**September 26**

**— December 13, 2013**  **Peer Review Meeting of Methylene Chloride (CASRN 75**

**- 09** 

**- 2)** 

**- DCM**  **and N**

**- Methylpyrrolidone (CASRN 872** 

**- 50** 

**- 4)** 

**- NMP** 



## BIOSKETCHES FOR DCM

**- NMP PEER REVIEW PANELISTS** 

**Dr. Gary Ginsberg (Chair)** is a toxicologist at the Connecticut Department of Public Health within the Division of Environmental and Occupational Health Assessment. He has responsibility

for human health risk assessments conducted within the state government. Dr. Ginsberg serves as adjunct facult y at the Yale School of Public Health and is an Assistant Clinical Professor at the University of Connecticut School of Community Medicine. He is currentl y a member of the National Academ y of Sciences committee reviewing inorganic arsenic

an d served on two previous NAS committees (Human Biomonitoring, 2007; USEPA Risk Methods which produced Science and Decisions, 2009). He was first author of a manuscript that won best paper of the ye ar award from the Society of Toxicology

Risk Assessment Spe cialty Section, 2009. Dr. Ginsberg was a member of USEPA's Children's Health Protection Advisory Committee until 2009 and is currentl y a member of USEPA's Science Advisory Board. He has participated on expert review panels for state governments in Minnesot a, New Jersey , California and Massachusetts. He was an Oak Ridge Institute for Science and Education (ORI SE) fellow with USEPA's National Center for Environmental Assessment from 2010 to 2012. He has published in the areas of earl y life stage vulnerability , pharmacokinetic modeling, genetic poly morphisms, metabolism in aging populations, fish consumption advisories and environmental risk assessment. Dr. Ginsberg's toxicology experience has involved a variet y of settings: basic research, teaching, working wi thin the pesticide and consulting industries, and now working in public health. Dr. Ginsberg is also co

- author of a book on toxics for the lay public, "What's Toxic, What's Not:" Berkley Books, December 2006.

**Dr. Thomas W. Armstrong** is the Principal Invest igator since 2008 at his sole proprietor consulting compan y, TW A8HR Occupational Hy giene Consulting, LL C. Dr. Armstrong received his B.A. in Chemistry , M.S. in Environmental Health, and Ph.D. in Environmental Engineering, all from Drexel University in Phil adelphia, Pennsy lvania. He currentl y has an Adjunct Professor appointment at the Drexel University School of Public Health. Before he retired from ExxonMobil Biomedical Sciences in 2008, his last position there was as Senior Scientific Associate in Exposur e Sciences. While at ExxonMobil, he developed exposure assessment strategies for and provided support to multiple epidemiology studies, including work under contract to the University of Colorado to support multiple general population epidemiology

investig ations in Shanghai, China. Also, while at ExxonMobil, Dr. Armstrong served on the compan y's internal occupational exposure limit committee and published a method for adjusting exposure limits to extended work schedules. His ongoing research activities incl ude exposure assessment for epidemiology studies, mathematical methods to estimate exposures to chemicals and quantitative risk assessments for Legionella and Legionnaires' disease. He has 30 peer reviewed publications, has contributed multiple chapters to three books and has provided peer reviews to eight journals. Dr. Armstrong has presented on diverse topics at sy mposia in the United States and abroad. He was the lead instructor for American Industrial Hy giene Association (AIHA) professional development courses on mathematical modeling to assesschemical exposures, and Monte Carlo Simulation techniques in exposure assessment, and has

taught in other courses, including a review of toxicology for industrial hy gi enists. He remains active in AIHA risk assessm ent, epidemiology and exposure assessment committee activities. Dr. Armstrong was a member of two National Academy of Sciences committees that conducted reviews of and completed reports on risk assessments for two national biocontainment laboratories. In a ddition, he provided support to a National Institute for Occupational Safet y and Health (NIOSH) review of the institute's occupational exposure assessment strategy , and served on a NIOSH National Occupational Research Agenda committee. He also participated in several panels on EPA children's health issues.

