EX-4.2



 Exhibit 4.2 
 EXECUTION VERSION 
 EPIZYME, INC. 

AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 
 April 2, 2012 







 TABLE OF CONTENTS 

 

							
	 	 	 	  	Page	 
	 1. Certain Definitions
	  	 	1	  
		
	 2. Registration Rights
	  	 	5	  
	 2.1
	 	Required Registrations	  	 	5	  
	 2.2
	 	Incidental Registration	  	 	7	  
	 2.3
	 	Registration Procedures	  	 	8	  
	 2.4
	 	Allocation of Expenses	  	 	11	  
	 2.5
	 	Indemnification and Contribution	  	 	11	  
	 2.6
	 	Other Matters with Respect to Underwritten Offerings	  	 	14	  
	 2.7
	 	Information by Holder	  	 	14	  
	 2.8
	 	“Lock-Up” Agreement; Confidentiality of Notices	  	 	14	  
	 2.9
	 	Limitations on Subsequent Registration Rights	  	 	15	  
	 2.10
	 	Rule 144 Requirements	  	 	15	  
	 2.11
	 	Termination	  	 	16	  
		
	 3. Right of First Refusal
	  	 	16	  
	 3.1
	 	Rights of Purchasers to Acquire Offered Securities	  	 	16	  
	 3.2
	 	Termination	  	 	19	  
		
	 4. Covenants
	  	 	19	  
	 4.1
	 	Negative Covenants	  	 	19	  
	 4.2
	 	Affirmative Covenants	  	 	20	  
	 4.3
	 	Inspection and Observation	  	 	21	  
	 4.4
	 	Financial Statements and Other Information	  	 	21	  
	 4.5
	 	Material Changes and Litigation	  	 	23	  
	 4.6
	 	D&O Insurance	  	 	23	  
	 4.7
	 	Agreements with Employees; Options	  	 	23	  
	 4.8
	 	Board of Directors	  	 	24	  
	 4.9
	 	Related Party Transactions	  	 	24	  
	 4.10
	 	Reservation of Common Stock	  	 	24	  
	 4.11
	 	International Investment and Trade in Services Survey Act	  	 	25	  
	 4.12
	 	Market Stand-Off Agreement with Future Security Holders; Right of First Refusal	  	 	25	  
	 4.13
	 	Termination of Covenants	  	 	25	  
		
	 5. Confidentiality
	  	 	25	  
		
	 6. Transfers of Rights; Calculation of Share Numbers
	  	 	26	  
	 6.1
	 	Transfer of Rights	  	 	26	  
	 6.2
	 	Calculation of Share Numbers	  	 	26	  
		
	 7. General
	  	 	26	  
	 7.1
	 	Severability	  	 	26	  


  
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	 	 	 	  	Page	 
	 7.2
	 	Specific Performance	  	 	26	  
	 7.3
	 	Governing Law	  	 	26	  
	 7.4
	 	Notices	  	 	26	  
	 7.5
	 	Complete Agreement	  	 	27	  
	 7.6
	 	Amendments and Waivers	  	 	27	  
	 7.7
	 	Amendment and Restatement of Prior Agreement	  	 	28	  
	 7.8
	 	Pronouns	  	 	28	  
	 7.9
	 	Counterparts; Facsimile Signatures	  	 	28	  
	 7.10
	 	Section Headings and References	  	 	28	  


  
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 EPIZYME, INC. 
 AMENDED AND RESTATED INVESTOR RIGHTS AGREEMENT 
 This Agreement dated as of
April 2, 2012 is entered into by and among Epizyme, Inc., a Delaware corporation (the “Company”) and the individuals and entities listed on Exhibit A attached hereto (individually, a “Purchaser” and,
collectively, the “Purchasers”). 
 Recitals 

WHEREAS, the Company and one of the Purchasers have entered into a Series C Convertible Preferred Stock Purchase Agreement of even date
herewith (the “Series C Purchase Agreement”), pursuant to which such Purchaser is purchasing shares of Series C Convertible Preferred Stock, par value $0.0001 per share (the “Series C Preferred Stock”), of the Company;

 WHEREAS, the Company and certain of the Purchasers previously entered into a Series B Convertible Preferred Stock Purchase
Agreement, dated as of September 18, 2009, as amended (the “Series B Purchase Agreement”), pursuant to which certain of the Purchasers purchased shares of Series B Convertible Preferred Stock, par value $0.0001 per share (the
“Series B Preferred Stock”), of the Company; 
 WHEREAS, the Company and certain of the Purchasers previously entered
into a Series A Convertible Preferred Stock Purchase Agreement, dated as of February 28, 2008 (the “Series A Purchase Agreement”), pursuant to which certain of the Purchasers purchased shares of Series A Convertible Preferred Stock,
par value $0.0001 per share (the “Series A Preferred Stock”), of the Company; 
 WHEREAS, the Company and the
Purchasers desire to provide for certain arrangements with respect to (i) the registration of shares of capital stock of the Company under the Securities Act (as defined below), (ii) certain Purchasers’ right of first refusal with
respect to certain issuances of securities of the Company, and (iii) certain covenants of the Company; 
 WHEREAS, the
Company and the Purchasers holding Series A Preferred Stock and Series B Preferred Stock are parties to an Amended and Restated Investor Rights Agreement, dated as of September 18, 2009, as amended (the “Prior Investor Rights
Agreement”), and the Company and the such Purchasers desire to amend and restate the Prior Investor Rights Agreement in its entirety pursuant to the terms hereof; 
 NOW, THEREFORE, in consideration of the mutual promises and covenants contained in this Agreement, the parties hereto agree as follows: 

1. Certain Definitions. 
 As used in this Agreement, the following terms shall have the following respective meanings: 







 “Affiliated Party” means, with respect to any Purchaser, any person or
entity which, directly or indirectly, controls, is controlled by or is under common control with such Purchaser, including, without limitation, any general partner, officer or director of such Purchaser and any venture capital fund now or hereafter
existing which is controlled by one or more general partners of, or shares the same management company as, such Purchaser. 

“Available Undersubscription Amount” means the difference between the total of all of the Basic Amounts available for
purchase by Qualified Purchasers pursuant to Section 3.1 and the Basic Amounts subscribed for pursuant to Section 3.1. 
 “Basic Amount” means, with respect to a Qualified Purchaser, its pro rata portion of the Offered Securities determined by multiplying the number of Offered Securities by a fraction, the
numerator of which is the aggregate number of shares of (x) Common Stock issuable upon conversion of all Shares then held by such Qualified Purchaser plus (y) Common Stock purchased by such Qualified Purchaser pursuant to the exercise of
its rights under the Amended and Restated Right of First Refusal and Co-Sale Agreement dated of even date herewith or such other contractual right of first refusal agreement to purchase shares of Common Stock from holders of the Company’s
Common Stock plus (z) in the case of Affiliated Parties of MPM BioVentures IV-QP, LP an aggregate of 535,000 shares of Common Stock (subject to appropriate adjustment for stock splits, stock dividends, recapitalizations and similar events
occurring after the date of this Agreement) held as of the date of this Agreement and the denominator of which is the total number of shares of Common Stock then outstanding (giving effect to the conversion into Common Stock of all outstanding
shares of convertible preferred stock and to the issuance of all shares of Common Stock reserved for issuance upon exercise of outstanding options to purchase shares of Common Stock. 

“Code” means the Internal Revenue Code of 1986, as amended. 

“Commission” means the Securities and Exchange Commission, or any other federal agency at the time administering the
Securities Act. 
 “Common Stock” means the common stock, $0.0001 par value per share, of the Company.

 “Company” has the meaning ascribed to it in the introductory paragraph hereto. 

“Company Sale” means a Deemed Liquidation Event as such term is defined in the Amended and Restated Certificate of
Incorporation, as amended from time to time. 
 “Company Subsidiary” means any corporation, partnership, trust,
limited liability company or other non-corporate business enterprise in which the Company (or another Company Subsidiary) holds stock or other ownership interests representing (a) more than 50% of the voting power of all outstanding stock or
ownership interests of such entity or (b) the right to receive more than 50% of the net assets of such entity available for distribution to the holders of outstanding stock or ownership interests upon a liquidation or dissolution of such
entity. 

  
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 “Confidential Information” means any information that is labeled as
confidential, proprietary or secret which a Purchaser obtains from the Company pursuant to financial statements, reports and other materials provided by the Company to such Purchaser pursuant to this Agreement or pursuant to visitation or inspection
rights granted hereunder. 
 “Exchange Act” means the Securities Exchange Act of 1934, as amended, or any
successor federal statute, and the rules and regulations of the Commission issued under such Act, as they each may, from time to time, be in effect. 
 “Indemnified Party” means a party entitled to indemnification pursuant to Section 2.5. 
 “Indemnifying Party” means a party obligated to provide indemnification pursuant to Section 2.5. 
 “Initial Public Offering” means the initial underwritten public offering of shares of Common Stock pursuant to an effective Registration Statement. 

“Initiating Holders” means the Purchasers initiating a request for registration pursuant to Section 2.1(a) or
2.1(b), as the case may be. 
 “Major Purchaser” means each Purchaser owning not less than 900,000 Shares
(subject to appropriate adjustment for stock splits, stock dividends, recapitalizations and similar events occurring after the date of this Agreement). 
 “Notice of Acceptance” means a written notice from a Purchaser to the Company containing the information specified in Section 3.1(b). 

“Offer” means a written notice of any proposed or intended issuance, sale or exchange of Offered Securities containing
the information specified in Section 3.1(a). 
 “Offered Securities” means (a) any shares of Common
Stock, (b) any other equity securities of the Company, including, without limitation, shares of preferred stock, (c) any option, warrant or other right to subscribe for, purchase or otherwise acquire any equity securities of the Company,
or (d) any debt securities convertible into capital stock of the Company. 
 “Other Holders” means holders
of securities of the Company (other than Purchasers) who are entitled, by contract with the Company, to have securities included in a Registration Statement. 
 “Preferred Stock” means the Series A Preferred Stock, the Series B Preferred Stock and the Series C Preferred Stock. 

“Preferred Directors” shall mean the Preferred Directors as such term is defined in the Amended and Restated Certificate
of Incorporation of the Company. 
 “Prior Investor Rights Agreement” shall have the meaning ascribed to it in
the recitals hereto. 

