Exhibit 4.6


 


BICYCLE
THERAPEUTICS PLC


 


and


 


_____________,
As Warrant Agent


 


Form of
Ordinary Shares

Warrant Agreement


 


Dated
As Of __________


 






    


    


    







 


 


Bicycle
Therapeutics plc Form of Ordinary Shares Warrant Agreement


 


This
Ordinary Shares Warrant Agreement (this “Agreement”), dated as of [●], between Bicycle
Therapeutics plc, a public limited company incorporated under the laws of England and Wales (the “Company”),
and [●], a [corporation] [national banking association] organized and existing under the laws of [●] and having a
corporate trust office in [●], as warrant agent (the “Warrant Agent”).


 


Whereas,
the Company proposes to sell [If Warrants are sold with other securities —[title of such other securities being
offered] (the “Other Securities”) with] warrant certificates evidencing one or more warrants (the “Warrants”
or, individually, a “Warrant”) representing the right to subscribe for Ordinary Shares of the Company,
nominal value £0.01 per share (the “Warrant Securities”), such warrant certificates and other
warrant certificates issued pursuant to this Agreement being herein called the “Warrant Certificates”;
and


 


Whereas,
the Company desires the Warrant Agent to act on behalf of the Company, and the Warrant Agent is willing so to act,
in connection with the issuance, registration, transfer, exchange, exercise and replacement of the Warrant Certificates, and in
this Agreement wishes to set forth, among other things, the form and provisions of the Warrant Certificates and the terms and
conditions on which they may be issued, registered, transferred, exchanged, exercised and replaced.


 


Now
Therefore, in consideration of the premises and of the mutual agreements herein contained, the parties hereto agree
as follows:


 


Article 1


 


ISSUANCE
OF WARRANTS AND EXECUTION AND

DELIVERY OF WARRANT CERTIFICATES


 


1.1            Issuance
of Warrants. [If Warrants alone —Upon issuance, each Warrant Certificate shall evidence one or more Warrants.]
[If Other Securities and Warrants —Warrant Certificates will be issued in connection with the issuance of
the Other Securities but shall be separately transferable and each Warrant Certificate shall evidence one or more Warrants.] Each
Warrant evidenced thereby shall represent the right, subject to the provisions contained herein and therein, to subscribe for
one Warrant Security. [If Other Securities and Warrants —Warrant Certificates will be issued with the Other
Securities and each Warrant Certificate will evidence [●] Warrants for each [$[●] principal amount] [[●] shares]
of Other Securities issued.]


 


1.2            Execution
and Delivery of Warrant Certificates. Each Warrant Certificate, whenever issued, shall be in registered form substantially
in the form set forth in Exhibit A hereto, shall be dated the date of its countersignature by the Warrant Agent and
may have such letters, numbers, or other marks of identification or designation and such legends or endorsements printed, lithographed
or engraved thereon as the officers of the Company executing the same may approve (execution thereof to be conclusive evidence
of such approval) and as are not inconsistent with the provisions of this Agreement, or as may be required to comply with any
law or with any rule or regulation made pursuant thereto or with any rule or regulation of any securities exchange on
which the Warrants may be listed, or to conform to usage. The Warrant Certificates shall be signed on behalf of the Company by
any of its present or future chief executive officers, presidents, senior vice presidents, vice presidents, chief financial officers,
chief legal officers, treasurers, assistant treasurers, controllers, assistant controllers, secretaries or assistant secretaries
under its corporate seal reproduced thereon. Such signatures may be manual or facsimile signatures of such authorized officers
and may be imprinted or otherwise reproduced on the Warrant Certificates. The seal of the Company may be in the form of a facsimile
thereof and may be impressed, affixed, imprinted or otherwise reproduced on the Warrant Certificates.


 






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No Warrant Certificate
shall be valid for any purpose, and no Warrant evidenced thereby shall be exercisable, until such Warrant Certificate has been
countersigned by the manual signature of the Warrant Agent. Such signature by the Warrant Agent upon any Warrant Certificate executed
by the Company shall be conclusive evidence that the Warrant Certificate so countersigned has been duly issued hereunder.


 


In case any officer
of the Company who shall have signed any of the Warrant Certificates either manually or by facsimile signature shall cease to
be such officer before the Warrant Certificates so signed shall have been countersigned and delivered by the Warrant Agent, such
Warrant Certificates may be countersigned and delivered notwithstanding that the person who signed such Warrant Certificates ceased
to be such officer of the Company; and any Warrant Certificate may be signed on behalf of the Company by such persons as, at the
actual date of the execution of such Warrant Certificate, shall be the proper officers of the Company, although at the date of
the execution of this Agreement any such person was not such officer.


 


The term “holder”
or “holder of a Warrant Certificate” as used herein shall mean any person in whose name at the time
any Warrant Certificate shall be registered upon the books to be maintained by the Warrant Agent for that purpose.


 


1.3            Issuance
of Warrant Certificates. Warrant Certificates evidencing the right to subscribe for Warrant Securities may be executed by
the Company and delivered to the Warrant Agent upon the execution of this Agreement or from time to time thereafter. The Warrant
Agent shall, upon receipt of Warrant Certificates duly executed on behalf of the Company, countersign such Warrant Certificates
and shall deliver such Warrant Certificates to or upon the order of the Company.


 


Article 2


 


WARRANT
PRICE, DURATION AND EXERCISE OF WARRANTS


 


2.1            Warrant
Price. During the period specified in Section 2.2, each Warrant shall, subject to the terms of this Agreement and the
applicable Warrant Certificate, entitle the holder thereof to subscribe for the number of Warrant Securities specified in the
applicable Warrant Certificate at an exercise price of $[●] per Warrant Security, subject to adjustment upon the occurrence
of certain events, as hereinafter provided. Such subscription price per Warrant Security is referred to in this Agreement as the
 “Warrant Price.”


