90 DAY INHAlATION TOXICIT STUDY IN TIlE RAT WITH RECOVER.Y PHASE 

APPENDIX 6 .. INDIVIDUAL FUNCTIONAL OBSERVATIONAL BAnERY (LANDING FOOT SPLAY, TlME TO TAIL-FLICK, 


FORE· AND HIND-LIMB GRIP STRENGTH) 


caour• 01 DOSII LII9IIL. o W- a_nu.... 

a.£ 

., CUll FIIIIUa'I IJO _au. DJIW12 

.. 6 61 600 

• 6 " 310 

.. 6 70 n!l 

RBGULATORY/REPOR.T - 197 

90 DAY INHALATION TOXICI'Y STUDY IN TIlE RAT wrm RECOVERY PHASE 

APPENDIX 6 -INDIVIDUAL FUNCnONAL OBSERVATIONAL BATTERY (LANDING FOOT SPLAY, TIME TO TAiL-FUCI(, 


FORE.. AND HIND-UMB GRIP STRENGTH) 


GIIII9I, 01 

B:I'I. CAR ...

-

DOIDI Y'fJIL. 

IIJIIII: 

100 PJi1II ..GIIU ...... If 

JIO ...Dar. 12 

1 , 11 e211 

, 12 5&0 

, 13 500 

1 , 14 100. 

1 II lIS 510 

:J 10 11 US 

1 10 17 410 

1 10 Ie 47!1 

10 I' 57S 

31 10 20 400 

I'I:IIALII 

aBl:DL 

Z 11 71 450 

a 11 12 450 

Z 11 73 .50 

1 11 74 325 

11 11 675 

, 
 12 450 

, " 12 77 450 

REOUtATORY!REPORT - 198 
90 DAY INHAlATION TOXIcrv STUDY IN THE RAT WITH RECOVER.Y PHASE 

APPENDIX 6 - ..DIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY (LANDING FOOT SPLAY, TIME TO TAIL-FLICK, 


FORE- AND HIND-UMB GRIP STRENGTH) 


..,1. GIIOCIP. 02 CIiGB J.....a 

D08II LInlIL. 

_ 

1110 PIlI .. ClUJ' ........ 

110 110 UlIQL 12 

41 13 ,. 131 

, 12 7t .50 

, 12 10 1$00 

REGUlATORYIREPORT· 199 
90 DAY INHALATION TOXICfY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 6 - INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY (LANDING FOOT SPLAY, TIME TO TAiL-FUCK, 


FORE- AND HIND-UMB GRIP STRENGTH) 


a:ovP ,03 DOSa LIIV1Do. 300 lis­ m.anaaD188 • 

IlDL 

.0 CUB...... 110 lUIDIUo .... 12 

<I 11 II 500 

" 11 I. <671 

<I 111 90 1525 

'REGUlATORY/REPORT • 201 
90 DAY INHALATION TOXICTY STUDY IN nlERAT WIrH RECOVERY PHASE 

APPENDIX 6 -INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATrERY (LANDING FOOT SPLAY, TIME TO TAiL-FUCK, 

FORE· AND HIND-UNB GRIP STRENGTH) 

a:H01'. 03 DOIIII JonB,.

- 300 ,.". .. al:l U .... S 

UK CUll IfUJI: 

110 110 UIIIDL 12 

1 n a1 110 

13 2:1 421 

1 U a3 sas 

13 :14 UI 

U 25 600 

.3 14 II SSO 

II 14 21 US 

3 14 H 550 

3 U n 500 

3 14 :SO 610 

IIIIIaLII 

.llflJD£ 

a 1$ u &'71 

3 U 82 32' 

2 11 U SSO 

2 IS 84 4l1l 

2 	 IS ., 31' 

111 II iso " 

t 	 ., II 600 

RBOULATORY/REPORT • 200 

90 DAY INHALATION rOXICIY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 8 - INDMDUAl.. FUNCTIONAL OBSERVATIONAL BATTERY (LANDING FOOT SPLAY, nUE TO TAIL-FUel<, 


FORE· AND HIND-LIMB GRIP STRENGTH) 


G'IOUP. 04 DOG: LIIYIIl'o I 1000 PIll .. GIlD UllIN • ..... CAGI ~ ....... 
 JIO JIO .u:nar. 12 

1 17 31 525 

1 17 32 221 

1 11 33 aoo 

1 11 350 " 

1 11 35 675 


3 1$ 3. 6.0 


3 10 37 500 


3 1. 3. 321 


3 10 n SSO 


3 11 625
 "'0 

....... 


.IiIIDII.r. 


2 21 t1 US 


2 21 n 
 ... 2 21 SSO " 

2 21 .4 375 

2 21 .S 65. 

4 22 .11 1111 

4 2:1 ., .so 

fREGULATORY/REPORT - 202 
90 DAY INHALATION TOXICTY STIIDY IN TIlE RAT WITH RECOVERY FHASE 

APPENDIX 6 -INDIVIDUAL FUNCTIONAL OBSERVAnONAL BATrERY (LANDING FOOT SPLAY, TIME TO TAIL-Fuel(, 


FORE- AND HIND-UMB GRIP STRENGTH) 


6JIJOI'1 0" DOIIII LIYIILt 1000 :IiIs- lilt all'''''' • 

IIDL CIQ,.....,. ... _ 110 AJDaL 1:1 

• 22 ,. 350 

• aa " 5715 

• 22 100 1525 

'REGULATORY/REPORT - 203 

90 DAY INHALATION TOXICl'Y STUDY IN THE RAT WIllI REroVERY PHASE 

APPENDIX 6 • INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATIERY (LANDING FOOT SPLAY, TIME TO TAIL-FLICK, 


FORE· AND HIND-UMB GRIP STRENGTH) 


IIUL

., ~. 01 

c:aa IIIl.II ., - IIOBI: LaSL.

... 12 

0 ~ no au.usua • 

1 1 1 1125 

1 1 2 850 

1 1 :I 700 

;I. 1 '" 780 

1 1 5. 1400 

:I 2 & 700 

I :.J. 7 1575 

J :.J. • 10.0 

:I :.J. • 185• 

3 2 10 1175 

I!'IIf.I.LII 

.IIJDIU, 

2 5. 61 100. 

2 5. ca 1350 

a 5 13 700 

2 5 U la5 

2 5 ~5 675 

,
 -4 ISO 

, " 
 C7 1471 '" 

iREGULATORY/REPORT - 204 
90 DAY INHA.LATION TOXICfY STUDY IN TImRAT WITH RECOVERY PHASE 

APPENDIX 6 - INDIVIJUAL FUNCTIONAL OBSERVATIONAL BAlTERY (LANDING FOOT SPLAY, TIME TO TAIL-FLICK, 


FORE- AND HIND-UIIB GRIP STRENGTH) 


QIOUF. 01 D08II 1oIVJIL. o filii no 8'....... II 

IIIDr. 

III) 

CAIa rau.s

.,.:na.r. _ 12 

4 , ,. 1100 

, ,. .00 

f , 70 671 

'REGUlATORY/REPORT • 205 
90 DAY INHALATION TOXICfY STUDY IN THE RAT WlTIf RECOVERY PHASE 

APPENDIX 6 • INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY (LANDING FOOT SPLAY, TIME TO TAil-FUel<, 


FORE· AND HIND-UMB GRIP STRENGTH) 


CiIIOUP. 02 DCMm r.nar.. 100 PPI n.D..I....... • IIDL c.a.ca: IAI'.I: IIIIIIIC 

10 JIO AIIDIat. 12 

1 , 1, 1125 

1 , 12 750 

1 • 13 02111 

1 I It 1:100 

1 I 15 121 

~ 10 16 025 

" 10 17 725 

3 10 U 725 

3 10 11 1:1211 

3 10 20 12110 

J'aALII: 


AIIDIIoL 


2 11 71 650 


2 11 72 1100 


2 11 7J 121 


2 11 7" 121


2 11 7$ '10 

" 
 1:1 76 1100 


12 no " " 

'RBOUlATORY!REPORT - 2O'i 
90 DAY INHALATION TOXIcrY STUDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 8 -INDMDUAL FUNCTIONAL OBSERVATIONAL BATTERY (LANDING FOOT SPLAY, TIME TO TAiL-FUCK, 

. FORE· AND HIND·LlMB GFlP STRENGTH) 

G1IllVJI. 02 DOUi uvm.. 100 ~ rr. cal1'....... lJ 

_. QQII.....u.B DB 

II) 110 AlIJMIL 12 

12 7. 1075 

12 n 1121 

12 •• "5 

REGUlATORY/REPORT - 200 
90 DAY INHAlATION TOXICTY STUDY IN TEE RAT WITH RECOVERY PHASE 

APPENDIX 6 - INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY (LANDING FOOT SPLAY, TIME TO TAiL-FUeK, 


FORE· AND HIND-UMB GRIP SlRENGTH) 


1tID'r.

., 

GIIOIIP. 03 

CI8I IIlU.lI

., lUIJIGL 

J)Otg r.rnrr...

... 

12 

300 ppa rr. au U8aIIS I 

1 13 :u liS 

1 13 aa 700 

1 13 U 1575 

1 13 U 6'75 

1 l! as '1'25 

3 14 16 .,0 

3 14 27 UOO 

3 14 all 1000 

3 14 21 lta5 

3 14 30 1375 

J'IIIU.B 


MDIU. 


:a 11 11 110 


:I 15 12. 6110 


:z 15 13 1300 


I 15 If. 1100 


2. 15 15 775 

.. 1. 16 1351 

.. l' 17 U5C

REGULATOllY/REPORT - 208 
90 DAY INHALATION TDXICfY sruDY IN THE RAT wrm RECOVERY PHASE 

APPENDIX 6 -INDIVIDUAL FUNCnONAL OBSERVATIONAL. BATTERY (lANDING FOOT SPLAY, TIME TO TAIL-FLICK, 


FORE- AND HIND-UMB GRIP STRENGTH) 


cat!OVI'. OJ IlOIJB Ln1IL. 300 ,.. no DIP _ • 

IIlDL QID FIIIU.Ii __ 

110 IfO -'11%..... 1:1 

;I 16 •• 13100 

t 16 •• III. 

t 16 .0 1000 

IREGULATORY/REPORT - 200 

•• 

90 DAY lNHALATION TOXICI'Y STUDY IN THE RAT WllH RECOVERY PHASE 

APPENDIX 6 -INDIVIDUAL FUNCTIONAL OBSERVATIONAL BAnERY (LANDING FOOT SPLAY, TIME TO TAiL-FLlCK, 


FORE· AND HIND-UMB GRIP STRENGTH) 


un.

.. GIl(JUP, Ot 

CAR IIIU 

110 JllDIAL 

DOIIII LIVIIL I

-U 

JO•• ". rr. an ...... g 

17 :S1 1.0 

n 32 121 

1 11 311 110. 

1 11 3t 77& 

11 35 70. 

10 U 700 

II 37 12.. 

3 18 III 1200 

3 II n 10.0 

3 11 .0 11.0 

JIIIIUJI 

JmII&L 

a 21 .1 521 

a 21 .2 .21 

2 21 n 97' 

lI:l .as 

:I :u ., 117• 

, :n 9. lUI 

.. 12 97 ISO 

lREGULATORY/REPORT • 210 
90 DAY INHALATION TOXIcrY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 6 - INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY (LANDING FOOT SPLAY, TIME TO TAIL-FLICK, 


FORE· AND HIND-LIMB GRIP STRENGTH) 


CIIOQr. ., DOIDI LIIYKL. 100. PI'II I'to an UUU It 

IDI. eMil ~ ... 110 110 UDIlL 12 

, 22 9' 675 

, 22 '9 9'711 

, 22 10. .all 

'REOULATOllY/REPOllT - 211 
90 DAY INHAlATION TOXJCTY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 6 • INDIVIDUAL FUNCTIONAL OBSERVATIONAL BAlTERY (LANDING FOOT SPLAY, TillE TO TAIL-FLICK, 


FORE- AND HIND-UMB GRIP STRENGTH) 


OIOVI'. 01 DOH .rnn:.. o P1III aa. au.. 

a'L 

110 

C&GIt 

110 AIIIIIlIL 110 __ 110 -------------------------­ eo •• I: • 'I' I ------••••••--.--••••••- ••­

1 J t 12 'I'IIIIID OU'I' ... 2 '7 12 'I'tIIID OU'I' 

REGULAIDRY/REPORT • 212 

90 DAY INHALATION TOXICI'Y STUDY IN THE RAT 1VITH RECOVERY PHASE 


APPENDIX 6 .. INDIVIDUAL FUNCTIONAL OasERVA110NAL BATTERY (LANDING FOOT SPLAY, TIME TO TAiL-FUeK, 

FORE.. AND HIND-UMB GRIP STRENGTH) 

.... QlI DOIUlIdlftl.. 3QO .... sa. ..... 

"DIJ'l, CIGlI ..... IIDDt --------------•.------.-- co 11 It ... 't I --_.-•••••---------.------­ ., ., 110 Il1O 

;, ]A 26 la !n.D 0IIIIt .. U ,_0IIft' 

RE.OUI.ATDRY/tlEPORT - 213 
90 DAY INHAlAll0NTOXlCJY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 6 - INDIVIDUAL FUNCTIONAL OBSERVATIONAL BATTERY (LANDING FOOT SPLAY, TIME TO TAIL-FLICK, 


FORE· AND HIND-UMB GRIP STRENGTH) 


iIi1IOD. ot IXMlB LSftL. 1000 ... lUI IIIIr.II 

IB1't. 

WI) 

CUll 110 AIr.JIAL 

.. DIIJI: JIll ----.-.-----------------•• CO •• II • l' I --------------------------­

1 17 31 12 'llIIID 00'1' 

REGUlATOIlY/REPORT - 214 
90 DAY INHAlATION TOXICI'Y STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 6 - INDIVIDUAL FUNCTIONAL OBSERVATIONAL BAlTERY (LANDING FOOT SPLAY, TIME TO TAiL-FUCK, 


FORE- AND HIND-UMB GRIP STRENGllt) 


IIIOUP. OJ DOa LIIVIIr.. o ... .Ilh ........ 

HP.. 

., CMlII 10 

MDIAL 

10 _ 110 •••- ••-••••----.---------. COli .. II • " • ----••••---••----•••••••••• 

a I 63 1:1 fJlD:l) on , 6 66 1:1 fJlD:l) on 

REGUlATORY/REPORT • 215 
90 DAY INHALATION TOXICl'Y STUDY IN THE RAT wrm: RECOVERY PHASE 

APPENDIX 8 - INDMDUAL FUNCTIONAL OBSERVATIONAL BAlTERV (LANDING FOOT SPLAy' TIME TO TAiL-FUCK, 


FORE-AND HIND-UMB GRIP STRENGTH) 


CIlOID. 113 DOSIr LIIYJIL. sao ~ OZa rJIIIIN'dI: 

Dl'L 

.., 

~GII 

., 

AIIIJI:AL 

110 

_ 

110 .---.--..---.---••-.•-.-.- co •••• ~ • -.•-­ •••-•••••.•-----.----­

, " .7 12 ~_OUT 

IREGULATORY/RBPORT - 216 

90 DAY INHALO\TION TOXICfY STUDY IN TIlE RAT WI11I RECOVERY PHASE 

c' APPENPIX 6 • INDIVIPUAL FUNCTIONAL OBSERVATIONAL BATTERY (LANDING FOOT SPLAY, TIME TO TAiL-FueK, 

FORE· AND HIND-UMB GRIP STRENGTH) 

WIOVI' • 0.. IXl8JI IJIVIIL I 1000 ppa IU. I'IIIDJ,JI 


UI'L (l1.GII AJIDIaL _ -------.---•• ---.---.----- Co 0 •••• I' I .------•• -------------. __ .­ ., 110 110 110 

Z 21 U U 'fDIIII) OUI' 


.. 22 " 11 'fDIIII) OUI' 


REGUlATORY/REPORT • 217 
90 DAY INHAIATION TOXlCIY STUDY IN TIlE RAT WITH RECOVERy PHASE 

APPENDIX 7 - INDMDUAL FUNCTIONAL OBSERVATIONAL BATTERY (MOTOR ACTIVITY) 

Key: 

NO. - number 

MINS- minutes 

IREGULATORY/REPORT - 218 

90 DAY INHALATION TOXICI'Y STUDY IN TIlE RAT Wl11I RECOVERY PHASE 

APPENDIX 7 - MOTOR ACTIVITY (MOVEMENTS /5 MINUTES) 

-. 	12 

a<M!J'. 1 DOD: LI9IIL. 0 ... 	 1IJIlI:• UL.D 

• DleD (IOD) 

gnu. 110. 1-5 6-10 11-15 16-20 21-25 2'-3' 31-35 31-10 41·" '6-50 

1 71 101 ., 17 51 11 10 n 7. 51 


2 11 71 II n 13
 ". ." 'I 'I 3 	 U 73 .0 71 

,. 13 ••

II 12 

I 107 '" 111 111 111 10' " 11' U7 120

S 	 12 71 75 71 67 15 11 77 


11 17 21 27 75 '3 11 10
 , " '" "7 	

22 

7 	 .,. ,. 10 21 2. SI 15 " 

I' 

II II 73 

II 32 $I 21 117 52 13 •, 	 '1 " 73 ." 'I II , 10 '6 

.. 9$ II I. 

10 .5 t3 11 13 I 11 II I' 	 I' " 

IREGULATORY/REPORT - 219 

90 DAY INHALATION TOXICI'Y STUDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 7· MOTOR ACTlVITY fMOYEMENTS /5 MINUTES) 

-. 12 

GIOUrr 2 DOell LllYllLr lOG ... az. 1IUoII8 

JDXOD (1IIJI8, 

Ular. 110. 1-5 '·10 11-11 U-:30 21-111 2'-30 11-35 31-"0 U-'" "·50

11 .2 17 ,. II 77 7. 13 11 .. 10 

12 ., 12 13 51 U 51 <II 72 .. 0 22 

13 7' 71 13 72 77 lot II II ... l' " 76 67 111 57 12 n 11 15 112 11 '7 77 II II '7 67 1011 

11 .. I 452 10 n 453 745 51 U 17 77 71 71 11 I 1 10 '7 

" " " 

''I ., " 

11 II II ., n .1 5' " ..

12 " I 14 111 11 75 II 72 75 31 21 '7 

2. 51 711 12 I. n IS 71 71 II n 

• " 

RBGUlATORY..ttBPORT • 220 
90 DAY lNHALATIONTOXICfY STUDY IN THE RAT WiTH RECOVER.Y PHASE 

APPENDIX 7· MOTOR ACTMTY (MOVEMENTS /5 MINUTES) 

..... 12 

., GIIIOIIIJ' • IlOiID LIYBL. SOD HII au. DLD ,..:1_ {tmaI) 

AIIJIIAL 110. 1-5 6-10 11-U 16-20 21-21 26·3\\ 31-35 3f-". 41....11 ,,'.5. 

21 51 64 70 416 IiIIi 51 61 63 7iii 

22 73 12 .,

I' U U 34 .... :17 15 

.,

60

23 77 .S 44 .. .. 22 12 ,U 12 10 " .0 u

'f 

7. n ... 15 . 


2' 16 70 1105 411 7l 1. 14 


25 "51 " flli 61 .,

77 "77 71 ..

7Z ,.. Z7 II 71. '0 17 U " 12 •• 

:ae 7G fa 12 " 21 " 4 12 36 f 

"

,. 7 :II 

2' 

at 51 61 S6 67 I. n 21 

SO 70 .. "75 .. 2. 

"

, 17 • 62 75 

~GULA10RY~PORT - 221 
I 

~ 

§ ~ ..

.. 
 z .. :=t - .. :I 

.. . ~ 1ft - T (/I ..

... ... ~ Z 

W .. I

~ :a ..· 

W ~ 

e5 ~ ...., !. I ..•

.., ~ ~ i E :E ...., 

.. 

H · § 

E-< ~ i It .... ... e H

0 

8

:IE I 

•.. I • .. ..... ...· 

>­

C§ ~ Q E = .. ~. • ..

I 

Z 

w 

:

.. Q. ... .. • ~ I

.. ~ ., I I

... 

...

.. .. i 

• ~=:;!=::I=~.: 

.. ~~=:t$~~==, 

.. .........:o...tIt· .. 
 ~....... .. • ~:~:a ..=:::... 

......:0••:: .... .,....po ~....,., .... 

:r;::;·::B· 

.. ................:. 
 ...."' ••fllWI ... 

........ ·..1'....... .. .......:: 
 ...


"' .. "'''' ........ 111.
 .......-. ...-. ... : . 

........ 10 ....... ..,
 ............... 


I ~~:::::=:;'u:

i I 

~ 

t; 

0 

~ ~ 

~ ; 

90 DAY INHALATION TOXlCI'Y STUDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 7 - MOTOR ACTIVITY (MOVEMENTS /5 MINUTES) 

..a. 

GIlOIIIl'I 

12 

1 DOIR 10_. o .IM BU. I'IIICI.LJIII 

HlIOU (IIDII) 

UlDIU 110. 1-5 '-10 11-111 16-210 21-21 2'-3. 31-. "-'0 41-45 ',"'0 

'1 

62 

63 

73 

12 

6. 

104

,.

,. 7!1 

71 

111 

71 

17

.. .5

,. 

66 

77

.. 

n 

1<1 

.2 

1<1 

0 

.'7 

77 

1 

15 

62 

71 

n 

15 6fo .0 7. " n 17 73 72 62 lit '70 

" " 

"

,. 

6. 

7. 

II 

76 

lit 

n 

113 

75 

76 

ta 

Ia 

.0 

IS

., 

17 

13 

"

,. 

77 

77 

a7 

" 66 

'2 

" 71 

t. 

16 

II. 

U 

.3

, 

32 

• 1 

n 

0 

77 

" 

52

,. 

•

0

.. 

" 

.0

•

6' 

1 

71 

" 

.2 

1 

" 0 

a7 

102 

73 

61 

aa 

2. 

n 

72 

REGUlATORY/REPORT - 223 
•• 

90 DAY INHALATIO~ TOXICTY STUDY IN nm RAT wmI RECOVERY PHASE 

APPENDIX 7 - MOTOR ACTIVITY (MOVEMENTS /5 MINUTES) 

-. 12 

IilaCUJ'f a D08II r.n:u.. 100 nil SU. J'IIII.U8 

PlUOD (JIXIII) 

....... .,. 1-' 1-10 11-11 u-ao aI-21 21-30 n-JI "-40 41-45 45-'0 


71 .0 13 t4 I' 10 IS .. I .... 72 7S 7. !IIi .1 37 20 14 71 " " 7S .. 74 ,. 731 n 74 " II 12 '" '" II 113 111 10' 121 12' " 114 "lU 711 I. ,. 102 7:1 71 7S '5 71 

16 153 IS ". 41 I 12 1 0 7S••

14 70 47 III 74 77 II 

•

411 12 " 71 It II II ., 7a "ztI :u 41 " 

., .." ••

"t 14 731 72 40 34 15 II 72 

I. II II ... 50 1 31 17 4 I. II 

'BEGULATORY/REPORT - 224 

90 DAY INHALATIO:'ll TOXICfY STUDY 1N THE RAT WITH lECOYERY PHASE 

APPENDIX 7 - MOTOR AC11V1TV ~OVEMENTS I 5 ..NUTES) 

I11III:, 12 

4iIIOU1' • 3 DOIII: .......... 30..... 80, I'IIIIUoII8 

iIIIllOD (IIIU) 

UIIIU. 110. 1-5 '-10 11-15 16·a 21-1a :I'-H 31-3S 31-40 41-45 "-SO 

11 

n 

n

••

IS 

II 

17

••It'II 

.1 

61 

17 

!II 

70 

511 

to 

.1 

57 

72 

••

75 

11 

14 

I' 

" 13 

" 16 

75 

71 

70 

II 

73 

II 

n 

71 

II 

".. 

61 

10 

71 

II" .,. 

.2.2 

70 

n 

5. 

37.1 

as

.. 

51 

77

.. 

" 1 

23 

50 

U 

If

••

U 

51 

71 

76 

4. 

11

... 

13 

10 

76 

61 

11 

61 

7. 

:10 

" S, 

73 

42

,. 

73 

7 

77 

74 

2S 

" 51 

.0 

5. 

.2 

83

.. 

51 

67 

1 

72

,. 

13 

14", 6a 

." 

.1 

U 

16 

REGULt\TORYAtEPOR1 - 225 
90 DAY INHAlATION TOXKTY STUDY IN THE RAT wrrH RECOVERY PHASE 

APPENDIX 7· MOTOR ACTIVITY (MOVEMENTS /15 MINUTES) . 

...... 12 

-. .. D08II UVIDo. 1000.1'11 BU• ....aLlIS

..IOD (1IDl8) 

.IoIIDIlIL 110. 1-5 6-10 11-11 lI-n U-U 21-30 31·3& 3.-<10 41-"1 41-110 

91 100 n 16 31 '3 21 1 20 10 97 


92 17 70 611 119 Sol <It 59 55 .. 0 72 


93 17 11 71 71 .. 62 611 ". 70
 '4 77 6' " 15 17 76 76 n 70 n ,. 15 62 60 6. n '2 10 70 II

I. ,. '7 •• 19 72 .2 " II 71 

.7" 711 13 S .. " 22 .3 60 116 "to 10 ... ,. 'I 611 73 62 117 U 117 'I 61 ,. '2 •• ,. 67 11 113 100 10<1 10.. 100 " " 76 71 SI 2 <I 6 <It 13 13 n 

~GULATORY~RT - 226 
90 DAY 1NHALAIlON TOXICTY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 8 • INDIVIDUAL HAEMATOLOGY 


Key: 


The following abbreviations may appear in this Appendix. 


