# EPA Registration Number 66330-333 Vol. 3

# , 

# - 1111111111111111111111111111PleaseReturnJackettoFileRoomforDataExtractionOPPINDataEntryto:edwards.joyceSentby:DCOPPAPPS01Cc:montague.kathryn,SUBJECT:PleaseReturnJackettoFileRoomforDataExtractionforRegistration:Decision:393160AnactionwasjustcompletedforRegistration(66330-333),Decision(393160)thatmayrequiredataextractionandIorimagingofalabelforinclusioninthePesticideProductLabelSystem.Pleasereturnjacket(9275851)tothefileroom,andcheckitouttoISB"sdatamanagementcontractorassoonaspossible.Thisisanautomaticallygeneratednotificationmessage.Pleasedonotreplytothisaddress.07/29/201012:33PM

# Material to be added to an e-Jacket/Jacket

Description: 

# r-ece:;i'**~b** 

# ecD ail

1.

# ;;;7~lacement within the e-Jacket/jacket:
wDefault: (chronological, top 

# = newest)

o 

# File Location: (PDF page number, i.e., "before page 

# 45")

2. GYSend to Data Extraction contractors this material:

# ~ Newly stamped accepted label

# ~' Notification

o NewCSF

o Other:

3. Attach this coversheet to the top of the material or jacket. It must be well organized and clipped together, NOT STAPLED. Then give the material with this coversheet to staff in the Information Services Center (Room S-4900).



# Reviewer's N 

# a me;..:**"""';':fI,~~1A** o!!>,o!..Jo.-4M.

# Xl.I~~-


# Phone: 

# ]0334103&1 Division: 

# R.O/HB

Date: 

# -----1-1 '7 / 

# -'-O-'-1/!-""o""-A-'--

______ _ 

# 1/

Created August 

### 19, 2008

# / 

# !

U.S. ENVIRONMENTAL PROTECTION 

## - EPA Reg. Number: Date of Issuance:

",,"'<teO**~1T"r.** 

### AGENCY

v '. 

### 66330-333 

# f**~ ~**  

### Office of Pesticide Programs**,~.** 

### Registration Division (7505P) 

# .. , 

# "..,**~** 'l '--" 

# .

-- 

### Ariel Rios Building ,_, _ 'J "( "ROlf.' 

### 1200 Pennsylvania Ave., NW Washington, D.C. 20460
NOTICE OF PESTICIDE: Term of Issuance:



### _ Registration 

## -.X. Reregistration Name of Pesticide Product: 

### (under FIFRA, as amended) Thidiazuron-Diuron EC
Name and Address of Registrant (include ZIP Code): Arysta LifeScience North America, LLC 15401 Weston Parkway, Suite 150 Cary, NC 27513
Note: Changes in labeling differing in substance from that accepted in connection with this registration must be submitted to and accepted by the Registration Division prior to use of the label in commerce. In any correspondence on this product always refer to the above EPA registration number.

On the basis of infonnation furnished by the registrant, the above named pesticide is hereby registered/reregistered under the Federal Insecticide, Fungicide and Rodenticide Act. Registration is in no way to be construed as an endorsement or recommendation of this product by the Agency. In 

### order to protect health and the environment, the Administrator, on his motion, may at any time suspend or cancel the registration of a pesticide in accordance with the Act. The acceptance of any

name in connection with the registration of a product under this Act is not to be construed as giving the registrant a right to exclusive use of the name or to its use if it has been covered by others.

This product is reregistered in accordance with FIFRA provided that you:

I) 

### Submit and/or cite all data required for registration/reregistration review of your product when the Agency requires all registrants of similar products to submit data.

Signature of Approving Official: Date: 

# /5/

0[-("> 

# , i: ;< ',-, 

# c,
Joanne Miller Senior Registration Specialist Herbicide Branch, Team 23 Registration Division (7505P)

# !

Page 2 EPA Reg. 66330-333

2. Delete "Thidiazuron products

... exposures due to drift would be reduced" from the Agricultural Use Requirements box on page 5. Place the following language in the Spray Drift section, "Thidiazuron products can not be applied by air within 

### 'li mile of lettuce or within 5 miles upwind of citrus in flush (burst of new growth, as in springtime) in the Rio Grande Valley of Texas. Ground applications are restricted to no less than 100 feet away from lettuce and no less than 

### 'li mile upwind from citrus. (In general, a decrease in droplet size

... would be reduced)."

3. On page 6, add "except as noted for lettuce and citrus" after "Do not apply by air if sensitive non-target crops are within 100 feed of the application site."

4. Change the PPE section to: "Some materials that are chemical-resistant to this product are made of barrier laminate or butyl rubber. If you want more options, follow the instructions for category B on an EPA chemicalresistance category selection chart. Pilots and flaggers must wear: Long-sleeved shirt and long pants, shoes, and socks. Mixers, loaders, applicators, and other handlers must wear: Coveralls over short-sleeved shirt and short pants, chemical-resistant shoes plus socks, goggles or faceshield, chemical-resistant gloves, chemical-resistant headgear for overhead exposure, chemical-resistant apron when mixing, loading, or cleaning equipment or spills, and NIOSH approved particulate filtering respirator equipped with N, R, 

### or P class filter media. The respirator should have a NIOSH approval number prefix TC-84A. It 

### is recommended that you require that the respirator wearer be fit tested, and trained in the use, maintenance, and limitations of the respirator. See engineering controls for additional requirements."

5. Additional text in bold must be added "Maximum application rate ofO.3Ibs. ai thidiazuron
per acre per year. Maximum of2 applications, but not to exceed 0.3 lbs. ai thidiazuron per acre per year." Also add "Maximum Thidiazuron application rate is 0.125 lbs. ai/A (under normal conditions) or 0.2Ibs. ai/A (under variable conditions)."

6. On page 3, delete "General" from "General Infonnation".

7. On page 6, change "the spray boom should" to "the spray boom must".

8. On page 6 and throughout the label, change "recommended" to "directed" and "recommendations" to "directions".

9. On page 8, add "to the extent consistent with applicable law" in front of "Arysta LifeScience North America, LLC assumes no liability" and "all such risks shall be assumed".

10. On page 7, clarifY 

### the heading "active ingredients per acre" and revise the amounts, the numbers in ais per acre correspond only to the amounts of diuron.

### I

Page 3 EPA Reg. 66330-333

A stamped copy of the label is enclosed for your records. You must submit one copy of the final 

### printed label before you release the product for shipment. Products shipped after 12 months from the date of this letter or the next printing of the label whichever oeems first, must bear the new revised label. 

### If these conditions are not complied with, the registration will 

### be subject to cancellation in accordance with FIFRA. Yom release for shipment of the product constitutes acceptance of these conditions. This label supersedes all other previously accepted labels. If you have any questions please call Erik Kraft at**703~308~9358** 

### or email atKraft.Erik@epa.gov.

# THIDIAZURON-DIURON EC

COTTON DEFOLIANT

For Agricultural Use Only 

### RED 

### + PR Notice**2007~4**



## ACCEPTED with COMMENTS In EPA Lettel' Dated:

ACTIVE INGREDIENTS: Thidiazuron:**N~phenyl~N'~1 ,2,3~thidiazol-5~ylurea** * 1 " c! Inseclicidc.

. ... ............ giddc, and Rodenticide Act 

### Diuron:**3~(3,4~dichlorophenyl)~** 

### 1,**1~dimethylurea*** 

### ....
......... ...... ... ............. amended, forthe pesticide 

### OTHER INGREDIENTS:....

. ................ . ................................**~tcred** under EPA Reg. No. 

### TOTAL 100%

Contains 1 lb. Thidiazuron per gallon and 0.5 lb. Diuron per gallon 

# Gio330-S33

KEEP OUT OF REACH OF CHILDREN 

## DANGER

- PELIGRO
Si usted no entiende la etiqueta, busque a alguien para que se la explique a usted en detalle. (If you do not understand this label, find someone to explain it to you in detail.)

IF IN EYES:

IF ON SKIN OR CLOTHING:

IF INHALED:

IF SWALLOWED: 

## •
•

• 

# • •
•
• 

# •

•
• 

# • FIRST AID Hold eye open and rinse slowly and gently with water for**15~20** 

### minutes. Remove contact lenses, if present, after the first 5 minutes, then continue rinsing. Call a poison control center or doctor for treatment advice. Take off contaminated clothing. Rinse skin immediately with plenty of water for**15~20** 

### minutes. Call a Doison control center or doctor for treatment advice. Move person to fresh air. If person is not breathing, call 911 or an ambulance, then give artificial respiration, preferably**mouth~to~mouth** 

### is possible. Call a poison control center or doctor for treatment advice. Immediately call a poison control center or doctor for treatment advice. Do not induce vomiting unless told to do so by a poison control center or doctor.

• Have person sip a glass or water if able to swallow.

, , • Do not (live anvthinq by mouth to an unconscious persor<.' , " , : ' •••• NOTE TO PHYSICIAN: If in eyes, refer to an ophthalmologist for

# follow~up carer-;-·:'--:'--;-.--1 Probable mucosal damage may contraindicate the use of gastric lavage.

, ,**;...:...:..~.** 

### __**-'-'~::...'** 

# --I

HOT LINE NUMBER ' , 

### " EMERGENCY TELEPHONE NUMBERS:

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### " , 

### , 

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, 

## "

"



### , Have the product container or label with you when calling a poison control center or doctbr 

# C'r going for treatment. "'" "" FOR 24·HOUR EMERGENCY MEDICAL ASSISTANCE CALL: 1.866·303·6962 ' ",,' FOR CHEMICAL EMERGENCY: Spill, leak, fire, exposure, or accident call CHEMTREC**1~800~424~9290** 

### "



### , ,


### SEE INSIDE (SIDE PANEL) FOR ADDITIONAL PRECAUTIONS AND USE DIRECTIONS

EPA Reg. No,**66330~333** 

### AD 081508 EPA Est. No.**51036~GA~001** 

### NET CONTENTS:

___ _

Manufactured for Arysta LifeScience North America, LLC 15401 Weston Parkway, Suite 150 Cary, NC 27513

Filename: Thidiazuron-Diuron EC (333-RED 020507) AD08t508 RED + PR 2007-4 (C!can).doc 

### Page I

### PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS AND DOMESTIC ANIMALS DANGER RED 

### + PR Notice 2007-4

Corrosive. Causes irreversible eye damage. Causes skin irritation. Do not get in eyes, on skin, or on clothing.



### PERSONAL PROTECTIVE EQUIPMENT (PPE)

All mixers, loaders, and applicators must wear:

• Long-sleeved shirt

• Long pants

• Shoes and socks

• Chemical-resistant gloves

• Goggles, face shield, or glasses

• Chemical-resistant apron when mixing, loading or cleaning equipment or spills, and chemicalresistant headgear for overhead exposure See Engineering Controls for Requirements

In addition to the PPE above, all handlers except for ground boom applicators, pilots, and flaggers must also wear a NIOSH approved particulate filtering respirator equipped with N,R, or P class filter media. The respirator should have a NIOSH approval number prefix TC-84A. It is recommended that you require that the respirator wearer be fit tested, and trained in the use, maintenance, and limitations of the respirator.



### USERS SAFETY REQUIREMENTS Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry.



### ENGINEERING CONTROLS STATEMENT Engineering Controls for Aerial Application: Enclosed Cockpits Engineering Controls: Pilots must use an enclosed cockpit that meets the requirements, listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)]. Flaggers supporting aerial applications must use an enclosed cab that meets the definition in the Worker Protection Standard for Agricultural Pesticides [40 CFR 170.240(d)(5)] for dermal protection. In addition, flaggers must wear long-sleeved shirt, long pants, shoes, and socks.



### ,----------"U"SEiCR""S"'AcF"ETYTVDR"E"C"O"M"'M"E"N"'D"A"'T'"IO"N'"S,-----,,-,-,--:

.. •••

Users should:

• Wash hands before eating, drinking, chewing gum, using tobacco, or using tne toilet.

, • Remove cI?thing/PPE immediately if pesticide gets inside. Then wash

### thor6~ghly and put:on clean clothing.

, , ': ••

• Remove PPE immediately after handling this product. Wash the**outsid~'I)·I'** 

### gloves**tJE:!for~** 

### removin

. As soon as ossible, wash thorou hi and chan e into clean clotlJip'
._, '

, , 

# ..

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### ENVIRONMENTAL HAZARDS 

### , , 

### Do not apply directly to water, or to areas where surface water is present or to intertidal areas

### belo~ the

mean high water mark. Do not contaminate water when disposing of equipment wash water or rinsate.

This product may contaminate water through drift of spray in the wind. This product has a high potential for runoff for several months or more after application. Poorly draining soils and soils with shallow water tables are more prone to produce runoff that contains this product. A level, well-maintained vegetative buffer strip between areas to which this product is applied and surface water features such as ponds, streams, and springs will reduce the potential for contamination of water from runoff. Runoff of this product will be reduced by avoiding applications when rainfall is forecasted to occur within 48 hours. Sound erosion control practices will reduce this product's contribution to surface water contamination.

Filename: Thidiazuron-Diuron EC (333-RED 020507) AD08! 508 RED + PR 2007-4 (Clean).doc 

### Page 2RED 

### + PR Notice 2007-4

This chemical has properties and characteristics associated with chemicals detected in ground water. Use of this chemical in areas where soils are permeable, particularly where the water table is shallow, may result in groundwater contamination.

STORAGE AND DISPOSAL Do not contaminate water, food, or feed by storage or disposal.

PESTICIDE STORAGE: Store this product in a cool, dry place in its original container only. Container should be closed when not in use. Do not expose the product to open flame excessive heat. Store in original container and keep closed.

PESTICIDE DISPOSAL: Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of Federal law. If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous Waste representative at the nearest EPA Regional Office for guidance.

CONTAINER DISPOSAL: Nonrefillable container. Do not reuse or refill this container. Triple rinse container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents into application equipment or a mix tank and drain for 

### 10 seconds after the flow begins to drip. Fill the container 

### y,. full with water and recap. Shake for 

### 10 seconds. Pour rinsate into application equipment or
a mix tank or store rinsate for later use or disposal. Drain for 

### 10 seconds after the flow begins to drip. Repeat this procedure two more times. Offer for recycling, if available, or puncture and dispose of in sanitarv landfill, or bv other orocedures aooroved by State and local authorities.

PHYSICAL OR CHEMICAL HAZARDS Do nol use or store near heat or open flame. To Contain a Spill: Absorb liquid by covering it with cat litter, commercial clay, lime, sand, sawdust, or soda ash. Once absorbed, bUry the cleaning materials and cleanse the spill area with a detergent and water solution.

GENERAL INFORMATION THIDIAZURON-DIURON EC is a harvest aid for cotton, used for leaf removal prior to harvest. THIDIAZURON-DIURON EC can be applied in most weather conditions, both warm and cool.

USE PRECAUTIONS This product is not to be applied through any type of irrigation system. Effectiveness of THIDIAZURON-DIURON EC will be reduced if rainfall occurs within 

### 12 hours post application.**~,** ,. :. Foliage from treated plants or gin trash is not to be fed to livestock. ' , , , , , ,

Rotation to the following crops requires the minimum specified periods be\ow. 9fter the : last application ofTHIDIAZURON-DIURON EC: " small grains, sorghum) corn, or root crops (except carrots, onions)

.......................... two (2) 

## ,moAfhs legumes (including alfalfa) or leafy vegetable (except lettuce)

.. '.' 

# i '.hyo (2) mOQths cole crops, garlic, safflower, tomatoes, and watermelon

....................................... ... '.:.'.i. two (2) 1lJ991hs carrots

......................................................................................................... three (3) t1J90ttlS onions

............................................................................................................. four (4) mont.hs cantaloupe, honeydew melon/casaba melon, muskmelon, or peppers

........................... five (5) 

### mOf']th's lettuce

...................... when soil has been deep-plowed 

### (12-15 inches)

....................... two (2) months

OR lettuce

............. when soil is only disced (4-6 inches)

.............................. nine (9) months All other crops...........

............... . ....................................................... twelve 

### (12) months

Special Note for inter-cropped grains and legumes planted either as cover crops or planted into treated fields before the minimum two (2) month plant back time after the final THIDIAZURON-DIURON EC application: Any such crops are prohibited for use as feed or food and may be used only as cover crops.

Do not use immature crops for food or feed.

Filename: Thidiazuron-Diuron EC (333-RED 020507) AD081508 RED + PR 2007-4 (Clean).doc 

### Page 3

### RED 

### + PR Notice**2007~4**


### Prevent spray drift from contacting crops other than mature cotton, since this product may defoliate or injure other plant species.

Mixtures with organophosphates can increase nontarget crop phytotoxicity. Exercise additional care when lettuce, citrus, cantaloupes or any other edible crops are adjacent to**THIDIAZURON~DIURON** 

### EC treated cotlon fields.

PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL ONTO NONTARGET CROPS Under windy weather conditions, applications of**THIDIAZURON~DIURON** 

### EC may drift to non-target crops. The following procedures can help reduce the potential for drift:

• If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground applications**ofTHIDIAZURON~DIURON** 

### EC.

• Nozzle pressure of 20-30 psi is recommended.

• Do not apply this product during a temperature inversion because drift potential is high. In addition, do not apply this product if the development of a temperature inversion appears likely during the application period.

RIO GRANDE VALLEY OF TEXAS PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL The following procedures can help reduce the potential for drift:

• If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground applications of THIDIAZURON-DIURON EC. If wind speeds are less than ten (10) miles per hour, observe local recommendations from your State Extension Cotton Specialist.

• Nozzle pressure of 20-30 psi is recommended.

• Do not apply this product during a temperature inversion because drift potential is high. In addition, do not apply this product if the development of a temperature inversion appears likely during the application period.

• Use the maximum nozzle orifice size that provides proper coverage and deposition of this product.

• CITRUS AREAS: Do not apply this product by ground within 0.5 mile or by air within 5 miles downwind of citrus in flush.

DIRECTIONS FOR USE It is a violation of Federal law to use this product in a manner inconsistent with 

### its labeling.

Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application.

,,,

, ,"

Filename: Thidiazuron-Diuron EC (333·RED 020507) AD08J508 RED + PR 2007-4 (Clean).doc 

### Page 4 , ,


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### RED 

### + PR Notice 2007-4

AGRICULTURAL USE REQUIREMENTS Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR Part 170. This Standard contains requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific instructions and exceptions pertaining to the statement on this label about personal protective equipment (PPE), and**restricted~entry** 

### interval. The requirements in this box only apply to uses of this product that are covered by the Worker Protection Standard.

Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 24 hours. For minimum early entry PPE use the following:

PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as soil or water, is:

• Coveralls

• Chemical-resistant gloves made of any waterproof material

• Shoes plus socks Thidiazuron products can not be applied by air within 

### X. mile of lettuce or 5 mlles downwind of the pOint of application when citrus is in flush (burst of new growth, as in springtime) in the Rio Grande valley of Texas. Ground applications are restricted to 100 feet away from lettuce and 

### X. mile downwind from the point of application for citrus. (In general, a decrease in droplet size or increase in wind speed at the time of application will result in risk to non-target organisms. Alternatively, if droplet size is coarser or wind speeds are lower, exposures due to drift would be reduced).

SPRAY DRIFT Requirements for reducing spray drift for Diuron ground and aerial applications: Use best practices to avoid drift to all other crops and non-target areas. Do not apply when conditions favor drift from target areas. The interaction of many equipment- and weather-related factors determine the potential for spray drift. Avoiding spray drift at the application site is the responsibility of the applicator. The applicator must follow the most restrictive precautions to avoid drift, including those found in this labeling as well as applicable state and local regulations and ordinances. A drift control agent may reduce drift, however, it may also decrease weed control.

Make aerial or ground applications only when the wind speed is less than or equal to 10 miles per hour.

Do not make aerial or ground applications into temperature inversions.

Filename: Thidiazuron-Diuron EC (333-RED 020507) ADOS! 508 RED + PR 2007-4 (Clean).doc 

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# . ,RED 

### + PR Notice 

### 2007·4

Apply with medium or coarser spray (according to ASAE standard 572) for standard nozzles,

Additional requirements for ground applications: When applying to crops, apply with nozzle height no more than 2 feet above the ground or crop canopy. When applying to non·crop areas, use lowest nozzle height consistent with safety and efficacy. Direct spray into target vegetation.

Additional requirements for aerial applications: The spray boom should be mounted on the aircraft so as to minimize drift caused by wing tip vortices. The boom length must not exceed 75% of the wingspan or 90% of rotor blade diameter.

Use upwind swath displacement.

When applying to crops, do not release spray at a height greater than 6 to 10 feet above the ground or crop canopy. When applying to non·crop areas, apply at a minimum safe altitude above the area being treated.

Do not apply by alr if sensitive non·target crops are within 100 feet of the application site.

TIME OF APPLICATION THIDIAZURON·DIURON EC defoliant applications are to be made only on mature cotton plants when the uppermost harvestable boll is mature. Boll maturity is defined as 1) when a boll is squeezed between thumb and finger, it does not dent; 2) when cutting a cross section with a sharp knife is difficult; 3) when seeds in cross section lack liquid within the seed coat or outer edges of seed coat are light brown; and 4) when fully developed cotyledons are present.

Make applications of THIDIAZURON·DIURON EC at least 5 days prior to expected harvest date.

NOTE: Adequate defoliation with THIDIAZURON·DIURON EC depends on three factors:

• Cotton is actively growing.

• High relative humidity.

• Cotton plant leaves are turgid and not desiccated.

A ITENTION: Desiccation and/or leaf freezing may occur during periods of high temperature when adjuvants are added to THIDIAZURON·DIURON EC application solution. Products and adjuvants known to cause desiccation of cotton leaf tissue should not be used.



### , 

# .**,.~~~** 

# . • , , , ) , , > Under low nighttime temperatures (below 60°F) or otherwise adverse conditions, this**pro(JU!~t,** when llsed alone, may provide less than expected defoliation and / or regrowth suppression. '

APPLICATION INFORMATION 

### " ' 

### , 

# .. Use an adequate volume of water with the recommended amount of THIDIAZUR0N·DIURC>N· Et: defoliant to uniformly and completely cover leaves. For ground equipment, apply 10

- 25 g3110n per acre and by air, use 2 -10 gallons per acre. Maintain agitation during application. " . , .

,,,. >

### ~ , ) > ,



### , 

### " " " DOSAGE INFORMATION Application Rate: Before harvest, use .075 Ibs ai/acre (.050 Ibs ai Diazuron/,Q25 Diuron)

- 

### O.1B'1" fbs ai/acre (0.125 lbs ai Diazuronl.062 Ibs ai Diuron) (6.4·16 

### fl. 

### oz.lA of formulation). Maximum application rate of 0.3 Ibs ai/acre per year, Maximum of 2 applications, but not to exceed 0.3 Ibs ai/acre per year.

One gallon of THIDIAZURON-DIURON EC will treat 8 - 20 acres. Refer to the dose rate table below.

In some situations, a follow-up application may be needed. THJDIAZURON-DIURON EC may be used for this application. Other defoliants may be needed. If additional boll opening is required, Ethephon 6 may be used at recommended rates; see product label for rates and timings. Consult your local State Extension Cotton Specialist recommendations for rates and timings.

Filename: Thidiazuron-Diuron EC (333·RED 020507) AD081508 RED + PR 2007-4 (Clean).doc Page 6

### RED + PR Notice 2007-4

The maximum annual use rate ofTHIDIAZURON-DIURON EC is 16 oz. per acre per season. Maximum application rate of 0.3 Ibs ai/acre per year. Maximum of 2 applications, but not to exceed 0.3 Ibs ai/acre per year. Minimum retreatment interval is 21 days.

TANK MIX OF Thidiazuron-Diuron SC plus other cotton defoliant products: The tank mix of Thidiazuron-Diuron SC plus other cotton defoliant products is recommended to improve overall defoliation, and as an aid in accelerating the opening of mature, unopened cotton bolls. Best activity will be obtained where the tank mix is applied to mature cotton plants. Do not apply tank mix before sufficient unopened bolls have matured to produce the desired cotton yield.

For cotton produced in non-arid conditions, apply Thidiazuron-Diuron SC at a rate of 3.2 to 6.4 fluid

ounces per acre plus other cotton defoliant products at a rate of 21 to 42 fluid ounces per acre.

For cotton produced in arid conditions, apply Thjdiazuron-Diuron SC at a rate of 6.4 to 16 fluid ounces per
acre plus other cotton defoliant products at a rate of 21 to 42 fluid ounces per acre.

MIXING INSTRUCTIONS 1. Fill spray applicator tank with at least one half of the water to be used 2. Start agitation 3. Add the appropriate volume of THIDIAZURON -DIURON EC 4. Continue agitation and fill tank with the remainder of the water to be used 5. Agitation should continue throughout the application

CALIFORNIA ONLY: PRECONDITIONING When used as a pre-conditioner seven to ten days before application of this or other defoliant compounds, this product will improve the efficacy of such a defoliant application. Before use, observe all product label directions, recommendations and prohibitions on both product's labels.

Application Rate: Use 4-6 fl. 

## oz. of this productfacre in an aerial application of 2-10 gallons of spray solution or ground application of 10-25 gallons of spray solution

APPLICATION RATE TABLE for THIDIAZURON DIURON EC



# - THIDIAZURON-DIURON EC One Gallon of THIDIAZURON- Active Ingredients per Acre Formulated Product DIU RON EC Will Treat 6.4 oz.lAcre 20 Acres 0.05 Ibs. ai/Acre 

### (004 pUAere) , 

### , " ,> " 8.90z.lAcre 15 Acres**0.07Tbs.·~AYAcre** 

### , , , , (0.56 PuAcre) , , 

### 12.8 oz.lAcre 10 Acres 0.1 O"lbB.' AijAcre "



### , 

### , (0.8 pUAere) , " '"


### ,**~,6.0** 

### oz.lAcre 8 Acres 0.125 

### !t£, .ai/Acre' " ,

, 

### 1.0 QUAere) ,

, 

### , ,**--~,.** " 

# . DO NOT APPLY MORE THAN 1,0 PINT OF THIDIAZURON-DIURON EC PER ACRE PER**SEA~ON.** 

### , ",

, 

### IMPORTANT CLEANOUT INSTRUCTIONS

, ,", When applying THIDIAZURON-DIURON EC, a residue may form in application equipment. This residue

can best be flushed out of the spraying system by using a commercial tank cleaner when done while residue is still fresh and moist. DO NOT ALLOW EQUIPMENT TO DRY BEFORE CLEAN OUT. Consult your State Extension Cotton Specialist for recommended lank cleaners and cleaning procedures.

Use tank cleaner and waler immediately after application. Flush the entire syslem including nozzles, booms, application tanks, sumps, pumps, and transfer lines. Allowing the spray solution to dry in the application equipmenl can result in residues that are more difficult to remove. Dried residues are extremely difficult to remove. To remove such dried residues, fill the affected equipment to capacity with commercial tank cleaner solution and let it remain for 7 days. Afterwards, the equipment will need to be thoroughly flushed and rinsed.

Filename: Thidiazuron-Diuron EC (333-RED 020507) ADOS I 508 RED + PR 2007-4 (Clean).doc 

### Page 7RED 

### + PR Notice 2007-4

Spray application equipment that has been inadequately cleaned will contain residue of 

### THIDIAZURONDIURON EC. Such improper cleaning could lead to crop damage in later applications.

Arysta LifeScience North America, 

### llC assumes no liability due to equipment that has not been properly cleaned.

Warranty and Disclaimer Statement The direclions for use of this product are betieved 

### 10 be adequate and musl be followed carefully. However, It is impossible to eliminale all risks associated with the use of this product. Such risks may arise from weather condltions, soil factors, Off-target movement, unconventional farming techniques, the presence of other materials, the

manner of use or application, or other unknown factors, all of which are beyond the control of Arysta LifeScience North America, LLC ("Arysta'), and can cause crop injury, injury to non-targel crops or plants, ineffectiveness of the product, or olher uninlended consequences. All such risks shall be assumed by the user or buyer. Arysta warrants that this product conforms to the chemicat description on the label and is reasonably fit for the purposes stated in Ihe Directions for Use, SUbject 

### 10 the inherent risks described above, when used in accordance w·lth the Direclions for Use under normal conditions. This warranly does not extend to the use of Ihis product contrary to label instructions or under condilions not reasonably foreseeable to Arysla, and is subject to the inherent risks described above.

TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ARYSTA DISCLAIMS ALL OTHER WARRANTIES, EXPRESSED OR IMPLIED, INCLUDING ANY WARRANTY OF MERCHANTABtLiTY OR FITNESS FOR A PARTICULAR PURPOSE. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ARYSTA, MANUFACTURER, AND SELLER DISCLAIM AND SHALL NOT BE LIABLE FOR ANY SPECIAL, tNCIDENTAL, INDIRECT, OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE, HANDLING, APPLICATION, STORAGE, OR DISPOSAL OF THtS PRODUCT OR FOR DAMAGES IN THE NATURE OF PENALTIES, AND THE USER AND BUYER WAIVE ANY RIGHT THAT THEY MAY HAVE TO SUCH DAMAGES. NO AGENT, REPRESENTATIVE OR EMPLOYEE OF ARYSTA IS AUTHORIZED TO MAKE ANY WARRANTY, GUARANTEE OR REPRESENTATION BEYOND THOSE CONTAINED HEREtN OR TO MODIFY THE WARRANTIES CONTAINED HEREIN.

TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, THE EXCLUSIVE REMEDY OF THE USER OR BUYER, AND THE TOTAL LIABILITY OF ARYSTA, MANUFACTURER, AND SELLER, SHALL BE LIMITED TO THE PURCHASE PRICE PAID, OR AT ARYSTA'S ELECTION, THE REPLACEMENT OFTHE PRODUCT.

