<PAGE>

                                                                     EXHIBIT 2.6





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                AGREEMENT AND PLAN OF MERGER AND REORGANIZATION


                                    among:


                              DNA Sciences, Inc.,
                            a Delaware corporation;


                            PIPO Acquisition Corp.,
                            a Delaware corporation;


                                      and


                                  PPGx, Inc.,
                            a Delaware corporation;


                       _________________________________

                         Dated as of December 17, 2000
                       _________________________________


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                               Table Of Contents
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SECTION 1. Description of Transaction.................................................   1

    1.1   Merger of Merger Sub into the Company.......................................   1

    1.2   Effect of the Merger........................................................   1

    1.3   Closing; Effective Time.....................................................   1

    1.4   Certificate of Incorporation and Bylaws; Directors and Officers.............   2

    1.5   Conversion of Shares........................................................   2

    1.6   Stock Options...............................................................   6

    1.7   Closing of the Company's Transfer Books.....................................   7

    1.8   Exchange of Certificates; Escrow Shares.....................................   7

    1.9   Appraisal Rights............................................................   9

   1.10   Tax Consequences............................................................  10

   1.11   Accounting Treatment........................................................  10

   1.12   Further Action..............................................................  10

SECTION 2. Representations and Warranties of the Company..............................  10

    2.1   Due Organization; Subsidiaries; Etc.........................................  10

    2.2   Certificate of Incorporation and Bylaws; Records............................  11

    2.3   Capitalization, Etc.........................................................  11

    2.4   Financial Statements........................................................  13

    2.5   Absence of Changes..........................................................  13

    2.6   Title to Assets.............................................................  15

    2.7   Bank Accounts; Receivables..................................................  15

    2.8   Equipment; Leasehold........................................................  16

    2.9   Proprietary Assets..........................................................  16

   2.10   Contracts...................................................................  19

   2.11   Liabilities.................................................................  22

   2.12   Compliance with Legal Requirements..........................................  22

   2.13   Governmental Authorizations and Facility Certifications.....................  22

   2.14   Tax Matters.................................................................  23

   2.15   Employee and Labor Matters; Benefit Plans...................................  25

   2.16   Environmental Matters.......................................................  27
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  2.17  Insurance.........................................................  28

  2.18  Related Party Transactions........................................  28

  2.19  Legal Proceedings; Orders.........................................  28

  2.20  Authority; Binding Nature of Agreement............................  29

  2.21  Non-Contravention; Consents.......................................  29

  2.22  Inapplicability of Section 2115 of California Corporations Code...  30

  2.23  Vote Required.....................................................  30

  2.24  Brokers or Finders................................................  30

  2.25  Full Disclosure...................................................  30

SECTION 3. Representations and Warranties of Parent and Merger Sub........  31

  3.1   Organization and Standing; Articles and Bylaws....................  31

  3.2   Capitalization....................................................  31

  3.3   Financial Statements..............................................  32

  3.4   Actions...........................................................  32

  3.5   Title to Properties and Assets; Liens, etc........................  32

  3.6   Patents, Trademarks, etc..........................................  33

  3.7   Proprietary Information and Inventions Agreements.................  33

  3.8   Material Contracts and Commitments................................  33

  3.9   Compliance with Other Instruments.................................  33

  3.10  Validity of Parent Capital Stock..................................  34

  3.11  Governmental Authorizations.......................................  34

  3.12  Tax Returns and Payments..........................................  34

  3.13  Tax Elections.....................................................  34

  3.14  Employees.........................................................  35

  3.15  Employee Benefit Plans............................................  35

  3.16  Environmental Matters.............................................  35

  3.17  Insurance.........................................................  35

  3.18  No Conflict of Interest...........................................  35

  3.19  Litigation, etc...................................................  36

  3.20  Authority; Binding Nature of Agreement............................  36
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    3.21  Non-Contravention; Consents................................................................... 36

    3.22  Financial Condition........................................................................... 36

    3.24  U.S. Real Property Holding Corporation........................................................ 37

    3.25  Investment Company Act........................................................................ 37

    3.26  No Brokers or Finders......................................................................... 37

    3.27  Full Disclosure............................................................................... 37

SECTION 4. Certain Covenants of the Parties............................................................. 37

     4.1  Access and Investigation...................................................................... 37

     4.2  Operation of the Company's Business........................................................... 37

     4.3  Notification; Updates to Company Disclosure Schedule.......................................... 40

     4.4  Notification; Updates to Parent Disclosure Schedule........................................... 41

     4.5  Operation of Parent's Business.  During the Pre-Closing Period:............................... 41

     4.6  No Negotiation................................................................................ 42

SECTION 5. Additional Covenants of the Parties.......................................................... 43

     5.1  Filings and Consents.......................................................................... 43

     5.2  Company Stockholders' Meeting................................................................. 43

     5.3  Public Announcements.......................................................................... 44

     5.4  Reasonable Efforts............................................................................ 44

     5.5  Tax Matters................................................................................... 44

     5.6  Noncompetition Agreements..................................................................... 44

     5.7  Employment Agreements......................................................................... 44

     5.8  Releases...................................................................................... 45

     5.9  Underwriter Lockup Agreements................................................................. 45

    5.10  Amendment/Clarification of Existing Agreements; Payoff of Company Line of Credit.............. 45

    5.11  Termination of Certain Agreements............................................................. 45

    5.12  FIRPTA Matters................................................................................ 45

    5.13  Employee and Related Matters.................................................................. 46

SECTION 6. Conditions Precedent to Obligations of Parent and Merger Sub................................. 46

    6.1   Accuracy of Representations................................................................... 46
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     6.2      Performance of Covenants............................................................   47

     6.3      Stockholder Approval................................................................   47

     6.4      Consents............................................................................   47

     6.5      Agreements and Documents............................................................   47

     6.6      Absence of Material Adverse Effect..................................................   48

     6.7      HSR Act.............................................................................   48

     6.8      FIRPTA Compliance...................................................................   48

     6.9      No Restraints.......................................................................   48

     6.10     No Legal Proceedings................................................................   48

     6.11     Employees...........................................................................   48

     6.12     Termination of Certain Agreements...................................................   49

     6.13     Closing of Series C Investment......................................................   49

     6.15     Company Amended and Restated Certificate............................................   49

SECTION 7. Conditions Precedent to Obligations of the Company.....................................   49

     7.1      Accuracy of Representations.........................................................   49

     7.2      Performance of Covenants............................................................   49

     7.3      Documents...........................................................................   49

     7.4      No Restraints.......................................................................   50

     7.5      Absence of Material Adverse Effect..................................................   50

     7.6      HSR Act.............................................................................   50

     7.7      Amended and Restated Certificate....................................................   50

     7.8      Director Appointment................................................................   50

     7.9      Company Amended and Restated Certificate............................................   50

     7.10     Closing of Series C Investment......................................................   50

SECTION 8. Termination............................................................................   50

     8.1      Termination Events..................................................................   50

     8.2      Termination Procedures..............................................................   51

     8.3      Effect of Termination...............................................................   51

SECTION 9. Indemnification, Etc...................................................................   51

     9.1      Survival of Representations, Etc....................................................   51

     9.2      Indemnification.....................................................................   52
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     9.3       Deductible...................................................................  53

     9.4       Exclusive Remedy for Monetary Damages........................................  54

     9.5       No Contribution..............................................................  54

     9.6       Interest.....................................................................  54

     9.7       Defense of Third Party Claims................................................  54

     9.8       Exercise of Remedies by Parent Indemnitees Other Than Parent.................  55

SECTION 10. Miscellaneous Provisions........................................................  55

    10.1       Stockholders' Agents.........................................................  55

    10.2       Further Assurances...........................................................  55

    10.3       Fees and Expenses............................................................  55

    10.4       Attorneys' Fees..............................................................  56

    10.5       Notices......................................................................  56

    10.6       Confidentiality..............................................................  57

    10.7       Time of the Essence..........................................................  57

    10.8       Headings.....................................................................  57

    10.9       Counterparts.................................................................  57

    10.10      Governing Law................................................................  57

    10.11      Successors and Assigns.......................................................  57

    10.12      Remedies Cumulative; Specific Performance....................................  58

    10.13      Waiver.......................................................................  58

    10.14      Amendments...................................................................  58

    10.15      Severability.................................................................  58

    10.16      Parties in Interest..........................................................  58

    10.17      Entire Agreement.............................................................  58

    10.18      Construction.................................................................  59
</TABLE>

                                      v.
<PAGE>

                              AGREEMENT AND PLAN
                         OF MERGER AND REORGANIZATION

     THIS AGREEMENT AND PLAN OF MERGER AND REORGANIZATION ("Agreement") is made
and entered into as of December 17, 2000, by and among: DNA SCIENCES, INC., a
Delaware corporation ("Parent"), PIPO ACQUISITION CORP., a Delaware corporation
and a wholly owned subsidiary of Parent ("Merger Sub"), and PPGX, INC., a
Delaware corporation (the "Company"). Certain capitalized terms used in this
Agreement are defined in Exhibit A.

                                   Recitals

     A.   Parent, Merger Sub and the Company intend to effect a merger of
Merger Sub into the Company in accordance with this Agreement and the Delaware
General Corporation Law (the "Merger"). Upon consummation of the Merger, Merger
Sub will cease to exist, and the Company will become a wholly owned subsidiary
of Parent.

     B.   It is intended that the Merger qualify as a tax-free reorganization
within the meaning of Section 368(a) of the Internal Revenue Code of 1986, as
amended (the "Code"). For accounting purposes, it is intended that the Merger be
treated as a "purchase."

     C.   This Agreement has been approved by the respective boards of directors
of Parent, Merger Sub and the Company.

     D.   Contemporaneously with the execution and delivery of this Agreement,
each of Axys Pharmaceuticals, Inc. ("Axys") and Pharmaceutical Product
Development, Inc. ("PPD," and collectively with Axys, the "Major Stockholders")
is executing and delivering to Parent a voting agreement (a "Voting Agreement")
of even date herewith substantially in the form of Exhibit B.


                                   Agreement

     The parties to this Agreement agree as follows:

SECTION 1. Description of Transaction

     1.1  Merger of Merger Sub into the Company. Upon the terms and subject to
the conditions set forth in this Agreement, at the Effective Time (as defined in
Section 1.3), Merger Sub shall be merged with and into the Company, and the
separate existence of Merger Sub shall cease. The Company will continue as the
surviving corporation in the Merger (the "Surviving Corporation").

     1.2  Effect of the Merger. The Merger shall have the effects set forth in
this Agreement and in the applicable provisions of the Delaware General
Corporation Law.

     1.3  Closing; Effective Time. The consummation of the transactions
contemplated by this Agreement (the "Closing") shall take place at the offices
of Cooley Godward LLP, 3000 El Camino Real, Five Palo Alto Square, Palo Alto,
California 94306 at 10:00 a.m. on a date to be mutually agreed upon by Parent
and the Company no later than three days after the satisfaction

                                      1.
<PAGE>

(or, to the extent permitted, the waiver) of the conditions set forth in
Sections 6 and 7. Contemporaneously with or as promptly as practicable after the
Closing, a properly executed certificate of merger conforming to the
requirements of the Delaware General Corporation Law shall be filed with the
Secretary of State of the State of Delaware. The Merger shall become effective
at the time such certificate of merger is filed with the Secretary of State of
the State of Delaware (the "Effective Time").

     1.4  Certificate of Incorporation and Bylaws; Directors and Officers.
Unless otherwise determined by Parent and the Company prior to the Effective
Time:

          (a)  the certificate of incorporation of the Surviving Corporation
     shall be amended and restated as of the Effective Time in a form acceptable
     to Parent;

          (b)  the bylaws of the Surviving Corporation shall be amended and
     restated as of the Effective Time to conform to the bylaws of Merger Sub as
     in effect immediately prior to the Effective Time; and

          (c)  the directors and officers of the Surviving Corporation
     immediately after the Effective Time shall be the individuals selected by
     Parent prior to the Closing.

     1.5  Conversion of Shares.

          (a)  Subject to Sections 1.8(c) and 1.9, at the Effective Time, by
virtue of the Merger and without any further action on the part of Parent,
Merger Sub, the Company or any stockholder of the Company:

               (i)   each share of common stock of the Company (par value $0.001
     per share) ("Company Common Stock") outstanding immediately prior to the
     Effective Time shall be converted into the right to receive a fraction of a
     share of the common stock (par value $0.001 per share) of Parent ("Parent
     Common Stock") equal to the Remainder Exchange Ratio;

               (ii)  each share of Series A preferred stock of the Company (par
     value $0.001 per share) ("Company Series A Preferred Stock") outstanding
     immediately prior to the Effective Time shall be converted into the right
     to receive a fraction of a share of the Series D preferred stock (par value
     $0.001 per share) of Parent ("Parent Series D Preferred Stock," and
     together with Parent Common Stock, "Parent Capital Stock") equal to the
     Series A Exchange Ratio; and

               (iii) each share of the common stock (par value $0.001 per share)
     of Merger Sub outstanding immediately prior to the Effective Time shall be
     converted into one share of common stock of the Surviving Corporation.

          (b)  For purposes of this Agreement:

               (i)    The "Series A Exchange Ratio" shall be equal to (A) the
     Liquidation Portion Exchange Ratio plus (B) the Remainder Exchange Ratio,
     rounded to five decimal places.

                                      2.
<PAGE>

               (ii)   The "Liquidation Consideration" shall be equal to (A) the
     Debt Repayment divided by (B) a fraction, the numerator of which is
     $47,000,000, and the denominator of which is the Merger Consideration,
     rounded to five decimal places.

               (iii)  The "Liquidation Portion Exchange Ratio" is equal to (A)
     the Liquidation Consideration divided by (B) 10,000,000, rounded to five
     decimal places.

               (iv)   The "Remainder Exchange Ratio" shall be equal to (A) the
     Merger Consideration minus the Liquidation Consideration divided by (B) the
     Aggregate Company Common Number, rounded to five decimal places.

               (v)    The "Debt Repayment" shall mean (A) the actual outstanding
     indebtedness due and payable to the Bank (as defined in Section 4.2(k))
     that is actually repaid by the Company on or prior to the Closing Date in
     accordance with Section 5.10(c) and (B) the value of the indebtedness due
     and payable to the Major Stockholders under the Loan Agreement (as defined
     in Section 4.2(n)) that is actually contributed to capital of the Company
     by the Major Stockholders on or prior to the Closing Date in accordance
     with Section 5.10(c).

               (vi)   "Merger Consideration" shall be equal to (A) 0.1175 times
     (B) the Aggregate Parent Common Number.

               (vii)  The "Aggregate Parent Common Number" shall mean the sum of
     (1) the total number of shares of Parent Common Stock that are issued and
     outstanding on the date hereof; (2) the total number of shares of Parent
     Common Stock that are issuable upon the conversion of any shares of Parent
     Preferred Stock issued and outstanding on the date hereof; (3) the total
     number of shares of Parent Common Stock that are issuable upon the
     conversion of any shares of Parent Series C Preferred Stock issued to PPD
     in connection with the closing of the Series C Investment (as defined in
     Section 6.14) and issued or to be issued to Alliance Capital Partners; (4)
     the total number of shares of Parent Common Stock that are issuable upon
     the exercise in full of all warrants to acquire shares of Parent Common
     Stock that are outstanding on the date hereof; (5) the total number of
     shares of Parent Common Stock that are issuable upon conversion of any
     shares of Parent Preferred Stock that are issuable upon the exercise in
     full of all warrants to acquire shares of Parent Preferred Stock that are
     outstanding on the date hereof; (6) the total number of shares of Down
     Round Stock that are issued and outstanding immediately prior to the
     Effective Time or pursuant to a contractual agreement under which Parent is
     bound, as of the Effective Time, to issue Down Round Stock subsequent to
     the Effective Time; and (7) the total number of shares of capital stock of
     Parent that are issuable upon the conversion or exercise in full of all
     convertible securities or options (whether vested or unvested), warrants or
     other rights to acquire capital stock of Parent that are outstanding on the
     Initial Series C Closing Date other than convertible securities or warrants
     referred to in clauses "(2)," "(3)," "(4)," "(5)" or "(6)" of this
     sentence; provided, however, that notwithstanding anything to the contrary
     contained in this paragraph, no shares, warrants, options or rights shall
     be counted more than one time in calculating the "Aggregate Parent Common
     Number."

                                      3.
<PAGE>

               (viii)  The "Aggregate Company Common Number" shall mean the sum
     of (1) the total number of shares of Company Common Stock that are issued
     and outstanding immediately prior to the Effective Time; (2) the total
     number of shares of Company Common Stock that are issuable upon the
     conversion of any shares of Company Series A Preferred Stock issued and
     outstanding immediately prior to the Effective Time; and (3) the total
     number of shares of Company Capital Stock that are issuable upon the
     conversion or exercise in full of all convertible securities or options,
     warrants or other rights to acquire capital stock of the Company that are
     outstanding immediately prior to the Effective Time other than convertible
     securities or warrants referred to in clause "(2)" of this sentence;
     provided, however, that notwithstanding anything to the contrary contained
     in this paragraph, no shares, warrants, options or rights shall be counted
     more than one time in calculating the "Aggregate Company Common Number."

               (ix)    "Down Round Stock" shall mean all shares of Parent Common
     Stock issued or deemed to be issued by Parent pursuant to this Section
     1.5(b)(v) in a Subsequent Equity Financing (as defined in Section
     1.5(b)(ix)) after the date hereof for an Effective Price less than $14.27
     other than (A) shares of Parent Common Stock issued upon conversion of
     Parent Preferred Stock; (B) shares of Parent Common Stock issued pursuant
     to the bona fide acquisition of (i) another entity by Parent by merger,
     purchase of substantially all of the assets of such entity, or other
     reorganization, or (ii) technology, software, patents or other intellectual
     property by license or purchase; (C) up to 4,500,000 shares of Parent
     Common Stock (or related options) issued to employees, officers, directors,
     consultants, or other persons performing services for Parent (including,
     but not by way of limitation, distributors and sales representatives)
     pursuant to any stock offering, plan, or arrangement approved by Parent's
     board of directors; (D) shares of capital stock issued to financial
     institutions in connection with the extension of credit to Parent or in
     connection with the lease of equipment, up to a maximum of one percent (1%)
     of Parent Common Stock issued and outstanding immediately prior to the date
     of this Agreement, and in both cases for other than equity financing
     purposes as approved by Parent's board of directors; or (E) shares of
     capital stock issued in connection with any stock split, stock dividend or
     recapitalization by Parent. In the event Parent at any time or from time to
     time after the date of this Agreement issues any Options or Convertible
     Securities or shall fix a record date for the determination of holders of
     any class of securities entitled to receive any such Options or Convertible
     Securities, then the maximum number of shares (as set forth in the
     instrument relating thereto assuming the satisfaction of any conditions to
     exercisability, including, without limitation, the passage of time and
     without regard to any provisions contained therein for a subsequent
     adjustment of such number) of Parent Common Stock issuable upon the
     exercise of such Options or, in the case of Convertible Securities and
     Options therefor, the conversion or exchange of such Convertible
     Securities, shall be deemed to be shares of Down Round Stock issued as of
     the time of such issue or, in case such a record date shall have been
     fixed, as of the close of business on such record date, provided that with
     respect to a series of preferred stock of Parent, Down Round Stock shall
     not be deemed to have been issued unless the consideration per share of
     such Down Round Stock would be less than the conversion price of such
     series in effect on the date of and immediately prior

                                      4.
<PAGE>

     to such issue, or such record date, as the case may be, and provided
     further that in any such case in which shares of Down Round Stock are
     deemed to be issued:

          (1)       no further adjustment in the Aggregate Parent Common Number
shall be made upon the subsequent issue of Convertible Securities or shares of
Parent Common Stock upon the exercise of such Options or conversion or exchange
of such Convertible Securities;

          (2)       if such Options or Convertible Securities by their terms
provide, with the passage of time or otherwise, for any increase or decrease in
the consideration payable to Parent, or in the number of shares of Parent Common
Stock issuable, upon the exercise, conversion or exchange thereof, the Exchange
Ratio shall be computed so as to reflect any such increase or decrease that has
occurred on or prior to the Effective Time insofar as it affects such Options or
the rights of conversion or exchange under such Convertible Securities;

          (3)       in the event of the expiration or termination of any such
Options or any rights of conversion or exchange under such Convertible
Securities on or prior to the Effective Time, the Exchange Ratio shall be
computed as if:

                    a.       in the case of Convertible Securities or Options
          for Parent Common Stock, the only shares of Down Round Stock issued
          were shares of Parent Common Stock, if any, actually issued upon the
          exercise of such Options or the conversion or exchange of such
          Convertible Securities and the consideration received therefor was the
          consideration actually received by Parent for the issue of all such
          Options, whether or not exercised, plus the consideration actually
          received by Parent upon such exercise, or for the issue of all such
          Convertible Securities which were actually converted or exchanged,
          plus the additional consideration, if any, actually received by Parent
          upon such conversion or exchange, and

                    b.       in the case of Options for Convertible Securities,
          only the Convertible Securities, if any, actually issued upon the
          exercise thereof were issued at the time of issue of such Options, and
          the consideration received by Parent for the shares of Down Round
          Stock deemed to have been then issued was the consideration actually
          received by Parent for the issue of all such Options, whether or not
          exercised, plus the consideration deemed to have been received by
          Parent upon the issue of the Convertible Securities with respect to
          which such Options were actually exercised;

                    (x)      "Convertible Securities" shall mean any evidences
          of indebtedness, shares (other than Parent Common Stock) or other
          securities convertible into or exchangeable for Parent Common Stock.

                    (xi)     The "Effective Price" of a share of Down Round
          Stock shall mean the quotient obtained by dividing the total number of
          shares of Down Round Stock issued or sold, or deemed to have been
          issued or sold by Parent under Section 1.5(b)(v), into the

                                      5.
<PAGE>

         dollar value of the aggregate consideration received, or deemed to have
         been received by Parent, for such shares of Down Round Stock.

                    (xii)    "Options" shall mean rights, options or warrants to
         subscribe for, purchase or otherwise acquire either Parent Common Stock
         or Convertible Securities.

                    (xiii)   A "Subsequent Equity Financing" shall mean the sale
         by Parent, prior to the Effective Time, of Down Round Stock.

               (c)  If any shares of Company Capital Stock outstanding
immediately prior to the Effective Time are unvested or are subject to a
repurchase option, risk of forfeiture or other condition under any applicable
restricted stock purchase agreement or other agreement with the Company, then
the shares of Parent Capital Stock issued in exchange for such shares of Company
Capital Stock will also be unvested and subject to the same repurchase option,
risk of forfeiture or other condition, and the certificates representing such
shares of Parent Capital Stock may accordingly be marked with appropriate
legends.

