Exhibit 31.1

CERTIFICATION
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY  ACT OF 2002

I, Raymond P.
Warrell, Jr., M.D., certify that:

|1. |  | I
have  reviewed this  Quarterly  Report on Form 10-Q  of Genta Incorporated (the registrant);
|-- |  | ------------------------------------------------------------------------------------------------

|2. |  | Based
on my  knowledge,  this report does not contain  any untrue  statement  of a material
fact or omit to  state  a  material  fact  necessary  to  make  the  statements  made,
in  light  of  the  circumstances  under  which  such  statements  were  made,  not
misleading  with  respect  to the  period  covered by  this report;
|-- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|3. |  | Based
on my  knowledge,  the  financial  statements,  and  other  financial  information
included  in this  report,  fairly present in all material  respects the  financial
condition,  results of operations and cash  flows of the  registrant  as of, and for, the
periods  presented in this report;
|-- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|4. |  | The
registrants  other certifying  officer and I are  responsible  for  establishing
and  maintaining  disclosure  controls  and  procedures  as  defined in  Exchange  Act
Rules  13a-15(e)  and  15d-15(e)  and  internal  control  over  financial  reporting  as
defined  in  Exchange  Act  Rules  13a-15(f)  and  15d-15(f) for the registrant and we
have:
|-- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | a) |  | Designed
such  disclosure  controls and  procedures,  or  caused  such  disclosure  controls  and
procedures  to  be  designed  under  our  supervision,  to  ensure  that  material
information  relating  to  the  registrant,  including  its  consolidated  subsidiaries,
is made known to us by others  within  those  entities,  particularly  during  the
period  in which this report is being prepared;
| | -- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | b) |  | Designed
such  internal  control  over  financial  reporting,  or caused such internal  control
over  financial  reporting  to  be  designed  under  our  supervision,  to  provide
reasonable  assurance  regarding  the  reliability  of financial  reporting and the
preparation  of  financial  statements  for  external  purposes  in  accordance  with
generally accepted accounting principles;
| | -- |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | c) |  | Evaluated
the  effectiveness  of  the  registrants  disclosure  controls  and  procedures
and  presented  in this  report  our  conclusions  about the  effectiveness  of the
disclosure  controls  and  procedures,  as of the end of  the period  covered by this
report  based on  such evaluation; and
| | -- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | d) |  | Disclosed
in  this  report  any  change  in  the  registrants  internal  control  over
financial  reporting  that  occurred  during  the  registrants  most  recent
fiscal  quarter  that has  materially  affected,  or  is reasonably  likely to materially
affect,  the  registrants  internal  control  over  financial reporting; and
| | -- |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|5. |  | The
registrants  other  certifying  officer  and  I  have disclosed,  based on our most
recent  evaluation  of internal  control  over  financial  reporting,  to  the  registrants
auditors  and the audit  committee  of the  registrants  board of directors  (or
persons  performing the equivalent functions):
|-- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | a) |  | All
significant  deficiencies  and  material  weaknesses  in the  design or  operation  of
internal  control over  financial  reporting  which are  reasonably  likely  to
adversely  affect the  registrants  ability to record,  process,  summarize  and
report  financial  information; and
| | -- |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| | b) |  | Any
fraud,  whether or not  material,  that  involves  management  or  other  employees  who
have a  significant  role  in  the  registrants  internal control over financial
reporting.
| | -- |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|Date:                             | May 9, 2006                                | 
|--------------------------------- | ------------------------------------------ | 
|                                  |                                            | 
|/s/ RAYMOND P. WARRELL, JR., M.D. |                                           
|                                  |                                           
|Name:                             | Raymond P. Warrell, Jr., M.D.              | 
|Title:                            | Chairman and
      Chief Executive Officer | 

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