Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

PC Code: 006329

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND

 POLLUTION PREVENTION

MEMORANDUM

Date: 25-AUG-2010 

SUBJECT: Acequinocyl. Chronic Aggregate Dietary (Food and Drinking Water) Exposure 

and Risk Assessment for the Section 3 Registration Action Use on Fruiting 

Vegetables, Hops, Okra, and Edible-Podded Beans.

PC Code: 006329 DP Barcode: D369101

Decision No.: 417967 Registration No.: 66330-38

Petition No.: 9E7598 Regulatory Action: Section 3

Risk Assessment Type: Dietary Case No.: 7621

TXR No.: NA CAS No.: 57960-19-7

MRID No.: NA 40 CFR: §180.599

FROM: Sarah J. Levy, Chemist

Risk Assessment Branch 1 (RAB1)/Health Effects Division (HED; 7509P)

THROUGH: Nancy Dodd, Chemist

David Soderberg, Chemist

Dietary Exposure Science Advisory Council (DESAC)/HED (7509P)

and

George F. Kramer, Ph.D., Branch Senior Scientist

Branch/Health Effects Division (7509P)

TO: Sarah J. Levy, Chemist/Risk Assessor

RAB1/HED (7509P)

and

Barbara Madden, RM 05

Registration Division (RD; 7505P)
Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Executive Summary

A chronic aggregate dietary (food and drinking water) exposure and risk assessment was

conducted using the Dietary Exposure Evaluation Model (DEEM-FCIDTM, Version 2.03) which 

use food consumption data from the U.S. Department of Agriculture’s Continuing Surveys of 

Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. The analysis was performed to 

support a requested Section 3 registration use of the insecticide acequinocyl (2-(acetyloxy)-3-

dodecyl-1,4-naphthalenedione) on fruiting vegetables, hops, okra, and edible-podded beans. An 

acute dietary assessment was not conducted for acequinocyl because an endpoint of concern 

attributable to a single dose was not identified; therefore, an aRfD was not established. A cancer 

dietary assessment was not conducted because acequinocyl was classified as not likely to be 

carcinogenic to humans.

 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

Tolerance-level residues and 100 percent crop treated (%CT) data were used in the chronic 

dietary assessment. DEEMver. 7.81 default processing factors were used with the exception of 

grape juice and raisins (see “Residue Information” Section of this document for details). For the 

chronic dietary assessment, the general U.S. population and all population subgroups have risk 

estimates which are not of concern to HED. The chronic dietary exposure estimate for the U.S. 

population is 9.8% of the chronic population-adjusted dose (cPAD). The highest exposed 

population subgroup (children 1-2 years old) occupies 45% of the cPAD. The use of anticipated 

residues (ARs), empirical processing factors, and %CT would refine further HED’s exposure and 

risk estimates; however, refinement is not needed at this time.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to point 

of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References which discuss the acute and chronic risk assessments in more detail 

are available on the EPA/pesticides web site: “Available Information on Assessing Exposure 

from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for acequinocyl was conducted by Sarah Levy (11-DEC2007; DP# 347404).
Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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II. Residue Information

Under PP#9E7598, the Interregional Research Project No.4 (IR-4), on behalf of the Agricultural 

Experiment Stations of AZ, CA, CO, FL, ID, NC, NJ, NY, OK, OR, TN, TX, VA, and WA, has 

submitted a petition proposing the use of acequinocyl (Kanemite15 soluble concentrate (SC), 

1.25 lb/gal), a quinoline type of miticide, on fruiting vegetables, hops, okra, and edible-podded 

beans. Permanent tolerances are currently established under 40 CFR §180.599(a) for the 

combined residues of acequinocyl and its metabolite, 2-dodecyl-3-hydroxy-1,4-naphthoquinone, 

expressed as acequinocyl equivalents, in/on a number of plant and livestock commodities. 

Tolerances for plant commodities range from 0.02 ppm (tree nuts and pistachios) to 30 ppm 

(citrus oil), and tolerances for livestock commodities are established at 0.02 ppm in the fat and 

liver of cattle, goat, horse, and sheep. There are residential uses (greenhouse, ornamental, etc.) 

for acequinocyl established as well. Note that for this petition, there are no livestock feedstuffs 

associated with the proposed crop uses; therefore, re-evaluation of the registered livestock 

tolerance levels is not necessary at this time.