M 

F 

NO 

HB 

RBC 

Her 

MCV 

MCH 

MCHC 

PLT 

wac 

NEUT 

LYMP 

MONO 

EOSI 

BASO 

LUC 

PT 

APPTS 

RETICS 

sec 

male 

female 

number 

haemoglobin 

red blood cell COlBlt 

haematocrit (packed cell volume) 

mean cell volume 

mean cell haemoglobin 

mean cell haemoglobin concentration 

platelet count 

white blood cell rount 

neatrophil count 

lymphocyte count 

monocyte count 

eosinophil count 

. basophil rount . 

large unclassified cells 

prothrombin time 

activated partial thromboplastin time 

reticulocytes count 

seconds 

Blood ceO morphology comments 

ANIS 

MICR 

MACR 

HYPO 

HYPR 

VAR 

LEFT 

BLAS 

ATYP 

1 

2 

3 

aniscytosis 

microcytosis 

maaocytosis 

hypochromasis 

hyperchromasis 

varichromasis 

increased left shift 

blastocytes 

atypical 

slight 

moderate 

marked 

Only positive findings are presented. 

If ~ere are any text comments describing blood cell 

morphology they will appear at the end of this Appendi"(. 

'REGULATORY/REPORT - 227 

90 DAY INHALATION TOXICfY STUDY IN TJIB RAT WITH REroVEI.Y PHASE 

APPENDIX 8 -INDIVIDUAL HAEMATOLOGY 

QIlOVl>, 1 ooa Lll'fJlLI 0 ppa 

lID' IGLI 

.. IIIIC -.v 1M2 -= ~ .... ..DIU. lID ... ....... 110 Sl/U U·U/I J!1 PII· 
 Sl/U 111 dO·'/l


1 II 141 16.0 7.'2 53 •• 36.' 0.'06 IOU
 I ..' 


2 II it 11.1 I.U 52.4 17.' 34.0 0.'4' 127 


:I II 14 14.9 I.U 110.' 17.' ".0 0.&:1. nl 


4 II 14 11.0 1.'3 51.' 1•• 1 '4.' O.UI 102.1 


• II 14 1&.1 7." 53.0 1'.2 ".3 ..,.. .,0 

, K it U., 1.70 50.7 17.1 n.1 0.'&1 103:' 


7 U 1&.& 1.31 ".5 1'1'.' 3'.3 0.'" ...
 • 

I I( U U.I •• 15 112.' 11.1 34.7 ••12. 71& 

, • U 14.2 '.31 50.5 17.1 33•• •.no '50 


10 II 14 U.7 '.1Il 50.7 11.a ,13.' 0.432 10" 


IREGULATORY/REPORT • 228 

90 DAY INHAI..ATION TOXICI'Y STUDY IN THB RAT WITH RECOVERY PHASE 


APPENDIX 8· INDMDUAL HAEMATOLOGY 

IiIioII:P • 1 

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t II 101 '.:11 1,17 3.01 O.tO 0.11 0.01 0.0' 

10 II U 6.sa 1.101 '.15 0.10 0.17 0.01 0.06 

REGULATORY/REPORT - 229 

90 DAY INHALATIONTOXlCfY STUDY IN mERAT WfI'H RECOVERY PHASE 

APPENDIX 8 -INDIVIDUAL HAEMATOLOGY 

iIIIOG'I' • 1 

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REGUlATORY/REPORT - 230 
90 DAY INHALATIONTOXICTY STUDYIN THERAT WJI1I RECOVERY PHASE 

APPENDIX 8 .. INDIVIDUAL HAEMATOLOGY 

GIIOUJI. 1 D08S LII9III.. 0 .... SIII:. I'IIIIUdI 

lDI DC )ICY IICII -=ac IIIC'I' .L~ 

lmI.... .. 1IIIIU:

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112 r 14 13.' 7.31 54.2 1I.t !C., 0.3111 tn

, 153 16 U.t 7." 53.6 U.t 35.3 0.6al 170 

Ie r Ie It.6 7.'2 113.0 l'.t 311.6 0.60t 'III 

65 J' 14 U.t 7.17 113 •• 20.1 37.6 0.3'2 '0' 

.6 J' 141 U.5 113.3 It.t 36.3 0.311 7.3 7 ••' 

, 141 16.4 7.56 U.3 It.l 1I7 .2 0.3" .,1

6. " , It 13.7 7.11 11.2 11.2 35.6 0.301 .4. 

6t r 141 U.t 7.17 n.2 it. I lIS.t 0.t21 Ion 

, 70 It 16.3 &3.2 It.! lI6.0 0.3ta t71 7 ••' 

~GULATORY~PORT - 231 
90 DAY INHALATION TOXICIYSTUDYIN THE RAT WITH REOJVERYPHASE 


APPENDIX 8 .. INDIVIDUAL HAEMATOLOGV 

GIIOOP, 1 

II&'ItI nIIoUiIi 

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110 

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DC 

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•• r 14 5.lIt l.z:r. ••50 •.U D.O• 0.'1 0.0' 

IS 'I 14 ...15 •• 67 1.2' 0.'7 0.05 0.02 0••' 

16 'I 14 3.31 0 •• 2.:17 •••• D.l. 0.01 •• 04 

17 ., 14 2 ••3 •• 71 2.'7 0.01 0.07 0.01 0••• 

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REGUlATORY/REPORT - 232 
90 DAY INHAlATION TOXICfY STUDY IN TIm RAT WlTIi RECOVERY PHASE 

APPENDIX 8 -INDIVIDUAL HAEMATOLOGY 

CIiCIIIl'. J SID'.. PIilIDLJI IlOIIJI LJIVR.. 0 ftIII 

AllDII.L 

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lID: -­

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RBGULATORY/REPORT • 233 

90 DAY INHALATION rOXlCfY STUDY IN THE RAT wrrn RECOVERY PHASE 

IIUIIaL

...... 
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12 

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APPENDIX 8 -INDIVIDUAL HAEMATOLOGY 


IIICY at:B ..C IIC1' 1'10' 

~1 P9. fl/4l. III &10·'/1 

51.'. 17.s » .• 0.41' 'I' 

SO.I n.4 34.S 0.411 '75 

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52.1 11.7 311.3 .....11 In 

52.0 17.5 33•• 0••7 11.&0 

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S2.1 U .• 33.' 0."" ,n 

SO.o 1'7.' !III•• 0 ....' lU2 

'REGULATORY/REPORT - 234 

90 DAY INHAlATION TOXICIY STUDY IN THE RAT wrrn RECOVERY PHASE 

APPENDIX 8 -INDIVIDUAL HAEMATOLOGY 

MDIAL

-

aou.. 2 lID:I IIlIIdI 

lID: IIIDII: 

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on LDIP .., _I IWIO LUC 

110 alO-'/l zlO-'/l z10-'11 zIO-'/l z10-'11 alO-'/l z10-'/l 

11 II 16 5.71 1.'0 6.02 0.16 0.10 0.03 0.01 

12 II 16 5.06 1.0e 3 •.n 0.0' 0.11 0.03 0.0' 

U II 16 5.20 1.36 3." 0.13 0.1' 0.02 0.11 

16 II 16 5." 1.51 3." o.oe 0.26 0.01 o.oe 

15 II 16 5.67 1.21 6.16 o.oe 0.14 0.03 0.06 

16 II 16 6.U 0.'5 2." 0.07 0.21 0.01 0.03 

17 II 16 6.It 1.06 31.17 0.07 0.11 0.01 0.01 

1. .. 16 6.67 1.26 3.06 0.11 0.10 0.01 0.01 

It .. 14 7.n 1." 5.11 0.15 0.16 0.02 0.07 

20 .. 16 S.ts 1." 3.77 0.11 0.16 0.01 0.06 

~GULAjORY~ORT - n5 
-- - --

90 DAY INHALATION TOXlCI'Y STUDY IN THE. RAT WITH RECOVERY PHASE 

APPENDIX 8 - ..DMDUAL HAEMATOLOGV 

GIOVI'. 2 II08S 10..... 110 

... 

lisa sa..... 

PI un DlICB 

.uDAL sa aD • 

11 10& 11•• 2 •• • at.' 

12 1« 111•• 2'.1Ii I •• • 

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11 11 IMI IMI 2.1 • 111 It 22 .• 2.1 • 11." 

11 1.. 14.7 24.11 • 1.' 17 14 22.' 2.1 • 15.' 

1. It 111.3 2.... 2.2 • 

1. 11 15 •• 2 ... ' 2.1 • 

20 14 11.0 21.11 I.' • 

'REGUlATORY/REPORT - 236 
90 DAY INHALATION TOXICI'Y STUDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 8 .. INDIVIDUAL HAEMATOLOGY 

aoaP. 2 IXS1I LBY.U., 100 

.. lis- BIll[I t'IIIIIIr.JI 

DC JICY lICK IICIIC IIC'I' Jr.!

U:na.r. BIll[ .... JIVIIIIIIIl 110 ./40. 10"12/1 t'1 .,40. 1/1 dG"./l 

., "" 71 14 14.3 7.'1 83.4 11.1 31.3 0.401 1&53 

., 72 14 1$.5 1.10 113.1 11.1 31.1 0.433 "2 

., 73 14 13.' 7.32 51.4 11.' 3'.2 0."7 Uu ., 74 U 14.1 7.2' 53.4 11.4 3'.3 O.lIl .00 

., 7S 14 15.41 7." 11.1 11•• 3'.5 0.412 612 

., 76 14 U.S T.U 52.4 241.2 H.' 0.317 ,.4 

., ,,. 77 14.. 14.4 7.38 12.1 11.5 37.4 0.,.4 

71 ., 14 13.' T.U 52.1 U., 33.7 0.413 '" n r 14 14.7 52.' 11.3 ".7 •• 4411 1142 '.'2 

141 r 14 14.$ ',341 52.1 11.' :17.' 41.3" 'OS 

~GULArORY~ORT - '137 
90 DAY INHALATION TOXICTY STUDY IN THE RAT WITH .lECOVERY P.HASE 

APPENDIX 8 • INDMDUAL HAEMATOLOGY 

GIIOUI'I Z 

81m. I'IIIIItoLB 

DCJIim LK1'ILI . 100 lJIIII 

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n p 14 ....1 1.13 3.410 0.01 0.11 0.03 0.011 

74 p 14 5." 1.73 3.73 0.11 0.10 0.03 0.011 

75 p 1.. 3.73 0.'" I." 0.0. 0.04 0.04 0.011 

7' P 1<1 5.01 0 ••' 3 •• 0.0' 0.1<& 4).0" 0.0' 

77 r a 3.97 1.U z .... 0.0. 0.01 1).02 0.011 

7B r 14 11.30 1.10 s.... 0.131 0.11 C.O" 0.07 

7' r 1... 3.12 1.07 a.sa 0.1:1 0.07 t.02 0.04 

10 p 1.. ...U 0 ••2 3.10 0.0' 0.~ 1).0" 0.011 

~GUL~TORY~R1 - 238 
90 DAYINHALATION TOXlCfY STUDY IN THE RAT WlTIf RECOVERY PHASE 

APPENDIX 8 .. INDIVIDUAL HAEMATOLOGY 

GIIGIIJ'. 2

sa:r• .....,.. DOSI: LIWJIL. 100 PPI 

Maar.

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... 

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75 r 14 16.' 25.' 1.' 

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'71 r U 15.' 23.0 2 •• 

1t , 14 16.11 23.' 3.1 

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REGULATORY/RE?ORT - 23~ 
90 DAY INHALATION TOXICIY SIUDY IN 1lIE RAT WTIH RECOVERY PHASE 

APPENDIX 8 -INDIVIDUAL HAEMATOLOGY 

UDAL

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fREGULATORY/REPORT • 240 
90 DAY INHALATION TOXIcrY S11JDY IN TIm RAT WJfH RECOVER.Y PHASE 

APPENOIX 8 • INDIVIDUAL HAEMATOLOGY 

UOUl'. 3 

lUI DLI 

DOlI! r.wv.r.I 3.0 .... ..DIAL ...... sa: 

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22 .. 14 5.21 l.12 1.01 0.07 0.17 0.'1 0.0" 

a:J .. 1<1 6.1' l.14 ".lIl 0.16 0.11 '.03 0.13 

2 .. .. 14 S.55 l.2.2 ... OS 0.07 O.u. 0.03 0." 

25 .. 14 5.U ~.12 ".n 0.01 0.15 0.03 0.01 

26 .. 14 1.25 1.70 S.U '.11 O.lS 0.011 0.13 

27 

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30 .. 14 5.1<1 t.I" 3." 0.11 0.01 0.01 0.06 

~GULATORY~ORT • 241 
90 DAY INHALATION TOXICTY STUDY IN TIlE RAT wrm RECOVERY PHASE 

APPENDIX 8 .. INDIVIDUAL HA!MATOLOGY 

&IlOUI'. 3 

DZ...... DOIIlI LII'nIL. 300 ppa 

-­ .!I An'! D'llCS .IIIDIlU.

..... BIt 110 -­ ..It t 

:n. • 16 11.6 :U.3 2.3 

22 I 14 1'.1 24.5 2.' 

33 I It 11•• U.4I 2.7 

It I It 15.2 21.7 2.0 

211 I It III.Z In.l 2.0 

26 I 16 16 •• :U., Z.' 

n • It u .• 31.! Z.O 

2! I U 111.0 U.S I.! 

2. I U 16.7 24.6 2~' 

30 I 11 1'.2 2'.2 2.0 

~ULATORY~ORT • 242 
90 DAY INHAlATION TOXICI'Y STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 8 • INDIVIDUAL HAEMATOLOGY 

GIIOUJI. 3 D08JI 1aBYSL. 500 fill ID.~ 

...ow:. ID 

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n UC IICII' IICII NC:IK IIC'I' r''I 

IIUlIIID JIG ./41 10~.u/l III PII· ./41 1/l. .1e~'/1 

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82 r U U.3 7.60 5'.4 11.1 3&.5 0.'13 as, 

IS r 140 14..5 7.40 &:1.2 1'.1 ».1 0.$9" 7'3 

II r 14 1'.' 7.13 n.1 11.' 301.2 0.121 1.1 

as r 14. 140.7 7." n.l 19.2­ ••2 0.4" 124 

II ,. 14 1'.1 7.12 12.1 II.' 36.2 0.'01 1013 

.7 r 14 14..' 7.41 !IS.' 20.0 3'.4 o.sn 174 

II r 14 14.' 7.12 55.' 11.' !I.' 0.413 '1' 

n .. 14 14..5 7.'1 54.2 19.7 3'.4 0.40G 113 

•• r 14 11.7 7.n 12..7 19.1 37.11 0.411 771 

~ULATORynuwORT . 243 
90 DAY INHAlATION TOXICI'Y STUDY IN THERAT WII'H RECOVERY PHASE 

APPENDIX 8 .. INDMDUAL HAEMATOLOGY 

GIIOUJI. :I 

JIDI .I'IIA!.Ir 

DOD ......... 300 ... ..... ""DUlL ID ...

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IS r 14 2.45 0.42 1 ••5 O.O~ '.0' 0.02 0.01 

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'RE.GUlATOltY/RBPORT • 244 
90 DAY INHALATION TOXICTY STUDY INTHB RAT WITH RECOVERY PHASE 


APPENDIX 8 .. INDIVIDUAL HAEMATOLOGY 

CIIIOUP. 3 ... I'IIIGLII D08B LI¥ID'.. 30' ,.... 

MDrAL

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13 I' 16 111.0 as.5 1.' 

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11 P 16 It... aa•• l.1 

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II I' 140 U.S 22.2 2.7 

'0 .. U 16.1 21.1 1.:1 

'REGULATORY/REPORT - 245 

90 DA,\, INHAI.All0N TOXlCfY STUDY TN THE RAT WITH RECOVERY PHASE 

UDIU

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'.:15 

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APPENDIX 8 -INDMDUAL HAEMATOLOGY 


IICY IICII IICIIC IIC7 .L'I' 

~1 JIfI. rlliU. 1/1 alO*")' 

n.1 n.t 31." O~"l '120 

12•• n.l ~,." ••.,.4 lSI 

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fO.' 11.0 311.4 0.41' 131 

.t., ".1 16.7 0.·'" "4 

REGULATORY~ORT • 246 
90 DAY INHALATION TOXICTY STUDY IN THE RAT WITH RECOVERY PHASE 


APPENDIX 8 • INDIVIDUAL HAEMATOLOGY 

IIIIOCI'I 4 sa. IIIALII D08II 1oIVZL. 1000 lis­ _1 DC IIIIV!' Ii'llll' ...0 8UO U1'C 

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12 .. U '.37 2.31 3.'1 0.11 0.12. 0.0' 0.10 

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REGULATORY~ORT - 247 
90 DAY INHAlATION 'IOXICTY STUDY IN THE RAT WITH RECOVER"'i PHASE 

APPENDIX 8 -INDMDUAL HAEMATOLOGY 

GIIIOQI. c 8D:...... DOBI " .....". 1000 ppa 

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3' M 14 l.Ii." 19.1 2.0 

CO • It 11.6 21.lI 1.' 

IllEGULATORY/RElORT • 248 
90 DAYINHALATION TOXICTY STUDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 8 -INDIVIDUAL HAEMATOLOGY 

GIIOOP. 4 IJCIiIII LIIftIo. 1800 .... lID. I'IIIIUoI 

.. -­

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14 r 14 14••- 7.tO 53.2 1••3 U.3 O.4U 11117 

.S r 14 II•• 7.93 5:1.3 II•• .K.l 0.415 11M 

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91 r 14 14.1 .,.$1 52.0 11.1 31.3 0.'01 

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100 r 14 15.0 1.15 1lI.1 11.7 - 11.1 0.,1t ,.2 

IREGULATORYIREPORT - 249 

90 DAYINHALA110NTOXICTY STUDY [N THE RAT wrm RECOVERY PHASB 

APPENDIX 8 -INDIVIDUALHAEMATOLOGY 

, CIIOU1I'. ooa LII'¥lIr.. 1000 ppa ax......... 


... .., Dc: L1'III' 11»1 IIAIIO IiIJC UlIIDoL I1IIt IIIIIB ..... 110 dOft"1 :IILOft'/1 :IIU-,.I1 alO-'1I :111.-1/1 al.-"I lIl.-"l 

111 r 14 2.51 ..,. 1.11 0.0' •• )1 0.01 0 ••' 

, IJ 14 2.12 '.13 1." 0.05 0.07 •• )1 0.03 

til r 14 '.'7 1.05 l.U 0 ••' 0.01 0.)2 0.0' 

... r u S.Ol 1.21 3.41 0.1:1 0.10 0 0.0' ••' 

'5 r U l.'O '.7' 2.115 O.OS ••0' ..... ..0' 

t, F 14 ".27 1.12 2.17 •.11 ••0' O.J! •••5 

17 r 14 ....1 1.2. 3.35 •. 10 0.11 0.t3 0 ••3 

•• I 1 .. ,.,. 1••7 3.24 ••01 0.11 0.J3 0.05 

It I 14 3 ... '.15 2.71 0 ••7 0.11 •• J! 0.04 

1•• I 14 4.20 ).71 :11.15 0.11 0.09 0.02 0 .... 

IREGUlATORY/REPORT - 250 
90 DAY INHALATiONTOXICfY STUDY IN TIm RAT WITH RECOVERY PHASE 

APPENDIX 8 -INDMDUAL HAEMATOLOGY 

GIlOVI'. of. 

sa. J'IIIIGIoa 

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~GULATORY~ORT - 251 
•• • 

90 DAY INHALATION TOXICfY STUDY IN 11IE RAT Wl1lI RECOVERY PHASE 

cmo1IIP, I au, IDIoJ: 

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APPENDIX 8· INDMDUAL HAEMATOLOGY 


IICY IICII IICIIC .C'I' JILl! 

f1 PI­ ./41. 1/1 .10-,,1 

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12.1 11.1 SI.1 0.617 7n 

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IREGULATORY/REPORT • 252 

90 DAY INHAlATION TOXICTY STUDY IN THE RAT WfnI RECOVERY PHASE 

APPENDIX 8 -INDIVIDUAL HAEMATOLOGY 

anw.

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110 II 11 I." 1.22 4.40 0.11 0.1' o.oa 1.01 

~ULATORY~PORT • 253 
90 DAY INHAlATION TOXICI'Y STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 8 - INDMDUAL HAEMATOlOGY 

CIIIOCI7 , 5 DOIIB LIYU.. 0 W- IlD. II'ALB 

AJ"J"I' UlrIca 

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REOULATORYfflEPORT • 254 
90 DAY INHALo\TION TOXlCfY srUOY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 8 • INDIVIDUAL HAEMATOLOGY 

~. 5 Sa:. I'IIIDI.S 

DOS:I t.ftI:L. 0 P.­

"DIAl'. au: ... BB DC IIe'I lICII EIIIC IlC'r 1'10'1' 

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101 I' I' U.S 7." 1111." 1••2 :12•• 0."42 1117 

102 I' 18 14.1 7.76 14.3 1••2 33.11 0.":1.2 11m, 

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106 I' 1. 14.6 ••1' 1IS.4 17.' 32." 0.4011 '17 

107 I' 1_ 1t.1 7.73 14.3 11.2 33.11 0 ••20 1002 

10. I' 11 1t.6 7.01 M.7 11.3 33.' 0.'33 .17 

10. I' 1. 11•• 7.711 U., 17.' 32.11 0 ••17 loa. 

110 r 11 141.7 ••31 56.11 17.1 SI.t 0 ••S6 "3 

REGUlATORY/REPORT - 255 
90 DAY INHALATION TOXlcrY STUDY IN THE RAT WITH REOOVERYPHASE 

APPENDIX 8 -INDIVIDUAL HAEMATOLOGY 

alUJ'. 5 DOH t.sn:L. 0 JIiIII.
 sa:. naGU.1 


...., ftC IIlI1I'I' IoJlll' IIOII D80 love .llDIU. sa: ... 

IIOIIID' 110 :11:1'-'/1 XlD""/~ al0*'/l al0"tll alO-'/l .10"'/1 XlD*'/1 

101 1. 2.U 0.52 1 • .,. 0.0. 0.01 0.01 e.o:I • 

loa • 11 2.n 0.5~ a.lI 0.11 0.01 0.'3 G.OI

103 P II 3.U 0.13 a.50 '.Of '.10 0.01 o ••a 

10. • II 3.31 0.53 2.13 0.05 0.11 0.02 0.'4

lt1 II 3.2' 0.'0 2.31 0.0:1 0.10 0.0. 0.0" • O.OT 


107 1. •• 415 1.11 3.04 0." 0.14 0 ••• 0.07 


10' .. 1. ..ot 0.'2 3.'1 0.0' 0.'3 0.01 

• 

loa 11 3.4'7 ..., a.57 0.01 0.01 0.01 0.05 • 

101 10 3.a3 ••il 2.30 0.0' 0.11 0.03 0.01 • 

110 P 1. 4.'. ..,. 3.51 0." 0.0' 0.04 0."

REGUIATORY/RBPORT - 256 

9QDAY INHAlATION TOXlCIY STUDY IN11iE RAT WITH RECOVERY PHASE!. 

APPENDIX 8 -INDIVIDUAL HAEMATOLOGY 

GJIOUl'. , IIIZ......... IlOIB LIYIIL. 0 lisJIWI&L

...... ID ... 

110 

JI'I'

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103 I' 11 16.2 :U., 2.0 

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105 I' 11 17.6 :n.1 1.7 

106 r 11 15.1 :12.1 2.3 

107 r 11 16.6 2'.2 1.7 

181 P 11 1'.' 2I.1i 1.1 

1•• I' 11 1'.1 :at., 2.1 

110 r 11 11.7 23.1 1.6 

ffiEGULAjORY~RT - 257 
90 DAY INHALATION TOXICI'Y STUDY IN 1HE RATWrrH RECOVER.Y PHASE 

APPENDIX 8 .. INDMDUAL HAEMATOLOGV 

aout. , 1I08S ...,...,. 1100 

.. Ps­ au, IIILI IIBe IIC'I IICII 1ICBC JIC'I' PL'I ..uw. AS ... ..... 110 lI/eU 10-12/1. 11 pt. ./41 1/1 :d'-'ll. 

S! II 11 14•• .... M .• 1".4 :I..... ..," .3. 

sa II 1. 14.' '.21 51.0 17.4 :14.2 0.41' '"'' 113 1. 14.' '.1. U., :\4..1 ••4$'7 Ule 4••' 


54 II 1. 14.0 1.17 $2.:1 n.2 u .• 0.U7 


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III • 1. U •• '.30 1.1.1 U •• 31.4 0.4:12 til 

lit 11 1<1.1 ..... 51 •• u.? aa.3 0.41' ... • 

f. II JI 106 •• .... 110.7 16•• 32.' 0.411 1061 

'REGULATORY/REPORT - 2.'58 

90 DAY INHAlATION TOXICIY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 8 • INDIVIDUAL HAEMATOLOGY 

GlOVP. 6 J:IOSt LnJIL. 1000 W­ SUI IIUJI 


nc IIIPJ! r.DIP l1OlIO ..I IWIO LVC 

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110 xlO-"l xlO-'/l :d0-'/1 :dO-'ll xlo-"1 :dO-til :dO·,/I 

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1.:1. .. 11 C••O 0." 3.31 0.37 0.16 O.Ol 0.03 

1.40C 3.60 0.'1 0.30 ••01 0.71 

54 II 11 1.11 1.21 3.22 o.n •• 17 0.01 0 ••• 

'3 .. 11 '.15 

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16 11 3.16 0.'0 2.01 O.tll 0.1:1 0.01 0.02 • 117 .. 11 5.11 1.n 3.311 O.tl 0.111 ••OD 0.05 

II 8 11 •. n 1.33 3.01 o.a, O.U '.01 0.03 

!It 8 U •• 71 1.31 2." I.Dt 0.17 0.01 0." 

