Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

DMA Salt of Quinclorac (PC Code 028974) 

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF CHEMICAL SAFETY

AND POLLUTION PREVENTION

MEMORANDUM

DATE: September 24, 2012

SUBJECT: Quinclorac and the Dimethylamine (DMA) Salt of Quinclorac. Acute and

Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk 

Assessments for the Section 3 Registration Action on Rhubarb and Low Growing 

Berry except Strawberry, Subgroup 13-07H and the Registration Review Action. 

PC Code: 128974 and 028974 DP Barcodes: D404795 and D404914

Decision Numbers: 459055 and 468877 Registration Number: 42750-169

Petition Number: 1E7957 Regulatory Action: Section 3 and 

Registration Review

Assessment Type: Single Chemical/Aggregate Case Number: 7222

TXR Number: Not Applicable CAS Number: 84087-01-4

MRID Number: Not Applicable 40CFR §180. 463

FROM: Bonnie Cropp-Kohlligian, Environmental Scientist

Risk Assessment Branch IV, Health Effects Division (HED) (7509P)

THROUGH: Thurston Morton, Chemist, Senior Scientist

Risk Assessment Branch IV, HED (7509P)

and

Douglas Dotson, Ph.D., Chemist

Ideliz Negrón-Encarnación, Ph.D., Chemist

Dietary Exposure Science Advisory Council (DESAC), HED (7509P)

TO: Sidney Jackson and Barbara Madden, PM#5

 RIMUERB, Registration Division (RD) (7505P)

and

 Erik Kraft and Kable Davis, PM#25

 Herbicide Branch, RD (7505P)

and

Wilhelmina Livingston, RM#60

Pesticide Reevaluation Division (PRD) (7508P)
Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

DMA Salt of Quinclorac (PC Code 028974) 

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Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments 

were conducted using the Dietary Exposure Evaluation Model DEEM-FCID, Version 3.16 which 

uses food consumption data from the U.S. Department of Agriculture’s National Health and 

Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). This dietary

survey was conducted from 2003 to 2008. These analyses were performed to support the Section 

3 request for quinclorac uses on rhubarb and low growing berry, except strawberry, subgroup 13-

07H and to support Registration Review for quinclorac and the dimethylamine (DMA) salt of 

quinclorac. All registered, pending and proposed uses of quinclorac and the DMA salt of 

quinclorac, as of the date of this memorandum, are included in these assessments. 

Tolerances have been established for quinclorac (40CFR §180.463[a]) in livestock and cereal 

grain commodities. HED has determined that the use of the DMA salt of quinclorac on cereal 

grains will not affect the established tolerances for quinclorac on rice, grain sorghum, and wheat.

The residue of concern (ROC), for both tolerance enforcement and risk assessment, is the parent 

compound, quinclorac. Both the acute and chronic assessments are highly conservative, and 

assume 100% crop treated (%CT), along with tolerance-level residues for all agricultural 

commodities. Default processing factors from DEEM 7.81 were used (for dried beef and 

cranberry juice) in the analyses. Screening-level Tier I modeling was used to estimate drinking 

water concentrations.

The acute (food + water) dietary risk estimate at the 95th percentile of exposure is 1.6% of the 

acute population adjusted dose (aPAD) for females age 13 to 49. This is the only population 

subgroup for which an acute endpoint was selected. 

The chronic (food + water) dietary risk estimates are less than or equal to 8.9% of the chronic 

population adjusted dose (cPAD) for all population subgroups. All Infants < 1 year of age is the 

most highly-exposed subgroup, utilizing 8.9% of the cPAD, while the general US population 

utilizes 3.6% of the cPAD. 

Generally, the Agency is concerned when risk estimates exceed 100% of the PAD. All acute and 

chronic dietary risk estimates for quinclorac are below HED’s level of concern. 