Based on the structural similarity of acequinocyl-OH to parent and the presence of acequinocylOH at quantifiable levels in crops, the HED Metabolism Assessment Review Committee 

(MARC) concluded that parent and acequinocyl-OH are the residues of concern for risk 

assessment and tolerance expression in apples, oranges, and eggplant commodities (Memo, S. 

Levy, 07-JAN-2004; DP# 297872). For purposes of this petition, HED is willing to translate 

these results to hops and edible-podded beans as these two crops are low-consumption food 

items. See Table 1 for a summary of the residues of concern determined by the MARC.

Table 1. Residues of Concern in Crops, Ruminants, and Drinking Water.

Matrix Tolerance Expression Residues for Risk Assessment

Fruit Crops Acequinocyl + Acequinocyl-OH (R1) Acequinocyl + Acequinocyl-OH (R1)

Ruminants Acequinocyl + Acequinocyl-OH (R1) Acequinocyl + Acequinocyl-OH (R1). In 

liver and kidney, also include AKM-15.

Rotational Crops Not Determined* Not Determined*

Drinking Water NA** Acequinocyl + Acequinocyl-OH (R1)

* A confined rotational crop study has been reviewed and a 30-day plant-back interval has been recommended 

(DP#351336, S. Levy, 6/25/08).

** NA = not applicable.

Residue Data used for the Chronic Assessment:

Tolerance-level residues and 100%CT data were used in the chronic dietary assessment. 

DEEMver. 7.81 default processing factors were used with the exception of grape juice and 

raisins. As residues were reduced in both grape juice (<0.02x) and raisin (0.15x), separate 

tolerances are not required for these commodities; therefore, the DEEM ver. 7.81 default 

processing factors for juice and raisin were set to 1 as concentration was shown not to occur

(Memo, S. Levy, 05-SEP-2007; DP#: 342805). The tolerance value of 0.02 ppm for cattle, goat, 

horse, and sheep fat and liver was entered for meat byproducts as well, where applicable.
Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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The use of ARs, empirical processing factors, and %CT data would refine further HED’s 

exposure and risk estimates. However, refinement of the dietary exposure estimates is not 

needed at this time. See Table 2 for a summary of the data used in the chronic assessment.

Table 2. Data and Residue Estimates Used in the Acequinocyl Chronic Dietary Analyses.

Commodity Data Source

(MRID) %CT Processing Factors HED-Recommended Tolerance (ppm)

Vegetable, fruiting, group 8 47819401,

47819402

100

NA 0.70

Okra1 Translated NA 0.70

Bean, edible podded 47819403 NA 0.25

Hop, dried cones 47819404 NA 4.0

1

 Okra has been recommended to be added as a member of the fruiting vegetable group 8; however, until okra has 

been officially added to the crop group, a separate tolerance is required for okra at the same tolerance level (0.70 

ppm) as for fruiting vegetables.

III. Drinking Water Data

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) (I. Maher, 29-APR-2010; DP# 368426) and 

incorporated directly into this dietary assessment. Water residues were incorporated directly into 

DEEM-FCID under the food categories “water, direct, all sources” and “water, indirect, all 

sources.”

Acequinocyl can reach surface water via spray drift and less likely via runoff. Due to its high Kd

values it is expected to exhibit low mobility in soil and low potential to leach into groundwater.

Once acequinocyl has entered surface water, it is not likely to persist as it will hydrolyze to form 

hydroxy-acequinocyl (also known as OH-AKD 023, 2-hydroxy-3-dodecyl-1,4-napthelenedione 

(HDNQ), and R-1).

