Exhibit 10.4


 


EMPLOYMENT AGREEMENT


 


THIS AGREEMENT made as of the 1st day of October, 2015.


 


BETWEEN:


 


CYNAPSUS THERAPEUTICS INC.


 


(hereinafter called “Cynapsus”)


 


- and -


 


Albert
Agro


 


(hereinafter called the “Executive”)


 


WHEREAS Cynapsus is developing a
sublingual thin filmstrip for the acute rescue of OFF motor symptoms of Parkinson’s disease;


 


AND WHEREAS Cynapsus and the Executive
entered into an original employment agreement dated as of June 1, 2013, as amended on January 1, 2015 and May 13, 2015;


 


AND WHEREAS Cynapsus and the Executive
have agreed to further amend the terms of the employment relationship.


 


NOW THEREFORE THIS AGREEMENT WITNESSES
that in consideration of the mutual covenants and agreements contained herein and other good and valuable consideration, the receipt
and sufficiency of which are hereby acknowledged, the parties covenant and agree as follows:


 


Article
1 - DUTIES


 


1.1                        The
Executive will be the Chief Medical Officer of Cynapsus and will exercise all of the duties and responsibilities of such office
and will perform such other services as the board of directors of Cynapsus (the “Board”) may reasonably request
of the Executive from time to time. The duties of the Executive shall include, but are not limited to, assisting with strategic
planning, clinical research and development, management of the Clinical Advisory Board, clinical and technical publications, regulatory
affairs, intellectual property support, supporting the President and CEO on business development interactions and communicating
with institutional investors and biotechnology analysts. The Executive will report to the President and CEO. In addition, the Executive
shall serve in such other capacities, perform such other duties and exercise such other powers consistent with such activities
as may from time to time be assigned to or vested in him by the Board.


 


1.2                        The
Executive shall devote his full time and attention to the business and affairs of Cynapsus. The Executive shall well and faithfully
serve Cynapsus and use his best efforts to promote the interests and goodwill of Cynapsus. The Executive shall not be precluded
from involvement in other business or commercial opportunities it being understood that such opportunities will take immaterial
time commitments, and provided further that such opportunities are not competitive with the business of Cynapsus or the businesses
of any of its key suppliers.


 






    


     


    

 


1.3                        The
Executive hereby confirms his employment with Cynapsus on the terms and conditions set forth in this Agreement.


 


Article
2 - TERM


 


2.1                        The
parties acknowledge that the Executive has already commenced employment with Cynapsus and that such employment shall continue for
an indefinite term until terminated in accordance with the provisions of this Agreement.


 


Article
3 - COMPENSATION


 


3.1                        For
the performance of his services hereunder and commencing on October 1, 2015, the Executive shall be paid:


 


(a)          A
base salary (the “Base Salary”) of USD$315,000 per annum (or CAD$421,911 per annum, based on the Bank of Canada
USD-CAD noon spot rate of 1.3394 on September 30, 2015), less statutory withholdings, in equal instalments on those dates on which
Cynapsus normally makes salary payments to its employees and in accordance with Cynapsus’ regular practices in that regard.


 


(b)          A
discretionary bonus (the “Annual Bonus”), as determined by the President and CEO and the Board, for each year
of the Executive’s employment hereunder, in an amount equal to 30% of the Base Salary, based on the achievement of agreed-upon
corporate objectives. The Annual Bonus may be increased to up to 40% of the Base Salary, as determined by the Board, based on an
overachievement of goals. The Annual Bonus shall be based on criteria to be approved by the Board, and relayed to the Executive,
which criteria shall reflect the annual corporate goals of Cynapsus and individual goals relating to the Executive’s areas
of oversight.


 


3.2                        The
Executive shall be entitled to annual reviews of his Base Salary and Annual Bonus or any changes to the bonus plan or other forms
of compensation paid or granted to the Executive by Cynapsus as may be determined from time to time by the Board. The Base Salary
will take into account the prevailing market conditions and comparative base salaries as well as changes in Cynapsus’ financial
conditions, market capitalization, growth and corporate size, however measured.


 


3.3                        The
Executive may be granted options to acquire common shares in the capital of Cynapsus at the discretion of the Board and pursuant
to the terms and conditions of Cynapsus’ stock option plan (the “Plan”). Upon a Change of Control (as
defined below) of Cynapsus all stock options will vest immediately upon approval by the Board.


