UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM 

Date: I 0119/2015 

SUBJ ECT: Cyazofamid Acute and Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessments for the Section 3 Registration Action on Crop 

Subgroup l 9A and on Bulb Vegetables Crop Group 03-07. 

PC Code: 08565 l DP Barcodc: D430735 

Decision No.: 500741, 50074 7 

Petition No.: 5E8350, 5F8352 

Risk Assessment Type: Dietary 

TXR No.: NA 

Registration No.: 71512-2, 715 12-3 

Regulatory Action: Section 3 Registration 

Case No.: NA 

CAS No.: 120116-88-3 

MRJDNo.: NA 40 CFR: § 180.60 I 

FROM: 

THROUGH: 

TO: 

Cassi Wa lls, Ph.D., Senior Biologist ~ ;t__ WQQJ.,.) 

Risk Assessment Branch l 

Health Effects Division (HED, 7509P) 

Thurston Morton, Chemist // 

Mohsen Sahafeyan, Chemist . U Vti--

Dietary Exposure Science Advisory Council (pEYJ 

Barbara Madden/Laura Nollen, Risk Manager Team 05 

Risk Integration, Minor Use, and Emergency Response Branch (RlMUERB) 

and 

Lindsay Roe, Risk Manager 

Fungicide Branch 

Registration Division (7505P) 

Executive Summary 

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments 

were conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food 

consumption data from the U.S. Department of Agriculture's (USDA's) National Health and 

Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). The analyses 

were conducted in support of a human-health risk assessment for the proposed Section 3 uses of 

Page I of25 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735 

cyazofamid on Crop Subgroup l 9A and on Bulb Vegetables Crop Group 03-07. This 

memorandum was reviewed by two peer reviewers of the DES AC on I 0-28-20 I 5, per DES AC 

SOP20 12.I. 

Unrefined acute and chronic dietary exposure analyses were performed for the general U.S. 

population and various population subgroups. For the both dietary analyses, tolerance level 

residues and l 00% crop treated assumptions were used. DEEM default and empirical processing 

factors were used to modify the tolerance values. The assessments incorporated the ground 

water (PRZM-GW) drinking water estimates from application of cyazofamid to ornamentals. 

The estimated drinking water concentrations (EDWCs) used in the acute and chronic 

assessments were 224 ppb and 2 11 ppb, respectively. 

An acute dietary (food + drinking water) exposure assessment was performed for females 13-49 

years old only, since an acute endpoint of concern was not identified for the general population. 

Acute dietary risk estimates are not of concern for females 13-49 years old only which has a% 

acute Population-Adj usted Dose (aPAD) of 3. 1 %. 

Chronic dietary risk estimates are not of concern for the general U.S. population or any of the 

other population subgroups. The subgroup with the highest risk estimate is children 1-2 years 

old with a% chronic Population-Adjusted Dose (cPAD) of2.0%. The % cPAD for the general 

U.S. population is l. l %. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chroni c assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of depa1ture (POD) divided by the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: "Available Information on Assessing 

Exposure from Pesticides, A User's Guide," 2 l-JUN-2000, web link: 

http://wwvv.regulations.gov/# !documentDetail:D=EPA-HQ-OPP-2007-0780-000 I; or sec SOP 

99.6 (20-AUG-1999). 

The most recent dietary risk assessment for cyazofamid was conducted by Nancy Dodd ( 4/30/ 12, 

DP3972 14). 

II. Residue Information 

Cyazofamid is currently registered for food use under FIFRA sec. 3 on basil, beans (succulent), 

Brassica (subgroups A and B), carrot roots, hops, leafy greens (subgroup 4A), turnip greens, 

cucurbits (group 9), fruiting vegetables (group 8-10), and tuberous and corm (subgroup 1 C). 

Page 2 of25 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 3 of 25

Permanent tolerances for these commodities are established in 40 CFR §180.601at levels ranging 

from 0.02 ppm on potato to 90 ppm on dried basil. A tolerance with regional registration is 

established on grape at 1.5 ppm. No tolerances have been established on livestock commodities. 

Compliance with all tolerances specified in 40 CFR §180.601 is to be determined by measuring 

only the sum of cyazofamid and its metabolite, 4-chloro-5-p-tolylimidazole-2-carbonitrile

(CCIM), calculated as the stoichiometric equivalent of cyazofamid. 

The nature of cyazofamid residues in plants is adequately understood. The HED Metabolism 

Assessment Review Committee (MARC) determined in a meeting on 2/18/04 that the residues of 

concern for risk assessment are parent and CCIM in plants, parent only in rotational crops, and 

parent, CCIM, CCIM-AM, and CTCA in water. For livestock commodities, the proposed and 

established uses fall under 40 CFR §180.6(a)(3), i.e., there is no reasonable expectation of finite 

residues in livestock commodities.

The conservative acute and chronic analyses assumed that cyazofamid residues are present in/on 

all proposed and registered food commodities at tolerance levels and that 100% of all 

commodities are treated. Adequate processing data are available for currently registered 

commodities. The results of these studies indicate that combined residues of cyazofamid and 

CCIM in processed commodities are not expected to exceed the tolerances on the raw 

agricultural commodities. Therefore, processing factors were set to 1x, except that default 

processing factors were used for dried tomatoes and tomato juice since those commodities are 

not required to be analyzed in processing studies. The food residue data used in the acute and 

chronic analyses are summarized in Table 1 below.

Table 1. Residue Data Used in the Acute and Chronic Dietary Analyses for Cyazofamid

Commodity Existing 

Tolerance 

(ppm)

Recommended

Tolerance 

(ppm)

Processing 

Factors

Basil, fresh leaves 90

NA2

NA2

Basil, dried leaves 90

Bean, succulent 0.5

Bean, succulent, shelled 0.08

Brassica, head and stem, subgroup 5A 1.2

Brassica, leafy greens, subgroup 5B 12

Carrot, roots 0.09

Hop dried cones 10.0

Leafy greens, subgroup 4A 10

Turnip greens 12.0

Vegetable, cucurbit, group 9 0.10

Vegetable, tuberous and corm, subgroup 

1C

0.02

Vegetable, fruiting, group 8-10 0.9 Dried tomato 14.3

Tomato juice 1.5

Grapes 1.5

Bulb vegetables, group 3-07 NA22.0 NA2

Herb subgroup 19A 2.0

2 NA = not applicable.
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

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The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 2008, 2009, 

and 2010. In general, pesticide residues would not be expected to be found in fish unless the 

pesticide bioaccumulates or has an aquatic use. To determine whether or not residues are present 

in fish, HED now routinely checks PDP monitoring data regardless of the pesticide’s uses and 

physicochemical properties. However, PDP did not analyze catfish samples for cyazofamid. As 

a result, residues in fish were not included in the assessment. 

