Exhibit 10.10


 


SECOND AMENDMENT
TO LEASE


 


This Second Amendment
to Lease (‘‘Amendment”) is made effective as of June 1, 2015, by and between PLAZA DEL ORO GREEN, L.P., a Delaware
limited liability company (“Landlord”) and PLx PHARMA INC. a Texas corporation (“Tenant”) with reference
to the following facts and circumstances.


 


		A.	Landlord is the owner of that certain building located at 8285 El Rio, Houston, Texas 77054 (the
“Building”).



 


		B.	Teachers Insurance and Annuity Association of America, predecessor in interest to Landlord, and
Tenant entered into that certain Industrial Multi-Tenant Lease dated June 4, 2009, as amended by that certain First Amendment to
Lease dated May 22, 2014, (collectively, the “Lease”) for certain premises containing approximately 3,905 rentable
square feet (the “Premises”) located in the Building.



 


		C.	Landlord and Tenant desire to amend the Lease upon terms and conditions hereinafter set forth.



 


NOW, THEREFORE. in
consideration of the foregoing facts and circumstances, the mutual covenants and promises contained herein and after good and valuable
consideration, the receipt and sufficiency of which is acknowledged by each of the parties, the parties do hereby agree to the
following:


 


1.           Definitions.
Each capitalized term used in this Amendment shall have the same meaning as is ascribed to such capitalized term in the Lease,
unless otherwise provided for herein.


 


2.           Term.
The term of the Lease is hereby extended for a term commencing on July 1, 2015 and ending on December 31, 2015 (the ‘‘Second
Extended Term”). Tenant shall have no option to renew the Lease following the Second Extended Term.


 


3.           Base
Rent. Base Rent for the Second Extended Term
shall be as follows:


 


	Months	 	Monthly Installment	 	 	Annual	 
	 	 	 	 	 	 	 	 	 
	July 1, 2015 - December 31, 2015	 	$	3,397.35	 	 	$	40,768.20	 



 


4.           No
Defenses. Tenant affirms that, as of the date of execution of this Amendment: (a) no default or breach by Landlord exists under
the Lease; (b) all tenant improvements to be constructed by Landlord prior to the date of this Amendment. if any, are complete
and Tenant has accepted the Premises in “as is, where is” condition as of the date of this Amendment; (c) Landlord
has fully funded or Tenant has waived any unfunded tenant improvement allowances payable under the Lease; and (d) Tenant has no
defenses. offsets or counterclaims that could be asserted in an action by Landlord to enforce Landlord’s remedies under the
Lease.


 




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5.           Broker.
Tenant represents to
Landlord that except for Holt
Lunsford Commercial (the “Broker”). Tenant
has not dealt with any real estate broker,
salesperson or finder in connection with this Amendment. and no other such person initiated
or participated in the negotiation of this Amendment
or is entitled to any commission in connection herewith. Tenant
hereby agrees to indemnify, defend
and hold Landlord, its
property manager and
their respective employees
harmless from and against
any and all liabilities,
claims, demands, actions, damages, costs and expenses (including attorneys’ fees) arising from either (a) a claim for a fee
or commission made by any broker, other than the Broker, claiming to have acted by or on behalf of Tenant in connection
with this Amendment, or (b) a claim of, or right to lien under the statutes of the state in which
the Premises are located relating to real estate broker liens with respect to any such broker retained by Tenant.


 


6.           Submission.
Submission of this
Amendment by Landlord to Tenant for
examination and/or execution shall not in any manner bind Landlord and no obligations on Landlord shall arise under this Amendment
unless and until this Amendment is fully signed and delivered by Landlord and Tenant; provided, however, the execution and delivery
by Tenant of this Amendment to Landlord shall constitute an irrevocable offer by
Tenant of the terms and conditions herein contained,
which offer may not be revoked for thirty (30) days after
such delivery.


 


7.           Miscellaneous.


 


(a)          Time
of Essence. Time is of the essence of this Amendment and each and every term and provision hereof.