 


2.2            Duration
of Warrants. Each Warrant may be exercised in whole or in part at any time, as specified herein, on or after [the date thereof]
[●] and at or before [●] p.m., [City] time, on [●] or such later date as the Company may designate by notice
to the Warrant Agent and the holders of Warrant Certificates mailed to their addresses as set forth in the record books of the
Warrant Agent (the “Expiration Date”). Each Warrant not exercised at or before [●] p.m., [City]
time, on the Expiration Date shall become void, and all rights of the holder of the Warrant Certificate evidencing such Warrant
under this Agreement shall cease.


 






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2.3            Exercise
of Warrants.


 


(a)            During
the period specified in Section 2.2, the Warrants may be exercised to subscribe for a whole number of Warrant Securities
in registered form by providing certain information as set forth on the reverse side of the Warrant Certificate and by paying
in full, in lawful money of the United States of America, [in cash or by certified check or official bank check in New York Clearing
House funds] [by bank wire transfer in immediately available funds] the Warrant Price for each Warrant Security with respect to
which a Warrant is being exercised to the Warrant Agent at its corporate trust office, provided that such exercise is subject
to receipt within five business days of such payment by the Warrant Agent of the Warrant Certificate with the form of election
to subscribe for Warrant Securities set forth on the reverse side of the Warrant Certificate properly completed and duly executed.
The date on which payment in full of the Warrant Price is received by the Warrant Agent shall, subject to receipt of the Warrant
Certificate as aforesaid, be deemed to be the date on which the Warrant is exercised; provided, however, that if, at the date
of receipt of such Warrant Certificates and payment in full of the Warrant Price, the transfer books for the Warrant Securities
purchasable upon the exercise of such Warrants shall be closed, no such receipt of such Warrant Certificates and no such payment
of such Warrant Price shall be effective to constitute the person so designated to be named as the holder of record of such Warrant
Securities on such date, but shall be effective to constitute such person as the holder of record of such Warrant Securities for
all purposes at the opening of business on the next succeeding day on which the transfer books for the Warrant Securities purchasable
upon the exercise of such Warrants shall be opened, and the certificates for the Warrant Securities in respect of which such Warrants
are then exercised shall be issuable as of the date on such next succeeding day on which the transfer books shall next be opened,
and until such date the Company shall be under no duty to deliver any certificate for such Warrant Securities. The Warrant Agent
shall deposit all funds received by it in payment of the Warrant Price in an account of the Company maintained with it and shall
advise the Company by telephone at the end of each day on which a payment for the exercise of Warrants is received of the amount
so deposited to its account. The Warrant Agent shall promptly confirm such telephone advice to the Company in writing.


 


(b)            The
Warrant Agent shall, from time to time, as promptly as practicable, advise the Company of (i) the number of Warrant Securities
with respect to which Warrants were exercised, (ii) the instructions of each holder of the Warrant Certificates evidencing
such Warrants with respect to delivery of the Warrant Securities to which such holder is entitled upon such exercise, (iii) delivery
of Warrant Certificates evidencing the balance, if any, of the Warrants for the remaining Warrant Securities after such exercise,
and (iv) such other information as the Company shall reasonably require.


 


(c)            As
soon as practicable after the exercise of any Warrant, the Company shall issue to or upon the order of the holder of the Warrant
Certificate evidencing such Warrant the Warrant Securities to which such holder is entitled, in registered form, registered in
such name or names as may be directed by such holder. If fewer than all of the Warrants evidenced by such Warrant Certificate
are exercised, the Company shall execute, and an authorized officer of the Warrant Agent shall manually countersign and deliver,
a new Warrant Certificate evidencing Warrants for the number of Warrant Securities remaining unexercised.


 


(d)            The
Company shall not be required to pay any stamp duty, stamp duty reserve tax, issuance, transfer restriction tax or other tax,
duty, fee or other governmental charge, including any penalty or interest in respect thereof (a “Transfer Tax”)
arising in relation to any transfer, issue or other delivery of the Warrant Securities, and in the event that any such
transfer, issue or other delivery is involved, the Company shall not be required to transfer, issue or otherwise deliver any
Warrant Security until such Transfer Tax shall have been paid or it has been established to the Company’s satisfaction
that no such Transfer Tax is due or may arise.


 


(e)            Prior
to the issuance of any Warrants pursuant to this Agreement, and at all times through the Expiration Date, the Company shall ensure
that the Directors have sufficient authority and power under section 551 and section 570 of the UK Companies Act 2006 to issue
such Warrants.


 






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Article 3


 


OTHER
PROVISIONS RELATING TO RIGHTS OF HOLDERS OF

WARRANT CERTIFICATES


 


3.1            No
Rights as Warrant Securityholder Conferred by Warrants or Warrant Certificates. No Warrant Certificate or Warrant evidenced
thereby shall entitle the holder thereof to any of the rights of a holder of Warrant Securities, including, without limitation,
the right to receive the payment of dividends or distributions, if any, on the Warrant Securities or to exercise any voting rights,
except to the extent expressly set forth in this Agreement or the applicable Warrant Certificate.


 


3.2            Lost,
Stolen, Mutilated or Destroyed Warrant Certificates. Upon receipt by the Warrant Agent of evidence reasonably satisfactory
to it and the Company of the ownership of and the loss, theft, destruction or mutilation of any Warrant Certificate and/or indemnity
reasonably satisfactory to the Warrant Agent and the Company and, in the case of mutilation, upon surrender of the mutilated Warrant
Certificate to the Warrant Agent for cancellation, then, in the absence of notice to the Company or the Warrant Agent that such
Warrant Certificate has been acquired by a bona fide purchaser, the Company shall execute, and an authorized officer of the Warrant
Agent shall manually countersign and deliver, in exchange for or in lieu of the lost, stolen, destroyed or mutilated Warrant Certificate,
a new Warrant Certificate of the same tenor and evidencing Warrants for a like number of Warrant Securities. Upon the issuance
of any new Warrant Certificate under this Section 3.2, the Company may require the payment of a sum sufficient to cover any
tax or other governmental charge that may be imposed in relation thereto and any other expenses (including the fees and expenses
of the Warrant Agent) in connection therewith. Every substitute Warrant Certificate executed and delivered pursuant to this Section 3.2
in lieu of any lost, stolen or destroyed Warrant Certificate shall represent an additional contractual obligation of the Company,
whether or not the lost, stolen or destroyed Warrant Certificate shall be at any time enforceable by anyone, and shall be entitled
to the benefits of this Agreement equally and proportionately with any and all other Warrant Certificates duly executed and delivered
hereunder. The provisions of this Section 3.2 are exclusive and shall preclude (to the extent lawful) all other rights and
remedies with respect to the replacement of mutilated, lost, stolen or destroyed Warrant Certificates.