**Dr. Frank A. Barile** is Professor of Applied and Clinical Toxicology in the Department of Pharmaceutical Sciences, St. John's University College of Pharmacy

and Health Sciences, New York. He received his Ph.D. in Toxicology (1982) at St. John's University . He completed post

doctoral fellowships at the Albert Einstein College of Medicine, Bronx, NY, and Columbia University , NY. In 1984, he was appointed Assistant Professor in the Department of Health Scienc es at City

University

of NY. Sixteen y ears later he rejoined St. John's University in the Department of Pharmaceutical Sciences. Dr. Barile holds memberships in the U.S. Society of Toxicology , the American Association for the Advancement of Science, and th e New York Academ y of Sciences. He was elected President of the In Vitro & Alternative Methods Specialt y Section of the U.S. Society of Toxicology

(2005

- 2008) and was recently elected VP

- elect for the Dermal Toxicology

Specialty Section (2013

- 2014), follow ed b y President. He is the recipient of the U.S. Public Health Service Medallion from the Director of the NIEHS, Dr. L inda Birnbaum (June, 2009). Dr. Barile is the recipient of PHS research grants from the National Institutes of Health (NIGMS) for the last 20 y ears, as well as from the Alternative Research & Development Foundation (Jenkinton, PA) and the International Foundation for Ethical Research (Chicago, IL). Dr. Barile has authored approximately 75 papers and abstracts in peer

- reviewed biomedical and toxicology

journals, as well as five books and three chapters, including Clinical Toxicology : Principles and Mechanisms, 2nd edition, 2010 (Informa HealthCare, UK) and Principles of Toxicology

Testing, 2nd edition, 2013 (CRC Press, FL). Recently published articles describe the development of in vitro ocular toxicity testing methods for detecting irritant and corrosive properties of chemicals (

J. Pharmacological Toxicological Methods, 2010) and highlight epigenetic mechanisms using trace metals in embryonic stem cells ( Toxicology Letters, 2012). Dr. Barile serves on the editorial boards of Toxicology In Vitro (2007

- present) and J. Pharmacological & Toxicological Methods (2008

- present). He is currentl y Editor

- in

- Chief of Toxicology In Vitro (2012

- present). He continues fundamental research on the cy totoxic effects of environmental chemicals on cultured human and mammalian embry onic stem cells.

**Dr. Anneclaire J. De Roos** is Associate Professor of Environmental and Occupational Health in the Drexel University

Scho ol of Public Health in Philadelphia, Pennsylvania. She earned a bachelor of arts degree (geograph y/ ecos ys tems) from the University of California at Los Angeles, a master of public health (MPH) degree (epidemiology /biostatistics) from the University

of Cali fornia at Berkeley , and a PhD (epidemiology) in the ye ar 2000 from the University

of North Carolina at Chapel Hill. Her research interests and experience are primaril y in the study

of occupational and environmental exposures to chemicals and radiation as r isk factors for cancer, autoimmune diseases, and intermediate biologic effects. Dr. De Roos' dissertation research focused on parental occupational exposures as risk factors for childhoodcancer in their offspring. From 2000

- 2002, Dr. De Roos trained as a postdoctoral fellow in the

Division of Cancer Epidemiology and Genetics of the National Cancer Institute, where she gained experience in studies of genetic determinants of disease and intermediate biologic effects (immune function, inflammation) of environmental exposures. She was a member of the facult y at the Universit y of Washington (UW) and Fred Hutchinson Cancer Research Center in Seattle, WA from 2003

- 2012, where her research focused on environmental risk factors for non

- Hodgkin ly mphoma, leukemias, and other cancers, including workplace exposures (pesticides, solvents), persistent organic pollutants (PCBs, dioxins), and point sources of pollution (industrial facilities, traffic). Dr. De Roos has been a member of the International Lymphoma Epidemiology (InterLymph) Consortium since 2005, and is currently funded by

the National Institute of Environmental Health Sciences (NIEHS) to conduct a consortium

