 1.000 0103371000 1CD Tanier , corm 0.020000 1.000 1.000 0103387000 1CD Turmeric 0.020000 1.000 1.000 0103406000 1CD Yam, true 0.020000 1.000 1.000 0103407000 1CD Yam bean 0.020000 1.000 1.000 0301165000 3A Garlic, bulb 2.000000 1.000 1.000 0301165001 3A Garlic, bulb

- babyfood 2.000000 1.000 1.000 0301237000 3A Onion, bulb 2.000000 1.000 1.0 00 0301237001 3A Onion, bulb

- babyfood 2.000000 1.000 1.000 0301238000 3A Onion, bulb, dried 2.000000 9.000 1.000 0301238001 3A Onion, bulb, dried

- babyfood 2.000000 9.000 1.000 0301338000 3A Shal lot, bulb 2.000000 1.000 1.000 0302103000 3B Chive, fresh leaves 2.000000 1.000 1.000 0302198000 3B Leek 2.000000 1.000 1.000 0302239000 3B Onion, green 2.000000 1.000 1.000 0302338500 3B Shallot, fresh leaves 2.000000 1.000 1.000 0401005000 4A Amaranth, leafy 10.000000 1.000 1.000 0401018000 4A Arugula 10.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 10.000000 1.000 1.000 0401133000 4A Cress, garden 10.000000 1.000 1.000 0401134000 4A Cress, upland 10.000000 1.000 1.000 0401138000 4A D andelion, leaves 10.000000 1.000 1.000 0401150000 4A Endive 10.000000 1.000 1.000 0401204000 4A Lettuce, head 10.000000 1.000 1.000 0401205000 4A Lettuce, leaf 10.000000 1.000 1.000 0401248000 4A Parsley, leaves 10.000000 1.000 1.000 0401313000 4A Radicchio 10.000000 1.000 1.000Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 23 of 25 0401355000 4A Spinach 10.000000 1.000 1.000 0401355001 4A Spinach

- babyfood 10.000000 1.000 1.000 0501061000 5A Broccoli 1.200000 1.000 1.000 0501061001 5A Broccoli

- babyfood 1.200000 1.000 1.000 0501062000 5A Broccoli, Chinese 1.200000 1.000 1.000 0501064000 5A Brussels sprouts 1.200000 1.000 1.000 0501069000 5A Cabbage 1.200000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 0501083000 5A Cauliflower 1.200000 1.000 1.000 0501196000 5A Kohlrabi 1.200000 1.0 00 1.000 0502063000 5B Broccoli raab 12.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 0502117000 5B Collards 12.000000 1.000 1.000 0502194000 5B Kale 12.000000 1.000 1.000 0502229000 5B Mustard greens 12.000000 1.000 1.000 0502318000 5B Rape greens 12.000000 1.000 1.000 0502389000 5B Turnip, greens 12.000000 1.000 1.000 0601043000 6A Bean, snap, succulent 0.500000 1.000 1.000 0601043001 6A Bean, snap, succulent

- babyfood 0.500000 1.000 1.000 0602031000 6B Bean, bro ad, succulent 0.080000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 0.080000 1.000 1.000 0602037000 6B Bean, lima, succulent 0.080000 1.000 1.000 0801374000 8A Tomatillo 0.900000 1.000 1.000 0801375000 8A Tomato 0.900000 1.000 1.000 0801375001 8A Tomato

- babyfood 0.900000 1.000 1.000 0801376000 8A Tomato, paste 0.900000 1.000 1.000 0801376001 8A Tomato, paste

- babyfood 0.900000 1.000 1.000 0801377000 8A Tomato, puree 0.900000 1.000 1.000 0801377001 8A Tomato, puree

- babyfood 0.900000 1.000 1.000 0801378000 8A Tomato, dried 0.900000 14.300 1.000 0801378001 8A Tomato, dried

- babyfood 0.900000 14.300 1.000 0801379000 8A Tomato, juice 0.900000 1.500 1.000 0801380000 8A Tomato, Tree 0.900000 1.000 1.000 0802148000 8BC Eggplant 0.900000 1.000 1.000 0802234000 8BC Okra 0.900000 1.000 1.000 0802270000 8B Pepper, bell 0.900000 1.000 1.00 0 0802270001 8B Pepper, bell

- babyfood 0.900000 1.000 1.000 0802271000 8B Pepper, bell, dried 0.900000 1.000 1.000 0802271001 8B Pepper, bell, dried

- babyfood 0.900000 1.000 1.000 0802272000 8BC Peppe r, nonbell 0.900000 1.000 1.000 0802272001 8BC Pepper, nonbell

