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Jllilllat!gl?: -1T1':r:>'A7:.t-7L.Cf;ouu:'llj;f1) Vol. 'L No. 4, 22(1981) 

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J. K. Haseman et a!. : JNCL Vol. 75 November(1985) 

- 5---

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1 Table 2. Summary of histopatholor.ical finrlinr.s in mice fed IIBCD for 18 months 

Sex Male Female 

Organs killed or died killed died k i !led died · 

Findings group c L M H c L M ll c L M H c L M 

No. of animals examined 45 47 45 dr 

.. J 5 3 5 5 48 49 49 49 2 1 1 

Lung f 

adenocarcinoma 

adenoma 5 

0 1 0 0 0 0 0 0 0 0 0 0 0 0 0 

lymph node hyperplasia 9 8 5 0 1 0 1 1 5 ,'3 2 0 0 0 11 5 2 0 0 0 0 1 13 5 4 1 0 0 0 {, 

Liver 

hepatocellular 

hemangioma 

tumor 12 17 25 13 2 2 2 2 0 0 1 5 0 1 0 2 0 

altered foci " 2 0 0 0 0 0 1 0 0 1 0 0 0 

liver cell swelling 

20 20 41 25 3 1 2 1 12 6 10 10 0 0 0 29 31 43 39 3 3 0 2 37 39 41 42 2 1 1 v 

vacuo! ization 8 19 

fatty change '1 4 2 1 2 1 )7 18 18 9 1 0 0 

mixed/vacuo1i.+fatty change 

0 3 9 4 0 0 1 0 0 0 0 0 0 0 0 

necrosis 

8 9 31 zo 0 0 0 0 17 18 20 28 0 1 0 

cyst 

14 19 27 15 0 0 1 o· 12 6 10 8 1 0 0 3 5 7 3 0 0 2 2 0 0 0 0 0 0 0 

Kidney 

ol ~I adenocarcinoma 

eel 1 infi 1 tration 

0 0 0 0 0 0 0 1 0 0 0 0 0 23 17 11 16 0 ol 2 20 26 6 6 1 0 0 I Spleen/Lymph node 

1 eu kem i a/lymphoma 

lymph node hyperplasia 

2 

0 

1 2 0 0 0 0 1 0 1 2 0 1 0 1 2 2 0 0 1 2 0 1 2 1 1 0 0 0 ~ 

Pancreas 

lymph node hyperplasia 0 3 0 0 0 2 l 0 0 1 0 0 0 0 0 

Intestine 

lymph node hyperplasia 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 

Testis 

carci fication 1 2 0 0 1 0 0 2 - - - - - - -

Ovary 

granulosa ce 11 tumor - - - - - - - - 0 0 0 1 0 0 0 

Uterus 

r;ys t. i c change - ., - - - - - 31 27 21 22 0 0 0 

Skiri 

ndonocarcinoma 

mal i p;nant. l.ym piloma 

0 l 0 0 0 0 l 0 0 0 0 0 0 0 0 

ndcn11mn 

0 0 I 0 I) 0 0 ?. 0 l ~ 0 0 0 0 

fibroma 

I) 0 l 0 0 0 0 l 0 l l 0 0 0 0 

SqiHUIIOIIH 

() 0 () () 0 0 0 0 0 l 0 0 0 0 0 

co II ilyporplnsia 0 0 ~ 0 () 0 () 0 0 () 0 l 0 0 0 

No. of off'ocLiv<! ( llimor) IIIOIISO ~~ Ill 'l/ l :! :~ .1 :1 :1 ?, R G 8 l 0 l 

C ()ppm I. IOOppm M I OOOpp1n II lOOOOppm 

H 

1 

0 

0 

0 

0 

0 

0 

1 

1 

0 

0 

0 

0 

0 

0 

0 

0 

0 

0 

-

' 

0 

0 

0 

0 

0 

0 

0 

0 
Table L Summary of gross findings in mice fed HBCD for 18 months 

Sex Male Female 

Organs ki I led or died ki !led died killed died 

Findings group c L M H c L M H c L M H c L M H 

No. of animals examined 45 47 45 45 5 3 5 5 48 49 49 49 2 1 1 1 

' 

~ung 

nodule 6 7 3 1 0 1 0 1 1 1 2 1 0 0 0 0 

Jiver 

small 

nodule 

ponctate 

12 21 30 24 2 2 2 2 2 1 5 6 0 1 0 0 on surface 5 7 12 5 0 0 0 0 2 0 0 0 0 0 0 0 

:idney 

change 

nodule 

of 

0 0 0 0 0 0 0 0 0 1 0 0 0 0 0 0 carer 0 4 0 0 0 0 0 0 0 0 0 0 0 0 0 0 

pleen 

swelling 0 2 0 0 0 0 0 1 1 2 2 1 1 0 1 0 

ancreas 

nodule 0 3 0 0 0 2 1 0 0 1 0 0 0 0 0 0 

esenteric lymph 

swelling 0 1 1 0 0 2 1 0 0 3 0 0 0 0 0 0 

as tis 

atrophy 0 1 0 0 0 0 0 0 - - - - - - - -

1ar·y 

cyst - - - - - - - - 1 0 4 4 0 0 0 0 

~erus 

swe 11 ing - - - - - - - - 31 27 24 3 0 0 0 0 

un 

nodu 1 e 0 0 0 0 0 0 l 1 0 0 0 0 0 0 0 0 i nflama t ion 0 3 ?. l 0 0 0 0 0 0 0 1 0 0 0 0 

C Oppm L lOOppm M lOOOppm H lOOOOppm 
-, 

·' ' 

i'ig.2 Body weight of milJe mice fed HBCD for 18 month!; ' 

g 

50 

40 

30 

20 

ri 

g 

50 

40 

30 

20 

0 

t' 

-----<0-- 0 ppm 

100 ppm 

-<l- 1000 ppm 

---o--- 10000 ppm 

20 40 60 80 

weeks 

Fig.3 Body weight of female mice fed HBCD for 18 months· 

--0--- o ppm 

100 ppm 

--a- 1000 ppm 

----<>--- 10000 ppm 

20 40 60 00 

wooks 
-

·'·· 

g 

7 

6 

5 

4 

3 

fig.4 

0 

Foodconsumption: of male mice fed HBCD for 18 months 

-0-- 0 ppm 

100 ppm 

__,___ 1000 ppm 

---<>--- 10000 ppm '. 

20 40 60 80 

weeks 

l"ig.S Foodconsumption of female mice ted HUCD for 18 months 

g 

4.0 

3.8 

3.6 

3.4 

3.2 

3.0 

2.8 

2.6 

0 20 40 00 

wooks 

00 

-0-- oppm 

100 ppm 

-a-- 1000 ppm 

--<>--- 10000 ppm