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### C:Jt:Y£;1?;:) 125(1985) J. K. Haseman et a!. : JNCL Vol. 75 November(1985)

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# I 1 Table 2. Summary of histopatholor.ical finrlinr.s in mice fed IIBCD for 18 months Sex Male Female Organs killed or died killed died k

### i !led died · Findings group 

## c L M H 

## c L M ll 

## c L M H 

## c L M No. of animals examined 

### 45 47 

### 45 dr ..J 

### 5 3 

### 5 5 48 49 49 49 2 1 

### 1 Lung f adenocarcinoma 

### 0 1 0 0 0 0 0 0 0 0 0 0 0 0 

### 0 adenoma 

### 5 9 8 

### 5 0 1 

### 0 

### 1 1 

### 5 ,'3 2 0 0 0 lymph node hyperplasia 11 

### 5 2 0 0 0 0 1 13 

### 5 4 1 0 0 0 {, Liver hepatocellular tumor 12 17 25 13 2 2 2 2 0 0 1 

### 5 0 1 0 hemangioma 

### 2 0 2 0 0 0 0 0 1 0 0 1 0 0 0 

### " altered foci 20 20 41 

### 25 3 1 2 1 12 6 10 10 0 0 0 liver cell swelling 29 31 

### 43 39 3 3 0 2 

### 37 39 41 42 2 1 1 v vacuo! ization 8 19 '1 4 2 1 2 1 )7 18 18 9 1 0 0 fatty change 0 3 9 4 0 0 1 0 0 0 0 0 0 0 0 mixed/vacuo1i.+fatty change 8 9 31 

## zo 0 0 0 0 17 18 20 28 0 1 0 necrosis 14 19 27 15 0 0 1 

## o· 12 6 10 8 1 0 0 cyst 3 

### 5 7 3 0 0 2 2 0 0 0 0 0 0 0 Kidney 

## ol



# ~I adenocarcinoma 0 0 0 0 0 0 0 1 0 0 0 0 0 eel 1 infi 1 tration 23 17 

### 11 16 0 

## ol 2 20 26 6 6 1 0 0 

# I Spleen/Lymph node 1

eu kemia/lymphoma 2 1 2 0 0 0 0 1 0 1 2 0 1 0 1 lymph node hyperplasia 0 2 2 0 0 1 2 0 1 2 1 1 0 0 0 **~** Pancreas lymph node hyperplasia 0 3 0 0 0 2 l 0 0 1 0 0 0 0 0 Intestine lymph node hyperplasia 0 0 0 0 0 0 0 0 0 3 0 0 0 0 0 Testis carci fication 1 2 0 0 1 0 0 2 - 

### - - - - - - Ovary granulosa ce 11 tumor 

## - - - - 

### - - - - 0 0 0 1 0 0 0 Uterus r;ys t. i c change - ., - - - - 

### - 31 27 21 22 0 0 0 Skiri ndonocarcinoma 0 l 0 0 0 0 l 0 0 0 0 0 0 0 0 mal ip;nant. l.ym piloma 0 0 I 0 I) 0 0 ?. 0 l

**~** 0 0 0 0 

### ndcn11mn I) 0 l 0 0 0 0 l 0 l l 0 0 0 0 fibroma () 0 () () 0 0 0 0 0 l 0 0 0 0 0 SqiHUIIOIIH co II ilyporplnsia 0 0

**~** 0 () 0 () 0 0 () 0 l 0 0 0 No. of off'ocLiv<! ( llimor) IIIOIISO
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- ' 0

0 0 0 0 0 0 0Table L Summary of gross findings in mice fed HBCD for 18 months Sex Male Female Organs ki I led or died ki !led died killed died Findings group 

# c L M H 

## c L M H 

## c L M H 

## c L M H No. of animals examined 

### 45 47 

### 45 45 

### 5 3 

### 5 5 48 49 49 49 2 

### 1 1 1 '
**~ung** nodule 

### 6 7 

### 3 

### 1 0 1 

### 0 1 

### 1 1 2 

### 1 0 

### 0 0 0 Jiver nodule 12 21 

### 30 24 2 2 2 2 2 

### 1 5 6 0 

### 1 0 0 small ponctate on surface 

### 5 7 12 

### 5 0 0 0 0 2 

### 0 0 0 0 0 0 0 :idney nodule 

### 0 0 0 0 0 0 0 0 0 

### 1 0 0 0 0 0 0 change of carer 

### 0 4 

### 0 0 0 0 0 0 0 0 0 0 0 0 0 0 pleen swelling 

### 0 2 

### 0 0 

### 0 0 0 1 1 2 2 

### 1 1 0 1 

### 0 ancreas nodule 

### 0 3 

### 0 0 0 2 

### 1 0 0 

### 1 0 0 0 

### 0 0 0 esenteric lymph swelling 

### 0 1 1 0 

### 0 2 1 

### 0 0 3 

### 0 0 

### 0 0 0 0 as tis

atrophy 

### 0 1 0 

### 0 0 0 0 

### 0 

## - - - - - - - - 1ar·y

cyst - 

### - - - - - - - 

### 1 0 4 4 

### 0 0 0 0

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swe 

### 11 ing - - - - - - - 

## - 31 27 24 3 

### 0 0 0 0 un

nodu 

### 1 e 

### 0 

### 0 0 

### 0 0 0 l 1 

### 0 0 0 0 0 0 0 0 inflama t ion 

### 0 3 ?. l 

### 0 0 0 

### 0 0 0 0 1 

### 0 0 0 0 C Oppm L lOOppm M lOOOppm H lOOOOppm

### -,

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### ' i'ig.2 Body weight of milJe mice fed HBCD for 18 month!; ' g 50 40 30 20 

### ri

g 50 40 30 20 0 t' -----<0-- 0 ppm 100 ppm -<l- 1000 ppm ---o--- 10000 ppm 20 40 60 80 weeks Fig.3 Body weight of female mice fed HBCD for 18 months·
--0--- o ppm 100 ppm --a- 1000 ppm ----<>--- 10000 ppm 20 40 60 00 wooks

# -

·'·· g 7 6 5 4 3fig.4

0 Foodconsumption: of male mice fed HBCD for 18 months -0-- 0 ppm 100 ppm 

### __,___ 1000 ppm ---<>--- 10000 ppm 

## '. 20 40 60 80 weeks l"ig.S Foodconsumption of female mice ted HUCD for 18 months g 4.0 3.8 3.6 3.4 3.2 3.0 2.8 

### 2.6 0 20 40 00 wooks 00 -0-- oppm 100 ppm -a-- 1000 ppm --<>--- 10000 ppm