               (d)  Fifteen percent (15%) of the shares of Parent Capital Stock
otherwise issuable in the Merger to the Major Stockholders (without taking into
account any deductions in respect of payment for Excess Transaction Expenses)
shall be delivered into escrow and held as specified in Section 1.8. In
addition, to the extent a Major Stockholder has not paid such Major
Stockholder's pro rata portion of the Excess Transaction Expenses, an additional
number of shares of Parent Series D Preferred Stock equal to the quotient
obtained by dividing (1) such Major Stockholder's pro rata portion of such
Excess Transaction Expenses by (2) $14.27 (rounded down to the nearest whole
number of shares) shall be deducted from the number of shares of Parent Series D
Preferred Stock otherwise issuable to such Major Stockholder.

               (e)  If, between the date of this Agreement and the Effective
Time, the outstanding shares of Company Capital Stock or Parent Capital Stock
are changed into a different number or class of shares by reason of any stock
split, division or subdivision of shares, stock dividend, reverse stock split,
consolidation of shares, reclassification, recapitalization or other similar
transaction, then the Exchange Ratio shall be appropriately adjusted.

          1.6  Stock Options. At the Effective Time, each option to purchase
shares of Company Capital Stock that is then outstanding, whether vested or
unvested (a "Company Option"), shall be assumed by Parent in accordance with the
terms (as in effect as of the date of this Agreement) of the Company's 1999
Equity Incentive Plan (the "Stock Plan") and the stock option agreement by which
such Company Option is evidenced. All rights with respect to Company Common
Stock under outstanding Company Options shall thereupon be converted into rights
with respect to Parent Common Stock. Accordingly, from and after the Effective
Time, (i) each Company Option assumed by Parent may be exercised solely for
shares of Parent Common Stock, (ii) the number of shares of Parent Common Stock
subject to each such assumed Company Option shall be equal to the number of
shares of Company Common Stock that were subject to such Company Option
immediately prior to the Effective Time multiplied by the Exchange Ratio,
rounded down to the nearest whole number of shares of Parent Common Stock, (iii)
the per share exercise price for the Parent Common Stock issuable upon exercise
of each such assumed Company Option shall be determined by dividing the exercise
price per share of

                                      6.
<PAGE>

Company Common Stock subject to such Company Option, as in effect immediately
prior to the Effective Time, by the Exchange Ratio, and rounding the resulting
exercise price up to the nearest whole cent and (iv) all restrictions on the
exercise of each such assumed Company Option shall continue in full force and
effect, and the term, exercisability, vesting schedule and other provisions of
such Company Option shall otherwise remain unchanged and shall continue to have,
and be subject to, the same terms and conditions as set forth in the Stock Plan
and/or stock option agreement by which such Company Option is evidenced
immediately prior to the Effective Time; provided, however, that each such
assumed Company Option shall, in accordance with its terms, be subject to
further adjustment as appropriate to reflect any stock split, reverse stock
split, stock dividend, recapitalization or other similar transaction effected by
Parent after the Effective Time. The Company and Parent shall take all action
that may be necessary to effectuate the provisions of this Section 1.6.
Following the Closing, Parent will send to each holder of an assumed Company
Option a written notice setting forth (i) the number of shares of Parent Common
Stock subject to such assumed Company Option, and (ii) the exercise price per
share of Parent Common Stock issuable upon exercise of such assumed Company
Option. Parent shall take all necessary corporate action to reserve for issuance
a sufficient number of shares of Parent Common Stock for delivery upon exercise
of Company Options assumed in accordance with this Section 1.6. Notwithstanding
anything to the contrary contained in this Section 1.6, in lieu of assuming
outstanding Company Options in accordance with this Section 1.6 Parent may, at
its election, cause such outstanding Company Options to be replaced by issuing
reasonably equivalent replacement stock options in substitution therefor.

          1.7  Closing of the Company's Transfer Books. At the Effective Time,
holders of certificates representing shares of Company Capital Stock that were
outstanding immediately prior to the Effective Time shall cease to have any
rights as stockholders of the Company, and the stock transfer books of the
Company shall be closed with respect to all shares of such capital stock
outstanding immediately prior to the Effective Time. No further transfer of any
such shares of Company Capital Stock shall be made on such stock transfer books
after the Effective Time. If, after the Effective Time, a valid certificate
previously representing any of such shares of Company Capital Stock (a "Company
Stock Certificate") is presented to the Surviving Corporation or Parent, such
Company Stock Certificate shall be canceled and shall be exchanged as provided
in Section 1.8.

          1.8  Exchange of Certificates; Escrow Shares.

               (a)  At or prior to the Effective Time, Parent shall reserve for
exchange in accordance with this Section 1, (i) the aggregate number of shares
of Parent Capital Stock issuable pursuant to Section 1.5 in exchange for
outstanding shares of Company Capital Stock and (ii) cash for fractional shares
in the amount described in Section 1.8(c). At the Closing, each Company
stockholder that does not perfect its appraisal rights and is otherwise entitled
to receive shares of Parent Capital Stock pursuant to Section 1.5 (a "Merger
Stockholder") shall surrender to Parent all certificates representing shares of
Company Capital Stock (properly endorsed for transfer). At or as soon as
practicable after the Effective Time, Parent shall (i) deliver to each Merger
Stockholder that is not a Major Stockholder certificates representing one
hundred percent (100%) of the number of whole shares of Parent Common Stock
and/or Parent Series D Preferred Stock, as the case may be, that such Merger
Stockholder has the right to receive pursuant to the provisions of Section 1.5
(ii) deliver to each Major Stockholder certificates

                                      7.
<PAGE>

representing eighty-five percent (85%) of the number of whole shares of Parent
Common Stock and/or Parent Series D Preferred Stock, as the case may be, that
such Merger Stockholder has the right to receive pursuant to the provisions of
Section 1.5 and (ii) deliver to the escrow agent under the Escrow Agreement in
the form of Exhibit C hereto (the "Escrow Agreement"), on behalf and in the name
of each Major Stockholder, certificates representing fifteen percent (15%) of
the number of whole shares of Parent Common Stock and/or Parent Series D
Preferred Stock, as the case may be, that such Major Stockholder has the right
to receive pursuant to the provisions of Section 1.5 (the "Escrow Shares"). If
any Company Stock Certificate shall have been lost, stolen or destroyed, Parent
may, in its discretion and as a condition precedent to the issuance of any
certificate representing Parent Capital Stock, require the owner of such lost,
stolen or destroyed Company Stock Certificate to provide an appropriate
affidavit and indemnity agreement against any claim that may be made against
Parent or the Surviving Corporation with respect to such Company Stock
Certificate.

          (b)  No dividends or other distributions declared or made with respect
to Parent Capital Stock with a record date after the Effective Time shall be
paid to the holder of any unsurrendered Company Stock Certificate with respect
to the shares of Parent Common Stock or Parent Series D Preferred Stock
represented thereby, and no cash payment in lieu of any fractional share shall
be paid to any such holder, until such holder surrenders such Company Stock
Certificate in accordance with this Section 1.8 or delivers the affidavit and
indemnity agreement referred to in Section 1.8(a) (at which time such holder
shall be entitled receive all such dividends and distributions and such cash
payment).

          (c)  No fractional shares of Parent Capital Stock shall be issued in
connection with the Merger, and no certificates for any such fractional shares
shall be issued. In lieu of such fractional shares, any holder of Company
Capital Stock who would otherwise be entitled to receive a fraction of a share
of Parent Common Stock (after aggregating all fractional shares of Parent Common
Stock issuable to such holder) and/or a fraction of a share of Parent Series D
Preferred Stock (after aggregating all fractional shares of Parent Series D
Preferred Stock issuable to such holder) shall, upon surrender of such holder's
Company Stock Certificate(s) or affidavit and indemnity agreement referred to in
Section 1.8(a), as the case may be, be paid in cash the dollar amount (rounded
to the nearest whole cent), without interest, determined by multiplying such
fraction by (i) $2.05, with respect to a fraction of a share of Parent Common
Stock, and (b) $14.27, with respect to a fraction of a share of Parent Series D
Preferred Stock.

          (d)  The shares of Parent Capital Stock to be issued in the Merger
shall be characterized as "restricted securities" for purposes of Rule 144 under
the Securities Act, and each certificate representing any such shares shall,
until such time that the shares are not so restricted under the Securities Act,
bear a legend identical or similar in effect to the following legend (together
with any other legend or legends required by applicable state securities laws or
otherwise, if any):

               "THE SHARES REPRESENTED BY THIS CERTIFICATE
          HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT
          OF 1933 (THE "ACT") AND MAY NOT BE OFFERED, SOLD
          OR OTHERWISE TRANSFERRED, ASSIGNED, PLEDGED OR
          HYPOTHECATED UNLESS

                            8.
<PAGE>

          REGISTERED UNDER THE ACT OR UNLESS AN EXEMPTION
          FROM THE REGISTRATION REQUIREMENTS OF THE ACT IS
          AVAILABLE."

          (e)  Parent and the Surviving Corporation shall be entitled to deduct
and withhold from any consideration payable or otherwise deliverable to any
holder or former holder of Company Capital Stock pursuant to this Agreement such
amounts as Parent or the Surviving Corporation may be required to deduct or
withhold therefrom under the Code or under any provision of state, local or
foreign tax law. To the extent such amounts are so deducted or withheld, such
amounts shall be treated for all purposes under this Agreement as having been
paid to the Person to whom such amounts would otherwise have been paid.

          (f)  Neither Parent nor the Surviving Corporation shall be liable to
any holder or former holder of Company Capital Stock for any shares of Parent
Capital Stock (or dividends or distributions with respect thereto), or for any
cash amounts, delivered to any public official pursuant to any applicable
abandoned property, escheat or similar law.

          (g)  The Escrow Shares shall be maintained in an escrow fund (the
"Escrow Fund") for purposes of satisfying claims brought pursuant to Section 9
and for the period of time set forth in the Escrow Agreement.

     1.9  Appraisal Rights.

          (a)  Notwithstanding anything to the contrary contained in this
Agreement, any shares of Company Capital Stock for which, as of the Effective
Time, the holder thereof has demanded an appraisal of their value in accordance
with Section 262 of the Delaware General Corporation Law ("Dissenting Shares")
shall not be converted into or represent the right to receive Parent Capital
Stock in accordance with Section 1.5, and the holder or holders of such shares
shall be entitled only to such rights as may be granted to such holder or
holders in Section 262 of the Delaware General Corporation Law; provided,
however, that if the status of any such shares as Dissenting Shares shall not be
perfected in accordance with Section 262 of the Delaware General Corporation
Law, or if any such shares shall lose their status as Dissenting Shares then, as
of the later of the Effective Time or the time of the failure to perfect such
status or the loss of such status, such shares shall automatically be converted
into and shall represent only the right to receive (upon the surrender of the
certificate or certificates representing such shares) Parent Capital Stock in
accordance with Section 1.5.

          (b)  The Company shall give Parent (i) prompt notice of any written
demand received by the Company at or prior to any meeting of the Company's
stockholders pursuant to Section 5.2 hereof to require the Company to purchase
Dissenting Shares pursuant to Section 262 of the Delaware General Corporation
Law and of any other demand, notice or instrument delivered to the Company prior
to the Effective Time pursuant to the Delaware General Corporation Law, and (ii)
the opportunity to participate in all negotiations and proceedings with respect
to any such demand, notice or instrument. The Company shall not make any payment
or settlement offer prior to the Effective Time with respect to any such demand
unless Parent shall have consented in writing to such payment or settlement
offer.

                                      9.
<PAGE>

          1.10 Tax Consequences. For federal income tax purposes, the Merger is
intended to constitute a reorganization within the meaning of Section 368 of the
Code. The parties to this Agreement hereby adopt this Agreement as a "plan of
reorganization" within the meaning of Sections 1.368-2(g) and 1.368-3(a) of the
United States Treasury Regulations.

          1.11 Accounting Treatment. For accounting purposes, the Merger is
intended to be treated as a "purchase."

          1.12 Further Action. If, at any time after the Effective Time, any
further action is determined by Parent to be necessary or desirable to carry out
the purposes of this Agreement or to vest the Surviving Corporation or Parent
with full right, title and possession of and to all rights and property of
Merger Sub and the Company, the officers and directors of the Surviving
Corporation and Parent shall be fully authorized (in the name of Merger Sub, in
the name of the Company and otherwise) to take such action.

SECTION 2. Representations and Warranties of the Company

               Except as set forth in the Company Disclosure Schedule, which
shall be arranged in paragraphs corresponding to the numbered and lettered
paragraphs contained in this Section 2, the Company represents and warrants, to
and for the benefit of the Parent Indemnitees, as follows:

     2.1 Due Organization; Subsidiaries; Etc.

               (a)  The Company has no Subsidiaries, except for the Entities
identified in Part 2.1(a)(i) of the Company Disclosure Schedule; and neither the
Company nor any of the other Entities identified in Part 2.1(a)(i) of the
Company Disclosure Schedule owns any capital stock of, or any equity interest of
any nature in, any other Entity, other than the Entities identified in Part
2.1(a)(ii) of the Company Disclosure Schedule. (The Company and each of its
Subsidiaries are referred to collectively in this Agreement as the "Acquired
Corporations.") Except as set forth in Part 2.1(a)(iii) of the Company
Disclosure Schedule, none of the Acquired Corporations has agreed or is
obligated to make, or is bound by any Contract under which it may become
obligated to make, any future investment in or capital contribution to any other
Entity. Except as set forth in Part 2.1(a)(iv) of the Company Disclosure
Schedule, none of the Acquired Corporations has, at any time, been a general
partner of, or has otherwise been liable for any of the debts or other
obligations of, any general partnership, limited partnership or other Entity.

               (b)  Each of the Acquired Corporations is a corporation duly
organized, validly existing and in good standing under the laws of the
jurisdiction of its incorporation and has all necessary power and authority: (i)
to conduct its business in the manner in which its business is currently being
conducted; (ii) to own and use its assets in the manner in which its assets are
currently owned and used; and (iii) to perform its obligations under all
Contracts by which it is bound.

               (c)  Each of the Acquired Corporations is qualified to do
business as a foreign corporation, and is in good standing, under the laws of
all jurisdictions where the nature of its business requires such qualification
and where the failure to be so qualified would reasonably be expected to have a
Material Adverse Effect on such Acquired Corporation. Part 2.1(c) of the

                                      10.
<PAGE>

Company Disclosure Schedule accurately sets forth for each of the respective
Acquired Corporations each jurisdiction where such qualification is required.

               (d)  Except as set forth in Part 2.1(d) of the Company Disclosure
Schedule, the Company has not conducted any business under or otherwise used,
for any purpose or in any jurisdiction, any fictitious name, assumed name, trade
name or other name, other than the name "PPGx, Inc."

               (e)  Part 2.1(e) of the Company Disclosure Schedule accurately
sets forth for each of the respective Acquired Corporations: (i) the names of
the members of the board of directors, (ii) the names of the members of each
committee of the board of directors, and (iii) the names and titles of each of
the officers.

          2.2  Certificate of Incorporation and Bylaws; Records. The Company has
delivered to Parent accurate and complete copies of: (1) the certificate of
incorporation, bylaws and other charter or similar organizational documents of
the respective Acquired Corporations, including all amendments thereto; (2)
stock records of each of the Acquired Corporations; and (3) except as set forth
in Part 2.2 of the Company Disclosure Schedule, the minutes and other records of
the meetings and other proceedings (including any actions taken by written
consent or otherwise without a meeting) of the stockholders, the board of
directors and all committees of the board of directors of each of the Acquired
Corporations. The stockholders and board of directors of the Company have
ratified, confirmed and approved all prior lawful action taken on behalf of the
Company by the Company's board of directors (in the case of ratification,
confirmation and approval by the Company's stockholders) and the Company's
officers (in the case of ratification, confirmation and approval by the
Company's board of directors). There has not been any violation of any of the
provisions of the certificate of incorporation, bylaws or other charter or
similar organizational documents of any of the Acquired Corporations, and none
of the Acquired Corporations has taken any action that is inconsistent in any
material respect with any resolution adopted by its stockholders, board of
directors or any committee of its board of directors. The books of account,
stock records, minute books and other records of each of the Acquired
Corporations are accurate, up-to-date and complete in all material respects, and
have been maintained in accordance with prudent business practices.

          2.3  Capitalization, Etc.

               (a)  As of the date of this Agreement, the authorized capital
stock of the Company consists of: (i) 15,000,000 shares of Company Common Stock,
of which 29,000 shares have been issued and are outstanding; and (ii) 10,000,000
shares of preferred stock (par value $0.001 per share), all of which have been
designated "Series A Preferred Stock," of which 10,000,000 shares have been
issued and are outstanding as of the date of this Agreement. Each outstanding
share of preferred stock is convertible into one share of Company Common Stock.
All of the outstanding shares of Company Common Stock and Company Series A
Preferred Stock have been duly authorized and validly issued, and are fully paid
and non-assessable. As of the date of this Agreement, there are no shares of
Company Capital Stock held by any of the other Acquired Corporations. Part
2.3(a) of the Company Disclosure Schedule provides an accurate and complete
description of the terms of each repurchase option which is held by the Company
and to which any of such shares is subject. Except as set forth in Part 2.3(a)
of the
                                      11.
<PAGE>

Company Disclosure Schedule, there is no Acquired Corporation Contract
relating to the voting or registration of, or restricting any Person from
purchasing, selling, pledging or otherwise disposing of (or granting any option
or similar right with respect to), any shares of Company Capital Stock. None of
the Acquired Corporations is under any obligation, or is bound by any Contract
pursuant to which it may become obligated, to repurchase, redeem or otherwise
acquire any outstanding shares of Company Capital Stock.

     (b) The Company has reserved 1,775,000 shares of Company Common Stock for
issuance under the Stock Plan, of which options to purchase 1,405,900 shares are
outstanding as of the date of this Agreement. Part 2.3(b) of the Company
Disclosure Schedule accurately sets forth, with respect to each Company Option
that is outstanding as of the date of this Agreement: (i) the name of the holder
of such Company Option; (ii) the total number of shares of Company Common Stock
that are subject to such Company Option and the number of shares of Company
Common Stock with respect to which such Company Option is immediately
exercisable; (iii) the date on which such Company Option was granted and the
term of such Company Option; (iv) the vesting schedule for such Company Option;
(v) the exercise price per share of Company Common Stock purchasable under such
Company Option; and (vi) whether such Company Option has been designated an
"incentive stock option" as defined in Section 422 of the Code.

     (c) Except as set forth in Part 2.3(b) or Part 2.3(c) of the Company
Disclosure Schedule, there is no: (i) outstanding subscription, option, call,
warrant or right (whether or not currently exercisable) to acquire any shares of
the capital stock or other securities of any of the Acquired Corporations; (ii)
outstanding security, instrument or obligation that is or may become convertible
into or exchangeable for any shares of the capital stock or other securities of
any of the Acquired Corporations; (iii) Contract under which any of the Acquired
Corporations is or may become obligated to sell or otherwise issue any shares of
its capital stock or any other securities; or (iv) to the Knowledge of the
Company, condition or circumstance that may give rise to or provide a basis for
the assertion of a claim by any Person to the effect that such Person is
entitled to acquire or receive any shares of capital stock or other securities
of the Acquired Corporations.

     (d) All outstanding shares of Company Common Stock and Company Series A
Preferred Stock, all outstanding Company Options and all outstanding shares of
capital stock of each Subsidiary of the Company have been issued and granted in
compliance with (i) all applicable securities laws and other applicable Legal
Requirements, and (ii) all requirements set forth in applicable Contracts.

     (e) Except as set forth in Part 2.3(e) of the Company Disclosure Schedule,
the Company has never repurchased, redeemed or otherwise reacquired any shares
of capital stock or other securities of the Company. All securities so
reacquired by the Company were reacquired in compliance with (i) the applicable
provisions of the Delaware General Corporation Law and all other applicable
Legal Requirements, and (ii) all requirements set forth in applicable restricted
stock purchase agreements and other applicable Contracts.

     (f) Except as set forth in Part 2.3(f) of the Company Disclosure Schedule,
all of the outstanding shares of capital stock or other ownership interests of
the Entities identified in Part 2.1(a) of the Company Disclosure Schedule that
have been issued to the Company have

                                      12.
<PAGE>

been duly authorized and are validly issued, are fully paid and nonassessable
and are owned beneficially and of record by the Company, free and clear of any
Encumbrances.

     2.4  Financial Statements.

          (a)  The Company has delivered to Parent the following financial
statements and notes (collectively, the "Acquired Corporation Financial
Statements"):

               (i)  The audited consolidated balance sheets of the Acquired
Corporations as of December 31, 1999, and the related audited consolidated
income statements, consolidated statements of stockholders' equity and
consolidated statements of cash flows for the Acquired Corporations for the year
then ended, together with the notes thereto and the unqualified report and
opinion of Ernst & Young relating thereto; and

               (ii) the unaudited consolidated balance sheet of the Acquired
Corporations as of September 30, 2000 (the "Unaudited Interim Balance Sheet"),
and the related unaudited consolidated income statement of the Acquired
Corporations for the nine months then ended.

          (b)  The Acquired Corporation Financial Statements are accurate and
complete in all material respects and present fairly the consolidated financial
position of the Acquired Corporations as of the respective dates thereof and the
consolidated results of operations and (in the case of the financial statements
referred to in Section 2.4(a)(i)) consolidated cash flows of the Acquired
Corporations for the periods covered thereby. The Acquired Corporation Financial
Statements have been prepared in accordance with generally accepted accounting
principles applied on a consistent basis throughout the periods covered (except
that the financial statements referred to in Section 2.4(a)(ii) do not contain
footnotes and are subject to normal and recurring year-end audit adjustments,
which will not, individually or in the aggregate, be material in magnitude).