 


3.3            Holder
of Warrant Certificate May Enforce Rights. Notwithstanding any of the provisions of this Agreement, any holder of a Warrant
Certificate, without the consent of the Warrant Agent, the holder of any Warrant Securities or the holder of any other Warrant
Certificate, may, in such holder’s own behalf and for such holder’s own benefit, enforce, and may institute and maintain
any suit, action or proceeding against the Company suitable to enforce, or otherwise in respect of, such holder’s right
to exercise the Warrants evidenced by such holder’s Warrant Certificate in the manner provided in such holder’s Warrant
Certificate and in this Agreement.


 


3.4            Adjustments.


 


(a)            In
case the Company shall at any time subdivide its issued ordinary shares into a greater number of shares, the Warrant Price in
effect immediately prior to such subdivision shall be proportionately reduced and the number of Warrant Securities purchasable
under the Warrants shall be proportionately increased. Conversely, in case the outstanding ordinary shares of the Company shall
be consolidated into a smaller number of shares, the Warrant Price in effect immediately prior to such consolidation shall be
proportionately increased and the number of Warrant Securities purchasable under the Warrants shall be proportionately decreased.


 


(b)            If
at any time or from time to time the holders of Ordinary Shares (or any shares or other securities at the time receivable upon
the exercise of the Warrants) shall have received or become entitled to receive, without payment therefor,


 






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(i)            Ordinary
Shares or any shares or other securities which are at any time directly or indirectly convertible into or exchangeable for Ordinary
Shares, or any rights or options to subscribe for, purchase or otherwise acquire any of the foregoing by way of dividend or other
distribution;


 


(ii)            any
cash paid or payable otherwise than as a cash dividend paid or payable out of the Company’s realized profits;


 


(iii)            any
evidence of the Company’s indebtedness or rights to subscribe for or purchase the Company’s indebtedness; or


 


(iv)            Ordinary
Shares or additional shares or other securities or property (including cash) by way of spinoff, split-up, reclassification, consolidation
of shares or similar corporate rearrangement (other than shares of Ordinary Shares issued as a subdivision or adjustments in respect
of which shall be covered by the terms of Section 3.4(a) above), then and in each such case, the holder of each Warrant
shall, upon the exercise of the Warrant, be entitled to receive, in addition to the number of Warrant Securities receivable thereupon,
and without payment of any additional consideration therefore, the amount of ordinary shares and other securities and property
(including cash and indebtedness or rights to subscribe for or purchase indebtedness) which such holder would hold on the date
of such exercise had such holder been the holder of record of such Warrant Securities as of the date on which holders of Ordinary
Shares received or became entitled to receive such shares or all other additional shares and other securities and property.


 


(c)            In
case of (i) any reclassification, capital reorganization, or change in the ordinary shares of the Company (other than as
a result of a subdivision, combination, or share dividend provided for in Section 3.4(a) or Section 3.4(b) above),
(ii) share exchange, merger or similar transaction of the Company with or into another person or entity (other than a share
exchange, merger or similar transaction in which the Company is the acquiring or surviving corporation and which does not result
in any change in the Ordinary Shares other than the issuance of additional Ordinary Shares) or (iii) the sale, exchange,
lease, transfer or other disposition of all or substantially all of the properties and assets of the Company as an entirety (in
any such case, a “Reorganization Event”), then, as a condition of such Reorganization Event, to the
extent permitted by applicable law and regulations lawful provisions shall be made, and duly executed documents evidencing the
same from the Company or its successor shall be delivered to the holders of the Warrants, so that the holders of the Warrants
shall have the right at any time prior to the expiration of the Warrants to subscribe for or purchase, at a total price equal
to that payable upon the exercise of the Warrants, the kind and amount of shares and other securities and property receivable
in connection with such Reorganization Event by a holder of the same number of Warrant Securities as were purchasable by the holders
of the Warrants immediately prior to such Reorganization Event. In any such case appropriate provisions shall be made with respect
to the rights and interests of the holders of the Warrants so that the provisions hereof shall thereafter be applicable with respect
to any shares or other securities and property deliverable upon exercise the Warrants, and appropriate adjustments shall be made
to the Warrant Price payable hereunder provided the aggregate subscription price shall remain the same. In the case of any transaction
described in clauses (ii) and (iii) above, the Company shall thereupon be relieved of any further obligation hereunder
or under the Warrants, and the Company as the predecessor corporation may thereupon or at any time thereafter be dissolved, wound
up or liquidated. Such successor or assuming entity thereupon may cause to be signed, and may issue either in its own name or
in the name of the Company, any or all of the Warrants issuable hereunder which heretofore shall not have been signed by the Company,
and may execute and deliver securities in its own name, in fulfillment of its obligations to deliver Warrant Securities upon exercise
of the Warrants. All the Warrants so issued shall in all respects have the same legal rank and benefit under this Agreement as
the Warrants theretofore or thereafter issued in accordance with the terms of this Agreement as though all of such Warrants had
been issued at the date of the execution hereof. In any case of any such Reorganization Event, such changes in phraseology and
form (but not in substance) may be made in the Warrants thereafter to be issued as may be appropriate. The Warrant Agent may receive
a written opinion of legal counsel as conclusive evidence that any such Reorganization Event complies with the provisions of this
Section 3.4.


 






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(d)            The
Company may, at its option, at any time until the Expiration Date, reduce the then current Warrant Price to any amount deemed
appropriate by the Board of Directors of the Company for any period not exceeding twenty consecutive days (as evidenced in a resolution
adopted by such Board of Directors), but only upon giving the notices required by Section 3.5 at least ten days prior to
taking such action.