Filename: Thidiazuron-Diuron 

### Ee (333-RED 020507) ADOS1508 RED + PR 2007-4 (Clean).doc 

### , ''',,' ,s'



### ,
, > • ,



### , , , " , >,

Page 8 

### , , , 

# .

, , , >



### , "

, 

## ,

, , , >THIDtAZURON·DIURONECCOTTONDEFOLIANTForAgriculturalUseOnlyACTIVEtNGREDlENTS:Thidiazuron:N.phenyl-N'-1,2,3-thidiazol-5-ylurea·..Diuron:3-(3,4-dichlorophenyl)-1,1-dimethylurea·......12%..6%..82%..100%OtherIngredients:..TOTAL.Contains1lb.Thidiazuronpergallonand0.5lb.OiuronpergallonKEEPOUTOFREACHOFCHtLDRENDANGER-PELIGROSiustednoentiendelaetiqueta,busqueaalguienparaqueselaexpl"rqueaustedendetalle.(tfyoudonotunderstandthislabel,findsomeonetoexplainittoyouIndetaiL)••••CLOTHING;••••••gastriclavage.lfineyes,eyeopenandrinse20minutes.r"Removecontactlenses,ifpresent,afterthefirst5minules,thencontinueRinseskinimmediatelywithminutes.15-20Ifpersonisnotbrealhing,call911oranambulance,thengiveartificlatrespiration,preferablyistreatmentadvice.Donotinducevomitingunlesstoldtodosobyapoisoncontrolcenterordoctor.orwaterifabletoswallow.""toancare.Havetheproductcontainerorlabetwithyouwhen.callL'1gacenterordoctororgoingfortreatment.FOR24-HOUREMERGENCYMEDICALCALi:.:1-&53-303-6952FORCHEMICALEMERGENCY:Spill,leak,fire,callCHEMTREC1-424-9300STATEMENTS,-_.._--,-........-HAZARDSTOHUMANSANDUUMI:;'kl<"AruMA!..;'DANGER'""Corrosive.Causesirreversibleeyedaruag;e.ski!)irfit?tiortDO:f'\.Otgetineyes,onskin,oronclothing."Filename:Tlridi'&zuron-Diurot!EC(333-REO020507)AOOS1508REO+PR2007-4(Clean).docRED+PRNotice2007-4ENVIRONMENTALHAZAROSDonotapplydirectlytowater,ortoareaswheresurfacewaterispresentortointertidalareasbelowthemeanhighwatermark.DonotcontaminatewaterwhendispOSingofequipmentwashwaterorrinsate.Thisproductmaycontaminatewaterthroughdriftofsprayinthewind.ThisproducthasahIghpotentialforrunoffforseveralmonthsormoreafterapplication.Poorlydrainingsoilsandsoilswithshallowwatertablesaremorepronetoproducerunoffthatcontainsthisproduct.Atevel,well-ma'mtainedvegetativebufferstr'IPbetweenareastowhichthisproductisappliedandsurfacewaterfeaturessuchasponds,streams,andspringswillreducethepotentialforcontaminationofwaterfromrunoff.Runoffofthisproductwillbereducedbyavoidingapplicationswhenrainfallisforecastedtooccurwithin48hours.Sounderosioncontrolpracticeswillreducethisproduct'scontributiontosurfacewatercontamination.Thischemicalhaspropertiesandcharacteristicsassociatedwithchemicalsdetecledingroundwater.Useofthischemicalinareaswheresoilsarepermeable,particularlywherethewatertableisshallow,mayresultingroundwatercontamination.STORAGEANDDtSposAt:Donotconlaminatewaler,food,orfeedbystorageordisposal.PESTICIDESTORAGE:Storethisproduclinacool,dryplaceinitsoriginalconlaineronly,Containershouldbeclosedwhennotinuse.Donotexposetheproducttoopenflameexcessiveheat.Storeinoriginalcontainerandkeepclosed.PESTtCIDEDtSPOSAL:Pesticidewastesareacutelyhazardous.Improperdisposalofe:<cesspesticide,spraymixture,orrinsateisaviolationofFederallaw.Ifthesewastescannotbedisposedofbyuseaccordingtolabelinstructions,contactyourStatePesticideorEnvironmentalControlAgency,ortheHazardousWasterepresentativeatthenearestEPARegionalOfficeforguidance.CONTAINERDISPOSAL:Nonrefillablecontainer.Donotreuseor refillthiscontainer.Triplerinsecontainer(orequivalent)promptlyafteremptying.Triplerinseasfollows:Emptytheremainingcontentsintoapplicalionequipmentoramixtankanddrainfor10secondsaftertheflowbeginstodrip.FillthecontainerY.fullwithwaterandrecap.Shakefor10seconds.Pourrinsateintoapplicationequipmentoraml:<tankorstorerinsateforlateruseordisposal.Drainfor10secondsaftertheflowbeginstodrip.Repeatthisproceduretwomoretimes.Offerforrecycling,ifavailableorpunctureanddisposeofinsan'ltarylandfill,orbyotherproceduresapprovedbyStateandlocalauthorities.PHYSICALORCHEMICALHAZAROSDonotuseorslorenearheatoropenflame.ToContainaSpin:AbsorbliquidbycoveringijwithcatliUer,commercialclay,lime,sand,sawdust,orsodaash.Onceabsorbed,burythecleaningmaterialsandcleansethespillareawithadetergentandwatersolution.DIRECTIONSFORUSEItisaviolationofFederallawtousethisproductinamannerinconsistentwithitslabeling.SEEATTACHEOBOOKLETFORADDITIONALPRECAUTIONSANDUSEDtRECTlONSEPAReg.No.66330-333ManufactUredforEPAEstNo,51036-GA-001ArystalifeScienceNorthAmerica,LLCAD08150815401WestonParkway,Suite150________________________BASELABEL_Page9

### Date: August 27,2009

Reg. No.: 066330-333 Product Name: Thidiazuron-Diuron 

# Be

PM NameINumber: Joanne Miller, PM 23 /

/l/ ,.--/ 

## .GO ,-LO--c. 

# IV J 

### J 

### I c) 

## /0 

## 0; Primary Reviewer: Judy Loranger

## ~-a;, 

## ij**/~** AL-- f / ; 

## I. Secondary Reviewer: Larry Schnaubelt 

# L.**.Y#~7** 

# / 1;1'l; 

# <>J

New label or date ofRD amended label: New, Received on 

### 116/09

Fonnulation Type: Liquid

Active Ingredient Assessed: Thidiazuronl120301

Other ai's in product NamelPC code: Diuronl035505

Noteta PM: 

# • Reregistr:ation Status or Registration Date: Previous assessment attached.

1) PRE notes that the label for this product does not include resistance management labeling as described in PR Notice 2001-5. The Agency encourages registrants to add the resistance management grouping symbols and statements to product labels in view of the importance of resistance management to a long-term pest management strategy.

2) The respirator text appearing in the handler PPE section ("a NIOSH approved particulate filtering respirator equipped with N, R, P class filter media. The respirator should have a NIOSH approval number prefix TC-84A") differs from the respirator text required in the Diuron RED. The label assessor is uncertain whether this substitution is acceptable and defers to RD regarding this issue.

3) For clarification, RMIBV suggests that the first paragraph of the spray drift text required in the RED and which appears on the label be revised to:

"Thidiazuron products can not be applied by air within 

### Y2 mile of lettuce or withia 5 miles upwind of citrus in flush 

### (burst of new growth, as in springtime) in the Rio Grande valley of Texas. Ground applications are restricted to no less than 100 feet away from lettuce and no less than 

## Y2 mile upwind from citrus."

Also, this text should be moved from the Agricultural Use Requirements box and placed in the Spray Drift section. In 

### addition, RMIBV recommends that the general prohibition "Do not apply by air if sensitive crops are within 100 feet of the application site" (page 6) be qualified with the addition of the phrase"

... except as noted for lettuce and citrus" since without qualification the text would conflict with the lettuce and citrus restrictions.

1

### Assessment can be found N:\prb\label\066330/333a

1) 

### This product has been classified as a Restricted Use Pesticide due to eye irritation. Add the following text to the top of the front panel of the label, preferably enclosed in a box:

Restricted Use Pesticide

Due to eye irritation.

For retail sale to and use only by Certified Applicators or persons under their direct supervision and only for those uses covered by the Certified Applicator's certification.

The above text must be set in type of the same minimum size as required for human hazard signal words and appear with sufficient prominence relative to the other text and graphic material on the front panel to make it unlikely to be overlooked under customary conditions of purchase and use.

2) Add "Restricted Use Pesticide" immediately below the heading "Directions For Use",

3) Per the acute toxicity review and Thidiazuron and Diuron REDs, the handler PPE
must be revised to read:

"Some materials that are chemical-resistant to this product are made of barrier laminate

or butyl rubber. If you want more options, follow the instructions for category B on an EPA chemical-resistance category selection chart.

Pilots and flaggers must wear: Long-sleeved shirt and long pants, Shoes and socks.

Mixers, loaders, applicators and other handlers must wear: Coveralls over short-sleeved shirt and short pants, Chemical-resistant shoes plus socks, Goggles or faceshield, Chemical-resistant gloves, Chemical-resistant headgear for overhead exposure, Chemical-resistant apron when mixing, loading, or cleaning equipment or spills, A NIOSH approved particulate filtering respirator equipped with N, R, or P class filter media. The respirator should have a NIOSH approval number prefix TC-84A. It is recommended that you require that the respirator wearer be fIt tested, and trained in the

use, maintenance, and limitations of the respirator.

See engineering controls for additional requirements."

2

### 4) Additional text in 

### bold type must be added to the text:

"Maximum application rate of 0.3 lbs ai 

### thidiazuron per acre per year. Maximum of 2 applications, but not to exceed 0.3 lbs ai 

### thidiazuron per acre per year."

Per the Thidiazuron RED, add "Maximum Thidiazuron application rate is 0.125 lbs ai/A (under normal conditions) or 0.21bs ai/A (under variable conditions)."



## 3

### July 13, 2007 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF
PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES



### MEMORANDUM:

Subject:

From:

Through:

To: DiuronRED Thidiazuron-Diuron EC Cotton Defoliant EPA Reg. No.: 66330-333 Re: PRE Preliminary Label Assessment

Judy Loranger 

## (Signed/JL!7I24107) Product Reregistration Branch Special Review and Reregistration Division (7508P)

Lawrence Schnauhelt 

## (2"ILSI7!20107) Product Reregistration Branch Special Review and Reregistration Division (7508P)



### Joanne Miller, Product Manager 23 Herbicide Branch Registration Division (7505P)

### SCOPE: The primary purpose of this preliminary label assessment is to determine whether or not the draft labels submitted in connection with product reregistration comply with amended labeling language specifIed in Chapter V of the subject RED/IRED.**Product~specific** 

### data (product chemistry, acute toxicity, and in some cases efficacy data) were also required to be 

### submitted or cited to support product reregistration. PRB's reviews of these data are appended to this assessment and may require additional revisions to the product label.

BACKGROUND: The registrant has submitted 5 copies of draft labeling for the subject product in its 8-month response to the RED/IRED. PRB has completed a preliminary

assessment of the draft labeling. A copy of this assessment may be accessed electronically on the LAN through the Q-Drive. The path is q:lprbllabeII066330/333.

Note: In addition to the infonnation presented in this preliminary label assessment, Product ManagerlLabel Reviewers must apply their own knowledge of the subject product and the product's regulatory history (including comparison with existing stamped accepted labeling) to conduct a final review of the proposed label. 

### It is the responsibility of the PM to obtain the necessary label improvements required for final product reregistration.

Please note that this product contains multiple active ingredients. Additional label reviews will be necessary when the RED is issued for the other active ingredient (Thidiazuron.)

PRB recommends that the PMs continue to follow the guidance provided in the Label Review Manual, including formatting suggestions presented in the sample labels in Chapter 3, to improve the quality and consistency of product labels.

RECOMMENDATIONS:

The subject product requires revisions to conform with the RED and acute toxicity review. Deficiencies are listed in the table below. Once these revisions have been submitted and approved by the PM, the PM may issue an amended registration. Since this product contains mUltiple active ingredients it may not be reregistered until a favorable registration eligibility decision is made for all active ingredients. At that time the more restrictive language must be adopted for the label.



### 2

### Appendix I

PRB Label Analysis For Compliance With Label Revisions Specified In the REDIIRED and/or Technical Reviews

Label Requirement Acceptable Not Acceptable Comments Restricted Use Pesticide Per the acute toxicity review, this product meets the criterion for restricted

use classification based on data that place it in toxicity category I for eye irritation. Ingredients Statement 

### X Signal Word 

### X First Aid 

### X Based on toxicity ranking noted in the
acute toxicity review, PRB recommends that the First Aid statements be placed

on the label in the following order:

"IF IN EYES

... IF ON SKIN OR CLOTHING

... IF INHALED

... IF SWALLOWED

... 

### " Emergency Information 

### X
Note to Physician 

### X PRB recommends that the Note to Physician be revised to address eye irritation concerns. Hazards to Humans and 

### X Per the acute toxicity review, the Domestic Animals Hazards to Humans and Domestic Animals must be revised to read:

"DANGER Corrosive. Causes irreversible eye damage. Causes skin irritation. Do not get in eyes, on skin, or on clothing."
PPE 

### X Per the acute toxicity review and the Diuron RED, and Page IO-I6 of the label review manual, the PPE section must be revised to read:

"Some materials that are chemicalresistant to this product are made of barrier laminate or butyl rubber. If you want more options, foliow the instructions for category C on an EPA chemical-resistance selection chart.

All pilots and flaggers must wear: Long-sleeved shirt and long pants, Shoes and socks.

All mixers, loaders, other applicators and other handlers must wear:



## 3

### Label Requirement Acceptable Not Acceptable Comments

Coveralls over short-sleeved shirt and short pants, Socks plus chemical-resistant footwear, Chemical-resistant gloves, Goggles, face shield or safety glasses, Chemical-resistant apron when mixing, loading or cleaning equipment or spills, 

### ond Chemical-resistant headgear for overhead exposure. In addition to the PPE above, all handlers except for ground boom applicators, pilots and flaggers must also

wear a NIOSH-approved dust/mist filtering respirator with any N, R, P of HE filter or a NIOSH-approved dust/mist filtering respirator with approval number TC-2I 

## c."

Note to PM: The PPE specified in the RED has been revised as required in the acute toxicity review and the label review manual to require double layer PPE plus eyewear for all handlers including ground boom applicators. Engineering Controls 

### X
User Safety 

### X Because coveralls are required for some Requirements handlers PRE recommends that the following text be added to the User Safety Requirements:

"Discard clothing and other absorbent materials that have been drenched or heavily contaminated with this product's
concentrate. Do not reuse them." User Safety 

### X Recommendations Environmental Hazards 

### X The phrase "For terrestrial Use" erroneously appearing on Page 5 of the Diuron RED label table and also on the label is confusing and should be deleted from the label. Physical and Chemical X 

### Hazards WPS text 

### X Non-WPS text N/A 

### Storage and Disposal 

### X Spray Drift Labeling 

### X General Precautions and 

### X Restrictions Application Instructions Per Page 12 of the Diuron RED, the following text was required for use on



## 4

### Label**R~quirement** 

### Acceptable Not Acceptable Comments

cotton:

"Apply a maximum of three applications
per year."

Minimum retreatment interval is 21 days."

Note to PM: PRB is uncertain whether these restrictions are appropriate/needed for this pre-harvest defoliant use and defers to RD regarding this issue. Other Comments NIA



### 5

### DATE OUT: 171MAY/07

SUBJECT: PRODUCT CHEMISTRY REVIEW OF: TGAI []: MUP []: EUP [xl BARCODE NO.: 339926 REG.lFILE SYMBOL NO.: 66330-333 PRODUCT NAME:**Thidiazuron~Diuron** 

### EC COMPANY NAME: Arysta LifeScience North America Corp_

FROM: Maria Rivera Piansay, Chemist Product Chemistry Team PRB/SRRD (7508C)



### TO: Barbara Briscoe, CRM Product Reregistration Branch Special Review and Reregistration Division (7S08C)



### INTRODUCTION: ACTION CODE: 675

In response to our review of 5/1/07, Arysta LifeScience North America Corporation submitted revised basic and alternate formulation Confidential Statements ofFonnula (CSFs), both dated 5/8/07, "10 

### support of the reregistration of 

### Thidiazuron-Diuron EC, EPA Reg. No. 66330-333.

FINDINGS:

I. Previously, the registrant was requested to clarify the inconsistency between the basic and the alternate CSF in declaring the purity of the The basic CSF declared wh ile the alternate claimed The registrant responded by submitting revised CSFs showing

a different Diuron source. According to the current CSFs, the technical Diuron currently used in formulating this product is now**,** 

### , with a purity of

. With this revision, the CSFs are now found acceptable to support this product. The nominal concentrations of the active ingredients agree with that on the label, meeting PR Notice**91~2.** 

### The certified limits on the active and inert ingredients are acceptable as per 40 CFR 158.17S(b)(2). All ingredients Hsted on the CSFs are cleared for use in pesticide form1llations.

2. The Ingredients statements are in compliance with the requirements of 40 CFR 156.1 O(g). The Physical or Chemical Hazards subheading is not triggered based on the physical/chemical characteristics ofthe product. The Storage and Disposal section of the label is acceptable in accordance with 40 CFR 156.10 (i)(2)(ix).



### CONCLUSIONS:

The registrant has now satisfied product chemistry data requirements for the reregistration of EPA Reg. No. 

### 66330-333.

M.R. Piansay and Cenlral File (EPA Reg. No. 66330-333) 7508C:SRRD: PRB:CM-2: M.R.P

.. (17/MA Y 107):703-308-8063 :<66330-333>

### DATE OUT: OllMAY/07

SUBJECT: PRODUCT CHEMISTRY REVIEW OF: TGAI 

### [I; MUP 

### [I; EUP 

### [xl BARCODE NO.: 336741 REG.IFILE SYMBOL NO.: 66330-333 PRODUCT NAME: Thidiazuron-Diuron 

### Ee MRID NOS.: 462364-01. 462364-03, 462364-04 COMPANY NAME: Arysta 

### UfeScience North America Corp. ACTION CODE: 674

FROM: Maria Rivera Piansay, Chemist Product Chemistry Team PRBISRRD 

### (7508C)

TO: Barbara Briscoe, CRM Product Reregistration Branch Special Review and Reregistration Division (7508C)



### INTRODUCTION:

A Reregistration 

### Eligibility Decision (RED), Case number 0046, was issued 

### in September, 2003 for the Technical Grade Active Ingredient (TGAI) Diuron. According to the RED, the generic data base supporting the reregistration of Diuron have been reviewed and found to be substantially complete.



### In 

### the 8-month response to the Diuron RED, Arysta LifeScience North America Corporation submitted a basic and an alternate formulation Confidential Statement of Formula (CSF), dated 

### 2/5/07; a draft 

### label, EPA received 

### 2/8/07; and product chemistry data in MRID numbers 462364-0 1,**462364~03** 

### and 462364-04. The registrant is requesting FIFRA Section 4 reregistration ofTbidiazuron-Diuron EC, EPA Reg. No. 66330-333.



### FINDINGS:

1. 

### EPAReg. No.**66330~333** 

### is an**end~use** 

### product that contains Diuron and Thidiazuron from registered

sources (EPA Reg. No.**66330~324** 

### and respectively) at label claim nominal concentrations of 6.0% and 12.0%, respectively.

2. The CSFs for the basic and the alternate formulations are not acceptable at this time because of an inconsistency in the purity of the The basic CSF declares while the alternate claims The registrant must clarify this discrepancy.

3. The product chemistry data presented in MRID numbers**462364~01, 462364~03,** 

### and**462364~04** 

### are adequate and satisfy the product chemistry data requirements under Subgroups A and B which pertain to Product Identity, Composition and Analysis, and Physical and Chemical Properties, respectively.

4. The Ingredients statements are in compliance with the requirements of 40 CFR 156.10(g). The Physical or Chemical Hazards subheading is not triggered based on the physical/chemical characteristics of the product. The Storage and Disposal section of the label is acceptable in 

### accordance with 40 CFR 156.10 (i)(2)(ix).

CONCLUSIONS: Except for Finding 2, the registrant has satisfied product chemistry data requirements for the reregistration of EPA Reg. No. 66330-333.



### TillS REVIEW CONTAINS F1FRA CBI

## 2

REVIEW OF PRODUCT CHEMISTRY DATA: PRODUCT NAl\1E:**Thidiazuron~Diuron** 

### EC EPA Reg. No: 66330-333 Group A: Series 830-Product Identity, Composition, and Analysis (40 CFR158.155, .160, .165, .167, .170, .175 & 

### .180).**830~1550** 

### Product Identity and Composition

EPA Reg. No. 66330-333 is an end-use product produced through a non-integrated formulation system. The active ingredients Diuron and Thidiazuron are claimed 

### in the label at 6,0% and 12.0%, respectively. Description of materials used 

### in the formulation oftbis product is found in MRID number 459373-01 and on the CSF.

830-1600 Description of Materials Used to Produce the Product

Refer to Confidential Appendix A.



### 830-1620 Discussion ofFonnulation Process

Refer to Confidential Appendix 

### A.



### 830-1670 Discussion of Fonnation ofhnpurities

Refer to Confidential Appendix 

### A.

830-1700 Preliminary Analysis

Refer to Confidential Appendix A

830-1750 Certified Limits

Refer to Confidential Appendix A.



### 830-1800 Enforcement of Analytical Method

The registrant cited a validated analytical method for the analyis ofDiuron and Thidiazuron (MRID number 468773-02). The active ingredients are extracted from the formulated product using methanol, and analyzed by HPLC with detection by UVNis absorption. This analytical method had been previously reviewed and accepted and determined to satisfy GRN 830.1800.



### TillS REVIEW CONTAINS FIFRA CBr

## 3

Product Chemistry Data 

### Subgroup A: Series 830.1550·830.1800 (40 CFR 158.155·158.180)

GUIDELINE REFERENCE NO. MRIDNumber Data 

## (GRN)f TITLE 830 Fulmled

.1550 Product Identity and Composition 

### 462364·04 Y

.1600 Description of Materials Used to 462364·04 Y Produce the Product

.1620 Descriotion of Fonnulation Process 462364·04 Y

.1650 Discussion of Formation of 

### 462364·04 Y Impurities



### .1700 Preliminary Analysis 

## NfA NfA

.1750 Certified Limits 462364·04 and CSF Y

.1800 Enforcement Analytical Method 462364'()4 y



### Subgroup B: Series 830.6302

. 7950 (40 CFR 158.190)

GUIDELINE REFERENCE VALUE OR NO. QUALITATIVE 

### MRID Data Fulfilled 

## (GRN)f TITLE 830 DESCRIPTION Number



### .6302 Color Amber 

### 468773'()1 Y

.6303 Physical State Liquid at 25°C 

### 462364·01, ·03 Y

.6304 Odor Amine 

### 468773·01 y



### .6314 OxidationIReduction: Chemically stable to the action 

### 462364·01, ·03 Y Chemical Incompatibility afwater, Iron powder, and Monoammonium phosphate The test material underwent a mild oxidation reaction 

### in the
presence of a potassium pennanganate solution.



### .6315 FlammabilitylFlame Y Extension 

### >93 Q 

### C 462364·01, ·03

.6316 Explodability 

## NfA NfA 462364·01, ·03

## 4

.6317 Storage Stability Post-storage (duplicate) 

### 468773-02 

### y analyses of the product (oneyear, room-temperature 

### storage) yielded Diuron results ranging from 

### 5.92 to 

### 6.18% with an average of 

### 6.02%. Thidiazuron results ranged from 11.83 

### to 12.12% 

### with an average of 11.96%.



### .6318 Viscosity 

### 70 mpas 

### @ 25°C 462364-01 

### Y

64 

### mpas@ 25°C 

### 462364-03

.6320 Corrosion Corrosion testing was 468773-02 

### Y Characteristics conducted 

### in combination with the Storage Stability testing. 

### Product container (HDPE) retained its original condition after one year of storage at

room temperature.



### .6321 Dielectric Breakdown 

### N/A



# --- NlA Voltage

.7000 pH 

### 5.60@25°C 462364-01 

### Y

5.46@25°C 462364-03
.7300 Densitr;lRelative 

### DensitylBulk ensity 0.9935 glmL@25°C 462364-01 

### Y

0.9938 g/mL (a), 

### 25°C 462364-03

Explanations: Y = 

### Requirement fulfilled; N = 

### Requirement not fulfilled; N/A = 

### Not applicable; G = 

### Data gap



### THIS REVIEW CONTAINS FIFRA CBI

## 5

Confidential Appendix A

M.R. Piansayand Central File (EPA Reg. No. 66330-333) 7508C:SRRD:P RB:CM -2: M.R.P.: (0 lIMA Y f07):703M308-8063:<66330-333>



## THIS REVIEW CONTAINS FIFRA CBI

### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

February 21,2007

MEMORANDUM:

Subject:



### From:

To:

Applicant: 

### EPA Reg. No.: 66330-333/Thidiazuron-Diuron EC DP Barcode: 336474 Case No.: 0046



### Marianne Lewis, Biologist [sign. M.Lewis 2121107] Product Reregistration Branch Special Review and Reregistration Division (7508C)



### Barbara Briscoe, CRM Product Reregistration Branch Special Review and Reregistration Division (7508C)

Arysta LifeScience North America Corp, 

### 15401 Weston Parkway, Suite 150 Cary, NC 27513

FORMULATION FROM EPA Reg. No. 66330-333 LABEL:

Active IngredientCs): OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES



### % 

### bywt.



### Diuron

............................................................................................................. ..... . 6.0% 12.0% 82.0% 

### 100.0% Thidiazuron

................................................................................. . Inert Ingredient(s):

................................................................................................ . Total

### BACKGROUND: In the 8 month response to the Diuron RED, the registrant has submitted acute toxicity studies to support the reregistration of their product, EPA Reg. No. 66330-333. 

### The MRlD's are as follows: 468773-03 (81-1),468773-04 

### (81-2), 468773-05 

### (81-3), 468773-06 (81- 4),468773-07 (81-5), 468773-08 (81-6). The studies were conducted by Product Safety Labs. The test material used in each of the studies was the subject product.

The primary eye irritation study (81-4) is self validated as Toxicity Category I therefore a full review of this study will not be conducted at this time by the Agency.

RECOMMENDATIONS:

• Five (81-1, 81-2, 81-3, 81-5, 81-6) of the acute toxicity studies submitted are acceptable to support the reregistration of EPA Reg. No. 66330-333.

• The primary eye irritation study (81-4) is self validated as Toxicity Category L

The acute toxicity profile for EPA Reg. No. 66330-333 

### is currently:

Acute Oral IV Acceptable Acute Dermal IV Acceptable Acute Inhalation IV Acceptable Primary Eye I Self Validated Primary Dermal II 

### Acceptable Skin Sensitization non sensitizer Acceptable

NOTE: The acute toxicity requirements have been satisfied for the subject product.

### DATA REVIEW FOR ACUTE ORAL TOXICITY (§81-1, 870.1100)

Reviewer: Marianne Lewis 

### Product Manager: Jim Tompkins, 25 MRlD No.: 468773-03 

### Study Completion Date: 5115106 

### Report No.: 19086



### Testing Facility: Product Safety Labs 

### Author: G. Moore



### Quality Assurance (40 

### CFR §160.12): 

### Included

Test Material: Thidiazuron-Diuron 

## Ee, amber liquid

Species: Sprague-Dawley derived albino rat Age: young adult 

### Weight: females = 

### 194

- 233 

### Source: Ace Animals, Inc.

Conclusion: Up & 

### Down Method



### 1. 

### LDso (mg/kg): > 

### 5000 mgikg



### 2. Toxicity Category: IV Classification: Acceptable



### Procedure (Deviations from §81-1): none

Results:

Test Sequence 

### Animalld Dose Level Short term 

### (mg/kg) outcome 

### 1 8256 5000 

### S 2 8282 5000 S 

### 3 8283 5000 S 

### S - SUrvIVal; 

### D - death Long term


### outcome 

### S S
S



### Observations: 3/3 

### piloerection, 1/3 

### hypoactive, 1/3 

### anD-genital staining, all active and healthy from day 3 to end of study.



### Gross Necropsy: No observable abnonnalities noted

### DATA REVIEW FOR ACUTE DERMAL TOXICITY (§81-2, 870.1100)



### Product Manager: Jim Tompkins, 25
MRID No.: 468773-04 Reviewer: Marianne Lewis Study Completion Date: 5115106 

### Report No.: 19087

Testing Facility: Product Safety Labs 

### Author: G. Moore

Quality Assurance (40 CFR §160.12): Included

Test Material: Thidiazuron-Diuron 

## Be, amber liquid Species: Sprague-Dawley derived albino rat Weight: males**~** 

### 328

- 343 g; females**~** 

### 218

- 230 g Age: young adul t 

### Source: Ace Animals, Inc.



### Summary:

1. 

### LDso (mg/kg): > 

### 5000 mglkg



### 2. Toxicity Category: IV 

### Classification: Acceptable

Procedure (Deviations From §81-2): none

Results: 

### Reported Mortality

(number deaths/number tested) DOSAGE 

### (mglkg) 

### Males Females Combined



### 5000 015 015 0110



## . ObservatIOns: Twenty four hours pnor to applrcatron of the test matenal the dorsal area and trunks were clipped free of hair. The neat test material was applied evenly over a dose area of


### approx. 2 x 3 inches (approx. 10% 

### of total body surface) and covered with 2 x 3 inch**4~ply** 

### gauze pad. The pads and trunks were wrapped with a 3 inch Durapore tape. After 24 hours, the wraps and pads were removed and the test sites were gently cleansed.

10110 

### exhibited erythema & 

### edema, 7110 

### desquamation (lasting throughout the study)

- apart from these signs all appeared active and healthy for the duration of the study.

Gross Necropsy Findings: No observable abnonnalities were noted.

### DATA REVIEW FOR ACUTE INHALATION TOXICITY TESTING (§81-3, 870.1300)

Reviewer: Marianne Lewis Product Manager: Jim Tompkins, 25 MRID No.: 468773-05 

### Study Completion Date: 5/15/06 

### Report No.: 19088



### Testing Facility: Product Safety Labs 

### Author: G. Moore

Quality Assurance (40 CFR §160.12): Included

Test Material: Thidiazuron-Diuron EC, amber liquid

Species: Sprague-Dawley derived albino rat Weight: males**~** 

### 316

- 326 

### g; 

### females**~** 

### 209·244 g 

### Age: young adult Source: Ace Animals, Inc.

Summary:

1. LC 

### so (mglL): > 2.01 

### mglL

2. MMAD: 3.0**~m** 

### GSD: 1.75



### 3. Tox. Category: IV Classification: Acceptable

Procedure (Deviation From §81-3): none

Results: Reported Mortality

Exposure (number deaths/number tested) Concentration Males Females



### 0.52 

## mg/Lc3' 0/5 2.01 

## mglL 2/5 

## liS

Chamber Atmosphere
Dose Level mgIL 

### MMAD GSD 0.52 2.8**~m** 

### 1.75
2.9**~m** 

### 1.75
2.01 2.9**~m** 

### 1.72 3.0**~m** 

### 1.75 combined

3/10

### Chamber Dose Level rng/L Dose Level rng/L Environment 0.52 2.01 

### Chamber Volume 150 

### L 150 

### L Airflow 

### 45.7 45.7 Temperature CC) 

### 21- 22 21

- 22 Relative Humidity % 

### 42

- 68 42 -70



### Clinical Observations:

Dose mg/l Time of Death Clinical Observations 0.52 N/A 

### 115 irregular respiration, dry rales, hypoactive, all active and healthy from day 2 to end of study 2.01 3/10 

### on day 2 Reduced fecal volume, hunched posture, hypoactivity, irregular respiration, moist rales, facial staining, red ocular discharge, 

### 6/10 (survivors) lost weight during first half of study

- all gained by end of studY

Gross Necropsy Findings:

Dose mglL Gross Necropsy Observations 0.52 

### No observable abnormalities noted. 2.01 

### Decedents: lungs slight edema, red intestines; survivors: no observable abnormalities noted

### DATA REVIEW FOR SKIN IRRITATION TESTING (§81-5, 870.2500)



### Product Manager: Jim Tompkins, 25
MRID No.: 468773-07

Testing Facility: Product Safety Labs 

### Author: G. Moore

Quality Assurance (40 

### CFR §160.12): 

### Included Reviewer: Marianne Lewis Study Completion Date: 

### 5115/06 Report N<1.: 19090

Test Material: Thidiazuron-Diuron Ee, 

### amber liquid



### Dosage: 0.5 mL Species: New Zealand albino rabbit 

### Age:**yo~ng** 

### adult Sex: 3 males Weight: not given Source: Robinson Services, Inc.

Summary:

1. 