  
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 “Prospectus” means the prospectus included in any Registration Statement,
as amended or supplemented by an amendment or prospectus supplement, including post-effective amendments, and all material incorporated by reference or deemed to be incorporated by reference in such Prospectus. 

“Public Company Sale” means a Company Sale that involves another party that is subject to and substantially in
compliance with the reporting requirements of the Exchange Act. 
 “Purchaser” has the meaning ascribed to it
in the introductory paragraph hereto. 
 “Qualified Purchaser” means a Major Purchaser that is an
“accredited investor” within the meaning of Rule 501(a) under the Securities Act. 
 “Refused
Securities” means those Offered Securities as to which a Notice of Acceptance has not been given by the Qualified Purchasers pursuant to Section 3.1. 
 “Registrable Shares” means (a) the shares of Common Stock issued or issuable upon conversion of the Shares, (b) any other shares of Common Stock, and any shares of Common Stock
issued or issuable upon the conversion or exercise of any other securities, acquired by the Purchasers pursuant to Section 3 of this Agreement or pursuant to the Amended and Restated Right of First Refusal and Co-Sale Agreement among the
Company, the Purchasers and certain other parties thereto dated the date hereof, (c) in the case of Affiliated Parties of MPM BioVentures IV-QP, LP, an aggregate of 535,000 Shares of Common Stock (subject to appropriate adjustment for
stock splits, stock dividends, recapitalizations and similar events occurring after the date of this Agreement) held as of the date of this Agreement and (d) any other shares of Common Stock issued in respect, replacement, or exchange of such
shares (because of stock splits, stock dividends, reclassifications, recapitalizations or similar events); provided, however, that shares of Common Stock which are Registrable Shares shall cease to be Registrable Shares (i) upon
any sale pursuant to a Registration Statement or Rule 144 under the Securities Act, (ii) upon any sale in any manner to a person or entity which is not entitled, pursuant to Section 6, to the rights under this Agreement, or
(iii) at such time, following an Initial Public Offering, as they become eligible for sale pursuant to Rule 144(b)(1) under the Securities Act. Wherever reference is made in this Agreement to a request or consent of holders of a certain
percentage of Registrable Shares, the determination of such percentage shall include shares of Common Stock issuable upon conversion of the Shares even if such conversion has not been effected. 

“Registration Expenses” means all expenses incurred by the Company in complying with the provisions of Section 2,
including, without limitation, all registration and filing fees, exchange listing fees, printing expenses, fees and expenses of counsel for the Company and the fees and expenses of one counsel selected by the Selling Stockholders to represent the
Selling Stockholders, state Blue Sky fees and expenses, and the expense of any special audits incident to or required by any such registration, but excluding underwriting discounts, selling commissions and the fees and expenses of Selling
Stockholders’ own counsel (other than the counsel selected to represent all Selling Stockholders). 

  
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 “Registration Statement” means a registration statement filed by the
Company with the Commission for a public offering and sale of securities of the Company (other than a registration statement on Form S-8 or Form S-4, or their successors, or any other form for a similar limited purpose, or any registration statement
covering only securities proposed to be issued in exchange for securities or assets of another corporation). 

“Securities Act” means the Securities Act of 1933, as amended, or any successor federal statute, and the rules and
regulations of the Commission issued under such Act, as they each may, from time to time, be in effect. 
 “Selling
Stockholder” means any Purchaser owning Registrable Shares included in a Registration Statement. 
 “Series A
Preferred Stock” has the meaning ascribed to it in the recitals hereto. 
 “Series A Purchase
Agreement” has the meaning ascribed to it in the recitals hereto. 
 “Series B Preferred Stock” has
the meaning ascribed to it in the recitals hereto. 
 “Series B Purchase Agreement” has the meaning ascribed to
it in the recitals hereto. 
 “Series C Preferred Stock” has the meaning ascribed to it in the recitals hereto.

 “Series C Purchase Agreement” has the meaning ascribed to it in the recitals hereto. 

“Shares” means (i) shares of Series A Preferred Stock issued pursuant to the terms of the Series A Purchase
Agreement, (ii) shares of Series B Preferred Stock issued pursuant to the terms of the Series B Purchase Agreement and (iii) shares of Series C Preferred Stock issued pursuant to the terms of the Series C Purchase Agreement. 

“Undersubscription Amount” means, with respect to a Qualified Purchaser, any additional portion of the Offered
Securities attributable to the Basic Amounts of other Qualified Purchasers as such Qualified Purchaser indicates it will purchase or acquire should the other Qualified Purchasers subscribe for less than their Basic Amounts. 

2. Registration Rights. 
 2.1 Required Registrations. 
 (a) At any time after the earlier of
(i) three years after the date of this Agreement or (ii) six months after the closing of the Initial Public Offering, a Purchaser or Purchasers holding in the aggregate at least 50.1% of the Registrable Shares then outstanding may request,
in writing, that the Company effect the registration on Form S-1 (or any successor form) of Registrable Shares owned by such Purchaser or Purchasers having an aggregate value of at least $5,000,000 (based on the market price or fair value on
the date of such request). 

  
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 (b) At any time after the Company becomes eligible to file a Registration Statement on
Form S-3 (or any successor form relating to secondary offerings), a Purchaser or Purchasers holding in the aggregate at least 50.1% of the Registrable Shares may request, in writing, that the Company effect the registration on Form S-3 (or
such successor form), of Registrable Shares having an aggregate value of at least $3,000,000 (based on the public market price on the date of such request). 
 (c) Upon receipt of any request for registration pursuant to this Section 2, the Company shall promptly give written notice of such proposed registration to all other Purchasers. Such Purchasers
shall have the right, by giving written notice to the Company within 30 days after the Company provides its notice, to elect to have included in such registration such of their Registrable Shares as such Purchasers may request in such notice of
election, subject in the case of an underwritten offering to the terms of Section 2.1(d). Thereupon, the Company shall, as expeditiously as possible, use its best efforts to effect the registration on an appropriate registration form of all
Registrable Shares which the Company has been requested to so register; provided, however, that in the case of a registration requested under Section 2.1(b), the Company will only be obligated to effect such registration on Form S-3 (or any
successor form). 
 (d) If the Initiating Holders intend to distribute the Registrable Shares covered by their request by means
of an underwriting, they shall so advise the Company as a part of their request made pursuant to Section 2.1(a) or (b), as the case may be, and the Company shall include such information in its written notice referred to in Section 2.1(c).
In such event, (i) the right of any other Purchaser to include its Registrable Shares in such registration pursuant to Section 2.1(a) or (b), as the case may be, shall be conditioned upon such other Purchaser’s participation in such
underwriting on the terms set forth herein, and (ii) all Purchasers including Registrable Shares in such registration shall enter into an underwriting agreement upon customary terms with the underwriter or underwriters managing the offering;
provided that such underwriting agreement shall not provide for indemnification or contribution obligations on the part of the Purchasers materially greater than the obligations of the Purchasers pursuant to Section 2.5 as with respect to the
persons indemnified pursuant to Section 2.5. The Initiating Holders shall have the right to select the managing underwriter(s) for any underwritten offering requested pursuant to Section 2.1(a) or (b), subject to the approval of the
Company, which approval will not be unreasonably withheld, conditioned or delayed. If any Purchaser who has requested inclusion of its Registrable Shares in such registration as provided above disapproves of the terms of the underwriting, such
Purchaser may elect, by written notice to the Company, to withdraw its Registrable Shares from such Registration Statement and underwriting. If the managing underwriter advises the Company in writing that marketing factors require a limitation on
the number of shares to be underwritten and after reducing any other shares included in such registration to zero, including any Company shares, the number of Purchaser Registrable Shares to be included in the Registration Statement and underwriting
shall be allocated among all Purchasers requesting registration in proportion, as nearly as practicable, to the respective number of Registrable Shares held by them on the date of the request for registration made by


  
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the Initiating Holders pursuant to Section 2.1(a) or (b), as the case may be. If any Purchaser would thus be entitled to include more Registrable Shares than such Purchaser requested to be
registered, the excess shall be allocated among other requesting Purchasers pro rata in the manner described in the preceding sentence. 
 (e) The Company shall not be required to effect (nor pay for) more than two registrations pursuant to Section 2.1(a) or more than two registrations within any 12-month period pursuant to
Section 2.1(b) (in each case, counting for these purposes only registrations which have been declared or ordered effective, remain in effect and no stop order is then in effect or pursuant to which the distribution described therein has been
completed). In addition, the Company shall not be required to effect any registration within six months after the effective date of the Registration Statement relating to the Initial Public Offering. For purposes of this Section 2.1(e), a
Registration Statement shall not be counted until such time as such Registration Statement has been declared effective by the Commission (unless the Initiating Holders withdraw their request for such registration and elect not to pay the
Registration Expenses therefor pursuant to Section 2.4 (other than as a result of information concerning the business or financial condition of the Company which is made known to the Purchasers after the date on which such registration was
requested)). For purposes of this Section 2.1(e), a Registration Statement shall not be counted if, as a result of an exercise of the underwriter’s cut-back provisions, less than 50% of the total number of Registrable Shares that
Purchasers have requested to be included in such Registration Statement are so included. 
 (f) If at the time of any request
to register Registrable Shares by Initiating Holders pursuant to this Section 2.1, the Company is engaged or has plans to engage in a registered public offering or is engaged in any other activity which, in the good faith determination of the
Company’s Board of Directors, would be adversely affected by the requested registration, then the Company may at its option direct that such request be delayed for a period not in excess of 30 days from the date of such request, such right to
delay a request to be exercised by the Company not more than once in any 12-month period. 
 2.2 Incidental Registration.

 (a) Whenever the Company proposes to file a Registration Statement (other than a Registration Statement filed pursuant to
Section 2.1) at any time and from time to time, it will, prior to such filing, give written notice to all Purchasers of its intention to do so; provided, that no such notice need be given if no Registrable Shares are to be included therein as a
result of a written notice from the managing underwriter pursuant to Section 2.2(b). Upon the written request of a Purchaser or Purchasers given within 20 days after the Company provides such notice (which request shall state the intended
method of disposition of such Registrable Shares), the Company shall use its best efforts to cause all Registrable Shares which the Company has been requested by such Purchaser or Purchasers to register to be registered under the Securities Act to
the extent necessary to permit their sale or other disposition in accordance with the intended methods of distribution specified in the request of such Purchaser or Purchasers; provided that the Company shall have the right to postpone or withdraw
any registration effected pursuant to this Section 2.2 without obligation to any Purchaser. 

