Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

PC Code: 006329

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Page 1 of 11 UNITED STATES ENVIRONMENTA L PROTECTION A GENCY

WASHINGTON, D.C. 20460 OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION

MEM ORANDUM Date: 25 - AUG - 20 10 SUBJECT: Acequinocyl. Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Section 3 Registration Action Use on Fruiting Vegetables, Hops, Okra, and Edible - Podded Beans. PC Code: 00632 9 DP Barcode: D369101 Decision No.: 417967 Registration No. : 66330 - 38 Petition No.: 9E7598 Regulatory Action: Section 3 Risk Assessment Type: Dietary Case No.: 7621 T XR No.: NA CAS No.: 57960 - 19 - 7 MRID No.: NA 40 CFR: §180.599 FROM : Sarah J. Lev y, Chemist

Risk Assessment Branch 1 (RAB1)/Health Effects Division ( HED; 7509P) THROUGH: Nancy

Dodd , Chemist David Soderberg , Chemist Dietary Exposure Science Advisory Council (DESAC) /HED (7509P) and George F. Kramer, Ph.D. , Branch Senior Scienti st Branch/Health Effects Division (7509P) TO: Sarah J. L ev y, Chemist/Risk Assessor

RAB1/HED (7509P) and Barbara Madden, RM 05 Registration Division ( RD; 7 505 P)Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Page 2 of 11 Executive Summary A chronic aggregate dietary (food and drinking water) exposure and ri sk assessment w as conducted using the Dietary E xposure Evaluation Model ( DEEM - FCID TM , Version 2.03 ) which use food consumption data from the U.S. Department of Agriculture’s Continuing Survey s of Food Intakes by

Individuals (CSFII) from 1994 - 1996 and 1998. The analysis was performed to support a requested Section 3 registration u se of the insecticide acequinocyl (2 - (acet yl oxy) - 3 - dodecyl - 1,4 - naphthalenedione) on f r uiting veg etables, h ops, o kra, and e dible - p odded b eans. An acute dietary

assessment was not conducted for acequinocyl because an endpoint of concern attributable to a single do se was not identified; therefore, an aRfD was not established. A cancer dietary assessment was not conducted because acequinocyl was classified as not likely to be carcinogenic to humans. Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization Tolerance - level residues and 100 percent crop treated (%CT) data were used in the chronic dietary assessment. DEEM  ver. 7.81 default processing factors were used with the exception of grape juice and raisins (see “Residue Information” S ection of this document for details). For the chronic dietary

assessment, the general U.S. population and all population subgroups have risk estimates which are not of concern to HED . The chronic dietary exposure estimate for the U.S. population is 9.8% of the chronic population - adjusted dose (cPAD). The highest exposed population subgroup (children 1 - 2 years old) occupies 4 5 % of the cPAD. The use of anticipated residues (ARs), empirical processing factors, and %CT would refine further HED’s exposure an d risk estimates ; however, refinement is not needed at this time. I. Introduction Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population - adjusted dose (PAD). The PAD is equivalent to point of departure (POD, NOAEL , LOAEL, e.g.) divided by the required uncertainty

or safet y factors. For acute and non - cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is generall y concerned when estimated cancer risk exceeds one in one m illion . References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21 - JUN - 2000, web link: http://www.epa.gov/fedrgstr/EPA PEST/2000/July

