EPA Registration Number 

66330-333 

Vol. 3 

1
, 

- 1111111111111111111111111111 

2
Please Return Jacket to File Room for Data Extraction 

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Cc: montague.kathryn, 

SUBJECT: Please Return Jacket to File Room for Data Extraction for Registration: Decision: 393160 

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Then give the material with this coversheet to staff in the 

Information Services Center (Room S-4900). 

Reviewer's N a me;..: """';':fI,~~1A o!!>,o!..Jo.-4M. Xl.I~~-

Phone: ]0334103&1 Division: R.O/HB 

Date: -----1-1 '7 / -'-O-'-1/!-""o""-A-'--______ _ 1/ 

Created August 19, 2008 

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U.S. ENVIRONMENTAL PROTECTION - EPA Reg. Number: Date of Issuance: 

",,"'<teO ~1T"r. AGENCY v '. 66330-333 f ~ ~ Office of Pesticide Programs 

.. 

,~. , Registration Division (7505P) ".., ~ 'l . '--" --

Ariel Rios Building ,_, _ 'J "( "ROlf.' 

1200 Pennsylvania Ave., NW 

Washington, D.C. 20460 

NOTICE OF PESTICIDE: Term of Issuance: 

_ Registration 

-.X. Reregistration Name of Pesticide Product: 

(under FIFRA, as amended) Thidiazuron-Diuron EC 

Name and Address of Registrant (include ZIP Code): 

Arysta LifeScience North America, LLC 

15401 Weston Parkway, Suite 150 

Cary, NC 27513 

Note: Changes in labeling differing in substance from that accepted in connection with this 

registration must be submitted to and accepted by the Registration Division prior to use of the label 

in commerce. In any correspondence on this product always refer to the above EPA registration 

number. 

On the basis of infonnation furnished by the registrant, the above named pesticide is hereby 

registered/reregistered under the Federal Insecticide, Fungicide and Rodenticide Act. Registration is 

in no way to be construed as an endorsement or recommendation of this product by the Agency. In 

order to protect health and the environment, the Administrator, on his motion, may at any time 

suspend or cancel the registration of a pesticide in accordance with the Act. The acceptance of any 

name in connection with the registration of a product under this Act is not to be construed as giving 

the registrant a right to exclusive use of the name or to its use if it has been covered by others. 

This product is reregistered in accordance with FIFRA provided that you: 

I) Submit and/or cite all data required for registration/reregistration review of your 

product when the Agency requires all registrants of similar products to submit data. 

Signature of Approving Official: Date: 

/5/ 0[-("> , i: 

;< ',-, c, 

Joanne Miller 

Senior Registration Specialist 

Herbicide Branch, Team 23 

Registration Division (7505P) 

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Page 2 

EPA Reg. 66330-333 

2. Delete "Thidiazuron products ... exposures due to drift would be reduced" from the 

Agricultural Use Requirements box on page 5. Place the following language in the Spray Drift 

section, "Thidiazuron products can not be applied by air within 'li mile of lettuce or within 5 

miles upwind of citrus in flush (burst of new growth, as in springtime) in the Rio Grande Valley 

of Texas. Ground applications are restricted to no less than 100 feet away from lettuce and no 

less than 'li mile upwind from citrus. (In general, a decrease in droplet size ... would be 

reduced)." 

3. On page 6, add "except as noted for lettuce and citrus" after "Do not apply by air if sensitive 

non-target crops are within 100 feed of the application site." 

4. Change the PPE section to: 

"Some materials that are chemical-resistant to this product are made of barrier laminate or butyl 

rubber. If you want more options, follow the instructions for category B on an EPA chemicalresistance category selection chart. 

Pilots and flaggers must wear: Long-sleeved shirt and long pants, shoes, and socks. 

Mixers, loaders, applicators, and other handlers must wear: Coveralls over short-sleeved shirt 

and short pants, chemical-resistant shoes plus socks, goggles or faceshield, chemical-resistant 

gloves, chemical-resistant headgear for overhead exposure, chemical-resistant apron when 

mixing, loading, or cleaning equipment or spills, and NIOSH approved particulate filtering 

respirator equipped with N, R, or P class filter media. The respirator should have a NIOSH 

approval number prefix TC-84A. It is recommended that you require that the respirator wearer 

be fit tested, and trained in the use, maintenance, and limitations of the respirator. See 

engineering controls for additional requirements." 

5. Additional text in bold must be added "Maximum application rate ofO.3Ibs. ai thidiazuron 

per acre per year. Maximum of2 applications, but not to exceed 0.3 lbs. ai thidiazuron per acre 

per year." Also add "Maximum Thidiazuron application rate is 0.125 lbs. ai/A (under normal 

conditions) or 0.2Ibs. ai/A (under variable conditions)." 

6. On page 3, delete "General" from "General Infonnation". 

7. On page 6, change "the spray boom should" to "the spray boom must". 

8. On page 6 and throughout the label, change "recommended" to "directed" and 

"recommendations" to "directions". 

9. On page 8, add "to the extent consistent with applicable law" in front of "Arysta LifeScience 

North America, LLC assumes no liability" and "all such risks shall be assumed". 

10. On page 7, clarifY the heading "active ingredients per acre" and revise the amounts, the 

numbers in ais per acre correspond only to the amounts of diuron. 

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Page 3 

EPA Reg. 66330-333 

A stamped copy of the label is enclosed for your records. You must submit one copy of the final 

printed label before you release the product for shipment. Products shipped after 12 months from 

the date of this letter or the next printing of the label whichever oeems first, must bear the new 

revised label. If these conditions are not complied with, the registration will be subject to 

cancellation in accordance with FIFRA. Yom release for shipment of the product constitutes 

acceptance of these conditions. This label supersedes all other previously accepted labels. If you 

have any questions please call Erik Kraft at 703~308~9358 or email atKraft.Erik@epa.gov. 

7
THIDIAZURON-DIURON EC 

COTTON DEFOLIANT 

For Agricultural Use Only 

RED + PR Notice 2007~4 

ACCEPTED 

with COMMENTS 

In EPA Lettel' Dated: 

ACTIVE INGREDIENTS: Thidiazuron: N~phenyl~N'~1 ,2,3~thidiazol-5~ylurea* 1 " c! Inseclicidc. . ... ............ giddc, and Rodenticide Act 

Diuron: 3~(3,4~dichlorophenyl)~ 1, 1~dimethylurea* .... ......... ...... ... ............. amended, forthe pesticide 

OTHER INGREDIENTS:.... . ................ . ................................ ~tcred under EPA Reg. No. 

TOTAL 100% 

Contains 1 lb. Thidiazuron per gallon and 0.5 lb. Diuron per gallon Gio330-S33 

KEEP OUT OF REACH OF CHILDREN 

DANGER - PELIGRO 

Si usted no entiende la etiqueta, busque a alguien para que se la explique a usted en detalle. 

(If you do not understand this label, find someone to explain it to you in detail.) 

IF IN EYES: 

IF ON SKIN OR 

CLOTHING: 

IF INHALED: 

IF SWALLOWED: 

• 

• 

• 

• 

• 

• 

• 

• 

• 

• 

• 

FIRST AID 

Hold eye open and rinse slowly and gently with water for 15~20 minutes. 

Remove contact lenses, if present, after the first 5 minutes, then continue 

rinsing. 

Call a poison control center or doctor for treatment advice. 

Take off contaminated clothing. 

Rinse skin immediately with plenty of water for 15~20 minutes. 

Call a Doison control center or doctor for treatment advice. 

Move person to fresh air. 

If person is not breathing, call 911 or an ambulance, then give artificial 

respiration, preferably mouth~to~mouth is possible. 

Call a poison control center or doctor for treatment advice. 

Immediately call a poison control center or doctor for treatment advice. 

Do not induce vomiting unless told to do so by a poison control center or 

doctor. 

• Have person sip a glass or water if able to swallow. , , 

• Do not (live anvthinq by mouth to an unconscious persor<.' , " , : ' •••• 

NOTE TO PHYSICIAN: If in eyes, refer to an ophthalmologist for follow~up carer-;-·:'--:'--;-.--1 

Probable mucosal damage may contraindicate the use of gastric lavage. , , ;...:...:..~. __ -'-'~::...' --I 

HOT LINE NUMBER ' , 

" EMERGENCY TELEPHONE NUMBERS: , , , " 

, , . , " " , Have the product container or label with you when calling a poison control center or doctbr C'r going for 

treatment. "'" "" 

FOR 24·HOUR EMERGENCY MEDICAL ASSISTANCE CALL: 1.866·303·6962 ' ",,' 

FOR CHEMICAL EMERGENCY: Spill, leak, fire, exposure, or accident call CHEMTREC 1~800~424~9290 " , , 

SEE INSIDE (SIDE PANEL) FOR ADDITIONAL PRECAUTIONS AND USE DIRECTIONS 

EPA Reg. No, 66330~333 

AD 081508 

EPA Est. No. 51036~GA~001 

NET CONTENTS: ___ _ 

Manufactured for 

Arysta LifeScience North America, LLC 

15401 Weston Parkway, Suite 150 

Cary, NC 27513 

Filename: Thidiazuron-Diuron EC (333-RED 020507) AD08t508 RED + PR 2007-4 (C!can).doc 

Page I 

8
PRECAUTIONARY STATEMENTS 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

DANGER 

RED + PR Notice 2007-4 

Corrosive. Causes irreversible eye damage. Causes skin irritation. Do not get in eyes, on skin, or on 

clothing. 

PERSONAL PROTECTIVE EQUIPMENT (PPE) 

All mixers, loaders, and applicators must wear: 

• Long-sleeved shirt 

• Long pants 

• Shoes and socks 

• Chemical-resistant gloves 

• Goggles, face shield, or glasses 

• Chemical-resistant apron when mixing, loading or cleaning equipment or spills, and chemicalresistant headgear for overhead exposure 

See Engineering Controls for Requirements 

In addition to the PPE above, all handlers except for ground boom applicators, pilots, and flaggers must 

also wear a NIOSH approved particulate filtering respirator equipped with N,R, or P class filter media. 

The respirator should have a NIOSH approval number prefix TC-84A. It is recommended that you require 

that the respirator wearer be fit tested, and trained in the use, maintenance, and limitations of the 

respirator. 

USERS SAFETY REQUIREMENTS 

Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables 

exist, use detergent and hot water. Keep and wash PPE separately from other laundry. 

ENGINEERING CONTROLS STATEMENT 

Engineering Controls for Aerial Application: Enclosed Cockpits 

Engineering Controls: Pilots must use an enclosed cockpit that meets the requirements, listed in the 

Worker Protection Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)]. 

Flaggers supporting aerial applications must use an enclosed cab that meets the definition in the Worker 

Protection Standard for Agricultural Pesticides [40 CFR 170.240(d)(5)] for dermal protection. In addition, 

flaggers must wear long-sleeved shirt, long pants, shoes, and socks. 

,----------"U"SEiCR""S"'AcF"ETYTVDR"E"C"O"M"'M"E"N"'D"A"'T'"IO"N'"S,-----,,-,-,--: .. ••• 

Users should: 

• Wash hands before eating, drinking, chewing gum, using tobacco, or using tne toilet. , 

• Remove cI?thing/PPE immediately if pesticide gets inside. Then wash thor6~ghly and put:on 

clean clothing. , , ': •• 

• Remove PPE immediately after handling this product. Wash the outsid~'I)·I' gloves tJE:!for~ 

removin . As soon as ossible, wash thorou hi and chan e into clean clotlJip' ._, ' , , .. , > , > 

ENVIRONMENTAL HAZARDS , , 

Do not apply directly to water, or to areas where surface water is present or to intertidal areas belo~ the 

mean high water mark. Do not contaminate water when disposing of equipment wash water or rinsate. 

This product may contaminate water through drift of spray in the wind. This product has a high potential 

for runoff for several months or more after application. Poorly draining soils and soils with shallow water 

tables are more prone to produce runoff that contains this product. A level, well-maintained vegetative 

buffer strip between areas to which this product is applied and surface water features such as ponds, 

streams, and springs will reduce the potential for contamination of water from runoff. Runoff of this 

product will be reduced by avoiding applications when rainfall is forecasted to occur within 48 hours. 

Sound erosion control practices will reduce this product's contribution to surface water contamination. 

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9
RED + PR Notice 2007-4 

This chemical has properties and characteristics associated with chemicals detected in ground water. 

Use of this chemical in areas where soils are permeable, particularly where the water table is shallow, 

may result in groundwater contamination. 

STORAGE AND DISPOSAL 

Do not contaminate water, food, or feed by storage or disposal. 

PESTICIDE STORAGE: Store this product in a cool, dry place in its original container only. Container 

should be closed when not in use. Do not expose the product to open flame excessive heat. Store in 

original container and keep closed. 

PESTICIDE DISPOSAL: Pesticide wastes are acutely hazardous. Improper disposal of excess 

pesticide, spray mixture, or rinsate is a violation of Federal law. If these wastes cannot be disposed of 

by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or 

the Hazardous Waste representative at the nearest EPA Regional Office for guidance. 

CONTAINER DISPOSAL: Nonrefillable container. Do not reuse or refill this container. Triple rinse 

container (or equivalent) promptly after emptying. Triple rinse as follows: Empty the remaining contents 

into application equipment or a mix tank and drain for 10 seconds after the flow begins to drip. Fill the 

container y,. full with water and recap. Shake for 10 seconds. Pour rinsate into application equipment or 

a mix tank or store rinsate for later use or disposal. Drain for 10 seconds after the flow begins to drip. 

Repeat this procedure two more times. Offer for recycling, if available, or puncture and dispose of in 

sanitarv landfill, or bv other orocedures aooroved by State and local authorities. 

PHYSICAL OR CHEMICAL HAZARDS 

Do nol use or store near heat or open flame. 

To Contain a Spill: Absorb liquid by covering it with cat litter, commercial clay, lime, sand, sawdust, or soda ash. 

Once absorbed, bUry the cleaning materials and cleanse the spill area with a detergent and water solution. 

GENERAL INFORMATION 

THIDIAZURON-DIURON EC is a harvest aid for cotton, used for leaf removal prior to harvest. 

THIDIAZURON-DIURON EC can be applied in most weather conditions, both warm and cool. 

USE PRECAUTIONS 

This product is not to be applied through any type of irrigation system. 

Effectiveness of THIDIAZURON-DIURON EC will be reduced if rainfall occurs within 12 hours post 

application. ~, ,. :. 

Foliage from treated plants or gin trash is not to be fed to livestock. ' , , , , , , 

Rotation to the following crops requires the minimum specified periods be\ow. 9fter the : last 

application ofTHIDIAZURON-DIURON EC: " 

small grains, sorghum) corn, or root crops (except carrots, onions) .......................... two (2) ,moAfhs 

legumes (including alfalfa) or leafy vegetable (except lettuce) .. '.' i '.hyo (2) mOQths 

cole crops, garlic, safflower, tomatoes, and watermelon ....................................... ... '.:.'.i. two (2) 1lJ991hs 

carrots ......................................................................................................... three (3) t1J90ttlS 

onions ............................................................................................................. four (4) mont.hs 

cantaloupe, honeydew melon/casaba melon, muskmelon, or peppers ........................... five (5) mOf']th's 

lettuce ...................... when soil has been deep-plowed (12-15 inches) ....................... two (2) months 

OR lettuce ............. when soil is only disced (4-6 inches) .............................. nine (9) months 

All other crops........... ............... . ....................................................... twelve (12) months 

Special Note for inter-cropped grains and legumes planted either as cover crops or planted into 

treated fields before the minimum two (2) month plant back time after the final THIDIAZURON-DIURON 

EC application: Any such crops are prohibited for use as feed or food and may be used only as cover 

crops. 

Do not use immature crops for food or feed. 

Filename: Thidiazuron-Diuron EC (333-RED 020507) AD081508 RED + PR 2007-4 (Clean).doc 

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RED + PR Notice 2007~4 

Prevent spray drift from contacting crops other than mature cotton, since this product may 

defoliate or injure other plant species. 

Mixtures with organophosphates can increase nontarget crop phytotoxicity. Exercise additional care 

when lettuce, citrus, cantaloupes or any other edible crops are adjacent to THIDIAZURON~DIURON EC 

treated cotlon fields. 

PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL ONTO NONTARGET CROPS 

Under windy weather conditions, applications of THIDIAZURON~DIURON EC may drift to non-target 

crops. 

The following procedures can help reduce the potential for drift: 

• If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground 

applications ofTHIDIAZURON~DIURON EC. 

• Nozzle pressure of 20-30 psi is recommended. 

• Do not apply this product during a temperature inversion because drift potential is high. In addition, 

do not apply this product if the development of a temperature inversion appears likely during the 

application period. 

RIO GRANDE VALLEY OF TEXAS PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL 

The following procedures can help reduce the potential for drift: 

• If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground 

applications of THIDIAZURON-DIURON EC. If wind speeds are less than ten (10) miles per hour, 

observe local recommendations from your State Extension Cotton Specialist. 

• Nozzle pressure of 20-30 psi is recommended. 

• Do not apply this product during a temperature inversion because drift potential is high. In addition, 

do not apply this product if the development of a temperature inversion appears likely during the 

application period. 

• Use the maximum nozzle orifice size that provides proper coverage and deposition of this product. 

• CITRUS AREAS: Do not apply this product by ground within 0.5 mile or by air within 5 miles 

downwind of citrus in flush. 

DIRECTIONS FOR USE 

It is a violation of Federal law to use this product in a manner inconsistent with its labeling. 

Do not apply this product in a way that will contact workers or other persons, either directly or through 

drift. Only protected handlers may be in the area during application. 

,,, 

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RED + PR Notice 2007-4 

AGRICULTURAL USE REQUIREMENTS 

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR 

Part 170. This Standard contains requirements for the protection of agricultural workers on farms, 

forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for 

training, decontamination, notification, and emergency assistance. It also contains specific instructions 

and exceptions pertaining to the statement on this label about personal protective equipment (PPE), and 

restricted~entry interval. The requirements in this box only apply to uses of this product that are covered 

by the Worker Protection Standard. 

Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 24 

hours. For minimum early entry PPE use the following: 

PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and 

that involves contact with anything that has been treated, such as soil or water, is: 

• Coveralls 

• Chemical-resistant gloves made of any waterproof material 

• Shoes plus socks 

Thidiazuron products can not be applied by air within X. mile of lettuce or 5 mlles downwind of the pOint of 

application when citrus is in flush (burst of new growth, as in springtime) in the Rio Grande valley of 

Texas. Ground applications are restricted to 100 feet away from lettuce and X. mile downwind from the 

point of application for citrus. 

(In general, a decrease in droplet size or increase in wind speed at the time of application will result in 

risk to non-target organisms. Alternatively, if droplet size is coarser or wind speeds are lower, exposures 

due to drift would be reduced). 

SPRAY DRIFT 

Requirements for reducing spray drift for Diuron ground and aerial applications: 

Use best practices to avoid drift to all other crops and non-target areas. Do not apply when conditions 

favor drift from target areas. The interaction of many equipment- and weather-related factors determine 

the potential for spray drift. Avoiding spray drift at the application site is the responsibility of the 

applicator. The applicator must follow the most restrictive precautions to avoid drift, including those found 

in this labeling as well as applicable state and local regulations and ordinances. A drift control agent may 

reduce drift, however, it may also decrease weed control. 

Make aerial or ground applications only when the wind speed is less than or equal to 10 miles per hour. 

Do not make aerial or ground applications into temperature inversions. 

Filename: Thidiazuron-Diuron EC (333-RED 020507) ADOS! 508 RED + PR 2007-4 (Clean).doc 

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RED + PR Notice 2007·4 

Apply with medium or coarser spray (according to ASAE standard 572) for standard nozzles, 

Additional requirements for ground applications: 

When applying to crops, apply with nozzle height no more than 2 feet above the ground or crop canopy. 

When applying to non·crop areas, use lowest nozzle height consistent with safety and efficacy. Direct 

spray into target vegetation. 

Additional requirements for aerial applications: 

The spray boom should be mounted on the aircraft so as to minimize drift caused by wing tip vortices. 

The boom length must not exceed 75% of the wingspan or 90% of rotor blade diameter. 

Use upwind swath displacement. 

When applying to crops, do not release spray at a height greater than 6 to 10 feet above the ground or 

crop canopy. When applying to non·crop areas, apply at a minimum safe altitude above the area being 

treated. 

Do not apply by alr if sensitive non·target crops are within 100 feet of the application site. 

TIME OF APPLICATION 

THIDIAZURON·DIURON EC defoliant applications are to be made only on mature cotton plants when the 

uppermost harvestable boll is mature. Boll maturity is defined as 1) when a boll is squeezed between 

thumb and finger, it does not dent; 2) when cutting a cross section with a sharp knife is difficult; 3) when 

seeds in cross section lack liquid within the seed coat or outer edges of seed coat are light brown; and 4) 

when fully developed cotyledons are present. 

Make applications of THIDIAZURON·DIURON EC at least 5 days prior to expected harvest date. 

NOTE: Adequate defoliation with THIDIAZURON·DIURON EC depends on three factors: 

• Cotton is actively growing. 

• High relative humidity. 

• Cotton plant leaves are turgid and not desiccated. 

A ITENTION: Desiccation and/or leaf freezing may occur during periods of high temperature when 

adjuvants are added to THIDIAZURON·DIURON EC application solution. Products and adjuvants 

known to cause desiccation of cotton leaf tissue should not be used. , . ,.~~~ . • , , , ) , , > 

Under low nighttime temperatures (below 60°F) or otherwise adverse conditions, this pro(JU!~t, when llsed 

alone, may provide less than expected defoliation and / or regrowth suppression. ' 

APPLICATION INFORMATION " ' , .. Use an adequate volume of water with the recommended amount of THIDIAZUR0N·DIURC>N· Et: 

defoliant to uniformly and completely cover leaves. For ground equipment, apply 10 - 25 g3110n per acre 

and by air, use 2 -10 gallons per acre. Maintain agitation during application. " . , . ,,,. > ~ , ) > , 

, " 

" " DOSAGE INFORMATION 

Application Rate: Before harvest, use .075 Ibs ai/acre (.050 Ibs ai Diazuron/,Q25 Diuron) - O.1B'1" fbs 

ai/acre (0.125 lbs ai Diazuronl.062 Ibs ai Diuron) (6.4·16 fl. oz.lA of formulation). 

Maximum application rate of 0.3 Ibs ai/acre per year, Maximum of 2 applications, but not to exceed 0.3 

Ibs ai/acre per year. 

One gallon of THIDIAZURON-DIURON EC will treat 8 - 20 acres. Refer to the dose rate table below. 

In some situations, a follow-up application may be needed. THJDIAZURON-DIURON EC may be used for 

this application. Other defoliants may be needed. If additional boll opening is required, Ethephon 6 may 

be used at recommended rates; see product label for rates and timings. Consult your local State 

Extension Cotton Specialist recommendations for rates and timings. 

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RED + PR Notice 2007-4 

The maximum annual use rate ofTHIDIAZURON-DIURON EC is 16 oz. per acre per season. 

Maximum application rate of 0.3 Ibs ai/acre per year. Maximum of 2 applications, but not to exceed 0.3 

Ibs ai/acre per year. Minimum retreatment interval is 21 days. 

TANK MIX OF Thidiazuron-Diuron SC plus other cotton defoliant products: 

The tank mix of Thidiazuron-Diuron SC plus other cotton defoliant products is recommended to improve 

overall defoliation, and as an aid in accelerating the opening of mature, unopened cotton bolls. Best 

activity will be obtained where the tank mix is applied to mature cotton plants. Do not apply tank mix 

before sufficient unopened bolls have matured to produce the desired cotton yield. 

For cotton produced in non-arid conditions, apply Thidiazuron-Diuron SC at a rate of 3.2 to 6.4 fluid 

ounces per acre plus other cotton defoliant products at a rate of 21 to 42 fluid ounces per acre. 

For cotton produced in arid conditions, apply Thjdiazuron-Diuron SC at a rate of 6.4 to 16 fluid ounces per 

acre plus other cotton defoliant products at a rate of 21 to 42 fluid ounces per acre. 

MIXING INSTRUCTIONS 

1. Fill spray applicator tank with at least one half of the water to be used 

2. Start agitation 

3. Add the appropriate volume of THIDIAZURON -DIURON EC 

4. Continue agitation and fill tank with the remainder of the water to be used 

5. Agitation should continue throughout the application 

CALIFORNIA ONLY: PRECONDITIONING 

When used as a pre-conditioner seven to ten days before application of this or other defoliant 

compounds, this product will improve the efficacy of such a defoliant application. Before use, observe all 

product label directions, recommendations and prohibitions on both product's labels. 

Application Rate: Use 4-6 fl. oz. of this productfacre in an aerial application of 2-10 gallons of spray 

solution or ground application of 10-25 gallons of spray solution 

APPLICATION RATE TABLE for THIDIAZURON -DIURON EC 

THIDIAZURON-DIURON EC One Gallon of THIDIAZURON- Active Ingredients per Acre 

Formulated Product DIU RON EC Will Treat 

6.4 oz.lAcre 20 Acres 0.05 Ibs. ai/Acre 

(004 pUAere) , , " ,> " 

8.90z.lAcre 15 Acres 0.07Tbs.·~AYAcre , , , , (0.56 PuAcre) , , 

12.8 oz.lAcre 10 Acres 0.1 O"lbB.' AijAcre " , , (0.8 pUAere) , 

" '" , ~,6.0 oz.lAcre 8 Acres 0.125 !t£, .ai/Acre' " , , 

1.0 QUAere) , 

, , , --~,. 

" DO NOT APPLY MORE THAN 1,0 PINT OF THIDIAZURON-DIURON EC PER ACRE PER SEA~ON. . , ", , 

IMPORTANT CLEANOUT INSTRUCTIONS , ,", 

When applying THIDIAZURON-DIURON EC, a residue may form in application equipment. This residue 

can best be flushed out of the spraying system by using a commercial tank cleaner when done while 

residue is still fresh and moist. DO NOT ALLOW EQUIPMENT TO DRY BEFORE CLEAN OUT. Consult 

your State Extension Cotton Specialist for recommended lank cleaners and cleaning procedures. 

Use tank cleaner and waler immediately after application. Flush the entire syslem including nozzles, 

booms, application tanks, sumps, pumps, and transfer lines. Allowing the spray solution to dry in the 

application equipmenl can result in residues that are more difficult to remove. Dried residues are 

extremely difficult to remove. To remove such dried residues, fill the affected equipment to 

capacity with commercial tank cleaner solution and let it remain for 7 days. Afterwards, the 

equipment will need to be thoroughly flushed and rinsed. 

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Page 7 

14
RED + PR Notice 2007-4 

Spray application equipment that has been inadequately cleaned will contain residue of THIDIAZURONDIURON EC. Such improper cleaning could lead to crop damage in later applications. 

Arysta LifeScience North America, llC assumes no liability due to equipment that has not been 

properly cleaned. 

Warranty and Disclaimer Statement 

The direclions for use of this product are betieved 10 be adequate and musl be followed carefully. However, It is 

impossible to eliminale all risks associated with the use of this product. Such risks may arise from weather 

condltions, soil factors, Off-target movement, unconventional farming techniques, the presence of other materials, the 

manner of use or application, or other unknown factors, all of which are beyond the control of Arysta LifeScience 

North America, LLC ("Arysta'), and can cause crop injury, injury to non-targel crops or plants, ineffectiveness of the 

product, or olher uninlended consequences. All such risks shall be assumed by the user or buyer. Arysta warrants 

that this product conforms to the chemicat description on the label and is reasonably fit for the purposes stated in Ihe 

Directions for Use, SUbject 10 the inherent risks described above, when used in accordance w·lth the Direclions for 

Use under normal conditions. This warranly does not extend to the use of Ihis product contrary to label instructions or 

under condilions not reasonably foreseeable to Arysla, and is subject to the inherent risks described above. 

TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ARYSTA DISCLAIMS ALL OTHER WARRANTIES, 

EXPRESSED OR IMPLIED, INCLUDING ANY WARRANTY OF MERCHANTABtLiTY OR FITNESS FOR A 

PARTICULAR PURPOSE. TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, ARYSTA, 

MANUFACTURER, AND SELLER DISCLAIM AND SHALL NOT BE LIABLE FOR ANY SPECIAL, tNCIDENTAL, 

INDIRECT, OR CONSEQUENTIAL DAMAGES RESULTING FROM THE USE, HANDLING, APPLICATION, 

STORAGE, OR DISPOSAL OF THtS PRODUCT OR FOR DAMAGES IN THE NATURE OF PENALTIES, AND THE 

USER AND BUYER WAIVE ANY RIGHT THAT THEY MAY HAVE TO SUCH DAMAGES. NO AGENT, 

REPRESENTATIVE OR EMPLOYEE OF ARYSTA IS AUTHORIZED TO MAKE ANY WARRANTY, GUARANTEE 

OR REPRESENTATION BEYOND THOSE CONTAINED HEREtN OR TO MODIFY THE WARRANTIES 

CONTAINED HEREIN. 

TO THE EXTENT CONSISTENT WITH APPLICABLE LAW, THE EXCLUSIVE REMEDY OF THE USER OR 

BUYER, AND THE TOTAL LIABILITY OF ARYSTA, MANUFACTURER, AND SELLER, SHALL BE LIMITED TO 

THE PURCHASE PRICE PAID, OR AT ARYSTA'S ELECTION, THE REPLACEMENT OFTHE PRODUCT. 

Filename: Thidiazuron-Diuron Ee (333-RED 020507) ADOS1508 RED + PR 2007-4 (Clean).doc 

, ''',,' ,s' , , > • , , , , " , >, 

Page 8 

, , , . , , , > 

, " , , 

, , , > 

15
THIDtAZURON·DIURON EC 

COTTON DEFOLIANT 

For Agricultural Use Only 

ACTIVE tNGREDlENTS: Thidiazuron: N.phenyl-N'-1,2,3-thidiazol-5-ylurea· .. 

Diuron: 3-(3,4-dichlorophenyl)-1 ,1-dimethylurea· .... 

..12% 

..6% 

.. 82% 

.. 100% 

Other Ingredients: .. 

TOTAL. 

Contains 1 lb. Thidiazuron per gallon and 0.5 lb. Oiuron per gallon 

KEEP OUT OF REACH OF CHtLDREN 

DANGER - PELIGRO 

Si usted no entiende la etiqueta, busque a alguien para que se la expl"rque a usted 

en detalle. 

(tf you do not understand this label, find someone to explain it to you In detaiL) 

• • 

• • 

CLOTHING; • 

• • 

• • • 

gastric lavage. lfin eyes, 

eye open and rinse 

20 minutes. 

r" 

Remove contact lenses, if present, after the first 5 minules, 

then continue 

Rinse skin immediately with 

minutes. 

15-20 

If person is not brealhing, call 911 or an ambulance, then 

give artificlat respiration, preferably is 

treatment advice. 

Do not induce vomiting unless told to do so by a poison 

control center or doctor. 

or water if able to swallow. 

to an care. "" 

Have the product container or labet with you when. callL'1g a center or 

doctor or going for treatment. 

FOR 24-HOUR EMERGENCY MEDICAL CALi:.: 1-&53-303-6952 

FOR CHEMICAL EMERGENCY: Spill, leak, fire, call CHEMTREC 

1-424-9300 

STATEMENTS 

, -_ .. _--,- ........ - HAZARDS TO HUMANS AND UUMI:;' kl<" AruMA!..;' 

DANGER '" " 

Corrosive. Causes irreversible eye daruag;e. ski!) irfit?tiort DO:f'\.Ot get in eyes, on 

skin, or on clothing. " 

Filename: Tlridi'&zuron-Diurot! EC (333-REO 020507) AOOS 1508 REO + PR 2007-4 (Clean).doc 

ENVIRONMENTAL HAZAROS 

Do not apply directly to water, or to areas where surface wa

areas below the mean high water mark. Do not contamina

equipment wash water or rinsate. 