     2.5  Absence of Changes. Except as set forth in Part 2.5 of the Company
Disclosure Schedule, since September 30, 2000:

          (a)  there has not been any material adverse change in the business,
     condition, assets, liabilities, operations or financial performance of the
     Acquired Corporations taken as a whole, and, to the Knowledge of the
     Company, no event has occurred that will, or could reasonably be expected
     to, have a Material Adverse Effect on the Acquired Corporations;

          (b)  there has not been any material loss, damage or destruction to,
     or any material interruption in the use of, any of the assets of any of the
     Acquired Corporations (whether or not covered by insurance);

          (c)  none of the Acquired Corporations has (i) declared, accrued, set
     aside or paid any dividend or made any other distribution in respect of any
     shares of capital stock, or (ii) repurchased, redeemed or otherwise
     reacquired any shares of capital stock or other securities;

                                      13.
<PAGE>

          (d)  none of the Acquired Corporations has sold, issued or authorized
     the issuance of (i) any capital stock or other security (except for Company
     Common Stock issued upon the exercise of outstanding Company Options), (ii)
     any option or right to acquire any capital stock or any other security
     (except for Company Options described in Part 2.3(b) of the Company
     Disclosure Schedule), or (iii) any instrument convertible into or
     exchangeable for any capital stock or other security;

          (e)  the Company has not amended or waived any of its rights under, or
     permitted the acceleration of vesting under, (i) any provision of the Stock
     Plan, (ii) any provision of any agreement evidencing any outstanding
     Company Option, or (iii) any restricted stock purchase agreement;

          (f)  there has been no amendment to the certificate of incorporation,
     bylaws or other charter or organizational documents of any of the Acquired
     Corporations, and none of the Acquired Corporations has effected or been a
     party to any Acquisition Transaction, recapitalization, reclassification of
     shares, stock split, reverse stock split or similar transaction;

          (g)  none of the Acquired Corporations has formed any Subsidiary or
     acquired any equity interest or other interest in any other Entity;

          (h)  none of the Acquired Corporations has made any capital
     expenditure which, when added to all other capital expenditures made on
     behalf of the Acquired Corporations since September 30, 2000, exceeds
     $500,000;

          (i)  none of the Acquired Corporations has amended or prematurely
     terminated, or waived any material right or remedy under, any Material
     Contract;

          (j)  none of the Acquired Corporations has (i) acquired, leased or
     licensed any right or other asset from any other Person, (ii) sold or
     otherwise disposed of, or leased or licensed, any right or other asset to
     any other Person, or (iii) waived or relinquished any right, except for
     immaterial rights or other immaterial assets acquired, leased, licensed or
     disposed of in the ordinary course of business and consistent with past
     practices;

          (k)  none of the Acquired Corporations has written off as
     uncollectible, or established any extraordinary reserve with respect to,
     any account receivable or other indebtedness;

          (l)  none of the Acquired Corporations has made any pledge of any of
     its assets or otherwise permitted any of its assets to become subject to
     any Encumbrance, except for pledges of immaterial assets made in the
     ordinary course of business and consistent with past practices;

          (m)  none of the Acquired Corporations has (i) lent money to any
     Person (other than pursuant to routine travel advances made to employees in
     the ordinary course of business), or (ii) incurred or guaranteed any
     indebtedness for borrowed money;

                                      14.
<PAGE>

          (n)  none of the Acquired Corporations has, outside the ordinary
     course of business or inconsistent with past practices, (i) established or
     adopted any Employee Benefit Plan, (ii) paid any bonus or made any profit-
     sharing or similar payment to, or increased the amount of the wages,
     salary, commissions, fringe benefits or other compensation or remuneration
     payable to, any of its directors, officers or employees, or (iii) hired any
     new employee;

          (o)  none of the Acquired Corporations has changed any of its methods
     of accounting or accounting practices in any respect;

          (p)  none of the Acquired Corporations has made any material Tax
     election;

          (q)  none of the Acquired Corporations has commenced or settled any
     Legal Proceeding;

          (r)  none of the Acquired Corporations has entered into any material
     transaction or taken any other material action outside the ordinary course
     of business or inconsistent with past practices; and

          (s)  none of the Acquired Corporations has agreed or committed to take
     any of the actions referred to in clauses "(c)" through "(r)" above.

     2.6  Title to Assets. The Acquired Corporations own, and have good and
marketable title to, all of the assets purported to be owned by them, including:
(i) all assets reflected on the Unaudited Interim Balance Sheet; (ii) all of the
rights of the Acquired Corporations under the Contracts identified in Part 2.10
of the Company Disclosure Schedule; and (iii) all other assets reflected in the
books and records of the Acquired Corporations as being owned by the Acquired
Corporations. Except as set forth in Part 2.6 of the Company Disclosure
Schedule, all of such assets are owned by the Acquired Corporations free and
clear of any liens or other Encumbrances, except for (x) any lien for current
taxes not yet due and payable, (y) minor liens that have arisen in the ordinary
course of business and that do not (in any case or in the aggregate) materially
detract from the value of the assets subject thereto or materially impair the
operations of any of the Acquired Corporations and (z) Permitted Encumbrances.

     2.7  Bank Accounts; Receivables.

          (a)  Part 2.7(a) of the Company Disclosure Schedule accurately sets
forth, with respect to each account or credit line maintained by or for the
benefit of each Acquired Corporation at any bank or financial institution:

               (i)    the name and location of the institution at which such
account or credit line is maintained;

               (ii)   the name in which such account or credit line is
maintained and the account number of such account or credit line;

               (iii)  a description of such account or credit line and the
purpose for which such account or credit line is used;

                                      15.
<PAGE>

               (iv)  the current balance in such account or amount owed under
such credit line;

               (v)   the rate of interest being earned on the funds in such
account or charged under such credit line; and

               (vi)  the names of all individuals authorized to draw on or make
withdrawals from such account or to borrow against such credit line.

          (b)  Except as set forth in Part 2.7(b)(i) of the Company Disclosure
Schedule, all existing accounts receivable of the Acquired Corporations
(including those accounts receivable reflected on the Unaudited Interim Balance
Sheet that have not yet been collected and those accounts receivable that have
arisen since September 30, 2000 and have not yet been collected) represent valid
obligations of customers of the Acquired Corporations arising from bona fide
transactions entered into in the ordinary course of business. Part 2.7(b)(ii) of
the Company Disclosure Schedule accurately identifies, and provides an accurate
and complete breakdown of the revenues received from, each customer or other
Person that accounted for (i) more than $175,000 of the consolidated gross
revenues of the Acquired Corporations in the fiscal year ended December 31,
1999, or (ii) more than $175,000 of the consolidated gross revenues of the
Acquired Corporations in the nine-month period ended September 30, 2000 (each, a
"Material Customer")(it being understood that for purposes of clauses "(i)" and
"(ii)" of this sentence, a "Material Customer" of an Acquired Corporation
includes any Person to which PPD provides "Designated Services" or "Designated
Products" (as such terms are defined in the Distributor Agreement dated February
1, 2000 between the Company and PPD (the "Distributor Agreement")) in accordance
with the terms of the Distributor Agreement). Except as set forth in Part
2.7(c)(iii) of the Company Disclosure Schedule, the Company has not received any
notice or other communication (in writing or otherwise), and, to the Knowledge
of the Company, has not received any other information, indicating that (a) any
Material Customer is likely to cease dealing with the Company or (b) any
Material Customer is dissatisfied in any material respect with the operation of
any product, system or program currently maintained, sold or licensed by any of
the Acquired Corporations or with any services performed by any of the Acquired
Corporations since January 1, 1999.

     2.8  Equipment; Leasehold.

          (a)  All material items of equipment and other tangible assets owned
by or leased to the Acquired Corporations are, in the reasonable judgment of the
Acquired Corporations, adequate for the uses to which they are being put, are in
good condition and repair (ordinary wear and tear excepted) and are adequate for
the conduct of the business of the Acquired Corporations in the manner in which
such businesses are currently being conducted.

          (b)  None of the Acquired Corporations own any real property or any
interest in real property, except for the leaseholds created under the real
property leases identified in Part 2.8 of the Company Disclosure Schedule.

     2.9  Proprietary Assets.

                                      16.
<PAGE>

          (a)  Part 2.9(a)(i) of the Company Disclosure Schedule sets forth,
with respect to each Acquired Corporation Proprietary Asset registered with any
Governmental Body or for which an application has been filed with any
Governmental Body, (i) a brief description of such Acquired Corporation
Proprietary Asset, and (ii) the names of the jurisdictions covered by the
applicable registration or application. Part 2.9(a)(ii) of the Company
Disclosure Schedule identifies and provides a brief description of each
Proprietary Asset (other than trade secrets, know-how or customer list) owned by
any of the Acquired Corporations. Part 2.9(a)(iii) of the Company Disclosure
Schedule identifies and provides a brief description of, and identifies any
ongoing royalty or payment obligations in excess of $10,000 annually with
respect to, each Proprietary Asset that is licensed or otherwise made available
to any of the Acquired Corporations by any Person and is material to the
business of the Acquired Corporations (except for any Proprietary Asset that is
licensed to any Acquired Corporation under any third party software license
generally available to the public), and identifies the Contract under which such
Proprietary Asset is being licensed or otherwise made available to such Acquired
Corporation. Except as set forth in Part 2.9(a)(iv) of the Company Disclosure
Schedule, each of the Acquired Corporations has good and valid title to, and
exclusive ownership of or exclusive license to use, all of their respective
Proprietary Assets identified or required to be identified in Parts 2.9(a)(i)
and 2.9(a)(ii) of the Company Disclosure Schedule that are material to the
conduct of the business of the Acquired Corporations, free and clear of all
Encumbrances. All of the rights of the Acquired Corporations in all of such
Proprietary Assets are freely transferable, and each of the Acquired
Corporations has a valid right to use, license and otherwise exploit all
Proprietary Assets identified in Part 2.9(a)(iii) of the Company Disclosure
Schedule. Except as set forth in Part 2.9(a)(v) of the Company Disclosure
Schedule, none of the Acquired Corporations has developed jointly with any other
Person any Acquired Corporation Proprietary Asset with respect to which such
other Person has any rights. Except as set forth in Part 2.9(a)(vi) of the
Company Disclosure Schedule, there is no Acquired Corporation Contract pursuant
to which any Person has any right (whether or not currently exercisable) to use,
license or otherwise exploit any Acquired Corporation Proprietary Asset or any
Acquired Corporation Proprietary Asset that may be developed in the future.

          (b)  Except as set forth in Part 2.9(b)(i) of the Company Disclosure
Schedule, all such Proprietary Assets have been duly registered with, filed with
or issued by the United States Patent and Trademark Office, the United States
Register of Copyrights, or the corresponding offices of other jurisdictions as
identified in the Company Disclosure Schedule, and have been properly maintained
and renewed in accordance with all applicable provisions of law and
administrative regulations of the United States and each such jurisdiction and,
except as stated in Part 2.9(b)(ii) of the Company Disclosure Schedule, all of
the rights and Proprietary Assets of the Acquired Corporations thereunder are
freely assignable without the consent of any Person.

          (c)  Part 2.9(c)(i) of the Company Disclosure Schedule sets forth all
licenses or other Contracts under which the Acquired Corporations are granted
rights in Proprietary Assets. Except as set forth in Part 2.9(c)(ii), all such
licenses or other Contracts are in full force and effect, there is no material
default by any Acquired Corporation or, to the Knowledge of the Company, by any
other party thereto, and, except as set forth in Part 2.9(c)(iii), all of the
rights of the Acquired Corporations thereunder are freely assignable without the
consent of any Person. Except as set forth in Part 2.9(c)(iv), to the Knowledge
of the Company, the licensors under said

                                      17.
<PAGE>

licenses and other Contracts have and had all requisite power and authority to
grant the rights purported to be conferred thereby. True and complete copies of
all such licenses or other Contracts, and any amendments thereto, have been
provided to Parent.

          (d)  Each of the Acquired Corporations has taken reasonable measures
and precautions to protect and maintain the confidentiality, secrecy and value
of all material Acquired Corporation Proprietary Assets (except Acquired
Corporation Proprietary Assets whose value would be unimpaired by disclosure).
Without limiting the generality of the foregoing, except as set forth in Part
2.9(d) of the Company Disclosure Schedule, (i) each current or former employee
of any Acquired Corporation who is or was involved in, or who has contributed
to, the creation or development of any material Acquired Corporation Proprietary
Asset has executed and delivered to such Acquired Corporation an agreement
(containing no exceptions to or exclusions from the scope of its coverage) that
is substantially identical to the form of the Company's Employment, Confidential
Information and Invention Assignment Agreement previously delivered by the
Company to Parent, and (ii) each current and former consultant and independent
contractor to any Acquired Corporation who is or was involved in, or who has
contributed to, the creation or development of any material Acquired Corporation
Proprietary Asset has executed and delivered to the Company an agreement
(containing no material exceptions to or exclusions from the scope of its
coverage) that is substantially identical to the form of the Company's
Employment, Confidential Information and Invention Assignment Agreement
previously delivered to Parent. No current or former employee, officer,
director, stockholder, consultant or independent contractor has any right, claim
or interest in or with respect to any material Acquired Corporation Proprietary
Asset.

          (e)  To the Knowledge of the Company: (i) all patents, trademarks,
service marks and copyrights held by any of the Acquired Corporations are valid,
enforceable and subsisting; (ii) none of the Acquired Corporation Proprietary
Assets and no Proprietary Asset that is currently being developed by any of the
Acquired Corporations (either by itself or with any other Person)
misappropriates any Proprietary Asset owned or used by any other Person, and the
use of Acquired Corporation Proprietary Assets in their intended or contemplated
manner does not require a license under or other rights to use any Proprietary
Asset owned by any other Person; (iii) none of the products, formula,
compositions of matter, inventions, designs, technology, proprietary rights or
other intellectual property rights or intangible assets that is or has been
designed, created, developed, assembled, manufactured or sold by any of the
Acquired Corporations is infringing, misappropriating or making any unlawful or
unauthorized use of any Proprietary Asset owned or used by any other Person, and
none of such products has at any time infringed, misappropriated or made any
unlawful or unauthorized use of any Proprietary Asset owned or used by any other
Person; (iv) except as set forth in Part 2.9(e) of the Company Disclosure
Schedule, none of the Acquired Corporations has received any notice or other
communication (in writing or otherwise) of any actual, alleged, possible or
potential infringement, misappropriation or unlawful or unauthorized use of, any
Proprietary Asset owned or used by any other Person; and (v) no other Person is
infringing, misappropriating or making any unlawful or unauthorized use of any
material Acquired Corporation Proprietary Asset.

          (f)  To the Knowledge of the Company, the Acquired Corporation
Proprietary Assets constitute all the Proprietary Assets necessary to enable the
Acquired Corporations to conduct their business in the manner in which such
business is presently being conducted.

                                      18.
<PAGE>

Except as set forth in Part 2.9(f) of the Company Disclosure Schedule, none of
the Acquired Corporations has (i) licensed any of the Acquired Corporation
Proprietary Assets to any Person on an exclusive basis, or (ii) entered into any
covenant not to compete or Contract limiting or purporting to limit the ability
of any Acquired Corporation to exploit fully any material Acquired Corporation
Proprietary Assets or to transact business in any market or geographical area or
with any Person.

          (g)  Notwithstanding the generality of anything stated in this Section
2.9, the Company owns (and immediately after the Effective Time, the Surviving
Corporation shall own), subject to Third-Party Rights, the entire right, title
and interest in and to the DNA Sample Library and any information, including but
not limited to, genotypic and phenotypic information, derived or developed by
the Company from the DNA Sample Library. All right, title and interest owned by
the Company in and to the DNA Sample Library and information derived or
developed by the Company from the DNA Sample Library is freely transferable,
subject only to the Third Party Rights. For purposes of this Agreement: (1) the
"DNA Sample Library" means the library of DNA specimens identified in Part
2.9(g) of the Company Disclosure Schedule; and (2) "Third-Party Rights" means
those rights retained by Persons other than the Company and/or the Major
Stockholders pursuant to those Contracts identified in Part 2.9(g) of the
Company Disclosure Schedule.

     2.10 Contracts.

          (a)  Part 2.10 of the Company Disclosure Schedule identifies each
Acquired Corporation Contract that constitutes a "Material Contract" as of the
date of this Agreement. For purposes of this Agreement, each of the following
Contracts (to the extent that any of the Acquired Corporations has (or may have)
any liability or obligation thereunder or with respect thereto after the date of
this Agreement) shall be deemed to constitute a "Material Contract":

               (i)    each Contract relating to the employment of, or the
performance of services by, any employee or consultant (other than any offer
letter provided to any employee of any of the Acquired Corporations which
provides for "at will" employment);

               (ii)   each Contract pursuant to which any of the Acquired
Corporations is or may become obligated to make any severance, termination or
similar payment to any current or former employee or director; and any Contract
pursuant to which any of the Acquired Corporations is or may become obligated to
make any bonus or similar payment (other than payments in respect of salary or
commissions) in excess of $15,000 to any current or former employee or director;

               (iii)  each Contract with a face value of $25,000 (A) with any
customer of any of the Acquired Corporations except for standard purchase
orders; or (B) with respect to the distribution or marketing of any product of
any of the Acquired Corporations;

               (iv)   each Contract relating to the acquisition, transfer,
development, sharing or license of any Acquired Corporation Proprietary Asset
(except for any Contract pursuant to which any Proprietary Asset is licensed by
any of the Acquired Corporations to any Person (other than a Major Stockholder)
on a non-exclusive basis);

                                      19.
<PAGE>

               (v)    each Contract which provides for indemnification of any
officer, director, employee or agent;

               (vi)   each Contract creating or relating to any partnership or
joint venture or any sharing of revenues, profits, losses, costs or liabilities;

               (vii)  each Contract relating to the purchase or sale of any
product or other asset by or to, or the performance of any services by or for,
any Related Party;

               (viii) each Contract imposing any restriction on the right or
ability of any Acquired Corporation (A) to compete with any other Person, (B) to
acquire any material product or other asset or any services from any other
Person, (C) to solicit, hire or retain any Person as an employee, consultant or
independent contractor, (D) to develop, sell, supply, distribute, offer, support
or service any product or any technology or other asset to or for any other
Person, (E) to perform services for any other Person or (F) to transact business
or deal in any other manner with any other Person;

               (ix)   each Contract creating or involving any agency
relationship, distribution arrangement or franchise relationship;

               (x)    each Contract relating to the creation of any Encumbrance
(except Permitted Encumbrances) with respect to any asset of any of the Acquired
Corporations;

               (xi)   each Contract (A) relating to the acquisition, issuance,
voting, registration, sale or transfer of any securities, other than pursuant to
the Company Options, (B) providing any Person with any preemptive right, right
of participation, right of maintenance or any similar right with respect to any
securities or (C) providing any of the Acquired Corporations with any right of
first refusal with respect to, or right to purchase or otherwise acquire, any
securities;

               (xii)  each Contract incorporating or relating to any guaranty or
any indemnity or similar obligation, except for Contracts entered into in the
ordinary course of business;

               (xiii) each Contract relating to any currency hedging;

               (xiv)  each Contract imposing any confidentiality obligation on
any of the Acquired Corporations other than nondisclosure agreements entered
into in the ordinary course of business;

               (xv)   each Contract to which any Governmental Body is a party;
and any other Contract directly or indirectly benefiting any Governmental Body
(including any subcontract or other Contract between any Acquired Corporation
and any contractor or subcontractor to any Governmental Body), except for
Contracts entered into in the ordinary course of business for the license,
maintenance or service of products;

                                      20.
<PAGE>

               (xvi)   each Contract with obligations in excess of $50,000 that
has a term of more than 60 days and that may not be terminated by an Acquired
Corporation (without penalty) within 60 days after the delivery of a termination
notice by such Acquired Corporation;

               (xvii)  each Contract that contemplates or involves the payment
or delivery of cash or other consideration in an amount or having a value in
excess of $50,000 in the aggregate, or contemplates or involves the performance
of services having a value in excess of $50,000 in the aggregate;

               (xviii) each Contract requiring that any of the Acquired
Corporations give any notice or provide any information to any Person prior to
considering or accepting any Acquisition Proposal or similar proposal, or prior
to entering into any discussions, agreement, arrangement or understanding
relating to any Acquisition Transaction or similar transaction;

               (xix)   each Contract that (A) contemplates or involves the
payment or delivery of cash or other consideration by any of the Acquired
Corporations in an amount or having a value in excess of $100,000 in the
aggregate, (B) contemplates or involves the payment or delivery of cash or other
consideration to any of the Acquired Corporations in an amount or having a value
in excess of $100,000 in the aggregate or (C) contemplates or involves the
performance of services by any of the Acquired Corporations having a value in
excess of $100,000 in the aggregate;

               (xx)    each Contract that could reasonably be expected to have a
material effect on (A) the business, condition, capitalization, assets,
liabilities, operations, financial performance of any of the Acquired
Corporations or (B) the ability of the Company to perform any of its obligations
under, or to consummate any of the transactions contemplated by, this Agreement;
and

               (xxi)   each Contract (not otherwise identified in clauses "(i)"
through "(xx)" of this sentence) with a Major Stockholder and/or one or more of
its Subsidiaries.

          (b)  The Company has delivered to Parent and to Cooley Godward LLP an
accurate and complete copy of each Material Contract.

          (c)  Each Acquired Corporation Contract is valid and in full force and
effect, and is enforceable in accordance with its terms, subject to (i) laws of
general application relating to bankruptcy, insolvency and the relief of
debtors, and (ii) applicable Legal Requirements governing specific performance,
injunctive relief and other equitable remedies, except where the failure to be
valid and binding and in full force and effect would not individually or in the
aggregate have a Material Adverse Effect on the Acquired Corporations.

          (d)  Except as set forth in Part 2.10(d) of the Company Disclosure
Schedule: (i) none of the Acquired Corporations has violated or breached, or
committed any default under, any Acquired Corporation Contract, except for
violations, breaches and defaults that have not had and would not reasonably be
expected to have a Material Adverse Effect on the Acquired Corporations; and, to
the Knowledge of the Company, no other Person has violated or breached, or
committed any default under, any Acquired Corporation Contract, except for
violations, breaches or defaults that have not had and would not reasonably be
expected to have a Material

                                      21.
<PAGE>

Adverse Effect on the Acquired Corporations; (ii) to the Knowledge of the
Company, no event has occurred, and no circumstance or condition exists, that
(with or without notice or lapse of time) will, or would reasonably be expected
to, (A) result in a violation or breach of any of the provisions of any Acquired
Corporation Contract, (B) give any Person the right to declare a default or
exercise any remedy under any Acquired Corporation Contract, (C) give any Person
the right to receive or require a rebate, chargeback or penalty under any
Acquired Corporation Contract, (D) give any Person the right to accelerate the
maturity or performance of any Acquired Corporation Contract, or (E) give any
Person the right to cancel, terminate or modify any Acquired Corporation
Contract, except in each such case for defaults, acceleration rights,
termination rights and other rights that have not had and would not reasonably
be expected to have a Material Adverse Effect on the Acquired Corporations; and
(iii) since January 1, 1999, none of the Acquired Corporations has received any
notice or other communication regarding any actual or possible violation or
breach of, or default under, any Acquired Corporation Contract, except in each
such case for defaults, acceleration rights, termination rights and other rights
that have not had and would not reasonably be expected to have a Material
Adverse Effect on the Acquired Corporations.