60 iii U ••00 1.06 2 ••3 o.a. 0.140 0.01 0.03 

~GULATORY~RT - 259 
90 DAY INHAlATION TOXICIY STUDY IN THE RAT wrm RECOVERY PHASE 

APPENDIX 8 - INDIVIDUAL HAEMATOLOGY 

GIOUP... 

lID. IIlILJI DOIIII r..B'flI:L• 1000 ..... 

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53 II II 16.1 2a... i.:I 

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56 11 18 16.1 23.7 2.1 

57 .. II 16.1 26.5 2.1 

II II 11 16.1 23." 2." 

" II II 11.1 i6.1 1 •• 

60 II 18 111.' 25.' 2.1 

'REGULATORY/REPORT - 260 
90 DAY INHALATIONTOXICTY STUDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 8 -INDIVIDUAL HAEMATOLOGY 

GIIOOPa I IIOR LIIYIIL. lOGO 

.. PPI au, I!'lDIiILK IIJIC MeV tICIlC IICI' FLY 

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111 r II IS.' '.12 53.1 U.2 34.3 0.414 ,27 

112 r 18 13.' 7." 111.1 18.2 32•• '.42t. 1011 

113 r II 14.' '.25 54.2 17.7 32.7 0.4407 US 

114 r II 15.3 1.01 11.3 11.1 34.5 D."" '17 

115 l' 18 13.' i.U 55.2 11.7 33.' 0.410 721 

116 :r 11 13.1 7.31 54.' 18.• 33.1 0.401 .,. 117 l' 1. 13.' '.Z3 5111.1 18.• 33.' 0.402 11111 

11. '1 11 IS.1 i ••5 16.2 II.' U.I 0."04 UZI 

11. 7 II U.l 1.00 14.1 1'1.1 32.' O.4U 1031 

120 r 18 14.2 '.11 54.1 11.0 33.2 0.427 101' 

REGULATORyauwORT - 261 
90 DAY lNHALATION fOXIClY STUDY IN THE RAT wrm RECOVERY PHASE 

APPENDIX 8 • INDIVIDUAL HAEMATOLOGY 

GlOIW. I 

SUr ......u: 1lOIII LJIY1Pi,. 1000 PIIII 

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113 P 11 3.U o.n 2.7a 0.11 0.11 O.OL 0.0. 

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111 r 11 2.74 0.'0 a.lI 0.~3 0.07 O.OJ 0.01 

111 r 1. 3.'1 0.71 2.'1 O.lO 0.07 0.01 0.04 

117 P 1. 3.14 0.13 :Z.U 0." 0.11 '.Ol 0.01 

11. P 11 4.73 1.11 a." 0.12 0.07 0.01 0.04 

U, p 11 2.32 0.5' 1.57 ..., .... 0.'. '.03 

120 P 11 3.57 0." 2.11 0.01 0.07 0." 0." 

'ROOUlATORYIREPORT 262 
90 DAY INHAlATION TOXlCI'Y STUDY IN THE RAT wrrn RECOVERY PHASE 

APPENDIX 8 -INDMDUAL HAEMATOLOGY 

GII(Ift. , 

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111 I' 11 16•• 23.7 2.1 

12. I' 11 17.1 31•• 2.2 

REGULATORY~ORT • 263 
90 DAY INHALATION TOXICfY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 8 -INDIVIDUAL HAEMATOLOGY 

1ItCMII'. 1 00II1 LIIYIn'o. 0 ppe 

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'REOULATORY/REPORT - 264 
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APPENDIX 8 ·INDMDUAL HAEMATOLOGV 

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REGULATORY~ORT . 267 
90 DAY INHALATION TOXICIY STUDY IN1lIE RAT wrm RECOVERY PHASE 

APPENDIX 8 .. INDIVIDUAL HAEMATOLOGY 

GIOUJ'. 2 DOQ LrIIIIL. 100 PIlI 

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~GULATORY~RT - 268 
9O.DAY INHAlATION TOXICIY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 8 • INDIVIDUAL HAEMATOLOGY 

GIIOUl'. 3 OOSJI IonJIL. 300 .... 81:1:. lULl 

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REGULATORY~ORT - 269 
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90 DAY INHAlATION TOXICI'Y STUDY IN TIlE RAT WITH RECOVERY PHASB 

APPENDIX 8 - INDIVIDUAL HAEMATOLOGY 


Summary Of Data Not Entered Onto ARTEMIS From Manual VerlftcaUon of Blood Films 


No Fla 

a ."

. Neutro phil 

Lymphocyte 

Monocyte Eoainophil 

B.sophil 

Other 

RS 

7 C 

Polychromasl Anisocytosl 

a + s 

Microcytosi + 

+ S + 

RS 

17 C "olychromasi Anisocytosi 

a + s 

Microcytosl + 

+ s .. 36 IG 34 62 1 2 0 Band NeutroPlil 1 

40 IG RSC 31 64 2 2 0 Band Neutr()Ji111 1 

Polychromasl Anlsocytosl 

~ + s 

h'araet cells present 

Microcytosi + 

+ s + 

61 IG 

73 IG 

77 IG 

35 61 2 2 0 

20 77 1 2 0 

23 73 2 2 0 

REGULATORY/RBPORT - 277 

90 DAY INHAI..A.TIONTOXICl'Y STUDY IN THE RAT WITH REroVERY PHASE 

APPENDIX 9 - WDIVIDUAL BLOOD CLINICAL CHEMISTRY 

Key: 

The following abbreviations may appear in this Appendix. 

NO · number G~GT - gamma glutamyl transferase 

M • male POTIlUM - potassium 

F • female C/RIDE - cbloride 

CRININE - creatinine PHOS/uS - phosphorus 

T.PROT - total protein UREAN - urea nitrogen 

CH/STRL - cholesterol TRIGS - triglycerides 

ALP - alkaline phosphatase T.BllJ - bilirubin 

ALT - alanine aminotransferase NGRATIO - a1bumin)globulin ratio 

AST - aspartate aminotransferase PCoA • palmitoyl coenzyme A 

CK .. creatine kinase 

If there are any text comments they will appear at the end of this Appendix. 

'REGULAroRY/REPORT . - 218 
•• 

90 DAY INHALATION rOXICIY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 9 - INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

IHOVP. 1 D08I LftKL. 0 ~ 

SD. IIAloI: 

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 _;1./1

1 .. 101 171 '12 2.7S 2.11 165 n
 " 2 .. 1<1 U9 103 I •• 2.02 It 6" 


3 .. U 210 U2 129 2.1'7 2.21 17 
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6 It 190 ,. to 2.'1 1.11 UI 31 • 

5 .. It 17 102 2." 2.27 II 3t 11'

• .. U 27' 77 90 2.60 1." 122 36 


7 .. U It2 112 137 2.11 2.15 15' .. 
 , .. 1<1 151 '0 " :I.7Ii 1.11 115 "
 • .. U 171 17 III 2.11 2.10 '.1 U 


10 II 1. 133 111 71 2." 2." 12 39 


~GULA~RY~ORT - 279 
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90 DAY INHAlATION TOXlC1Y STUDY IN 1HE RAT WITIl RECOVERY PHASE 

MI:III.I. 

tr.IIIIBIIJl 

1 

2 

3 

" 

5 

6 

7 

I 

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a:u:..... 

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31.1 

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32.2 

30.1 

n.7 

30.1 

APPENDIX 9 - INDIVIDUAL BLOOD CLINICAL CHEMISTRY 


0 .... I'LUIIII. 

'!'.'1.0'1' 

.LA8IIG 

C-R 

..,.,... !'.BILI 

A/G 

JlAftO 

IIIAIOD _. ......­ LI.IDS 

fill IVII _111 -.1/1 _/1Ro 

"".1 7.01 3.21 0.t7 3.71 111.'. 61 .• 7.U 2.U 1.12 3." 11'.17 

63.3 6.61 3.'t O.tl 3.24 "'.72 

n.3 1.27 3.30 1.12 3.34 11'.12 

n.' 7.&1 3.37 1.07 2." 1&3.27 

62.0 6.60 3.4<& 0.'1 •• 12 111.03 

62.' I.'" 3.52 1.01 3.51 U7.2I 

51.5 6.'3 3.'5 1.01 3 ••' u •.,. 

5t•• I.U 3.13 1.00 3.11 In.12 

!l1.t t.11 3.1. 1.06 3.21 157.71 

IREGULATORY/REPORT - 281 

90 DAY INHAlATION TOXICfY STUDY IN TIm RAT WITH RECOVERY PHASE 

APPENDIX 9 - INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

GIIOII'P. 1 0081 LII'ISL t 0 PIlI 
 SIIll. I'IIII.I.I'dI 


umw. lID DIU: ....... .ILl' I'r.lI8IIJ. 

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CB/II'I'U 

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CII/IIDIIi ...... 110 ru/1 11/1 rull -:Lll _1/1 rull _111 

61 p 	 ,. U 10lt lU 172 2.n 2.U 152 

, 62 	 14 101 II 101 2.73 2.'" U 4t 

13 	 , 14 12 .8 131 2.1' 1.8' II t1 

, -It 14 146 74 82 2.13 2.2S U to 

, 60 	 It 102 43 81 2.18 1.19 6t G 


It l1lt '1 2.73 2.22 317 ~. , 	 I". " 67 	 , 14 1O:J 13 2.72 1.72 II 42 I.' 

, II 	 14 105 81 101 2.1'7 2.0'7 11 42 

61 , It 11 U 7a 2.'1 a.:'8 u ... 
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IREGUlATORY/REPORT • 2S2 
••• •••• 

90 DAY INHALA.TION TOXICTY STIJDY IN TIlE RAT \\TfH RECOVERY PHASE 

APPENDIX 9 - INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

GIIOVI'. 1 DOS.I r.n:a.. • Pwe SU........I 


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61 .. It 11.2 103 :S.51 142 I.'. o.n '.73 

u .. 14 '.3 103 4," In l.n 0.72 ••t3 

63 .. 14 '.3 102 4.1S6 1U 2.12 0.511 '.lI4 

6. F 14 11•• 101 1t3 2.51 0.63 '.2' '.!IIS 

U l' It 10•• 101 3,'7 In 2.4' 0 .... '.50 


66 l' 14 103 142 1.34 1.40 t,71 


67 .. 14 '.7 lOll 3 • .,,, 131 1.40 0 ••• •• 03 


II r 14 11.lI 102 '.20 1t2 1.112 0.'" '.13 


" .. 14 6,1 105 ••3:& 143 1.4& 0.14 1.00 


70 .. 14 .,.. 103 4.03 141 2.1& 0.47 8.'2 

fREGULATORY/REPORT - 283 
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90 DAY INHAlATION TOXICTY STIIDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 9 • INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

CDOUP. 2 DOSI lorna:.. 100 ppa 
 l1l:I:. IIILII 


PLAIIIfA PLUU. KUllA .r.aaa PLUIIII. JILUD n.aga 

UDIAL l1l:I: BlOt ar.. .l1li' AIft c:u.-:~ <:11/8... CIt CIl/Da ..... 110 IV/I rtl/l n/l _1/1 _111 nil 
 ~/l

11 K 14 193 77 2.'. 2.o, 13 n
 " 12 )( 14 In 74 2.15 1.72 3t " " 13 K 14 195 1:1. Ul 2.'1'11 1.91 1I11 lIi 


16 14 170 102 135 2.451 1.13 111. Il
 )( 

11:1 )( 14 180 70 .0 2.1' 1.'5 '1:1. 36 


16 K 14 24' 7' 113 2.6' 1.55 271 3. 


17 I[ 14 207 '2 102 2.71 2.17 173 U 


11 I[ 14 1'0 112 lit 2.70 2.11 1M 42 


l' I[ 14 231 110 1.23 2." 2.54 1111 3' 


20 14 15' II I. :I.n 2.at 110 n
 I[ 

REGULATDRY~ORT • 285 
- -

90 DAY INHALATIONTOXICTY Sl'UDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 9 ·~DIVIDUAL BLOOD CUNICAL CHEMISTRY 

8IIOI1.P. ::I J)OSJr &nIIt.. 1~ ppa ..... au 

'It.IISIlQ. 'IloQlQ. ~ 1'LIiIIIa 'LN!Ia .LU18 :Jlio.UIa ..nar. .... cr.vasa e/KJDI PCW/:QI lICJO~ 1'lI0II/''18 IlUCIII 

Il1O _.LIt _1.(1 -111 _1/1. _1/1 _1/1 _1/1 

-- • ••• 11 11 101 ..1. 142 l.n 1.U '.03 

12 .. 11 ..s 101 ".41 143 1.3. 1..U 1.M 

U .. U '.1 1.111 1 ••' 141 2.32 1.0f 7.'1

It It 11 .,. llU ..11 142 1.'0 0." T.n 


u .. 1<1 ••• lOJ 5.25 lU 2,•• 1.lIf '.n 


16 .. U '.1 1111 4.16 142 1.10 •.n 1." 


17 III 11 ,.. len ••.17 1.' 2.20 1.U
 ..,. 

1. • If 10.0 10' !II." 140 2.12 0.'7 ,.,. 


11 14 lOt !I..D 1,4.1 ·2.16 1.31
 • iii.' 1." 2. III 14 7•• 101 C... 1Cl 1." o.n 5." 

RBGULATORY/REPORT • 286 

90 DAY INHALJI\.TION TOXICfY STUDY IN THE RAT WITH RECOVERY PHASE 

APF'ENDIX 9 - INDIVIDUAL BLOOD CUNICAL CHEMISfRY 

GIIOU,. 2 DOSB L'8YIIL. 100 
 lis­ ~I IIALB 


l'LUII,l .~ rr.A8IA. Pa:.t.SIG. ,,/e BIoOOD JlIIDIIIn- UIJIU. so: IIIID ALB1J'IIDII ".PRO!' e-ft I.ULI ..no UJlJD& ...- BO ,,/1 ,,/1 IV/I _lfl _1/1 ..... ­ _/Dr. 

• 11 14 32•• ,... 10.13 3.43 1.02 :lI.n 150.01 

12 141 31.5 61.1 5.10 3.13 1.06 3.53 121.16 • 

13 It 30.' 61.1 •• 11 3.10 1.01 3.51 135.64 • 14 • 14 3••2 55.7 '.1' 2.13 1.1' S.'l 127.44. 

15 14 n.i '0.0 7.3' 3.U 1.12 3.411 142.11 • 

l' )I 141 31•• 111.7 '.33 2 •• 1 ••1 a." 115.21 

11 14 31.1 61.5 7.34 3.51 0." ,.O! U2.n • 

11 14 a,.' 5',3 6.IS 3 •• 1.02 3.51 135.21 • 

l' 14 31." 62 •• 5.11 3 •• 1.03 31.67 174.21 • 

20 II 14 31.6 0.'6 a.6! 140.17 '4.' ',7' a." 

REGULATORY/REPORT - 287 
90 DAY INHALATION TOXICTY STUDY IN TI;JE RAT WITH RECOVERY PHASE 


APPENDIX 9 - INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

raoa:I'. :I DOl. Lavu.. 100 II... au• ..-... 

.r.UII& .L&8IIlI. ......... .~ .:r.uu. ILIIIIA tr.Ull& 


.III1JII.l. au .... ALI' A8'I' ClLCIUII Ql/ftIIL CJI Clt/.DIII

IIUII8D I.e) llJ/1 ..." rul1 roll _1/1 ~/1 nIl _1/1 

71 p 11 100 63 71 2.75 2.11 n 17 


72 P U 12. UI 131 2.7. 1." U 31 


7' P U II I' 77 2.7' 1.,1 57 U 


n p 1. '2 2.n 1.73 77 U 


,. P 1. " .D " 61 2.75 2.0' a4 


., 

" " 76 14 141 N IS 2." 1.72 104 3' 


77 P U '7 II IS 2.12 1.'3 111 .t 


71 P U 122 .4 2.17 2.73 7a J.
 • 

7t 14 120 ID .1 2.t. 1.17 I. 50 • 

10 • 14 112 11$ 2.17 1.17 III Ii " 

'REOULATORY/REPORT - 288 

••• 

90 DAY INHALATIONTOXlCl'Y STUDY IN THE RAT WITII RECOVERY PHASE! 

APPENDIX 9 • INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

1PIlOVI'. 2 11081 LrIm.. .00 PPI

a:z. I'IIIGLI: 

I'LUIIA I'LIII8IIUI. HAIIIA .LAJaIIo. .~ l'LUIa .LUM& 

.III1:IAL lID ....: GLUcon e/lUIB I'O'l/IIJII toDJ.1III PIIOB/1I8 BIGS

-

11 r 1. 

., _1/1 _Ill ~/l _111 ~/l _111 ~/l 

- '.7 10' 5.:17 ...4 1.62 o.ea 7.1. 

12 r 14 .., 10' ••02 ..4 1.11 1.02 1."

13 r 14 14.7 101 6,07 144 1.'6 •• 71 7.13 


n r 14 13.2 101 4.33 142 1.1' '.1$ 


75 r loll '.0 105 •.M U3 1.9$ 0 •• ".30
 ' 

7 U ••2 lin 0.72 


71 l' 14 11.3 10' 3 ••• 1013 1.30 1 •• 


7' 3.'" 142 I.'" 7." 

' ••4 

7. l' U 12.11 102 3.72 143 1." 0.13 6.:11 

n l' 14 10.' 4.0' ua 1.63 0.111 " ••4 " 10 l' 14 1•. 2 .t 4.01 142 2.11 0.'0 '.112 

REGUlATORY/REPORT - 289 
90 DAY INHAlATION TOXIcrY STIJDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 9 • INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

CiIJIOIIIf • 2 D08lI 1'dYIIL. 100 ppa 


sa. raI.LII 


PLAIDG I'LIIIID. I'LUIII. I'LIoIID 1.1. IILOOD tI08J1I­ UDI&L 8111: 100II: ALIIUIIn 'l'.J'IIOt' 8-ft' ".UIoI UftO VIDl. 101,1'" 

tnIIIHJI 110 III Oil. mil _1/l. _l./l _/DL 

71 I' 1-11 n.' ' •• 1 
 '.7. 3.0J 1.03 3." 1l5r.n

72 14 aa.l ..., '.711 3." 1.01 3.se
 p 14.1••' 

73 P 14. 32:.2 51.' ••5'7 2.7S 1.21 3 ••2 1151.31 

,. f' 14. 30.' 61 •• 7.71 2.:11 1.00 2:.'7 12:1.35 

" 
 P 14 31.1 5'.1 12.12 3.11 1.11 3.U 14.7•• 


7. I' 14 n .• 5•••· 6.1' 2." 1.2. 3." 125.7& 

77 f' 14 33 •• .... 6.03 3.31 1.21 ••13 1151." 

71 f' 14. 33.S 67.1- ...., 2.6 1.00 2." III." 

79 I' 14. 32.' 63." '.23 3.&' 1.05 3.71 137.5'7 

10 • 14. 32.3 61.t I.n 3.29 1." 2 ••1 14.1."

~GULATORYnrn'ORT - 290 
--

90 DAY INHALATION rOXICIY STUDY IN THB RAT WITH RECOVERY PHASE 

APPENDIX 9 - INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

GllOUJI. 3 D08I LIMAi. 300 .". BU. IGLI: 

PLaIIIIa PLUIII. P~ .LJJIIa. .L.UD .LABA IL&IIIIa IIIDfAL ax AL. AU' AlII' c:ar.e:I1M CII/8nL a: CIIt/llUII

...- RO XVII nil IV/1 -.LIt _1/1 xvil _1/1 

21 I! U 16G ,. il 2 •• a ••• 131 4. 

2:;1 I! 1.e 1115 10 .3 2 •• 2.GO 10. n 

23 I! 1<1 204 11J., 1.2 2.7' 2.10 lOS D 

:u I! 1t 110 11 2.12 1 • .,7 IS U

" 25 I! 11 111 54 ." a.77 2.U 10. U 

26 11 112 181 1U 2.73 2.U 173 311 • 

21 I! 11 1to 17 1110 2.11 a.a7 111 A 


21 I! 1<1 18' U2 154 2." 2.32 II., 4). 


2' 11 192 15 82 2.11 2." 100 4.
 • 

30 II 1. 171 172 111 2." 3.11 U4 IS 

REGULATORY~ORT - 291 
90 DAY 1NHAlA110NTOXICTY S11IDY IN THE RAT WITH RECOVERY PHASE 

DDIUo 

lIIIHBIIII 

21 


:u 

:z:J 


24 


25 


21 


27 


.al 

:at 

30 


CIlOIIIP. J IID:....... 


au 

-., I( 14 


I( 14 


I( U 

• 14 


• 14 


I( 
 14 


• 14 


I( 14 


• 14 


• 1. 


IIOIIl r.avm. r 

~ 

GLUC8IIJ: 

_Ill 

10.1 

10.2 

7.4 

'.4 

10.' 

'.0 

'.4 

'.2 

7.' 

20.2 

APPENDIX 9 -INDIVIDUAL BLOOD CLiNCAL CHEMISTRY 

3410 .,.. ....,. fLUIII, ......... nasa. ......... I'LaSICIL


e/.IDII: ",,1m. IODlUII ..... ftl_ URA 

_111 _1/1 _111 _111 _1/1 _1/1 


10L '.14 142 1.71 1.7fo '.01 


1., 5.31 140 1.11 1.0' '.OJ 


101 '.71 UJ 2.11 1.01 1.75 


10L '.N 142 2.12 1.1I0 I." 


10& lU 1.11 7.11
 '.11 0." 

10J 4.'3 lU 1." 1.10 '.15 

10.1 4.30 lU 1.$7 1.CI '.12 


101 '.30 In 1.12 1.JI 1.52 


10) 4.55 141 1.n I.e, 1.17 


101 7.11 In l.'1 1.0. I ••a 


lREOUlATORY/REPORT • 292 

90 DAY INHALATION TOXICTY STUDY IN THE RAT WITH RECOVERY PHASE 

D_

-

21 

22 

23 

24 

25 

2' 

27 

21 

U 

3. 

~I 3 IDI III.LII 

ID liliiii. 

110 

• 14 

• 14 

• 14 

• 14 

• 14 

I 14 

• 14 

I 14 

• 14 

• 1.4 

DO&II LIIVBL. 

Pr.AIIIa 

u.a8IIl. 

ell 

32.' 

2'.1 

31.' 

30.5 

32.7 

32.3 

33.0 

32.4 

32.4 

31.' 

APPENDIX 9 - INDIVIDUAL BLOOD CUNJCAL CHEMISTRY 


SOG .... l'L.I8Im ~.nor 

.11 

I'Iio.UIIa 

III-err 

10/1 

Hr.IIIID 'I••X.I 

_1/1 

AlG 

IIA'IIO 

BLOOD

_1/1 -­......- 1.11'1'" 

./IIL 

' •• 5 1'.99 3.34 1.'4 3.11 l'S.I' 

S'.I 1.22 3." 1.'2 3.15 133.1Ii0 

' ••3 '.37 s.:n •••• 3.15 1".13 

'Z.3 '.U 3.53 0.16 3.lS 121.!! 

12.2 7.19 3." 1.07 3.e. 141.72 

".0 10.15 4.1.3 0." ••27 L47.711i 

'J.t lIi.n 3.57 1.07 ••03 15'••5 

' ••2 7.2. 3.0S 1.02 3.0. 151." 

' ••0 '.12 3.•' 1.03 3.a. 1".13 

II.' 11.:1' 2." 1.02 3.U L".10 

~GULATORY~RT - 293 
•• 

•• 

90 DAY INHAlATION TOXICl'Y STUDY IN THB RAT wrmRECOVERY PHASE 

APPENDIX 9 - INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

QIIOUP. 3 DOD LIMU.. 300 ... sa.......... 


l'UIIIIA .ro.... I'IioAIIHI. .L&SA ,wuaa n.ua 
 .ua. 

MIIIU. au an: HJI UP UI' c:.u.c:n. C1118'1!1& ClII: Cll/1IlD ..... 110 mil. tv/l tv/l -Vl. ~/l. mil _l./l. 

11 .. 14, leI .a UI 2.72 1.a. 214 43 

12 :r It 47 '0 2.'. 1.711 18, 41 " 13 :r 14 102 71 .2 2." 1.U 131 .u 


u .. 14. 10' 71 104 2." 1.12 17 41 


IS :r 14 111. 106 2.74 2.04 10$ 
 '" 16 .. 14 Ut n 7t 2.7! 2.alI a. 42 


17 .. 14. 113 91 II 2.a1 2.16 112 41 


II r 14, u ,a 11 2.11 1.18 1.07 n 


It .. 14 101 70 2.1' 1.'1'3 n so 


to .. 14 1145 77 ., 2... 2.02 53 tlt 


REGULATORY/REPORT . 294 

90 DAY INHAL~TION TOXIcrY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 9 - INDIVIDUAL BLOOD CLINICAL CHEMISTRY 

GIOUJ'. 3 D08II L_. 3DO .... sa. I'IIIALI 

PLliSIII. PLAIIIIA Ho.UaA PLliSIII. PL&IIID. I'LUIII. n.a.tIIII. 

