Propiconazole Summary of Analytical Chemistry and Residue Data DP# 372878

Page 1 of 11 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF
CHEMICAL SAFETY AND
POLLUTION PREVENTION MEMORANDUM

Date: 11/03/10

Subject: Propiconazole. Summary of Anal ytical Chemistry and Residue Data. Amend
Established Tolerance for Mint. Esta blishment of Tolerances for Onion Subgroups 3-07 A and B and the Berry Subgroups 13-07 A, B, and G.

PC Code: 122101 DP Barcode: D372878 Decision No.: 425825 Registration No.: 100-617 Petition No.: 9E7659 Regulat ory Action: Section 3 Risk Assessment Type: Chemistry Case No.: NA

TXR No.: NA CAS No.: 60207-90-1

MRID No. 47929501 40 CFR: 180.434

Reviewer: Jerry B. Stokes, Chemist
Risk Assessment Branch 4 Health Effects Division (7509P)

Through: Susan Hummel, Senior Chemist
Risk Assessment Branch 4 Health Effects Division (7509P)

To: Rebecca Daiss, Biologist
Risk Assessment Branch 4 Health Effects Division (7509P)

Barbara Madden, Risk Manager Emergency Response Branch Registration Division (RD, 7505P)

Executive Summary

Propiconazole is a triazole-type f ungicide (Group 3) that provides broad spectrum disease control on a variety of crops. Tolerances in/on plant and animal commodities are currently established for the combined residues of propiconazole, 1-[[2-(2,4-dichlorophenyl)-4 -propyl-1,3-dioxolan-2- yl]methyl]-1 H -1,2,4-triazole, and its metabolites determ ined as 2,4-dichlorobenzoic acid (2,4-Propiconazole Summary of Analytical Chemistry and Residue Data DP# 372878

Page 2 of 11 DCBA) and expressed as parent [40 CFR §180.4 34]. Tolerances on plant commodities range from 0.1 ppm to 40 ppm in/on gra ss straw, and tolerances on animal commodities range from 0.05 ppm in milk to 2.0 ppm in liver and kidney of livestock.

Syngenta Crop Protection (Syngenta) and Interreg ional Research Project No. 4 (IR-4) have submitted a petition supporting amended tolerances for uses on various crops for propiconazole, formulated as a 3.6 lb/gal emulsifiable concentrate (EC). Tolerances for peppermint and spearmint tops are to be increased from 3.5 to 10.0 ppm. Existing tolerances for berry group 13 (1.0 ppm), onion, bulb (0.2 ppm), onion, green (9 .0 ppm), and strawberry (1.3 ppm) are to
removed and the same tolerances to be rees tablished under new crop groupings: onion, bulb subgroup 3-07A (0.2 ppm), onion, green subgroup 3-07B (9.0 ppm), caneberry subgroup 13- 07A (1.0 ppm), bushberry subgroup 13-07B (1.0 ppm) , and low growing berry subgroup 13-07G (except cranberry) (1.3 ppm).

The nature of propiconazole residues in plants and animals is adequately understood based on the available peanut, wheat, grape, rice, celery, carrot, goat, a nd poultry metabolism studies. A major metabolic pathway in plants appears to be hydroxylation (pri marily of the beta-carbon) of the n-propyl group on the dioxolane ring of the cis/trans isomer s of propiconazole. These metabolites appear to readily form sugar conjugates . HED concluded that for plants and animals, residues of propiconazole and all its metabolites containing th e 2,4-dichlorophenyl moiety (2,4- DCBA), including conjugates, are of concern risk assessments. For tolerance expression, HED concluded that the current tolerance expression for propiconazole should include residues of propiconazole per se only. This allows for harmonization with the residue definition for Codex.