     2.11  Liabilities. None of the Acquired Corporations has accrued,
contingent or other liabilities of any nature, either matured or unmatured
(whether or not required to be reflected in financial statements in accordance
with generally accepted accounting principles, and whether due or to become
due), except for: (a) liabilities identified as such in the "liabilities" column
of the Unaudited Interim Balance Sheet; (b) accounts payable or accrued salaries
that have been incurred by the Acquired Corporations since September 30, 2000 in
the ordinary course of business and consistent with past practices; (c)
liabilities under the Acquired Corporation Contracts identified in Part 2.10 of
the Company Disclosure Schedule, to the extent the nature and magnitude of such
liabilities can be specifically ascertained by reference to the text of such
Acquired Corporation Contracts; and (d) the liabilities identified in Part 2.11
of the Company Disclosure Schedule.

     2.12  Compliance with Legal Requirements. Each of the Acquired Corporations
is, and has at all times since January 1, 1999 been, in compliance with all
applicable Legal Requirements, except where the failure to comply with such
Legal Requirements has not had and will not have a Material Adverse Effect on
the Acquired Corporations. Except as set forth in Part 2.12 of the Company
Disclosure Schedule, since January 1, 1999, none of the Acquired Corporations
has received any notice or other communication from any Governmental Body
regarding any actual or possible violation (or of any pending or threatened
investigation, inspection, audit or other proceeding by any Governmental Body
involving allegations of any violation) of, or failure to comply with, any Legal
Requirement. To the Knowledge of the Company, no investigation, inspection,
audit or other proceeding by Governmental Body involving allegations of any
violation of any Legal Requirement is contemplated by any such Governmental
Body.

     2.13  Governmental Authorizations and Facility Certifications.

           (a)   Part 2.13(a) of the Company Disclosure Schedule identifies each
material Governmental Authorization held by the Acquired Corporations (and
contains a summary description of each such Governmental Authorization and,
where applicable, specifies the date

                                      22.
<PAGE>

issued, granted or applied for, the expiration date and the current status
thereof), and the Company has delivered to Parent accurate and complete copies
of all Governmental Authorizations identified in Part 2.13(a) of the Company
Disclosure Schedule.

            (b) The Governmental Authorizations identified in Part 2.13(a) of
the Company Disclosure Schedule are valid and in full force and effect (and, to
the Knowledge of the Company, no revocation, withdrawal, suspension,
cancellation, termination or modification thereof has been threatened), and
collectively constitute all Governmental Authorizations necessary to enable the
Acquired Corporations to conduct their respective businesses in the manner in
which such businesses are currently being conducted, except where the failure to
hold such Governmental Authorizations has not had, and based on applicable Legal
Requirements as in effect on the date hereof would not reasonably be expected to
have, a Material Adverse Effect on the Acquired Corporations. Each of the
Acquired Corporations is, and at all times since January 1, 1999 has been, in
substantial compliance with the terms and requirements of such Governmental
Authorizations, except where the failure to be in compliance with the terms and
requirements of such Governmental Authorizations has not had, and based on
applicable Legal Requirements as in effect on the date hereof would not
reasonably be expected to have, a Material Adverse Effect on any of the Acquired
Corporations. Since January 1, 1999, none of the Acquired Corporations has
received any written notice from any Governmental Body regarding (a) any actual
or possible violation of or failure to comply with any term or requirement of
any material Governmental Authorization, or (b) any actual or possible
revocation, withdrawal, suspension, cancellation, termination or modification of
any material Governmental Authorization.

            (c) The certifications identified in Part 2.13(c) of the Company
Disclosure Schedule are valid and in full force and effect (and, to the
Knowledge of the Company, no revocation, withdrawal, suspension, cancellation,
termination, modification or limitation thereof has been threatened). Each of
the Acquired Corporations is, and at all times since January 1, 1999 has been,
in substantial compliance with the terms and requirements of such
certifications, except where the failure to be in compliance with the terms and
requirements of such certifications has not had, and based on the terms of such
certifications would not reasonably be expected to have, a Material Adverse
Effect on any of the Acquired Corporations. Since January 1, 1999, none of the
Acquired Corporations has received any written notice from the Person that
issued each such certification regarding (a) any actual or possible violation of
or failure to comply with any term or requirement of such certification, or (b)
any actual or possible revocation, withdrawal, suspension, cancellation,
termination, modification or limitation of such certification.

     2.14   Tax Matters.

            (a) Each of the Tax Returns relating to income taxes required to be
filed by or on behalf of the respective Acquired Corporations with any
Governmental Body with respect to any taxable period ending on or before the
Closing has been or will be filed on or before the applicable due date
(including any extensions of such due date). Each of the Tax Returns required to
be filed by or on behalf of the respective Acquired Corporations with any
Governmental Body with respect to any taxable period ending on or before the
Closing (the "Acquired Corporation Returns") has been, or will be when filed,
accurately and completely

                                      23.
<PAGE>

prepared in all material respects in compliance with all applicable Legal
Requirements. All amounts shown on the Acquired Corporation Returns to be due on
or before the Closing have been or will be paid on or before the Closing. The
Company has delivered to Parent accurate and complete copies of all Acquired
Corporation Returns filed since December 31, 1999 which have been requested by
Parent.

            (b) The Financial Statements of the Acquired Corporations fully
accrue all actual and contingent liabilities for Taxes with respect to all
periods through the dates thereof in accordance with generally accepted
accounting principles. The Acquired Corporations will establish, in the ordinary
course of business and consistent with its past practices, reserves adequate for
the payment of all Taxes for the period from September 30, 2000 through the
Closing, and the Company will disclose the dollar amount of such reserves to
Parent on or prior to the Closing.

            (c) No Acquired Corporation Return has ever been examined or audited
by any Governmental Body. Except as set forth in Part 2.14 of the Company
Disclosure Schedule, there have been no examinations or audits of any Acquired
Corporation Returns. The Company has delivered to Parent accurate and complete
copies of all audit reports and similar documents (to which the Company has
access) relating to the Acquired Corporation Returns. Except as set forth in
Part 2.14 of the Company Disclosure Schedule, no extension or waiver of the
limitation period applicable to any of the Acquired Corporation Returns has been
granted (by the Company or any other Person), and no such extension or waiver
has been requested from any Acquired Corporation.

            (d) Except as set forth in Part 2.14 of the Company Disclosure
Schedule, no claim or Proceeding is, to the Knowledge of the Company, pending or
has been threatened against or with respect to any Acquired Corporation in
respect of any Tax. There are no unsatisfied liabilities for Taxes (including
liabilities for interest, additions to tax and penalties thereon and related
expenses) with respect to any notice of deficiency or similar document received
by any of the Acquired Corporations with respect to any Tax (other than
liabilities for Taxes asserted under any such notice of deficiency or similar
document which are being contested in good faith by the Acquired Corporations
and with respect to which adequate reserves for payment have been established).
There are no liens for Taxes upon any of the assets of any of the Acquired
Corporations except liens for current Taxes not yet due and payable. None of the
Acquired Corporations has entered into or become bound by any agreement or
consent pursuant to Section 341(f) of the Code. None of the Acquired
Corporations has been, and none of the Acquired Corporations will be, required
to include any adjustment in taxable income for any tax period (or portion
thereof) pursuant to Section 481 or 263A of the Code or any comparable provision
under state or foreign Tax laws as a result of transactions or events occurring,
or accounting methods employed, prior to the Closing.

            (e) There is no agreement, plan, arrangement or other Contract
covering any employee or independent contractor or former employee or
independent contractor of any of the Acquired Corporations that, considered
individually or considered collectively with any other such Contracts, will, or
could reasonably be expected to, give rise directly or indirectly to the payment
of any amount that would not be deductible pursuant to Section 280G or Section
162 of

                                      24.
<PAGE>

the Code. None of the Acquired Corporations are, or have ever been, a party to
or bound by any tax indemnity agreement, tax-sharing agreement, tax allocation
agreement or similar Contract.

     2.15   Employee and Labor Matters; Benefit Plans.

            (a) Part 2.15(a) of the Company Disclosure Schedule identifies each
bonus, deferred compensation, incentive compensation, stock purchase, stock
option, severance pay, termination pay, hospitalization, medical, life or other
insurance, supplemental unemployment benefits, profit-sharing, pension or
retirement plan, program or agreement (collectively, the "Plans") sponsored,
maintained, contributed to or required to be contributed to by any of the
Acquired Corporations for the benefit of any employee of any of the Acquired
Corporations ("Employee"), except for (1) Plans which would not require any of
the Acquired Corporations to make payments or provide benefits having a value in
excess of $25,000 in the aggregate and (2) except for the Company's 2000 Merit
Compensation Plan and 2000 Incentive Compensation Plant.

            (b) Except as set forth in Part 2.15(b) of the Company Disclosure
Schedule, none of the Acquired Corporations maintains, sponsors or contributes
to, and, to the Knowledge of the Company, none of the Acquired Corporations has
at any time in the past maintained, sponsored or contributed to, any employee
pension benefit plan (as defined in Section 3(2) of the Employee Retirement
Income Security Act of 1974, as amended ("ERISA"), whether or not excluded from
coverage under specific Titles or Merger Subtitles of ERISA) for the benefit of
Employees or former Employees (a "Pension Plan").

            (c) Each of the Acquired Corporations maintains, sponsors or
contributes only to those employee welfare benefit plans (as defined in Section
3(1) of ERISA, whether or not excluded from coverage under specific Titles or
Merger Subtitles of ERISA) for the benefit of Employees or former Employees
which are described in Part 2.15(c) of the Company Disclosure Schedule (the
"Welfare Plans"), none of which is a multiemployer plan (within the meaning of
Section 3(37) of ERISA).

            (d) With respect to each Plan, the Company has delivered or made
available to Parent:

                (i)   an accurate and complete copy of such Plan (including all
amendments thereto);

                (ii)  an accurate and complete copy of the annual report, if
required under ERISA, with respect to such Plan for the last two years;

                (iii) an accurate and complete copy of the most recent summary
plan description, together with each Summary of Material Modifications, if
required under ERISA, with respect to such Plan, and all material employee
communications relating to such Plan;

                (iv)  if such Plan is funded through a trust or any third party
funding vehicle, an accurate and complete copy of the trust or other funding
agreement (including all amendments thereto) and accurate and complete copies
the most recent financial statements thereof;

                                      25.
<PAGE>

                (v)  accurate and complete copies of all Contracts relating to
such Plan, including service provider agreements, insurance contracts, minimum
premium contracts, stop-loss agreements, investment management agreements,
subscription and participation agreements and recordkeeping agreements; and

                (vi) an accurate and complete copy of the most recent
determination letter received from the Internal Revenue Service with respect to
such Plan (if such Plan is intended to be qualified under Section 401(a) of the
Code).

            (e) None of the Acquired Corporations are required to be, and, to
the Knowledge of the Company, has ever been required to be, treated as a single
employer with any other Person under Section 4001(b)(1) of ERISA or Section
414(b), (c), (m) or (o) of the Code. None of the Acquired Corporations has ever
been a member of an "affiliated service group" within the meaning of Section
414(m) of the Code. To the Knowledge of the Company, none of the Acquired
Corporations has ever made a complete or partial withdrawal from a multiemployer
plan, as such term is defined in Section 3(37) of ERISA, resulting in
"withdrawal liability," as such term is defined in Section 4201 of ERISA
(without regard to subsequent reduction or waiver of such liability under either
Section 4207 or 4208 of ERISA).

            (f) None of the Acquired Corporations has any plan or commitment to
create any additional Welfare Plan or any Pension Plan, or to modify or change
any existing Welfare Plan or Pension Plan (other than to comply with applicable
law) in a manner that would affect any Employee.

            (g) Except as set forth in Part 2.15(g) of the Company Disclosure
Schedule, no Welfare Plan provides death, medical or health benefits (whether or
not insured) with respect to any current or former Employee after any such
Employee's termination of service (other than (i) benefit coverage mandated by
applicable law, including coverage provided pursuant to Section 4980B of the
Code, (ii) deferred compensation benefits accrued as liabilities on the
Unaudited Interim Balance Sheet, and (iii) benefits the full cost of which are
borne by current or former Employees (or the Employees' beneficiaries)).

            (h) With respect to each of the Welfare Plans constituting a group
health plan within the meaning of Section 4980B(g)(2) of the Code, the
provisions of Section 4980B of the Code ("COBRA") have been complied with in all
material respects.

            (i) Each of the Plans has been operated and administered in all
material respects in accordance with applicable Legal Requirements, including
but not limited to ERISA and the Code.

            (j) Each of the Plans intended to be qualified under Section 401(a)
of the Code has received a favorable determination from the Internal Revenue
Service, and the Company is not aware of any reason why any such determination
letter should be revoked.

            (k) Except as set forth in Part 2.15(k) of the Company Disclosure
Schedule, neither the execution, delivery or performance of this Agreement, nor
the consummation of the Merger or any of the other transactions contemplated by
this Agreement, will result in any payment (including any bonus, golden
parachute or severance payment) to any current or former

                                      26.
<PAGE>

Employee or director of any of the Acquired Corporations (whether or not under
any Plan), or materially increase the benefits payable under any Plan, or result
in any acceleration of the time of payment or vesting of any such benefits.

            (l) The Company has provided Parent a list of all salaried employees
of each of the Acquired Corporations as of the date of this Agreement, and such
list correctly reflects, in all material respects, their salaries, any other
compensation payable to them (including compensation payable pursuant to bonus,
deferred compensation or commission arrangements), their dates of employment and
their positions. None of the Acquired Corporations is a party to any collective
bargaining contract or other Contract with a labor union representing any of its
Employees. All of the employees of the Acquired Corporations are "at will"
employees.

            (m) Part 2.15(m) of the Company Disclosure Schedule identifies each
Employee who is not fully available to perform work because of disability or
other leave and sets forth the basis of such leave and the anticipated date of
return to full service.

            (n) Each of the Acquired Corporations is in compliance in all
material respects with all applicable Legal Requirements and Contracts relating
to employment, employment practices, wages, bonuses and terms and conditions of
employment, including employee compensation matters.

            (o) Except as set forth in Part 2.15(o) of the Company Disclosure
Schedule, each of the Acquired Corporations has good labor relations and the
Company has no Knowledge that (i) the consummation of the Merger or any of the
other transactions contemplated by this Agreement will have a material adverse
effect on the labor relations of any of the Acquired Corporations, or (ii) any
officer or head of facility of any of the Acquired Corporations intends to
terminate his or her employment with such Acquired Corporation.

     2.16   Environmental Matters. Each of the Acquired Corporations is in
compliance in all material respects with all applicable Environmental Laws,
which compliance includes the possession by each of the Acquired Corporations of
all permits and other Governmental Authorizations required under applicable
Environmental Laws, and compliance with the terms and conditions thereof. None
of the Acquired Corporations has received any notice or other communication (in
writing or otherwise), whether from a Governmental Body, citizens group,
employee or otherwise, that alleges that any of the Acquired Corporations are
not in compliance with any Environmental Law, and, to the Knowledge of the
Company, there are no circumstances that may prevent or interfere with the
compliance of the Acquired Corporations with any Environmental Law in the
future. To the Knowledge of the Company, no current or prior owner of any
property leased or controlled by any of the Acquired Corporations has received
any notice or other communication (in writing or otherwise), whether from a
Government Body, citizens group, employee or otherwise, that alleges that such
current or prior owner or any of the Acquired Corporations is not in compliance
with any Environmental Law. All Governmental Authorizations currently held by
the Acquired Corporations pursuant to Environmental Laws are identified in Part
2.16 of the Company Disclosure Schedule. (For purposes of this Section 2.16: (i)
"Environmental Law" means any federal, state, local or foreign Legal Requirement
relating to pollution or protection of human health or the environment
(including ambient air, surface water, ground water, land surface or subsurface
strata), including

                                      27.
<PAGE>

any law or regulation relating to emissions, discharges, releases or threatened
releases of Materials of Environmental Concern, or otherwise relating to the
manufacture, processing, distribution, use, treatment, storage, disposal,
transport or handling of Materials of Environmental Concern; and (ii) "Materials
of Environmental Concern" include chemicals, pollutants, contaminants, wastes,
toxic substances, petroleum and petroleum products and any other substance that
is now or hereafter regulated by any Environmental Law or that is otherwise a
danger to health, reproduction or the environment.)

     2.17   Insurance. Part 2.17 of the Company Disclosure Schedule identifies
all insurance policies maintained by, at the expense of or for the benefit of
each of the Acquired Corporations and identifies any material claims made
thereunder since January 1, 1999, and the Company has delivered to Parent
accurate and complete copies of the insurance policies identified on Part 2.17
of the Company Disclosure Schedule. Each of the insurance policies identified in
Part 2.17 of the Company Disclosure Schedule is in full force and effect. Since
December 31, 1999, none of the Acquired Corporations has received any notice or
other communication regarding any actual or possible (a) cancellation or
invalidation of any insurance policy, (b) refusal of any coverage or rejection
of any claim under any insurance policy, or (c) material adjustment in the
amount of the premiums payable with respect to any insurance policy.

     2.18   Related Party Transactions. Except as set forth in Part 2.18 of the
Company Disclosure Schedule: (a) no Related Party has, and no Related Party has
at any time since December 31, 1999 had, any direct or indirect interest in any
material asset used in or otherwise relating to the business of any of the
Acquired Corporations; (b) no Related Party is, or has at any time since
December 31, 1999 been, indebted to any of the Acquired Corporations; (c) since
December 31, 1999, no Related Party has entered into, or has had any direct or
indirect financial interest in, any material Contract, transaction or business
dealing involving any of the Acquired Corporations; (d) no Related Party is
competing, or has at any time since December 31, 1999 competed, directly or
indirectly, with any of the Acquired Corporations; and (e) no Related Party has
any claim or right against any of the Acquired Corporations (other than rights
under Company Options and rights to receive compensation for services performed
as an employee of the Company). (For purposes of this Section 2.18, each of the
following shall be deemed to be a "Related Party": (i) each individual who is,
or who has at any time since December 31, 1999 been, an officer of any of the
Acquired Corporations; (ii) each member of the immediate family of each of the
individuals referred to in clause "(i)" above; and (iii) any trust or other
Entity (other than the Acquired Corporations) in which any one of the
individuals referred to in clauses "(i)" or "(ii)" above holds (or in which more
than one of such individuals collectively hold), beneficially or otherwise, a
material voting, proprietary or equity interest.)

     2.19   Legal Proceedings; Orders.

            (a) Except as set forth in Part 2.19 of the Company Disclosure
Schedule, there is no pending Legal Proceeding, and (to the Knowledge of the
Company) no Person has threatened to commence any Legal Proceeding: (i) that
involves any of the Acquired Corporations or any of the assets owned or used by
any of the Acquired Corporations or any Person whose liability the Acquired
Corporations has or may have retained or assumed, either contractually or by
operation of law; or (ii) that challenges, or that may have the effect of
preventing, delaying, making illegal or otherwise interfering with, the Merger
or any of the other

                                      28.
<PAGE>

transactions contemplated by this Agreement. To the Knowledge of the Company,
except as set forth in Part 2.19 of the Company Disclosure Schedule, no event
has occurred, and no claim, dispute or other condition or circumstance exists,
that will, or that could reasonably be expected to, give rise to or serve as a
basis for the commencement of any such Legal Proceeding.

            (b) Except as set forth in Part 2.19 of the Company Disclosure
Schedule, no Legal Proceeding has ever been commenced by or has ever been
pending against any of the Acquired Corporations.

            (c) There is no order, writ, injunction, judgment or decree to which
any of the Acquired Corporations, or any of the assets owned or used by any of
the Acquired Corporations, are subject. To the Knowledge of the Company, no
officer or other employee of any of the Acquired Corporations is subject to any
order, writ, injunction, judgment or decree that prohibits such officer or other
employee from engaging in or continuing any conduct, activity or practice
relating to the business of any of the Acquired Corporations.

     2.20   Authority; Binding Nature of Agreement. The Company has the absolute
and unrestricted right, power and authority to enter into and to perform its
obligations under this Agreement; and the execution, delivery and performance by
the Company of this Agreement have been duly authorized by all necessary action
on the part of the Company and its board of directors. This Agreement
constitutes the legal, valid and binding obligation of the Company, enforceable
against the Company in accordance with its terms, subject to (i) laws of general
application relating to bankruptcy, insolvency and the relief of debtors, and
(ii) rules of law governing specific performance, injunctive relief and other
equitable remedies.

     2.21   Non-Contravention; Consents. Except as set forth in Part 2.21 of the
Company Disclosure Schedule, neither (1) the execution, delivery or performance
of this Agreement or any of the other agreements referred to in this Agreement,
nor (2) the consummation of the Merger or any of the other transactions
contemplated by this Agreement, will directly or indirectly (with or without
notice or lapse of time):

            (a) contravene, conflict with or result in a violation of (i) any of
     the provisions of the certificate of incorporation, bylaws or other charter
     or similar organizational documents of any of the Acquired Corporations, or
     (ii) any resolution adopted by the stockholders, the board of directors or
     any committee of the board of directors of any of the Acquired
     Corporations;

            (b) contravene, conflict with or result in a violation of, or give
     any Governmental Body or other Person the right to challenge any of the
     transactions contemplated by this Agreement or to exercise any remedy or
     obtain any relief under, any Legal Requirement or any order, writ,
     injunction, judgment or decree to which any of the Acquired Corporations,
     or any of the assets owned or used by any of the Acquired Corporations, is
     subject;

            (c) contravene, conflict with or result in a violation of any of the
     terms or requirements of, or give any Governmental Body the right to
     revoke, withdraw, suspend, cancel, terminate or modify, any Governmental
     Authorization that is held by any of the

                                      29.
<PAGE>

     Acquired Corporations or that otherwise relates to the business or to any
     of the assets owned or used by any of the Acquired Corporations;

            (d) contravene, conflict with or result in a violation or breach of,
     or result in a default under, any provision of any Acquired Corporation
     Contract that is or would constitute a Material Contract, or give any
     Person the right to (i) declare a default or exercise any remedy under any
     such Material Contract, (ii) accelerate the maturity or performance of any
     such Material Contract, or (iii) cancel, terminate or modify any such
     Material Contract; or

            (e) result in the imposition or creation of any lien or other
     Encumbrance upon or with respect to any asset owned or used by any of the
     Acquired Corporations (except for Permitted Encumbrances).

Except as set forth in Part 2.21 of the Company Disclosure Schedule, none of the
Acquired Corporations was, is or will be required to make any filing with or
give any notice to, or to obtain any Consent from, any Person in connection with
(x) the execution, delivery or performance of this Agreement or any of the other
agreements referred to in this Agreement, or (y) the consummation of the Merger
or any of the other transactions contemplated by this Agreement.