### Toxicity Category: 

### 11

2. Classification: Acceptable

Procedure (Deviations From §81-S): none

Results: Twenty four hours prior to application of the test material the dorsal area and trunks

were clipped free of hair. The test material was applied to one 6 cm 2 

### intact dose site and covered with a I x 1 inch 4-ply gauze pad and wrapped with 

### 3 inch Micropore tape. After 4 hours the pads and wrappings were removed and the test sites were cleansed.

At I hr., 113 very slight erythema, 2/3 well defined erythema, & 

### 3/3 very slight edema. From 24

to 48 hrs., 2/3 well defined erythema, 1/3 moderate to severe erythema, & 

### 3/3 slight edema. At 72 hrs., 3/3 well defined erythema, 3/3 slight edema, & 

### 2/3 hyperkeratosis. On day 7, 3/3 very slight erythema, 3/3 very slight edema, & 

### 3/3 desquamation. On day 10, 3/3 very slight erythema, 2/3
very slight edema, & 

### 3/3 desquamation. By day 14, 3/3 very slight erythema & 

### desquamation.

### DATA REVIEW FOR DERMAL SENSITIZATION TESTING (§81-6, 870.2600)

Product Manager: Jim Tompkins, 25
MRID No.: 468773·08

Testing Facility: Product Safety Labs Author: G. Moore

Quality Assurance (40 CFR §160.12): Included Reviewer: Marianne Lewis Study Completion Date: 5115106 

### Report No.: 19091

Test Material: Thidiazuron-Diuron 

## Ee, amber liquid

Positive Control Material: HCA historical control (PSL # 18271, 10-14-05)

Species: Hartley albino guinea pig Weight: males**~** 

### 297

- 380 g Age: young adult Source: Elm Hill Breeding Labs

Method: Buehler

Summary:

1. This Product is a non sensitizer



### 2. Classification: Acceptable

Procedure (Deviation From §81-6): none

Procedure:

A 

## group of animals were used to determine the highest non-irritating concentmtion (HNIC) of the

test substance prior to the challenge dose. The HNIC for the test substance was detennined to be 6% w/w 

### mixture in mineral oil.

The test animals were induced with 0.4 ml of75% test material in mineral oil once a week for three weeks using a Hill Top Chamber. Twenty four hours after each induction dose the animals

were scored for irritation. Two weeks after the last induction dose, 0.4 ml of 6% w/w 

### of test material in mineral oil was used to challenge the test animals. Twenty four and 48 hours after the challenge the animals were evaluated for sensitization.

A group of ten animals were used as naive controls. These animals received only the challenge doses of the test material.

### Results: Due to irritation and residue adhesive from the tape the test sites were moved for the second and third induction doses.

Twenty four hours after the first induction dose for the test materialMinduced animals, 

### 5120 exhibited very faint erythema and 12/20 faint erythema. After the second induction dose, 

### 10/20 exhibited very faint erythema and 6/20 faint erythema. After the third induction dose, 

### 8120 exhibited very faint erythema, 9/20 

### faint erythema, and 1/20 

### well defined erythema at the test site.

Twenty four hours after challenge, 

### 8/20 test material-induced animals exhibited very faint erythema.

At 24 hours, in the naive control group of animals challenged with the test material, 411 0 exhibited very faint erythema.

### ACUTE TOX ONE-LINER

1. PC CODE: 

### 035505
2. CURRENT DATE: February21,2007 3. TEST MATERIAL: Thidiazuron-Diuron 

## Be, amber liquid Diuron: 6.0%, Thidiazuron: 12.0%

Study/Species/ MRID# Results Lab/Study#lDate

acute oral toxicity/ratIProduct 

### 46877303 LD50> 

### 5000 mglkg Safety Labs/19086/5-15-06

acute dennal toxicity/rat! 

### 46877304 LD50> 5000 mglkg Product Safety Labs/19087/ 5-15-06

acute inhalation toxicity/rat! 

### 46877305 LD50> 

### 2.0 I mgIL Product Safety Labs/19088/ MMAD**~** 

### 3.0**~m;** 

### GSD**~** 

### 1.75 5-15-06

primary eye irritation/rabbit! 46877306 Product Safety Labs/19089/ 5-15-06

primary dennal irritation/rabbit! 46877307 At I hr., 1/3 very slight erythema, 2/3 Product Safety Labs/19090/ well defined erythema, & 3/3 

### very slight 5-15-06 edema. From 24 to 48 hrs., 

### 2/3 well defined erythema, 

### 1/3 moderate to

severe erythema, & 

### 3/3 51 

### ight edema.
At 72 hrs., 3/3 well defined erythema, 3/3 slight edema, & 2/3 

### hyperkeratosis. On day 7,3/3 very slight erythema, 3/3

very slight edema, 3/3 desquamation. On day 10, 3/3 very slight erythema, 2/3

very slight edema, 3/3 desquamation. By day 14, 3/3 very slight erythema & 

### desquamation.

skin sensitization/guinea pig! 

### 46877308 Non sensitizer Product Safety Labs/19091/ 5-15-06

Core Grade Key:A

- Acceptable, S - Supplementary,U

- Unacceptable,V

-**self~Vahdated** 

## Tax. Core Cat. Grade



### IV A

IV A

IV A

I V



### 11 A

--- A

### LABELING:

ID #: 066330-00333 THIDIAZURON-DIURON EC

RESTRICTED USE CLASSIFICATION RECOMMENDED:

Due to primary eye irritation toxicity category.



### SIGNAL WORD: DANGER PELIGRO

HAZARDS TO HUMANS AND DOMESTIC ANIMALS:

Corrosive. Causes irreversible eye damage. Causes skin irritation. Do not get in eyes, on skin, or on clothing. Wear protective eyewear (goggles, face shield, or safety glasses), coveralls over short sleeved shirt and 

### short pants, chemical resistant shoes, socks, and chemical resistant gloves (barrier laminate or butyl rubber, selection category B). When mixing and loading wear a chemical resistant apron. For overhead exposure wear chemical resistant headgear. When cleaning equipment add a chemical resistant apron.

FIRST AID:

IF IN EYES: Hold eye open and rinse slowly and gently with 

### water for**15~20** 

### minutes. Remove contact lenses, if 

### present, after the first 5 minutes, then continue rinsing eye. Call

a poison control center or doctor for treatment advice.

IF ON SKIN OR CLOTHING: Take off contaminated clothing. Rinse skin immediately with plenty of water for 15-20 minutes. Call a poison control center or doctor for

treatment advice.

Have the product container or label with you when calling a poison control center or doctor or going for treatment. You may also contact 1-800-xxx-xxxx for emergency medical treatment infonnation.

USER SAFETY RECOMMENDATIONS:

User should wash hands before eating, drinking, chewing gum, using tobacco, or using the toilet.

User should remove clothinglPPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing.

Users should remOve PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing.

### The proposed label must contain the following guidance:



## NOTE TO PHYSICIAN:

Probable mucosal damage may contraindicate the use of gastric lavage.

Note to CRMIPMlRegistrant:

The proposed label should contain a Note to Physician which addresses the primary eye irritation Toxicity Category I. 

### The following statements are some suggested types of infonnation that could be included, if applicable, in the Note to Physicians:**~** 

### technical infonnation on symptomatology,

- use of supportive treatments to maintain life functions;

- medicine that will counteract the specific physiological effects of the pesticide;**~** 

### company telephone number to specific medical personnel who can provide

specialized medical advice.

# PRODUCT REREGISTRATION

SUPPORTING DOCUMENTATION

FORM

Case Name:

# .~ Registration No.

# aj"j~ 

# -333

This supporting documentation (in chronological order) includes:

o Old labels (identified as "Superceded by label dated xx/xx/xx)

o Unacceptable CSF (marked "Not acceptable" and dated)

o Product chemistry reviews

o Acute toxicity reviews



## o Efficacy and or special studies (if necessary)

o 90-Day responses to PDCI (forms A and B)

o Administrative forms (Application for Reregistration Celtification to Data citation, Data Matrix)

o Correspondence (Company and Agency letters & 

## e-mails)Please 1m Approved. OMS No. 2070·0060. Approval 

# & EPA United States 

### Environmental Protection Agency

. DC 20460 

# o Registration 

# o Amendment



### Application for Pesticide

- Section I

2. opp Identifier Number



# o None 

# 0 Restricted



### 6. Expedited Review. In accordance with FIFRA Section

Arysta LifeScience North America, LLC 15401 Weston Parkway, Suite 150 Cary, NC 27513 (b)(I), my product is similar or identical in composition and labeling to: EPA Reg. No.

___________ _
Product Name

_____________ __



### Section -II

Amendment

- Explain below. Final printed labels in response to
Resubmission in response to Agency letter dated

__ Ii I I 

### necessary.**8~Month** 

### Response to Data Call-In dated May 8, 2008 for product containing thidiazuron.**Yes~** No 

### Yes 

### Section

- III

poe 

### *Certification must Unit Packaging 11111. container Package wgt. poe container



## IS] label 

# D Container On label 2.5 gal., 5.0 gal., and 30 gat.



### Section -IV

BILL WASHBURN REGULATORY AFFAIRS MANAGER



## '" I certify that the statements I have made on this form and all attachments thereto are true, accurate and complete. I; acknowledge that any knowingly false or misleading statement may be punishable by fine or imprisonment or bolli'

, .**~** under applicable law.



### REGULATORY AFFAIRS MANAGER

BILL WASHBURN 

### 1/5/09 

# "" I I Paper
Other



### " 

# . 901-432-5118



# "Ut'u fED STATES ENVIRONMENTAL PROTEC I ION AGENCY 

### 401 M Street, S.W. 

### WASHINGTON, D,C. 20460 Form Approyed OMS No, 2070-006'

PapelWork Reduction Act Notice: The public reporting burden for this collection of information is estimated to average 1.25 hours per response for registration activities and 0.25 hours per response for reregistration and special review activities, including time for reading the instructions and completing the necessary forms. Send comments regarding the burden estimate or any other aspect of this collection of information, Including suggestions for reducing the burden to: Director, OPPE Information Management DiYision (2137), U.S, EnYironmental Protection Agency, 401 M Street, SW., Washington, DC 20460. Do not send the form to this address.

Certification with Respect to Citation of Data Applicant's!Registrant's Name, Address and Telephone Number EPA Registration Number! File Symbol Arysta LifeScience North America, 

### LLC, 15401 Weston Pkwy, Ste 150, Cary, NC 66330-333 Actiye Ingredient{s) andlor representative test compound(s); Date Thidiazuron, Diuron December 20, 2008
General use pattem(s) (list all those claimed for this product using 40 CFR Part 158) Terrestrial, Non-Food Use (Cotton) Product Name THIDIAZURON-DIURON EC

NOTE: If your product is a 100% repackaging of another purchased EPA·registered product labeled for all the same uses on your label, you do not need to submit this form. You must submit the Formulator's Exemption Statement{EPA Form 8570-27). 

# o I am responding to a Data CalHn Notice, and have included with this form a list of companies sent offers of compensation (the Data Matrix form should be used for this purpose).

SECTION I: METHOD OF DATA SUPPORT (Check one method only) 

# o I am using the cite·all method of support, and have included with this form a list of companies sent offers of compensation (the Data Matrix form should be used for this purpose). 

### [8J I am using the selectiye method of support (or cite-all option under the selectiye method), and have included with this form a**comple~;d** list of data requirements {the Data Matrix form must be used,.

SECTION II: GENERAL OFFER TO PAY
[Required if using the cite·all method or when using the cite·all option under the selective method to satisfy one or more data requirements] [2] I hereby offer and agree to pay compensation, to other persons, with regard to the approval of this application, to the extent required by FIFRA.

SECTION III: CERTIFICATION

I certify that this application for registration, this form for reregistration, or this Data Call-In Notice is supported by all data submitted

or cited in the application for registration, the form for reregistration, or this Data Call·ln response. In addition, if cite·all option under the selective method is indicated in Section I, this application is supported by all data in the Agency's files that (i) concem the properties or effects of this product or an identical or substantially similar product, or one or more of the ingredients in this product: and (2) is a type of data that would be required to be submitted under the data requirements in effect on the date of approyal of this application if the application sought the initial registration of a product of identical or similar composition and uses.

I certify that for each exclusiye use study cited in support of this registration or reregistration, that I am the original submitter or that I have obtained the written permission of the original submitter to cite that study.

I certify that for each study cited in support of this registration or reregistration that is not an exclusiye use study, either: (a) I am the original data submitter: (b) I have obtained the written permission of the original data submitter to use this study in support of this applicaflon: (c) all periods of eligibility for compensation have expired for the study; (d) the study is in the publlc literature; or (e) I have notified in writing the company that submitted the study and have offered (i) to pay compensation to the extent required 

### by sections 3(c){1 )(F) andlor 3{c)(2){B) of FIFRA; and (ii) to commence negotiations to determine the amount and terms of**compens'-lii~% !f~any,**  to be paid for the use of the study, ; , , ,**'~** , "


### , I certify that in all instances where an offer of compensation is required, copies of all offers to pay compensation and evidence of their delivery in accordance with sections 3(c){1 )(F) and!or 3(c)(2)(B) of FIFRA are available and will be suorrdtetllo the agegcy upon request. Should I fail to produce such evidence to the Agency upon request, I understand that the Agency ma'y,l\1liiate actj("ln Ip deny, cancel or suspend the registration of my product in conformity with FIFRA. , ) , ' , " ;

I certify that the statements I have made on this form and all attachments to it are true, accurCi'te:c.nd' complete: I acknowledge that any knowingly false or misleading statements may be punishable by fine or imprisonment or

### bot;'~u~dor applicable law. ' '.::

Signature Date Typal orPrintal Name am**Ti~e** 12/20/08 Bill Washburn, Regulatory Manager
EPA Fonn 8570-34 (9·97) Electronic and Paper versions aYaitable, Sllbmlt only Paper yerslon.Form approved. OMB NO. 2070-0060. E Approval t:xpires 1-30-93
United Slates Environmental Protection Agency 

## ft Washington, D.C. 20460 

# o EPA Formulator's Exemption Statement (40 CFR 152.85)
Applicant's Name and Address EPA File Symbol/Registration Number 

### Arysta LifeScience North America, LlC 

### 66330-333
Product Name 

### 15401 Weston Parkway, Suite 150 THIDIAZURDN-DIURDN EC Cary, NC 27513 Date of Confidential Statement of Formula (EPA Form 8570-4) 

### 12/20/08



### As an authorized representative of the applicant for registration of the product identified above, I here certify that:
(1) This product contains the following active ingredient(s): D!URON

(2) Of these, each active ingredient listed in paragraph (4) is present so!ely as the result of the use of that active ingredient in the manufacturing, formulation or repackaging of another product which contains that active ingredient, which is registered under F!FRA Section 3, is purchased by us from another producer, and is labeled for at least each use for which my product is proposed to be labeled.

(3) Indicate by checking (A) or (8) below which paragraph applies: 

# k8J (A) An accurate Confidential Statement of Formu!a 

### (EPA Form 8570-4) for the above identified product is attached to this statement. That formula statement indicates, by company name, registration number, and product name, the source of the active ingredient(s) listed in paragraph (1). OR 

# D (B) The Confidential Statement of Formula 

### (CSF) (EPA Form 8570-4) referenced above and on file with the EPA is complete, current, and accurate and contains the information required on the current CSF.

(4) The following active ingredients in this product qualify for the formulator's exemption.

Source

Active Ingredient Product Name Registration Number



### Diuron

Or



# · • " "



### , , 

## ·


# . '" 

# · · 

# · · 

# · · 

# .. '" ), 

## . 

# · 

# · ·

. '" ' 

# · · 

# · · 

# .. · ·

,)) 

### , 

### • Signature Name and Tille Date

# G.:..,woo~ Bm Washburn, 

### 1/3/09 

# · Regutatory Manager



## - - EPA Form 8570 27 (Rev. 7 91)



## - White EPA copy Yellow Applicant copy


## -

# PRODUCT **REREGISTRATION**

**SUPPORTING DOCUMENTATION** 

**FOR**

Case

# Name:_~~~_______ ___ ...

This supporting documentation (in chronologicol oreJer) includes

Old labels (Identdied 05 

### "Superceded bv /ot)ef (jc/eo'

### fJ,'xx/!~ ,J 

# " Unacceptable C:SFs [morkeo 'Not Accept')/)!e unci ciCJteO)

u 

# Product chemistry reviews Acute Toxicity reviews

j 

# Efficacy reviews (if 

# necessary)
(!? 

# 90-day responses to PDC I if orrn f., 

# ono form B)

### ,~ 

## Administrative forms (Application lor Rer8Qlstr01ion, 

### CerlillcoliO(l
to [Jato Cltotlon, 

### Dolo Motrc.:)


## Il 

# COtrespondence

# Material to be added to a Mini-Jacket (in the case where an e-Jacket exists)

Reg. No.



# Send to SIG: check box 

# 0

This material is:

€ 

# New stamped-accepted label 

# € NewCSF
€ 

# Notification
€ 

# Final Printed Label

€ 

# Other:



# Instructions: Attach this notice on top of the material. It must be clipped all together and there should be NO STAPLES in the material. Then give the material with this coversheet to staff in the Information Services Center (Room 

# 230).

Reviewer's Name:

Phone:

_____ Division:

___ _

CUrrent as of Monday, July 10, 2006

# ~**"~~;;::~~~~=i'O====7r====02IE~i6Qii,,cc~~I----, ~**  C>

## I";~~~;~ C> C> "-

### Certifier! 

### Mail Provides:**~** A m8,(ing**",e~ipt**

ill /\ Sig"3IW" '!Pen**de;'v~rl** III A reCOICl Of del"_'e'Y kcel 1>\' !hi'**Pw,~'** S0Cv'ce for I'NG Y":l<S
ImDort'mf Remindars: l!!**-C~r:':;t(l ;,1~':**  "'"y CHLY '.",**'~'C" ,\,~",,,(j**  "

..**,i\~ F,"~t-C:**  lSS ",!ai! o! Pr,onty tv1ail.

2 CO'n'i'2d r.I'!!: ':, "ot ')\'C,::1cO;,. 'e" C),','i**:)a~:;** 0A ',',Y"-,, ,C1'.',M,'"**rC,3:~**



# • CCVERN:;C0 IS P?O',!iDEf) ;M;r;,0 ;J.'-,:, O!,I 'if':" (; e, F[('**wt~!Gl)**

IJt' kstc:C!c'rJ :0 trw Jdd'B,)3e'a Or

c'" ,',l;;" 'n;:;'"**!h~** rn<lrlplEOe "lith the

IMPORTANT: S<l'J8 Hiis receipt and present jj wilen making an inqui/Y.SYMBOL

SURNAME

DATE 

# )

UNITED STATES EHVIRONMENTAL PROTECTIOH AGEHCY

CERTIFIED MAIL

Mr. Bill Washburn, Regulatory Affairs Manager 

### Micro Flo Company P.O. Box 772099 

### Memphis, TN 38117 '.-

SUBJECT: Diuron, Reregistration Eligibility Decision, (RED), Product Specific Data Call In Notice, Deficient Response to Data Ca1i in Requirements 

### EPA Registration Number 51036-429 (transferred to 66330-33)

Dear Mr. Washburn:

This letter serves as notification to you that Micro Flo Company is not 

### in compliance with the Diuron RED, Product Specific Data Call In Notice. SpecificalIy, you failed to submit copies of the Confidential Statement of Fonnula for your product. Additionally, you are required to submit revised copies of draft labeling and Application for Reregistration (Fonn 8570-1) which reflects the transfer of
your EPA Registration Number 51036-429 to EPA Registration Number 66330-33.

The fonns are available on the EPA website, hUp://www.epa.gov!opprdOOllforms. You must submit the data indicated above within ten days from your receipt of this letter. A Notice of Intent to suspend your Diuron product, EPA Reg. Number 66330-33 may be issued 

### if you fail to meet this time frame. If you have any questions, please contact Barbara Briscoe at 703-308-8177.

Sincerely,

Linda S. Propst, Chief Product Reregistration Branch Special Review and Reregistration Division

COHCUItRIHC!$

................. d 

# ::U.. 9.J{.!;:

............... .. .................................. _ ................. u .................................. .



## .................. ... :',.-.**;.~7:** 

## ................. .**ljft~'** 

# . .............**~** 

# .. ................... 

# _............... 

# ._ ............ .. .................IY1oI80L.

IUAHAME

"ATE CERTIFIED MAIL

Mr. Bill Washburn Regulatory Affairs Manager 

# MAY 3 2007

Arysta Life Science North America Corporation 15401 Weston Parkway, Suite 150 

### Cary, NC 27513

SUBJECT: Diuron, Reregistration Eligibility Decision (RED) Review of Product Chemistry Data, 

### EPA Registration Number 66330-333

Dear Mr. Washburn:

This letter is in regard to your submission of product chemistry data in response to the Diuron (RED) Product Specific Data Call-In Notice. The Agency has made the following detenninations:

• The Confidential Statements of Fomlula, (CSF) for the basic and alternate fonnulations dated February 5, 2007 are not acceptable at this time because of an inconsistency in the purity of the The basic CSF declares while the alternate claims You must clarify this discrepancy.

• The data you submitted in MRlD numbers 46236401, 46236403 and 46236404 are adequate and satisfy the product chemistry data requirements under Subgroups A and B which pertain to Product Identity, Composition and Analysis, and Physical and Chemical Properties.

• The Ingredient statements on the draft label are in compliance with the requirements of 40 CFR 156.10(g) and PR Notice 91-2. The Physical or Chemical Hazards subheading is not triggered based on the physical/chemical characteristics of the product. The Storage and Disposal section of the label is acceptable in accordance with 40 CFR I56.1O(i)(2)(ix).

You are required to submit revised CSF(s) within 

### 10 days from your receipt of this letter. Failure to submit this data within this time frame may result in your receiving a Notice of Intent 

### to Suspend your product. A copy of the Agency's Data Evaluation Record is enclosed. If you have any questions, regarding this letter you may contact Barbara Briscoe at 703-308-8177.

# _.~!1. 

# .......**~**

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# l-:Sl:~~ ...**~/ill)\·** 

# ................. JJ; 

# 01 Sincerely,

Linda S. Propst, Chief Product Reregistration Branch Special Review and Reregistration Division

COHctJllUtlHetS



# . ..................

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### OF FICIAL FILE COPY**"U.$.~P""""OOfb:** 11182- s:zo.8W4007Please read instructions on reverse before campl<- 

# J form.
, .... rm Approved, OMB No. 2070-0060, Approval 

### e,,',.,



# - EPA United States 

### D Registration opp Identifier Number 

# 0 Environmental Protection Agency 

### D Amendment Washington, DC 20460 Other:

A for Pesticide

- Section I

# ~ cl Nombe,

# ~ 3. 

### I

; EC

## ~~. 

# o None 

# o Restricted



### 5. N,me '" oof 

# " " (tooode (b)(I), my product is

# si;":~ar or identical in

# ~:~position**~n~ ~{,c)~~~~**  Arysta UfeScience North America Corporation to: 15401 Weston Parkway, Suite 150 EPA Reg. No. Cary, NC 27513 

# o Check if this is 

### a new address Product Name

Section

- II

Amendment

- Explain below. Final printed labels in response to Agency lettel dated
Resubmission in response to Agency tetter dated 5/3/07 

# J "Me Too" Application



# ,

- E'pl,'o below. I Other

- Explain below Explanation: Use additional 

### if necessary. (For 

### i 

### 1 I and 1 

### II.)

Resubmission on response to Agency letter dated 513107. Clarification of source of active on Alternate Formulation dated 51S107. Source corrected to

Section

- 

### III

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# ,**~I"** 

### Soloble "--,Type 

# 8'

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# F Yes y., Metal


### No 

## No

# "~ Plastic

## u~~e.,s:' wgt. No.

### 'p~r No. per Gtass 

### *Certification must 

# , wgt. container Paper 

### be submitted I 

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# , I 4. 81,e(,) 

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### ; Poiol ybefow 

### ,flo be 

# ,**N~7~L** WASHBURN ITHle

# c~~~i ; No. (Ioolode "'eo REGULATORY MANAGER 

### 901-432-5118**~"'"** 

### I , ,,6. 

### Ii 

### I the statements I have made on this form and all aUachments thereto are true, accurate and complete. j 

# J. I that any knowingly false or misleading statement may be punishable by fine or imprisonment or both 

### ,(StaQ'ped) JJ""

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# ~;~~LATORY MANAGER ) 

### , , 

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### May 10, 2007 '''.'



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### 8-94) : 

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# , I YOlld,,- I 'Copy

# e

Arysta LifeScience

May 10, 2007

Ms. Linda S. Propst Product Reregistration Branch Special Review and Reregistration Division Office of Pesticide Programs

- 7508P U.S. Environmental Protection Agency One Potomac Yard (South Building), Room S-4400 2777 South Crystal Drive Arlington, VA 22202



### Subject: Thidiazuron-Diuron EC EPA Reg. No. 66330-333



### Response to Agency Letter dated May 3, 

### 2007

Dear Ms. Propst:



### Having completed my review afthe Alternate CSF dated February 5, 2007, 

## it appears that the source of the active ingredient diuron was not identified properly. The source for the diuron has been properly identified on the enclosed Alternate Confidential Statement of Formula dated May 8, 2007.

Should you have any additional questions in regards to this formulation, please do not hesitate to contact me at 901-432-5118 or at bill.washburn@arystalifescience.com.

Sincerely,

Bill Washburn Regulatory Manager

j )',

Arysta LileSc1ence North America Corporation
15401 Weston Parkway. Suite 150. Cary. NC USA 27513 Telephone: (+ 1) 919-678-4900 Fax: (+ 1) 919-678-2194 www.arystalifescience.com > >


### ,

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### " "

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# I
ysta LifeScience

:ebruary 6, 2007

Ms. Linda Propst Document Processing Desk Product Reregistration Branch/SRRD Office of Pesticide Programs

- 7508P U.S. Environmental Protection Agency One Potomac Yard (South Building), Room S-4400 2777 S. Crystal Drive Arlington, VA 

### 22202

Subject: Thidiazuron-Diuron EC EPA 

### Reg. No. 66330-333



## Response to Agency Letter Dated January 25, 

## 2007

Dear Ms. Propst:

Per your instruction in the letter referenced above, I am resubmitting for your review the following documents:

• 2 Copies

- Confidential Statement of Formula

- Basic Formulation

• 2 Copies

- Confidential Statement of Formula

- Alternate Formulation

• One Copy

- Revised Formulator's Exemption Statement

• 5 Copies

- Revised labeling to reflect change in ownership.

Should you find that you require any additional information to support the reregistration of this product, please do not hesitate to give me a call at 

### 901-432-5118 or e-mail me at bill.washburn@arystalifescience.com.

Sincerely,

Bill Washburn Regulatory Affairs Manager

Arysta LifeScience North America Corporation
15401 Weston Parkway, Suite 150, Cary, NC USA 27513 Telephone: (+1) 919-678-4900 Fax: (+1) 919-678-2194 www.arystalifescience.com

### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, D.C. 20460



### MICRO-FLO COMPANY LLC 

## 530 OAK COURT DRNE MEMPHIS, TN 38117- July 

## 7,2006

Report of Analysis for Compliance with PR Notice 86-5 OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUBSTANCES



### Thank you for your submittal of 03-JUL-06. Our staff has completed a preliminary analysis of the material. The results are provided as follows:

Your submittal was found to be in full compliance with the standards for submission of data contained in PR Notice 86-5. A copy of your bibliography is enclosed, annotated with Master Record ID's (MRIDs) assigned to each document submitted. Please use these numbers in all future references to these documents. Thank you for your cooperation. If you have any questions concerning this data submission, please raise them with the cognizant Product Manager, to whom the data have been released.

# MICRO.·J,

.... 

# FLO**1llEPl.iNrHill1HAND~** 

# COMPANY

June 30, 2006

Document Processing Desk (DCI/SRRD) Ms. Karen Jones, Chemical Review Manager Product Reregistration Branch Special Review and Reregistration Division

- 7504P Office of Pesticide Programs U.S. Environmental Protection Agency One Potomac Yard (South Building) 2777 S. Crystal Drive Arlington, VA 22202

Dear Ms. Jones



### Subject: Thidiazuron·Diuron EC EPA Reg. No. 51036-429 Data Call·ln 8·Month Response

Please find enclosed Micro Flo's 8-Month Response to the Product Specific Data Call-In for products containing the active ingredient diuron. The following materials are included in this submission:

1.) Application for Registration

2.) Data Matrix

- Agency and Public Copies

3.) Requirements Status and Registrant's Response

- REVISED



### 4.) Data Waiver Request

5.) Five (5) copies of Draft labeling

One Highlighted Copy and Four (4) Clean Copies

p.o. 

### 80x 

### 772099 • Memphis, TN 

### 38117-2099 • Office: 901-432-5000 • 

### Fox: 901-432-5100 

### 468773.00

### Ms. Karen Jones Thidiazuron-Diuron EC June 30, 2006 page 2

Also submitted in support of this application are three copies of the following data, which are enclosed:



## 1.) PhYSical Properties of 

## Thidiazuron-Diuron EC, EPA OPPTS Guideline Reference Number 830.6302 and 830.6304, 9 pages

Laboratory Project ID: MI-0601 MRID 

### No. 46877301



## 2.) Storage Stability of 

## Thidiazuron-Diuron EC (C) with Corrosion Characteristics, EPA OPPTS Guideline Reference Number 830.6317 and 830.6320, 10 pages

Laboratory Project ID: MI-0406 MRID 

### No. 46877302



## 3.) Thidiazuron-Diuron EC: Acute Oral Toxicity Up and Down Procedure in Rats, EPA OPPTS Guideline Reference No. 870.1100 (2002), 14 pages.

Laboratory Study No. 19086 MRID 

### No. 46877303



## 4.) Thidiazuron-Diuron EC: Acute Dermal Toxicity Study in Rats

- Limit Test, EPA OPPTS Guideline Reference No. 870.1200 (1998),14 pages

Laboratory Study No. 19087 MRID 

### No. 46877304



## 5.) Thidiazuron-Diuron EC: Acute Inhalation Toxicity Study in Rats -LCs o , EPA OPPTS Guideline Reference No. 870.1300 (1998), 30 pages

Laboratory Study No. 19088 MRID 

### No. _46_8_7_73_0_5

__ 

## 6.) Thidiazuron-Diuron EC: Primary Eye Irritation Study in Rabbits, EPA Guideline Reference No. 870.2400 (1998), 17 pages

Laboratory Study No. 19089 MR 46877306 

### IDNo.

____ _ 

## 7.) Thidiazuron-Diuron EC: Primary Skin Irritation Study in Rabb'ls, E"A Guideline Reference 870.2500 (1998),15 pages

Laboratory Study No. 19090 MRID 

### No. 48877307



# --

### Ms. Karen Jones Thidiazuron-Diuron EC June 30, 2006 page 3



## 8.) Thidiazuron-Diuron EC: Dermal Sensitization Study in Guinea 

## Pigs (Beuhler), EPA Guideline Reference No. 870.2600 (2003), 22 pages

Laboratory Study No. 19091 MRID No. 46877308



### If you 

## have any questions with respect to this submission please do not hesitate to contact the undersigned at 901-432-5118.

Sincerely,

# 2~~C/o~ Bill Washburn Regulatory Affairs ManagerUNITEDSTATESENVIRONMENTALPROTECTIONAGENCYFormApprovedOMSNo.2070"0060401MStreet,S.w.WASHINGTON,D.C.20460PaperworkReductionActNotice:"[teepublicrepc.1:n'ijbUrdENlfortrllScollectionofinformationisestimatedtoaverage0.25hoursperresponseforregistrationactivitiesand0.25hoursperresponseforreregistrationandspeciatreviewactivi!ies,Jnctudingliri1ebrinstructionsandcomptetingthenecessaryforms.Sendcommentsregardingtheburdenestimateoranyotheraspectofthiscollectionofinformation,includingsuggestions.forreducingOPPEInformationManagementDivision(2137),U.S.EnvironmentalProtectionAgency,401MStreet,S.W.,Washington,DC20460.Donotsendtheformtothisaddress:- 'DATAMATRIXDateJune29,2006EPAReg.No.lFileSymbol51036-429IPagetof2Applicant's/Registrant'sName&Addri;:!ss:C • •• - :ProductMicroFloCompanyLLC,P,O.BOk1'7:20:19,Memphis,TN38117Thidiazuron-DiuronEClngredient{s):Thidiazuron,CASReg.andDluron,CASReg.GuidelineReferenceNumberGuidelineStudyNameMRIDNumberSubmitterStatusNote830.1550ProductIdentityandComposition46236402MicroFloCompanyLLCOwn46236404830.t600DescriptionoftheMaterialsUsedtoProduce46236402MicroFloCompanyLLCOwntheProduct46236404830.1650DescriptionoftheManufacturingProcess46236402MicroFloCompanyLLCOwn46236404830.1670DiscussionofFonnationofImpurities46236402MicroFloCompanyLLCOwn46236404830.1750CertifiedLimits46236402MicroFloCompanyLLCOwn46236404830.1800EnforcementAnalyticalMethod46236402MicroFloCompanyLLCOwn46236404830.6302ColorMicroFloCompanyLLCOwnSubmitted06130/06830.6303PhysicalState46236401MicroFloCompanyLLCOwn46236403830.6304OdorMicroFloCompanyLLCOwnSubmitted06{30{06830.6314Oxidation/Reduction:ChemicalCompatibility46236401MicroFloCompanyLLCOwn46236403830.6315Flammability46236401MicroFloCompanyLLCOwn46236403830.6316Explodability830.6317StorageStabilityMicroFloCompanyLLCOwnSubmitted06130/06830.6319MiscibilityMicroFloCompanLLCWaiverrequested830.6320CorrosionCharacteristicsMicroFloCompanyLLCOwnSubmitted06/30/06830.6321DielectricBreakdownVoltageMicroFloCompanyLLCWaiverrequested830.7000pH46236401MicroFloCompanyLLCOwn46236403830.7100Viscosity46236401MicroFloCompanyLLCOwn______________SignatureNameandTitle:BillWashburn,RegulatoryAffairsManagerDateJune30,2006EPAForm857d·35t9.97)Eleol,onlcandPaperversionsavailable.Sub",1onlyPaperVerslOfl.AgenoyInternalUseCopy-UNITEDSTATESENVIRONMENTALPROTECTIONAGENCYFormApprol,'edOMBNo.2070-0060oI401MStreet,S.W.WASHINGTON,D.C.20460nActNotice:.T.'l::lpublicrepcr:ii-lgburger:!for'lhisCOllectionofinformationisestimatedtoaverage0.25hoursperresponseforregistrationacti"ilIesand0.25hoursperI-'alreviewactivtttes.)ncluding!ime,for,re;;'dih!ftheinstructionsandcomn1o>linnth<>f""""C:"nn(,rlm."""I",,,,n,,,rlinn....-.........._-_.-_.._..._-------,.-._.....,...----------,--..._.-------------.---.-.,-.-...---_....-...,_S.IOfreaucmg1I;.eI:!"urder.:to:D[":"ec!or,DPPEInformationManagementDivision(2137).U.S.Enl,'ironmenlalProtectionAgency,401MStreet,S.W_,\ntothis-DATAMATRIX.collectionDC20460.JUne29,2006EPAReg.Symbol. ,......,icant's/Registrant'sName&Addless:" , '..-'."IMicroFloCompanyLLC,p,O,Bfr.<-7-T2W9,Mempnis,TN38117Ingredient(s):Thidiazuron,CASReg.51707*55.2,andDiuron,CASReg.330·54*1O.lU./.lUU870.11870.870.870,870,ISkin:yNameelativeD1Tax''tatiorIMRIDI46236401ProductnECIINote- - ------'"IMicroFloCompanyLLC!Own-""IMicro!MicroMicroMicroMicroMicroCo.Co..CBillWashburn,RegulatoryAffairsManagerd06/30106d06/30/06d06/30/06June30,2006-oUNITEDSTATESENVIRONMENTALPROTECTIONAGENCY401MStreet,S.W.FormApprovedOMSNo.2070·0060WASHINGTON,D.C.20460toaverage0.25hoursperresponseforregistrationactivitiesand0.25andcompletingthenecessaryforms.SendcommentsregardingtheburdenestimateoranyotheraspectofthiscOllection0"OPPEInformationManagementDivision(2137),U.S.EnvironmentalProtectionAgency,401MStreet,S.W.,Washington,DC20460.DATAMATRIXDateJune29,2006No.lFile51036-429Page1of2ProductFloCompanyLLC,P.O.Memphis,TN38117Ingre(!ient(s):Thidiazuron,CASReg.andDiuron,CASReg.330·54-1SignatureNameandTitle:BillWashburn,RegulatoryAffairsManagerDateJune30,2006EPAForm6570·35(9'S7)Ele(:lron;c<lfidiiaperVB!soonsa""ilable.Submii";;niyPaperAgencyInlernalUseCopy."..oroeUNITEDSTATESENVIRONMENTALPROTECTIONAGENCY401MStreet,S.W.WASHINGTON,D.C.20460thenecessaryforms.ManagementDivision(2137).U.S.DATAMATRIXFormApprovedOMBNo.2070·0060perresponseburdenestimateoranyotheraspectofthiscOllectionProtectionAgency,401MStreet,S.W.,Washington,DC20460.DateJune29,2006EPAReg.NoJFileSymbolPage2of2ProductFloCompanyLLC,P.O.Box772099,Memphis,TN38117Ingredient(s):Thidiazuron.CASReg.andDiuron,CASReg.330-54·1SignatureNameandTitle:DateBillWashburn,RegulatoryAffairsManagerJune30,2006EPAFo.m8SiO:3519-971Eleclronicaiid?ape;-v..-sionsavailable.Subrriiioiii;;-Paperveml",,_AgencyInternalUseCopyPage1of4UnitedStatesEnvironmentalProtectionOMBApprova12070.0107AgencyWashingt<Jn,D.C.20460OMSApproval2070·0057H.EQU'HElVt1l!,!TSSTATUSANDREGISTRANT'SRESPONSE""tSTRUCTIONS:Pleasetypeor:;:'rintinink.PI('ai:"lreaec;::retul!::theattachedinstructionsandsupplytheinformationrequestedonthisform.seaddilionalsheel(s)ifnecessa'ry.-" ".CompanyNameandAddress" "2.Case#andName3.DateandTypeofDCIandNumber""MICRO-FLOCOMPANYLLC"""-0046oiuron28-0ct-200S..'.-"530OAKCOURTDRIVE"-PRODUCTSPECIFICMEMPHIS.TN3811710#PoCI-035S0S-24653EPAReg.No.51036-429Gl(ldeline5.StudyTitle'p6.UseRProgress7.Test8.Time9.Registrantequirement0PatternSubstanceFrameResponselimberTReports(Months)0C0l123ProductCh!)mi§tr)!D<!t<!Beguiremgnjl;!(J:;Q!]vention<!!Chemical)1O.1550ProductIdentityandcomposition(28)A,B,C,D,E,F,G,H,J,TGAl/MPfEP8bJ,K,L.M,N,010.1600Descriptionofmaterialsusedtoproducetheproduct(29)A,B,C,D,E,F,G,H,J,TGAJlMPfEPB"(0J,K,L,M,N,O1O.1620Descriptionofproductionprocess(30)A,B,C,D,E,F,G,H,J,TGAI8J,K,L.M,N,010.1650Descriptionofformulatlonprocess(31)A,B,C,0,E,F,G,H,J,MPfEP8("J,K,L,M,N,0)0.1670Discussionofformationofimpurities(32)A,B,C,D,E,F,G,H,I,TGAIfMPfEPB(jjJ,K,L,M,N,010.1700Preliminaryanalysis(33,34,35)A,B,C,0,E,F,G,H,J,TGAI8J,K,L,M,N,0;0.1750Certifiedlimits(36,37)A,B,C,0,E,F,G,H,I,TGAI/MP/EP8IpJ,K,L,M,N,O10,t800Enforcementanalyticalmethod(38)A,B,C,0,E,F,G,H,I,TGAlfMPfEP8foJ,K,L,M,N,010.6302Color(13)A,B,C,0,E,F,G,H,I.,TGAl/MPfEPB/pJ,K,L,M,N,O10.6303Physicalstate(16)A,B,C,0,E,F,G,H,I,TGAlfMP/EPBQ,J,K,L,M,N,01.CertificationIcertifytatthestatementsmadeonthisformandallattachmentsaretrue,accurte,andcomplete.Iacknowledgethatany11.Dater,,!jO/O{o10winglyfalseDrmisleadingstatementmaybepunishablebyle"imprisonmentorbothunderlaw"gnalureandTitleofCompany'sAuthorizedRepresentativet..lJ.ReQ.ulahnyf.JFfC./rfIfACJ1tJre/NameofCompanyCOm9RI'l'lLLG13.PhoneNumbertfOl'-132-511£3

# \ 

# \ 

# MICROst. .'. FLO

lHEl'li.17!lEAL1llANDI'IlJrKmi 

# COMPANY

June 30, 2006

Document Pr essing Desk (DCI/SRRD) 

### Ms. Kar ones, Chemical Review Manager Pro uct Reregistration Branch Special Review and Reregistration Division

- 7504P Office of Pesticide Programs U.S. Environmental Protection Agency One Potomac Yard (South Building) 2777 S. Crystal Drive Arlington, VA 22202

Dear Ms. Jones



### Subject: Thidiazuron-Diuron EC EPA Reg. No. 51036-429 Data Call-In 8-Month Response

Please find enclosed Micro Flo's 8-Month Response to the Product Specific Data Call-In for products containing the active ingredient diuron. The following materials are included in this submission:

1.) Application for Registration

2.) Data Matrix

- Agency and Public Copies

3.) Requirements Status and Registrant's Response

- REVISED



### 4.) Data Waiver Request

5.) Five (5) copies of Draft labeling

One Highlighted Copy and Four (4) Clean Copies

RO Box 772099 • Memphis, TN 38117-2099 • Office: 901-432-5000

.. Fox: 901-432-5100 

### 488773-00

## Ms. Karen Jones Thidiazuron-Diuron EC June 30, 2006 page 2

Also submitted in support of this application are three copies of the following data, which are enclosed:



## 1.) Physical Properties of 

## Thidiazuron-Diuron EC, EPA OPPTS Guideline Reference Number 830.6302 and 830.6304, 9 pages

Laboratory Project ID: MI-0601 MRID No. 46877301



## 2.) Storage Stability of 

## Thidiazuron-Diuron EC (C) with Corrosion Characterisiics, EPA OPPTS Guideline Reference Number 830.6317 and 830.6320, 10 pages

Laboratory Project ID: MI-0406 MRID No. 46677302



## 3.) Thidiazuron-Diuron EC: Acute Oral Toxicity Up and Down Procedure in Rats, EPA OPPTS Guideline Reference No. 870.1100 (2002), 14 pages.

Laboratory Study No. 19086 MRID No. 46877303



## 4.) Thidiazuron-Diuron EC: Acute Dermal ToxiCity Study in Rats

- Limit Test, EPA OPPTS Guideline Reference No. 870.1200 (1998), 14 pages

Laboratory Study No. 19087 MRID No. 46877304



## 5.) Thidiazuron-Diuron EC: Acute Inhalation Toxicity Study in Rats-LC so , EPA OPPTS Guideline Reference No. 870.1300 (1998), 30 pages

Laboratory Study No. 19088 MRID No. 48877305



## 6.) Thidiazuron-Diuron EC: Primary Eye Irritation Study in Rabbits, EPA Guideline Reference No. 870.2400 (1998),17 pages

Laboratory Study No. 19089 MRID No. 46877306



## 7.) Thidiazuron-Diuron EC: Primary Skin Irritation Study in Rabb·'{s, 

## E"A Guideline Reference 870.2500 (1998), 15 pages

Laboratory Study No. 19090 MRID No. 4687730_7

__

## Ms. Karen Jones Thidiazuron-Diuron EC June 30, 2006 page 3



## 8.) Thidiazuron-Diuron EC: Dermal Sensitization Study in Guinea Pigs (Beuhler), EPA Guideline Reference No. 870.2600 (2003), 22 pages

Laboratory Study No. 19091 MRID No. _4_68_7_73_0_8

__



### If you have any questions with respect to this submission please do not hesitate to contact the undersigned at 901-432-5118.

Sincerely,

# ~~Lu~~ BiliWashbum Regulatory Affairs Manager

## DATA PACKAGE BEAN SHEET

Date: 06·Feb·2007 Page t of 3



### * * 

## * Registration Information 

## * * *

Registration: PDCI-03SS05-24653 

### DP 

## #: (336474)

Short Name:**~i~_r_~I1** __**~I:l<?LL!.2'~?~Q~t_~** 

## __ . __**~** 

## _____________**~_.____** 

## ___ _____________ _ ____ "

_________ _ Company: 51036 -BASF SPARKS llC

Risk Manager: AM 81

- Unda

- Propst

- (703) 308-8165 Room# PYt S-9641

Risk Manager Reviewer:

_______________________ _ Type of Data Call in:**CP~m~d~"'~t~S~p~"~if~i''_** ____ _ Ingredients: 035505, Dimon

Guidelines:**oS~"=pa~g~'~3'_** ________________________ _



## * * * Data Package Information 

## * 

## * *

Expedite: 

## 0 Yes. No Date Sent: 06-Feb-2007 Due Back:

____ _

DP Ingredient: 035505, Diuron

DP Title: Review acute lox data

CSF Included: 

## 0 Yes. No label Included: () Yes. No Parent DP #:

Assigned To Da1e In Date Out

Organization:**,S~R~R~D~/~P~R~B'_** _____ _ last Possible Science Due Date:

Team Name:

__________ _ Science Due Date:

Reviewer Name:

__________ _ Sub Data Package Due Date:

Contractor Name:

__________ _



## * * * Studies Sent for Review 

## * * *

Printed on Page 2



### * 

## * * Additional Data Package for this Decision 

## * * *

No Additional Data Packages



### * 

## * * Data Package Instructions 

## * * 

## *

Review acute tox data 66330-33 (formerly 51036-429)

# , Page 2
DP#-: (336474) ••• Studies Sen110r Review'" Decision#-: (0)

Moore, G. (2006) Acute Oral Toxicity Up

### '~:lo~'~~~;';~:~'3~"'~~:~~~;h" Thidiazuron-Diuron EC. Project Number:

. study prepared by Product Satety Laboratories. 14 p. 46877304 Moore, G. (2006) Acute Dermal Toxicity Study in Rats

- Limit Test: Thidiazuron-Diuron 870. t200lAcute dermal10xicity EC. Project Number: 19087, P322. Unpublished study prepared by Product Safety Laboratories. 14 p. 46877305 Moore, G. (2006) Acute Inhalation Toxicity Study in Rats

- LCSO: Thidiazuron-Diuron 870.1300fAcute inhalation toxicity EC. Project Number: 19088, P330. Unpublished study prepared by Product Safety Laboratories. 30 p. 46877306 Moore, G. (2006) Primary Eye Irritation Study in Rabbits: Thidiazuron-Diuron EC. 870.2400iAcute eye irritation Project Number: 19089, P324. Unpublished study prepared by Product Safety Labora1ories. 17 p. '< 46877307 Moore, G. (2006) Primary Skin Irritation Study in Rabbits: Thidiazuron·Diuron EC. 870.2S00lAcute dermal irritation Project Number: 19090, P326. Unpublished study prepared by Product Safety Laboratories. 15 p. 46877308 Moore, G. (2006) Dermal Sensitization Study in Guinea Pigs (Buehler Method): 870.2600fSkin sensitization Thidiazuron-Diuron EC. Project Number: 19091, P328. Unpublished study prepared by Product Safety Laboratories. 22 p.Ptease read Instruciions on reverse befOffi npleting form. Form Approved, OMB No. 2070-0060, Approval
ex ires 05-31-98



# - EPA United States 

### 0 Registration opp Identifier Number 

# 0 Environmental Protection Agency 

### 0 Amendment Washington, DC 20460 

## 0 Other:
Application for Pesticide

- Section I

1. Company/Product Number 

# 2.
EPA Product Manager 3. Proposed Classification 66330-333 

### J. MILLER 4. CompanY/PlOduct (Name) PM. ONone 

# o Restricted THIDIAZURON-DiURON EC 

### 23 5. Name and Address of Applicant (tnclude ZIP Code) 6. Expedited Review. In accordance with FIFRA Section 3{c){3)

Arysta LifeScience North America Corporation (b){l), my product is similar or identical in composition and labeling to: 15401 Weston Parkway, Suite 150 EPA Reg. No. Cary, NC 27513 Product Name 

# D Check if this is a new address

Section -II 

# o Amendment

- Explain below. D Final printed labels in lesponse to Agency lelter daled (Sl Resubmission in response to Agency letter dated j/25/07 

# o "Me Too" Application 

# o Notification

- Explain below. 

# o Other

- Explain below Explanation: USe additional page(s) if necessary. (For Section I and Section 11.)

Resubmission in response to Agency letter dated 

### 1/25/07. Submission of Confidential Statements of Formula, revised labeling to reflect change in ownership and a revised Formulator's Exemption Statement for the active ingredient Diuron.



### Section -III

1. Material This Product Will Be Packa ed In: Child-Resistant Packaging Unit Packaging Water Soluble Packaging 2. Type of Containel
DYes' DYes 

# o Yes 

# o Metal 

## IS] No 

## IS] No 

## IS] No (Sl PlasUc If "Yes" No. per If "Yes" No. per 

# o Glass 

### *Certification must Unit Packaging wgt. container Package wgt. container 

# o Paper 

### be submitted 

# o Othel (Specify) 3. localion ot Net Contents Information 4. Size(s) Retail Container 5. location of label Directions (Sllabel D Container (Sl On label 2.5 gal, 15 gal, 30 gal, 55 gal and bulk 

# o On labeling accompanying product 6. Manner in Which label is Affixed to Producl 

# o lilhoglaph 

# o Other 

### [8] Paper glued 

# o Slenciled

Section -IV

1. Contact Poinl (Comp/ete items directly below for identification of individual to be contacted, if necessary, to process this application) Name Title 

# ,! Telephone NC;(Include Area

BILL WASHBURN REGULATORY AFFAIRS MANAGER**:\)'~0lje)** } 

## ,>

:

.. : 901-432-5118

Certification 

# .. , , , 6. Date Application



# . '**Repiliv~d** I certify that the statements I have made on this form and all attachmenls thereto are true, accurate and complete. I acknowledge that any knowingly false or misleading stalement may be punishable by fine or imprisonment or both '**J~t~lnped)** under applicable law.**.~** 

### ,

# 2'\6~

# L:o-o~ 3. Tille 

### ,'" " 

## . REGULATORY AFFAIRS MANAGER**.~_~** 4'
4. Typed Name 5. Date 

### ., 

# . . BILL WASHBURN 

### February 6, 

### 2007 ., 

### ,



## . . .


# - ..

. - EPA Form 8570 1 (Rev. 8 94) Previous editions are obsolete White EPA File Copy (onglnal) Yellow Applicant CoptF orm approve

. 

## - d OMB NO 2070 0060 A pprova IE 1 3(}'93 xplres

- United States Environmental Protection Agency 

## ft Washington, D.C. 20460



### - - 

# o EPA Formulator's Exemption Statement ,

- 

### (40 CFR 152_85)

- . 

### ; Applican1's Name and Address EPA File SymbolfRegistration Number

Arysta LifeScience North America Corporation 66330-333 15401 Weston parkway, Suite 150 " 

# ..**-.~---** Product Name Cary, NC 27513 THIDIAZURON-DiURON EC

Date of Confidential Sialement of Fonnu,a'{EPA Form 8570-4) 02105107

As an authorized representative of the applicant for registration of the product identified above, I here certify that:
(1) This product contains the following active ingredient(s): Thidiazuron and Diuron

(2) Of these, each active ingredient listed in paragraph (4) is present solely as Ihe result of the use of that active ingredient in the manufacturing, formulation or repackaging of another product which contains that active ingredient, which is registered under FIFRA Section 3, is purchased by us from another producer, and is labeled for alleast each use for which my product is proposed 

### 10 be labeled.

(3) Indicate by checking (A) or (8) below which paragraph applies: 

# o (A) An accurate Confidential Statement of Formula 

### (EPA Form 8570-4) for Ihe above identified product is attached to this statement. That formula slatement indicates, by company name, registralion number, and product name, the source of the active ingredient(s) listed in paragraph (1). OR 

# [gJ (8) The Confidential Statement of Formula 

### (eSF) (EPA Form 8570-4) referenced above and on file wilh the EPA is complete, current, and accurate and contains the informalion required on the current CSF.

(4) The following active ingredients in this product qualify for the formulator's exemption.

Source

Active Ingredient Product Name Registration Number

Diuron



# Sb:,**WC<ilLJhLc~** Name and Title D,te Bill Washburn 02105107 Regulatory Affairs Manager

EPA Form 8570-27 (Rev. 7·91) White

- EPA copy Yellow· Applicant copy

### Certified Mail Provides: • A mailing receipt (cSJlMulj)**~om:** aunr 'oosc**w,~** Sd • A unique identifier for your mailpiece • A record of delivery kepI by the Postal SeNiee fortwa years /mp'ortant Reminders:

• Certified Mall may ONLY be combined w1\h First-Class Mailo or Priority Mai"'ll.

• Certffied MaillS nol available for any class of Inlernational mail.

c NO INSURANCE COVERAGE IS PROVIOED with Certified Mall. For

valuables, please consider Insured or Registered Mall.

a For an additional fee, a Raturn Reoaipfmay be requested fo provide proof of

delivery. To obtain Return Receipt OOIVIC€!, pfease complete and attach a Return Reoeipl (PS FOffi1 3811) fo the articla and add applicable pas/age fo cover Ihe fee, Endorse mailpiece 'Holum Receipt Requested". To receive a fee waiver for
a dvplic!lle relurn receipt, a USPS® postmark on your Certified Mail racelplls reqUired.

• For an addllional fee, delivery may be restricted to file addressee or

addressee's authorized agenf. Advise fhe clerk or mark the mallplece with the endorsement 'RestricfedDelivery'.

• II a poslmark on the Certified Mail receipt is desired, please present fhe article al the post oHice for postmarking. If a postmark on the Certilied Mall receipl is not needed. detach and allix label with postage and mall. 

### IMPORTANT: Salle Illis receipt and present it wilen making an inquiry. Internet access tn delivery intormalion is nol avaiiable on mali addtessed to APOs and FPOs.

### Micro Flo Company LLC P.O. Box 772099 Memphis, TN 38117

PRODUCT NAME: Thidiazuron-Diuron EC EPA File Symbol: 51036-429

DATA WAIVER REQUEST

OPPTS Guideline 830.6319 The purpose of this test is to obtain information and determine the miscibility for a product. This test is intended to determine whether a pesticide solution is suitable for application after dilution with oil or other nonpolar solvents, where applicable, instead of water.

Thidiazuron-Diuron EC is made up with emulsifiers that work only when diluted in water. The label for this product is written to limit the application of this product in water and/or tank mixes with water.



## For this reason we are requesting a waiver of this data requirement.

Reference:



## Product Properties Test Guidelines: OPPTS 830.1000, Background for Product Properties Test Guidelines; EPA 712-C-96-310, August 1996

MFC Waiver 51036·432 (830.6319) 

### 1

### Micro Flo Company LLC P.O. Box 772099 Memphis, TN 38117

PRODUCT NAME: Thidiazuron-Diuron EC EPA File Symbol: 51036-429

DATA WAIVER REQUEST

OPPTS Guideline 830.6319 The purpose of this test is to obtain information and determine the miscibility for a product. This test is intended to determine whether a pesticide solution is suitable for application after dilution with oil or other nonpolar solvents, where applicable, instead of water.

Thidiazuron-Diuron EC is made up with emulsifiers that work only when diluted in water. The label for this product is written to limit the application of 

### this product in water and/or tank mixes with water.



## For this reason we are requesting a waiver of this data requirement

Reference:



## Product Properties Test Guidelines: OPPTS 830.1000, Background for Product Properties Test Guidelines; EPA 712-C-96-310, August 1996

MFC Waiver 51036·432 (830.6319) 

## 1

### Micro Flo Company LLC P.O. Box 772099 Memphis, TN 38117

PRODUCT NAME: 

### Thidiazuron-Diuron 

## EC EPA File Symbol: 

### 51036-429

DATA WAIVER REQUEST

OPPTS Guideline 830.6321 

### The purpose of this test is to determine the potential for hazard when the pesticide product is used on or in the vicinity of electrical equipment and electrical conduits. Data is required when the end-use product is a nonconductant liquid and is to be used around electrical equipment.

Thidiazuron-Diuron 

## EC is formulated with nonconductant solvents, but it is not designed to be used around electrical equipment or electrical conduits. Thidiazuron-Diuron 

## EC is a cotton harvest aide and is not labeled for use around electrical equipment of electrical conduits.

For this reason we are requesting a waiver of this data requirement.

Reference:



### Product **Properties Test**  **Guidelines: OPPTS**  **830.1000, Background**  **for Product**  **Properties Test**  **Guidelines;** EPA 

### 712-C-96-310, August 1996

MFC 

### Waiver 51 036-432 (830.6321) 

## 1

### Micro Flo Company LLC P.O. Box 772099 Memphis, TN 38117

PRODUCT NAME: Thidiazuron-Diuron EC EPA File Symbol: 51036-429

DATA WAIVER REQUEST

OPPTS Guideline 830.6321 The purpose of this test is to determine the potential for hazard when the pesticide product is used on or in the vicinity of electrical equipment and electrical conduits. Data is required when the end-use product is a nonconductant liquid and is to be used around electrical equipment.

Thidiazuron-Diuron EC is formutated with nonconductant solvents, but it is not designed to be used around electrical equipment or electrical conduits. Thidiazuron-Diuron EC is a cotton harvest aide and is not labeled for use around electrical equipment of electrical conduits.



## For this reason we are requesting a waiver of this data requirement.

Reference:



## Product Properties Test Guidelines: OPPTS 830.1000, Background for Product Properties Test Guidelines; EPA 712-C-96-310, August 1996

MFC Waiver 51036·432 (830.6321) 

## 1

### Date: 

# 0:;;>-[ 

# 111 (J

# ~ OPPIN
PDCI RESPONSES IN PROCESSING FORM

CASE NUMBER:

PRODUCT NUMBER(s):

Circle appropriate submission/response code:



### SUBMISSION TYPE:

# ~ay**Re~** 1 

### tooth Response



### RESPONSE CODE: (For 90-day responses)

(For 

### 8 month responses) 10

M 

### Incomplete Response 50

- Voluntary Cancellation 

### 94

- NOITS

10

M 

### Incomplete Response 

### 11

- Data Deficiency 50

M 

### Voluntary Cancellation 

### 94

- NOITS

# MICRO "'FLO

THEI'IANrlliAmiAhul'ImB:i1JN 

# COMPANY

February 6, 2006

Ms. Karen Jones, Chemical Review Manager Product Reregistration Branch Special Review and Reregistration Branch 7508W Office of Pesticide Programs Crystal Mall 2, Room 266A 180 I South Bell Street Arlington, VA 22202



### Subject: Thidiazuron-Diuron E. 

## C EPA Reg. No. 51036-429

Diuron Data Call-In

- 90-Day Response

Dear Ms. Jones:

Per the requirements of the Diuron Data Call-In dated October 28,2005, please find the fonowing documents enclosed in support of the subject product:

• Data CaIl-In Response

• Requirement's Status and Registrant's Response

• Data Waiver Request

- OPPTS Guideline 830.6319

• Data Waiver Request

- OPPTS Guideline 830.6321

The product specific data that has been cited in the Requirement's Status and Registrant's and revised labeling response wiII be submitted in the time frame allowed in the Data CaIl-In. Should you have any questions in regards to this submission, please do not hesitate to contact me at 901-432-5118 or bilI.washburn@microflocompany.com.