 


(e)            Except
as herein otherwise expressly provided, no adjustment in the Warrant Price shall be made by reason of the issuance of ordinary
shares, or securities convertible into or exchangeable for ordinary shares, or securities carrying the right to subscribe for
or purchase any of the foregoing or for any other reason whatsoever.


 


(f)            No
fractional Warrant Securities shall be issued upon the exercise of Warrants. If more than one Warrant shall be exercised at one
time by the same holder, the number of full Warrant Securities which shall be issuable upon such exercise shall be computed on
the basis of the aggregate number of Warrant Securities subscribed for pursuant to the Warrants so exercised. Instead of any fractional
Warrant Security which would otherwise be issuable upon exercise of any Warrant, the Company shall pay a cash adjustment in respect
of such fraction in an amount equal to the same fraction of the last reported sale price (or bid price if there were no sales)
per Warrant Security, in either case as reported on the principal registered national securities exchange on which the Warrant
Securities are listed or admitted to trading on the business day that next precedes the day of exercise or, if the Warrant Securities
are not then listed or admitted to trading on any registered national securities exchange, the average of the closing high bid
and low asked prices as reported on the OTC Bulletin Board Service (the “OTC Bulletin Board”) operated
by the Financial Industry Regulatory Authority, Inc. (“FINRA” ) or, if not available on the OTC
Bulletin Board, then the average of the closing high bid and low asked prices as reported on any other U.S. quotation medium or
inter-dealer quotation system on such date, or if on any such date the Warrant Securities are not listed or admitted to trading
on a registered national securities exchange, are not included in the OTC Bulletin Board, and are not quoted on any other U.S.
quotation medium or inter-dealer quotation system, an amount equal to the same fraction of the average of the closing bid and
asked prices as furnished by any FINRA member firm selected from time to time by the Company for that purpose at the close of
business on the business day that next precedes the day of exercise.


 


(g)            Whenever
the Warrant Price then in effect is adjusted as herein provided, the Company shall mail to each holder of the Warrants at such
holder’s address as it shall appear on the books of the Company a statement setting forth the adjusted Warrant Price then
and thereafter effective under the provisions hereof, together with the facts, in reasonable detail, upon which such adjustment
is based.


 


(h)            Notwithstanding
anything to the contrary herein, in no event shall the Warrant Price, as adjusted in accordance with the terms hereof, be less
than the nominal value per ordinary share.


 






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3.5            Notice
to Warrantholders. In case the Company shall (a) effect any dividend or distribution described in Section 3.4(b),
(b) effect any Reorganization Event, (c) make any distribution on or in respect of the Ordinary Shares in connection
with the dissolution, liquidation or winding up of the Company, or (d) reduce the then current Warrant Price pursuant to
Section 3.4(d), then the Company shall mail to each holder of Warrants at such holder’s address as it shall appear
on the books of the Warrant Agent, at least ten days prior to the applicable date hereinafter specified, a notice stating (x) the
record date for such dividend or distribution, or, if a record is not to be taken, the date as of which the holders of record
of Ordinary Shares that will be entitled to such dividend or distribution are to be determined, (y) the date on which such
Reorganization Event, dissolution, liquidation or winding up is expected to become effective, and the date as of which it is expected
that holders of Ordinary Shares of record shall be entitled to exchange their Ordinary Shares for securities or other property
deliverable upon such Reorganization Event, dissolution, liquidation or winding up, or (z) the first date on which the then
current Warrant Price shall be reduced pursuant to Section 3.4(d). No failure to mail such notice nor any defect therein
or in the mailing thereof shall affect any such transaction or any adjustment in the Warrant Price required by Section 3.4.


 


3.6            [If
the Warrants are Subject to Acceleration by the Company, Insert — Acceleration of Warrants by the Company.


 


(a)            At
any time on or after [●], the Company shall have the right to accelerate any or all Warrants at any time by causing them
to expire at the close of business on the day next preceding a specified date (the “Acceleration Date”),
if the Market Price (as hereinafter defined) of the Ordinary Shares equals or exceeds [●] percent ([●]%) of the then
effective Warrant Price on any twenty Trading Days (as hereinafter defined) within a period of thirty consecutive Trading Days
ending no more than five Trading Days prior to the date on which the Company gives notice to the Warrant Agent of its election
to accelerate the Warrants.


 


(b)            (b) “Market
Price” for each Trading Day shall be, if the Ordinary Shares or American Depositary Shares (“ADSs”)
representing such Ordinary Shares are listed or admitted to trading on any registered national securities exchange, the last reported
sale price, regular way (or, if no such price is reported, the average of the reported closing bid and asked prices, regular way)
of the Ordinary Shares or ADSs, in either case as reported on the principal registered national securities exchange on which the
Ordinary Shares or ADSs are listed or admitted to trading or, if not listed or admitted to trading on any registered national
securities exchange, the average of the closing high bid and low asked prices as reported on the OTC Bulletin Board operated by
FINRA, or if not available on the OTC Bulletin Board, then the average of the closing high bid and low asked prices as reported
on any other U.S. quotation medium or inter-dealer quotation system, or if on any such date the Ordinary Shares or ADSs are not
listed or admitted to trading on a registered national securities exchange, are not included in the OTC Bulletin Board, and are
not quoted on any other U.S. quotation medium or inter-dealer quotation system, the average of the closing bid and asked prices
as furnished by any FINRA member firm selected from time to time by the Company for that purpose. “Trading Day” shall
be each Monday through Friday, other than any day on which securities are not traded in the system or on the exchange that is
the principal market for the Ordinary Shares or ADSs, as determined by the Board of Directors of the Company. In the event of
an acceleration of less than all of the Warrants, the Warrant Agent shall select the Warrants to be accelerated by lot, pro rata
or in such other manner as it deems, in its discretion, to be fair and appropriate.


 


(c)            Notice
of an acceleration specifying the Acceleration Date shall be sent by mail first class, postage prepaid, to each registered holder
of a Warrant Certificate representing a Warrant accelerated at such holder’s address appearing on the books of the Warrant
Agent not more than sixty days nor less than thirty days before the Acceleration Date. Such notice of an acceleration also shall
be given no more than twenty days, and no less than ten days, prior to the mailing of notice to registered holders of Warrants
pursuant to this Section 3.6, by publication at least once in a newspaper of general circulation in the City of New York.