/Day - 12/6061.pdf

; or see SOP 99.6 ( 20 - AUG - 1999 ). The most recent dietary

risk assessment for acequinocyl was conducted by Sarah Lev y (11 - DEC 2007; DP# 347404 ).Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Page 3 of 11 II . Residue Information Under PP#9E7598, the Interregional Research Project No.4 (IR - 4), on behalf of the Agricultural Experiment Station s of AZ, CA, CO, FL, ID, NC, NJ, NY, OK, OR, TN, TX, VA, and WA, has submitted a petition proposing the use of acequinoc yl(Kanemite  15 soluble concentrate (SC), 1.25 lb/gal), a quinoline type of miticide, on fr uiting veg etables, h ops, o kra, and e dible - p odded b eans . Permanent tolerances are currentl y established under 40 CFR §180.599(a) for the combined residues of acequi nocyl and its metabolite , 2 - dodecyl - 3 - hydrox y - 1,4 - naphthoquinone, expressed as acequinocyl equivalents, in/on a number of plant and livestock commodities. Tolerances for plant commodities range from 0.02 ppm (tree nuts and pistachios) to 30 ppm (citrus oi l), and tolerances for livestock commodities are established at 0.02 ppm in the fat and liver of cattle, goat, horse, and sheep . There are residential uses (greenhouse, ornamental, etc.) for acequinocyl established as well. Note that for this petition, there are no livestock feedstuffs associated with the proposed crop uses; therefore , re - evaluation of the registered l ivestock tolerance levels is not necessary at this time . Based on the structural similarity of acequinocyl - OH to par ent and the presence of acequinocyl OH at quantifiable levels in crops, the HED Metabolism Assessment Review Committee (MARC) concluded that parent and acequinocyl - OH are the residues of concern for risk assessment and tolerance expression in apples, orang es, and eggplant commodities (Memo, S. Lev y, 07 - JAN - 2004; DP# 297872). For purposes of this petition, HED is willing to translate these results to hops and edible - podded beans as these two crops are low - consumption food items. See Table 1 for a summary o f the residues of concern determined by the MARC. Table 1. Residues of Concern in Crops, Ruminants, and Drinking Water. Matrix Tolerance Expression Residues for Risk Assessment Fruit Crops Acequinocyl + Acequinocyl - OH (R1) Acequinocyl + Acequinocyl - OH (R1) Ruminants Acequinocyl + Acequinocyl - OH (R1) Acequinocyl + Acequinocyl - OH (R1). In liver and kidney, also include AKM - 15. Rotational Crops N ot Determined * N ot Determined * Drinking Water NA ** Acequinocyl + Acequinocyl - OH (R1) * A confined rotationa l crop study has been revie wed and a 30 - day plant - back interval has been recommended (DP#351336, S. Levy, 6/25/08). ** NA = not applicable. Residue Data used for the Chronic Assessment: To l erance - level residues and 100%CT data were used in the chronic di etary assessment. DEEM  ver. 7.81 default processing factors were used with the exception of grape juice and raisins. As residues were reduced in both grape juice (<0.02x) and raisin (0.15x), separate tolerances are not required for these commodities; th erefore, the DEEM  ver. 7.81 default processing factors for juice and raisin were set to 1 as concentration was shown not to occur (Memo, S. Lev y, 05 - SEP - 2007; DP#: 342805 ) . The tolerance value of 0.02 ppm for cattle, goat, horse, and sheep fat and liver was entered for meat by products as well, where applicable.Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Page 4 of 11 The use of ARs, empirical processing factors, and %CT data would refine further HED’s exposure and risk estimates. However, refinement of the dietary exposure estimates is not needed at this time . See Table 2 for a summary of the data used in the chronic assessment. Table 2. Data and Residue Estimates Used in the Acequinocyl Chronic Dietary Analyses . Comm odity Data Source (M RID) %CT Processing Factors HED - Recommended Tolerance (ppm) Vegetable , fruiting, group 8 47819401, 4781940 2 100 NA 0.70 Okra 1 Translated NA 0.70 Bean, edible podded 4781940 3 NA 0.25 Hop, dried cones 47819404 NA 4.0 1 Okra has been recommended to be added as a member of the fruiting vegetable group 8; however, unt il okra has been officially added to the crop group, a separate tolerance is required for okra at the same tolerance level (0.70 ppm) as for fruiting vegetables. III. Drinking Water Data The drinking water residues used in the dietary risk assessment wer e provided by the Environmental Fate and Effects Division (EFED) ( I. Maher , 29 - A PR - 20 10 ; DP# 36 8426 ) and incorporated directl y into this dietary assessment. Water residues were incorporated directl y into DEEM - FCID under the food categories “water, direct, all sources” and “water, indirect, all sources.” Acequinocyl can reach surface water via spray drift and less likely