III. Percent Crop Treated Information

100 percent crop treated estimates were used in the acute and chronic dietary risk assessments.

IV. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: “Estimated 

Drinking Water Concentrations of Cyazofamid and its Degradates of Concern CCIM, CCIM-AM 

and CTCA, for Use in Human Health Risk Assessment: Petitions for the Use on Herb (Subgroup 

19A), Greenhouse Tomato, Greenhouse Pepper, and Bulb Vegetables (Group 03-07)” (D426776, 

J. Meléndez, 10/06/15) and incorporated directly into this dietary assessment. Water residues were 

incorporated in the DEEM-FCID into the food categories “water, direct, all sources” and “water, 

indirect, all sources.” 

As shown in Table 2 below, the acute value of 224 ppb and the non-cancer chronic value of 211 

ppb were the EDWCs which were directly entered into the exposure model to assess the 

contributions from drinking water. These EDWCs were modeled using PRZM-GW (Pesticide 

Root Zone Model for Groundwater) for residues in groundwater from use on ornamentals, which 

had the highest seasonal rates among the proposed and registered uses. Acute and chronic 

EDWCs in surface water as modeled by PRZM-EXAMS (Pesticide Root Zone Model/Exposure 

Analysis Modeling System) were lower. It should be noted that, given that groundwater 

exposure occurs usually after a long period of time, the terminal degradate of cyazofamid

(CTCA) was modeled in lieu of the parent cyazofamid plus other degradates. It was assumed 

100% CTCA formation from the parent compound. 

Table 2. Maximum Estimated Drinking Water Concentrations for Cyazofamid, CCIM, CCIM-AM and 

CTCA. Maximum EDWCs Are Based on the Use on Turf and Ornamentals

Drinking Water 

Source (Model Used) 

Use (rate modeled per 

year)

Estimated Drinking Water Concentration (EDWC) 

(ppb) (Species)

Groundwater

(PRZM-GW)

Ornamentals (3.12 lb 

a.i./A/yr)

Acute (CTCA) 2241

Chronic (CTCA) 2111

Surface water

(PRZM/EXAMS)

Turf & Ornamentals

(3.0 & 3.12 lb a.i./A/yr, 

respectively)

Acute (cyazofamid, CCIM, CCIM-AM) 38.22

Chronic (CTCA) 133.52

Cancer/Chronic (CTCA) 77.32

1. For groundwater, acute and chronic exposure is based on modeling the degradate CTCA.

2. For surface water, acute exposure is based on modeling of the parent cyazofamid plus the degradates CCIM 

and CCIM-AM. Chronic exposure is based on modeling of the degradate CTCA.

The drinking water models and their descriptions are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 5 of 25

V. DEEM-FCID Program and Consumption Information

Cyazofamid acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99

years old.

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment.

VI. Toxicological Information

Following repeated administration in more than one species, cyazofamid seems to have mild or 

low toxicity. The kidney appeared to be affected the most. Skin lesions were observed in male 

mice only, likely due to systemic allergy. In dogs, there were no major toxicity findings. In the 

acute neurotoxicity study, there were no indications of treatment-related adverse neurotoxicity.

The pre- and post-natal toxicology database for cyazofamid includes rat and rabbit 

developmental toxicity studies and a two-generation reproduction toxicity study in rats. There 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 6 of 25

was some evidence of increased susceptibility following in utero exposure to rats in the prenatal 

developmental toxicity study; the increased incidence of bent ribs in the high-dose fetuses was 

considered adverse and was used for setting the developmental NOAEL/LOAEL (no observed 

adverse effect level/lowest observed adverse effect level). HED considers this approach 

conservative and highly protective because bent ribs are a reversible developmental anomaly 

rather than a malformation.

Cyazofamid is classified as “not likely to be carcinogenic to humans” based on the lack of 

evidence of carcinogenicity in both the rat and the mouse studies. Additionally, cyazofamid does 

not appear to be mutagenic, based on several negative in vivo and in vitro studies.

The HED cyazofamid risk assessment team has recommended that the FQPA Safety Factor be 

reduced to 1X (DP# D356837, N. Tsaur, 20-MAY-2009; DP# D370671, N. Tsaur, 7-APR-2010). 

In brief, the toxicology database is adequate for the purpose of characterization of potential preand postnatal risks to infants and children. The concern is low for the quantitative susceptibility 

seen in the rat developmental toxicity study and there are no residual uncertainties. There were 

no indications of pre-and/or postnatal toxicity and no residual uncertainties from the rabbit 

developmental study or the rat two-generation reproduction study. Although a subchronic 

neurotoxicity study is not available, the acute neurotoxicity study showed no neurotoxic effects. 

Neurotoxicity and immunotoxicity were not demonstrated in the available studies. The dietary 

(food and water) and residential exposure assessments are conservative and are not likely to 

underestimate the potential exposures.

Table 3. Summary of Toxicological Doses and Endpoints for Cyazofamid for Use in Dietary 

Exposure Risk Assessments.

Exposure/

Scenario

Point of 

Departure

(PoD)

Uncertainty/F

QPA Safety 

Factors

RfD, PAD, 

Level of 

Concern 

Study and Toxicological Effects

Acute Dietary 

(General 

Population, 

including 

Infants and 

Children)

No adverse effects were observed which could be attributed to a single-dose exposure for the 

general population.

Acute Dietary

(Females 13-

49 years of 

age)

NOAEL = 

100 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 

1X

Acute RfD = 1.0 

mg/kg/day

aPAD = 1.0 

mg/kg/day

Rat Prenatal Developmental Toxicity 

(MRID 45408933)

LOAEL = 1,000 mg/kg/day based on 

developmental toxicity findings of 

increased incidence of bent ribs.

Chronic 

Dietary (All 

Populations)

NOAEL= 

94.8 

mg/kg/day

UFA = 10X

UFH = 10X

FQPA SF = 

1X

Chronic RfD = 

0.95 mg/kg/day

cPAD = 0.95 

mg/kg/day

18-Month Mouse Oral Carcinogenicity 

(MRID 45408932)

LOAEL = 985 mg/kg/day based on 

increased skin lesions.