  
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 (b) If the registration for which the Company gives notice pursuant to Section 2.2(a)
is a registered public offering involving an underwriting, the Company shall so advise the Purchasers as a part of the written notice given pursuant to Section 2.2(a). In such event, (i) the right of any Purchaser to include its
Registrable Shares in such registration pursuant to this Section 2.2 shall be conditioned upon such Purchaser’s participation in such underwriting on the terms set forth herein and (ii) all Purchasers including Registrable Shares in
such registration shall enter into an underwriting agreement upon customary terms with the underwriter or underwriters selected for the underwriting by the Company; provided that such underwriting agreement shall not provide for
indemnification or contribution obligations on the part of Purchasers materially greater or different than the obligations of the Purchasers pursuant to Section 2.5. If any Purchaser who has requested inclusion of its Registrable Shares in such
registration as provided above disapproves of the terms of the underwriting, such person may elect, by written notice to the Company, to withdraw its shares from such Registration Statement and underwriting. If the managing underwriter advises the
Company in writing that marketing factors require a limitation on the number of shares to be underwritten, the shares held by (1) Other Holders and by holders of securities of the Company other than the Purchasers and Other Holders shall be
excluded from such Registration Statement and underwriting to the extent deemed advisable by the managing underwriter, and (2) if a further reduction of the number of shares is required, the number of shares that may be included in such
Registration Statement and underwriting shall be allocated among all Purchasers requesting registration in proportion, as nearly as practicable, to the respective number of shares of Common Stock (on an as-converted basis) held by them on the date
the Company gives the notice specified in Section 2.2(a); provided, that, unless such registration is in connection with the Company’s Initial Public Offering, the number of Registrable Shares permitted to be included therein shall
in any event be at least 30% of the securities included therein. If any Purchaser or Other Holder would thus be entitled to include more shares than such holder requested to be registered, the excess shall be allocated among other requesting
Purchasers and Other Holders pro rata in the manner described in the preceding sentence. 
 2.3 Registration Procedures.

 (a) If and whenever the Company is required by the provisions of this Agreement to use its best efforts to effect the
registration of any Registrable Shares under the Securities Act, the Company shall: 
 (i) prepare and file with the Commission
a Registration Statement with respect to such Registrable Shares and use its best efforts to cause that Registration Statement to become effective as soon as possible; 
 (ii) to the extent the Company is a well-known seasoned issuer (as defined in Rule 405 under the Securities Act) (a “WKSI”) at the time any request for registration is submitted to the Company
in accordance with Section 2.1, (i) if so requested, file an automatic shelf registration statement (as defined in Rule 405 under the Securities Act) (an “automatic shelf registration statement”) to effect such registration, and
(ii) remain a WKSI (and not become an ineligible issuer (as defined in Rule 405 under the Securities Act)) during the period during which such automatic shelf registration statement is required to remain effective in accordance with this
Agreement; 

  
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 (iii) if at any time when the Company is required to re-evaluate its WKSI status for
purposes of an automatic shelf registration statement used to effect a request for registration in accordance with Section 2.3 (i) the Company determines that it is not a WKSI, (ii) the registration statement is required to be kept
effective in accordance with this Agreement, and (iii) the registration rights of the applicable Holders have not terminated, promptly amend the registration statement onto a form the Company is then eligible to use or file a new registration
statement on such form, and keep such registration statement effective in accordance with the requirements otherwise applicable under this Agreement; 
 (iv) if (i) a registration made pursuant to a shelf registration statement is required to be kept effective in accordance with this Agreement after the third anniversary of the initial effective date
of the shelf registration statement and (ii) the registration rights of the applicable Holders have not terminated, file a new registration statement with respect to any unsold Registrable Securities subject to the original request for
registration prior to the end of the three year period after the initial effective date of the shelf registration statement, and keep such registration statement effective in accordance with the requirements otherwise applicable under this
Agreement; 
 (v) as expeditiously as possible prepare and file with the Commission any amendments and supplements to the
Registration Statement and the prospectus included in the Registration Statement as may be necessary to comply with the provisions of the Securities Act (including the anti-fraud provisions thereof) and to keep the Registration Statement effective
for 12 months from the effective date or such lesser period until all such Registrable Shares are sold; 
 (vi) as
expeditiously as possible furnish to each Selling Stockholder such reasonable numbers of copies of the Prospectus, including any preliminary Prospectus, in conformity with the requirements of the Securities Act, and such other documents as such
Selling Stockholder may reasonably request in order to facilitate the public sale or other disposition of the Registrable Shares owned by such Selling Stockholder; 
 (vii) as expeditiously as possible use its commercially reasonable efforts to register or qualify the Registrable Shares covered by the Registration Statement under the securities or Blue Sky laws of such
states as the Selling Stockholders shall reasonably request, and do any and all other acts and things that may be necessary or desirable to enable the Selling Stockholders to consummate the public sale or other disposition in such states of the
Registrable Shares owned by the Selling Stockholders; provided, however, that the Company shall not be required in connection with this paragraph (iv) to qualify as a foreign corporation or to execute a general consent to service of process in
any jurisdiction or to amend its Certificate of Incorporation or By-laws in a manner that the Board of Directors of the Company determines is inadvisable; 

  
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 (viii) as expeditiously as possible, cause all such Registrable Shares to be listed on each
securities exchange or automated quotation system on which similar securities issued by the Company are then listed; 
 (ix)
promptly provide a transfer agent, registrar and CUSIP number for all such Registrable Shares not later than the effective date of such Registration Statement; 
 (x) promptly make available for inspection by the Selling Stockholders, any managing underwriter participating in any disposition pursuant to such Registration Statement, and any attorney or accountant or
other agent retained by any such underwriter or selected by the Selling Stockholders, all financial and other records, pertinent corporate documents and properties of the Company and cause the Company’s officers, directors, employees and
independent accountants to supply all information reasonably requested by any such seller, underwriter, attorney, accountant or agent in connection with such Registration Statement; 

(xi) notify each Selling Stockholder, promptly after it shall receive notice thereof, of the time when such Registration Statement has
become effective or a supplement to any Prospectus forming a part of such Registration Statement has been filed; 
 (xii) as
expeditiously as possible following the effectiveness of such Registration Statement, notify each seller of such Registrable Shares of any request by the Commission for the amending or supplementing of such Registration Statement or Prospectus;

 (xiii) notify each holder of Registrable Securities covered by such Registration Statement at any time when a Prospectus
relating thereto is required to be delivered under the Securities Act of the happening of any event as a result of which the prospectus included in such Registration Statement, as then in effect, includes an untrue statement of a material fact or
omits to state a material fact required to be stated therein or necessary to make the statements therein not misleading in the light of the circumstances then existing, such obligation to continue for 180 days or until the distribution described in
such Registration Statement is completed, if earlier and following such notification promptly prepare and furnish to such seller a reasonable number of copies of a supplement to or an amendment of such prospectus as may be necessary so that, as
thereafter delivered to the purchasers of such shares, such prospectus shall not include an untrue statement of a material fact or omit to state a material fact required to be stated therein or necessary to make the statements therein not misleading
or incomplete in light of the circumstances then existing; 
 (xiv) advise each Holder promptly after the Company shall receive
notice or obtain knowledge thereof, of the issuance of any stop order by the Commission suspending the effectiveness of such Registration Statement or the threatening of any proceeding for such purpose and promptly use all best efforts to prevent
the issuance of any stop order should such be issued; and 
 (xv) deliver to each Holder of Registrable Securities an earnings
statement of the Company (that will satisfy the provisions of Section 11(a) of the Act) covering a period of 12 months beginning after the effective date of the Registration Statement as soon as is reasonably practicable after the termination
of such 12-month period. 

  
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 (b) If the Company has delivered a Prospectus to the Selling Stockholders and after having
done so the Prospectus is amended to comply with the requirements of the Securities Act, the Company shall promptly notify the Selling Stockholders and, if requested, the Selling Stockholders shall immediately cease making offers of Registrable
Shares and return all Prospectuses to the Company. The Company shall promptly provide the Selling Stockholders with revised Prospectuses and, following receipt of the revised Prospectuses, the Selling Stockholders shall be free to resume making
offers of the Registrable Shares. 
 (c) In the event that, in the judgment of the Company, it is advisable to suspend use of a
Prospectus included in a Registration Statement due to pending material developments or other events that have not yet been publicly disclosed and as to which the Company believes public disclosure would be detrimental to the Company, the Company
shall notify all Selling Stockholders to such effect, and, upon receipt of such notice, each such Selling Stockholder shall immediately discontinue any sales of Registrable Shares pursuant to such Registration Statement until such Selling
Stockholder has received copies of a supplemented or amended Prospectus or until such Selling Stockholder is advised in writing by the Company that the then current Prospectus may be used and has received copies of any additional or supplemental
filings that are incorporated or deemed incorporated by reference in such Prospectus. Notwithstanding anything to the contrary herein, the Company shall not exercise its rights under this Section 2.3(c) to suspend sales of Registrable Shares
for a period in excess of 30 days consecutively or 60 days in any 365-day period. 
 2.4 Allocation of Expenses. The
Company will pay all Registration Expenses for all registrations under this Agreement; provided, however, that if a registration under Section 2.1 is withdrawn at the request of the Initiating Holders (other than as a result of
information concerning the business or financial condition of the Company which is made known to the Selling Stockholders after the date on which such registration was requested) and if the Initiating Holders elect not to have such registration
counted as a registration requested under Section 2.1, the Selling Stockholders shall pay the Registration Expenses of such registration pro rata in accordance with the number of their Registrable Shares included in such registration.