via runoff. Due to its high Kd values it is expected to exhibit low mobility in soil and low potential to leach into groundwater. Once a cequinocyl has entered surface water, it is not likely to persist as it will hydrol yz e to form hydrox y - acequinocyl (also known as OH - AKD 023, 2 - hydroxy - 3 - dodecyl - 1,4 - napthelenedione (HDNQ), and R - 1). There are no drinking water monitoring data available f or acequinocyl or its metabolite acequinocyl - OH (R1), the residues of concern . Groundwater and surface water estimated drinking water concentrations (EDWCs) were generated for acequinocyl using the Screening Concentration in Ground Water (SCI - GROW) and Pe sticide Root Zone Model/Exposure Analy sis Modeling S ys tem (PRZM/EXAMS) models, respectivel y. T wo approaches were used in performing the drinking water assessment for the proposed acequinocyl uses. In Approach #1, acequinocyl was conservatively assumed to be stable to all routes of degradation to account for the uncertainties associated with the environmental fate data. In Approach #2, total (acequinocyl + acequinocyl - OH) residues were modeled with the assumption that the metabolite acequinocyl OH (referr ed to as the R1 degradate in this assessment) is of toxicological concern. The highest PRZM - EXAMS surface water modeling estimates were obtained for the Pennsylvania tomato scenario for the chronic values. The modeled EDWCs for ground and surface water are summarized in Table 3 .Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Page 5 of 11 Table 3 . Ground and Surface Water EDWCs for Acequinocyl. Approach #1 and #2 Groundw ater EDWC for Acequinocyl + R1 (ppb) Surface Water Approach #1 Acequinocyl Approach #2 Acequinocyl + R1 1 - in - 10 - Y ear Chronic Mean Concentration (ppb) 1 - in - 10 - Y ear Chronic Mean Concentration (ppb) 0.00 36 2.45 0.29 Since the surface water EDWCs are higher than the groundwater EDWC, HED selected the surface water value for use in the chronic dietary assessment. The EDWC derived via Approac h #1 represents the upper - bound value (2.45 ppb) while that derived via Approach #2 represents the lower - bound value (0.29) . The 2. 45 ppb value was used in the dietary modeling as this value assures a conservative assessment . IV. DEEM - FCID TM Program and Consumption Information An a cequinocyl chronic dietary exposure assessment w as conducted using DEEM - FCID TM , Version 2.03 which incorporates consumption data from USDA’s CSFII, 1994 - 1996 and 1998. The 1994 - 96, 98 data are based on the reporte d consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g. , apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure a ssessment are retained as individual consumption events. Based on analy sis of the 1994 - 96, 98 CSFII consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the followi ng population subgroups: the general U.S. population, all infants (<1 ye ar old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, adults 20 - 49, females 13 - 49, and adults 50+ y ears old. For chronic dietary

exposure assessment, an estimate of the res idue level in each food or food form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estim ate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the c PAD. This procedure is performed for each population subgroup. V. Toxicological Information On 14 - OCT - 2003, the HED Hazard Identification Assessment Review Committee (HIARC) reviewed the recommendations of the toxicology reviewer for acequinocyl with re gard to the acute and chronic RfDs and the toxicological endpoint selection for use as appropriate in occupational/residential exposure risk assessments. The potential for increased susceptibility of infants and children from exposure to acequinocyl was a lso evaluated as required by the Food Quality Protection Act (FQPA) of 1996 under the 2002 OPP 10X Guidance. Table 4 is aAcequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Page 6 of 11 summary of the toxicology

doses and endpoints selected that are relevant to dietary exposure assessment (TXR# 0052234, 13 - NOV - 2003). T he acequinocyl risk assessment team confirmed that the endpoints selected previously remain appropriate . Table 4. Summary of Toxicological Doses and Endpoints for Acequinocyl for Use in Dietary Exposure Risk Assessment. 1 Exposure/ Scenario Point of

De parture Uncertainty/

FQPA Safety Factors RfD, PAD, Level of

Concern Study and Toxicological Effects Ac ute Dietary (General Population, including Infants and Children) N/A N/A N/A An endpoint of concern (effect) attributable to a single dose was not identified in the database. Quantification of acute risk to general population including infants and children is not required. Chronic Dietary (All Populations) NOAEL=

2.7 mg/kg/day UF A= 10x

UF H =10x FQPA SF= 1x cPAD = cRfD =

0.027 mg/kg/day 18 - mo nth carcinogenicity study in

mice; LOAEL=7.0 mg/kg/day based on clinical chemistry and microscopic nonneoplastic lesions (brown pigmented cells and perivascular inflammatory cells in liver) 1 UF = uncertainty factor, UF A = extrapolation from animal to human (interspecies), UF H = potential variation in sensitivity among members of the human population (intraspecies), FQPA SF = FQPA Safety Factor, NOAEL = no observed adverse effect level, LOAEL = lowest observed adverse effect level, RfD = reference dose (a = a cute, c = chronic), PAD = population adjusted dose, MOE = margin of exposure, LOC = level of concern, N/A = Not Applicable, UF DB = database uncertainty factor, UF L = uncert a i nty factor for lack of a NOAEL . VI. Results/Discussion As stated above, for a cute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM - FCID TM analy ses estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 5 are for the general U.S. Population, all infants (<1 y ear old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, femal es 13 - 49, adults 20 - 49, and adults 50+ years. An acute dietary assessment was not conducted for acequinocyl because an endpoint of concern attributable to a single dose was not identified; therefore, an a RfD was not established. A cancer dietary assessme nt was not conducted because acequinocyl was classified as not likely to be carcinogenic to humans. The chronic dietary