This product may contaminate water through drift of spray in 

hIgh potential for runoff for several months or more after appl

and soils with shallow water tables are more prone to prod

product. A tevel, well-ma'mtained vegetative buffer str'IP b

product is applied and surface water features such as pond

reduce the potential for contamination of water from runoff. 

reduced by avoiding applications when rainfall is forecaste

Sound erosion control practices will reduce this product's c

contamination. 

This chemical has properties and characteristics associated 

ground water. Use of this chemical in areas where soils are p

the water table is shallow, may result in groundwater contami

STORAGE ANDDtSposAt: 

Do not conlaminate waler, food, or feed by storage or dispo

PESTICIDE STORAGE: Store this producl in a cool, dry pla

only, Container should be closed when not in use. Do not e

flame excessive heat. Store in original container and keep c

PESTtCIDE DtSPOSAL: Pesticide wastes are acutely haza

of e:<cess pesticide, spray mixture, or rinsate is a violation o

wastes cannot be disposed of by use according to label inst

Pesticide or Environmental Control Agency, or the Hazardo

the nearest EPA Regional Office for guidance. 

CONTAINER DISPOSAL: Nonrefillable container. Do not r

Triple rinse container (or equivalent) promptly after emptying

Empty the remaining contents into applicalion equipment or 

seconds after the flow begins to drip. Fill the container Y. fu

Shake for 10 seconds. Pour rinsate into application equipm

rinsate for later use or disposal. Drain for 10 seconds after 

Repeat this procedure two more times. Offer for recycling, 

dispose of in san'ltary landfill, or by other procedures approv

authorities. 

PHYSICAL OR CHEMICAL HAZAROS Do not use or slore near heat or open flame. 

To Contain a Spin: Absorb liquid by covering ij with cat liUe

sand, sawdust, or soda ash. Once absorbed, bury the cleani

spill area with a detergent and water solution. 

DIRECTIONS FOR USE 

It is a violation of Federal law to use this product in a 

its labeling. 

SEE ATTACHEO BOOKLET FOR ADDITIONA

AND USE DtRECTlONS 

EPA Reg. No. 66330-333 ManufactUred for 

EPA Est No, 51036-GA-001 Arysta lifeScience 

AD081508 15401 Weston Par

____ __

BASE LABEL_ 

Page9 
Date: August 27,2009 

Reg. No.: 066330-333 

Product Name: Thidiazuron-Diuron Be 

PM NameINumber: Joanne Miller, PM 23 / 

/l/ ,.--/ .GO ,-LO--c. IV J J I c) /0 0; 

Primary Reviewer: Judy Loranger ~-a;, ij /~ AL-- f / ; I. 

Secondary Reviewer: Larry Schnaubelt L. .Y#~7 / 1;1'l; <>J 

New label or date ofRD amended label: New, Received on 116/09 

Fonnulation Type: Liquid 

Active Ingredient Assessed: Thidiazuronl120301 

Other ai's in product 

NamelPC code: 

Diuronl035505 

Noteta PM: 

• 

Reregistr:ation Status or Registration Date: 

Previous assessment attached. 

1) PRE notes that the label for this product does not include resistance management 

labeling as described in PR Notice 2001-5. The Agency encourages registrants to add the 

resistance management grouping symbols and statements to product labels in view of the 

importance of resistance management to a long-term pest management strategy. 

2) The respirator text appearing in the handler PPE section ("a NIOSH approved 

particulate filtering respirator equipped with N, R, P class filter media. The respirator 

should have a NIOSH approval number prefix TC-84A") differs from the respirator text 

required in the Diuron RED. The label assessor is uncertain whether this substitution is 

acceptable and defers to RD regarding this issue. 

3) For clarification, RMIBV suggests that the first paragraph of the spray drift text 

required in the RED and which appears on the label be revised to: 

"Thidiazuron products can not be applied by air within Y2 mile of lettuce or withia 5 miles 

upwind of citrus in flush (burst of new growth, as in springtime) in the Rio Grande valley 

of Texas. Ground applications are restricted to no less than 100 feet away from lettuce 

and no less than Y2 mile upwind from citrus." 

Also, this text should be moved from the Agricultural Use Requirements box and placed 

in the Spray Drift section. In addition, RMIBV recommends that the general prohibition 

"Do not apply by air if sensitive crops are within 100 feet of the application site" (page 6) 

be qualified with the addition of the phrase" ... except as noted for lettuce and citrus" 

since without qualification the text would conflict with the lettuce and citrus restrictions. 

1 

17
Assessment can be found N:\prb\label\066330/333a 

1) This product has been classified as a Restricted Use Pesticide due to eye irritation. 

Add the following text to the top of the front panel of the label, preferably enclosed in a 

box: 

Restricted Use Pesticide 

Due to eye irritation. 

For retail sale to and use only by Certified Applicators or persons under their direct 

supervision and only for those uses covered by the Certified Applicator's certification. 

The above text must be set in type of the same minimum size as required for human 

hazard signal words and appear with sufficient prominence relative to the other text and 

graphic material on the front panel to make it unlikely to be overlooked under customary 

conditions of purchase and use. 

2) Add "Restricted Use Pesticide" immediately below the heading "Directions For Use", 

3) Per the acute toxicity review and Thidiazuron and Diuron REDs, the handler PPE 

must be revised to read: 

"Some materials that are chemical-resistant to this product are made of barrier laminate 

or butyl rubber. If you want more options, follow the instructions for category B on an 

EPA chemical-resistance category selection chart. 

Pilots and flaggers must wear: 

Long-sleeved shirt and long pants, 

Shoes and socks. 

Mixers, loaders, applicators and other handlers must wear: 

Coveralls over short-sleeved shirt and short pants, 

Chemical-resistant shoes plus socks, 

Goggles or faceshield, 

Chemical-resistant gloves, 

Chemical-resistant headgear for overhead exposure, 

Chemical-resistant apron when mixing, loading, or cleaning equipment or spills, 

A NIOSH approved particulate filtering respirator equipped with N, R, or P class filter 

media. The respirator should have a NIOSH approval number prefix TC-84A. It is 

recommended that you require that the respirator wearer be fIt tested, and trained in the 

use, maintenance, and limitations of the respirator. 

See engineering controls for additional requirements." 

2 

18
4) Additional text in bold type must be added to the text: 

"Maximum application rate of 0.3 lbs ai thidiazuron per acre per year. Maximum of 2 

applications, but not to exceed 0.3 lbs ai thidiazuron per acre per year." 

Per the Thidiazuron RED, add "Maximum Thidiazuron application rate is 0.125 lbs ai/A 

(under normal conditions) or 0.21bs ai/A (under variable conditions)." 

3 

19
July 13, 2007 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF 

PREVENTION, PESTICIDES 

AND TOXIC SUBSTANCES 

MEMORANDUM: 

Subject: 

From: 

Through: 

To: 

DiuronRED 

Thidiazuron-Diuron EC Cotton Defoliant 

EPA Reg. No.: 66330-333 

Re: PRE Preliminary Label Assessment 

Judy Loranger (Signed/JL!7I24107) 

Product Reregistration Branch 

Special Review and Reregistration Division (7508P) 

Lawrence Schnauhelt (2"ILSI7!20107) 

Product Reregistration Branch 

Special Review and Reregistration Division (7508P) 

Joanne Miller, Product Manager 23 

Herbicide Branch 

Registration Division (7505P) 

20
SCOPE: The primary purpose of this preliminary label assessment is to determine 

whether or not the draft labels submitted in connection with product reregistration 

comply with amended labeling language specifIed in Chapter V of the subject 

RED/IRED. Product~specific data (product chemistry, acute toxicity, and in some cases 

efficacy data) were also required to be submitted or cited to support product 

reregistration. PRB's reviews of these data are appended to this assessment and may 

require additional revisions to the product label. 

BACKGROUND: The registrant has submitted 5 copies of draft labeling for the subject 

product in its 8-month response to the RED/IRED. PRB has completed a preliminary 

assessment of the draft labeling. A copy of this assessment may be accessed 

electronically on the LAN through the Q-Drive. The path is q:lprbllabeII066330/333. 

Note: In addition to the infonnation presented in this preliminary label assessment, 

Product ManagerlLabel Reviewers must apply their own knowledge of the subject 

product and the product's regulatory history (including comparison with existing stamped 

accepted labeling) to conduct a final review of the proposed label. It is the responsibility 

of the PM to obtain the necessary label improvements required for final product 

reregistration. 

Please note that this product contains multiple active ingredients. Additional label 

reviews will be necessary when the RED is issued for the other active ingredient 

(Thidiazuron.) 

PRB recommends that the PMs continue to follow the guidance provided in the Label 

Review Manual, including formatting suggestions presented in the sample labels in 

Chapter 3, to improve the quality and consistency of product labels. 

RECOMMENDATIONS: 

The subject product requires revisions to conform with the RED and acute toxicity 

review. Deficiencies are listed in the table below. Once these revisions have been 

submitted and approved by the PM, the PM may issue an amended registration. Since 

this product contains mUltiple active ingredients it may not be reregistered until a 

favorable registration eligibility decision is made for all active ingredients. At that time 

the more restrictive language must be adopted for the label. 

2 

21
Appendix I 

PRB Label Analysis For Compliance With Label Revisions Specified In the 

REDIIRED and/or Technical Reviews 

Label Requirement Acceptable Not Acceptable Comments 

Restricted Use Pesticide Per the acute toxicity review, this 

product meets the criterion for restricted 

use classification based on data that 

place it in toxicity category I for eye 

irritation. 

Ingredients Statement X 

Signal Word X 

First Aid X Based on toxicity ranking noted in the 

acute toxicity review, PRB recommends 

that the First Aid statements be placed 

on the label in the following order: 

"IF IN EYES ... 

IF ON SKIN OR CLOTHING ... 

IF INHALED ... 

IF SWALLOWED ... " 

Emergency Information X 

Note to Physician X PRB recommends that the Note to 

Physician be revised to address eye 

irritation concerns. 

Hazards to Humans and X Per the acute toxicity review, the 

Domestic Animals Hazards to Humans and Domestic 

Animals must be revised to read: 

"DANGER 

Corrosive. Causes irreversible eye 

damage. Causes skin irritation. Do not 

get in eyes, on skin, or on clothing." 

PPE X Per the acute toxicity review and the 

Diuron RED, and Page IO-I6 of the label 

review manual, the PPE section must be 

revised to read: 

"Some materials that are chemicalresistant to this product are made of 

barrier laminate or butyl rubber. If you 

want more options, foliow the 

instructions for category C on an EPA 

chemical-resistance selection chart. 

All pilots and flaggers must wear: 

Long-sleeved shirt and long pants, 

Shoes and socks. 

All mixers, loaders, other applicators and 

other handlers must wear: 

3 

22
Label Requirement Acceptable Not Acceptable Comments 

Coveralls over short-sleeved shirt and 

short pants, 

Socks plus chemical-resistant footwear, 

Chemical-resistant gloves, 

Goggles, face shield or safety glasses, 

Chemical-resistant apron when mixing, 

loading or cleaning equipment or spills, 

ond 

Chemical-resistant headgear for 

overhead exposure. 

In addition to the PPE above, all 

handlers except for ground boom 

applicators, pilots and flaggers must also 

wear a NIOSH-approved dust/mist 

filtering respirator with any N, R, P of 

HE filter or a NIOSH-approved 

dust/mist filtering respirator with 

approval number TC-2I c." 

Note to PM: 

The PPE specified in the RED has been 

revised as required in the acute toxicity 

review and the label review manual to 

require double layer PPE plus eyewear 

for all handlers including ground boom 

applicators. 

Engineering Controls X 

User Safety X Because coveralls are required for some 

Requirements handlers PRE recommends that the 

following text be added to the User 

Safety Requirements: 

"Discard clothing and other absorbent 

materials that have been drenched or 

heavily contaminated with this product's 

concentrate. Do not reuse them." 

User Safety X 

Recommendations 

Environmental Hazards X The phrase "For terrestrial Use" 

erroneously appearing on Page 5 of the 

Diuron RED label table and also on the 

label is confusing and should be deleted 

from the label. 

Physical and Chemical X 

Hazards 

WPS text X 

Non-WPS text N/A 

Storage and Disposal X 

Spray Drift Labeling X 

General Precautions and X 

Restrictions 

Application Instructions Per Page 12 of the Diuron RED, the 

following text was required for use on 

4 

23
Label R~quirement Acceptable Not Acceptable Comments 

cotton: 

"Apply a maximum of three applications 

per year." 

Minimum retreatment interval is 21 

days." 

Note to PM: PRB is uncertain whether 

these restrictions are appropriate/needed 

for this pre-harvest defoliant use and 

defers to RD regarding this issue. 

Other Comments NIA 

5 

24
DATE OUT: 171MAY/07 

SUBJECT: PRODUCT CHEMISTRY REVIEW OF: TGAI []: MUP []: EUP [xl 

BARCODE NO.: 339926 REG.lFILE SYMBOL NO.: 66330-333 

PRODUCT NAME: Thidiazuron~Diuron EC 

COMPANY NAME: Arysta LifeScience North America Corp_ 

FROM: Maria Rivera Piansay, Chemist 

Product Chemistry Team 

PRB/SRRD (7508C) 

TO: Barbara Briscoe, CRM 

Product Reregistration Branch 

Special Review and Reregistration Division (7S08C) 

INTRODUCTION: 

ACTION CODE: 675 

In response to our review of 5/1/07, Arysta LifeScience North America Corporation submitted revised basic and 

alternate formulation Confidential Statements ofFonnula (CSFs), both dated 5/8/07, "10 support of the reregistration of 

Thidiazuron-Diuron EC, EPA Reg. No. 66330-333. 

FINDINGS: 

I. Previously, the registrant was requested to clarify the inconsistency between the basic and the alternate 

CSF in declaring the purity of the The basic CSF declared 

wh ile the alternate claimed The registrant responded by submitting revised CSFs showing 

a different Diuron source. According to the current CSFs, the technical Diuron currently used in 

formulating this product is now , , with a purity of 

. With this revision, the CSFs are now found acceptable to support this product. The nominal 

concentrations of the active ingredients agree with that on the label, meeting PR Notice 91~2. The 

certified limits on the active and inert ingredients are acceptable as per 40 CFR 158.17S(b)(2). All 

ingredients Hsted on the CSFs are cleared for use in pesticide form1llations. 

2. The Ingredients statements are in compliance with the requirements of 40 CFR 156.1 O(g). The 

Physical or Chemical Hazards subheading is not triggered based on the physical/chemical 

characteristics ofthe product. The Storage and Disposal section of the label is acceptable in 

accordance with 40 CFR 156.10 (i)(2)(ix). 

CONCLUSIONS: 

The registrant has now satisfied product chemistry data requirements for the reregistration of EPA Reg. No. 

66330-333. 

M.R. Piansay and Cenlral File (EPA Reg. No. 66330-333) 

7508C:SRRD: PRB:CM-2: M.R.P .. (17/MA Y 107):703-308-8063 :<66330-333> 

25

*Product ingredient source information may be entitled to confidential 

treatment*
DATE OUT: OllMAY/07 

SUBJECT: PRODUCT CHEMISTRY REVIEW OF: TGAI [I; MUP [I; EUP [xl 

BARCODE NO.: 336741 REG.IFILE SYMBOL NO.: 66330-333 

PRODUCT NAME: Thidiazuron-Diuron Ee MRID NOS.: 462364-01. 462364-03, 462364-04 

COMPANY NAME: Arysta UfeScience North America Corp. ACTION CODE: 674 

FROM: Maria Rivera Piansay, Chemist 

Product Chemistry Team 

PRBISRRD (7508C) 

TO: Barbara Briscoe, CRM 

Product Reregistration Branch 

Special Review and Reregistration Division (7508C) 

INTRODUCTION: 

A Reregistration Eligibility Decision (RED), Case number 0046, was issued in September, 2003 for the Technical 

Grade Active Ingredient (TGAI) Diuron. According to the RED, the generic data base supporting the reregistration of 

Diuron have been reviewed and found to be substantially complete. 

In the 8-month response to the Diuron RED, Arysta LifeScience North America Corporation submitted a basic and an 

alternate formulation Confidential Statement of Formula (CSF), dated 2/5/07; a draft label, EPA received 2/8/07; and 

product chemistry data in MRID numbers 462364-0 1, 462364~03 and 462364-04. The registrant is requesting FIFRA 

Section 4 reregistration ofTbidiazuron-Diuron EC, EPA Reg. No. 66330-333. 

FINDINGS: 

1. EPAReg. No. 66330~333 is an end~use product that contains Diuron and Thidiazuron from registered 

sources (EPA Reg. No. 66330~324 and respectively) at label claim nominal concentrations of 

6.0% and 12.0%, respectively. 

2. The CSFs for the basic and the alternate formulations are not acceptable at this time because of an 

inconsistency in the purity of the The basic CSF declares 

while the alternate claims The registrant must clarify this discrepancy. 

3. The product chemistry data presented in MRID numbers 462364~01, 462364~03, and 462364~04 

are adequate and satisfy the product chemistry data requirements under Subgroups A and B 

which pertain to Product Identity, Composition and Analysis, and Physical and Chemical 

Properties, respectively. 

4. The Ingredients statements are in compliance with the requirements of 40 CFR 156.10(g). The 

Physical or Chemical Hazards subheading is not triggered based on the physical/chemical 

characteristics of the product. The Storage and Disposal section of the label is acceptable in 

accordance with 40 CFR 156.10 (i)(2)(ix). 

CONCLUSIONS: Except for Finding 2, the registrant has satisfied product chemistry data requirements 

for the reregistration of EPA Reg. No. 66330-333. 

TillS REVIEW CONTAINS F1FRA CBI 

26

*Product ingredient source information may be entitled to confidential 

treatment*
2 

REVIEW OF PRODUCT CHEMISTRY DATA: 

PRODUCT NAl\1E: Thidiazuron~Diuron EC EPA Reg. No: 66330-333 

Group A: Series 830-Product Identity, Composition, and Analysis (40 CFR158.155, .160, .165, .167, 

.170, .175 & .180). 

830~1550 Product Identity and Composition 

EPA Reg. No. 66330-333 is an end-use product produced through a non-integrated 

formulation system. The active ingredients Diuron and Thidiazuron are claimed in the label at 6,0% and 

12.0%, respectively. Description of materials used in the formulation oftbis product is found in MRID 

number 459373-01 and on the CSF. 

830-1600 Description of Materials Used to Produce the Product 

Refer to Confidential Appendix A. 

830-1620 Discussion ofFonnulation Process 

Refer to Confidential Appendix A. 

830-1670 Discussion of Fonnation ofhnpurities 

Refer to Confidential Appendix A. 

830-1700 Preliminary Analysis 

Refer to Confidential Appendix A 

830-1750 Certified Limits 

Refer to Confidential Appendix A. 

830-1800 Enforcement of Analytical Method 

The registrant cited a validated analytical method for the analyis ofDiuron and Thidiazuron (MRID 

number 468773-02). The active ingredients are extracted from the formulated product using methanol, and 

analyzed by HPLC with detection by UVNis absorption. 

This analytical method had been previously reviewed and accepted and determined to satisfy GRN 

830.1800. 

TillS REVIEW CONTAINS FIFRA CBr 

27
3 

Product Chemistry Data 

Subgroup A: Series 830.1550·830.1800 (40 CFR 158.155·158.180) 

GUIDELINE REFERENCE NO. MRIDNumber Data 

(GRN)f TITLE 830 Fulmled 

.1550 Product Identity and Composition 462364·04 Y 

.1600 Description of Materials Used to 462364·04 Y 

Produce the Product 

.1620 Descriotion of Fonnulation Process 462364·04 Y 

.1650 Discussion of Formation of 462364·04 Y 

Impurities 

.1700 Preliminary Analysis NfA NfA 

.1750 Certified Limits 462364·04 and CSF Y 

.1800 Enforcement Analytical Method 462364'()4 y 

Subgroup B: Series 830.6302 . 7950 (40 CFR 158.190) 

GUIDELINE REFERENCE VALUE OR 

NO. QUALITATIVE MRID Data Fulfilled 

(GRN)f TITLE 830 DESCRIPTION Number 

.6302 Color Amber 468773'()1 Y 

.6303 Physical State Liquid at 25°C 462364·01, ·03 Y 

.6304 Odor Amine 468773·01 y 

.6314 OxidationIReduction: Chemically stable to the action 462364·01, ·03 Y 

Chemical Incompatibility afwater, Iron powder, and 

Monoammonium phosphate 

The test material underwent a 

mild oxidation reaction in the 

presence of a potassium 

pennanganate solution. 

.6315 FlammabilitylFlame Y 

Extension >93 Q C 462364·01, ·03 

.6316 Explodability NfA NfA 462364·01, ·03 

28
4 

.6317 Storage Stability Post-storage (duplicate) 468773-02 y analyses of the product (oneyear, room-temperature 

storage) yielded Diuron results 

ranging from 5.92 to 6.18% 

with an average of 6.02%. 

Thidiazuron results ranged 

from 11.83 to 12.12% with an 

average of 11.96%. 

.6318 Viscosity 70 mpas @ 25°C 462364-01 Y 

64 mpas@ 25°C 462364-03 

.6320 Corrosion Corrosion testing was 468773-02 Y 

Characteristics conducted in combination with 

the Storage Stability testing. 

Product container (HDPE) 

retained its original condition 

after one year of storage at 

room temperature. 

.6321 Dielectric Breakdown N/A --- NlA 

Voltage 

.7000 pH 5.60@25°C 462364-01 Y 

5.46@25°C 462364-03 

.7300 Densitr;lRelative 

DensitylBulk ensity 0.9935 glmL@25°C 462364-01 Y 

0.9938 g/mL (a), 25°C 462364-03 

Explanations: Y = Requirement fulfilled; N = Requirement not fulfilled; N/A = Not applicable; G = Data gap 

THIS REVIEW CONTAINS FIFRA CBI 

29
5 

Confidential Appendix A 

M.R. Piansayand Central File (EPA Reg. No. 66330-333) 

7508C:SRRD:P RB:CM -2: M.R.P.: (0 lIMA Y f07):703M308-8063:<66330-333> 

THIS REVIEW CONTAINS FIFRA CBI 

30

Page 30 - *Manufacturing process information may be entitled to confidential treatment*
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

February 21,2007 

MEMORANDUM: 

Subject: 

From: 

To: 

Applicant: 

EPA Reg. No.: 66330-333/Thidiazuron-Diuron EC 

DP Barcode: 336474 

Case No.: 0046 

Marianne Lewis, Biologist [sign. M.Lewis 2121107] 

Product Reregistration Branch 

Special Review and Reregistration Division (7508C) 

Barbara Briscoe, CRM 

Product Reregistration Branch 

Special Review and Reregistration Division (7508C) 

Arysta LifeScience North America Corp, 

15401 Weston Parkway, Suite 150 

Cary, NC 27513 

FORMULATION FROM EPA Reg. No. 66330-333 LABEL: 

Active IngredientCs): 

OFFICE OF 

PREVENTION, PESTICIDES 

AND TOXIC SUBSTANCES 

% bywt. 

Diuron ............................................................................................................. ..... . 6.0% 

12.0% 

82.0% 

100.0% 

Thidiazuron ................................................................................. . 

Inert Ingredient(s): ................................................................................................ . 

Total 

31
BACKGROUND: In the 8 month response to the Diuron RED, the registrant has submitted acute 

toxicity studies to support the reregistration of their product, EPA Reg. No. 66330-333. The 

MRlD's are as follows: 468773-03 (81-1),468773-04 (81-2), 468773-05 (81-3), 468773-06 (81-

4),468773-07 (81-5), 468773-08 (81-6). The studies were conducted by Product Safety Labs. 

The test material used in each of the studies was the subject product. 

The primary eye irritation study (81-4) is self validated as Toxicity Category I therefore a full 

review of this study will not be conducted at this time by the Agency. 

RECOMMENDATIONS: 

• Five (81-1, 81-2, 81-3, 81-5, 81-6) of the acute toxicity studies submitted are acceptable to 

support the reregistration of EPA Reg. No. 66330-333. 

• The primary eye irritation study (81-4) is self validated as Toxicity Category L 

The acute toxicity profile for EPA Reg. No. 66330-333 is currently: 

Acute Oral IV Acceptable 

Acute Dermal IV Acceptable 

Acute Inhalation IV Acceptable 

Primary Eye I Self Validated 

Primary Dermal II Acceptable 

Skin Sensitization non sensitizer Acceptable 

NOTE: The acute toxicity requirements have been satisfied for the subject product. 

32
DATA REVIEW FOR ACUTE ORAL TOXICITY (§81-1, 870.1100) 

Product Manager: Jim Tompkins, 25 Reviewer: Marianne Lewis 

MRlD No.: 468773-03 Study Completion Date: 5115106 

Report No.: 19086 

Testing Facility: Product Safety Labs 

Author: G. Moore 

Quality Assurance (40 CFR §160.12): Included 

Test Material: Thidiazuron-Diuron Ee, amber liquid 

Species: Sprague-Dawley derived albino rat 

Age: young adult 

Weight: females = 194 - 233 

Source: Ace Animals, Inc. 

Conclusion: Up & Down Method 

1. LDso (mg/kg): > 5000 mgikg 

2. Toxicity Category: IV Classification: Acceptable 

Procedure (Deviations from §81-1): none 

Results: 

Test Sequence Animalld Dose Level Short term 

(mg/kg) outcome 

1 8256 5000 S 

2 8282 5000 S 

3 8283 5000 S 

S - SUrvIVal; D - death 

Long term 

outcome 

S 

S 

S 

Observations: 3/3 piloerection, 1/3 hypoactive, 1/3 anD-genital staining, all active and healthy 

from day 3 to end of study. 

Gross Necropsy: No observable abnonnalities noted 

33
DATA REVIEW FOR ACUTE DERMAL TOXICITY (§81-2, 870.1100) 

Product Manager: Jim Tompkins, 25 

MRID No.: 468773-04 

Reviewer: Marianne Lewis 

Study Completion Date: 5115106 

Report No.: 19087 

Testing Facility: Product Safety Labs 

Author: G. Moore 

Quality Assurance (40 CFR §160.12): Included 

Test Material: Thidiazuron-Diuron Be, amber liquid 

Species: Sprague-Dawley derived albino rat 

Weight: males ~ 328 - 343 g; females ~ 218 - 230 g 

Age: young adul t 

Source: Ace Animals, Inc. 

Summary: 

1. LDso (mg/kg): > 5000 mglkg 

2. Toxicity Category: IV Classification: Acceptable 

Procedure (Deviations From §81-2): none 

Results: Reported Mortality 

(number deaths/number tested) 

DOSAGE (mglkg) 

Males Females Combined 

5000 015 015 0110 

. ObservatIOns: Twenty four hours pnor to applrcatron of the test matenal the dorsal area and 

trunks were clipped free of hair. The neat test material was applied evenly over a dose area of 

approx. 2 x 3 inches (approx. 10% of total body surface) and covered with 2 x 3 inch 4~ply gauze 

pad. The pads and trunks were wrapped with a 3 inch Durapore tape. After 24 hours, the wraps 

and pads were removed and the test sites were gently cleansed. 

10110 exhibited erythema & edema, 7110 desquamation (lasting throughout the study) - apart from 

these signs all appeared active and healthy for the duration of the study. 

Gross Necropsy Findings: No observable abnonnalities were noted. 

34
DATA REVIEW FOR ACUTE INHALATION TOXICITY TESTING (§81-3, 870.1300) 

Product Manager: Jim Tompkins, 25 Reviewer: Marianne Lewis 

MRID No.: 468773-05 Study Completion Date: 5/15/06 

Report No.: 19088 

Testing Facility: Product Safety Labs 

Author: G. Moore 

Quality Assurance (40 CFR §160.12): Included 

Test Material: Thidiazuron-Diuron EC, amber liquid 

Species: Sprague-Dawley derived albino rat 

Weight: males ~ 316 - 326 g; females ~ 209·244 g 

Age: young adult 

Source: Ace Animals, Inc. 

Summary: 

1. LCso (mglL): > 2.01 mglL 

2. MMAD: 3.0 ~m GSD: 1.75 

3. Tox. Category: IV Classification: Acceptable 

Procedure (Deviation From §81-3): none 

Results: Reported Mortality 

Exposure (number deaths/number tested) 

Concentration Males Females 

0.52 mg/Lc3' 0/5 

2.01 mglL 2/5 liS 

Chamber Atmosphere 

Dose Level mgIL MMAD GSD 

0.52 2.8 ~m 1.75 

2.9 ~m 1.75 

2.01 2.9 ~m 1.72 

3.0 ~m 1.75 

combined 

3/10 

35
Chamber Dose Level rng/L Dose Level rng/L 

Environment 0.52 2.01 

Chamber Volume 150 L 150 L 

Airflow 45.7 45.7 

Temperature CC) 21- 22 21 - 22 

Relative Humidity % 42 - 68 42 -70 

Clinical Observations: 

Dose mg/l Time of Death Clinical Observations 

0.52 N/A 115 irregular respiration, dry rales, hypoactive, all active and 

healthy from day 2 to end of study 

2.01 3/10 on day 2 Reduced fecal volume, hunched posture, hypoactivity, irregular 

respiration, moist rales, facial staining, red ocular discharge, 6/10 

(survivors) lost weight during first half of study - all gained by end 

of studY 

Gross Necropsy Findings: 

Dose mglL Gross Necropsy Observations 

0.52 No observable abnormalities noted. 

2.01 Decedents: lungs slight edema, red intestines; survivors: no observable 

abnormalities noted 

36
DATA REVIEW FOR SKIN IRRITATION TESTING (§81-5, 870.2500) 

Product Manager: Jim Tompkins, 25 

MRID No.: 468773-07 

Testing Facility: Product Safety Labs 

Author: G. Moore 

Quality Assurance (40 CFR §160.12): Included 

Reviewer: Marianne Lewis 

Study Completion Date: 5115/06 

Report N<1.: 19090 

Test Material: Thidiazuron-Diuron Ee, amber liquid 

Dosage: 0.5 mL 

Species: New Zealand albino rabbit 

Age: yo~ng adult 

Sex: 3 males 

Weight: not given 

Source: Robinson Services, Inc. 

Summary: 

1. Toxicity Category: 11 

2. Classification: Acceptable 

Procedure (Deviations From §81-S): none 

Results: Twenty four hours prior to application of the test material the dorsal area and trunks 

were clipped free of hair. The test material was applied to one 6 cm2 intact dose site and covered 

with a I x 1 inch 4-ply gauze pad and wrapped with 3 inch Micropore tape. After 4 hours the 

pads and wrappings were removed and the test sites were cleansed. 

At I hr., 113 very slight erythema, 2/3 well defined erythema, & 3/3 very slight edema. From 24 

to 48 hrs., 2/3 well defined erythema, 1/3 moderate to severe erythema, & 3/3 slight edema. At 72 

hrs., 3/3 well defined erythema, 3/3 slight edema, & 2/3 hyperkeratosis. On day 7, 3/3 very slight 

erythema, 3/3 very slight edema, & 3/3 desquamation. On day 10, 3/3 very slight erythema, 2/3 

very slight edema, & 3/3 desquamation. By day 14, 3/3 very slight erythema & desquamation. 

37
DATA REVIEW FOR DERMAL SENSITIZATION TESTING (§81-6, 870.2600) 

Product Manager: Jim Tompkins, 25 

MRID No.: 468773·08 

Testing Facility: Product Safety Labs 

Author: G. Moore 

Quality Assurance (40 CFR §160.12): Included 

Reviewer: Marianne Lewis 

Study Completion Date: 5115106 

Report No.: 19091 

Test Material: Thidiazuron-Diuron Ee, amber liquid 

Positive Control Material: HCA historical control (PSL # 18271, 10-14-05) 

Species: Hartley albino guinea pig 

Weight: males ~ 297 - 380 g 

Age: young adult 

Source: Elm Hill Breeding Labs 

Method: Buehler 

Summary: 

1. This Product is a non sensitizer 

2. Classification: Acceptable 

Procedure (Deviation From §81-6): none 

Procedure: 

A group of animals were used to determine the highest non-irritating concentmtion (HNIC) of the 

test substance prior to the challenge dose. The HNIC for the test substance was detennined to be 

6% w/w mixture in mineral oil. 

