Exhibit 31.1

CERTIFICATION
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Raymond P.
Warrell, Jr., M.D., certify that:

|1. |  | I
have reviewed this  Quarterly  Report on Form 10-Q of Genta  Incorporated (the registrant);
|-- |  | -----------------------------------------------------------------------------------------------

|2. |  | Based
on my  knowledge,  this  report  does not  contain  any  untrue  statement  of a
material  fact or  omit  to  state a  material  fact  necessary  to make the  statements
made,  in  light of the  circumstances  under which such statements were  made,  not
misleading  with respect to the period covered by  this report;
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|3. |  | Based
on my knowledge,  the financial  statements,  and other  financial  information  included
in  this  report,  fairly  present in all  material  respects the  financial  condition,
results of  operations  and cash flows of the  registrant  as  of, and for, the periods
presented in this report;
|-- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|4. |  | The
registrants  other  certifying  officer  and  I  are  responsible  for
establishing  and  maintaining  disclosure  controls  and  procedures  (as defined in
Exchange  Act Rules  13a-15(e) and 15d-15(e)) for the registrant and we have:
|-- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|a) |  | Designed
such disclosure  controls and procedures,  or caused  such  disclosure  controls  and
procedures  to  be  designed  under our  supervision,  to  ensure  that  material
information  relating to the  registrant,  including its  consolidated  subsidiaries,  is
made  known  to  us  by  others  within  those  entities,  particularly  during  the
period  in  which  this  report is being prepared;
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|b) |  | [Reserved]
|-- |  | ----------

|c) |  | Evaluated
the  effectiveness of the  registrants  disclosure  controls  and  procedures  and
presented  in  this  report our conclusions  about the  effectiveness of  the disclosure
controls and procedures,  as of the  end of the period  covered by this report  based on
such evaluation; and  d)  Disclosed  in this  report  any  change  in the  registrants
internal  control  over  financial  reporting  that  occurred  during  the  registrants
most  recent  fiscal quarter that has materially affected,  or is  reasonably  likely  to
materially  affect,  the  registrants  internal  control  over  financial
reporting; and
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|5. |  | The
registrants  other  certifying  officer  and  I  have  disclosed,  based on our
most recent  evaluation  of internal  control  over  financial  reporting,  to  the
registrants  auditors and the audit  committee of the  registrants  board  of
directors  (or  persons  performing  the  equivalent  functions):
|-- |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|a) |  | All
significant  deficiencies and material  weaknesses in the  design  or  operation  of
internal  control  over  financial  reporting which are reasonably likely to  adversely
affect  the  registrants  ability  to  record,  process,  summarize  and report
financial  information; and
|-- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|b) |  | Any
fraud, whether or not material,  that involves management  or other  employees who have a
significant  role in  the  registrants  internal  control over financial  reporting.
|-- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Date:  May 10,
2005

|/s/ RAYMOND P. WARRELL, JR., M.D.
|---------------------------------
|Name:                            
|Title:                           

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