**Exhibit 31.1**

**CERTIFICATIONS**

I, Patrick P.Fourteau, certify that:

1.                                       Ihave reviewed this quarterly report on Form 10-Q of Sciele Pharma, Inc.;

2.                                       Basedon my knowledge, this report does not contain any untrue statement of amaterial fact or omit to state a material fact necessary to make the statementsmade, in light of the circumstances under which such statements were made, notmisleading with respect to the period covered by this report;

3.                                       Basedon my knowledge, the financial statements, and other financial informationincluded in this report, fairly present in all material respects the financialcondition, results of operations and cash flows of the registrant as of, andfor, the periods presented in this report;

4.                                       Theregistrant’s other certifying officer(s) and I are responsible for establishingand maintaining disclosure controls and procedures (as defined in Exchange ActRules 13a-15(e) and 15d-15(e)) for the registrant and have:
|        |   | i.     |   | Designed such disclosure controls and procedures, or  caused such disclosure controls and procedures to be designed under our  supervision, to ensure that material information relating to the registrant,  including its consolidated subsidiaries, is made known to us by others within  those entities, particularly during the period in which this report is being  prepared;                              |
|--------|--------|--------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   |   |   |   |                                                                                                                                                                                                                                                                                                                                                                                                             |
|   |   | ii.    |   | Designed such internal controls over financial  reporting, or caused such internal controls over financial reporting to be  designed under our supervision, to provide reasonable assurance regarding the  reliability of financial reporting and the preparation of financial  statements for external purposes in accordance with generally accepted  accounting principles;                                   |
|   |   |   |   |                                                                                                                                                                                                                                                                                                                                                                                                             |
|   |   | iii.   |   | Evaluated the effectiveness of the registrant’s disclosure  controls and procedures and presented in this report our conclusions about  the effectiveness of the disclosure controls and procedures, as of the end of  the period covered by this report based on such evaluation; and                                                                                                                      |
|   |   |   |   |                                                                                                                                                                                                                                                                                                                                                                                                             |
|   |   | iv.    |   | Disclosed in this report any change in the  registrant’s internal control over financial reporting that occurred during  the registrant’s most recent fiscal quarter (the registrant’s fourth fiscal  quarter in the case of an annual report) that has materially affected, or is  reasonably likely to materially affect, the registrant’s internal control  over financial reporting; and |

 

5.                                       Theregistrant’s other certifying officer(s) and I have disclosed, based on ourmost recent evaluation of internal control over financial reporting, to theregistrant’s auditors and the audit committee of the registrant’s board ofdirectors (or persons performing the equivalent functions):
|        |   | i.     |   | All significant deficiencies and material weaknesses  in the design or operation of internal control over financial reporting which  are reasonably likely to adversely affect the registrant’s ability to record,  process, summarize and report financial information; and |
|--------|--------|--------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   |   |   |   |                                                                                                                                                                                                                                                                              |
|   |   | ii.    |   | Any fraud, whether or not material, that involves  management or other employees who have a significant role in the registrant’s  internal controls over financial reporting.                                                                                                |

 
|                 |     |     |     |                                    |
|----------------------|----------|----------|----------|-----------------------------------------|
| Date: August 8, 2006 |     |     |     | /s/ PATRICK P. FOURTEAU,                |
|                 |     |     |     | Patrick P. Fourteau,                    |
|                 | * * | * * | * * | *Chief Executive Officer and President* |

 

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