The test animals were induced with 0.4 ml of75% test material in mineral oil once a week for 

three weeks using a Hill Top Chamber. Twenty four hours after each induction dose the animals 

were scored for irritation. Two weeks after the last induction dose, 0.4 ml of 6% w/w of test 

material in mineral oil was used to challenge the test animals. Twenty four and 48 hours after the 

challenge the animals were evaluated for sensitization. 

A group of ten animals were used as naive controls. These animals received only the challenge 

doses of the test material. 

38
Results: Due to irritation and residue adhesive from the tape the test sites were moved for the 

second and third induction doses. 

Twenty four hours after the first induction dose for the test materialMinduced animals, 5120 

exhibited very faint erythema and 12/20 faint erythema. After the second induction dose, 10/20 

exhibited very faint erythema and 6/20 faint erythema. After the third induction dose, 8120 

exhibited very faint erythema, 9/20 faint erythema, and 1/20 well defined erythema at the test site. 

Twenty four hours after challenge, 8/20 test material-induced animals exhibited very faint 

erythema. 

At 24 hours, in the naive control group of animals challenged with the test material, 411 0 

exhibited very faint erythema. 

39
ACUTE TOX ONE-LINER 

1. PC CODE: 035505 

2. CURRENT DATE: February21,2007 

3. TEST MATERIAL: Thidiazuron-Diuron Be, amber liquid 

Diuron: 6.0%, Thidiazuron: 12.0% 

Study/Species/ MRID# Results 

Lab/Study#lDate 

acute oral toxicity/ratIProduct 46877303 LD50> 5000 mglkg 

Safety Labs/19086/5-15-06 

acute dennal toxicity/rat! 46877304 LD50> 5000 mglkg 

Product Safety Labs/19087/ 

5-15-06 

acute inhalation toxicity/rat! 46877305 LD50> 2.0 I mgIL 

Product Safety Labs/19088/ MMAD ~ 3.0 ~m; GSD ~ 1.75 

5-15-06 

primary eye irritation/rabbit! 46877306 

Product Safety Labs/19089/ 

5-15-06 

primary dennal irritation/rabbit! 46877307 At I hr., 1/3 very slight erythema, 2/3 

Product Safety Labs/19090/ well defined erythema, & 3/3 very slight 

5-15-06 edema. From 24 to 48 hrs., 2/3 well 

defined erythema, 1/3 moderate to 

severe erythema, & 3/3 51 ight edema. 

At 72 hrs., 3/3 well defined erythema, 

3/3 slight edema, & 2/3 hyperkeratosis. 

On day 7,3/3 very slight erythema, 3/3 

very slight edema, 3/3 desquamation. 

On day 10, 3/3 very slight erythema, 2/3 

very slight edema, 3/3 desquamation. 

By day 14, 3/3 very slight erythema & 

desquamation. 

skin sensitization/guinea pig! 46877308 Non sensitizer 

Product Safety Labs/19091/ 

5-15-06 

Core Grade Key:A - Acceptable, S - Supplementary,U - Unacceptable,V - self~Vahdated 

Tax. Core 

Cat. Grade 

IV A 

IV A 

IV A 

I V 

11 A 

--- A 

40
LABELING: 

ID #: 066330-00333 THIDIAZURON-DIURON EC 

RESTRICTED USE CLASSIFICATION RECOMMENDED: 

Due to primary eye irritation toxicity category. 

SIGNAL WORD: DANGER PELIGRO 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS: 

Corrosive. Causes irreversible eye damage. Causes skin irritation. Do not get in eyes, on 

skin, or on clothing. Wear protective eyewear (goggles, face shield, or safety glasses), 

coveralls over short sleeved shirt and short pants, chemical resistant shoes, socks, and 

chemical resistant gloves (barrier laminate or butyl rubber, selection category B). When 

mixing and loading wear a chemical resistant apron. For overhead exposure wear 

chemical resistant headgear. When cleaning equipment add a chemical resistant apron. 

FIRST AID: 

IF IN EYES: Hold eye open and rinse slowly and gently with water for 15~20 minutes. 

Remove contact lenses, if present, after the first 5 minutes, then continue rinsing eye. Call 

a poison control center or doctor for treatment advice. 

IF ON SKIN OR CLOTHING: Take off contaminated clothing. Rinse skin immediately 

with plenty of water for 15-20 minutes. Call a poison control center or doctor for 

treatment advice. 

Have the product container or label with you when calling a poison control center or 

doctor or going for treatment. You may also contact 1-800-xxx-xxxx for emergency 

medical treatment infonnation. 

USER SAFETY RECOMMENDATIONS: 

User should wash hands before eating, drinking, chewing gum, using tobacco, or using the 

toilet. 

User should remove clothinglPPE immediately if pesticide gets inside. Then wash 

thoroughly and put on clean clothing. 

Users should remOve PPE immediately after handling this product. Wash the outside of 

gloves before removing. As soon as possible, wash thoroughly and change into clean 

clothing. 

41
The proposed label must contain the following guidance: 

NOTE TO PHYSICIAN: 

Probable mucosal damage may contraindicate the use of gastric lavage. 

Note to CRMIPMlRegistrant: 

The proposed label should contain a Note to Physician which addresses the primary eye irritation 

Toxicity Category I. The following statements are some suggested types of infonnation that could 

be included, if applicable, in the Note to Physicians: 

~ technical infonnation on symptomatology, 

- use of supportive treatments to maintain life functions; 

- medicine that will counteract the specific physiological effects of the pesticide; 

~ company telephone number to specific medical personnel who can provide 

specialized medical advice. 

42
PRODUCT REREGISTRATION 

SUPPORTING DOCUMENTATION 

FORM 

Case Name: .~ 

Registration No. aj"j~ -333 

This supporting documentation (in chronological order) includes: 

o Old labels (identified as "Superceded by label dated xx/xx/xx) 

o Unacceptable CSF (marked "Not acceptable" and dated) 

o Product chemistry reviews 

o Acute toxicity reviews 

o Efficacy and or special studies (if necessary) 

o 90-Day responses to PDCI (forms A and B) 

o Administrative forms (Application for Reregistration 

Celtification to Data citation, Data Matrix) 

o Correspondence (Company and Agency letters & e-mails) 

43
Please 1m Approved. OMS No. 2070·0060. Approval 

& EPA United States 

Environmental Protection Agency 

. DC 20460 

o Registration 

o Amendment 

Application for Pesticide - Section I 

2. 

opp Identifier Number 

o None 0 Restricted 

6. Expedited Review. In accordance with FIFRA Section 

Arysta LifeScience North America, LLC 

15401 Weston Parkway, Suite 150 

Cary, NC 27513 

(b)(I), my product is similar or identical in composition and labeling 

to: 

EPA Reg. No. ___________ _ 

Product Name _____________ __ 

Section -II 

Amendment - Explain below. Final printed labels in response to 

Resubmission in response to Agency letter dated __ 

Ii I I 

necessary. 

8~Month Response to Data Call-In dated May 8, 2008 for product containing thidiazuron. 

Yes~ 

No 

Yes 

Section - III 

poe 

*Certification must Unit Packaging 11111. container Package wgt. 

poe 

container 

IS] label D Container On label 

2.5 gal., 5.0 gal., and 30 gat. 

Section -IV 

BILL WASHBURN REGULATORY AFFAIRS MANAGER 

'" I certify that the statements I have made on this form and all attachments thereto are true, accurate and complete. I; 

acknowledge that any knowingly false or misleading statement may be punishable by fine or imprisonment or bolli' , . ~ 

under applicable law. 

REGULATORY AFFAIRS MANAGER 

BILL WASHBURN 1/5/09 

"" 

I I 

Paper 

Other 

" . 901-432-5118 

" 

44
Ut'u fED STATES ENVIRONMENTAL PROTEC I ION AGENCY 

401 M Street, S.W. 

WASHINGTON, D,C. 20460 

Form Approyed OMS No, 2070-006' 

PapelWork Reduction Act Notice: The public reporting burden for this collection of information is estimated to average 1.25 hours per response for 

registration activities and 0.25 hours per response for reregistration and special review activities, including time for reading the instructions and completing 

the necessary forms. Send comments regarding the burden estimate or any other aspect of this collection of information, Including suggestions for reducing 

the burden to: Director, OPPE Information Management DiYision (2137), U.S, EnYironmental Protection Agency, 401 M Street, SW., Washington, DC 20460. 

Do not send the form to this address. 

Certification with Respect to Citation of Data 

Applicant's!Registrant's Name, Address and Telephone Number EPA Registration Number! File Symbol 

Arysta LifeScience North America, LLC, 15401 Weston Pkwy, Ste 150, Cary, NC 66330-333 

Actiye Ingredient{s) andlor representative test compound(s); Date 

Thidiazuron, Diuron December 20, 2008 

General use pattem(s) (list all those claimed for this product using 40 CFR Part 158) 

Terrestrial, Non-Food Use (Cotton) 

Product Name 

THIDIAZURON-DIURON EC 

NOTE: If your product is a 100% repackaging of another purchased EPA·registered product labeled for all the same uses on your label, you 

do not need to submit this form. You must submit the Formulator's Exemption Statement{EPA Form 8570-27). 

o I am responding to a Data CalHn Notice, and have included with this form a list of companies sent offers of compensation (the Data 

Matrix form should be used for this purpose). 

SECTION I: METHOD OF DATA SUPPORT (Check one method only) 

o I am using the cite·all method of support, and have included with 

this form a list of companies sent offers of compensation (the 

Data Matrix form should be used for this purpose). 

[8J I am using the selectiye method of support (or cite-all option 

under the selectiye method), and have included with this form a 

comple~;d list of data requirements {the Data Matrix form must 

be used,. 

SECTION II: GENERAL OFFER TO PAY 

[Required if using the cite·all method or when using the cite·all option under the selective method to satisfy one or more data requirements] 

[2] I hereby offer and agree to pay compensation, to other persons, with regard to the approval of this application, to the extent required by 

FIFRA. 

SECTION III: CERTIFICATION 

I certify that this application for registration, this form for reregistration, or this Data Call-In Notice is supported by all data submitted 

or cited in the application for registration, the form for reregistration, or this Data Call·ln response. In addition, if cite·all option under the 

selective method is indicated in Section I, this application is supported by all data in the Agency's files that (i) concem the properties or 

effects of this product or an identical or substantially similar product, or one or more of the ingredients in this product: and (2) is a type of 

data that would be required to be submitted under the data requirements in effect on the date of approyal of this application if the 

application sought the initial registration of a product of identical or similar composition and uses. 

I certify that for each exclusiye use study cited in support of this registration or reregistration, that I am the original submitter or that 

I have obtained the written permission of the original submitter to cite that study. 

I certify that for each study cited in support of this registration or reregistration that is not an exclusiye use study, either: (a) I am 

the original data submitter: (b) I have obtained the written permission of the original data submitter to use this study in support of this 

applicaflon: (c) all periods of eligibility for compensation have expired for the study; (d) the study is in the publlc literature; or (e) I have 

notified in writing the company that submitted the study and have offered (i) to pay compensation to the extent required by sections 

3(c){1 )(F) andlor 3{c)(2){B) of FIFRA; and (ii) to commence negotiations to determine the amount and terms of compens'-lii~% !f~any, to be 

paid for the use of the study, ; , , , '~ , 

" , I certify that in all instances where an offer of compensation is required, copies of all offers to pay compensation and evidence of 

their delivery in accordance with sections 3(c){1 )(F) and!or 3(c)(2)(B) of FIFRA are available and will be suorrdtetllo the agegcy upon 

request. Should I fail to produce such evidence to the Agency upon request, I understand that the Agency ma'y,l\1liiate actj("ln Ip deny, 

cancel or suspend the registration of my product in conformity with FIFRA. , ) , ' , " ; 

I certify that the statements I have made on this form and all attachments to it are true, accurCi'te:c.nd' complete: I 

acknowledge that any knowingly false or misleading statements may be punishable by fine or imprisonment or bot;'~u~dor 

applicable law. ' '.:: 

Signature Date Typal orPrintal Name am Ti~e 

12/20/08 Bill Washburn, Regulatory Manager 

EPA Fonn 8570-34 (9·97) Electronic and Paper versions aYaitable, Sllbmlt only Paper yerslon. 

45
Form approved. OMB NO. 2070-0060. Approval E t:xpires 1-30-93 

United Slates Environmental Protection Agency 

ft Washington, D.C. 20460 

o EPA Formulator's Exemption Statement 

(40 CFR 152.85) 

Applicant's Name and Address EPA File Symbol/Registration Number 

Arysta LifeScience North America, LlC 66330-333 

Product Name 15401 Weston Parkway, Suite 150 THIDIAZURDN-DIURDN EC Cary, NC 27513 Date of Confidential Statement of Formula (EPA Form 8570-4) 

12/20/08 

As an authorized representative of the applicant for registration of the product identified above, I here certify that: 

(1) This product contains the following active ingredient(s): D!URON 

(2) Of these, each active ingredient listed in paragraph (4) is present so!ely as the result of the use of that active 

ingredient in the manufacturing, formulation or repackaging of another product which contains that active 

ingredient, which is registered under F!FRA Section 3, is purchased by us from another producer, and is labeled 

for at least each use for which my product is proposed to be labeled. 

(3) Indicate by checking (A) or (8) below which paragraph applies: 

k8J (A) An accurate Confidential Statement of Formu!a (EPA Form 8570-4) for the above identified product is 

attached to this statement. That formula statement indicates, by company name, registration number, and 

product name, the source of the active ingredient(s) listed in paragraph (1). 

OR 

D (B) The Confidential Statement of Formula (CSF) (EPA Form 8570-4) referenced above and on file with 

the EPA is complete, current, and accurate and contains the information required on the current CSF. 

(4) The following active ingredients in this product qualify for the formulator's exemption. 

Source 

Active Ingredient Product Name Registration Number 

Diuron 

Or 

· • " " , , · . '" · · · · · · .. '" ), . · · . · '" ' 

· · · · .. · · ,)) , 

• 

Signature Name and Tille Date 

G.:..,woo~ Bm Washburn, 1/3/09 · Regutatory Manager 

EPA Form 8570 -27 (Rev. 7 -91) White -EPA copy Yellow -Applicant copy 

46

*Product ingredient source information may be entitled to confidential treatment*
PRODUCT REREGISTRATION 

SUPPORTING DOCUMENTATION 

FOR 

Case Name:_~~~_______ ___ ... 

This supporting documentation (in chronologicol oreJer) 

includes 

Old labels (Identdied 05 "Superceded bv /ot)ef (jc/eo' fJ,'xx/!~ ,J 

" Unacceptable C:SFs [morkeo 'Not Accept')/)!e unci ciCJteO) 

u Product chemistry reviews 

Acute Toxicity reviews 

j Efficacy reviews (if necessary) 

(!? 90-day responses to PDC I if orrn f., ono form B) 

,~ Administrative forms (Application lor Rer8Qlstr01ion, CerlillcoliO(l 

to [Jato Cltotlon, Dolo Motrc.:) 

Il COtrespondence 

47
Material to be added to a Mini-Jacket 

(in the case where an e-Jacket exists) 

Reg. No. 

Send to SIG: check box 0 

This material is: 

€ New stamped-accepted label 

€ NewCSF 

€ Notification 

€ Final Printed Label 

€ Other: 

Instructions: Attach this notice on top of the 

material. It must be clipped all together and 

there should be NO STAPLES in the material. 

Then give the material with this coversheet to 

staff in the Information Services Center (Room 

230). 

Reviewer's Name: 

Phone: _____ Division: ___ _ 

CUrrent as of Monday, July 10, 2006 

48
~ "~~;;::~~~~=i'O====7r====02IE~i6Qii,,cc~~I----, ~ 

C> I";~~~;~ C> 

C> 

"-

49
Certifier! Mail Provides: ~ A m8,(ing ",e~ipt 

ill /\ Sig"3IW" '!Pen de;'v~rl 

III A reCOICl Of del"_'e'Y kcel 1>\' !hi' Pw,~' S0Cv'ce for I'NG Y":l<S 

ImDort'mf Remindars: l!! -C~r:':;t(l ;,1~': "'"y CHLY '.", '~'C" ,\,~",,,(j " .. ,i\~ F,"~t-C: lSS ",!ai! o! Pr,onty tv1ail. 

2 CO'n'i'2d r.I'!!: ':, "ot ')\'C,::1cO;,. 'e" C),','i :)a~:; 0A ',',Y"-,, ,C1'.',M,'" rC,3:~ 

• 

CCVERN:;C0 IS P?O',!iDEf) 

;M;r;,0 ;J.'-,:, O!,I 'if':" (; e, F[(' wt~!Gl) 

IJt' kstc:C!c'rJ :0 trw Jdd'B,)3e'a Or 

c'" ,',l;;" 'n;:;'" !h~ rn<lrlplEOe "lith the 

IMPORTANT: S<l'J8 Hiis receipt and present jj wilen making an inqui/Y. 

50
SYMBOL 

SURNAME 

DATE 

) 

UNITED STATES EHVIRONMENTAL PROTECTIOH AGEHCY 

CERTIFIED MAIL 

Mr. Bill Washburn, Regulatory Affairs Manager 

Micro Flo Company 

P.O. Box 772099 

Memphis, TN 38117 

'.-

SUBJECT: Diuron, Reregistration Eligibility Decision, (RED), Product Specific Data Call In 

Notice, Deficient Response to Data Ca1i in Requirements 

EPA Registration Number 51036-429 (transferred to 66330-33) 

Dear Mr. Washburn: 

This letter serves as notification to you that Micro Flo Company is not in compliance with the 

Diuron RED, Product Specific Data Call In Notice. SpecificalIy, you failed to submit copies of the 

Confidential Statement of Fonnula for your product. Additionally, you are required to submit revised 

copies of draft labeling and Application for Reregistration (Fonn 8570-1) which reflects the transfer of 

your EPA Registration Number 51036-429 to EPA Registration Number 66330-33. 

The fonns are available on the EPA website, hUp://www.epa.gov!opprdOOllforms. You must 

submit the data indicated above within ten days from your receipt of this letter. A Notice of Intent to 

suspend your Diuron product, EPA Reg. Number 66330-33 may be issued if you fail to meet this time 

frame. If you have any questions, please contact Barbara Briscoe at 703-308-8177. 

Sincerely, 

Linda S. Propst, Chief 

Product Reregistration Branch 

Special Review and Reregistration Division 

COHCUItRIHC!$ 

................. d ::U.. 9.J{.!;: ............... .. .................................. _ ................. u .................................. . 

.................. ... :',.-. ;.~7: ................. . 

ljft~' 

. ............. ~ .. ................... _............... ._ ............ .. ................. 51
IY1oI80L. 

IUAHAME 

"ATE 

CERTIFIED MAIL 

Mr. Bill Washburn 

Regulatory Affairs Manager 

MAY 3 2007 

Arysta Life Science North America Corporation 

15401 Weston Parkway, Suite 150 

Cary, NC 27513 

SUBJECT: Diuron, Reregistration Eligibility Decision (RED) Review of Product Chemistry Data, 

EPA Registration Number 66330-333 

Dear Mr. Washburn: 

This letter is in regard to your submission of product chemistry data in response to the Diuron (RED) 

Product Specific Data Call-In Notice. The Agency has made the following detenninations: 

• The Confidential Statements of Fomlula, (CSF) for the basic and alternate fonnulations dated 

February 5, 2007 are not acceptable at this time because of an inconsistency in the purity of the 

The basic CSF declares while the 

alternate claims You must clarify this discrepancy. 

• The data you submitted in MRlD numbers 46236401, 46236403 and 46236404 are adequate and 

satisfy the product chemistry data requirements under Subgroups A and B which pertain to 

Product Identity, Composition and Analysis, and Physical and Chemical Properties. 

• The Ingredient statements on the draft label are in compliance with the requirements of 40 CFR 

156.10(g) and PR Notice 91-2. The Physical or Chemical Hazards subheading is not triggered 

based on the physical/chemical characteristics of the product. The Storage and Disposal section 

of the label is acceptable in accordance with 40 CFR I56.1O(i)(2)(ix). 

You are required to submit revised CSF(s) within 10 days from your receipt of this letter. Failure to 

submit this data within this time frame may result in your receiving a Notice of Intent to Suspend your 

product. A copy of the Agency's Data Evaluation Record is enclosed. If you have any questions, 

regarding this letter you may contact Barbara Briscoe at 703-308-8177. 

_.~!1. ....... ~ !:PE.K~ ................. ,,z 

... ~/ill)\· l-:Sl:~~ ................. JJ; 01 

Sincerely, 

Linda S. Propst, Chief 

Product Reregistration Branch 

Special Review and Reregistration Division 

COHctJllUtlHetS 

. .................. ............. 08 ....... ............... H • 

.................. . ................ .._ .............. ... -............. ................ -

................. 

................. 

EAA Fonn 1320-tA (tlQO) OF FICIAL FILE COPY 

"U.$.~P""""OOfb: 11182- s:zo.8W4007 

52

*Product ingredient source information may be entitled to confidential 

treatment*
Please read instructions on reverse before campl<- J form. , .... rm Approved, OMB No. 2070-0060, Approval 

e,,',., 

- EPA United States D Registration opp Identifier Number 

0 Environmental Protection Agency D Amendment 

Washington, DC 20460 Other: 

A for Pesticide - Section I 

~ cl Nombe, 

~ 3. I 

; EC ~~. o None o Restricted 

5. N,me '" oof " " (tooode 

(b)(I), my product is si;":~ar or identical in ~:~position ~n~ ~{,c)~~~~ Arysta UfeScience North America Corporation to: 

15401 Weston Parkway, Suite 150 EPA Reg. No. 

Cary, NC 27513 

o Check if this is a new address 

Product Name 

Section - II 

Amendment - Explain below. Final printed labels in response to Agency lettel dated 

Resubmission in response to Agency tetter dated 5/3/07 J "Me Too" Application 

, - E'pl,'o below. I Other - Explain below 

Explanation: Use additional if necessary. (For i 1 I and 1 II.) 

Resubmission on response to Agency letter dated 513107. Clarification of source of active on Alternate 

Formulation dated 51S107. Source corrected to 

Section - III 

I-~ ~ , ~I" Soloble "--,Type 8'ye,' F Yes y., Metal 

No No 

"~ Plastic 

u~~e.,s:' wgt. No. 'p~r No. per Gtass 

*Certification must , wgt. container Paper 

be submitted I Olhe, , I 4. 81,e(,) " ~"' o label o Container F On label 

00 ~be"og , ""dool 

6. Manner in Which label is Affixed to Product , D Other ! P,pe; ,'oed 

I 

Section -IV 

; Poiol ybefow ,flo be , 

N~7~L WASHBURN 

ITHle c~~~i ; No. (Ioolode "'eo 

REGULATORY MANAGER 

901-432-5118 

~"'" I , ,,6. Ii 

I the statements I have made on this form and all aUachments thereto are true, accurate and complete. j J. I that any knowingly false or misleading statement may be punishable by fine or imprisonment or both ,(StaQ'ped) 

JJ"" 

, 2. 

~;~~LATORY MANAGER ) , , , 

(6;:,u, C ~r, - I. O. ," , 

~,~i"::::s~eBURN 5. Dote , 

May 10, 2007 '''.' , " , "';.' , 

EPA I IR". 8-94) : , Wh;'.- EPA FII. , I YOlld,,- I 'Copy 

53

*Product ingredient source information may be entitled to confidential 

treatment*
e Arysta LifeScience 

May 10, 2007 

Ms. Linda S. Propst 

Product Reregistration Branch 

Special Review and Reregistration Division 

Office of Pesticide Programs - 7508P 

U.S. Environmental Protection Agency 

One Potomac Yard (South Building), Room S-4400 

2777 South Crystal Drive 

Arlington, VA 22202 

Subject: Thidiazuron-Diuron EC 

EPA Reg. No. 66330-333 

Response to Agency Letter dated May 3, 2007 

Dear Ms. Propst: 

Having completed my review afthe Alternate CSF dated February 5, 2007, it appears 

that the source of the active ingredient diuron was not identified properly. The source for 

the diuron has been properly identified on the enclosed Alternate Confidential Statement 

of Formula dated May 8, 2007. 

Should you have any additional questions in regards to this formulation, please do not 

hesitate to contact me at 901-432-5118 or at bill.washburn@arystalifescience.com. 

Sincerely, 

Bill Washburn 

Regulatory Manager 

j )', 

Arysta LileSc1ence North America Corporation 

15401 Weston Parkway. Suite 150. Cary. NC USA 27513 Telephone: (+ 1) 919-678-4900 Fax: (+ 1) 919-678-2194 

www.arystalifescience.com 

> > , 

> 

, " " 

'" ) 

54
I 

ysta LifeScience 

:ebruary 6, 2007 

Ms. Linda Propst 

Document Processing Desk 

Product Reregistration Branch/SRRD 

Office of Pesticide Programs - 7508P 

U.S. Environmental Protection Agency 

One Potomac Yard (South Building), Room S-4400 

2777 S. Crystal Drive 

Arlington, VA 22202 

Subject: Thidiazuron-Diuron EC 

EPA Reg. No. 66330-333 

Response to Agency Letter Dated January 25, 2007 

Dear Ms. Propst: 

Per your instruction in the letter referenced above, I am resubmitting for your review the 

following documents: 

• 2 Copies - Confidential Statement of Formula - Basic Formulation 

• 2 Copies - Confidential Statement of Formula - Alternate Formulation 

• One Copy - Revised Formulator's Exemption Statement 

• 5 Copies - Revised labeling to reflect change in ownership. 

Should you find that you require any additional information to support the reregistration 

of this product, please do not hesitate to give me a call at 901-432-5118 or e-mail me at 

bill.washburn@arystalifescience.com. 

Sincerely, 

Bill Washburn 

Regulatory Affairs Manager 

Arysta LifeScience North America Corporation 

15401 Weston Parkway, Suite 150, Cary, NC USA 27513 Telephone: (+1) 919-678-4900 Fax: (+1) 919-678-2194 

www.arystalifescience.com 

55
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MICRO-FLO COMPANY LLC 

530 OAK COURT DRNE 

MEMPHIS, TN 38117-

July 7,2006 

Report of Analysis for Compliance with PR Notice 86-5 

OFFICE OF 

PREVENTION, PESTICIDES AND 

TOXIC SUBSTANCES 

Thank you for your submittal of 03-JUL-06. Our staff has completed a preliminary 

analysis of the material. The results are provided as follows: 

Your submittal was found to be in full compliance with the standards for submission of 

data contained in PR Notice 86-5. A copy of your bibliography is enclosed, annotated with 

Master Record ID's (MRIDs) assigned to each document submitted. Please use these numbers in 

all future references to these documents. Thank you for your cooperation. If you have any 

questions concerning this data submission, please raise them with the cognizant Product 

Manager, to whom the data have been released. 

56
MICRO.·J, .... FLO 1llEPl.iNrHill1HAND~ COMPANY 

June 30, 2006 

Document Processing Desk (DCI/SRRD) 

Ms. Karen Jones, Chemical Review Manager 

Product Reregistration Branch 

Special Review and Reregistration Division - 7504P 

Office of Pesticide Programs 

U.S. Environmental Protection Agency 

One Potomac Yard (South Building) 

2777 S. Crystal Drive 

Arlington, VA 22202 

Dear Ms. Jones 

Subject: Thidiazuron·Diuron EC 

EPA Reg. No. 51036-429 

Data Call·ln 8·Month Response 

Please find enclosed Micro Flo's 8-Month Response to the Product Specific Data 

Call-In for products containing the active ingredient diuron. The following 

materials are included in this submission: 

1.) Application for Registration 

2.) Data Matrix - Agency and Public Copies 

3.) Requirements Status and Registrant's Response - REVISED 

4.) Data Waiver Request 

5.) Five (5) copies of Draft labeling 

One Highlighted Copy and Four (4) Clean Copies 

p.o. 80x 772099 • Memphis, TN 38117-2099 • Office: 901-432-5000 • Fox: 901-432-5100 

468773.00 

57
Ms. Karen Jones 

Thidiazuron-Diuron EC 

June 30, 2006 

page 2 

Also submitted in support of this application are three copies of the following 

data, which are enclosed: 

1.) PhYSical Properties of Thidiazuron-Diuron EC, EPA OPPTS Guideline 

Reference Number 830.6302 and 830.6304, 9 pages 

Laboratory Project ID: MI-0601 MRID No. 46877301 

2.) Storage Stability of Thidiazuron-Diuron EC (C) with Corrosion 

Characteristics, EPA OPPTS Guideline Reference Number 830.6317 and 

830.6320, 10 pages 

Laboratory Project ID: MI-0406 MRID No. 46877302 

3.) Thidiazuron-Diuron EC: Acute Oral Toxicity Up and Down Procedure in 

Rats, EPA OPPTS Guideline Reference No. 870.1100 (2002), 14 pages. 

Laboratory Study No. 19086 MRID No. 46877303 

4.) Thidiazuron-Diuron EC: Acute Dermal Toxicity Study in Rats - Limit Test, 

EPA OPPTS Guideline Reference No. 870.1200 (1998),14 pages 

Laboratory Study No. 19087 MRID No. 46877304 

5.) Thidiazuron-Diuron EC: Acute Inhalation Toxicity Study in Rats -LCso, 

EPA OPPTS Guideline Reference No. 870.1300 (1998), 30 pages 

Laboratory Study No. 19088 MRID No. _46_8_7_73_0_5 __ 

6.) Thidiazuron-Diuron EC: Primary Eye Irritation Study in Rabbits, EPA 

Guideline Reference No. 870.2400 (1998), 17 pages 

Laboratory Study No. 19089 MR 

46877306 IDNo. ____ _ 

7.) Thidiazuron-Diuron EC: Primary Skin Irritation Study in Rabb'ls, E"A 

Guideline Reference 870.2500 (1998),15 pages 

Laboratory Study No. 19090 MRID No. 48877307 --

58
Ms. Karen Jones 

Thidiazuron-Diuron EC 

June 30, 2006 

page 3 

8.) Thidiazuron-Diuron EC: Dermal Sensitization Study in Guinea Pigs 

(Beuhler), EPA Guideline Reference No. 870.2600 (2003), 22 pages 

Laboratory Study No. 19091 MRID No. 46877308 

If you have any questions with respect to this submission please do not hesitate 

to contact the undersigned at 901-432-5118. 

Sincerely, 

2~~C/o~ Bill Washburn 

Regulatory Affairs Manager 

59
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY Form A

401 M Street, S.w. 

WASHINGTON, D.C. 20460 

Paperwork Reduction Act Notice: "[tee public repc.1:n'ij bUrdENl for trllS collection of information is estimated to average 0.25 hours per response for registration activitie

reregistration and speciat review activi!ies,Jnctuding liri1e br instructions and compteting the necessary forms. Send comments regarding the burden estima

of information, including suggestions.for reducing OPPE Information Management Division (2137), U.S. Environmental Protection Agency, 401 M 

Do not send the form to this address: - ' 

DATA MATRIX 

Date June 29,2006 EPA Reg. No.lFileSymbol 51036-429 

Applicant's/Registrant's Name & Addri;:!ss: C • • • - : Product 

Micro Flo Company LLC, P,O. BOk 1'7:20:19, Memphis, TN 38117 Thidiazuron-Diuron EC 

lngredient{s): Thidiazuron, CAS Reg. and Dluron, CAS Reg. 