exposure assessment (using tolerance level residues and 100% CT information for all registered and proposed uses) was conducted for the general U.S. population and various population subgroups. Drinking water was incorporated directly into the dietary assessment using the chronic concentration for ground water generated b y the PRZM/EXAMS model. This assessment concludes that the chronic dietary exposure estimates are not of concern to HED for the general U.S. population ( 9.8 % cPAD) and all population subgroups. The most highl y exposed population subgroup is children 1 - 2 years old at 4 5 % of the cPAD. The use of ARs, empirical processing factors, and %CT data would refine further HED’s exposure and risk estimates ; however, refinement is not needed at this time .Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Page 7 of 11 Table 5 . Summary of Dietary (Food and Drinking Water) Exposure and Risk for Acequinocyl . Population Subgroup Chronic Dietary 1 Dietary Exposure (m g/kg/day) % cPAD U.S. Population (total) 0.00 2657 9.8 All Infants (< 1 year old) 0.005 584 21 Children 1 - 2 years old 0.012 193 4 5 Children 3 - 5 y ears old 0.00 8046 30 Children 6 - 12 y ears old 0.003 657 14 Youth 13 - 19 y ears old 0.001 85 5 6.9 Adults 20 - 49 y ears old 0.001 758 6.5 Adults 50+ years old 0.001 811 6.7 Females 13 - 49 y ears old 0.00 1808 6.7 1 Chronic dietary endpoint of 0.0 27 mg/kg/day applies to the general U.S. population and all population subgroups . T he values for the high est exposed population for each type of risk assessment should be bolded . V II. Conclusions A chronic dietary

exposure and risk assessment w as conducted for the proposed food use s and permanent tolerances of acequinocyl, including potential exposure from drinking water. The chronic dietary

(food + drinking water) exposure to acequinocyl is below HED’s level of concern for the general U.S. population and all population subgroups. The chronic dietary exposure utilized 9.8 % cPAD for the general U.S. popul ation and 45 % of the cPAD for children 1 - 2 years old, the most highl y exposed population subgroup. An acute dietary assessment was not conducted for acequinocyl because an endpoint of concern attributable to a single dose was not identified; therefore, an aRfD was not established. A cancer dietary assessment was not conducted because acequinocyl was classified as not likely to be carcinogenic to humans. VIII . List of Attachments Attachment 1: Chronic Food plus Drinking Water Residue Input File. Attachment 2: Chronic Results File.

cc: I. Mah er (EFED /ERBI; 7507P ) RDI: DESAC ( 19 - MAY - 2010) ; G.F. Kramer ( 24 - MAY - 2010) S. Levy:S10953:PY1:(703)305 - 0783:7590PAcequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Page 8 of 11 Attachment 1: Chronic Food plus Drinking Water Residue Input File. U.S. Environmental Protectio n Agency Ver. 2.00 DEEM - FCID Chronic analysis for ACEQUINOCYL 1994 - 98 data Residue file: C: \ Documents and Settings \ slevy \ Desktop \ Acequinocyl \ 006329c.R98 Adjust. #2 used Analy sis Date 05 - 26 - 2010 Residue file dated: 05 - 26 - 2010/09:02:01/8 Reference dose (RfD) = 0.027 mg/kg bw/day Comment:No acute dietary endpoint; not carcinogen. cRfD=cPAD

---------------------------------------------- ------------------------------- Food Crop Residue Adj.Factors Comment EPA Code Grp Food Name (ppm) #1 #2

