Exhibit 21

Pharmaceutical Product Development, Inc., and Subsidiaries

Subsidiaries

The subsidiaries of Pharmaceutical Product Development, Inc., as of February 13, 2009, are as follows:



|    |  |                                                           |  |                                             
|--- |  | --------------------------------------------------------- |  | --------------------------------------------
|    |  | Name of Subsidiary                                        |  | Jurisdiction of IncorporationOr Organized in
|1.  |  | Applied Bioscience International, LLC                     |  | Delaware                                    
|2.  |  | CSS Informatics, Inc.                                     |  | California                                  
|3.  |  | PPD Global Central Labs, LLC                              |  | Kentucky                                    
|4.  |  | Piedmont Research Center, LLC                             |  | North Carolina                              
|5.  |  | PPD Aeronautics, LLC                                      |  | North Carolina                              
|6.  |  | PPD Virtual, Inc.                                         |  | North Carolina                              
|7.  |  | APBI Finance Corporation                                  |  | Delaware                                    
|8.  |  | APBI Holdings, LLC                                        |  | North Carolina                              
|9.  |  | Development Partners, LLC                                 |  | Delaware                                    
|10. |  | PPD GP, LLC                                               |  | Delaware                                    
|11. |  | PPD Holdings, LLC                                         |  | Delaware                                    
|12. |  | PPD UK Holdings Ltd                                       |  | United Kingdom                              
|13. |  | Genupro, Inc.                                             |  | North Carolina                              
|14. |  | PPD Development, LP                                       |  | Texas                                       
|15. |  | ATP, LLC                                                  |  | North Carolina                              
|16. |  | Pharmaco Investments, Inc.                                |  | Delaware                                    
|17. |  | PPD International Holdings, Inc.                          |  | Delaware                                    
|18. |  | PPD France SNC                                            |  | France                                      
|19. |  | PPD Scandinavia AB                                        |  | Sweden                                      
|20. |  | Pharmaceutical Product Development Spain SL               |  | Spain                                       
|21. |  | PPD do Brasil-Suporte a Pesquisa Clinica Ltda.            |  | Brazil                                      
|22. |  | PPD Argentina, S.A.                                       |  | Argentina                                   
|23. |  | PPD International Holdings, Inc. Y Compania Limitada      |  | Chile                                       
|24. |  | Pharmaceutical Product Development South Africa (Pty) Ltd |  | South Africa                                
|25. |  | PPD Canada, Ltd.                                          |  | Canada                                      
|26. |  | PPD Australia Pty Ltd                                     |  | Australia                                   
|27. |  | PPD International Holdings GmbH                           |  | Germany                                     
|28. |  | PPD Germany GmbH                                          |  | Germany                                     
|29. |  | PPD Poland Sp..Zo.o                                       |  | Poland                                      
|30. |  | PPD Czech Republic, s.r.o.                                |  | Czech Republic                              
|31. |  | PPD Germany GmbH & Co KG                                  |  | Germany                                     
|32. |  | PPD Hungary Research & Development Limited                |  | Hungary                                     
|33. |  | PPD Italy S.r.l.                                          |  | Italy                                       
|34. |  | PPD Mexico, S.A. de C.V.                                  |  | Mexico                                      
|35. |  | PPD Development (Thailand) Co., Ltd                       |  | Thailand                                    
|36. |  | PPD Japan K.K.                                            |  | Japan                                       
|37. |  | PPD Global, Ltd                                           |  | United Kingdom                              
|38. |  | Clinical Technology Centre International Ltd              |  | United Kingdom                              
|39. |  | Cambridge Applied Nutrition Toxicology & Biosciences Ltd  |  | United Kingdom                              
|40. |  | Clinical Science Research International, Ltd              |  | United Kingdom                              
|41. |  | Leicester Clinical Research Centre, Ltd                   |  | United Kingdom                              
|42. |  | Chelmsford Clinical Trials Unit, Ltd                      |  | United Kingdom                              
|43. |  | Gabbay Ltd                                                |  | United Kingdom                              
|44. |  | Data Analysis & Research (DAR) Ltd                        |  | Scotland                                    