AIIJIDL _.. IIU IIDII: ca.UCOD e,UDII PO'I/I1II IIClDIUII _I" ftIlG8 1II1II&

ItO -~/~ _~/l _1/1 ~/l -~/~ _l/~ -U~

11 P l' .., 103 ,.... U3 1.11 0 ••7 I.U 


12 P U 12.4 104 '.7' leI 2.41 e.n 7.'. 


u P 14 10.2 102 S." US 0.72 6,"
 I.'" 14 1.3.6 10 .. 4.07 Its 2.0t 0.71 '1'.0. " • 

I., 14 ••1 103 5.2' 142 2.50 O • .,. ~.1' • 

III r 14 '.1 10' '.70 Itl 1.111 0.611 T.'l 


17 14 U.2 10' S.U 1" 1.2' 1.01 t.70
 • 

, II 14 11.7 103 ,.,' 1'0 1.2' 0.1'1' '.35 

., , 14 14.' 100 '.t? 140 1.79 0.'2 '1'.47 

, to 14 111.7 102 ,.... In 1.61 0.'2 5.21 

REGULATORYflUWORT - 295 
-- --

90 DAY INHAIATION TOXICIY STUDY IN THE RAT WITH RECOVERY PHASE 


APPENDIX 9 - INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

GIOGl'. 3 D08I Lnu.. 300 JISlIl SD:. PIIIIAr.II 

....... I'LUID .LA8III. Ir.a&IA "/8 :ar.tJOe lIIOSH- UDI&L so: AJ.BOJmI '!'.nor 8-111" ,;.:aXLI &';10 LJ.IDiI ..... 110 ./1 ./1 IV/l. _1/1 ~11 ",IDf. 

, u U 31." 5I.t S.II ',)3 1.21 ".Oil 18..... 


12 U n.7 n .• 7.n 2.11 1.1. ,... UII.II
 • 

, as It 31.2 61.1 6. lit 2.r6 1.011 '.21 U7.S.

.. , 14 31.' n.1I t.Ot 3;12 1.17 3.31 "'0.13 

., p 1. 30.1 57.7 5.0' 3." 1.13 3.31 152••' 

, .1 U 30.' 10.' 6.50 a.s. 1.02 3.51 157.11 

, 17 U n.7 60•• '1'.37 a.n l.a. ..01 1117.11 . 


II U 31 •• 61.7 ••'3 .,'2 1.00 3.Ia 152.20
 • 

, II 14 3a ... n.' 5.27 n 1.10 UI.11' 3 ••' 


10 • 14 32.' 63•• •• 55 2." I." 2 ••' "'3.1'1 


RWUlATORY/REPORT - 296 
90 DAY INHALAnON TOXlCfY STUDY IN TEE RAT WITH RECOVERY PHASE 

GIIOUFI ,

lID. IlAJoII 

AllIIIaL OJ: 

.­ -.,

1I1 14
 • 


:sa 14
 • 

33 14
 • 


3' 14
 • 
 II 14
 • 
 36 14
 • 


37 14
 • JI 16
 • 

3t • l' 

to 14
 • 


D08I LDIUo. 

'LUIa u.1' 

lUll 


1" 


201 


UJ 


147 


17. 


III 


lU 


U6 


176 


151 


APPENDIX 9· INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

1000 ppa 

l'LIIiIIIIIa l'J'.IJIIII. ....!IIIl. l'J'.IJIIII. I'w..a. :n..II8IIII J.L~ aft c:.AICDM Cll/a'l'Jll. CIt call1'Dlll 

GIl IVII -u/l _1/1 IV!l _1/1 

7S n 2.U 2.17 140 J. 

.S 131 2.tO 1.61 111 al 

" 2.11 2.11 :r7 '!I " 

6S 103 2.67 1.65 1111 3. 


,. 106 2.t6 2.71 111 II 


103 1" 2.1' 2.02 212 
 '" 7. 101 2." 2.21 US '2 

7G IS 2." 2.It 137 40


103 ., 2." 1.U 164 


" .. 

" 71 t7 2.1" 2.37 

REGULATORynuwORT - 297 
LLI 

~ 

; 

Il. 

t;: 

~ 

Ii; 


Si ., 0 .. .. ..,
 w .. .. .. • ... ... • Iii •. •

• • E x 

• ":

... .. .. 

•

.. .. • .. ... " ..

~ 

~ (.) 

~ (.) .. .. ., .. .. .. - I;~ 0 .. .. " .. 0 ... ..

• .... •. .. . .. ~ z 

:J 

1.. .; ... .- .. .. ... .. .. .. a:i (.) 

Q II

'''' 

~ 0 .. .. Iii ..•

. .. •

,.j ..

~ 

•.. 

Of 

.. ..• ..

.. .. "

.. .. •

"!: III 

t 

.; ,.j 

ID 

9 .. .. 0 0 

.. 

§ c1 I .... 

I 

~ Q 

::> Iii .... .... ..

.. .. ..

.. .. 

.-I 

.. ..

III ...

.. ..

.. ... .. .. .. .." ... .. .. .. .. ~ .. Z !.-I -

Q 

• .. .. • ... .. ... ...

.. ..

.. .... ... 0 III "! 0 G) -: . Iii • 

.. .. .. .;'" 01 .." .. 01 .. .; 

)( .. -Q ~ z ~ ·w 

a. I s!~.... .-I .. .. .. .. Of 

0 ~;;I 0 0 0 0 0 0 0 0 

0 .. .. .. ~ ~ • ... ... ~ ~ ... .. ... .. ... •

0 

0 

.. .. .. .. II! '! ": "l "! • i 

... 

li~ .. 0 .. ..

.. .. 0 0 .. ... 

. .. dl • .. .. .. .. .-I 

I 

:i Ii .... ..

... ..

... ..

... :i ..

.. ..

... ..

... ...

... ...

.. 

is s • • • • • • • • • • 

~I ... ., .. ., ..., ... 

.. .,• .. 

fit .. III III 0

" '" '" '" 

~ M 

~ 

2 

:i>' 

~ 

~ 

~ 
90 DAY INHALATION TOXIClY STUDY IN THE RAT WITH ROCOVERY PHASE 

APPENDIX 9 • INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

GIOal'I .. DO.. L...... 1000 ppa 

BIZ. xu. 

I'L.UIID. I'LIIIG Ir.IIaIII. PLll.8llll. I/il Br.oou ......­ lIIIDL BIZ ... Af.8UJIJII :r.•1ICW 80ft ~.IU.t _~JO UJII& • LlnDII 

110 ,II ,II lUll _1/1 _111 III/IIL 

--31 11 14 a'.7 n.1 7.'6 3.1:t 0." 3.lIt 141.51 

U II 14 :u•• ".3 '.61 ',Ja 1.02 ~.61 1101.51 

.u II 14 33.1 63.7 7.25 ••ell 1.01 3.oa 1116.17 

3. II U 10.' 6'.5 10••' 
 3.l1li 0.'1 3.'" In.55

IS II 14 33.2 63.6 4.10 3.12 1." 3.4.1 :&'71.72 


56 14 29.5 60•• 5.11 U •• 51
 • 5 ••' •••• 3." 37 II It u .• 65.6 6.11 2.44 0." S... 131.65 


31 16 12.6 tla.a ••ss ~.~ 1.U 3." 14<1.12
 • 31 I( 14 aI.5 .2.0 6.51 .... 07 0." 3.'7 131.2.1 

...0 14 U.6 62 •• 7.20 3.17 1.01 2.'3 111.403 • 

~GULATORY~ORT - 299 
•• 

90 DAY INHALATIONTOXICIY STUDY IN THE RAT WITH RECOVERY PHASE 


APPENDIX 9 - INDMDUAL BLOOD CLiNCAL CHEMISTRY 

&OVI'. e DOIIK LJIVU.. 1000 .... IID:. l'IIIILII 

pLll.lllQ. Pr..LIIID. I'W8IIlo PLISIA l'LUBI. n.&8IQ. ...... ---U r 

AlIDIU. SU ... u.P &'1' Aft C&IoCI... at/8ft1 CI: CIl/mlll 110 mil lV/I lUll _1/.1 -0111 1Ut'1 _Ill 

U 143 57 '1 2.n 2.3:1 a:J so 

n r 14 II 4~ a.u a.3' n t:i 

'3 r 14 1$ e. n 2.'5 a.u 5'7 u 

Ie r 14 11e .. 2.'3 1.,e '0 u '1

IS , 14 lle 7t 1., 2.1ll 1.U U 40 


" r Ie n M 111 a.'5 a.0'7 la 44 


17 r Ie e1 72 a.'" a.a4 13 44 


t' , 14 11' 

" .7 .3 2.ta 1." n ..e 


tt r 14 ., M a.n 2.431 I. :It
 " 100 r 14 .e .1 100 .1.77 a.ao '71 .a 

RBGULATORY~ORT - 300 
90 DAY 1NHAlATION TOXICI'Y STUDY IN THE RATWITH RBOOVElY PHASE 

APPENDIX 9 -INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

GIIOOP. DOI1I LIIVBL. 1000 ~ 

SID: I I'BII&LIr " ..~ PLIUIIII. PLABIIl ...- ..LUIIa ..r.aaa ...-

JIIIIXll,L SIIlI: au GLUCO!R C/alDII J'O'I'/IUII 1OD:n.I JIIIOII,IIS 1UG8 UIIQ.

...... 110 _1/1 ~/1 _1/1 _1/1 _1/1 _1/1 ~/J 

91 r 1.. 10.1 116 5.0' 161 1.92 0.&1 1.91 

'2 r 1.. 16.0 117 5.50 161 1.6' 0.'2 7.16 

., lUI 16 10.3 1.. 4." 164 2 ••• 0.17 7.6' 

,. 

., 

., 


• 6 16 9.' U5 '.20 163 I.' • 0.16 7 ••2


., 4.,. 'S U- 11.2 113 1 .. 2 2 .... 0." 7 .... 

14 7.1 If" 143 1.1t o.ts 1.21 ' ••7 

., 

" 

'7 14 9.1 US 3.'2 143 1.21 1.65 7.93 


II P 16 11.2 III 3.70 1ft. 2.U 0.12 7.1:1 


P It 13.3 113 3.1' 1 .. 1 1.3. o.n 6.61 


100 P 14 16.1 1f3 3.5' 143 1.'4 0.15 5.'5 

ltEGULATORY/REPORT • 301 
90 DAY INHAlATION TOXIC::Y STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 9 .. INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

1DtOVP. t IIOdIII LIIvm:.. 1000 


dlt. J'IIID.I'oI: 


1'L.UIIA l't.UIIa l'LUIf& l'LlaI. &/8 lloOID PIID8l'II­

... ~ 

IIIDIlL aD UBIIIIl. ~.1'IIm G-Ift '.SILI Dno UIIIIt. • r.lnN JIG "I ,/l. IO/l _l./l _Ill. ./M.

-91 r u 32.' a.t 6.tO Zo" 1.11 t.lI 16••32

92 I' U 33.0 a.3 6.'7. :It. 62 1.12 3.313 151.82 

'3 II 14 :s.... 117.5 6.10 :S.U 1.11 3.$t 151.12 

... ,. It 32.3 42:.1 6.62 3.51 1.0' 3.70 116.19 


IS I' U 31.5 ,.,1 5.22 2." 1.11 3.46 131.76 


I' 14 32,' 11.1 6.U J." 1.16 3 111.os
 ..' " 

., I' U 31.7 63.1 7.93 3." o ••t :1.70 1$7.'3 

II r u 33.0 6.10 1.01 U'7.02 Il.' 3.'3 3." 

., I' U 31.1 n.t I.:tl 3.12 1.0' 3.13 1'72." 

100 I' U 32.1 M.' 1.35 3.2'7 1.12 2.71 111."2

RBGULATORY/REPORT - 302 
90 DAY INHALATIONTOXIcrYSTUDY IN THE RAT WITH REO>VERY PHASE 

APPENDIX 9 .. INDIVIDUAL BLOOD CLINICAL CHEMISTRY 

IIIOUJ'. 5 

IU. III\LII DOI1I LKYIIL. 0 PPI 

UlIIGL

...-

SIIll ...

., J'LAIlIID. 

I.LlI' 

lUll 

J'LUIIA 

11.'1' 

lVll 

J'LlUIIA 

Aft 

rull 

Ir..I8IIA 

c::IloC:I:WI 

_111 

I'L.t.II\III. 

CIlI­ _1/1 

:ruaa. 

a 

18/1 

l'f.UIa 

c:a/llIIIII 

~/l 

U II 11 170 I. to 2.71 2.411 '71 17 

U II 11 210 201 166 2.1t 2.11 .0 3!J 

43 II 11 1'" 115 It 2." 2.'3 It I' 

,.. II 1. Ut 115 141 2.7' 2." 72 3t 

'15 II 1. 227 116 13' 2.'2 3.211 .0 3t 

U II II 202 laO 1 .... 2.10 2." 113 3. 

47 .. 1. 1" I. 2lS 2." 3.10 10. 411 

... II 11 170 101 tI 2.'0 2." •• ,. It .. 11 IISJ III 142 I .... 2.71 100 47 

50 II 11 111 I. I" l.tI 2.2' 101 ,. 

~OULAroRY~ORT - 303 
•• • 

90 DAY INHALATION TOXICl'Y STUDY IN THE RAT WITH RECOVERY PHASE 

I\lIIOIJI' • IS 

sa..... 

JJlDIAL sa RID: ...... 110 


U 11
 • 


ta 11
 • 


61 18
 • 
 U 11
 • 


.5 11
 • 

18 


..

n 11
 • 

• II 


'II 11
 • 
 50 11
 • 

DOIII LrI&. 

P~ 

ar.VCC81 

_Ill 

7.' 

'.2 

'.6 

7.7 

7.' 

11.11 

'.1 

1.1 

1'.4 

'.3 

APPENDIX 9 - INDMDUAL BLOOD CLINICAL CHEMISTRY 

0 ,.. :I'LAIIB. ........ _x. I'LUIIIa ........ PLUIa 


-C/JU:DS .ar/11lll "'/H .:rea .... _111 _111 _111 -UI ~Il ~/I 

102 4.'0 lU 1." 1.31 1.'3 


101 4.31 1t3 1." 1.U 7.13 


100 4.n 142 1.'7 1.37 '.57 


,. 
 '.n lU 1.114 D... 1.11 


" •.n lU 2.2. I.U 1.6' 


101 •• SS 161 1.55 1.71 7.73 


104 I." 142 1." O.t., •.U 


lOt '.65 143 
 1." 0." '.5' 

lOt 11.24 140 2.2' 0." '.12 

10f 11.77 lU 2." 1.25 I,ll 

IREGUlATORY/REPORT - 304 
90 DAY INHALATION TOXICI'Y STUDY IN THE RAT WITII RECOVERY PHASE 


APPENDIX 9 .. INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

...... 5 

IU, IIIILII 

DOIIII r&¥IIL • 0 WJIIIIDL

-­ SJDI. IIIIU 

110 

.1oiUIIm 

ALIIUIIDI 

gil 

I'LUID. 

r • PIlOt' ,,~ 

rw.IIa 

8-B 

18/1 

.~ 

' ••ILI _~/l 

All;, uuo IILOGD 

VUllo­

-1I~ 

.....- LI.IDI 

./DL 

n II 11 32 •• 6'.2 1.15 3.:17 0." 3.14 'I'.n u II II 31.1 6'.0 6.S6 3.13 0." 3.13 tlO.57 

.. 3 

u 

II 

II 

11 

II 

31.3 

31.1 

61.' 

,... 6.31 

7.'6 

3.11 

3.21 

0.'1 

1." 

3.n 

2.111 

tll.27 

l70." 

t5 II II 31.1 61.1 1.5:1. 4.31 0.,6 3.L2 ' ....1 

.6 II 11 33.0 67.7 6 ••' 3.67 0.1111 3.n 1403 ••• 

n 

U 

II 

II 

11 

11 

31 ... 

33.1 

61 •• 

65.1 

6.62, 

7.n 

3.'" 

3.'3 

0.'. 

1.'2, 

3.U 

..,. 

1'0.11 

111.'3 

.., II II :u.o 61.1 6." 2,••1 1 .... 3.7. 161.26 

50 II II 32.0 6&.3 1'.11 3.10 0." 3.03 1117.11 

REGULATORYAWPORT - 305 

-- •• 

•• 

•• 

90 DAY INHAlATION TOXICTY STLl>Y IN TIlE RAT WDlI RECOVERY PHASE 

APPENDIX 9 • INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

cmou.. 5 D08JI UYIIIo. 0 ... SUI PaHoB 

.urJllAL lID 

.LAIIII. 

ALl' 

.r..IIIIIII. 

AliI' 

.LABIII 

.a8'I' II.UMI. ct.r.C11III 

I'L.lI8A 

Cl/.I'IL. .a8IIA 

ell: ~ 

...... ... 111/1 111'11 111'/1 .01./1 ~/.1 lV/l _1/1 

101 p 1. 77 ,. 3.01 2.54 n 3. 

192 11 1. n r1 n 2.113 2.61 .5 U 

103 r 1. n 13 10. 3.01 :l.u III to 

104 r 18 SI 70 2:••• 1.111 .. .. 105 11 18 115 17 n 3.03 2.U 62 42 

10. r 1. 1111 104 l.'75 1.01 13 U

" 107 11 18 164 .7 11. l ••• 2.01 17 4. 

10. r 1. 117 77 1115 3.01 2.2l1 as .0 


let r 1. 77 11 .•7 :a.U 2.33 40
 " 110 r 1. 110 n 131 3.00 2.00 lit 

IREGULATORY/REPORT • 306 
90 DAY INHAlATION TOXICl'Y STUDY IN THE RAT wrm RECOVERY PHASE 

APPENDIX 9 • INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

GIOUP. 5 lI08II r..vIIL. 0 PJIIIl 


IU.I J'lIIIlU'.Ii 


p~ 1'L.IiIIIA I'LUIA l'~ l'LUIII. PL&IIDo I'LMIIIIl AIIIIDJ'e sa: DB GLUCOI!II CfttUill 1Om/I'llil HDIW QOS/. 'I'IXU JIUIDIIIII 

101 I' II 

110 _loll. 

12.6 103 

_l/l. _111 

•• 32 U3 

~/l 

1.0' 

_111 

1.0. 

.ol/l 

'.00 

_1/1 

- 102 I' 11 15 •• 105 U7 l..l1 1.11 7.2.6 '.!II!! 

103 I' II 16.3 '7 
 .... lU 2.0' o.,tI 1.56

101 I' 11 11.0 101 ••2' U2 1.13 0.74 
 7••' 

., 105 II 17 •• 102 •• 43 1U 2.2.6 O.lIt '.03 


101 I' 11 tI.O loa '.36 lU 1.11 0.97 7.2' 


107 I' II 15.3 101 6.21 1405 1.111 1.21 ••75 


101 I' II 11.1 lOG 3.71 US 2.22 0.'. tI ••3 


10' I' 11 12.' 101 4.ot 1U 1.40 1.:11 7.n 


110 I' II ',I ttl 6.16 UO 2.'3 0.67 •.U 


IREGUlATORY/REPORT - 307 
90 DAY 1NHALATION TOXICI'Y STUDY IN THE RAT WITH RECOVERY PHASE 


APPENDIX 9 • INDIVIDUAL BLOOD CLINICAL CHEMISTRY 

GIIIOD. a DOSI 1II91IL. 0 p,. so:. J'IIIlUdI 

....... 1'1'.loIII). 1'1oASa ....... IIJG BLOOD ....... 
 MJJD.I'. IIBlI: ., AU8IWf ".ftO'J.' G-n ".BU.! ...,,!O r.UIH

.... - ell ell mIl _1/1 _1/1 -­ _iDr. 

101 l' U 311.11 67.0 7.46 3.SIl 1.12 :l.U 171.99 

102 l' 11 33.' 61•• 7••7 3." 1.11 S.39 1".11 

103 U 31.1 7.26 3.0' 1.11 3." 1'2.21 ., 

".. , 10"' 1. 33.' n.~ 7.40 3.27 I.U 3.n 11".70 

1011 , U 33•• 61.1 '.Ui :t.'7:I 1.06 1.11 172.30 

106 , U 32.1 ".2 I.U 2 ... l.as 3.60 1114.112 

, 10' 11 33.1 63.J I." 3.71 1.11 1.111 U4.19 

., 101 11 !f..II 61•• 7.11 :J.U 1.22. 4.10 164." 

., lOt U :11.7 ".1 1.10 3." 1.16 3.a. II!." 

110 l' 11 3:1.1 .... 6.U 3.10 1.11 3.'3 164.11 

IREGUlATOllY/RBPORT - 308 
• •• 

90 DAYINHALATION 1'OXICIT STUDY IN THE RA1' WITH RECOVERY PHASE 


APPENDIX 9 .. INDIVIDUAL BL.OOD CUNICAL CHEMISTRY 

aOUP. I IlOfIJI IoI"I'IU.• loeo PIll 
 .... IIBLS 


l'LUID I'1ioaIIU. 'J.UIII, PLAIDIA ......... 'L&Sa I'foAIIKII. 


AIIIlLUa SSI[ a:JIJC 	 ArJ ~ AS" ~ Clt/_ CII: ta/1DJa

Nil IVll. lUll ~!). -.1/), XVIl .ol}l --51 1a - 194 10' 91 2.U a.:u· II 31 • 52 X 11 201 	 .. 	 101 2.15 S.I' .to ,. 

53 • 11 232 132 1" 2.14 a.ll u, 3'

U l' 1411 U I' 2.11 l.'3 163 U • SII X 11 no 16 101 Z.?I 2.U 12. 36 

SII 11 1'7' 12 10. a.u 2.17 	 ., • 	 '1

n Ie 110 lOT 130 Z.U 	 :I..,. 113 41 • 

,. S. 11 116 	 2 ••• ~.lU. 60 3' 

• 	 ,., S' 11 1'" It t1 2.13 I.U 711 

10 X 11 U7 ,5 	 I.n l.U IT 3' " 

KEGULATORY~PORT - 309 
90 DAY INHALATION TOXICTY STUDY IN THE RAT WITH RECOVERY PHASB 


APPENDIX 9 • INDIVIDUAL BLOOD CLINICAL CHEMISTRY 

GaaU'I'. 1\ DOIAI UQI,. 1000 lisPI, ....... 


Pr.UIIk I'LA8IIiIo 'IoAIIIIl ,....". .....-a. ...... I'!oI8IA ..aar. tAlI .... GIoVCOSII CIUU J'OI'n;UIoI 'IIOI/UII WIllG& vua ...... 110 _1/1 _l/1 _1/1 _1/1 "l11li _1/1 _lIl -.1/1 

,II .. 11 1.2 100 •. n 141 L.IO 1.314 1••4 

sa .. II I.' 101 4,111 143 L.'4 1.21 7.00 

on II II 10.lf 101 4.01 US J.H 0." '.4111 

,.. II 11 12.5 ,. 143 :1.11 1.0' ,.03 4. " 


.IS 11 1.3 100 4.n 143 Z.SI 1.03 
 '.11 " 116 .. II 11.6 102 '.61 143 1.60 1.17 '.311 


51 11 '.1 100 ••01 1... L." 20,00 7,21
 • II .. 11 11.' too 131 1.14 0." ..., II••" 


III II II 100 4.'0 1'102 0.71 6.7'
 ••• I." 

10 II II 7.3 101 4.02 143 ••U 7.n I." 

fRIDUlATOltYIREPORT - 310 
90 DAY INHAlATION TOXICTY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 9 • INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

, CIlOUI'. DOSI LIrVJIL. 1000 P'­ BU. BLI: 

PLIUIIII. I'LIIID PL&BIIIr. PLIIIIII. AI. IILO(D notmIUlJ1III.L au wac .l.LlJ'lD(U '!' .1'IlO'r G-ft '.BUI UlJ:O UUA • LIPIDa 

IJO gIl ,11 IV/l ~/J. _1'1 IIIiI/DL 

-51 :II II 33." ".0 2.41 3 ••• 1.02 3.71 111.'. 

52 :II 11 n." ,.... '.37 3.10 i.Ol 3.17 1'.....0 


13 II II 30 •• 'I.a 7." ".07 0.13 3.'3 111.11 


I .. II 11 30.3 II.' '.n 3.0. 1.07 3.11 13'.3'


III II 11 31.' ".3 ' ••1 ...14 1.10 2.1. 11:l.12 

., II la 32.' It., '.01 3.'0 0." a.', 1....17 

57 II 11 :12.1 ,.... 5.'" 3.13 0." 3.37 1'••42 


&I II II 't.1 '.71 3.011 0 .... 3.11 1.0••7
 2•• " 

51 I( 11 3:1.7 ,~ ... 7.0' ".31 1.03 3.15 11••:11 


10 I( 11 30.1 !I'.l 7.31 3.'" 1.01 3. sa 117.'" 


~GULATORYnrnPORT - 311 
90 DAY INHAlATION TOXlcrY SIUDY IN 11IE RAT WITH RECOVERY PHASE 

APPENDIX 9 • INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

_ DIll.

-

CIIOUF. ~ 

SQ, J'II8LI: 

SQ ... 

110 

DOH ......,.. 