Cancer (oral, 

dermal, 

inhalation)

Classification: “Not likely to be Carcinogenic to Humans” based on the absence of 

significant tumor increases in two adequate rodent carcinogenicity studies.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 7 of 25

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in 

sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = 

population adjusted dose (a = acute, c = chronic). RfD = reference dose. N/A = not applicable.

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in Table 4 are for the general 

U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50+ years old. 

Results of Acute Dietary (Food and Drinking Water) Exposure Analysis

An acute dietary (food + drinking water) exposure assessment was performed for females 13-49 

years old only, since an acute endpoint of concern was not identified for the general population. 

The acute dietary (food and drinking water) exposure assessment is conservative, i.e., based on 

the assumption that residues in all crops are at the tolerance levels and that 100% of the crops are 

treated (100% CT). The acute dietary risk assessment shows that the acute dietary risk estimates 

are below HED’s level of concern (i.e., <100% of the acute population adjusted dose (cPAD)). 

The acute dietary risk estimate for females 13-49 years old at the 95th percentile of exposure was 

3.1% of the aPAD. The results of the acute dietary exposure analysis are reported in Table 4 

below. 

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The chronic dietary (food and drinking water) exposure assessment is conservative, i.e., based on 

the assumption that residues in all crops are at the tolerance levels and that 100% of the crops are 

treated (100% CT). The chronic dietary risk assessment shows that the chronic dietary risk 

estimates are below HED’s level of concern (i.e., <100% of the chronic population adjusted dose 

(cPAD)). For the general U.S. population, the exposure for food and drinking water utilized 

1.1% of the cPAD. The chronic dietary risk estimate for the highest reported exposed population 

subgroup, children (1-2 years old), was 2.0% of the cPAD. The results of the chronic dietary 

exposure analysis are reported in Table 4 below. 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 8 of 25

Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Cyazofamid.

Population Subgroup

Acute Dietary

(95th Percentile) Chronic Dietary Cancer

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

Dietary 

Exposure

(mg/kg/day)

Risk

General U.S. Population

NA1 NA

0.010631 1.1

N/A N/A

All Infants (< 1 year old) 0.015810 1.7

Children 1-2 years old 0.018609 2.0

Children 3-5 years old 0.015997 1.7

Children 6-12 years old 0.010164 1.1

Youth 13-19 years old 0.007809 <1%

Adults 20-49 years old 0.010452 1.1

Adults 50+ years old 0.010256 1.1

Females 13-49 years old 0.031118 3.1 0.010436 1.1

1 NA = Not Applicable

VIII. Characterization of Inputs/Outputs

The acute and chronic dietary exposure and risk estimates are conservative since they assume 

that 100% of the crops are treated with cyazofamid and that residues are present at tolerance 

levels. In addition, EDWCs were based on screening level estimates generated by the PRZMGW model. Dietary exposure estimates could be refined through the use of anticipated residues 

and percent crop treated data, as well as refined estimated drinking water concentrations. 

However, since estimated exposures and risks using conservative assumptions are well below the 

Agency’s level of concern, such refinement is not warranted.

IX. Conclusions

These conservative dietary exposure analyses using DEEM-FCIDTM indicate that acute and 

chronic dietary exposures to cyazofamid from food and drinking water are well below the 

Agency’s level of concern. Both assessments were conservative, i.e., the assessments assumed 

that residues in all crops were at tolerance levels and that 100% of the crops were treated. An 

acute endpoint was not identified for the general U.S. population. The estimated acute exposure 

of females 13-49 years old, the only population subgroup of concern for acute exposure, 

represents 3.1% of the aPAD at the 95th percentile of exposure. Estimated chronic dietary

exposures are 1.1% of the cPAD for the general U.S. population and 2.0% of the cPAD for the 

highest reported exposed population subgroup, children (1-2 years old).
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 9 of 25

X. List of Attachments

• Acute Food plus Water Residue Input File.

• Acute Food plus Water Results File.

• Acute Food Only Residue Input File.

• Acute Food Only Results File

• Chronic Food plus Water Residue Input File.

• Chronic Food plus Water Results File.

• Chronic Food Only Residue Input File.

• Chronic Food Only Results File.
Page 10 of 25

Acute Food plus Water Residue Input File

Filename: C:\Users\cwalls\Documents\Cassi\HED\cyazofamid\New Use 2015\dietary\ACUTE 

CYAZOFAMID FOOD+WATER 101015.R08

Chemical: cyazofamid

RfD(Chronic): .95 mg/kg bw/day NOEL(Chronic): 94.8 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day

Date created/last modified: 10-07-2015/10:42:04 Program ver. 3.16, 03-08-d

Comment: Drinking water from PRZM-GW

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101078000 1AB Carrot 0.090000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.090000 1.000 1.000 

0101079000 1AB Carrot, juice 0.090000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.020000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.020000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 

0103082000 1CD Cassava 0.020000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.020000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.020000 1.000 1.000 

0103166000 1CD Ginger 0.020000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.020000 1.000 1.000 

0103167000 1CD Ginger, dried 0.020000 1.000 1.000 

0103296000 1C Potato, chips 0.020000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.020000 1.000 1.000 

0103298000 1C Potato, flour 0.020000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 0.020000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 

0103366000 1CD Sweet potato 0.020000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.020000 1.000 1.000 

0103371000 1CD Tanier, corm 0.020000 1.000 1.000 

0103387000 1CD Turmeric 0.020000 1.000 1.000 

0103406000 1CD Yam, true 0.020000 1.000 1.000 

0103407000 1CD Yam bean 0.020000 1.000 1.000 

0301165000 3A Garlic, bulb 2.000000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 2.000000 1.000 1.000 

0301237000 3A Onion, bulb 2.000000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 2.000000 1.000 1.000 

0301238000 3A Onion, bulb, dried 2.000000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 2.000000 9.000 1.000 

0301338000 3A Shallot, bulb 2.000000 1.000 1.000 

0302103000 3B Chive, fresh leaves 2.000000 1.000 1.000 

0302198000 3B Leek 2.000000 1.000 1.000 

0302239000 3B Onion, green 2.000000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 2.000000 1.000 1.000 

0401005000 4A Amaranth, leafy 10.000000 1.000 1.000 

0401018000 4A Arugula 10.000000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 10.000000 1.000 1.000 

0401133000 4A Cress, garden 10.000000 1.000 1.000 

0401134000 4A Cress, upland 10.000000 1.000 1.000 

0401138000 4A Dandelion, leaves 10.000000 1.000 1.000 

0401150000 4A Endive 10.000000 1.000 1.000 

0401204000 4A Lettuce, head 10.000000 1.000 1.000 

0401205000 4A Lettuce, leaf 10.000000 1.000 1.000 

0401248000 4A Parsley, leaves 10.000000 1.000 1.000 

0401313000 4A Radicchio 10.000000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 11 of 25