-------- ---- ---------------------- ---------- ------ ------ ------- 14000030 14 Almond 0.020000 1.000 1.000 14000031 14 Almond - babyfood 0.020000 1.000 1.000 14000040 14 Al mond, oil 0.020000 1.000 1.000 14000041 14 Almond, oil - babyfood 0.020000 1.000 1.000 11000070 11 Apple, fruit with peel 0.400000 1.000 1.000 11000080 11 Apple, peeled frui t 0.400000 1.000 1.000 11000081 11 Apple, peeled fruit - babyfood 0.400000 1.000 1.000 11000090 11 Apple, dried 0.400000 8.000 1.000 11000091 11 Apple, dried - babyfood 0.400000 8.000 1.000 11000100 11 Apple, juice 0.400000 1.300 1.000 11000101 11 Apple, juice - babyfood 0.400000 1.300 1.000 11000110 11 Apple, sauce 0.400000 1.00 0 1.000 11000111 11 Apple, sauce - babyfood 0.400000 1.000 1.000 06010430 6A Bean, snap, succulent 0.250000 1.000 1.000 9E7598 06010431 6A Bean, snap, succulent - babyfood 0.250000 1.000 1.0 00 9E7598 21000460 M Beef, meat byproducts 0.020000 1.000 1.000 21000461 M Beef, meat byproducts - babyfood 0.020000 1.000 1.000 21000470 M Beef, fat 0.020000 1.000 1.000 2100 0471 M Beef,fat - babyfood 0.020000 1.000 1.000 21000490 M Beef, liver 0.020000 1.000 1.000 21000491 M Beef, liver - babyfood 0.020000 1.000 1.000 14000590 14 Brazil nut 0.020000 1.000 1.000 14000680 14 Butternut 0.020000 1.000 1.000 14000810 14 Cashew 0.020000 1.000 1.000 14000920 14 Chestnut 0.020000 1.000 1.000 10001060 10 Citrus citron 0.200000 1.000 1.000 10001070 10 Citrus hybrids 0.200000 1.000 1.000 10001080 10 Citrus, oil 30.0 00000 1.000 1.000 11001290 11 Crabapple 0.400000 1.000 1.000 08001480 8 Eggplant 0.700000 1.000 1.000 9E7598 14001550 14 Filbert 0.020000 1. 000 1.000 14001560 14 Filbert, oil 0.020000 1.000 1.000 23001710 M Goat, fat 0.020000 1.000 1.000 95001750 O Grape 1.600000 1.000 1.000 95001760 O Grape, juice 1.600000 1.000 1.000 95001761 O Grape, juice - babyfood 1.600000 1.000 1.000 95001770 O Grape, leaves 1.600000 1.000 1.000 95001780 O Grape, raisin 1.600000 1.000 1.000Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Page 9 of 11 95001790 O Grape, wine and sherry 1.600000 1.000 1.000 10001800 10 Grapefruit 0.200000 1.000 1.000 10001810 10 Grapefruit, juic e 0.200000 2.100 1.000 14001850 14 Hickory nut 0.020000 1.000 1.000 95001880 O Hop 4.000000 1.000 1.000 9E7598 10001970 10 Kumquat 0.200000 1.000 1.000 10001990 10 Lemon 0.200000 1.000 1.000 10002000 10 Lemon, juice 0.200000 2.000 1.000 10002001 10 Lemon, juice - babyfood 0.20000 0 2.000 1.000 10002010 10 Lemon, peel 0.200000 1.000 1.000 10002060 10 Lime 0.200000 1.000 1.000 10002070 10 Lime, juice 0.200000 2.000 1 .000 10002071 10 Lime, juice - babyfood 0.200000 2.000 1.000 11002100 11 Loquat 0.400000 1.000 1.000 14002130 14 Macadamia nut 0.020000 1.000 1.000 08002340 8 Okra 0.700000 1.000 1.000 9E7598 10002400 10 Orange 0.200000 1.000 1.000 10002410 10 Orange, juice 0.200000 1.800 1.000 10002411 10 Oran ge, juice - babyfood 0.200000 1.800 1.000 10002420 10 Orange, peel 0.200000 1.000 1.000 11002660 11 Pear 0.400000 1.000 1.000 11002661 11 Pear - babyfood 0.400000 1.000 1.000 11002670 11 Pear, dried 0.400000 6.250 1.000 11002680 11 Pear, juice 0.400000 1.000 1.000 11002681 11 Pear, juice - babyfood 0 .400000 1.000 1.000 14002690 14 Pecan 0.020000 1.000 1.000 08002700 8 Pepper, bell 0.700000 1.000 1.000 9E7598 08002701 8 Pepper, bell - babyfood 0.700000 1.000 1.000 9E7598 08002710 8 Pepper, bell, dried 0.700000 1.000 1.000 9E7598 08002711 8 Pepper, bell, dried - babyfood 0.700000 1.000 1.000 9E7598 08002720 8 Pepper, nonbell 0.700000 1.000 1.000 9E7598 08002721 8 Pepper, nonbell - babyfood 0.700000 1.000 1.000 9E7598 08002730 8 Pepper, nonbell, dried 0.700000 1.000 1.000 9E7598 14002820 14 Pistachio 0.02000 0 1.000 1.000 10003070 10 Pummelo 0.200000 1.000 1.000 11003100 11 Quince 0.400000 1.000 1.000 26003400 M Sheep, meat byproducts 0.020000 1.000 1 .000 26003410 M Sheep, fat 0.020000 1.000 1.000 26003411 M Sheep, fat - babyfood 0.020000 1.000 1.000 95003590 O Strawberry 0.400000 1.000 1.000 95003591 O Strawberry - babyfood 0.400000 1.000 1.000 95003600 O Strawberry, juice 0.400000 1.000 1.000 95003601 O Strawberry, juice - babyfood 0.400000 1.000 1.000 10003690 10 Tangerine 0.200000 1.000 1.000 10003700 10 Tangerine, juice 0.200000 2.300 1.000 08003740 8 Tomatillo 0.700000 1.000 1.000 9E7598Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Page 10 of 11 08003750 8 Tomato 0.700000 1.000 1.000 9E7598 08003751 8 Tomato - babyfood 0.700000 1.000 1.000 9E7598 08003760 8 Tomato, paste 0.700000 1.000 1.000 9E7598 08003761 8 Tomato, paste - baby food 0.700000 1.000 1.000 9E7598 08003770 8 Tomato, puree 0.700000 1.000 1.000 9E7598 08003771 8 Tomato, puree - babyfood 0.700000 1.000 1.000 9E7598 08003780 8 Tomato, dried 0.700000 1.000 1.000 9E7598 08003781 8 Tomato, dried - babyfood 0.700000 1.000 1.000 9E7598 08003790 8 Tomato, juice 0.700000 1.000 1.000 9E7598 14003910 14 Walnut 0.020000 1.000 1.000 86010000 O Water, direct, all sources 0.002450 1.000 1.000 86020000 O Water, indirect, all sources 0.002450 1.000 1.000Acequinocyl Dietary Exposure and Risk Assessment DP# 369101