A GC method using flame ioniza tion detection (Method AG-354) is available for determining residues of propiconazole per se in/on plant commodities, and has an LOQ of 0.05 ppm. In addition, Multiresidue Methods Sec tion 302 can also be used to determine parent propiconazole in both plant and animal matrices. The valid ated LOQ for combined residues was 0.05 ppm in all raw and processed commodities. Each of the methods was validated in conjunction with the field trials and pro cessing studies.

The available field trial data are adequa te and support the propos ed use patterns for propiconazole (EC) on mint and other crops listed above. The number and geographic
distribution of the field trials are adequate, and the appropriate samples were collected. Samples were analyzed using adequate analytical methods and the sample storage intervals are supported by the available storage stability data. Adequate storage stability data are available indicating that residues of propic onazole are stable at ≤ -15 C from 4-39 mont hs in a variety of
commodities.

There are no feedstuffs associated with the propo sed uses in this petition. Therefore, livestock dietary burdens are not addressed.

Adequate confined rotational crop studies are available indicating that the residues in rotational crops are similar to the primary crops. The c onfined studies also support the 105-day plant-back interval (PBI) currently listed on product labels for crops w ithout direct uses. Currently, propiconazole tolerances for inadvertent residues in/on al falfa forage and hay at 0.1 ppm.Propiconazole Summary of Analytical Chemistry and Residue Data DP# 372878

Page 3 of 11 Residue Chemistry Deficiencies

Interregional Research Project No. 4 (IR-4) have submitted a petition supporting amended tolerances for uses on various crops for propicon azole, formulated as a 3.6 lb/gal emulsifiable concentrate (EC). Tolerances for peppermint and spearmint tops are to be increased from 3.5 to 10.0 ppm. Existing tolerances for berry group 13 (1.0 ppm), onion, bulb (0.2 ppm), onion, green (9.0 ppm), and strawberry (1.3 ppm) are to removed and the same tolerances to be reestablished under new crop groupings: onion, bulb subgrou p 3-07A (0.2 ppm), onion, green subgroup 3- 07B (9.0 ppm), caneberry subgroup 13-07A (1.0 ppm), bushberry subgroup 13-07B (1.0 ppm), and low growing berry subgroup 13-07G (except cranberry) (1.3 ppm).

Conclusion : No major deficiencies were noted in the subject petition that would preclude establishing the proposed changes fo r propiconazole as listed above.

Background

Propiconazole is a triazole-type f ungicide (Group 3) that provides broad spectrum disease control through inhibition of sterol biosynt hesis in fungi. It is register ed to Syngenta Crop Protection for the control of fungal diseases on a va riety of crops. It is formul ated as 3.6 lb/gal emulsifiable concentrates (EC) under the trade name Tilt®. Other propiconazole end-use products are marketed in the United States under a variety of trade names. However, the 3.6 lb/gal EC product used in this peti tion will be discussed.

Permanent tolerances are currently established for the combined residu es of propiconazole, 1- [[2-(2,4-dichlorophenyl)-4-pr opyl-1,3-dioxolan-2-yl]methyl]-1 H -1,2,4-triazole, and its metabolites determined as 2,4-DCBA and expressed in parent equivalents, at levels ranging from 0.1 ppm on numerous plant commodities to 40 ppm in/on grass straw [40 CFR §180.434(a)].
Permanent tolerances are also established for the combined residues of propiconazole and its metabolites determined as 2,4-DCBA at 0.1 ppm in fat, meat, and meat byproducts (except liver and kidney) of livestock, 2.0 ppm in liver and ki dney of livestock, and at 0.05 ppm in milk; however, no tolerances have been established fo r eggs and poultry commodities. Time-limited tolerances are established for combined propi conazole residues in/ on a variety of plant commodities at level of 2.0 ppm in/on nectarin e and peach [40 CFR §180.434(b)]. In addition, tolerances with regional restric tions have been established for combined propiconazole residues at 1.0 ppm in/on cranberry and at 0.5 in/on w ild rice grain[40 CFR §180.434(c)]. Tolerances
with inadvertent residues have been established for combined propiconazole residues at 0.1 ppm in/on alfalfa forage and alfalfa hay.Propiconazole Summary of Analytical Chemistry and Residue Data DP# 372878