0401355000 4A Spinach 10.000000 1.000 1.000 

0401355001 4A Spinach-babyfood 10.000000 1.000 1.000 

0501061000 5A Broccoli 1.200000 1.000 1.000 

0501061001 5A Broccoli-babyfood 1.200000 1.000 1.000 

0501062000 5A Broccoli, Chinese 1.200000 1.000 1.000 

0501064000 5A Brussels sprouts 1.200000 1.000 1.000 

0501069000 5A Cabbage 1.200000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 

0501083000 5A Cauliflower 1.200000 1.000 1.000 

0501196000 5A Kohlrabi 1.200000 1.000 1.000 

0502063000 5B Broccoli raab 12.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 

0502117000 5B Collards 12.000000 1.000 1.000 

0502194000 5B Kale 12.000000 1.000 1.000 

0502229000 5B Mustard greens 12.000000 1.000 1.000 

0502318000 5B Rape greens 12.000000 1.000 1.000 

0502389000 5B Turnip, greens 12.000000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.500000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.500000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.080000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.080000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.080000 1.000 1.000 

0801374000 8A Tomatillo 0.900000 1.000 1.000 

0801375000 8A Tomato 0.900000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.900000 1.000 1.000 

0801376000 8A Tomato, paste 0.900000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 0.900000 1.000 1.000 

0801377000 8A Tomato, puree 0.900000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 0.900000 1.000 1.000 

0801378000 8A Tomato, dried 0.900000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.900000 14.300 1.000 

0801379000 8A Tomato, juice 0.900000 1.500 1.000 

0801380000 8A Tomato, Tree 0.900000 1.000 1.000 

0802148000 8BC Eggplant 0.900000 1.000 1.000 

0802234000 8BC Okra 0.900000 1.000 1.000 

0802270000 8B Pepper, bell 0.900000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.900000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.900000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.900000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.900000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.900000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.900000 1.000 1.000 

0901075000 9A Cantaloupe 0.100000 1.000 1.000 

0901187000 9A Honeydew melon 0.100000 1.000 1.000 

0901399000 9A Watermelon 0.100000 1.000 1.000 

0901400000 9A Watermelon, juice 0.100000 1.000 1.000 

0902021000 9B Balsam pear 0.100000 1.000 1.000 

0902088000 9B Chayote, fruit 0.100000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.100000 1.000 1.000 

0902135000 9B Cucumber 0.100000 1.000 1.000 

0902308000 9B Pumpkin 0.100000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.100000 1.000 1.000 

0902356000 9B Squash, summer 0.100000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.100000 1.000 1.000 

0902357000 9B Squash, winter 0.100000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.100000 1.000 1.000 

1304175000 13D Grape 1.500000 1.000 1.000 

1304176000 13D Grape, juice 1.500000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 1.500000 1.000 1.000 

1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 

1901028000 19A Basil, fresh leaves 90.000000 1.000 1.000 

1901028001 19A Basil, fresh leaves-babyfood 90.000000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 12 of 25

1901029000 19A Basil, dried leaves 90.000000 1.000 1.000 

1901029001 19A Basil, dried leaves-babyfood 90.000000 1.000 1.000 

1901102500 19A Chive, dried leaves 90.000000 1.000 1.000 

1901118000 19A Cilantro, leaves 90.000000 1.000 1.000 

1901118001 19A Cilantro, leaves-babyfood 90.000000 1.000 1.000 

1901144000 19A Dillweed 90.000000 1.000 1.000 

1901184000 19A Herbs, other 90.000000 1.000 1.000 

1901184001 19A Herbs, other-babyfood 90.000000 1.000 1.000 

1901202000 19A Lemongrass 90.000000 1.000 1.000 

1901220000 19A Marjoram 90.000000 1.000 1.000 

1901220001 19A Marjoram-babyfood 90.000000 1.000 1.000 

1901249000 19A Parsley, dried leaves 90.000000 1.000 1.000 

1901249001 19A Parsley, dried leaves-babyfood 90.000000 1.000 1.000 

1901334000 19A Savory 90.000000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.224000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.224000 1.000 1.000 

9500177000 O Grape, leaves 1.500000 1.000 1.000 

9500178000 O Grape, raisin 1.500000 1.000 1.000 

9500188000 O Hop 10.000000 1.000 1.000 
Page 13 of 25

Acute Food plus Water Results File

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for CYAZOFAMID NHANES 2003-2008 2-Day

Residue file: ACUTE CYAZOFAMID FOOD+WATER 101015.R08

Adjustment factor #2 NOT used.

Analysis Date: 10-14-2015/11:17:23 Residue file dated: 10-14-2015/10:59:39

NOEL (Acute) = 100.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

Run Comment: "Drinking water from PRZM-GW"

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Female 13-49:

 0.031118 3.11 3213 0.048160 4.82 2076 0.077492 7.75 1290 
Page 14 of 25

Acute Food Only Residue Input File

Filename: C:\Users\cwalls\Documents\Cassi\HED\cyazofamid\New Use 2015\dietary\ACUTE 

CYAZOFAMID FOOD only 101015.R08

Chemical: cyazofamid

RfD(Chronic): .95 mg/kg bw/day NOEL(Chronic): 94.8 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day

Date created/last modified: 10-07-2015/10:44:20 Program ver. 3.16, 03-08-d

Comment: Drinking water from PRZM-GW

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101078000 1AB Carrot 0.090000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.090000 1.000 1.000 

0101079000 1AB Carrot, juice 0.090000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.020000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.020000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 

0103082000 1CD Cassava 0.020000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.020000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.020000 1.000 1.000 

0103166000 1CD Ginger 0.020000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.020000 1.000 1.000 

0103167000 1CD Ginger, dried 0.020000 1.000 1.000 

0103296000 1C Potato, chips 0.020000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.020000 1.000 1.000 

0103298000 1C Potato, flour 0.020000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 0.020000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 

0103366000 1CD Sweet potato 0.020000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.020000 1.000 1.000 

0103371000 1CD Tanier, corm 0.020000 1.000 1.000 

0103387000 1CD Turmeric 0.020000 1.000 1.000 

0103406000 1CD Yam, true 0.020000 1.000 1.000 

0103407000 1CD Yam bean 0.020000 1.000 1.000 

0301165000 3A Garlic, bulb 2.000000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 2.000000 1.000 1.000 

