Exhibit 31.1

CERTIFICATION
PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Raymond P.
Warrell, Jr., M.D., certify that:

|1. |  | I
have  reviewed  this  Quarterly  Report  on  Form  10-Q  of  Genta  Incorporated (the
registrant);
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|2. |  | Based
on  my  knowledge,  this  report  does  not  contain  any  untrue  statement of a
material fact or omit to state a material fact  necessary  to make the statements made,
in light of the  circumstances  under which  such  statements  were made, not  misleading
with respect to the period  covered by this report;
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|3. |  | Based
on my knowledge,  the financial  statements,  and other  financial  information  included
in this  report,  fairly  present in all  material  respects the financial  condition,
results of operations and cash flows  of the registrant as of, and for, the periods
presented in this report;
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|4. |  | The
registrants  other  certifying  officer and I are  responsible for  establishing
and  maintaining  disclosure  controls and  procedures (as  defined  in  Exchange  Act
Rules  13a-15(e)  and  15d-15(e))  for  the  registrant and we have:
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| | a) |  | Designed
such  disclosure  controls  and  procedures,  or  caused  such  disclosure  controls and
procedures to be designed under our  supervision,  to ensure that material  information
relating  to the registrant,  including its consolidated subsidiaries,  is  made  known
to  us by  others  within  those  entities,  particularly  during  the  period  in which
this  report is  being prepared;
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| | b) |  | Designed
such internal control over financial reporting,  or caused such  internal  control  over
financial  reporting to be designed  under  our  supervision,  to  provide  reasonable
assurance  regarding  the  reliability  of financial  reporting and the  preparation of
financial  statements  for external  purposes  in accordance with generally accepted
accounting principles;
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| | c) |  | Evaluated
the effectiveness of the registrants  disclosure controls and  procedures  and
presented  in this  report our  conclusions  about  the  effectiveness  of the
disclosure  controls  and  procedures,  as of the  end of the  period  covered  by this
report based on such evaluation; and
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| | d) |  | Disclosed
in  this  report  any  change  in the  registrants  internal  control over
financial  reporting  that occurred  during the  registrants  most recent fiscal
quarter that has materially  affected,  or is reasonably likely to materially affect, the
registrants internal control over financial reporting; and
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|5. |  | The
registrants  other certifying  officer and I have disclosed,  based  on our  most
recent  evaluation  of  internal  control  over  financial  reporting,  to the registrants
auditors and the audit committee of the  registrants  board of directors (or
persons  performing  the equivalent  functions):
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| | a) |  | All
significant  deficiencies  and material  weaknesses in the design or  operation  of
internal  control  over  financial  reporting  which  are  reasonably  likely  to
adversely  affect  the  registrants  ability  to  record,  process,  summarize  and
report financial information; and
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| | b) |  | Any
fraud,  whether or not material,  that involves  management or other  employees  who have
a significant  role in the  registrants  internal control over financial reporting.
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Date: August
9, 2005

|/s/ RAYMOND P. WARRELL, JR., M.D.
|---------------------------------
|Name:                            
|Title:                           

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