Sincerely, /)

# ,j~~rJ/j~ Bill Washburn Regulatory Affairs Manager

### ~t 

# . 

# :t/1o/bt

- "------P.cxtrox 772099 It 

### Memphis, TN 38117-2099 It 

### Office: 901-432-5000 It Fox:

### 901-432~q**~,OO** " > > , ,



### , "



### , 

# . "

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### , , , ,
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### "



### , "Page1of1UnitedStatesEnvironmentalProtectionOMBApprova12070-0t07AgencyWashington,D.C.20460OMBApproval2070-0057DATACALL-INRESPONSEINSTRUCTIONS:Pleasetypeorprintinink.Pleasereadcarefullytheattachedinstructionsandsupplytheinformationrequestedonthisform.Useadditionalsheet(s)ifnecessary.1.CompanyNameandAddress2.Case#andName3.DateandTypeofDCIandNumberMICRO-FLOCOMPANYLLC0046Diuron28-0ct-2005530OAKCOURTDRIVEChemical#andName035505PRODUCTSPECIFICMEMPHIS,TN38117Diuron10#PDCI-035505-246534.EPA5.Iwishto6.GenericData7.ProductSpecificDataProductcancelthisRegistrationproductregis-6a.IamclaimingaGeneric6b.IagreetosatisfyGeneric7a.MyproductisanMUPand7b.MyproductisanEUPandtrationYolun-DataExemptionbecauseIDatarequiremenlsasindicatedIagreetosatisfytheMUPIagreetosatisfytheEUP"tarilyobtaintheactiveingredientontheattachedformentitledrequirementsontheattachedrequirementsontheattachedfromthesourceEPAregis-"RequirementsStatusandformentitled"ReqUirementsformentitled"Requirementstrationnumberlistedbelow.Registrant'sResponse."StatusandRegistrant'sStatusandRegistrant'sResponse."Response."51036-429NANAX.,,,,,,.,8.CertificationIcertifythatthestatementsmadeonthisformandallattachmentsaretrue,accurate,andcomplete.Iacknowledgethatany9.Date1/2'I/MknowinglyfalsemaybepunishablebYh!mprisonmentorbothunderapplicablelaw.,SignatureandTtlle:ofS;OLtlpaf1:l'sAuthorizedRepresentativeUf£hl':JfJf!k/lf5IlAcnoqeffO.Nameof_••I'r\lclZO'LOCtlMPAN'iLLe11.PhoneNumberfDr'l3.1·5;;8Page1of4UnitedStatesEnvironmentalProtectionOMBApprova!2070-0t07AgencyWashington,D.C.20460OMBApprova!2070-0057REQUIREMENTSSTATUSANDREGISTRANT'SRESPONSEINSTRUCTIONS:Pleasetypeorprintinink,Pleasereadcarefullytheattachedins!ructionsandsupplytheinformationrequestedonthis10rm,Useadditionalshee!(s)ifnecessary.1.CompanyNameandAddress2.Case#andName3.DateandTypeofDCIandNumberMICRO-FLOCOMPANYLLC0046Diuron28-0ct-2005530OAKCOURTDRIVEPRODUCTSPECIFICMEMPHIS,TN3811710#PDCI-035505-24653EPAReg.No.51036-4294.Guideline5.Study Titlep6.Use7.Test8.Time9.RegistrantRProgressRequirement0PatternSubstanceFrameResponseNumberTReports(Months)0C0L123eCQgY!<iQilt"B!l!gYilll:rn!l!!ltli(CQ[]y!U!lis;![!a!Chemica!)830.1550ProductIdenlityandcomposilion(28)A,B,C,0,E,F,G,H,I,TGAI/MP/EP8i:,J,K,L,M,N,0830.1600Descriptionofmaterialsusedtoproducetheproduct(29)A,B,C,0,E,F,G,H,I,TGAI/MP/EP8roJ,K,L,M,N,0830.1620Descriptionofproductionprocess(30)A,B,C,0,E,F,G,H,I,TGAI8J,K,L,M,N,0830.1650Descriptionofformulationprocess(31)A.B,C,0,E,F,G,H,I,MP/EP8G,J,K,L,M,N,0830.1670Discussionofformationof(32)A,B,C,0,E,F,G,H,I,TGAI/MP/EP8iDJ,K,L,M,N,0830.1700Preliminaryanalysis(33,34,35)A,B,C,0,E,F,G,H,I,TGAI8J,K,L,M,N,0830.1750Certifiedlimits(36,37)A,B,C,0,E,F,G,H,I,TGAI/MP/EP/pJ,K,L,M,N,0830.1800EnforcementanalyUcalmethod(38)A,B,C,0,E,F,G,H,I.TGAIIMP/EP8{pJ,K,L,M,N,0830.6302Color(13)A,B,C,0,E,F,G,H,I,TGAI/MP/EP8(p:lPhysical:J,K,L,M,N,0830.6203:'(16)A,B,C,0,E,F,G,H,I,TGAI/MP/EP86.>..c _J,K,L,M,N,0-- -10.CertificationGertify':at<ihesta!ementsmadeonthisformandaUattachmentsaretrue,acurte,ndmplete.Iacknowledgethatany11.Dateknowinglyfalsemaybepunishablebyle"imprisonmentorbothunderlaw'/fA1/20/010SignatureandTitleRepresentativethReQ"falvlL{f}(1c,tf.(CJ1t:9t>/12.NameofCompanyrLOtomDAN'!LLC,13.PhoneNumberq{)/.4.12'5J1BPage2of4UnitedStatesEnvironmentalProtectionOMBApproval2070-0t07AgencyWashington,D.C.20460OMBApproval2070-0057REQUIREMENTSSTATUSANDREGISTRANT'SRESPONSEINSTRUCTIONS:Pleasetypeorprintinink.Pleasereadcarefullytheallachedinstructionsandsupptytheinformationrequestedonthisform.Useadditionalsheel(s)ifnecessary.1.CompanyNameandAddress2.Case#andName3.DateandTypeofDCIandNumberMICRO-FLOCOMPANYllC0046Diuron28-0ct-2005530OAKCOURTDRIVEPRODUCTSPECIFICMEMPHIS,TN3811710#PDCI-035505-24653EPAReg.No.51036-4294.Guideline5.StudyTillep6.Use7.Test8.Time9.RegistrantRProgressRequirement0ReportsPallernSubstanceFrameResponseNumberT(Monlhs)0C0L1 23830.6304}(,Odor(17)A,S,C,0,E,F,G,H,I,TGAIIMP/EP8IJ,K,l,M,N,0830.6313Stabilitytosunlight,normalandelevated(5.6)A,S,C,0,E,F,G,H,I,TGAI8temperatures,metals,andmetalionsJ,K,l,M,N,0830.6314Oxidizingorreducingaction(7)A,S,C,0,E,F,G,H,I,MP/EP810J,K,l,M,N,0830.6315Flammability(8)A,S,C,0,E,F,G,H,I,MP/EP10J,K,l,M,N,0830.6316Explodabilily(9)A,S,C,0,E,F,G,H,I,J,K,l,M,N,0MP/EP8I830.6317'Storagestabilityofproduct(10)A,S,C,0,E,F,G,H,I,MP/EP84-J,K,l,M,N,0830.6319'Miscibility(12)A,S,C,0,E,F,G,H,I,MP/EP81J,K,l,M,N,O830.6320'Corrosioncharacteristics(14)A,S,C,0,E,F,G,H,I,MP/EP8ifJ,K,l,M,N,0830.6321\Oielectricbreakdownvoltage(15)A,S,C,0,E,F,G,H,I,J,K,l,M,N,0MP/EP87830.7000pHofwatersolutionsorsuspensions(3,4)A,S,C,0,E,F,G,H,I,TGAI/MP/EP8&>:hVtyisibJeJ,K,l,M,N,0830.7C50:A,S,C,D,E,F,G,H,I,TGAI/PAI8J,K,l,M,N,0""" """"""""""""Iv v_130i.tnitialtoindicatea'"io-informationonthispageDate(fulltextofcertificationisonpageone).Page3of4,UnitedStatesEnvironmentalProtectionOMBApprovat2070-0to7AgencyWashington,D.C. 20460OMBApprovat2070-0057REQUIREMENTSSTATUSANDREGISTRANT'SRESPONSEINSTRUCTtONS;Pteasetypeorprintinink.Pteasereadcarefuttytheattachedinstructionsandsupptytheinformationrequestedonthisform.Useadditionatsheet(s)ifnecessary.1.CompanyNameandAddress2.Case#andName3.DateandTypeofOCtandNumberCOMPANYLlC0046Diuron28-0ct-2005530OAKCOURTDRIVEPRODUCTSPECIFICMEMPHIS,TN3811710#PDCt·035505-24653EPAReg.No.51036-4294.Guidetine5.StudyTiltep6.Use7.Test8.Time9.RegistrantRProgressRequirement0ReportsPatternSubstanceFrameResponseNumberT(Months)0C0l123830.7100Viscosity(11)A,B,C,0,E,F,G,H,t,J,K,l,M,N,0MP/EP8(p830,7200Mettingpoint/mettingrange(18,19)A,B,C,0,E,F,G,H,t,TGAI8J,K,L,M,N,0830.7220Boitingpoint/boitingrange(20.21)A,B,C,0,E,F,G,H,I,TGAI8J,K,L,M,N,0830.7300Densitylretativedensity(22,23)A,B,C,0,E,F,G,H,I,TGAI/MP/EP8It>J,K,l,M,N,0830.7370Dissociationconstantinwater(39,40)A,B,C,0,E,F,G,H,I,J,K,l,M,N,0TGAIorPAt830.7550Partitioncoefficient(n-octanot/water),shakeflask(1)A,B,C,0,E,F,G,H,I,TGAIIPAI8methodJ,K,L,M,N,0830.7570Partitioncoefficient(n-octanotfwater),estimationby(2)A,B,C,0,E,F,G,H,I,TGAt/PAI8tiquidchromatographyJ,K,l,M,N,0830.7840Watersotubitity:Cotumnetutionmethod,shakeflask(24)A,B,C,0,E,F,G,H,I,TGAIorPAl8methodJ,K,l,M,N,0830.7860Watersotubitity,generatorcotumnmethod(25)A,B,C,0,E,F,G,H,I,TGAIorPAl8J,K,l,M,N,0830.7950Vaporpressure(26,27)A,B,C,0,E,F,G,H,I,TGAIorPAl8RequiOlments(ConventionatChemjcallJ,K,L,M,N,0...., , ,." "..".,".InWalloindicateacinformationonthispage80.;DateI//0(1)(futllexlofcertificationisonpageone).Page4of4UnitedStatesEnvironmentalProtectionOMBApprovat2070"0t07AgencyWashington,D.C.20460OMSApprovat2070-0057REQUIREMENTSSTATUSANDREGISTRANT'SRESPONSEINSTRUCTIONS:Pleasetypeorprinlinink.Pleasereadcarefullytheattachedinstructionsandsupply1heinformationrequestedonthisform.Useadditionalsheet(s)ifnecessary.1.CompanyNameandAddress2.Case#andName3.DateandTypeofDCIandNumberMICRO-FLOCOMPANYLLC0046Diuron28-0ct-2005530OAKCOURTDRIVEPRODUCTSPECIFICMEMPHIS,TN3811710#PDCI-035505-24653EPAReg.No.51036-4294.Guidelinep6.Use7.Test8.Time9.Registrant5.StudyTWeRProgressRequirement0ReportsPatternSubstanceFrameResponseNumberT(Months)0C0L123870.1100AcuteOralToxicity(49)A.B,C,0,E,F,G,H,I,TGAI,EP,diluteEP?8IJ,K,L,M,N,0870.1200Acutedermaltoxicity(41,42)A,B,C,0,E,F,G,H,I,TGAI,EP,diluteEP?8IJ,K,L,M,N,0870.1300Acuteinhalationtoxicity(48)A,B,C,0,E,F,G,H,I,TGAI&EP8IJ,K,L,M,N,0870.2400Acuteeyeirritation(43)A,B,C,0,E,F,G,H,I,J,K,L,M,N,0TGAI&EP8I870.2500Acutedermalirritation(44,45)A,B,C,0,E,F,G,H,I,TGAI&EP8IJ,K,L,M,N,0870.2600Skinsensitization(46,47)A,B,C,0,E,F,G,H,I,TGAI&EP8IJ,K,L,M,N,0iInitialtoindicatecertificationastoinformationonthispage6wDateiIzLjIOIi!I(fulltextofcertificationisonpageone).

# -----_

... 

## -- -

•



# ,



# .. ___ .. _________ SpHldl&JI\I------

I,

)

### DIT )N PRODUCT SPECIFIC DATA CALL-Il Please read instruC/ions on reverse before comp/elill:, ,o'rm Form Approved OMS No 2070·0060 Approval



### , ;



# - EPA United States 

# o Registration opp Identifier Number 

# 0 Environmental Protection Agency 

# o Amendment
i ,DC 20460 

### other:

Application for Pesticide

- Section I


### 1. 

## C I 3. 

### I 

# , 

# "

4. I**IIRn~** 

### EC

### ;~. 

## [3J None 

# o Reslricled 

### I

5. 

### ,ot 

# " I (tod,d, 

### ZIP Cod,; 

### 6. i In

, with FIFRA

MICRO FLO COMPANY LLC {b}{I}, my product is similar or identical in composition and labeling to: P.O. BOX 772099 EPA Reg. No. 

### MEMPHIS, TN 

### 38117
Product Name 

# o Check if this is a new address

Section -II 

# := Amendment

- Explain below. Final printed labels in response 10 Agency leller daled
Resubmission in response to Agency leiler dated

__ 

# ! "Me Too" Application 

# F 

# "

- E",,;o b,'ow. Olh"

- E"I,;o b,'ow

'II. Use additional I if necessary. (For 

### i I and
, II.)

Submission of 8-Month Response in support of Diuron Product Specific Data Cali-In dated October 28, 2005.

Section**~** 

### III

I ill : i ;**~II ~I"**  

### Sol,bl,**~Type<** DYes' 

# R**~~s** yeo Melal 

# o No : No Plaslic

## ~~~e;~ No. pee ' 

# ,,,. NO. 

### pee Glass 

### *Ceriification must 

# , wgl. I wgt 

# , Paper 

### be submitted i i 

### 1011 

# " 4. 81"",**K'~II'** II 

### 1 oIL", 

# o label 

# o Container 

## =j On Label



### : 001 " i 

### tPcod,ot 6. Manner in Which Label is Affixed 10 Producl ; 

# i**~'P';9i",d** 

# o Olher

Section**~** IV



### 1.**Coo~ot** 

### Po;ol (e I

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### " 10 

# pro"'"

.

# N~7~L WASHBURN 

# I

# TIII~EGULATORY AFFAIRS MANAGER . I 

# "ce, Code) 

# :"" "


### , ' 

### 8
6. ".ale i i 

### I Ihe slalemenls I have made on Ihis form and all allachments Iherelo are true, accurale and complele.' I' , • ' Received thai any knowlngly false or misleading slalemenl may be punishable by fine or imprisonmenl or both**~Stal7lped}** 

# " law. 

### ' 

## "

p 

### " 2. I

# ~ET~'~LATORY AFFAIRS MANAGER ,



# C-z,: ,L =L 

# 0, ,;., 

### , 

### , ,J,

,

# ~1~r~~;';;'BURN 5. 

# "at,
June 

### 30, 2006 '"

, 

### , 

## " ,
EPA Form 8570·1 (Rev. 8-94) 

# oc. I Whlt,-, i i., .'1 

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# "Page20f4UuitedStatesEnvirorunentalProtectionOMBApproval2070-0to7AgencyWashington,D_C20460OMBApprova12070-00S7" "STATUSANDREGISTRANT'SRESPONSE"NSTRUCTIONS:Pleasetypeor9rintinink.reatc<>:re(ullrtheattachedinstructionsandsupplytheinformationrequestedonthisform.Jseadditionalsheet(s)ifnecessaty."""CompanyNameandAddress2.Case#andName3.DateandTypeofDCIandNumber""MICRO-FLOCOMPANyLLC'"0046Diuron28-0ct-2005' ".., ,,"530OAKCOURTDRIVE....,"PRODUCTSPECIFICMEMPHIS,TN38117ID#PDCI-035505-24653EPAReg.No.51036-429I.Guideline5.Study Titlep6.Use7.Test8.Timeg.RegistrantRProgress0ReportsPatternSubstanceFrameResponseT(Months)0C0L12330.6304',Odor(17)A,8,C,D,E,F,G,H,I,TGAI/MP/EP8IJ,K,L,M,N,030.6313Stabilitytosunlight,normalandelevated(5,6)A,B,C,D,E,F,G,H,I,TGAI8temperatures,metals,andmetationsJ,K,L,M,N,O30.6314Oxidizingorreducingaction(7)A,B,C,D,E,F,G,H,I,MP/EP810J,K,L,M,N,030.6315Flammability(8)A,B,C,D,E,F,G,H,I,MP/EP810J,K,L,M,N,030.6316Explodability(9)A,B,C,D,E,F,G,H,I,MP/EP81J,K,L,M,N,030.6317Storageslabilityofproduct(10)A,B,C,D,E,F,G,H,I,MP/EP8qJ,K,l,M,N,030.6319Miscibility(12)A,B,C,D,E,F,G,H,I,MP/EP81J,K,L,M,N,030.6320Corrosioncharacteristics(14)A,B,C,D,E,F,G,H,I,MP/EPB4-J,K,L,M,N,030,6321Dielectricbreakdownvdtage(15)A,B,C,D,E,F,G,H,I,MP/EPB7J,K,L,M,N,030.7000pHofwatersolutionsorsuspensions(3,4)A,B,C,D,E,F,G,H,I,J,K,L,M,N,0TGAI/MP/EPBr.,10.7050UVIVisibleabsorptionA,B,C,D,E,F,G,H,I,TGAI/PAI8J,K,L,M,N,0itialtoindicatecertificationastoinformationonthispageOGDate("J3D!010)11textofcertificationisonpageone).-_..._...Page3of4UnitedStatesEnvironmentalProtectionOMBApprovat2070-0t07AgencyWashington,D.C.20460OMBApprovat2070-0057STATUSANDREGISTRANT'SRESPONSE>JSTRUCTIONS:Pleasetypeor:):Jrintinink.Plea!terea0c{!re!ull1:'theattachedinstructionsandsupplytheinformationrequestedonthisform.IseadditionalsheeUs)Ifnecessary.CompanyNameandAddress"2.Case#andName3.DateandTypeofDCIandNumber,,MICRO-FLOCOMPANYLLC.,,0046Diuron28-0ct-2005-,.530OAKCOURTDRIVEPRODUCTSPECIFICMEMPHIS,TN38117EPAReg.No.51036-429ID#PDCI-035505-24653Guideline5.StudyTitlep6.Use7,Test8.Time9.RegistranRProgress0ReportsPatternSubstanceFrameResponsetumberT(Months)0C0L12330.7100Viscosity(11)A,B,C,D,E,F,G,H,I,J,K,L,M,N,0MP/EP8IJJ30.7200Mellingpoint/meltin9range(18,19)A,B,C,D,E,F,G,H,I,TGAI8J,K,L,M,N,030.7220Boilingpoint/boilingrange(20.21)A,B,C,D,E,F,G,H,I,TGAI8J,K,L,M,N,010.7300Density/relativedensity(22,23)A,B.C,D,E,F,G,H,I,TGAI/MP/EP8IeJ,K,L,M,N,030.7370Dissociationconstantinwater(39.40)A,B,C,D,E,F,G,H,I,TGAIorPAl8J,K,L,M,N,030.7550Partitioncoefficient(n-octanot/water).shakeflask(1)A,B,C,D,E,F,G,H,I,TGAI/PAI8methodJ,K,L,M,N,O30.7570Partitioncoefficient(n-octanolfwater),estimationby(2)A,B,C,D,E,F,G,H,I.TGAI/PAI8liquidchromatographyJ,K,L.M,N,010.7840Watersolubility;Columnelutionmethod,shakeflask(24)A,B,C,D,E,F,G,H,I,TGAIorPAl8methodJ,K,L,M,N,010.7860Watersolubility,generatorcolumnmelhod(25)A,B,C,D,E,F,G,H,I,TGAIorPAl8J,K,L,M.N,010.7950Vaporpressure(26,27)A,B,C,D,E,F,G,H,I,TGAIorPAl8J,K,L,M,N,0TQxicQIQgy:Data·tialloindicatecertificationastoinformationonthispage6CvDatetol3dowofcertificationisonpageone).Page4of4UnitedStatesEnvironmentalProtectionOMBApproval2070-0107AgencyWashington,D.C.20460OMBApprovat2070-0057REQUIRE'V/!ll\!'i'SSTATUSANDREGISTRANT'SRESPONSENSTRUCTIONS:Pleasetypeor:printinink.rea:!c:mJultytheattachedinstructionsandsupplytheinformationrequestedonthisform_Jseadditionalsheet(s)ifnecessary.ICompanyNameandAddress""..--" "2.Case#andName3.Date andTypeofDCIandNumber"..MICRO-FLOCOMPANYllC-".- -.'.'.--0046DiuronZ8-0ct-Z005."530OAKCOURTDRIVE".PRODUCTSPECIFICMEMPHIS,TN38117ID#PDCI-035505-24653EPAReg.No.51036--429I,Guideline5.StudyTitle,6.Use7.Test8,Time9.RegistrantRProgress0ReportsPatternSubstanceFrameResponseT(Months)0C0L1 2370.1100AcuteOralToxicity(49)A,B,C,D,E,F,G,H,I,TGAI,EP,diluteEP?8IJ,K,l,M,N,070.1200Acutedermaltoxicity(41,.42)A,B,C,D,E,F,G,H,I,TGAI,EP,diluteEP?8IJ,K,l,M,N,O70.1300AcuteinhalationtoxiCity(48)A,8,C,D,E,F,G,H,I,TGAI&EP8IJ,K,l,M,N,070,2400Acuteeyeirritation(43)A,B,C,D,E,F,G,H,I,TGAI&EP8IJ,K,l,M,N,070.2500Acutedermalirritation(44,45)A,B,C,D,E,F,G,H,1.TGAI&EP8IJ,K,l,M,N,070.2600Skinsensitization(46,47)A,S,C,D,E,F,G,H,I,J,K,l,M,N,0TGAI&EP8IitialtoindicatecertificationastoinformationonthispageDLDDate(j3010&JIItextofcertificationisonpageone).-----------"---

### Micro Flo Company LLC P.O. Box 772099 Memphis, TN 38117

PRODUCT NAME: Thidiazuron-Diuron EC EPA File Symbol: 51036-429

DATA WAIVER REQUEST

OPPTS Guideline 830.6316 PAGE 1

The purpose of this test is to obtain information and determine the explodability for a product

Thidiazuron-Diuron EC is made up with solvents. of the formulation. The 

## remaining components are 

## active ingredients and emulsifiers.

The physical and chemical characteristics of the solvents are as follows:



### For this reason we are requesting a 

## waiver of this data requirement.

, 

### " "

" " , » "



### ,



# . ;' ,Reference:"

" )}



### , 

### Produc(PNfperties Test Guidelines: OPPTS 830.1000, Background for 'ProducI6'rdperties Test Guidelines; EPA 712-C-96-310, August 1996

# THIDIAZURON-DIURON EC

COTTON DEFOLIANT

For Agricultural Use Only
ACTIVE INGREDIENTS: Thidiazuron: N-phenyl-N'-1 ,2,3-thidiazol-5-ylurea*

............ '

........... 12% Diuron: 3-(3,4-dichlorophenyl)-1, 1-dimethylurea*,

.. ,."

...................................................... 6% OTHER INGREDIENTS:

.......................................................................................... 82% 

### TOTAL 100%

Contains 1 lb. Thidiazuron per gallon and 0.5 lb. Diuron per gallon

KEEP OUT OF REACH OF CHILDREN 

## DANGER

- PELIGRO
5i usled no entiende la etiqueta, busque a alguien para que se la explique a usled en detalle. (If 

### you do not understand this label, find someone to explain 

### it to you in detail.)

FIRST AID IF ON SKIN OR 

# • Take off contaminated clothing. CLOTHING: 

## • Rinse skin immediately with plenty of water for 15-20 minutes.


# • Call a 

### Doison control center or doctor for treatment advice. IF IN EYES: 

## • Hold eye open and rinse slowly and gently with water for 15-20 minutes.


# • Remove contact lenses, 

### if present, after the firs! 5 minutes, then continue rinsing.



## • Call a poison control center or doctor for treatment advice. IF INHALED: 

# • Move person to fresh air.



## • If 

### person is nol breathing, call 911 or an ambulance, then give artificial respiration, preferably mouth-Io-mouth is possible.



## • Call a Doison control center or doctor for treatment advice. IF SWALLOWED: 

# • Immediately call a poison control center or doctor for treatment advice.



## • Do not induce vomiting unless told to do so by 

### a poison control center or doctor.


# • Have person sip a glass or water if able to swallow.



## • Do not Qive anything by mouth to an unconscious person. NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate the use of gastric lavage.

HOT LINE NUMBER 

### Have the product container or label with you when calling a poison control center or doctor

or going for treatment. EMERGENCY NUMBERS:



### , " 

### Transportation or spill, call CHEMTREC 

### 800-424-9300. 

## • Human and Animal health, 

### 866-303-6952 ' 

### , 

## • , ,

, , ,)' ' 

### , ,

,

, ' SEE INSIDE (SIDE PANEL) FOR ADDITIONAL PRECAUTIONS AND USE DIREctiONS



## . " 

### "

EPA Reg. No. 

### 51036-429 ADXXXXXX



### Manufactured by Micro Flo Company LLC 

### P. O. Box 772099 Memphis, TN 

### 38117**Filen~nJe: Thjdj~7.uron-Djuron**  EC (429·081705) (RED 062806) clean 

### EPA Est. No. 

### 510'3S'-G'A-001

, 

# " NET CONTENTS': _'_' _' _--' " "



### Page 1 , , ' >



### ,

### PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS AND DOMESTIC ANIMALS DANGER Corrosive. Causes irreversible eye damage. Causes bums. Harmful if inhaled. Do not get in eyes, on skin, or on clothing. Avoid breathing dust or spray mist. Prolonged or frequently repeated skin-contact may cause aJlergic reactions in some individuals.

PERSONAL PROTECTIVE EQUIPMENT Some materials that are chemical-resistant to this product are barrier laminate or butyl rubber gloves. If you want more options, follow the instructions for category C on an EPA chemical-resistance category selection chart. All pilots, flaggers, and groundboom applicators must wear:

• Long-sleeved shirt and long pants and,

• Shoes plus socks All mixers, loaders, other applicators, and other handlers must wear:

• Long-sleeved shirt and long pants,

• Shoes plus socks,

• Chemical resistant gloves, such as barrier laminate or butyl rubber gloves • A NIOSH-approved dust/mist filtering respirator with any N 2

, 

### R, P or HE filter or an NIOSH-approved dust/mist filtering respirator with approval number prefix TC-21 C.

• Chemical-resistant apron when mixing, loading, or cleaning equipment or spills Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry.

ENGINEERING CONTROLS STATEMENT Pilots must use an enclosed cockpit that meets the requirements, listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240{d){6)]. Flaggers supporting aerial applications must use an enclosed cab that meets the definition in the Worker Protection Standard for Agricultural Pesticides [40 CFR 170.240{d){5)] for dermal protection. In addition, flaggers must wear long-sleeved shirt, long pants, shoes, and socks.

USER SAFETY RECOMMENDATIONS Users should:



## •

• Wash hands thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco, or using the toilet.

• Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing.

• Remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing.

ENVIRONMENTAL HAZARDS For terrestrial uses, do not apply directly to water, or to areas where surface water is present, {'s 

### to intertidal areas below the mean high water mark, except as specified on this label for application to rice.', Do not contaminate water when disposing of equipment wash waters. Apply 

### thi&:**'pT?d~ct** only as specified on this label. ' , .



### , , 

# "

-" 

### , 

### ",


### , ",



### ,

Filename: Thidiazuroo-DiufOll EC (429·081705) (RED 062806) clean 

### Page 2STORAGE AND DISPOSAL Do not contaminate water, food, or feed by storage or disposal.

PESTICIDE STORAGE: Store this product in a cool, dry place in its original container only. Container should be closed when not in use. Do not expose the product to open flame excessive heat. Store in original container and keep closed.



### PESTICIDE DISPOSAL: Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of Federal law. If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous Waste representative at the nearest EPA Regional Office for guidance.

CONTAINER DISPOSAL: Triple rinse (or equivalent); then offer for recycling or reconditioning, or puncture and dispose of in sanitary landfill, or by other procedures approved by State and local authorities. DO NOT REUSE EMPTY CONTAINER

PHYSICAL OR CHEMICAL HAZARDS Do not use or store near heat or open flame. To Contain a Spill: Absorb liquid by covering it with cat litter, commercial clay, lime, sand, sawdust, or soda ash. Once absorbed, bury the cleaning materials and cleanse the spill area with a detergent and water solution.

GENERAL INFORMATION TH1D1AZURON-DIURON EC is a harvest aid for cotton, used for leaf removal prior to harvest. THIDIAZURON-DIURON EC can be applied in most weather conditions, both warm and cool.

USE PRECAUTIONS This product is not to be applied through any type of irrigation system. Effectiveness of TH1DIAZURON-DIURON EC will be reduced if rainfall occurs within 12 hours post application. Foliage from treated plants or gin trash is not to be fed to livestock.

Rotation to the following crops requires the minimum specified periods below after the last application of THIDIAZURON-DIURON EC: small grains, sorghum, corn, or root crops (except carrots, onions)

................................. two (2) months legumes (including alfalfa) or leafy vegetable (except lettuce}

........................................ two (2) months cole crops, garlic, safflower, tomatoes, and watermelon

................................................ two (2) months carrots

............................................................................................................. three (3) months onions

............................................................................................................... four (4) months cantaloupe, honeydew melon/casaba melon, muskmelon, or peppers

........................... five (5) months lettuce

........................ when soil has been deep-plowed (12-15 inches)

....................... two (2) months

OR lettuce

............. when soil is only disced (4-6 inches)

.................................... nine (9) months All other crops

................................................................................................ twelve (12) months

Special Note for inter-cropped grains and legumes planted either as cover crops or planted into treated fields before the minimum two (2) month plant back time after the final THIDIAZURON-DIURON EC application: Any such crops are prohibited for use as feed or food and may be used only as cover crops.

Do not use immature crops for food or feed.

Prevent spray drift from contacting crops other than mature cotton, since this product may defoliate or injure other plant species.

Mixtures with organophosphates can increase nontarget crop phytotoxicity. Exercise additional care when lettuce, citrus, cantaloupes or any other edible crops are adjacent to THIDIAZURON-DIURON EC treated cotton fields.

Filename: Thidiuzuron-Diuron EC (429-081705) (RED 062806) clean 

### Page 3PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL ONTO NONTARGET CROPS 

### Under windy weather conditions, applications of THIOIAZURON-DIURON EC may drift to non-target
crops. The following procedures can help reduce the potential for drift:



### • If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground applications of THIDIAZURON-DIURON EC.

• Nozzle pressure of 20-30 psi is recommended.

• Do not apply this product during a temperature inversion because drift potentia! is high. In addition, do not apply this product if the development of a temperature inversion appears likely during the application period.

• Do not apply this product 

### by ground within 100 fee! or 

### by air within 0.5 mile of lettuce.

RIO GRANDE VALLEY OF TEXAS PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL The following procedures can help reduce the potential for drift:

• If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground applications of THIDIAZURON-DIURON EC. If wind speeds are less than ten (10) miles per hour, observe local recommendations from your State Extension Cotton Specialist.

• Nozzle pressure of 20-30 psi is recommended.

• Do not apply this product during a temperature inversion because drift potential is high. In addition, do not apply this product if the development of a temperature inversion appears likely during the application period.

• Use the maximum nozzle orifice size that provides proper coverage and deposition of this product.

• CITRUS AREAS: Do not apply this product by ground within 0.5 mile or by air within 5 miles downwind of citrus in flush.

DIRECTIONS FOR USE 

### It is a violation of Federal law to use this product in a manner inconsistent with its labeling.

Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application.

Filename: ThidiazufOll-Diuron EC (429-081705) (RED 062806) clean 

### Page 4AGRICULTURAL USE REQUIREMENTS Use this product only in accordance with jts labeling and with the Worker Protection Standard, 40 CFR 

### Part 170. This Standard contains requirements for the protection of agricultural workers on farms, forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for training, decontamination, notification, and emergency assistance. 

### It also contains specific instructions and exceptions pertaining to the statement on this label about personal protective equipment (PPE), and**restrjcted~entry** interval. The requirements in this box only apply to uses of this product that are covered 

### by the Worker Protection Standard.

Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 12 hours. For minimum early entry PPE use the following: PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water, is:

• Coveralls

• Shoes plus socks

• Chemical-resistant gloves made of any waterproof material



## •

SPRAY DRIFT Requirements for reducing spray drift for diuron ground and aerial applications: Use best practices to avoid drift to all other crops and non-target areas. Do not apply when conditions favor drift from target areas. The interaction of many equipment- and weather-related factors determine the potential for spray drift. Avoiding spray drift at the application site is the responsibility of the applicator. The applicator must follow the most restrictive precartions to avoid drift, including those found in this labeling as well as applicable state and local regulations and ordinances. A drift control agent may reduce drift, however, it may also decrease weed control.

Make aerial or ground applications only when the wind speed is less than or equal to 10 miles per hour.

Do not make aerial or ground applications into temperature inversions.

Apply with medium or coarser spray (according to ASAE standard 572) for standard nozzles.

Additional requirements for ground appllcations: When applying to crops, apply with nozzle height no more than 2 feet above the ground or crop canopy. When applying to non-crop areas, use lowest nozzle height consistent with safety and efficacy. Direct
spray into target vegetation.

Additional requirements for aerial appllcations: The spray boom should be mounted on the aircraft so as to minimize drift caused by wing tip vortices. The boom length must not exceed 75% of the wingspan or 90% of rotor blade diameter.

Use upwind swath displacement.

When applying to crops, do not release spray at a height greater than 6 to 10 feet above the ground or crop canopy. When applying to non-crop areas, apply at a minimum safe altitude above the area being treated.

Do not apply by air if sensitive non-target crops are within 100 feet of the application site.

TIME OF APPLICATION THJDIAZURON-DIURON EC defoliant applications are to be made only on mature cotton plants when the uppermost harvestable boll is mature. Boll maturity is defined as 1) when a boll is squeezed between thumb and finger, it does not dent; 2) when cutting a cross section with a sharp knife is difficult; 3) when seeds in cross section lack liquid within the seed coat or outer edges of seed coat are light brown; and 4) when fully developed cotyledons are present.

Filcllamc: Thidiazuron·DiUl'on EC (429-081705) (RED 062806) clcan 

### Page 5

### Make applications ofTHIDIAZURON-DIURON EC at least 5 days prior to expected harvest date.

NOTE: Adequate defoliation with THIOIAZURON-OIURON EC depends on three factors:

• Cotton is actively growing.

• High relative humid·lty.

• Cotton plant leaves are turgid and not desiccated.

ATTENTION: Desiccation and/or leaf freezing may occur during periods of high temperature when adjuvants are added to THIDIAZURON-DIURON EC application solution. Products and adjuvants known to cause desiccation of cotton leaf tissue should not be used.

Under low nighttime temperatures (below 60°F) or otherwise adverse conditions, this product, when used alone, may provide less than expected defoliation and 

### J or regrowth suppression.

APPLICATION INFORMATION Use an adequate volume of water with the recommended amount of THIDIAZURON-DIURON EC defoliant to uniformly and completely cover leaves. For ground equipment, apply 10

- 25 gallon per acre and by air, use 2 -10 gallons per acre. Maintain agitation during application.

DOSAGE INFORMATION Application Rate: Before harvest, use 0.4-1.0 pints active ingredient/acre (6.4-16 fl. 

### oz.lA).

One gallon of THIDIAZURON-OIURON EC will treat 8 - 20 acres. Refer to the dose rate table below.

In some situations, a follow-up application maybe needed. THIDIAZURON-DIURON EC may be used for this application. Other defoliants may be needed. If additional boll opening is required, Ethephon 6 may be used at recommended rates; see product label for rates and timings. Consult your local State Extension Cotton Specialist recommendations for rateS and timings.