There are no drinking water monitoring data available for acequinocyl or its metabolite

acequinocyl-OH (R1), the residues of concern. Groundwater and surface water estimated 

drinking water concentrations (EDWCs) were generated for acequinocyl using the Screening 

Concentration in Ground Water (SCI-GROW) and Pesticide Root Zone Model/Exposure 

Analysis Modeling System (PRZM/EXAMS) models, respectively. Two approaches were used 

in performing the drinking water assessment for the proposed acequinocyl uses. In Approach #1, 

acequinocyl was conservatively assumed to be stable to all routes of degradation to account for 

the uncertainties associated with the environmental fate data. In Approach #2, total (acequinocyl 

+ acequinocyl-OH) residues were modeled with the assumption that the metabolite acequinocylOH (referred to as the R1 degradate in this assessment) is of toxicological concern. The highest 

PRZM-EXAMS surface water modeling estimates were obtained for the Pennsylvania tomato 

scenario for the chronic values. The modeled EDWCs for ground and surface water are 

summarized in Table 3.
Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Table 3. Ground and Surface Water EDWCs for Acequinocyl.

Approach #1 and #2

Groundwater EDWC for 

Acequinocyl + R1 (ppb)

Surface Water

Approach #1

Acequinocyl

Approach #2

Acequinocyl + R1

1-in-10-Year Chronic Mean

Concentration (ppb)

1-in-10-Year Chronic Mean

Concentration (ppb)

0.0036 2.45 0.29

Since the surface water EDWCs are higher than the groundwater EDWC, HED selected the 

surface water value for use in the chronic dietary assessment. The EDWC derived via Approach

#1 represents the upper-bound value (2.45 ppb) while that derived via Approach #2 represents 

the lower-bound value (0.29). The 2.45 ppb value was used in the dietary modeling as this value 

assures a conservative assessment.

IV. DEEM-FCIDTM Program and Consumption Information

An acequinocyl chronic dietary exposure assessment was conducted using DEEM-FCIDTM,

Version 2.03 which incorporates consumption data from USDA’s CSFII, 1994-1996 and 1998. 

The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals 

over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to 

EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; or wheat 

flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed 

jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are 

averaged for the entire U.S. population and within population subgroups, but for acute exposure 

assessment are retained as individual consumption events. Based on analysis of the 1994-96, 98 

CSFII consumption data, which took into account dietary patterns and survey respondents, HED 

concluded that it is most appropriate to report risk for the following population subgroups: the 

general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 

13-19, adults 20-49, females 13-49, and adults 50+ years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

V. Toxicological Information

On 14-OCT-2003, the HED Hazard Identification Assessment Review Committee (HIARC) 

reviewed the recommendations of the toxicology reviewer for acequinocyl with regard to the 

acute and chronic RfDs and the toxicological endpoint selection for use as appropriate in 

occupational/residential exposure risk assessments. The potential for increased susceptibility of 

infants and children from exposure to acequinocyl was also evaluated as required by the Food 

Quality Protection Act (FQPA) of 1996 under the 2002 OPP 10X Guidance. Table 4 is a 
Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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summary of the toxicology doses and endpoints selected that are relevant to dietary exposure 

assessment (TXR# 0052234, 13-NOV-2003). The acequinocyl risk assessment team confirmed 

that the endpoints selected previously remain appropriate.

Table 4. Summary of Toxicological Doses and Endpoints for Acequinocyl for Use in Dietary Exposure Risk 

Assessment.1

Exposure/

Scenario

Point of 

Departure

Uncertainty/

FQPA Safety 

Factors

RfD, PAD, Level of 

Concern 

Study and Toxicological Effects

Acute Dietary 

(General 

Population, 

including 

Infants and 

Children)

N/A N/A N/A

An endpoint of concern (effect) 

attributable to a single dose was 

not identified in the database. 

Quantification of acute risk to 

general population including 

infants and children is not 

required.

Chronic 

Dietary (All 

Populations)

NOAEL= 

2.7 

mg/kg/day

UFA= 10x

UFH=10x

FQPA SF= 1x

cPAD = cRfD = 

0.027 mg/kg/day 

18-month carcinogenicity study in 

mice;

LOAEL=7.0 mg/kg/day based on 

clinical chemistry and microscopic 

nonneoplastic lesions (brown 

pigmented cells and perivascular 

inflammatory cells in liver)

1

 UF = uncertainty factor, UFA = extrapolation from animal to human (interspecies), UFH = potential variation in 

sensitivity among members of the human population (intraspecies), FQPA SF = FQPA Safety Factor, NOAEL = no 

observed adverse effect level, LOAEL = lowest observed adverse effect level, RfD = reference dose (a = acute, c = 

chronic), PAD = population adjusted dose, MOE = margin of exposure, LOC = level of concern, N/A = Not 

Applicable, UFDB = database uncertainty factor, UFL = uncertainty factor for lack of a NOAEL. 