0301237000 3A Onion, bulb 2.000000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 2.000000 1.000 1.000 

0301238000 3A Onion, bulb, dried 2.000000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 2.000000 9.000 1.000 

0301338000 3A Shallot, bulb 2.000000 1.000 1.000 

0302103000 3B Chive, fresh leaves 2.000000 1.000 1.000 

0302198000 3B Leek 2.000000 1.000 1.000 

0302239000 3B Onion, green 2.000000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 2.000000 1.000 1.000 

0401005000 4A Amaranth, leafy 10.000000 1.000 1.000 

0401018000 4A Arugula 10.000000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 10.000000 1.000 1.000 

0401133000 4A Cress, garden 10.000000 1.000 1.000 

0401134000 4A Cress, upland 10.000000 1.000 1.000 

0401138000 4A Dandelion, leaves 10.000000 1.000 1.000 

0401150000 4A Endive 10.000000 1.000 1.000 

0401204000 4A Lettuce, head 10.000000 1.000 1.000 

0401205000 4A Lettuce, leaf 10.000000 1.000 1.000 

0401248000 4A Parsley, leaves 10.000000 1.000 1.000 

0401313000 4A Radicchio 10.000000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 15 of 25

0401355000 4A Spinach 10.000000 1.000 1.000 

0401355001 4A Spinach-babyfood 10.000000 1.000 1.000 

0501061000 5A Broccoli 1.200000 1.000 1.000 

0501061001 5A Broccoli-babyfood 1.200000 1.000 1.000 

0501062000 5A Broccoli, Chinese 1.200000 1.000 1.000 

0501064000 5A Brussels sprouts 1.200000 1.000 1.000 

0501069000 5A Cabbage 1.200000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 

0501083000 5A Cauliflower 1.200000 1.000 1.000 

0501196000 5A Kohlrabi 1.200000 1.000 1.000 

0502063000 5B Broccoli raab 12.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 

0502117000 5B Collards 12.000000 1.000 1.000 

0502194000 5B Kale 12.000000 1.000 1.000 

0502229000 5B Mustard greens 12.000000 1.000 1.000 

0502318000 5B Rape greens 12.000000 1.000 1.000 

0502389000 5B Turnip, greens 12.000000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.500000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.500000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.080000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.080000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.080000 1.000 1.000 

0801374000 8A Tomatillo 0.900000 1.000 1.000 

0801375000 8A Tomato 0.900000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.900000 1.000 1.000 

0801376000 8A Tomato, paste 0.900000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 0.900000 1.000 1.000 

0801377000 8A Tomato, puree 0.900000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 0.900000 1.000 1.000 

0801378000 8A Tomato, dried 0.900000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.900000 14.300 1.000 

0801379000 8A Tomato, juice 0.900000 1.500 1.000 

0801380000 8A Tomato, Tree 0.900000 1.000 1.000 

0802148000 8BC Eggplant 0.900000 1.000 1.000 

0802234000 8BC Okra 0.900000 1.000 1.000 

0802270000 8B Pepper, bell 0.900000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.900000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.900000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.900000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.900000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.900000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.900000 1.000 1.000 

0901075000 9A Cantaloupe 0.100000 1.000 1.000 

0901187000 9A Honeydew melon 0.100000 1.000 1.000 

0901399000 9A Watermelon 0.100000 1.000 1.000 

0901400000 9A Watermelon, juice 0.100000 1.000 1.000 

0902021000 9B Balsam pear 0.100000 1.000 1.000 

0902088000 9B Chayote, fruit 0.100000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.100000 1.000 1.000 

0902135000 9B Cucumber 0.100000 1.000 1.000 

0902308000 9B Pumpkin 0.100000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.100000 1.000 1.000 

0902356000 9B Squash, summer 0.100000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.100000 1.000 1.000 

0902357000 9B Squash, winter 0.100000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.100000 1.000 1.000 

1304175000 13D Grape 1.500000 1.000 1.000 

1304176000 13D Grape, juice 1.500000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 1.500000 1.000 1.000 

1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 

1901028000 19A Basil, fresh leaves 90.000000 1.000 1.000 

1901028001 19A Basil, fresh leaves-babyfood 90.000000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 16 of 25

1901029000 19A Basil, dried leaves 90.000000 1.000 1.000 

1901029001 19A Basil, dried leaves-babyfood 90.000000 1.000 1.000 

1901102500 19A Chive, dried leaves 90.000000 1.000 1.000 

1901118000 19A Cilantro, leaves 90.000000 1.000 1.000 

1901118001 19A Cilantro, leaves-babyfood 90.000000 1.000 1.000 

1901144000 19A Dillweed 90.000000 1.000 1.000 

1901184000 19A Herbs, other 90.000000 1.000 1.000 

1901184001 19A Herbs, other-babyfood 90.000000 1.000 1.000 

1901202000 19A Lemongrass 90.000000 1.000 1.000 

1901220000 19A Marjoram 90.000000 1.000 1.000 

1901220001 19A Marjoram-babyfood 90.000000 1.000 1.000 

1901249000 19A Parsley, dried leaves 90.000000 1.000 1.000 

1901249001 19A Parsley, dried leaves-babyfood 90.000000 1.000 1.000 

1901334000 19A Savory 90.000000 1.000 1.000 

9500177000 O Grape, leaves 1.500000 1.000 1.000 

9500178000 O Grape, raisin 1.500000 1.000 1.000 

9500188000 O Hop 10.000000 1.000 1.000 
Page 17 of 25

Acute Food Only Results 

US EPA Ver. 3.18, 03-08-d

DEEM-FCID ACUTE Analysis for CYAZOFAMID NHANES 2003-2008 2-Day

Residue file: ACUTE CYAZOFAMID FOOD only 101015.R08

Adjustment factor #2 NOT used.