Guideline Reference Number Guideline Study Name MRID Number Submitter Status 

830.1550 Product Identity and Composition 46236402 Micro Flo Company LLC 

46236404 

830. t600 Description of the Materials Used to Produce 46236402 Micro Flo Company LLC 

the Product 46236404 

830.1650 Description of the Manufacturing Process 46236402 Micro Flo Company LLC 

46236404 

830.1670 Discussion of Fonnation of Impurities 46236402 Micro Flo Company LLC 

46236404 

830.1750 Certified Limits 46236402 Micro Flo Company LLC 

46236404 

830.1800 Enforcement Analytical Method 46236402 Micro Flo Company LLC 

46236404 

830.6302 Color Micro Flo Company LLC 

830.6303 Physical State 46236401 Micro Flo Company LLC 

46236403 

830.6304 Odor Micro Flo Company LLC 

830.6314 Oxidation/Reduction: Chemical Compatibility 46236401 Micro Flo Company LLC 

46236403 

830.6315 Flammability 46236401 Micro Flo Company LLC 

46236403 

830.6316 Explodability 830.6317 Storage Stability Micro Flo Company LLC 

830.6319 Miscibility Micro Flo Compan LLC 

830.6320 Corrosion Characteristics Micro Flo Company LLC 

830.6321 Dielectric Breakdown Voltage Micro Flo Company LLC 

830.7000 pH 46236401 Micro Flo Company LLC 

46236403 

830.7100 Viscosity 46236401 Micro Flo Company LLC 

____ ______ __ __ 

Signature Name and Title: Bill Washburn, Regulatory Affairs Manage

EPA Form 857d·35 t9.97) Eleol,onlc and Paper versions available. Sub",1 only Paper VerslOfl. 
- UNITED STATES ENVIRONMENTAL PROTECTION AGENCY Form A

o 

I 

401 M Street, S.W. 

WASHINGTON, D.C. 20460 

n Act Notice:.T.'l::l public repcr:ii-lg burger:! for 'lhis COllection of information is estimated to average 0.25 hours per response for registration acti"ilIe

-'al review activtttes.)ncluding !ime,for,re;;'dih!fthe instructions and comn1o>linn th<> f"""" C:"nn (,rlm."""I", ,,,n,,,rlinn .... - .......... _- 

-,.-._ .... ., ... - ---------, -- ... _. ----- -- ------.---.-.,-.-... ---_ .... - 

_ S. IOf reaucmg 1I;.e I:!"urder.:to: D[":"ec!or, DPPE Information Management Division (2137). U.S. Enl,'ironmenlal Protection Agency, 401 M 

n to this -

DATA MATRIX 

JUne 29, 2006 EPA Reg. Symbol 

. , ...... ,icant's/Registrant's Name & Addless: " , ' .. - '. " I Micro Flo Company LLC, p,O, Bfr.<-7-T2W9, Mempnis, TN 38117 

Ingredient(s): Thidiazuron, CAS Reg. 51707*55.2, and Diuron, CAS Reg. 330·54*1 

O.lU./.lUU 

870.11 870. 870. 

870, 870, I Skin: 

yName 

elative D 

1 Tax' 

'tatior 

I MRID 

I 46236401 

Product 

n EC 

- - - -- ---'" I I 

Micro Flo Company LLC ! Micro ! Micro Micro Micro Micro Micro 

Co. Co. 

.C 

Bill Washburn, Regulatory Affairs Manage
o 

- UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

401 M Street, S.W. 

Form A

WASHINGTON, D.C. 20460 

to average 0.25 hours per response for registration activitie

and completing the necessary forms. Send comments regarding the burden estima

0" OPPE Information Management Division (2137), U.S. Environmental Protection Agency, 401 M 

DATA MATRIX 

Date June 29, 2006 No.lFile 51036-429 

Product 

Flo Company LLC, P.O. Memphis, TN 38117 

Ingre(!ient(s): Thidiazuron, CAS Reg. and Diuron, CAS Reg. 330·54-1 

Signature Name and Title: 

Bill Washburn, Regulatory Affairs Manage

EPA Form 6570·35 (9'S7) Ele(:lron;c <lfid iiaper VB!soons a""ilable. Submii";;niy Paper 
.".. 

o 

roe 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

401 M Street, S.W. 

WASHINGTON, D.C. 20460 

the necessary forms. 

Management Division (2137). U.S. 

DATA MATRIX 

Form Ap

burden estimat

Protection Agency, 401 M 

Date June 29, 2006 EPA Reg. NoJFile Symbol 

Product 

Flo Company LLC, P.O. Box 772099, Memphis, TN 38117 

Ingredient(s): Thidiazuron. CAS Reg. and Diuron, CAS Reg. 330-54·1 

Signature Name and Title: 

Bill Washburn, Regulatory Affairs Manager 

EPA Fo.m8SiO:35 19-971 Eleclronicaiid ?ape;-v..-sions available. Subrriiioiii;;-Paper veml",,_ 
United States Environmental Protection 

Agency Washingt<Jn, D.C. 20460 

H.EQU'HElVt1l!,!TS STATUS AND REGISTRANT'S RESPONSE 

" " 

tSTRUCTIONS: Please type or:;:'rint in ink. PI('ai:"l reae c;::retul!:: the attached instructions and supply the information requested on this form. 

se addilional sheel(s) if necessa'ry. - " " 

. Company Name and Address " " 2. Case # and Name 3. Date and Type of DCI and 

" " 

MICRO-FLO COMPANY LLC " " " -

.. '. 0046 oiuron 28-0ct-200S 

- " 

530 OAK COURT DRIVE " - PRODUCT SPECIFIC 

MEMPHIS. TN 38117 10 # PoCI-035S0S-246

EPA Reg. No. 51036-429 

Gl(ldeline 5. Study Title' p 6. Use R Progress 7. Test 

equirement 0 Pattern Substance 

limber T Reports 

0 

C 

0 

l 1 2 3 

Product Ch!)mi§tr)! D<!t<! Beguiremgnjl;! (J:;Q!]vention<!! 

Chemical) 

1O.1550 Product Identity and composition (28) A, B, C, D, E, F, G, H, J, TGAl/MPfEP 

J, K, L. M, N, 0 

10.1600 Description of materials used to produce the product (29) A, B, C, D, E, F, G, H, J, TGAJlMPfEP 

J,K,L,M,N,O 

1O.1620 Description of production process (30) A, B, C, D, E, F, G, H, J, TGAI 

J, K, L. M, N, 0 

10.1650 Description of formulatlon process (31) A, B, C, 0, E, F, G, H, J, MPfEP 

J, K, L, M, N, 0 

)0.1670 Discussion of formation of impurities (32) A, B, C, D, E, F, G, H, I, TGAIfMPfEP 

J, K, L, M, N, 0 

10.1700 Preliminary analysis (33,34,35) A, B, C, 0, E, F, G, H, J, TGAI 

J, K, L, M, N, 0 

;0.1750 Certified limits (36,37) A, B, C, 0, E, F, G, H, I, TGAI/MP/EP 

J,K,L,M,N,O 

10, t800 Enforcement analytical method (38) A, B, C, 0, E, F, G, H, I, TGAlfMPfEP 

J, K, L, M, N, 0 

10.6302 Color (13) A, B, C, 0, E, F, G, H, I., TGAl/MPfEP 

J,K,L,M,N,O 

10.6303 Physical state (16) A, B, C, 0, E, F, G, H, I, TGAlfMP/EP 

J, K, L, M, N, 0 

1. Certification I certify t at the statements made on this form and all attachments are true, accur te, and complete. I acknowledge that any 11. Date r,,!jO

10wingly false Dr misleading statement may be punishable by le"imprisonment or both under law " gnalure and Title of Company's Authorized Representative t..lJ. ReQ.ulahny f.JFfC./rf IfACJ1tJre/ 

Name of Company COm9RI'l'l LLG 13. Phone Number 
\ 

\ 

MICROst. .'. FLO 

lHEl'li.17!lEAL1llANDI'IlJrKmi COMPANY 

June 30, 2006 

Document Pr essing Desk (DCI/SRRD) 

Ms. Kar ones, Chemical Review Manager 

Pro uct Reregistration Branch 

Special Review and Reregistration Division - 7504P 

Office of Pesticide Programs 

U.S. Environmental Protection Agency 

One Potomac Yard (South Building) 

2777 S. Crystal Drive 

Arlington, VA 22202 

Dear Ms. Jones 

Subject: Thidiazuron-Diuron EC 

EPA Reg. No. 51036-429 

Data Call-In 8-Month Response 

Please find enclosed Micro Flo's 8-Month Response to the Product Specific Data 

Call-In for products containing the active ingredient diuron. The following 

materials are included in this submission: 

1.) Application for Registration 

2.) Data Matrix - Agency and Public Copies 

3.) Requirements Status and Registrant's Response - REVISED 

4.) Data Waiver Request 

5.) Five (5) copies of Draft labeling 

One Highlighted Copy and Four (4) Clean Copies 

RO Box 772099 • Memphis, TN 38117-2099 • Office: 901-432-5000 .. Fox: 901-432-5100 

488773-00 

65
Ms. Karen Jones 

Thidiazuron-Diuron EC 

June 30, 2006 

page 2 

Also submitted in support of this application are three copies of the following 

data, which are enclosed: 

1.) Physical Properties of Thidiazuron-Diuron EC, EPA OPPTS Guideline 

Reference Number 830.6302 and 830.6304, 9 pages 

Laboratory Project ID: MI-0601 MRID No. 46877301 

2.) Storage Stability of Thidiazuron-Diuron EC (C) with Corrosion 

Characterisiics, EPA OPPTS Guideline Reference Number 830.6317 and 

830.6320, 10 pages 

Laboratory Project ID: MI-0406 MRID No. 46677302 

3.) Thidiazuron-Diuron EC: Acute Oral Toxicity Up and Down Procedure in 

Rats, EPA OPPTS Guideline Reference No. 870.1100 (2002), 14 pages. 

Laboratory Study No. 19086 MRID No. 46877303 

4.) Thidiazuron-Diuron EC: Acute Dermal ToxiCity Study in Rats - Limit Test, 

EPA OPPTS Guideline Reference No. 870.1200 (1998), 14 pages 

Laboratory Study No. 19087 MRID No. 46877304 

5.) Thidiazuron-Diuron EC: Acute Inhalation Toxicity Study in Rats-LCso, 

EPA OPPTS Guideline Reference No. 870.1300 (1998), 30 pages 

Laboratory Study No. 19088 MRID No. 48877305 

6.) Thidiazuron-Diuron EC: Primary Eye Irritation Study in Rabbits, EPA 

Guideline Reference No. 870.2400 (1998),17 pages 

Laboratory Study No. 19089 MRID No. 46877306 

7.) Thidiazuron-Diuron EC: Primary Skin Irritation Study in Rabb·'{s, E"A 

Guideline Reference 870.2500 (1998), 15 pages 

Laboratory Study No. 19090 MRID No. 4687730_7 __ 

66
Ms. Karen Jones 

Thidiazuron-Diuron EC 

June 30, 2006 

page 3 

8.) Thidiazuron-Diuron EC: Dermal Sensitization Study in Guinea Pigs 

(Beuhler), EPA Guideline Reference No. 870.2600 (2003), 22 pages 

Laboratory Study No. 19091 MRID No. _4_68_7_73_0_8 __ 

If you have any questions with respect to this submission please do not hesitate 

to contact the undersigned at 901-432-5118. 

Sincerely, 

~~Lu~~ BiliWashbum 

Regulatory Affairs Manager 

67 

P

a

g

e
Page 68 - *Confidential Statements of Formula may be entitled to con
DATA PACKAGE BEAN SHEET 

Date: 06·Feb·2007 

Page t of 3 

* * * Registration Information * * * 

Registration: PDCI-03SS05-24653 

DP #: (336474) 

Short Name: ~i~_r_~I1 __ ~I:l<?LL!.2'~?~Q~t_~ __ . __ ~ _____________ ~_.____ ___ _____________ _ ____ " _________ _ 

Company: 51036 -BASF SPARKS llC 

Risk Manager: AM 81 - Unda - Propst - (703) 308-8165 Room# PYt S-9641 

Risk Manager Reviewer: _______________________ _ 

Type of Data Call in: CP~m~d~"'~t~S~p~"~if~i''_ ____ _ 

Ingredients: 035505, Dimon 

Guidelines: oS~"=pa~g~'~3'_ ________________________ _ 

* * * Data Package Information * * * 

Expedite: 0 Yes. No Date Sent: 06-Feb-2007 Due Back: ____ _ 

DP Ingredient: 035505, Diuron 

DP Title: Review acute lox data 

CSF Included: 0 Yes. No label Included: () Yes. No Parent DP #: 

Assigned To Da1e In Date Out 

Organization: ,S~R~R~D~/~P~R~B'_ _____ _ last Possible Science Due Date: 

Team Name: __________ _ Science Due Date: 

Reviewer Name: __________ _ Sub Data Package Due Date: 

Contractor Name: __________ _ 

* * * Studies Sent for Review * * * 

Printed on Page 2 

* * * Additional Data Package for this Decision * * * 

No Additional Data Packages 

* * * Data Package Instructions * * * 

Review acute tox data 66330-33 (formerly 51036-429) 

69
, Page 2 

DP#-: (336474) ••• Studies Sen110r Review'" Decision#-: (0) 

Moore, G. (2006) Acute Oral Toxicity Up '~:lo~'~~~;';~:~'3~"'~~:~~~;h" Thidiazuron-Diuron EC. Project Number: . study 

prepared by Product Satety Laboratories. 14 p. 

46877304 Moore, G. (2006) Acute Dermal Toxicity Study in Rats - Limit Test: Thidiazuron-Diuron 870. t200lAcute dermal10xicity 

EC. Project Number: 19087, P322. Unpublished study prepared by Product Safety 

Laboratories. 14 p. 

46877305 Moore, G. (2006) Acute Inhalation Toxicity Study in Rats - LCSO: Thidiazuron-Diuron 870.1300fAcute inhalation toxicity 

EC. Project Number: 19088, P330. Unpublished study prepared by Product Safety 

Laboratories. 30 p. 

46877306 Moore, G. (2006) Primary Eye Irritation Study in Rabbits: Thidiazuron-Diuron EC. 870.2400iAcute eye irritation 

Project Number: 19089, P324. Unpublished study prepared by Product Safety 

Labora1ories. 17 p. '< 

46877307 Moore, G. (2006) Primary Skin Irritation Study in Rabbits: Thidiazuron·Diuron EC. 870.2S00lAcute dermal irritation 

Project Number: 19090, P326. Unpublished study prepared by Product Safety 

Laboratories. 15 p. 

46877308 Moore, G. (2006) Dermal Sensitization Study in Guinea Pigs (Buehler Method): 870.2600fSkin sensitization 

Thidiazuron-Diuron EC. Project Number: 19091, P328. Unpublished study prepared by 

Product Safety Laboratories. 22 p. 

70
Ptease read Instruciions on reverse befOffi npleting form. Form Approved, OMB No. 2070-0060, Approval 

ex ires 05-31-98 

- EPA United States 0 Registration opp Identifier Number 

0 Environmental Protection Agency 0 Amendment 

Washington, DC 20460 0 Other: 

Application for Pesticide - Section I 

1. Company/Product Number 2. EPA Product Manager 3. Proposed Classification 

66330-333 J. MILLER 

4. CompanY/PlOduct (Name) PM. ONone o Restricted 

THIDIAZURON-DiURON EC 23 

5. Name and Address of Applicant (tnclude ZIP Code) 6. Expedited Review. In accordance with FIFRA Section 3{c){3) 

Arysta LifeScience North America Corporation 

(b){l), my product is similar or identical in composition and labeling 

to: 

15401 Weston Parkway, Suite 150 EPA Reg. No. 

Cary, NC 27513 

Product Name 

D Check if this is a new address 

Section -II 

o Amendment - Explain below. D Final printed labels in lesponse to Agency lelter daled 

(Sl Resubmission in response to Agency letter dated j/25/07 o "Me Too" Application 

o Notification - Explain below. o Other - Explain below 

Explanation: USe additional page(s) if necessary. (For Section I and Section 11.) 

Resubmission in response to Agency letter dated 1/25/07. Submission of Confidential Statements of Formula, 

revised labeling to reflect change in ownership and a revised Formulator's Exemption Statement for the active 

ingredient Diuron. 

Section -III 

1. Material This Product Will Be Packa ed In: 

Child-Resistant Packaging Unit Packaging Water Soluble Packaging 2. Type of Containel 

DYes' DYes o Yes o Metal 

IS] No IS] No IS] No (Sl PlasUc 

If "Yes" No. per If "Yes" No. per o Glass 

*Certification must Unit Packaging wgt. container Package wgt. container o Paper 

be submitted o Othel (Specify) 

3. localion ot Net Contents Information 4. Size(s) Retail Container 5. location of label Directions 

(Sllabel D Container (Sl On label 

2.5 gal, 15 gal, 30 gal, 55 gal and bulk o On labeling accompanying product 

6. Manner in Which label is Affixed to Producl o lilhoglaph o Other 

[8] Paper glued 

o Slenciled 

Section -IV 

1. Contact Poinl (Comp/ete items directly below for identification of individual to be contacted, if necessary, to process this application) 

Name Title ,! Telephone NC;(Include Area 

BILL WASHBURN REGULATORY AFFAIRS MANAGER :\)'~0lje) } ,> 

: .. : 901-432-5118 

Certification .. , , , 6. Date Application . I certify that the statements I have made on this form and all attachmenls thereto are true, accurate and complete. I ' Repiliv~d 

acknowledge that any knowingly false or misleading stalement may be punishable by fine or imprisonment or both ' J~t~lnped) 

under applicable law. .~ , 

2'\6~ L:o-o~ 3. Tille ,'" " . REGULATORY AFFAIRS MANAGER .~_~ 4' 

4. Typed Name 5. Date ., . . BILL WASHBURN February 6, 2007 ., , 

. . . - .. . EPA Form 8570 1 (Rev. 8 -94) Previous editions are obsolete White EPA File Copy (onglnal) Yellow Applicant Copt 

71
F orm approve d . OMB NO 2070 -0060 A pprova IE xplres 1 -3(}'93 

United States Environmental Protection Agency 

ft Washington, D.C. 20460 

-- o EPA Formulator's Exemption Statement , 

-

(40 CFR 152_85) - . ; 

Applican1's Name and Address EPA File SymbolfRegistration Number 

Arysta LifeScience North America Corporation 66330-333 

15401 Weston parkway, Suite 150 " .. -.~---

Product Name 

Cary, NC 27513 THIDIAZURON-DiURON EC 

Date of Confidential Sialement of Fonnu,a'{EPA Form 8570-4) 

02105107 

As an authorized representative of the applicant for registration of the product identified above, I here certify that: 

(1) This product contains the following active ingredient(s): Thidiazuron and Diuron 

(2) Of these, each active ingredient listed in paragraph (4) is present solely as Ihe result of the use of that active 

ingredient in the manufacturing, formulation or repackaging of another product which contains that active 

ingredient, which is registered under FIFRA Section 3, is purchased by us from another producer, and is labeled 

for alleast each use for which my product is proposed 10 be labeled. 

(3) Indicate by checking (A) or (8) below which paragraph applies: 

o (A) An accurate Confidential Statement of Formula (EPA Form 8570-4) for Ihe above identified product is 

attached to this statement. That formula slatement indicates, by company name, registralion number, and 

product name, the source of the active ingredient(s) listed in paragraph (1). 

OR 

[gJ (8) The Confidential Statement of Formula (eSF) (EPA Form 8570-4) referenced above and on file wilh 

the EPA is complete, current, and accurate and contains the informalion required on the current CSF. 

(4) The following active ingredients in this product qualify for the formulator's exemption. 

Source 

Active Ingredient Product Name Registration Number 

Diuron 

Sb:, WC<ilLJhLc~ Name and Title D,te 

Bill Washburn 02105107 

Regulatory Affairs Manager 

EPA Form 8570-27 (Rev. 7·91) White - EPA copy Yellow· Applicant copy 

72

*Product ingredient source information may be entitled to confidential treatment*
Certified Mail Provides: 

• A mailing receipt (cSJlMulj) ~om: aunr 'oosc w,~ Sd 

• A unique identifier for your mailpiece 

• A record of delivery kepI by the Postal SeNiee fortwa years 

/mp'ortant Reminders: • Certified Mall may ONLY be combined w1\h First-Class Mailo or Priority Mai"'ll. 

• Certffied MaillS nol available for any class of Inlernational mail. 

c NO INSURANCE COVERAGE IS PROVIOED with Certified Mall. For 

valuables, please consider Insured or Registered Mall. 

a For an additional fee, a Raturn Reoaipfmay be requested fo provide proof of 

delivery. To obtain Return Receipt OOIVIC€!, pfease complete and attach a Return 

Reoeipl (PS FOffi1 3811) fo the articla and add applicable pas/age fo cover Ihe 

fee, Endorse mailpiece 'Holum Receipt Requested". To receive a fee waiver for a dvplic!lle relurn receipt, a USPS® postmark on your Certified Mail racelplls reqUired. 

• For an addllional fee, delivery may be restricted to file addressee or addressee's authorized agenf. Advise fhe clerk or mark the mallplece with the 

endorsement 'RestricfedDelivery'. 

• II a poslmark on the Certified Mail receipt is desired, please present fhe article al the post oHice for postmarking. If a postmark on the Certilied Mall 

receipl is not needed. detach and allix label with postage and mall. 

IMPORTANT: Salle Illis receipt and present it wilen making an inquiry. Internet access tn delivery intormalion is nol avaiiable on mali 

addtessed to APOs and FPOs. 

73
74
Micro Flo Company LLC 

P.O. Box 772099 

Memphis, TN 38117 

PRODUCT NAME: Thidiazuron-Diuron EC 

EPA File Symbol: 51036-429 

DATA WAIVER REQUEST 

OPPTS Guideline 830.6319 

The purpose of this test is to obtain information and determine the miscibility for a 

product. This test is intended to determine whether a pesticide solution is 

suitable for application after dilution with oil or other nonpolar solvents, where 

applicable, instead of water. 

Thidiazuron-Diuron EC is made up with emulsifiers that work only when 

diluted in water. The label for this product is written to limit the application of this 

product in water and/or tank mixes with water. 

For this reason we are requesting a waiver of this data requirement. 

Reference: 

Product Properties Test Guidelines: OPPTS 830.1000, Background for 

Product Properties Test Guidelines; EPA 712-C-96-310, August 1996 

MFC Waiver 51036·432 (830.6319) 1 

75

*Inert ingredient information may be entitled to confidential treatment*
Micro Flo Company LLC 

P.O. Box 772099 

Memphis, TN 38117 

PRODUCT NAME: Thidiazuron-Diuron EC 

EPA File Symbol: 51036-429 

DATA WAIVER REQUEST 

OPPTS Guideline 830.6319 

The purpose of this test is to obtain information and determine the miscibility for a 

product. This test is intended to determine whether a pesticide solution is 

suitable for application after dilution with oil or other nonpolar solvents, where 

applicable, instead of water. 

Thidiazuron-Diuron EC is made up with emulsifiers that work only when 

diluted in water. The label for this product is written to limit the application of this 

product in water and/or tank mixes with water. 

For this reason we are requesting a waiver of this data requirement 

Reference: 

Product Properties Test Guidelines: OPPTS 830.1000, Background for 

Product Properties Test Guidelines; EPA 712-C-96-310, August 1996 

MFC Waiver 51036·432 (830.6319) 1 

76

*Inert ingredient information may be entitled to confidential treatment*
Micro Flo Company LLC 

P.O. Box 772099 

Memphis, TN 38117 

PRODUCT NAME: Thidiazuron-Diuron EC 

EPA File Symbol: 51036-429 

DATA WAIVER REQUEST 

OPPTS Guideline 830.6321 

The purpose of this test is to determine the potential for hazard when the 

pesticide product is used on or in the vicinity of electrical equipment and 

electrical conduits. Data is required when the end-use product is a 

nonconductant liquid and is to be used around electrical equipment. 

Thidiazuron-Diuron EC is formulated with nonconductant solvents, but it is 

not designed to be used around electrical equipment or electrical conduits. 

Thidiazuron-Diuron EC is a cotton harvest aide and is not labeled for use around 

electrical equipment of electrical conduits. 

For this reason we are requesting a waiver of this data requirement. 

Reference: 

Product Properties Test Guidelines: OPPTS 830.1000, Background for 

Product Properties Test Guidelines; EPA 712-C-96-310, August 1996 

MFC Waiver 51 036-432 (830.6321) 1 

77

*Inert ingredient information may be entitled to confidential treatment*
Micro Flo Company LLC 

P.O. Box 772099 

Memphis, TN 38117 

PRODUCT NAME: Thidiazuron-Diuron EC 

EPA File Symbol: 51036-429 

DATA WAIVER REQUEST 

OPPTS Guideline 830.6321 

The purpose of this test is to determine the potential for hazard when the 

pesticide product is used on or in the vicinity of electrical equipment and 

electrical conduits. Data is required when the end-use product is a 

nonconductant liquid and is to be used around electrical equipment. 

Thidiazuron-Diuron EC is formutated with nonconductant solvents, but it is 

not designed to be used around electrical equipment or electrical conduits. 

Thidiazuron-Diuron EC is a cotton harvest aide and is not labeled for use around 

electrical equipment of electrical conduits. 

For this reason we are requesting a waiver of this data requirement. 

Reference: 

Product Properties Test Guidelines: OPPTS 830.1000, Background for 

Product Properties Test Guidelines; EPA 712-C-96-310, August 1996 

MFC Waiver 51036·432 (830.6321) 1 

78

*Inert ingredient information may be entitled to confidential treatment*
Date: 0:;;>-[ 111 (J ~ 

OPPIN 

PDCI RESPONSES 

IN PROCESSING FORM 

CASE NUMBER: 

PRODUCT NUMBER(s): 

Circle appropriate submission/response code: 

SUBMISSION TYPE: ~ay Re~ 1 tooth Response 

RESPONSE CODE: 

(For 90-day responses) 

(For 8 month responses) 

10 M Incomplete Response 

50 - Voluntary Cancellation 

94 - NOITS 

10 M Incomplete Response 

11 - Data Deficiency 

50 M Voluntary Cancellation 

94 - NOITS 

79
MICRO "'FLO 

THEI'IANrlliAmiAhul'ImB:i1JN COMPANY 

February 6, 2006 

Ms. Karen Jones, Chemical Review Manager 

Product Reregistration Branch 

Special Review and Reregistration Branch 7508W 

Office of Pesticide Programs 

Crystal Mall 2, Room 266A 

180 I South Bell Street 

Arlington, VA 22202 

Subject: Thidiazuron-Diuron E. C 

EPA Reg. No. 51036-429 

Diuron Data Call-In - 90-Day Response 

Dear Ms. Jones: 

Per the requirements of the Diuron Data Call-In dated October 28,2005, please find the 

fonowing documents enclosed in support of the subject product: 

• Data CaIl-In Response 

• Requirement's Status and Registrant's Response 

• Data Waiver Request - OPPTS Guideline 830.6319 

• Data Waiver Request - OPPTS Guideline 830.6321 

The product specific data that has been cited in the Requirement's Status and Registrant's 

and revised labeling response wiII be submitted in the time frame allowed in the Data 

CaIl-In. Should you have any questions in regards to this submission, please do not 

hesitate to contact me at 901-432-5118 or bilI.washburn@microflocompany.com. 

Sincerely, 

/) 

,j~~rJ/j~ Bill Washburn 

Regulatory Affairs Manager 

~t . 

:t/1o/bt 

-"------P.cxtrox 772099 It Memphis, TN 38117-2099 It Office: 901-432-5000 It Fox: 901-432~q ~,OO 

" > > , , 

, " , . " , , , , , , 

"" , , " , " 

80
United States Environmental Protection 

Agency Washington, D.C. 20460 

DATA CALL-IN RESPONSE 

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. 

Use additional sheet(s) if necessary. 

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI an

MICRO-FLO COMPANY LLC 0046 Diuron 28-0ct-2005 

530 OAK COURT DRIVE Chemical # and Name 035505 PRODUCT SPECIFIC 

MEMPHIS, TN 38117 Diuron 10# PDCI-035505-2

4. EPA 5. I wish to 6. Generic Data 7. Product Specific Data 

Product cancel this Registration product regis- 6a. I am claiming a Generic 6b. I agree to satisfy Generic 7a. My product is an MUP and 

tration Yolun- Data Exemption because I Data requiremenls as indicated I agree to satisfy the MUP 

tarily obtain the active ingredient on the attached form entitled requirements on the attached 

from the source EPA regis- "Requirements Status and form entitled "ReqUirements 

tration number listed below. Registrant's Response." Status and Registrant's 

Response." 

51036-429 NA NA 

. 

, , , , 

, , . 

, 

8. Certification I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any 9. Date 

1/2

knowingly false may be punishable bYh !mprisonment or both under applicable law. , Signature and Ttlle:of S;OLtlpaf1:l's Authorized Representative Uf £ hl':J fJf!k/lf 5 IlAcnoq ef 

fO. Name of _ •• I'r\lclZO 'LO CtlMPAN'i LLe 11. Phone Number 
United States Environmental Protection 

Agency Washington, D.C. 20460 

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE 

INSTRUCTIONS: Please type or print in ink, Please read carefully the attached ins!ructions and supply the information requested on this 10rm, 

Use additional shee!(s) if necessary. 

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and 

MICRO-FLO COMPANY LLC 0046 Diuron 28-0ct-2005 

530 OAK COURT DRIVE PRODUCT SPECIFIC 

MEMPHIS, TN 38117 10 # PDCI-035505-24

EPA Reg. No. 51036-429 

4. Guideline 5. Study Title p 6. Use 7. Test 

R Progress Requirement 0 Pattern Substance 

Number T Reports 

0 

C 

0 

L 1 2 3 

eCQgY!<i Qilt" B!l!gYilll:rn!l!!ltli (CQ[]y!U!lis;![!a! 

Chemica!) 

830.1550 Product Idenlity and composilion (28) A, B, C, 0, E, F, G, H, I, TGAI/MP/EP 

J, K, L, M, N, 0 

830.1600 Description of materials used to produce the product (29) A, B, C, 0, E, F, G, H, I, TGAI/MP/EP 

J, K, L, M, N, 0 

830.1620 Description of production process (30) A, B, C, 0, E, F, G, H, I, TGAI 

J, K, L, M, N, 0 

830.1650 Description of formulation process (31) A. B, C, 0, E, F, G, H, I, MP/EP 

J, K, L, M, N, 0 

830.1670 Discussion of formation of (32) A, B,C, 0, E,F,G, H, I, TGAI/MP/EP 

J, K, L, M, N, 0 

830.1700 Preliminary analysis (33,34,35) A, B, C, 0, E, F, G, H, I, TGAI 

J, K, L, M, N, 0 

830.1750 Certified limits (36 ,37) A,B, C, 0, E, F,G,H, I, TGAI/MP/EP 

J, K, L, M, N, 0 

830.1800 Enforcement analyUcal method (38) A, B, C, 0, E, F, G, H, I. TGAIIMP/EP 

J, K, L, M, N, 0 

830.6302 Color (13) A, B, C, 0, E, F, G, H, I, TGAI/MP/EP 

: lPhysical : 

J, K, L, M, N, 0 

830.6203:' (16) A, B, C, 0, E, F, G, H, I, TGAI/MP/EP 

. . 

c _ 

J, K, L, M, N, 0 - - -

10. Certification Gertify': at<ihe sta!ements made on this form and aU attachments are true, a cur te, nd mplete. I acknowledge that any 11. Date 

knowingly false may be punishable by le"imprisonment or both under law '/fA 1/2

Signature and Title Representative th ReQ"falvlL{ f}(1c,tf.( CJ1t:9t>/ 

12. Name of Company rLO tom DAN'! LLC, 13. Phone Number 
United States Environmental Protection 

Agency Washington, D.C. 20460 

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE 

INSTRUCTIONS: Please type or print in ink. Please read carefully the allached instructions and suppty the information requested on this form. 

Use additional sheel(s) if necessary. 

