Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND 

 POLLUTION PREVENTION

MEMORANDUM 

DATE: 4/25/13 

SUBJECT: Dinotefuran: Acute and Chronic Aggregate Dietary (Food and Drinking 

Water) Exposure and Risk Assessments for the Section 18 for Use on 

Pome and Stone Fruits in MI. 

PC Code: 044312 DP Barcode: D410585 

Decision No.: 476056 Registration Nos.: 59639-135, 10163-317 

Petition No.: NA Regulatory Action: Section 18 

Risk Assessment Type: Dietary Case No.: NA 

TXR No.: NA CAS No.: 165252-70-0

MRID No.: NA 40 CFR: §180.603 

REVIEWER: Nancy Dodd, Chemist 

 Risk Assessment Branch III (RAB3) 

 Health Effects Division (HED; 7509P) 

THROUGH: Douglas Dotson, Chemist 

 Julie L. Van Alstine, MPH, Environmental Health Scientist 

Dietary Exposure Science Advisory Council (DESAC)/HED (7509P) 

TO: Tawanda Maignan/Andrea Conrath, RM #9 

 Risk Integration, Minor Use, and Emergency Response Branch 

 Registration Division (7505P) 

Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk 

assessments were conducted using the Dietary Exposure Evaluation Model software with 

the Food Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 

2003-2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) 

National Health and Nutrition Examination Survey, What We Eat in America 

(NHANES/WWEIA). The analyses were conducted in support of a human-health risk 

assessment for the proposed Section 18 emergency exemption requested by MI for use of 

dinotefuran on pome and stone fruits. This memorandum was reviewed by two peer 

reviewers of the DESAC, per DESAC SOP 2012.1. 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

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Acute Dietary Exposure Assessment

An unrefined acute screening-level dietary assessment was conducted assuming that all 

of the crops associated with the requested and currently registered uses of dinotefuran are 

100% treated and that all treated crops contain tolerance-level residues, corrected for 

additional residues which are of concern for the risk assessment only. Correction factors 

were used to add residues of the metabolites PHP (6-hydroxy-5-(2-hydroxyethyl)-1-

methyl-1,3-diazinane-2-ylidene-N-nitroamine) in plants, UF (1-methyl-3-(tetrahydro-3-

furylmethyl)-urea) and FNG in ruminants, and FNG (2-nitro-1-(tetrahydro-3-

furylmethyl)guanidine) in poultry (refer to the adjustment factor #2 column of the residue 

input file). In addition, default processing factors were assumed for both registered and 

requested crop uses unless separate tolerances were established or empirical processing 

data were available. Potential residues in drinking water were included in the analyses 

based on surface water results from the provisionally modified Tier 1 Rice Model v.1.0 as 

these values were higher than the groundwater estimates from the Screening 

Concentration in Ground Water (SCI-GROW) model (D397490, James Wolf, 7-AUG2012). The results obtained from the present dietary analyses may be considered highly 

conservative. At the 95th percentile of exposure, no population subgroups exceed HED’s 

level of concern. The U.S. population occupied 3.7% of the acute population-adjusted 

dose (aPAD), while the most highly exposed population subgroup, children 1-2 years old, 

occupied 12% of the aPAD. 

Chronic Dietary Exposure Assessment

An unrefined chronic screening-level dietary assessment was conducted assuming that all 

of the crops associated with the requested and currently registered uses of dinotefuran are 

100% treated and that all treated crops contain tolerance-level residues, corrected for 

additional residues which are of concern for the risk assessment only. Correction factors 

were used to add residues of the metabolites PHP in plants, UF and FNG in ruminants, 

and FNG in poultry (refer to the adjustment factor #2 column of the residue input file). 

In addition, default processing factors were assumed for both registered and requested 

crop uses unless separate tolerances were established or empirical processing data were 

available. Potential residues in drinking water were included in the analyses based on 

surface water results from the modified Tier 1 Rice Model v.1.0 as these values were 

higher than the groundwater estimates from the SCI-GROW model (D397490, James 

Wolf, 7-AUG-2012). No population subgroups exceed HED’s level of concern. The 

U.S. population occupied 1.7% of the chronic population-adjusted dose (cPAD), while 

the most highly exposed population subgroup, children 1-2 years old, occupied 5.7% of 

the cPAD. 

Cancer Dietary Exposure Assessment

A determination of cancer risk was not performed with DEEM-FCID as part of the 

present assessment, since this chemical was classified as “not likely to be carcinogenic to 

humans” based on negative genotoxicity and carcinogenicity in long term cancer studies 

in rats and mice. 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

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I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population-adjusted dose (PAD). 

The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by 

the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary 

risk exceeds 100% of the PAD. References that discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: “Available 

Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, 

web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see 

SOP 99.6 (20-AUG-1999). 

The most recent dietary risk assessment for dinotefuran was conducted by Cassi Walls 

(8/20/12, D398050). 

II. Residue Information

Dinotefuran ((RS)-1-methyl-2-nitro-3-(tetrahydro-3-furylmethyl)guanidine) is a Group 

4A insecticide for which permanent tolerances have been established under 40 CFR 

§180.603. Tolerances have been established on various plant commodities at levels 

ranging from 0.05 ppm to 50 ppm under 40 CFR §180.603(a). For plants, compliance 

with the tolerance levels is to be determined by measuring only the sum of dinotefuran 

and its metabolites DN [1-methyl-3-(tetrahydro-3-furylmethyl)guanidine] and UF [1-

methyl-3-(tetrahydro-3-furylmethyl)urea)], calculated as the stoichiometric equivalent of 

dinotefuran. Tolerances have also been established under 40 CFR §180.603(b) for 

livestock commodities at levels of 0.01 ppm or 0.05 ppm. For livestock commodities, 

compliance with the tolerance levels is to be determined by measuring only dinotefuran. 

A use in food/feed handling establishments (FHE) with associated tolerances of 0.01 ppm 

is pending. 

The nature of the residue in plants and livestock commodities is understood (MARC 

report, TXR #52304, DP293759, L. Cheng, 1/20/2004). In plants, parent dinotefuran and 

the metabolites DN and UF are the residues of concern for tolerance monitoring, and 

dinotefuran, DN, UF, and PHP are the residues of concern for risk assessment. In 

livestock, dinotefuran is the residue of concern for tolerance monitoring; the residues of 

concern for risk assessment are dinotefuran and metabolites UF and FNG in ruminants, 

and dinotefuran and the metabolite FNG in poultry. 

For both the acute and chronic dietary analyses, the existing, pending, and recommended 

tolerances were used for each food commodity residue level. Default processing factors 

were also used except for dry potatoes, tomato paste, and grape raisins for which 

tolerances are established, and for grape juice and tomato puree for which processing 

studies are available which show that the tolerance for the raw agricultural commodity is 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

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adequate to cover the processed commodity. For these commodities, the processing 

factor was set to 1.0. The acute and chronic assessments also assume that 100% of the 

crops are treated. Tables 1 through 4 summarize the dinotefuran residue levels used in 

the acute and chronic dietary assessments. 

The pending FHE use was only included in the chronic assessment according to current 

HED policy. 

HED has concluded that no changes are needed to the existing tolerances for livestock 

commodities as a result of the proposed Section 18 uses on pome and stone fruits. 

The USDA Pesticide Data Program (PDP) monitored pesticide residues in catfish in 

2008, 2009, and 2010. Over this 3-year period, PDP analyzed 1479 samples of catfish 

for dinotefuran residues. None of the samples contained detectable residues. As a result, 

residues in fish were not included in the assessment. 

Correction factors were used to add residues of PHP in plants, UF and FNG in ruminants, 

and FNG in poultry to the dietary assessments (refer to the Tables 1 through 4 below and 

to the adjustment factor #2 column of the residue input files). The correction factors are 

based on the percentages of the total radioactive residues (% TRR) attributed to PHP in 

plants, UF and FNG in ruminants, and FNG in poultry. The % TRR is expressed in 

parent equivalents. The % TRR information was found in the dinotefuran metabolism 

studies (Metabolism Assessment Review Committee [MARC] meeting memo, TXR No. 

0052304, D293759, L. Cheng, 1/20/04). The memo contains % TRR data for apples, 

lettuce, potato, rape seed, rice, ruminants (goats), and poultry (hens). For this dietary 

assessment, the data are translated from apples to pome fruit; from lettuce to vegetable, 

leafy, except Brassica, group 4; from potato to subgroup 1C; and from rape seed to 

cottonseed; the highest % TRR available for plants was used for the other plant 

commodities. For each commodity, the %TRR representing the sum of the residues 

included only in the risk assessment was rounded to the closest 1% and then added to 

100% before entering in the adjustment factor #2 column of the residue input file as the 

correction factor. 

Table 1. Residues of PHP in Plants. 

Commodity PHP 

(% TRR*) 

Reported Rounded 

Cotton, undelinted seed 7.0 7 

Fruit, pome 13.5 14 

Potato, chips 6.9 7 

Potato, granules/flakes 6.9 7 

Rice, grain 7.0 7 

Vegetable, leafy, except Brassica, 

group 4 

5.1 5 

Vegetable, tuberous and corm, 

subgroup 1C 

6.9 7 

All other plant commodities 13.5 14 

* The % TRR is expressed in parent equivalents. 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

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Table 2. Residues of UF and FNG in Ruminants. 

Commodity UF 

(% TRR*) 

FNG 

(% TRR*) 

UF + FNG 

(% TRR*) 

Reported Reported Reported Rounded 

Fat of cattle, goat, 

hog, horse, and 

sheep 

7.4 3.1 10.5 10 

Meat of cattle, goat, 

hog, horse, and 

sheep 

14.6 6.5 21.1 21 

Meat byproducts of 

cattle, goat, hog, 

horse, and sheep** 

7.4 20.1 27.5 28 

Milk 8.7 6.9 15.6 16 

* The % TRR is expressed in parent equivalents. 

**The highest % reported for fat, liver, and kidney is used for meat byproducts. 

Table 3. Residues of FNG in Poultry. 

Commodity FNG 

(% TRR*) 

Reported Calculated Rounded 

Egg 13.1% egg white 

8.0% egg yolk 

9.7% combined egg 

white and yolk*** 

10% combined egg 

white and yolk 

Poultry, meat byproducts** 6.5 --- 6 

* The % TRR is expressed in parent equivalents. 

**The highest % reported for fat and liver is used for meat byproducts. 

***The whole egg (100% with shell) is composed of 31.0% yolk, 58.0% egg white, and 11.0% shell. 

To express egg yolk and egg white as 100%, egg yolk would be 34.83% and egg white would be 65.17%. 

To calculate the % TRR in combined egg white and egg yolk: 13% TRR x 34.83/100 + 8.0% TRR x 

65.17/100 = 9.7% TRR in combined egg white and egg yolk. 

Table 4. Summary of Dinotefuran Tolerances and Correction Factors Used in Acute and Chronic 

Analyses. 