Page 4 of 11

Table 1. Nomenclature of Propiconazole

Compound

N N N

O O

Cl Cl

Common name Propiconazole

Company experimental names CGA-64250

IUPAC name 1-[2-(2,4_dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1 H -1,2,4_triazole

CAS name 1-[[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl]methyl]-1 H -1,2,4-triazole

CAS # 60207-90-1

End-use products/EP 3.6 lb/gal EC (EPA Reg. Nos. 100-617

Table 2. Physicochemical Properties of Technical Grade Propiconazole.

Parameter Value Reference

Boiling point 120 C at 1.9 Pa, >250 C at 101.325 kPa MRID No. 43698701

pH 4.9 at 25 C (1% aqueous dispersion) MRID No. 43698701

Density 1.289 g/cm 3 at 20 C MRID No. 43698701

Water solubility 0.10 g/L at 20 C MRID No. 41720301

Solvent solubility (temperature not specified) Completely miscible in ethanol, acetone, toluene and n-octanol. hexane = 47 g/L MRID No. 42030201

Vapor pressure 4.2 x 10 -7 mm Hg at 25 C MRID No. 41720301

Dissociation constant (pK

a ) 1.09 MRID No. 43698701

Octanol/water partition coefficient Log(K OW ) 3.72 at pH 6.6 and 25 C MRID No. 43698701

UV/visible absorption spectrum ( 8 max, nm) Not available MRID No. 40583703

860.1200 Directions for use

One current end-use product (EP) containing propiconazole that is registered for use on feed/food crops is marketed under the trade names Tilt ® Fungicide: 3.6 lb a.i./gal (EPA Reg. No. 100-617). Proposed use directions for these la bels are summarized below in Table 3.

Table 3. Summary of Directions for Proposed Use of Propiconazole on Mint

Application Timing, Type and Equipment Formulation [EPA Reg. No.] Single

rate (lb ai/A) Max. # of Apps. per

Season Max. Seasonal Rate (lb ai/A) PHI (days) Use Directions and Limitations Peppermint and Spearmint

Broadcast foliar applications beginning when plants are 2-4 inches in height. Apply with aerial or ground equipment 3.6 lb/gal EC [100-617] 0.113 0.338 7 Apply in a minimum of 20 gal/A Minimum RTI is 14 daysPropiconazole Summary of Analytical Chemistry and Residue Data DP# 372878

Page 5 of 11 860.1300 Nature of the Residue – Plants.

The nature of propiconazole residues in plan ts is adequately u nderstood (DP D329394, Y. Donovan, 6/15/06). These data indi cate that the major metabolic pathway in plants appears to involve hydroxylation of the n-propyl group on th e dioxolane ring of the cis/trans isomers of propiconazole, with subsequent conjugation to sugars. A possibl e alternative pathway involves
reductive deketalization of the dioxolane ring and sugar conjugati on of the resulting metabolite. The alkyl bridge between the phenyl and tr iazole rings is metabolized and free 1 H -1,2,4-triazole
is released. The free triazole is readily conjugated with the am ino acid, serine/alanine, forming
triazole aniline which is further metabolized to triazole acetic acid possibly through the
intermediate formation of triazole lactic acid. HED considers free triazole, triazole alanine, and
triazole acetic acid to be resi dues of concern in plants. Since these are common metabolites from several triazole containing pesticides, the risk assessment for triazoles has been assessed separately (HED memo of 2/7/06, M. Doherty, D322215).