 



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Article
4 - EXPENSES


 


4.1                        It
is understood and agreed that the Executive will incur expenses in connection with performing his duties hereunder. Cynapsus will
reimburse the Executive for all expenses reasonably and properly incurred by the Executive on behalf of Cynapsus, provided that
the Executive provides to Cynapsus receipts acceptable to Cynapsus within a reasonable period after they have been incurred. All
expenses shall be incurred in accordance with agreed-upon corporate policies and budgets.


 


Article
5 - BENEFITS


 


5.1                        During
the period of the employment of the Executive hereunder:


 


(a)          The
Executive shall be entitled to four weeks’ vacation per year to be taken at such times and for such durations as are mutually
acceptable to Cynapsus and the Executive. Up to two weeks’ vacation, which, if not taken in any year, may be taken in any
subsequent year, or the Executive shall be entitled to such vacation pay as may be required pursuant to the Employment Standards
Act, 2000 (Ontario).


 


(b)          The
Executive shall be eligible to participate in the group insurance and benefit plan provided to all senior executives of Cynapsus,
to the extent he qualifies for such benefits. The Executive’s insurance and benefit entitlements shall be subject to and
governed by the terms and conditions of the plan, as amended from time to time.


 


(c)          The
Executive shall be entitled, at the cost of Cynapsus, to the additional benefits set out in Schedule “A” hereto.


 


Article
6 - TERM AND TERMINATION


 


6.1                        Termination
with Cause


 


(a)          Cynapsus
shall be entitled, in its sole discretion, to terminate the employment of the Executive hereunder, without notice or payment in
lieu of notice, for Cause (as hereinafter defined). Cynapsus shall have no obligation to the Executive after the effective date
of termination pursuant to this Section 6.1 except for payment of any Base Salary accrued to the date of termination and any other
amounts which have accrued but not yet been paid in accordance with any benefit plan prior to the date of termination. The Executive
shall not be entitled to receive any bonus whatsoever in the event of termination pursuant to this Section 6.1.


 






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		(b)	For the purposes hereof, “Cause” shall
mean:



 


		(i)	the continued or habitual failure by the Executive to
substantially perform his duties according to the terms of his employment hereunder (other than resulting from the Executive’s
Disability (as hereinafter defined), after Cynapsus has given the Executive reasonable written notice of such failure and a reasonable
opportunity to correct the failure and the Executive fails to substantially remedy the failure;



 


		(ii)	the Executive hereinafter does (or causes or permits
to be done) or hereinafter omits (or causes or permits to be omitted) any act or thing that is materially or significantly
harmful or injurious to Cynapsus or any of its affiliates, monetarily or otherwise;



 


		(iii)	the Executive hereinafter engages in any criminal act
of dishonesty, or any reprehensible behaviour or activity, that could have an adverse effect, either directly or indirectly, on
Cynapsus; or



 


		(iv)	any regulatory sanction that precludes the Executive
from fulfilling his duties under this Agreement.



 


6.2                        Termination
by Cynapsus without Cause


 


(a)          Except
as otherwise provided, Cynapsus shall be entitled in its sole discretion to terminate this Agreement at any time without Cause
upon four months’ plus one additional month’s notice to the Executive for every full year of employment (starting from
June 1, 2013), to a maximum of 12 months, or payment in lieu of notice.


 


(b)          Upon
termination by Cynapsus in accordance with this Section 6.2, Cynapsus shall provide the Executive with written notice or payment
in lieu thereof and an amount equal to the average of the Annual Bonus paid to the Executive in each of the three most recent completed
financial years of Cynapsus (or such fewer number of recent completed financial years if the Executive was employed for less than
the three most recent completed financial years), pro-rated to the effective date of termination (the “Deemed Annual Bonus”),
together with all amounts which the Executive would have been entitled to during such period and a continuation of benefits coverage
during such period in respect of the elements which are permitted to be continued in accordance with the terms of the benefit plan
then in place and applicable laws. Cynapsus shall have the option to pay the amount equal to the Base Salary on its regular payroll
dates or in a lump sum as of the effective date of termination.


 






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6.3                        Termination
by the Executive


 


(a)          The
Executive shall be entitled in his sole discretion to terminate this Agreement for any reason whatsoever at any time upon 60 days’
prior written notice to Cynapsus.