Commodity Tolerance Levels1

 (ppm) 

Correction Factors4

(%) 

Plant Commodities 

Berry, low growing, except 

strawberry, subgroup 13-07H 

0.2 114 

Brassica, head and stem, subgroup 

5A 

1.4 114 

Brassica, leafy greens, subgroup 5B 15.0 114 

Cotton, undelinted seed 0.4 107 

Fruit, pome2 2.0 114 

Fruit, small, vine climbing, except 

fuzzy kiwifruit, subgroup 13-07F 

0.9 114 

Fruit, stone2 2.0 114 

Grape, raisin 2.5 114 

Onion, bulb, subgroup 3-07A 0.15 114 

Onion, green, subgroup 3-07B 5.0 114 

Potato, chips 0.1 107 

Potato, granules/flakes 0.15 107 

Rice, grain 9.0 107 

Tea, dried 50 114 

Tomato, paste 1.0 114 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

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Table 4. Summary of Dinotefuran Tolerances and Correction Factors Used in Acute and Chronic 

Analyses. 

Commodity Tolerance Levels1

 (ppm) 

Correction Factors4

(%) 

Turnip, greens 15.0 114 

Vegetable, fruiting, group 8 0.7 114 

Vegetable, cucurbit, group 9 0.5 114 

Vegetable, leafy, except Brassica, 

group 4 

5.0 105 

Vegetable, tuberous and corm, 

subgroup 1C 

0.05 107 

Watercress 8.0 114 

All food/feed items (other than those 

already covered by a higher tolerance 

as a result of use on growing crops) 

in food/feed handling establishments 

where food products are held, 

processed or prepared3

0.01 114 

Livestock Commodities 

Egg 0.01 110 

Fat of cattle, goat, hog, horse, and 

sheep 

0.05 110 

Meat of cattle, goat, hog, horse, and 

sheep 

0.05 121 

Meat byproducts of cattle, goat, hog, 

horse, and sheep 

0.05 128 

Meat byproducts of poultry 0.01 106 

Milk 0.05 116 

1

 Residue levels are established tolerances unless otherwise indicated. 

2

 Recommended Section 18 tolerances. Since peach is a stone fruit, the lower established peach tolerance 

of 1.0 ppm is not used. 

3

 Pending tolerance 

4

 Correction factors were used to add residues of PHP in plants, UF and FNG in ruminants, and FNG in 

poultry to the dietary assessment. The correction factors were entered in the adjustment factor #2 column 

of the residue input files to correct for residues included in the risk assessment but not in the tolerance. 

III. Drinking Water Data 

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: 

“ Tier I Drinking Water Concentrations for Dinotefuran for Section 3 New Use on Rice” 

(D397490, J. Wolf & J. Hetrick, 8/7/12) and incorporated directly into this dietary 

assessment. Water residues were incorporated in the DEEM-FCID into the food 

categories “water, direct, all sources” and “water, indirect, all sources.” 

There are no drinking water monitoring data available on the concentrations of parent 

dinotefuran or any of its degradates. EFED provided a Tier 1 dinotefuran drinking water 

assessment with estimated drinking water concentrations (EDWCs) for dinotefuran and 

its metabolite/degradate DN. The modified Tier 1 Rice Model v.1.0 was used to 

determine EDWCs for surface water. Groundwater EDWCs were obtained with the Tier 

1 SCI-GROW model v.2.3 using the turf scenario. 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

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Table 5 summarizes the surface water EDWCs for dinotefuran and DN degradate. The 

peak concentration is 269 μg/L and the longer term concentration (≈average) would 

depend upon retention time (10 to 30 days). 

Table 5. Tier 1 Surface Water EDWCs (μg/L) for Drinking Water Risk Assessment for the Use of 

Dinotefuran on Rice. Based upon total toxic residues (Dinotefuran + DN). 

Peak 

Retention Time 

10 day 30 day 60 day 100 day 150 day 

269 257 253 248 240 198

The ground water EDWC, obtained using the Tier 1 SCI-GROW, is the same value for 

the turf use and the Section 18 rice use; 4.90 μg/L for both the acute and chronic 

exposures. Since the application rate for turf (1 application at 0.54 lb ai/A) is higher than 

for rice and since SCI-GROW is not site or crop dependent, the resulting water 

concentration is considered to be conservative.

Because the surface water estimates are higher than the groundwater estimates, the 

surface water values, expressed to two significant figures and converted to ppm, were 

directly incorporated in the DEEM-FCID into the food categories “water, direct, all 

sources” and “water, indirect, all sources.” The peak value of 269 μg/L (ppb) was used in 

the acute assessment and the 10 day retention time value of 257 μg/L was used in the 

chronic assessment. 

IV. DEEM-FCIDTM Program and Consumption Information

Dinotefuran acute and chronic dietary exposure assessments were conducted using the 

DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption data from 

USDA’s NHANES/WWEIA. The data are based on the reported consumption of more 

than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” 

(e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - 

cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly 

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire U.S. population and 

within population subgroups. However, for acute exposure assessment, consumption 

data are retained as individual consumption events. Based on analysis of the 2003-2008 

WWEIA consumption data, which took into account dietary patterns of survey 

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old. 

For a chronic dietary exposure assessment, an estimate of the residue level in each food 

or food-form (e.g., orange or orange juice) on the food commodity residue list is 

multiplied by the average daily consumption estimate for that food/food form to produce 

a residue intake estimate. The resulting residue intake estimate for each food/food form 

is summed with the residue intake estimates for all other food/food forms on the 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

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commodity residue list to arrive at the total average estimated exposure. Exposure is 

expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is 

performed for each population subgroup. 

For an acute exposure assessment, individual one-day food consumption data are used on 

an individual-by-individual basis. The reported consumption amounts of each food item 

can be multiplied by a residue point estimate and summed to obtain a total daily pesticide 

exposure for a deterministic exposure assessment, or “matched” in multiple random 

pairings with residue values and then summed in a probabilistic assessment. The 

resulting distribution of exposures is expressed as a percentage of the aPAD on both a 

user (i.e., only those who reported eating relevant commodities/food forms) and a percapita (i.e., those who reported eating the relevant commodities as well as those who did 

not) basis. In accordance with HED policy, per capita exposure and risk are reported for 

analyses performed at all levels of refinement. However, for deterministic assessments, 

any significant differences in user vs. per capita exposure and risk are specifically 

identified and noted in the risk assessment. 

V. Toxicological Information 

All information specific to the toxicity characteristics of dinotefuran is presented in the 

most recent risk assessment (D398048, Barry O’Keefe, 8/31/12). For the acute and 

chronic exposure scenarios, the standard 100 fold uncertainty factor was applied to 

account for inter-species extrapolation and intra-species variation. 

As previously noted, a cancer risk evaluation is not included in this assessment. To 

provide an overview of the toxicological profile, a summary of the doses and endpoints 

selected for the relevant dietary exposure scenarios is provided in Table 6. 

Table 6. Summary of Toxicological Doses and Endpoints for Dinotefuran for Use in Dietary 

Exposure Risk Assessments. 

Exposure/ 

Scenario 

Point of 

Departure 

Uncertainty/FQPA 

Safety Factors 

RfD, PAD, Level 

of Concern for 

Risk Assessment 

Study and Toxicological 

Effects 

Acute 

Dietary 

(General 

Population, 

including 

Infants and 

Children) 

NOAEL=125 

mg/kg/day 

UFA= 10x 

UFH= 10x 

FQPA SF= 1x 

Acute RfD = 1.25 

mg/kg/day 

aPAD =1.25 

mg/kg/day 

Developmental Toxicity Study 

in Rabbits 

LOAEL = 300 mg/kg/day 

based on clinical signs 

indicative of neurotoxicity in 

does (hypoactivity, prone 

position, panting, tremor and 

erythema) seen following the 

first dose on Gestation Day 6. 

Chronic 

Dietary (All 

Populations) NOAEL=99.7 

mg/kg/day 

UFA= 10x 

UFH= 10x 

FQPA SF= 1x 

Chronic RfD = 

1.0 

mg/kg/day 

cPAD = 1.0 

mg/kg/day 

Chronic 

Toxicity/Carcinogenicity 

Study in Rats 

LOAEL = 991 mg/kg/day 

based on decreased body 

weight gain and 

nephrotoxicity. 

Cancer Classification: “Not likely to be Carcinogenic to Humans” based on the 
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absence of significant tumor increases in two adequate rodent 

carcinogenicity studies. 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response 

data and used to mark the beginning of extrapolation to determine risk associated with lower 

environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest 

observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from animal to human 

(interspecies). UFH = potential variation in sensitivity among members of the human population 

(intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). 

RfD = reference dose. 

VI. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure and 

risk of the U.S. population and various population subgroups. The results reported in 

Table 7 are for the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 

years. 

Results of Acute and Chronic Dietary (Food and Drinking Water) Exposure and Risk 

Analyses

Acute dietary risk analyses were conducted with the DEEM-FCID model to form a 

conservative evaluation of exposure for dinotefuran. At the 95th percentile of exposure, 

all acute analyses yielded risk estimates well below the 100% of the aPAD threshold 

level of concern for each population subgroup. For the general U.S. population, acute 

aggregate dietary risk was 3.7% of the aPAD with an estimated exposure level of 

0.046286 mg/kg/day. For the subgroup with the highest exposure, children 1-2 years old, 

acute aggregate dietary risk occupied 12% of the aPAD with an estimated exposure of 

0.152112 mg/kg/day. An overview summarizing the results of the acute dietary 

assessments with the population subgroup having the highest exposure noted in bold is 

presented in Table 7. 

Chronic dietary risk analyses were conducted with the DEEM-FCID model to form a 

conservative evaluation of exposure for dinotefuran. All chronic analyses yielded risk 

estimates well below the 100% of the cPAD threshold level of concern for each 

population subgroup. For the general U.S. population, chronic aggregate dietary risk was 

1.7% of the cPAD with an estimated exposure level of 0.016633 mg/kg/day. For the 

subgroup with the highest exposure, children 1-2 years old, chronic aggregate dietary risk 

occupied 5.7% of the cPAD with an estimated exposure of 0.056650 mg/kg/day. An 

overview summarizing the results of the chronic dietary assessment with the population 

subgroup having the highest exposure noted in bold is presented in Table 7. 
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Table 7. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Dinotefuran.

Population Subgroup* 

Acute Dietary 

(95 th Percentile) Chronic Dietary 

Dietary 

Exposure 

(mg/kg/day) % aPAD** 

Dietary 

Exposure 

(mg/kg/day) % cPAD** 

General U.S. Population 0.046286 3.7 0.016633 1.7 

All Infants (< 1 year old) 0.132460 11 0.047675 4.8 

Children 1-2 years old* 0.152112 12 0.056650 5.7 

Children 3-5 years old 0.099267 7.9 0.037044 3.7 

Children 6-12 years old 0.051696 4.1 0.018991 1.9 

Youth 13-19 years old 0.031125 2.5 0.011261 1.1 

Adults 20-49 years old 0.034765 2.8 0.013944 1.4 

Adults 50-99 years old 0.031484 2.5 0.013404 1.3 

Females 13-49 years old 0.033791 2.7 0.013432 1.3 

*The subpopulation with the highest risk estimates is bolded.