 






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(d)            Any
Warrant accelerated may be exercised until [●] p.m., [City] time, on the business day next preceding the Acceleration Date.
The Warrant Price shall be payable as provided in Section 2.]


 


Article 4


 


EXCHANGE
AND TRANSFER OF WARRANT CERTIFICATES


 


4.1            Exchange
and Transfer of Warrant Certificates. Upon surrender at the corporate trust office of the Warrant Agent, Warrant Certificates
evidencing Warrants may be exchanged for Warrant Certificates in other denominations evidencing such Warrants or the transfer
thereof may be registered in whole or in part; provided that such other Warrant Certificates evidence Warrants for the same aggregate
number of Warrant Securities as the Warrant Certificates so surrendered. The Warrant Agent shall keep, at its corporate trust
office, books in which, subject to such reasonable regulations as it may prescribe, it shall register Warrant Certificates and
exchanges and transfers of outstanding Warrant Certificates, upon surrender of the Warrant Certificates to the Warrant Agent at
its corporate trust office for exchange or registration of transfer, properly endorsed or accompanied by appropriate instruments
of registration of transfer and written instructions for transfer, all in form satisfactory to the Company and the Warrant Agent.
No service charge shall be made for any exchange or registration of transfer of Warrant Certificates, but the Company may require
payment of a sum sufficient to cover any Transfer Tax that may arise in relation to any such exchange or registration of transfer.
Whenever any Warrant Certificates are so surrendered for exchange or registration of transfer, an authorized officer of the Warrant
Agent shall manually countersign and deliver to the person or persons entitled thereto a Warrant Certificate or Warrant Certificates
duly authorized and executed by the Company, as so requested. The Warrant Agent shall not be required to effect any exchange or
registration of transfer which will result in the issuance of a Warrant Certificate evidencing a Warrant for a fraction of a Warrant
Security or a number of Warrants for a whole number of Warrant Securities and a fraction of a Warrant Security. All Warrant Certificates
issued upon any exchange or registration of transfer of Warrant Certificates shall be the valid obligations of the Company, evidencing
the same obligations and entitled to the same benefits under this Agreement as the Warrant Certificate surrendered for such exchange
or registration of transfer.


 


4.2            Treatment
of Holders of Warrant Certificates. The Company, the Warrant Agent and all other persons may treat the registered holder of
a Warrant Certificate as the absolute owner thereof for any purpose and as the person entitled to exercise the rights represented
by the Warrants evidenced thereby, any notice to the contrary notwithstanding.


 


4.3            Cancellation
of Warrant Certificates. Any Warrant Certificate surrendered for exchange, registration of transfer or exercise of the Warrants
evidenced thereby shall, if surrendered to the Company, be delivered to the Warrant Agent and all Warrant Certificates surrendered
or so delivered to the Warrant Agent shall be promptly canceled by the Warrant Agent and shall not be reissued and, except as
expressly permitted by this Agreement, no Warrant Certificate shall be issued hereunder in exchange therefor or in lieu thereof.
The Warrant Agent shall deliver to the Company from time to time or otherwise dispose of canceled Warrant Certificates in a manner
satisfactory to the Company.


 






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Article 5


 


CONCERNING
THE WARRANT AGENT


 


5.1            Warrant
Agent. The Company hereby appoints [●] as Warrant Agent of the Company in respect of the Warrants and the Warrant Certificates
upon the terms and subject to the conditions herein set forth, and [●] hereby accepts such appointment. The Warrant Agent
shall have the powers and authority granted to and conferred upon it in the Warrant Certificates and hereby and such further powers
and authority to act on behalf of the Company as the Company may hereafter grant to or confer upon it. All of the terms and provisions
with respect to such powers and authority contained in the Warrant Certificates are subject to and governed by the terms and provisions
hereof.


 


5.2            Conditions
of Warrant Agent’s Obligations. The Warrant Agent accepts its obligations herein set forth upon the terms and conditions
hereof, including the following to all of which the Company agrees and to all of which the rights hereunder of the holders from
time to time of the Warrant Certificates shall be subject:


 


(a)            Compensation
and Indemnification. The Company agrees promptly to pay the Warrant Agent the compensation to be agreed upon with the Company
for all services rendered by the Warrant Agent and to reimburse the Warrant Agent for reasonable out-of-pocket expenses (including
reasonable counsel fees) incurred without negligence, bad faith or willful misconduct by the Warrant Agent in connection with
the services rendered hereunder by the Warrant Agent. The Company also agrees to indemnify the Warrant Agent for, and to hold
it harmless against, any loss, liability or expense incurred without negligence, bad faith or willful misconduct on the part of
the Warrant Agent, arising out of or in connection with its acting as Warrant Agent hereunder other than any Transfer Tax arising
in relation to any Warrant Certificates sold pursuant to this Agreement, including the reasonable costs and expenses of defending
against any claim of such liability.


 


(b)            Agent
for the Company. In acting under this Agreement and in connection with the Warrant Certificates, the Warrant Agent is acting
solely as agent of the Company and does not assume any obligations or relationship of agency or trust for or with any of the holders
of Warrant Certificates or beneficial owners of Warrants.


 


(c)            Counsel.
The Warrant Agent may consult with counsel satisfactory to it, which may include counsel for the Company, and the written
advice of such counsel shall be full and complete authorization and protection in respect of any action taken, suffered or omitted
by it hereunder in good faith and in accordance with the advice of such counsel.


 


(d)            Documents.
The Warrant Agent shall be protected and shall incur no liability for or in respect of any action taken or omitted by it in
reliance upon any Warrant Certificate, notice, direction, consent, certificate, affidavit, statement or other paper or document
reasonably believed by it to be genuine and to have been presented or signed by the proper parties.


 


(e)            Certain
Transactions. The Warrant Agent, and its officers, directors and employees, may become the owner of, or acquire any interest
in, Warrants, with the same rights that it or they would have if it were not the Warrant Agent hereunder, and, to the extent permitted
by applicable law, it or they may engage or be interested in any financial or other transaction with the Company and may act on,
or as depositary, trustee or agent for, any committee or body of holders of Warrant Securities or other obligations of the Company
as freely as if it were not the Warrant Agent hereunder. Nothing in this Agreement shall be deemed to prevent the Warrant Agent
from acting as trustee under any indenture to which the Company is a party.