Analysis Date: 10-14-2015/11:03:59 Residue file dated: 10-14-2015/10:58:41

NOEL (Acute) = 100.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

Run Comment: "Drinking water from PRZM-GW"

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Female 13-49:

 0.023040 2.30 4340 0.041042 4.10 2436 0.068463 6.85 1460 
Page 18 of 25

Chronic Food plus Water Residue Input File

Filename: C:\Users\cwalls\Documents\Cassi\HED\cyazofamid\New Use 2015\dietary\CHRONIC 

CYAZOFAMID FOOD+WATER 101015.R08

Chemical: cyazofamid

RfD(Chronic): .95 mg/kg bw/day NOEL(Chronic): 94.8 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day

Date created/last modified: 10-07-2015/10:39:01 Program ver. 3.16, 03-08-d

Comment: Drinking water from PRZM-GW

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101078000 1AB Carrot 0.090000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.090000 1.000 1.000 

0101079000 1AB Carrot, juice 0.090000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.020000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.020000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 

0103082000 1CD Cassava 0.020000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.020000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.020000 1.000 1.000 

0103166000 1CD Ginger 0.020000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.020000 1.000 1.000 

0103167000 1CD Ginger, dried 0.020000 1.000 1.000 

0103296000 1C Potato, chips 0.020000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.020000 1.000 1.000 

0103298000 1C Potato, flour 0.020000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 0.020000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 

0103366000 1CD Sweet potato 0.020000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.020000 1.000 1.000 

0103371000 1CD Tanier, corm 0.020000 1.000 1.000 

0103387000 1CD Turmeric 0.020000 1.000 1.000 

0103406000 1CD Yam, true 0.020000 1.000 1.000 

0103407000 1CD Yam bean 0.020000 1.000 1.000 

0301165000 3A Garlic, bulb 2.000000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 2.000000 1.000 1.000 

0301237000 3A Onion, bulb 2.000000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 2.000000 1.000 1.000 

0301238000 3A Onion, bulb, dried 2.000000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 2.000000 9.000 1.000 

0301338000 3A Shallot, bulb 2.000000 1.000 1.000 

0302103000 3B Chive, fresh leaves 2.000000 1.000 1.000 

0302198000 3B Leek 2.000000 1.000 1.000 

0302239000 3B Onion, green 2.000000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 2.000000 1.000 1.000 

0401005000 4A Amaranth, leafy 10.000000 1.000 1.000 

0401018000 4A Arugula 10.000000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 10.000000 1.000 1.000 

0401133000 4A Cress, garden 10.000000 1.000 1.000 

0401134000 4A Cress, upland 10.000000 1.000 1.000 

0401138000 4A Dandelion, leaves 10.000000 1.000 1.000 

0401150000 4A Endive 10.000000 1.000 1.000 

0401204000 4A Lettuce, head 10.000000 1.000 1.000 

0401205000 4A Lettuce, leaf 10.000000 1.000 1.000 

0401248000 4A Parsley, leaves 10.000000 1.000 1.000 

0401313000 4A Radicchio 10.000000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 19 of 25

0401355000 4A Spinach 10.000000 1.000 1.000 

0401355001 4A Spinach-babyfood 10.000000 1.000 1.000 

0501061000 5A Broccoli 1.200000 1.000 1.000 

0501061001 5A Broccoli-babyfood 1.200000 1.000 1.000 

0501062000 5A Broccoli, Chinese 1.200000 1.000 1.000 

0501064000 5A Brussels sprouts 1.200000 1.000 1.000 

0501069000 5A Cabbage 1.200000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 

0501083000 5A Cauliflower 1.200000 1.000 1.000 

0501196000 5A Kohlrabi 1.200000 1.000 1.000 

0502063000 5B Broccoli raab 12.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 

0502117000 5B Collards 12.000000 1.000 1.000 

0502194000 5B Kale 12.000000 1.000 1.000 

0502229000 5B Mustard greens 12.000000 1.000 1.000 

0502318000 5B Rape greens 12.000000 1.000 1.000 

0502389000 5B Turnip, greens 12.000000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.500000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.500000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.080000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.080000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.080000 1.000 1.000 

0801374000 8A Tomatillo 0.900000 1.000 1.000 

0801375000 8A Tomato 0.900000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.900000 1.000 1.000 

0801376000 8A Tomato, paste 0.900000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 0.900000 1.000 1.000 

0801377000 8A Tomato, puree 0.900000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 0.900000 1.000 1.000 

0801378000 8A Tomato, dried 0.900000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.900000 14.300 1.000 

0801379000 8A Tomato, juice 0.900000 1.500 1.000 

0801380000 8A Tomato, Tree 0.900000 1.000 1.000 

0802148000 8BC Eggplant 0.900000 1.000 1.000 

0802234000 8BC Okra 0.900000 1.000 1.000 

0802270000 8B Pepper, bell 0.900000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.900000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.900000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.900000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.900000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.900000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.900000 1.000 1.000 

0901075000 9A Cantaloupe 0.100000 1.000 1.000 

0901187000 9A Honeydew melon 0.100000 1.000 1.000 

0901399000 9A Watermelon 0.100000 1.000 1.000 

0901400000 9A Watermelon, juice 0.100000 1.000 1.000 

0902021000 9B Balsam pear 0.100000 1.000 1.000 

0902088000 9B Chayote, fruit 0.100000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.100000 1.000 1.000 

0902135000 9B Cucumber 0.100000 1.000 1.000 

0902308000 9B Pumpkin 0.100000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.100000 1.000 1.000 

0902356000 9B Squash, summer 0.100000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.100000 1.000 1.000 

0902357000 9B Squash, winter 0.100000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.100000 1.000 1.000 

1304175000 13D Grape 1.500000 1.000 1.000 

1304176000 13D Grape, juice 1.500000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 1.500000 1.000 1.000 

1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 

1901028000 19A Basil, fresh leaves 90.000000 1.000 1.000 

1901028001 19A Basil, fresh leaves-babyfood 90.000000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 20 of 25

1901029000 19A Basil, dried leaves 90.000000 1.000 1.000 

1901029001 19A Basil, dried leaves-babyfood 90.000000 1.000 1.000 

1901102500 19A Chive, dried leaves 90.000000 1.000 1.000 

1901118000 19A Cilantro, leaves 90.000000 1.000 1.000 

1901118001 19A Cilantro, leaves-babyfood 90.000000 1.000 1.000 

1901144000 19A Dillweed 90.000000 1.000 1.000 

1901184000 19A Herbs, other 90.000000 1.000 1.000 

1901184001 19A Herbs, other-babyfood 90.000000 1.000 1.000 

1901202000 19A Lemongrass 90.000000 1.000 1.000 

1901220000 19A Marjoram 90.000000 1.000 1.000 

1901220001 19A Marjoram-babyfood 90.000000 1.000 1.000 

1901249000 19A Parsley, dried leaves 90.000000 1.000 1.000 

1901249001 19A Parsley, dried leaves-babyfood 90.000000 1.000 1.000 

1901334000 19A Savory 90.000000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.211000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.211000 1.000 1.000 

9500177000 O Grape, leaves 1.500000 1.000 1.000 

9500178000 O Grape, raisin 1.500000 1.000 1.000 

9500188000 O Hop 10.000000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 21 of 25

Chronic Food plus Water Results

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for CYAZOFAMID NHANES 2003-2008 2-day

Residue file name: C:\Users\cwalls\Documents\Cassi\HED\cyazofamid\New Use 

2015\dietary\CHRONIC CYAZOFAMID FOOD+WATER 101015.R08

 Adjustment factor #2 NOT used.