VII. Characterization of Inputs/Outputs 

The acute screening-level dietary assessment conducted with DEEM-FCID for 

dinotefuran is an unrefined analysis. In addition to tolerance-level residues corrected for 

additional residues of concern for the risk assessment, default processing factors as 

appropriate, and 100% crop treated assumptions, it utilized conservative EDWCs derived 

through EFED modeling which are unlikely to underestimate the concentration of 

dinotefuran in drinking water. The present DEEM-FCID analysis assumes that all 

drinking water will contain dinotefuran at the highest acute EDWC levels modeled by 

EFED for groundwater or surface water. For these reasons, it can be concluded that the 

DEEM-FCID analysis does not underestimate risk from acute exposure to dinotefuran for 

the general U.S. population and all its subgroups. 

The chronic dietary assessment conducted with DEEM-FCID for dinotefuran is an 

unrefined analysis. In addition to tolerance-level residues corrected for additional 

residues of concern for the risk assessment, default processing factors, and 100% crop 

treated assumptions, it utilized conservative EDWCs derived through EFED modeling 

which are unlikely to underestimate the concentration of dinotefuran in drinking water. 

The present DEEM-FCID analysis assumes that all drinking water will contain 

dinotefuran at the highest chronic EDWC levels modeled by EFED for groundwater or 

surface water. For these reasons, it can be concluded that the DEEM-FCID analysis does 

not underestimate risk from chronic exposure to dinotefuran for the general U.S. 

population and all its subgroups. 
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VIII. Conclusions

The conservative acute screening-level dietary risk assessment conducted with DEEMFCID indicates that exposures to dinotefuran are below HED’s level of concern. The 

acute dietary risk to dinotefuran is estimated to be 3.7% of the aPAD for the general U.S. 

population and 12% of the aPAD for the most highly exposed population subgroup, 

children 1-2 years old. Therefore, HED does not have any concerns for the proposed 

Section 18 tolerances for dinotefuran. 

 

The conservative chronic dietary risk assessment conducted with DEEM-FCID indicates 

that exposures to dinotefuran are below HED’s level of concern. The chronic dietary risk 

to dinotefuran is estimated to be 1.7% of the cPAD for the general U.S. population and 

5.7% of the cPAD for the most highly exposed population subgroup, children 1-2 years 

old. Therefore, HED does not have any concerns for the proposed Section 18 tolerances 

for dinotefuran. 

 

IX. List of Attachments 

Attachment 1: Acute Residue Input File 

Attachment 2: Acute Results File 

Attachment 3: Chronic Residue Input File 

Attachment 4: Chronic Results File 
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Attachment 1: Acute Residue Input File 

Filename: C:\Documents and Settings\NDODD\My Documents\DEEM Version 3.16\Dinotefuran 

2013\Dinotefuran acute 042513.R08 

Chemical: Dinotefuran 

RfD(Chronic): 1 mg/kg bw/day NOEL(Chronic): 99.7 mg/kg bw/day 

RfD(Acute): 1.25 mg/kg bw/day NOEL(Acute): 125 mg/kg bw/day 

Date created/last modified: 04-25-2013/10:04:01 Program ver. 3.16, 03-08-d 

----------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ ------- 

0103015000 1CD Arrowroot, flour 0.050000 1.000 1.070 

0103015001 1CD Arrowroot, flour-babyfood 0.050000 1.000 1.070 

0103017000 1CD Artichoke, Jerusalem 0.050000 1.000 1.070 

0103082000 1CD Cassava 0.050000 1.000 1.070 

0103082001 1CD Cassava-babyfood 0.050000 1.000 1.070 

0103139000 1CD Dasheen, corm 0.050000 1.000 1.070 

0103166000 1CD Ginger 0.050000 1.000 1.070 

0103166001 1CD Ginger-babyfood 0.050000 1.000 1.070 

0103167000 1CD Ginger, dried 0.050000 1.000 1.070 

0103296000 1C Potato, chips 0.100000 1.000 1.070 

0103297000 1C Potato, dry (granules/ flakes) 0.150000 1.000 1.070 

0103297001 1C Potato, dry (granules/ flakes)-b 0.150000 1.000 1.070 

0103298000 1C Potato, flour 0.150000 1.000 1.070 

0103298001 1C Potato, flour-babyfood 0.150000 1.000 1.070 

0103299000 1C Potato, tuber, w/peel 0.050000 1.000 1.070 

0103299001 1C Potato, tuber, w/peel-babyfood 0.050000 1.000 1.070 

0103300000 1C Potato, tuber, w/o peel 0.050000 1.000 1.070 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.050000 1.000 1.070 

0103366000 1CD Sweet potato 0.050000 1.000 1.070 

0103366001 1CD Sweet potato-babyfood 0.050000 1.000 1.070 

0103371000 1CD Tanier, corm 0.050000 1.000 1.070 

0103387000 1CD Turmeric 0.050000 1.000 1.070 

0103406000 1CD Yam, true 0.050000 1.000 1.070 

0103407000 1CD Yam bean 0.050000 1.000 1.070 

0301165000 3A Garlic, bulb 0.150000 1.000 1.140 

0301165001 3A Garlic, bulb-babyfood 0.150000 1.000 1.140 

0301237000 3A Onion, bulb 0.150000 1.000 1.140 

0301237001 3A Onion, bulb-babyfood 0.150000 1.000 1.140 

0301238000 3A Onion, bulb, dried 0.150000 9.000 1.140 

0301238001 3A Onion, bulb, dried-babyfood 0.150000 9.000 1.140 

0301338000 3A Shallot, bulb 0.150000 1.000 1.140 

0302103000 3B Chive, fresh leaves 5.000000 1.000 1.140 

0302198000 3B Leek 5.000000 1.000 1.140 

0302239000 3B Onion, green 5.000000 1.000 1.140 

0302338500 3B Shallot, fresh leaves 5.000000 1.000 1.140 

0401005000 4A Amaranth, leafy 5.000000 1.000 1.050 

0401018000 4A Arugula 5.000000 1.000 1.050 

0401104000 4A Chrysanthemum, garland 5.000000 1.000 1.050 

0401133000 4A Cress, garden 5.000000 1.000 1.050 

0401134000 4A Cress, upland 5.000000 1.000 1.050 

0401138000 4A Dandelion, leaves 5.000000 1.000 1.050 

0401150000 4A Endive 5.000000 1.000 1.050 

0401204000 4A Lettuce, head 5.000000 1.000 1.050 

0401205000 4A Lettuce, leaf 5.000000 1.000 1.050 

0401248000 4A Parsley, leaves 5.000000 1.000 1.050 

0401313000 4A Radicchio 5.000000 1.000 1.050 

0401355000 4A Spinach 5.000000 1.000 1.050 

0401355001 4A Spinach-babyfood 5.000000 1.000 1.050 

0402076000 4B Cardoon 5.000000 1.000 1.050 

0402085000 4B Celery 5.000000 1.000 1.050 

0402085001 4B Celery-babyfood 5.000000 1.000 1.050 

0402086000 4B Celery, juice 5.000000 1.000 1.050 

0402087000 4B Celtuce 5.000000 1.000 1.050 

0402152000 4B Fennel, Florence 5.000000 1.000 1.050 

0402322000 4B Rhubarb 5.000000 1.000 1.050 

0402367000 4B Swiss chard 5.000000 1.000 1.050 

0501061000 5A Broccoli 1.400000 1.000 1.140 

0501061001 5A Broccoli-babyfood 1.400000 1.000 1.140 

0501062000 5A Broccoli, Chinese 1.400000 1.000 1.140 

0501064000 5A Brussels sprouts 1.400000 1.000 1.140 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 13 of 25 