 


(f)            No
Liability for Interest. Unless otherwise agreed with the Company, the Warrant Agent shall have no liability for interest on
any monies at any time received by it pursuant to any of the provisions of this Agreement or of the Warrant Certificates.


 






    9


    


    

 


(g)            No
Liability for Invalidity. The Warrant Agent shall have no liability with respect to any invalidity of this Agreement or any
of the Warrant Certificates (except as to the Warrant Agent’s countersignature thereon).


 


(h)            No
Responsibility for Representations. The Warrant Agent shall not be responsible for any of the recitals or representations
herein or in the Warrant Certificates (except as to the Warrant Agent’s countersignature thereon), all of which are made
solely by the Company.


 


(i)            No
Implied Obligations. The Warrant Agent shall be obligated to perform only such duties as are herein and in the Warrant Certificates
specifically set forth and no implied duties or obligations shall be read into this Agreement or the Warrant Certificates against
the Warrant Agent. The Warrant Agent shall not be under any obligation to take any action hereunder which may tend to involve
it in any expense or liability, the payment of which within a reasonable time is not, in its reasonable opinion, assured to it.
The Warrant Agent shall not be accountable or under any duty or responsibility for the use by the Company of any of the Warrant
Certificates authenticated by the Warrant Agent and delivered by it to the Company pursuant to this Agreement or for the application
by the Company of the proceeds of the Warrant Certificates. The Warrant Agent shall have no duty or responsibility in case of
any default by the Company in the performance of its covenants or agreements contained herein or in the Warrant Certificates or
in the case of the receipt of any written demand from a holder of a Warrant Certificate with respect to such default, including,
without limiting the generality of the foregoing, any duty or responsibility to initiate or attempt to initiate any proceedings
at law or otherwise or, except as provided in Section 6.2 hereof, to make any demand upon the Company.


 


5.3            Resignation,
Removal and Appointment of Successors.


 


(a)            The
Company agrees, for the benefit of the holders from time to time of the Warrant Certificates, that there shall at all times be
a Warrant Agent hereunder until all the Warrants have been exercised or are no longer exercisable.


 


(b)            The
Warrant Agent may at any time resign as agent by giving written notice to the Company of such intention on its part, specifying
the date on which its desired resignation shall become effective; provided that such date shall not be less than three months
after the date on which such notice is given unless the Company otherwise agrees. The Warrant Agent hereunder may be removed at
any time by the filing with it of an instrument in writing signed by or on behalf of the Company and specifying such removal and
the intended date when it shall become effective. Such resignation or removal shall take effect upon the appointment by the Company,
as hereinafter provided, of a successor Warrant Agent (which shall be a bank or trust company authorized under the laws of the
jurisdiction of its organization to exercise corporate trust powers) and the acceptance of such appointment by such successor
Warrant Agent. The obligation of the Company under Section 5.2(a) shall continue to the extent set forth therein notwithstanding
the resignation or removal of the Warrant Agent.


 


(c)            In
case at any time the Warrant Agent shall resign, or shall be removed, or shall become incapable of acting, or shall be adjudged
a bankrupt or insolvent, or shall commence a voluntary case under the Federal bankruptcy laws, as now or hereafter constituted,
or under any other applicable Federal or state bankruptcy, insolvency or similar law or shall consent to the appointment of or
taking possession by a receiver, custodian, liquidator, assignee, trustee, sequestrator (or other similar official) of the Warrant
Agent or its property or affairs, or shall make an assignment for the benefit of creditors, or shall admit in writing its inability
to pay its debts generally as they become due, or shall take corporate action in furtherance of any such action, or a decree or
order for relief by a court having jurisdiction in the premises shall have been entered in respect of the Warrant Agent in an
involuntary case under the Federal bankruptcy laws, as now or hereafter constituted, or any other applicable Federal or state
bankruptcy, insolvency or similar law, or a decree or order by a court having jurisdiction in the premises shall have been entered
for the appointment of a receiver, custodian, liquidator, assignee, trustee, sequestrator (or similar official) of the Warrant
Agent or of its property or affairs, or any public officer shall take charge or control of the Warrant Agent or of its property
or affairs for the purpose of rehabilitation, conservation, winding up or liquidation, a successor Warrant Agent, qualified as
aforesaid, shall be appointed by the Company by an instrument in writing, filed with the successor Warrant Agent. Upon the appointment
as aforesaid of a successor Warrant Agent and acceptance by the successor Warrant Agent of such appointment, the Warrant Agent
shall cease to be Warrant Agent hereunder.


 






    10


    


    

 


(d)            Any
successor Warrant Agent appointed hereunder shall execute, acknowledge and deliver to its predecessor and to the Company an instrument
accepting such appointment hereunder, and thereupon such successor Warrant Agent, without any further act, deed or conveyance,
shall become vested with all the authority, rights, powers, trusts, immunities, duties and obligations of such predecessor with
like effect as if originally named as Warrant Agent hereunder, and such predecessor, upon payment of its charges and disbursements
then unpaid, shall thereupon become obligated to transfer, deliver and pay over, and such successor Warrant Agent shall be entitled
to receive, all monies, securities and other property on deposit with or held by such predecessor, as Warrant Agent hereunder.


 


(e)            Any
corporation into which the Warrant Agent hereunder may be merged or converted or any corporation with which the Warrant Agent
may be consolidated, or any corporation resulting from any merger, conversion or consolidation to which the Warrant Agent shall
be a party, or any corporation to which the Warrant Agent shall sell or otherwise transfer all or substantially all the assets
and business of the Warrant Agent, provided that it shall be qualified as aforesaid, shall be the successor Warrant Agent under
this Agreement without the execution or filing of any paper or any further act on the part of any of the parties hereto.