 

Quinclorac was classified in 1992 by the HED Cancer Peer Review committee (CPRC) as a 

group D carcinogen - not classifiable as to human carcinogenicity- based on recommendation by 

the EPA Scientific Advisory Panel (TXR# 0010416). This classification was based on equivocal 

increase in the incidence of one type of benign tumor (pancreatic acinar cell adenomas) in only

one sex and one species of animals (male Wistar rats). A quantification of cancer risk is not 

warranted because the chronic RfD will adequately account for all chronic effects, including the 

observed adenomas, likely to result from exposure to quinclorac. 
Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

DMA Salt of Quinclorac (PC Code 028974) 

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1. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to point 

of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References which discuss the acute and chronic risk assessments in more detail 

are available on the EPA/pesticides web site: “Available Information on Assessing Exposure 

from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for quinclorac was conducted by W. Drew (6/2/09, DP# 

363872).

2. Residue Information

Reference Memo: DP#s 397719, 404569, 404569; 9/6/12; S. Hummel (Residue Chemistry Summary Document)

Reference: Quinclorac Summary Document Registration Review: Initial Docket December 2007 (bioaccumulation)

The qualitative nature of quinclorac residues in plants is considered adequately understood for 

the currently registered and proposed uses, based on rice, grain sorghum, and wheat metabolism 

studies. The qualitative nature of quinclorac residues in livestock is considered adequately 

understood based on goat and poultry metabolism studies. In each of these studies, quinclorac 

was the major residue identified in each commodity. Based on the above studies, HED has 

concluded that parent is the only residue of concern in plant and livestock commodities for 

purposes of the tolerance expression and risk assessment. 

Permanent tolerances have been established for quinclorac (40CFR §180.463[a]) in/on livestock 

and cereal grain commodities. A time-limited tolerance for a Section 18 emergency exemption 

has been established for quinclorac (40CFR §180.463[b]) in/in cranberry at 15.0 ppm 

(expiration/revocation date 12/31/12). 

Based on rice, grain sorghum, and wheat side-by-side field trial data comparing residue levels of 

quinclorac and the dimethylamine (DMA) salt of quinclorac and a comparative study of the 

dissociation behavior of quinclorac and the DMA salt of quinclorac, HED determined that the 

use of the DMA salt of quinclorac on cereal grains will not affect the established tolerances for 

quinclorac on rice, grain sorghum, and wheat (DP#s 378709 and 378710, J. Stokes, 3/25/11).

Under PP#1E7957, Interregional Research Project Number 4 (IR-4) is proposing new uses for 

quinclorac on rhubarb and low growing berry, except strawberry, crop subgroup 13-07H. In 
Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

DMA Salt of Quinclorac (PC Code 028974) 

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conjunction with these uses, HED is recommending the tolerances below for residues of 

quinclorac, including its metabolites and degradates. 

Rhubarb............................................................................................0.5 ppm

Low growing berry, except strawberry, crop subgroup 13-07H......1.5 ppm

Cranberry is the representative commodity for low growing berry, except strawberry, crop 

subgroup 13-07H. Since the proposed Section 3 use on low growing berry, except strawberry, 

crop subgroup 13-07H is essentially the same as the Section 18 use on cranberry, HED is 

recommending for the revocation of the currently established time-limited tolerance for residues 

of quinclorac in/on cranberry (15.0 ppm). 

Under Registration Review of currently registered uses of quinclorac and the DMA salt of 

quinclorac, HED is recommending no changes to the currently established tolerances in/on the 

food commodities below for residues of quinclorac, including its metabolites and degradates. 

Barley, grain.....................................................................................2.0 ppm

Rice, bran .......................................................................................15.0 ppm

Rice, grain........................................................................................5.0 ppm

Sorghum, grain, grain ......................................................................6.0 ppm

Wheat, germ.....................................................................................0.75 ppm

Wheat, grain.....................................................................................0.5 ppm

Egg ...................................................................................................0.05 ppm

Fat of Cattle, Goat, Horse, Sheep ....................................................0.7 ppm

Fat of Poultry ...................................................................................0.05 ppm

Meat of Cattle, Goat, Hog, Horse, Poultry, Sheep...........................0.05 ppm

Meat byproducts of Cattle, Goat, Horse, Sheep...............................1.5 ppm

Milk..................................................................................................0.05 ppm

Under Registration Review of currently registered uses of quinclorac and the DMA salt of 

quinclorac, HED is recommending lowering the currently established tolerances in/on the food 

commodities below for residues of quinclorac, including its metabolites and degradates for the 

purposes of harmonization.

