|Exhibit 3.2.1




CERTIFICATE
OF AMENDMENT OFRESTATED CERTIFICATE OF INCORPORATIONOFIMPATH INC.

Pursuant to Section 242
ofthe General Corporation Law ofthe State of Delaware


IMPATH
Inc., a corporation organized and existing under and by virtue of the
General Corporation Law of the State of Delaware (the Corporation),
DOES HEREBY CERTIFY as follows:


FIRST: The
Restated Certificate of Incorporation of the Corporation is hereby
amended by deleting in its entirety the first paragraph of ARTICLE
IV of the Restated Certificate of Incorporation in its present form and
substituting there for a new first paragraph of ARTICLE IV in the
following form:
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| | The
total number of shares of capital stock which the Corporation shall have authority to issue is
One Million (1,000,000) shares of preferred stock, $.01 par value per share (the Preferred
Stock), and Fifty Million (50,000,000) shares of common stock, $.005 par value per share (the Common Stock).
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|SECOND: The amendment to the Restated Certificate of Incorporation of the Corporation set forth
in this Certificate of Amendment has been duly adopted in accordance with the applicable
provisions of Section 242 of the
General Corporation Law of the State of Delaware, (a) the
Board of Directors of the Corporation having duly adopted
a resolution setting forth such amendment and declaring its
advisability and submitting it to the stockholders of
the Corporation for their approval in conformity with the By-Laws of the
Corporation and (b) the holders of a majority of the outstanding
stock of the Corporation entitled to vote there on having voted to
approve such amendment at a meeting of the stockholders.


THIRD: The
effective time of the amendment to the Restated Certificate of Incorporation of the
Corporation set forth in this Certificate of Amendment shall be as of the date filed by
the Secretary of State of the State of Delaware.
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