.r..taIll .u,p 

011 

1000 ppa 

:tr.a.8III. 

llo'I 

1./1 

l'I'oAIIla 

U'I 

tvll 

tLMD 

Q1.C1'UII 

~/l 

PLaIIIG c:.J_ 

-.1/1 

........ ca: 

ofl 

ftoUIIA 

CII/IIlIIII 

~/l 

111 ., 18­ 112 61 ,. 2.1' 2.U 7 .. .. 111 r II 'I ... Ui 3.1' 2.77 1311 ~. 

113 ., 18 107 166 210 3.01 2 .... 72. ~, 

114 r II 12 .. 16& 1t2 2." 2.2' U ~3 

liS r II n " 1!17 2.71 2."3 " 43 

11' P II 112 1_ a., a •• ' 1." 112 U 

117 ., 11 " 17 7111 2.T' 1.13 73 31 

UI P 1. 117 71 12.. 2.11 2.73 " 4. 

11' P 11 102 166 300 3.0" 2.4& 57 41 

1:1141 P II 101 ... 73 2.'" 2.13 66 41 

'RBOUIATORY/REPORT ~ JU 
90 DAY INHALATION TOXICTYSTIIDYIN TIlERAT WJfH REroVERY PHASE 

APPENDIX 9 .. INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

CIIIClU1'. 6 DOS:I ::.II'f'Do. 1000 ua 


1IIIa • .-..s 


........ I'r..ua .t.uD PLA8l, ........ ...... I'Io.UU. 


M'lIIU ID ....: GL1IC08B C/IUIII H'f/l1lll SIXlIW :nos/_ ftD18 ..... ....... 110 _1/1 _111 _111 -Ul _1.11 _1'1 _1/1 

111 r 11 '.2 104. 4.ao U4 1.60 0.1'7 '7.n 

112 r II 2C.2 10C 5.15 u. l.U O. '71 '.U'­

113 r 1. 13.' 103 3.11 US l ••' 
 0.'71 5.'2

llC r 1. •• 5 101 5.U "2 1.54 o.n 6." 


115 r II 13.1 6.13 131 I.U 0.6' '7.'. 


11. p 18 12.2 101 4.U U3 l.U 0.'70 '.a. 

117 r 11 '.7 100 4,27 143 1.26 1.35 I.IC ll. r II 12 •• 101 4.11 U2 l.tI 0.60 •• 50

" 

., 11 14•• 100 4.61 144 0.6' l.'" 11' ..,'

120 r 11 11.1 104 4.41 141 l.U 0.5. 5.11 

IREGUlATORY/REPORT - 313 
90 DAY INHALATION TOXICIY STUDY IN THE RAT WITH REOOVERY PHASE 


APPENDIX 9 • INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

1i1IO'CQ', I D08I LKftL. 10" .... SU............ 


~. .....,. .......... .......... 11./& BLOOI JII08"~ AIIIUL lID: 

.., 

AloIIUImI ".~ Qo4! " ..UI "'''10 IOUIDII

..... .... II/I II/I 11111 _1/1 _111 -- .,.

111 I' 11 II.! 16.6 7.21 3.11 1.13 3.71 a ••• u 

11:1 r II 31.' 'I.a: 7.4:1 2.U 1.0' 1I.1S no." 


ll! p 11 11'.1 66.a 1.30 1I.la 1.0' 2." 117.11 


., lit 11 :1'.0 ".! 7.66 2. ,. 1.12 3.2S U7.:J2 


115 .. 11 31.0 n.a 6.31 11.01 1.14 :I.n 111.27 


., 
 11' 11 33.1 n.l 5.1' 11.'5 1.1:1 '.111 1".0:1


117 .. 11 ".1 ".11 I.IIS 3." I.U •• U Itl.21 


111 P! 11 33.:1 13.11 '.'5 11.013 1.11 11.'1 ltO.1? 


11' P! U It.' II.' 6.10 3.'" 1.0a 1I.2T 111." 


1:1. P! II 3!.' ",I ....5 1.10 2.71 UlI.12 '.n 

IREGULATORY/RBPORT - 314 
• • 

90 DAY INHAIATION TOXICTY STUDY IN THE RAT WITH RECOVERY PHASE 


APPENDIX 9 - INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

GI:01I:.. 1 D08I LKYIIL. ppa • 

SU:. KU.II 

LlYIDl 

AIIDfU. sa: lPCGI. -. 

• 

-

110 
 -,.,.

If 14 0.:186 


, it • •. n' 

14 0.232 

!Ii' If It 0."'" 

10 1. ••!PI • 

~GUlATORY/RE1ORT . 315 
~ 

i 

~ 

~ 

w 

-
 0\ 

~ : : :: := Ii .. .. .. .. .. ! ~I .. "" ..All •

"" ... .. ..• !II i: 

.. I 

r 

~ ~ ~ ~ ~ tiS 

,.. Will... ... ... • 

: t :: :: : ii' 

• ~ I 'V 

m 

Z 

C 

X 

U) 

I 

Z c--

< 

c 

c 

)It 

r" 

6 

0 

c 

n 

I: zn 

~ n 

X 

m 

I: 

!i 

~ 

~ 

~ I< 

~ d 

~ 

d 

~ 

~ -< 

i 

~ 

~ ~. 

~ 

" 

~ 

-< 

~ 
90 DAY INHAlATION TOXICfY sruDY IN THE RAT WITH RECOVERY PHASE 

GIIOVP. Z 

SUI IIALI: 

UDII.I. SIlt ... ...... 110

16 .. U. 

17 .. 14 

11 II 14 

It .. 14 

zo .. 14 

APPENDIX 9 .. INDIVIDUAL BLOOD CLINICAL CHEMISTRY 

DOa:I LPIIL. 100 ppa 

LI9D.

_laI. 

-

0.154 

0.30' 

0.U4 

0.23:11 

O.,Ot 

IREGULATORY/REPORT - 317 

90 DAY INHAlATION TOXICfY STUDY IN nIB RATWlTH lWOOVERY PHASE 

APPENDIX 9 -INDIVIDUAL BLOOD CUMICAL CHEMISTRY 

GIIOUI'. I IIOBIl LSYlIL. 100 ~ 8:1][. FIIIDLII 

DlDL

-­ lID 

-

JI() 

LIYlIII 

.~ aa/.,. 

7t F U. 0.309 

77 ,. 14. 0.077 

71 ,. 14. o.ln 

7t ,. U 0.3.)2 

10 F U, 0.232 

/REGULATORYIR.EPORT • 318 

90 DAY INHALATION TOXICJY STIIDY IN THE RAT WlTIl RECOVERY PHASE 

APPENDIX 9 • INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

4iaOUI'. 3 DOSI r.n.u.. 31111 


1iU. ~ 

LlYR 

illlIGL lID: .c:oA 

110 -.III/a 

... 

Pa­

-26 • U 11.'77

27 U 0.617 • aa I 14 0.lt3 

2' I 14 0.077 

lit I 14 0.3011 

2/REGUlATORY/REPORT • 31!) 
•• 

•• 

90 DAY INHALATION TOXICI'Y STUDY IN TIlE RAT wrrn RECOVEl.Y PHASE 

APPENDIX 9 • INDIVIDUAL BLOOD CUNICAL CHEMISTRY 

QaOOI'. 3 DOD LlIVBL. 3.0 ... IID.~ 

LIYDI 

UDIAL lID ... .cal.

IIUIIIIJIIl 110 -'./8

., 	 r 14 0.30' 

.7 	 r 14 0.017 


r 14 O.lUo 


r 14 1.15• 


.0 	 r 14 0.017 

IREGUlATORY/REPORT - 320 
90 DAY INHALATION TOXIcrY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 9 - INDMDUAL BLOOD CLINICAL CHEMISTRY 

~. 4 DOh: .L1I'9IDo. 1000 .... SIIlI:. IIU.I 

Lrna

8lIfA£ BBa ... !'Col.. JIO ~.,u 

-

36 II 14 0.077 

37 II 14 0.017 

3. .. It 0.113 

:It II 14 a.3e, 

40 .. 14 0.077 

IftEGULATORY/REPORT • 321 
90 DAY INHALATIONTOXICl'Y STUDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 9 • t4DIVIDUAL BLOOD CLINICAL CHEMISTRY 

GIlOVP • 

IIlUI: • I'II:IIIIiLS 

• 110IIII LSUL. 10&0 SIsAIIDfAL

..... ., 

IU 

, -

110 

14 

LIYU 

l'CoA 

-'-/" 

0.077 

.7 , 14 O.lU 

,. r 14 0.15& 

,. , 14 11.30' 

100 F 14 11.15' 

~GUlATORY/R.EPORT - 322 
90 DAY INHALC\TION TOXICI'Y STUDY IN THE RAT WITH RECOVERY PHASE 


APPENDIX 10 -INDIVIDUAL URINE CUNICAL CHEMISTRY 

Key: 


The following abbreviations may appear in this Appendix. 


M - male 

F - fema:.e 

NO - number 

Y - yellow 

URO/GEN - urobilinogen 

B/RUBIN - bilirubin 

BLD - blood 

B CELLS - blood cells 

E!IHIAL - epithelial 

~ - negative 

+ ) Represent an arbitrary scale 

++ ) of increasing presence of a 

+++) urinary parameter. 

Ifthere are text comments further desatbing the appearance of the urine they are shown at the back: of this Appendix. 

~GULATORY~ORT - 3D 
90 DAY INHAlATION TOXJClY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 10 .. INDIVIDUAL URINE CUNICAL CHEMISTRY 

GlO1II'. 1 DOIII LCfBt.. Q ... ..:. MI.II 

UhU- uua VllDIII 11111. VIIJ.a 111101 _DIll 

Mnw:. .. .... .uKlJI ct£0lIIt wr.... 8(; .. 6lLI1COU .~QJJI

110 at 

-

1 • 13 10..." !' 1'1.0 1.':U •••• .. .... 2 • 1.:1 IOIIIJlo Y 7.8 1.(3. ..36 JIlIQ ... 3 13 JOIIIIiI.Io I 1t.0 1.U. JI:IG II8S • '.'7 

, .. 13 JOmw. Y I.a 1 ••11 7.17 .. .. 

!I • 13 ...... I n.1I l.~U 7.... .. ... .. 13 IIOIIIDI. Y '.0 1 .•1 7.18 .. .. • 

7 II 13 ~ Y 7.0 1.01:1 7.03 ... DO 

13 110....... Y 21\ •• 1.«'" 'I'.U DC
 • • .. 

• .. 13 IO&IIU. Y 13.0 1 ••• 7.11 .... .. 
 10 13 IIOJIDI. I 12•• l.U' 7.11 IllIG 
 ... • 

~GULATORYnmrORT - 324 
• • 

90 DAY INHAlATION TOXICfY SfUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 10· INDIVIDUAL URINE CUNICAL CHEMISTRY 

~. 1 D08II ...."..... 0 pa- SO:. IIU& 

DID nnn RID DDII &IDIU. so: WIlD ~ BLOOD PIIO'RD u.)/1ID 

..... 110 _1/1

1 II 13 mea IllIG +. 3.2 

:a .. 13 fIUI.ClI: ftactI +t 3.1I 

3 II 13 IIR IllIG + 3.1I 

.. .. 13 + .. ++ 3.2 

5 .. 13 IIR + 3.2 

, .. 13 IllIG ­ ++ 3.2 


'7 II 13 IIJIG +t 3.1I 


13 UCI JIIIG + 3.2 


t II 13 DACII lin ... 3.2 


10 II 13 \'U.CII lin ++ 3.2 


~ULATORY~ORT - 325 
90 DAY INHALATION TOXlC1Y STUDY IN THE RAT wrm: RECOVERY PHASE 

APPENDIX 10 • INDIVIDUAL URINE CUNICAL CHEMISTRY 

GIIIOVI'. 1 D:I8lI LIfnIL. 0 PPI 


BU........ 


:.uoJopa. ..... IrJtJ:IG mil. -- 8DU VIIDDI 

aIIllf.& 8a. 	..- UI<:I eor.ou YOL.. BIiI JIll GLOClO8I .'....1. 10 al 

---

6J U C£OOI)!" r 15.0 1.•,3 ••S­ ., ... ... I' U 1IO'IMlI.t. 1 	 1,•• 	 1 .•11 t.n mIG ...

6" " 	 7' U 110....... r L".'III t.OLS t.U. .. dO 


... p 	 u IIOI1111L 't n .• 1.'111,6 	 '.11 .. dO 

65 11 CLQIUD'r l' I1.S 1 ••17 6.73 11M IllIG

., ., 

P 1J ...... l' 2,.0 	 1.01' 6." 
 .. lIN

IT ., U ....... l' n.o 1.013 1.01 r.u.c:.& del 


., 6' U ....... l' 17•• 1.011 1.12 ... ..­ .. P 11 IIOJIIW. l' LO •• 1.0:&$ 5.'" IllIG ..

,. ., If IIOIIIIa.I'. 	 ., 	 ].f•• .1.0'1_ .... .. ..

2/REGULATORYIJ.tEPORT • 326 
90 DAY INHAlATION TOXICTY STUDY IN-THE RAT WITH RECOVERY PHASE 

APPENDIX 10· INDIVIDUAL URINE CUNICAL CHEMISTRY 

GIOVl'. 1 D081I LIIYJIL. 0 lisa 

-- sa.~ 

- vanr& mun 'lJllDIII 'IJIIDII UIJII,L sa D'rCJmIS BLOOD l'IIOUD' UiO/CIIIII 

110 _Ill 

U r 13 11M IIH + 3.1 


62 r 13 IIC KIIG Dac:JI 3.2 


53 I' 13 01; KIIG IIH 3.1I 


54 I' 13 IllIG lUG 'D&<3 :S.2


I' 13 .. lUG IU.ClI 3.2 " I' 13 DC ~ .. 3.2 " 

67 r 13 IIH ftM:I lid 3.2 6. I' 13 ... .. 'I'UCII 3.2 


69 r 13 IllIG IIH 'I'UCII 3.2 


70 r 13 IllIG JIJIC IllIG 3.2 

~GULATORY~PORT • 3Zl 
90 DAY INHAI.ATION TOXIClY S'IUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 10 -INDIVIDUAL URINE CUNICAL CHEMISTRY 

GIOOl'. % DOIII UYn. 100 ". lIDI JIU.II, 

.uPUIl- VRI:D ..:um ..u. IIIlIIIIi muD IJ2IR 

UDIAL lID IIIDJt AIIC3 CClLOVII 901._ M J.III GIoUCOIQi a/IIUJlD ., 111 

--11 .. 13 IIOaI.I. Y 20.0 1.12.. ".11 ... IIIICI

12 .. 13 IIO.ut.L Y 12.1 1.'27 1.40 IIBG ... 13 II 13 IOIIIIAL Y 11.0 1.12.3 1.02 KIIiGI ... U .. 13 ~ r '.0 1.C32 1." IllIG ... 
 15 13 IIOaI.I. r 11.0 1.'2% 1.%1 IIIIGI 
 ... • 11 .. 13 IIOIIIaL r 12.0 1.'23 1.'7 ... 11M 

17 • 13 IIOIIIaL r 11.0 1.12.% I." .. ..

18 13 IIOIIIIII.L Y •• 0 1.~31 1 ..... IIIIGI IIBG • 

19 .. 13 IIOIIIIII.L y 27.0 1.U3 1.'7 IIIIGI IIIIGI 

%0 .. 13 IIOIIIIII.L I' 42.0 1.UO 1.11 .. ... 

IREGUI..ATORY/REPORT - 328 
90 DAY INHAIATION rOXICfY STUDY IN 'I'HE RAT WlTIf RECOVERY PHASE 

APPENDIX 10 -INDMDUAL URINE CUNICAL CHEMISTRY 

GIIOUJ'. 2 D08I r..IIWL. 100 PPII 
 IIIZ. BLJI 


VJlIb VJIllIIi VJlIb Dr. InIIAIo sa; .... D!'<IIII8 BLOOD I'IIO'l'IiUl DO/_ ..... 1lO _lit

11 x 13 'DACB .. 3.2. 


12 X 13 !lIN an .... 3.~ 

13 X 13 'DACB IllIG ++ 3.1 


U X 13 ftt&CB .. ++ 3.%


15 X 13 BACII .. + 3.2.

16 X 13 ftACII .. :1.2

17 X 13 ftACII .. ++ :1.2

1. X 13 + JI1lG •• 3.2: 


19 13 IllIG 'DACI 3.:
 • 20 13 DG I'K DACII 3.a • 

~ULATORY~PORT - 329 
90 DAY INHAlATION TOXICfY STUDY IN DIE RAT WITH RECOVERY PHASE 

APPENDIX 10 -INDMDUAL URINE CUNICAL CHEMISTRY 

UlJIIIL

-71 

12 

7S 

,. 

15 

" 

11 

1. 

" aD 

GItOOt. 2 lID. l"IIIIU.B 

SD 

-

110 

J' 1lI 

J' 13 

J' 13 

., 13 

., 13 

r 13 

• 13 

., 1:1 

r 13 

r 1:1 

D081I UYIIL. 

.......­ It.IICZ 

IODJ,L 

IOaIIIlo 

IODJ,L 

IOIDL 

JOa'AI. 

JOa'AI. 

JOIU.L 

.,..... 

lIOaUo 

lIOIIIIIL 

100 .snIB 

C«aOIft 

l' 

l' 

l' 

l' 

l' 

l' 

Y 

l' 

l' 

Y 

VUDVOL_ 

III 

15.1 

13.0 

40.0 

17.1 

111.0 

11.0 

12•.5 

111.0 

11.0 

11.1 

nUl

.. 

1.019 

1.011 

1.0407 

1.017 

1.UI 

1.011 

1.0ao 

1.el9 

1 ••:1:1 

1.U' 

..l1li: aID

,. GI'.UCDIIII 

'.55 DC: 

•••• DC: 

'.23 DC: 

•.s. .. 1.03 ... 1.1.5 De 

1.24 .. 

'.11 . .. 

7.00 DC: 

7.11 .. 

awrII 

8/11UJ11l1 

DC: 

DC: 

.­

...

... 

...

..

..

... 

-­

VREGULATORY/REPORT • 330 
90 DAY INHALATION rOXICIY STUDY IN THE RAT WITH RECOVERY PHASB 

APPENDIX 10 -INDMDUAL URINE CUNICAL CHEMISTRY 

4aOUP. a DOSII: LBYKL. leO ... 111m• I'JIIIII.UI 

DDIlI nra ..DIll na::. _DII.L lID DYOIRS IILOOD HOnm no/_ ....... -

110 _1/1


11 I 13 lUG ..~ -.; 3.2 


72 I 13 IQIG IQIG tu.a 3.a 


'73 I 13 IQIG DV <> 3.:1


- '74 r 13 IQIG .. 3.1 


'75 r 13 IQIG IQIG 3.2


'76 I 13 lUG .. ­'!IllICIt S.l 


1'7 r 13 O~ ftW:I 9ACII 3.2 


'78 r 13 O~ IQIG '!IllICIt 3.1 


'79 r 13 OG .. 'IIIACII 3.1


10 r 13 IllIG .. IllIG 3.2 

mEGULATORY~PORT - 331 
90 DAY INHALATIONTOXICfY STUDY IN THE RAT wrmRECOVERY PHASE 

APPENDIX 10 -INDIVIDUAL URINE CUNICAL CHEMISTRY 

1ItOUJI. 3 DOSJI LDIIli. 3DO JIlIII 

IllS. IIAU 

U1IlD VIUJI1r 'UUD U1IDUI VIIl:_ DDIII

"'IDL .IIX ... AI'I''''- .uICII COLOR 110._ M pII GLUC08II .,...0 

lIUIIIID BO Ill. 

2.1 • 13 IIOI111U. 'I 10.11 1.0ao 1.41 .. ..

22 • 13 IIOIIIGL 'I 1.1 1.otO 1.11 .. ..

23 II 13 WOD&L 'I 10.1 l.8al 7.21 .. .. 2C 13 IIOIIIIU. l' 1.1 1.033 6.'4 ... ... • 211 II 13 .,IIIIIL 'I 16.0 1.023 1.12 ... ... a. 13 BOIIIIU. 'I 21.0 1.011 1.38 .. JaN • 

a7 II 13 ....... 'I 10.0 1.031 7.32 ... ... 
 28 II 13 JIOJIIIaL 'I 211 •• 1.011 7.11 DC! 
 ... 2. .. 13 .,IIIIIL 'I 1'.0 l.oao 1.69 ... JaN 


30 .. 13 BOIIIIU. 'I 23.0 1.016 1.51 ... JaN 


llEGULATORY/REPORT • 332 
•• 

90 DAYINH.ALATIONTOXIcrY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 10· ...DMDUAL URINE CUNICAL CHEMISTRY 

caouJ'. :I oos. LKYKL. 300 ... aBl...... 

UIlDIJI 1IIlDII ftDII: UllIn aJlDIIIL sa n:a KIftClIOSIl BIoOOD noD" U1t;)/CDIf

..... 110 
 _1/1

21 II 13 ftloCi IlK +< 3.2 


22 II 13 ftloCI + 1••0 


U II IS ftloCII 11M +i 3.2 


2' 13 ftloCI IIJI& 3.:1
 I( .i 

as I( 13 ftloCI IIBG ++ 3.2 


26 13 DG IIBG + 3.2
 • 

27 II IS .. ++ 3.2 

2. 13 DG 11M + 3.2 • 

2t 13 ftloCI lin + 3.2 • 

30 II 13 !DCI 11M 3.2 • 

~OULATORYnuwORT • 333 
90 DAY INHAlATION TOXIClY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 10 -INDIVIlUAL URINE CLINICAL CHEMISTRY 

GIIiaID'. 3 D08I ......... 300 ppa


IJIZ. FIIIIUJI 


unut- Dro UItlID uaID nlD 0l1li &.DIll 

'-DIU. au .... U'CII C1IJ,CRm 1'IIlILUIII IIG pM GliIlCOlUl a/_III

....- 110 111 

at J 13 8OaD.L Y 23.5 1.U' 6." DQ DC 

12 J 13 Y 12.1 1.tal 6.31 DQ DC 

13 J 13 -....... 'I 16.1 1.U2 ' ••1 DQ DC 


14 J 13 Y '.0 1.132 DQ IIIICI
 ' ••3 

II r 13 

-

:r 11•• l.n. '.11 .. ..

I. I 13 -110..... 'I II•• 1.UI 1.17 ... ..

.., 13 HIIlUIL Y 11.0 1.)27 1.26 IIIICI ..

I. r 13 JIQ1IIW'. Y 140.0 1.J22 1.1t ... .. ., r 13 Y 1'.0 1.tU 6.1t 
 .. .. to r 13 -IIOIIIaL Y 7.0 1 • .,1 ...,., 
 .. .. 

IREGULATORY/REPORT • 334 
•• 

•• 

90 DAY INHALATION TOXICfY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 10 .. INDMDUAL URINE CUNICAL CHEMISTRY 

GIDUJ'. 3 DOBII r&vBL. 380 PJIII 

811:1. I"III&U.I 

UIlID ..DIll aID 1JiII1D MIIIIL aD ICft<lIIIB JniOOI) PIIOI'IIII 

- RD," lItIIBa aD _Ill 

11 l' 13 DG 11K ... 3.2

.2 p 13 DG IDG !'IIACII 3.a. 

.3 p 13 lIN ... + l.2 

.. p 13 lIN + 3.2

­ - .5 P 13 ... JIIc:: 3.2 


86 p 13 De 11K IIIICIi 3.:11 


., p 13 lIN ... + 3.2 

P 13 lIN ... ftACII l.:II 

P 13 lIN ... IDCI 3.:1 


.0 l' 13 DG ... + 3.:1


~GULATORY~ORT - 335 
90 DAY INHAlATION TOXICIY STUDY IN THE RAT WITH RECOVERY PHASE 

_DIAL

--

:11 

S2 

33 

3t 

'53. 

37 

Ja 

" 

to 

GIOII'I'. t SlCI:I IIIIU 

sa WIlD 

110 

• 13 

• 13 

)( 13 

I! 13 

• 1S 

I! 13 

)( 13 

• 13 

• 13 

• 13 

DOSI r.rnu.. 

.........­ AIIC3 

IJOIIDL 

.oau.r. 

IIOaaL 

.OJIIIUU'. 

IIOIIIDL 

IIOaaL 

IIODIIIo 

IIOIIIDL 

IIOIIIDL 

IIOaaL 

APPENDIX 10 -INDIVIDUAL URINE CUNICAL CHEMISTRY 

1000 PPII 

RDJI UIIlJIII au. RlJIII Willi ftDK COLOUII vor.... 811 l1li GLO'COIII ./UIID

at 

Y 11.15 1.Ut 7.02 .. IllIG 

11.0 1."',2 III." .. JaM! 


Y 37.0 I.UO '.01 
 ... y 

Y S.O 1.1ll0 111.58 .. 11M 
 ­ y 
 12.S 1.UO IllIG I." .. Y 18•• 1.12" 7.21 IllIG JaM! 