 


(b)          Modification.
A modification of any provision herein contained, or any other amendment to this Amendment, shall be effective only if the modification
or amendment is in writing and signed by both Landlord and Tenant.


 


(c)          Successors
and Assigns. This Amendment shall be binding upon and inure to the benefit of the parties hereto and their respective successors
and permitted assigns.


 


(d)          Number
and Gender. As used in this Amendment, the neuter includes masculine and feminine, and the singular includes the plural.


 


(e)          Construction.
Headings at the beginning of each Section and subsection arc solely for the convenience of the parties and are not a part of this
Amendment. Except as otherwise provided in this Amendment, all exhibits referred to herein are attached hereto and are incorporated
herein by this reference. Unless otherwise indicated, all references herein to Articles, Section. subsections, paragraphs, subparagraphs
or provisions are to those in this Amendment. Any reference to a paragraph or Section herein includes all subparagraphs or subsections
thereof. This Amendment shall not be construed as if it had been prepared by only Landlord or Tenant, but rather as if both Landlord
and Tenant had prepared the same. ln the event any portion of this Amendment shall be declared by any court of competent jurisdiction
to be invalid. illegal or unenforceable, such portion shall be deemed severed from this Amendment, and the remaining parts hereof
shall remain in full force and effect, as fully as though such invalid. illegal or unenforceable portion had never been part of
this Amendment.


 




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(f)          Integration
of Other Agreements. This Amendment, the Lease and prior amendments set forth the entire agreement and understanding of the
parties with respect to the matters set forth herein and supersedes all previous written or oral understandings, agreements, contracts.
correspondence and documentation with respect thereto. Any oral representation or modifications concerning this Amendment shall
be of no force or effect.


 


(g)          Duplicate
Originals: Counterparts. This Amendment may be executed in any number of duplicate originals, all of which shall be of equal
legal force and effect. Additionally, this Amendment may be executed in counterparts, but shall become effective only after a counterpart
hereof has been executed by each party; all said counterparts shall, when taken together, constitute the entire single agreement
between parties.


 


(h)          No
Waiver. No failure or delay of either party in the exercise of any right given to such party hereunder shall constitute a waiver
thereof unless the time specified herein for exercise of such right has expired, nor shall any single or partial exercise of any
right preclude other or further exercise thereof or of any other right. No waiver by any party hereto of any breach or default
shall be considered to be a waiver of any other breach or default. The waiver of any condition shall not constitute a waiver of
any breach or default with respect to any covenant, representation or warranty.


 


(i)          Further
Assurances. Landlord and Tenant each agree to execute any and all other documents and to take any further actions reasonably
necessary to consummate the transactions contemplated hereby.


 


(j)          No
Third Party Beneficiaries. Except as otherwise provided herein, no person or entity shall be deemed to be a third party beneficiary
hereof, and nothing in this Amendment, (either expressed or implied) is intended to confer upon any person or entity, other than
Landlord and/or Tenant (and their respective nominees, successors and assigns), any rights, remedies. obligations or liabilities
under or by reason of this Amendment.


 


(k)          Full
Force and Effect. The Lease, as amended hereby, shall continue in full force and effect, subject to the terms and provisions
thereof and hereof. In the event of any conflict between the terms of the Lease and the terms of this Amendment, the terms of this
Amendment shall control.


 




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IN WITNESS WHEREOF
this Amendment is executed as of the day and year aforesaid.


 


	 	LANDLORD:
	 	 
	 	PLAZA Del ORO GREEN, L.P.


 


	 	By:	/s/ Barry P. Marcus
	 	 	Barry P. Marcus, Senior Vice President


 


	 	Date: 6/8/2015
	 	 
	 	TENANT:
	 	 
	 	PLx PHARMA INC.


 


	 	By:	/s/ Ronald R. Zimmerman
	 	 	Ronald R. Zimmerman
	 	 	President


 


	 	Date: 6/1/2015


 




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