- babyfood 0.900000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 0.900000 1.000 1.000 0901075000 9A Cantaloupe 0.100000 1.000 1.000 0901187000 9A Honeydew melon 0.100000 1.000 1.000 0901399000 9A Watermelon 0.100000 1.000 1.000 0901400000 9A Watermelon, juice 0.100000 1.000 1.000 0902021000 9B Balsam pear 0.100000 1.000 1.000 0902088000 9B Chayote, fruit 0.100000 1.000 1.000 0902102000 9B Chinese waxgourd 0.100000 1.000 1.000 0902135000 9B C ucumber 0.100000 1.000 1.000 0902308000 9B Pumpkin 0.100000 1.000 1.000 0902309000 9B Pumpkin, seed 0.100000 1.000 1.000 0902356000 9B Squash, summer 0.100000 1.000 1.000 0902356001 9B Squash, summer

- babyfood 0.100000 1.000 1.000 0902357000 9B Squash, winter 0.100000 1.000 1.000 0902357001 9B Squash, winter

- babyfood 0.100000 1.000 1.000 1304175000 13D Grape 1.500000 1.000 1.000 1304176000 13D Grape, juice 1.500000 1.000 1.000 1304176001 13D Grape, juice

- babyfood 1.500000 1.000 1.000 1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 1901028000 19A Basil, fresh leaves 90.000000 1.000 1.000 1901028001 19A Basil, fresh leaves

- babyfood 90.000000 1.000 1.000Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 24 of 25 1901029000 19A Basil, dried leaves 90.000000 1.000 1.000 1901029001 19A Basil, dried leaves

- babyfood 90.000000 1.000 1.000 1901102500 19A Chive, dried leaves 90.000000 1.000 1.000 1901118000 19A Cilantro, leaves 90.000000 1.0 00 1.000 1901118001 19A Cilantro, leaves

- babyfood 90.000000 1.000 1.000 1901144000 19A Dillweed 90.000000 1.000 1.000 1901184000 19A Herbs, other 90.000000 1.000 1.000 1901184001 19 A Herbs, other

- babyfood 90.000000 1.000 1.000 1901202000 19A Lemongrass 90.000000 1.000 1.000 1901220000 19A Marjoram 90.000000 1.000 1.000 1901220001 19A Marjoram

- babyfood 90.000000 1.000 1.000 1901249000 19A Parsley, dried leaves 90.000000 1.000 1.000 1901249001 19A Parsley, dried leaves

- babyfood 90.000000 1.000 1.000 1901334000 19A Savory 90.000000 1.000 1.000 9500177000 O Grape, leaves 1.500000 1.000 1.000 9500178000 O Grape, raisin 1.500000 1.000 1.000 9500188000 O Hop 10.000000 1.000 1.000Page 25 of 25 

### Chronic Food Only Results

US EPA Ver. 3.16, 03

- 08

- d
DEEM

- FCID Chronic analysis for CYAZOFAMID NHANES 2003

- 2008 2

- day Residue file name: C: \ Users \ cwalls \ Documents \ Cassi \ HED \ cyazofamid \ New Use 2015 \ dietary \ CHRONIC CYAZOFAMID FOOD only 101015.R08 Adjustment factor #2 NOT used. Analysis Date 10

- 14

- 2015/11:01:57 Residue file dated: 10

- 14

- 2015/1 1:00:27 Reference dose (RfD, Chronic) = .95 mg/kg bw/day COMMENT 1: Drinking water from PRZM

- GW

=============================================================================== Total exposure by population subgroup

---------------------- ---------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.006213 0.7% His panic 0.005777 0.6%
Non

- Hisp

- White 0.006326 0.7%
Non

- Hisp

- Black 0.005797 0.6%
Non

- Hisp

- Other 0.006837 0.7% Nursing Infants 0.002404 0.3%
Non

- Nursing Infants 0.005318 0.6% Female 13+ PREG 0.005681 0. 6% Children 1

- 6 0.010936 1.2% Children 7

- 12 0.005813 0.6% Male 13

- 19 0.004494 0.5% Female 13

- 19/NP 0.004677 0.5% Male 20+ 0.005621 0.6% Female 20+/NP 0.006322 0.7% Seniors 55+ 0.005815 0.6% All Infants 0.004418 0.5% Female 13

- 50 0.006025 0.6% Children 1

- 2 0.012236 1.3% Children 3

- 5 0.010628 1.1% Children 6

- 12 0.006291 0.7% Youth 13

- 19 0.004587 0.5% Adults 20

- 49 0.006044 0.6% Adults 50

- 99 0.005898 0.6% Female 13

- 49 0.006044 0.6%

-------------------------------------------------------------------------------