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI an

MICRO-FLO COMPANY llC 0046 Diuron 28-0ct-2005 

530 OAK COURT DRIVE PRODUCT SPECIFIC 

MEMPHIS, TN 38117 10 # PDCI-035505-24

EPA Reg. No. 51036-429 

4. Guideline 5. Study Tille p 6. Use 7. Test 

R Progress Requirement 0 Reports Pallern Substance 

Number T 

0 

C 

0 

L 1 2 3 

830.6304}(, Odor (17) A, S, C, 0, E, F, G, H, I, TGAIIMP/EP 

J, K, l, M, N, 0 

830.6313 Stability to sunlight, normal and elevated (5.6) A, S, C, 0, E, F, G, H, I, TGAI 

temperatures, metals, and metal ions J, K, l, M, N, 0 

830.6314 Oxidizing or reducing action (7) A, S, C, 0, E, F, G, H, I, MP/EP 

J, K, l, M, N, 0 

830.6315 Flammability (8) A, S, C, 0, E, F, G, H, I, MP/EP 

J, K, 

l, M, N, 0 

830.6316 Explodabilily (9) A, S, C, 0, E, F, G, H, I, 

J, K, l, M, N, 0 

MP/EP 

830.6317 ' Storage stability of product (10) A, S, C, 0, E, F, G, H, I, MP/EP 

J, K, l, M, N, 0 

830.6319 ' Miscibility (12) A, S, C, 0, E, F, G, H, I, MP/EP 

J,K,l,M,N,O 

830.6320' Corrosion characteristics (14) A, S, C, 0, E, F, G, H, I, MP/EP 

J, K, l, M, N, 0 

830.6321\ Oielectric breakdown voltage (15) A, S, C, 0, E, F, G, H, I, 

J, K, l, M, N, 0 

MP/EP 

830.7000 pH of water solutions or suspensions (3,4) A, S, C, 0, E, F, G, H, I, TGAI/MP/EP 

: hVtyisibJe 

J, K, l, M, N, 0 

830.7C50: A, S, C, D, E, F, G, H, I, TGAI/PAI 

J, K, l, M, N, 0 

" " " " " " "" " "" " " "" I v v _ 130 i . tnitial to indicate a'" io-information on this page Date (full text of certification is on page one). 
United States Environmental Protection 

Agency Washington, D.C. 20460 

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE 

INSTRUCTtONS; Ptease type or print in ink. Ptease read carefutty the attached instructions and suppty the information requested on this form. 

Use additionat sheet(s) if necessary. 

1. Company Name and Address 2. Case # and Name 3. Date and Type of OCt and 

COMPANY LlC 0046 Diuron 28-0ct-2005 

530 OAK COURT DRIVE PRODUCT SPECIFIC 

MEMPHIS, TN 38117 10 # PDCt·035505-24

EPA Reg. No. 51036-429 

4. Guidetine 5. Study Tilte p 6. Use 7. Test 

R Progress Requirement 0 Reports Pattern Substance 

Number T 

0 

C 

0 

l 1 2 3 

830.7100 Viscosity (11 ) A, B, C, 0, E, F, G, H, t, 

J, K, l, M, N, 0 

MP/EP 

830,7200 Metting point/metting range (18,19) A, B, C, 0, E, F, G, H, t, TGAI 

J, K, L, M, N, 0 

830.7220 Boiting point/boiting range (20.21) A, B, C, 0, E, F, G, H, I, TGAI 

J, K, L, M, N, 0 

830.7300 Densitylretative density (22,23) A, B, C, 0, E, F, G, H, I, TGAI/MP/EP 

J, K, l, M, N, 0 

830.7370 Dissociation constant in water (39,40) A, B, C, 0, E, F, G, H, I, 

J, K, l, M, N, 0 

TGAI or PAt 

830.7550 Partition coefficient (n-octanot/water), shake flask (1) A, B, C, 0, E, F, G, H, I, TGAIIPAI 

method J, K, L, M, N, 0 

830.7570 Partition coefficient (n-octanotfwater), estimation by (2) A, B, C, 0, E, F, G, H, I, TGAt/PAI 

tiquid chromatography J, K, l, M, N, 0 

830.7840 Water sotubitity: Cotumn etution method, shake flask (24) A, B, C, 0, E, F, G, H, I, TGAI or PAl 

method J, K, l, M, N, 0 

830.7860 Water sotubitity, generator cotumn method (25) A, B, C, 0, E, F, G, H, I, TGAI or PAl 

J, K, l, M, N, 0 

830.7950 Vapor pressure (26,27) A, B, C, 0, E, F, G, H, I, TGAI or PAl 

RequiOlments (Conventionat Chemjcall 

J, K, L, M, N, 0 

. 

. 

.. 

, , , . 

" " .. " . , ". 

InWallo indicate ac information on this page 80.; Date I / 

(futllexl of certification is on page one). 
United States Environmental Protection 

Agency Washington, D.C. 20460 

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE 

INSTRUCTIONS: Please type or prinl in ink. Please read carefully the attached instructions and supply1he information requested on this form. 

Use additional sheet(s) if necessary. 

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI an

MICRO-FLO COMPANY LLC 0046 Diuron 28-0ct-2005 

530 OAK COURT DRIVE PRODUCT SPECIFIC 

MEMPHIS, TN 38117 10 # PDCI-035505-24

EPA Reg. No. 51036-429 

4. Guideline p 5. Study TWe 6. Use 7. Test 

R Progress Requirement 0 Reports Pattern Substance 

Number T 

0 

C 0 

L 1 2 3 

870.1100 Acute Oral Toxicity (49) A. B, C, 0, E, F, G, H, I, TGAI,EP,dilute EP? 

J, K, L, M, N, 0 

870.1200 Acute dermal toxicity (41 ,42) A, B, C, 0, E, F, G, H, I, TGAI,EP,dilute EP? 

J, K, L, M, N, 0 

870.1300 Acute inhalation toxicity (48) A, B, C, 0, E, F, G, H, I, TGAI & EP 

J, K, L, M, N, 0 

870.2400 Acute eye irritation (43) A, B, C, 0, E, F, G, H, I, 

J, K, L, M, N, 0 

TGAI & EP 

870.2500 Acute dermal irritation (44,45) A, B, C, 0, E, F, G, H, I, TGAI & EP 

J, K, L, M, N, 0 

870.2600 Skin sensitization (46,47) A, B, C, 0, E, F, G, H, I, TGAI & EP 

J, K, L, M, N, 0 

Initial to indicate certification as to information on this page 6w Date i I z L

(full text of certification is on page one). 
- -- ... -----_ 

• 

, 

SpHldl&JI\I------ _________ .. ___ .. 

I, 

) 

86
DIT )N PRODUCT SPECIFIC DATA CALL-Il 

Please read instruC/ions on reverse before comp/elill:, ,o'rm Form Approved , OMS No 2070·0060 Approval 

; 

- EPA United States o Registration opp Identifier Number 

0 Environmental Protection Agency o Amendment 

i ,DC 20460 other: 

Application for Pesticide - Section I 

1. C I 3. I , " 

4. I IIRn~ EC ;~. [3J None o Reslricled 

I 

5. ,ot " I (tod,d, ZIP Cod,; 6. i In , with FIFRA 

MICRO FLO COMPANY LLC 

{b}{I}, my product is similar or identical in composition and labeling 

to: 

P.O. BOX 772099 EPA Reg. No. 

MEMPHIS, TN 38117 

Product Name 

o Check if this is a new address 

Section -II 

:= Amendment - Explain below. Final printed labels in response 10 Agency leller daled 

Resubmission in response to Agency leiler dated __ ! "Me Too" Application F " - E",,;o b,'ow. Olh" - E"I,;o b,'ow 

'II. Use additional I if necessary. (For i I and , II.) 

Submission of 8-Month Response in support of Diuron Product Specific Data Cali-In dated October 28, 2005. 

Section ~ III 

I ill : 