Y 21.0 1.01' 7.73 ... IllIG 

Y IS.O 1.016 '.!l0 ... IIJIO

Y '15.0 1.011 7.n .. IllIG 


Y 11.5 l.ea. 7.17 .. IllIG 


RBGULATORY/REPORT - 336 

90 DAY INHAI.ATION TOXICfY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 10 -INDIVIDUAL URINE CLINICAL CHEMISTRY 

GIIIOIIQI • .. DOD L.vsL. 1000 PPII amI IIALIl 


"DIll: 
 OlD vannt oua 

_ou. 8D .... IIlI'l'Ca.S IILOOD noDDI ORO/CRIll

IIUIIUJt ., -.1./1 

31 13 ftI.II.CII IdS +i' 3.1 • 

3:& 13 ftI.II.CII ftACI: +. 3.:1 • 

33 13 D8 IdS .. 3.2 • 

34 13 ftI.II.CII DG .. 16.0 • 35 13 + .. ++ 3.2 • 36 I 13 ftI.II.CII .. + 3.:1 

37 13 'I'IWlII Dc: .. 3.:1 • 

31 I 13 IllIG IllIG .. 3.2 

:It 13 DG ... .. 3.2 • 40 13 .. .. + 3.:1 • 

~GULA70RYnuwORT - 337 
•• 

90 DAY INHAlAnONTOXIcrY STUDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 10 -INDIVIDUAL URINE CLiNCAL CHEMISTRY 

CIlOU.. I IJICIS LlIYIIL. 1000 PPI 

IU........ 
 _DIll 

Uvu:&- UIlID ftDIII UUIIII ftDIII UUIIII 

AJlDIUo lID. ... .urc:B c:or.oua VOLUIII .. .. GLlIC08II B/IlVIID 110 	 -.l 

-U r 13 .OIlWi , 20.' 1.011 I.SC ma; 

..

.. 

" 

n p 13 IIOI1Wi I 20.0 1.017 '.0' ao 


t3 r 13 IIOI1Wi -r 11 •• 1.0U I.*, ... IIIQ 


r 13 IIOIIWi -r S.' 1.03' 41.1' 
 .. .. 

.5 	 r 13 IIII..aL -r 2$.0 1.011 '.73 DC! .. 


r 13 IIO.cJIL -r SI.O 1.01:1 7.33
 •• 	 .. .. 

u IIOIIWi 1.031 

r 13 IIOIIWi 11 1••0 1.017 I," DIll 

., 	 r 11 t.O ,.,,, .. ..

.. 

•• 	 F 	 13 110_ -r ".5 1.033 '.3' .. ..

leo r 11 IIOIIWi I 12.5 1••a:a '.It .. .. 

'REGULATORYIREPORT - 338 
•• 

90 DAY INHA1ATION TOXICTY srUOY IN nIB RAT WITH RECOVERY PHASE 

APPENDIX 10· INDIVIDUAL URINE CLINICAL CHEMISTRY 

GI:OVJI. , 	 DQh L.....' 1000 ... sa. I'lIIIUoJI 

RUllI UlUIII UJtllIIi UIlDIII 

.utDQ.L sa IIlIDI: JCII'1'tmI:B HOOD JIIIO'IBJII uao/ga 

lit _1/1 ---.1 r 13 IllIG IllIG IllIG 3.2 

.2 P 13 IDCI DC! IU.CII 1.2 

13 r 13 Del 'l'ILICI: '.2 

.4 	 P 13 IllIG -

DC + 3.2 


P 13 IllIG IllIG IllIG '.2
 'Ii 

sa 	 p 1J IDCI 11M IllIG :1.2 

.7 ., 	 U 	 .. + 3.2 

., 	 13 -

Del ... IllIG •• 2 

., 	 ., 13 IllIG DC + 3.2 


100 p 13 IllIG DII 'l'DCIi 3.2 


IREGULATORY.'REPORT - 339 
90 DAY INHAlATION TOXICIY sruDY IN THE RAT WITH RECOVERY PHASE 

CIllOUl'I 15 

su• .u.. 

AII'lII&L ilia'. liliiii: ....... 110 

U III 17 

'2 III 17 

43 III 17 

'" III 17 

II 17 "II 

", • 17 '" • 17 

.... 17 • 

17 '" • 

50 17 • 


D08I LwaLl 

UPIAIIAIICS 

-
lIOaAL 

IIOJIIIU. 

IIOmIAL

-
IIOJIIIU. 

IIOIIIIIUo

-
 IIOI11GU. 

IIOIIIGL 

APPENDIX 10 -INDIVIDUAL URINE CUNICAL CHEMISTRY 


0 1IPI 

UJUR 

CDLOVR 

UllIa 

YOLUIIII 

111 

UllDlil 8& UIIIIIII 

pH 

UIIIIIII 

GliIHlClflll 

nllll .,_:or 

l' n.o l.taO T.33 dIG IllIG 

l' 15 •• 1.J2S 7.111 IllIG IllIG 

l' 12.0 1.t3;t 6.11 IllIG II'1II 

l' 25.0 l.nT 7.22 IllIG Be 

l' 

l' 

n.1I 

27.S 

1.1113 

1.1117 

7••11 

1.12 

IllIG 

IllIG 

IllIG

.. l' 15.5 1.02' 6.81 IllIG IllIG 

l' 

l' 

'I 

lO.O 

1".0 

10.5 

1.0. 

1.02. 

1.02. 

'.IIS 

'.n 

7.06 

IllIG 

IllIG

.. ... 

... 

... 

tRBOUlATORY/REPORT • 3.0 
90 DAY INHAlATION TOXICfY SI1IDY IN TIlE. RAT wmI lGCOVERY PHASE 

APPENDIX 10 -INDIVIDUAL URINE CUNICAL CHEMISTRY 

QIlOUP. 5 lI08II LJIVIII,. 0 PPII lID. 	IOILII 

VRIa 8Ia DIa Dna Uncu. an ..... D'IOEIS Br.ooD HODU no/_

.- .0 _111 

U II 17 IllIG .. + '.2

fa 	 I( 11 'II'IUI.aI lIS ++ 3.2

43 II 17 'II'IUI.aI .. ++ 3.1 


U II 17 .. 'I'ItACIr + 3.2


IS 	 II 11 l1li8 'I'IlACS + 3.2 


II 17 IllIG IIU :1.1
 " 	 .. 

• n 	 II 17 'II'IUI.aI 3.2 

.. 	 .. 

• I( 	 17 'II'IUI.aI ++ 3.2 

til 	 II 17 .. 11K +

... 	 '.2 

5. 	 II 17 'l'IUoII3 + 3.2 

~ULATORY~PORT - 341 
90 DAY INHALATION TOXICrY STIJDY IN THE RAT WITH REroVERY PHASE 

APPENDIX 10 • INDIVIDUAL URINE CUNICAL CHEMISTRY 

sa, 

GJlOII'. 

PaIIl.B 

S DOSB QVI:L. 0 ... __ »....- UllIn uu.. 01.. uaaa: UUJIII ..DIU. su 

- NICS COLClIDI. '9'OLIIR .. »II CIL'IICOID .:a1IIIIII 

IIUIIIldt 110 III 

101 r 11 .....,. 11 11.0 1.011 '.23 ..
 11M 

102 I' 11 IIOIID.L 11 11.5 1.023 6.U .. ... 183 I' 11 lIOIIWo 11 1 •• 1.0U •• 11 DIG 11M 

:11:1, r 11 lIOIIWo 11 10.0 1.021 '.n .. Be 

185 I' 1'7 IIOIIIIUo 1: l2.S 1.0U ..., .. ..

101 r 11 IIOIID.L 11 D.O 1.024) •.U .. 11M

107 I' 11 .,..... 1: U.S 1 ••25 ..., .... ..

101 r 11 ..,..... 11 D .• 1.OZI '.1' ... DC

U. I' 11 IIOIIIAL 1: U •• 1.02l "It 

... 

... .., 

110 r 11 IIOtIIIL 1: 7.S 1.0n ....s DC 

REGULATORY/REPORT . 342 
- -

90 DAY INHALATIONTOXICI'Y SI1JDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 10 .INDMDUAL URINE CUNCAL CHEMISTRY 

tiIIlOlII' • 5 DCa LJrIBL. 0 Pili 
 lID....... 


- UllDIIi OlD UIIDIIi VIlDS .unJaI. SJD[ IQI!'CEIS Jr.oGO ..O'rlll. 1lIIO/GIIII 110 _1/1 

--

101 F 17 ..6 IIIKI nw:II 3.1 

102 ., 17 .... lin .. 3.2 

103 11 D6 IIIKI ilia 3.2 

., 

p 

1040 17 D6 .. IllIG 3.2 

105 r 17 D6 .. 3.2 

10' P 11 ..S - .. 3.2 

107 ., 17 D8 - nw:II 3.2

101 r 17 .. ­ 01; 3.2 

109 r 11 .. ­ I'MoCII 3.2

110 r 17 - 01; 3.2 

mEGULATORynmpORT • 343 
90 DAY INHAlATION TOXlCl'Y STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 10 -INOIVI)UAL URINE CUNICAL CHEMISTRY 

GIClCJ» I 6 DOIII LlI'fBL. 1000 PJIl sa:. JIII.LII 

UHAlt- va1llll ua:unr vaUII vaIB val.. 1IRDB MDIAL .. n:a AJICIl Ctr.CIID 'IOto1llGl • JIll GliVCOllll .'_111 110 III 

--III I 17 IIOIDIUo I' '1'.1 1.141 '1'.05 .. I11III 

12 I 1'1' IIOIIDL I' II.' 1.la7 7.46 DC 11M 

U II 17 1IOu:u. I' U.S 1.'24 '1'.10 IQIQ IUIII 

54 II 17 IIOIIIDI. l' 7.!Ii 1.'41 7.14 I'M ... 55 II 17 JIOBU, l' 14.1 l.t21 7.31 .. ..

56 I! 17 IIOI1DL I' 12.1 1 ••:112 6.8. .. .. 

57 I 1'1' ~ l' 11•• 1,'32 6.67 .. .. sa II 17 IIOlIIIUo l' 10.0 1.t38 6.7' lIIIO .. tit II 17 IIOIIIDI. l' U.I 1.t31 7.n DC IUIII 

60 I 17 IIOIIIDI. l' U.S 1.tal 7.27 .. ... 

)2fREGUlATORYIREPORT • 344 
•• 

90 DAY INHALATION TOXICIY SI'UDY IN THE RAT WITH RECOVERY PHASE 


APPENDIX 10 • INDIVIDUAL URINE CLINICAL CHEMISTRY 

, CROUJI. DOIIIILnn. 1000 PPI 


sa. IUILI 


01.. ftDIJI 1I1IDIIJ UltID 

M'1K1I:I. sa IIDlt D~ IIILOOI) 'U.O'III• 801" ....... ., _111 

al II 17 + JIIIQ .+ S.I 

52 17 ftACIE IllIG ++ 3.2. • 53 17 !'IlACJ: ... ++ 3.a • 

540 n + JIIIQ .+ S.lI 


as 17 ftACil .- ++ :t.2
 • 

" II 17 'lU.C:I ... + 3.2

57 II 17 DACI D$ + 3.2 


n II 17 DACI IllIG ++ 3,2 


17 JIIIQ JIIIQ + :t.2
 " • 

.0 .. 17 ft&CII IIl&CII + 1.2 

~/REGULATORYIREPORT - 345 
90 DAY INHALATION TOXICfY STUDY IN TIlE RAT WITH RECOVE1lY PHASE 

APPENDIX 10 -INDIVIDUAL URINE CLINICAL CHEMISTRY 

GIIOVI'. , DOIII Lnm.. 100. p.,. 


au. J'IIIILIi 


VUIIII UJlDlK nlIIIi ftllQi VllEa nlIIIi ....IKA.L au .... ....ua - eDLOU.'I 9'Or._ IIIiI pH GLGCOa B/DliD

., w.l 

-111 r 17 IIOIIIUIL I 17.1 1.020 6.10 .DC 111& 

112 r 17 IIOIiIIAL I 13.0 I.OZO 6."1 IIZG ..

113 r 17 110..." I 20.t J.OU 6.53 ... .. P 17 lIOMU. J;' 12.5 1.020 6.U .nc 11M 


111 P 17 IIOIIIIIIL J: a.5 1.031 '.30 .DC .... 
 11" 

11' P 17 IIOIIIaL I 1.0 1.021 6.10 .DC 1118

117 ., 17 JrOIIDL I 1.1 1.031 1.31 
 .. ..

118 r 17 lIOMU. I 12.1 1••Z2 6.31 .nc 
 .. 

119 P 17 ....u. l' ,.. 1.030 6.t" ..

lZ0 F 17 JrOIIDL I 1.0 J.040 6.S' -IIIW ..

~GULATORY~PORT • 346 
90 DAY INHAIATION TOXlC1Y STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 10 -INDMDUAL URINE CLINICAL CHEMISTRY 

GROUI'. , DOB& LIIVJIL. 1001 PPI
 sa:. I'aIa£.II 


UIlJD UIllD UUU QD1I 

1II:Df.IIL ax BIll DII.'QIIIS Ir.ooo IPII:O'I'IIIlI 

IIUIIBD 110 _1/1laO'" 

111 r 17 ..8 lin IN ".2 

112 7 17 IIIIC IllIG DI 3.2 

113 p 17 .. 11K DC 3.2

116 r 11 DG DG DIG 31.2 


115 r 1T DG IllIG !JI&CII 31.2 


116 1'7 DC IllIG .. 3.2.
 " 117 r 17 ... JIBe 'I'IW3 3.2 

11. r 17 :no ... DC 3.2 

11" p 17 :no 

... 

.. 'I'IW3 3.2 

120 r 17 JaG 3.2 

~GULATORYnwPORT - 347 
~ II 

., I ~ I 

::: II I : 

+ I + I ~. 

... 

I , 

• 

I I 

i 'II ~ ! 

~ I 

i 

0 I 

II " • 

~ Ii 

~ 

& 

~ ." 

m ~ 

0 

Z §2

"<

-

S< -

! 0 

z 

• 

e 

~ e 

.C 

'I! 


c 

::II -

z 

m 

0 

I: z

-


~ 0 

:.:a: 

m 

-
 en 

.... 


~ 

il 

§ 


9 


~ -<-z 

~ 

~ 

~ 

~ ~ 

~ trJ 
90 DAY INHAlATION TOXIcrY STUDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 10 -INDIVIDUAL URINE CUNCAL CHEMISTRY 

..... 1 !lila £DSI.. II pp. 


SID:. 1"IiI&LB 


u .... CUB'I'AL CUH JIIID aD ..nil • a'BSK ..DIAL Ult DB cu.u CIILL. c:&L8 _1m 110 

61 r 13 D(I IIIIGI DG .. IIIGI IIIIGI

U r 13 IIIIGI IIIIGI ... IllIG IIIGI ... 

'REGULATORY/REPORT - 349 

90 DAY lNHALATJOlS TOXlCIY S'J'UD'Y IN THE RAT WITH RECOVERY PHASE ... ~ 

APPENDJX 11 • INDIVIDUAL ORGAN WEIGHTS (9) 

Key: 


following comments may appear in tbis Appendix. 


NO 

WT 

w 

~ 

number 

weigbt 

EPIDIMS 

'PrruIRY 

. epididymis 

- pituitary 

WRR ­

LUND ­

right adrenal 

lung both 

TESL ~ testis left UT/CERV ~ uterus with cervix UT/CV­ uterus with cervix 

COMMENTS 

Number 31 - TESL reduced by 50% ,'. 

Number 79 - LUNB inflated prioir to weighing (excluded from statistical analysis) 

Numbet 86 • UTCV distended 

Number 46 - ADRR abnormal 

NwnbeJ 110 - mOHr ADRENAL GLAND redu<:ed 

Nwnbel33 - PITIJrrARY damaged at necropsy (excluded from statistical analysis) 

JREOULATORY/REPORT # 350
90 DAY INHALATION TOXICI'Y S1UDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 11 • INDIVIDUAL ORGAN WEIGHTS (g) 

aoaJI. 01 

PIGL

... DOIIII r.JIQL. 

lIOII'lQI5In! 

(g) 

0 ppa 

AIIU:IW. II:lMK'I' 1ft' BOn 1ft' 110ft 

LIYD _I.,. UnIS 

1ft' BOn: 

SlDh 

UDja 

1ft' 80ft 

........ 

IIIAJ. a:a'f 

_I' 

DZen 

1 =60.0 0.065 3.$1$ If.587 :r.5" 1.301 2.121 1.6" 

a ....0 0.0l1li 3.012 lI.1Z7 3.727 1.431 a.Dl 1.253 

3 .".0 0.071 3.146 11.713 3.637 1.367 2.130 1.367 

4 C71.0 0.062 3.0e, 11.'19 3.3152 1.271 2.0&' 1.313 

5 U2.0 0.065 3.3U 17.2'" 3.'91 1.511 2.111 1.tl5 

, U6.0 0.072 3.212 11.017 3."0 1.231 2.CDO 1.667 

'7 !17.0 0.0'3 3.ltt 1I.1n 3.69' 1.492 2.Ul 1.445 

I ~2'.0 0.0'11. 3.316 11.023 4.2<12 1.547 2.873 1.507 

, $23.0 0.060 3.4c6 17.161 3.715 1.385 2.lI86 1.5S. 

10 505.0 0.0" 3.05' 17.211 3.61' 1.2157 2.014 1.'0' 

IlEGULATORY/REPORT - 351 
90 DAY INHALATION TOXICTY STUDY IN THE RAT WITH RECOVERY PHASE 


APPENDIX 11 .. INDMDUAL ORGAN WEIGHTS (g) 

~. 01 DOIIII UVIIL. • ... BU. IWoI' 

anmr. 

110. 

1IOO!DIGilft 

(II) 

5 ••0 

SPUD 

dtG8'f 

1.027 

ft'IIIIII 

al"

...., 

ftDIOlD 

W'1' lIO'I'II 

O.Il:U 

'J'.I'fI/U

OIGld 

'.110 

l.VW rt'I 

IIOIB 

I.'" 

f ••O 1.05• '.430 0.G2' '.01.0 1..71" 

I ••• 0 1.Ul O.t.1 o.au •• 000 1.75' 

, tn.o 0 • ..,' 0.310 0.019 ••011 1.916 

112 •• 0.153 0.'05 o.a:u '.012 1.611 

, •••D O.'fO 0.41'. o.au '.011 2.212 

f 511•• 0.'" 0.3411 O.OLa t.OJ.O 1.7'5 

• 5211.0 1.3.3 O.U. 0.02' 0.009 2.091 

, 5:U.0 1.0n 0.03 0.022 0.011 2 ••" 

U 105.0 ••"0 0.a111 ••C:12 '.01. 2.212 

:/REGULATORY/REPORT - 352 
90 DAY INHAlATION TOXICI'Y sroDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 11 - INDIVIDUAL ORGAN WEIGHTS (g) 

GI.'OVF. 02 DOB LIIY.I'L. 100 W- IDJI:, JDH 

UIMM. IIODTISIGIII' .&IIiUIDL lillIlID' LDD ftftIS DID/. IIIUoDI -!! .-0. (t) .., JIOIIB 117 110ft UllIIft' .. JIOIIB 117 1lOIII UIaY QICIIft 

11 101.0 0.012 3.nO 17.433 3.171 1.3" 2.013 1 ••0. 

12 "~.O 0.072 2 ••1. 17.2&2 3.61" 1.220 2.061 I.JlO 

13 "".0 0.0'" 3.13' 11.... 3 • .,1 1.377 2 ••83 1.113 

14 131•• 0 ••15 3."31 It••• 3.13. 1.170 1.302 1.621 

15 UZ•• 2.177 11."" 3.011 1.atl 1.tl' 1.261 0 ••" 

16 .U.O ••018 2 ••33 11."0 3.7'" 1.317 2.114 1.:13. 

l' 527.0 0.073 3 ••0' It••7 s.". l.n. 2.U. 1.71t

U IU.O 0.011 3.367 17 ..... 3.170 1.ln 1.116 1. Ita 

11 ....0 0.01S 3.011 17.1121 ,..... 1.U' 1.181 1.J.0

2. tI,.o 0.01. 2 .... 11.11' '.t.t :a~01t 1.134 1 ••" 

JRBGULATORY~ORT • 353 
90 DAY INHALATIONTOXICTY STUDY IN nIB RAT wrm RECOVERY PHASE 

APPENDIX 11 • INDIVIDUAL ORGAN WEIGHTS (9) 

CIlOUJ' ••2 DOA YYU.I 100 ppa sa. DLII 

lIIIIDL 

1m. 

IIOIII1IItXQU [., III'UIIII 

RIG1ft' 

'I'ftIIIIB 

RIC1lIII' 

'mQIIID 

.... IIO'IK 

PIn/a 

RIGII'I' 

r..e .... JIOII'II 

11 IUI.O o.'n. ' ••01 '.011 0.00' 1.7" 

12 401'.0 0.'70 0 ••" o.oao 0.'10 1.60' 

13 ••••0 ••••a 0.41' 0.011 0.00' 1.'16 

1. "a.o 0.91' O••U 0.023 0.011 1.'63 

15 tllI.O 0."5 0.377 0.017 1.'11 1."" 

l' "'''.0 '.1110 0.3'" 0.01'7 '.010 1.MI 

17 !In.o 0.801 0 ••• 0.oa5 0.0" a ••" 

11 •••0 0.1" 0.50'7 o.oal 0.'12 1."0 

10 .'.0 1.0aa 0.614 0.022 0.00' a.n. 

10 463.0 0.1.16 O.tH 0.017 0.00' 1.61' 

!/REGULATORY/lt.EPORT - 354 
90 DAY INHAlATION TOXIcrY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 11 • INDIVIDUAL ORGAN WEIGHTS (g) 

SIIOOl'. 03 DOIIII r.JI9U,. 300 ps- ax• ..... AImIu. BOIlJDllm'r ADIIIIIUIo JtIDBI1: IUD RII'IIB DID!_ BDDI 110. <., 1'1' IlOl'8' 1'1' JM)'IW 1rIIr.... .,. 110ft 1'1' 1lOIII _:min' IllUfID 
 ...." 

U .'7.0 0.051 3.2. 20.032 3.161 1.1112 2.1J1 I.S17 


U '29.0 0.0'71 3.141 1'7, '733 3.902 1.2'IS 2.16' 1.111 


U !lli1.0 0.064 3.7A 21.'05 3.12" 1.35' 2 ••''7 1.11' 


'" "'1•• 0.0156 3.0" 15."1 3.2" 1.511 2.04S 1.321 


111 !!:l0.0 0.010 1.91. 16,017 S."" 1.t.O 2.301 1.491 


16 !llit.O 0.067 3.765 21.061 3.1&' 1.3'IS 2.014 1.'11 


n .'.0 0.07' S.3Zl 21.375 3.'5.9 1.4U 2.U. 1.702 


.. !IOO.O o.on 3.322 1••ISI 3.91' 1.3'1 2.160 1."1 

29 Q4.0 0.056 3."7 19.125 3.6"" 1.4" 2.1':11 1.114 

10 .....0 o.Ollt 1.76) 11.110 3.112 1.213 2."5 I ••" 

~GULATORY~PORT - 355 
90 DAY INHAlATION TOXICfY snJDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 11 - INDMDUAL ORGAN WEIGHTS (g) 

~. os D08I: wrv.L. 300 ppa sa. ur.a 

.... nw. 

110. 

BOPnII1811!' 

(,) 

Ur.III:II urClft ~ 

"1GB'l' 

DnlOID 

11'1' 1lOIII 

lPr'I'IJ/llI' 

1111... IolJllll 1'l' JIO'I'II 

:U 1".0 1.005 0.'.7 0.01' G.OI0 2.032 

:12 Sat. 0 1.0lt O.U' 0.022 C.011 2.001 

23 SSI.O 1.031 0.'13 0.0121 C.OO' 1.1'1' 

24 "l.O 0.'11 0.'" D.CIlO 1).007 1."7 

25 III•• O.87S O.U" 0.8'.16 c.on 1.'15 

26 alt.O 1.147 0.'0' o.lI1a . 4).014 1.'01 

2' 5".0 1.0n 0.'61 o.lIn G.Oll 1.114 

21 5l1li.0 O.US 0.,1t 0 • .Q11 '.Oal 2.0" 

21 IX.O· o.,n 0.15' 0.e2' ••011 1.,.11 

S. ' ••0 0.'" 0."'· 0.G21 '.00' 2.liS 

~GULATORynuwORT • 3.56 
•• 

90 DAY INHAlATION TOXlCfY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 11 .. INDIVIDUAL ORGAN WEIGHTS (g) 

GIOVI'. 04 II08Ir LImIIi! 11'00 JIPI 	 -.:. l1l£I: 

AIID1r. 8OO'IWI'r... ADiUltU JtIIInJ' LIYD I'JIBI'rs DUI,_ IIIIUII aaJl'I (g) 	 11'1' BOft 11'1'_ nUlll'.l' 11'1' JIOItII DX.... _I.... " 1lO'III 

:U 5••0 0.057 I.U. ,S.U'S l ••a. ...,.. Z.O'" 1.150 

.n ..56.0 0.072 3.3" 17.1•• 1••01 1.310 2.026 1.531 

31 5N.0 0.063 3.41:1 11.366 I ••n 1.187 2.152 1.461 

U "117.0 0.066 3.2." 16 .151 '.4.' 1.211 2.11.1 1.4sa 

U .Ila.O 0.072 3.S17 1'.121 '.4.5 1.3'76 a.12' 1.4n 

:u 530.0 0.0'1 3.S46 1'."0 ' ...01 1.503 2.221 1.552 

3' 5».0 0.011 3.02:1 11."0 1.114 1.365 2.0U 1.501 

St ..a .• •••.0 3.0U 111,UO J.1.5 1.:'" 2.1" 1.254 

3t "".0 0.063 3.0!12 1.,.lilt ... 7'10 1.flO a ••'3 1.451 

u 4•• 0 0.06. a.'4' 14.S" 1.112 1.4n a.16. 1 .... 

