### SAT Report PMN Number: P-14-0231 SAT Date: 1/14/2014 Print Date: 7/7/2014

Related cases :

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 3 2

Persistence Bioaccum Toxicity Comments 1 1 3 PMN 3 2 3 Small Components 3 2 3 Deg Pdts

Exposure Based Review : Health: N o Ecotox: Yes

Routes of exposure : Health: Dermal Drinking Water Inhalation Ecotox: All releases to water Fate: ;
Keywords : Keywords: ENDOCRINE DISRUPTION; DEVEL; REPRO; SENS-ASTHMA; THYMUS; SPLEEN; LYMPH NODES; BONE MARROW; IMMUNO; SYSTEMIC; N EURO; MUTA; ASTHMA; SENS-S; AQUATOX
Summary of Assessment :

Fate : Fate Summary: P-14-0231 FATE: Liquid with MP < 25 C (E) S = 4.4 mg/L at 25 C (Analog) VP < 1.0E-6 torr at 25 C (E) BP = 216 C (Analog) H < 1.00E-8 (E)POTW removal (%) = 90 via sorption and possible partial biodeg; Analogs: OECD 301B(Mod Sturm CO2 ev): 71%/28d; Analog: N o method ID (Gastric Hydrolysis): t1/2( p H ~1-2):<5min. Time for complete ultimate aerobic biodeg wk-mo Sorption to soils/sediments = v.strong PBT Potential: PMN P1B1; Deg Pdt and Small Components P3B2 *CEB FATE: Migration to ground water = negl

Health : Health Summary: Absorption of LMW components will be moderate all routes based on analogs and physical/chemical properties; absorption of HMW components will be poor all routes based on analogs and physical/chemical properties; expected to hydrolyze in the acid of the stomach based on an analogue.

Concern for immunotoxicity based on with NOAEL = 0.25 mg/kg/d; IRIS RfD = 3E-5 mg/kg/d based on immunotoxicity from concern for neurotoxicity based on data for ; concern for developmental and reproductive toxicity based on data for compounds; rabbits are the most sensitive species, see below, concern for endocrine disruption based on analogs and fact that target organs are either endocrine or endocrine related; concern for systemic toxicity based on data for with NOEL = 1.0 mg/kg/d; concern for mutagenicity based on data for analogs; concern for sensitization and asthma based on analogs.

Other concerns as identified in the New Chemicals Csategory for compounds: Tested have been shown to be from moderately irritating to corrosive to the skin and eyes. Acute oral and dermal exposures can result in systemic effects, p rimarily neurotoxicity. Concerns for immunotoxicity are based on data on . During a 13-week oral study in rats using effects to the thymus, spleen, lymph nodes, and bone marrow were observed. A No-Observable-Adverse-Effect-Level ( N OAEL) of 1.6 mg/kg/d was derived from this study. During a 17-month feeding study in rats using , immunoglobulin E (IgE) titers were reduced, as well as the activity of natural killer cells in the spleen, and there was reduced macrophage function. A N OAEL o f 0.025 mg/kg/d was derived from this study. Based on the immunotoxicity end- p oint, an oral reference dose for chronic exposure (RfD) for of 3 x 10-5 mg/kg/d (IRIS 01/01/89) has been derived. are well known neurotoxins, with the being more toxic than the mono- and di-substituted compounds. There are also concerns for asthma and skin sensitization. Test Data: Analog Test Data Submitted with PMN: N egative in Salmonella and E. coli with and without activation. LD50 > 300 and < 2000 mg/kg in rats (no deaths at 300 mg/kg, 2 death and 2 moribund rats out of 6 total rats at 200 mg/kg) 28-day Oral, blood changes at 150 and 300 mg/kg/day and in males and females at 500 mg/kg, diuretic effect (clinical chemistry, urianalysis) at 150, 300 and 500 mg/kg. Macroscopic changes in liver of males and female rats without concurrent microscopic changes at 500 mg/kg/day, N OEL = 50 mg/kg/day.Ecotox :
Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 19 daphnid 48-h LC50 380 green algal 96-h EC50 21 fish

_ chronic value 0.52 daphnid

_ chronic value 250

algal

_ chronic value 2.1

Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for compounds; SAR chemical class = compounds with 14.3% ; MW 832; liquid with mp unknown (P); S = 4.4 mg/L at 20 C (P); p H7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 52

SARs SAR Class Ecotox Category

Ecotox Factors Comments:

SAT Chair: Doritza Pagan-Rodriguez