Support Documents for 

Significant New Use Rule (SNUR) on 

Premanufacture Notice (PMN) 

P-00-1108 

EPA Docket EPA-HQ-OPPT-2011-0577 

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Index

A-001 Structure Activity Team (SAT) Report for 

PMN P-00-1108 

A-002 Initial Review Engineering Report for 

PMN P-00-1108 

A-003 Initial Review Exposure Report for 

PMN P-00-1108 

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A-001 

Structure Activity Team (SAT) Report

for PMN P-00-1108 

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STRUCTURE ACTIVITY TEAM REPORT 08/22/00

CASE NUMBER: P00-1108

RELATED CASES: 

CONCLUSIONS/DISCUSSIONS

TYPE OF CONCERN: HEALTH ECOTOX

LEVEL OF CONCERN: 1-2 3

KEYWORDS: LIVER THYROID

MUTA DEVEL

SENS-L,S

AQUATOX

SUMMARY OF ASSESSMENT

FATE: Liquid

LogKow = 2.47(M); S (mg/L, 25EC) = 0.238(M); H = 4.09E-3(E)

MP (C) < 20(E); BP (C) = 386( ) based on 217EC @ 4mm(M); 

VP @ 25C (mm) = 1.8E-6(M)

LogKoc = 4.20(E); LogBCF = 1.20(E); 

POTW removal (%) = 90 via biodeg; 

Time for complete ultimate aerobic biodeg = wk

PBT Potential: P1B1T1

Hydrolysis Halflife $ mo for epoxide

Sorption to soils/sediments = moderate - strong

*CEB FATE: Migration to ground water = slow - moderate

Volatilization Halflife Rivers = 12 da; Lake (da) = 140

Atmospheric Oxidation (halflife, hrs) OH = 4.7

HEALTH: Expect poor absorption via all routes (pchem); expect

some ester hydrolysis. Concern for liver and thyroid toxicity

based on submitted test data; mutagenicity based on test data for

an analogue ( positive for chromosome aberrations in bone

marrow of rats at 2100 mg/kg but not 1050 mg/kg); respiratory and

dermal sensitization from the epoxide; and developmental toxicity

based on the 2-ethylhexanol hydrolysis product and the effects on

the thyroid.

*CEB HEALTH: Low moderate concern (Dermal, inhalation)

Test data: (-) Salmonella with and without activation; (-)

E. coli with and without activation; (-) for chromosome aberrations in human lymphocytes; rat oral LD50 >1000 mg/kg, 1 death at

1000 mg/kg, liver and thyroid effects

ECOTOX: Predicted (P) and measured (M) toxicity values in mg/L

(ppm) are:

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fish 96-h LC50 = * P

fish (RT) 96-h LC50 = * M SR,N

daphnid 48-h LC50 = * P

daphnid 48-h LC50 = * M S,N

green algal 96-h EC50 = 0.030 or * P

green algal 72-h EC50 = * M S,N

fish chronic value = 0.008 P

daphnid ChV = 0.005 P

algal ChV = 0.030 or * P

algal ChV = * M S,N

Predictions are based on SARs for epoxides; SAR chemical class =

; MW411; log Kow = 6.2 (ClogP), 7.3 (SRC),

2.47 (M); pH7; effective concentrations based on 100% active

ingredients and mean measured concentrations; hardness <180.0

mg/L as CaCO3; and TOC <2.0 mg/L;

high concern;

assessment factor = 10.0

concern concentration = 0.001

*CEB ECOTOX: All releases to water

SAT Co-chair: Leonard Keifer 260-1548

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A-002 

Initial Review Engineering Report

for PMN P-00-1108 

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A-003 

Initial Review Exposure Report

for PMN P-00-1108 

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