0501069000 5A Cabbage 1.400000 1.000 1.140 

0501071000 5A Cabbage, Chinese, napa 1.400000 1.000 1.140 

0501072000 5A Cabbage, Chinese, mustard 1.400000 1.000 1.140 

0501083000 5A Cauliflower 1.400000 1.000 1.140 

0501196000 5A Kohlrabi 1.400000 1.000 1.140 

0502063000 5B Broccoli raab 15.000000 1.000 1.140 

0502070000 5B Cabbage, Chinese, bok choy 15.000000 1.000 1.140 

0502117000 5B Collards 15.000000 1.000 1.140 

0502194000 5B Kale 15.000000 1.000 1.140 

0502229000 5B Mustard greens 15.000000 1.000 1.140 

0502318000 5B Rape greens 15.000000 1.000 1.140 

0502389000 5B Turnip, greens 15.000000 1.000 1.140 

0801374000 8A Tomatillo 0.700000 1.000 1.140 

0801375000 8A Tomato 0.700000 1.000 1.140 

0801375001 8A Tomato-babyfood 0.700000 1.000 1.140 

0801376000 8A Tomato, paste 1.000000 1.000 1.140 

0801376001 8A Tomato, paste-babyfood 1.000000 1.000 1.140 

0801377000 8A Tomato, puree 0.700000 1.000 1.140 D29019 

 Full comment: D290191 

0801377001 8A Tomato, puree-babyfood 0.700000 1.000 1.140 

0801378000 8A Tomato, dried 0.700000 14.300 1.140 

0801378001 8A Tomato, dried-babyfood 0.700000 14.300 1.140 

0801379000 8A Tomato, juice 0.700000 1.500 1.140 

0801380000 8A Tomato, Tree 0.700000 1.000 1.140 

0802148000 8BC Eggplant 0.700000 1.000 1.140 

0802234000 8BC Okra 0.700000 1.000 1.140 

0802270000 8B Pepper, bell 0.700000 1.000 1.140 

0802270001 8B Pepper, bell-babyfood 0.700000 1.000 1.140 

0802271000 8B Pepper, bell, dried 0.700000 1.000 1.140 

0802271001 8B Pepper, bell, dried-babyfood 0.700000 1.000 1.140 

0802272000 8BC Pepper, nonbell 0.700000 1.000 1.140 

0802272001 8BC Pepper, nonbell-babyfood 0.700000 1.000 1.140 

0802273000 8BC Pepper, nonbell, dried 0.700000 1.000 1.140 

0901075000 9A Cantaloupe 0.500000 1.000 1.140 

0901187000 9A Honeydew melon 0.500000 1.000 1.140 

0901399000 9A Watermelon 0.500000 1.000 1.140 

0901400000 9A Watermelon, juice 0.500000 1.000 1.140 

0902021000 9B Balsam pear 0.500000 1.000 1.140 

0902088000 9B Chayote, fruit 0.500000 1.000 1.140 

0902102000 9B Chinese waxgourd 0.500000 1.000 1.140 

0902135000 9B Cucumber 0.500000 1.000 1.140 

0902308000 9B Pumpkin 0.500000 1.000 1.140 

0902309000 9B Pumpkin, seed 0.500000 1.000 1.140 

0902356000 9B Squash, summer 0.500000 1.000 1.140 

0902356001 9B Squash, summer-babyfood 0.500000 1.000 1.140 

0902357000 9B Squash, winter 0.500000 1.000 1.140 

0902357001 9B Squash, winter-babyfood 0.500000 1.000 1.140 

1100007000 11 Apple, fruit with peel 2.000000 1.000 1.140 

1100008000 11 Apple, peeled fruit 2.000000 1.000 1.140 

1100008001 11 Apple, peeled fruit-babyfood 2.000000 1.000 1.140 

1100009000 11 Apple, dried 2.000000 8.000 1.140 

1100009001 11 Apple, dried-babyfood 2.000000 8.000 1.140 

1100010000 11 Apple, juice 2.000000 1.300 1.140 Sectio 

 Full comment: Section 18 

1100010001 11 Apple, juice-babyfood 2.000000 1.300 1.140 

1100011000 11 Apple, sauce 2.000000 1.000 1.140 

1100011001 11 Apple, sauce-babyfood 2.000000 1.000 1.140 

1100129000 11 Crabapple 2.000000 1.000 1.140 

1100173500 11 Goji berry 0.700000 1.000 1.140 

1100210000 11 Loquat 2.000000 1.000 1.140 

1100266000 11 Pear 2.000000 1.000 1.140 

1100266001 11 Pear-babyfood 2.000000 1.000 1.140 

1100267000 11 Pear, dried 2.000000 6.250 1.140 

1100268000 11 Pear, juice 2.000000 1.000 1.140 

1100268001 11 Pear, juice-babyfood 2.000000 1.000 1.140 

1100310000 11 Quince 2.000000 1.000 1.140 

1201090000 12A Cherry 2.000000 1.000 1.140 

1201090001 12A Cherry-babyfood 2.000000 1.000 1.140 

1201091000 12A Cherry, juice 2.000000 1.500 1.140 

1201091001 12A Cherry, juice-babyfood 2.000000 1.500 1.140 

1202012000 12B Apricot 2.000000 1.000 1.140 

1202012001 12B Apricot-babyfood 2.000000 1.000 1.140 

1202013000 12B Apricot, dried 2.000000 6.000 1.140 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 14 of 25 

1202014000 12B Apricot, juice 2.000000 1.000 1.140 

1202014001 12B Apricot, juice-babyfood 2.000000 1.000 1.140 

1202230000 12B Nectarine 2.000000 1.000 1.140 

1202260000 12B Peach 2.000000 1.000 1.140 

1202260001 12B Peach-babyfood 2.000000 1.000 1.140 

1202261000 12B Peach, dried 2.000000 7.000 1.140 

1202261001 12B Peach, dried-babyfood 2.000000 7.000 1.140 

1202262000 12B Peach, juice 2.000000 1.000 1.140 

1202262001 12B Peach, juice-babyfood 2.000000 1.000 1.140 

1203285000 12C Plum 2.000000 1.000 1.140 

1203285001 12C Plum-babyfood 2.000000 1.000 1.140 

1203286000 12C Plum, prune, fresh 2.000000 1.000 1.140 

1203286001 12C Plum, prune, fresh-babyfood 2.000000 1.000 1.140 

1203287000 12C Plum, prune, dried 2.000000 5.000 1.140 Sectio 

 Full comment: Section 18 

1203287001 12C Plum, prune, dried-babyfood 2.000000 5.000 1.140 

1203288000 12C Plum, prune, juice 2.000000 1.400 1.140 

1203288001 12C Plum, prune, juice-babyfood 2.000000 1.400 1.140 

1302057000 13B Blueberry 0.200000 1.000 1.140 

1302057001 13B Blueberry-babyfood 0.200000 1.000 1.140 

1302174000 13B Gooseberry 0.900000 1.000 1.140 

1304175000 13D Grape 0.900000 1.000 1.140 

1304176000 13D Grape, juice 0.900000 1.000 1.140 D29019 

 Full comment: D290191 

1304176001 13D Grape, juice-babyfood 0.900000 1.000 1.140 

1304179000 13D Grape, wine and sherry 0.900000 1.000 1.140 

1307130000 13G Cranberry 0.200000 1.000 1.140 

1307130001 13G Cranberry-babyfood 0.200000 1.000 1.140 

1307131000 13G Cranberry, dried 0.200000 1.000 1.140 

1307132000 13G Cranberry, juice 0.200000 1.100 1.140 

1307132001 13G Cranberry, juice-babyfood 0.200000 1.100 1.140 

1500323000 15 Rice, white 9.000000 1.000 1.070 

1500323001 15 Rice, white-babyfood 9.000000 1.000 1.070 

1500324000 15 Rice, brown 9.000000 1.000 1.070 

1500324001 15 Rice, brown-babyfood 9.000000 1.000 1.070 

1500325000 15 Rice, flour 9.000000 1.000 1.070 

1500325001 15 Rice, flour-babyfood 9.000000 1.000 1.070 

1500326000 15 Rice, bran 9.000000 1.000 1.070 

1500326001 15 Rice, bran-babyfood 9.000000 1.000 1.070 

2003128000 20C Cottonseed, oil 0.400000 1.000 1.070 

2003128001 20C Cottonseed, oil-babyfood 0.400000 1.000 1.070 

3100044000 31 Beef, meat 0.050000 1.000 1.210 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.210 

3100045000 31 Beef, meat, dried 0.050000 1.920 1.210 

3100046000 31 Beef, meat byproducts 0.050000 1.000 1.280 

3100046001 31 Beef, meat byproducts-babyfood 0.050000 1.000 1.280 

3100047000 31 Beef, fat 0.050000 1.000 1.100 

3100047001 31 Beef, fat-babyfood 0.050000 1.000 1.100 

3100048000 31 Beef, kidney 0.050000 1.000 1.280 

3100049000 31 Beef, liver 0.050000 1.000 1.280 

3100049001 31 Beef, liver-babyfood 0.050000 1.000 1.280 

3200169000 32 Goat, meat 0.050000 1.000 1.210 

3200170000 32 Goat, meat byproducts 0.050000 1.000 1.280 

3200171000 32 Goat, fat 0.050000 1.000 1.100 

3200172000 32 Goat, kidney 0.050000 1.000 1.280 

3200173000 32 Goat, liver 0.050000 1.000 1.280 

3300189000 33 Horse, meat 0.050000 1.000 1.210 

3400290000 34 Pork, meat 0.050000 1.000 1.210 

3400290001 34 Pork, meat-babyfood 0.050000 1.000 1.210 

3400291000 34 Pork, skin 0.050000 1.000 1.280 

3400292000 34 Pork, meat byproducts 0.050000 1.000 1.280 

3400292001 34 Pork, meat byproducts-babyfood 0.050000 1.000 1.280 

3400293000 34 Pork, fat 0.050000 1.000 1.100 

3400293001 34 Pork, fat-babyfood 0.050000 1.000 1.100 

3400294000 34 Pork, kidney 0.050000 1.000 1.280 

3400295000 34 Pork, liver 0.050000 1.000 1.280 

3500339000 35 Sheep, meat 0.050000 1.000 1.210 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.210 

3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.280 

3500341000 35 Sheep, fat 0.050000 1.000 1.100 

3500341001 35 Sheep, fat-babyfood 0.050000 1.000 1.100 

3500342000 35 Sheep, kidney 0.050000 1.000 1.280 

3500343000 35 Sheep, liver 0.050000 1.000 1.280 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 15 of 25 

3600222000 36 Milk, fat 0.050000 1.000 1.160 

3600222001 36 Milk, fat-baby food/infant formu 0.050000 1.000 1.160 

3600223000 36 Milk, nonfat solids 0.050000 1.000 1.160 

3600223001 36 Milk, nonfat solids-baby food/in 0.050000 1.000 1.160 

3600224000 36 Milk, water 0.050000 1.000 1.160 

3600224001 36 Milk, water-babyfood/infant form 0.050000 1.000 1.160 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.160 

4000094000 40 Chicken, liver 0.010000 1.000 1.060 

4000095000 40 Chicken, meat byproducts 0.010000 1.000 1.060 

4000095001 40 Chicken, meat byproducts-babyfoo 0.010000 1.000 1.060 

4000097000 40 Chicken, skin 0.010000 1.000 1.060 

4000097001 40 Chicken, skin-babyfood 0.010000 1.000 1.060 

5000383000 50 Turkey, liver 0.010000 1.000 1.060 

5000383001 50 Turkey, liver-babyfood 0.010000 1.000 1.060 

5000384000 50 Turkey, meat byproducts 0.010000 1.000 1.060 

5000384001 50 Turkey, meat byproducts-babyfood 0.010000 1.000 1.060 

5000386000 50 Turkey, skin 0.010000 1.000 1.060 

5000386001 50 Turkey, skin-babyfood 0.010000 1.000 1.060 

6000302000 60 Poultry, other, liver 0.010000 1.000 1.060 

6000303000 60 Poultry, other, meat byproducts 0.010000 1.000 1.060 

6000305000 60 Poultry, other, skin 0.010000 1.000 1.060 

7000145000 70 Egg, whole 0.010000 1.000 1.100 

7000145001 70 Egg, whole-babyfood 0.010000 1.000 1.100 

7000146000 70 Egg, white 0.010000 1.000 1.100 

7000146001 70 Egg, white (solids)-babyfood 0.010000 1.000 1.100 

7000147000 70 Egg, yolk 0.010000 1.000 1.100 

7000147001 70 Egg, yolk-babyfood 0.010000 1.000 1.100 

8601000000 86A Water, direct, all sources 0.269000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.269000 1.000 1.000 

9500177000 O Grape, leaves 0.900000 1.000 1.140 

9500178000 O Grape, raisin 2.500000 1.000 1.140 

9500372000 O Tea, dried 50.000000 1.000 1.140 

9500373000 O Tea, instant 50.000000 1.000 1.140 

9500398000 O Watercress 8.000000 1.000 1.140 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 16 of 25 

Attachment 2: Acute Results File 

U.S. EPA Ver. 3.16, 03-08-d 

DEEM-FCID ACUTE Analysis for DINOTEFURAN NHANES 2003-2008 2-Day 

Residue file: Dinotefuran acute 042513.R08 Adjustment factor #2 used. 