i ; ~II ~I" Sol,bl, ~Type< 

DYes' R ~~s yeo Melal 

o No : No Plaslic 

~~~e;~ No. pee ' ,,,. NO. pee Glass 

*Ceriification must , wgl. I wgt , Paper 

be submitted i 

i 1011 " 4. 81"", K'~II' II 1 oIL", 

o label o Container =j On Label 

: 001 " i tPcod,ot 

6. Manner in Which Label is Affixed 10 Producl ; i ~'P';9i",d 

o Olher 

Section ~ IV 

1. Coo~ot Po;ol (e I , be< " 10 pro"'" . 

N~7~L WASHBURN I TIII~EGULATORY AFFAIRS MANAGER 

. I "ce, Code) :"" " , ' 8 

6. ".ale i i 

I Ihe slalemenls I have made on Ihis form and all allachments Iherelo are true, accurale and complele.' I' , • ' Received 

thai any knowlngly false or misleading slalemenl may be punishable by fine or imprisonmenl or both ~Stal7lped} 

" law. ' p " " 2. I 

~ET~'~LATORY AFFAIRS MANAGER 

, 

C-z,: ,L =L 0, ,;., , , ,J, , 

~1~r~~;';;'BURN 5. "at, 

June 30, 2006 '" , , 

" , 

EPA Form 8570·1 (Rev. 8-94) oc. I Whlt,-, i i., .'1 Y,lIow-, " 

87
Uuited States Envirorunental Protection 

Agency Washington, D_C 20460 

" " STATUS AND REGISTRANT'S RESPONSE 

" 

NSTRUCTIONS: Please type or 9rint in ink. reat c<>:re(ullr the attached instructions and supply the information requested on this form. 

Jse additional sheet(s) if necessaty. " " " 

Company Name and Address 2. Case # and Name 3. Date and Type of DCI and 

" " 

MICRO-FLO COMPANy LLC ' " 0046 Diuron 28-0ct-2005 ' " .. , , , 

" 530 OAK COURT DRIVE .... , " PRODUCT SPECIFIC 

MEMPHIS, TN 38117 ID # PDCI-035505-24

EPA Reg. No. 51036-429 

I. Guideline 5. Study Title p 6. Use 7. Test 

R Progress 

0 Reports Pattern Substance 

T 

0 

C 

0 

L 1 2 3 

30.6304', Odor (17) A, 8, C, D, E, F, G, H, I, TGAI/MP/EP 

J, K, L, M, N, 0 

30.6313 Stability to sunlight, normal and elevated (5,6) A, B, C, D, E, F, G, H, I, TGAI 

temperatures, metals, and metat ions J,K,L,M,N,O 

30.6314 Oxidizing or reducing action (7) A, B, C, D, E, F, G, H, I, MP/EP 

J, K, L, M, N, 0 

30.6315 Flammability (8) A,B,C,D,E,F,G,H,I, MP/EP 

J, K, L, M, N, 0 

30.6316 Explodability (9) A, B, C, D, E, F,G, H, I, MP/EP 

J, K, L, M, N, 0 

30.6317 Storage slability of product (10) A, B, C, D, E, F, G, H, I, MP/EP 

J, K, l, M, N, 0 

30.6319 Miscibility (12) A, B, C, D, E, F, G, H, I, MP/EP 

J, K, L, M, N, 0 

30.6320 Corrosion characteristics (14) A, B, C, D, E, F, G, H, I, MP/EP 

J, K, L, M, N, 0 

30,6321 Dielectric breakdown vdtage (15) A, B, C, D, E, F, G, H, I, MP/EP 

J, K, L, M, N, 0 

30.7000 pH of water solutions or suspensions (3,4) A, B, C, D, E, F, G, H, I, 

J, K, L, M, N, 0 

TGAI/MP/EP 

10.7050 UVIVisible absorption A, B, C, D, E, F, G, H, I, TGAI/PAI 

J, K, L, M, N, 0 

itial to indicate certification as to information on this page OG Date )11 text of certification is on page one). (" J 3D

-_ ... _ ... 
United States Environmental Protection 

Agency Washington, D.C. 20460 

STATUS AND REGISTRANT'S RESPONSE 

>JSTRUCTIONS: Please type or:):Jrint in ink. Plea!te rea0 c{!re!ull1:' the attached instructions and supply the information requested on this form. 

Ise additional sheeUs) If necessary. 

Company Name and Address " 2. Case # and Name 3. Date and Type of DCI and 

, , 

MICRO-FLO COMPANY LLC . , , -

,. 

0046 Diuron 28-0ct-2005 

530 OAK COURT DRIVE PRODUCT SPECIFIC 

MEMPHIS, TN 38117 

EPA Reg. No. 51036-429 ID # PDCI-035505-246

Guideline 5. Study Title p 6. Use 7, Test 

R Progress 

0 Reports Pattern Substance 

tumber T 

0 

C 

0 

L 1 2 3 

30.7100 Viscosity (11 ) A, B, C, D, E, F, G, H, I, 

J, K, L, M, N, 0 

MP/EP 

30.7200 Melling point/meltin9 range (18,19) A, B, C, D, E, F, G, H, I, TGAI 

J, K, L, M, N, 0 

30.7220 Boiling point/boiling range (20.21) A, B, C, D, E, F, G, H, I, TGAI 

J, K, L, M, N, 0 

10.7300 Density/relative density (22,23) A, B. C, D, E, F, G, H, I, TGAI/MP/EP 

J, K, L, M, N, 0 

30.7370 Dissociation constant in water (39.40) A, B, C, D, E, F, G, H, I, TGAI or PAl 

J, K, L, M, N, 0 

30.7550 Partition coefficient (n-octanot/water). shake flask (1 ) A, B, C, D, E, F, G, H, I, TGAI/PAI 

method J,K,L,M,N,O 

30.7570 Partition coefficient (n-octanolfwater), estimation by (2) A, B, C, D, E, F, G, H, I. TGAI/PAI 

liquid chromatography J, K, L. M, N, 0 

10.7840 Water solubility; Column elution method, shake flask (24) A, B, C, D, E, F, G, H, I, TGAI or PAl 

method J, K, L, M, N, 0 

10.7860 Water solubility, generator column melhod (25) A, B, C, D, E, F, G, H, I, TGAI or PAl 

J, K, L, M. N, 0 

10.7950 Vapor pressure (26,27) A, B, C, D, E, F, G, H, I, TGAI or PAl 

J, K, L, M, N, 0 

TQxicQIQgy: Data 

·tiallo indicate certification as to information on this page 6Cv Date of certification is on page one). 
United States Environmental Protection 

Agency Washington, D.C. 20460 

REQUIRE'V/!ll\!'i'S STATUS AND REGISTRANT'S RESPONSE 

NSTRUCTIONS: Please type or:print in ink. rea:! c:mJulty the attached instructions and supply the information requested on this form_ 

Jse additional sheet(s) if necessary. 

I Company Name and Address " " .. -- " " 2. Case # and Name 3. Date and Type of DCI and 

" . . 

MICRO-FLO COMPANY llC- " . - -. '. '. -- 0046 Diuron Z8-0ct-Z005 

. " 530 OAK COURT DRIVE " . PRODUCT SPECIFIC 

MEMPHIS, TN 38117 ID # PDCI-035505-24

EPA Reg. No. 51036--429 

I, Guideline 5. Study Title , 6. Use 7. Test 

R Progress 0 Reports Pattern Substance 

T 

0 

C 

0 

L 1 2 3 

70.1100 Acute Oral Toxicity (49) A, B, C, D, E, F, G, H, I, TGAI,EP,dilute EP? 

J, K, l, M, N, 0 

70.1200 Acute dermal toxicity (41, .42) A, B, C, D, E, F, G, H, I, TGAI,EP,dilute EP? 

J,K,l,M,N,O 

70.1300 Acute inhalation toxiCity (48) A, 8, C, D, E, F, G, H, I, TGAI & EP 

J, K, l, M, N, 0 

70,2400 Acute eye irritation (43) A, B, C, D, E, F, G, H, I, TGAI & EP 

J, K, l, M, N, 0 

70.2500 Acute dermal irritation (44 ,45) A,B,C,D,E,F,G,H,1. TGAI & EP 

J, K, l, M, N, 0 

70.2600 Skin sensitization (46,47) A, S, C, D, E, F, G, H, I, 

J, K, l, M, N, 0 

TGAI & EP 

itial to indicate certification as to information on this page DLD Date JII text of certification is on page one). 

----- ----- -"---
Micro Flo Company LLC 

P.O. Box 772099 

Memphis, TN 38117 

PRODUCT NAME: Thidiazuron-Diuron EC 

EPA File Symbol: 51036-429 

DATA WAIVER REQUEST 

OPPTS Guideline 830.6316 

PAGE 1 

The purpose of this test is to obtain information and determine the explodability 

for a product 

Thidiazuron-Diuron EC is made up with solvents. 

of the formulation. The 

remaining components are active ingredients and emulsifiers. 

The physical and chemical characteristics of the solvents are as follows: 

For this reason we are requesting a waiver of this data requirement. 

, 

" 

" 

" " , » " , 

. ;' ,Reference:" " )} 

, 

Produc(PNfperties Test Guidelines: OPPTS 830.1000, Background for 

'ProducI6'rdperties Test Guidelines; EPA 712-C-96-310, August 1996 

91

*Inert ingredient information may be entitled to confidential treatment*
THIDIAZURON-DIURON EC 

COTTON DEFOLIANT 

For Agricultural Use Only 

ACTIVE INGREDIENTS: Thidiazuron: N-phenyl-N'-1 ,2,3-thidiazol-5-ylurea* ............ ' ........... 12% 

Diuron: 3-(3,4-dichlorophenyl)-1, 1-dimethylurea*, .. ,." ...................................................... 6% 

OTHER INGREDIENTS: .......................................................................................... 82% 

TOTAL 100% 

Contains 1 lb. Thidiazuron per gallon and 0.5 lb. Diuron per gallon 

KEEP OUT OF REACH OF CHILDREN 

DANGER - PELIGRO 

5i usled no entiende la etiqueta, busque a alguien para que se la explique a usled en detalle. 

(If you do not understand this label, find someone to explain it to you in detail.) 

FIRST AID 

IF ON SKIN OR • Take off contaminated clothing. 

CLOTHING: • Rinse skin immediately with plenty of water for 15-20 minutes. 

• Call a Doison control center or doctor for treatment advice. 

IF IN EYES: • Hold eye open and rinse slowly and gently with water for 15-20 minutes. 

• Remove contact lenses, if present, after the firs! 5 minutes, then continue 

rinsing. 

• Call a poison control center or doctor for treatment advice. 

IF INHALED: • Move person to fresh air. 

• If person is nol breathing, call 911 or an ambulance, then give artificial 

respiration, preferably mouth-Io-mouth is possible. 

• Call a Doison control center or doctor for treatment advice. 

IF SWALLOWED: • Immediately call a poison control center or doctor for treatment advice. 

• Do not induce vomiting unless told to do so by a poison control center or 

doctor. 

• Have person sip a glass or water if able to swallow. 

• Do not Qive anything by mouth to an unconscious person. 

NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate the use of gastric 

lavage. 

HOT LINE NUMBER 

Have the product container or label with you when calling a poison control center or doctor 

or going for treatment. 

EMERGENCY NUMBERS: , " 

• Transportation or spill, call CHEMTREC 800-424-9300. 

Human and Animal health, 866-303-6952 ' , • , , , , 

,)' ' 

, , 

, SEE INSIDE (SIDE PANEL) FOR ADDITIONAL PRECAUTIONS AND USE DIREctiONS , ' . " " 

EPA Reg. No. 51036-429 

ADXXXXXX 

Manufactured by 

Micro Flo Company LLC 

P. O. Box 772099 

Memphis, TN 38117 

Filen~nJe: Thjdj~7.uron-Djuron EC (429·081705) (RED 062806) clean 

EPA Est. No. 510'3S'-G'A-001 , " NET CONTENTS': _'_' _' _--' " " 

Page 1 

, , ' > , 

92
PRECAUTIONARY STATEMENTS 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

DANGER 

Corrosive. Causes irreversible eye damage. Causes bums. Harmful if inhaled. Do not get in eyes, on 

skin, or on clothing. Avoid breathing dust or spray mist. Prolonged or frequently repeated skin-contact 

may cause aJlergic reactions in some individuals. 

PERSONAL PROTECTIVE EQUIPMENT 

Some materials that are chemical-resistant to this product are barrier laminate or butyl rubber gloves. If 

you want more options, follow the instructions for category C on an EPA chemical-resistance category 

selection chart. 

All pilots, flaggers, and groundboom applicators must wear: 

• Long-sleeved shirt and long pants and, 

• Shoes plus socks 

All mixers, loaders, other applicators, and other handlers must wear: 

• Long-sleeved shirt and long pants, 

• Shoes plus socks, 

• Chemical resistant gloves, such as barrier laminate or butyl rubber gloves 

• A NIOSH-approved dust/mist filtering respirator with any N2

, R, P or HE filter or an NIOSH-approved 

dust/mist filtering respirator with approval number prefix TC-21 C. 

• Chemical-resistant apron when mixing, loading, or cleaning equipment or spills 

Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables 

exist, use detergent and hot water. Keep and wash PPE separately from other laundry. 

ENGINEERING CONTROLS STATEMENT 

Pilots must use an enclosed cockpit that meets the requirements, listed in the Worker Protection 

Standard (WPS) for agricultural pesticides [40 CFR 170.240{d){6)]. 

Flaggers supporting aerial applications must use an enclosed cab that meets the definition in the Worker 

Protection Standard for Agricultural Pesticides [40 CFR 170.240{d){5)] for dermal protection. In addition, 

flaggers must wear long-sleeved shirt, long pants, shoes, and socks. 

USER SAFETY RECOMMENDATIONS 

Users should: 

• 

• Wash hands thoroughly with soap and water after handling and before eating, drinking, 

chewing gum, using tobacco, or using the toilet. 

• Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and 

put on clean clothing. 

• Remove PPE immediately after handling this product. Wash the outside of gloves 

before removing. As soon as possible, wash thoroughly and change into clean 

clothing. 

ENVIRONMENTAL HAZARDS 

For terrestrial uses, do not apply directly to water, or to areas where surface water is present, {'s to 

intertidal areas below the mean high water mark, except as specified on this label for application to rice.', 

Do not contaminate water when disposing of equipment wash waters. Apply thi&: 'pT?d~ct only as 

specified on this label. ' , . 

, 

, 

" 

-" , ", , ", , 

Filename: Thidiazuroo-DiufOll EC (429·081705) (RED 062806) clean Page 2 

93
STORAGE AND DISPOSAL 

Do not contaminate water, food, or feed by storage or disposal. 

PESTICIDE STORAGE: Store this product in a cool, dry place in its original container only. Container 

should be closed when not in use. Do not expose the product to open flame excessive heat. Store in 

original container and keep closed. 

PESTICIDE DISPOSAL: Pesticide wastes are acutely hazardous. Improper disposal of excess 

pesticide, spray mixture, or rinsate is a violation of Federal law. If these wastes cannot be disposed of 

by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or 

the Hazardous Waste representative at the nearest EPA Regional Office for guidance. 

CONTAINER DISPOSAL: Triple rinse (or equivalent); then offer for recycling or reconditioning, or 

puncture and dispose of in sanitary landfill, or by other procedures approved by State and local 

authorities. 

DO NOT REUSE EMPTY CONTAINER 

PHYSICAL OR CHEMICAL HAZARDS 

Do not use or store near heat or open flame. 

To Contain a Spill: Absorb liquid by covering it with cat litter, commercial clay, lime, sand, sawdust, or soda ash. 

Once absorbed, bury the cleaning materials and cleanse the spill area with a detergent and water solution. 

GENERAL INFORMATION 

TH1D1AZURON-DIURON EC is a harvest aid for cotton, used for leaf removal prior to harvest. 

THIDIAZURON-DIURON EC can be applied in most weather conditions, both warm and cool. 

USE PRECAUTIONS 

This product is not to be applied through any type of irrigation system. 

Effectiveness of TH1DIAZURON-DIURON EC will be reduced if rainfall occurs within 12 hours post 

application. 

Foliage from treated plants or gin trash is not to be fed to livestock. 

Rotation to the following crops requires the minimum specified periods below after the last 

application of THIDIAZURON-DIURON EC: 

small grains, sorghum, corn, or root crops (except carrots, onions) ................................. two (2) months 

legumes (including alfalfa) or leafy vegetable (except lettuce} ........................................ two (2) months 

cole crops, garlic, safflower, tomatoes, and watermelon ................................................ two (2) months 

carrots ............................................................................................................. three (3) months 

onions ............................................................................................................... four (4) months 

cantaloupe, honeydew melon/casaba melon, muskmelon, or peppers ........................... five (5) months 

lettuce ........................ when soil has been deep-plowed (12-15 inches) ....................... two (2) months 

OR lettuce ............. when soil is only disced (4-6 inches) .................................... nine (9) months 

All other crops ................................................................................................ twelve (12) months 

Special Note for inter-cropped grains and legumes planted either as cover crops or planted into 

treated fields before the minimum two (2) month plant back time after the final THIDIAZURON-DIURON 

EC application: Any such crops are prohibited for use as feed or food and may be used only as cover 

crops. 

Do not use immature crops for food or feed. 

Prevent spray drift from contacting crops other than mature cotton, since this product may 

defoliate or injure other plant species. 

Mixtures with organophosphates can increase nontarget crop phytotoxicity. Exercise additional care 

when lettuce, citrus, cantaloupes or any other edible crops are adjacent to THIDIAZURON-DIURON EC 

treated cotton fields. 

Filename: Thidiuzuron-Diuron EC (429-081705) (RED 062806) clean Page 3 

94
PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL ONTO NONTARGET CROPS 

Under windy weather conditions, applications of THIOIAZURON-DIURON EC may drift to non-target 

crops. 

The following procedures can help reduce the potential for drift: 

• If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground 

applications of THIDIAZURON-DIURON EC. 

• Nozzle pressure of 20-30 psi is recommended. 

• Do not apply this product during a temperature inversion because drift potentia! is high. In addition, 

do not apply this product if the development of a temperature inversion appears likely during the 

application period. 

• Do not apply this product by ground within 100 fee! or by air within 0.5 mile of lettuce. 

RIO GRANDE VALLEY OF TEXAS PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL 

The following procedures can help reduce the potential for drift: 

• If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground 

applications of THIDIAZURON-DIURON EC. If wind speeds are less than ten (10) miles per hour, 

observe local recommendations from your State Extension Cotton Specialist. 

• Nozzle pressure of 20-30 psi is recommended. 

• Do not apply this product during a temperature inversion because drift potential is high. In addition, 

do not apply this product if the development of a temperature inversion appears likely during the 

application period. 

• Use the maximum nozzle orifice size that provides proper coverage and deposition of this product. 

• CITRUS AREAS: Do not apply this product by ground within 0.5 mile or by air within 5 miles 

downwind of citrus in flush. 

DIRECTIONS FOR USE 

It is a violation of Federal law to use this product in a manner inconsistent with its labeling. 

Do not apply this product in a way that will contact workers or other persons, either directly or through 

drift. Only protected handlers may be in the area during application. 

Filename: ThidiazufOll-Diuron EC (429-081705) (RED 062806) clean Page 4 

95
AGRICULTURAL USE REQUIREMENTS 

Use this product only in accordance with jts labeling and with the Worker Protection Standard, 40 CFR 

Part 170. This Standard contains requirements for the protection of agricultural workers on farms, 

forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for 

training, decontamination, notification, and emergency assistance. It also contains specific instructions 

and exceptions pertaining to the statement on this label about personal protective equipment (PPE), and 

restrjcted~entry interval. The requirements in this box only apply to uses of this product that are covered 

by the Worker Protection Standard. 

Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 12 

hours. 

For minimum early entry PPE use the following: 

PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and 

that involves contact with anything that has been treated, such as plants, soil, or water, is: 

• Coveralls 

• Shoes plus socks 

• Chemical-resistant gloves made of any waterproof material 

• 

SPRAY DRIFT 

Requirements for reducing spray drift for diuron ground and aerial applications: 

Use best practices to avoid drift to all other crops and non-target areas. Do not apply when conditions 

favor drift from target areas. The interaction of many equipment- and weather-related factors determine 

the potential for spray drift. Avoiding spray drift at the application site is the responsibility of the 

applicator. The applicator must follow the most restrictive precartions to avoid drift, including those found 

in this labeling as well as applicable state and local regulations and ordinances. A drift control agent may 

reduce drift, however, it may also decrease weed control. 

Make aerial or ground applications only when the wind speed is less than or equal to 10 miles per hour. 

Do not make aerial or ground applications into temperature inversions. 

Apply with medium or coarser spray (according to ASAE standard 572) for standard nozzles. 

Additional requirements for ground appllcations: 

When applying to crops, apply with nozzle height no more than 2 feet above the ground or crop canopy. 

When applying to non-crop areas, use lowest nozzle height consistent with safety and efficacy. Direct 

spray into target vegetation. 

Additional requirements for aerial appllcations: 

The spray boom should be mounted on the aircraft so as to minimize drift caused by wing tip vortices. 

The boom length must not exceed 75% of the wingspan or 90% of rotor blade diameter. 

Use upwind swath displacement. 

When applying to crops, do not release spray at a height greater than 6 to 10 feet above the ground or 

crop canopy. When applying to non-crop areas, apply at a minimum safe altitude above the area being 

treated. 

Do not apply by air if sensitive non-target crops are within 100 feet of the application site. 

TIME OF APPLICATION 

THJDIAZURON-DIURON EC defoliant applications are to be made only on mature cotton plants when the 

uppermost harvestable boll is mature. Boll maturity is defined as 1) when a boll is squeezed between 

thumb and finger, it does not dent; 2) when cutting a cross section with a sharp knife is difficult; 3) when 

seeds in cross section lack liquid within the seed coat or outer edges of seed coat are light brown; and 4) 

when fully developed cotyledons are present. 

Filcllamc: Thidiazuron·DiUl'on EC (429-081705) (RED 062806) clcan Page 5 

96
Make applications ofTHIDIAZURON-DIURON EC at least 5 days prior to expected harvest date. 

NOTE: Adequate defoliation with THIOIAZURON-OIURON EC depends on three factors: 

• Cotton is actively growing. 

• High relative humid·lty. 

• Cotton plant leaves are turgid and not desiccated. 

ATTENTION: Desiccation and/or leaf freezing may occur during periods of high temperature when 

adjuvants are added to THIDIAZURON-DIURON EC application solution. Products and adjuvants 

known to cause desiccation of cotton leaf tissue should not be used. 

Under low nighttime temperatures (below 60°F) or otherwise adverse conditions, this product, when used 

alone, may provide less than expected defoliation and J or regrowth suppression. 

APPLICATION INFORMATION 

Use an adequate volume of water with the recommended amount of THIDIAZURON-DIURON EC 

defoliant to uniformly and completely cover leaves. For ground equipment, apply 10 - 25 gallon per acre 

and by air, use 2 -10 gallons per acre. Maintain agitation during application. 

DOSAGE INFORMATION 

Application Rate: Before harvest, use 0.4-1.0 pints active ingredient/acre (6.4-16 fl. oz.lA). 

One gallon of THIDIAZURON-OIURON EC will treat 8 - 20 acres. Refer to the dose rate table below. 

In some situations, a follow-up application maybe needed. THIDIAZURON-DIURON EC may be used for 

this application. Other defoliants may be needed. If additional boll opening is required, Ethephon 6 may 

be used at recommended rates; see product label for rates and timings. Consult your local State 

Extension Cotton Specialist recommendations for rateS and timings. 

The maximum annual use rate of THIOIAZURON-DIURON EC is 16 oz. per acre per season. 

MIXING INSTRUCTIONS 

1. Fill spray applicator tank with at least one half of the water to be used 

2. Start agitation 

3. Add the appropriate volume of THIDIAZURON -DIURON EC 

4. Continue agitation and fill tank with the remainder of the water to be used 

5. Agitation should continue throughout the application 

CALIFORNIA ONLY: PRECONDITIONING 

When used as a pre-condltioner seven to ten days before applicafion of this or other defoliant 

compounds, this product will improve the efficacy of such a defoliant application. Before use, observe all 

product label directions, recommendations and prohibitions on both product's labels. 

Application Rate: Use 4-6 f1.0Z. of this product/acre in an aerial application of 2-10 gallons of spray 

solution or ground application of 10-25 gallons of spray solution 

Filename: Thidiazuron-Diuron EC (429-081705) (RED 062806) clean Page 6 

97
APPLICATION RATE TABLE for THlDlAZURON DJURON EC · 

THIDIAZURON·DIURON EC One Gallon of THIDJAZURON~ Active Ingredients per Acre 

FonnuJated Product DJURON EC WllJ Treat 

6.4 oz.lAcre 20 Acres 0.075 Ibs. ai/Acre 

(0.4 pt./Acre) 

8.8oz.lAcre 15 Acres 0.10 Ibs. Ai/Acre 

(0.55 pt./Acre) 

12.8 Oz.lAC~~ 10 Acres 0.15 Jbs. Ai/Acre 

(0.8 pt./Acre 

16.0oz.lAcre 8 Acres 0.1875 Ibs. ai/Acre 

(1.0 pt./Acre) 

DO NOT APPLY MORE THAN 1.0 PINT OF THIDIAZURON·DIURON EC PER ACRE PER SEASON. 

IMPORTANT CLEAN OUT INSTRUCTIONS 

When applying THIDJAZURON-DIURON EC, a residue may form in application equipment. This residue 

can best be flushed oul of the spraying system by using a commercial tank cleaner when done while 

residue is still fresh and moist. DO NOT ALLOW EQUIPMENT TO DRY BEFORE CLEAN OUT. Consult 

your State Extension Cotton Specialist for recommended tank cleaners and cleaning procedures. 

Use tank cleaner and water immediately after application. Flush the entire system including nozzles, 

booms, application tanks, sumps, pumps, and transfer lines. Allowing the spray solution to dry in the 

application equipment can result in residues that are more difficult to remove. Dried residues are 

extremely difficult to remove. To remove such dried residues, fIJI the affected equipment to 

capacity with commercial tank cleaner solution and tet it remain for 7 days. Afterwards, the 

equipment will need to be thoroughly flushed and rinsed. 

Spray application equipment that has been inadequately cleaned will contain residue of THIDIAZURON ~ 

DIURON EC. Such improper cleaning could lead to crop damage in later applications. 

Micro Flo Company, LLC assumes no liability due to equipment that has not been properly 

cleaned. 

CONDITIONS OF SALE AND WARRANTY 

The Directions For Use of this product reflects the opinion of experts based on field use and tests. The 

directions are believed to be reliable and should be followed carefully. However, it is impossible to 

eliminate all risks inherently associated with use of this product. Crop injury, ineffectiveness or other 

unintended consequences may result because of such factors as weather conditions, presence of other 

materials, or use of the product in a manner inconsistent with its labeling, all of which are beyond the 

control of MICRO FLO COMPANY LLC ("MICRO FLO") or the Seller. All such risks shall be assumed by 

the Buyer. 

MICRO FLO warrants that this product conforms to the chemical description on the label and is 

reasonably fit for the purposes referred to in the Directions For Use, subject to the inherent risks, 

referred to above. 

MICRO FLO MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OR 

MERCHANTABILITY OR ANY OTHER EXPRESS OR IMPLIED WARRANTY. TO THE EXTENT 

PERMITTED BY LAW, MICRO FLO AND THE SELLER DISCLAIM ANY LIABILITY FOR 

CONSEQUENTIAL, SPECIAL OR INDIRECT DAMAGES RESULTING FROM THE USE OR HANDLING 

OF THIS PRODUCT. MICRO FLO and the Seller offer this product, and the Buyer and User accept it, 

subject to the foregoing Conditions of Sale and Warranty which may be varied only by agreement in 

writing signed by a duly authorized representative of MICRO FLO. 

Fi!ename: Thidiazuron-Diuron EC (429-081705) (RED 062806J clean Page 7 

98
EC 

COTTON DEFOLIANT 

For Agricultural Use Only 

ACTIVE INGREDIENTS: Thidiazuron: N-phenyl-N'-1,2,3-thidiazol-5-ylurea' " ..... 12% 

Diuron: 3-{3,4-dichlorophenyl)- t, 1-dimethylurea' .. ............... . ............................ 6% 

Other Ingredients: ............... .... . ................................. " .............. 

TOTAL .................................................................................................. tOO% 

Contains 1 lb. Thidiazuron per gallon and 0.5Ib. Diuron per gallon 

KEEP OUT OF REACH OF CHILDREN 

DANGER - PELIGRO 

Si usted no entiende Ia etiqueta, busque a algulen para que se la explique a usted 

en detalle. 

(If you do not understand this label, find someone to explain it to you in detail.) 

FIRST AID 

IF ON SKIN OR • Take off contaminated clothing, 

CLOTHING: • Rinse skin immediately with plenty of water for 15-20 

minutes. 

• Call a poison control center or doctor for treatment advice. 

IF IN EYES: • Hold eye open and rinse slowly and genUy with water for 15-

20 minutes. 

• Remove contact lenses, if present, after the first 5 minutes, 

then continue rinsing. 

• Call a poison control center or doctor for treatment advice. 

IF INHALED: · Move person to fresh air. 

• If person is not breathing, call 911 or an ambulance, then 

give artificial respiration, preferably mouth-to-mouth is 

possible. 

• Call a poison conlrol center or doctor for treatment advice. 

IF SWALLOWED: • Immedialely call a poison control cenler or doctor for 

treatment advice. 

• Do not induce vomiting unless told to do so by a poison 

control cenler or doclor. 

• Have person sip a glass or water if able to swallow, 

• Do not oive anvthino bv mouth 10 an unconscious person. 

NOTE TO PHYSiCIAN: Probable mucosal damage may contraindicate the use of 

gastric lavage. 

HOT LINE NUMBER 

Have the product container or label with you when calling a poison control center 

or doctor or going for treatment. 

EMERGENCY NUMBERS: 

• Transportation or spill, call CHEMTREC 800-424·9300. • Human health, 800_832_HElP (4357). 

• Animal health, call ASPCAat 800·345-4735. 

Filename. Thidiazuroll-Diuron EC (429-081705) (RED 062806) clean 

PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS AND DOMESTIC ANIMALS DANGER 

COrrosive. causes irreversible eye damage, Causes burns

get in eyes, on skin, or on clothing. Avoid breathing dust or 

frequently repeated skin-contact may cause allergic reaction

ENVIRONMENTAL HAZARDS 

For terrestrial uses, do not apply directly to water, or to 

present, or to intertidal areas below the mean high water ma

label for application to rice. Do not contaminate water when 

waters. Apply this product only as specified on this label. 

SToRAGE AND DISPOSAL 

Do not contaminate water, food, or feed by storage or d·lsp

PESTICIDE STORAGE: Store this product in a cool, dry p

only. Container should be closed when not in use. Do not 

flame excessive heat. Store in original container and keep 

PESTICIDE DISPOSAL: Pesticide wastes are acutely haz

of excess pesticide, spray mixture, or tinsate is a violation 

wastes cannot be disposed of by use according to label ins

Pesticide or Environmental Control Agency, or the Hazard

the nearest EPA Regional Office for guidance. 

CONTAINER DISPOSAL: Triple rinse (or equivalent); then 

reconditioning, or puncture and dispose of in sanitary landf

approved by Stale and local authorities. 

DO NOT REUSE EMPTY CONTAINER 

PHYSICAl OR CHEMICAL HAZARDS 

Do not use or store near heat or open flame. 

ToContain a Spill: Absorb liquid by covering it with cat litte

sand, sawdust, or soda ash. Once absorbed, bury the clean

spill area with a delergent and water solution. 

DIRECTIONS FOR USE 

It is a violation of Federal law to use this product in a 

labeling. 

SEE ATTACHED BOOKLET FOR ADDITIONA

AND USE DIRECTIONS 

EPA Reg. No. 51036429 

EPA Est. No. 51036-GA-001 

AD081705 

NET CONTENTS: __ _ 

BASE LABEL 

Page 8 
THIDIAZURON-DIURON EC 

COTTON DEFOLIANT 

For Agricultural Use Only 

ACTIVE INGREDIENTS: Thidiazuron: N-phenyl-N'-1 ,2,3-thidiazol-5-ylurea*" ..................... 12% 

Diuron: 3-(3,4-dichlorophenyl)-1, 1-dimethylurea* ............................................................ 6% 

OTHER INGREDIENTS: ............................................................................... " ......... 82% 

TOTAL 100% 

Contains 1 lb. Thidiazuron per gallon and 0.5 lb. Diuron per gallon 

KEEP OUT OF REACH OF CHILDREN 

DANGER - PELIGRO 

Si usted no entiende la etiqueta, busque a alguien para que 5e la explique a usted en detalle. 

(If you do not understand this label, find someone to explain it to you in detail.) 

FIRST AID 

IF ON SKIN OR • Take off contaminated clothing. 

CLOTHING: • Rinse skin immediately with plenty of water for 15-20 minutes. 

• Call a poison control center or doctor for treatment advice. 

IF IN EYES: • Hold eye open and rinse slowly and gently with water for 15-20 minutes. 

• Remove contact lenses, if present, after the firs! 5 minutes, then continue 

rinsing. 

• Call a poison control center or doctor for treatment advice. 

IF INHALED: • Move person to fresh air. 

• If person is not breathing, call 911 or an ambulance, then give artificial 

respiration, preferably mouth-la-mouth is possible. 

• Call a poison control center or doctor for treatment advice. 

IF SWALLOWED: • Immediately call a poison control center or doctor for treatment advice. 

• Do not induce vomiting unless told to do so by a poison control center or 

doctor. 

• Have person sip a glass or water if able to swallow. 

• Do not give anythinq by mouth to an unconscious person. 

NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate the use of gastric 

lavage. 

HOT LINE NUMBER 

Have the product container or label with you when calling a poison control center or doctor 

or going for treatment. 

EMERGENCY NUMBERS: 

• Transportation or spill, call CHEMTREC 800-424-9300 . 

• Human and Animal health, 866-303-6952 

SEE INSIDE (SIDE PANEL) FOR ADDITIONAL PRECAUTIONS AND USE DIRECTIONS" , , , 

EPA Reg. No. 51036-429 

AD X)()()()(X 

Manufactured by 

Micro Flo Company LLC 

P. O. Box 772099 

Memphis, TN 38117 

Filename: Thidiazuron-Diuron EC (429-081705) (RED 062806) elean 

EPA Est. No. 51036-GA-OO'1 

NET CONT~~T~,:':-__ _ 

, 

" " 

'" , 

Page 1 

100
PRECAUTIONARY STATEMENTS 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

DANGER 

Corrosive. Causes irreversible eye damage. Causes burns. Harmful if inhaled. Do not get in eyes, on 

skin, or on clothing. Avoid breathing dust or spray mis!. Prolonged or frequently repeated skin~contact 

may cause allergic reactions in some individuals. 

PERSONAL PROTECTIVE EQUIPMENT 

Some materials that are chemical~resistant to this product are barrier laminate or butyl rubber gloves. If 

you want more options, follow the instructions for category C on an EPA chemical-resistance category 

selection char\. 

All pilots, flaggers, and groundboom applicators must wear: 

• Long"sleeved shirt and long pants and, 

• Shoes plus socks 

All mixers, loaders, other applicators, and other handlers must wear: 

• Long-sleeved shirt and long pants, 

• Shoes plus socks, 

• Chemical resistant gloves, such as barrier laminate or butyl rubber gloves 

• A NIOSH-approved dust/mist filtering respirator with any N2

, R, P or HE filter or an NIOSH-approved 

dust/mist filtering respirator with approval number prefix TC-21C. 

• Chemical-resistant apron when mixing, loading, or cleaning equipment or spills 

Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables 

exist, use detergent and hot water. Keep and wash PPE separately from other laundry. 

ENGINEERING CONTROLS STATEMENT 

Pilots must use an enclosed cockpit that meets the requirements, listed in the Worker Protection 

Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)]. 

Flaggers supporting aerial applications must use an enclosed cab that meets the definition in the Worker 

Protection Standard for Agricultural Pesticides [40 CFR 170.240(d)(5)] for dermal protection. In addition, 

flaggers must wear long-sleeved shirt, long pants, shoes, and socks. 

USER SAFETY RECOMMENDATIONS 

Users should: 

• 

• Wash hands thoroughly with soap and water after handling and before eating, drinking, 

chewing gum, using tobacco, or using the toilet. 

• Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and 

put on clean clothing. 

• Remove PPE immediately after handling this product. Wash the outside of gloves 

before removing. As soon as possible, wash thoroughly and change into clean 

clothing. 

ENVIRONMENTAL HAZARDS 

For terrestrial uses, do not apply directly to water, or to areas where surface water is present, or to 

intertidal areas below the mean high water mark, except as specified on this label for applicatlon to rice. 

Do not contaminate water when disposing of equipment wash waters. Apply this product only as 

specified on this label. 

Filename: TIlidiazuron-Diuron EC (429-08)705) (RED 062806) clean Page 2 

101
STORAGE AND DISPOSAL 

Do not contaminate water, food, or feed by storage or disposal. 

PESTICIDE STORAGE: Store this product in a cool, dry place in its original container only. Container 

should be closed when no! in use. Do not expose the product to open flame excessive heat. Store in 

original container and keep closed. 

PESTICIDE DISPOSAL: Pesticide wastes are acutely hazardous. Improper disposal of excess 

pesticide, spray mixture, or rinsate is a violation of Federal law. If these wastes cannot be disposed of 

by use according to label instructions, contact your State Pesticide or Environmental Control Agency, or 

the Hazardous Waste representative at the nearest EPA Regional Office for guidance. 

CONTAINER DISPOSAL: Triple rinse (or equivalent); then offer for recycling or reconditioning, or 

puncture and dispose of in sanitary landfill, or by other procedures approved by State and local 

authorities. 

DO NOT REUSE EMPTY CONTAINER 

PHYSICAL OR CHEMICAL HAZARDS 

Do not use or store near heat or open flame. 

To Contain a Spill: Absorb liquid by covering it with cat litter, commercial clay, lime, sand, sawdust, or soda ash. 

Once absorbed, bury the cleaning materials and cleanse the spill area with a detergent and water solution. 

GENERAL INFORMATION 

THIDIAZURON-DIURON EC is a harvest aid for cotton, used for leaf removal prior to harvest. 

THIDIAZURON-DIURON EC can be applied in most weather conditions, both warm and cool. 

USE PRECAUTIONS 

This product is not to be applied through any type of irrigation system. 

Effectiveness of THIDIAZURON-DIURON EC will be reduced if rainfall occurs within 12 hours post 

application. 

Foliage from treated plants or gin trash is not to be fed to livestock. 

Rotation to the following crops requires the minimum specified periods below after the last 

application ofTHIDIAZURON-DIURON EC: 

small grains, sorghum, corn, or root crops (except carrots, onions) ................................. two (2) months 

legumes (including alfalfa) or leafy vegetable (except lettuce) ........................................ two (2) months 

cole crops, garlic, safflower, tomatoes, and watermelon ................................................ two (2) months 

carrots ............................................................................................................. three (3) months 

onions .............................................................................................................. .four (4) months 

cantaloupe, honeydew melon/casaba melon, muskmelon, or peppers .......................... .five (5) months 

lettuce ........................ when soil has been deep-plowed (12-15 inches) ....................... two (2) months 

OR lettuce ............. when soil is only disced (4-6 inches) ...... .......... .. .............. nine (9) months 