 


Article 6


 


MISCELLANEOUS


 


6.1            Amendment.
This Agreement may be amended by the parties hereto, without the consent of the holder of any Warrant Certificate, for the
purpose of curing any ambiguity, or of curing, correcting or supplementing any defective provision contained herein, or making
any other provisions with respect to matters or questions arising under this Agreement as the Company and the Warrant Agent may
deem necessary or desirable; provided that such action shall not materially adversely affect the interests of the holders of the
Warrant Certificates.


 


6.2            Notices
and Demands to the Company and Warrant Agent. If the Warrant Agent shall receive any notice or demand addressed to the Company
by the holder of a Warrant Certificate pursuant to the provisions of the Warrant Certificates, the Warrant Agent shall promptly
forward such notice or demand to the Company.


 


6.3            Addresses.
Any communication from the Company to the Warrant Agent with respect to this Agreement shall be addressed to [●], Attention:
[●] and any communication from the Warrant Agent to the Company with respect to this Agreement shall be addressed to Bicycle
Therapeutics plc, B900, Babraham Research Campus, Cambridge, CB22 3AT, United Kingdom, Attention: [●] (or such other address
as shall be specified in writing by the Warrant Agent or by the Company).


 


6.4            Governing
Law. This Agreement and each Warrant Certificate issued hereunder shall be governed by and construed in accordance with the
laws of the State of New York.


 






    11


    


    

 


6.5            Delivery
of Prospectus. The Company shall furnish to the Warrant Agent sufficient copies of a prospectus meeting the requirements of
the Securities Act of 1933, as amended, relating to the Warrant Securities deliverable upon exercise of the Warrants (the “Prospectus”),
and the Warrant Agent agrees that upon the exercise of any Warrant, the Warrant Agent will deliver to the holder of the Warrant
Certificate evidencing such Warrant, prior to or concurrently with the delivery of the Warrant Securities issued upon such exercise,
a Prospectus. The Warrant Agent shall not, by reason of any such delivery, assume any responsibility for the accuracy or adequacy
of such Prospectus.


 


6.6            Obtaining
of Governmental Approvals. The Company will from time to time take all action which may be necessary to obtain and keep effective
any and all permits, consents and approvals of governmental agencies and authorities and securities act filings under United States
Federal and state laws (including without limitation a registration statement in respect of the Warrants and Warrant Securities
under the Securities Act of 1933, as amended), which may be or become requisite in connection with the issuance, sale, transfer,
and delivery of the Warrant Securities issued upon exercise of the Warrants, the issuance, sale, transfer and delivery of the
Warrants or upon the expiration of the period during which the Warrants are exercisable.


 


6.7            Persons
Having Rights Under the Agreement. Nothing in this Agreement shall give to any person other than the Company, the Warrant
Agent and the holders of the Warrant Certificates any right, remedy or claim under or by reason of this Agreement.


 


6.8            Headings.
The descriptive headings of the several Articles and Sections of this Agreement are inserted for convenience only and shall
not control or affect the meaning or construction of any of the provisions hereof.


 


6.9            Counterparts.
This Agreement may be executed in any number of counterparts, each of which as so executed shall be deemed to be an original,
but such counterparts shall together constitute but one and the same instrument.


 


6.10            Inspection
of Agreement. A copy of this Agreement shall be available at all reasonable times at the principal corporate trust office
of the Warrant Agent for inspection by the holder of any Warrant Certificate. The Warrant Agent may require such holder to submit
such holder’s Warrant Certificate for inspection by it.


 






    12


    


    

 


 


In
Witness Whereof, the parties hereto have caused this Agreement to be duly executed as of the day and year first above
written.


 





 


	 	Bicycle Therapeutics plc, as Company
	 
	 	By:	 
	 
	 	Name:	 
	 
	 	Title:	 
	 
	 	Attest:	 
	 	 	 
	 
	 	Countersigned
	 
	 	[●],
    as Warrant Agent
	 
	 	By:	 
	 
	 	Name:	 
	 
	 	Title:	 
	 
	 	Attest:	 
	 	 	 




 


[Signature
Page to Bicycle Therapeutics plc Ordinary shares Warrant Agreement]


 






    


    


    







 





 


Exhibit A


 


FORM OF WARRANT CERTIFICATE


 


[FACE OF WARRANT CERTIFICATE]


 


	[Form of Legend if Warrants are not immediately exercisable.]	 	[Prior to [●], Warrants evidenced by this Warrant Certificate cannot be exercised.]


 


EXERCISABLE ONLY IF COUNTERSIGNED BY THE
WARRANT AGENT AS PROVIDED HEREIN


 


VOID AFTER [●] P.M., [City] time,
ON [●].


 






    


    


    

 


BICYCLE THERAPEUTICS PLC

WARRANT CERTIFICATE REPRESENTING

WARRANTS TO SUBSCRIBE FOR

ORDINARY SHARES, NOMINAL VALUE £0.01 PER SHARE, INCLUDING

IN THE FORM OF AMERICAN DEPOSITARY SHARES


 


	No. [●]	 	[●] Warrants




 


This warrant certificate (the “Warrant
Certificate”) certifies that [●] or registered assigns is the registered owner of the above indicated number of
Warrants, each Warrant entitling such owner to subscribe for, at any time [after [●] p.m., [City] time, [on [●] and]
on or before [●] p.m., [City] time, on [●], [●] ordinary shares, nominal value £0.01 per share (the
 “Warrant Securities”), of Bicycle Therapeutics plc (the “Company”) on the
following basis: during the period from [●], through and including [●], the exercise price per Warrant Security will
be $[●], subject to adjustment as provided in the Warrant Agreement (as hereinafter defined) (the “Warrant Price”).
The Holder may exercise the Warrants evidenced hereby by providing certain information set forth on the back hereof and by paying
in full, in lawful money of the United States of America, [in cash or by certified check or official bank check in New York Clearing
House funds] [by bank wire transfer in immediately available funds], the Warrant Price for each Warrant Security with respect
to which this Warrant is exercised to the Warrant Agent (as hereinafter defined) and by surrendering this Warrant Certificate,
with the subscription form on the back hereof duly executed, at the corporate trust office of [name of Warrant Agent], or its
successor as warrant agent (the “Warrant Agent”), which is, on the date hereof, at the address specified
on the reverse hereof, and upon compliance with and subject to the conditions set forth herein and in the Warrant Agreement (as
hereinafter defined).


