Exhibit31.1

CERTIFICATION PURSUANT TO SECTION 302 OF THESARBANES-OXLEY ACT OF 2002

I, Raymond P. Warrell, Jr., M.D.,certify that:

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|  | 1.  | I have reviewed thisQuarterly Report on Form 10-Q of Genta Incorporated (the‘‘registrant’’); |

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|  | 2.  | Basedon my knowledge, this report does not contain any untrue statement of amaterial fact or omit to state a material fact necessary to make thestatements made, in light of the circumstances under which suchstatements were made, not misleading with respect to the period coveredby this report; |

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|  | 3.  | Based on myknowledge, the financial statements, and other financial informationincluded in this report, fairly present in all material respects thefinancial condition, results of operations and cash flows of theregistrant as of, and for, the periods presented in thisreport; |

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|  | 4.  | The registrant’s othercertifying officer and I are responsible for establishing andmaintaining disclosure controls and procedures as defined in ExchangeAct Rules 13a-15(e) and 15d-15(e) and internal control over financialreporting as defined in Exchange Act Rules 13a-15(f) and 15d-15(f) forthe registrant and we have: |

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|  | a)  | Designedsuch disclosure controls and procedures, or caused such disclosurecontrols and procedures to be designed under our supervision, to ensurethat material information relating to the registrant, including itsconsolidated subsidiaries, is made known to us by others within thoseentities, particularly during the period in which this report is beingprepared; |

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|  | b)  | Designed such internalcontrol over financial reporting, or caused such internal control overfinancial reporting to be designed under our supervision, to providereasonable assurance regarding the reliability of financial reportingand the preparation of financial statements for external purposes inaccordance with generally accepted accountingprinciples; |

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|  | c)  | Evaluated theeffectiveness of the registrant’s disclosure controls andprocedures and presented in this report our conclusions about theeffectiveness of the disclosure controls and procedures, as of the endof the period covered by this report based on such evaluation;and |

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|  | d)  | Disclosed in this report anychange in the registrant’s internal control over financialreporting that occurred during the registrant’s most recentfiscal quarter that has materially affected, or is reasonably likely tomaterially affect, the registrant’s internal control overfinancial reporting; and |

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|  | 5.  | Theregistrant’s other certifying officer and I have disclosed,based on our most recent evaluation of internal control over financialreporting, to the registrant’s auditors and the audit committeeof the registrant’s board of directors (or persons performingthe equivalent functions): |

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|  | a)  | Allsignificant deficiencies and material weaknesses in the design oroperation of internal control over financial reporting which arereasonably likely to adversely affect the registrant’s abilityto record, process, summarize and report financial information;and |

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|  | b)  | Any fraud, whether or notmaterial, that involves management or other employees who have asignificant role in the registrant’s internal control overfinancialreporting. |

Date:    August8,  2006

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| /s/RAYMOND P. WARRELL, JR., M.D. |
| Name:                            |  |  | Raymond P. Warrell, Jr., M.D.       |
| Title:                           |  |  | Chairman and Chief ExecutiveOfficer |
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