Hog, fat .................................................................... lowered from 0.7 ppm to 0.05 ppm

Hog, meat byproducts...............................................lowered from 1.5 ppm to 0.05 ppm

Poultry, meat byproducts..........................................lowered from 0.1 ppm to 0.05 ppm
Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

DMA Salt of Quinclorac (PC Code 028974) 

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Residues in Fish

At this time, residues in fish are not deemed an important issue for quinclorac and were not 

included in the assessment. The USDA Pesticide Data Program (PDP) did not analyze for 

residues of quinclorac in catfish tested 2008-2010. No tolerances are currently established for 

residues of quinclorac in fish. However, the currently registered/proposed uses on rice and 

cranberry are aquatic crops, and HED has determined that label restrictions are needed regarding 

the uses of quinclorac-treated rice and cranberry fields for aquaculture. Alternatively, HED has 

suggested that the petitioner could determine residues of quinclorac in catfish and crayfish raised 

in quinclorac-treated fields and propose tolerances for these commodities, if necessary.

According to the Quinclorac Summary Document Registration Review: Initial Docket December 

2007, bioaccumulation in fish is not expected according to the acceptable fish accumulation 

study, which showed that after 28 days of exposure, quinclorac did not accumulate in channel 

catfish. No bioconcentration factor was reported. Furthermore, the octanol/water partition 

coefficient (KOW) of 0.266 also suggests that quinclorac has low potential to bioaccumulate. 

3. Drinking Water Data

The quinclorac drinking water estimates used in these dietary risk assessments were provided by

EFED (DP# 397720, M. Lowit/N. Andrews, 8/9/12 and DP# 405093, M. Lowit/N.Andrews, 

9/14/12), and incorporated directly into the dietary assessments. Water residues were 

incorporated in DEEM-FCID via entry into the food categories “water, direct, all sources” and 

“water, indirect, all sources.” The estimated drinking water concentrations (EDWCs) from 

existing and proposed uses of quinclorac for both acute and chronic scenarios in ground and 

surface water are 0.029 ppm and 0.511 ppm, respectively. 

Rice (labeled for a single application of 0.5 lb ai/A) was identified as the use resulting in the 

highest EDWCs for surface water. Because the use on rice involves flooding (for which the 

current Tier II model is not parameterized), the surface water EDWCs were assessed using a Tier 

I Rice Model, Version 1.0 (May 8, 2007). Turf grass was identified as the use resulting in the 

highest EDWCs for ground water. The EDWC in ground water was assessed using the Tier I 

Screening Concentration in Ground Water (SCI-GROW, Version 2.3) model. These models, and 

their descriptions, are available at the EPA internet website via the web link,

http://www.epa.gov/oppefed1/models/water/. No surface or ground water monitoring data were 

available for quinclorac. 

4. Percent Crop Treated Information

The acute and chronic assessments are based on the assumption that 100% of all commodities 

with tolerances will be treated.
Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

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5. DEEM-FCID Program and Consumption Information

Quinclorac acute and chronic dietary exposure assessments were conducted using the Dietary

Exposure Evaluation Model software with the Food Commodity Intake Database DEEM-FCID, 

Version 3.16, which incorporates consumption data from USDA’s National Health and Nutrition 

Examination Survey, What We Eat in America, (NHANES/WWEIA). This dietary survey was 

conducted from 2003 to 2008. The data are based on the reported consumption of more than 

20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) 

are linked to EPA-defined food commodities (e.g. apples, peeled fruit - cooked; fresh or N/S; 

baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation 

files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption 

data are averaged for the entire U.S. population and within population subgroups, but for acute 

exposure assessment are retained as individual consumption events. Based on analysis of the 

2003-2008 WWEIA consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 years 

old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for all tiers of analysis. However, for tiers 1 and 2, any significant 

differences in user vs. per capita exposure and risk are specifically identified and noted in the 

risk assessment.
Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

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6. Toxicological Information

An appropriate endpoint attributable to a single exposure to assess dietary exposure for the 

general populations including infants and children was not available from the oral toxicity

studies including the rat and rabbit developmental toxicity studies.

An acute dietary POD of 200 mg/kg (NOAEL) for the sub-population females 13-49 years old 

was selected from a rabbit developmental toxicity study based on increased rate of resorptions

and post-implantation loss, a decrease in the number of live fetuses, and reduced fetal body

weight seen at 600 mg/kg/day. A UF 100x (10x for intraspecies variation, 10x for interspecies 

extrapolation and a 1x FQPA safety factor) was applied to the dose to obtain an acute reference 

dose/population adjusted dose (aRfD/aPAD) of 2.0 mg/kg.

A chronic dietary POD of 38 mg/kg/day (NOAEL) was selected for the general population from 

a carcinogenicity study in mice based on effects on body weight. A UF 100x (10x for 

intraspecies variation, 10x for interspecies extrapolation and a 1x FQPA factor) was applied to 

the dose to obtain a chronic reference dose/population adjusted dose (cRfD/cPAD) of 0.38

mg/kg/day.

Quinclorac was classified in 1992 by the HED Cancer Peer Review committee (CPRC) as a 

group D carcinogen - not classifiable as to human carcinogenicity- based on recommendation by 

the EPA Scientific Advisory Panel (TXR# 0010416). This classification was based on equivocal 

increase in the incidence of one type of benign tumor (pancreatic acinar cell adenomas) in only

one sex and one species of animals (male Wistar rats). A quantification of cancer risk is not 

warranted because the chronic RfD will adequately account for all chronic effects, including the 

observed adenomas, likely to result from exposure to quinclorac. There was no evidence of 

carcinogenicity in mice or female rats.

Toxicological doses and endpoints for dietary human health risk assessments for quinclorac are 

presented below in Table 1. For detailed information, please refer to the forthcoming human 

health risk assessment. 
Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

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TABLE 1. Summary of Quinclorac Toxicological Doses and Endpoints for Use in Dietary Human Health 

Risk Assessments.

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, 

Level of 

Concern 

for Risk 

Assessment

Study and Toxicological Effects

Acute 

Dietary 

(General 

Population, 

including 

Infants and 

Children)

Not applicable. An endpoint for acute dietary exposure to the general population was not selected 

because there was no available endpoint that was appropriate for this scenario (effects observed in 

the available studies are presumed to require more than one exposure).

Acute 

Dietary

(Females 13-

49 years of 

age)

NOAEL 

(developmental) 

= 200 

mg/kg/day

UFA= 10x

UFH=10x

FQPA SF= 1x

aRfD = 2.0

mg/kg/day

aPAD = 2.0 

mg/kg/day

Developmental toxicity study in rabbits 

(MRID# 41063525 and 41680501) 

Developmental toxicity LOAEL = 600 

mg/kg/day based on increased early 

resorptions and postimplantation loss, 

decreased live fetuses, decreased fetal 

body weight. These fetal effects are 

presumed to occur after a single dose.

Chronic 

Dietary (All 

Populations)

NOAEL= 37.5

mg/kg/day

UFA= 10x

UFH=10x

FQPA SF= 1x

cRfD = 0.38

mg/kg/day

cPAD = 

0.38 

mg/kg/day

Carcinogenicity study in mice MRID # 

41063523)

LOAEL = 150 mg/kg/day based on 

decreased body weight.

Cancer (oral, 

dermal, 

inhalation)

Available carcinogenicity studies indicate that there was equivocal evidence of an increase in the 

incidence of pancreatic acinar cell adenomas in the male rat, but no treatment-associated increases 

in tumors were observed in female rats or in mice. A quantification of cancer risk is not warranted 

because the chronic RfD of 0.375 mg/kg/day is approximately 1200-fold lower than the dose (487 

mg/kg/day) that induced the benign pancreatic tumors. Thus, the chronic RfD will adequately 

account for all chronic effects, including the observed adenomas, likely to result from exposure to 

quinclorac. 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in 

sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = 

population adjusted dose (a = acute, c = chronic). RfD = reference dose. 
Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

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7. Results/Discussion

HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM-FCID analyses 

estimate the dietary exposure of the US population and various population subgroups. The 

results of the acute analysis for females 13-49 are summarized in Table 2 (below). As shown in 

Table 2, the risk estimates associated with acute dietary exposure to quinclorac are below HED’s 

LOC. 

The acute dietary risk estimate at the 95th percentile of exposure is 1.6% of the aPAD for females 

age 13 to 49. This is the only population subgroup for which an acute endpoint was selected. 

TABLE 2. Summary of Acute Dietary Exposure and Risk Estimates for Quinclorac. 

Population Subgroup

[Years of Age]

DEEM Acute Dietary Analysis (95th Percentile)

aPAD (mg/kg/day) Exposure Estimate 

(mg/kg/day)

% aPAD

Females [13-49] 2.0 0.032108 1.6

* NA = Not Applicable. An appropriate acute endpoint was not identified for these population subgroups. 

The chronic dietary risk estimates are less than or equal to 8.9% of the chronic population

adjusted dose (cPAD) for all population subgroups as shown in Table 3 (below). All Infants 

<1year of age are the most highly-exposed subgroup, utilizing 8.9% of the cPAD, while the 

general US population utilizes 3.6% of the cPAD. 

TABLE 3. Summary of Chronic Dietary Exposure and Risk Estimates for Quinclorac. 

Population Subgroup*

[Years of Age]

DEEM Chronic Dietary Analysis

cPAD (mg/kg/day) Exposure Estimate

(mg/kg/day)

% cPAD

General US Population 0.38 0.013728 3.6

All Infants [<1] 0.033999 8.9

Children [1-2] 0.023500 6.2

Children [3-5] 0.019280 5.1

Children [6-12] 0.013431 3.5

Youth [13-19] 0.010195 2.7

Adults [20-49] 0.013614 3.6

Adults [50-99] 0.012525 3.3

Females [13-49] 0.012893 3.4

* Values for the population subgroup with the highest risk are in bold type. 
Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

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8. Characterization of Inputs/Outputs

This assessment is based on tolerance level residues in all agricultural commodities, assumes that 

all crops with existing or proposed tolerances are treated to a level of 100% and makes use of 

DEEM default processing factors. In addition, Tier I drinking water estimates were used. These 

assumptions result in highly conservative, health-protective estimates of dietary exposure and 

risk. 

9. Conclusions

Generally, the Agency is concerned when dietary risk estimates exceed 100% of the PAD. All 

acute and chronic dietary risk estimates for quinclorac are below HED’s level of concern. 

 

10. List of Attachments

Attachment 1. Quinclorac Residues Used for Acute and Chronic Dietary Exposure Estimates.

Attachment 2. Summary of the Acute Dietary Exposure and Risk Estimates for Quinclorac.

Attachment 3. Summary of the Chronic Dietary Exposure and Risk Estimates for Quinclorac. 
Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

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Attachment 1. Quinclorac Residues Used for Acute and Chronic Dietary Exposure 

Estimates.

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Acute and Chronic analysis for QUINCLORAC

Residue file name: QUINCLORACDEEM092412INPUT.R08

 Adjust. #2 used

Analysis Date 09-24-2012 Residue file dated: 09-24-2012/10:44:12

Acute Reference dose (RfD) = 2.0 mg/kg bw/day (Females 13-49 only)

Chronic Reference dose (RfD) = 0.38 mg/kg bw/day

Comment: Tolerances Used for Acute and Chronic Analyses

----------------------------------------------------------------------------------

Food Crop Residue Adj.Factors

EPA Code Grp Food Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------

1500025000 15 Barley, pearled barley 2.000000 1.000 1.000 

1500025001 15 Barley, pearled barley-babyfood 2.000000 1.000 1.000 

1500026000 15 Barley, flour 2.000000 1.000 1.000 

1500026001 15 Barley, flour-babyfood 2.000000 1.000 1.000 

1500027000 15 Barley, bran 2.000000 1.000 1.000 

3100044000 31 Beef, meat 0.050000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.050000 1.920 1.000 

3100046000 31 Beef, meat byproducts 1.500000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 1.500000 1.000 1.000 

3100047000 31 Beef, fat 0.700000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.700000 1.000 1.000 

3100048000 31 Beef, kidney 1.500000 1.000 1.000 

3100049000 31 Beef, liver 1.500000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 1.500000 1.000 1.000 

1302057000 13B Blueberry 1.500000 1.000 1.000 

1302057001 13B Blueberry-babyfood 1.500000 1.000 1.000 

4000093000 40 Chicken, meat 0.050000 1.000 1.000 

4000093001 40 Chicken, meat-babyfood 0.050000 1.000 1.000 

4000094000 40 Chicken, liver 0.050000 1.000 1.000 

4000095000 40 Chicken, meat byproducts 0.050000 1.000 1.000 

4000095001 40 Chicken, meat byproducts-babyfoo 0.050000 1.000 1.000 

4000096000 40 Chicken, fat 0.050000 1.000 1.000 

4000096001 40 Chicken, fat-babyfood 0.050000 1.000 1.000 

4000097000 40 Chicken, skin 0.050000 1.000 1.000 

4000097001 40 Chicken, skin-babyfood 0.050000 1.000 1.000 

1307130000 13G Cranberry 1.500000 1.000 1.000 

1307130001 13G Cranberry-babyfood 1.500000 1.000 1.000 

1307131000 13G Cranberry, dried 1.500000 1.000 1.000 

1307132000 13G Cranberry, juice 1.500000 1.100 1.000 

1307132001 13G Cranberry, juice-babyfood 1.500000 1.100 1.000 

7000145000 70 Egg, whole 0.050000 1.000 1.000 

7000145001 70 Egg, whole-babyfood 0.050000 1.000 1.000 

7000146000 70 Egg, white 0.050000 1.000 1.000 

7000146001 70 Egg, white (solids)-babyfood 0.050000 1.000 1.000 

7000147000 70 Egg, yolk 0.050000 1.000 1.000 

7000147001 70 Egg, yolk-babyfood 0.050000 1.000 1.000 

3200169000 32 Goat, meat 0.050000 1.000 1.000 

3200170000 32 Goat, meat byproducts 1.500000 1.000 1.000 

3200171000 32 Goat, fat 0.700000 1.000 1.000 

3200172000 32 Goat, kidney 1.500000 1.000 1.000 

3200173000 32 Goat, liver 1.500000 1.000 1.000 

3300189000 33 Horse, meat 0.050000 1.000 1.000 

3800221000 38 Meat, game 0.050000 1.000 1.000 

3600222000 36 Milk, fat 0.050000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.050000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.050000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

3600224000 36 Milk, water 0.050000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.050000 1.000 1.000 
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3600225001 36 Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

3400290000 34 Pork, meat 0.050000 1.000 1.000 

3400290001 34 Pork, meat-babyfood 0.050000 1.000 1.000 

3400291000 34 Pork, skin 0.050000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.050000 1.000 1.000 

3400292001 34 Pork, meat byproducts-babyfood 0.050000 1.000 1.000 

3400293000 34 Pork, fat 0.050000 1.000 1.000 

3400293001 34 Pork, fat-babyfood 0.050000 1.000 1.000 

3400294000 34 Pork, kidney 0.050000 1.000 1.000 

3400295000 34 Pork, liver 0.050000 1.000 1.000 

6000301000 60 Poultry, other, meat 0.050000 1.000 1.000 

6000302000 60 Poultry, other, liver 0.050000 1.000 1.000 

6000303000 60 Poultry, other, meat byproducts 0.050000 1.000 1.000 

6000304000 60 Poultry, other, fat 0.050000 1.000 1.000 

6000305000 60 Poultry, other, skin 0.050000 1.000 1.000 

3900312000 39 Rabbit, meat 0.050000 1.000 1.000 

0402322000 4B Rhubarb 0.500000 1.000 1.000 

1500323000 15 Rice, white 5.000000 1.000 1.000 

1500323001 15 Rice, white-babyfood 5.000000 1.000 1.000 

1500324000 15 Rice, brown 5.000000 1.000 1.000 

1500324001 15 Rice, brown-babyfood 5.000000 1.000 1.000 

1500325000 15 Rice, flour 5.000000 1.000 1.000 

1500325001 15 Rice, flour-babyfood 5.000000 1.000 1.000 

1500326000 15 Rice, bran 15.000000 1.000 1.000 

1500326001 15 Rice, bran-babyfood 15.000000 1.000 1.000 

3500339000 35 Sheep, meat 0.050000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 1.500000 1.000 1.000 

3500341000 35 Sheep, fat 0.700000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.700000 1.000 1.000 

3500342000 35 Sheep, kidney 1.500000 1.000 1.000 

3500343000 35 Sheep, liver 1.500000 1.000 1.000 

1500344000 15 Sorghum, grain 6.000000 1.000 1.000 

1500345000 15 Sorghum, syrup 6.000000 1.000 1.000 

1500381000 15 Triticale, flour 0.500000 1.000 1.000 

1500381001 15 Triticale, flour-babyfood 0.500000 1.000 1.000 

5000382000 50 Turkey, meat 0.050000 1.000 1.000 

5000382001 50 Turkey, meat-babyfood 0.050000 1.000 1.000 

5000383000 50 Turkey, liver 0.050000 1.000 1.000 

5000383001 50 Turkey, liver-babyfood 0.050000 1.000 1.000 

5000384000 50 Turkey, meat byproducts 0.050000 1.000 1.000 

5000384001 50 Turkey, meat byproducts-babyfood 0.050000 1.000 1.000 

5000385000 50 Turkey, fat 0.050000 1.000 1.000 

5000385001 50 Turkey, fat-babyfood 0.050000 1.000 1.000 

5000386000 50 Turkey, skin 0.050000 1.000 1.000 

5000386001 50 Turkey, skin-babyfood 0.050000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.511000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.511000 1.000 1.000 

1500401000 15 Wheat, grain 0.500000 1.000 1.000 

1500401001 15 Wheat, grain-babyfood 0.500000 1.000 1.000 

1500402000 15 Wheat, flour 0.500000 1.000 1.000 

1500402001 15 Wheat, flour-babyfood 0.500000 1.000 1.000 

1500403000 15 Wheat, germ 0.750000 1.000 1.000 

1500404000 15 Wheat, bran 0.500000 1.000 1.000 

1500405000 15 Wild rice 5.000000 1.000 1.000 
Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

DMA Salt of Quinclorac (PC Code 028974) 

Page 13 of 14

Attachment 2. Summary of the Acute Dietary Exposure and Risk Estimates for 

Quinclorac.

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for QUINCLORAC NHANES 2003-2008 2-Day

Residue file name: QUINCLORACDEEM092412INPUT.R08 Adjustment factor #2 used.

Analysis Date: 09-24-2012/10:46:50 Residue file dated: 09-24-2012/10:44:12

RAC/FF intake summed over 24 hours

Run Comment: Acute is for Females 13-49 only.

===============================================================================

Summary calculations--per capita:

 95th Percentile 99th Percentile 99.9th Percentile

Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- --------

Female 13-49:

 0.032108 1.61 0.043819 2.19 0.060306 3.02 
Quinclorac (PC Code 128974) Dietary Exposure and Risk Assessment DP#s 404795 and 404914

DMA Salt of Quinclorac (PC Code 028974) 

Page 14 of 14

Attachment 3. Summary of the Chronic Dietary Exposure and Risk Estimates for Quinclorac.

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for QUINCLORAC NHANES 2003-2008 2-day

Residue file name: QUINCLORACDEEM092412INPUT.R08

 Adjustment factor #2 used.

Analysis Date 09-24-2012/10:45:30 Residue file dated: 09-24-2012/10:44:12

Reference dose (RfD, Chronic) = .38 mg/kg bw/day

COMMENT 1: 

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.013728 3.6%

Hispanic 0.013922 3.7%

Non-Hisp-White 0.013714 3.6%

Non-Hisp-Black 0.011683 3.1%

Non-Hisp-Other 0.018298 4.8%

Nursing Infants 0.013500 3.6%

Non-Nursing Infants 0.043154 11.4%

Female 13+ PREG 0.012415 3.3%

Children 1-6 0.020422 5.4%

Children 7-12 0.012785 3.4%

Male 13-19 0.009941 2.6%

Female 13-19/NP 0.010453 2.8%

Male 20+ 0.013090 3.4%

Female 20+/NP 0.013237 3.5%

Seniors 55+ 0.012155 3.2%

All Infants 0.033999 8.9%

Female 13-50 0.012889 3.4%

Children 1-2 0.023500 6.2%

Children 3-5 0.019280 5.1%

Children 6-12 0.013431 3.5%

Youth 13-19 0.010195 2.7%

Adults 20-49 0.013614 3.6%

Adults 50-99 0.012525 3.3%

Female 13-49 0.012893 3.4%

-------------------------------------------------------------------------------