     2.22   Inapplicability of Section 2115 of California Corporations Code. The
Company is not subject to Section 2115 of the California Corporations Code.

     2.23   Vote Required. The affirmative vote of holders of at least (i) a
majority of the outstanding shares of the Company Common Stock and the Company
Series A Preferred Stock, voting together as a single class, and (ii) a majority
of the outstanding shares of the Company Series A Preferred Stock, voting as a
separate class (the "Required Vote") is the vote necessary to adopt and approve
this Agreement, the Merger and the other transactions contemplated by this
Agreement.

     2.24   Brokers or Finders. Except for the fees, costs and expenses payable
to the Company Financial Advisor and incurred in connection with the
transactions contemplated by this Agreement, the Acquired Corporations have not
incurred, and will not incur, directly or indirectly, any liability for
brokerage or finders' fees or agents' commissions or any similar charges in
connection with the transactions contemplated by this Agreement.

     2.25   Full Disclosure.

            (a) No representation or warranty made by the Company in this
Agreement (including the Company Disclosure Schedule) (i) contains any
information that is false or misleading with respect to any material fact, or
(ii) omits to state any material fact necessary in order to make such
representations and warranties (in the light of the circumstances under which
such representations, warranties were made) false or misleading.

            (b) The information supplied by the Company for inclusion in the
Information Statement (as defined in Section 5.2) will not, as of the date of
the Information Statement or as of the date of the Company Stockholders' Meeting
(as defined in Section 5.3), (i) contain any

                                      30.
<PAGE>

statement that is inaccurate or misleading with respect to any material fact, or
(ii) omit to state any material fact necessary in order to make such information
(in the light of the circumstances under which it is provided) not false or
misleading.

SECTION 3.  REPRESENTATIONS AND WARRANTIES OF PARENT AND MERGER SUB

            Except as otherwise set forth in the Parent Disclosure Schedule,
Parent and Merger Sub jointly and severally represent and warrant to the Company
as follows:

     3.1    Organization and Standing; Articles and Bylaws. Each of Parent and
Merger Sub is a corporation duly organized and validly existing under, and by
virtue of, the laws of the State of Delaware and is in good standing under such
laws. Each of Parent and Merger Sub has all requisite corporate power to own and
operate its respective properties and assets, and to carry on its respective
business as presently conducted and as proposed to be conducted. Each of Parent
and Merger Sub is qualified to do business as a foreign corporation in any
jurisdiction in which failure to qualify would have a material adverse effect on
Parent's business. Parent has furnished the Company true and complete copies of
its restated certificate of incorporation (the "Restated Certificate") and
bylaws in effect as of the date hereof. Other than Merger Sub, Parent has no
Subsidiaries and does not otherwise own or control any other Entity. Parent has
no equity interest in any Entity other than Merger Sub.

     3.2    Capitalization. As of the date of this Agreement, the authorized
capital stock of Parent consists of 40,000,000 shares of Parent Common Stock,
4,721,364 shares of which are issued and outstanding, and 22,000,000 shares of
Preferred Stock, 8,283,000 shares of which are designated as Series A Preferred
Stock, all of which are issued and outstanding, 7,099,006 shares of which are
designated Series B Preferred Stock, all of which are issued and outstanding,
5,500,000 of which are designated as Series C Preferred Stock, 1,644,076 of
which are issued and outstanding. All such issued and outstanding shares have
been duly authorized and validly issued, and are fully paid and non-assessable
and have been issued in compliance with all federal and applicable state
securities laws. Parent has reserved 8,283,000 shares of Parent Common Stock for
issuance upon conversion of its Series A Preferred, 7,099,006 shares of Parent
Common Stock for issuance upon conversion of its Series B Preferred, 5,500,000
shares of Parent Common Stock for issuance upon conversion of its Series C
Preferred, 5,000,000 shares of Parent Common Stock for issuance upon conversion
of the Parent Series D Preferred Stock, 650,000 shares of Parent Common Stock
for issuance upon conversion of outstanding options granted outside Parent's
2000 Equity Incentive Plan (the "Parent Stock Plan"), and 5,257,136 shares of
Parent Common Stock for issuance to officers, directors, employees, sales
representatives and consultants of Parent pursuant to the Parent Stock Plan, of
which 3,687,395 shares are currently subject to outstanding options and
1,569,741 shares are available for future issuance. The Parent Common Stock and
the Parent Series D Preferred Stock, when the Amended and Restated Certificate
of Parent attached hereto as Exhibit D (the "Parent Amended and Restated
Certificate") is filed, shall have the rights, preferences, privileges and
restrictions set forth in the Parent Amended and Restated Certificate. There are
no options, warrants (other than warrants to purchase 10,000 shares of Parent
Common Stock and warrants to purchase 254,000 shares of Parent Series B
Preferred Stock), conversion privileges or other rights presently outstanding to
purchase or otherwise acquire any authorized but unissued shares of the capital
stock or other securities of Parent, nor any agreements or understandings with
respect

                                      31.
<PAGE>

thereto. Parent is not a party or subject to any agreement or understanding,
and, to Parent's Knowledge, there is no agreement or understanding between any
Persons, which affects or relates to the voting or giving of consents with
respect to any security or by a director of Parent. Parent is not under any
obligation to register any of its presently outstanding securities or any of its
securities that may hereafter be issued. To Parent's Knowledge, no stockholders
of Parent have entered into any agreements with respect to the voting of capital
stock of Parent.

     3.3    Financial Statements.

            (a) Parent has delivered to the Company the following financial
statements and notes (collectively, the "Parent Financial Statements"):

                (i)  The audited balance sheets of Parent as of December 31,
         1999, and the related audited income statements, statements of
         stockholders' equity and statements of cash flows of Parent for the
         years then ended, together with the notes thereto and the unqualified
         report and opinion of Ernst & Young LLP relating thereto; and

                (ii) the unaudited balance sheet of Parent as of September 30,
         2000 (the "Unaudited Interim Balance Sheet"), and the related unaudited
         income statement of Parent for the nine months then ended.

            (b) The Parent Financial Statements are accurate and complete in all
material respects and present fairly the financial position of Parent as of the
respective dates thereof and the results of operations and (in the case of the
financial statements referred to in Section 3.5(a)(i)) cash flows of Parent for
the periods covered thereby. The Parent Financial Statements have been prepared
in accordance with generally accepted accounting principles applied on a
consistent basis throughout the periods covered (except that the financial
statements referred to in Section 3.5(a)(ii) do not contain footnotes and are
subject to normal and recurring year-end audit adjustments, which will not,
individually or in the aggregate, be material in magnitude).

            (c) Except as set forth in the Parent Financial Statements, Parent
has no material liabilities, contingent or otherwise, other than (i) liabilities
incurred in the ordinary course of business subsequent to September 30, 2000 and
(ii) obligations under contracts and commitments incurred in the ordinary course
of business and not required under generally accepted accounting principles to
be reflected in the Parent Financial Statements, which, in both cases,
individually or in the aggregate are not material to the financial condition or
operating results of Parent.

     3.4    Actions. Parent has not (i) declared or paid any dividends, or
authorized or made any distribution upon or with respect to any class or series
of its capital stock, (ii) except as may be contemplated by this Agreement,
incurred any indebtedness for money borrowed or incurred any other liabilities
individually in excess of $25,000 or in excess of $50,000 in the aggregate,
(iii) made any loans or advances to any person, other than ordinary advances for
travel expenses, or (iv) sold, exchanged or otherwise disposed of any of its
assets or rights, other than the sale of its inventory in the ordinary course of
business.

     3.5    Title to Properties and Assets; Liens, etc. Parent has good and
marketable title to all its properties and assets, and is in compliance with the
lease of all material properties

                                      32.
<PAGE>

leased by it, in each case subject to no Encumbrances, other than liens for
current taxes not yet due and payable. Parent is not in default under or in
breach of any provision of its leases, and Parent holds valid lease-hold
interests in the properties which it leases. Parent's material properties and
assets are in good condition and repair, ordinary wear and tear excepted, in all
material respects.

     3.6    Patents, Trademarks, etc. To the Knowledge of Parent, Parent has
sufficient title and ownership of all patents, trademarks, service marks, trade
names, copyrights, trade secrets, information, proprietary rights and processes
necessary for its business as now conducted, and as proposed to be conducted,
and, to the Knowledge of Parent, without conflict with or infringement of the
rights of others. Parent has not received any communications alleging that
Parent has violated or, by conducting its business as proposed, would violate,
the patents, trademarks, service marks, trade names, copyrights, trade secrets,
information or proprietary or intellectual property rights of any other person
or entity. Parent has no Knowledge of any violation or infringement by a third
party of any of Parent's patents, licenses, trademarks, service marks, trade
names, copyrights, trade secrets or other proprietary rights. Parent has
disclosed trade secrets to other persons solely as required for the conduct of
its business and solely under nondisclosure agreements that are enforceable by
Parent. Parent has at all times maintained reasonable procedures to protect and
have enforced all of its trade secrets.

     3.7    Proprietary Information and Inventions Agreements. Each employee,
consultant and officer of Parent has executed an agreement with Parent regarding
confidentiality and proprietary information substantially in the form or forms
delivered to the counsel for the Company. Parent, after reasonable
investigation, is not aware that any of its employees or consultants is in
violation thereof. All consultants to or vendors of Parent with access to
confidential information of Parent are parties to a written agreement
substantially in the form or forms provided to counsel for the Company under
which, among other things, each such consultant or vendor is obligated to
maintain the confidentiality of confidential information of Parent. Parent,
after reasonable investigation, has no Knowledge that any of its consultants or
vendors are in violation thereof.

     3.8    Material Contracts and Commitments. Part 3.8 of the Parent
Disclosure Schedule sets forth a list of all Contracts to which Parent is a
party or by which it or its assets are bound that (a) involve in excess of
$50,000 aggregating similar agreements or obligations to the same party; (b)
involve to Parent's Knowledge any of the officers, consultants, directors,
employees, or shareholders of Parent or any members of the immediate family of
the foregoing; or (c) obligate Parent to share, license, or develop any product.
True and complete copies of all items set forth on Part 3.8 of the Parent
Disclosure Schedule have been made available to the Major Stockholders.

     3.9   Compliance with Other Instruments. Neither Parent nor Merger Sub is
in violation of any term of its respective certificate of incorporation (as
amended) or its respective bylaws (as amended), or in any material respect of
any term or provision of any mortgage, indenture, Contract, judgment or decree,
and to the Parent's Knowledge, neither Parent nor Merger Sub is in violation of
any order, statute, rule or regulation applicable to Parent. The execution,
delivery and performance of and compliance with this Agreement and each of the
other Transaction Agreements, have not resulted and will not result in any
violation of, or

                                      33.
<PAGE>

conflict with, or constitute a default under any of the foregoing, or result in
the creation of any mortgage, pledge, lien, encumbrance or charge upon any of
the properties or assets of Parent; and there is no such violation or default
which materially and adversely affects the business, financial condition or
results of operations of Parent or any of its properties or assets. All of the
Contracts set forth on Part 3.8 of the Parent Disclosure Schedule are in full
force and effect and constitute legal, valid and binding obligations of Parent.
Parent and, to the Knowledge of Parent, each other party thereto, has performed
in all material respects all obligations required to be performed by it under
the Contracts set forth on Part 3.8 of the Parent Disclosure Schedule, and no
material violation or default exists in respect thereof, nor any event that with
notice or lapse of time, or both, would constitute a default thereof; on the
part of Parent or, to the Knowledge of Parent, any other party thereto; none of
the Contracts set forth on Part 3.8 of the Parent Disclosure Schedule is
currently being renegotiated; and the validity, effectiveness and continuation
of all Contracts set forth on Part 3.8 of the Parent Disclosure Schedule will
not be materially adversely affected by the transactions contemplated by this
Agreement or any of the other Transaction Agreements.

     3.10   Validity of Parent Capital Stock. The Parent Capital Stock, when
issued in compliance with the provisions of this Agreement, will be duly and
validly issued and will be fully paid and nonassessable and free and clear of
all Encumbrances, and the Parent Common Stock issuable upon conversion of the
Parent Series D Preferred Stock will, prior to the Closing, be duly and validly
reserved and, when issued and delivered in compliance with the provisions of the
Amended and Restated Certificate will be duly and validly issued and will be
fully paid and nonassessable and free and clear of all Encumbrances on transfer
other than as set forth in this Agreement and the other Transaction Agreements,
provided, however, that the Parent Capital Stock (and the Parent Common Stock
issuable upon conversion of the Parent Series D Preferred Stock) may be subject
to restrictions on transfer under state and/or federal securities laws. There
are no outstanding rights of first refusal or preemptive rights applicable to
the Parent Capital Stock.

     3.11   Governmental Authorizations. Parent has all Governmental
Authorizations necessary to enable Parent to conduct its business in the manner
in which its business is currently being conducted. Parent is, and at all times
since December 31, 1999 has been, in substantial compliance with the terms and
requirements of all material Governmental Authorizations held by Parent. Since
December 31, 1999, Parent has not received any notice or other communication
from any Governmental Body regarding (a) any actual or possible violation of or
failure to comply with any term or requirement of any Governmental
Authorization, or (b) any actual or possible revocation, withdrawal, suspension,
cancellation, termination or modification of any Governmental Authorization.

     3.12   Tax Returns and Payments. Parent has filed all tax returns and
reports as required by law. These returns and reports are true and correct in
all material respects. Parent has paid all taxes and other assessments due.

     3.13   Tax Elections. Parent has not elected pursuant to the Internal
Revenue Code of 1986, as amended (the "Code"), to be treated as an "S"
corporation or a collapsible corporation pursuant to Section 341(f) or Section
1362(a) of the Code, nor has it made any other elections pursuant to the Code
(other than elections which relate solely to matters of accounting,

                                      34.
<PAGE>

depreciation or amortization) which would have a material affect on Parent, its
financial condition, its business as presently conducted or as presently
proposed to be conducted or any of its properties or material assets.

     3.14   Employees. To Parent's Knowledge, no employee of Parent is or will
be in violation of any judgment, decree or order of any court or administrative
agency, or any term of any employment contract or any other contract (including
without limitation any covenant not to compete) or agreement relating to the
relationship of any such employee with Parent or any other party because of the
nature of the business conducted or to be conducted by Parent or to the
utilization by the employee of such employee's reasonable efforts with respect
to such business. Parent does not have any collective bargaining agreements
covering any of its employees. To Parent's Knowledge, Parent is not using any
inventions of any of its employees, consultants or officers made before their
employment by Parent. To Parent's Knowledge, no employee, consultant or officer
has taken, removed, or made use of any proprietary documentation, manuals,
products, materials, or any other tangible items from the employee's previous
employers relating to Parent's business. To Parent's Knowledge, no labor union
has sought to represent any of the employees of Parent. There is no strike or
other labor dispute involving Parent pending, or to the Knowledge of Parent,
threatened. To Parent's Knowledge, no officer or key employee intends to
terminate his or her employment with Parent.

     3.15   Employee Benefit Plans. Neither Parent nor Merger Sub has any
Employee Benefit Plan as defined in ERISA.

     3.16   Environmental Matters. The business, assets and properties of Parent
are and have been operated and maintained in material compliance with all
applicable Environmental Laws. To Parent's Knowledge, no event has occurred
which, with or without the passage of time or the giving of notice, or both,
would constitute noncompliance by Parent with, or a violation by Parent of, the
Environmental Laws. To Parent's Knowledge, Parent has not caused or permitted to
exist, as a result of an intentional or unintentional act or omission, a
disposal, discharge or release of solid wastes, pollutants or hazardous
substances, on or from any site which currently is or formerly was owned,
leased, occupied or used by it, except where such disposal, discharge or release
was in material compliance with the Environmental Laws.

     3.17   Insurance. Parent has in full force and effect fire, casualty and
liability insurance policies with recognized insurers with such coverages as are
sufficient in amount to allow replacement of the tangible properties of Parent
that might be damaged or destroyed.

     3.18   No Conflict of Interest. Parent is not indebted, directly or
indirectly, to any of its officers or directors or to their respective spouses
or children, in any amount whatsoever other than in connection with expenses or
advances of expenses incurred in the ordinary course of business or relocation
expenses of employees. To Parent's Knowledge, none of Parent's officers or
directors, or any members of their immediate families, are, directly or
indirectly, indebted to Parent (other than in connection with purchases of
Parent's stock) or have any direct or indirect ownership interest in any firm or
corporation with which Parent is affiliated or with which Parent has a business
relationship, or any firm or corporation which competes with Parent, except that
officers, directors and/or shareholders of Parent may own stock in (but not
exceeding two percent of the outstanding capital stock of) any publicly traded
company that may compete with

                                      35.
<PAGE>

Parent. To Parent's Knowledge, none of Parent's officers or directors or any
members of the immediate families are, directly or indirectly, interested in any
material contract with Parent. Parent is not a guarantor or indemnitor of any
indebtedness of any other Person.

     3.19   Litigation, etc. There are no actions, suits, proceedings or
investigations pending or, to Parent's Knowledge, threatened against Parent or
its properties before any Governmental Body, which, either in any case or in the
aggregate, might result in any material adverse effect on the business,
financial condition, affairs, operations or equity ownership of Parent or any of
its properties or assets, or in any material impairment of the right or ability
of Parent to carry on its business as now conducted or as presently proposed to
be conducted, or in any material liability on the part of Parent, and none which
questions the validity of this Agreement or any of the other Transaction
Agreements or any action taken or to be taken in connection herewith or
therewith. Parent is not a party or subject to the order, writ, judgement,
injunction, decree or other provisions of any Governmental Body. There is no
action, suit, proceeding, or investigation by Parent currently pending or that
Parent intends to initiate.

     3.20   Authority; Binding Nature of Agreement. Parent and Merger Sub each
has the absolute and unrestricted right, power and authority to enter into and
to perform its respective obligations under this Agreement, the Escrow
Agreements, the Voting Agreements, and the Noncompetition Agreements
(collectively, the "Transaction Agreements"); and the execution, delivery and
performance by Parent and Merger Sub of the Transaction Agreements have been
duly authorized by all necessary action on the part of the Parent and Merger
Sub. This Agreement and each of the other Transaction Agreements to which either
Parent or Merger Sub is a party constitutes the legal, valid and binding
obligation of Parent and/or Merger Sub, as the case may be, enforceable against
Parent and/or Merger Sub, as the case may be, in accordance with their
respective terms, subject to (i) laws of general application relating to
bankruptcy, insolvency and the relief of debtors, and (ii) rules of law
governing specific performance, injunctive relief and other equitable remedies.

     3.21   Non-Contravention; Consents. Neither the execution and delivery of
this Agreement by Parent and Merger Sub nor the consummation by Parent and
Merger Sub of the Merger will (a) conflict with or result in any breach of any
provision of the certificate of incorporation or bylaws of Parent or Merger Sub,
(b) result in a default by Parent or Merger Sub under any Contract to which
Parent or Merger Sub is a party, except for any default that has not had and
will not have a Material Adverse Effect on Parent, or (c) result in a violation
by Parent or Merger Sub of any order, writ, injunction, judgment or decree to
which Parent or Merger Sub is subject, except for any violation that has not had
and will not have a Material Adverse Effect on Parent. Except as may be required
by the Securities Act, state securities or "blue sky" laws, the DGCL, the HSR
Act, any foreign antitrust law or regulation, Parent is not and will not be
required to make any filing with or give any notice to, or to obtain any Consent
from, any Person in connection with the execution, delivery or performance of
this Agreement or the consummation of the Merger.

     3.22   Financial Condition. Parent was incorporated on May 11, 1998. Since
that time, Parent has only engaged in startup and development activities and has
generated no revenue. Since inception, Parent has been operated only in the
ordinary course of business, and there has not been a Material Adverse Effect on
Parent.

                                      36.
<PAGE>

     3.23

     3.24   U.S. Real Property Holding Corporation. Parent is not now, nor will
it be immediately after the Closing, a "United States Real Property Holding
Corporation" as defined in Section 897(c)(2) of the Code and Section 1.897-2(b)
of the regulations promulgated under the Code.

     3.25   Investment Company Act. Parent is not an "investment company" nor is
Parent directly or indirectly controlled by or acting on behalf of any person
which is an "Investment Company" within the meaning of the Investment Company
Act of 1940, as amended.

     3.26   No Brokers or Finders. Parent has not incurred, and will not incur,
directly or indirectly, any liability for brokerage or finders' fees or agents'
commissions or any similar charges in connection with the transactions
contemplated by this Agreement.

     3.27   Full Disclosure.

            (a)  No representation or warranty made by Parent or Merger Sub in
this Agreement (including the Parent Disclosure Schedule) (i) contains any
information that is false or misleading with respect to any material fact, or
(ii) omits to state any material fact necessary in order to make such
representations and warranties (in the light of the circumstances under which
such representations, warranties were made) false or misleading.

            (b)  The information supplied by Parent or Merger Sub for inclusion
in the Information Statement (as defined in Section 5.2) will not, as of the
date of the Information Statement or as of the date of the Company Stockholders'
Meeting (as defined in Section 5.3), (i) contain any statement that is
inaccurate or misleading with respect to any material fact, or (ii) omit to
state any material fact necessary in order to make such information (in the
light of the circumstances under which it is provided) not false or misleading.

SECTION 4.  CERTAIN COVENANTS OF THE PARTIES

     4.1    Access and Investigation. During the period from the date of this
Agreement through the Effective Time (the "Pre-Closing Period"), the Company
shall, and shall cause its Representatives to: (a) provide Parent and Parent's
Representatives with reasonable access to the Acquired Corporations'
Representatives, personnel and assets and to all existing books, records, Tax
Returns, work papers and other documents and information relating to the
Company; and (b) provide Parent and Parent's Representatives with copies of such
existing books, records, Tax Returns, work papers and other documents and
information relating to the Acquired Corporations, and with such additional
financial, operating and other data and information regarding the Acquired
Corporations, as Parent may reasonably request.