Analysis Date: 04-25-2013/10:05:53 Residue file dated: 04-25-2013/10:04:01 

NOEL (Acute) = 125.000000 mg/kg body-wt/day 

RAC/FF intake summed over 24 hours 

Run Comment: "" 

=============================================================================== 

Summary calculations--per capita: 

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile---- 

 Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- 

Total US Population: 

 0.046286 3.70 2700 0.095806 7.66 1304 0.202291 16.18 617 

All Infants: 

 0.132460 10.60 943 0.207078 16.57 603 0.325585 26.05 383 

Children 1-2: 

 0.152112 12.17 821 0.236367 18.91 528 0.382991 30.64 326 

Children 3-5: 

 0.099267 7.94 1259 0.155523 12.44 803 0.238357 19.07 524 

Children 6-12: 

 0.051696 4.14 2417 0.091500 7.32 1366 0.163874 13.11 762 

Youth 13-19: 

 0.031125 2.49 4016 0.050792 4.06 2461 0.074714 5.98 1673 

Adults 20-49: 

 0.034765 2.78 3595 0.053555 4.28 2334 0.087480 7.00 1428 

Adults 50-99: 

 0.031484 2.52 3970 0.046971 3.76 2661 0.085766 6.86 1457 

Female 13-49: 

 0.033791 2.70 3699 0.050648 4.05 2468 0.079495 6.36 1572 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 17 of 25 

Attachment 3: Chronic Residue Input File 

Filename: C:\Documents and Settings\NDODD\My Documents\DEEM Version 3.16\Dinotefuran 

2013\Dinotefuran chronic 042513.R08 

Chemical: Dinotefuran 

RfD(Chronic): 1 mg/kg bw/day NOEL(Chronic): 99.7 mg/kg bw/day 

RfD(Acute): 1.25 mg/kg bw/day NOEL(Acute): 125 mg/kg bw/day 

Date created/last modified: 04-25-2013/10:15:24 Program ver. 3.16, 03-08-d 

Comment: Acute and Chronic Dietary (food+drinking water) Assessment 

----------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ ------- 

0101050000 1AB Beet, garden, roots 0.010000 1.000 1.140 

0101050001 1AB Beet, garden, roots-babyfood 0.010000 1.000 1.140 

0101052000 1A Beet, sugar 0.010000 1.000 1.140 

0101052001 1A Beet, sugar-babyfood 0.010000 1.000 1.140 

0101053000 1A Beet, sugar, molasses 0.010000 1.000 1.140 

0101053001 1A Beet, sugar, molasses-babyfood 0.010000 1.000 1.140 

0101067000 1AB Burdock 0.010000 1.000 1.140 

0101078000 1AB Carrot 0.010000 1.000 1.140 

0101078001 1AB Carrot-babyfood 0.010000 1.000 1.140 

0101079000 1AB Carrot, juice 0.010000 1.000 1.140 

0101084000 1AB Celeriac 0.010000 1.000 1.140 

0101100000 1AB Chicory, roots 0.010000 1.000 1.140 

0101168000 1AB Ginseng, dried 0.010000 1.000 1.140 

0101190000 1AB Horseradish 0.010000 1.000 1.140 

0101250000 1AB Parsley, turnip rooted 0.010000 1.000 1.140 

0101251000 1AB Parsnip 0.010000 1.000 1.140 

0101251001 1AB Parsnip-babyfood 0.010000 1.000 1.140 

0101314000 1AB Radish, roots 0.010000 1.000 1.140 

0101316000 1AB Radish, Oriental, roots 0.010000 1.000 1.140 

0101327000 1AB Rutabaga 0.010000 1.000 1.140 

0101331000 1AB Salsify, roots 0.010000 1.000 1.140 

0101388000 1AB Turnip, roots 0.010000 1.000 1.140 

0103015000 1CD Arrowroot, flour 0.050000 1.000 1.070 

0103015001 1CD Arrowroot, flour-babyfood 0.050000 1.000 1.070 

0103017000 1CD Artichoke, Jerusalem 0.050000 1.000 1.070 

0103082000 1CD Cassava 0.050000 1.000 1.070 

0103082001 1CD Cassava-babyfood 0.050000 1.000 1.070 

0103139000 1CD Dasheen, corm 0.050000 1.000 1.070 

0103166000 1CD Ginger 0.050000 1.000 1.070 

0103166001 1CD Ginger-babyfood 0.050000 1.000 1.070 

0103167000 1CD Ginger, dried 0.050000 1.000 1.070 

0103296000 1C Potato, chips 0.100000 1.000 1.070 

0103297000 1C Potato, dry (granules/ flakes) 0.150000 1.000 1.070 

0103297001 1C Potato, dry (granules/ flakes)-b 0.150000 1.000 1.070 

0103298000 1C Potato, flour 0.150000 1.000 1.070 

0103298001 1C Potato, flour-babyfood 0.150000 1.000 1.070 

0103299000 1C Potato, tuber, w/peel 0.050000 1.000 1.070 

0103299001 1C Potato, tuber, w/peel-babyfood 0.050000 1.000 1.070 

0103300000 1C Potato, tuber, w/o peel 0.050000 1.000 1.070 

0103300001 1C Potato, tuber, w/o peel-babyfood 0.050000 1.000 1.070 

0103366000 1CD Sweet potato 0.050000 1.000 1.070 

0103366001 1CD Sweet potato-babyfood 0.050000 1.000 1.070 

0103371000 1CD Tanier, corm 0.050000 1.000 1.070 

0103387000 1CD Turmeric 0.050000 1.000 1.070 

0103406000 1CD Yam, true 0.050000 1.000 1.070 

0103407000 1CD Yam bean 0.050000 1.000 1.070 

0200051000 2 Beet, garden, tops 0.010000 1.000 1.140 

0200101000 2 Chicory, tops 0.010000 1.000 1.140 

0200140000 2 Dasheen, leaves 0.010000 1.000 1.140 

0200315000 2 Radish, tops 0.010000 1.000 1.140 

0200317000 2 Radish, Oriental, tops 0.010000 1.000 1.140 

0200332000 2 Salsify, tops 0.010000 1.000 1.140 

0301165000 3A Garlic, bulb 0.150000 1.000 1.140 

0301165001 3A Garlic, bulb-babyfood 0.150000 1.000 1.140 

0301237000 3A Onion, bulb 0.150000 1.000 1.140 

0301237001 3A Onion, bulb-babyfood 0.150000 1.000 1.140 

0301238000 3A Onion, bulb, dried 0.150000 9.000 1.140 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 18 of 25 

0301238001 3A Onion, bulb, dried-babyfood 0.150000 9.000 1.140 

0301338000 3A Shallot, bulb 0.150000 1.000 1.140 

0302103000 3B Chive, fresh leaves 5.000000 1.000 1.140 

0302198000 3B Leek 5.000000 1.000 1.140 

0302239000 3B Onion, green 5.000000 1.000 1.140 

0302338500 3B Shallot, fresh leaves 5.000000 1.000 1.140 

0401005000 4A Amaranth, leafy 5.000000 1.000 1.050 

0401018000 4A Arugula 5.000000 1.000 1.050 

0401104000 4A Chrysanthemum, garland 5.000000 1.000 1.050 

0401133000 4A Cress, garden 5.000000 1.000 1.050 

0401134000 4A Cress, upland 5.000000 1.000 1.050 

0401138000 4A Dandelion, leaves 5.000000 1.000 1.050 

0401150000 4A Endive 5.000000 1.000 1.050 

0401204000 4A Lettuce, head 5.000000 1.000 1.050 

0401205000 4A Lettuce, leaf 5.000000 1.000 1.050 

0401248000 4A Parsley, leaves 5.000000 1.000 1.050 

0401313000 4A Radicchio 5.000000 1.000 1.050 

0401355000 4A Spinach 5.000000 1.000 1.050 

0401355001 4A Spinach-babyfood 5.000000 1.000 1.050 

0402076000 4B Cardoon 5.000000 1.000 1.050 

0402085000 4B Celery 5.000000 1.000 1.050 

0402085001 4B Celery-babyfood 5.000000 1.000 1.050 

0402086000 4B Celery, juice 5.000000 1.000 1.050 

0402087000 4B Celtuce 5.000000 1.000 1.050 

0402152000 4B Fennel, Florence 5.000000 1.000 1.050 

0402322000 4B Rhubarb 5.000000 1.000 1.050 

0402367000 4B Swiss chard 5.000000 1.000 1.050 

0501061000 5A Broccoli 1.400000 1.000 1.140 

0501061001 5A Broccoli-babyfood 1.400000 1.000 1.140 

0501062000 5A Broccoli, Chinese 1.400000 1.000 1.140 

0501064000 5A Brussels sprouts 1.400000 1.000 1.140 

0501069000 5A Cabbage 1.400000 1.000 1.140 

0501071000 5A Cabbage, Chinese, napa 1.400000 1.000 1.140 

0501072000 5A Cabbage, Chinese, mustard 1.400000 1.000 1.140 

0501083000 5A Cauliflower 1.400000 1.000 1.140 

0501196000 5A Kohlrabi 1.400000 1.000 1.140 

0502063000 5B Broccoli raab 15.000000 1.000 1.140 

0502070000 5B Cabbage, Chinese, bok choy 15.000000 1.000 1.140 

0502117000 5B Collards 15.000000 1.000 1.140 

0502194000 5B Kale 15.000000 1.000 1.140 

0502229000 5B Mustard greens 15.000000 1.000 1.140 

0502318000 5B Rape greens 15.000000 1.000 1.140 

0502389000 5B Turnip, greens 15.000000 1.000 1.140 

0600347000 6 Soybean, seed 0.010000 1.000 1.140 

0600349000 6 Soybean, soy milk 0.010000 1.000 1.140 

0600349001 6 Soybean, soy milk-babyfood or in 0.010000 1.000 1.140 

0600350000 6 Soybean, oil 0.010000 1.000 1.140 

0600350001 6 Soybean, oil-babyfood 0.010000 1.000 1.140 

0601043000 6A Bean, snap, succulent 0.010000 1.000 1.140 

0601043001 6A Bean, snap, succulent-babyfood 0.010000 1.000 1.140 

0601257000 6A Pea, edible podded, succulent 0.010000 1.000 1.140 

0601349500 6AB Soybean, vegetable 0.010000 1.000 1.140 

0602031000 6B Bean, broad, succulent 0.010000 1.000 1.140 

0602033000 6B Bean, cowpea, succulent 0.010000 1.000 1.140 

0602037000 6B Bean, lima, succulent 0.010000 1.000 1.140 

0602255000 6B Pea, succulent 0.010000 1.000 1.140 

0602255001 6B Pea, succulent-babyfood 0.010000 1.000 1.140 

0602259000 6B Pea, pigeon, succulent 0.010000 1.000 1.140 

0603030000 6C Bean, black, seed 0.010000 1.000 1.140 

0603032000 6C Bean, broad, seed 0.010000 1.000 1.140 

0603034000 6C Bean, cowpea, seed 0.010000 1.000 1.140 

0603035000 6C Bean, great northern, seed 0.010000 1.000 1.140 

0603036000 6C Bean, kidney, seed 0.010000 1.000 1.140 

0603038000 6C Bean, lima, seed 0.010000 1.000 1.140 

0603039000 6C Bean, mung, seed 0.010000 1.000 1.140 

0603040000 6C Bean, navy, seed 0.010000 1.000 1.140 

0603041000 6C Bean, pink, seed 0.010000 1.000 1.140 

0603042000 6C Bean, pinto, seed 0.010000 1.000 1.140 

0603098000 6C Chickpea, seed 0.010000 1.000 1.140 

0603098001 6C Chickpea, seed-babyfood 0.010000 1.000 1.140 

0603099000 6C Chickpea, flour 0.010000 1.000 1.140 

0603182000 6C Guar, seed 0.010000 1.000 1.140 

0603182001 6C Guar, seed-babyfood 0.010000 1.000 1.140 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 19 of 25 