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Page 11 of 11 Attachment 2: Chronic Results File. U.S. Environmental Protection Agency Ver. 2.00 DEEM - FCID Chronic analysis for ACEQUINOCYL (1994 - 98 data) Residue file name: C: \ Documents and Settings \ slevy \ Desktop \ Acequinocyl \ 006329c.R98 Adjustment factor #2 used. Analysis Date 05 - 26 - 2010/09:02:22 Residue file dated: 05 - 26 - 2010/09:02:01/8 Reference dose (RfD, Chronic) = .027 mg/kg bw/day COMMENT 1: No acute dietary endpoint; not carcinogen. cRfD=cPAD

====== ======================================================================= Total exposure by population subgroup

----------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

------ -------------------------------- ------------- --------------- U.S. Population (total) 0.002657 9.8% U.S. Population (spring season) 0.002596 9.6% U.S. Population (summer season) 0.002685 9.9% U.S. Population (autumn season) 0.002656 9.8% U.S. Population (winter season) 0.002692 10.0% Northeast region 0.003098 11. 5% Midwest region 0.002605 9.6% Southern region 0.002340 8.7% Western region 0.002822 10.5% Hispanics 0.002932 10.9% Non - hispanic whites 0.002630 9.7% Non - hispanic blacks 0.002535 9.4% Non - hisp/non - white/non - black 0.002797 10.4% All infants (< 1 year) 0.005584 20.7% Nursing infants 0.002797 10.4% Non - nursing infants 0.006642 24.6% Children 1 - 6 yrs 0.008946 33.1% Children 7 - 12 yrs 0.003387 12.5% Females 13 - 19 (not preg or nursing) 0.001912 7.1% Females 20+ (not preg or nursing) 0.001808 6.7% Females 13 - 50 yrs 0.001991 7.4% Females 13+ (preg/not nursing) 0.001997 7.4% Females 13+ (nursing) 0.002049 7.6% Males 13 - 19 yrs 0.001787 6.6% Males 20+ yrs 0.001738 6.4% Seniors 55+ 0.001830 6.8% Children 1 - 2 yrs 0.012193 45.2% Children 3 - 5 yrs 0.008046 29.8% Children 6 - 12 yrs 0.003657 13.5% Youth 13 - 19 yrs 0.001855 6.9% Adults 20 - 49 yrs 0.001758 6.5% Adults 50+ yrs 0.001811 6.7% Females 13 - 49 yrs 0.001808 6.7%

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