     4.2    Operation of the Company's Business. During the Pre-Closing Period:

            (a)  the Company shall (and shall cause each of the other Acquired
     Corporations to) conduct their respective businesses and operations in the
     ordinary course and in substantially the same manner as such businesses and
     operations have been conducted prior to the date of this Agreement;

                                      37.
<PAGE>

            (b)  the Company shall (and shall cause each of the other Acquired
     Corporations to) use reasonable efforts to preserve intact their respective
     current business organizations, keep available the services of their
     respective current officers and employees and maintain their respective
     relations and good will with all suppliers, customers, landlords,
     creditors, employees and other Persons having business relationships with
     any of the Acquired Corporations;

            (c)  the Company shall (and shall cause each of the other Acquired
     Corporations to) keep in full force all insurance policies identified in
     Part 2.17 of the Company Disclosure Schedule;

            (d)  the Company shall (and shall cause each of the other Acquired
     Corporations to) cause their respective officers to report regularly (but
     in no event less frequently than bi-monthly) to Parent concerning the
     status of the business of each Acquired Corporation;

            (e)  the Company shall use commercially reasonable efforts to file
     an amended and restated certificate of incorporation with the Secretary of
     State for the State of Delaware that provides for a liquidation preference
     in favor of the Company Series A Preferred Stock equal in value, in the
     aggregate, to the Liquidation Consideration (the "Company Amended and
     Restated Certificate");

            (f)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) declare, accrue, set aside or pay any
     dividend or make any other distribution in respect of any shares of capital
     stock, and shall not repurchase, redeem or otherwise reacquire any shares
     of capital stock or other securities (except that the Company may
     repurchase Company Common Stock from former employees pursuant to the terms
     of existing restricted stock purchase agreements);

            (g)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) sell, issue or authorize the issuance of (i)
     any capital stock or other security, (ii) any option or right to acquire
     any capital stock or other security, or (iii) any instrument convertible
     into or exchangeable for any capital stock or other security (except that
     the Company shall be permitted (y) to issue Company Common Stock to
     employees upon the exercise of outstanding Company Options, and (z) to
     issue shares of Company Common Stock upon the conversion of shares of
     Company Preferred Stock);

            (h)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) amend or waive any of its rights under, or
     permit the acceleration of vesting under, (i) any provision of the Stock
     Plan, (ii) any provision of any agreement evidencing any outstanding
     Company Option, or (iii) any provision of any restricted stock purchase
     agreement;

            (i)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) amend or permit the adoption of any amendment
     to the Company's Certificate of Incorporation or Bylaws or similar
     organizational documents of any Acquired Corporation, or effect or permit
     any Acquired Corporation to become a party to

                                      38.
<PAGE>

     any Acquisition Transaction, recapitalization, reclassification of shares,
     stock split, reverse stock split or similar transaction (except that the
     Company may issue shares of Company Common Stock upon the conversion of
     shares of Company Series A Preferred Stock);

            (j)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) form any subsidiary or acquire any equity
     interest or other interest in any other Entity;

            (k)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) make any capital expenditure, except for
     capital expenditures that, when added to all other capital expenditures
     made on behalf of the Acquired Corporations during the Pre-Closing Period,
     do not exceed $15,000 per month;

            (l)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) (i) enter into, or permit any of the assets
     owned or used by any Acquired Corporation to become bound by, any Contract
     that is or would constitute a Material Contract, or (ii) amend or
     prematurely terminate, or waive any material right or remedy under, any
     such Contract (except amendment or termination of the Company's existing
     line of credit with that certain Loan Agreement dated February 1, 1999
     among First Union National Bank (the "Bank"), the Company and PPD (the
     "Company Line of Credit");

            (m)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) (i) acquire, lease or license any right or
     other asset from any other Person, (ii) sell or otherwise dispose of, or
     lease or license, any right or other asset to any other Person, or (iii)
     waive or relinquish any right, except for assets acquired, leased, licensed
     or disposed of by the Company pursuant to Contracts that are not Material
     Contracts;

            (n)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) (i) lend money to any Person (except that the
     Company may make routine travel advances to employees in the ordinary
     course of business and may, consistent with its past practices, allow
     employees to acquire Company Common Stock in exchange for promissory notes
     upon exercise of Company Options), or (ii) incur or guarantee any
     indebtedness for borrowed money (except that the Company may make routine
     borrowings in the ordinary course of business under the Company Line of
     Credit or that certain Loan Agreement dated September 22, 2000 among the
     Company and the Major Stockholders (the "Loan Agreement"));

            (o)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) (i) establish, adopt or amend any Employee
     Benefit Plan, (ii) pay any bonus or make any profit-sharing payment, cash
     incentive payment or similar payment to, or increase the amount of the
     wages, salary, commissions, fringe benefits or other compensation or
     remuneration payable to, any of its directors, officers or employees, or
     (iii) hire any new employee whose aggregate annual compensation is expected
     to exceed $50,000;

                                      39.
<PAGE>

            (p)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) change any methods of accounting or
     accounting practices of any Acquired Corporation in any material respect;

            (q)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) make any Tax election;

            (r)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) commence or settle any material Legal
     Proceeding;

            (s)  the Company shall not (and shall cause each of the other
     Acquired Corporations not to) agree or commit to take any of the actions
     described in clauses "(f)" through "(f)" above.

Notwithstanding the foregoing, the Company may take any action described in
clauses "(f)" through "(s)" above if Parent gives its prior written consent to
the taking of such action by the Company, which consent will not be unreasonably
withheld (it being understood that Parent's withholding of consent to any action
will not be deemed unreasonable if Parent determines in good faith that the
taking of such action would not be in the best interests of Parent or would not
be in the best interests of the Company); provided, however, that Parent's
consent shall be deemed to have been granted if Parent fails to reply to a
written request from the Company to take any action described in clauses "(e)"
through "(r)" above within five days after receipt of such written request.

     4.3    Notification; Updates to Company Disclosure Schedule.

            (a)  During the Pre-Closing Period, the Company shall promptly
     notify Parent in writing of:

                 (i)    the discovery by any Acquired Corporation of any event,
     condition, fact or circumstance that occurred or existed on or prior to the
     date of this Agreement and that caused or constitutes an inaccuracy in or
     breach of any representation or warranty made by the Company in this
     Agreement;

                 (ii)   any event, condition, fact or circumstance that occurs,
     arises or exists after the date of this Agreement and that would cause or
     constitute an inaccuracy in or breach of any representation or warranty
     made by the Company in this Agreement if (A) such representation or
     warranty had been made as of the time of the occurrence, existence or
     discovery of such event, condition, fact or circumstance, or (B) such
     event, condition, fact or circumstance had occurred, arisen or existed on
     or prior to the date of this Agreement;

                 (iii)  any breach of any covenant or obligation of the Company;
     and

                 (iv)   any event, condition, fact or circumstance that would
     make the timely satisfaction of any of the conditions set forth in Section
     6 or Section 7 impossible or unlikely.

                                      40.
<PAGE>

          (b)  If any event, condition, fact or circumstance that is required to
be disclosed pursuant to Section 4.3(a) requires any change in the Company
Disclosure Schedule, or if any such event, condition, fact or circumstance would
require such a change assuming the Company Disclosure Schedule were dated as of
the date of the occurrence, existence or discovery of such event, condition,
fact or circumstance, then the Company shall promptly deliver to Parent an
update to the Company Disclosure Schedule specifying such change. No such update
shall be deemed to supplement or amend the Company Disclosure Schedule for the
purpose of (i) except as set forth in Section 9.2(a), determining the accuracy
of any of the representations and warranties made by the Company in this
Agreement, or (ii) determining whether any of the conditions set forth in
Section 6 has been satisfied.

     4.4  Notification; Updates to Parent Disclosure Schedule.

          (a)   During the Pre-Closing Period, Parent shall promptly notify the
Company in writing of:

                (i)    the discovery by Parent of any event, condition, fact or
     circumstance that occurred or existed on or prior to the date of this
     Agreement and that caused or constitutes an inaccuracy in or breach of any
     representation or warranty made by Parent and Merger Sub in this Agreement;

                (ii)   any event, condition, fact or circumstance that occurs,
     arises or exists after the date of this Agreement and that would cause or
     constitute an inaccuracy in or breach of any representation or warranty
     made by Parent and Merger Sub in this Agreement if (A) such representation
     or warranty had been made as of the time of the occurrence, existence or
     discovery of such event, condition, fact or circumstance, or (B) such
     event, condition, fact or circumstance had occurred, arisen or existed on
     or prior to the date of this Agreement;

                (iii)  any breach of any covenant or obligation of Parent or
     Merger Sub; and

                (iv)   event, condition, fact or circumstance that would make
     the timely satisfaction of any of the conditions set forth in Section 6 or
     Section 7 impossible or unlikely.

     If any event, condition, fact or circumstance that is required to be
disclosed pursuant to Section 4.4(a) requires any change in the Parent
Disclosure Schedule, or if any such event, condition, fact or circumstance would
require such a change assuming the Parent Disclosure Schedule were dated as of
the date of the occurrence, existence or discovery of such event, condition,
fact or circumstance, then Parent shall promptly deliver to the Company an
update to the Parent Disclosure Schedule specifying such change. No such update
shall be deemed to supplement or amend the Parent Disclosure Schedule for the
purpose of (i) except as set forth in Section 9.2(b), determining the accuracy
of any of the representations and warranties made by Parent and Merger Sub in
this Agreement, or (ii) determining whether any of the conditions set forth in
Section 7 has been satisfied.

     4.5  Operation of Parent's Business.  During the Pre-Closing Period:

                                      41.
<PAGE>

          (a)  Parent shall (and shall cause each of its Subsidiaries to)
     conduct their respective businesses and operations in the ordinary course
     and in substantially the same manner as such businesses and operations have
     been conducted prior to the date of this Agreement (it being understood,
     however, that Parent may continue preparations for the initial public
     offering of Parent Common Stock);

          (b)  Parent shall (and shall cause each of its respective Subsidiaries
     to) use reasonable efforts to preserve intact their respective current
     business organizations, keep available the services of their respective
     current officers and employees and maintain their respective relations and
     good will with all suppliers, customers, landlords, creditors, employees
     and other Persons having business relationships with any of Parent and/or
     any of its Subsidiaries;

          (c)  Parent shall use commercially reasonable efforts to file the
     Amended and Restated Certificate as soon as possible;

          (d)  Parent shall use commercially reasonable efforts to ensure that,
     as of immediately after the Closing, PPD will be permitted to appoint one
     member of the board of directors of Parent.

          (e)  Parent shall not declare, accrue, set aside or pay any dividend
     or make any other distribution in respect of any shares of Parent's capital
     stock, and shall not repurchase, redeem or otherwise reacquire any shares
     of Parent's capital stock or other securities (except that Parent may
     repurchase Parent Common Stock from former employees pursuant to the terms
     of existing restricted stock purchase agreements);

          (f)  Parent shall not amend or permit the adoption of any amendment to
     the Restated Certificate or Parent's Bylaws that would have the effect of
     diminishing the rights, preferences or privileges of the Parent Series D
     Preferred Stock as set forth in the Restated Certificate.

Notwithstanding the foregoing, Parent may take any action described in clauses
"(e)" or "(f)" if the Company gives its prior written consent to the taking of
such action by Parent, which consent will not be unreasonably withheld (it being
understood that the Company's withholding of consent to any action will not be
deemed unreasonable if the Company determines in good faith that the taking of
such action would not be in the best interests of the Company); provided,
however, that the Company's consent shall be deemed to have been granted if the
Company fails to reply to a written request from Parent to take any action
described in clauses "(e)" or "(f)" above within five days after receipt of such
written request

     4.6  No Negotiation. During the Pre-Closing Period, the Company shall not
(and shall cause each of the other Acquired Corporations not to), directly or
indirectly:

          (a)  solicit or encourage the initiation of any inquiry, proposal or
     offer from any Person (other than Parent) relating to a possible
     Acquisition Transaction;

                                      42.
<PAGE>

          (b)  participate in any discussions or negotiations or enter into any
     agreement with, or provide any non-public information to, any Person (other
     than Parent) relating to or in connection with a possible Acquisition
     Transaction; or

          (c)  consider, entertain or accept any proposal or offer from any
     Person (other than Parent) relating to a possible Acquisition Transaction.

The Company shall promptly notify Parent in writing of any material inquiry,
proposal or offer relating to a possible Acquisition Transaction that is
received by the Company during the Pre-Closing Period.

SECTION 5.  ADDITIONAL COVENANTS OF THE PARTIES

     5.1  Filings and Consents. As promptly as practicable after the execution
of this Agreement, each party to this Agreement (a) shall make all filings (if
any) and give all notices (if any) required to be made and given by such party
in connection with the Merger and the other transactions contemplated by this
Agreement, and (b) shall use all commercially reasonable efforts to obtain all
Consents (if any) required to be obtained (pursuant to any applicable Legal
Requirement or Contract, or otherwise) by such party in connection with the
Merger and the other transactions contemplated by this Agreement. The Company
shall (upon request) promptly deliver to Parent a copy of each such filing made,
each such notice given and each such Consent obtained by the Company during the
Pre-Closing Period.

     5.2  Company Stockholders' Meeting. As promptly as practicable after the
execution of this Agreement, the Company and Parent shall jointly prepare an
Information Statement relating to the adoption of this Agreement and the
approval of the transactions contemplated hereby by the Company's stockholders
and the exercise of appraisal rights in connection therewith (the "Information
Statement"). The Company shall provide and include in the Information Statement
such information relating to the Company and its stockholders as may be required
pursuant to the provisions of applicable securities and corporate laws
(including, without limitation, Rule 502 under the Securities Act). The Company
shall, in accordance with its Certificate of Incorporation and Bylaws and the
applicable requirements of the Delaware General Corporation Law, call and hold a
special meeting of its stockholders as promptly as practicable, and in any event
no later than December 20, 2000, for the purpose of permitting them to consider
and to vote upon and adopt this Agreement and approve the transactions
contemplated hereby (the "Company Stockholders' Meeting"). The Company shall
cause a copy of the Information Statement to be delivered to each stockholder of
the Company who is entitled to vote on the adoption of this Agreement and
approval of the transactions contemplated hereby. As promptly as practicable
after the delivery of copies of the Information Statement to all stockholders
entitled to vote at the Company Stockholders' Meeting, the Company shall take
all actions necessary (i) to solicit from each of such stockholders a proxy in
favor of the adoption of this Agreement and the approval of the transactions
contemplated hereby and (ii) to cause each of such stockholders to execute and
deliver to Parent a Stockholder Representation Letter in a form to be mutually
agreed upon by the parties hereto. In lieu of calling and holding the Company
Stockholders' Meeting, the Company may solicit written consents (to be effective
on or prior to December 20, 2000) in accordance with its certificate of
incorporation and bylaws and the applicable requirements of the Delaware General
Corporation Law. Parent will reasonably

                                      43.
<PAGE>

cooperate with the Company with respect to the matters set forth in this Section
5.2. Parent will promptly provide all information relating to its business or
operations necessary for inclusion in the Information Statement to satisfy all
requirements of applicable state and federal securities and corporate laws.

     5.3  Public Announcements. During the Pre-Closing Period, (a) Neither
Parent nor the Company shall (and Parent and the Company shall not permit any of
their respective Representatives to, and the Company shall use commercially
reasonable efforts to cause the Major Stockholders to) issue any press release
or make any public statement regarding this Agreement or the Merger, or
regarding any of the other transactions contemplated by this Agreement, without
the prior written consent of the Company or Parent, as the case may be, and (b)
Parent and the Company will use reasonable efforts to consult with one another
(and the Company shall use commercially reasonable efforts to cause the Major
Stockholders to consult with Parent) prior to issuing any press release or
making any public statement regarding the Merger.

     5.4  Reasonable Efforts. During the Pre-Closing Period, (a) the Company
shall use commercially reasonable efforts to cause the conditions set forth in
Section 6 to be satisfied on a timely basis, and (b) Parent and Merger Sub shall
use commercially reasonable efforts to cause the conditions set forth in Section
7 to be satisfied on a timely basis.

     5.5  Tax Matters. Prior to the Closing, Parent, Merger Sub and the Company
shall execute and deliver, to Cooley Godward LLP and to Heller Ehrman White &
McAuliffe LLP, tax representation letters in substantially the form of Exhibit
E. Parent, Merger Sub and the Company shall each confirm to Cooley Godward LLP
and to Heller Ehrman White & McAuliffe LLP the accuracy and completeness as of
the Effective Time and thereafter, where relevant, of the tax representation
letters delivered pursuant to the immediately preceding sentence. Parent and the
Company shall use commercially reasonable efforts prior to the Effective Time to
cause the Merger to qualify as a tax-free reorganization under Section 368(a)(1)
of the Code. Following delivery of the tax representation letters pursuant to
the first sentence of this Section 5.6, each of Parent and the Company shall use
its commercially reasonable efforts to cause Cooley Godward LLP and Heller
Ehrman White & McAuliffe LLP, respectively, to deliver to it a tax opinion
satisfying the requirements of Section 6.5(h) hereof and Section 7.3(b) hereof.
In rendering such opinions, each of such counsel shall be entitled to rely on
the tax representation letters referred to in this Section 5.6. The parties
hereto shall report the Merger as a reorganization within the meaning of Section
368(a) of the Code, and neither Parent, Merger Sub nor the Company shall take
any action prior to or following the Closing that would reasonably be expected
to cause the Merger to fail to qualify as a reorganization.

     5.6  Noncompetition Agreements. The Company shall use commercially
reasonable efforts to cause each of the Major Stockholders to execute and
deliver to Parent prior to the Closing a Noncompetition Agreement in the form of
Exhibit F.

     5.7  Employment Agreements. The Company shall use commercially reasonable
efforts to cause each of the individuals identified on Exhibit G to execute and
deliver to Parent prior to the Closing an Employment Agreement in the form of
Exhibit H.

                                      44.
<PAGE>

     5.8  Releases. The Company shall use commercially reasonable efforts to
cause each of the Company stockholders to execute and deliver to Parent at the
Closing a Release in the form of Exhibit I.

     5.9  Underwriter Lockup Agreements. The Company shall use commercially
reasonable efforts to cause each of the Company stockholders to execute and
deliver to Parent prior to the Closing an Underwriter Lockup Agreement in the
form of Exhibit J.

     5.10 Amendment/Clarification of Existing Agreements; Payoff of Company Line
of Credit.

          (a)  The Company shall execute and deliver, and shall use commercially
reasonable efforts to cause the other parties to such agreements to execute and
deliver: (1) the Amended and Restated Distributor Agreement between the Company
and PPD dated February 1, 1999, as amended attached hereto as Exhibit K; and (2)
the Amended and Restated Technology Transfer and License Agreement between the
Company and Axys dated February 1, 1999, as amended attached hereto as Exhibit
L. The Company shall execute and deliver, and shall use commercially reasonable
efforts to cause PPD to execute and deliver, (1) the clarification letter to the
PPD/PPGx Joint Development Agreement attached hereto as Exhibit M and (2) the
real property indemnity letter attached hereto as Exhibit N. The Company shall
execute and deliver, and shall use commercially reasonable efforts to cause Axys
to execute and deliver, (1) the covenant not to sue agreement attached hereto as
Exhibit O and (2) the assignment letter attached hereto as Exhibit P.

          (b)  Parent shall use commercially reasonable efforts to execute and
deliver (and the Company shall use commercially reasonable efforts to cause the
Major Stockholders to execute and deliver): (1) that certain Amended and
Restated Investor Rights Agreement attached hereto as Exhibit Q; and (2) that
certain Co-Sale Agreement attached hereto as Exhibit R.

          (c)  The Company shall use commercially reasonable efforts to cause
the Company's indebtedness existing as of immediately prior to the Closing to
the Bank to be repaid and the indebtedness due and payable to the Major
Stockholders under the Loan Agreement to be contributed to the capital of the
Company.

     5.11 Termination of Certain Agreements.

          (a)  The Company shall use commercially reasonable efforts to ensure
that the Investor Rights Agreement of the Company dated February 1, 1999 and the
Registration Rights Agreement of the Company dated February 1, 1999 are
terminated prior to the Closing:

          (b)  The Company shall use commercially reasonable efforts to ensure
that all provisions in Contracts that provide any Person with rights of any
nature with respect to the board of directors of the Company (except as provided
generally by the Company's Certificate of Incorporation and Bylaws (or similar
organizational documents) or by applicable Legal Requirements) are validly and
effectively terminated as of the Effective Time.

     5.12 FIRPTA Matters. At the Closing, (a) the Company shall deliver to
Parent a statement (in such form as may be reasonably requested by counsel to
Parent) conforming to the

                                      45.
<PAGE>

requirements of Section 1.897 - 2(h)(1)(i) of the United States Treasure
Regulations, and (b) the Company shall deliver to the Internal Revenue Service
the notification required under Section 1.897 - 2(h)(2) of the United States
Treasury Regulations.

     5.13  Employee and Related Matters.

           (a)  The Company shall take any and all actions that are necessary
prior to the Closing to terminate its status as a participating employer/sponsor
of the AXYS qualified retirement plan (the "AXYS 401(k) Plan") so that the
employees of the Acquired Corporations will no longer be eligible to participate
in the AXYS 401(k) Plan as of a date that is prior to the Closing Date. Those
employees of the Acquired Corporations that continue to be employees of Parent
or any of its affiliates, including the Company, following the Closing would,
subject to any necessary transition period and the terms of such plans, be
eligible to participate in Parent's health, vacation, employee stock purchase,
stock option, 401(k) and other plans, to the same extent as comparably situated
employees of Parent and would receive credit under Parent's benefit plans for
service as an employee of the Acquired Corporations. Parent shall exercise
commercially reasonable efforts to minimize the duration of any necessary
transition period and to amend or replace Parent's existing plans as Parent, in
its reasonable discretion believes necessary to comply with this Section
5.13(a).

           (b)  At the Closing, the Company shall terminate its 2000 Incentive
Compensation Plan and its 2000 Merit Compensation Plan, and shall ensure that no
employee or former employee of any Acquired Corporation has any rights under any
of such Plans and that any liabilities of the Acquired Corporations under such
Plans (including any such liabilities relating to services performed prior to
the Closing) are fully extinguished at no cost to the Acquired Corporations.

SECTION 6. Conditions Precedent To Obligations Of Parent And Merger Sub

           The obligations of Parent and Merger Sub to effect the Merger
and otherwise consummate the transactions contemplated by this Agreement are
subject to the satisfaction, at or prior to the Closing, of each of the
following conditions:

     6.1   Accuracy of Representations. Each of the representations and
warranties made by the Company in this Agreement and in each of the other
agreements and instruments delivered to Parent in connection with the
transactions contemplated by this Agreement shall have been accurate in all
material respects as of the date of this Agreement (except to the extent that
such representations and warranties relate to a specific date, in which case
such representations and warranties shall be accurate on and as of such specific
date), and shall be accurate in all material respects as of the Closing as if
made at the Closing (except to the extent that such representations and
warranties relate to a specific date, in which case such representations and
warranties shall be accurate on and as of such specific date); provided,
however, that for purposes of determining the accuracy of such representations
and warranties for purposes of this Section 6.1, all "Material Adverse Effect,"
other materiality qualifications and other similar qualifications contained in
such representations and warranties shall be disregarded.

                                      46.
<PAGE>

     6.2  Performance of Covenants. All of the covenants and obligations that
the Company is required to comply with or to perform at or prior to the Closing
shall have been complied with and performed in all material respects.

