Exhibit 21



Pharmaceutical Product Development, Inc., and Subsidiaries

Subsidiaries



The subsidiaries of
Pharmaceutical Product Development, Inc., as of February 15, 2005, are as follows:



|    |  |                                                      |  |                                              
|--- |  | ---------------------------------------------------- |  | ---------------------------------------------
|    |  | Name of Subsidiary                                   |  | Jurisdiction of Incorporation or Organized in
|1.  |  | Applied Bioscience International LLC                 |  | Delaware                                     
|2.  |  | Belmont Research, Inc.                               |  | Massachusetts                                
|3.  |  | CSS Informatics, Inc.                                |  | California                                   
|4.  |  | Medical Research Laboratories International, LLC     |  | Kentucky                                     
|5.  |  | Piedmont Research Center, LLC                        |  | North Carolina                               
|6.  |  | PPD Aeronautics, LLC                                 |  | North Carolina                               
|7.  |  | PPD Virtual, Inc.                                    |  | North Carolina                               
|8.  |  | APBI Finance Corporation                             |  | Delaware                                     
|9.  |  | APBI Holdings, LLC                                   |  | North Carolina                               
|10. |  | Development Partners, LLC                            |  | Delaware                                     
|11. |  | PPD GP, LLC                                          |  | Delaware                                     
|12. |  | PPD Holdings, LLC                                    |  | Delaware                                     
|13. |  | PPD UK Holdings Ltd.                                 |  | United Kingdom                               
|14. |  | SARCO, LLC                                           |  | Delaware                                     
|15. |  | Genupro, Inc.                                        |  | North Carolina                               
|16. |  | PPD Development, LP                                  |  | Texas                                        
|17. |  | ATP, LLC                                             |  | North Carolina                               
|18. |  | PPD Online Marketing and Education, Inc.             |  | Delaware                                     
|19. |  | PPD Medical Device, Inc.                             |  | Delaware                                     
|20. |  | Pharmaco Investments Inc.                            |  | Delaware                                     
|21. |  | PPD International Holdings, Inc.                     |  | Delaware                                     
|22. |  | PPD France SNC                                       |  | France                                       
|23. |  | PPD Scandinavia AB                                   |  | Sweden                                       
|24. |  | Pharmaceutical Product Development Spain SL          |  | Spain                                        
|25. |  | PPD do Brazil-Suporte a Pesquisa, LTDA               |  | Brazil                                       
|26. |  | PPD Argentina, SA                                    |  | Argentina                                    
|27. |  | PPD International Holdings, Inc. Y Compania Limitada |  | Chile                                        
|28. |  | PPD South Africa                                     |  | South Africa                                 
|29. |  | PPD Canada, Ltd.                                     |  | Canada                                       
|30. |  | PPD Australia Pty Limited                            |  | Australia                                    
|31. |  | PPD International Holdings GmbH                      |  | Germany                                      
|32. |  | PPD Germany GmbH                                     |  | Germany                                      
|33. |  | PPD Poland Sp. Zo.O                                  |  | Poland                                       
|34. |  | PPD Czech Republic, S.r.o.                           |  | Czech Republic                               
|35. |  | PPD Germany GmbH & Co. KG                            |  | Germany                                      
|36. |  | PPD Hungary R&D, Ltd.                                |  | Hungary                                      
|37. |  | PPD Italy S.r.l                                      |  | Italy                                        
|38. |  | PPD Mexico S.A. de C.V.                              |  | Mexico                                       
|39. |  | PPD Development (Thailand) Co., Ltd.                 |  | Thailand                                     
|40. |  | PPD Japan, K.K.                                      |  | Japan                                        
|41. |  | PPD Global Ltd.                                      |  | United Kingdom                               
|42. |  | Clinical Technology Centre International, Limited    |  | United Kingdom                               



---

|    |  |                                                               |  |               
|--- |  | ------------------------------------------------------------- |  | --------------
|43. |  | Cambridge Applied Nutrition Toxicology and Bioscience Limited |  | United Kingdom
|44. |  | Clinical Science Research International, Ltd.                 |  | United Kingdom
|45. |  | Leicester Clinical Research Centre, Ltd.                      |  | United Kingdom
|46. |  | Chelmsford Clinical Trials Unit, Ltd.                         |  | United Kingdom
|47. |  | Gabbay, Ltd.                                                  |  | United Kingdom
|48. |  | Data Analysis & Research, Ltd.                                |  | United Kingdom
|49. |  | Medical Research Laboratories International, BVBA             |  | Belgium       
|50. |  | PPD Development (S) Pte Ltd                                   |  | Singapore     
|51. |  | PPD Development (HK) Limited                                  |  | Hong Kong     
|52. |  | Propharma CRO Pty Ltd                                         |  | Australia     
|53. |  | PPD (Netherlands) B.V.                                        |  | Netherlands   
|54. |  | PPD Pharmaceutical Development India Private Limited          |  | India         
|55. |  | Surromed LLC                                                  |  | North Carolina
|56. |  | River Ventures LLC                                            |  | North Carolina



Subsidiaries 1, 2, 3, 4, 5, 6, 7 and
55 are wholly-owned subsidiaries of Pharmaceutical Product Development, Inc.



Subsidiaries 8, 9, 10, 11, 12, 13 and 14 are wholly-owned subsidiaries of Subsidiary 1.



Subsidiary 15 is a wholly-owned subsidiary of Subsidiary 7.



Subsidiary 16 is owned 99.9% by Subsidiary 12 and 0.1% by Subsidiary 11.



Subsidiaries 17, 18, 19, 20, 21 and 56 are wholly-owned subsidiaries of Subsidiary 16.



Subsidiaries 23, 24, 25, 28, 29, 30, 31, 37, 39 and 40 are wholly-owned subsidiaries of Subsidiary 21.



Subsidiary 22 is owned 99.9% by Subsidiary 21 and 0.1% by Subsidiary 1.



Subsidiary 26 is owned 99.99% by Subsidiary 21 and 0.01% by Subsidiary 1.



Subsidiary 27 is owned 99% by Subsidiary 21 and 1% by Subsidiary 1.



Subsidiaries 32, 33 and 34 are wholly-owned subsidiaries of Subsidiary 31.



Subsidiary 35 is owned 72% by Subsidiary 31 and 28% by Subsidiary 32.



Subsidiary 36 is owned 96.7% by Subsidiary 31 and 3.3% by Subsidiary 21.



Subsidiary 38 is owned 99% by Subsidiary 21 and 1% by Subsidiary 16.



Subsidiaries 41, 45, 46, 47, 48, 50, 53 and 54 are wholly-owned subsidiaries of Subsidiary 13.



Subsidiaries 42, 43 and 44 are wholly-owned subsidiaries of Subsidiary 41.



Subsidiary 49 is 99.9% owned by Subsidiary 13 and 0.1% by Subsidiary 41.



Subsidiary 51 is 50% owned by Subsidiary 50 and 50% by Subsidiary 1.



Subsidiary 52 is a wholly-owned subsidiary of Subsidiary 50.