VI. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in Table 5 are for the general 

U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50+ years. An acute dietary assessment was not 

conducted for acequinocyl because an endpoint of concern attributable to a single dose was not 

identified; therefore, an aRfD was not established. A cancer dietary assessment was not 

conducted because acequinocyl was classified as not likely to be carcinogenic to humans.

The chronic dietary exposure assessment (using tolerance level residues and 100% CT 

information for all registered and proposed uses) was conducted for the general U.S. population 

and various population subgroups. Drinking water was incorporated directly into the dietary

assessment using the chronic concentration for ground water generated by the PRZM/EXAMS

model. This assessment concludes that the chronic dietary exposure estimates are not of concern 

to HED for the general U.S. population (9.8% cPAD) and all population subgroups. The most 

highly exposed population subgroup is children 1-2 years old at 45% of the cPAD. The use of 

ARs, empirical processing factors, and %CT data would refine further HED’s exposure and risk 

estimates; however, refinement is not needed at this time.
Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Table 5. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Acequinocyl.

Population Subgroup

Chronic Dietary1

Dietary Exposure

(mg/kg/day)

% cPAD

U.S. Population (total) 0.002657 9.8

All Infants (< 1 year old) 0.005584 21

Children 1-2 years old 0.012193 45

Children 3-5 years old 0.008046 30

Children 6-12 years old 0.003657 14

Youth 13-19 years old 0.001855 6.9

Adults 20-49 years old 0.001758 6.5

Adults 50+ years old 0.001811 6.7

Females 13-49 years old 0.001808 6.7

1 Chronic dietary endpoint of 0.027 mg/kg/day applies to the general U.S. population and all population subgroups. The values 

for the highest exposed population for each type of risk assessment should be bolded.

VII. Conclusions

A chronic dietary exposure and risk assessment was conducted for the proposed food uses and 

permanent tolerances of acequinocyl, including potential exposure from drinking water. 

The chronic dietary (food + drinking water) exposure to acequinocyl is below HED’s level of 

concern for the general U.S. population and all population subgroups. The chronic dietary

exposure utilized 9.8% cPAD for the general U.S. population and 45% of the cPAD for children 

1-2 years old, the most highly exposed population subgroup. An acute dietary assessment was 

not conducted for acequinocyl because an endpoint of concern attributable to a single dose was 

not identified; therefore, an aRfD was not established. A cancer dietary assessment was not 

conducted because acequinocyl was classified as not likely to be carcinogenic to humans.

VIII. List of Attachments

Attachment 1: Chronic Food plus Drinking Water Residue Input File.

Attachment 2: Chronic Results File.

cc: I. Maher (EFED/ERBI; 7507P)

RDI: DESAC (19-MAY-2010); G.F. Kramer (24-MAY-2010)

S. Levy:S10953:PY1:(703)305-0783:7590P
Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Attachment 1: Chronic Food plus Drinking Water Residue Input File.

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for ACEQUINOCYL 1994-98 data

Residue file: C:\Documents and Settings\slevy\Desktop\Acequinocyl\006329c.R98

 Adjust. #2 used

Analysis Date 05-26-2010 Residue file dated: 05-26-2010/09:02:01/8

Reference dose (RfD) = 0.027 mg/kg bw/day

Comment:No acute dietary endpoint; not carcinogen. cRfD=cPAD

-----------------------------------------------------------------------------

Food Crop Residue Adj.Factors 

Comment

EPA Code Grp Food Name (ppm) 

 #1 #2

-------- ---- ---------------------- ---------- ------ ------ -------

14000030 14 Almond 0.020000 1.000 1.000 

14000031 14 Almond-babyfood 0.020000 1.000 1.000 

14000040 14 Almond, oil 0.020000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.020000 1.000 1.000 

11000070 11 Apple, fruit with peel 0.400000 1.000 1.000 

11000080 11 Apple, peeled fruit 0.400000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 0.400000 1.000 1.000 