HED has concluded that the residues of con cern should include propi conazole and all its metabolites containing the 2,4-DCBA moiety, includi ng conjugates for dietary risk assessment of food, as virtually all the residue data have been generated us ing a common moiety method that converts parent and all of the metabolites of concern to 2,4-DCBA. The tolerance expression should also be amended to include only propiconazole per se because 1) there are a number of pesticides that have 2,4-DCBA as common metabolite, and an enforcement agency may not be
able to determine if residues are due to misuse of propiconazole or th e proper use of other pesticides containing 2,4- DCBA; 2) propiconazole per se can be detected by FDA multiresidue methods; and 3) inclusion of only parent allows harmonization with the residue definition for the
Codex MRLs.

860.1300 Nature of the Residue – Livestock.

The nature of propiconazole residues in livesto ck is adequately understood based on acceptable goat and poultry metabolism studies (DP D 329394, Y. Donovan, 6/15/06). The Agency concluded that parent and all metabolites conve rtible to 2,4-DCBA are residues of concern for risk assessment, as the analytical method is a common moiety method th at detects all residues convertible to 2,4-DCBA. However, for tolera nce enforcement purposes, the current tolerance expression should be amended to include only propiconazole per se.

860.1340 Residue Analytical Methods.

Plant commodities : Samples were analyzed for propiconazole as 2,4-dichlorobenzoic methyl ester using the working method “Working Analytical Me thod for the Determination of Propiconazole in Mint Leaves as 2,4-Dichlorobenzoic Methyl Ester Using Gas Chromatography with Electron Capture Detector”. This method was adapted from “Determi nation of Total Residues of Propiconazole in Crops as 2,4-Dichlorobenzoic Acid by Capillary Gas Chromatography” (Method No. AG-454B). Minor modifications were made to improve the pe rformance of the method. Briefly, samples were extracted by refluxing with 20% concentrated ammonium hydroxide/methanol for 1 hour. The mixture was cooled and filtered. An aliquot of the extract was evaporated to dryness and the residue dissolved in NaOH. The sample was then heated for 1 hour and 15 minutes with potassium permanganate, where propiconazole and its metabolites were converted to 2,4-dichlorobenzoic acid.Propiconazole Summary of Analytical Chemistry and Residue Data DP# 372878

Page 6 of 11 After addition of water, the sample was partiti oned with 10% diethyl ether/hexane. The organic phase containing 2,4-dichlorobenzoic acid was ev aporated to dryness and derivatized with diazomethane in the presence of dodecane, which acts as a keeper to reduce losses due to the volatility of the derivative in subsequent steps. The derivative was cleaned up using an acidic alumina column. The cleaned extract was quantified by gas chromatography with electron capture
detection. A conversion factor of 1.79 was used to c onvert residues to propiconazole equivalents. The lowest level of method validation (LLMV) in this study was 0.050 ppm. Based on recoveries of samples fortified at the LLMV, the limit of detection (LOD) and limit of quantitation (LOQ) were calculated as 0.023 ppm and 0.070 ppm, respectively.

For enforcement purposes, residue Method AG-354 is available for determining propiconazole

per se in/on plant commodities using gas chromat ography and flame ionization detection, and the reported LOQ is 0.05 ppm. In addition, Multiresidue Methods Section 302 can also be used to detect parent propiconazole.

Animal commodities : No commodities in this pet ition are fed to livestock.

GLN 860.1360: Multiresidue Methods

The FDA PESTDATA database (PAM Volume I, Appendix I) indicates th at propiconazole is completely recovered (>80%) using Multiresi due Methods Section 302. The recovery of propiconazole metabolites CGA-91305, CGA-11 8244, and 1,2,4-triazole is variable using Section 302. Propiconazole and metabo lites CGA-91305, CGA-118244, and 1,2,4-triazole are not recovered using Multiresidue Methods Sections 303 and 304.

860.1380 Storage Stability.

Adequate storage stability data are available in dicating that residues of propiconazole and its metabolites determined as 2,4-DCBA are stable at ≤ -15 C for up to 39 months in a variety of commodities. (D329394, Y. Donovan, 6/15/06).