The maximum annual use rate of THIOIAZURON-DIURON EC is 16 oz. per acre per season.

MIXING INSTRUCTIONS 1. Fill spray applicator tank with at least one half of the water to be used 2. Start agitation 3. Add the appropriate volume of THIDIAZURON -DIURON EC 4. Continue agitation and fill tank with the remainder of the water to be used 5. Agitation should continue throughout the application

CALIFORNIA ONLY: PRECONDITIONING When used as a pre-condltioner seven to ten days before applicafion of this or other defoliant compounds, this product will improve the efficacy of such a defoliant application. Before use, observe all product label directions, recommendations and prohibitions on both product's labels.

Application Rate: Use 4-6 f1.0Z. 

### of this product/acre in an aerial application of 2-10 gallons of spray solution or ground application of 10-25 gallons of spray solution

Filename: Thidiazuron-Diuron EC (429-081705) (RED 062806) clean 

### Page 6APPLICATION RATE TABLE 

### for THlDlAZURON DJURON EC 

## · THIDIAZURON·DIURON EC One Gallon of**THIDJAZURON~** 

### Active Ingredients per Acre FonnuJated Product DJURON EC WllJ Treat 

### 6.4 oz.lAcre 20 Acres 0.075 Ibs. ai/Acre (0.4 pt./Acre) 

### 8.8oz.lAcre 15 Acres 0.10 Ibs. Ai/Acre (0.55 pt./Acre)


### 12.8**Oz.lAC~~** 10 Acres 0.15 Jbs. Ai/Acre (0.8 pt./Acre 

### 16.0oz.lAcre 8 Acres 0.1875 Ibs. ai/Acre (1.0 pt./Acre) DO NOT APPLY MORE THAN 1.0 PINT OF THIDIAZURON·DIURON EC PER ACRE PER SEASON.

IMPORTANT CLEAN OUT INSTRUCTIONS When applying THIDJAZURON-DIURON EC, a residue may form in application equipment. This residue



### can best be flushed oul of the spraying system by using a commercial tank cleaner when done while residue is still fresh and moist. DO NOT ALLOW EQUIPMENT TO DRY BEFORE CLEAN OUT. Consult
your State Extension Cotton Specialist for recommended tank cleaners and cleaning procedures.

Use tank cleaner and water immediately after application. Flush the entire system including nozzles, booms, application tanks, sumps, pumps, and transfer lines. Allowing the spray solution to dry in the application equipment can result in residues that are more difficult to remove. Dried residues are extremely difficult to remove. To remove such dried residues, fIJI the affected equipment to capacity with commercial tank cleaner solution and tet it remain for 7 days. Afterwards, the equipment will need to be thoroughly flushed and rinsed.

Spray application equipment that has been inadequately cleaned will contain residue of THIDIAZURON**~** DIURON EC. Such improper cleaning could lead to crop damage in later applications.

Micro Flo Company, LLC assumes no liability due to equipment that has not been properly cleaned.

CONDITIONS OF SALE AND WARRANTY The Directions For Use of this product reflects the opinion of experts based on field use and tests. The directions are believed to be reliable and should be followed carefully. However, it is impossible to eliminate all risks inherently associated with use of this product. Crop injury, ineffectiveness or other unintended consequences may result because of such factors as weather conditions, presence of other materials, or use of the product in a manner inconsistent with its labeling, all of which are beyond the control of MICRO FLO COMPANY LLC ("MICRO FLO") or the Seller. All such risks shall be assumed by the Buyer.

MICRO FLO warrants that this product conforms to the chemical description on the label and is reasonably fit for the purposes referred to in the Directions For Use, subject to the inherent risks, referred to above.

MICRO FLO MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OR MERCHANTABILITY OR ANY OTHER EXPRESS OR IMPLIED WARRANTY. TO THE EXTENT PERMITTED BY LAW, MICRO FLO AND THE SELLER DISCLAIM ANY LIABILITY FOR CONSEQUENTIAL, SPECIAL OR INDIRECT DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. MICRO FLO and the Seller offer this product, and the Buyer and User accept it, subject to the foregoing Conditions of Sale and Warranty which may be varied only by agreement in writing signed by a duly authorized representative of MICRO FLO.

Fi!ename: Thidiazuron-Diuron EC (429-081705) (RED 062806J clean 

### Page 7ECCOTTONDEFOLIANTForAgriculturalUseOnlyACTIVEINGREDIENTS:Thidiazuron:N-phenyl-N'-1,2,3-thidiazol-5-ylurea'".....12%Diuron:3-{3,4-dichlorophenyl)-t,1-dimethylurea'..............................................6%OtherIngredients:....................................................."..............TOTAL..................................................................................................tOO%Contains1lb.Thidiazuronpergallonand0.5Ib.DiuronpergallonKEEPOUTOFREACHOFCHILDRENDANGER-PELIGROSiustednoentiendeIaetiqueta,busqueaalgulenparaqueselaexpliqueaustedendetalle.(Ifyoudonotunderstandthislabel,findsomeonetoexplainittoyouindetail.)FIRSTAIDIFONSKINOR•Takeoffcontaminatedclothing,CLOTHING:•Rinseskinimmediatelywithplentyofwaterfor15-20minutes.•Callapoisoncontrolcenterordoctorfortreatmentadvice.IFINEYES:•HoldeyeopenandrinseslowlyandgenUywithwaterfor15-20minutes.•Removecontactlenses,ifpresent,afterthefirst5minutes,thencontinuerinsing.•Callapoisoncontrolcenterordoctorfortreatmentadvice.IFINHALED:·Movepersontofresh air.•Ifpersonisnotbreathing,call911oranambulance,thengiveartificialrespiration,preferablymouth-to-mouthispossible.•Callapoisonconlrolcenterordoctorfortreatmentadvice.IFSWALLOWED:•Immedialelycallapoisoncontrolcenlerordoctorfortreatmentadvice.•Donotinducevomitingunlesstoldtodosobyapoisoncontrolcenlerordoclor.•Havepersonsipaglassorwaterifabletoswallow,•Donotoiveanvthinobvmouth10anunconsciousperson.NOTETOPHYSiCIAN:Probablemucosaldamagemaycontraindicatetheuseofgastriclavage.HOTLINENUMBERHavetheproductcontainerorlabelwithyouwhencallingapoisoncontrolcenterordoctororgoingfortreatment.EMERGENCYNUMBERS:•Transportationorspill,callCHEMTREC800-424·9300.•Humanhealth,800_832_HElP(4357).•Animalhealth,callASPCAat800·345-4735.Filename.Thidiazuroll-DiuronEC(429-081705)(RED062806)cleanPRECAUTIONARYSTATEMENTSHAZARDSTOHUMANSANDDOMESTICANIMALSDANGERCOrrosive.causesirreversibleeyedamage,Causesburns.Hannfulifinhaled,Donotgetineyes,onskin,oronclothing.Avoidbreathingdustorspraymist.Prolongedorfrequentlyrepeatedskin-contactmaycauseallergicreactionsinsomeindividuals.ENVIRONMENTALHAZARDSForterrestrialuses,donotapplydirectlytowater,ortoareaswheresurfacewalerispresent,ortointertidalareasbelowthemeanhighwatermark,exceptasspecifiedonthislabelforapplicationtorice.Donotcontaminatewaterwhendisposingofequipmentwashwaters.Applythisproductonlyasspecifiedonthislabel.SToRAGEANDDISPOSALDonotcontaminatewater,food,orfeedbystorageord·lsposal.PESTICIDESTORAGE:Storethisproductinacool,dryplaceinitsoriginalconlaineronly.Containershouldbeclosedwhennotinuse.Donotexposetheproducttoopenflameexcessiveheat.Storeinoriginalcontainerandkeepclosed.PESTICIDEDISPOSAL:Pesticidewastesareacutelyhazardous.Improperdisposalofexcesspesticide,spraymixture,ortinsateisaviolationofFederallaw.Ifthesewastescannotbedisposedofbyuseaccordingtolabelinstructions,contactyourStatePesticideorEnvironmentalControlAgency,ortheHazardousWasterepresentativeatthenearestEPARegionalOfficeforguidance.CONTAINERDISPOSAL:Triplerinse(orequivalent);thenofferforreCYClingorreconditioning,orpunctureanddisposeofinsanitarylandfill,orbyotherproceduresapprovedbyStaleandlocalauthorities.DONOTREUSEEMPTYCONTAINERPHYSICAlORCHEMICALHAZARDSDonotuseorstorenearheatoropenflame.ToContainaSpill:Absorbliquidbycoveringitwithcatlitter,commercialclay,lime,sand,sawdust,orsodaash.Onceabsorbed,burythecleaningmalerialsandcleansethespillareawithadelergentandwatersolution.DIRECTIONSFORUSEItisaviolationofFederallawtousethisproductinamannerinconsistentwithitslabeling.SEEATTACHEDBOOKLETFORADDITIONALPRECAUTIONSANDUSEDIRECTIONSEPAReg.No.51036429EPAEst.No.51036-GA-001AD081705NETCONTENTS:___BASELABELPage8ManufacturedbyMicroFloCompanylLCP.O.80x772099MemphiS,TN38117

# THIDIAZURON-DIURON EC

COTTON DEFOLIANT

For Agricultural Use Only
ACTIVE INGREDIENTS: Thidiazuron: N-phenyl-N'-1 ,2,3-thidiazol-5-ylurea*"

..................... 12% Diuron: 3-(3,4-dichlorophenyl)-1, 1-dimethylurea*

............................................................ 6% OTHER INGREDIENTS:

............................................................................... "

......... 82% 

### TOTAL 100%

Contains 1 lb. Thidiazuron per gallon and 0.5 lb. Diuron per gallon

KEEP OUT OF REACH OF CHILDREN 

## DANGER

- PELIGRO
Si usted no entiende la etiqueta, busque a alguien para que 5e 

### la explique a usted en detalle. (If 

### you do not understand this label, find someone to explain 

### it to you in detail.)

FIRST AID IF ON SKIN OR 

# • Take off contaminated clothing. 

### CLOTHING: 

## • Rinse skin immediately with plenty of water for 15-20 minutes.


# • Call a poison control center or doctor for treatment advice. 

### IF IN EYES: 

## • Hold eye open and rinse slowly and gently with water for 15-20 minutes.


# • Remove contact lenses, 

### if present, after the firs! 5 minutes, then continue rinsing.



## • Call a poison control center or doctor for treatment advice. 

### IF INHALED: 

## • Move person to fresh air.



## • If 

### person is not breathing, call 911 or an ambulance, then give 

### artificial respiration, preferably mouth-la-mouth is possible.


# • Call a poison control center or doctor for treatment advice. 

### IF SWALLOWED: 

# • Immediately call a poison control center or doctor for treatment advice.



## • Do not induce vomiting unless told to do so by 

### a poison control center or doctor.


# • Have person sip a glass or water if able to swallow.



## • Do not give anythinq by mouth to an unconscious person. NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate the use of gastric lavage.
HOT LINE NUMBER Have the product container or label with you when calling a poison control center or doctor

or going for treatment. EMERGENCY NUMBERS:



## • Transportation or spill, call CHEMTREC 

### 800-424-9300

. 

# • Human and Animal health, 

### 866-303-6952

SEE INSIDE (SIDE PANEL) FOR ADDITIONAL PRECAUTIONS AND USE DIRECTIONS"

, , ,


### EPA Reg. No. 

### 51036-429 AD X)()()()(X

Manufactured by Micro Flo Company LLC 

### P. O. Box 

### 772099 Memphis, TN 

### 38117

Filename: Thidiazuron-Diuron EC (429-081705) (RED 062806) elean 

### EPA Est. 

### No. 51036-GA-OO'1 NET

### CONT~~T~,:':- __ _

, " "

'"



### ,


### Page 1PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS AND DOMESTIC ANIMALS DANGER Corrosive. Causes irreversible eye damage. Causes burns. Harmful if inhaled. Do not get in eyes, on 

### skin, or on clothing. Avoid breathing dust or spray mis!. Prolonged or frequently repeated**skin~contact** 

### may cause allergic reactions in some individuals.

PERSONAL PROTECTIVE EQUIPMENT Some materials that are**chemical~resistant** to this product are barrier laminate or butyl rubber gloves. If you want more options, follow the instructions for category C on an EPA chemical-resistance category selection char\. 

### All 

### pilots, flaggers, and groundboom applicators must wear:

• Long"sleeved shirt and long pants and,



### • Shoes plus socks All 

### mixers, loaders, other applicators, and other handlers must wear:

• Long-sleeved shirt and long pants,

• Shoes plus socks,

• Chemical resistant gloves, such as barrier laminate or butyl rubber gloves • A NIOSH-approved dust/mist filtering respirator with any N 2

, 

### R, P or HE filter or an NIOSH-approved dust/mist filtering respirator with approval number prefix TC-21C.

• Chemical-resistant apron when mixing, loading, or cleaning equipment or spills Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry.

ENGINEERING CONTROLS STATEMENT Pilots must use an enclosed cockpit that meets the requirements, listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)]. Flaggers supporting aerial applications must use an enclosed cab that meets the definition in the Worker Protection Standard for Agricultural Pesticides [40 CFR 170.240(d)(5)] for dermal protection. In addition, flaggers must wear long-sleeved shirt, long pants, shoes, and socks.

USER SAFETY RECOMMENDATIONS Users should:



## •

• Wash hands thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco, or using the toilet.

• Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing.

• Remove PPE immediately after handling this product. Wash the outside of gloves before removing. As soon as possible, wash thoroughly and change into clean clothing.

ENVIRONMENTAL HAZARDS For terrestrial uses, do not apply directly to water, or to areas where surface water is present, or to intertidal areas below the mean high water mark, except as specified on this label for applicatlon to rice. Do not contaminate water when disposing of equipment wash waters. Apply this product only as specified on this label.

Filename: TIlidiazuron-Diuron EC (429-08)705) (RED 062806) clean 

### Page 2STORAGE AND DISPOSAL Do not contaminate water, food, or feed by storage or disposal.

PESTICIDE STORAGE: Store this product in a cool, dry place in its original container only. Container 

### should be closed when no! in use. Do not expose the product to open flame excessive heat. Store in original container and keep closed.



### PESTICIDE DISPOSAL: Pesticide wastes are acutely hazardous. Improper disposal of excess pesticide, spray mixture, or rinsate is a violation of Federal law. If these wastes cannot be disposed of by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous Waste representative at the nearest EPA Regional Office for guidance.

CONTAINER DISPOSAL: Triple rinse (or equivalent); then offer for recycling or reconditioning, or puncture and dispose of in sanitary landfill, or by other procedures approved by State and local authorities. DO NOT REUSE EMPTY CONTAINER

PHYSICAL OR CHEMICAL HAZARDS Do not use or store near heat or open flame. To Contain a Spill: Absorb liquid by covering it with cat litter, commercial clay, lime, sand, sawdust, or soda ash. Once absorbed, bury the cleaning materials and cleanse the spill area with a detergent and water solution.

GENERAL INFORMATION THIDIAZURON-DIURON EC is a harvest aid for cotton, used for leaf removal prior to harvest. THIDIAZURON-DIURON EC can be applied in most weather conditions, both warm and cool.

USE PRECAUTIONS This product is not to be applied through any type of irrigation system. Effectiveness of THIDIAZURON-DIURON EC will be reduced if rainfall occurs within 12 hours post application. Foliage from treated plants or gin trash is not to be fed to livestock.

Rotation to the following crops requires the minimum specified periods below after the last application ofTHIDIAZURON-DIURON EC: small grains, sorghum, corn, or root crops (except carrots, onions)

................................. two (2) months legumes (including alfalfa) or leafy vegetable (except lettuce)

........................................ two (2) months cole crops, garlic, safflower, tomatoes, and watermelon

................................................ two (2) months carrots

............................................................................................................. three (3) months onions

.............................................................................................................. .four (4) months cantaloupe, honeydew melon/casaba melon, muskmelon, or peppers

.......................... .five (5) months lettuce

........................ when soil has been deep-plowed (12-15 inches)

....................... two (2) months

OR lettuce

............. when soil is only disced (4-6 inches)

...... .......... .. .............. nine (9) months All other crops

................................................................................................ twelve (12) months

Special Note for inter-cropped grains and legumes planted either as cover crops or planted into treated fields before the minimum two (2) month plant back time after the final THIDIAZURON-DIURON EC application: Any such crops are prohibited for use as feed or food and may be used only as cover crops.

Do not use immature crops for food or feed.

Prevent spray drift from contacting crops other than mature cotton, since this product may defoliate or injure other plant species.

Mixtures with organophosphates can increase nontarget crop phytotoxicity. Exercise additional care when lettuce, citrus, cantaloupes or any other edible crops are adjacent to THIDIAZURON-DIURON EC treated cotton fields.

Filename: ThidiaZUl'on·DillfOll EC (429-081705) (RED 062806) clean 

### Page 3

### PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL ONTO NONTARGET CROPS Under windy weather conditions, applications of THIDIAZURON-DIURON EC may drift to non-target crops. The following procedures can help reduce the potential for drift:

• If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground applications of THIDIAZURON-DIURON EC.

• Nozzle pressure of 20-30 psi is recommended.

• Do not apply this product during a temperature inversion because drift potential is high. In addition, do not apply this product if the development of a temperature inversion appears likely during the application period.

• Do not apply this product by ground within 100 feet or by air within 0.5 mile of lettuce.

RIO GRANDE VALLEY OF TEXAS PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL The following procedures can help reduce the potential for drift:

• If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground applications of THIDIAZURON-DIURON EC. If wind speeds are less than ten (10) miles per hour, observe local recommendations from your State Extension Cotton Specialist.

• Nozzle pressure of 20-30 psi is recommended.

• Do not apply this product during a temperature inversion because drift potential is high. In addition, do not apply this product if the development of a temperature inversion appears likely during the application period.

• Use the maximum nozzle orifice size that provides proper coverage and deposition of this product.

• CITRUS AREAS: Do not apply this product by ground within 0.5 mile or by air within 5.miles downwind of citrus in flush.

DIRECTIONS FOR USE It is a violation of Federal law to use this product in a manner inconsistent with its labeling.

Do not apply this product in a way that will contact workers or other persons, either directly or through drift. Only protected handlers may be in the area during application.

Filename: Thidia7.uron-Diuron EC (429-081705) (RED 062806) clean 

### Page 4AGRICULTURAL USE REQUIREMENTS Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR 

### Par! 170. This Standard contains requirements for the protection of agricultural workers on farms. forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific instructions and exceptions pertaining to the statement on this label about personal protective equipment (PPE), and**restrjcted~entry** interval. The requirements in this box only apply to uses of this product that are covered 

### by the Worker Protection Standard.

Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 12 hours. For minimum early entry PPE use the following: PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water, is:

• Coveralls

• Shoes plus socks

• Chemical-resistant gloves made of any waterproof material



## •

SPRAY DRIFT Requirements for reducing spray drift for diu ron ground and aerial applications: Use best practices to avoid drift to all other crops and non-target areas. Do not apply when conditions favor drift from target areas. The interaction of many equipment- and weather-related factors determine the potential for spray drift. Avoiding spray drift at the application site is the responsibility of the applicator. The applicator must follow the most restrictive precartions to avoid drift, including those found in this labeling as well as applicable state and local regulations and ordinances. A drift control agent may reduce drift, however, it may also decrease weed control.

Make aerial or ground applications only when the wind speed is less than or equal to 10 miles per hour.

Do not make aerial or ground applications into temperature inversions.

Apply with medium or coarser spray (according to ASAE standard 572) for standard nozzles.

Additional requirements for ground applications: When applying to crops, apply with nozzle height no more than 2 feet above the ground or crop canopy. When applying to non-crop areas, use lowest nozzle height consistent w·lth safety and efficacy. Direct spray into target vegetation.

Additional requirements for aerial applications: The spray boom should be mounted on the aircraft so as to minimize drift caused by wing tip vortices. The boom length must not exceed 75% of the wingspan or 90% of rotor blade diameter.

Use upwind swath displacement.

When applying to crops, do not release spray at a height greater than 6 

## to 10 feet above the ground or crop canopy. When applying to non-crop areas, apply at a minimum safe altitude above the area being treated.

Do not apply by air if sensitive non-target crops are within 100 feet of the application site.

TIME OF APPLICATION THIDIAZURON-OIURON EC defoliant applications are to be made only on mature cotton plants when the uppermost harvestable boll is mature. Boll maturity is defined as 1) when a boll is squeezed between thumb and finger, it does not dent;" 2) when cutting a cross section with a sharp knife is difficult; 3) when seeds in cross section lack liquid within the seed coat or outer edges of seed coat are light brown; and 4) when fully developed cotyledons are present.

Filename: Thidiazuron-Diuron EC (429-081705) (RED 062806) clean 

### Page 5

### Make applications of THIDIAZURON-DIURON EC at least 5 days prior to expected harvest date.

NOTE: Adequate defoliation with THIDIAZURON-DIURON EC depends on three factors:

• Cotton is actively growing.

• High relative humidity.

• Cotton plant leaves are turgid and not desiccated.

ATTENTION: Desiccation and/or leaf freezing may occur during periods of high temperature when adjuvants are added to THIDIAZURON-DIURON EC application solution. Products and adjuvants known to cause desiccation of cotton leaf tissue should not be used.

Under low nighttime temperatures (below 60°F) or otherwise adverse conditions, this product, when used alone, may provide less than expected defoliation and / or regrowth suppression.

APPLICATION INFORMATION Use an adequate volume of water with the recommended amount of THIDIAZURON-DIURON EC defoliant to uniformly and completely cover leaves. For ground equipment, apply 

### to

- 25 gallon per acre and by air, use 2 -10 gallons per acre. Maintain agitation during application.

DOSAGE INFORMATION Application Rate: Before harvest, use 0.4-1.0 pints active ingredient/acre (6.4-16 fl. oz.lA).

One gallon of THIOIAZURON-DIURON EC will treat 8 - 20 acres. Refer to the dose rate table below.

In some situations, a follow-up application maybe needed. THIDIAZURON-OIURON EC may be used for this application. Other defoliants may be needed. If additional boll opening is required, Ethephon 6 may be used at recommended rates; see product label for rates and timings. Consult your local State Extension Cotton Specialist recommendations for rates and timings.

The maximum annual use rate of THIDIAZURON-DIURON EC is 16 oz. per acre per season.

MIXING INSTRUCTIONS 1. Fill spray applicator tank with at least one half of the water to be used 2. Start agitation 3. Add the appropriate volume of THIDIAZURON -DIURON EC 4. Continue agitation and fill tank with the remainder of the water to be used 5. Agitation should continue throughout the application

CALIFORNIA ONLY: PRECONDITIONING When used as a pre-conditioner seven to ten days before application of this or other defoliant compounds, this product will improve the efficacy of such a defoliant application. Before use, observe all product label directions, recommendations and prohibitions on both product's labels.

Application Rate: Use 4-6 f1.02. of this product/acre in an aerial application of 2-10 gallons of spray solution or ground application of 10-25 gallons of spray solution

Filename: Thidiazuron-Diuron EC (429-081705) (RED 062806) clean Page 6APPLICATION RATE TABLE forTHtDIAZURON DIU RON EC



# - THIDIAZURON-DIURON EC 

### One Gallon of**TH[D[AZURON~** 

### Active Ingredients per Acre Formulated Product D[URON EC Will Treat 6.4 oz.lAcre 20 Acres O.075Ibs. ai/Acre 

### (004 pUAere) 

### 8.8 oz.lAcre 15 Acres 0.10 Ibs. Ai/Acre (0.55 pUAere) 

# ;,2.8**OZ'/Ae:~** 10 Acres 0.15 Ibs. Ai/Acre 0.8 pt.!Acre 16.0 oz.lAcre 

### 8 Acres 0.1875 tbs. ai/Acre (1.0 pUAere) DO NOT APPLY MORE THAN 1.0 PINT OF THIDIAZURON-DIURON EC PER ACRE PER SEASON.

IMPORTANT CLEANOUT INSTRUCTIONS When applying**TH[DIAZURON~D[URON** EG, a residue may form in application equipment. This residue

can best be flushed out of the spraying system by using a commercial tank cleaner when done while residue is still fresh and moist. DO NOT ALLOW EQUIPMENT TO DRY BEFORE CLEANOUT. Consult
your State Extension Cotton Specialist for recommended tank cleaners and cleaning procedures,

Use tank cleaner and water immediately after application, Flush the entire system including nozzles, booms, application tanks, sumps, pumps, and transfer lines. Allowing the spray solution to dry in the application equipment can result in residues that are more difficult to remove. Dried residues are extremely difficult to remove. To remove such dried residues, fill the affected equipment to capacity with commercial tank cleaner solution and let it remain for 7 days. Afterwards, the equipment will need to be thoroughly flushed and rinsed.

Spray application equipment that has been inadequately cleaned will contain residue of THIDIAZURON

- DIURON EC. Such improper cleaning could lead to crop damage in later applications.

Micro Flo Company, LLC assumes no liability due to equipment that has not been properly cleaned.

CONDITIONS OF SALE AND WARRANTY The Directions For Use of this product reflects the opinion of experts based on field use and tests. The directions are believed to be reliable and should be followed carefully. However, it is impossible to eliminate all risks inherently associated with use of th'ls product. Crop 'Injury, ineffectiveness or other unintended consequences may result because of such factors as weather conditions, presence of other materials, or use of the product in a manner inconsistent with its labeling, all of which are beyond the control of MICRO FLO COMPANY LLC ("MICRO FLO") or the Seller. All such risks shall be assumed by the Buyer.

MICRO FLO warrants that this product conforms to the chemical description on the label and is reasonably fit for the purposes referred to in the Directions For Use, subject to the inherent risks, referred to above.

MICRO FLO MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OR MERCHANTABILITY OR ANY OTHER EXPRESS OR IMPLIED WARRANTY. TO THE EXTENT PERMITIED BY LAW, MICRO FLO AND THE SELLER DISCLAIM ANY LIABILITY FOR CONSEQUENTIAL, SPECIAL OR INDIRECT DAMAGES RESULTING FROM THE USE OR HANDLING OF THIS PRODUCT. MICRO FLO and the Seller offer this product, and the Buyer and User accept it, subject to the foregoing Conditions of Sale and Warranty which may be varied only by agreement in writing signed by a duly authorized representative of MICRO FLO.

Filename: Thidiazuron-Diuron EC (429·081705) (RED 062806) clean Page 7THIDIAZURONwDIURONECCOTTONDEFOLIANTForAgriculturalUseOnlyACTIVEINGREDIENTS;Thidiazuron:N-phenyl-N'-1,2,3_thidiazol_5_ylurea"...•.•......12%Diuron:3-(3,4-dichlorophenyl)-1,1-dimethylurea·•..•.................•..•.........•..•.•.........6%OtherIngredients;....................................................................................82%TOTAL.......••.•.................••.....•........•.•............•.•.•................•.•..........•..•.100%Containstlb.Thidiazuronpergallonand0.5lb.DiuronpergallonKEEPOUTOFREACHOFCHILDRENDANGER-PELIGROSiustednoentiendelaettqueta,busqueaalguienparaqueselaexpUqueaustedendetalle.(Ifyoudonotunderstandthislabel,findSomeonetoexplainittoyouindetail.)•CLOTHING:•••••••off_Rinseskinimmediatelywithplentyofwaterfor15-20minutes.20minules.Removecontactlenses,ifpresent,afterthefirst5minuleS.thencontinuerinsing.Ifpersonisnotbreathing,call911oranambulance,thengiveartificialrespiration,preferablymouth-to-mouthispossible.cenlerortrealmentDonotinducevomitingunlesstoldtodosobyapoisoncontrolcenterordoctor.Havepersonsipaglassorwaterifabletoswallow.DonotgiveanythingbymouthtoanUIobablemucosaldamagemaycontyouTransportationorspill,caltCHEMTREC800-424-9300.•HumanFilename.·rhidial.\\roll-Diul'OllEC(429-081705)(RED062806)cleanPRECAUTIONARYSTATEMENTSHAZARDSTOHUMANSANDDOMESTICANIMAlSDANGERCorrosive.Causesirreversibleeyedamage.Causesburns.Harmfulifinhaled.Donotgetineyes.onskin,oronclothing.Avoidbreathingdustorspraymisl.Prolongedorfrequentlyrepeatedskin-contactmaycauseallergicreacJionsinsomeindividuals.ENVIRONMENTALHAZARDSForterrestrialuses,donotapplydirectlytowater,ortoareaswheresurfacewaterispresent,ortointertidalareasbelowthemeanhighwatermark,exceptasspecifiedonthislabelforapplicationtorice.Donotcontaminatewaterwhendisposingofequipmentwashwaters.Applythisproductonlyasspedfiedonthislabel.STORAGEANDDiSPOSAlDonotcontaminatewater,food,orfeedbystorageordisposal.PESTICIDESTORAGE:Storethisproductinacool,dl)'placeinitsoriginalcontaineronly.Containershouldbeclosedwhennotinuse.DonotexposetheprodUCItoopenflameexcessiveheal.Storeinoriginalcontainerandkeepclosed.PESTICIDEDISPOSAL:Pesticidewastesareacutelyhazardous.Improperdisposalofexcesspesticide,spraymixture,orrinsateisaviolationofFederal law.Ifthesewaslescannotbedisposedofbyuseaccordingtolabelinslructions,contactyourStatePesticideorEnvironmentalControlAgency,ortheHazardousWasterepresenlaliveatthenearestEPARegionalOfficeforguidance.CONTAINERDISPOSAL:Triplerinse(orequivalent):thenofferforrecyclingorreconditioning,orpunctureanddisposeofinsanital)'landfill,orbyotherproceduresapprovedbyStateandlocalauthorities.DONOTREUSEEMPTYCONTAINERPHYSICALORCHEMICAlHAZARDSDonotuseorslorenearheatoropenflame.ToContainaSpilt:Absorbliquidbycoveringitwithcatlitter,commercialclay,lime,sand,sawdust,orsodaash.Onceabsorbed,bul)'thecleaningmaterialsandcleansethespiltareawithadetergentandwatersolution.DIRECTIONSFORUSEItisaviolationofFederallawtousethisproductinamannerinconsistentwithitslabeling.SEEATTACHEDBOOKLETFORADDITIONALPRECAUTIONSANDUSEDIRECTIONSEPAReg.No.51036-429EPAEst.No.51036-GA-001AD081705NETCONTENTS:___BASELABELPage8ManufacturedbyMicroFloCompanyLLCP.O.Box772099Memphis,TN38117

### Micro Flo Company LLC P.O. Box 772099 Memphis, TN 38117

PRODUCT NAME: Thidiazuron-Diuron EC EPA File Symbol: 51036-429

DATA WAIVER REQUEST

OPPTS Guideline 830.6319 The purpose of this test is to obtain information and determine the miscibility for a product. This test is intended to determine whether a pesticide solution is suitable for application after dilution with oil or other nonpolar solvents, where applicable, instead of water.

Thidiazuron-Diuron EC is made up with emulsifiers that work only when diluted in water. The label for this product is written to limit the application of 

### this product in water and/or tank mixes with water.

For this reason we are requesting a waiver of this data requirement.

Reference:



## Product Proper/ies Test Guide/ines: OPPTS 830.1000, Background for Product Proper/ies Test Guidelines; EPA 712-C-96-310. August 1996

MFC Waiver 51 036-432 (830.6319) 

## 1 ,**~** 

### , ' 

### , 

# .

, '

### Micro Flo Company LLC P.O. Box 772099 Memphis, TN 38117

PRODUCT NAME: Thidiazuron-Diuron EC EPA File Symbol: 51036-429

DATA WAIVER REQUEST

OPPTS Guideline 830.6321 The purpose of this test is to determine the potential for hazard when the pesticide product is used on or in the vicinity of electrical equipment and electrical conduits. Data is required when the end-use product is a nonconductant liquid and is to be used around electrical equipment.

