Exhibit 21

Pharmaceutical Product Development, Inc., and Subsidiaries

Subsidiaries

The subsidiaries of Pharmaceutical Product Development, Inc., as of February 15, 2007, are as follows:



|    |  |                                                           |  |                                              
|--- |  | --------------------------------------------------------- |  | ---------------------------------------------
|    |  | Name of Subsidiary                                        |  | Jurisdiction of Incorporation Or Organized
in
|1.  |  | Applied Bioscience International, LLC                     |  | Delaware                                     
|2.  |  | CSS Informatics, Inc.                                     |  | California                                   
|3.  |  | PPD Global Central Labs, LLC                              |  | Kentucky                                     
|4.  |  | Piedmont Research Center, LLC                             |  | North Carolina                               
|5.  |  | PPD Aeronautics, LLC                                      |  | North Carolina                               
|6.  |  | PPD Virtual, Inc.                                         |  | North Carolina                               
|7.  |  | APBI Finance Corporation                                  |  | Delaware                                     
|8.  |  | APBI Holdings, LLC                                        |  | North Carolina                               
|9.  |  | Development Partners, LLC                                 |  | Delaware                                     
|10. |  | PPD GP, LLC                                               |  | Delaware                                     
|11. |  | PPD Holdings, LLC                                         |  | Delaware                                     
|12. |  | PPD UK Holdings Ltd                                       |  | United Kingdom                               
|13. |  | Genupro, Inc.                                             |  | North Carolina                               
|14. |  | PPD Development, LP                                       |  | Texas                                        
|15. |  | ATP, LLC                                                  |  | North Carolina                               
|16. |  | PPD Online Marketing and Education, Inc.                  |  | Delaware                                     
|17. |  | PPD Medical Device, Inc.                                  |  | Delaware                                     
|18. |  | Pharmaco Investments, Inc.                                |  | Delaware                                     
|19. |  | PPD International Holdings, Inc.                          |  | Delaware                                     
|20. |  | PPD France SNC                                            |  | France                                       
|21. |  | PPD Scandinavia AB                                        |  | Sweden                                       
|22. |  | Pharmaceutical Product Development Spain SL               |  | Spain                                        
|23. |  | PPD do Brasil-Suporte a Pesquisa Clinica Ltda.            |  | Brazil                                       
|24. |  | PPD Argentina, S.A.                                       |  | Argentina                                    
|25. |  | PPD International Holdings, Inc. Y Compania Limitada      |  | Chile                                        
|26. |  | Pharmaceutical Product Development South Africa (Pty) Ltd |  | South Africa                                 
|27. |  | PPD Canada, Ltd.                                          |  | Canada                                       
|28. |  | PPD Australia Pty Ltd                                     |  | Australia                                    
|29. |  | PPD International Holdings GmbH                           |  | Germany                                      
|30. |  | PPD Germany GmbH                                          |  | Germany                                      
|31. |  | PPD Poland Sp.Zo.o                                        |  | Poland                                       
|32. |  | PPD Czech Republic, s.r.o.                                |  | Czech Republic                               
|33. |  | PPD Germany GmbH & Co KG                                  |  | Germany                                      
|34. |  | PPD Hungary Research & Development Limited                |  | Hungary                                      
|35. |  | PPD Italy S.r.l.                                          |  | Italy                                        
|36. |  | PPD Mexico, S.A. de C.V.                                  |  | Mexico                                       
|37. |  | PPD Development (Thailand) Co., Ltd                       |  | Thailand                                     
|38. |  | PPD Japan K.K.                                            |  | Japan                                        
|39. |  | PPD Global, Ltd                                           |  | United Kingdom                               
|40. |  | Clinical Technology Centre International Ltd              |  | United Kingdom                               
|41. |  | Cambridge Applied Nutrition Toxicology & Biosciences Ltd  |  | United Kingdom                               



---

|    |  |                                                      |  |                
|--- |  | ---------------------------------------------------- |  | ---------------
|42. |  | Clinical Science Research International, Ltd         |  | United Kingdom 
|43. |  | Leicester Clinical Research Centre, Ltd              |  | United Kingdom 
|44. |  | Chelmsford Clinical Trials Unit, Ltd                 |  | United Kingdom 
|45. |  | Gabbay Ltd                                           |  | United Kingdom 
|46. |  | Data Analysis & Research (DAR) Ltd                   |  | United Kingdom 
|47. |  | PPD Global Central Labs BVBA                         |  | Belgium        
|48. |  | PPD Development (S) Pte Limited                      |  | Singapore      
|49. |  | PPD Development (HK) Limited                         |  | Hong Kong      
|50. |  | Propharma CRO PTY LTD                                |  | Australia      
|51. |  | PPD (Netherlands) BV                                 |  | Netherlands    
|52. |  | PPD Pharmaceutical Development India Private Limited |  | India          
|53. |  | PPD Biomarker Discovery Sciences, LLC                |  | North Carolina 
|54. |  | River Ventures LLC                                   |  | North Carolina 
|55. |  | PPD Slovak Republic s.r.o.                           |  | Slovak Republic
|56. |  | PPD Peru S.A.C                                       |  | Peru           

Subsidiaries 1, 2, 3, 4, and 6 are wholly-owned subsidiaries of Pharmaceutical Product Development, Inc.

Subsidiaries 10 and 11 are wholly-owned subsidiaries of Subsidiary 1.

Subsidiary 13 is a wholly-owned subsidiary of Subsidiary 6.

Subsidiary 14 is owned 99.9% by Subsidiary 11 and 0.1% by Subsidiary 10.

Subsidiaries 5, 7, 8, 15, 16, 17, 18, 19, 53 and 54 are wholly-owned subsidiaries of Subsidiary 14.

Subsidiaries 9, 12, 21, 22, 26, 27, 28, 29, 35, 37, and 38 are wholly-owned subsidiaries of Subsidiary 19.

Subsidiary 20 is
owned 99.9% by Subsidiary 19 and 0.1% by Subsidiary 1.

Subsidiary 23 is owned 99.99% by Subsidiary 19 and 0.01% by Pharmaceutical Product Development, Inc.

Subsidiary 24 is owned 95% by Subsidiary 19 and 5% by Subsidiary 1.

Subsidiary 25 is owned 99% by Subsidiary 19 and 1% by Subsidiary 1.

Subsidiaries 30, 31, and 32 are wholly-owned subsidiaries of Subsidiary 29.

Subsidiary 33 is owned 72% by Subsidiary 29 and 28% by Subsidiary 30.

Subsidiary 34 is owned 96.7% by Subsidiary 29 and 3.3% by Subsidiary 19.

Subsidiary 36 is owned 99.99% by Subsidiary 19 and 0.01% by Subsidiary
14.

Subsidiaries 39, 43, 44, 45, 46, 48, and 51 are wholly-owned subsidiaries of Subsidiary 12.

Subsidiaries 40, 41 and 42 are wholly-owned subsidiaries of Subsidiary 39.

Subsidiary 47 is 99.9% owned by Subsidiary 12 and 0.1% by Subsidiary 39.

Subsidiary 49 is 50% owned by Subsidiary 48 and 50% by Subsidiary 1.

Subsidiary 50 is a wholly-owned subsidiary of Subsidiary 48.

Subsidiary 52 is owned 99.99% by Subsidiary 12 and 0.01% by Subsidiary 39.



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Subsidiary 55 is owned 85% by Subsidiary 12 and 15% by Subsidiary 39.

Subsidiary 56 is owned 99% by Subsidiary 19 and 1% by Subsidiary 1.