SAT Report

PMN Number: P-14-0231

SAT Date: 1/14/2014

Print Date: 7/7/2014

Related cases:

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 3 2

 Persistence Bioaccum Toxicity Comments

1 1 3 PMN

3 2 3 Small Components

3 2 3 Deg Pdts

Exposure Based Review:

Health: No

Ecotox: Yes

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: All releases to water

Fate: ;

Keywords:

 Keywords: ENDOCRINE DISRUPTION; DEVEL; REPRO; SENS-ASTHMA; 

THYMUS; SPLEEN; LYMPH NODES; BONE MARROW; IMMUNO; SYSTEMIC; NEURO; 

MUTA; ASTHMA; SENS-S; AQUATOX

Summary of Assessment:

 Fate:

Fate Summary: P-14-0231

FATE: 

Liquid with MP < 25 C (E)

S = 4.4 mg/L at 25 C (Analog)

VP < 1.0E-6 torr at 25 C (E)

BP = 216 C (Analog)

H < 1.00E-8 (E)

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POTW removal (%) = 90 via sorption and possible partial biodeg; Analogs: OECD 301B(Mod 

Sturm CO2 ev): 71%/28d; Analog: No method ID (Gastric Hydrolysis): t1/2(pH ~1-2):<5min.

Time for complete ultimate aerobic biodeg wk-mo

Sorption to soils/sediments = v.strong

PBT Potential: PMN P1B1; Deg Pdt and Small Components P3B2

*CEB FATE: Migration to ground water = negl

 Health:

 Health Summary: Absorption of LMW components will be moderate all 

routes based on analogs and physical/chemical properties; absorption of HMW components will 

be poor all routes based on analogs and physical/chemical properties; expected to hydrolyze in 

the acid of the stomach based on an analogue. 

Concern for immunotoxicity based on with NOAEL = 0.25 mg/kg/d; 

IRIS RfD = 3E-5 mg/kg/d based on immunotoxicity from concern for 

neurotoxicity based on data for ; concern for developmental and 

reproductive toxicity based on data for compounds; rabbits are the most sensitive 

species, see below, concern for endocrine disruption based on analogs and fact that target organs 

are either endocrine or endocrine related; concern for systemic toxicity based on data for 

 with NOEL = 1.0 mg/kg/d; concern for mutagenicity based on data for 

analogs; concern for sensitization and asthma based on analogs.

Other concerns as identified in the New Chemicals Csategory for compounds: Tested 

 have been shown to be from moderately irritating to corrosive to the skin and eyes. 

Acute oral and dermal exposures can result in systemic effects, primarily neurotoxicity. 

Concerns for immunotoxicity are based on data on . During a 13-week 

oral study in rats using effects to the thymus, spleen, 

lymph nodes, and bone marrow were observed. A No-Observable-Adverse-Effect-Level 

(NOAEL) of 1.6 mg/kg/d was derived from this study. During a 17-month feeding study in rats 

using , immunoglobulin E (IgE) titers were reduced, as well as the 

activity of natural killer cells in the spleen, and there was reduced macrophage function. A 

NOAEL of 0.025 mg/kg/d was derived from this study. Based on the immunotoxicity end-point, 

an oral reference dose for chronic exposure (RfD) for of 3 x 10-5 mg/kg/d (IRIS 

01/01/89) has been derived. are well known neurotoxins, with the 

 being more toxic than the mono- and di-substituted compounds. There are 

also concerns for asthma and skin sensitization. 

 Test Data: Analog 

 Test Data Submitted with PMN: 

 Negative in Salmonella and E. coli with and without activation. 

 LD50 > 300 and < 2000 mg/kg in rats (no deaths at 300 mg/kg, 2 death and 2 moribund rats out 

of 6 total rats at 200 mg/kg) 

 28-day Oral, blood changes at 150 and 300 mg/kg/day and in males and females at 500 mg/kg, 

diuretic effect (clinical chemistry, urianalysis) at 150, 300 and 500 mg/kg. Macroscopic changes 

in liver

 of males and female rats without concurrent microscopic changes at 500 mg/kg/day, NOEL 

= 50 mg/kg/day.

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 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 19

daphnid 48-h LC50 380

green algal 96-h EC50 21

fish _ chronic value 0.52

daphnid _ chronic 

value

250

algal _ chronic 

value

2.1

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for compounds; SAR chemical 

class = compounds with 14.3% ; MW 832; liquid with mp unknown (P); S = 4.4 mg/L at 

20 C (P); pH7; effective concentrations based on 100% active ingredients and mean measured 

concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

52

SARs

SAR Class

Ecotox Category 

Ecotox Factors Comments: 

 SAT Chair: Doritza Pagan-Rodriguez

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