860.1400 Water, Fish, and Irrigated Crops

This guideline requirement is not relevant to the current petition as no uses are being proposed in/on water, fish, or irri gated crop for propiconazole.

860.1460 Food Handling

This guideline requirement is not relevant to the current petition as no food handling uses are being proposed for propiconazole.

860.1480 Meat, Milk, Poultry, and Eggs

This guideline requirement is no t relevant to the current petition as no uses in/on feedstuffs are being proposed for propiconazole.Propiconazole Summary of Analytical Chemistry and Residue Data DP# 372878

Page 7 of 11 860.1500 Crop Field Trials

47929501.der

Field trials have submitted supporting the amende d uses for propiconazole (EC) on mint. The
results from these studies are discusse d below and summarized in Table 7.

Table 7. Summary of Residue Data from Mint Field Trials with Propiconazole.

Crop/ Commodity MRID# Total Appl.

Rate (lb ai/A) End-use
Product PHI (days) Combined Residues (ppm) 1

n Min. Max. HAFT 2 Median 3
(STMdR) Mean 3
(STMR) Std.

Dev. Mint (0.225 lb ai/A total application rate, 30-day PHI)

Mint, hay 4792501 0.1125 (1x) 3.6 lb/gal

EC 7 10 0.114 5.453 5.446 3.556 3.316 1.977

1 Unless otherwise indicated, total propiconazole residues we re determined as 2,4-DCBA and are expressed in parent equivalents. The method LOQ for propiconazole residues is 0.07 ppm The LOD is 0.023 ppm.

2 HAFT = Highest Average Field Trial.

3 STMdR = Supervised Trial Median Residu e; STMR = Supervised Trial Mean Residue.

4 The field trial application rate relative to the ma ximum proposed use rate is listed in parentheses.

Mint. In five field trials conducted during 1995 in Regions 5 and 11 (44416501.der), propiconazole (3.6 lb/gal EC) was a pplied 3 times to established fields of mint as broadcast foliar applications at 0.1125 lb ai/A/appli cation at RTIs of 6-8 days, fo r a total of 0.3375 lb ai/A/season (1x rate). The initial application was made wh en plants were 2-4 inches in height, and all applications were made using ground equipment. Duplicate control and tr eated samples of fresh mint hay were harvested from each site at 7 DAT. Samples were stored frozen from collection to analysis for up to 294 days, an interval supporte d by available storage stability data. Total residues of propiconazole and its DCBA contai ning metabolites in/on mint were determined using a GC/ECD Method AG-454B, which was ade quately validated in conjunction with the analysis of field trial samples. The valid ated method LOQ is 0.07 ppm, and an LOD is 0.023

ppm.

Following applications of propiconazole (EC) at rates totaling 0.1125 lb ai/A/season (1x rate), total propiconazole residues were 0.114-5.453 ppm and averaged 3.316 ppm in/on 10 samples of mint hay harvested at 7 DAT.

Conclusions: The available field trial data are ad equate and support the proposed amended use patterns for propiconazole on mint. The number a nd geographic distribution of the field trials are adequate, and the appropriate samples were collected at the proposed PHI. Data were generated for only the EC formulation.

Other : The existing tolerances for berry group 13 (1.0 ppm), onion, bulb (0.2 ppm), onion, green (9.0 ppm), and strawberry (1.3 ppm) are adequate to cover any propiconazole residues under new crop groupings: onion, bulb subgrou p 3-07A (0.2 ppm), onion, green subgroup 3- 07B (9.0 ppm), caneberry subgroup 13-07A (1.0 ppm), bushberry subgroup 13-07B (1.0 ppm), and low growing berry subgroup 13-07G (except cranberry) (1.3 ppm).Propiconazole Summary of Analytical Chemistry and Residue Data DP# 372878