Thidiazuron-Diuron EC is formulated with nonconductant solvents. but it is not designed to be used around electrical equipment or electrical conduits. Thidiazuron-Diuron EC is a cotton harvest aide and is not labeled for use around electrical equipment of electrical conduits.



## For this reason we are requesting a waiver of this data requirement.

Reference:



## Product Properties Test 

## Guidelines: OPPTS 830.1000, Background for Product Properties Test Guidelines; EPA 712-C-96-310, August 1996

MFC 

### Waiver 51 036·432 (830.6321) 

## 1

# MATERIAL TO BE ADDED TO JACKET

REG 

# #



# Description:

if 

# applicable, check all that are attached



# new stamped accepted label 

# en**~** .

# ~.

.. 0.

. 

# new CSF

.. 

# - D 

# 1°

.. ···0.·. notification 

# en· 

# D (') '.



# Instructions:
Attach this sheet to the top of ALL 

## material sent to the file room (both loose paper and

new material in jackets). This sheet will be imaged; a clear description will aid in finding material in the e-jacket Remove staples from all material. If returning loose paper then hold together with a binder or paper clip. CSFs should be placed in the CSF folder (if returning jacket) or covered with a red CBI sheet (if returning loose paper). Material to be returned to file room should be place in the appropriate bin.

Reviewer's Name:

Phone: 

# ..**~** 

## Date:

# ~cP+/-,,(~S'+4-,,')'-,L)'--_

Division: 

# 6'1UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON. D.C. 20460



## AUG 1 5 2007

Arysta LifeScience North America Corporation 15401 Weston Parkway, Suite 150 Cary, NC 27513 OFFICE OF PREVENTION. PESTICIOES AND TOXIC SUBSTANCES



### Subject: EPA Reg. # 66330-333 

### I Thidiazuron-Diuron EC Cotton Defoliant Diuron Reregistration

The amended label for EPA Reg. 66330-333 / Thidiazuron-Diuron EC Cotton Defoliant is acceptable provided the following changes are made to the label:

1. The order of the First Aid sections should be "If In Eyes, If on Skin or Clothing, If Inhaled, and If Swallowed".

2. The Note to Physician should be revised to address eye initation concerns.

3. Change the Hazards to Humans and Domestic Animals statements to "Corrosive. Causes irreversible eye damage. Causes skin initation. Do not get in eyes, on skin, or on clothing.".

4. Change the PPE statements to "Some materials that are chemical-resistant to this product

are made ofbanier laminate or butyl rubber. If you want more options, follow the instructions for category C on an EPA chemical-resistance selection chart. All pilots and flaggers must wear: Long-sleeved shirt and long pants, Shoes and socks. All mixers, loaders, other applicators, and other handlers must wear: Coveralls over short-sleeved shirt and short pants, Socks plus chemical-resistant footwear, Chemical-resistant gloves, Googles, face shield or glasses, Chemical-resistant apron when mixing, loading or cleaning equipment or spills, and Chemical-resistant headgear for overhead exposure. In addition to the PPE above, all handlers except for ground boom applicators, pilOts, and fiaggers must also wear a NIOSH approved particulate filtering respirator equipped with N, R, or P class filter media. The respirator should have a NIOSH approval number prefix TC-84A. It 

### is recommended that you require that the respirator wearer be fit tested, and trained in the use, maintenance, and limitations of the respirator." to comply with the Diuron RED.

5. On page 2, after "Keep and wash PPE separately from other laundry" add "Discard clothing and other absorbent materials that have been drenched or heavily contaminated with this product's concentrate. Do not reuse them." to comply with the Diuron RED.

6. To the Application Instructions section, add "Apply a maximum oftwo applications per year. Minimum retreatment interval is 21 days.".

7. Change the Environmental Hazards statements to "Do not apply directly to water, or to

### areas where surface water is present or to intertidal areas below the mean high water mark. Do not contaminate water when disposing of equipment washwater or rinsate." ''This product may contaminate water through drift of spray in wind. This product has a high potential for runoff for several months or more after application. Poorly draining soils and soils with shallow water tables are more prone to produce runoff that contains this product. A level, well-maintained vegetative buffer strip between areas to which this product is applied and surface water features such as ponds, streams, and springs will reduce the potential for contamination of water from runoff. Runoff of this product will be reduced by avoiding applications when rainfall is forecasted to occur within 48 hours. Sound erosion control practices will reduce this product's contribution to surface water contamination!' "This chemical has properties and characteristics associated with chemicals detected in ground water. Use of this chemical in areas where soils are permeable, particularly where the water table is shallow, may result in groundwater contamination." to comply with the Thidiazuron RED.

8. To the Conditions of Sale change "Arysta disclaims all" to "To the extent consistent with applicable law, Arysta disclaims all "and "To the extent permitted by law" to "To the
extent consistent with applicable law".

9. Change the REI to "24 hours" to comply with the Thidiazuron RED.

10. To the Procedures to 

### Lower Spray Drift Potential onto Non Target Crops section delete "Do not apply this product by ground within 100 feet or by air within O.S 

### mile of lettuce" and add "Thidiazuron products can not be applied by air within ;h 

### mile oflettuce or S 

### miles downwind of the point of application when citrus is in flush (burst of new growth,

as in springtime) in the Rio Grande valley of Texas. Ground applications are restricted to 100 feet away from lettuce and**~** 

### mile downwind from the point of application for citrus. (In general, a decrease in droplet size or increase in wind speed at the time of application will result in risk to non-target organisms. Alternatively, if droplet size is coarser or wind speeds are lower, exposures due to drift would be reduced)." to the Rio Grande Valley of Texas Procedures to Lower Spray 

### Drift Potential section to comply with the Thidiazuron RED.

11. To the Application Rate Table under the heading ail 

### A change 0.075 to 0.05, 0.1 to 0.07, 0.15 to 0.1, and 0.1875 to 

### 0.125.

If you have any questions please call Erik Kraft at 703-308-9358.

Sincerely,

Joanne Miller Product Manager 23 Herbicide Branch Registration Division (7S0SP)

# THIDIAZURON-DIURON EC

COTTON DEFOLIANT

For Agricultural Use Only 

## ACCEPTED with COMMENTS In EPA Letter D2ted: 

## AUG 1 5 2007

Under the Federal tnseclicide, FlIllgicide, and RodentiddeAct



### as Ilmended, 

### for the pesticide registered 

### under EPA 

### Reg. No.



# {U30-333

ACTIVE INGREDIENTS: Thidiazuron: N-phenyl-N' 1.2,3-1hidiazol-5-ylurea"", Diuron: 3-(3,4-dichlorophenyl)-1, 1-dimethylurea*

.. 

### ............... 12%



### . ....... 6% OTHER INGREDIENTS:.



### . ....... 82%



## , 

# I TOTAL 100%

Contains 1 lb. Thidiazuron per gallon and 0.5 lb. Diuron per gallon

KEEP OUT OF REACH OF CHILDREN 

## DANGER

- PELIGRO
51 usted no entiende la etiqueta, busque a alguien para que se fa explique a usted en detalle. (If you do not understand this label, find someone to explain it to you in detail.)

FIRST AID 

## IF ON SKIN 

## OR 

## • Take off contaminated clothing. CLOTHING: 

## • Rinse skin immediately with plenty of water for 15-20 minutes.



## • Call a poison control center or doctor for treatmenl advice. IF IN EYES: 

## • Hold eye open and rinse slowly and gently with waler for 15-20 minutes.



## • Remove conlact lenses, if presenl, after Ihe first 5 minules, then continue rinsing.



## • Call a poison control center or doctor for Ireatment advice. 

## IF INHALED, 

## • Move person to fresh air.



## • If person is nol breathing, call 

### 911 or an ambulance, then give artificial respiration, preferably mouth-to-mouth is possible.



## • Call a poison conlrol center or doctor for trealmenl advice. IF SWALLOWED: 

### , Immediately call a poison control center or doclor for treatment advice. 

### • 

## • Do not induce vomiting unless told to do so by a poison conlrol center or doctor.



### • Have person sip a glass or waler if able to swallow. 

# I· Do not qive anythinq by moulh to an unconscious person NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate the use of gastric lavage,

HOT LINE NUMBER Have the product container or label with you when calling a pOison control center or doctor

I or 'going for treatment. 

# I

EMERGENCY NUMBERS: 

# J

• Transportation or spill, call CHEMTREC 800·424-9300. 

# l

____ , ___ H_u_m_a_n_a_n_d_A

__

n_im

__

'I_h_e_a_l_th_,_B_S_S_-3_0_3_-S_9_5_2

________________________________ __

SEE INSIDE (SIDE PANEL) FOR ADDITIONAL PRECAUTIONS AND USE DIRECTIONS

EPA Reg. No. 66330-333 

## AD XXXXXX EPA Est. No. 51036·Gh·001 NET CONTt:fIIl S.

______ __

Manufactured for Arysta UfeScience North America Corporation 15401 Weston Parkway, Suite 150 Cary. NC 27513PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS AND DOMESTIC ANIMALS DANGER Corrosive. Causes irreversible eye damage. Causes burns. Harmful if inhaled. Do nol get in eyes, on skin, or on clothing. Avoid breathing dust or spray mist. Prolonged or frequently repeated skin-contact may cause allergic reactions in some individuals.

PERSONAL PROTECTIVE EQUIPMENT SomE! materials thai are chemical-resistant to this producl are barrier laminate or butyl rubber gloves. If you want more options, follow the instructions for category C on an EPA chemical-resistance category selection chart. All pilots, flaggers, and groundboom applicators must wear:

• Long-sleeved shirt and long pants and,

• Shoes plus socks All mixers, loaders, other applicators, and other handlers must wear:

• Long-sleeved shirl and long panls,

• Shoes plus socks,

• Chemical resistanl gloves, such as barrier laminate or butyl rubber gloves • A NIOSH-approved dusUmisl fillering respirator with any N 2

, R, P or HE filter or an NIOSH-approved dusUmist filtering respirator with approval number prefix TC-21 C.

• Chemical-resistant apron when mixing, loading, or cleaning equipment or spills Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables exist, use detergent and hot water. Keep and wa.sh PPE separately from other laundry.

ENGINEERING CONTROLS STATEMENT Pilots must use an enclosed cockpit that meets the requirements, listed in the Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)]. Flaggers supporting aerial applications must use an enclosed cab that meets the definition in the Worker Protection Standard for Agricultural Pesticides 140 CFR 170.240(d)(5)] for dermal protection. In addition, flaggers must wear long-sleeved shirt, long pants, shoes, and socks.

USER SAFETY RECOMMENDATIONS Users shoutd:



### •

• Wash hands thoroughly with soap and water after handling and before eating, drinking, chewing gum, using tobacco, or using the toHet.

• Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on clean clothing.

e Remove PPE immediately after handling this product. Wash the outside of gloves before removing As soon as possible, wash thoroughly and change ·Into clean cloth·lng.

ENVIRONMENTAL HAZARDS For terrestrial uses, do not appty directly to water, or to areas where surface water is present, or to Intertidal areas below the mean high water mark, except as specified on this label for application to rice Do not contaminate water when disposing of equipment wash waters. Apply this product only as specified on thiS labelSTORAGE AND DISPOSAL Do not contaminate water, food, or feed by storage or disposal.

PESTICIDE STORAGE: Store this product in a cool, dry place in its original container only. Container should be closed when not in use. Do not expose the product to open flame excessive heat. Store in original container and keep closed.

PESTICtDE DISPOSAL: Pesticide wastes are acutely hazardous. Improper disposal of excess

i pesticide, spray mixture, or rinsate is a violation of Federal law. tf these wastes cannot be disposed of 

# I

by use according 10 label instructions, contact your State Pesticide or Environmental Control Agency, or the Hazardous Waste representative at the nearest EPA Regional Office for guidance. 

# i I CONTAINER DISPOSAL: Triple rinse (or equivalent); then offer for recycling or reconditioning, or

puncture and dispose of in sanitary landfill, or by other procedures approved by State and local authorities. DO NOT REUSE EMPTY CONTAINER

PHYStCAL OR CHEMICAL HAZARDS Do not use or store near heat or open flame. To Contain a Spilt: Absorb liquid by covering it with cat litter, commercial clay, lime, sand, sawdust, or soda ash. Once absorbed, bury the cleaning materiats and cleanse the spill area with a detergent and water solution.

GENERAL INFORMATION THIDIAZURON-DIURON EC is a harvest aid for cotton, used for leaf removal prior to harvest. THIDIAZURON-DIURON EC can be applied in most weather conditions, both warm and cool.

USE PRECAUTIONS' This product ',S not to be applied through any type of irrigation system. Effecliveness of THIDIAZURON-DtURON EC will be reduced if rainfall occurs within 

### 12 hours post application. Foliage from treated plants or gin Irash is not to be fed to livestock.

Rotation to the fottowing crops requires the minimum specified application of THIDIAZURON-DIURON EC: small grains, sorghum, corn, or root crops (except carrots. onions) legumes (including alfal/a) or leafy vegetable (except lettuce)

. cote crops, garlic, safflower, tomatoes, and watermelon. carrots onions. cantaloupe, honeydew melon/casaba melon, muskmelon, or peppers tettuce. when soil has been deep-plowed 

### (12-15 inches).

OR lettuce when soil is only disced (4-6 inches) All other crops. periods below after the last

. two (2) months

.. two (2) months

. two (2) months .Ihree (3) months

four (4) months .flve (5) months

. two (2) months nine (9) months twelve 

### (12) months

Special Note for inter-cropped grains and legumes planted either as cover crops or planted Into treated fields before the minimum two (2) month plant back time after the final THIDtAZURON-DIURON EC application. Any such crops are prohibited for use as feed or food and may be used only as cover crops.

Do not use immature crops for food or feed.

Prevent spray drift from contacting crops other than mature cotton, since this product may defoliate or injure other plant species.

Mixtures 'NIH"": organoprlosphates can Increase nontarget crop phyiotoxlcliy ExerCise additional care wiler, lettuce, cl!rUs, cantaiClupes or any other edibie cro;:;s are ad}8cen; to THIDiAZURQhJ-uIURON EC t"eai9d cotlon fields

### PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL ONTO NONTARGET CROPS Under windy weather conditions, applications of**THIDIAZURON~DIURON** 

### EC may drift to non-target crops. The following procedures can help reduce the potential for drift:

.. If wind speeds top ten (10) miles per hour at the apptication site, do not make aerial or ground applications of THIDIAZURON-DIURON EC.

.. Nozzle pressure of 20-30 psi is recommended.

.. Do not apply this product during a temperature inversion because drift potentiat is high. In addition, do not appty this product if the development of a temperature inversion appears likely during the application period.

.. Do not apply this product by ground within 100 feet or by air within 0.5 mile of lettuce.

RIO GRANDE VALLEY OF TEXAS PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL The following procedures can help reduce the potential for drift:

.. tf wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground applications of THtDIAZURON-DIURON EC. If wind sp.eeds are less than ten (10) miles per hour, observe local recommendations from your State Extension Cotton Specialist.

.. Nozzle pressure of 20-30 psi is recommended.

.. Do not apply this product during a temperature inversion because drift potential is high. In addition, do not apply this product if the development of a temperature inversion appears likely during the application period.

.. Use the maximum nozzle orifice size that provides proper coverage and deposition of this product.

.. CITRUS AREAS: Do not apply this product by ground within 0.5 mile or by air within 5 miles downwind of citrus in flush.

DIRECTIONS FOR USE It is a viotation of Federal taw to use this product in a manner inconsistent with its labeling.

Do not apply this product in a way that will contact workers or other persons, either directty or through drift. Only protected handlers may be in the area during applicationAGRICULTURAL USE REQUIREMENTS Use this product only in accordance with its labeling and with the Worker Protection Standard, 

### 40 CFR Part 170. This Standard contains requirements for the protection of agricultural workers On farms, forests, nurseries, and greenhouses, and handlers of agricultural pesticides 

### tt contains requirements for training, decontamination, notification, and emergency assistance. It also contains specific instructions and exceptions pertaining to the statement on this label about personal protective equipment (PPE), and restricted-entry interval. The requirements in this box only apply to uses of this product that are covered by the Worker Protection Standard.

Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 

### 12 hours. For minimum early entry PPE use the following: PPE required for early entry to treated areas Ihat is permitted under the Worker Protection Standard and that involves contact with anything that has been treated, such as plants, soil, or water, is:

• Coveralls

• Shoes plus socks

• Chemical-resistant gloves made of any waterproof material



### •

SPRAY DRIFT Requirements for reducing spray drift for diuron ground and aerial applications: Use best practices to avoid drift to all other crops and non-target areas. Do not apply when conditions favor drift from target areas. The interaction of many equipment- and weather-related factors determine the potential for spray drifL Avoiding spray drift at the application site is the responsibility of the applicator. The applicator must follow the most restrictive precartions to avoid drift, inctuding those found in this labeling as well as applicable state and local regulations and ordinances. A drift control agent may reduce drift, however, it may also decrease weed control.

Make aerial or ground applications only when the wind speed is less than or equal to 10 miles per hour.

Do not make aerial or ground applications into temperature inversions.

Apply with medium or coarser spray (according to ASAE S1andard 

### 572) for standard nozzles.

Additional requirements for ground apptications: When applying to crops, apply w·lth nozzle height no more than 

### 2 feet above the ground or crop canopy. When applying to non-crop areas, use lowest nozzle height consistent with safety and efficacy. Direct
spray into target vegetation.

Additional requirements for aerial applications: The spray boom should be mounted on the aircraft so as to minimize drift caused by wing tip vortices. The boom iength must not exceed 

### 75% of the wingspan or 

### 90% of rotor blade diameter.

Use upwind swath displacement.

When applYing to crops, do not release spray al a height greaier than 

### 6 to 

### 10 feet above the ground or crop canopy. When applying to non-crOp areas, apply at a minimum safe altitude above the area being treated.

Do not apply by air if sensitive non-target crops are within 

### 100 feet of the application site.

TtME OF APPLICATiON TH!DIAZURON-DIURON EC defoliant applications are to be made only 011 mature cotton plants when the· uppermosl harvestable boll IS mature. Boll maturity is defined as I} when a boll is squeezed between thumb and finger. it does not dent. 2) when cutting a cross section with 8 shaep knife IS difficult; 3) when seeds In cross section lack**Iiq~lld** within the seed coat or outer edges of seed coai are light brown. and 4) when fully developed cotyledons a·,-e**p~e:,eni**Make appl'lcations of THIDIAZURON-DIURON EC at least 5 days prior to expected harvest date.

NOTE: Adequate defoliation with THIDIAZURON-DIURON EC depends on three factors:

• Cotton is actively growing.

• High retative humidity.

• Cotton plant teaves are turgid and not desiccated.

ATTENTION: Desiccation and/or leaf freezing may occur during periods of high temperature when adjuvants are added to THtOIAZURON-DIURON EC application solution. Products and adjuvants known to cause desiccation of cotton leaf tissue shoutd not be used.

Under low nighttime temperatures (below 60°F) or othervvise adverse conditions, this product, when used alone, may provide less than expected defoliation and / or regrowth·suppression.

APPLICATtON INFORMATION Use an adequate volume of water with the recommended amount of THtDIAZURON-DIURON EC defoliant to uniformly and completely cover leaves. For ground equipment, apply 10

- 25 gallon per acre and by air, use 2 -10 gallons per acre. Maintain agitation during application.

DOSAGE INFORMATION Application Rate: Before harvest, use 0.4-1.0 pints active ingred·lent/acre (6.4-16 fl. 

### oz.lA).

One gallon of THIDIAZURON-DIURON EC will treat 8 - 20 acres. Refer to the dose rate table below.

In some situations, a follow-up application may be needed. THIDtAZURON-DIURON EC may be used for this application. Other defoliants may be needed. If additional boll opening is required, Ethephon 6 may be used at recommended rates; see product label for rates and timings. Consult your local State Extension Cotton Specialist recommendations for rates and timings.

The maximum annual use rate of THIDIAZURON-DIURON EC is 16 oz. per acre per season

MIXtNG tNSTRUCTIONS 1. Filt spray applicator tank with at least one half of the water to be used 2. Start agitation 3 Add the appropriate volume of THIDIAZURON -DIU RON EC 4. Continue agitation and fili tank with the remainder of the water to be used 5 Agitation shoutd continue throughout the application

CALlFORNtA ONLY: PRECONDtTtONING When used as a pre-conditioner seven to ten days before application of this or other defoliant compounds, th·ls product will improve the efficacy of such a defoliant application Before use, observe all product label directions, recommendations and prohibitions on both product's labels.

Application Rate: Use 4-6 fl.oz. of this product/acre in an aerial application of 2-10 gallons of spray solution or ground application of 10-25 gallons of spray sotutionAPPLICATION RATE TABLE 

### for TH!DJAZURON DIURON EC



## - THJDJAZURON-DJURON EC One Gallon of THJDIAZURON. Active Ingredients per Acre Formulated Product DJURON EC Wi!! Treat 6,4 Qz.lAcre 20 Acres g..,g..:f-5 Ibs. ai/Acre (0.4 pUAcce) 

### O. {> 0;- 8.8oz./Acre 15 Acres 

# L g..,...w.lbs. Ai/Acre (0.55 ptJAcre) 

### '-' 07 12.8 oz./Acre 10 Acres O.1Slbs. AI/Acre (0.8 ptJAcce) 

### "', I 16.0 ozJAcre 8 Acres Q..,...ig..7.& Ibs. ai/Acre (1.0 ptJAcre) 

## o,n",- DO NOT APPLY MORE THAN 1.0 PINT OF THJDJAZURON·DJURON EG PER ACRE PER SEASON.

IMPORTANT CLEAN OUT !NSTRUCTIONS When applying THIDIAZURON-DJURON EC, a residue may form in application 

### equipment This residue

can best be flushed out of the spraying system by using a commercial tank cleaner when done while residue is still fresh and moist. DO NOT ALLOW EQUIPMENT TO DRY BEFORE CLEAN OUT. Consul! your State Extension Cotton Specialist for recommended tank cleaners and cleaning procedures.

Use tank cleaner and water immediately after application. Flush the entire system including nozzles. booms. application tanks. sumps, pumps. and transfer lines. Allowing the spray solution to dry in the application equipment can result in residues that are more difficult to remove. Dried residues are extremely difficult to remove. To remove such dried residues, fiJI the affected equipment to capacity with commercia! tank cleaner solution and let it remain for 7 days. Afterwards, the equipment will need to be thoroughly flushed and rinsed.

Spray application equipment that has been inadequately cleaned will contain residue of THIDIAZURON

- DIURON EC. Such improper cleaning could lead to crop damage in later applications.

Arysta UfeScience North America Corporation assumes no !iability due to equipment that has not been properly cleaned.

CONDITIONS OF SALE

Arysta LifeScience North America Corporation C'Arysta") warrants that thiS product conforms to the chemical description on the label and is reasonably fit for the purposes stated on the label only when used in accordance with the directions under normal conditions of use. 2. This warranty does not extend to the use of this product contrary to label instructions. or under abnormal use conditions. or under conditions not reasonably foreseeable to Arysta. ARYST A D!SCLAIMS ALL OTHER WARRANTIES, EXPRESSED OR IMPLIED, INCLUDING ANY WARRANTY OF F!TNESS FOR A PARTICULAR PURPOSE OR MERCHANTAB!L1TY. TO THE EXTENT PERM!TTED BY LAW, SELLER SHALL NOT BE LIABLE FOR CONSEQUENTIAL, SPECIAL OR !NDIRECT DAMAGES RESULTING FROM OR IN CONNECTION WITH THE MANUFACTURE, SALE, DELIVERY, USE, HANDLING OR STORAGE OF THIS PRODUCT. TO THE EXTENT PERMITTED BY LAW, SELLER'S LIABILITY SHALL BE LIMITED TO THE REFUND OF THE PURCHASE PRICE. ARYSTA DOES NOT AUTHORtZE ANY AGENT OR REPRESENTAT!VE TO MAKE ANY OTHER WARRANTY, GUARANTEE OR REPRESENTATION CONCERN!NG THIS PRODUCT. 3. Critical and unforeseeable factors beyond the control of Arysta prevent Arysta from el"lminatlng all risks in connection with the use of thiS product. Such risks Include, but are no!·llmiied to. damage to plants and crops to which product IS applied, lack of complete con!rol, and damage caused by dnft to other plants or cmps. Such risks occur even though the product is reasonably fit for the use stated on the label and even though label directions are followed Except as staled In 1 above. to the extent perml!(ed by law, by purchasing, accepting and using th:s product, the buyer and user acknowledge and assume all risks and liabilities tesulting from handling, storage. and use of to IS productTHIDIAZURON-DIURONEGCOTTONDEFOLIANTForAgriculturalUseOnly/\(:JIVEINGREDtENTS:Thirtiazuron:N-phenyl-N'-1,2,3-thidiazol-5-ylurea·,n",r()<13-f3.4-dlclllorophenylj--'l,t·dlmethylurea*__t2%6%82%tOO%OHlerIngredients:TOTAL(:",,1'_1111"III)TtTidiazuronpergalionand0Sib,DiuronpergallonKEEPOUTOFREACHOFCHILDRENDANGER-PELIGRO::-,USl'2dnoenl;endetaeliqueta,busqueaalgu'lenparaqueselaexptiqueausted,,"\if!!;"le,1,Ifyoudonotunderstandthislabel,findSomeonetoexplainittoyouindetaiL)I,rtf{IFreLOIFt;1>-1irSII.'"I!I"'"!TAID.jSKINORTakeoffcontalllinatedcloUTing,TI-IING:Rinseskinimmediatelywithplentyofwaterfort5-20minutes___M__'_'__,,_CaliaEoisoncontrolcenterordoctorfortreatmentadvice_EYESHoldeyeopenandrinseslowlyandgentlywithwaterfor15·20minutesReillovecontactlenses,ifpresent,afterthefirst5minutes,thencontinuE'rinSlflg_Calla20isoncontrolcenter.ordoctorfortreatmentadvice,'HALED:Movepersontofreshair.ItpersonisnotbreatiTing,call9t 1oranambulance,Ihengiveartificialrespiration,preferablymouth-to-mouthispossible.Callaeoisoncontrolcenterordoclo!fortreatmentadvice_NALLOWED:Immediatelycallapoisoncontrolcenterordoctorfortreatmentadv'lceDonotinducevomitingunlesstoldtodosobyOJpoisoncontrolcenterordoctor_rtavepersonsipaglassorwaterIfabletoswallow•DonotgiveanythingbymouthtoanunconsciousQ€rson.'E"'TO--PHYSIClAN:'Probablemucosaldamagemaycontraindicatetheuseof'rir.bV<loe.---------.-"----------.::iCiTLINENUMBERpd'-;;:-t1ro'dllctco'ntalnerorlabelwithyouwhencallingapoisoncontrolcenterI1-1"Il'T,--:-,0<:101'orgoingfortreatment.:eMI!ERGENCYNUMBERS:Transportationorspill,cattCHEMTREC800-424-9300.An.ilna!...i:.eatth,8_66-303-6952101,,,,,,,,11",(',11>""".1)""""P'U.T)·RI:I)(12!)5U7)PRECAUTIONARYSTATEMENTSHAZARDSTOHUMANSANDDOMESTICANtMALSDANGERCorrosive,Causesirreversibleeyedamage.Causesburns.HarmfUlifinhaled.Donotgetineyes,onskin,oronclothing_AvoidbreathingdustorspraymistProlongedorfrequentlyrepeatedskin-contactmaycauseallergicreactionsinsomeindividuals.ENVIRONMENTAL,.HAZARDSForterrestrialuses,donotapplydirectlytowater,ortoareaswheresurfacewaterispresent.ortointertidalareasbelowthemeanhighwatermark,exceptasspecifiedonthislabelforapplicationtorice.Donotcontaminatewaterwhendisposingofequipmentwashwaters.Applythisproductonlyasspecifiedonthislabel.STORAGEANDDISPOSALDonotcontaminatewater,food,orfeedbystorageordisposal.PESTtCtDESTORAGE;Storethisproductinacool,dryplaceinitsoriginalcontaineronly_Containershouldbeclosedwhennotinuse,Donotexposetheproducttoopenflameexcessiveheat.Storeinoriginalcontainerandkeepclosed.PESTtCtDEDtSPOSALPesticidewastesareacutelyhazardous.Improperdisposalofexcesspesticide,spraymixture.orrinsateisaviolationofFederallaw.IfthesewastescaQnotbedisposedofbyuseaccordingtolabelinstructions.contactyourStatePesticideorEnvironmentalControlAgency,ortr,eHazardousWasterepresentativeatthenearestEPARegionalOfficeforguidance,CONTAINERDtSPOSAL:Triplerinse(orequivalent);thenofferforrecyclingorreconditioning,orpunctureanddisposeofinsanitarylandfill,orbyotherproceduresapprovedbyStateandlocalauthorities.DONOTREUSEEMPTYCONTAINERPHYStCALORCHEMICALHAZARDSDonotuseorstorenearheatoropenfiame_ToContainaSpilt;Absorbliquidbycoveringitwithcatlitter,commercialclay,lime,sand,sawdust,orsodaash_Onceabsorbed,burythecleaningmaterialsandcleansethespillareawithadetergentandwatersolution_DtRECTlONSFORUSEItisaviotationofFederatlawtousethisproductinamanner'Iflcons'lstentwithitslabeting.SEEATTACHEDBOOKLETFORADDITIONALPRECAUTIONSANDUSEDIRECTIONSEPAReg.No.66330-333EPAEst.No.51036-GA.(l01ADxxxxxxNETCONTENTS:BASELABELPage8ManufacturedforArystaUfeScienceNorthAmericaCorporation15401WestonParkway,Suite150Cary,NC27513

### July 13, 2007 

### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF
PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES



### MEMORANDUM:

Subject:

From:

Through:

To: 

## DiuronRED Thidiazuron-Diuron EC Cotton Defoliant EPA Reg. No.: 66330-333 Re: PRE Preliminary Label Assessment

Judy Loranger

# ~**-i..D~** 

# e-J

Product Reregistration Branch Special Review and Reregistration Division (7508P)

Lawrence Schnaubelt 

# .("*"'-**g~';:f2~?** Product Reregistration Branch Special Review and Reregistration Division (7508P)

Joanne Miller, Product Manager 23 Herbicide Branch Registration Division (7505P)

### SCOPE: The primary purpose of this preliminary label assessment is to determine whether or not the draft labels submitted in connection with product reregistration comply with amended labeling language specified in Chapter V of the subject REDIIRED. Product-specific data (product chemistry, acute toxicity, and in some cases efficacy data) were also required to be submitted or cited to support product reregistration. PRB's reviews of these data are appended to this assessment and may require additional revisions to the product label.

BACKGROUND: The registrant has submitted 5 copies of draft labeling for the subject product in its 8-month response to the REDIIRED. PRB has completed a preliminary
assessment of the draft labeling. A copy of this assessment may be accessed electronically on the LAN through the Q-Drive. The path is q:lprbllabeII066330/333.

Note: In 

### addition to the information presented in this preliminary label assessment, Product ManagerlLabel Reviewers must apply their own knowledge ofthe subject product and the product's regulatory history (including comparison with existing stamped accepted labeling) to conduct a final review of the proposed labeL It 

### is the responsibility of the PM to obtain the necessary label improvements required for final product reregistration.

Please note that this product contains multiple active ingredients. Additionallabel reviews will be necessary when the RED is issued for the other active ingredient (Thidiazuron.)

PRB reconunends that the PMs continue to follow the guidance provided in the Label Review Manual, including formatting suggestions presented in the sample labels in Chapter 3, to improve the quality and consistency of product labels.