---

|    |  |                                                                              |  |                
|--- |  | ---------------------------------------------------------------------------- |  | ---------------
|45. |  | PPD Global Central Labs BVBA                                                 |  | Belgium        
|46. |  | PPD Development (S) Pte Limited                                              |  | Singapore      
|47. |  | PPD Development (HK) Limited                                                 |  | Hong Kong      
|48. |  | PPD (Netherlands) BV                                                         |  | Netherlands    
|49. |  | PPD Pharmaceutical Development India Private Limited                         |  | India          
|50. |  | PPD Biomarker Discovery Sciences, LLC                                        |  | North Carolina 
|51. |  | River Ventures LLC                                                           |  | North Carolina 
|52. |  | PPD Slovak Republic s.r.o.                                                   |  | Slovak Republic
|53. |  | PPD Peru S.A.C.                                                              |  | Peru           
|54. |  | PPD Vaccines and Biologics, LLC                                              |  | Pennsylvania   
|55. |  | PPD Pharmaceutical Development (Beijing) Co., Ltd                            |  | China          
|56. |  | Greenbird Limited                                                            |  | Cyprus         
|57. |  | PPD Development Ireland Ltd                                                  |  | Ireland        
|58. |  | Limited Liability Company PPD Development (Smolensk)                         |  | Russia         
|59. |  | PPD Global Central Labs (S) Pte. Ltd.                                        |  | Singapore      
|60. |  | Limited Liability Company Contract Research Organization Innopharm  Ukraine |  | Ukraine        

Subsidiaries 1, 2, 3, 4, 6 and 54 are wholly-owned subsidiaries of Pharmaceutical Product Development, Inc.

Subsidiaries 10 and 11 are wholly-owned subsidiaries of Subsidiary 1.

Subsidiary 13 is a wholly-owned subsidiary of Subsidiary 6.

Subsidiary 14 is owned 99.9% by Subsidiary 11 and 0.1% by Subsidiary 10.

Subsidiaries 5, 7, 8, 15, 16, 17, 50 and 51 are wholly-owned subsidiaries of Subsidiary 14.

Subsidiaries 9, 12, 19, 24, 25, 26, 27, 33, 36 and 57 are wholly-owned subsidiaries of Subsidiary 17.

Subsidiary 18 is
owned 99.999% by Subsidiary 17 and 0.001% by Subsidiary 1.

Subsidiary 20 is owned 99.231 % by Subsidiary 17 and 0.769% by Subsidiary 14.

Subsidiary 21 is owned 99.99% by Subsidiary 17 and 0.01% by Pharmaceutical Product Development, Inc.

Subsidiary 22 is owned 95% by Subsidiary 17 and 5% by Subsidiary 1.

Subsidiary 23 is owned 99% by Subsidiary 17 and 1% by
Subsidiary 1.

Subsidiaries 28 and 29 are wholly-owned subsidiaries of Subsidiary 27.

Subsidiary 30 is owned 97.78% by Subsidiary 27 and 2.22% by Subsidiary 17.

Subsidiary 31 is owned 72% by Subsidiary 27 and
28% by Subsidiary 28.

Subsidiary 32 is owned 96.67% by Subsidiary 27 and 3.33% by Subsidiary 17.

Subsidiary 34 is owned 99.99% by Subsidiary 17 and 0.01% by Subsidiary 14.

Subsidiary 35 is owned 99.99% by Subsidiary 17 and 1 share is held by each of Subsidiary 46, Subsidiary 47, Subsidiary 12,

Subsidiary 37, and 2
individuals.

Subsidiaries 37, 41, 42, 43, 44, 46, 48 and 59 are wholly-owned subsidiaries of Subsidiary 12.

Subsidiary 38 is owned 99% by Subsidiary 37 and 1% by Subsidiary 12.

Subsidiary 40 is a wholly-owned subsidiary of Subsidiary 37.

Subsidiary 39 is owned 50% by Subsidiary 12 and 50% by Subsidiary 37.

Subsidiary 45 is 99.9% owned by Subsidiary 12 and .1% by Subsidiary 37.

Subsidiary 47 is 50% owned by Subsidiary 46 and 50% by Subsidiary 1.

Subsidiary 48 is a wholly-owned subsidiary of Subsidiary 12.

Subsidiary 52 is owned 85% by Subsidiary 12 and 15% by Subsidiary 37.

Subsidiary 53 is owned 99% by Subsidiary 17 and 1% by Subsidiary 1.

Subsidiary 55 is a wholly-owned subsidiary of Subsidiary 46.

Subsidiary 56 is owned 99.95% by Subsidiary 12 and 0.05% by Subsidiary 48.

Subsidiary 58 is a wholly-owned subsidiary of Subsidiary 56.

Subsidiary 60 is a wholly-owned subsidiary of Subsidiary 58.