UNITED STATES ENVIRONMENTAL PROTECTION AGENC Y WAS HINGTON , D C , 2046 0 

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OFFICE O F CHEMICAL SA FETY

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### MEMORANDUM SUBJEC T: B EAD C h emica l Profile for Regis tration Review on A sulam, Sodium Salt (106902 ) 

### FROM : Sunil Ratnayake B iologist , Bio logical Analysis Branch S epchr Haddad , E nvironmenta l Protection Speciali st Science Information and Ana ly s is Branch



### THR U: 

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# 0) Derek Berwald (,' ( l\.\ E conomist, Economic Ana ly sis Branch 

# n . J "- Bio logical and E conomic Analy sis Divi sion (750 3P) Arnet Jone s, C hief 

# A Bio logi ca l Ana ly sis Branc h D iann Sims, C hief Sc i ence Information and Ana l ysis Branch Timothy Kiely , C h ief 

# !\"'\ \,'v\! ' 

# 0 Economic Ana lysis Branch \j 

### j Bio logical and Economi c Ana ly sis Divi sion ( 7 503P) 

### T O: Rust y Wasem , Chemical Review Manager Pesticid e Re

- eva luation Division ( 7508P) 

### Peer Rev iew P anel D ate : August 31 , 2010 INTRODUC TIO N The purpo se of this document is to convey u sage informati on and a broad overview of the pe st management rol es o f pe sticide s that are beginning to und ergo registration revie w. The anticipated audience c onsists of the team of EPA s taff currently e val uating the regi stration s tatus of A sulam , and e ventually the general public . Thi s document bui lds up on the data a lready provided in the " Usage and Labe l Us e Data Package s" that are al so provided to Regi stration Re view team s b y B EAD.



### 1As ulam , s od i um s alt i s a h erbicide whic h be longs to th e ca rbama te c hemic al group a nd it is u s ed to contro l a v ariety of an nual g rass es and b roadleaf weed s i n s ugarcane, C h ristmas tree p lantations , o rnamental and s h ade tree s, o rname ntal woo d y s hrubs and v ines , tu rf (St . A ugustin egrass a nd Be rm udagras s) an d n on-cropland use s (bo undary f ence s , f encerows , h edgerow s , lumberyard s, s torage a reas, in du st rial plan t si te s, and wa rehou se lot s) ( EPA p roprietary da ta , 20 10). I t i s a s ystem ic herb icide and applied as a post-emergence herbicide. C urrently, five prod uct reg i s tration s are ac tive un der th i s a ctiv e ing redient ( EPA pr oprietary d ata, 20 10) . Asu lam , sod ium s a lt i s absorbed by l ea v e s, s hoot s and root s . T he m ode of ac tion o f as ulam so dium s alt i s inhi bition o f 7,8

- d ihy dropte roate (D HP) sy nth ase, an e nzyme invo lved in fo lic ac id s y nthesis ( PPDB, 20 I 0) . Ae rial and g round application s are re c ommended a s ap plication me thod s of thi s he rbicide (A s ulam Prod uct L abel , 20 02) . 

### C OMMON FORMULA TIO NS AN D APPLICATION METHODS A s ulam , s od i um s alt i s f orm ulated a s a liquid o nly. A su lam s odi um salt i s applied a s a ban d treatm ent, aerial, or a s gro und ap plicat ion u s ing tractor m ounted sprayer s. 

### U SAGE A g ric ul tural Us age Based o n private market pestic ide u s age da ta , th e a nnual total agr icultural usage averaged ap proximately 9 00 ,000 p ound s ac ti ve i ngredient (A . I.) fo r 350 , 000 acre s fro m 1998 -2008 (GfK Kynetec, 1998 -2 008) (F ig . 1 ) . T he p eak of use in pou nds A .I. and ac re s treate d occurre d in 1999 wi th a s teady d ecrease i n u s e and acres t reat e d through 2008 . U se dec rease d b y ove r 60 % be tween 2 007 and 2008. 