- based evaluation of occupational solvent exposure as a potential cause of multiple my eloma. At the UW, D r. De Roos taught courses in cancer epidemiology , environmental and occupational epidemiology

, public health in the media, and advanced epidemiologic methods. In her current position at Drexel, Dr. De Roos is developing a new masters' level course in envir onmental risk assessment. She serves as a frequent reviewer for occupational and environmental health journals, most notably as an editorial review board member for Environmental Health Perspectives. She has published over 90 refereed research articles, authored 7 book chapters, and made numerous invited presentations at national and international conferences. Dr. De Roos has also served on several expert committees in recent ye ars, including those reviewing formaldeh yde for NIEHS's Report on Carcinogens an d the trichloroeth yl ene (TCE) health assessment document for the Environmental Protection Agency

.

**Dr. Ronald D. Hood** is Principal of Ronald D. Hood and Associates, Toxicology Consultants. He also is Professor Emeritus of Biological Sciences, having retired from the facult y of the Cell, Molecular, and Developmental Biology Section of the Department of Biological Sciences of the University

of Alabama after 32 y ears of service, and he has been an Adjunct Professor of Public Health, School of Public Health, Uni versit y of Alabama at Birmingham. Dr. Hood received his Ph.D. from Purdue University in 1969 in Reproductive Phy siology and joined the faculty

of the University

of Alabama as an Assistant Professor. He was promoted to the rank of Professor by 1978, and he also served as Interim Department Chair from July 1996 to August, 1997. In addition, Dr. Hood was Consultant in Environmental Medicine for the U.S. Veterans Administration, Office of Medicine and Surgery , Agent Orange Special Projects Office (off site), during 1983, and a Special Consultant, Science Advisory Board, EPA, from 1983 through 1993. He has served as a consultant to pharmaceutical, chemical, and biotech companies, trade associations, federal and state regulatory agencies, and law firms since 1978. Dr. Hood presented toxicology

training courses to regulatory personnel of Health Canada annually from 2006 to 2011. Dr. Hood has served as a member of the editorial boards of Fundamental and Applied Toxicology and Toxicological Sciences , and he was an ad hoc member of EPA's Food Quality Protection Act Science Review Board. Dr. Hood has participated in workshops and expert panels to provide expertise on developmental toxicity and risk assessment, and he was inducted as a Fellow of the Academy

of Toxicologic al Sciences. Dr. Hood has authored, coauthored or edited more than 100 publications (research articles, book chapters and books) in the areas of developmental and reproductive toxicology . Dr. Hood's most recent edited book is Developmental and Reproductive Toxicology, a Practical Approach, Third Edition , published in 2012, by the Informa Healthcare division of CRC Press. Dr. Hood has been active in theTeratology Societ y, chairing the Membership, Education, Constitution/Bylaws, and Website committees. He al so has been active in the Reproductive and Developmental Toxicology Specialty Section of the Society

of Toxicology , and he has served as their newsletter editor.

**Dr. Dale Hattis** is a Research Professor at the George Perkins Marsh Institute at Clark Univers ity

in Worcester, Massachusetts, with a B.A. in Biochemistry from the University

of California, Berkeley

(1967), and a Ph.D. in Genetics from Stanford University (1974). For the past 39 y ears Dr. Hattis has been engaged in the development and application o f methodology to assess the health, ecological and economic impacts of regulatory actions. His work has focused on the development of methodology to incorporate interindividual variability data and quantitative mechanistic information into risk assessments for both cancer and noncancer endpoints, and he has published more than 200 technical papers, including on phy siologicall y based pharmacokinetic modeling. Specific studies have included pharmacokinetic modeling and risks from developmental effects of the organophosphate insecticide chlorpy rifos, dosimetric uncertainties in epidemiological information on dioxin cancer risks, age

- related differences in pharmacokinetic processes and susceptibility for carcinogenesis, renal effects of cadmium, reproductive eff

ects of ethoxyethanol, neurological and cardiovascular effects of methyl
mercury , neurological effects of acry lamide, chronic lung function impairment from coal dust, four pharmacokinetic

