Exhibit3.1

PAGE1

Delaware

TheFirst State

I, HARRIET SMITH WINDSOR, SECRETARYOF STATE OF THE STATE OF DELAWARE, DO HEREBY CERTIFY THE ATTACHED IS ATRUE AND CORRECT COPY OF THE CERTIFICATE OF AMENDMENT OF‘‘GENTA INCORPORATED’’, FILED IN THIS OFFICE ONTHE NINETEENTH DAY OF JUNE, A.D. 2006, AT 4:46 O'CLOCKP.M.

A FILED COPY OF THIS CERTIFICATE HAS BEEN FORWARDEDTO THE NEW CASTLE COUNTY RECORDER OFDEEDS.

|                                              |  |  |        |  |  |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |
|----------------------------------------------|--|--|--------|--|--|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 21510908100    060589240 |  |  | [SEAL] |  |  | /s/Harriet SmithWindsor                             HarrietSmith Windsor, Secretary of State    AUTHENTICATION:4838464                                            DATE:06-19-06 |
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|        |  |  |                                   |
|--------|--|--|-----------------------------------|
|   |  |  | Stateof Delaware                  |
|   |  |  | Secretaryof State                 |
|   |  |  | Division ofCorporations           |
|   |  |  | Delivered04:48 PM 06/19/2006      |
|   |  |  | FILED 04:46 PM06/19/2006          |
|   |  |  | SRV060589240 – 2151090 FILE |
|        |

CERTIFICATEOF AMENDMENT OF RESTATED CERTIFICATE OF INCORPORATIONOF GENTA INCORPORATED

Pursuant to Section 242 of theGeneral Corporation Law of the State of Delaware

* ** *

Genta Incorporated, a Delaware corporation (hereinaftercalled the ‘‘Corporation’’), does herebycertify as follows:

FIRST: The Corporation's Certificateof Incorporation is hereby amended by deleting the first sentence ofArticle IV(A) and substituting in lieu thereof the following:

‘‘(A) Classes of Capital Stock.The total number of shares of capital stock which the Corporation shallhave authority to issue is two hundred and fifty-five million(255,000,000), of which two hundred and fifty million (250,000,000)shares shall be common stock, par value $.001 per share (the‘‘Common Stock’’), and five million (5,000,000)shares shall be preferred stock, par value $.001 per share (the‘‘Preferred Stock’’).

SECOND: Theforegoing amendment was duly adopted in accordance with Section 242 ofthe General Corporation Law of the State of Delaware.

IN WITNESSWHEREOF, Genta Incorporated has caused this Certificate of Amendment tobe signed by Raymond P. Warrell, Jr., M.D., its Chief ExecutiveOfficer, this 16th day of June, 2006.

|  | GENTA INCORPORATED |
|--|--------------------|

|  | By: /s/Raymond P. Warrell, Jr., M.D. |
|--|--------------------------------------|

|  | Title: ChiefExecutive Officer |
|--|-------------------------------|

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