~GULA10RYnrnPORT - 357 
90 DAY INHALATION TOXIcrY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 11 -INDIVIDUAL ORGAN WEIGHTS (9) 

IIIIOVP. 04. DOSII 1'dIYIII.. 1000 PPII SUI IIILJI 

.ur:rJIAL 

E. 

JIOI):msI..... 

(9') 

..UD or&'l' 01

-... 

DDIOID .... IICWII rJ'fUfm' DI..... LUIIIQ WI 

IIO!IIl 

U Sll'.O 1.004 0.37' 0.0" 0.00' 2.10'1' 

12 4".0 0.'17 0.U4 0.024 0.00' 1.16' 

13 !lI4.0 0.'" 0.433 0.0:ita 0.004 1.'75 

;u ".'7.0 1.015 0.311 o.O:Ie 0.011 1.'774 

3. n ••o 0 ••6. 0.41:1 0.017 0.010 1 ••341 

16 

37 

~30.0 

526.0 

0.'01 

o.n. 

0.114 

••I!! 

•• 0:1"

..... D.OIO 

O.Oit 

1.'711 

1.10 

I. 'Ia•• G.'32 0.111 •••26 0.010 1.'23 

It •••• 0 0.'71 0.420 0.011 0.00' 1.142 

40 455.0 G.I" O.I~I •• D17 0.005 1.1'7 

fREGULATORY/l.EPORT - 358 
90 DAY INHALATION TOXICI'Y S11JDY IN nmRAT \lITH RECOVERY PHASE 

APPENDIX 11 -INDIVlDUAL ORGAN WEIGHTS (9) 

caovr. 0' DOBII: urvu.. 0 ,.. SUI IQU

_:ow. BOO.....IGII'l AIIIIJIDL 111_ LI.... ru'lI8 ..ID'.... lIJI&la ........
 ... (t) 11'1' eon: rr BO:rI _I~ 

., JNI!'Jr .... BOllI axcan UlGll'l 


u au.o 0.011' a.'Ol 1..... 3.405 1.U3 2.070 1."1 


'2 ta•• o o .on 2•••• n •• a" 3.730 1.:14,' 2.011' 1.1110 


U 11'.0 0.0111 3.20' 1'.211 ...., 1.1:12 2.1113 1.'57


U "0.0 0.073 •• 2110 1'.1:1' •• 074 1.1611 2.111 1."" 

U all•• 0 O.Otl ••112 17.71. 3."1 1.""1 2.172 1.SH 

" '''''.0 0.0" 3.111 17.11' "'.2~O 1.31' 2.1•• 1.S14 

47 a.... 0.071 3.13' .I••", 3.,01 I.S1'1 2.1n 1."1 

n 511•• 0 ..." 3.396 n.la 3.I7S 1.512 2.114. 1.", 

... lIIt3.0 0.'" 3.0'" 11.'" J.'" 1.'" 2.'11 1.UO 

110 1122.0 O.OH 2.''4 17.14" 3.IU 1.2112 2.,12 1.... 

VREGUlATORY/RBPORT - 359 
90 DAY INHAI....\110N 1OXlCl'Y STUDY IN THE KAT wrrH RECOVERY PHASE 

APPENDIX 11 • INDIVIDUAL ORGAN WEIGHTS (9) 

GIOUP. O. DCA UVJ:I.. D PIlla 810:, DIoI 

rMIIG _ 

PDfAI, 

.o. 

BOIDYlll:IGII.'I'.' 

(II' 

BJ'LJIa 

DZ..., 

ftDIU5 

"1I11II'I' 

'I'IQIlOW 

lit' B(IftI 

.Ift/In

BIGU '10ft 

U 

n 

1511.0 

..... 0 

0 ••'" 

.1.074 

'.:1" 

0.4" 

o.ou 

o.ou 

••0" 

'.'05 

1."0 

1 ••4. 

4., list.0 t ••a. 0.:117 O••J. O.HII 2.011 

4. !l'0.0 1.017 0.65' O••UI 0.011 1.'2. n !1M. 0 1.073 0.310 0.01' 0 •••• 1.71111 

41i 

.7 

!I".• a.... 

•. au 

1.oall 

0.'" 

..... ••016 

0.016 

0.0" 

••0011 

1.,..' 

2.1'2 

.... 

4. 

5114•• 

5U.0 

1.140 

1.217 

o.:lU 

0.311 

•• 02. 

•• O~O 

•••11

..... 1.731 

a ••05 

ao 1122.0 0.11111 0.4.11 0 ••2' •.0.7 1.'73 

:,tREGULATORY/RBPORT - 360 
•• 

90 DAY INHALATION TOXIcrY SnJDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 11 • INDIVIDUAL ORGAN WEIGHTS (g) 

GIItIUIr. 0' 001II: r.JI¥BIo. 1000 ,.. lIB. IIIir.& 

AllDII.Io ~IGIl'! ADIIDUd. Itl_ _I...,
 r.I't'D 1'II81'l:& DID,.. UtADI IIIU'I' MI. III' IIO'fB tn' JM)Ift Irt IIO'fB tn' IIO'fB Dlem'l' urGe '.l 

11 521.0 0.077 3.3n 11.... 3.31111 1."" :I.U' l.al 

52 141.0 0.05' 3.'" U.I'" 3.... 1.330 2.U5 1 ....' 

53 IIC.O o.on 3.311 llt••n 3 ••3. 1.111 :1.0" 1."" 

5" 1147.0 0.075 3.110 17.'" ..142 1.702 :II .:11:1 1.~83 

57t.O o.on 3.315 11.412 3.'5' 1.IIU 2.100 lS'6 

56 1117,0 0.010 3."" 11.11' 3.'01 1.41" 2.115 1.'" 

II? 561.0 0.'62 3.061 u.nl 3.116 a.2011 1.31117 1 • ...,. 

sa Sl4.0 0.0740 3.7401 17."4 3.IU I ••" 2.143 1 ••U

5. 503.0 1.063 3.10:1 11.120 3 ••5. 1.UI a.15' 1.3'S 

" 'IIt.O 0.056 2.122 It.ln 3.'" 1.41. 2.051 1.412 

flrnOULA10RY~ORT • 361 
90 DAY lNHALATION TOXICfY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 11 • INDIVIDUAL ORGAN WEIGHTS (9) 

6UU:t... DOSII: s.na.. 1000 p.- BIll. DLI 

MIIGIL 

lIO. 

BOD11I'IIGIl'f 

(IJI 

....... "I81ft' DIGIII!' 

-­ 'ftInODI 

ft_ 

11'ItI/lI'I' 

.Xlllft' 

t.UIIII PJIO'III 

III II:aI.O l.llS 0.31. '.011 0.005 1.173 

52 5.... 0 t.tO. 0.335 0.02' 0.006 1.110 

531 1110,0 t.0'5 0.S'4 0.021 0.005 1 ••" 

5. 54'7.0 l.Oll 0.441 0.020 o.ooa 1••'1 

55 lI7'.O 1.1'" 0.413 0.021 0.00. 2.005 

U .517.0 •• "3 0.463 0.021 0 .... 1.'07 

57 561,0 ...., 0.392 0.025 O.UOI 1.7311 

.1II. 56•.0 

lIO'.O 

1.173 

1.013 

0.421 

0 ..... 

0 ••21 

0 ••2' 

0.'05 

0.011 

2.10. 

1.IS' 

ao 45••0 ..115 0.'.&0 0.01* o.ooa 1.101 

~ULATORY~RT - 362 
90 DAY INHALATION roXICfY STUDY IN THERAT WJI'H REffiVERY PHASE 

APPENDIX 11 - INDIVIDUAL ORGAN WEIGHTS (9) 

GIIOUI'. 01 IXIII:S r.:I'9&. 0 JllII Ba. I'IIIDLII 

DDI.U lIOI)'IIIIIIG1ft ADIIIDIAL Ill...., 1oI'9D OY.UI'I IIUIJI IIDIII 

,;, 

110. (I) H' IIOftI 11'1' DOI'II ..taft WI IIO'I!. Rl111n RlGln' 


11 333.0 0.013 2.U7 12.611 0.102 2.0'0 1.030 


n 312.0 0.011 2.3t! 13.2112 0.1'0 2.03111 1.250 


2".0 0.011 2.070 10.1'71 0.117 1 ••n 0.'32 


It 3U.0 D.on 2.U7 10.100 O.Ollt 1.170 1.016 


" 21'1.0 0.01t 1 • .,5 ,... 
 0.103 2.0t. 0.lt03

" 316.0 0.011 l.nl l1.tl1 0.1111 1.n7 1.2131 

17 322.0 0.011 l.no 11.'" 0.115 2.030 1.011 I. 329.0 0.0'0 2.173 11.1" 0.117 2.027 1 • .,5 


,to ·211.0 0.0" 1 .... ••7. 0.101 1.". 1.010 


7. 301.0 0.015 I.'" '.3'7 0.11' 1 .... 1.012 

/REGUlATORY/REPORT • 363 
• • • • 

l: 

~ a 


~ 

~ ~ "i 

~ 

J .. .. .. .. .. .. .. .. . 

IE ... 0 .. .. .... .. .... lot N .. ~ 

0 

• 

11; •

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lit 

III

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.. .. ..
 .. ..

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 .. •.. .. .. .. = ..

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0 lit ..• ... .. .. :: .. ::: II 
 0 0 Q 0 0 0 0

.. W ;.. lit ;., .. ... 0-

w 0 .. 0 .. N 0 .. .. .. ~ 

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w ... .... II III • 

0 0 co .. • • !" !II' '! . :I; 

0:0 0 0 

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III III lit 

.. 
 !'" .... ... .. w 

• 

.. ... .. :- !'" j., :.. ., ... II' 

... .. N 

... 

0 :: .. .. 0:0 0:0 .. .. II 

, 

11;1 

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.. ... .... ... ... ... .. .. 

• .... .. '" ... .. ..'" 

... ... .. • .. .. 

.. ... .. ·.. ;,. 

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lot !I 

,

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 z 

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..... z­a

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 S 

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 0

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---

• ••• 

90 DAY INHALATION TOXlCfY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 11 -INDIVIDUAL ORGAN WEIGHTS (g) 

GROal'. oa DOIII U'fD.. 100 pr.- IU. rau& 

AlfIDL BODrmlIGIft MJlIIIIW. .IJIIIIIY UVD 0VPr ....u 110. Clr) W"I IIOftI W"I 10IIII a'GIft W"I 1lO'I'II aran ar.,. 

71 3:U.0 o.on 2.3" 11.084 0.112 1.127 1.0» 


72 327 •• 0.117 :a.oo. 12.UI 0.077 1.166 0 • .,6 


73 :Z.I.O 0.01' 2.011 10.13. 0.0'. 1.133 1.014. 

7. 311•• 0.0" 1.r-n 10.2011 0.111 1 ••'3 o••a 


71 216.0 0.0'7' 1.121 1.10. 0.120 1.n, 
 0 ••" 

,. 322.0 0.017 :J.2n 11••23 ••107 2.01. 0.K1 

77 211.0 0.010 1.711 10.666 0.111 1.'0. 

71 31:1.0 O.oa. 2.151 11.6" 0.011 1 ••12 1 ••" 

7. 302.0 0.0" 2•••• 10.6t3 0.137 1.'U 1.ln 

II 303.0 0.016 :a.on 10.111 0.111 a.l01 1.039 

l . 

lREGULATORY/REPORT • 365 
90 DAY INHALATION TOXICrY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 11 - INDIVIDUAL ORGAN WEIGHTS (g) 

~102 DOSB IoJIYIIL I 100 lis-	 BU. DIIIIIoIi 

UIIIAL BODYRIGII'I V'!I/CD.V SP..... ~ mDIOID tI'I'D/1'!' r.UIII WI' 

110. 	 (5) HIGIlt' DJGII'I' nI~ .,. 80ft Ul.... BO'I'II 


71 321.0 0.701 D.7U D.'" 0.011 0.011 1.170 


72 327.0 0 • .,5 O.UI 0.017 0.011 1.3"
 0 ••" 


731 2".0 0.7117 O.ltO 0.022 0.012 1.311
 0 ••" 

7. Ul.O 0 ••21 0.'11 0.3" 0.015 O.OlS 1.3" 


711 21'.0 0.732 0.721 0.3n 0.017 O.OU 1.'" 


7' 32~.0 0.614 O.U' 0 ••62 0.011 0.014 1.11211 


77 211.0 0 •••2 0.U2 0.311 0.022 0.012 1.2U 


71 313.0 D.IU 0.110 0.417 o.DU 0.016 1.'71 


71 302.0 0.761 0.172 0.356 0.02' 0.016 3.Sn 


10 303.0 0.500 0.7211 0.3" O.DU 0.013 1.8111 


~GULATORY~ORT - 366 
•• 

90 DAY INHALATION TOXICIY STIJDY IN THE RAT WITH RECOVERY PHASE 


APPENDIX 11 • INDIVIDUAL ORGAN WEIGHTS (9) 

GJIOI8P, 03 DOSII LBVI:L. 300 PIlI 	 ID, ........
 _1_ -­ AIIIDL IIDDIRIGIl'J' AmUIUL I:JIIEIT LIVU O¥U'I' BRAD IIDft 

110. 	 €I,) ftllOB ft Hft .I8!'l' 'ft 110ft 


U 305.0 0.0" 1.121 11.121 0.15' 1.GlO
 1 ••" 


.2 311.0 0.100 2.01' 12.16' 0.114 2.012 1.05. 


.3 301.0 0.079 :II.IlS6 11.556 0.103 2.02. 0.116 


303.0 0.0'1 1.15' O.lIT 1."5 1.121 II••" 

.1 2455.0 •.•,1 1.113 '.611 0 •••• 1.U' 0."0

326.0 O.Ottl 1.,., :II.~2' It.'20 0.111 1.lO3

., 

" U3.0 0.012 1.121 t.'11 O.OtT 1.115 0."" 


II 302.0 0.01' :a .()J:II 11.040 0.1.' 1.136 1.123 


It 30'.0 O.OI! 2.1l" 10.'12 0.0" 2.11' ••IU 


O. 214.' o.•n :II.IlO' t.U!! 0.'" 1.'" ....!! 

REGULATORY/REPORT - ?fJ7 
90 DAY INHALATION rOXICIY STUDY IN THE RAT W1'UI RECOVERY PHASE 

APPENDIX 11 • INDIVIDUAL ORGAN WEIGHTS (g) 

GIiI:IIn ••• 0Q8I. t.&V&L. '01) ppa MI., J"JaIN.II 

JI1IDN, JIOPl'IIISCII't lIf/CUI ........ 1IIIJIOtD l'l'IU/D' ....... 
 110. (g) ..1.... al'" DI-
... wrJlOlll B'GII!' 

11 lit•• 0 0.5P3 0.7l<! 0.432 ••017 ".010 -

1.6:14 

1:1. 3U•• ..511. 0 ...... 11.124 •• 02:1 O.olS 1.423 


.3 3•••• o.a•• 0.". ••33' ..8:13 0.010 1.411 


., lin•• 0.503 ••7'" D.a'" '.812 ••00' 1.":1: 


.11 :"11.0 •. '9' 0.733 0.'.0 ••810 0.00' 1.452 


.6 326.0 1.22. 0.7" 0."•• ••014 0.020 1.'Ill


17 :113.0 •• 536 0.". O.4t7 ' ••2.6 '.011) 1.4" 

II .w2.0 0.717 •• '3e 0.417 (/.017 o.OU I.Ut 

19 ....3 0.711 0.410 ••OZ' 0.022 1.a66 

to 214.0 O.18Z 0.6.1 O.J.' t.014 0.0111 1.754 

" •• 0 

:/RBGULATORYIREPORT - 368 

90 DAY INHALATION TOXICTY sruDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 11 - INDIVIDUAL ORGAN WEIGHTS (9) 


GIIOVP. o. DOSJI ~. 1000 :p.­ sa. J'mIII.I:S 

AIIDIIL 

ItO. 

IIODJ'DJQft 

(I) 

.I.DIlIIII.IL 

'" IIO'InI 

IEIJlD1' .., 110ft LIYU 

nIGIIl'l! 

!WAllY ft_ II1I&.I. 

nJGll'l! D&Ilf n:llillD' 

U 309 •• •• 011 2.0n '.6n. 0.10:! 1.17:1 1.lt• 

.~ 32'.• •. on 2.0U 10.3M 0.113 1.'" 1.U• 

t.! 3U.0 0.091 2.1112 ' .•J. 0.111 I ..... O.tll 

I.. 2U.0 •• G,O 1.713 '.U2 0••" 1.112 0 ••01 

II 2ct.0 0.061 1.41' 7.1" •• 0,. 1 ••61 0 ••0. 

•• 

t7 

3U.0 

309.0 

••0.' 

0 •••• 

2.012 

2 ••31 

11.1" 

1••2'. 

0.131 

..u, 

1.ttl 

1.92' 

1.as" 

1.101 

II

., 30&,. 

27-1 •• 

0 ••" 

••07' 

1.'" 

1."2 

11.3" 

•• 715 

•• 133 

0.112 

1.ttl 

1."7 

1.00. 

0.12' 

lOt 2'7.0 0.0'. 1.'31 '.41.1 0.113 1.'16 0.'114 

/REGUlATORY/REPORT - 369 
90 DAY INHALATION TOXICI'Y STUDY IN THE RAT WITH RECOVERY PHASE 


APPENDIX 11 .. INDIVIDUAL ORGAN WEIGHTS (g) 

GIIOUI'. o. DOIm I'&9JIL I leoo PPI lID. nIU.:I 

UDIlIL aovzn:IQft n/cav SJr.aII 'fIIJ.'JlO11 fI!'II"Jrf r._ WI' 

10. (II' nlGft UI... UIR'! -
 1ft' BOn U:I8Ift' 80ft 

,. 

91 30••' 0.732 ••121 0.t20 0.016 0.011 1.:1:12 


12 326.0 0.766 0.7D' o.e" 0.011 0.'17 I ••• 


n 311.0 0.n7 o.no o••u 0.01lt O.ote 1.621 


2".0 1.2<117 o.n. O • .IU 0.011 O.OU 1.1. 


:UI.O O.Ul 0.613 o.Ut 0.01' 0.011 1.2" 


.. 

" 

'11 32•• 0 0.550 0.716 0 .... 0.01lt O.OU 1.619 


97 30'.0 0.701 o. no 0.503 0.012 o.oUo 
 1 ••'" 

301.0 0 • .01 0.011 I.OU 1.D. 0 ••" 0 ••" 

.. 270.0 0.13' 0.1175 0 ••11 0.01lt ••OU 1.330 


100 217.0 o••n 0.653 0.335 0.013 0.012 1.3ea 


IREGULATORY/REPORT • 37() 
90 DAY INHALATION TOXIcrY STUDY IN THE RATwrnI RECOVERY PHASE 

APPENDIX 11 • INDMDUAL ORGAN WEIGHTS (9) 

~. 115 DCa ....,... 0 ppa 	 ID, I'IIIIIUioII 

AIIDWO _BIllGIn' JiIIIIIIIIaL Itla.D' LX.... ovan: BU.DI IIIUl'l' 11). (gl .., :eon .., JOn _IGIl!' '1'1 BOI'II _lOR 1IIIIIBr 


LOI ua.o 0.0'7 2.LLO la.!lU 0.U6 2.063 1.U' 


102 306.0 o.on 2.0.... 10.41' 0.117 1.117 0.110 


103 302.0 0.018 a.2ll ••au 0.U3 1.ta7 1.1Oa 


10~ an.o 0.064 1.,." 0.0'2 1 .... 0.'1' 


105 217.0 0.0740 1.ttO 1.800 O.lal 2.0as 0."4 


lOt 323.0 0.0" 2.251 11.320 0.130 2.0U 1.172 


l07 353.0 0.074 2.na 13.631 0.111 1.'35 1.140' 


101 307.0 0.071 2.017 10.aal 0.117 1.175 O.PI' 


I ••'" 

10. 	 UI.O 0.01Z a.l11 U.7'0 0.082 1.1" 1.,"' 


2.02' 110 ZI5.0 0.057 	 ' ••77 0.0111 1.tl6 0.'l3


IREGUlATORY/REPORT - 371 
90 DAY INHALAnON TOXICfY STUDY IN 'DIE RATWrm RECOVERY PHASE 

APPENDIX 11 - INDMDUAL ORGAN WEIGHTS (9) 

folIIOU1'. 01 IlOSIi UUL, 0 ". 	 BU, nar.B 

UIDIIoL BODDUliIII'I 	 "',a.rI ....... 
 IImIUS IIIftOID .Ion'.... LUII8 .... 110. 	 (.) ar.., ..I.., WlI.., .... 1lOIII aleaft' 1lOIII 


101 342.0 o••n o.,211 C.'" 0.01' •••04 1.U2 


102 306.0 0."0 0.701 G.2" 0.022 0.110 1.115 


103 302.0 G.'" 0 • .". G.431 0.01. 0.011 1.,"' 


104 2'2.0 0.'30 0.11120 G.3" •• 011 0 .... 1.1" 


105 217 •• 0.1" G.711 0.42' 0.014 0.012 1.SU 


10. 323.0 0.'12 0.71' ....2 0.01' 0.013 1.$1' 


107 313.0 0.71110 0.'" 0.42' 0.011 0.014 1.1" 


10e 307.0 0.1113 0.4010 0.017 0.014 1.314 


10' S15.0 1.IlS 0.710 0.361 0.01' 0.014 1.'$1 


110 211.0 0.4" ..,., 0.314 ••013 0.014 1.271 


0 ••' 

'RBOULATORY/REPORT - 372 
90 DAY INHAlATION TOXICfY STUDY IN TIm RAT WITH RECOVERY PHASE 

APPENDIX 11 • INDIVIDUAL ORGAN WEIGHTS (g) 

GIIOUl'.OI D08I L...... 1.000 PJIIl 	 SU, rau.. UDaL ..,..., IOO'fUIGB'I lWIIDUo lUlImI'f r.J;YD OVAII:r MAD 110. 	 (II) ft' 110ft ft'_ DJGIft ft' 1lO'I'II DleII! DllIft 


111 SU.O 0.07. 1.''1. 10.'.3 O.U' 1.'77 1.0&7 


112 ltO.O 0.013 2..0'12 10.23. 0.014 1.123 0.'" 


liS 1".0 0.074 1.'11 10.061 0.0" l.tl2 0.tl3 


11~ '00.0 0.01t 2.0" t.U" 0.117 I.US l.t13 


l15 at5.0 0.013 2.010 t.170 0.177 a.03' I.'U 


1:1.6 HO.O 0.012 2.272 10.213 1.117 2.0:z.t O.,U 


117 112.0 0.1" 2.23'11 11.12t 1.112 1.'" 1.1'2 


11. I1t.O 0.07. 2.17. 10·00 I.OIt 1 ••Tt J..OlO 

11. '1'.0 0.0111 2.03. 18.750 1.112 2.03' 0.tl5 

.20 111.0 o.OTt 1."0 '.332 O.US 2.013 0."7 

IREGUlATORY/REPORT - 373 
90 DAY INHALATION TOXICTY STIJDY IN THE RAT WITH RECOVERY PHASE 


APPENDIX 11 • INDIVIDUAL ORGAN WEIGHTS fa) 

GIIOD. O. DOD Llr9U.. 10.0 ... mu:• ...... MDW'. IIOIImIIIIIII'I' VI/CUY Dr..:. I'KDIDII t'InIIOlD un/u r..- 1ft' 110. 	 (.) DIG1ft' Wl:GU DIGiII'l' 1ft' lIOII. 81l1l'i' BO'lIII 


111 3at•• •• tl7 •• 110 0.3" •••11 0.016 1.at' 


112 290.0 0.111 0.621 0.1311 0 ••11 0 ••l1 1.317 


113 211.0 0.1" 0."" 0.372 •••14 0 ••13 1.522 


11.. 300.0 0.13' G.13I2 0.375 ..017 0.01" 1.2" 


111> 215.11 0.5'" '.n, 0.301 0.017 0.021 1.133


116 300.0 0.613 0.771 0.313 0.012 0.013 1.2S1 11,. 31Z.0 ••Sl5 G.701 0.317 0.016. 0.01' 1.U' 


111 319.0 0.1" 0.311 0 ••18 ••010 1.2'"
 I.'" 

11. 306.0 0.160 a,'fll,. 0.:1122 0 ••13 0 .... '.2413 


120 2".0 0.'" 0.659 0.315 0.014 0.0:6 1.211 


IREGUlATORY.'REPORT • 374 
90 DAY INHAlATION TOXlCI"Y STUDY IN THE RAT wrm R.BCOVER.Y PHASE 

APPENDIX 12 • INDMDUAL PATHOLOGY CROSS REFERENCE CMICROSCOPlC) 

Key: 

N.A.D. - no abnonnalities detected 

/REGULATOR.Y/REPOR.T • 375 

90 DAY INHALATION TOXlcrY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 12 .. INDMDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

JtIIII07JU. ........ RBIII&L 


DOIm I.JIYIIL. 0 lID. DLII 

... 1

1:&."67"0 

..-a!o~ ..................................................... . 
 trotoJlll,C) boDe .......... '"' ... .................................................. * .. .. .. .. .. .. .. ............. x.. .. 


AOWrA ••••••••••••••••••••••••••••••••••• ,•••••••••••••••••••••••••• 

aa.K ~w"'" ........................................• " •••••• ". 


aa.K''''+8'l'%n.:a J01ll1' .................................. " ••••••••• 


...0 ................ .................................... • •• " •••• ". 