Analysis Date 10-14-2015/11:02:37 Residue file dated: 10-14-2015/11:01:15

Reference dose (RfD, Chronic) = .95 mg/kg bw/day

COMMENT 1: Drinking water from PRZM-GW

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.010631 1.1%

Hispanic 0.009996 1.1%

Non-Hisp-White 0.010871 1.1%

Non-Hisp-Black 0.009443 1.0%

Non-Hisp-Other 0.011929 1.3%

Nursing Infants 0.006401 0.7%

Non-Nursing Infants 0.020012 2.1%

Female 13+ PREG 0.009841 1.0%

Children 1-6 0.016595 1.7%

Children 7-12 0.009497 1.0%

Male 13-19 0.007531 0.8%

Female 13-19/NP 0.008080 0.9%

Male 20+ 0.009738 1.0%

Female 20+/NP 0.010962 1.2%

Seniors 55+ 0.010087 1.1%

All Infants 0.015810 1.7%

Female 13-50 0.010422 1.1%

Children 1-2 0.018609 2.0%

Children 3-5 0.015997 1.7%

Children 6-12 0.010164 1.1%

Youth 13-19 0.007809 0.8%

Adults 20-49 0.010452 1.1%

Adults 50-99 0.010256 1.1%

Female 13-49 0.010436 1.1%

-------------------------------------------------------------------------------
Page 22 of 25

Chronic Food Only Residue Input File

Filename: C:\Users\cwalls\Documents\Cassi\HED\cyazofamid\New Use 2015\dietary\CHRONIC 

CYAZOFAMID FOOD only 101015.R08

Chemical: cyazofamid

RfD(Chronic): .95 mg/kg bw/day NOEL(Chronic): 94.8 mg/kg bw/day

RfD(Acute): 1 mg/kg bw/day NOEL(Acute): 100 mg/kg bw/day

Date created/last modified: 10-07-2015/10:45:18 Program ver. 3.16, 03-08-d

Comment: Drinking water from PRZM-GW

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0101078000 1AB Carrot 0.090000 1.000 1.000 

0101078001 1AB Carrot-babyfood 0.090000 1.000 1.000 

0101079000 1AB Carrot, juice 0.090000 1.000 1.000 

0103015000 1CD Arrowroot, flour 0.020000 1.000 1.000 

0103015001 1CD Arrowroot, flour-babyfood 0.020000 1.000 1.000 

0103017000 1CD Artichoke, Jerusalem 0.020000 1.000 1.000 

0103082000 1CD Cassava 0.020000 1.000 1.000 

0103082001 1CD Cassava-babyfood 0.020000 1.000 1.000 

0103139000 1CD Dasheen, corm 0.020000 1.000 1.000 

0103166000 1CD Ginger 0.020000 1.000 1.000 

0103166001 1CD Ginger-babyfood 0.020000 1.000 1.000 

0103167000 1CD Ginger, dried 0.020000 1.000 1.000 

0103296000 1C Potato, chips 0.020000 1.000 1.000 

0103297000 1C Potato, dry (granules/ flakes) 0.020000 1.000 1.000 

0103297001 1C Potato, dry (granules/ flakes)-b 0.020000 1.000 1.000 

0103298000 1C Potato, flour 0.020000 1.000 1.000 

0103298001 1C Potato, flour-babyfood 0.020000 1.000 1.000 

0103299000 1C Potato, tuber, w/peel 0.020000 1.000 1.000 

0103299001 1C Potato, tuber, w/peel-babyfood 0.020000 1.000 1.000 

0103300000 1C Potato, tuber, w/o peel 0.020000 1.000 1.000 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.020000 1.000 1.000 

0103366000 1CD Sweet potato 0.020000 1.000 1.000 

0103366001 1CD Sweet potato-babyfood 0.020000 1.000 1.000 

0103371000 1CD Tanier, corm 0.020000 1.000 1.000 

0103387000 1CD Turmeric 0.020000 1.000 1.000 

0103406000 1CD Yam, true 0.020000 1.000 1.000 

0103407000 1CD Yam bean 0.020000 1.000 1.000 

0301165000 3A Garlic, bulb 2.000000 1.000 1.000 

0301165001 3A Garlic, bulb-babyfood 2.000000 1.000 1.000 

0301237000 3A Onion, bulb 2.000000 1.000 1.000 

0301237001 3A Onion, bulb-babyfood 2.000000 1.000 1.000 

0301238000 3A Onion, bulb, dried 2.000000 9.000 1.000 

0301238001 3A Onion, bulb, dried-babyfood 2.000000 9.000 1.000 

0301338000 3A Shallot, bulb 2.000000 1.000 1.000 

0302103000 3B Chive, fresh leaves 2.000000 1.000 1.000 

0302198000 3B Leek 2.000000 1.000 1.000 

0302239000 3B Onion, green 2.000000 1.000 1.000 

0302338500 3B Shallot, fresh leaves 2.000000 1.000 1.000 

0401005000 4A Amaranth, leafy 10.000000 1.000 1.000 

0401018000 4A Arugula 10.000000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 10.000000 1.000 1.000 

0401133000 4A Cress, garden 10.000000 1.000 1.000 

0401134000 4A Cress, upland 10.000000 1.000 1.000 

0401138000 4A Dandelion, leaves 10.000000 1.000 1.000 

0401150000 4A Endive 10.000000 1.000 1.000 

0401204000 4A Lettuce, head 10.000000 1.000 1.000 

0401205000 4A Lettuce, leaf 10.000000 1.000 1.000 

0401248000 4A Parsley, leaves 10.000000 1.000 1.000 

0401313000 4A Radicchio 10.000000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 23 of 25

0401355000 4A Spinach 10.000000 1.000 1.000 

0401355001 4A Spinach-babyfood 10.000000 1.000 1.000 

0501061000 5A Broccoli 1.200000 1.000 1.000 

0501061001 5A Broccoli-babyfood 1.200000 1.000 1.000 

0501062000 5A Broccoli, Chinese 1.200000 1.000 1.000 

0501064000 5A Brussels sprouts 1.200000 1.000 1.000 

0501069000 5A Cabbage 1.200000 1.000 1.000 

0501071000 5A Cabbage, Chinese, napa 1.200000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 1.200000 1.000 1.000 

