SETTLEMENT AGREEMENT AND AMENDMENT TO THE SUPPLY AGREEMENT
  WITNESSETH:
 Whereas,
 Whereas,
 Now, Therefore
 1.
    
    Amendment
 1.1.
    
    Section 3.1 of the Supply Agreement shall be replaced entirely with the following:
 The term of this Agreement shall commence on the Effective Date and shall continue until 31 December 2013 with automatic renewal
for 5 year terms unless either Party gives written notice at least 24 months prior to the expiration of such initial or renewal
term, or unless terminated sooner pursuant to Sections 3.2, 3.3 or 3.4 below (Term).
 1.2.
    
    Section 3.4 of the Supply Agreement shall be replaced entirely with the following:
 This Agreement may be terminated at DIOSYNTHS option following DENDREONs failure to place an Order for at least a nine-month
Campaign prior to the ninetieth (90 th ) day following regulatory approval of the BLA (as defined in Section 3.5), as such
will be or may have been amended.
 In addition, DIOSYNTH may at its option terminate this Agreement if (i) DENDREON reasonably
finds that the complete clinical data from Dendreons IMPACT (IMmunotherapy for Prostate
AdenoCarcinoma Treatment) trial are unfavorable such that commercial manufacture of
Ancillary Component is no longer required and/or reasonably to be expected within the (then
current) Term and accordingly provides DIOSYNTH with a written reasoned statement to that
effect as soon as commercially reasonably possible but in no event later
 
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than within thirty (30) business days from DENDREONs receipt of the respective clinical
data, or (ii) if the respective clinical data referred to under (i) above is not available
to DENDREON on or prior to 1 January 2010 with respect to the complete clinical data, of
which unavailability DENDREON must notify DIOSYNTH within thirty (30) days of such
respective dates.
 1.3
    
    The first sentence of Section 3.7 of the Supply Agreement shall be amended as follows:
 Termination of this Agreement for any reason, including without limitation, the expiry
hereof, shall not relieve (...)
 1.4
    
    Section 4.2(a) of the Supply Agreement shall be replaced entirely with the following:
 Twenty-five percent (25%) of the Campaign Base Price (as set forth in Schedule 3 , based on
the assumption of delivery of the (then current) Minimum Gram Guarantee) upon the later of
(i) receipt of the Order, or (ii) the date which is twelve (12) months before the Order
Campaign Start Date; provided that, solely with respect to DENDREONs Order pursuant to
Section 3.4, DIOSYNTH may invoice DENDREON fifty percent (50%) of the Campaign Base Price,
plus a premium of up to five percent (5%) of the Campaign Base Price (Premium Payment).
For the avoidance of doubt, such Premium Payment is in addition to, and not part of, the
Campaign Base Price payable by DENDREON for such Order.
 1.5
    
    The first two sentences of Section 6.2 of the Supply Agreement:
 DENDREON shall submit to DIOSYNTH (...) through July 1, 2008.
  DIOSYNTH shall be free to fill its intermediate scale cell culture facility with other
customers until an Order pursuant to Section 3.4 is submitted, following which DIOSYNTH will
schedule a Campaign as soon as it has sufficient capacity available.
 1.6
    
    Section 6.3 of the Supply Agreement shall be replaced entirely with the following:
 Any Order by DENDREON shall be submitted to DIOSYNTH at least twelve (12) months prior to
the requested Campaign Start Date that is specified in the Order (such specified Campaign
Start Date, the Order Campaign Start Date).
 1.7
    
    Section 6.4 of the Supply Agreement shall be replaced entirely with the following:
 Without detracting from Section 3.4, each Order shall be for a six (6), nine (9) or twelve (12) month Campaign and shall
specify (i) the Order Campaign Start Date; (ii) the length of
 
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the Campaign; and (iii) the designated carrier for delivery of Ancillary Component.
 1.8
    
    The first sentence of Section 6.6 of the Supply Agreement shall be amended as follows:
 After receiving an Order Acceptance for a Campaign, (...)
 1.9
    
    The first sentence of Section 6.8 of the Supply Agreement shall be amended as follows:
 Following the Order Acceptance, the Order shall be binding on both Parties (...)
 1.10
    
    The first sentence of Section 6.9 of the Supply Agreement shall be amended as follows:
 Except with respect to the Order pursuant to Section 3.4, DENDREON shall have the right to
cancel any Order (...)
 1.11
    
    The first sentence of Section 6.10 of the Supply Agreement shall be amended as follows:
 Except with respect to the Order pursuant to Section 3.4, DENDREON shall have the right to
reduce any Order (...)
 1.12
    
    Section 8.3 of the Supply Agreement shall be replaced entirely with the following:
 Ancillary Component shall be considered non-conforming, and may be rejected by DENDREON, if
it fails to conform to the warranties set forth in section 17.1.
 1.13
    