 2.5 Indemnification and Contribution. 
 (a) In the event of any registration of any of the Registrable Shares under the Securities Act pursuant to this Agreement, the Company will indemnify and hold harmless each Selling Stockholder, each
underwriter of such Registrable Shares, and each other person, if any, who controls such Selling Stockholder or underwriter within the meaning of the Securities Act or the Exchange Act against any losses, claims, damages or liabilities, joint or
several, to which such Selling Stockholder, underwriter or controlling person may become subject under the Securities Act, the Exchange Act, state securities or Blue Sky laws or otherwise, insofar as such losses, claims, damages or liabilities (or
actions in respect thereof) arise out of or are based upon (i) any untrue statement or alleged untrue statement of any material fact contained in any Registration Statement under which such Registrable Shares were registered under the
Securities 

  
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Act, any preliminary prospectus or final prospectus contained in the Registration Statement, any free writing prospectus, or any amendment or supplement to such Registration Statement,
(ii) the omission or alleged omission to state a material fact required to be stated therein or necessary to make the statements therein not misleading, or (iii) any violation or alleged violation whether by action or inaction by the
Company of the Securities Act, the Exchange Act, any state securities or Blue Sky law or any rule or regulation promulgated under the Securities Act, the Exchange Act or any state securities or Blue Sky law in connection with the Registration
Statement or the qualification or compliance of the offering; and the Company will reimburse such Selling Stockholder, underwriter and each such controlling person for any legal or any other expenses reasonably incurred by such Selling Stockholder,
underwriter or controlling person in connection with investigating or defending any such loss, claim, damage, liability or action; provided, however, that the Company will not be liable in any such case to the extent that any such
loss, claim, damage or liability arises out of or is based upon any untrue statement or omission made in such Registration Statement, preliminary prospectus or prospectus, or any such amendment or supplement, in reliance upon and in conformity with
information furnished to the Company, in writing, by or on behalf of such Selling Stockholder, underwriter or controlling person specifically for use in the preparation thereof. 

(b) In the event of any registration of any of the Registrable Shares under the Securities Act pursuant to this Agreement, each Selling
Stockholder, severally and not jointly, will indemnify and hold harmless the Company, each of its directors and officers and each underwriter (if any) and each person, if any, who controls the Company or any such underwriter within the meaning of
the Securities Act or the Exchange Act, against any losses, claims, damages or liabilities, joint or several, to which the Company, such directors and officers, underwriter or controlling person may become subject under the Securities Act, Exchange
Act, state securities or Blue Sky laws or otherwise, insofar as such losses, claims, damages or liabilities (or actions in respect thereof) arise out of or are based upon (i) any untrue statement or alleged untrue statement of a material fact
contained in any Registration Statement under which such Registrable Shares were registered under the Securities Act, any preliminary prospectus or final prospectus contained in the Registration Statement, or any amendment or supplement to the
Registration Statement, or (ii) any omission or alleged omission to state a material fact required to be stated therein or necessary to make the statements therein not misleading, in the case of both (i) and (ii) if and to the extent
(and only to the extent) that the statement or omission or alleged omission was made in reliance upon and in conformity with information relating to such Selling Stockholder furnished in writing to the Company by such Selling Stockholder
specifically for use in connection with the preparation of such Registration Statement, prospectus, amendment or supplement; provided, however, that the obligations of a Selling Stockholder hereunder shall be limited to an amount equal
to the net proceeds to such Selling Stockholder of Registrable Shares sold in connection with such registration. 
 (c) Each
Indemnified Party shall give notice to the Indemnifying Party promptly after such Indemnified Party has actual knowledge of any claim as to which indemnity may be sought, and shall permit the Indemnifying Party to assume the defense of any such
claim or any litigation resulting therefrom; provided, that counsel for the Indemnifying Party, who shall conduct the defense of such claim or litigation, shall be approved by the Indemnified Party (whose approval shall not be unreasonably
withheld, conditioned or delayed); and, provided, 

  
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further, that the failure of any Indemnified Party to give notice as provided herein shall not relieve the Indemnifying Party of its obligations under this Section 2.5 except to the
extent that the Indemnifying Party is adversely affected by such failure. The Indemnified Party may participate in such defense at such party’s expense; provided, however, that the Indemnifying Party shall pay such expense if the
Indemnified Party reasonably concludes that representation of such Indemnified Party by the counsel retained by the Indemnifying Party would be inappropriate due to actual or potential differing interests between the Indemnified Party and any other
party represented by such counsel in such proceeding; provided further that in no event shall the Indemnifying Party be required to pay the expenses of more than one law firm per jurisdiction as counsel for the Indemnified Party. The
Indemnifying Party also shall be responsible for the expenses of such defense if the Indemnifying Party does not elect to assume such defense. No Indemnifying Party, in the defense of any such claim or litigation shall, except with the consent of
each Indemnified Party, consent to entry of any judgment or enter into any settlement which does not include as an unconditional term thereof the giving by the claimant or plaintiff to such Indemnified Party of a release from all liability in
respect of such claim or litigation, and no Indemnified Party shall consent to entry of any judgment or settle such claim or litigation without the prior written consent of the Indemnifying Party, which consent shall not be unreasonably withheld,
conditioned or delayed. 
 (d) In order to provide for just and equitable contribution in circumstances in which the
indemnification provided for in this Section 2.5 is due in accordance with its terms but for any reason is held to be unavailable to an Indemnified Party in respect to any losses, claims, damages and liabilities referred to herein, then the
Indemnifying Party shall, in lieu of indemnifying such Indemnified Party, contribute to the amount paid or payable by such Indemnified Party as a result of such losses, claims, damages or liabilities to which such party may be subject in such
proportion as is appropriate to reflect the relative fault of the Company on the one hand and the Selling Stockholders on the other in connection with the statements or omissions which resulted in such losses, claims, damages or liabilities, as well
as any other relevant equitable considerations. The relative fault of the Company and the Selling Stockholders shall be determined by reference to, among other things, whether the untrue or alleged untrue statement of material fact related to
information supplied by the Company or the Selling Stockholders and the parties’ relative intent, knowledge, access to information and opportunity to correct or prevent such statement or omission. The Company and the Selling Stockholders agree
that it would not be just and equitable if contribution pursuant to this Section 2.5(d) were determined by pro rata allocation or by any other method of allocation which does not take account of the equitable considerations referred to above.
Notwithstanding the provisions of this Section 2.5(d), (i) in no case shall any one Selling Stockholder be liable or responsible for any amount in excess of the net proceeds received by such Selling Stockholder from the offering of
Registrable Shares and (ii) the Company shall be liable and responsible for any amount in excess of such proceeds; provided, however, that no person guilty of fraudulent misrepresentation (within the meaning of Section 11(f)
of the Securities Act) shall be entitled to contribution from any person who was not guilty of such fraudulent misrepresentation. Any party entitled to contribution will, promptly after receipt of notice of commencement of any action, suit or
proceeding against such party in respect of which a claim for contribution may be made against another party or parties under this Section 2.5(d), notify such party or parties from whom contribution may be sought, but the omission so to notify
such party or parties from whom 

  
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contribution may be sought shall not relieve such party from any other obligation it or they may have thereunder or otherwise under this Section 2.5(d). No party shall be liable for
contribution with respect to any action, suit, proceeding or claim settled without its prior written consent, which consent shall not be unreasonably withheld, conditioned or delayed. 

(e) The rights and obligations of the Company and the Selling Stockholders under this Section 2.5 shall survive the termination of
this Agreement. 
 2.6 Other Matters with Respect to Underwritten Offerings. In the event that Registrable Shares are
sold pursuant to a Registration Statement in an underwritten offering pursuant to Section 2.1, the Company agrees to (a) enter into an underwriting agreement containing customary representations and warranties with respect to the business
and operations of the Company and customary covenants and agreements to be performed by the Company, including without limitation customary provisions with respect to indemnification by the Company of the underwriters of such offering; (b) use
its best efforts to cause its legal counsel to render customary opinions to the underwriters and the Selling Stockholders with respect to the Registration Statement; and (c) use its best efforts to cause its independent public accounting firm
to issue customary “cold comfort letters” to the underwriters and the Selling Stockholders with respect to the Registration Statement. 
 2.7 Information by Holder. Each holder of Registrable Shares included in any registration shall furnish to the Company such information regarding such holder and the distribution proposed by such
holder as the Company may reasonably request in writing and as shall be required in connection with any registration, qualification or compliance referred to in this Agreement. 

2.8 “Lock-Up” Agreement; Confidentiality of Notices. Each Purchaser agrees, if requested by the Company and the managing
underwriter of the Initial Public Offering, (i) not to (a) offer, pledge, announce the intention to sell, sell, contract to sell, sell any option or contract to purchase, purchase any option or contract to sell, grant any option, right or
warrant to purchase, or otherwise transfer or dispose of, directly or indirectly, any Registrable Shares or other securities of the Company (excluding securities acquired in the Initial Public Offering or in the public market after such offering) or
(b) enter into any swap or other agreement that transfers, in whole or in part, any of the economic consequences of ownership of any Registrable Shares or other securities of the Company (excluding securities acquired in the Initial Public
Offering or in the public market after such offering), whether any transaction described in clause (a) or (b) is to be settled by delivery of securities, in cash or otherwise, during the period beginning on the date of the filing of such
Registration Statement with the Securities and Exchange Commission and ending 180 days after the date of the final prospectus relating to the Initial Public Offering (plus up to an additional 18 days to the extent requested by the managing
underwriters for such offering in order to address NASD Rule 2711(f) of the Financial Industry Regulatory Authority, Inc. or any similar successor provision) and (ii) to execute any agreement reflecting clause (i) above as may be requested
by the Company or the managing underwriters at the time of such offering; provided, that all stockholders of the Company then holding at least 1% of the outstanding Common Stock (on an as-converted basis) and all officers and directors of the
Company enter into similar agreements. The obligations described in this Section 2.8 shall 

  
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not apply to a registration relating solely to employee benefit plans on Form S-l or Form S-8 or similar forms that may be promulgated in the future, or a registration relating solely to a
transaction on Form S-4 or similar forms that may be promulgated in the future. In addition, in the event that the Company or the managing underwriter shall release a party from the obligations of this Section 2.8 (or any other similar
agreement) then each other party bound by such section or similar agreement shall have a proportionate number of shares released from such restrictions. 
 The Company may impose stop-transfer instructions with respect to the Registrable Shares or other securities subject to the foregoing restriction until the end of such “lock-up” period.