0603203000 6C Lentil, seed 0.010000 1.000 1.140 

0603256000 6C Pea, dry 0.010000 1.000 1.140 

0603256001 6C Pea, dry-babyfood 0.010000 1.000 1.140 

0603258000 6C Pea, pigeon, seed 0.010000 1.000 1.140 

0603348000 6C Soybean, flour 0.010000 1.000 1.140 

0603348001 6C Soybean, flour-babyfood 0.010000 1.000 1.140 

0801374000 8A Tomatillo 0.700000 1.000 1.140 

0801375000 8A Tomato 0.700000 1.000 1.140 

0801375001 8A Tomato-babyfood 0.700000 1.000 1.140 

0801376000 8A Tomato, paste 1.000000 1.000 1.140 

0801376001 8A Tomato, paste-babyfood 1.000000 1.000 1.140 

0801377000 8A Tomato, puree 0.700000 1.000 1.140 D29019 

 Full comment: D290191 

0801377001 8A Tomato, puree-babyfood 0.700000 1.000 1.140 

0801378000 8A Tomato, dried 0.700000 14.300 1.140 

0801378001 8A Tomato, dried-babyfood 0.700000 14.300 1.140 

0801379000 8A Tomato, juice 0.700000 1.500 1.140 

0801380000 8A Tomato, Tree 0.700000 1.000 1.140 

0802148000 8BC Eggplant 0.700000 1.000 1.140 

0802234000 8BC Okra 0.700000 1.000 1.140 

0802270000 8B Pepper, bell 0.700000 1.000 1.140 

0802270001 8B Pepper, bell-babyfood 0.700000 1.000 1.140 

0802271000 8B Pepper, bell, dried 0.700000 1.000 1.140 

0802271001 8B Pepper, bell, dried-babyfood 0.700000 1.000 1.140 

0802272000 8BC Pepper, nonbell 0.700000 1.000 1.140 

0802272001 8BC Pepper, nonbell-babyfood 0.700000 1.000 1.140 

0802273000 8BC Pepper, nonbell, dried 0.700000 1.000 1.140 

0901075000 9A Cantaloupe 0.500000 1.000 1.140 

0901187000 9A Honeydew melon 0.500000 1.000 1.140 

0901399000 9A Watermelon 0.500000 1.000 1.140 

0901400000 9A Watermelon, juice 0.500000 1.000 1.140 

0902021000 9B Balsam pear 0.500000 1.000 1.140 

0902088000 9B Chayote, fruit 0.500000 1.000 1.140 

0902102000 9B Chinese waxgourd 0.500000 1.000 1.140 

0902135000 9B Cucumber 0.500000 1.000 1.140 

0902308000 9B Pumpkin 0.500000 1.000 1.140 

0902309000 9B Pumpkin, seed 0.500000 1.000 1.140 

0902356000 9B Squash, summer 0.500000 1.000 1.140 

0902356001 9B Squash, summer-babyfood 0.500000 1.000 1.140 

0902357000 9B Squash, winter 0.500000 1.000 1.140 

0902357001 9B Squash, winter-babyfood 0.500000 1.000 1.140 

1001106000 10A Citron 0.010000 1.000 1.140 

1001107000 10A Citrus hybrids 0.010000 1.000 1.140 

1001108000 10A Citrus, oil 0.010000 1.000 1.140 

1001240000 10A Orange 0.010000 1.000 1.140 

1001241000 10A Orange, juice 0.010000 1.000 1.140 

1001241001 10A Orange, juice-babyfood 0.010000 1.000 1.140 

1001242000 10A Orange, peel 0.010000 1.000 1.140 

1001369000 10A Tangerine 0.010000 1.000 1.140 

1001370000 10A Tangerine, juice 0.010000 1.000 1.140 

1002197000 10B Kumquat 0.010000 1.000 1.140 

1002199000 10B Lemon 0.010000 1.000 1.140 

1002200000 10B Lemon, juice 0.010000 1.000 1.140 

1002200001 10B Lemon, juice-babyfood 0.010000 1.000 1.140 

1002201000 10B Lemon, peel 0.010000 1.000 1.140 

1002206000 10B Lime 0.010000 1.000 1.140 

1002207000 10B Lime, juice 0.010000 1.000 1.140 

1002207001 10B Lime, juice-babyfood 0.010000 1.000 1.140 

1003180000 10C Grapefruit 0.010000 1.000 1.140 

1003181000 10C Grapefruit, juice 0.010000 1.000 1.140 

1003307000 10C Pummelo 0.010000 1.000 1.140 

1100007000 11 Apple, fruit with peel 2.000000 1.000 1.140 

1100008000 11 Apple, peeled fruit 2.000000 1.000 1.140 

1100008001 11 Apple, peeled fruit-babyfood 2.000000 1.000 1.140 

1100009000 11 Apple, dried 2.000000 8.000 1.140 

1100009001 11 Apple, dried-babyfood 2.000000 8.000 1.140 

1100010000 11 Apple, juice 2.000000 1.300 1.140 Sectio 

 Full comment: Section 18 

1100010001 11 Apple, juice-babyfood 2.000000 1.300 1.140 

1100011000 11 Apple, sauce 2.000000 1.000 1.140 

1100011001 11 Apple, sauce-babyfood 2.000000 1.000 1.140 

1100129000 11 Crabapple 2.000000 1.000 1.140 

1100173500 11 Goji berry 0.700000 1.000 1.140 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 20 of 25 

1100210000 11 Loquat 2.000000 1.000 1.140 

1100266000 11 Pear 2.000000 1.000 1.140 

1100266001 11 Pear-babyfood 2.000000 1.000 1.140 

1100267000 11 Pear, dried 2.000000 6.250 1.140 

1100268000 11 Pear, juice 2.000000 1.000 1.140 

1100268001 11 Pear, juice-babyfood 2.000000 1.000 1.140 

1100310000 11 Quince 2.000000 1.000 1.140 

1201090000 12A Cherry 2.000000 1.000 1.140 

1201090001 12A Cherry-babyfood 2.000000 1.000 1.140 

1201091000 12A Cherry, juice 2.000000 1.500 1.140 

1201091001 12A Cherry, juice-babyfood 2.000000 1.500 1.140 

1202012000 12B Apricot 2.000000 1.000 1.140 

1202012001 12B Apricot-babyfood 2.000000 1.000 1.140 

1202013000 12B Apricot, dried 2.000000 6.000 1.140 

1202014000 12B Apricot, juice 2.000000 1.000 1.140 

1202014001 12B Apricot, juice-babyfood 2.000000 1.000 1.140 

1202230000 12B Nectarine 2.000000 1.000 1.140 

1202260000 12B Peach 2.000000 1.000 1.140 

1202260001 12B Peach-babyfood 2.000000 1.000 1.140 

1202261000 12B Peach, dried 2.000000 7.000 1.140 

1202261001 12B Peach, dried-babyfood 2.000000 7.000 1.140 

1202262000 12B Peach, juice 2.000000 1.000 1.140 

1202262001 12B Peach, juice-babyfood 2.000000 1.000 1.140 

1203285000 12C Plum 2.000000 1.000 1.140 

1203285001 12C Plum-babyfood 2.000000 1.000 1.140 

1203286000 12C Plum, prune, fresh 2.000000 1.000 1.140 

1203286001 12C Plum, prune, fresh-babyfood 2.000000 1.000 1.140 

1203287000 12C Plum, prune, dried 2.000000 5.000 1.140 Sectio 

 Full comment: Section 18 

1203287001 12C Plum, prune, dried-babyfood 2.000000 5.000 1.140 

1203288000 12C Plum, prune, juice 2.000000 1.400 1.140 

1203288001 12C Plum, prune, juice-babyfood 2.000000 1.400 1.140 

1301055000 13A Blackberry 0.010000 1.000 1.140 

1301056000 13A Blackberry, juice 0.010000 1.000 1.140 

1301056001 13A Blackberry, juice-babyfood 0.010000 1.000 1.140 

1301058000 13A Boysenberry 0.010000 1.000 1.140 

1301208000 13A Loganberry 0.010000 1.000 1.140 

1301320000 13A Raspberry 0.010000 1.000 1.140 

1301320001 13A Raspberry-babyfood 0.010000 1.000 1.140 

1301321000 13A Raspberry, juice 0.010000 1.000 1.140 

1301321001 13A Raspberry, juice-babyfood 0.010000 1.000 1.140 

1302057000 13B Blueberry 0.200000 1.000 1.140 

1302057001 13B Blueberry-babyfood 0.200000 1.000 1.140 

1302136000 13B Currant 0.010000 1.000 1.140 

1302137000 13B Currant, dried 0.010000 1.000 1.140 

1302149000 13B Elderberry 0.010000 1.000 1.140 

1302174000 13B Gooseberry 0.900000 1.000 1.140 

1302191000 13B Huckleberry 0.010000 1.000 1.140 

1303227000 13C Mulberry 0.010000 1.000 1.140 

1304175000 13D Grape 0.900000 1.000 1.140 

1304176000 13D Grape, juice 0.900000 1.000 1.140 D29019 

 Full comment: D290191 

1304176001 13D Grape, juice-babyfood 0.900000 1.000 1.140 

1304179000 13D Grape, wine and sherry 0.900000 1.000 1.140 

1304195000 13D Kiwifruit, fuzzy 0.010000 1.000 1.140 

1307130000 13G Cranberry 0.200000 1.000 1.140 

1307130001 13G Cranberry-babyfood 0.200000 1.000 1.140 

1307131000 13G Cranberry, dried 0.200000 1.000 1.140 

1307132000 13G Cranberry, juice 0.200000 1.100 1.140 

1307132001 13G Cranberry, juice-babyfood 0.200000 1.100 1.140 

1307359000 13G Strawberry 0.010000 1.000 1.140 

1307359001 13G Strawberry-babyfood 0.010000 1.000 1.140 

1307360000 13G Strawberry, juice 0.010000 1.000 1.140 

1307360001 13G Strawberry, juice-babyfood 0.010000 1.000 1.140 

1400003000 14 Almond 0.010000 1.000 1.140 

1400003001 14 Almond-babyfood 0.010000 1.000 1.140 

1400004000 14 Almond, oil 0.010000 1.000 1.140 

1400004001 14 Almond, oil-babyfood 0.010000 1.000 1.140 

1400059000 14 Brazil nut 0.010000 1.000 1.140 

1400068000 14 Butternut 0.010000 1.000 1.140 

1400081000 14 Cashew 0.010000 1.000 1.140 

1400092000 14 Chestnut 0.010000 1.000 1.140 

1400155000 14 Hazelnut 0.010000 1.000 1.140 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 21 of 25 