     6.3  Stockholder Approval. The adoption of this Agreement and the approval
of the transactions contemplated hereby shall have been duly approved by the
affirmative vote of all of the shares of Company Series A Preferred Stock and at
least 95% of the shares of Company Common Stock entitled to vote with respect
thereto.

     6.4  Consents. All Consents required to be obtained in connection with the
Merger and the other transactions contemplated by this Agreement (including the
Consents identified in Part 2.21 of the Company Disclosure Schedule) shall have
been obtained and shall be in full force and effect.

     6.5  Agreements and Documents. Parent and the Company shall have received
the following agreements and documents, each of which shall be in full force and
effect:

          (a)  Employment Agreements in the form of Exhibit H, executed by the
     individuals identified on Exhibit G;

          (b)  Noncompetition Agreements in the form of Exhibit F, executed by
     the Major Stockholders;

          (c)  Releases in the form of Exhibit I, executed by the Major
     Stockholders;

          (d)  the statement referred to in Section 5.12, executed by the
     Company;

          (e)  the documents listed as Exhibits to this Agreement set forth in
     Section 5.10(a);

          (f)  a legal opinion of Heller Ehrman White & McAuliffe LLP, dated as
     of the Closing Date, in the form of Exhibit S;

          (g)  a legal opinion of Cooley Godward LLP (or, if Cooley Godward LLP
     for any reason does not render such legal opinion, a legal opinion of
     Heller Ehrman White & McAuliffe LLP), dated as of the Closing Date, to the
     effect that the Merger will constitute a reorganization within the meaning
     of Section 368 of the Code (it being understood that, in rendering such
     opinion, such counsel may rely upon the tax representation letters referred
     to in Section 5.5;

          (h)  written resignations of all directors and officers of the
     Company, effective as of the Effective Time;

          (i)  an Underwriter Lock-up Agreement in the form of Exhibit J,
     executed by each of the Major Stockholders;

          (j)  an Escrow Agreement in the form of Exhibit C, executed by the
     Stockholders' Agent and the Stockholders' Agent;

                                      47.
<PAGE>

          (k)  the Amended and Restated Investor Rights Agreement in the form of
     Exhibit Q, executed by each of the Major Stockholders;

          (l)  the Amended and Restated Co-Sale Agreement in the form of Exhibit
     R, executed by each of the Major Stockholders; and

          (m)  a certificate executed by the Chief Executive Officer of the
     Company and containing the representation and warranty of each of them that
     the conditions set forth in Sections 6.1, 6.2, 6.3, 6.4, 6.6 and 6.8 have
     been duly satisfied (the "Company Closing Certificate").

     6.6  Absence of Material Adverse Effect. Since the date of this Agreement,
there shall not have occurred any Material Adverse Effect on the Company, and no
event shall have occurred or circumstance shall exist that, in combination with
any other events or circumstances, could reasonably be expected to have a
Material Adverse Effect on the Company.

     6.7  HSR Act. The waiting period applicable to the consummation of the
exercise of the PPD Call, as such term is defined in the Company's Investor
Rights Agreement, under the HSR Act shall have expired or been terminated, and
there shall not be in effect any voluntary agreement between PPD and the Federal
Trade Commission or the Department of Justice pursuant to which PPD has agreed
not to consummate the exercise of the PPD Call for any period of time; any
similar waiting period applicable to the Merger or the exercise of the PPD Call
under any applicable foreign antitrust law or regulation shall have expired or
been terminated; and any Consent required under any applicable foreign antitrust
law or regulation in connection with the Merger or the exercise of the PPD call
shall have been obtained.

     6.8  FIRPTA Compliance. The Company shall have filed with the Internal
Revenue Service the notification referred to in Section 5.12.

     6.9  No Restraints. No temporary restraining order, preliminary or
permanent injunction or other order preventing the consummation of the Merger
shall have been issued by any court of competent jurisdiction and remain in
effect, and there shall not be any Legal Requirement enacted or deemed
applicable to the Merger that makes consummation of the Merger illegal.

     6.10 No Legal Proceedings. No Person shall have commenced or threatened to
commence any Legal Proceeding (a) challenging or seeking the recovery of a
material amount of damages in connection with the Merger, (b) seeking to
prohibit or limit the exercise by Parent of any material right pertaining to its
ownership of stock of the Surviving Corporation, or (c) claiming to own any
capital stock of the Company, or option or other right to acquire capital stock
of the Company or any other Acquired Corporation, or right to receive
consideration as a result of the Merger.

     6.11 Employees. Parent shall have received assurances reasonably
satisfactory to it that none of the individuals identified on Exhibit G shall
have ceased to be employed by, or expressed an intention to terminate their
employment with, the Company.

                                      48.
<PAGE>

     6.12  Termination of Certain Agreements. The Company shall have provided
Parent with evidence, reasonably satisfactory to Parent, as to the termination
of those agreements listed in Section 5.11.

     6.13  Closing of Series C Investment. Parent and PPD shall have closed the
acquisition of Parent Series C Preferred Stock by PPD (the "Series C
Investment").

     6.14  Amended and Restated Certificate. The Amended and Restated
Certificate shall have been accepted for filing by the Secretary of State of the
State of Delaware.

     6.15  Company Amended and Restated Certificate. The Company Amended and
Restated Certificate shall have been accepted for filing by the Secretary of
State of the State of Delaware.

SECTION 7. CONDITIONS PRECEDENT TO OBLIGATIONS OF THE COMPANY

           The obligations of the Company to effect the Merger and otherwise
consummate the transactions contemplated by this Agreement are subject to the
satisfaction, at or prior to the Closing, of the following conditions:

     7.1   Accuracy of Representations. Each of the representations and
warranties made by Parent and Merger Sub in this Agreement shall have been
accurate in all material respects as of the date of this Agreement (except to
the extent that such representations and warranties relate to a specific date,
in which case such representations and warranties shall be accurate on and as of
such specific date), and shall be accurate in all material respects as of the
Closing as if made at the Closing (except to the extent that such
representations and warranties relate to a specific date, in which case such
representations and warranties shall be accurate on and as of such specific
date); provided, however, that for purposes of determining the accuracy of such
representations and warranties for purposes of this Section 7.1, all "Material
Adverse Effect," other materiality qualifications and other similar
qualifications contained in such representations and warranties shall be
disregarded.

     7.2   Performance of Covenants. All of the covenants and obligations that
Parent and Merger Sub are required to comply with or to perform at or prior to
the Closing shall have been complied with and performed in all material
respects.

     7.3   Documents. The Company shall have received the following documents:

           (a) a legal opinion of Cooley Godward LLP, dated as of the Closing
     Date, in the form of Exhibit T;

           (b) a legal opinion of Heller Ehrman White & McAuliffe LLP (or, if
     Heller Ehrman White & McAuliffe LLP for any reason does not render such
     legal opinion, a legal opinion of Cooley Godward LLP), dated as of the
     Closing Date, to the effect that the Merger will constitute a
     reorganization within the meaning of Section 368 of the Code (it being
     understood that, in rendering such opinion, such counsel may rely upon the
     tax representation letters referred to in Section 5.6; and

                                      49.
<PAGE>

           (c)  an Escrow Agreement in the form of Exhibit C, executed by Parent
     and the Escrow Agent, which Escrow Agreement shall be in full force and
     effect.

     7.4   No Restraints. No temporary restraining order, preliminary or
permanent injunction or other order preventing the consummation of the Merger
shall have been issued by any court of competent jurisdiction and remain in
effect, and there shall not be any Legal Requirement enacted or deemed
applicable to the Merger that makes consummation of the Merger illegal.

     7.5   Absence of Material Adverse Effect. Since the date of this Agreement,
there shall not have occurred any Material Adverse Effect on Parent, and no
event shall have occurred or circumstance shall exist that, in combination with
any other events or circumstances, could reasonably be expected to have a
Material Adverse Effect on Parent.

     7.6   HSR Act. The waiting period applicable to the consummation of the
exercise of the PPD Call under the HSR Act shall have expired or been
terminated, and there shall not be in effect any voluntary agreement between PPD
and the Federal Trade Commission or the Department of Justice pursuant to which
PPD has agreed not to consummate the exercise of the PPD Call for any period of
time; any similar waiting period applicable to the Merger or the exercise of the
PPD Call under any applicable foreign antitrust law or regulation shall have
expired or been terminated; and any Consent required under any applicable
foreign antitrust law or regulation in connection with the Merger or the
exercise of the PPD Call shall have been obtained.

     7.7   Amended and Restated Certificate. The Amended and Restated
Certificate shall have been accepted for filing by the Secretary of State of the
State of Delaware.

     7.8   Director Appointment. The Company shall have received evidence
reasonably satisfactory to it that immediately after the Closing, PPD shall have
the right to appoint one member of the board of directors of Parent.

     7.9   Company Amended and Restated Certificate. The Company Amended and
Restated Certificate shall have been accepted for filing by the Secretary of
State of the State of Delaware.

     7.10  Closing of Series C Investment. Parent and PPD shall have closed the
Series C Investment.

SECTION 8. Termination

     8.1   Termination Events. This Agreement may be terminated prior to the
Closing:

           (a) by Parent if Parent reasonably determines that the timely
     satisfaction of any condition set forth in Section 6 has become impossible
     (other than as a result of any failure on the part of Parent or Merger Sub
     to comply with or perform any covenant or obligation of Parent or Merger
     Sub set forth in this Agreement);

                                      50.
<PAGE>

           (b) by the Company if the Company reasonably determines that the
     timely satisfaction of any condition set forth in Section 7 has become
     impossible (other than as a result of any failure on the part of the
     Company to comply with or perform any covenant or obligation set forth in
     this Agreement or in any other agreement or instrument delivered to
     Parent);

           (c) by Parent if the Closing has not taken place on or before January
     15, 2001 (other than as a result of any failure on the part of Parent to
     comply with or perform any covenant or obligation of Parent set forth in
     this Agreement);

           (d) by the Company if the Closing has not taken place on or before
     January 15, 2001 (other than as a result of the failure on the part of the
     Company to comply with or perform any covenant or obligation set forth in
     this Agreement or in any other agreement or instrument delivered to
     Parent);

           (e) by either Parent or the Company if a Governmental Body shall have
     issued a final and nonappealable order, decree or ruling, or shall have
     taken any other action, having the effect of permanently restraining,
     enjoining or otherwise prohibiting the Merger; or

           (f) by the mutual consent of Parent and the Company.

     8.2   Termination Procedures. If Parent wishes to terminate this Agreement
pursuant to Section 8.1(a), Section 8.1(c) or Section 8.1(e), Parent shall
deliver to the Company a written notice stating that Parent is terminating this
Agreement and setting forth a brief description of the basis on which Parent is
terminating this Agreement. If the Company wishes to terminate this Agreement
pursuant to Section 8.1(b), Section 8.1(d) or Section 8.1(e), the Company shall
deliver to Parent a written notice stating that the Company is terminating this
Agreement and setting forth a brief description of the basis on which the
Company is terminating this Agreement.

     8.3   Effect of Termination. If this Agreement is terminated pursuant to
Section 8.1, all further obligations of the parties under this Agreement shall
terminate; provided, however, that: (a) neither the Company nor Parent shall be
relieved of any obligation or liability arising from any prior breach by such
party of any provision of this Agreement; (b) the parties shall, in all events,
remain bound by and continue to be subject to the provisions set forth in
Section 10; and (c) the Company shall, in all events, remain bound by and
continue to be subject to Section 5.4.

SECTION 9. Indemnification, Etc.

     9.1   Survival of Representations, Etc.

           (a) The representations and warranties made by the parties (including
the representations and warranties set forth in Section 2 and Section 3) shall
survive until the February 28, 2002 (the "Termination Date"); provided, however,
that if, at any time prior to the Termination Date, any Parent Indemnitee or
Stockholder Indemnitee (acting in good faith) delivers to the Stockholders'
Agent or Parent, as the case may be, a written notice alleging the

                                      51.
<PAGE>

existence of an inaccuracy in or a breach of any of the representations and
warranties made by the Company, on the one hand, or Parent and Merger Sub, on
the other hand, (and setting forth in reasonable detail the basis for such
Indemnitee's belief that such an inaccuracy or breach may exist) and asserting a
claim for recovery under Section 9.2 based on such alleged inaccuracy or breach,
then the claim asserted in such notice shall survive the Termination Date until
such time as such claim is fully and finally resolved.

          (b)  The representations, warranties, covenants and obligations of the
Company, on the one hand, and Parent and Merger Sub, on the other hand, and the
rights and remedies that may be exercised by the Indemnitees, shall not be
limited or otherwise affected by or as a result of any information furnished to,
or any investigation made by or knowledge of, any of the Indemnitees or any of
their Representatives.

          (c)  For purposes of this Agreement, (i) each statement or other item
of information set forth in the Company Disclosure Schedule or in any update to
the Company Disclosure Schedule shall be deemed to be a representation and
warranty made by the Company in this Agreement and (ii) each statement or other
item of information set forth in the Parent Disclosure Schedule or in any update
to the Parent Disclosure Schedule shall be deemed to be a representation and
warranty made by Parent and Merger Sub in this Agreement.

     9.2  Indemnification.

          (a)  Indemnification by Major Stockholders. From and after the Closing
(but subject to Section 9.1(a), 9.3 and 9.4), the Major Stockholders, jointly
and severally shall hold harmless and indemnify each of the Parent Indemnitees
from and against, and shall compensate and reimburse each of the Parent
Indemnitees for, any Damages that are suffered or incurred by any of the Parent
Indemnitees or to which any of the Parent Indemnitees may otherwise become
subject (regardless of whether or not such Damages relate to any third-party
claim) and that arise from or as a result of, or are directly or indirectly
connected with: (i) any inaccuracy in or breach of any representation or
warranty made by the Company in Section 2 of this Agreement (without giving
effect to any "Material Adverse Effect" or other materiality qualification or
any similar qualification contained or incorporated directly in such
representation or warranty, and without giving effect to any update to the
Company Disclosure Schedule delivered by the Company to Parent prior to the
Closing); (ii) any inaccuracy in or breach of any representation or warranty
made by the Company in Section 2 as if such representation and warranty had been
made on and as of the Closing Date (except for such representations and
warranties that address matters only as of a particular time, which need only be
accurate as of such time) (after having given effect to any updates to the
Company Disclosure Schedule delivered to Parent prior to the Closing pursuant to
Section 4.3(b), but without giving effect to any "Material Adverse Effect" or
other materiality qualification or any similar qualification contained or
incorporated directly in such representation or warranty); (iii) any breach of
any covenant or obligation of the Company in this Agreement to be performed
prior to the Closing (including, without limitation, the covenants set forth in
Sections 4 and 5); (iv) any claim or demand made by the Company's legal counsel,
accountants, the Company Financial Advisors or other advisors with respect to
fees, costs or expenses payable to them in connection with the transactions
contemplated by this Agreement to the extent that such fees, costs and expenses
constitute Excess Transaction Expenses and exceed the Excess Transaction
Expenses,

                                      52.
<PAGE>

if any, used in determining the Parent Share Number in Section 1.5; or (v) any
Legal Proceeding relating to (Y) any inaccuracy or breach of the type referred
to in clause "(i)," "(ii)" or "(iii)" above or (Z) any claim or demand of the
type referred to in clause "(iv)" above (including with respect to each of
clause "(Y)" and clause "(Z)" of this clause "(v)," any Legal Proceeding
commenced by any Parent Indemnitee for the purpose of enforcing any of its
rights under this Section 9).

          (b)  Indemnification by Parent. From and after the Closing (but
subject to Section 9.1(a), 9.3 and 9.4), Parent shall hold harmless and
indemnify each of the Stockholder Indemnitees from and against, and shall
compensate and reimburse each of the Stockholder Indemnitees for, any Damages
that are suffered or incurred by any of the Stockholder Indemnitees or to which
any of the Stockholder Indemnitees may otherwise become subject (regardless of
whether or not such Damages relate to any third-party claim) and that arise from
or as a result of, or are directly or indirectly connected with: (i) any
inaccuracy in or breach of any representation or warranty made by Parent and
Merger Sub in Section 3 of this Agreement (without giving effect to any
"Material Adverse Effect" or other materiality qualification or any similar
qualification contained or incorporated directly in such representation or
warranty, and without giving effect to any update to the Parent Disclosure
delivered by Parent to the Company prior to the Closing); (ii) any inaccuracy in
or breach of any representation or warranty made by Parent and Merger Sub in
Section 3 as if such representation and warranty had been made on and as of the
Closing Date (except for such representations and warranties that address
matters only as of a particular time, which need only be accurate as of such
time) (after having given effect to any updates to the Parent Disclosure
Schedule delivered to the Company prior to the Closing pursuant to Section
4.4(b), but without giving effect to any "Material Adverse Effect" or other
materiality qualification or any similar qualification contained or incorporated
directly in such representation or warranty); (iii) any breach of any covenant
or obligation of Parent or Merger Sub in this Agreement to be performed prior to
the Closing (including, without limitation, the covenants set forth in Sections
4 and 5); or (iv) any Legal Proceeding relating to any inaccuracy or breach of
the type referred to in clause "(i)," "(ii)" or "(iii)" above (including any
Legal Proceeding commenced by any Stockholder Indemnitee for the purpose of
enforcing any of its rights under this Section 9).

     9.3  Deductible. The Major Stockholders, on the one hand, and Parent, on
the other hand, shall not be required to make any indemnification payment
pursuant to Section 9.2(a) or Section 9.2(b), as the case may be, for any
inaccuracy in or breach of any of (a) the Company's representations and
warranties set forth in this Agreement (in the case of the Major Stockholders)
or (b) Parent and Merger Sub's representations and warranties in this Agreement
(in the case of Parent) until such time as the total amount of all Damages
(including, without limitation, the Damages arising from such inaccuracy or
breach and all other Damages arising from any other inaccuracies in or breaches
of any representations or warranties) that have been directly or indirectly
suffered or incurred by any one or more of the Parent Indemnitees or the
Stockholder Indemnitees, as the case may be, or to which any one or more of the
Parent Indemnitees or the Stockholder Indemnitees, as the case may be, has or
have otherwise become subject, exceeds $500,000 in the aggregate. If the total
amount of such Damages exceeds $500,000, then the Parent Indemnitees or the
Stockholder Indemnitees, as the case may be, shall be entitled to be indemnified
against and compensated and reimbursed only for the portion of such Damages that
exceeds $500,000. Notwithstanding the preceding sentence, no individual claim or
series of

                                      53.
<PAGE>

related claims for indemnification under this Section 9 may be asserted unless
it is (or they are) for an amount in excess of $15,000.

     9.4  Exclusive Remedy for Monetary Damages.

          (a)  From and after the Closing, the total aggregate liability of the
Major Stockholders for Damages arising under Section 9.2(a) shall not exceed the
Escrow Fund. From and after the Closing, the total aggregate liability of Parent
for Damages arising under Section 9.2(b) shall not exceed a cash amount equal to
the aggregate value (as of the Closing Date) of the Parent Capital Stock held in
the Escrow Fund.

          (b)  Nothing in this Section 9.4 or elsewhere in this Agreement shall
affect the parties' rights to specific performance or other equitable remedies
with respect to the covenants referred to in this Agreement to be performed
after the Closing.

          (c)  In the absence of fraud or intentional misconduct, from and after
the Closing, this Section 9 sets forth the exclusive remedy for monetary Damages
owing from the Indemnitors to the Indemnitees that arise from the matters
described in Section 9.2.

     9.5  No Contribution.

No stockholder of the Company shall have any right of contribution, right of
indemnity or other right or remedy against the Surviving Corporation in
connection with any indemnification obligation or any other liability to which
he may become subject under or in connection with this Agreement.

     9.6  Interest. If the Major Stockholders, on the one hand, or Parent, on
the other hand, are required to hold harmless, indemnify, compensate or
reimburse any Parent Indemnitee or Stockholder Indemnitee, as the case may be,
pursuant to this Section 9 with respect to any Damages, then the Major
Stockholders or Parent, as the case may be, shall also be liable to such Parent
Indemnitee or Stockholder Indemitee, as the case may be, for interest on the
amount of such Damages (for the period commencing as of the date on which such
the Major Stockholders or Parent, as the case may be, first received notice of a
claim for recovery by such Parent Indemnitee or Stockholder Indemnitee, as the
case may be, and ending on the date on which the liability of the Major
Stockholders or Parent, as the case may be, to is fully satisfied) at a floating
rate equal to the rate of interest publicly announced by Bank of America, N.T. &
S.A. from time to time as its prime, base or reference rate.

     9.7  Defense of Third Party Claims. In the event of the assertion or
commencement by any Person of any claim or Legal Proceeding (whether against the
Surviving Corporation, against Parent or against any other Person) with respect
to which any of the Major Stockholders may become obligated to hold harmless,
indemnify, compensate or reimburse any Indemnitee pursuant to this Section 9,
Parent shall have the right, at its election, to proceed with the defense of
such claim or Legal Proceeding on its own. If Parent so proceeds with the
defense of any such claim or Legal Proceeding:

          (a)  all reasonable expenses relating to the defense of such claim or
     Legal Proceeding shall be borne and paid exclusively by the Major
     Stockholders;

                                      54.
<PAGE>

            (b) each Major Stockholder shall make available to Parent any
     documents and materials in his possession or control that may be necessary
     to the defense of such claim or Legal Proceeding; and

            (c) Parent shall not have the right to settle, adjust or compromise
     such claim or Legal Proceeding with the consent of the Stockholders' Agent
     (as defined in Section 10.1); provided, however, that such consent shall
     not be unreasonably withheld.

Parent shall give the Stockholders' Agent prompt notice of the commencement of
any such Legal Proceeding against Parent or the Surviving Corporation; provided,
however, that any failure on the part of Parent to so notify the Stockholders'
Agent shall not limit any of the obligations of the Major Stockholder under this
Section 9 (except to the extent such failure materially prejudices the defense
of such Legal Proceeding).

     9.8    Exercise of Remedies by Parent Indemnitees Other Than Parent. No
Parent Indemnitee (other than Parent or any successor thereto or assign thereof)
shall be permitted to assert any indemnification claim or exercise any other
remedy under this Agreement unless Parent (or any successor thereto or assign
thereof) shall have consented to the assertion of such indemnification claim or
the exercise of such other remedy.