 Any Purchaser receiving any written notice from the Company regarding the Company’s plans to file a Registration
Statement shall treat such notice confidentially and shall not disclose such information to any person other than as necessary to exercise its rights under this Agreement. 
 2.9 Limitations on Subsequent Registration Rights. The Company shall not, without the prior written consent of Purchasers holding at least 50.1% of the Registrable Shares then held by all
Purchasers, enter into any agreement (other than this Agreement) with any holder or prospective holder of any securities of the Company which grants such holder or prospective holder rights to include securities of the Company in any Registration
Statement, unless (a) such rights to include securities in a registration initiated by the Company or by Purchasers are not more favorable than the rights granted to Other Holders under Section 2.2, (b) no rights are granted to
initiate a registration, other than registration pursuant to a registration statement on Form S-3 (or its successor) in which Purchasers are entitled to include Registrable Shares on a pro rata basis with such holders based on the number of shares
of Common Stock (on an as-converted basis) owned by Purchasers and such holders and (c) such holder is bound by obligations substantively similar to the obligations of the Holders set forth in Sections 2.4, 2.5, 2.7 and 2.8. 

2.10 Rule 144 Requirements. After the earliest of (i) the closing of the sale of securities of the Company pursuant to a
Registration Statement, (ii) the registration by the Company of a class of securities under Section 12 of the Exchange Act, or (iii) the issuance by the Company of an offering circular pursuant to Regulation A under the Securities
Act, the Company agrees to: 
 (a) make and keep current public information about the Company available, as
those terms are understood and defined in Rule 144; 
 (b) use its best efforts to file with the Commission in a
timely manner all reports and other documents required of the Company under the Securities Act and the Exchange Act (at any time after it has become subject to such reporting requirements); and 

  
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 (c) furnish to any holder of Registrable Shares upon request (i) a
written statement by the Company as to its compliance with the reporting requirements of Rule 144 and of the Securities Act and the Exchange Act (at any time after it has become subject to such reporting requirements), (ii) a copy of the most
recent annual or quarterly report of the Company, and (iii) such other reports and documents of the Company as such holder may reasonably request to avail itself of any similar rule or regulation of the Commission allowing it to sell any such
securities without registration. 
 2.11 Termination. All of the Company’s obligations to register Registrable
Shares under Sections 2.1 and 2.2 shall terminate upon the earliest of (a) seven years after the closing of the Initial Public Offering, (b) the date on which no Purchaser holds any Registrable Shares or (c) a Public Company Sale.

 3. Right of First Refusal. 
 3.1 Rights of Purchasers to Acquire Offered Securities. 
 (a) The Company
shall not issue, sell or exchange, agree to issue, sell or exchange, or reserve or set aside for issuance, sale or exchange, any Offered Securities, unless in each such case the Company shall have first complied with this Section 3.1. The
Company shall deliver to each Major Purchaser an Offer, which shall (i) identify and describe the Offered Securities, (ii) describe the price and other terms upon which they are to be issued, sold or exchanged, and the number or amount of
the Offered Securities to be issued, sold or exchanged, (iii) identify the persons or entities (if known) to which or with which the Offered Securities are to be offered, issued, sold or exchanged, and (iv) offer to issue and sell to or
exchange with such Major Purchaser that is a Qualified Purchaser (A) such Qualified Purchaser’s Basic Amount and (B) such Qualified Purchaser’s Undersubscription Amount. Notwithstanding the other provisions of this
Section 3.1, after delivery of the Offer, the Company may issue, sell or exchange, agree to issue, sell or exchange, or reserve or set aside for issuance, sale or exchange, Offered Securities to the offerees or purchasers described in the Offer
and upon the terms and conditions (including, without limitation, unit prices and interest rates) set forth in the Offer without complying with the time periods in subsection (b) of this Section 3.1, provided that the Company permits each
Qualified Purchaser to purchase the maximum number of Offered Securities that such Qualified Purchaser would be entitled to purchase pursuant to this Section 3.1 on substantially the same terms as the Company sold the Offered Securities in the
initial transaction, within 10 days after the Company receives a Notice of Acceptance from such Qualified Purchaser. 
 (b) To
accept an Offer, in whole or in part, a Qualified Purchaser must deliver to the Company, on or prior to the date 15 days after the date of delivery of the Offer, a Notice of Acceptance providing a representation letter certifying that such Qualified
Purchaser is an accredited investor within the meaning of Rule 501 under the Securities Act and indicating the portion of the Qualified Purchaser’s Basic Amount that such Qualified Purchaser elects to purchase and, if such Qualified Purchaser
shall elect to purchase all of its Basic Amount, the Undersubscription Amount (if any) that such Qualified Purchaser elects to purchase. If the Basic Amounts subscribed for by all Qualified Purchasers are less than the total of all of the Basic
Amounts available for purchase, then each Qualified Purchaser who has set forth an Undersubscription Amount in its Notice of Acceptance shall be entitled to purchase, in addition 

  
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to the Basic Amounts subscribed for, the Undersubscription Amount it has subscribed for; provided, however, that if the Undersubscription Amounts subscribed for exceed the Available
Undersubscription Amount, each Qualified Purchaser who has subscribed for any Undersubscription Amount shall be entitled to purchase only that portion of the Available Undersubscription Amount as the Undersubscription Amount subscribed for by such
Qualified Purchaser bears to the total Undersubscription Amounts subscribed for by all Purchasers, subject to rounding by the Board of Directors to the extent it deems reasonably necessary. 

(c) The Company shall have 90 days from the expiration of the period set forth in Section 3.1(b) to issue, sell or exchange all or
any part of the Refused Securities, but only to the offerees or purchasers described in the Offer (if so described therein) and only upon terms and conditions (including, without limitation, unit prices and interest rates) which are not more
favorable, in the aggregate, to the acquiring person or persons or less favorable to the Company than those set forth in the Offer. 
 (d) In the event the Company shall propose to sell less than all the Refused Securities, then each Qualified Purchaser may, at its sole option and in its sole discretion, reduce the number or amount of
the Offered Securities specified in its Notice of Acceptance to an amount that shall be not less than the number or amount of the Offered Securities that the Qualified Purchaser elected to purchase pursuant to Section 3.1(b) multiplied by a
fraction, (i) the numerator of which shall be the number or amount of Offered Securities the Company actually proposes to issue, sell or exchange (including Offered Securities to be issued or sold to Qualified Purchasers pursuant to
Section 3.1(b) prior to such reduction) and (ii) the denominator of which shall be the original amount of the Offered Securities. In the event that any Qualified Purchaser so elects to reduce the number or amount of Offered Securities
specified in its Notice of Acceptance, the Company may not issue, sell or exchange more than the reduced number or amount of the Offered Securities unless and until such securities have again been offered to the Qualified Purchasers in accordance
with Section 3.1(a). 
 (e) Upon (i) the closing of the issuance, sale or exchange of all or less than all of the
Refused Securities or (ii) such other date agreed to by the Company and Qualified Purchasers who have subscribed for a majority of the Offered Securities subscribed for by the Qualified Purchasers, such Qualified Purchaser or Purchasers shall
acquire from the Company and the Company shall issue to such Qualified Purchaser or Purchasers, the number or amount of Offered Securities specified in the Notices of Acceptance, as reduced pursuant to Section 3.1(d) if any of the Qualified
Purchasers has so elected, upon the terms and conditions specified in the Offer. 
 (f) The purchase by the Qualified
Purchasers of any Offered Securities is subject in all cases to the preparation, execution and delivery by the Company and the Qualified Purchasers of a purchase agreement and other ancillary agreements relating to such Offered Securities reasonably
satisfactory in form and substance to the Qualified Purchasers and their respective counsel. 

  
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 (g) Any Offered Securities not acquired by the Qualified Purchasers or other persons in
accordance with Section 3.1(c) may not be issued, sold or exchanged until they are again offered to the Qualified Purchasers under the procedures specified in this Agreement. 

(h) The rights of the Qualified Purchasers under this Section 3.1 shall not apply to: 

(i) the issuance of any shares of Common Stock as a stock dividend to holders of Common Stock or upon any subdivision or combination of
shares of Common Stock; 
 (ii) the issuance of securities as a dividend or distribution on shares of Preferred Stock
(including the Shares); 
 (iii) the issuance of any shares of Common Stock upon conversion of shares of the Preferred Stock;

 (iv) the issuance of shares of Common Stock or options with respect thereto (subject in either case to appropriate
adjustment for stock splits, stock dividends, recapitalizations and similar events occurring after the date of this Agreement), issued or issuable to employees, directors or officers of, or consultants to, the Company or any Company Subsidiary
pursuant to the 2008 Equity Incentive Plan or any other plan, agreement or arrangement approved by the Board of Directors of the Company; 
 (v) the issuance of securities pursuant to the bona fide acquisition of another corporation by the Company or any Company Subsidiary by merger, purchase of substantially all of the assets or other
reorganization or to any joint venture agreement provided that such issuance is approved by the Board of Directors; 
 (vi) the
issuance of shares of Common Stock by the Company in a Qualified Public Offering (as such term is defined in the Company’s Amended and Restated Certificate of Incorporation) or a public offering prior to or in connection with which all
Preferred Stock is converted to Common Stock; 
 (vii) the issuance of shares of Common Stock, or the grant of options or
warrants therefor, to banks, equipment lessors or other financial institutions, or to real property lessors, pursuant to non-convertible a debt financing, equipment leasing or real property leasing transaction provided such issuance is approved by
the Board of Directors; 
 (viii) the issuance of securities issued in connection with sponsored research, collaboration,
technology license, development, marketing or other similar agreements or strategic partnerships, provided, that such issuance is approved by the Board of Directors; or 

(ix) the issuance of securities in connection with a transaction approved by holders of at least 50.1% of the outstanding shares of
Preferred Stock voting together as a single class on an as-converted to Common Stock basis. 

