Exhibit 31.1

CERTIFICATION PURSUANT TO SECTION 302 OF THE SARBANES-OXLEY ACT OF 2002

I, Raymond P.
Warrell, Jr., M.D., certify that:

|1. |  | I
have  reviewed  this  Quarterly  Report  on  Form  10-Q  of  Genta  Incorporated (the
registrant);
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|2. |  | Based on my  knowledge,  this report does not contain  any untrue  statement  of a material  fact or omit to
                  state a material fact necessary to make the statements made, in light of the circumstances  under which such
                  statements were made, not misleading with respect to the period covered by this report;
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|3. |  | Based
on my knowledge,  the financial  statements,  and other  financial  information  included
in this  report,  fairly  present in all  material  respects the financial  condition,
results of operations and cash flows  of the registrant as of, and for, the periods
presented in this report;
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|4. |  | The registrants other certifying officer and I are responsible for establishing and maintaining  disclosure
                  controls and procedures as defined in Exchange Act Rules  13a-15(e) and 15d-15(e) and internal  control over
                  financial reporting as defined in Exchange Act Rules 13a-15(f) and 15d-15(f) for the registrant and we have:
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| | a) |  | Designed such disclosure  controls and procedures,  or caused such disclosure  controls and procedures to be
                                    designed  under our  supervision,  to ensure  that  material  information  relating to the
                                    registrant,  including its consolidated subsidiaries, is made known to us by others within
                                    those entities, particularly during the period in which this report is being prepared;
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| | b) |  | Designed such internal  control over  financial  reporting,  or caused such internal  control over financial
                                    reporting to be designed under our supervision,  to provide reasonable assurance regarding
                                    the  reliability of financial  reporting and the  preparation of financial  statements for
                                    external purposes in accordance with generally accepted accounting principles;
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| | c) |  | Evaluated the  effectiveness  of the registrants  disclosure  controls and procedures and presented in this
                                    report our conclusions about the effectiveness of the disclosure  controls and procedures,
                                    as of the end of the period covered by this report based on such evaluation; and
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| | d) |  | Disclosed in this report any change in the  registrants  internal  control over  financial  reporting  that
                                    occurred during the registrants most recent fiscal quarter that has materially  affected,
                                    or is reasonably  likely to materially  affect,  the  registrants  internal  control over
                                    financial reporting; and
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|5. |  | The  registrants  other  certifying  officer and I have disclosed,  based on our most recent  evaluation of
                  internal  control over financial  reporting,  to the  registrants  auditors and the audit  committee of the
                  registrants board of directors (or persons performing the equivalent functions):
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| | a) |  | All significant  deficiencies  and material  weaknesses in the design or operation of internal  control over
                                    financial  reporting  which are  reasonably  likely to adversely  affect the  registrants
                                    ability to record, process, summarize and report financial information; and
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| | b) |  | Any fraud, whether or not material,  that involves management or other employees who have a significant role
                                    in the registrants internal control over financial reporting.
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Date: November 7, 2005

|/s/ RAYMOND P. WARRELL, JR., M.D.
|---------------------------------
|Name:                            
|Title:                           

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