1400156000 14 Hazelnut, oil 0.010000 1.000 1.140 

1400185000 14 Hickory nut 0.010000 1.000 1.140 

1400213000 14 Macadamia nut 0.010000 1.000 1.140 

1400269000 14 Pecan 0.010000 1.000 1.140 

1400278000 14 Pine nut 0.010000 1.000 1.140 

1400282000 14 Pistachio 0.010000 1.000 1.140 

1400391000 14 Walnut 0.010000 1.000 1.140 

1500025000 15 Barley, pearled barley 0.010000 1.000 1.140 

1500025001 15 Barley, pearled barley-babyfood 0.010000 1.000 1.140 

1500026000 15 Barley, flour 0.010000 1.000 1.140 

1500026001 15 Barley, flour-babyfood 0.010000 1.000 1.140 

1500027000 15 Barley, bran 0.010000 1.000 1.140 

1500065000 15 Buckwheat 0.010000 1.000 1.140 

1500066000 15 Buckwheat, flour 0.010000 1.000 1.140 

1500120000 15 Corn, field, flour 0.010000 1.000 1.140 

1500120001 15 Corn, field, flour-babyfood 0.010000 1.000 1.140 

1500121000 15 Corn, field, meal 0.010000 1.000 1.140 

1500121001 15 Corn, field, meal-babyfood 0.010000 1.000 1.140 

1500122000 15 Corn, field, bran 0.010000 1.000 1.140 

1500123000 15 Corn, field, starch 0.010000 1.000 1.140 

1500123001 15 Corn, field, starch-babyfood 0.010000 1.000 1.140 

1500124000 15 Corn, field, syrup 0.010000 1.000 1.140 

1500124001 15 Corn, field, syrup-babyfood 0.010000 1.000 1.140 

1500125000 15 Corn, field, oil 0.010000 1.000 1.140 

1500125001 15 Corn, field, oil-babyfood 0.010000 1.000 1.140 

1500126000 15 Corn, pop 0.010000 1.000 1.140 

1500127000 15 Corn, sweet 0.010000 1.000 1.140 

1500127001 15 Corn, sweet-babyfood 0.010000 1.000 1.140 

1500226000 15 Millet, grain 0.010000 1.000 1.140 

1500231000 15 Oat, bran 0.010000 1.000 1.140 

1500232000 15 Oat, flour 0.010000 1.000 1.140 

1500232001 15 Oat, flour-babyfood 0.010000 1.000 1.140 

1500233000 15 Oat, groats/rolled oats 0.010000 1.000 1.140 

1500233001 15 Oat, groats/rolled oats-babyfood 0.010000 1.000 1.140 

1500323000 15 Rice, white 9.000000 1.000 1.070 

1500323001 15 Rice, white-babyfood 9.000000 1.000 1.070 

1500324000 15 Rice, brown 9.000000 1.000 1.070 

1500324001 15 Rice, brown-babyfood 9.000000 1.000 1.070 

1500325000 15 Rice, flour 9.000000 1.000 1.070 

1500325001 15 Rice, flour-babyfood 9.000000 1.000 1.070 

1500326000 15 Rice, bran 9.000000 1.000 1.070 

1500326001 15 Rice, bran-babyfood 9.000000 1.000 1.070 

1500328000 15 Rye, grain 0.010000 1.000 1.140 

1500329000 15 Rye, flour 0.010000 1.000 1.140 

1500344000 15 Sorghum, grain 0.010000 1.000 1.140 

1500345000 15 Sorghum, syrup 0.010000 1.000 1.140 

1500381000 15 Triticale, flour 0.010000 1.000 1.140 

1500381001 15 Triticale, flour-babyfood 0.010000 1.000 1.140 

1500401000 15 Wheat, grain 0.010000 1.000 1.140 

1500401001 15 Wheat, grain-babyfood 0.010000 1.000 1.140 

1500402000 15 Wheat, flour 0.010000 1.000 1.140 

1500402001 15 Wheat, flour-babyfood 0.010000 1.000 1.140 

1500403000 15 Wheat, germ 0.010000 1.000 1.140 

1500404000 15 Wheat, bran 0.010000 1.000 1.140 

1500405000 15 Wild rice 0.010000 1.000 1.140 

1800002000 18 Alfalfa, seed 0.010000 1.000 1.140 

1901028000 19A Basil, fresh leaves 0.010000 1.000 1.140 

1901028001 19A Basil, fresh leaves-babyfood 0.010000 1.000 1.140 

1901029000 19A Basil, dried leaves 0.010000 1.000 1.140 

1901029001 19A Basil, dried leaves-babyfood 0.010000 1.000 1.140 

1901102500 19A Chive, dried leaves 0.010000 1.000 1.140 

1901118000 19A Cilantro, leaves 0.010000 1.000 1.140 

1901118001 19A Cilantro, leaves-babyfood 0.010000 1.000 1.140 

1901144000 19A Dillweed 0.010000 1.000 1.140 

1901184000 19A Herbs, other 0.010000 1.000 1.140 

1901184001 19A Herbs, other-babyfood 0.010000 1.000 1.140 

1901202000 19A Lemongrass 0.010000 1.000 1.140 

1901220000 19A Marjoram 0.010000 1.000 1.140 

1901220001 19A Marjoram-babyfood 0.010000 1.000 1.140 

1901249000 19A Parsley, dried leaves 0.010000 1.000 1.140 

1901249001 19A Parsley, dried leaves-babyfood 0.010000 1.000 1.140 

1901334000 19A Savory 0.010000 1.000 1.140 

1902105000 19B Cinnamon 0.010000 1.000 1.140 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 22 of 25 

1902105001 19B Cinnamon-babyfood 0.010000 1.000 1.140 

1902119000 19B Coriander, seed 0.010000 1.000 1.140 

1902119001 19B Coriander, seed-babyfood 0.010000 1.000 1.140 

1902143000 19B Dill, seed 0.010000 1.000 1.140 

1902274000 19B Pepper, black and white 0.010000 1.000 1.140 

1902274001 19B Pepper, black and white-babyfood 0.010000 1.000 1.140 

1902354000 19B Spices, other 0.010000 1.000 1.140 

1902354001 19B Spices, other-babyfood 0.010000 1.000 1.140 

2001163000 20A Flax seed, oil 0.010000 1.000 1.140 

2001319000 20A Rapeseed, oil 0.010000 1.000 1.140 

2001319001 20A Rapeseed, oil-babyfood 0.010000 1.000 1.140 

2001336000 20A Sesame, seed 0.010000 1.000 1.140 

2001336001 20A Sesame, seed-babyfood 0.010000 1.000 1.140 

2001337000 20A Sesame, oil 0.010000 1.000 1.140 

2001337001 20A Sesame, oil-babyfood 0.010000 1.000 1.140 

2002330000 20B Safflower, oil 0.010000 1.000 1.140 

2002330001 20B Safflower, oil-babyfood 0.010000 1.000 1.140 

2002364000 20B Sunflower, seed 0.010000 1.000 1.140 

2002365000 20B Sunflower, oil 0.010000 1.000 1.140 

2002365001 20B Sunflower, oil-babyfood 0.010000 1.000 1.140 

2003114001 20C Coconut, oil-babyfood 0.010000 1.000 1.140 

2003128000 20C Cottonseed, oil 0.400000 1.000 1.070 

2003128001 20C Cottonseed, oil-babyfood 0.400000 1.000 1.070 

2100228000 21 Mushroom 0.010000 1.000 1.140 

3100044000 31 Beef, meat 0.050000 1.000 1.210 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.210 

3100045000 31 Beef, meat, dried 0.050000 1.920 1.210 

3100046000 31 Beef, meat byproducts 0.050000 1.000 1.280 

3100046001 31 Beef, meat byproducts-babyfood 0.050000 1.000 1.280 

3100047000 31 Beef, fat 0.050000 1.000 1.100 

3100047001 31 Beef, fat-babyfood 0.050000 1.000 1.100 

3100048000 31 Beef, kidney 0.050000 1.000 1.280 

3100049000 31 Beef, liver 0.050000 1.000 1.280 

3100049001 31 Beef, liver-babyfood 0.050000 1.000 1.280 

3200169000 32 Goat, meat 0.050000 1.000 1.210 

3200170000 32 Goat, meat byproducts 0.050000 1.000 1.280 

3200171000 32 Goat, fat 0.050000 1.000 1.100 

3200172000 32 Goat, kidney 0.050000 1.000 1.280 

3200173000 32 Goat, liver 0.050000 1.000 1.280 

3300189000 33 Horse, meat 0.050000 1.000 1.210 

3400290000 34 Pork, meat 0.050000 1.000 1.210 

3400290001 34 Pork, meat-babyfood 0.050000 1.000 1.210 

3400291000 34 Pork, skin 0.050000 1.000 1.280 

3400292000 34 Pork, meat byproducts 0.050000 1.000 1.280 

3400292001 34 Pork, meat byproducts-babyfood 0.050000 1.000 1.280 

3400293000 34 Pork, fat 0.050000 1.000 1.100 

3400293001 34 Pork, fat-babyfood 0.050000 1.000 1.100 

3400294000 34 Pork, kidney 0.050000 1.000 1.280 

3400295000 34 Pork, liver 0.050000 1.000 1.280 

3500339000 35 Sheep, meat 0.050000 1.000 1.210 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.210 

3500340000 35 Sheep, meat byproducts 0.050000 1.000 1.280 

3500341000 35 Sheep, fat 0.050000 1.000 1.100 

3500341001 35 Sheep, fat-babyfood 0.050000 1.000 1.100 

3500342000 35 Sheep, kidney 0.050000 1.000 1.280 

3500343000 35 Sheep, liver 0.050000 1.000 1.280 

3600222000 36 Milk, fat 0.050000 1.000 1.160 

3600222001 36 Milk, fat-baby food/infant formu 0.050000 1.000 1.160 

3600223000 36 Milk, nonfat solids 0.050000 1.000 1.160 

3600223001 36 Milk, nonfat solids-baby food/in 0.050000 1.000 1.160 

3600224000 36 Milk, water 0.050000 1.000 1.160 

3600224001 36 Milk, water-babyfood/infant form 0.050000 1.000 1.160 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.160 

3800221000 38 Meat, game 0.010000 1.000 1.140 

3900312000 39 Rabbit, meat 0.010000 1.000 1.140 

4000093000 40 Chicken, meat 0.010000 1.000 1.140 

4000093001 40 Chicken, meat-babyfood 0.010000 1.000 1.140 

4000094000 40 Chicken, liver 0.010000 1.000 1.060 

4000095000 40 Chicken, meat byproducts 0.010000 1.000 1.060 

4000095001 40 Chicken, meat byproducts-babyfoo 0.010000 1.000 1.060 

4000096000 40 Chicken, fat 0.010000 1.000 1.140 

4000096001 40 Chicken, fat-babyfood 0.010000 1.000 1.140 

4000097000 40 Chicken, skin 0.010000 1.000 1.060 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 23 of 25 