  
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 3.2 Termination. This Section 3 shall terminate upon the earlier of the closing
of a Public Company Sale or the closing of a public offering prior to or in connection with which all Preferred Stock converts to Common Stock. 
 4. Covenants. 
 4.1 Negative Covenants. So long as any Shares are
outstanding, the Company shall not, without approval of the Board of Directors: 
 (a) create any Company Subsidiary;

 (b) enter into, or permit any Company Subsidiary to enter into, any lines of business that are not primarily related to the
business of the Company as conducted or proposed to be conducted as of the date of this Agreement; 
 (c) make any capital
expenditures in any fiscal quarter (including expenditures for capitalized leases and capital expenditures by Company Subsidiaries) in excess of those provided for with respect to such fiscal quarter in the budget duly adopted by the Board of
Directors, without the approval of the Board of Directors of the Company and a majority of the Preferred Directors; 
 (d)
issue any equity securities (other than options, restricted stock or other awards issued to employees, consultants, or directors in accordance with the 2008 Equity Incentive Plan or any other equity incentive or stock option plan approved by the
Board of Directors of the Company and by a majority of the Preferred Directors); 
 (e) make any loan or advance to, or acquire
any stock or other securities of, or permit any Company Subsidiary to make any loan or advance to, or acquire any stock or other securities of, any entity unless it is wholly owned by the Company; 

(f) make, or permit any Company Subsidiary to make, any loan or advance to any person, including, without limitation, any employee or
director of the Company or any Company Subsidiary, except advances and similar expenditures in the ordinary course of business or under the terms of an employee stock or option plan approved by the Board of Directors of the Company and by a majority
of the Preferred Directors; 
 (g) guarantee, or permit any Company Subsidiary to guarantee, directly or indirectly, any
indebtedness or obligations except for trade accounts of any Company Subsidiary arising in the ordinary course of business; or 

(h) amend or modify any stock option plan, or any transfer, vesting or repurchase provisions of any restricted stock or option agreement
to provide the other party thereto with more favorable provisions with respect to vesting, repurchase or transfer. 

  
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 4.2 Affirmative Covenants. So long as any Shares are outstanding, the Company
covenants and agrees that it will perform and observe the following covenants and provisions and will cause each Company Subsidiary to perform and observe such of the following covenants and provisions as are applicable to such Company Subsidiary:

 (a) Payment of Taxes and Trade Debt. Pay and discharge all taxes, assessments and governmental charges or levies
imposed upon it or upon its income or profits or business, or upon any properties belonging to it, prior to the date on which penalties attach thereto, and all lawful claims, which, if unpaid, might become a lien or charge upon any properties of the
Company or a Company Subsidiary, other than those which are being contested in good faith if the Company shall have set aside on its books and shall have provided, in accordance with generally accepted accounting principles, adequate reserves with
respect thereto; and pay in conformity with customary trade terms, all lease obligations, all trade debt, and all other indebtedness incident to its operations, except such as are being contested in good faith if the Company shall have set aside on
its books and shall have provided, in accordance with generally accepted accounting principles, appropriate reserves with respect thereto. 
 (b) Maintenance of Insurance. Maintain with responsible and reputable insurance companies or associations, insurance, including without limitation the directors and officers insurance described in
Section 4.6, in such amounts and covering such risks as the Company reasonably deems advisable. 
 (c) Preservation of
Corporate Existence. Preserve and maintain its corporate existence, rights, franchises and privileges in the jurisdiction of its incorporation, and qualify and remain qualified as a foreign corporation in each jurisdiction in which such
qualification is required, unless the failure to so qualify does not and will not have a material and adverse effect on the business, operations or financial condition of the Company; and preserve and maintain all material licenses and other rights
to use patents, processes, licenses, trademarks, trade names, inventions, intellectual property rights or copyrights owned or possessed by it as are reasonably necessary or advisable for it to conduct its business. 

(d) Compliance with Laws. Comply with all applicable laws, rules, regulations and orders of any governmental authority,
noncompliance with which could materially adversely affect its business or condition, financial or otherwise, except non-compliance being contested in good faith through appropriate proceedings so long as the Company shall have set up and funded
sufficient reserves, if any, required under generally accepted accounting principles with respect to such items. 
 (e)
Keeping of Records and Books of Account. Keep adequate records and books of account, in which complete entries will be made in accordance with generally accepted accounting principles consistently applied, reflecting all financial
transactions of the Company, and in which, for each fiscal year, all proper reserves for depreciation, depletion, obsolescence, amortization, taxes, bad debts and other purposes in connection within its business shall be made. 

(f) Maintenance of Properties, etc. Maintain and preserve all of its properties that the Company reasonably deems necessary or
useful in the proper conduct of its business in good repair, working order and condition, ordinary wear and tear excepted, and from time to time make all necessary and proper repairs, renewals, replacements, additions and improvements thereto; and
comply with the provisions of all material leases to which it is a party or under which it occupies property so as to prevent any material loss or forfeiture thereof or thereunder. 

  
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 4.3 Inspection and Observation. 

(a) The Company shall permit each Major Purchaser, or any authorized representative thereof, to visit and inspect the properties of the
Company, including its corporate and financial records, and to discuss its business and finances with officers of the Company, during normal business hours following reasonable notice and as often as may be reasonably requested; provided,
however, that the Company shall not be obligated pursuant to this Section 4.3(a) to provide access to any information which it reasonably considers to be a trade secret. 

(b) The Company shall invite a representative of Bay City Capital Fund V, L.P., MPM BioVentures IV-QP, L.P., KPCB Holdings, Inc. and New
Enterprise Associates 13, Limited Partnership to attend all meetings of its Board of Directors in a nonvoting observer capacity and, in this respect, shall give such representative copies of all notices, minutes, consents, and other materials that
it provides to its directors. 
 (c) Notwithstanding the provisions of the foregoing paragraph (b), the Company (i) may
condition the right of any such representatives to attend meetings of the Board of Directors and receive notice and other information with respect to such meetings on the execution of a confidentiality agreement reasonably acceptable to the Company,
(ii) may prevent such representatives from attending a meeting of the Board of Directors (or portion thereof) or receiving certain information with respect thereto if (A) the Company believes, based upon the advice of the Company’s
legal counsel, that it is reasonably necessary to do so to ensure preservation of the attorney-client privilege (B) the Company believes that it is necessary to protect any trade secrets, highly confidential or proprietary information of the
Company, or (C) a majority of the directors present at such meeting reasonably conclude that a real or potential conflict of interest exists or could exist between the Company and/or any of its existing or potential affiliates or business
partners, and any such observer or the Purchaser designating such observer or any of their respective affiliates or business partners with regard to any subject matter to be discussed at such meeting or portion thereof. 

4.4 Financial Statements and Other Information. 
 (a) So long as any Shares are outstanding, the Company shall deliver to each Major Purchaser: 
 (i) within 120 days after the end of each fiscal year of the Company commencing with the fiscal year ended December 31, 2011, an audited balance sheet of the Company as at the end of such year
and audited statements of income and of cash flows of the Company for such year, certified by certified public accountants of established national reputation selected by the Company (or as otherwise approved by the Board of Directors), and prepared
in accordance with generally accepted accounting principles consistently applied; 

  
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 (ii) within 30 days after the end of each fiscal quarter of the Company (other than the
fourth quarter), an unaudited balance sheet of the Company as at the end of such quarter, and unaudited statements of income and of cash flows of the Company for such fiscal quarter and for the current fiscal year to the end of such fiscal quarter,
setting forth in comparative form the Company’s projected financial statements for the corresponding periods for the current fiscal year; 
 (iii) within 30 days after the end of each month (other than the last month of any fiscal quarter), an unaudited balance sheet of the Company as at the end of such month and unaudited statements of income
and of cash flows of the Company for such month and for the current fiscal year to the end of such month, setting forth in comparative form the Company’s projected financial statements for the corresponding periods for the current fiscal year;

 (iv) as soon as available, but in any event at least 10 days prior to the commencement of each new fiscal year, a business
plan and projected financial statements for such fiscal year; 
 (v) such other notices, information and data with respect to
the Company as the Company delivers to the holders of its capital stock at the same time it delivers such items to such holders; and 
 (vi) with reasonable promptness, such other information and data as such Major Purchaser may from time to time reasonably request. 

(b) The foregoing financial statements shall be prepared on a consolidated basis if the Company then has any subsidiaries. The financial
statements delivered pursuant to clause (ii) and clause (iii) of paragraph (a) shall be accompanied by a certificate of the chief financial officer of the Company stating on behalf of the Company that such statements have been
prepared in accordance with generally accepted accounting principles consistently applied (except as noted) and fairly present the financial condition and results of operations of the Company at the date thereof and for the periods covered thereby.

 (c) The Company shall provide prompt notice to New Enterprise Associates 13, Limited Partnership (“NEA 13”)
following any “determination date” (as defined in Treasury Regulation Section 1.897-2(c)(1)) on which the Company becomes a United States real property holding corporation. In addition, upon a written request by NEA 13, the
Company shall provide NEA 13 with a written statement informing NEA 13 whether NEA 13’s interest in the Company constitutes a United States real property interest. The Company’s determination shall comply with the
requirements of Treasury Regulation Section 1.897-2(h)(1) or any successor regulation, and the Company shall provide timely notice to the Internal Revenue Service, in accordance with and to the extent required by Treasury Regulation
Section 1.897-2(h)(2) or any successor regulation, that such statement has been made. The Company’s written statement to NEA 13 shall be delivered to NEA 13 within 10 days of NEA 13’s written request therefor.
Notwithstanding Section 4.13 hereof, the Company’s obligation to furnish such written statement shall continue notwithstanding the fact that a class of the Company’s stock may be regularly traded on an established securities market or
the fact that there is no preferred stock then outstanding. 

  
 -22-









 (d) The Company shall submit to the Internal Revenue Service any reports that may be
required under Section 1202(d)(1)(C) of the Code and the related Treasury Regulations. In addition, within a commercially reasonable time after any Purchaser has delivered to the Company a written request therefor, the Company shall deliver to
such Purchaser a written statement indicating whether, to the knowledge of the Company, such Purchaser’s interest in the Company constitutes “qualified small business stock” as defined in Section 1202(c) of the Code, or, at the
election of the Company, a written statement containing such factual information available to the Company as may be reasonably required by the Purchaser to permit the Purchaser or the Purchaser’s advisors to determine whether the
Purchaser’s interest in the Company constitutes “qualified small business stock” as defined in Section 1202(c) of the Code. 
 4.5 Material Changes and Litigation. The Company shall promptly notify the Purchasers of any material adverse change in the business, prospects, assets or condition, financial or otherwise, of the
Company and of any litigation or governmental proceeding or investigation brought or, to the Company’s knowledge, threatened against the Company, or against any officer, director, key employee or principal stockholder of the Company which, if
adversely determined, would have a material adverse effect on the business, prospects, assets or condition (financial or otherwise) of the Company. 
 4.6 D&O Insurance. The Company shall maintain directors and officers’ liability insurance in an amount and with coverage approved by the Board of Directors. 