11000090 11 Apple, dried 0.400000 8.000 1.000 

11000091 11 Apple, dried-babyfood 0.400000 8.000 1.000 

11000100 11 Apple, juice 0.400000 1.300 1.000 

11000101 11 Apple, juice-babyfood 0.400000 1.300 1.000 

11000110 11 Apple, sauce 0.400000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 0.400000 1.000 1.000 

06010430 6A Bean, snap, succulent 0.250000 1.000 1.000 

9E7598

06010431 6A Bean, snap, succulent-babyfood 0.250000 1.000 1.000 

9E7598

21000460 M Beef, meat byproducts 0.020000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.020000 1.000 1.000 

21000470 M Beef, fat 0.020000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.020000 1.000 1.000 

21000490 M Beef, liver 0.020000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.020000 1.000 1.000 

14000590 14 Brazil nut 0.020000 1.000 1.000 

14000680 14 Butternut 0.020000 1.000 1.000 

14000810 14 Cashew 0.020000 1.000 1.000 

14000920 14 Chestnut 0.020000 1.000 1.000 

10001060 10 Citrus citron 0.200000 1.000 1.000 

10001070 10 Citrus hybrids 0.200000 1.000 1.000 

10001080 10 Citrus, oil 30.000000 1.000 1.000 

11001290 11 Crabapple 0.400000 1.000 1.000 

08001480 8 Eggplant 0.700000 1.000 1.000 

9E7598

14001550 14 Filbert 0.020000 1.000 1.000 

14001560 14 Filbert, oil 0.020000 1.000 1.000 

23001710 M Goat, fat 0.020000 1.000 1.000 

95001750 O Grape 1.600000 1.000 1.000 

95001760 O Grape, juice 1.600000 1.000 1.000 

95001761 O Grape, juice-babyfood 1.600000 1.000 1.000 

95001770 O Grape, leaves 1.600000 1.000 1.000 

95001780 O Grape, raisin 1.600000 1.000 1.000 
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95001790 O Grape, wine and sherry 1.600000 1.000 1.000 

10001800 10 Grapefruit 0.200000 1.000 1.000 

10001810 10 Grapefruit, juice 0.200000 2.100 1.000 

14001850 14 Hickory nut 0.020000 1.000 1.000 

95001880 O Hop 4.000000 1.000 1.000 

9E7598

10001970 10 Kumquat 0.200000 1.000 1.000 

10001990 10 Lemon 0.200000 1.000 1.000 

10002000 10 Lemon, juice 0.200000 2.000 1.000 

10002001 10 Lemon, juice-babyfood 0.200000 2.000 1.000 

10002010 10 Lemon, peel 0.200000 1.000 1.000 

10002060 10 Lime 0.200000 1.000 1.000 

10002070 10 Lime, juice 0.200000 2.000 1.000 

10002071 10 Lime, juice-babyfood 0.200000 2.000 1.000 

11002100 11 Loquat 0.400000 1.000 1.000 

14002130 14 Macadamia nut 0.020000 1.000 1.000 

08002340 8 Okra 0.700000 1.000 1.000 

9E7598

10002400 10 Orange 0.200000 1.000 1.000 

10002410 10 Orange, juice 0.200000 1.800 1.000 

10002411 10 Orange, juice-babyfood 0.200000 1.800 1.000 

10002420 10 Orange, peel 0.200000 1.000 1.000 

11002660 11 Pear 0.400000 1.000 1.000 

11002661 11 Pear-babyfood 0.400000 1.000 1.000 

11002670 11 Pear, dried 0.400000 6.250 1.000 

11002680 11 Pear, juice 0.400000 1.000 1.000 

11002681 11 Pear, juice-babyfood 0.400000 1.000 1.000 

14002690 14 Pecan 0.020000 1.000 1.000 

08002700 8 Pepper, bell 0.700000 1.000 1.000 

9E7598

08002701 8 Pepper, bell-babyfood 0.700000 1.000 1.000 

9E7598

08002710 8 Pepper, bell, dried 0.700000 1.000 1.000 

9E7598

08002711 8 Pepper, bell, dried-babyfood 0.700000 1.000 1.000 

9E7598

08002720 8 Pepper, nonbell 0.700000 1.000 1.000 

9E7598

08002721 8 Pepper, nonbell-babyfood 0.700000 1.000 1.000 

9E7598

08002730 8 Pepper, nonbell, dried 0.700000 1.000 1.000 

9E7598

14002820 14 Pistachio 0.020000 1.000 1.000 

10003070 10 Pummelo 0.200000 1.000 1.000 

11003100 11 Quince 0.400000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.020000 1.000 1.000 