0501083000 5A Cauliflower 1.200000 1.000 1.000 

0501196000 5A Kohlrabi 1.200000 1.000 1.000 

0502063000 5B Broccoli raab 12.000000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 12.000000 1.000 1.000 

0502117000 5B Collards 12.000000 1.000 1.000 

0502194000 5B Kale 12.000000 1.000 1.000 

0502229000 5B Mustard greens 12.000000 1.000 1.000 

0502318000 5B Rape greens 12.000000 1.000 1.000 

0502389000 5B Turnip, greens 12.000000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.500000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.500000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.080000 1.000 1.000 

0602033000 6B Bean, cowpea, succulent 0.080000 1.000 1.000 

0602037000 6B Bean, lima, succulent 0.080000 1.000 1.000 

0801374000 8A Tomatillo 0.900000 1.000 1.000 

0801375000 8A Tomato 0.900000 1.000 1.000 

0801375001 8A Tomato-babyfood 0.900000 1.000 1.000 

0801376000 8A Tomato, paste 0.900000 1.000 1.000 

0801376001 8A Tomato, paste-babyfood 0.900000 1.000 1.000 

0801377000 8A Tomato, puree 0.900000 1.000 1.000 

0801377001 8A Tomato, puree-babyfood 0.900000 1.000 1.000 

0801378000 8A Tomato, dried 0.900000 14.300 1.000 

0801378001 8A Tomato, dried-babyfood 0.900000 14.300 1.000 

0801379000 8A Tomato, juice 0.900000 1.500 1.000 

0801380000 8A Tomato, Tree 0.900000 1.000 1.000 

0802148000 8BC Eggplant 0.900000 1.000 1.000 

0802234000 8BC Okra 0.900000 1.000 1.000 

0802270000 8B Pepper, bell 0.900000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.900000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.900000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.900000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.900000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.900000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.900000 1.000 1.000 

0901075000 9A Cantaloupe 0.100000 1.000 1.000 

0901187000 9A Honeydew melon 0.100000 1.000 1.000 

0901399000 9A Watermelon 0.100000 1.000 1.000 

0901400000 9A Watermelon, juice 0.100000 1.000 1.000 

0902021000 9B Balsam pear 0.100000 1.000 1.000 

0902088000 9B Chayote, fruit 0.100000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.100000 1.000 1.000 

0902135000 9B Cucumber 0.100000 1.000 1.000 

0902308000 9B Pumpkin 0.100000 1.000 1.000 

0902309000 9B Pumpkin, seed 0.100000 1.000 1.000 

0902356000 9B Squash, summer 0.100000 1.000 1.000 

0902356001 9B Squash, summer-babyfood 0.100000 1.000 1.000 

0902357000 9B Squash, winter 0.100000 1.000 1.000 

0902357001 9B Squash, winter-babyfood 0.100000 1.000 1.000 

1304175000 13D Grape 1.500000 1.000 1.000 

1304176000 13D Grape, juice 1.500000 1.000 1.000 

1304176001 13D Grape, juice-babyfood 1.500000 1.000 1.000 

1304179000 13D Grape, wine and sherry 1.500000 1.000 1.000 

1901028000 19A Basil, fresh leaves 90.000000 1.000 1.000 

1901028001 19A Basil, fresh leaves-babyfood 90.000000 1.000 1.000 
Cyazofamid Dietary Exposure and Risk Assessment DP Number: 430735

Page 24 of 25

1901029000 19A Basil, dried leaves 90.000000 1.000 1.000 

1901029001 19A Basil, dried leaves-babyfood 90.000000 1.000 1.000 

1901102500 19A Chive, dried leaves 90.000000 1.000 1.000 

1901118000 19A Cilantro, leaves 90.000000 1.000 1.000 

1901118001 19A Cilantro, leaves-babyfood 90.000000 1.000 1.000 

1901144000 19A Dillweed 90.000000 1.000 1.000 

1901184000 19A Herbs, other 90.000000 1.000 1.000 

1901184001 19A Herbs, other-babyfood 90.000000 1.000 1.000 

1901202000 19A Lemongrass 90.000000 1.000 1.000 

1901220000 19A Marjoram 90.000000 1.000 1.000 

1901220001 19A Marjoram-babyfood 90.000000 1.000 1.000 

1901249000 19A Parsley, dried leaves 90.000000 1.000 1.000 

1901249001 19A Parsley, dried leaves-babyfood 90.000000 1.000 1.000 

1901334000 19A Savory 90.000000 1.000 1.000 

9500177000 O Grape, leaves 1.500000 1.000 1.000 

9500178000 O Grape, raisin 1.500000 1.000 1.000 

9500188000 O Hop 10.000000 1.000 1.000 
Page 25 of 25

Chronic Food Only Results

US EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for CYAZOFAMID NHANES 2003-2008 2-day

Residue file name: C:\Users\cwalls\Documents\Cassi\HED\cyazofamid\New Use 

2015\dietary\CHRONIC CYAZOFAMID FOOD only 101015.R08

 Adjustment factor #2 NOT used.

Analysis Date 10-14-2015/11:01:57 Residue file dated: 10-14-2015/11:00:27

Reference dose (RfD, Chronic) = .95 mg/kg bw/day

COMMENT 1: Drinking water from PRZM-GW

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.006213 0.7%

Hispanic 0.005777 0.6%

Non-Hisp-White 0.006326 0.7%

Non-Hisp-Black 0.005797 0.6%

Non-Hisp-Other 0.006837 0.7%

Nursing Infants 0.002404 0.3%

Non-Nursing Infants 0.005318 0.6%

Female 13+ PREG 0.005681 0.6%

Children 1-6 0.010936 1.2%

Children 7-12 0.005813 0.6%

Male 13-19 0.004494 0.5%

Female 13-19/NP 0.004677 0.5%

Male 20+ 0.005621 0.6%

Female 20+/NP 0.006322 0.7%

Seniors 55+ 0.005815 0.6%

All Infants 0.004418 0.5%

Female 13-50 0.006025 0.6%

Children 1-2 0.012236 1.3%

Children 3-5 0.010628 1.1%

Children 6-12 0.006291 0.7%

Youth 13-19 0.004587 0.5%

Adults 20-49 0.006044 0.6%

Adults 50-99 0.005898 0.6%

Female 13-49 0.006044 0.6%

-------------------------------------------------------------------------------