    Section 14.10 of the Supply Agreement shall be replaced in its entirety by the following
language:
 During the Term of this Agreement, and for a period of 18 months after its expiration or
any termination, except a termination pursuant to Section 3.4, DIOSYNTH shall, at DENDREONs
sole expense, cooperate, subject to the availability of resources in DIOSYNTHs reasonable
determination, in transferring the manufacture and supply of Ancillary Component to another
manufacturing site, including transferring existing inventories of Ancillary Component and
Process Consumables (Technology Transfer). DIOSYNTH shall also provide copies of batch
records, development reports, project correspondence, process validation protocols, process
drawings, product-specific test methods, applicable subcontractor reports, or other Process
Inventions and information related to and reasonably necessary for DENDREON to make
Ancillary Component at an alternate site (which may include know how that otherwise
constitutes Confidential
 
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Information of DIOSYNTH). DIOSYNTH may invoice DENDREON for the time expended in performing
its obligations under this Section 14.10, at a mutually agreed upon hourly rate, plus any
direct expenses. In the event that DIOSYNTH terminates the Supply Agreement pursuant to
Section 3.4 and DENDREON experiences a Change of Control (as defined below) within eighteen
(18) months of the effective date of such termination, DENDREONs successor-in-interest may
provide DIOSYNTH with a written request within such eighteen (18) month period that DIOSYNTH
either: (1) supply the successor-in-interest with Ancillary Compound pursuant to the terms
and conditions of the Supply Agreement or (2) conduct a Technology Transfer pursuant to all
the conditions set forth above (including, but not limited to, the availability of resources
in DIOSYNTHs reasonable determination); provided that, the determination of whether to
supply or conduct a Technology Transfer is within DIOSYNTHs sole discretion. For purposes
of this Section 14.10, Change of Control shall mean a third party acquires all of the
rights required to operate DENDREONs business relating to the Ancillary Compound and the
Supply Agreement by merger, sale of assets or otherwise.
 2.
    
    Settlement  Batch 52.1 As determined by the outcome of the dispute resolution process set forth in Section 8.5
of the Supply Agreement, the Parties agree that Dendreon is not obligated to pay Diosynth
for Batch 5 of Ancillary Component (Batch 5) in accordance with the opinion of an
independent third party expert that Batch 5 did not conform with cGMP.
 3.
    
    Settlement  Freezer Batches
 3.1
    
    DENDREON agrees to immediately upon the execution hereof purchase from DIOSYNTH and take
ownership of all Ancillary Component that form part of Batches 9, 10, 13 (limited to bottles
4, 5 and 6 only; see Section 3.3 below) and 14, all of which were affected by a freezer
deviation, with a total of [ ...]* ([...]*) grams (collectively, the Freezer Batches), at
[...]* percent ([...]*%) of the Campaign Base Price (i.e. [...]*% of USD [...]* per gram = USD
[...]* per gram) (the Provisional Price).3.2
    
    If, at any time, DENDREON directly or indirectly makes use of any part of the Freezer Batches
in humans, whether for clinical or commercial purposes, it shall forthwith notify DIOSYNTH
thereof and within fifteen (15) days of such notification, pay DIOSYNTH a price per gram
utilized equal to USD [...]* per gram.3.3
    
    DENDREON will actively and in a timely manner and at no cost to DIOSYNTH support the sublot
designation of (i) bottles 1, 2 and 3 of Batch 13 (i.e. the bottles of Batch 13 that werent
affected by the Freezer Deviation described above) into Sublot Batch 13 and (ii) bottles 4,
5 and 6 of Batch 13 (i.e. the bottles of Batch 13 that were affected by the Freezer Deviation)
into Sublot Batch 13A.3.4
    
    DENDREON acknowledges and agrees that the Freezer Batches form part of that certain Campaign
that has been performed in 2007, consisting of a total of twenty-three (23) batches
 
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4.
    
    Settlement  Batches 01 and 03
 4.1
    
    Promptly following receipt of DENDREONs documentation supporting such destruction, DIOSYNTH
will destroy the Ancillary Component produced in Batches 01 and 03, at no cost to DENDREON,
and accordingly, DENDREON is not in any way obligated to pay DIOSYNTH for such Ancillary
Component. For the avoidance of doubt, DIOSYNTH is not obligated to replace the said Ancillary
Component.
 5.
    
    Miscellaneous
 5.1
    
    Except to the extent specifically otherwise provided for in this Settlement and Amendment,
the terms of the Supply Agreement (including, for the avoidance of doubt, all definitions used
in this Settlement and Amendment) shall remain unchanged and intact.
  DENDREON CORPORATION
    


    DIOSYNTH RTP INC.By:
    /s/ David Urdal
    

    By:
    /s/ Stephen A. SpearmanTitle: Sr. V.P. and CSO
    

    
    
    Title:      V.P., Development and ProductionDate: Oct. 22, 2008
    

    
    
    Date:   10/24/08By:
    /s/ Henrik EdebackTitle:      VP FinanceDate:   10/24/08 
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