|FIRST AMENDATORY
AGREEMENTTO CREDIT AGREEMENT



THIS
FIRST AMENDATORY AGREEMENT TO CREDIT AGREEMENTmade as of the
30th of September, 2001 by and among IMPATH INC., a Delaware
corporation with its chief executive office at 521 West 57th Street,
New York, New York 10019, and IMPATH PREDICTIVE ONCOLOGY, INC., a Delaware
corporation with its chief executive office at 521 West 57th Street,
New York, New York 10019 and IMPATH-BIS INC., a Delaware corporation with its
chief executive office at 521 West 57th Street, New York, New York
10019, and MEDICAL REGISTRY SERVICES, INC., a Delaware corporation with its
chief executive office at 521 West 57th Street, New York, New York
10019, and IMPATH-BCP., a Delaware corporation with its chief executive office
at 521 West 57th Street, New York, New York 10019, and IMPATH-PCRL
INC., a Delaware corporation with its chief executive office at 521 West
57th Street, New York, New York 10019, and IMPATH-HDC, INC., a
Delaware corporation with its chief executive office at 521 West 57th
Street, New York, New York 10019, and IMPATH INFORMATION SERVICES, INC., a
Delaware corporation with its chief executive office at 521 West 57th
Street, New York, New York 10019 (each the foregoing, a Borrower and
collectively the Borrowers), and each of the financial institutions
identified as Lenders on Schedule 1 annexed to the Credit Agreement and made a
part hererof (together with each of their successors and assigns, referred to
individually as a Lender and, collectively, as the
Lenders), and FLEET NATIONAL BANK, a national banking association
with an office at 1185 Avenue of the Americas, New York, New York 10036 (the
Bank), acting in the manner and to the extent described in Article
IX of the Credit Agreement (in such capacity, the Agent


W I T N E S S E T H:


WHEREAS,
the Borrowers and the Agent and the Lenders entered into a certain Credit
Agreement dated June 4, 2000 (the Credit Agreement); and


WHEREAS,
the Borrowers and the Agent and Lenders desire to amend the Credit Agreement as
hereinafter set forth.


NOW,
THEREFORE, in consideration of the mutual covenants and conditions
hereinafter contained, the Borrowers and the Lenders hereby agree as follows:


1. All
capitalized terms not otherwise defined herein shall have the meaning ascribed to them in
the Credit Agreement.


2. The
definition of EBITDA is hereby amended to read in its entirety as follows:


EBITDA
means income from continuing operations before interest, taxes, depreciation and
amortization determined in accordance with GAAP. For the purpose only of
testing compliance with any financial covenant hereunder, EBITDA
means income from continuing operations before interest, taxes, depreciation and
amortization determined in accordance with GAAP, plus (a) up to Three Million
Two Hundred Thousand Dollars ($3,200,000) directly related to the settlement of
certain litigation in the fourth quarter of 2000, and (b) up to Nine Million
Dollars ($9,000,000) expensed in the third quarter of 2001 in connection with
the Companys settlement with the United States Department of Justice.
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|3. All
other sections of the Credit Agreement remain unchanged and in full force and effect.



4. Borrowers hereby
reaffirm all covenants, representations, warranties, and agreements contained in
the Credit Agreement and certify that except as otherwise specifically indicated
herein, all representations made in the Credit Agreement remain correct and
accurate.


Except
as herein amended, the Credit Agreement shall remain unmodified and in full
force and effect and binding upon the parties thereto.



[Signature page follows]


- 2 -
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

|IN
WITNESS WHEREOF, the parties have caused this Agreement to be duly executed and
delivered by the proper and duly authorized officers as of the date and year
first above written.
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

| |  | AGENT: | 
| |  | ------ | 

| |  | Fleet National BankBy: /s/  Christian J. Covello
      Name: Christian J. Covello
      Title:   Vice President
| |  | -----------------------------------------------------------------------------------------------------------------------------

| |  | BORROWERS: | 
| |  | ---------- | 

| |  | IMPATH Inc.By: /s/  Richard C. Rosenzweig
      Name: Richard C. Rosenzweig
      Title:   Vice President and General Counsel
| |  | -------------------------------------------------------------------------------------------------------------------------------------------

| |  | IMPATH Predictive Oncology, Inc.By: /s/  Richard C. Rosenzweig
      Name: Richard C. Rosenzweig
      Title:   Vice President and General Counsel
| |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------

| |  | IMPATH-BIS, Inc.By: /s/  Richard C. Rosenzweig
      Name: Richard C. Rosenzweig
      Title:   Vice President and General Counsel
| |  | ------------------------------------------------------------------------------------------------------------------------------------------------

| |  | Medical Registry Services, Inc.By: /s/  Richard C. Rosenzweig
      Name: Richard C. Rosenzweig
      Title:   Vice President and General Counsel
| |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------

| |  | IMPATH-BCP, Inc.By: /s/  Richard C. Rosenzweig
      Name: Richard C. Rosenzweig
      Title:   Vice President and General Counsel
| |  | ------------------------------------------------------------------------------------------------------------------------------------------------

| |  | IMPATH-PCRL, Inc.By: /s/  Richard C. Rosenzweig
      Name: Richard C. Rosenzweig
      Title:   Vice President and General Counsel
| |  | -------------------------------------------------------------------------------------------------------------------------------------------------

|
|

| |  | IMPATH-HDC, Inc.By: /s/  Richard C. Rosenzweig
      Name: Richard C. Rosenzweig
      Title:   Vice President and General Counsel
| |  | ------------------------------------------------------------------------------------------------------------------------------------------------

| |  | IMPATH Information Services, Inc.By: /s/  Richard C. Rosenzweig
      Name: Richard C. Rosenzweig
      Title:   Vice President and General Counsel
| |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------

| |  | LENDERS: | 
| |  | -------- | 

| |  | Fleet National BankBy: /s/  Christian J. Covello
      Name: Christian J. Covello
      Title:   Vice President
| |  | -----------------------------------------------------------------------------------------------------------------------------

| |  | The Bank of New YorkBy: /s/ Gina Beyer
      Name: Gina Beyer
      Title:   Vice President
| |  | ---------------------------------------------------------------------------------------------------------

| |  | Key  Corporate Capital Inc.By: /s/ James R. Lynch, Jr.
      Name: James R. Lynch, Jr.
      Title:   Vice President
| |  | ----------------------------------------------------------------------------------------------------------------------------------