- based risk assessments for carcinogens (for perchloroethy lene, ethyl ene oxide, butadiene and diesel particulates), an analy sis of uncertainties in pharmacokinetic modeling for perchloroethylene, and an anal ys is of differences among species in processes related to carcinogenesis. He currentl y is a member of the National Tox icology Program Board of Scientific Counselors. In the past, he has served as a member of the Environmental Health Committee of the Environmental Protection Agency 's Science Advisory Board, and as a member of the Food Quality

Protection Act Science Review Board. He has been a councilor and is a Fellow of the Societ y for Risk Analy sis.

**Dr. John C. Kissel** is currentl y Professor of Environmental and Occupational Health Sciences at the University

of Washington in Seattle, where he has been a member of the facul ty since 1990. He held a prior position in the School of Public and Environmental Affairs at Indiana University

. Dr. Kissel holds a Ph.D. in Civil/Environmental Engineering from Stanford University and is a registered professional engineer. Dr. Kissel's re search interests generally involve human exposure assessment, with emphasis on exposures related to waste management, agricultural and residential use of pesticides, and consumer products. He is particularl y interested in probabilistic prediction of aggreg ate exposure and reconciliation of model predictions with observed biomarker data. Dr. Kissel and his students have produced multiple papers describing human exposure to soil that are listed as "key studies" in US EPA's Exposure Factors Handbook . Dr. Kisse l is a former President and Councilor of the International Societ y of Exposure Science and also served one term as chair of the Exposure Assessment Specialty Group within the Society for Risk Analy sis. He was a member of a National Academ y of Sciences Comm ittee that evaluated Superfund

- related remediation of mining and smelting related contamination in the Coeur d'Alene Basin in Idaho and a reviewer of the WHO environmental health criteria document on Dermal Exposure, which will be published soon. Dr. Kisse l has served as an ad hoc member of US EPA's FIFRA Science Advisory Panel on multiple occasions and is currently a member of EPA's Human Studies Review Board. His recent research activities have been funded b y US EPA, US DOE, NIOSH and the Washington State Departments of Ecology and Health.**Dr. Stephen B. Pruett** is Professor of Immunotoxicology and Head of the Department of Basic Sciences at the College of Veterinary Medicine, Mississippi State University . He earned his B.S. degree from Northwestern State University of Louisiana (Microbiology) and his Ph.D. degree from L ouisiana State University School of Medicine in Shreveport (Immunology). He had post

doctoral training at the University of Alabama of Birmingham School of Medicine (Immunology) with Dr. J. Claude Bennett, and received training in toxicology and pharmacology during a Sabbatical with Dr. Albert E. Munson at the Medical College of Virginia. Dr. Pruett began his academic research career as an assistant professor in the Department of Biological S ciences at Mississippi State Universit y and left at the rank of professor after 13 years to take a similar position at the L SU Health Sciences Center in Shreveport. He returned to Mississippi State University

in his current position after 10 y ears at L SU. His research interests include the effects of drugs, chemicals, and stress on the immune sy stem. He has a long interest in pesticides, drugs of abuse, and ps ychological stressors and has been funded by the National Institutes of Health (NIH) for work in ea ch of these areas. He is currentl y a member of the Innate Immunity and Inflammation Study

Section for NIH and has served as a frequent ad hoc grant reviewer for several other NIH stud y sections beginning in 1990. He serves on the editorial boards of two le ading toxicology journals, Toxicological Sciences and Toxicology and Applied Pharmacology , and recently served several ye ars as an Associate Editor for the Journal of Immunology . He has served in several leadership positions in the Society of Toxicology

, i ncluding President of the South Central Chapter and President of the Immunotoxicology Specialty Section. He is a Fellow of the Academ y of Toxicological Sciences and a member of the American College of Toxicologists. He has published more than 115 peer

- revi ewed manuscripts and 10 book chapters, and has been an invited speaker at numerous meetings in the U.S., Australia, Europe, and Japan.