4.7 Agreements with Employees; Options. 
 (a) The Company shall require (i) all persons now or hereafter (A) serving on its scientific advisory board, (B) employed by the Company or (C) serving as an officer of the Company to
enter into non-disclosure and assignment of inventions agreements substantially in the form delivered to counsel to the Purchasers (or, in the case of an officer or other individual who is a consultant or member of its scientific advisory board
(“SAB”), a consulting agreement or SAB agreement containing substantially similar provisions with respect to confidentiality and invention assignment), (ii) all independent contractors utilized by the Company who have access to
confidential or proprietary information of the Company to enter into non-disclosure and assignment of inventions agreements and (iii) all officers and key employees of the Company to enter into non-competition and non-solicitation agreements
substantially in the form delivered to counsel to the Purchasers, or such other form as may be approved by the Board of Directors. 
 (b) The Company agrees that it will not, without the approval of the Board of Directors, terminate, amend or waive any rights under any inventions, confidentiality, non-competition or restricted stock
agreement between the Company and any member of the Company’s scientific advisory board. 

  
 -23-









 (c) Unless otherwise approved by the Board of Directors, all options, restricted stock or
other stock awards (including without limitation restricted stock units or SARs) granted or issued by the Company after the date hereof shall become exercisable at the rate of 25% on the first anniversary of grant or issue and 2.083% per month
thereafter over the subsequent three years so long as the holder continues to be an employee or consultant of the Company. 

4.8 Board of Directors. 
 (a) The Company shall promptly reimburse in full each director of the Company who is not an employee of the Company and each observer (under Section 4.3(b) and (c)) for all of his or her reasonable
out-of-pocket expenses incurred in attending each meeting of the Board of Directors of the Company or any committee thereof. 

(b) The Board of Directors shall meet on at least a quarterly basis, unless otherwise agreed by a majority of the Preferred Directors.

 (c) The Company’s Amended and Restated Certificate of Incorporation shall at all times provide for the indemnification
of the members of the Board of Directors to the fullest extent provided by the law of the jurisdiction in which the Company is organized. In the event that the Company or any of its successors or assigns (i) consolidates with or merges into any
other entity and shall not be the continuing or surviving corporation in such consolidation or merger or (ii) transfers or conveys all or substantially all of its properties and assets to any entity, then, and in each such case, to the extent
necessary, proper provision shall be made so that the successors and assigns of the Company assume the obligations of the Company with respect to indemnification of members of the Board of Directors as contained in the Company’s Certificate of
Incorporation and its directors and officers’ insurance policy. 
 4.9 Related Party Transactions. 

(a) The Company shall not enter into any agreement with any stockholder, officer or director of the Company, or any “affiliate”
of such persons (as such term is defined in the rules and regulations promulgated under the Securities Act), including without limitation any agreement or other arrangement providing for the furnishing of services by, rental of real or personal
property from, or otherwise requiring payments to (but excluding any agreements with respect to investments for cash in a bona fide financing), any such person or entity, without the consent of a majority of the members of the Company’s Board
of Directors having no interest in such agreement or arrangement. 
 (b) The approval of the Board of Directors of the Company
and a majority of Preferred Directors shall be required to (i) establish or increase the compensation of executive officers of the Company or (ii) grant stock options to any officer of the Company. 

4.10 Reservation of Common Stock. The Company shall reserve and maintain a sufficient number of shares of Common Stock for
issuance upon conversion of all of the outstanding Shares. 

  
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 4.11 International Investment and Trade in Services Survey Act. The Company shall use
its best efforts to file on a timely basis all reports required to be filed by it under 22 U.S.C. Section 3104, or any similar statute, relating to a foreign person’s direct or indirect investment in the Company. 

4.12 Market Stand-Off Agreement with Future Security Holders; Right of First Refusal. Unless otherwise approved by the Purchasers
who then are holders in interest of at least 50.1% of the then outstanding Shares, (i) the Company shall cause each future holder of its securities to enter into an agreement substantially similar to the market stand-off agreement set forth in
Section 2.8 hereof and (ii) the Company will assign to the Major Purchasers any contractual right of first refusal it has to purchase shares of Common Stock from its stockholders that it elects not to exercise with such assignment being
allocated to the Major Purchasers in accordance with the mechanism by which such shares would have been allocated pursuant to the Amended and Restated Right of First Refusal and Co-Sale Agreement dated of even date herewith by and among the Company,
the Purchasers and the Key Holders party thereto. Notwithstanding clause (ii), the Major Purchasers acknowledge that the Company may not be able to assign its right to repurchase shares of Common Stock from stockholders who are subject to stock
ownership policies of the Howard Hughes Medical Institute, whose ownership exceeds the 5% stock ownership policy of the Howard Hughes Medical Institute and whose agreements with the Company require transfers by such stockholders to the Company
(either voluntarily or upon the Company’s exercise of a repurchase right) in order to ensure that such stockholders become compliant with such stock ownership policies. 
 4.13 Termination of Covenants. Other than the covenant contained in Section 4.11, all covenants of the Company contained in this Section 4 shall terminate upon the earlier of the closing
of a Public Company Sale or the closing of an Initial Public Offering in which all Preferred Stock converts to Common Stock. 

5. Confidentiality. Each Purchaser agrees that he, she or it will keep confidential and will not disclose, divulge or use for any
purpose, other than to monitor its investment in the Company, any Confidential Information, unless such Confidential Information (a) is known or becomes known to the public in general (other than as a result of a breach of this Section 5
by such Purchaser), (b) is or has been independently developed or conceived by the Purchaser without use of the Company’s Confidential Information or (c) is or has been made known or disclosed to the Purchaser by a third party without
a breach of any obligation of confidentiality such third party may have to the Company; provided, however, that a Purchaser may disclose Confidential Information (i) to its attorneys, accountants, consultants, and other
professionals to the extent necessary to obtain their services in connection with monitoring its investment in the Company, (ii) to any prospective purchaser of any Shares from such Purchaser as long as such prospective purchaser agrees to be
bound by the provisions of this Section 5, (iii) to any Affiliated Party of such Purchaser provided that such party is obligated not to disclose, divulge or use any Confidential Information to the same extent as the Purchaser, or
(iv) as may otherwise be required by law, provided that the Purchaser takes reasonable steps to minimize the extent of any such required disclosure. Notwithstanding the foregoing, such information shall not be deemed confidential for the
purpose of enforcing this Agreement. To the extent that any Purchaser is party to an agreement with the Company that governs confidential information provided by the Company to such Investor and/or its Affiliated Parties under this Agreement and/or
with respect to Board observer rights, the provisions of such agreement shall apply in lieu of the foregoing. 

  
 -25-









 6. Transfers of Rights; Calculation of Share Numbers. 

6.1 Transfer of Rights. This Agreement, and the rights and obligations of each Purchaser hereunder, may be assigned by such
Purchaser to (a) any person or entity to which at least 500,000 Shares (subject to appropriate adjustment for stock splits, stock dividends, recapitalizations and similar events occurring after the date of this Agreement) are transferred by
such Purchaser, or (b) to any Affiliated Party of such Purchaser, and, in each case, such transferee shall be deemed a “Purchaser” for purposes of this Agreement; provided that such assignment of rights shall be contingent upon the
transferee providing a written instrument to the Company notifying the Company of such transfer and assignment and agreeing in writing to be bound by the terms of this Agreement. Notwithstanding the foregoing, any person or entity to which any
Shares or Registrable Shares are transferred by a Purchaser, whether voluntarily or by operation of law, shall be bound by the obligations under Section 2.8 to the same extent as if such transferee were a Purchaser hereunder and no Purchaser
shall transfer any Shares or Registrable Shares unless the transferee provides a written instrument to the Company notifying the Company of such transfer and agreeing in writing to be bound by the terms of Section 2.8. 

6.2 Calculation of Share Numbers. In determining the number of Shares owned by a Purchaser for purposes of exercising rights under
this Agreement, (a) Shares owned by a Purchaser shall be deemed to include Shares which have been converted into Common Stock so long as such Common Stock is owned by such Purchaser and (b) all Shares held by Affiliated Parties shall be
aggregated together (provided that no shares shall be attributed to more than one entity or person within any such group of Affiliated Parties). 
 7. General. 
 7.1 Severability. The invalidity or unenforceability
of any provision of this Agreement shall not affect the validity or enforceability of any other provision of this Agreement. 

7.2 Specific Performance. In addition to any and all other remedies that may be available at law in the event of any breach of
this Agreement, each Purchaser shall be entitled to specific performance of the agreements and obligations of the Company hereunder and to such other injunctive or other equitable relief as may be granted by a court of competent jurisdiction.

 7.3 Governing Law. This Agreement shall be governed by and construed in accordance with the General Corporation Law of
the State of Delaware, as to matters within the scope thereof, and the internal laws of the Commonwealth of Massachusetts (without reference to the conflicts of law provisions thereof), as to all other matters. 