 


(b)          Upon
termination by the Executive in accordance with this Section 6.3, Cynapsus shall have no obligation to the Executive after the
effective date of termination except for payment of any Base Salary accrued to the date of termination, the Deemed Annual Bonus
and any other amounts which have accrued but not yet been paid prior to the date of termination, including any amounts owing in
accordance with any benefit plan.


 


6.4                        Termination
by either Party 


 


		(a)	Either party shall have the right to terminate this Agreement:



 


		(i)	if the other party breaches a term of this Agreement
and such breach is not cured within 10 days after the date of written notice; or



 


		(ii)	if the other party files an assignment in bankruptcy
or a proposal under the Bankruptcy and Insolvency Act (Canada) or if a petition in bankruptcy is filed or presented against
the other party under the Bankruptcy and Insolvency Act (Canada) or comparable legislation and such petition is not discharged
within 90 days, or if a receiver is appointed for all or substantially all of the assets or property of the other party and such
appointment is not contested and the receiver discharged within 30 days.



 


(b)          In
the event of termination by the Executive in accordance with Section 6.4(a)(i) or 6.4(a)(ii), Cynapsus shall pay to the Executive
a lump sum equal to four months plus one additional month for every full year of employment (starting from April 8, 2013) of Base
Salary, to a maximum of 12 months, and the Deemed Annual Bonus, together with all amounts which the Executive would have been entitled
to during such period and a continuation of benefits coverage during such period in respect of the elements which are permitted
to be continued in accordance with the terms of the benefit plan then in place and applicable laws.


 


(c)          In
the event of termination by Cynapsus in accordance with Section 6.4(a)(i) or 6.4(a)(ii), Cynapsus shall have no obligation to the
Executive after the effective date of termination except for payment of any Base Salary accrued to the date of termination and
any other amounts which have accrued but not yet been paid prior to the date of termination, including any amounts owing in accordance
with any benefit plan. The Executive shall not be entitled to receive any bonus whatsoever in the event of termination by Cynapsus
pursuant to Section 6.4(a)(i) or 6.4(a)(ii).


 






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6.5                        Change
of Control


 


(a)          Upon
a Change of Control (as defined below) and for a period of nine months thereafter, in the event of termination of this Agreement
by Cynapsus, or the purchaser or other third party, as the case may be, other than for Cause, or by the Executive for Good Reason
(as defined below), Cynapsus, or the purchaser or other third party, as the case may be, shall pay to the Executive a lump sum
equal to 12 months of Base Salary and the Deemed Annual Bonus, together with all amounts which the Executive would have been entitled
to during such period and a continuation of benefits coverage during such period in respect of the elements which are permitted
to be continued in accordance with the terms of the benefit plan then in place and applicable laws.


 


(b)          For
the purposes hereof, “Change of Control” shall mean:


 


		(i)	a reorganization, amalgamation or merger, or a plan of
arrangement in connection with any of the foregoing, with respect to which all or substantially all of the persons who were the
beneficial owners of the then outstanding voting shares of Cynapsus (“Shares”) immediately prior to such transaction
do not, following such transaction, beneficially own, directly or indirectly, more than 50 percent of the resulting voting
shares;



 


		(ii)	the acquisition of Shares by a person or group of persons
acting in concert as a result of which the acquiror beneficially owns, directly or indirectly, 50 percent or more of the
Shares then outstanding; or



 


		(iii)	the sale to a third party of all or substantially all
of the assets of Cynapsus.



 


(c)          For
the purposes hereof, “Good Reason” shall mean an adverse material change to the terms and conditions of the
Executive’s employment including, but not limited to:


 


		(i)	removal from, or re-assignment of, the Executive’s
position as set forth in Section 1.1 without the agreement of the Executive;



 


		(ii)	a substantive change in the Executive’s duties
as described in Section 1.1 without the agreement of the Executive;



 


		(iii)	a change in the Executive’s reporting relationships,
the result of such change not having a reasonable remedy;



 


		(iv)	relocation of the Executive to a location that is more
than 60 kilometres from Toronto, Ontario without the agreement of the Executive; or



 






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		(v)	a breach by Cynapsus, or the purchaser or other third
party, as the case may be, of Section 6.4(a) hereof which is not cured or remedied within the applicable time periods set forth
therein.



 


6.6                        Termination
for Death or Disability


 


(a)          In
the event of the Executive’s death then this Agreement shall immediately terminate. In the event of the Disability (as hereinafter
defined) of the Executive, Cynapsus shall have the right to terminate this Agreement upon written notice given to the Executive
while the Disability is continuing, which termination shall be effective on the date that the notice is given.


 


(b)          In
the event of the death or Disability of the Executive, Cynapsus shall pay to the Executive an amount equal to the Base Salary accrued
to the date of termination and the Deemed Annual Bonus, together with all amounts which have accrued but not yet been paid prior
to the date of termination, including any amounts owing in accordance with any benefit plan.


 


(c)          For
the purposes hereof, “Disability” shall mean that:


 


		(i)	the Executive has been and continues to be disabled as a result of illness, disease or mental or
physical disability or for other causes beyond his control such that he has been unable or unwilling or has failed to perform or
fulfil all or a material portion of his duties or the requirements of his employment hereunder on a full-time basis for:



 


		(A)	a period of 105 consecutive days or more, or



 


		(B)	an aggregate of 105 days or more in any 12 month period



 


in the opinion
of a qualified medical practitioner who shall be satisfactory to Cynapsus, acting reasonably; or


 


		(ii)	the Executive has been declared by a court of competent jurisdiction to be mentally incompetent
or incapable of managing his affairs.



 


6.7                        Upon
termination of this Agreement by either party for any reason, other than termination by Cynapsus pursuant to Section 6.1 or Section
6.4(a)(i), the Executive shall have the right to exercise any options granted by Cynapsus in accordance with the Plan.


 


6.8                        Upon
termination of this Agreement by Cynapsus pursuant to Section 6.1 or Section 6.4(a)(i), any options granted by Cynapsus or any
unexercised portion thereof shall immediately terminate.


 






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6.9                        Remedies


 


(a)          The
parties confirm that the provisions contained in this Article 6, including the notice and pay in lieu of notice provisions contained
therein, are valid and reasonable and are fair and equitable. The parties agree that upon any termination of the Executive’s
employment by Cynapsus in accordance with the provisions of this Agreement, the Executive shall have no action, cause of action,
claim or demand against Cynapsus or any other person as a consequence of such termination. The Executive further acknowledges and
agrees that the payments and/or notices required pursuant to this Agreement shall be in full satisfaction of all claims for termination
of his employment, including termination pay and/or severance pay pursuant to the Employment Standards Act, 2000 (Ontario)
(as the same may be amended or replaced, from time to time). Except as otherwise provided in this Article 6, the Executive shall
not be entitled to any further termination or severance payments, damages or other compensation whatsoever.


 


(b)          As
a condition precedent to any payment pursuant to this Article 6, the Executive agrees to deliver to Cynapsus contemporaneously
with any such payment, a full and final release of and from all actions or claims in connection therewith in favour of Cynapsus
and their respective directors, officers, employees and agents, in form and substance satisfactory to Cynapsus, acting reasonably.
If the Executive is an officer or director of Cynapsus at the relevant time of termination of his employment in accordance with
the terms hereof, the Executive agrees that contemporaneously with or as soon as is practicable after the termination of his employment
hereunder for any reason whatsoever, he will tender his resignation from any position he may hold as an officer and/or director
of Cynapsus.


 


Article
7 - NON-DISCLOSURE, NON-SOLICITATION AND NON-COMPETITION AGREEMENT


 


7.1                        The
Executive has entered into a Non-Disclosure, Non-Solicitation and Non-Competition Agreement in substantially the same form entered
into between Cynapsus and its other senior officers.


 


7.2                        The
Executive acknowledges and agrees that the employment relationship will be governed by this Agreement and the standards and terms
established by Cynapsus’ policies as they are amended from time to time. The Executive agrees to comply with the terms of
Cynapsus’ current and future policies so long as they are not inconsistent with the provisions of this Agreement. In the
event Cynapsus’ policies or procedures are in conflict with this Agreement the terms of this Agreement shall prevail.


 


Article
8 - NEW AND ADDITIONAL CONSIDERATION


 


8.1                        The
Executive acknowledges and agrees that the increase in the amount of the Executive’s Base Salary constitutes new and additional
consideration in favour of the Executive in connection with the execution and delivery of this Agreement by the Executive.