### F igure 1. 

### Acres Treated wit h Asulam S odium from 1998 to 2008 . Asu lam Acres Trea ted 6 00000



### 0 '- 1 998 199 9 2 000 2 001 Source : G fK Ky n etec, 1998 -2008 2002 2003 20 04 20 05 2006 2007 2 008 Year

2

### Figure 2. Usage of As ulam, Sodium Salt i n S ugarcane Su garcan e 1 .600.000

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o 1998 1999 2 000 2001 2 002 2003 2 004 2005 2006 2007 2008 Year S o urce : G IK K ynetec, 199 8

- 2008 From 1 998 -2 008 , t he larg e s t market in term s of total pou nd s o f a ctive i ngredie nt applied and ac re s treated w as f or s u g ar c an e, with a ve ry minimal a mount ( less tha n 1 %) u sed o n sug ar be ets . (G IK K ynetec, 1 998

- 200 8 ) ( Fig . 2 ). 

### Fi u re 

### 3. A r icu .tura) Us a e of Asulam, S odium Salt in Different S tates Pounds A."

So urce : G IK K ynetec, 1998 -2 008


### 3Th e states wit h the mos t agric ultural us age in term s of p ound s A I. applied are Fl orida a nd Lo uis iana w ith 83% and 1 7 %, respectively . (G fK K ynetec, 1 9 98-20 08) (Fig. 3) . T here was a lso so me u se in Texas and Mo ntana; howeve r, mo re th an 99 p ercent of th e u sage i s i n Flori da and L ouisiana . T hese sta tes are a lso th e largest i n term s of total ac res treated f rom 1998 -2008. No n -Agricultural Usage In te rms of non-agri cultural u sage, BEAD r eviewed available n on-agricultural so urces, b ut inf ormation w as limited o n use of as ulam in non- agr icultur al u se s ites to o nly tur f farms (125, 000 Ib s . A.I. in 2 004 , a nd 87 ,0 00 Ib s A.I. i n 20 06) . (K line & Com pany , In c. 20 04-2006) 

### BIOLOG ICAL ASPECTS RELEVANT TO ASULAM SODIUM SAL T As ulam , so dium sa lt bel on gs to D HP sy nthase i nhibitors . 

### It inhibits th e e nzyme di hyd ropt eroate syn thase. Dev elopment o f weed res istance to as ulam s od i um s a lt i s n ot re ported in th e International S urvey o f H erbicide Resis tant Weeds (Int ernational S urvey o f He rbicide Res istant Wee ds, 2010). 

### H ISTORY OF BEAD ASSESSMEN TS FOR ASULAM SODIUM SALT T here i s no reco rd of pri or B EAD a ssess ments fo r As ulam so dium sa lt . 

### DATA NEEDS RELEVANT TO BEAD'S FUTURE WORK ON AS ULAM SODIUM SALT Usage data i s needed, if ava ilable , f or n on-agr icultu ral u ses o f in dustrial areas, c omm ercial s torages /w are house p re m ises, and rig ht -of -ways. 

### REF ERENCES As ulam . Regi s tration E ligibility D eci si on F act s. E PA. 1 995. http ://,",,'W\\' .e pa.g ovl o ppsrrd l IR E D s/fact sheet slO 265fact. pd f As ulam Product Label 4F . 20 02. Helena C hemical Co mpany.**http :/** **ww cdm** **.n t!Lab** **el sM** **sd /LMD** **efault .a** **spx ?pd ~857** **6&t** G fK Kynetec, 1 998-2008 . Proprietary D ata. Pesticide P roperties Database (PPDB ) . 20 10 . As ulam, So dium . 2 010 . http ://sitem.herts.ac.uk/ a eruliupac /Report s/4 2. htm Kl ine & Co mpany. Pro fessiona l T urf and O rnamental Ma rket s For P esticides a nd Fertilizers USA T urf Farm s (200 4-2007) . Intern ational S urvey o f H erbicide Resis tant Weeds, 20 10. http ://w."...\\. . wecdrescarch.c oml summary/ChcmF amil ySum .a sp?lstActivc = 16 5&l stHRA C = 14&bt**nSub ~Go**  4