4000097001 40 Chicken, skin-babyfood 0.010000 1.000 1.060 

5000382000 50 Turkey, meat 0.010000 1.000 1.140 

5000382001 50 Turkey, meat-babyfood 0.010000 1.000 1.140 

5000383000 50 Turkey, liver 0.010000 1.000 1.060 

5000383001 50 Turkey, liver-babyfood 0.010000 1.000 1.060 

5000384000 50 Turkey, meat byproducts 0.010000 1.000 1.060 

5000384001 50 Turkey, meat byproducts-babyfood 0.010000 1.000 1.060 

5000385000 50 Turkey, fat 0.010000 1.000 1.140 

5000385001 50 Turkey, fat-babyfood 0.010000 1.000 1.140 

5000386000 50 Turkey, skin 0.010000 1.000 1.060 

5000386001 50 Turkey, skin-babyfood 0.010000 1.000 1.060 

6000301000 60 Poultry, other, meat 0.010000 1.000 1.140 

6000302000 60 Poultry, other, liver 0.010000 1.000 1.060 

6000303000 60 Poultry, other, meat byproducts 0.010000 1.000 1.060 

6000304000 60 Poultry, other, fat 0.010000 1.000 1.140 

6000305000 60 Poultry, other, skin 0.010000 1.000 1.060 

7000145000 70 Egg, whole 0.010000 1.000 1.100 

7000145001 70 Egg, whole-babyfood 0.010000 1.000 1.100 

7000146000 70 Egg, white 0.010000 1.000 1.100 

7000146001 70 Egg, white (solids)-babyfood 0.010000 1.000 1.100 

7000147000 70 Egg, yolk 0.010000 1.000 1.100 

7000147001 70 Egg, yolk-babyfood 0.010000 1.000 1.100 

8000157000 80 Fish-freshwater finfish 0.010000 1.000 1.140 

8000158000 80 Fish-freshwater finfish, farm ra 0.010000 1.000 1.140 

8000159000 80 Fish-saltwater finfish, tuna 0.010000 1.000 1.140 

8000160000 80 Fish-saltwater finfish, other 0.010000 1.000 1.140 

8000161000 80 Fish-shellfish, crustacean 0.010000 1.000 1.140 

8000162000 80 Fish-shellfish, mollusc 0.010000 1.000 1.140 

8601000000 86A Water, direct, all sources 0.257000 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.257000 1.000 1.000 

9500000500 O Acai berry 0.010000 1.000 1.140 

9500001000 O Acerola 0.010000 1.000 1.140 

9500001500 O Agave 0.010000 1.000 1.140 

9500006000 O Amaranth, grain 0.010000 1.000 1.140 

9500016000 O Artichoke, globe 0.010000 1.000 1.140 

9500019000 O Asparagus 0.010000 1.000 1.140 

9500019500 O Atemoya 0.010000 1.000 1.140 

9500020000 O Avocado 0.010000 1.000 1.140 

9500022000 O Bamboo, shoots 0.010000 1.000 1.140 

9500023000 O Banana 0.010000 1.000 1.140 

9500023001 O Banana-babyfood 0.010000 1.000 1.140 

9500024000 O Banana, dried 0.010000 1.000 1.140 

9500024001 O Banana, dried-babyfood 0.010000 1.000 1.140 

9500054000 O Belgium endive 0.010000 1.000 1.140 

9500060000 O Breadfruit 0.010000 1.000 1.140 

9500073000 O Cactus 0.010000 1.000 1.140 

9500074000 O Canistel 0.010000 1.000 1.140 

9500077000 O Carob 0.010000 1.000 1.140 

9500089000 O Cherimoya 0.010000 1.000 1.140 

9500109000 O Cocoa bean, chocolate 0.010000 1.000 1.140 

9500110000 O Cocoa bean, powder 0.010000 1.000 1.140 

9500111000 O Coconut, meat 0.010000 1.000 1.140 

9500111001 O Coconut, meat-babyfood 0.010000 1.000 1.140 

9500112000 O Coconut, dried 0.010000 1.000 1.140 

9500113000 O Coconut, milk 0.010000 1.000 1.140 

9500114000 O Coconut, oil 0.010000 1.000 1.140 

9500115000 O Coffee, roasted bean 0.010000 1.000 1.140 

9500116000 O Coffee, instant 0.010000 1.000 1.140 

9500141000 O Date 0.010000 1.000 1.140 

9500151000 O Feijoa 0.010000 1.000 1.140 

9500153000 O Fig 0.010000 1.000 1.140 

9500154000 O Fig, dried 0.010000 1.000 1.140 

9500177000 O Grape, leaves 0.900000 1.000 1.140 

9500178000 O Grape, raisin 2.500000 1.000 1.140 

9500183000 O Guava 0.010000 1.000 1.140 

9500183001 O Guava-babyfood 0.010000 1.000 1.140 

9500186000 O Honey 0.010000 1.000 1.140 

9500186001 O Honey-babyfood 0.010000 1.000 1.140 

9500188000 O Hop 0.010000 1.000 1.140 

9500193000 O Jackfruit 0.010000 1.000 1.140 

9500209000 O Longan 0.010000 1.000 1.140 

9500211000 O Lychee 0.010000 1.000 1.140 

9500212000 O Lychee, dried 0.010000 1.000 1.140 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 24 of 25 

9500214000 O Mamey apple 0.010000 1.000 1.140 

9500215000 O Mango 0.010000 1.000 1.140 

9500215001 O Mango-babyfood 0.010000 1.000 1.140 

9500216000 O Mango, dried 0.010000 1.000 1.140 

9500217000 O Mango, juice 0.010000 1.000 1.140 

9500217001 O Mango, juice-babyfood 0.010000 1.000 1.140 

9500218000 O Maple, sugar 0.010000 1.000 1.140 

9500219000 O Maple syrup 0.010000 1.000 1.140 

9500235000 O Olive 0.010000 1.000 1.140 

9500236000 O Olive, oil 0.010000 1.000 1.140 

9500243000 O Palm heart, leaves 0.010000 1.000 1.140 

9500244000 O Palm, oil 0.010000 1.000 1.140 

9500244001 O Palm, oil-babyfood 0.010000 1.000 1.140 

9500245000 O Papaya 0.010000 1.000 1.140 

9500245001 O Papaya-babyfood 0.010000 1.000 1.140 

9500246000 O Papaya, dried 0.010000 1.000 1.140 

9500247000 O Papaya, juice 0.010000 1.000 1.140 

9500252000 O Passionfruit 0.010000 1.000 1.140 

9500252001 O Passionfruit-babyfood 0.010000 1.000 1.140 

9500253000 O Passionfruit, juice 0.010000 1.000 1.140 

9500253001 O Passionfruit, juice-babyfood 0.010000 1.000 1.140 

9500254000 O Pawpaw 0.010000 1.000 1.140 

9500263000 O Peanut 0.010000 1.000 1.140 

9500264000 O Peanut, butter 0.010000 1.000 1.140 

9500265000 O Peanut, oil 0.010000 1.000 1.140 

9500275000 O Peppermint 0.010000 1.000 1.140 

9500276000 O Peppermint, oil 0.010000 1.000 1.140 

9500277000 O Persimmon 0.010000 1.000 1.140 

9500279000 O Pineapple 0.010000 1.000 1.140 

9500279001 O Pineapple-babyfood 0.010000 1.000 1.140 

9500280000 O Pineapple, dried 0.010000 1.000 1.140 

9500281000 O Pineapple, juice 0.010000 1.000 1.140 

9500281001 O Pineapple, juice-babyfood 0.010000 1.000 1.140 

9500283000 O Plantain 0.010000 1.000 1.140 

9500284000 O Plantain, dried 0.010000 1.000 1.140 

9500289000 O Pomegranate 0.010000 1.000 1.140 

9500306000 O Psyllium, seed 0.010000 1.000 1.140 

9500311000 O Quinoa, grain 0.010000 1.000 1.140 

9500333000 O Sapote, Mamey 0.010000 1.000 1.140 

9500335000 O Seaweed 0.010000 1.000 1.140 

9500335001 O Seaweed-babyfood 0.010000 1.000 1.140 

9500346000 O Soursop 0.010000 1.000 1.140 

9500351000 O Spanish lime 0.010000 1.000 1.140 

9500352000 O Spearmint 0.010000 1.000 1.140 

9500353000 O Spearmint, oil 0.010000 1.000 1.140 

9500358000 O Starfruit 0.010000 1.000 1.140 

9500361000 O Sugar apple 0.010000 1.000 1.140 

9500362000 O Sugarcane, sugar 0.010000 1.000 1.140 

9500362001 O Sugarcane, sugar-babyfood 0.010000 1.000 1.140 

9500363000 O Sugarcane, molasses 0.010000 1.000 1.140 

9500363001 O Sugarcane, molasses-babyfood 0.010000 1.000 1.140 

9500368000 O Tamarind 0.010000 1.000 1.140 

9500372000 O Tea, dried 50.000000 1.000 1.140 

9500373000 O Tea, instant 50.000000 1.000 1.140 

9500373500 O Teff, flour 0.010000 1.000 1.140 

9500390000 O Vinegar 0.010000 1.000 1.140 

9500397000 O Water chestnut 0.010000 1.000 1.140 

9500398000 O Watercress 8.000000 1.000 1.140 
Dinotefuran Dietary Exposure and Risk Assessment DP Number: D410585 

PC Code: 044312 

______________________________________________________________________________________

Page 25 of 25 

Attachment 4: Chronic Results File 

U.S. EPA Ver. 3.16, 03-08-d 

DEEM-FCID Chronic analysis for DINOTEFURAN NHANES 2003-2008 2-day 

Residue file name: C:\Documents and Settings\NDODD\My Documents\DEEM Version 

3.16\Dinotefuran 2013\Dinotefuran chronic 042513.R08 

 Adjustment factor #2 used. 

Analysis Date 04-25-2013/10:17:01 Residue file dated: 04-25-2013/10:15:24 

Reference dose (RfD, Chronic) = 1 mg/kg bw/day 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------- 

Total US Population 0.016633 1.7% 

Hispanic 0.018804 1.9% 

Non-Hisp-White 0.015699 1.6% 

Non-Hisp-Black 0.016193 1.6% 

Non-Hisp-Other 0.024558 2.5% 

Nursing Infants 0.026119 2.6% 

Non-Nursing Infants 0.057302 5.7% 

Female 13+ PREG 0.014557 1.5% 

Children 1-6 0.042497 4.2% 

Children 7-12 0.017390 1.7% 

Male 13-19 0.010793 1.1% 

Female 13-19/NP 0.011705 1.2% 

Male 20+ 0.013543 1.4% 

Female 20+/NP 0.013844 1.4% 

Seniors 55+ 0.013157 1.3% 

All Infants 0.047675 4.8% 

Female 13-50 0.013418 1.3% 

Children 1-2 0.056650 5.7% 

Children 3-5 0.037044 3.7% 

Children 6-12 0.018991 1.9% 

Youth 13-19 0.011261 1.1% 

Adults 20-49 0.013944 1.4% 

Adults 50-99 0.013404 1.3% 

Female 13-49 0.013432 1.3% 

-------------------------------------------------------------------------------