Exhibit 21



Pharmaceutical Product Development, Inc.,
and Subsidiaries

Subsidiaries



The subsidiaries of Pharmaceutical Product Development, Inc., as of February 3, 2003, are as follows:



|    |  | Name of Subsidiary                                            |  | Jurisdiction of Incorporation or Organized in
|--- |  | ------------------------------------------------------------- |  | ---------------------------------------------
|1.  |  | Applied Bioscience International Inc.                         |  | Delaware                                     
|2.  |  | PPD Development, LP                                           |  | Texas                                        
|3.  |  | PPD International Holdings, Inc.                              |  | Delaware                                     
|4.  |  | Pharmaco Investments Inc.                                     |  | Delaware                                     
|5.  |  | PPD France SNC                                                |  | France                                       
|6.  |  | PPD Scandinavia AB                                            |  | Sweden                                       
|7.  |  | PPD Canada, Ltd.                                              |  | Canada                                       
|8.  |  | PPD Do Brazil-Suporte a Pesquisa, LTDA                        |  | Brazil                                       
|9.  |  | PPD International Holdings GmbH                               |  | Germany                                      
|10. |  | PPD Germany GmbH                                              |  | Germany                                      
|11. |  | PPD Poland Sp. zo.o                                           |  | Poland                                       
|12. |  | PPD Czech Republic, S.r.o.                                    |  | Czech Republic                               
|13. |  | PPD Germany GmbH & Co. KG                                     |  | Germany                                      
|14. |  | PPD South Africa                                              |  | South Africa                                 
|15. |  | PPD Hungary R&D, Ltd.                                         |  | Hungary                                      
|16. |  | PPD UK Holdings Ltd.                                          |  | United Kingdom                               
|17. |  | PPD Global Ltd.                                               |  | United Kingdom                               
|18. |  | Leicester Clinical Research Centre, Ltd.                      |  | United Kingdom                               
|19. |  | Chelmsford Clinical Trials Unit Ltd.                          |  | United Kingdom                               
|20. |  | Gabbay Ltd.                                                   |  | United Kingdom                               
|21. |  | Data Analysis & Research (DAR), Ltd.                          |  | United Kingdom                               
|22. |  | PPD Aeronautics, LLC                                          |  | North Carolina                               
|23. |  | APBI Finance Corporation                                      |  | Delaware                                     
|24. |  | PPD Mexico S.A. de C.V.                                       |  | Mexico                                       
|25. |  | PPD Australia Pty Limited                                     |  | Australia                                    
|26. |  | PPD Italy SRL                                                 |  | Italy                                        
|27. |  | Pharmaceutical Product Development Spain SL                   |  | Spain                                        
|28. |  | PPD Development (Thailand) Co., Ltd.                          |  | Thailand                                     
|29. |  | Cambridge Applied Nutrition Toxicology and Bioscience Limited |  | United Kingdom                               
|30. |  | Clinical Technology Centre (International) Limited            |  | United Kingdom                               
|31. |  | Genupro, Inc.                                                 |  | North Carolina                               
|32. |  | Belmont Research, Inc.                                        |  | Massachusetts                                
|33  |  | PPD Discovery, Inc.                                           |  | North Carolina                               
|34. |  | Target Discovery, Inc.                                        |  | North Carolina                               
|35. |  | SARCO, Inc.                                                   |  | Delaware                                     
|36. |  | PPD Virtual, Inc.                                             |  | North Carolina                               
|37. |  | ATP, LLC.                                                     |  | North Carolina                               
|38. |  | Clinical Science Research International, Ltd.                 |  | United Kingdom                               
|39. |  | PPD Holdings, LLC                                             |  | Delaware                                     
|40. |  | PPD GP, LLC                                                   |  | Delaware                                     
|41. |  | PPD Japan, K.K.                                               |  | Japan                                        
|42. |  | Medical Research Laboratories International, LLC              |  | Kentucky                                     





---



|43. |  | Complete Software Solutions, Inc.                    |  | California    
|--- |  | ---------------------------------------------------- |  | --------------
|44. |  | Piedmont Research Center, Inc.                       |  | North Carolina
|45. |  | Medical Research Laboratories International, BVBA    |  | Belgium       
|46. |  | Propharma Pte Ltd                                    |  | Singapore     
|47. |  | Propharma Asia Ltd                                   |  | Hong Kong     
|48. |  | Propharma CRO Pty Ltd                                |  | Australia     
|49. |  | PPD Argentina, SA                                    |  | Argentina     
|50. |  | PPD International Holdings, Inc. Y Compania Limitada |  | Chile         



Subsidiaries 1, 22, 32,
33, 36, 42, 43, and 44 are wholly owned subsidiaries of Pharmaceutical Product Development, Inc.



Subsidiaries 16, 23, 39, and 40 are wholly owned subsidiaries of Subsidiary 1.



Subsidiary 2 is owned 99.9% by Subsidiary 39 and .1% by Subsidiary 40.



Subsidiaries 3, 4 and 37 are wholly owned subsidiaries of Subsidiary 2.



Subsidiary 5 is owned 99.9% by Subsidiary 3 and 0.1% by Subsidiary 1.



Subsidiaries 6, 7, 8, 9, 14, 24, 25, 26, 27, 28, and 41 are
wholly owned subsidiaries of Subsidiary 3.



Subsidiaries 10, 11
and 12 are wholly owned subsidiaries of Subsidiary 9.



Subsidiary
13 is owned 72% by Subsidiary 9 and 28% by Subsidiary 10.



Subsidiary 15 is owned 96.7% by Subsidiary 9 and 3.3% by Subsidiary 3.



Subsidiaries 17, 18, 19, 20, 21 and 46 are wholly owned subsidiaries of Subsidiary 16.



Subsidiaries 29, 30, and 38 are wholly owned subsidiaries of Subsidiary 17.



Subsidiaries 34 and 35 are wholly owned subsidiaries of Subsidiary 33.



Subsidiary 24 is owned 99% by Subsidiary 3 and 1% by Subsidiary 2.



Subsidiary 31 is a wholly owned subsidiary of Subsidiary 36.



Subsidiary 45 is owned 99.9% by Subsidiary 16 and 0.1% by Subsidiary 17.



Subsidiary 47 is owned 50% by Subsidiary 46 and 50% by
Subsidiary 1.



Subsidiary 48 is a wholly owned subsidiary of
Subsidiary 46.



Subsidiary 49 is owned 99.99% by Subsidiary 3 and
0.01% by Subsidiary 3.



Subsidiary 50 is owned 99% by Subsidiary
3 and 1% by Subsidiary 1.