7.4 Notices. All notices, requests, consents and other communications under this Agreement shall be in writing and shall be deemed
delivered (i) three business days after being sent by registered or certified mail, return receipt requested, postage prepaid or (ii) one business day after being sent via a reputable nationwide overnight courier service guaranteeing next
business day delivery, in each case to the intended recipient as set forth below: 

  
 -26-









 If to the Company, at 325 Vassar Street, Cambridge, MA 02139, Attention: Chief Executive
Officer, or at such other address as may have been furnished in writing by the Company to the other parties hereto, with a copy to Wilmer Cutler Pickering Hale and Dorr LLP, 60 State Street, Boston, MA 02109, Attention: Rosemary G. Reilly, Esq.;

 If to a Purchaser, at its address set forth on Exhibit A, or at such other address as may have been furnished in
writing by such Purchaser to the other parties hereto. 
 Any party may give any notice, request, consent or other communication
under this Agreement using any other means (including, without limitation, personal delivery, messenger service, telecopy, first class mail or electronic mail) addressed as set forth on Exhibit A hereto or such other address as may have been
furnished in writing by a party to the other parties hereto, but no such notice, request, consent or other communication shall be deemed to have been duly given unless and until it is actually received by the party for whom it is intended. Any party
may change the address to which notices, requests, consents or other communications hereunder are to be delivered by giving the other parties notice in the manner set forth in this Section 7.4. 

7.5 Complete Agreement. This Agreement constitutes the entire agreement and understanding of the parties hereto with respect to
the subject matter hereof and supersedes all prior agreements and understandings relating to such subject matter. 
 7.6
Amendments and Waivers. This Agreement may be amended or terminated and the observance of any term of this Agreement may be waived with respect to all parties to this Agreement (either generally or in a particular instance and either
retroactively or prospectively), with the written consent of the Company and Purchasers holding Shares representing at least 50.1% of the voting power of all Shares then held by Purchasers; provided that any amendment, termination or waiver to the
terms of Section 2 (or a defined term used therein) that occurs after the closing of the Initial Public Offering shall instead require the written consent of the Company and Purchasers holding Registrable Shares representing at least 50.1% of
the voting power of all Registrable Shares then held by all Purchasers. Notwithstanding the foregoing, 
 (a) this Agreement may
not be amended or terminated and the observance of any term hereunder may not be waived with respect to any Purchaser without the written consent of such Purchaser unless such amendment, termination or waiver applies to all Purchasers in the same
fashion (it being agreed that a waiver of the provisions of Section 3 with respect to a particular transaction shall be deemed to apply to all Qualified Purchasers in the same fashion if such waiver does so by its terms, notwithstanding the
fact that certain Qualified Purchasers may nonetheless, by agreement with the Company, purchase securities in such transaction); and 
 (b) the definition of “Major Purchaser” shall not be amended in a manner that materially adversely impacts any Major Purchaser (and no such other action taken shall be taken hereunder that has
the effect thereof) without the consent of such Major Purchaser 

  
 -27-









 
so long as at the time of such amendment such Major Purchaser holds at least 1% of the outstanding capital stock of the Company (taken on an as-converted to common stock basis), provided, that in
the event such Major Purchaser subsequently falls below such 1% threshold, such Purchaser shall continue to be considered a Major Purchaser so long as it holds enough Shares to be deemed a Major Purchaser as determined at the time such shares were
acquired, but in no event holds less than 75% of the Shares originally purchased by such Purchaser. 
 The Company shall give
prompt written notice of any amendment or termination hereof or waiver hereunder to any party hereto that did not consent in writing to such amendment, termination or waiver. Any amendment, termination or waiver effected in accordance with this
Section 7.6 shall be binding on all parties hereto, even if they do not execute such consent. No waivers of or exceptions to any term, condition or provision of this Agreement, in any one or more instances, shall be deemed to be, or construed
as, a further or continuing waiver of any such term, condition or provision. 
 7.7 Amendment and Restatement of Prior
Agreement. Upon execution of this Agreement by the Company and Purchasers (as defined in the Prior Investor Rights Agreement) holding Shares (as defined in the Prior Investor Rights Agreement) representing at least 62% of the voting power of all
Shares (as defined in the Prior Investor Rights Agreement), the Prior Investor Rights Agreement shall be amended and restated to read in its entirety as set forth herein. 
 7.8 Pronouns. Whenever the context may require, any pronouns used in this Agreement shall include the corresponding masculine, feminine or neuter forms, and the singular form of nouns and pronouns
shall include the plural, and vice versa. 
 7.9 Counterparts; Facsimile Signatures. This Agreement may be executed in
any number of counterparts, each of which shall be deemed to be an original, and all of which together shall constitute one and the same document. This Agreement may be executed by facsimile signatures. 

7.10 Section Headings and References. The section headings are for the convenience of the parties and in no way alter, modify,
amend, limit or restrict the contractual obligations of the parties. Any reference in this agreement to a particular section or subsection shall refer to a section or subsection of this Agreement, unless specified otherwise. 

  
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 Executed as of the date first written above. 

 

			
	EPIZYME, INC.
		
	By:	 	/s/ Robert J. Gould
		 	 Robert J. Gould
 President
and Chief Executive Officer

	
	 
	BRUCE CHABNER
	
	 
	GEORGE DALEY
	
	 
	RON EVANS
	
	/s/ Robert Horvitz
	ROBERT HORVITZ
	
	AMGEN VENTURES LLC
		
	By:	 	 
		
	Name:	 	 
		
	Title:	 	 
	
	ASTELLAS VENTURE FUND I LP
	
	By: Astellas Venture Management LLC
	
	Its: General Partner
		
	By:	 	 
		
	Its:	 	 


 [Signature Page to Amended and Restated Investor Rights Agreement] 








			
	 BAY CITY CAPITAL FUND V, L.P.

	
	By: Bay City Capital Management V LLC, its General Partner
	
	By: Bay City Capital LLC, its Manager
		
	By:	 	/s/ Carl Goldfischer
		
	Name:	 	Carl Goldfischer
		
	Title:	 	Managing Partner
	
	BAY CITY CAPITAL FUND V CO-INVESTMENT FUND, L.P.
	
	By: Bay City Capital Management V LLC, its General Partner
	
	By: Bay City Capital LLC, its Manager
		
	By:	 	/s/ Carl Goldfischer
		
	Name:	 	Carl Goldfischer
		
	Title:	 	Managing Partner
	
	CELGENE EUROPEAN INVESTMENT COMPANY LLC
		
	By:	 	/s/ Robert J. Hugin
		
	Name:	 	Robert J. Hugin
		 	Managing Officer, Celgene International Sarl, for and
	Title:	 	on behalf of Celgene European Investment Company LLC
	
	KPCB HOLDINGS, INC., as Nominee
		
	By:	 	/s/ Eric Keller
		
	Name:	 	Eric Keller
		
	Title:	 	President



  
 [Signature
Page to Amended and Restated Investor Rights Agreement] 








 
			
	
	MPM BIOVENTURES IV-QP, L.P.
	
	By: MPM BIOVENTURES IV GP LLC, its General Partner
	
	By: MPM BIOVENTURES IV LLC, its Managing Member
		
	By:	 	/s/ Ansbert Gadicke
	Name:	 	Ansbert Gadicke
	Title:	 	Member
	
	MPM BIOVENTURES IV GMBH & CO.
	BETEILIGUNGS KG
	
	By: MPM BIOVENTURES IV GP LLC, in its capacity as the Managing Limited Partner
	
	By: MPM BIOVENTURES IV LLC, its Managing Member
		
	By:	 	/s/ Ansbert Gadicke
	Name:	 	Ansbert Gadicke
	Title:	 	Member
	
	MPM ASSET MANAGEMENT INVESTORS BV4 LLC
	
	By: MPM BIOVENTURES IV, LLC, its Manager
		
	By:	 	/s/ Ansbert Gadicke
	Name:	 	Ansbert Gadicke
	Title:	 	Member
	
	MPM BIOVENTURES IV STRATEGIC FUND, L.P.
	
	By: MPM BIOVENTURES IV GP LLC, its General Partner
	
	By: MPM BIOVENTURES IV LLC, its Managing Member
		
	By:	 	/s/ Ansbert Gadicke
	Name:	 	Ansbert Gadicke
	Title:	 	Member



  
 [Signature
Page to Amended and Restated Investor Rights Agreement] 








 
			
	NEW ENTERPRISE ASSOCIATES 13, LIMITED PARTNERSHIP
	By: NEA Partners 13, Limited Partnership, its general partner
	By: NEA 13 GP, LTD, its general partner
		
	By:	 	/s/ Louis S. Citron
		
	Name:	 	Louis S. Citron
		
	Title:	 	Chief Legal Officer
	
	NEA VENTURES 2009, LIMITED PARTNERSHIP
		
	By:	 	/s/ Louis S. Citron
		 	its Vice-President



  
 [Signature
Page to Amended and Restated Investor Rights Agreement] 








 Exhibit A 

List of Purchasers 

Name and Address 
 Amgen Ventures LLC

 One Amgen Center Drive 
 Thousand
Oaks, California 91320 
 Attn: Janice Naeve and Michael Mayes 
 Fax: (805) 499-6751 
 Email: jnaeve@amgen.com 

            mmayes@amgen.com 
 Astellas Venture Fund I LP 
 2882 Sand Hill Road, Suite 121 

Menlo Park, CA 94025 
 Attn: Mr. Sakae
Asanuma 
 Bay City Capital Fund V, L.P. 
 Bay City Capital Fund V Co-Investment Fund, L.P. 
 750 Battery Street 

Suite 400 
 San Francisco, CA 94111 

Celgene European Investment Company LLC 
 Route
de Perreux 1 
 2017 Boudry 

Switzerland 
 KPCB Holdings, Inc. 

2750 Sand Hill Road 
 Menlo Park, CA 94025

 MPM BioVentures IV-QP, L.P. 
 MPM
BioVentures IV GmbH & Co. Beteiligungs KG 
 MPM Asset Management Investors BV4 LLC 

MPM BioVentures IV Strategic Fund, L.P. 
 c/o MPM
Capital 
 The John Hancock Tower 
 200
Clarendon Street, 54th Floor 
 Boston, MA 02116 
 New Enterprise Associates 13, Limited Partnership 
 NEA Ventures 2009, Limited Partnership

 1954 Greenspring Drive 
 Suite 600

 Timonium, MD 21093 
 Attention: David
Mott and Louis Citron 







 Dr. Bruce Chabner 
 29 Beacon Heights Drive 
 Newton, Massachusetts 02459 

Dr. George Daley 
 50 Young Road

 Weston, Massachusetts 02493 

Dr. Ronald M. Evans 
 1471 Cottontail
Lane 
 La Jolla, California 92037 

Dr. H. Robert Horvitz 
 34 Pilgrim Road

 Wellesley, Massachusetts 02481