## RECOMMENDATIONS:

The subject product requires revisions to conform with the RED and acute toxicity review. Deficiencies are listed in the table below. Once these revisions have been submitted and approved by the PM, the PM may issue an amended registration. Since this product contains multiple active ingredients it may not be reregistered until a favorable registration eligibility decision is made for all active ingredients. At that time the more restrictive language must be adopted for the labeL



### 2

### Appendix I

PRB Label Analysis For Compliance With Label Revisions Specified In the 

## REDIIRED and/or 

## Technical Reviews

Label Requirement Acceptable Not Acceptable Comments Restricted Use Pesticide Per the acute toxicity review, this product meets the criterion for restricted

use classification based on data that place 

### it in toxicity category I for eye irritation. Ingredients Statement X Signal Word X
First Aid X Based on toxicity ranking noted in the
acute toxicity review, 

### PRB recommends that the First Aid statements be placed

on the label in the following order:



### "IF IN EYES

... IF ON SKIN OR CLOTHING

... IF INHALED

... 

### IF SWALLOWED.,. 

### " Emergency Information X
Note to Physician X PRB recommends that the Note to Physician be revised to address eye irritation concerns. Hazards to Humans and X Per the acute toxicity review, the Domestic Animals Hazards to Humans and Domestic Animals must be revised to read:

"DANGER Corrosive. Causes irreversible eye damage. Causes skin irritation. Do not get 

### in eyes, on skin, or on clothing."
PPE X Per the acute toxicity review and the Diuron RED, and Page 10- l6 of the label review manual, the PPE section must be revised to read:

"Some materials that are chemicalresistant to this product are made of barrier laminate or butyl rubber. If you want more options, follow the instructions for category C on an EPA chemical-resistance selection chart.

All pilots and flaggers must wear: Long-sleeved shirt and long pants, Shoes and socks.

All mixers, loaders, other applicators and other handlers must wear:



## 3

### Label Requirement Acceptable Not Acceptable Comments

Coveralls over**short~sleeved** 

### shirt and short pants, Socks plus**chemical~resistant** 

### footwear,**Chemical~resistant** 

### gloves, Goggles, face sbield or safety glasses,**Chemical~resistant** 

### apron when mixing, loading or cleaning equipment or spills, 

### ,nd Chemical-resistant headgear for overhead exposure. In addition to the PPE above, all handlers except for ground boom applicators, pilots and flaggers must also

wear a**NIOSH~approved** 

### dust/mist filtering respirator with any N, R, P of HE filter or a NIOSH-approved dust/mist filtering respirator with approval number TC-2IC."

Note to PM: The PPE specified in the RED has been revised as required in the acute toxicity review and the label review manual to require double layer PPE plus eyewear for aU handlers including ground boom applicators. Engineering Controls 

### X
User Safety X 

### Because coveralls are required for some Requirements handlers PRB recommends that the following text be added to the User Safety Requirements:

"Discard clothing and other absorbent materials that have been drenched or heavily contaminated with this product's
concentrate. Do not reuse them." User Safety X 

### Recommendations Environmental Hazards X 

### The phrase "For terrestrial Use" erroneously appearing on Page 5 of the Diuron RED label table and also on the label is confusing and should be deleted from the label. Physical and Chemical X 

### Hazards WPS text X 

### Non-WPS text 

### NlA Storage and Disposal X**~ay** 

### Drift Labeling X 

### General Precautions and X 

### Restrictions Application Instructions Per Page 12 of the Diuron RED, the following text was required for use on



### 4

### Label Requirement Acceptable Not Acceptable Comments

cotton:

"Apply a maximum of three applications
per year."

Minimum retreatment interval is 21 days."

Note to PM: PRE is uncertain whether these restrictions are appropriate/needed for this pre-harvest defoliant use and defers to RD re.garding this issue. Other Comments 

### NiA



### 5

### UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

Subject:

From:

To:

Applicunt:**FI~bruary** 

### 21, 2007



### EPA Reg. No.:**66330-33!Thidiazuron~Diurol1** 

### EC DP Barcode: 

### 336474 

### Case No.: 004(1**,,~\** 

### lvlarianne Lewis, Biologist " ,



# . , 

# , Product Reregistration Branch j
< •• 

### l \ i**lL')~"'-** 

### 1--' '

... , 

### Special Review and Reregistration Division (7508e)



### Barbara Briscoe, CRM 

### Product Reregistration Branch $pecial Review and Reregistration Division (7508C)



### Arysta LifeScicnce North America Corp. 15401 Weston Parkway, Suite 150 

### Cary, NC 27513

FORMULATION FROM EPA Reg. No. 

### 66330·33 LABEL:

Ac,:Jive Ingredien!(s): Diuron

. < ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 

### Thidiazuron

.................. . Jnert lngredient(s):

. Total OFFICE OF PREVENTION, PESTICIDES AND TOXIC SUI)STANCES



### 6.0% 12.0%**_82.0~'{)** 

### 100.0%

### BACKORQllND: In the 8 month re:.pOllse to the Diuron RED, the registrant has submitted acute toxicity studies to support the reregistration of their product, EPA 

### Reg. No. 66330-33. 

### The MRlD's are as [oHows: 468773-03 (81-1),468773-04 (81-2), 468773-05 (81-3), 468773-06 (81- 4), 468773-07 (81-5), 468773-08 (81-6). The studies were conducted by Product Safety Labs. The test material used in each of the studies was the subject product.

The primary eye ilTit3tion study (81-4) is self validated as Toxicity Category I therefore a fuli review of this 

### study wiiJ Hot be conducted at this time by 

### the Agency.

" Five (8 I-I, 81-2, 8 j 

### -3, 81-5, 81-6) of the acute toxicity**studi~s** 

### submitted are acceptable to 

### suppori the reregistration of EPA**R~~g.** 

### No. 66330-33.

{t 

### The primary eye in'itation study (81-4) is self validated as Toxicity Category L

The acute toxicity profile for EPA 

### Reg. No. 66330-33 

### is currently:

Acote On:! Acute I)ermal Aeutc Inhal8tion Pri mary 

### Eye Primal',';' Dennal Skin Sensitization 

### IV IV )V

11 

### Hon sensitizer Accept,'lbie Acceptable**Acc~ptable** 

### SclfValidated Acceptable Acceptable

NOTE: 

### Tile acute tl.lxicity requirements have been satisficd for the subject product.

### DATA REVIEW FOR ACUTE ORAL TOXICITY (§8!-1, 870.!lOO)

Reviewer: Marianne Lc\vis Product lVlanager: Jim Tompkins, 25 MRID No.: 468773-03 Study Completion Date: 511 5/06 

### Report No.: 19086

Testing Facility: Product Safety Labs Author: G. Moore

Quality Assurance (40 CFR**~160.12):** 

### Included

Test Material: Thidiazuron-Diuron 

### Ee, amber liquid

Species: 

### SpragueMDawley derived albino rat Age: young adult 

### Weight', females::::: 194

-- 233 

### Source: Ace Animals, Inc.

Conclusion: Up & 

### Down Method

1. 

### LDso (mg/kg): > 

### 5000 

### Jnr/kg

2. Toxicity Category: lV 

### Classification: Acceptable

Procedure- (Deviations from**§81~1):** 

### none

Results:

.. 

### Animalld Dose Level 

### Short 

### tem1 (mg/kg) 

### outcome 

## ._---- 8256 5000 S ---'--' 

## 8282 5000 S 

# ._- 8283 5000 S

.. 

### Long tenn

outcome 

### S S
S



### Observations: 

## 3/3 piloerection, li3 hypoactive, 113 ano-genital staining, all active and healthy from 

### day 3 to 

### end of study.



### Gross Necropsy: No observabie abnonnalities noted 

# -

### DATA REVIEW FOR ACUTE DERMAL TOX1ClTY (§81-2, 870.1100)

Product ]\tlanager: Jim Tompkins, 25 MRlD No.: 468773-04

Testing Facility: Product Safety Labs Authow: G. Moore



### Quality Assurance (40 CFR §160.12): Included Reviewer: Marianne Lewis 

### Study Completion Date: 

### 5115/06 Report No.: 19087

Test IVlatcria!: Thidiazuron-Diuron 

## Ee, amber liquid 

### Species: Sprague-Dawley derived albino rat Weight: males**~~** 

### 328

- 343 g; females = 

### 218

- 230 g Age: 

### young adult Sour'C\i; ACe Animals, lnc.



### Summary:

1. LD 5 () 

### (mglkg): > 5000 llIg1kg



### 2. Tnxki!y 

### Categury: IV 

### Classification: Acceptable

Procedure (Dcvi'Htions From §8J-2): none

Results; 

## IF Reported Mortathy**"~- ~--~~--~~~~~~~~-.~~~~~~~~**  

# I (number deaths/number tested) DOSAGE (mg!kg)**~ -L_~es**  

### Females Combined 

## 5000

.

## --~+I=-~~~~O~/~5~~~~~~~0~15-=~~9-~~~O~/~IO~~~~

Observations: Twenty four hours prior to application of the test material the dorsal area and tnmki; were clipped free of hair. The neat test lO<lterial was applied evenly over a dose area of

approx. 2 x 3 inches (approx. 10%, of total body surface) and covered with 2 x 3 inch 4-ply gauze pad.**Th~** 

### pads and trunks were wrapped with a 3 inch Durapore tape. After 24 hours, the wraps and pads were removed and the test sites were gently cleansed.

1 Oil 

### 0 exhibited erythema &" 

### edema, 7/10 desquamation (lasting throughout the study)

- apart from these signs all appeared active and healthy for the duration of the study.

Gross Necropsy Findings: No observable abnonnalities were noted.

### DATA REVIEW FOR ACUTE INHALATION TOXICITY TESTING (§81-3, 870.1300)

Product Manager: Jim Tompkins, 25
MRID No.: 468773-05 Reviewer: Marianne Lewis Study Completion Date; 51] S!06 

### Report No.: 19088

Testing Facility: Product Safety Labs Author: O. Moore

Quality Assurance (40 CFR §160.12): Included

Test Material: Thidiazurou-Diuron 

## Ee, amber liquid

Species: Sprague-Dawley derived albino rat 

### \Veight: males = 

### 316

- 326 g; females = 

### 209

- 244 g Age: young adult 

### Source: Ace Animals, Inc.

Summary:

1. LCSII (mg/L): > 

### 2.01 mg/L

2, MMAD: 3.0 I-Lm 

### GSD: 1.75



### 3, Tox, Category: ,IV 

### Classification: Acceptable

Proc£di1r€ (Deviation From §81-3): none

Results: Reported Mortality

## r-EXp~-SUfe-- 

# l--- number deaths/number 

### tested) 

# I**Concentr~ion_** Males

____ 

### .Fema_les 

## -f_-oo-mblned 

## 1--

__ 0 

### 52..'.'.'l¥i·3 0/5"--__**~** 

### _ 1

__ 

### "2,,,.01 rng/l 2/5 

# j

__ 1/5

# ~3"-1 .. IO",-

__ --,**----~--** 

## Chamber Atmosphere**~~b-evel** 

## nw/L MMAD 

# +--- GSD

-- 0.52 

### 2.8 11m 1.75 2.9**~m** 

### 1.75



## --- 2.01 

### 2.9**~m** 

### 1.72 3.0**~111** 

### 1.75



### -

### - -----;;- 

### Chamber Dose Level m.g/L Dose Level**mgl~** 

### Environment O.S? 

### 2.01**------,-~,** 

### - Chamber Volume 

### 150 L ISO L

- Airflow 

### 45.7 45.7

T 

### f'C) 

### 21

- 22 ? 

### 1 - ,,)

i 

### emDeraturc \ -**--~-**

# ~2**-7~** 

# -:::j Relative**HUl11i~** 

### % 42

- 68



### Clinical Observations:



### iD(?sc mgll. 

# I**Tim'~-~)fDeath** 

### Clinical Observations**-.~---** 

# J**~52_J** ____

# N_I_~___**~~~l\~egf~~:~ r~~~i~at~O;~:~f:~~~;** **hwoacti~'e,** all active and 

# I

I 2.01 

# I 3/] 0 on 

### day 2 Reduced fecal volume, hunched posture, hypo activity, irregular 

# l I I respiration, moist rales, facial staining, red ocular discharge, 6/10 

### d 

# I L_.

_____ 

# ,._"._L

____**~~;s_'_fu_'_:t~~~~Lo_rS_)_IO_s_t_w_e_ight** during first half O_f_st_U_d_Y,_-_a_I_1 _ga_in_e_d b_y_en_d_.

Gross Necmpsy Findings:

## ~EQ~~~~lg/L_I**Gr~~.~** Necropsy Observations

. 

## 1--

## O.5~o observable abnOimalities noted.

# --2~(il 

# I**~~'~cden1.s:** lungs slight 

### edema, red intestines; survivors: 

### no observable



### . __**~** 

### __ .....L abno"nTI=al"it"ie"'sc,I"'10"t"cd"--

_____________________ _

### DATA REVIEW FOR SKIN IRRITATION TESTING (§81-5, 870.2500)

Product Manager: Jim Tompkins, 25
MRID No.: 468773-07

Testing Facility: Product Safety Labs Author: 

### G. Moore



### Quality Assurance (40 CFR §160.12): Included Reviewer: Marianne Lewis Study Completion Date: 

### 5115106 Report No.: 19090

Test Material:**Thidiazuron~Diuron** 

## Ee, amber liquid

Dosage: Species: Age: 

### Sex: Weight: 

### Source:

Smnmary: 0.5 

### mL 

### New Zealand albino rabbit
young adult
3 males


### not given Robinson Services, Inc.

1. 

### Toxidty Category: II



### 2. Classification: Acceptable**Prm;~dure** 

### (Deviations From §81-S): none PI! = 

### 3.8

Results: Twenty four hours prior to application ofihe test material the dorsal area and trunks

were dipped free of hair. The test material was applied to one 6**cm~** 

### intact dose site and covered with a I x I inch 4-ply gauze pad and wrapped with 3 inch Micropore tape. After 4 hours the pnds and wrappings were removed and the test sites were cleansed.

At I hr., 

### 113 very slight erythema, 2/3 well defined erythema, & 

### 3/3 very slight edema. From 24

to 48 hrs., 

### 2/3 well defined erythema, 

### 1/3 moderate to 

### severe erythema, & 

### 3/3 slight edema. At 72 hrs., 3/3 well defined erythema, 3/3 slight edema, & 

### 2/3 hyperkeratosis. On day 

### 7,313 very slight erythema, 3/3 very slight edema, & 

### 3/3 desquamation. On day 10,3/3 velY slight erythema, 

### 2/3
very slight edema, & 

### 3/3 desquamation. By day 14, 

### 3/3 very slight erythema & 

### desquamation.

### DAT:" REVIEW FOR DERMAL SENSiTiZATiON TESTING (§81-6, 870.2600)

Product Manager: Jim Tompkins, 25 MRlD No.: 468773-08

Testing Facility: Product Safety Labs Author: G. Moore

Quality 

### Assurance (40 eFR §160.12): Included Reviewer: Marianne Lewis Study Completion Date: 5/15/06 

### Report No.: 19091



### Test Material: Thidiazuron-Diuron EC, amber liquid

Positive Control Material: HCA historical control (PSL # 

### 18271, 10-14-05)

Spedes: Hartley albino guinea pig vVeight: males"" 297

-- 380 g Age: young adult Source: Elm Hill Breeding Labs

Method: Buchler

Summary:

1. This Product is a non sensitizer

2. Classification: Acceptable

Procedure (Deviation From §81-6): none

Procedu.rc:



### A group of animals were used to detennine the highest non-irritating concentration (HNIC) of the

test subr,<,.ance prior to the challenge dose. The HNlC for the test substance was detennined to be 6% w/w mixture in mineral oil.

The test animals were induced with 0.4 !TIl of 75% test material in mineral oil once a week for three weeks using a Hill Top Chamber. Twenty four hours after each induction dose the animals

were scored for irritation. Two weeks after the last iIlduction dose, 0.4 ml of6% w/w of test material in mineral oil was used to challcnge the test animals. Twenty four and 48 hours after the challenge the animals were evaluated for sensitization.

A group often animals were used as naive controls. These animals received only the challenge doses of the tcst material.

### Results: Due to initation and residue adhesi\'e from the tape the test sites were moved for the second and third induction doses.

Twenty four hours after the first induction dose for the test material-induced animals, 5/20 

### exhibited very faint erythema and 12/20 

### faint erythema. After the second induction dose, 10/20 exhibited very faint erythema and 6/20 

### faint el)1:hema. After the third induction dose, 8/20 

### exhibited very faint erythema, 9/20 

### faint erythema, and 1120 

### well defined erythema at the test site.

Twenty four hours after challenge, 8/20 

### test material-induced animals exhibited very faint erythema.

At 24 hours, in the naive control group of animals challenged with the test material, 4/10 

### exhibited very faint erythema.

### ACUTE TaX ONE-LINER



### I. PC CODE: 035505 2. CURRENT DATE: 

### February 21, 2007 3. TEST MATERIAL Thidiazuron-Diuron EC, amber liquid Diuron: 6.0%, Thidiazuron: 12.0%



# Ii S 1 - . / 

## I tliC y/Speclcs 

### MRllJ # 

# I Lab/Study#!Date 

# ! acu,te oral 

## toxicity/rau,product 46877303 

# I Salety Labsll 9086/5-15-06 

# ! acute deonal

# t~xicitY/rat! 46877304

Product Safety Labs1l9087! 5-15-06 

# II--

1 

### acute inhalation ioxicitylfatl 46877305 

# I Product Safety LabslI 90881



### , 5-15-06

# I~~ry**eY~-iITitation/rabbit!** 46877306**~(()duct** 

### Satety Labs!! 9089!

5

.. )5-06 

# I primary dermal irritation/rabbit! 46877307

Product Safety Labs/190901 

### 1**~** 

### 5··15-06 

# II

I 

# I

, 

# I skin sensitization/h'liinea pig! 46877308

Product Safety Labs! 19091 

### i I, 

### 5-15-06

.. 

## -I'

# ;;x~1 Core 

# 1**~attGrade ~I**  Results 

# I

LD" 

### > 5000 mg/kg 

# I ! 

## V A 

## l! 

# ---1-

# ~-"1-t--11 LD," > 

### 5000 mg/kg I 

# I'

- LD;u> 2.01 

## mgiL I

MMAD**~** 

### 3.0**~m:** 

### GSD**~** 

### U5 

# ---

# ---~ V 

# I A

# ~ 

# I
:1



## -. 

# _ ...... 

# -- t- 

# -l------ll

--

.. 

# - At 1 hr., 113 very 

### slight erythema, 2/3 

# '

, 

## V 

# I t 1 

# I 

# +--t--"--II

I

I 

# r well defined erythema, & 

### 3/3 very slight 

# ! 1 I Ai 

## I I 

### edema. From 24 to 48 hrs., 2/3 

### well defined erythema, 

### 113 moderate to

severe erythema, & 

### 3/3 slight edema. At 72 hrs., 

### 3/3 well defined erythema, 

### 3/3 slight edema, & 

### 2/3 hyperkeratosis. On day 7, 3/3 very slight erythema, 

### 3/3

very slight edema. 3/3 desquamation. On day 10, 3!3 very slight erythema, 2/3

very slight edema, 3/3 desquamation. By day 14, 

### 3/3 very slight erythema & 

### desquamation.

Non sensitizer

.. 

## - 

# I I



# - 

# i
I'


# I

I 

# 'I

II 

# I

# ~-1 I

.II**~** 

### .. 

### Core (rrade l

.... ey:A "" Acceptable, S = 

### Supplementary,U = 

### Unacceptable,V 0= 

### self-Validated

### lABELING:



### !D #: 

### 066330-00033 

### THIDIAZURON-DIURON EC

RESTRICTED USE CLASSIFICA nON RECOMMENDED:

Due to primary eye irritation toxicity category.

SIGNAL WORD: DANGER PELIGRO

HAZARDS TO HUMANS AND DOMESTIC ANIMALS:

COITosive. Causes ilTcversible eye damage. Causc3 skin in'itation. Do nol get ill eyes, on skin, or on clothing. Wear protective eyewcar (goggles, face shield, or safety glasses), 

### coveralls over Sh011 sleeved shirt a!\d short pants, chemical resistant shoes, socks, and chemical resistant gloves (barrier iamillate 

### or butyl rubber, selection category B).



### FIRST AID:

IF IN EYES: Hold eye open and rinse slowly and gentiy with water fOr J**S~20** 

### minutes. 

### Remove contact lenses, ifprest:lIt, after the first 

### 5 mirmtts, then continue rinsir;f eye. Call



### a poison control center or doctor fi:H 

### treatment advicc.

IF ON SKIN OR CLOTHING: 

### Take off 

### contmnirlated clolhing. 

### Rillse skin irruTI.ediately with plenty of water for) 5-20**minut~s.** 

### Call a poison control cenier or 

### doctor for

treatment advice.

Have the product colltaine( or label with you when calli!lg a poison control center or doctor 

## or going for treatment. You may also contact 

## 1-800-xxx-xxxx for emergency medical treatment inlormation.

lISERSAFETY RECOMMENDATIONS:

User should wash hands before eating, drinking, chewing gUlli, using tobacco. or**u~ing** 

### the toi 

### I et.

User shollld remove clothing/PPE immediately tfpesticide gets inside. Then lVash thoroughly and put on dean dothing

.

. Users should remove 

## prE immediately Hfter handling this product. Wash thc**outsid~** 

### of

gloves before removing. As soon as possible, '

.. vash thoroughly and change**~nto** 

### clear, clothing.

The proposed label must contain the following guidance:

### NOTE TO PHYSICIAN:

Probable mucosal damage may contraindicate the use of gastric lavage.



## ----------------------

Notc to CRM/PJVflRegistrant:

The proposed label should contain a Note to Physician which addresses the primary**~ye** 

### irritation Toxicity Category \. The following statements are some suggested types of illfonnation that could be included, if applicable, in the Note to Physicians;

- technical in(ormmion on symptomatology;

.. use of supportive treatments to maintain life**functions~**



### - medicine that will counteract the specific physiological effects of the pesticide;

- company telephone 

### ilumber to specific medica! personnel who can provide

speciaiized medical advice.

### DATE OUT: 

### 17/MAY/07

SUBJECT: PRODUCT CHEMISTRY REVIEW OF: TGAI 

## II: MUP 

## II: EUP 

## Ixl
BARCODE NO.: 339926 REG.IFILE SYMBOL NO.: 66330-333 PRODUCT NAME: Thidiazuron-Diuron EC COMPANY NAME: Arysta LifeScience North America Com. 

# h.l'

# ~C~~1 FROM: Maria Rivera Piansay, Chemist**t\4..l~\,** 

## . Product Chemistry Team 

# 1: \

PRBISRRD 

### (7508C)

TO: Barbara Briscoe, CRM Product Reregistration Branch Special Review and Reregistration Division (7508C)



### INTRODUCTION: ACTION CODE: 675

In 

### response to our review of 5/1/07, 

### Arysta LifeScience North America Corporation submitted revised basic and alternate formulation Confidential Statements ofFonnula (CSFs), both dated 5/8/07, 

### in support of the reregistration of 

### Thidiazuron-Diuron 

### Ee, EPA Reg. No. 66330-333.

FINDINGS:

1. Previously, the registrant was requested to clarifY the inconsistency between the basic and the alternate CSF in 

### declaring the purity of the The basic CSF declared while the alternate claimed The registrant responded 

### by submitting revised CSFs showing

a different Diuron source. According to the current CSFs, the technical Diuron currently used in fonnulating this product is now , with a purity of With this revision, the CSFs are now found acceptable to support this product. The nominal concentrations of the active ingredients agree with that on the label, meeting PR Notice 91-2. The certified limits on the active and inert ingredients are acceptable as per 40 CFR 158.175(b)(2). All ingredients listed on the CSFs are cleared for use in pesticide fonnulations.

2. The Ingredients statements are 

### in compliance with the requirements of 40 CFR 156.1 O(g). The Physical or Chemical Hazards subheading is not triggered based on the physical/chemical characteristics of the product. The Storage and Disposal section of the label is acceptable in 

### accordance with 40 CFR 156.10 (i)(2)(ix).



### CONCLUSIONS:

The registrant has now satisfied product chemistry data requirements for the reregistration of EPA Reg. No. 

### 66330-333,

M.R. pjansay and Cenlfal File (EPA Reg. No. 66330-333) 7508C:SRRD:PRB:CM-2: M.R.P.: (171MA YI07):703-308-8063:<66330-333>

### DATE OUT: OI/MAY/07

SUBJECT: PRODUCT CHEMISTRY REVIEW OF: TGAI [I; 

### MUP [I; 

### EUP [xl 

### BARCODE NO.: 336741 REGJFILE SYMBOL NO.: 66330-333 PRODUCT NAME: Thidiazuron-Diuron EC MRID NOS.: 46?364-01, 462364-03, 462364-04 COMPANY NAME: Arysta LifeScience North America Corp. ACTION CODE: 674 

# r

FROM: Maria Rivera Piansay, Chemist

# f.~~ 

# J**,,--,,!~** Product Chemistry Team 

# l U PRB/SRRD 

### (7508C)

TO: Barbara Briscoe, CRM Product Reregistration Branch Special Review and Reregistration Division (7508C)



### INTRODUCTION:

A Reregistration 

### Eligibility Decision (RED), Case number 0046, was issued in September, 2003 for the Technical Grade Active Ingredient (TGAI) Diuron. According to the RED, the generic data base supporting the reregistration of Diuron have been reviewed and found to be substantially complete.

In the 8-month response to the Diuron RED, Arysta LifeScience North America Corporation submitted a basic and an alternate formulation Confidential Statement of Formula (CSF), dated 2/5/07; 

### a draft label, EPA received 2/S/07; 

### and product chemistry data in MRJD numbers462364-0 1,462364-03 and 462364-04. The registrant is requesting FIFRA Section 4 reregistration ofThidiazuron-Diuron EC, EPA Reg. No. 66330-333.



### FINDINGS:

1. EPA Reg. No. 66330-333 is an end-use product that contains Diuron and Thidiazuron froln registered

sources (EPA Reg. No. 66330-324 and respectively) at label claim nominal concentrations of 6.0% and 12.0%, respectively.

2. The CSFs for the basic and the alternate formulations are not acceptable at this time because of an inconsistency in the purity of the The basic CSF declares while the alternate claims The registrant must clarify this discrepancy.

3. The product chemistry data presented in MRID numbers 462364-0 1,462364-03, and 462364-04

are adequate and satisfy the product chemistry data requirements under Subgroups A and B which pertain to Product Identity, Composition and Analysis, and Physical and Chemical Properties, respectively.

4. The Ingredients statements are in compliance with the requirelnents of 40 CFR I56.10(g). The Physical or Chemical Hazards subheading is not triggered based on the physical/chemical characteristics of the product. The Storage and Disposal section of the label is acceptable in accordance with 40 CFR 156.10 (i)(2)(ix).

CONCLUSIONS: Except for Finding 2, the registrant has satisfied product chemistry data requirements for the reregistration of EPA Reg. No. 66330-333.



### THIS REVIEW CONTAINS FIFRA CBl

## 2

REVIEW OF PRODUCT CHEMISTRY DATA: PRODUCT NAME: Thidiazuron-Diuron EC EPA Reg. No: 66330-333 Group A: Series 830-Product Identity, Composition, and Analysis (40 CFR158.I55, .160, .165, .167, .170, .175 & 

### .180).

830-1550 Product Identitv and Composition

EPA Reg. No. 66330-333 is an end-use product produced through a non-integrated formulation system. The active ingredients Diuron and Thidiazuron are claimed in the label at 6.0% and 12.0%, respectively. Description of materials used in the formulation of this product is found in MRID 

### number 459373-01 and on the eSF.



### 830-1600 Description of Materials Used to Produce the Product

Refer to Confidential Appendix A.



### 830-1620 Discussion of Formulation Process

Refer to Confidential Appendix A.



### 830-1670 Discussion of Formation of Impurities

Refer to Confidential Appendix A.



### 830-1700 Preliminary Analysis

Refer to Confidential**App~ndix** 

### A

830-1750 Certified Limits

Refer to Confidential Appendix A.

830-1800 Enforcement of Analytical Method

The registrant cited a validated analytical method for the analyis of Diuron and Thidiazuron (MRID number 468773-02). The active ingredients are extracted from the fonnulated product using methanol, and analyzed by HPLC with detection by UVNis absorption. This analytical method had been previously reviewed and accepted and determined to satisfy GRN 830.1800.



### THIS REVIEW CONTAINS FIFRA CBl

## 3

Product Chemistry Data Subgroup A: Series 830.1550

- 830.1800 (40 CFR IS8.1S5

- 158.180)

GUIDELiNE REFERENCE NO. 

### MRIDNumber Data (GRN)/ TITLE 830 

### Fulfilled

. 1550 Product Identity and 

### COI!1position 462364-04

. 

### Y



### .1600 Description of Materials Used to 462364-04 Y 

### Produce the Product

.1620 Description of Formulation Process 462364-04 Y



### .1650 Discussion of Formation of 462364-04 Y 

### Impurities



### .1700 Preliminary Analysis N/A N/A

.1750 Certified Limits 462364-04 and CSF Y



### .1800 Enforcement Analytical Method 462364-04 

### y

Subgroup B: Series 830.6302 -7950 (40 CFR 158.190)

GUIDELINE REFERENCE VALUE OR NO. QUALITATIVE MRID 

### Data Fulfilled (GRN)/ TITLE 830 DESCRIPTION Number

.6302 

### Color Amber 468773-01 Y



### .6303 Physical State Liquid at 25°C 

### 462364-01, -03 Y



### .6304 Odor 

### Amine 

### 468773-01 

### y

.6314 Oxidation/Reduction: Chemically stable to the action 462364-01, -03 Y 

### Chemical Incompatibility of water, Iron powder, and Monoammonium phosphate The test material underwent a mild oxidation reaction in the
presence of a potassium pennanganate solution.



### .6315 Flammability/Flame Y 

### Extension 

### >93°C 462364-0 I, -03

.6316 Explodability 

### N/A N/A 462364-01, -03

## 4

.6317 Storage Stability Post-storage (duplicate) analyses of the product (one- 468773-02 

### y

year, room-temperature storage) yielded Diuron results 

### ranging from 5.92 

### to 6.18%
with an average of 6.02%. Thidiazuron results ranged 

### from 11.83 

### to 12.12% with 

### an average of 11.96%.

.6318 Viscosity 70 

### mpas@ 25°C 462364-01 

### Y

64 mpas 

### @ 25°C 462364-03

.6320 Corrosion Corrosion testing was 468773-02 

### Y
Characteristics conducted in combination with the Storage Stability testing. Product container (HDPE) retained its original condition after one year of storage at

room temperature.

.6321 Dielectric Breakdown N/A



## --- N/A Voltage

.7000 

### pH 5.60 @ 25"C 462364-01 

### Y

5.46 @25"C 462364-03 

### .7300 Density/Relative Density/Bulk Density 0.9935 g/mL @ 25"C 462364-01 

### Y

0.9938 g/mL (aJ 

### 25"C 462364-03

Explanations; Y = 

### Requirement fulfilled; N = 

### Requirement not fulfilled; 

### N/A = 

### Not applicable; G = 

### Data gap



### THIS REVIEW CONTAINS FIFRA CBl

### Confidential Appendix A



### 830-1750 Certified Limits

Diuron: Lower Limit: 5.7%; Nomina! Conc.: 6.0%; Upper Limit: 6.3% Thidiazuron: Lower Limit: 11.4%; Nominal Conc.: 12.0%; Upper Limit: 12.6%

M.R. J'iansay ilnd Central File (EPA Reg. No. 66330-333) 7508C:SRRJ):I'RB:CM·2: M.R.P.: (0 liMA YI07}:703-308-8063:<66330-333>



## THIS REVIEW CONTAINS FIFRA CBI