Exhibit 10.25

ACCELRYS, INC.        EMPLOYMENT AGREEMENT

This EMPLOYMENT AGREEMENT (the "Agreement") is entered into as of September 13, 2004 and effective as of
the Effective Time as defined in the Merger Agreement (as defined below) (the "Effective Date") by and between Accelrys, Inc. (the
"Company") and Mathew Hahn ("Employee").

WHEREAS,
prior to the Effective Date, Employee was the Chief Executive Officer of Scitegic, Inc. ("Scitegic");

WHEREAS,
at the Effective Time (as defined in the Merger Agreement), Nashville Acquisition Company, a California corporation ("Merger
Sub"), will be merged with and into Scitegic (the "Merger") pursuant to that certain Agreement and Plan of Merger and
Reorganization, dated as of September 13, 2004, by and among the Company, Merger Sub, Scitegic, Employee and the other parties thereto (the "Merger
Agreement");

WHEREAS,
as a condition precedent to its obligations pursuant to the Merger Agreement, the Company has required the execution and delivery of this Agreement by Employee; and

WHEREAS,
following the Effective Time, the Company desires to retain Employee's services to facilitate the conduct of the Company's business.

NOW,
THEREFORE, in consideration of the premises and mutual covenants herein and for other good and valuable consideration, the parties agree as follows:

1.Position and Duties.



2.Base Salary.From the Effective Date through March 31, 2005, the Company shall pay Employee a base
salary at the annual rate of $209,000, payable in regular installments in accordance with the Company's usual payment practices and be subject to the usual, required withholding. From April 1,
2005 to the end of the Employment Term, the Company shall pay Employee a base salary at the annual rate of $230,000, subject to any increase or decrease as determined by the Company,

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payable
in regular installments in accordance with the Company's usual payment practices and be subject to the usual, required withholding;provided, howeverthat
from April 1, 2005 through the earlier of (i) the end of the Employment Term or (ii) September 30, 2006,
Employee's base salary shall be no less than an annual rate of $230,000. Employee's annual base salary, as in effect from time to time, is hereinafter referred to as the "Base
Salary."

3.Annual Bonus.



4.Stock Option.Subject to Board approval, Employee will be granted a stock option to purchase 50,000 shares of
the Company's Common Stock at an exercise price equal to the then current fair market value per share, as reflected in the closing price quoted on the Nasdaq Stock Market on the date of grant (the
"Option"). The Option will vest twenty five percent twelve months after the Effective Date, and as to 1/48th of the shares subject to the Option monthly
thereafter, so that the Option will be fully vested and exercisable four (4) years from the date of grant, subject to Employee's continued service to the Company through each of the relevant
vesting dates. The Option will be subject to the terms, definitions and provisions of the Company's Employee New Hire Stock Plan and the stock option agreement by and between Employee and the Company
(the "Option Agreement"), which documents are incorporated herein by reference. In addition, the Company will request, as soon as administratively
possible, approval of its Board of Directors, to the extent necessary, to permit Employee to exercise the Option and sell shares thereunder pursuant to and in compliance with
Rule 10b5-1 promulgated under the Securities Exchange Act of 1934, as amended, if possible.

5.Employee Benefits.During the Employment Term, Employee shall be eligible to participate in and receive
benefits under the Company's employee benefit plans (other than annual bonus and incentive plans) as in effect from time to time (collectively "Employee
Benefits"), on the same basis as those benefits are generally made available to other executives of the Company.

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6.Business Expenses.During the Employment Term, reasonable business expenses incurred by Employee in the
performance of Employee's duties hereunder shall be promptly reimbursed by the Company in accordance with Company policies.

7.Termination.Employee's employment hereunder may be terminated by either party at any time and for any
reason;provided,however, that Employee will be required to give the Company at least 60 days
advance written notice of any resignation of Employee's employment. Notwithstanding any other provision of this Agreement, the provisions of this Section 7 shall exclusively govern Employee's
rights upon termination of employment with the Company and its affiliates.



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8.Confidentiality; Intellectual Property; Protective Covenants.Employee agrees to enter into (i) the
Company's standard Confidential Information and Invention Assignment Agreement (the "Confidential Information Agreement") and (ii) a Protective
Covenant Agreement (the "Protective Covenant Agreement") upon commencing employment hereunder.

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9.Arbitration.



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10.Miscellaneous.



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[Remainder of page intentionally left blank.]

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IN
WITNESS WHEREOF, the parties hereto have duly executed this Agreement as of the day and year first above written.

| |  | ACCELRYS, INC.           
| |  | -------------------------
| |  | By:                      
| |  |                          
| |  | Name:                    
| |  |                          
| |  | Title:                   
| |  |                          
| |  | EMPLOYEE                 
| |  | /s/MATHEW HAHNMathew Hahn
| |  |                          
| |  |                          
| |  |                          

ACCELRYS, INC.
SIGNATURE PAGE TO EMPLOYMENT AGREEMENT

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