All other crops ................................................................................................ twelve (12) months 

Special Note for inter-cropped grains and legumes planted either as cover crops or planted into 

treated fields before the minimum two (2) month plant back time after the final THIDIAZURON-DIURON 

EC application: Any such crops are prohibited for use as feed or food and may be used only as cover 

crops. 

Do not use immature crops for food or feed. 

Prevent spray drift from contacting crops other than mature cotton, since this product may 

defoliate or injure other plant species. 

Mixtures with organophosphates can increase nontarget crop phytotoxicity. Exercise additional care 

when lettuce, citrus, cantaloupes or any other edible crops are adjacent to THIDIAZURON-DIURON EC 

treated cotton fields. 

Filename: ThidiaZUl'on·DillfOll EC (429-081705) (RED 062806) clean Page 3 

102
PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL ONTO NONTARGET CROPS 

Under windy weather conditions, applications of THIDIAZURON-DIURON EC may drift to non-target 

crops. 

The following procedures can help reduce the potential for drift: 

• If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground 

applications of THIDIAZURON-DIURON EC. 

• Nozzle pressure of 20-30 psi is recommended. 

• Do not apply this product during a temperature inversion because drift potential is high. In addition, 

do not apply this product if the development of a temperature inversion appears likely during the 

application period. 

• Do not apply this product by ground within 100 feet or by air within 0.5 mile of lettuce. 

RIO GRANDE VALLEY OF TEXAS PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL 

The following procedures can help reduce the potential for drift: 

• If wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground 

applications of THIDIAZURON-DIURON EC. If wind speeds are less than ten (10) miles per hour, 

observe local recommendations from your State Extension Cotton Specialist. 

• Nozzle pressure of 20-30 psi is recommended. 

• Do not apply this product during a temperature inversion because drift potential is high. In addition, 

do not apply this product if the development of a temperature inversion appears likely during the 

application period. 

• Use the maximum nozzle orifice size that provides proper coverage and deposition of this product. 

• CITRUS AREAS: Do not apply this product by ground within 0.5 mile or by air within 5.miles 

downwind of citrus in flush. 

DIRECTIONS FOR USE 

It is a violation of Federal law to use this product in a manner inconsistent with its labeling. 

Do not apply this product in a way that will contact workers or other persons, either directly or through 

drift. Only protected handlers may be in the area during application. 

Filename: Thidia7.uron-Diuron EC (429-081705) (RED 062806) clean Page 4 

103
AGRICULTURAL USE REQUIREMENTS 

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR 

Par! 170. This Standard contains requirements for the protection of agricultural workers on farms. 

forests, nurseries, and greenhouses, and handlers of agricultural pesticides. It contains requirements for 

training, decontamination, notification, and emergency assistance. It also contains specific instructions 

and exceptions pertaining to the statement on this label about personal protective equipment (PPE), and 

restrjcted~entry interval. The requirements in this box only apply to uses of this product that are covered 

by the Worker Protection Standard. 

Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 12 

hours. 

For minimum early entry PPE use the following: 

PPE required for early entry to treated areas that is permitted under the Worker Protection Standard and 

that involves contact with anything that has been treated, such as plants, soil, or water, is: 

• Coveralls 

• Shoes plus socks 

• Chemical-resistant gloves made of any waterproof material 

• 

SPRAY DRIFT 

Requirements for reducing spray drift for diu ron ground and aerial applications: 

Use best practices to avoid drift to all other crops and non-target areas. Do not apply when conditions 

favor drift from target areas. The interaction of many equipment- and weather-related factors determine 

the potential for spray drift. Avoiding spray drift at the application site is the responsibility of the 

applicator. The applicator must follow the most restrictive precartions to avoid drift, including those found 

in this labeling as well as applicable state and local regulations and ordinances. A drift control agent may 

reduce drift, however, it may also decrease weed control. 

Make aerial or ground applications only when the wind speed is less than or equal to 10 miles per hour. 

Do not make aerial or ground applications into temperature inversions. 

Apply with medium or coarser spray (according to ASAE standard 572) for standard nozzles. 

Additional requirements for ground applications: 

When applying to crops, apply with nozzle height no more than 2 feet above the ground or crop canopy. 

When applying to non-crop areas, use lowest nozzle height consistent w·lth safety and efficacy. Direct 

spray into target vegetation. 

Additional requirements for aerial applications: 

The spray boom should be mounted on the aircraft so as to minimize drift caused by wing tip vortices. 

The boom length must not exceed 75% of the wingspan or 90% of rotor blade diameter. 

Use upwind swath displacement. 

When applying to crops, do not release spray at a height greater than 6 to 10 feet above the ground or 

crop canopy. When applying to non-crop areas, apply at a minimum safe altitude above the area being 

treated. 

Do not apply by air if sensitive non-target crops are within 100 feet of the application site. 

TIME OF APPLICATION 

THIDIAZURON-OIURON EC defoliant applications are to be made only on mature cotton plants when the 

uppermost harvestable boll is mature. Boll maturity is defined as 1) when a boll is squeezed between 

thumb and finger, it does not dent;" 2) when cutting a cross section with a sharp knife is difficult; 3) when 

seeds in cross section lack liquid within the seed coat or outer edges of seed coat are light brown; and 4) 

when fully developed cotyledons are present. 

Filename: Thidiazuron-Diuron EC (429-081705) (RED 062806) clean Page 5 

104
Make applications of THIDIAZURON-DIURON EC at least 5 days prior to expected harvest date. 

NOTE: Adequate defoliation with THIDIAZURON-DIURON EC depends on three factors: 

• Cotton is actively growing. 

• High relative humidity. 

• Cotton plant leaves are turgid and not desiccated. 

ATTENTION: Desiccation and/or leaf freezing may occur during periods of high temperature when 

adjuvants are added to THIDIAZURON-DIURON EC application solution. Products and adjuvants 

known to cause desiccation of cotton leaf tissue should not be used. 

Under low nighttime temperatures (below 60°F) or otherwise adverse conditions, this product, when used 

alone, may provide less than expected defoliation and / or regrowth suppression. 

APPLICATION INFORMATION 

Use an adequate volume of water with the recommended amount of THIDIAZURON-DIURON EC 

defoliant to uniformly and completely cover leaves. For ground equipment, apply to - 25 gallon per acre 

and by air, use 2 -10 gallons per acre. Maintain agitation during application. 

DOSAGE INFORMATION 

Application Rate: Before harvest, use 0.4-1.0 pints active ingredient/acre (6.4-16 fl. oz.lA). 

One gallon of THIOIAZURON-DIURON EC will treat 8 - 20 acres. Refer to the dose rate table below. 

In some situations, a follow-up application maybe needed. THIDIAZURON-OIURON EC may be used for 

this application. Other defoliants may be needed. If additional boll opening is required, Ethephon 6 may 

be used at recommended rates; see product label for rates and timings. Consult your local State 

Extension Cotton Specialist recommendations for rates and timings. 

The maximum annual use rate of THIDIAZURON-DIURON EC is 16 oz. per acre per season. 

MIXING INSTRUCTIONS 

1. Fill spray applicator tank with at least one half of the water to be used 

2. Start agitation 

3. Add the appropriate volume of THIDIAZURON -DIURON EC 

4. Continue agitation and fill tank with the remainder of the water to be used 

5. Agitation should continue throughout the application 

CALIFORNIA ONLY: PRECONDITIONING 

When used as a pre-conditioner seven to ten days before application of this or other defoliant 

compounds, this product will improve the efficacy of such a defoliant application. Before use, observe all 

product label directions, recommendations and prohibitions on both product's labels. 

Application Rate: Use 4-6 f1.02. of this product/acre in an aerial application of 2-10 gallons of spray 

solution or ground application of 10-25 gallons of spray solution 

Filename: Thidiazuron-Diuron EC (429-081705) (RED 062806) clean Page 6 

105
APPLICATION RATE TABLE forTHtDIAZURON -DIU RON EC 

THIDIAZURON-DIURON EC One Gallon of TH[D[AZURON~ Active Ingredients per Acre 

Formulated Product D[URON EC Will Treat 

6.4 oz.lAcre 20 Acres O.075Ibs. ai/Acre 

(004 pUAere) 

8.8 oz.lAcre 15 Acres 0.10 Ibs. Ai/Acre 

(0.55 pUAere) 

;,2.8 OZ'/Ae:~ 10 Acres 0.15 Ibs. Ai/Acre 

0.8 pt.!Acre 

16.0 oz.lAcre 8 Acres 0.1875 tbs. ai/Acre 

(1.0 pUAere) 

DO NOT APPLY MORE THAN 1.0 PINT OF THIDIAZURON-DIURON EC PER ACRE PER SEASON. 

IMPORTANT CLEANOUT INSTRUCTIONS 

When applying TH[DIAZURON~D[URON EG, a residue may form in application equipment. This residue 

can best be flushed out of the spraying system by using a commercial tank cleaner when done while 

residue is still fresh and moist. DO NOT ALLOW EQUIPMENT TO DRY BEFORE CLEANOUT. Consult 

your State Extension Cotton Specialist for recommended tank cleaners and cleaning procedures, 

Use tank cleaner and water immediately after application, Flush the entire system including nozzles, 

booms, application tanks, sumps, pumps, and transfer lines. Allowing the spray solution to dry in the 

application equipment can result in residues that are more difficult to remove. Dried residues are 

extremely difficult to remove. To remove such dried residues, fill the affected equipment to 

capacity with commercial tank cleaner solution and let it remain for 7 days. Afterwards, the 

equipment will need to be thoroughly flushed and rinsed. 

Spray application equipment that has been inadequately cleaned will contain residue of THIDIAZURON -

DIURON EC. Such improper cleaning could lead to crop damage in later applications. 

Micro Flo Company, LLC assumes no liability due to equipment that has not been properly 

cleaned. 

CONDITIONS OF SALE AND WARRANTY 

The Directions For Use of this product reflects the opinion of experts based on field use and tests. The 

directions are believed to be reliable and should be followed carefully. However, it is impossible to 

eliminate all risks inherently associated with use of th'ls product. Crop 'Injury, ineffectiveness or other 

unintended consequences may result because of such factors as weather conditions, presence of other 

materials, or use of the product in a manner inconsistent with its labeling, all of which are beyond the 

control of MICRO FLO COMPANY LLC ("MICRO FLO") or the Seller. All such risks shall be assumed by 

the Buyer. 

MICRO FLO warrants that this product conforms to the chemical description on the label and is 

reasonably fit for the purposes referred to in the Directions For Use, subject to the inherent risks, 

referred to above. 

MICRO FLO MAKES NO OTHER EXPRESS OR IMPLIED WARRANTY OF FITNESS OR 

MERCHANTABILITY OR ANY OTHER EXPRESS OR IMPLIED WARRANTY. TO THE EXTENT 

PERMITIED BY LAW, MICRO FLO AND THE SELLER DISCLAIM ANY LIABILITY FOR 

CONSEQUENTIAL, SPECIAL OR INDIRECT DAMAGES RESULTING FROM THE USE OR HANDLING 

OF THIS PRODUCT. MICRO FLO and the Seller offer this product, and the Buyer and User accept it, 

subject to the foregoing Conditions of Sale and Warranty which may be varied only by agreement in 

writing signed by a duly authorized representative of MICRO FLO. 

Filename: Thidiazuron-Diuron EC (429·081705) (RED 062806) clean Page 7 

106
THIDIAZURONwDIURON EC 

COTTON DEFOLIANT 

For Agricultural Use Only 

ACTIVE INGREDIENTS; Thidiazuron: N-phenyl-N'-1,2,3_thidiazol_5_ylurea" ...•.•...... 12% 

Diuron: 3-(3,4-dichlorophenyl)-1,1-dimethylurea· •..•.................•..•.........•..•.•......... 6% 

Other Ingredients; .................................................................................... 82% 

TOTAL .......••.•.................••.....•........•.•............•.•.•................•.•..........•..•. 100% 

Contains t lb. Thidiazuron per gallon and 0.5 lb. Diuron per gallon 

KEEP OUT OF REACH OF CHILDREN 

DANGER - PELIGRO 

Si usted no entiende la ettqueta, busque a alguien para que se la expUque a usted 

en detalle. 

(If you do not understand this label, find Someone to explain it to you in detail.) 

• 

CLOTHING: 

• • 

• 

• • 

• 

• 

off _ 

Rinse skin immediately with plenty of water for 15-20 

minutes. 

20 minules. 

Remove contact lenses, if present, after the first 5 minuleS. 

then continue rinsing. 

If person is not breathing, call 911 or an ambulance, then 

give artificial respiration, preferably mouth-to-mouth is 

possible. 

cenleror 

trealment 

Do not induce vomiting unless told to do so by a poison 

control center or doctor. 

Have person sip a glass or water if able to swallow. 

Do not give anything by mouth to an UI 

obable mucosal damage may cont 

you 

Transportation or spill, calt CHEMTREC 800-424-9300. 

• Human 

Filename. ·rhidial.\\roll-Diul'Oll EC (429-081705) (RED 062806) clean 

PRECAUTIONARY STATEMENTS HAZARDS TO HUMANS AND DOMESTIC ANIMAlS DANGER 

Corrosive. Causes irreversible eye damage. Causes burns

get in eyes. on skin, or on clothing. Avoid breathing dust o

frequently repeated skin-contact may cause allergic reacJio

ENVIRONMENTAL HAZARD

For terrestrial uses, do not apply directly to water, or to 

present, or to intertidal areas below the mean high water m

label for application to rice. Do not contaminate water whe

waters. Apply this product only as spedfied on this label. 

STORAGE AND DiSPOSAl 

Do not contaminate water, food, or feed by storage or dis

PESTICIDE STORAGE: Store this product in a cool, dl)' 

only. Container should be closed when not in use. Do no

flame excessive heal. Store in original container and keep 

PESTICIDE DISPOSAL: Pesticide wastes are acutely ha

of excess pesticide, spray mixture, or rinsate is a violation 

wasles cannot be disposed of by use according to label in

Pesticide or Environmental Control Agency, or the Hazard

the nearest EPA Regional Office for guidance. 

CONTAINER DISPOSAL: Triple rinse (or equivalent): the

reconditioning, or puncture and dispose of in sanital)' land

approved by State and local authorities. 

DO NOT REUSE EMPTY CONTAINER 

PHYSICAL OR CHEMICAl HAZARDS 

Do not use or slore near heat or open flame. 

To Contain a Spilt: Absorb liquid by covering it with cat lit

sand, sawdust, or soda ash. Once absorbed, bul)' the clea

spilt area with a detergent and water solution. 

DIRECTIONS FOR USE 

It is a violation of Federal law to use this product in a 

labeling. 

SEE ATTACHED BOOKLET FOR ADDITION

AND USE DIRECTIONS 

EPA Reg. No. 51036-429 

EPA Est. No. 51036-GA-001 

AD081705 

NET CONTENTS: __ _ 

BASE LABEL 

Page 8 
Micro Flo Company LLC 

P.O. Box 772099 

Memphis, TN 38117 

PRODUCT NAME: Thidiazuron-Diuron EC 

EPA File Symbol: 51036-429 

DATA WAIVER REQUEST 

OPPTS Guideline 830.6319 

The purpose of this test is to obtain information and determine the miscibility for a 

product. This test is intended to determine whether a pesticide solution is 

suitable for application after dilution with oil or other nonpolar solvents, where 

applicable, instead of water. 

Thidiazuron-Diuron EC is made up with emulsifiers that work only when 

diluted in water. The label for this product is written to limit the application of this 

product in water and/or tank mixes with water. 

For this reason we are requesting a waiver of this data requirement. 

Reference: 

Product Proper/ies Test Guide/ines: OPPTS 830.1000, Background for 

Product Proper/ies Test Guidelines; EPA 712-C-96-310. August 1996 

MFC Waiver 51 036-432 (830.6319) 1 

, ~ , ' , . , ' 

108

*Inert ingredient information may be entitled to confidential treatment*
Micro Flo Company LLC 

P.O. Box 772099 

Memphis, TN 38117 

PRODUCT NAME: Thidiazuron-Diuron EC 

EPA File Symbol: 51036-429 

DATA WAIVER REQUEST 

OPPTS Guideline 830.6321 

The purpose of this test is to determine the potential for hazard when the 

pesticide product is used on or in the vicinity of electrical equipment and 

electrical conduits. Data is required when the end-use product is a 

nonconductant liquid and is to be used around electrical equipment. 

Thidiazuron-Diuron EC is formulated with nonconductant solvents. but it is 

not designed to be used around electrical equipment or electrical conduits. 

Thidiazuron-Diuron EC is a cotton harvest aide and is not labeled for use around 

electrical equipment of electrical conduits. 

For this reason we are requesting a waiver of this data requirement. 

Reference: 

Product Properties Test Guidelines: OPPTS 830.1000, Background for 

Product Properties Test Guidelines; EPA 712-C-96-310, August 1996 

MFC Waiver 51 036·432 (830.6321) 1 

109

*Inert ingredient information may be entitled to confidential treatment*
MATERIAL TO BE ADDED TO JACKET 

REG # 

Description: 

if applicable, check all that are attached 

new stamped accepted label en ~ . ~. .. 0. . 

new CSF .. -

D 1° 

.. ···0.·. 

notification en· D (') '. 

Instructions: 

Attach this sheet to the top of ALL material sent to the file room (both loose paper and 

new material in jackets). This sheet will be imaged; a clear description will aid in 

finding material in the e-jacket Remove staples from all material. If returning loose 

paper then hold together with a binder or paper clip. CSFs should be placed in the 

CSF folder (if returning jacket) or covered with a red CBI sheet (if returning loose 

paper). Material to be returned to file room should be place in the appropriate bin. 

Reviewer's 

Name: 

Phone: 

.. ~ Date: ~cP+/-,,(~S'+4-,,')'-,L)'--_ 

Division: 6'1 

110
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON. D.C. 20460 

AUG 1 5 2007 

Arysta LifeScience North America Corporation 

15401 Weston Parkway, Suite 150 

Cary, NC 27513 

OFFICE OF 

PREVENTION. PESTICIOES AND 

TOXIC SUBSTANCES 

Subject: EPA Reg. # 66330-333 I Thidiazuron-Diuron EC Cotton Defoliant Diuron 

Reregistration 

The amended label for EPA Reg. 66330-333 / Thidiazuron-Diuron EC Cotton Defoliant is 

acceptable provided the following changes are made to the label: 

1. The order of the First Aid sections should be "If In Eyes, If on Skin or Clothing, If 

Inhaled, and If Swallowed". 

2. The Note to Physician should be revised to address eye initation concerns. 

3. Change the Hazards to Humans and Domestic Animals statements to "Corrosive. Causes 

irreversible eye damage. Causes skin initation. Do not get in eyes, on skin, or on 

clothing.". 

4. Change the PPE statements to "Some materials that are chemical-resistant to this product 

are made ofbanier laminate or butyl rubber. If you want more options, follow the 

instructions for category C on an EPA chemical-resistance selection chart. All pilots and 

flaggers must wear: Long-sleeved shirt and long pants, Shoes and socks. All mixers, 

loaders, other applicators, and other handlers must wear: Coveralls over short-sleeved 

shirt and short pants, Socks plus chemical-resistant footwear, Chemical-resistant gloves, 

Googles, face shield or glasses, Chemical-resistant apron when mixing, loading or 

cleaning equipment or spills, and Chemical-resistant headgear for overhead exposure. In 

addition to the PPE above, all handlers except for ground boom applicators, pilOts, and 

fiaggers must also wear a NIOSH approved particulate filtering respirator equipped with 

N, R, or P class filter media. The respirator should have a NIOSH approval number 

prefix TC-84A. It is recommended that you require that the respirator wearer be fit 

tested, and trained in the use, maintenance, and limitations of the respirator." to comply 

with the Diuron RED. 

5. On page 2, after "Keep and wash PPE separately from other laundry" add "Discard 

clothing and other absorbent materials that have been drenched or heavily contaminated 

with this product's concentrate. Do not reuse them." to comply with the Diuron RED. 

6. To the Application Instructions section, add "Apply a maximum oftwo applications per 

year. Minimum retreatment interval is 21 days.". 

7. Change the Environmental Hazards statements to "Do not apply directly to water, or to 

111
areas where surface water is present or to intertidal areas below the mean high water 

mark. Do not contaminate water when disposing of equipment washwater or rinsate." 

''This product may contaminate water through drift of spray in wind. This product has a 

high potential for runoff for several months or more after application. Poorly draining 

soils and soils with shallow water tables are more prone to produce runoff that contains 

this product. A level, well-maintained vegetative buffer strip between areas to which this 

product is applied and surface water features such as ponds, streams, and springs will 

reduce the potential for contamination of water from runoff. Runoff of this product will 

be reduced by avoiding applications when rainfall is forecasted to occur within 48 hours. 

Sound erosion control practices will reduce this product's contribution to surface water 

contamination!' "This chemical has properties and characteristics associated with 

chemicals detected in ground water. Use of this chemical in areas where soils are 

permeable, particularly where the water table is shallow, may result in groundwater 

contamination." to comply with the Thidiazuron RED. 

8. To the Conditions of Sale change "Arysta disclaims all" to "To the extent consistent with 

applicable law, Arysta disclaims all "and "To the extent permitted by law" to "To the 

extent consistent with applicable law". 

9. Change the REI to "24 hours" to comply with the Thidiazuron RED. 

10. To the Procedures to Lower Spray Drift Potential onto Non Target Crops section delete 

"Do not apply this product by ground within 100 feet or by air within O.S mile of lettuce" 

and add "Thidiazuron products can not be applied by air within ;h mile oflettuce or S 

miles downwind of the point of application when citrus is in flush (burst of new growth, 

as in springtime) in the Rio Grande valley of Texas. Ground applications are restricted to 

100 feet away from lettuce and ~ mile downwind from the point of application for citrus. 

(In general, a decrease in droplet size or increase in wind speed at the time of application 

will result in risk to non-target organisms. Alternatively, if droplet size is coarser or wind 

speeds are lower, exposures due to drift would be reduced)." to the Rio Grande Valley of 

Texas Procedures to Lower Spray Drift Potential section to comply with the Thidiazuron 

RED. 

11. To the Application Rate Table under the heading ail A change 0.075 to 0.05, 0.1 to 0.07, 

0.15 to 0.1, and 0.1875 to 0.125. 

If you have any questions please call Erik Kraft at 703-308-9358. 

Sincerely, 

Joanne Miller 

Product Manager 23 

Herbicide Branch 

Registration Division (7S0SP) 

112
THIDIAZURON-DIURON EC 

COTTON DEFOLIANT 

For Agricultural Use Only 

ACCEPTED 

with COMMENTS 

In EPA Letter D2ted: 

AUG 1 5 2007 

Under the Federal tnseclicide, 

FlIllgicide, and RodentiddeAct 

as Ilmended, for the pesticide 

registered under EPA Reg. No. 

{U30-333 

ACTIVE INGREDIENTS: Thidiazuron: N-phenyl-N' 1.2,3-1hidiazol-5-ylurea"", 

Diuron: 3-(3,4-dichlorophenyl)-1, 1-dimethylurea* .. 

............... 12% 

. ....... 6% 

OTHER INGREDIENTS:. . ....... 82% 

, 

I 

TOTAL 100% 

Contains 1 lb. Thidiazuron per gallon and 0.5 lb. Diuron per gallon 

KEEP OUT OF REACH OF CHILDREN 

DANGER - PELIGRO 

51 usted no entiende la etiqueta, busque a alguien para que se fa explique a usted en detalle. 

(If you do not understand this label, find someone to explain it to you in detail.) 

FIRST AID 

IF ON SKIN OR • Take off contaminated clothing. 

CLOTHING: • Rinse skin immediately with plenty of water for 15-20 minutes. 

• Call a poison control center or doctor for treatmenl advice. 

IF IN EYES: • Hold eye open and rinse slowly and gently with waler for 15-20 minutes. 

• Remove conlact lenses, if presenl, after Ihe first 5 minules, then continue 

rinsing. 

• Call a poison control center or doctor for Ireatment advice. 

IF INHALED, • Move person to fresh air. 

• If person is nol breathing, call 911 or an ambulance, then give artificial 

respiration, preferably mouth-to-mouth is possible. 

• Call a poison conlrol center or doctor for trealmenl advice. 

IF SWALLOWED: , 

• Immediately call a poison control center or doclor for treatment advice. 

• Do not induce vomiting unless told to do so by a poison conlrol center or 

doctor. 

• Have person sip a glass or waler if able to swallow. 

I· Do not qive anythinq by moulh to an unconscious person 

NOTE TO PHYSICIAN: Probable mucosal damage may contraindicate the use of gastric 

lavage, 

HOT LINE NUMBER 

Have the product container or label with you when calling a pOison control center or doctor 

I or 'going for treatment. 

I EMERGENCY NUMBERS: J 

• Transportation or spill, call CHEMTREC 800·424-9300. l 

____ , ___ H_u_m_a_n_a_n_d_A __ n_im __ 'I_h_e_a_l_th_,_B_S_S_-3_0_3_-S_9_5_2 ________________________________ __ 

SEE INSIDE (SIDE PANEL) FOR ADDITIONAL PRECAUTIONS AND USE DIRECTIONS 

EPA Reg. No. 66330-333 

AD XXXXXX 

EPA Est. No. 51036·Gh·001 

NET CONTt:fIIl S. ______ __ 

Manufactured for 

Arysta UfeScience North America Corporation 

15401 Weston Parkway, Suite 150 

Cary. NC 27513 

113
PRECAUTIONARY STATEMENTS 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS 

DANGER 

Corrosive. Causes irreversible eye damage. Causes burns. Harmful if inhaled. Do nol get in eyes, on 

skin, or on clothing. Avoid breathing dust or spray mist. Prolonged or frequently repeated skin-contact 

may cause allergic reactions in some individuals. 

PERSONAL PROTECTIVE EQUIPMENT 

SomE! materials thai are chemical-resistant to this producl are barrier laminate or butyl rubber gloves. If 

you want more options, follow the instructions for category C on an EPA chemical-resistance category 

selection chart. 

All pilots, flaggers, and groundboom applicators must wear: 

• Long-sleeved shirt and long pants and, 

• Shoes plus socks 

All mixers, loaders, other applicators, and other handlers must wear: 

• Long-sleeved shirl and long panls, 

• Shoes plus socks, 

• Chemical resistanl gloves, such as barrier laminate or butyl rubber gloves 

• A NIOSH-approved dusUmisl fillering respirator with any N2

, R, P or HE filter or an NIOSH-approved 

dusUmist filtering respirator with approval number prefix TC-21 C. 

• Chemical-resistant apron when mixing, loading, or cleaning equipment or spills 

Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for washables 

exist, use detergent and hot water. Keep and wa.sh PPE separately from other laundry. 

ENGINEERING CONTROLS STATEMENT 

Pilots must use an enclosed cockpit that meets the requirements, listed in the Worker Protection 

Standard (WPS) for agricultural pesticides [40 CFR 170.240(d)(6)]. 

Flaggers supporting aerial applications must use an enclosed cab that meets the definition in the Worker 

Protection Standard for Agricultural Pesticides 140 CFR 170.240(d)(5)] for dermal protection. In addition, 

flaggers must wear long-sleeved shirt, long pants, shoes, and socks. 

USER SAFETY RECOMMENDATIONS 

Users shoutd: 

• 

• Wash hands thoroughly with soap and water after handling and before eating, drinking, 

chewing gum, using tobacco, or using the toHet. 

• Remove clothing/PPE immediately if pesticide gets inside. Then wash thoroughly and put on 

clean clothing. 

e Remove PPE immediately after handling this product. Wash the outside of gloves before 

removing As soon as possible, wash thoroughly and change ·Into clean cloth·lng. 

ENVIRONMENTAL HAZARDS 

For terrestrial uses, do not appty directly to water, or to areas where surface water is present, or to 

Intertidal areas below the mean high water mark, except as specified on this label for application to rice 

Do not contaminate water when disposing of equipment wash waters. Apply this product only as 

specified on thiS label 

114
STORAGE AND DISPOSAL 

Do not contaminate water, food, or feed by storage or disposal. 

PESTICIDE STORAGE: Store this product in a cool, dry place in its original container only. Container 

should be closed when not in use. Do not expose the product to open flame excessive heat. Store in 

original container and keep closed. 

PESTICtDE DISPOSAL: Pesticide wastes are acutely hazardous. Improper disposal of excess 

i pesticide, spray mixture, or rinsate is a violation of Federal law. tf these wastes cannot be disposed of 

I by use according 10 label instructions, contact your State Pesticide or Environmental Control Agency, or 

the Hazardous Waste representative at the nearest EPA Regional Office for guidance. 

i I CONTAINER DISPOSAL: Triple rinse (or equivalent); then offer for recycling or reconditioning, or 

puncture and dispose of in sanitary landfill, or by other procedures approved by State and local 

authorities. 

DO NOT REUSE EMPTY CONTAINER 

PHYStCAL OR CHEMICAL HAZARDS 

Do not use or store near heat or open flame. 

To Contain a Spilt: Absorb liquid by covering it with cat litter, commercial clay, lime, sand, sawdust, or soda ash. 

Once absorbed, bury the cleaning materiats and cleanse the spill area with a detergent and water solution. 

GENERAL INFORMATION 

THIDIAZURON-DIURON EC is a harvest aid for cotton, used for leaf removal prior to harvest. 

THIDIAZURON-DIURON EC can be applied in most weather conditions, both warm and cool. 

USE PRECAUTIONS' 

This product ',S not to be applied through any type of irrigation system. 

Effecliveness of THIDIAZURON-DtURON EC will be reduced if rainfall occurs within 12 hours post 

application. 

Foliage from treated plants or gin Irash is not to be fed to livestock. 

Rotation to the fottowing crops requires the minimum specified 

application of THIDIAZURON-DIURON EC: 

small grains, sorghum, corn, or root crops (except carrots. onions) 

legumes (including alfal/a) or leafy vegetable (except lettuce) . 

cote crops, garlic, safflower, tomatoes, and watermelon. 

carrots 

onions. 

cantaloupe, honeydew melon/casaba melon, muskmelon, or peppers 

tettuce. when soil has been deep-plowed (12-15 inches). 

OR lettuce when soil is only disced (4-6 inches) 

All other crops. 

periods below after the last 

. two (2) months 

.. two (2) months 

. two (2) months 

.Ihree (3) months 

four (4) months 

.flve (5) months 

. two (2) months 

nine (9) months 

twelve (12) months 

Special Note for inter-cropped grains and legumes planted either as cover crops or planted Into 

treated fields before the minimum two (2) month plant back time after the final THIDtAZURON-DIURON 

EC application. Any such crops are prohibited for use as feed or food and may be used only as cover 

crops. 

Do not use immature crops for food or feed. 

Prevent spray drift from contacting crops other than mature cotton, since this product may 

defoliate or injure other plant species. 

Mixtures 'NIH"": organoprlosphates can Increase nontarget crop phyiotoxlcliy ExerCise additional care 

wiler, lettuce, cl!rUs, cantaiClupes or any other edibie cro;:;s are ad}8cen; to THIDiAZURQhJ-uIURON EC 

t"eai9d cotlon fields 

115
PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL ONTO NONTARGET CROPS 

Under windy weather conditions, applications of THIDIAZURON~DIURON EC may drift to non-target 

crops. 

The following procedures can help reduce the potential for drift: 

.. If wind speeds top ten (10) miles per hour at the apptication site, do not make aerial or ground 

applications of THIDIAZURON-DIURON EC. 

.. Nozzle pressure of 20-30 psi is recommended. 

.. Do not apply this product during a temperature inversion because drift potentiat is high. In addition, 

do not appty this product if the development of a temperature inversion appears likely during the 

application period. 

.. Do not apply this product by ground within 100 feet or by air within 0.5 mile of lettuce. 

RIO GRANDE VALLEY OF TEXAS PROCEDURES TO LOWER SPRAY DRIFT POTENTIAL 

The following procedures can help reduce the potential for drift: 

.. tf wind speeds top ten (10) miles per hour at the application site, do not make aerial or ground 

applications of THtDIAZURON-DIURON EC. If wind sp.eeds are less than ten (10) miles per hour, 

observe local recommendations from your State Extension Cotton Specialist. 

.. Nozzle pressure of 20-30 psi is recommended. 

.. Do not apply this product during a temperature inversion because drift potential is high. In addition, 

do not apply this product if the development of a temperature inversion appears likely during the 

application period. 

.. Use the maximum nozzle orifice size that provides proper coverage and deposition of this product. 

.. CITRUS AREAS: Do not apply this product by ground within 0.5 mile or by air within 5 miles 

downwind of citrus in flush. 

DIRECTIONS FOR USE 

It is a viotation of Federal taw to use this product in a manner inconsistent with its labeling. 

Do not apply this product in a way that will contact workers or other persons, either directty or through 

drift. Only protected handlers may be in the area during application 

116
AGRICULTURAL USE REQUIREMENTS 

Use this product only in accordance with its labeling and with the Worker Protection Standard, 40 CFR 

Part 170. This Standard contains requirements for the protection of agricultural workers On farms, 

forests, nurseries, and greenhouses, and handlers of agricultural pesticides tt contains requirements for 

training, decontamination, notification, and emergency assistance. It also contains specific instructions 

and exceptions pertaining to the statement on this label about personal protective equipment (PPE), and 

restricted-entry interval. The requirements in this box only apply to uses of this product that are covered 

by the Worker Protection Standard. 

Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 12 

hours. 

For minimum early entry PPE use the following: 

PPE required for early entry to treated areas Ihat is permitted under the Worker Protection Standard and 

that involves contact with anything that has been treated, such as plants, soil, or water, is: 

• Coveralls 

• Shoes plus socks 

• Chemical-resistant gloves made of any waterproof material 

• 

SPRAY DRIFT 

Requirements for reducing spray drift for diuron ground and aerial applications: 

Use best practices to avoid drift to all other crops and non-target areas. Do not apply when conditions 

favor drift from target areas. The interaction of many equipment- and weather-related factors determine 

the potential for spray drifL Avoiding spray drift at the application site is the responsibility of the 

applicator. The applicator must follow the most restrictive precartions to avoid drift, inctuding those found 

in this labeling as well as applicable state and local regulations and ordinances. A drift control agent may 

reduce drift, however, it may also decrease weed control. 

Make aerial or ground applications only when the wind speed is less than or equal to 10 miles per hour. 

Do not make aerial or ground applications into temperature inversions. 

Apply with medium or coarser spray (according to ASAE S1andard 572) for standard nozzles. 

Additional requirements for ground apptications: 

When applying to crops, apply w·lth nozzle height no more than 2 feet above the ground or crop canopy. 

When applying to non-crop areas, use lowest nozzle height consistent with safety and efficacy. Direct 

spray into target vegetation. 

Additional requirements for aerial applications: 

The spray boom should be mounted on the aircraft so as to minimize drift caused by wing tip vortices. 

The boom iength must not exceed 75% of the wingspan or 90% of rotor blade diameter. 

Use upwind swath displacement. 

When applYing to crops, do not release spray al a height greaier than 6 to 10 feet above the ground or 

crop canopy. When applying to non-crOp areas, apply at a minimum safe altitude above the area being 

treated. 

Do not apply by air if sensitive non-target crops are within 100 feet of the application site. 

TtME OF APPLICATiON 

TH!DIAZURON-DIURON EC defoliant applications are to be made only 011 mature cotton plants when the· 

uppermosl harvestable boll IS mature. Boll maturity is defined as I} when a boll is squeezed between 

thumb and finger. it does not dent. 2) when cutting a cross section with 8 shaep knife IS difficult; 3) when 

seeds In cross section lack Iiq~lld within the seed coat or outer edges of seed coai are light brown. and 4) 

when fully developed cotyledons a·,-e p~e:,eni 

117
Make appl'lcations of THIDIAZURON-DIURON EC at least 5 days prior to expected harvest date. 

NOTE: Adequate defoliation with THIDIAZURON-DIURON EC depends on three factors: 

• Cotton is actively growing. 

• High retative humidity. 

• Cotton plant teaves are turgid and not desiccated. 

ATTENTION: Desiccation and/or leaf freezing may occur during periods of high temperature when 

adjuvants are added to THtOIAZURON-DIURON EC application solution. Products and adjuvants 

known to cause desiccation of cotton leaf tissue shoutd not be used. 

Under low nighttime temperatures (below 60°F) or othervvise adverse conditions, this product, when used 

alone, may provide less than expected defoliation and / or regrowth·suppression. 

APPLICATtON INFORMATION 

Use an adequate volume of water with the recommended amount of THtDIAZURON-DIURON EC 

defoliant to uniformly and completely cover leaves. For ground equipment, apply 10 - 25 gallon per acre 

and by air, use 2 -10 gallons per acre. Maintain agitation during application. 

DOSAGE INFORMATION 

Application Rate: Before harvest, use 0.4-1.0 pints active ingred·lent/acre (6.4-16 fl. oz.lA). 

One gallon of THIDIAZURON-DIURON EC will treat 8 - 20 acres. Refer to the dose rate table below. 

In some situations, a follow-up application may be needed. THIDtAZURON-DIURON EC may be used for 