 


The term “Holder”
as used herein shall mean the person in whose name at the time this Warrant Certificate shall be registered upon the books to
be maintained by the Warrant Agent for that purpose pursuant to Section 4 of the Warrant Agreement.


 


The Warrants evidenced by this
Warrant Certificate may be exercised to subscribe for a whole number of Warrant Securities in registered form. Upon any
exercise of fewer than all of the Warrants evidenced by this Warrant Certificate, there shall be issued to the Holder hereof
a new Warrant Certificate evidencing Warrants for the number of Warrant Securities remaining unexercised.


 


This Warrant Certificate is issued under
and in accordance with the Warrant Agreement dated as of [●] (the “Warrant Agreement”), between
the Company and the Warrant Agent and is subject to the terms and provisions contained in the Warrant Agreement, to all of which
terms and provisions the Holder of this Warrant Certificate consents by acceptance hereof. Copies of the Warrant Agreement are
on file at the above-mentioned office of the Warrant Agent.


 


Transfer of this Warrant Certificate may
be registered when this Warrant Certificate is surrendered at the corporate trust office of the Warrant Agent by the registered
owner or such owner’s assigns, in the manner and subject to the limitations provided in the Warrant Agreement.


 


After countersignature by the Warrant
Agent and prior to the expiration of this Warrant Certificate, this Warrant Certificate may be exchanged at the corporate trust
office of the Warrant Agent for Warrant Certificates representing Warrants for the same aggregate number of Warrant Securities.


 


This Warrant Certificate shall not entitle
the Holder hereof to any of the rights of a holder of the Warrant Securities, including, without limitation, the right to receive
payments of dividends or distributions, if any, on the Warrant Securities (except to the extent set forth in the Warrant Agreement)
or to exercise any voting rights.


 






    


    


    

 


Reference is hereby made to the further
provisions of this Warrant Certificate set forth on the reverse hereof, which further provisions shall for all purposes have the
same effect as if set forth at this place.


 


This Warrant Certificate shall not be
valid or obligatory for any purpose until countersigned by the Warrant Agent.


 


In
Witness Whereof, the Company has caused this Warrant to be executed in its name and on its behalf by the facsimile
signatures of its duly authorized officers.


 


	Dated:	 	




 


	Bicycle Therapeutics plc, as Company
	 	 
	By:	 
	Name:	 
	Title:	 
	 	 
	 	 
	ATTEST:	 
	 	 
	 
	 

        COUNTERSIGNED

         

        [●], as Warrant Agent

	 	 
	By:	 
	Name:	 
	Title:	 
	 	 
	 	 
	ATTEST:	 
	 	 
	 	 	 	 


 






    


    


    

 


[REVERSE OF WARRANT CERTIFICATE]


 


(Instructions for Exercise of Warrant)


 


To exercise any Warrants
evidenced hereby for Warrant Securities (as hereinafter defined), the Holder must pay, in lawful money of the United States of
America, [in cash or by certified check or official bank check in New York Clearing House funds] [by bank wire transfer in immediately
available funds], the Warrant Price in full for Warrants exercised, to [●] [address of Warrant Agent], Attention: [●],
which payment must specify the name of the Holder and the number of Warrants exercised by such Holder. In addition, the Holder
must complete the information required below and present this Warrant Certificate in person or by mail (certified or registered
mail is recommended) to the Warrant Agent at the appropriate address set forth above. This Warrant Certificate, completed and
duly executed, must be received by the Warrant Agent within five business days of the payment.


 


(To be executed upon exercise of Warrants)


 


The undersigned hereby
irrevocably elects to exercise ______ Warrants, evidenced by this Warrant Certificate, to subscribe for _______ ordinary shares,
nominal value £0.01 per share (the “Warrant Securities”), of Bicycle Therapeutics plc and represents
that the undersigned has tendered payment for such Warrant Securities, in lawful money of the United States of America, [in cash
or by certified check or official bank check in New York Clearing House funds] [by bank wire transfer in immediately available
funds], to the order of Bicycle Therapeutics plc, c/o [insert name and address of Warrant Agent], in the amount of $_________
in accordance with the terms hereof. The undersigned requests that said Warrant Securities be in fully registered form in the
authorized denominations, registered in such names and delivered all as specified in accordance with the instructions set forth
below.


 


If the number of Warrants
exercised is less than all of the Warrants evidenced hereby, the undersigned requests that a new Warrant Certificate evidencing
the Warrants for the number of Warrant Securities remaining unexercised be issued and delivered to the undersigned unless otherwise
specified in the instructions below.


 


	Dated:	 	 	Name:	 







Please Print


 


	Address:	 
	 
	(Insert Social Security or Other
    Identifying Number
 of Holder)	 
	 
	Signature Guaranteed:	 	 
	 	Signature	 




 


(Signature must conform in all respects
to name of holder as specified on the face of this Warrant Certificate and must bear a signature guarantee by a FINRA member firm).


 


This Warrant may be exercised at the following
addresses: By hand at:


 


[●]


 






    


    


    

 


By mail at:


 


[Instructions as to form and delivery
of Warrant Securities and, if applicable, Warrant Certificates evidencing Warrants for the number of Warrant Securities remaining
unexercised—complete as appropriate.]


 






    


    


    

 


ASSIGNMENT


 


[Form of assignment to be executed
if Warrant Holder desires to transfer Warrant]


 


For
Value Received, ______________ hereby sells, assigns and transfers unto:


 


	 	 	 
	(Please print name and address including
    zip code)	 	Please print Social Security or other identifying
    number




 


the right represented by the within Warrant
to subscribe for _______________ shares of [Title of Warrant Securities] of Bicycle Therapeutics plc to which the within Warrant
relates and appoints ____________________ attorney to transfer such right on the books of the Warrant Agent with full power of
substitution in the premises.


 


	Dated:	 	 	 Name:	 







	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	 	Signature	 




 


(Signature must conform
in all respects to name of holder as specified on the face of the Warrant)


 


Signature Guaranteed