Page 8 of 11 860.1520 Processed Food and Feed

Mint. Adequate data are available from two mi nt processing studies (DP Barcode D209468, W. Wassell, 4/25/95). In two field trials, propiconazole (EC) was a pplied to mint at rates up to 0.34 lb ai/A (1.5x labeled rate). Samples of fresh mint hay were cut 90 DAT, air dried, and distilled to yield mint oil. Samples of mint hay and oil were stored for up to 224 days prior to analysis using an adequate GC/ECD method (AG-454B). Total propiconazole residues were 0.12 ppm in fresh hay from both field trials and were <0.05 and 0.08 ppm in oil from the two sites, for an average processing factor of 0.5x for mint oil. Ther efore, a separate tolera nce for mint oil is not required.

Conclusions: Adequate processing studies, reflecting the measurement of total combined residues, are available for mint.

860.1650 Submittal of Analytic al Reference Standards

An analytical reference standard for propiconazole is available at the EPA National Pesticide Standards Repository.

860.1850/860.1900 Confined and Field Accumu lation in Rotational Crops

The nature of the residue in confined ro tational crops is understood (D329394, Y. Donovan, 6/15/06). Based on acceptable st udies previously reviewed by EFED, the metabolism of propiconazole in rotational crops is similar to that in primary crops. Plant-back restrictions have been established for propiconazole products regi stered for use on rotational crops based on the confined rotational crop studies. Labels specify that any food/feed crops not listed on the label should not be planted within 105 days of treatme nt. Tolerances for in advertent residues of propiconazole in/on alfalfa plan ted in rotation with propiconazo le-treated crops have been established at 0.1 ppm for alfalfa forage and hay.

860.1550 Proposed Tolerances

Permanent tolerances are currently established fo r the combined residues of propiconazole and its 2,4-DCBA containing metabolites at levels ranging from 0.1-40 ppm in/on plant commodities [40 CFR §180.434(a)]. Permanent tolerances are al so established for the combined residues of propiconazole and its 2,4-DCBA containing metabo lites at 0.1 ppm in fat, meat, and meat byproducts (except liver and kidney) of livestock, 2.0 ppm in liver and kidney of livestock, and at 0.05 ppm in milk; however, no tolerances ha ve been established for eggs and poultry commodities. However, HED has determined that the current tolerance expression for plant and
animal commodities is not appropriate and has previously recommended that the tolerance expression be revised to include only parent.

Tolerances for peppermint and spearmint tops are to be increased from 3.5 to 10.0 ppm. Existing tolerances for berry group 13 (1.0 ppm ), onion, bulb (0.2 ppm), onion, green (9.0 ppm), and strawberry (1.3 ppm) are to removed and the same tolerances to be reestablished under new crop groupings: onion, bulb subgroup 3-07A ( 0.2 ppm), onion, green subgroup 3-07B (9.0Propiconazole Summary of Analytical Chemistry and Residue Data DP# 372878

Page 9 of 11 ppm), caneberry subgroup 13-07A (1.0 ppm), bushberry subgroup 13-07B (1.0 ppm), and low growing berry subgroup 13-07G (except cranberry) (1.3 ppm).

The Codex Alimentarius Commission has estab lished several maximum residue limits (MRLs) for propiconazole in/on various raw agricultura l commodities. The Codex MRLs are expressed in terms of propiconazole per se , which is the same as the US tolerance expression, recommended by the RED for existing tolerances a nd for the new uses. In addition, both Canada
and Mexico have established MRLs/tolerances on several commodities which also have U.S. tolerances. To the extent possible, U.S. tolera nces have been harmonized with Codex, Canadian,
and Mexican MRLs.