SECTION 10. Miscellaneous Provisions

     10.1   Stockholders' Agents. By virtue of their adoption of this Agreement
and approval of the transactions contemplated hereby, the stockholders of the
Company hereby irrevocably appoint Bill Newell and Fred Davenport as their joint
agents for purposes of Section 9 (the "Stockholders' Agents"), and Bill Newell
and Fred Davenport hereby accept their appointment as the Stockholders' Agents.
Parent shall be entitled to deal exclusively with the Stockholders' Agents on
all matters relating to Section 9, and shall be entitled to rely conclusively
(without further evidence of any kind whatsoever) on any document executed or
purported to be executed on behalf of any Merger Stockholder by both of the
Stockholders' Agents, and on any other action taken or purported to be taken on
behalf of any Merger Stockholder by the Stockholders' Agents, as fully binding
upon such stockholder. If one of the Stockholders' Agents shall die, become
disabled or otherwise be unable to fulfill his responsibilities as agent of the
Merger Stockholders, then the Merger Stockholders shall, within ten days after
such death or disability, appoint a successor agent and, promptly thereafter,
shall notify Parent of the identity of such successor. Any such successor shall
become a "Stockholders' Agents" for purposes of Section 9 and this Section 10.1.
If for any reason there is no Stockholders' Agent at any time, all references
herein to the Stockholders' Agents shall be deemed to refer to the Merger
Stockholders.

     10.2   Further Assurances. Each party hereto shall execute and cause to be
delivered to each other party hereto such instruments and other documents, and
shall take such other actions, as such other party may reasonably request (prior
to, at or after the Closing) for the purpose of carrying out or evidencing any
of the transactions contemplated by this Agreement.

     10.3   Fees and Expenses. Subject to Section 9.2(a), each party to this
Agreement shall bear and pay all fees, costs and expenses (including legal fees,
costs and expenses and

                                      55.
<PAGE>

accounting fees, costs and expenses) that have been incurred or that are
incurred by such party in connection with the transactions contemplated by this
Agreement.

     10.4   Attorneys' Fees. If any action or proceeding relating to this
Agreement or the enforcement of any provision of this Agreement is brought
against any party hereto, the prevailing party shall be entitled to recover
reasonable attorneys' fees, costs and disbursements (in addition to any other
relief to which the prevailing party may be entitled).

     10.5   Notices. Any notice or other communication required or permitted to
be delivered to any party under this Agreement shall be in writing and shall be
deemed properly delivered, given and received when delivered (by hand, by
registered mail, by courier or express delivery service or by facsimile) to the
address or facsimile telephone number set forth beneath the name of such party
below (or to such other address or facsimile telephone number as such party
shall have specified in a written notice given to the other parties hereto):

            if to Parent:

            DNA Sciences, Inc.
            2375 Garcia Avenue
            Mountain View, CA. 94043
            Attention:
            Phone: (650)
            Fax: (650)

            with a copy to:

            Cooley Godward LLP
            3000 El Camino Real
            5 Palo Alto Square
            Palo Alto, CA 94306
            Attention: Robert L. Jones
            Phone: (650) 843-5000
            Fax: (650) 849-7400

            if to the Company:

            PPGx, Inc.
            11099 North Torrey Pines Road
            La Jolla, CA 92037
            Attention: Josh Baker
            Phone: (919) 463-6702
            Fax: (919) 379-6029

            with a copy to:

            Heller Ehrman White & McAuliffe LLP

                                      56.
<PAGE>

            4250 Executive Square, 7/th/ Floor
            La Jolla, CA 92037
            Attention: Stephen C. Ferruolo
            Phone: (858) 450-8430
            Fax: (858) 450-8499


            if to the Stockholders' Agents:

            Fred Davenport
            Pharmaceutical Product Development, Inc.
            3151 South 17/th/ Street
            Wilmington, NC 28412
            Phone: (910) 251-0081
            Fax: (910) 772-6951

            Bill Newell
            Axys Pharmaceuticals, Inc.
            180 Kimball Way
            South San Francisco, CA 94080
            Phone: (650) 829-1000
            Fax: (650) 829-1001

     10.6   Confidentiality. Without limiting the generality of anything
contained in Section 5.6, on and at all times after the Closing Date, each party
to this Agreement shall keep confidential, and shall not use or disclose to any
other Person, any non-public document or other non-public information in such
stockholder's possession that relates to the business of the Company or Parent.

     10.7   Time of the Essence. Time is of the essence of this Agreement.

     10.8   Headings. The underlined headings contained in this Agreement are
for convenience of reference only, shall not be deemed to be a part of this
Agreement and shall not be referred to in connection with the construction or
interpretation of this Agreement.

     10.9   Counterparts. This Agreement may be executed in several
counterparts, each of which shall constitute an original and all of which, when
taken together, shall constitute one agreement.

     10.10  Governing Law. This Agreement shall be construed in accordance with,
and governed in all respects by, the internal laws of the State of Delaware
(without giving effect to principles of conflicts of laws).

     10.11  Successors and Assigns. This Agreement shall be binding upon the
Company and its successors and assigns (if any), Parent and its successors and
assigns (if any), and Merger Sub and its successors and assigns (if any). This
Agreement shall inure to the benefit of: the Company, the Company's stockholders
(to the extent set forth in Section 1.5) and the

                                      57.
<PAGE>

Stockholder Indemnitees (to the extent set forth in Section 9), the holders of
assumed Company Options (to the extent set forth in Section 1.6), Parent, Merger
Sub, the other Parent Indemnitees (subject to Section 9.6), and the respective
successors and assigns (if any) of the foregoing. Parent may freely assign any
or all of its rights under Section 9, in whole or in part, to any other Person
without obtaining the consent or approval of any other party hereto or of any
other Person.

     10.12  Remedies Cumulative; Specific Performance. The rights and remedies
of the parties hereto shall be cumulative (and not alternative). The parties to
this Agreement agree that, in the event of any breach or threatened breach by
any party to this Agreement of any covenant, obligation or other provision set
forth in this Agreement for the benefit of any other party to this Agreement,
such other party shall be entitled (in addition to any other remedy that may be
available to it) to (a) a decree or order of specific performance or mandamus to
enforce the observance and performance of such covenant, obligation or other
provision, and (b) an injunction restraining such breach or threatened breach.

     10.13  Waiver.

            (a)  No failure on the part of any Person to exercise any power,
right, privilege or remedy under this Agreement, and no delay on the part of any
Person in exercising any power, right, privilege or remedy under this Agreement,
shall operate as a waiver of such power, right, privilege or remedy; and no
single or partial exercise of any such power, right, privilege or remedy shall
preclude any other or further exercise thereof or of any other power, right,
privilege or remedy.

            (b)  No Person shall be deemed to have waived any claim arising out
of this Agreement, or any power, right, privilege or remedy under this
Agreement, unless the waiver of such claim, power, right, privilege or remedy is
expressly set forth in a written instrument duly executed and delivered on
behalf of such Person; and any such waiver shall not be applicable or have any
effect except in the specific instance in which it is given.

     10.14  Amendments. This Agreement may not be amended, modified, altered or
supplemented other than by means of a written instrument duly executed and
delivered on behalf of all of the parties hereto.

     10.15  Severability. In the event that any provision of this Agreement, or
the application of any such provision to any Person or set of circumstances,
shall be determined to be invalid, unlawful, void or unenforceable to any
extent, the remainder of this Agreement, and the application of such provision
to Persons or circumstances other than those as to which it is determined to be
invalid, unlawful, void or unenforceable, shall not be impaired or otherwise
affected and shall continue to be valid and enforceable to the fullest extent
permitted by law.

     10.16  Parties in Interest. Except for the provisions of Sections 1.5, 1.6
and 9, none of the provisions of this Agreement is intended to provide any
rights or remedies to any Person other than the parties hereto and their
respective successors and assigns (if any).

     10.17  Entire Agreement. This Agreement and the other agreements referred
to herein set forth the entire understanding of the parties hereto relating to
the subject matter hereof and

                                      58.
<PAGE>

thereof and supersede all prior agreements and understandings among or between
any of the parties relating to the subject matter hereof and thereof; provided,
however, that the Confidentiality and Non-Disclosure Agreement executed on
behalf of Parent and the Company on September 6, 2000 shall not be superseded by
this Agreement and shall remain in effect in accordance with its terms until the
earlier of (a) the Effective Time, or (b) the date on which such Confidentiality
and Nondisclosure Agreement is terminated in accordance with its terms.

     10.18  Construction.

            (a)  For purposes of this Agreement, whenever the context requires:
the singular number shall include the plural, and vice versa; the masculine
gender shall include the feminine and neuter genders; the feminine gender shall
include the masculine and neuter genders; and the neuter gender shall include
the masculine and feminine genders.

            (b)  The parties hereto agree that any rule of construction to the
effect that ambiguities are to be resolved against the drafting party shall not
be applied in the construction or interpretation of this Agreement.

            (c)  As used in this Agreement, the words "include" and "including,"
and variations thereof, shall not be deemed to be terms of limitation, but
rather shall be deemed to be followed by the words "without limitation."

            (d)  Except as otherwise indicated, all references in this Agreement
to "Sections" and "Exhibits" are intended to refer to Sections of this Agreement
and Exhibits to this Agreement.

                                      59.
<PAGE>

     The parties hereto have caused this Agreement to be executed and delivered
as of December 17, 2000.

                                  DNA Sciences, Inc.,
                                   a Delaware corporation

                            By: /s/ Steve B. Lehrer                       (SEAL)
                                -----------------------------------------
                             Name: Steve B. Lehrer                          .
                                   --------------------------------------
                             Title: Chief Business Officer                  .
                                    -------------------------------------




                                  PIPO Acquisition Corp.,
                                   a Delaware corporation

                            By: /s/ Steve B. Lehrer                       (SEAL)
                             --------------------------------------------
                             Name: Steve B. Lehrer                          .
                                   --------------------------------------
                             Title: President & Chief Executive Officer     .
                             --------------------------------------------



                                  PPGx, Inc.,
                                   a Delaware corporation

                            By: /s/ Joshua S. Baker                       (SEAL)
                                -----------------------------------------
                             Name: Joshua S. Baker                          .
                                   --------------------------------------
                             Title: President                               .
                                    -------------------------------------

                                      60.
<PAGE>

                                   EXHIBITS

Exhibit A   -   Certain definitions

Exhibit B   -   Form of Voting Agreement

Exhibit C   -   Form of Escrow Agreement

Exhibit D   -   Form of Amended and Restated Certificate

Exhibit E   -   Forms of tax representation letters

Exhibit F   -   Form of Noncompetition Agreement

Exhibit G   -   Persons to Execute Offer Letters

Exhibit H   -   Form of Offer Letter

Exhibit I   -   Form of Release

Exhibit J   -   Form of Underwriter Lockup Agreement

Exhibit K   -   Form of Amended and Restated Distributor Agreement

Exhibit L   -   Form of Amended and Restated Technology Transfer Agreement

Exhibit M   -   Form of PPD Clarification Letter

Exhibit N   -   Form of PPD Real Property Indemnity Letter

Exhibit O   -   Form of Axys Covenant Not to Sue

Exhibit P   -   Form of Axys Assignment Letter

Exhibit Q   -   Form of Amended and Restated Investor Rights Agreement

Exhibit R   -   Form of Amended and Restated Co-Sale Agreement

Exhibit S   -   Form of legal opinion of Heller Ehrman White & McAuliffe LLP

Exhibit T   -   Form of legal opinion of Cooley Godward LLP

                                      1.
<PAGE>

                                   EXHIBIT A

                              CERTAIN DEFINITIONS

     For purposes of the Agreement (including this Exhibit A):

     Acquired Corporation Contract. "Acquired Corporation Contract" shall mean
any contract: (a) to which any of the Acquired Corporations is a party; (b) by
which any of the Acquired Corporations or any asset of any of the Acquired
Corporations is or may become bound or under which any of the Acquired
Corporations has, or may become subject to, any obligation; or (c) under which
any of the Acquired Corporations has or may acquire any right or interest.

     Acquired Corporation Proprietary Asset. "Acquired Corporation Proprietary
Asset" shall mean any Proprietary Asset owned by or licensed to any of the
Acquired Corporations or otherwise used by any of the Acquired Corporations.

     Acquisition Transaction. "Acquisition Transaction" shall mean any
transaction involving:

          (a)  the sale, license, disposition or acquisition of all or a
     material portion of the any of the Acquired Corporations' business or
     assets;

          (b)  the issuance, disposition or acquisition of (i) any capital stock
     or other equity security of any of the Acquired Corporations' (other than
     common stock issued to employees of the Acquired Corporations, upon
     exercise of Company Options or otherwise, in routine transactions in
     accordance with the Acquired Corporations' past practices), (ii) any
     option, call or right (whether or not immediately exercisable) to acquire
     any capital stock or other equity security of the any of the Acquired
     Corporations (other than stock options granted to employees of the Acquired
     Corporations in routine transactions in accordance with the Acquired
     Corporations' past practices), or (iii) any security, instrument or
     obligation that is or may become convertible into or exchangeable for any
     capital stock or other equity security of any of the Acquired Corporations;
     or

          (c)  any merger, consolidation, business combination, reorganization
     or similar transaction involving any of the Acquired Corporations.

     Agreement. "Agreement" shall mean the Agreement and Plan of Merger and
Reorganization to which this Exhibit A is attached (including the Company
Disclosure Schedule and the Parent Disclosure Schedule), as it may be amended
from time to time.

     Company Capital Stock. "Company Capital Stock" shall mean, collectively,
the Company Common Stock and the Company Series A Preferred Stock.

     Company Disclosure Schedule. "Company Disclosure Schedule" shall mean the
schedule (dated as of the date of the Agreement) delivered to Parent on behalf
of the Company.

     Consent. "Consent" shall mean any approval, consent, ratification,
permission, waiver or authorization (including any Governmental Authorization).

                                      1.
<PAGE>

     Contract. "Contract" shall mean any written, oral or other agreement,
contract, subcontract, lease, understanding, instrument, note, warranty,
insurance policy, benefit plan or legally binding commitment or undertaking of
any nature.

     Damages. "Damages" shall include any loss, damage, injury, decline in
value, lost opportunity, liability, claim, demand, settlement, judgment, award,
fine, penalty, Tax, fee (including reasonable attorneys' fees), charge, cost
(including costs of investigation) or expense of any nature.

     Encumbrance. "Encumbrance" shall mean any lien, pledge, hypothecation,
charge, mortgage, security interest, encumbrance, claim, infringement,
interference, option, right of first refusal, preemptive right, community
property interest or restriction of any nature (including any restriction on the
voting of any security, any restriction on the transfer of any security or other
asset, any restriction on the receipt of any income derived from any asset, any
restriction on the use of any asset and any restriction on the possession,
exercise or transfer of any other attribute of ownership of any asset).

     Entity. "Entity" shall mean any corporation (including any non-profit
corporation), general partnership, limited partnership, limited liability
partnership, joint venture, estate, trust, company (including any limited
liability company or joint stock company), firm or other enterprise,
association, organization or entity.

     Excess Transaction Expenses. "Excess Transaction Expenses" shall mean (A)
50% of the first $400,000 in aggregate fees, costs and expenses payable by the
Company to the Company's legal counsel, accountants and other advisors (other
than P2 Partners (the "Company Financial Advisor") and incurred in connection
with the transactions contemplated by this Agreement, plus (B) 100% of the
aggregate fees, costs and expenses payable to the Company's legal counsel,
accountants and other advisors (other than the Company Financial Advisor) in
excess of $400,000 and incurred in connection with the transactions contemplated
by this Agreement, plus (C) all fees, costs and expenses payable by the Company
to the Company Financial Advisor and incurred in connection with the
transactions contemplated by this Agreement.

     Governmental Authorization. "Governmental Authorization" shall mean any:
(a) permit, license, certificate, franchise, permission, clearance,
registration, qualification or authorization issued, granted, given or otherwise
made available by or under the authority of any Governmental Body or pursuant to
any Legal Requirement; or (b) right under any Contract with any Governmental
Body.

     Governmental Body. "Governmental Body" shall mean any: (a) nation, state,
commonwealth, province, territory, county, municipality, district or other
jurisdiction of any nature; (b) federal, state, local, municipal, foreign or
other government; or (c) governmental or quasi-governmental authority or
component of any nature (including any governmental branch, division,
department, agency, commission, instrumentality, official, organization, unit,
body or Entity and any court or other tribunal).

     Indemnitees. "Indemnitees" shall mean the Parent Indemnitees and the
Stockholder Indemnitees.

                                      2.
<PAGE>

     Knowledge. Information shall be deemed "known to" or "to the Knowledge" of
the Company if that information is actually known by any of Josh Baker or Jeff
Hall or should be known to such individual after reasonable inquiry by such
individual. Information shall be deemed "known to" or "to the Knowledge" of
Parent if that information is actually known by any officer or director of
Parent or should be known to such officer or director after reasonable inquiry
by such officer or director.

     Legal Proceeding. "Legal Proceeding" shall mean any action, suit,
litigation, arbitration, proceeding (including any civil, criminal,
administrative, investigative or appellate proceeding), hearing, inquiry, audit,
examination or investigation commenced, brought, conducted or heard by or
before, or otherwise involving, any court or other Governmental Body or any
arbitrator or arbitration panel.

     Legal Requirement. "Legal Requirement" shall mean any federal, state,
local, municipal, foreign or other law, statute, constitution, principle of
common law, resolution, ordinance, code, edict, decree, rule, regulation,
publicly available administrative interpretation, ruling or requirement issued,
enacted, adopted, promulgated, implemented or otherwise put into effect by or
under the authority of any Governmental Body.

     Material Adverse Effect. A "Material Adverse Effect" on the Acquired
Corporations means any change, effect, event, occurrence, state of facts or
development that is materially adverse to the business, condition, assets,
liabilities, operations or financial performance of one or more of the Acquired
Corporations. A "Material Adverse Effect" on Parent means any change, effect,
event, occurrence, state of facts or development that is materially adverse to
the business, condition, assets, liabilities, operations or financial
performance of Parent; provided, however, that any adverse change, effect,
event, occurrence, state of facts or development affecting Parent's ability to
obtain or arrange public or private debt or equity financing on terms acceptable
to Parent or otherwise adversely affecting the financial markets in general or
the financial markets for the industry sector in which Parent competes shall not
be deemed to constitute, nor taken into account in determining whether there has
been, a Material Adverse Effect on Parent; provided further however, that any
adverse change, effect, event, occurrence, state of facts or development
referred to in the preceding proviso will be taken into account in determining
whether there has been a Material Adverse Effect on Parent (but will not in and
of itself constitute a Material Adverse Effect on Parent) if such adverse
change, effect, event, occurrence, state of facts or development resulted from
the gross negligence or willful misconduct of Parent or its Representatives and
such adverse change, effect, event, occurrence, state of facts or development
has resulted in an obligation of Parent to pay money damages in an amount in
excess of $300,000.

     Parent Disclosure Schedule. "Parent Disclosure Schedule" shall mean the
schedule (dated as of the date of the Agreement) delivered to the Company on
behalf of Parent and Merger Sub.

     Parent Indemnitees. "Parent Indemnitees" shall mean the following Persons:
(a) Parent; (b) Parent's current and future affiliates (including the Surviving
Corporation); (c) the respective Representatives of the Persons referred to in
clauses "(a)" and "(b)" above; and (d) the respective successors and assigns of
the Persons referred to in clauses "(a)", "(b)" and "(c)"

                                      3.
<PAGE>

above; provided, however, that the stockholders of the Company shall not be
deemed to be "Parent Indemnitees."

     Parent Preferred Stock. "Parent Preferred Stock" shall mean collectively,
the Series A Preferred Stock ($0.001 par value per share) of Parent, the Series
B Preferred Stock ($0.001 par value per share) of Parent, the Parent Series C
Preferred Stock and the Parent Series D Preferred Stock.

     Parent Series C Preferred Stock. "Parent Series C Preferred Stock" shall
mean the Series C Preferred Stock (0.001 par value per share) of Parent.

     Permitted Encumbrance. "Permitted Encumbrance" shall mean any (i) any
Encumbrance for Taxes (other than income taxes) either not yet due and payable
or being contested in good faith by appropriate proceedings and for which
adequate reserves have been established on the Acquired Corporation Financial
Statements in accordance with generally accepted accounting principles applied
on a consistent basis throughout the periods covered and (ii) mechanic's,
materialmen's, workmen's, warehousemen's and other similar liens incurred in the
ordinary course of business with respect to obligations that are not past due or
that are being contested in good faith by appropriate proceedings and for which
adequate reserves have been established on the Acquired Corporation Financial
Statements in accordance with generally accepted accounting principles applied
on a consistent basis throughout the periods covered.

     Person. "Person" shall mean any individual, Entity or Governmental Body.

     Proprietary Asset. "Proprietary Asset" shall mean any: (a) patent, patent
application, trademark (whether registered or unregistered), trademark
application, trade name, fictitious business name, service mark (whether
registered or unregistered), service mark application, copyright (whether
registered or unregistered), copyright application, maskwork, maskwork
application, trade secret, know-how, customer list, franchise, system, computer
software, computer program, source code, algorithm, invention, design,
proprietary product, technology, proprietary right or other intellectual
property right or intangible asset; or (b) right to use or exploit any of the
foregoing.

     Representatives. "Representatives" shall mean officers, directors,
employees, agents, attorneys, accountants, advisors and representatives.

     Subsidiary. An entity shall be deemed to be a "Subsidiary" of another
Person if such Person directly or indirectly owns, beneficially or of record,
(a) an amount of voting securities of other interests in such Entity that is
sufficient to enable such Person to elect at least a majority of the members of
such Entity's board of directors or other governing body, or (b) at least 50% of
the outstanding equity or financial interests or such Entity.

     Stockholder Indemnitees. "Stockholder Indemnitees" shall mean the following
Persons: (a) the Merger Stockholders; (b) the Merger Stockholders' current and
future affiliates; (c) the respective Representatives of the Persons referred to
in clauses "(a)" and "(b)" above; and (d) the respective successors and assigns
of the Persons referred to in clauses "(a)", "(b)" and "(c)" above; provided,
however, that the Company shall not be deemed to be a "Stockholder Indemnitee."

                                      4.
<PAGE>

     Tax. "Tax" shall mean any tax (including any income tax, franchise tax,
capital gains tax, gross receipts tax, value-added tax, surtax, excise tax, ad
valorem tax, transfer tax, stamp tax, sales tax, use tax, property tax, business
tax, withholding tax or payroll tax), levy, assessment, tariff, duty (including
any customs duty), deficiency or fee, and any related charge or amount
(including any fine, penalty or interest), imposed, assessed or collected by or
under the authority of any Governmental Body.

     Tax Return. "Tax Return" shall mean any return (including any information
return), report, statement, declaration, estimate, schedule, notice,
notification, form, election, certificate or other document or information filed
with or submitted to, or required to be filed with or submitted to, any
Governmental Body in connection with the determination, assessment, collection
or payment of any Tax or in connection with the administration, implementation
or enforcement of or compliance with any Legal Requirement relating to any Tax.

                                      5.