this application. Other defoliants may be needed. If additional boll opening is required, Ethephon 6 may 

be used at recommended rates; see product label for rates and timings. Consult your local State 

Extension Cotton Specialist recommendations for rates and timings. 

The maximum annual use rate of THIDIAZURON-DIURON EC is 16 oz. per acre per season 

MIXtNG tNSTRUCTIONS 

1. Filt spray applicator tank with at least one half of the water to be used 

2. Start agitation 

3 Add the appropriate volume of THIDIAZURON -DIU RON EC 

4. Continue agitation and fili tank with the remainder of the water to be used 

5 Agitation shoutd continue throughout the application 

CALlFORNtA ONLY: PRECONDtTtONING 

When used as a pre-conditioner seven to ten days before application of this or other defoliant 

compounds, th·ls product will improve the efficacy of such a defoliant application Before use, observe all 

product label directions, recommendations and prohibitions on both product's labels. 

Application Rate: Use 4-6 fl.oz. of this product/acre in an aerial application of 2-10 gallons of spray 

solution or ground application of 10-25 gallons of spray sotution 

118
APPLICATION RATE TABLE for TH!DJAZURON -DIURON EC 

THJDJAZURON-DJURON EC One Gallon of THJDIAZURON. Active Ingredients per Acre 

Formulated Product DJURON EC Wi!! Treat 

6,4 Qz.lAcre 20 Acres g..,g..:f-5 Ibs. ai/Acre 

(0.4 pUAcce) O. {> 0;-

8.8oz./Acre 15 Acres L g..,...w.lbs. Ai/Acre 

(0.55 ptJAcre) '-' 07 

12.8 oz./Acre 10 Acres O.1Slbs. AI/Acre 

(0.8 ptJAcce) "', I 

16.0 ozJAcre 8 Acres Q..,...ig..7.& Ibs. ai/Acre 

(1.0 ptJAcre) o,n",-

DO NOT APPLY MORE THAN 1.0 PINT OF THJDJAZURON·DJURON EG PER ACRE PER SEASON. 

IMPORTANT CLEAN OUT !NSTRUCTIONS 

When applying THIDIAZURON-DJURON EC, a residue may form in application equipment This residue 

can best be flushed out of the spraying system by using a commercial tank cleaner when done while 

residue is still fresh and moist. DO NOT ALLOW EQUIPMENT TO DRY BEFORE CLEAN OUT. Consul! 

your State Extension Cotton Specialist for recommended tank cleaners and cleaning procedures. 

Use tank cleaner and water immediately after application. Flush the entire system including nozzles. 

booms. application tanks. sumps, pumps. and transfer lines. Allowing the spray solution to dry in the 

application equipment can result in residues that are more difficult to remove. Dried residues are 

extremely difficult to remove. To remove such dried residues, fiJI the affected equipment to 

capacity with commercia! tank cleaner solution and let it remain for 7 days. Afterwards, the 

equipment will need to be thoroughly flushed and rinsed. 

Spray application equipment that has been inadequately cleaned will contain residue of THIDIAZURON -

DIURON EC. Such improper cleaning could lead to crop damage in later applications. 

Arysta UfeScience North America Corporation assumes no !iability due to equipment that has not 

been properly cleaned. 

CONDITIONS OF SALE 

Arysta LifeScience North America Corporation C'Arysta") warrants that thiS product conforms to the 

chemical description on the label and is reasonably fit for the purposes stated on the label only when 

used in accordance with the directions under normal conditions of use. 

2. This warranty does not extend to the use of this product contrary to label instructions. or under 

abnormal use conditions. or under conditions not reasonably foreseeable to Arysta. ARYST A 

D!SCLAIMS ALL OTHER WARRANTIES, EXPRESSED OR IMPLIED, INCLUDING ANY 

WARRANTY OF F!TNESS FOR A PARTICULAR PURPOSE OR MERCHANTAB!L1TY. TO THE 

EXTENT PERM!TTED BY LAW, SELLER SHALL NOT BE LIABLE FOR CONSEQUENTIAL, 

SPECIAL OR !NDIRECT DAMAGES RESULTING FROM OR IN CONNECTION WITH THE 

MANUFACTURE, SALE, DELIVERY, USE, HANDLING OR STORAGE OF THIS PRODUCT. TO 

THE EXTENT PERMITTED BY LAW, SELLER'S LIABILITY SHALL BE LIMITED TO THE REFUND 

OF THE PURCHASE PRICE. ARYSTA DOES NOT AUTHORtZE ANY AGENT OR 

REPRESENTAT!VE TO MAKE ANY OTHER WARRANTY, GUARANTEE OR REPRESENTATION 

CONCERN!NG THIS PRODUCT. 

3. Critical and unforeseeable factors beyond the control of Arysta prevent Arysta from el"lminatlng all 

risks in connection with the use of thiS product. Such risks Include, but are no!·llmiied to. damage to 

plants and crops to which product IS applied, lack of complete con!rol, and damage caused by dnft to 

other plants or cmps. Such risks occur even though the product is reasonably fit for the use stated on 

the label and even though label directions are followed Except as staled In 1 above. to the extent 

perml!(ed by law, by purchasing, accepting and using th:s product, the buyer and user acknowledge 

and assume all risks and liabilities tesulting from handling, storage. and use of to IS product 

119
THIDIAZURON-DIURON EG 

COTTON DEFOLIANT 

For Agricultural Use Only 

/\(: JIVE INGREDtENTS: Thirtiazuron: N-phenyl-N'-1,2,3-thidiazol-5-ylurea· , 

n",r()<1 3-f3.4-dlclllorophenylj--'l, t·dlmethylurea* 

__ t2% 

6% 

82% 

tOO% 

OHler Ingredients: 

TOTAL 

(:",,1'_1111" I II) TtTidiazuron per galion and 0 Sib, Diuron per gallon 

KEEP OUT OF REACH OF CHILDREN 

DANGER - PELIGRO 

::-, USl'2d no enl;ende ta eliqueta, busque a algu'len para que se la exptique a usted 

,," \if!!;"le, 

1,If you do not understand this label, find Someone to explain it to you in detaiL) 

I 

, 

rtf{ 

IF r 

eLO 

IF t; 

1>-1 

irS 

I 

I .'" 

I !I"'" 

! 

T AID 

.j SKIN OR Take off contalllinated cloUTing, 

TI-IING: Rinse skin immediately with plenty of water for t5-20 

minutes 

___ 

M 

__ '_' __ ,,_ Cali a Eoison control center or doctor for treatment advice _ 

EYES Hold eye open and rinse slowly and gently with water for 15· 

20 minutes 

Reillove contact lenses, if present, after the first 5 minutes, 

then continuE' rinSlflg_ 

Call a 20ison control center. or doctor for treatment advice, 

'HALED: Move person to fresh air. 

It person is not breatiTing, call 9 t 1 or an ambulance, Ihen 

give artificial respiration, preferably mouth-to-mouth is 

possible. 

Call a eoison control center or doclo! for treatment advice_ 

NALLOWED: Immediately call a poison control center or doctor for 

treatment adv'lce 

Do not induce vomiting unless told to do so by OJ poison 

control center or doctor_ 

rtave person sip a glass or water If able to swallow 

• Do not give anything by mouth to an unconscious Q€rson . 

'E"'TO--PHYSIClAN:'Probable mucosal damage may contraindicate the use of 

'rir. bV<loe. 

---------.-"----------.::iCiT LINE NUMBER 

p d'-;;:-t1ro'dllct co'ntalner or label with you when calling a poison control center I 1-1" 

I l'T 

, 

-- :-,0<:101' or going for treatment. 

: eM 

I 

! 

ERGENCY NUMBERS: 

Transportation or spill, catt CHEMTREC 800-424-9300. 

An.ilna!...i:.eatth, 8_66-303-6952 

101,,,,,,,, 11",(',11>""".1)"""" P'U.T)·RI:I)(12!)5U7) 

PRECAUTIONARY STATEMENTS 

HAZARDS TO HUMANS AND DOMESTIC ANtMALS 

DANGER 

Corrosive, Causes irreversible eye damage. Causes burns. H

get in eyes, on skin, or on clothing_ Avoid breathing dust or sp

frequently repeated skin-contact may cause allergic reactions 

ENVIRONMENTAL,. HAZARDS 

For terrestrial uses, do not apply directly to water, or to ar

present. or to intertidal areas below the mean high water mark

label for application to rice. Do not contaminate water when d

waters. Apply this product only as specified on this label. 

STORAGE AND DISPOSAL 

Do not contaminate water, food, or feed by storage or dispos

PESTtCtDE STORAGE; Store this product in a cool, dry plac

only_ Container should be closed when not in use, Do not ex

flame excessive heat. Store in original container and keep cl

PESTtCtDE DtSPOSAL Pesticide wastes are acutely hazar

of excess pesticide, spray mixture. or rinsate is a violation of 

wastes caQnot be disposed of by use according to label instr

Pesticide or Environmental Control Agency, or tr,e Hazardou

the nearest EPA Regional Office for guidance, 

CONTAINER DtSPOSAL: Triple rinse (or equivalent); then o

reconditioning, or puncture and dispose of in sanitary landfill

approved by State and local authorities. 

DO NOT REUSE EMPTY CONTAINER 

PHYStCAL OR CHEMICAL HAZARDS 

Do not use or store near heat or open fiame_ 

To Contain a Spil t; Absorb liquid by covering it with cat litter

sand, sawdust, or soda ash_ Once absorbed, bury the cleanin

spill area with a detergent and water solution_ 

DtRECTlONS FOR USE 

It is a viotation of Federat law to use this product in a m

labeting. 

SEE ATTACHED BOOKLET FOR ADDITIONAL 

AND USE DIRECTIONS 

EPA Reg. No. 66330-333 EPA Est. No. 51036-GA.(l01 

ADxxxxxx 

NET CONTENTS: 

BASE LABEL 

Page 8 

Manufactured for 

Arysta UfeScience 

15401 Weston Park

Cary, NC 27513 
July 13, 2007 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF 

PREVENTION, PESTICIDES 

AND TOXIC SUBSTANCES 

MEMORANDUM: 

Subject: 

From: 

Through: 

To: 

DiuronRED 

Thidiazuron-Diuron EC Cotton Defoliant 

EPA Reg. No.: 66330-333 

Re: PRE Preliminary Label Assessment 

Judy Loranger ~ -i..D~ e-J 

Product Reregistration Branch 

Special Review and Reregistration Division (7508P) 

Lawrence Schnaubelt .("*"'- g~';:f2~? Product Reregistration Branch 

Special Review and Reregistration Division (7508P) 

Joanne Miller, Product Manager 23 

Herbicide Branch 

Registration Division (7505P) 

121
SCOPE: The primary purpose of this preliminary label assessment is to determine 

whether or not the draft labels submitted in connection with product reregistration 

comply with amended labeling language specified in Chapter V of the subject 

REDIIRED. Product-specific data (product chemistry, acute toxicity, and in some cases 

efficacy data) were also required to be submitted or cited to support product 

reregistration. PRB's reviews of these data are appended to this assessment and may 

require additional revisions to the product label. 

BACKGROUND: The registrant has submitted 5 copies of draft labeling for the subject 

product in its 8-month response to the REDIIRED. PRB has completed a preliminary 

assessment of the draft labeling. A copy of this assessment may be accessed 

electronically on the LAN through the Q-Drive. The path is q:lprbllabeII066330/333. 

Note: In addition to the information presented in this preliminary label assessment, 

Product ManagerlLabel Reviewers must apply their own knowledge ofthe subject 

product and the product's regulatory history (including comparison with existing stamped 

accepted labeling) to conduct a final review of the proposed labeL It is the responsibility 

of the PM to obtain the necessary label improvements required for final product 

reregistration. 

Please note that this product contains multiple active ingredients. Additionallabel 

reviews will be necessary when the RED is issued for the other active ingredient 

(Thidiazuron.) 

PRB reconunends that the PMs continue to follow the guidance provided in the Label 

Review Manual, including formatting suggestions presented in the sample labels in 

Chapter 3, to improve the quality and consistency of product labels. 

RECOMMENDATIONS: 

The subject product requires revisions to conform with the RED and acute toxicity 

review. Deficiencies are listed in the table below. Once these revisions have been 

submitted and approved by the PM, the PM may issue an amended registration. Since 

this product contains multiple active ingredients it may not be reregistered until a 

favorable registration eligibility decision is made for all active ingredients. At that time 

the more restrictive language must be adopted for the labeL 

2 

122
Appendix I 

PRB Label Analysis For Compliance With Label Revisions Specified In the 

REDIIRED and/or Technical Reviews 

Label Requirement Acceptable Not Acceptable Comments 

Restricted Use Pesticide Per the acute toxicity review, this 

product meets the criterion for restricted 

use classification based on data that 

place it in toxicity category I for eye 

irritation. 

Ingredients Statement X 

Signal Word X 

First Aid X Based on toxicity ranking noted in the 

acute toxicity review, PRB recommends 

that the First Aid statements be placed 

on the label in the following order: 

"IF IN EYES ... 

IF ON SKIN OR CLOTHING ... 

IF INHALED ... 

IF SWALLOWED.,. " 

Emergency Information X 

Note to Physician X PRB recommends that the Note to 

Physician be revised to address eye 

irritation concerns. 

Hazards to Humans and X Per the acute toxicity review, the 

Domestic Animals Hazards to Humans and Domestic 

Animals must be revised to read: 

"DANGER 

Corrosive. Causes irreversible eye 

damage. Causes skin irritation. Do not 

get in eyes, on skin, or on clothing." 

PPE X Per the acute toxicity review and the 

Diuron RED, and Page 10-l6 of the label 

review manual, the PPE section must be 

revised to read: 

"Some materials that are chemicalresistant to this product are made of 

barrier laminate or butyl rubber. If you 

want more options, follow the 

instructions for category C on an EPA 

chemical-resistance selection chart. 

All pilots and flaggers must wear: 

Long-sleeved shirt and long pants, 

Shoes and socks. 

All mixers, loaders, other applicators and 

other handlers must wear: 

3 

123
Label Requirement Acceptable Not Acceptable Comments 

Coveralls over short~sleeved shirt and 

short pants, 

Socks plus chemical~resistant footwear, 

Chemical~resistant gloves, 

Goggles, face sbield or safety glasses, 

Chemical~resistant apron when mixing, 

loading or cleaning equipment or spills, 

,nd 

Chemical-resistant headgear for 

overhead exposure. 

In addition to the PPE above, all 

handlers except for ground boom 

applicators, pilots and flaggers must also 

wear a NIOSH~approved dust/mist 

filtering respirator with any N, R, P of 

HE filter or a NIOSH-approved 

dust/mist filtering respirator with 

approval number TC-2IC." 

Note to PM: 

The PPE specified in the RED has been 

revised as required in the acute toxicity 

review and the label review manual to 

require double layer PPE plus eyewear 

for aU handlers including ground boom 

applicators. 

Engineering Controls X 

User Safety X Because coveralls are required for some 

Requirements handlers PRB recommends that the 

following text be added to the User 

Safety Requirements: 

"Discard clothing and other absorbent 

materials that have been drenched or 

heavily contaminated with this product's 

concentrate. Do not reuse them." 

User Safety X 

Recommendations 

Environmental Hazards X The phrase "For terrestrial Use" 

erroneously appearing on Page 5 of the 

Diuron RED label table and also on the 

label is confusing and should be deleted 

from the label. 

Physical and Chemical X 

Hazards 

WPS text X 

Non-WPS text NlA 

Storage and Disposal X 

~ay Drift Labeling X 

General Precautions and X 

Restrictions 

Application Instructions Per Page 12 of the Diuron RED, the 

following text was required for use on 

4 

124
Label Requirement Acceptable Not Acceptable Comments 

cotton: 

"Apply a maximum of three applications 

per year." 

Minimum retreatment interval is 21 

days." 

Note to PM: PRE is uncertain whether 

these restrictions are appropriate/needed 

for this pre-harvest defoliant use and 

defers to RD re.garding this issue. 

Other Comments NiA 

5 

125
UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

Subject: 

From: 

To: 

Applicunt: 

FI~bruary 21, 2007 

EPA Reg. No.: 66330-33!Thidiazuron~Diurol1 EC 

DP Barcode: 336474 

Case No.: 004(1 

,,~\ 

lvlarianne Lewis, Biologist " , . , , Product Reregistration Branch j < •• l \ i lL')~"'- 1--' ' ... , 

Special Review and Reregistration Division (7508e) 

Barbara Briscoe, CRM 

Product Reregistration Branch 

$pecial Review and Reregistration Division (7508C) 

Arysta LifeScicnce North America Corp. 

15401 Weston Parkway, Suite 150 

Cary, NC 27513 

FORMULATION FROM EPA Reg. No. 66330·33 LABEL: 

Ac,:Jive Ingredien!(s): 

Diuron . < ••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••••• 

Thidiazuron .................. . 

Jnert lngredient(s): . 

Total 

OFFICE OF 

PREVENTION, PESTICIDES 

AND TOXIC SUI)STANCES 

6.0% 

12.0% 

_82.0~'{) 

100.0% 

126
BACKORQllND: In the 8 month re:.pOllse to the Diuron RED, the registrant has submitted acute 

toxicity studies to support the reregistration of their product, EPA Reg. No. 66330-33. The 

MRlD's are as [oHows: 468773-03 (81-1),468773-04 (81-2), 468773-05 (81-3), 468773-06 (81-

4), 468773-07 (81-5), 468773-08 (81-6). The studies were conducted by Product Safety Labs. 

The test material used in each of the studies was the subject product. 

The primary eye ilTit3tion study (81-4) is self validated as Toxicity Category I therefore a fuli 

review of this study wiiJ Hot be conducted at this time by the Agency. 

" Five (8 I-I, 81-2, 8 j -3, 81-5, 81-6) of the acute toxicity studi~s submitted are acceptable to 

suppori the reregistration of EPA R~~g. No. 66330-33. 

{t The primary eye in'itation study (81-4) is self validated as Toxicity Category L 

The acute toxicity profile for EPA Reg. No. 66330-33 is currently: 

Acote On:! 

Acute I)ermal 

Aeutc Inhal8tion 

Pri mary Eye 

Primal',';' Dennal 

Skin Sensitization 

IV 

IV 

)V 

11 

Hon sensitizer 

Accept,'lbie 

Acceptable 

Acc~ptable 

SclfValidated 

Acceptable 

Acceptable 

NOTE: Tile acute tl.lxicity requirements have been satisficd for the subject product. 

127
DATA REVIEW FOR ACUTE ORAL TOXICITY (§8!-1, 870.!lOO) 

Product lVlanager: Jim Tompkins, 25 Reviewer: Marianne Lc\vis 

MRID No.: 468773-03 Study Completion Date: 511 5/06 

Report No.: 19086 

Testing Facility: Product Safety Labs 

Author: G. Moore 

Quality Assurance (40 CFR ~160.12): Included 

Test Material: Thidiazuron-Diuron Ee, amber liquid 

Species: SpragueMDawley derived albino rat 

Age: young adult 

Weight', females::::: 194 -- 233 

Source: Ace Animals, Inc. 

Conclusion: Up & Down Method 

1. LDso (mg/kg): > 5000 Jnr/kg 

2. Toxicity Category: lV Classification: Acceptable 

Procedure- (Deviations from §81~1): none 

Results: 

.. 

Animalld Dose Level Short tem1 

(mg/kg) outcome 

._----

8256 5000 S ---'--' 8282 5000 S ._-

8283 5000 S .. 

Long tenn 

outcome 

S 

S 

S 

Observations: 3/3 piloerection, li3 hypoactive, 113 ano-genital staining, all active and healthy 

from day 3 to end of study. 

Gross Necropsy: No observabie abnonnalities noted 

-

128
DATA REVIEW FOR ACUTE DERMAL TOX1ClTY (§81-2, 870.1100) 

Product ]\tlanager: Jim Tompkins, 25 

MRlD No.: 468773-04 

Testing Facility: Product Safety Labs 

Authow: G. Moore 

Quality Assurance (40 CFR §160.12): Included 

Reviewer: Marianne Lewis 

Study Completion Date: 5115/06 

Report No.: 19087 

Test IVlatcria!: Thidiazuron-Diuron Ee, amber liquid 

Species: Sprague-Dawley derived albino rat 

Weight: males ~~ 328 - 343 g; females = 218 - 230 g 

Age: young adult 

Sour'C\i; ACe Animals, lnc. 

Summary: 

1. LD5() (mglkg): > 5000 llIg1kg 

2. Tnxki!y Categury: IV Classification: Acceptable 

Procedure (Dcvi'Htions From §8J-2): none 

Results; 

IF 

Reported Mortathy "~-~--~~--~~~~~~~~-.~~~~~~~~ I (number deaths/number tested) 

DOSAGE (mg!kg) 

-L_~es 

~ 

Females Combined 

5000 . --~+I=-~~~~O~/~5~~~~~~~0~15-=~~9-~~~O~/~IO~~~~ 

Observations: Twenty four hours prior to application of the test material the dorsal area and 

tnmki; were clipped free of hair. The neat test lO<lterial was applied evenly over a dose area of 

approx. 2 x 3 inches (approx. 10%, of total body surface) and covered with 2 x 3 inch 4-ply gauze 

pad. Th~ pads and trunks were wrapped with a 3 inch Durapore tape. After 24 hours, the wraps 

and pads were removed and the test sites were gently cleansed. 

1 Oil 0 exhibited erythema &" edema, 7/10 desquamation (lasting throughout the study) - apart from 

these signs all appeared active and healthy for the duration of the study. 

Gross Necropsy Findings: No observable abnonnalities were noted. 

129
DATA REVIEW FOR ACUTE INHALATION TOXICITY TESTING (§81-3, 870.1300) 

Product Manager: Jim Tompkins, 25 

MRID No.: 468773-05 

Reviewer: Marianne Lewis 

Study Completion Date; 51] S!06 

Report No.: 19088 

Testing Facility: Product Safety Labs 

Author: O. Moore 

Quality Assurance (40 CFR §160.12): Included 

Test Material: Thidiazurou-Diuron Ee, amber liquid 

Species: Sprague-Dawley derived albino rat 

\Veight: males = 316 - 326 g; females = 209 - 244 g 

Age: young adult 

Source: Ace Animals, Inc. 

Summary: 

1. LCSII (mg/L): > 2.01 mg/L 

2, MMAD: 3.0 I-Lm GSD: 1.75 

3, Tox, Category: ,IV Classification: Acceptable 

Proc£di1r€ (Deviation From §81-3): none 

Results: Reported Mortality 

r-EXp~-SUfe-- l--- number deaths/number tested) 

I Concentr~ion_ Males ____ .Fema_les -f_-oo-mblned 

1-- __ 0 52..'.'.'l¥i·3 0/5"--__ ~ _ 

1 __ "2,,,.01 rng/l 2/5 j __ 1/5 ~3"-1 .. IO",-__ --, 

----~--

Chamber Atmosphere 

~~b-evel nw/L MMAD +--- GSD -- 0.52 2.8 11m 1.75 

2.9 ~m 1.75 --- 2.01 2.9 ~m 1.72 

3.0 ~111 1.75 -

130
- -----;;-

Chamber Dose Level m.g/L Dose Level mgl~ 

Environment O.S? 2.01 ------,-~, - Chamber Volume 150 L ISO L - Airflow 45.7 45.7 

T f'C) 21 - 22 ? 1 - ,,) i emDeraturc \ - --~-

Relative HUl11i~ % 42 - 68 ~2 -7~ -:::j 

Clinical Observations: 

iD(?sc mgll. I Tim'~-~)fDeath Clinical Observations -.~--- J ~52_J ____ N_I_~___ ~~~l\~egf~~:~ r~~~i~at~O;~:~f:~~~; hwoacti~'e, all active and I 

I 2.01 I 3/] 0 on day 2 Reduced fecal volume, hunched posture, hypo activity, irregular l I I respiration, moist rales, facial staining, red ocular discharge, 6/10 d I 

L_. _____ ,._"._L ____ ~~;s_'_fu_'_:t~~~~Lo_rS_)_IO_s_t_w_e_ight during first half O_f_st_U_d_Y,_-_a_I_1 _ga_in_e_d b_y_en_d_. 

Gross Necmpsy Findings: 

~EQ~~~~lg/L_I Gr~~.~ Necropsy Observations . 

1-- O.5~o observable abnOimalities noted. 

--2~(il I ~~'~cden1.s: lungs slight edema, red intestines; survivors: no observable 

. __ ~ __ .....L abno"nTI=al"it"ie"'sc,I"'10"t"cd"--_____________________ _ 

131
DATA REVIEW FOR SKIN IRRITATION TESTING (§81-5, 870.2500) 

Product Manager: Jim Tompkins, 25 

MRID No.: 468773-07 

Testing Facility: Product Safety Labs 

Author: G. Moore 

Quality Assurance (40 CFR §160.12): Included 

Reviewer: Marianne Lewis 

Study Completion Date: 5115106 

Report No.: 19090 

Test Material: Thidiazuron~Diuron Ee, amber liquid 

Dosage: 

Species: 

Age: 

Sex: 

Weight: 

Source: 

Smnmary: 

0.5 mL 

New Zealand albino rabbit 

young adult 

3 males 

not given 

Robinson Services, Inc. 

1. Toxidty Category: II 

2. Classification: Acceptable 

Prm;~dure (Deviations From §81-S): none 

PI! = 3.8 

Results: Twenty four hours prior to application ofihe test material the dorsal area and trunks 

were dipped free of hair. The test material was applied to one 6 cm~ intact dose site and covered 

with a I x I inch 4-ply gauze pad and wrapped with 3 inch Micropore tape. After 4 hours the 

pnds and wrappings were removed and the test sites were cleansed. 

At I hr., 113 very slight erythema, 2/3 well defined erythema, & 3/3 very slight edema. From 24 

to 48 hrs., 2/3 well defined erythema, 1/3 moderate to severe erythema, & 3/3 slight edema. At 72 

hrs., 3/3 well defined erythema, 3/3 slight edema, & 2/3 hyperkeratosis. On day 7,313 very slight 

erythema, 3/3 very slight edema, & 3/3 desquamation. On day 10,3/3 velY slight erythema, 2/3 

very slight edema, & 3/3 desquamation. By day 14, 3/3 very slight erythema & desquamation. 

132
DAT:" REVIEW FOR DERMAL SENSiTiZATiON TESTING (§81-6, 870.2600) 

Product Manager: Jim Tompkins, 25 

MRlD No.: 468773-08 

Testing Facility: Product Safety Labs 

Author: G. Moore 

Quality Assurance (40 eFR §160.12): Included 

Reviewer: Marianne Lewis 

Study Completion Date: 5/15/06 

Report No.: 19091 

Test Material: Thidiazuron-Diuron EC, amber liquid 

Positive Control Material: HCA historical control (PSL # 18271, 10-14-05) 

Spedes: Hartley albino guinea pig 

vVeight: males"" 297 -- 380 g 

Age: young adult 

Source: Elm Hill Breeding Labs 

Method: Buchler 

Summary: 

1. This Product is a non sensitizer 

2. Classification: Acceptable 

Procedure (Deviation From §81-6): none 

Procedu.rc: 

A group of animals were used to detennine the highest non-irritating concentration (HNIC) of the 

test subr,<,.ance prior to the challenge dose. The HNlC for the test substance was detennined to be 

6% w/w mixture in mineral oil. 

The test animals were induced with 0.4 !TIl of 75% test material in mineral oil once a week for 

three weeks using a Hill Top Chamber. Twenty four hours after each induction dose the animals 

were scored for irritation. Two weeks after the last iIlduction dose, 0.4 ml of6% w/w of test 

material in mineral oil was used to challcnge the test animals. Twenty four and 48 hours after the 

challenge the animals were evaluated for sensitization. 

A group often animals were used as naive controls. These animals received only the challenge 

doses of the tcst material. 

133
Results: Due to initation and residue adhesi\'e from the tape the test sites were moved for the 

second and third induction doses. 

Twenty four hours after the first induction dose for the test material-induced animals, 5/20 

exhibited very faint erythema and 12/20 faint erythema. After the second induction dose, 10/20 

exhibited very faint erythema and 6/20 faint el)1:hema. After the third induction dose, 8/20 

exhibited very faint erythema, 9/20 faint erythema, and 1120 well defined erythema at the test site. 

Twenty four hours after challenge, 8/20 test material-induced animals exhibited very faint 

erythema. 

At 24 hours, in the naive control group of animals challenged with the test material, 4/10 

exhibited very faint erythema. 

134
ACUTE TaX ONE-LINER 

I. PC CODE: 035505 

2. CURRENT DATE: February 21, 2007 

3. TEST MATERIAL Thidiazuron-Diuron EC, amber liquid 

Diuron: 6.0%, Thidiazuron: 12.0% 

Ii S 1 - . / I tliC y/Speclcs MRllJ # 

I Lab/Study#!Date 

! acu,te oral toxicity/rau,product 46877303 

I Salety Labsll 9086/5-15-06 

! acute deonal t~xicitY/rat! 46877304 

Product Safety Labs1l9087! 

5-15-06 

II--

1 acute inhalation ioxicitylfatl 46877305 I Product Safety LabslI 90881 

, 5-15-06 

I~~ry eY~-iITitation/rabbit! 46877306 

~(()duct Satety Labs!! 9089! 

5 .. )5-06 

I primary dermal irritation/rabbit! 46877307 

Product Safety Labs/190901 1 

~ 5··15-06 

II 

I 

I 

, 

I skin sensitization/h'liinea pig! 46877308 

Product Safety Labs! 19091 i 

I, 5-15-06 .. 

-I' ;;x~1 Core 1 ~attGrade ~I 

Results I 

LD" > 5000 mg/kg I ! V A l! 

---1-

LD," > 5000 mg/kg I ~-"1-t--11 I' 

-

LD;u> 2.01 mgiL I 

MMAD ~ 3.0 ~m: GSD ~ U5 

--- ---~ V I A ~ I :1 -. _ ...... --t--l------ll --.. - At 1 hr., 113 very slight erythema, 2/3 

' t 1 , V I 

I +--t--"--II I 

I r 

well defined erythema, & 3/3 very slight ! 

1 I Ai 

I I 

edema. From 24 to 48 hrs., 2/3 well 

defined erythema, 113 moderate to 

severe erythema, & 3/3 slight edema. 

At 72 hrs., 3/3 well defined erythema, 

3/3 slight edema, & 2/3 hyperkeratosis. 

On day 7, 3/3 very slight erythema, 3/3 

very slight edema. 3/3 desquamation. 

On day 10, 3!3 very slight erythema, 2/3 

very slight edema, 3/3 desquamation. 

By day 14, 3/3 very slight erythema & 

desquamation. 

Non sensitizer 

.. -

I 

I 

-

i 

I' 

I 

I 

'I 

II 

I 

~-1 

I .II ~ .. Core (rrade l .... ey:A "" Acceptable, S = Supplementary,U = Unacceptable,V 0= self-Validated 

135
lABELING: 

!D #: 066330-00033 THIDIAZURON-DIURON EC 

RESTRICTED USE CLASSIFICA nON RECOMMENDED: 

Due to primary eye irritation toxicity category. 

SIGNAL WORD: DANGER PELIGRO 

HAZARDS TO HUMANS AND DOMESTIC ANIMALS: 

COITosive. Causes ilTcversible eye damage. Causc3 skin in'itation. Do nol get ill eyes, on 

skin, or on clothing. Wear protective eyewcar (goggles, face shield, or safety glasses), 

coveralls over Sh011 sleeved shirt a!\d short pants, chemical resistant shoes, socks, and 

chemical resistant gloves (barrier iamillate or butyl rubber, selection category B). 

FIRST AID: 

IF IN EYES: Hold eye open and rinse slowly and gentiy with water fOr J S~20 minutes. 

Remove contact lenses, ifprest:lIt, after the first 5 mirmtts, then continue rinsir;f eye. Call 

a poison control center or doctor fi:H treatment advicc. 

IF ON SKIN OR CLOTHING: Take off contmnirlated clolhing. Rillse skin irruTI.ediately 

with plenty of water for) 5-20 minut~s. Call a poison control cenier or doctor for 

treatment advice. 

Have the product colltaine( or label with you when calli!lg a poison control center or 

doctor or going for treatment. You may also contact 1-800-xxx-xxxx for emergency 

medical treatment inlormation. 

lISERSAFETY RECOMMENDATIONS: 

User should wash hands before eating, drinking, chewing gUlli, using tobacco. or u~ing the 

toi I et. 

User shollld remove clothing/PPE immediately tfpesticide gets inside. Then lVash 

thoroughly and put on dean dothing . 

. Users should remove prE immediately Hfter handling this product. Wash thc outsid~ of 

gloves before removing. As soon as possible, ' .. vash thoroughly and change ~nto clear, 

clothing. 

The proposed label must contain the following guidance: 

136
NOTE TO PHYSICIAN: 

Probable mucosal damage may contraindicate the use of gastric lavage. 

----------------------

Notc to CRM/PJVflRegistrant: 

The proposed label should contain a Note to Physician which addresses the primary ~ye irritation 

Toxicity Category \. The following statements are some suggested types of illfonnation that could 

be included, if applicable, in the Note to Physicians; 

- technical in(ormmion on symptomatology; 

.. use of supportive treatments to maintain life functions~ 

- medicine that will counteract the specific physiological effects of the pesticide; 

- company telephone ilumber to specific medica! personnel who can provide 

speciaiized medical advice. 

137
DATE OUT: 17/MAY/07 

SUBJECT: PRODUCT CHEMISTRY REVIEW OF: TGAI II: MUP II: EUP Ixl 

BARCODE NO.: 339926 REG.IFILE SYMBOL NO.: 66330-333 

PRODUCT NAME: Thidiazuron-Diuron EC 

COMPANY NAME: Arysta LifeScience North America Com. 

FROM: Maria Rivera Piansay, Chemist t\4..l~\, 

h.l' ~C~~1 . Product Chemistry Team 1: \ 

PRBISRRD (7508C) 

TO: Barbara Briscoe, CRM 

Product Reregistration Branch 

Special Review and Reregistration Division (7508C) 

INTRODUCTION: 

ACTION CODE: 675 

In response to our review of 5/1/07, Arysta LifeScience North America Corporation submitted revised basic and 

alternate formulation Confidential Statements ofFonnula (CSFs), both dated 5/8/07, in support of the reregistration of 

Thidiazuron-Diuron Ee, EPA Reg. No. 66330-333. 

FINDINGS: 

1. Previously, the registrant was requested to clarifY the inconsistency between the basic and the alternate 

CSF in declaring the purity of the The basic CSF declared 

while the alternate claimed The registrant responded by submitting revised CSFs showing 

a different Diuron source. According to the current CSFs, the technical Diuron currently used in 

fonnulating this product is now , with a purity of 

With this revision, the CSFs are now found acceptable to support this product. The nominal 

concentrations of the active ingredients agree with that on the label, meeting PR Notice 91-2. The 

certified limits on the active and inert ingredients are acceptable as per 40 CFR 158.175(b)(2). All 

ingredients listed on the CSFs are cleared for use in pesticide fonnulations. 

2. The Ingredients statements are in compliance with the requirements of 40 CFR 156.1 O(g). The 

Physical or Chemical Hazards subheading is not triggered based on the physical/chemical 

characteristics of the product. The Storage and Disposal section of the label is acceptable in 

accordance with 40 CFR 156.10 (i)(2)(ix). 

CONCLUSIONS: 

The registrant has now satisfied product chemistry data requirements for the reregistration of EPA Reg. No. 

66330-333, 

M.R. pjansay and Cenlfal File (EPA Reg. No. 66330-333) 

7508C:SRRD:PRB:CM-2: M.R.P.: (171MA YI07):703-308-8063:<66330-333> 

138

*Product ingredient source information may be entitled to confidential treatment*
DATE OUT: OI/MAY/07 

SUBJECT: PRODUCT CHEMISTRY REVIEW OF: TGAI [I; MUP [I; EUP [xl 

BARCODE NO.: 336741 REGJFILE SYMBOL NO.: 66330-333 

PRODUCT NAME: Thidiazuron-Diuron EC MRID NOS.: 46?364-01, 462364-03, 462364-04 

COMPANY NAME: Arysta LifeScience North America Corp. ACTION CODE: 674 

r 

FROM: Maria Rivera Piansay, Chemist f.~~ J ,,--,,!~ Product Chemistry Team l U 

PRB/SRRD (7508C) 

TO: Barbara Briscoe, CRM 

Product Reregistration Branch 

Special Review and Reregistration Division (7508C) 

INTRODUCTION: 

A Reregistration Eligibility Decision (RED), Case number 0046, was issued in September, 2003 for the Technical 

Grade Active Ingredient (TGAI) Diuron. According to the RED, the generic data base supporting the reregistration of 

Diuron have been reviewed and found to be substantially complete. 

In the 8-month response to the Diuron RED, Arysta LifeScience North America Corporation submitted a basic and an 

alternate formulation Confidential Statement of Formula (CSF), dated 2/5/07; a draft label, EPA received 2/S/07; and 

product chemistry data in MRJD numbers462364-0 1,462364-03 and 462364-04. The registrant is requesting FIFRA 

Section 4 reregistration ofThidiazuron-Diuron EC, EPA Reg. No. 66330-333. 

FINDINGS: 

1. EPA Reg. No. 66330-333 is an end-use product that contains Diuron and Thidiazuron froln registered 

sources (EPA Reg. No. 66330-324 and respectively) at label claim nominal concentrations of 

6.0% and 12.0%, respectively. 

2. The CSFs for the basic and the alternate formulations are not acceptable at this time because of an 

inconsistency in the purity of the The basic CSF declares 

while the alternate claims The registrant must clarify this discrepancy. 

3. The product chemistry data presented in MRID numbers 462364-0 1,462364-03, and 462364-04 

are adequate and satisfy the product chemistry data requirements under Subgroups A and B 

which pertain to Product Identity, Composition and Analysis, and Physical and Chemical 

Properties, respectively. 

4. The Ingredients statements are in compliance with the requirelnents of 40 CFR I56.10(g). The 

Physical or Chemical Hazards subheading is not triggered based on the physical/chemical 

characteristics of the product. The Storage and Disposal section of the label is acceptable in 

accordance with 40 CFR 156.10 (i)(2)(ix). 

CONCLUSIONS: Except for Finding 2, the registrant has satisfied product chemistry data requirements 

for the reregistration of EPA Reg. No. 66330-333. 

THIS REVIEW CONTAINS FIFRA CBl 

139

*Product ingredient source information may be entitled to confidential treatment*
2 

REVIEW OF PRODUCT CHEMISTRY DATA: 

PRODUCT NAME: Thidiazuron-Diuron EC EPA Reg. No: 66330-333 

Group A: Series 830-Product Identity, Composition, and Analysis (40 CFR158.I55, .160, .165, .167, 

.170, .175 & .180). 

830-1550 Product Identitv and Composition 

EPA Reg. No. 66330-333 is an end-use product produced through a non-integrated 

formulation system. The active ingredients Diuron and Thidiazuron are claimed in the label at 6.0% and 

12.0%, respectively. Description of materials used in the formulation of this product is found in MRID 

number 459373-01 and on the eSF. 

830-1600 Description of Materials Used to Produce the Product 

Refer to Confidential Appendix A. 

830-1620 Discussion of Formulation Process 

Refer to Confidential Appendix A. 

830-1670 Discussion of Formation of Impurities 

Refer to Confidential Appendix A. 

830-1700 Preliminary Analysis 

Refer to Confidential App~ndix A 

830-1750 Certified Limits 

Refer to Confidential Appendix A. 

830-1800 Enforcement of Analytical Method 

The registrant cited a validated analytical method for the analyis of Diuron and Thidiazuron (MRID 

number 468773-02). The active ingredients are extracted from the fonnulated product using methanol, and 

analyzed by HPLC with detection by UVNis absorption. 

This analytical method had been previously reviewed and accepted and determined to satisfy GRN 

830.1800. 

THIS REVIEW CONTAINS FIFRA CBl 

140
3 

Product Chemistry Data 

Subgroup A: Series 830.1550 - 830.1800 (40 CFR IS8.1S5 - 158.180) 

GUIDELiNE REFERENCE NO. MRIDNumber Data 

(GRN)/ TITLE 830 Fulfilled 

. 1550 Product Identity and COI!1position 462364-04 . Y 

.1600 Description of Materials Used to 462364-04 Y 

Produce the Product 

.1620 Description of Formulation Process 462364-04 Y 

.1650 Discussion of Formation of 462364-04 Y 

Impurities 

.1700 Preliminary Analysis N/A N/A 

.1750 Certified Limits 462364-04 and CSF Y 

.1800 Enforcement Analytical Method 462364-04 y 

Subgroup B: Series 830.6302 -7950 (40 CFR 158.190) 

GUIDELINE REFERENCE VALUE OR 

NO. QUALITATIVE MRID Data Fulfilled 

(GRN)/ TITLE 830 DESCRIPTION Number 

.6302 Color Amber 468773-01 Y 

.6303 Physical State Liquid at 25°C 462364-01, -03 Y 

.6304 Odor Amine 468773-01 y 

.6314 Oxidation/Reduction: Chemically stable to the action 462364-01, -03 Y 

Chemical Incompatibility of water, Iron powder, and 

Monoammonium phosphate 

The test material underwent a 

mild oxidation reaction in the 

presence of a potassium 

pennanganate solution. 

.6315 Flammability/Flame Y 

Extension >93°C 462364-0 I, -03 

.6316 Explodability N/A N/A 

462364-01, -03 

141
4 

.6317 Storage Stability Post-storage (duplicate) 

analyses of the product (one- 468773-02 y 

year, room-temperature 

storage) yielded Diuron results 

ranging from 5.92 to 6.18% 

with an average of 6.02%. 

Thidiazuron results ranged 

from 11.83 to 12.12% with an 

average of 11.96%. 

.6318 Viscosity 70 mpas@ 25°C 462364-01 Y 

64 mpas @ 25°C 462364-03 

.6320 Corrosion Corrosion testing was 468773-02 Y 

Characteristics conducted in combination with 

the Storage Stability testing. 

Product container (HDPE) 

retained its original condition 

after one year of storage at 

room temperature. 

.6321 Dielectric Breakdown N/A --- N/A 

Voltage 

.7000 pH 5.60 @ 25"C 462364-01 Y 

5.46 @25"C 462364-03 

.7300 Density/Relative 

Density/Bulk Density 0.9935 g/mL @ 25"C 462364-01 Y 

0.9938 g/mL (aJ 25"C 462364-03 

Explanations; Y = Requirement fulfilled; N = Requirement not fulfilled; N/A = Not applicable; G = Data gap 

THIS REVIEW CONTAINS FIFRA CBl 

142
Confidential Appendix A 

830-1750 Certified Limits 

Diuron: Lower Limit: 5.7%; Nomina! Conc.: 6.0%; Upper Limit: 6.3% 

Thidiazuron: Lower Limit: 11.4%; Nominal Conc.: 12.0%; Upper Limit: 12.6% 

M.R. J'iansay ilnd Central File (EPA Reg. No. 66330-333) 

7508C:SRRJ):I'RB:CM·2: M.R.P.: (0 liMA YI07}:703-308-8063:<66330-333> 

THIS REVIEW CONTAINS FIFRA CBI 

143

*Manufacturing process information may be entitled to confidential treatment*
Pages 144-147 - *Confidential Statements of Formula may be entitled to c