Table 9. Tolerance Summary for Propiconazole

Crop Commodity Proposed or
Established
Tolerance

(ppm) HED
Recommended
Tolerance

(ppm) Comments ( Correct Commodity Definition) Tolerances under §180.434(a) to be Removed Crop Group 13- Berries Group 1.0 Remove Mint, spearmint, tops 3.5 Remove Mint, peppermint, tops 3.5 Remove Onion, bulb 0.3 Remove Onion, green 9.0 Remove Strawberry 1.3 Remove

Tolerances under §180.434(a) to be Added Mint, spearmint, tops 3.5 10.0 Data are adequate to support the use. Mint, peppermint, tops 3.5 10.0 Data are adequate to support the use. Onion, bulb subgroup 3-07A 0.2 0.2 Data are adequate to support the use. Onion, green, subgroup 3-07B 9.0 9.0 Data are adequate to support the use. Caneberry, subgroup 13-07A 1.0 1.0 Data are adequate to support the use. Bushberry, subgroup 13-07B 1.0 1.0 Data are adequate to support the use.

Low growing berry subgroup 13-07G, except cranberry 1.3 1.3 Tolerance is currently established for strawberry. Data are adequate to support
the use.Propiconazole Summary of Analytical Chemistry and Residue Data DP# 372878

Page 10 of 11 References

DP Barcode: D329394 Subject: Propiconazole (122101): Reregistra tion Eligibility Deci sion (RED) Document; Revised Residue Chemistry Considerations.

From: Y. Donovan
To: M. Goodis and C. Scheltema
Dated: 6/15/06 MRID(s): None

DP Barcode: D219664 Subject: PP#5F04591, Propiconazole on the Berry Crop Grouping, Carrots, and Onions (green and dry bulb). From: L. Kutney
To: D. McCall
Dated: 6/14/96 MRID(s): 43786401-43786404

DP Barcode: D209468 Subject: PP#2E04047. Propiconazole (Tilt® Fungicide) in or on Mint. Amendment
submitted on 10/24/94.

From: Y. Donovan
To: H. Jamerson and J. Smith
Dated: 4/25/95 MRID(s): 43424601

Attachments:

Appendix I - International Residue Limits StatusPropiconazole Summary of Analytical Chemistry and Residue Data DP# 372878

Page 11 of 11 Appendix I – International Residue Limits

INTERNATIONAL RESIDUE LIMIT STATUS

Chemical Name: 1-[[2-(2,4-

dichlorophenyl)-4-propyl1,3-dioxolan-2-yl]methyl]-

1 H -1,2,4-triazole Common Name: Propiconazole  Proposed tolerances
 Reevaluated tolerance
X Other Date: 09/14/10

Codex Status (Maximum Residue Limits) U. S. Tolerances

X

 No Codex proposal step 6 or above



 No Codex proposal step 6 or above for the crops requested Petition Number: 9E7659

DP Barcode: D372878
Other Identifier:

Residue definition (step 8/CXL): Propiconazole Reviewer/Branch: J. Stokes/ RAB4

Residue definition:

Tolerances are currently e xpressed as the combined residues of propiconazole and its metabolites determined as 2,4-DCBA and expressed as parent. However, HED has recommended that the tolerance expression be changed to include only parent.

Crop (s) 1 MRL (mg/kg) Crop(s) Proposed or Established Tolerance (ppm)

Mint, spearmint, tops 10.0

Mint, peppermint, tops 10.0

Onion, bulb subgroup 3-07A 0.2

Onion, green, subgroup 3-07B 9.0

Caneberry, subgroup 13-07A 1.0

Bushberry, subgroup 13-07B 1.0

Low growing berry subgroup 13- 07G, except cranberry 1.3

Limits for Canada Limits for Mexico

 No Limits  No Limits for the crops requested  No Limits No Limits for the crops requested
Residue definition: Propiconazole and its metabolites including the 2,4-DCBA moiety Residue definition: Propiconazole

Crop(s) MRL (mg/kg) Crop(s) MRL (ppm)

Dried blueberries 0.15

Blueberries 0.02
blackberries, loganberries and raspberries 0.7 proposed

N otes/Special Instructions: