Exhibit 21

Pharmaceutical Product Development, Inc., and Subsidiaries

Subsidiaries

The subsidiaries of Pharmaceutical Product Development, Inc., as of February 28, 2006, are as follows:



|    |  |                                                           |  |                                             
|--- |  | --------------------------------------------------------- |  | --------------------------------------------
|    |  | Name of Subsidiary                                        |  | Jurisdiction of Incorporationor Organized in
|1.  |  | Applied Bioscience International, LLC                     |  | Delaware                                    
|2.  |  | CSS Informatics, Inc.                                     |  | California                                  
|3.  |  | PPD Global Central Labs, LLC                              |  | Kentucky                                    
|4.  |  | Piedmont Research Center, LLC                             |  | North Carolina                              
|5.  |  | PPD Aeronautics, LLC                                      |  | North Carolina                              
|6.  |  | PPD Virtual, Inc.                                         |  | North Carolina                              
|7.  |  | APBI Finance Corporation                                  |  | Delaware                                    
|8.  |  | APBI Holdings, LLC                                        |  | North Carolina                              
|9.  |  | Development Partners, LLC                                 |  | Delaware                                    
|10. |  | PPD GP, LLC                                               |  | Delaware                                    
|11. |  | PPD Holdings, LLC                                         |  | Delaware                                    
|12. |  | PPD UK Holdings Ltd.                                      |  | United Kingdom                              
|13. |  | SARCO, LLC                                                |  | Delaware                                    
|14. |  | Genupro, Inc.                                             |  | North Carolina                              
|15. |  | PPD Development, LP                                       |  | Texas                                       
|16. |  | ATP, LLC                                                  |  | North Carolina                              
|17. |  | PPD Online Marketing and Education, Inc.                  |  | Delaware                                    
|18. |  | PPD Medical Device, Inc.                                  |  | Delaware                                    
|19. |  | Pharmaco Investments, Inc.                                |  | Delaware                                    
|20. |  | PPD International Holdings, Inc.                          |  | Delaware                                    
|21. |  | PPD France SNC                                            |  | France                                      
|22. |  | PPD Scandinavia AB                                        |  | Sweden                                      
|23. |  | Pharmaceutical Product Development Spain SL               |  | Spain                                       
|24. |  | PPD do Brasil-Suporte a Pesquisa Clinica Ltda.            |  | Brazil                                      
|25. |  | PPD Argentina, S.A.                                       |  | Argentina                                   
|26. |  | PPD International Holdings, Inc. Y Compania Limitada      |  | Chile                                       
|27. |  | Pharmaceutical Product Development South Africa (PTY) LTD |  | South Africa                                
|28. |  | PPD Canada, LTD.                                          |  | Canada                                      
|29. |  | PPD Australia PTY LTD                                     |  | Australia                                   
|30. |  | PPD International Holdings GmbH                           |  | Germany                                     
|31. |  | PPD Germany GmbH                                          |  | Germany                                     
|32. |  | PPD Poland Sp. zo.o                                       |  | Poland                                      
|33. |  | PPD Czech Republic, s.r.o.                                |  | Czech Republic                              
|34. |  | PPD Germany GmbH & co. KG                                 |  | Germany                                     
|35. |  | PPD Hungary Research and Development LTD                  |  | Hungary                                     
|36. |  | PPD Italy S.r.l.                                          |  | Italy                                       
|37. |  | PPD Mexico, S.A. de C.V.                                  |  | Mexico                                      
|38. |  | PPD Development (Thailand) Co., LTD.                      |  | Thailand                                    
|39. |  | PPD Japan K.K.                                            |  | Japan                                       
|40. |  | PPD Global, LTD                                           |  | United Kingdom                              
|41. |  | Clinical Technology Centre International LTD              |  | United Kingdom                              
|42. |  | Cambridge Applied Nutrition Toxicology & Biosciences LTD  |  | United Kingdom                              



---

|    |  |                                                      |  |                
|--- |  | ---------------------------------------------------- |  | ---------------
|43. |  | Clinical Science Research International, LTD         |  | United Kingdom 
|44. |  | Leicester Clinical Research Centre, LTD              |  | United Kingdom 
|45. |  | Chelmsford Clinical Trials Unit, LTD                 |  | United Kingdom 
|46. |  | Gabbay, LTD                                          |  | United Kingdom 
|47. |  | Data Analysis & Research (DAR) LTD                   |  | United Kingdom 
|48. |  | PPD Global Central Labs BVBA                         |  | Belgium        
|49. |  | PPD Development (S) PTE LTD                          |  | Singapore      
|50. |  | PPD Development (HK) Limited                         |  | Hong Kong      
|51. |  | Propharma CRO PTY LTD                                |  | Australia      
|52. |  | PPD (Netherlands) BV                                 |  | Netherlands    
|53. |  | PPD Pharmaceutical Development India Private Limited |  | India          
|54. |  | PPD Biomarker Discovery Sciences, LLC                |  | North Carolina 
|55. |  | River Ventures LLC                                   |  | North Carolina 
|56. |  | PPD Slovak Republic s.r.o.                           |  | Slovak Republic

Subsidiaries 1, 2, 3, 4, 5, 6 are wholly-owned subsidiaries of Pharmaceutical
Product Development, Inc.

Subsidiaries 7, 8, 10, 11, 13 and 54 are wholly-owned subsidiaries of Subsidiary 1.

Subsidiary 14 is a wholly-owned subsidiary of Subsidiary 6.

Subsidiary 15 is owned 99.9% by Subsidiary 11 and 0.1% by Subsidiary 10.

Subsidiaries 16, 17, 18, 19, 20, and 55 are wholly-owned subsidiaries of Subsidiary 15.

Subsidiaries 9, 12, 22, 23, 27, 28, 29, 30, 36, 38 and 39 are wholly-owned subsidiaries of Subsidiary 20.

Subsidiary 21 is owned 99.9% by Subsidiary 20 and 0.1% by Subsidiary 1.

Subsidiary 24 is owned 99.99% by Subsidiary 20 and 0.01% by Pharmaceutical Product Development, Inc.

Subsidiary 25 is owned 95% by Subsidiary 20 and 5% by Subsidiary 1.

Subsidiary 26 is owned 99% by Subsidiary 20 and 1% by Subsidiary 1.

Subsidiaries 31, 32, and 33 are wholly-owned subsidiaries of Subsidiary 30.

Subsidiary 34 is owned 72% by Subsidiary 30 and 28% by Subsidiary 31.

Subsidiary 35 is owned 96.7% by Subsidiary 30 and 3.3% by Subsidiary 20.

Subsidiary 37 is owned 99.99% by Subsidiary 20 and 0.01% by Subsidiary 15.

Subsidiaries 40, 44, 45, 46, 47, 49, and 52 are wholly-owned subsidiaries of Subsidiary 12.

Subsidiaries 41, 42 and 43 are wholly-owned subsidiaries of Subsidiary 40.

Subsidiary 48 is 99.9% owned by Subsidiary 12 and 0.1% by Subsidiary 40.

Subsidiary 50 is 50% owned by Subsidiary 49 and 50% by Subsidiary 1.

Subsidiary 51 is a wholly-owned subsidiary of Subsidiary 49.

Subsidiary 53 is owned 99.99% by Subsidiary 12 and 0.01% by Subsidiary 40.

Subsidiary 56 is owned 85% by Subsidiary 12 and 15% by Subsidiary 40.