 






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Article
9 - NOTICES


 


9.1                        Any
notice required or permitted to be given to the Executive shall be sufficiently given if delivered to the Executive personally
or if mailed by registered mail to the Executive’s address last known to Cynapsus or by e-mail at aagro@cynapsus.ca.


 


9.2                        Any
notice required or permitted to be given to Cynapsus shall be sufficiently given if mailed by registered mail to Cynapsus’
head office at its address last known to the Executive.


 


Article
10 - GENERAL


 


		10.1	Severability



 


In the event that any
provision or part of this Agreement shall be deemed void or invalid by a court of competent jurisdiction, the remaining provisions
or parts shall be and remain in full force and effect.


 


		10.2	Binding Effect; Assignment



 


This Agreement shall
enure to the benefit of, and be binding on, the parties and their respective heirs, administrators, executors, successors and permitted
assigns. Cynapsus shall have the right to assign this Agreement to any successor (whether direct or indirect, by purchase,
amalgamation, arrangement, merger, consolidation or otherwise) to all or substantially all of the business and/or assets of Cynapsus
provided that such entity assumes all obligations of Cynapsus hereunder. The Executive shall not assign or transfer, whether absolutely,
by way of security or otherwise, all or any part of the Executive’s rights or obligations under this Agreement.


 


		10.3	Entire Agreement



 


This Agreement, together
with the Non-Disclosure, Non-Solicitation and Non-Competition Agreement dated April 1, 2013, constitutes the entire agreement between
the parties with respect to the employment and appointment of the Executive and any and all other previous agreements, written
or oral, express or implied, between the parties or on their behalf, relating to the employment and appointment of the Executive
by Cynapsus, including but not limited to any previous Consulting Agreements between the Executive and Cynapsus, are hereby terminated
and cancelled and each of the parties releases and forever discharges the other of and from all manner of actions, causes of action,
claims and demands whatsoever, under or in respect of any such agreements so terminated and cancelled.


 


		10.4	Modification and Waiver



 


Any modification to this
Agreement must be in writing and signed by the parties or it shall have no effect and shall be void. No waiver of any breach
or default hereunder shall be considered valid unless in writing, and no such waiver shall be deemed a waiver of any subsequent
breach or default of the same or similar nature.


 






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		10.5	Headings



 


The headings used in
this Agreement are for convenience only and are not to be construed in any way as additions to or limitations of the covenants
and agreements contained in it.


 


		10.6	Governing Law



 


This Agreement shall
be construed in accordance with the laws of the Province of Ontario.


 


		10.7	Time of Essence



 


Time shall be of the
essence of this Agreement.


 


		10.8	Currency



 


All amounts payable pursuant
to this Agreement are expressed in and shall be paid in Canadian currency.


 


		10.9	Legal Advice



 


The Executive acknowledges
that he has had an opportunity to seek independent legal advice prior to their execution of this Agreement. The Executive acknowledges
that he has sought and obtained such independent advice, or has declined seeking such advice, despite having been given the opportunity
to do so.


 


		10.10	Counterparts



 


This Agreement may be
signed in one or more counterparts, each of which so signed shall be deemed to be an original, and such counterparts together shall
constitute one and the same instrument. Notwithstanding the date of execution or transmission of any counterpart, each counterpart
shall be deemed to have the effective date first written above.


 


[Signature Page Follows]


 




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IN WITNESS WHEREOF this Agreement
has been executed by the parties as of the date first written above.


 


	SIGNED, SEALED & DELIVERED	)	 
	in the presence of:	)	 
	 	)	 
	 	)	 
	 	)	 
	/s/ Susan Thompson	)	/s/ Albert Agro
	Witness	 	ALBERT AGRO
	 	 	 
	 	 	CYNAPSUS THERAPEUTICS INC.
	 	 	 	 
	 	 	Per:	/s/ Anthony Giovinazzo
	 	 	 	Authorized Signing Officer
	 	 	 	 
	 	 	Per:	/s/ Andrew Williams
	 	 	 	Authorized Signing Officer


 




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SCHEDULE “A”


 


Additional Benefits


 


The Executive will be entitled to receive the following
additional benefits:


 


		1.	Six personal days, with pay, including sick days.