26003410 M Sheep, fat 0.020000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.020000 1.000 1.000 

95003590 O Strawberry 0.400000 1.000 1.000 

95003591 O Strawberry-babyfood 0.400000 1.000 1.000 

95003600 O Strawberry, juice 0.400000 1.000 1.000 

95003601 O Strawberry, juice-babyfood 0.400000 1.000 1.000 

10003690 10 Tangerine 0.200000 1.000 1.000 

10003700 10 Tangerine, juice 0.200000 2.300 1.000 

08003740 8 Tomatillo 0.700000 1.000 1.000 

9E7598
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08003750 8 Tomato 0.700000 1.000 1.000 

9E7598

08003751 8 Tomato-babyfood 0.700000 1.000 1.000 

9E7598

08003760 8 Tomato, paste 0.700000 1.000 1.000 

9E7598

08003761 8 Tomato, paste-babyfood 0.700000 1.000 1.000 

9E7598

08003770 8 Tomato, puree 0.700000 1.000 1.000 

9E7598

08003771 8 Tomato, puree-babyfood 0.700000 1.000 1.000 

9E7598

08003780 8 Tomato, dried 0.700000 1.000 1.000 

9E7598

08003781 8 Tomato, dried-babyfood 0.700000 1.000 1.000 

9E7598

08003790 8 Tomato, juice 0.700000 1.000 1.000 

9E7598

14003910 14 Walnut 0.020000 1.000 1.000 

86010000 O Water, direct, all sources 0.002450 1.000 1.000 

86020000 O Water, indirect, all sources 0.002450 1.000 1.000 
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Attachment 2: Chronic Results File.

U.S. Environmental Protection Agency Ver. 2.00

DEEM-FCID Chronic analysis for ACEQUINOCYL (1994-98 data)

Residue file name: C:\Documents and 

Settings\slevy\Desktop\Acequinocyl\006329c.R98

 Adjustment factor #2 used.

Analysis Date 05-26-2010/09:02:22 Residue file dated: 05-26-2010/09:02:01/8

Reference dose (RfD, Chronic) = .027 mg/kg bw/day

COMMENT 1: No acute dietary endpoint; not carcinogen. cRfD=cPAD

=============================================================================

 Total exposure by population subgroup

-----------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------

U.S. Population (total) 0.002657 9.8%

U.S. Population (spring season) 0.002596 9.6%

U.S. Population (summer season) 0.002685 9.9%

U.S. Population (autumn season) 0.002656 9.8%

U.S. Population (winter season) 0.002692 10.0%

Northeast region 0.003098 11.5%

Midwest region 0.002605 9.6%

Southern region 0.002340 8.7%

Western region 0.002822 10.5%

Hispanics 0.002932 10.9%

Non-hispanic whites 0.002630 9.7%

Non-hispanic blacks 0.002535 9.4%

Non-hisp/non-white/non-black 0.002797 10.4%

All infants (< 1 year) 0.005584 20.7%

Nursing infants 0.002797 10.4%

Non-nursing infants 0.006642 24.6%

Children 1-6 yrs 0.008946 33.1%

Children 7-12 yrs 0.003387 12.5%

Females 13-19 (not preg or nursing) 0.001912 7.1%

Females 20+ (not preg or nursing) 0.001808 6.7%

Females 13-50 yrs 0.001991 7.4%

Females 13+ (preg/not nursing) 0.001997 7.4%

Females 13+ (nursing) 0.002049 7.6%

Males 13-19 yrs 0.001787 6.6%

Males 20+ yrs 0.001738 6.4%

Seniors 55+ 0.001830 6.8%

Children 1-2 yrs 0.012193 45.2%

Children 3-5 yrs 0.008046 29.8%

Children 6-12 yrs 0.003657 13.5%

Youth 13-19 yrs 0.001855 6.9%

Adults 20-49 yrs 0.001758 6.5%

Adults 50+ yrs 0.001811 6.7%

Females 13-49 yrs 0.001808 6.7%

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