CIII;CUIiI ................................................... ••••• • • • • • 


cor.c. ....... ........ ............. ....... .•• .............. .." ••••••• 


...... ............................. .............. ."".."... " "ID~8 .•••.•••••••.•.•••..•••..•.••....••.••..•.••••• ."." •••••• 

KYI + 1KYr...OptIC ..... •••••••••••••••••••••••••.••••••• "."."" ••• " 

••..•••............•......................••• "...... 
 1Io_.a~ 0 ...1·.taf.lltrat.t_ .......................... •••••••• 1 • 


ur, IIOItPIIOLOIIJ" D9Dlft 

• 11M IIICOIIDD 1 Id.Jdaa1 


" ••A.II. 2 IlUgIlt 
 o maaDIIQ , IIIMM:nt. 

+ ftJlID'f '1UL1:'Ird 11. ., 8QDI1'1' 

~GULArORY~ORT - 376 
•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

90 DAY lNHALATIONTOXlCfY STUDY IN 'f.Ht RAT WlTHRECOVBRY PHASE. 

APPENDIX 12 • INDIVIDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 


'AIIIIWt.L. 1IItIo&C*. ~u. 

110111: WIYIIIio. • su.........
 ... 1 l S , 

......1' ., ••••••••••••••••••••••••• , ...................... .. Degeaeratl•• c~ ••••••••••••.••••••••••••••• 

It.llClll ............................. ,. ....... .,. .. ,. ... ~ ••••• " ........ 1' .......... .,. .... . 


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APPENDIX 12 -INDMDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

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APPENDIX 12 .. INDIVIDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

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REGULATORynrnpORT - 379 
90 DAY lNHAI.ATION TOXICl'Y STUDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 12 - INCIVIDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

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APPENDIX 12 .. INDIVIDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

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APPENDIX 12 - INDIVIDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

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APPENDIX 12 -INDIVIDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

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JREGUlATORY/R.EPORT - 384 
90 DAY INHALATION TOXICfY STUDY IN THE RAT wrmRECOVERY PHASE 

APPENDIX 12 .. INDIVIDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

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APPENDIX 12 - INDMDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

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APPENDIX 12 -INDMDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

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bf~tJ._ .......................................... . 


LXVD .................................................... 

......DGl._ .. IdaaII ~~tDllT Gel.l UU!!1t::c-atl_ •••• .....tJ.U. (~..a1/-.J.tlfoaa1 J..rl_tS- _J.tla __:I..) 

ur, • IlO'l' IIIICOIIDIID • ..&.D. 

o artlUDICI • IIOUBOLOIR 1'1JISBII'I' 

l[ 110 IIIIUIllft' 

IIOItl'IIOLOGJ' BJrIBItIft' 

1 Il.I.aiM.l. 

2 .11._ 3 .aerate 

..an.. 

1 • • . • • 

•••• 0 ••••• 

. 3 

.11 

1 1 1 1 

1 

1 • • • • • • • • •

....•... +. 


• • • • • • • • 1 • 

1 • • • •• . 1 .. a .• l. 

IltEGULATORY/REPORT • 391 
•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

90 DAY INHALATION TOXIcrY STUDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 12 • INDMDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

_. I'BIIIJIfA:. 

D08II r.n:u.. uoo alt..... 


paa :I :I :I :I l :I :I :I :I 4 
 ~ Z :I 4 5 , 7 • • D 


............................................................. 
• •• + • + •••• ~v.ol&r ..oro,.... l.r~Ltr.tlOR ••••••••••••••••••••••• · .. I ..•••• 
 " __up ............................................ • •.•. 1 •••• 


LYIIRI 1IDC.-CIIIlVICUo ..................................... . + + • + 0 • • • • • 


1'1._ IIell FOurv.tloa ............................. . 11.3 .•.•• 2 


LYIIRI _·aa.'l'l:lU:c .................................... 


I'ASAf. Clt'II1'I' ........................................... .. ........... 
 ~104lol.tal. l.r~tl0............................... . • • • • • • • Z •• 


................................................. > ...... . 


,~ ................................................ . 
 'ADDDIOID CLIIIID ........................................ 


~'8 PA'1'CIII" ......................................... ••••••••• 0 


PIUUlna: ................................................. 


tJ:RI~U1! 8LNID ................................... .. .. .. •••••• + ••• 


C7.t/.................................................................... "' ........................ .. X •••.• x •• Z 


DY. IItIDIIOLOCa1 ......En _ BIOOIIDIID I ....bal. 

• ..A.D. a a1.Lgbt 

o M18aI8C :I ~.t. 

+ IIIlI!UIIOr.OCn JIRI:IIBII'l' 4 ...:tIM 


X 80 IIINIIUI'I' 


~OULATORY~RT - 392 
•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

90 DAY INHAIATION TOXIcrY STUDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 12 -INDIVIDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

JIIIIIIO'f& D:I.IIIlII, 'l'IIJIHDQL 

..,.. r.IWL. !too II1II:. IIU.B 

ppoa 3 3 3 3 3 I 3 S 3 , 

123 '-I • 7 • , • 

"''I'Aft GLAII1) ........................................... . 


h:'oataUt:l.a ............................................ 


ItIIC'!UM .......................... II .. .. .. .. .. .. .. .. .. .. .. .. _ .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. .. , .. .. .. .. .. .. 


IIIAIolVD'l &MIl ........................................... 


8Cl"'1'IC ............................................... .. 


~.l..t::I............................................... 


1IBtIJ:.a.r. 'f118ICLB .......................................... 


SJC:O (0ftD) ............................................. 

ACaatbae:l.a~toa1••••••••••••••••••••••••••••••• "J.t_1J.1Ll. _a1a .................................... bf~torJ' _11 :lJI.f:l.lt:ftC!oa •••••••••••••••••• lhIrtaoe --..t"',_tJ... • ........................... . 

.11:0 ,'18'1' J'WIoIIE........................................ 


Iil'IIl:t.L CDlItI) .............................................. 


81'L111111 ................................................... 


II'ftIIIIIUIl .Ift ... _ .................................


D'I'. • _ BOOIIDD 

• ••A.D. 

CI ....:tIN 

• I'IIIUIIII'l' It 110 1III'nIIll'lf'l' 

MOII:IIIOLOGI' IIB't'DIn 1 lI1IIiItal 

2 aUgltt 3 ~ate 

• aarJI4ICI. 

1 .. .. • .. .. .. .. .. • 

• + + + •••••• 1111 •••• 1. 

+ • • + • 

2 • 1 

2 • 

:a • • :I • • 

fflEGULATORYffiEPORT - 393 
•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

90 DAY INHAlATION TOXICfY STUDY IN THE RAT WlTII RECOVERY PHASE 

, 

APPENDIX 12· INDMDUAL PATHOLOGY CROSS ReFERENCE (MICROSCOPIC) 

.a.HO'rAL 1tI.II8OII. rmauDL 

DOSI ........ 1010 sa. Dr.Ii


.... 3SSSSSSSS' la3"'7 ••• 

II'I<lIa.CB .................................................• 


CIl.aduJ.v 4Uat.tIGD ................................... • • 1 . 1 • • • • • 


'1'18'1'18 .................................................. . ~ ........ . 
 U~t.ral t.bml.r 4e....r.t1oa ••••••••••.••••••••••••• 4.. • • • • • • • • 

ft'DIII8 ................................................... 


~D Ct.aIID ........................................... . I ••••••••• 

....___ ..,..t/. .. ...................................... • :1.:1 •• :1 ••• 

~ual-.r oe11 1a111~tiOR ••••••••••••.••••••••••••• • 1 • • • • • • . • 

'fIACJID .................................................. 


UIJWAIm BLIII.DDIIII ........................................ .. 


ftL~ ICDIICLII ......................................... ••••• + •••• 

Degeae:r.U.". .,.pat:llT/_•••al_ oal1 1a1i.l.trat108 •••• 1 •• 111 •• 1. 

1OrI. IUNIIIlII"f 


IIO'l' IIIICOUJID 1 ldaual. 
 •••I..D. 2 aUpt 


o IIIII8DIG . I .o4_te • 1I:I8JIIIOIiOG1"'1IIn' , .uIIM 
 :I .. DVIIUI"f 


IREGULATORY/REPORT - 394 
90 DAY INHALATION TOXlcrY SruDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 12 • INDIVIDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

IUIIIIOV'.t.L IBUIOII. 'lBIIIaIIUo 

DOSII LBVIIr.. 1000 sa........ 1 


ppa 
 .. . ., , , . . , 1 • 3 , & , 7 • , • 

AD..... er.NnI •••••••••••••••••••••••••••••••••••••••••••• • ••••••••• 

AOIYJ. ... ....... ................. ..... ....... ......... .... • ••••••••• 


80KI ~~.-.aa •...•..•.......•...•........••...••..... • ••••••••• 

BOIB-PBMDR~IPLI ~~ •••.••••••••••••••••.••••••••••••••••••••••• 

IUtUlI ... ................................................. • ••••••••• 


.•.......•............................•......••....•••••••••• 


CllVllt .... ...... ............ ........... ...... ............ • ••••••••• 


cor.mr .................. ........... ...... ......... ........ • ••••••••• 


DlltlNIIUIII ................................................. • ••••••••• 


+ ~1BA.orrlc ............................................... . 


IDIIDIIII1UI GLlIIID .......................................... • + • • • • • ••• 
 lIoDoauol.eal:' _11 l.dJ.It:.,.u... .............•.. . • ... •... . I • • ._. • • • . 


.....1' ....... .......... .................................... • •••••••• 11 


.....••...•.••......•......••....................... .......... 
 QI. IIIJB'IIOLOIH 11IVD.I'l'I' 


BOll' UCClItDIID 1 alIIiJIal 
 •••.J..D. 2 .u.illlat: 
 o IIIBBDMI 3 Mlluat:. + ~1IOIiCIII"'1IIII'I' ,--.. 

J: 110 1III'IUI'l'I' 

~ULATORynuwORT - 395 
•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

•••••••••• 

90 DAY INHAlATION TOXlCI'Y STUDY IN 1HE RAT WITH RECOVERY PHASE 

APPENDIX 12 - INDMDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 


JIIIIIDII'U. ....... 'I'IIIIIIl1llL 

DOIJIt urno.. 1000 

PPI 

lID. l'BEI.LII , , , , , , , , 

1236567 • 

, 

t 

1

0 

0 

u ........................................................ 


I':IIMIIlr .................................................. . + + + • + + + + + + lDtz.~ -'GCOl1tbJAa~ •••••••••••••••••••••••••••• 1111122111 

bouIopIU.11a ..................................... • 1 • 

til.&tat.loa .................................... . 3 • lDtUtlt.1t1&1 __l.ew 04111 id.1l.t:ftot.s- •••••.••••••• :a 1 •• 

1o.IIoC3DD1 I'&IIID ........................................... MDaaD.alaar oel1 ±ar'1~t.1oa •.•••••••••••••••.••••••• . 1 •••••••• 

LAa'I'B ................................ ~ ........................ * ......................." ............ .. 


Ll't"D .. ~ ................................................................ '" .................. "" ...... .. ••• 4 •••••• 

___1III.'J.l..r 01:' IIb:eI'I :I.af~tOlY oal.1 .taJ:lltz.ttoa •••• •• 111 •••• 1 

I.tI.WIIiI .................................................... . 


L.... ftDII-CUVICllL •••• , ................................. 


LJID'II _·._Ie •.....•........ _.................... 


__'I I'&IIID ............................................ 


IDAU'.o c.r.:n:n ............................................ . 


Dr. IIIIOIOIIIOLOIil'I' s:rraJ'I'J: 

• 1IM..c::oJIDIm 1 1I1a:Wa1 • ••A.II. 2 d.1pt o 1IIl88D& 3 ..a..nat. • IIODIIOLOIff PJIISD'I' .. __&II 

J: 110 ....,..In 

,REGUUTORY/REPORT . 396 

90 DAY INHALATION TOXICI'Y STUDY IN THE RATWJTH RECOVERY PHASE 


APPENDIX 12 - INDIVIDUAL PATHOLOGY CROSS REFEFENCE (MICROSCOPIC) 

JtIIHOfAL ........ 'I'IIIIIIDAL 


D08I Lh'ID.. 1000 sa. J'IDIt.U 1 ppa 1 2 3 , 5 , 7 , • • ",.,"',.

OIISOJ'IDAUS ............" .. • • • • • • • • • • • • • •• • • • • • • • • • • • • • • • • ••• I( • • • • • • 


ova:a:r .................................................... • •• I( •••••• 


1'.IIICItI:UI ••••••• • • • • • • • •• • • • • • • • .. • • • • • • •• • • .. • • • •• • • • • • • • ••• I( • • • • • • 

P<lLft!IKIID G.YD .......................• • • • • • • • • • • • • • • • • •• 0 I( • • 0 • • • 


1PInD" P.llt.'I'e:II'8 ......................................... • ••••••••• 


..................... •••••• ....................... • I( •••••••• 


PrrDJ~:r GLAaD ••••••••••••••••••••••••••••••••••••••••••• + ••• + •• + • CJ'at/. ................................................. • It • • • :It • • .'I 

DC..,. ••. .................................... ............ • ••••••••• 


BlLIVAl:r GLIaD ••••••••••••••••••••••••••••••••••••••••••••••••••••• 

&Curle IIIIIlV1I ............................................ •• + • • • + • + + 
 .,..,..1.....1::1._ .......................................... •• 1 • • • 1 • 1 1 


Sll:III (IICIIB'I' FLIIIlItJ ....................................... • •• II •••••• 


SPIll... COIID .............................................. •••••••••• 


DJ'I lIOumr.c:G'I' nvDlft 


• • 

. .or 

.A.D. 

UCOJIDIa) 

2 

1 

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~ 

o IaIlllDN s -a.rat.. + 1mIIJ!BOLOGI' n:IIIIIDI'f 4..n:", 
 :II: 110 IIBY.IIIIft 


IR.EGULATORY/REPORT - 'YJ7 
90 DAY INHAlATION TOXICI'Y STUDY IN THB RAT WITH RECOVERY PHASE 

APPENDIX 12 - INDIVIDUAL PATHOLOGY CROSS REFERENCE (MICROSCOPIC) 

...,..... 1IID8OII. lrDKIlU.L 

D08I~.

,..

1000 8KZ. I'alILI: 1 
 I I I • I I I • t 0 


1 2 3 4 S , 7 I I 0 


..L118 ............................................................ . 


8'l'J11mU11 1fI'I'll BOllI __ .................................. • ••••••••• 


IIflIIIGa .................................................. .......... . 
 1IlAa4aJ.a:&- Ul.baU.. ................................... ••••••• 1 • • 


'I'JI11IIIB ............................................__ .. • .. ••••• • • ••• 


'I'IIIaOJD ;LaIID ................................... __ • .. ..• • •• + + + • • • •• 
 ...-,.. CJ71Ot/...............--.......... ........ .. .... " J: J: It 


.....••..•.•......................................•••••••••• 

VI~ BLADDIR ••••••••••••••••••••••••••.••••••••••••••••••••••••• 

U1IaE8& ••••••••••••••••••••••••••••••••••••••••••••••••••• • •• + •••••• 81C11<talU tilatat.t... • ........................... ,...... ••• • 1 • L...t.a&1 tilat.tlaa ..................................... ••• 2 • • • • • • 

'lMDa •••• ..... ............ ............ .............. .... • ••••••••• 


vo......r.uBCLB •••.••••.••••••.•••••••.•••••.••••••••••• + •••••• + •• .,......U .. JI,f......tIly/_._l6v 0.11 iDf.t.1U.U... •••• 1 1 • • . • .' 1 • • 

IllY. IIJIIIIBOLOIiIf 8Ir9DI'I'I' 

• 

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1 

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~ 

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• -......oer ........ 4 ...... 
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nwGULA~RYnrnPORT - 3~ 
90 DAY INHAlATION TOXICIY STUDY IN TIlE RAT WITII RECOVERY PHASE 

APPENDIX 13 -INDMDUAL PATHOLOGY DATA 

Key: 

NO - number 

wks . weeks 

M - male 

F • female 

NAD . no abnonnalities detected 

EXAM· examined 

JRBGUlATORYIREPORT - 399 

~ c::: 

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APPENDIX 13 - INDMDUAL PATHOLOGY DATA 

DDIII.L 110. IW nvPJ'. PI __ U ....., :& lIDr 1111 001II:. o PIlI! 

IIl:CIIOU'IIIOL08'I 

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....ba.1u' b.aopkU..ta • (1II.a1Ml , lIDJ.latUa.1) LlYD 

IIIopIItiUa Uoca1/.a1Ufooa.1 ba-_.uOII "U.II .--Sa, • hUtlbt) S::Ut'IC MIln'I: 

-,..u....u_ I ( ....ia&l.) 

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------------------------------------.--.-----------••--..0 or ~IKaL···-------·--·--·--------------·------··--------·--------------

~GULATDRYffiEPORT - 40~ 
~ 

i 

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11 "JIll; ..

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APPENDIX 13 ~ INDIVIDUAL PATHOLOGY DATA 

.llllXIIAL H. s sa. Jl \:101m. o - .. SIVD1'. .:1 CIa.,. (14 ...., 'I'IIIIImIAL 

UCJlO....BIOLOItt 

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'h'bwl.ll:l:' ....GIpIlllla • (~ f 1aUat....1Il.l 

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IIoepat1U. U~'-.J.tUocal. 1:a.e~t1_ IIIltil _la, • (~) 

___ka&' OZ' 111-.1 1:a.e~torJ' _U iDftl.tJlatloa • (1dalaaJ. , roca].) 

L'IIIPII 1IImB-a.:ncu. .~ -U piI01U_UOD • (aliglllt, .1IOft...U ....., 

Proatat1tl. • (-ta~) 

seD/fIC .... 

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--...---.-----------.-------------------.-.--...----.---.D or AI~-------·----·-·------·--·----·---·····----·······------.----- ... 

/REGUlATORY/REPORT . 405 
---

11 11'111! II 

'15 iil~111 

I nl- '.. I ~ 

:1 iEi-~'i iiI' i~ aigll I I-~ il '~~ii I all 

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90 DAY INHAlATION rOXICIY STUDY IN THE RAT wrmRECOVERY PHASE 

APPENDIX 13 - INDIVIDUAL PATHOLOGY DATA 

_DIAL 11), " lIDI. DOIIIII ~ Q PJII _ 8ftD1!. II (U wit.) UIIIIDIIoL

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ItE.... 

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raba.laII' buopll.t.ll& • ,~ F _U.atual.) 

FIOS'tAD GUIlD __1ear <MIll .t.aI'Ut&'at:l_ • '_Upt:1 8:UIUC lIDO 

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Dtl.geaU'atlft 1IJOPIlt:b7/_oauol.M.r .011 lAt!Ut&'atlOD • (~) 

..---~--- ..---------------------------.--.-...---------KID or ~------------------•• -••-.-.--••-------••-----------.-.---••-.--­

~ULATORY~ORT - 407 
• 
90 DAY INHAlATION TOXICTY STIJDY IN TIlE RAT WITH RECOVERY PHASE 

APPENDIX 13 - INDMDUAL PATHOLOGY DATA 

UDIAL ." I lID,. 0081:. .. ... _ 8ftIJ'. 12 ay. (14 1duI) !mIIIIIIAl'. 

IIIC11Ol'a'l'llOLOlD 

ItIl*D' .......,.... ba-OJb1U& I (1Iia.taaJ.) 

LI'ID 

.......UU.. '~_IllJ-.l.tU_al Uft_tlaa nth _I.) , CIlU1aalI 
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ffiEGULA10RY~ORT - 400 
.. 

• 
90 DAY INHAlATION TOXlCIY S11IDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 13 .. INDIVIDUAL PATHOLOGY DATA 

AllDIUo •• o (ilia 011 .IORI , lID.. DOH. "2 -J'1I (14 ...) 'rDKIIW'o

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APPENDIX 13 .. INDIVIDUAL PATHOLOGY DATA 

UDAL 10. BU.. DQA, o ppa W I'I'lDr. u (14 wlI:.) IIIIIIOlIA& 

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....---.. --.--...-......---.---.. -.----------..---------.D OP lIII'~-.-----.--.--- ..--------..--.-.----------,--------------------­

IREGULATORY/REPORT - 415 

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.. 

o 
90 DAY INHALATION TOXICfY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 13 -INDMDUAL PATHOLOGY DATA 

AIIlIIlI.L .,. • !JU.. DOD. II ... aI II'IIIDI'. .2 d~ (1' wIta) I'IIIIIIDW. 

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IREGULATORY/REPORT - 417 

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.. 
90 DAY INHAlATION TOXICTY STUDY IN THE RAT WI1H RECOVERY PHASE 

APPENDIX 13 -INDMDUAL PATHOLOGY DATA 

-'IIDI'&L 1101 10 8U.1. D08l11 o lIP' <W 8ftH1 .2 CIQ'II (14 ....) l'DKIDL 

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~GULATORY~PORT . 419 
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APPENDIX 13 -INDIVIDUAL PATHOLOGY DATA 

AltIDL 011 nDD'I'. fa _p U4 _aJ 110. n lID. r D08Ii. o p.- 'rJlIIIIJDL 

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-------------------------.. ---.-----------.-.-.---------.D OF AIt~---·-·-··-·--·------·······-··-······-·······---···-- ____ow_ow. 

IREGULATORY/REPORT • 421 

o 
90 DAY INHALATION TOXICIY STUDY IN THE RAT wrm RECOVERY PHASE 


APPENDIX 13 • INDIVIDUAL PATHOLOGY DATA 

UDIII.L ... 62 az. r DOIIlIo ., ppt mr 11'1V11'. t2 u.:ra «14. ...) fIIIIImIU, 

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ffiEGULATORY~ORT - 423 
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it.... 

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I 
90 DAY INHALATION TOXICl'Y STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 13· INDIVIDUAL PATHOLOGY DATA 

IIIIDL 110. 63 SIrIt. r D08II. ID "... ow S'I"IIm. .a (U 1IIb) IIIIIIQ:IIAL 

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--..--..------.--.....--..--.---------.---.-.-----.----.-D or IIIXRIL---·------_·-·_---··---···--··-----··-·_---_·-----··------._--.­

~GULATORYnwPORT - 425 

90 DAY INHALATION TOXICI'Y STUDY IN THE RAT WITH RECOVERY PHASE 


APPENDIX 13 -INDIVIDUAL PATHOLOGY DATA 

JIII:uau:. 110 I •• sa, r DOIlII. o .... _ alVDlf. t3 4&p (1f lib, 'I...:nw. 

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~GULATORY~RT - 427 
, 

.. 

• 
90 DAY INHAlATION roXICIY SI1IDY IN THE RAT Wl.TII RECOVERY PHASE 

APPENDIX 13 -INDIVIDUAL PATHOLOGY DATA 

MnIAL 110. 65 sa• ., DOSIi. o lis- a. nvD'f. '2 &aJ'II eU __I I'IDIIWIAL 

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~GULATORY~RT - 429 
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APPENDIX 13 -INDMDUAL PATHOLOGY DATA 

J.IIDI.Uo JIO. II BD.. DOBl.. o .,. .. 8!VJJ1:. 1::1 CIA,.. (U 'MIU) ~ 

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IREGULATORY/lEPORT • 431 
..... 

~ . .. 

o 
90 DAY INHAlATION TOXICfY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 13 - INDIVIDUAL PATHOLOGY DATA 

UIKU. 110. .7 81%. r DOSI. II ... C* S'rW1'. 12 _. Ut Ra) '!'JIaDl&L

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~GULATORY~ORT - 433 
• 

11 ' 
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J 
90 DAY INHALATlO}\O TOXICfY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 13 ·INDMDUAL PATHOLOGY DATA 

lUf1lCl.l:. 110. .. aa. r _. o 011' 11'IDl'. t:a _. (16 wu) PI'Il 

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~GULATORY~PORT - 435 
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11 I • Ii' 

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j 
90 DAY INHAlATION TOXICfY STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 13 • INDIVIDUAL PATHOLOGY DATA 

AIIDIAL _. 6. sa. r 1JOIq. o p.- a. 8ftJI. .z ..,.. (If ..... ) B1IIIDAL 

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ffiEGULATORY~ORT - 437 

90 DAY INHAlATION TOXICI'Y STUDY IN THE RAT WITH RECOVEJ.Y PHASE 

APPENDIX 13 • INDMDUAL PATHOLOGY DATA 

MDGI. 110. 70 1iIIrZ. I DOI!B. o PPI \w IInDr. fI"". (le.at) 'dIIIDIU 

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~GULAiORY~ORT • 439 
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APPENDIX 13 - INDIVIDUAL PATHOLOGY DATA 

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90 DAY INHALATION TOXICTY STUDY IN THE RAT WITH RECOVERY PHASE 


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APPENDIX 13 -INDIVIDUAL PATHOLOGY DATA 

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AIlIUIIIUo ......., : AIlIt'I'.I. : BOllI IIlIItIIOW-JPaIJII : IJ(IIIa-J'D.'IDt+S'l'D'LI IOD'!' : BD.DI : c:.a.BCDII I CC~ J IIUODaUII , DIDI"DlI8 , BIll + III'I'ID.OP![C ...... I DllDftIllil GLU!D ; ILIIUII I JllJUIUH I ItUIIIIT : Ll.CRDIU. GLlJI'D ; LIIIIID I LUP. IIOOI-ClllNICAL ; L'IKPII 

1K1I'I:-JiIBSliH'DlC : IIA8AL CU'In I 0ICB01'IIlIGUS I I'lIIICaDS I 1'......'I'IUX(11) GILAIID • 11 ....;1 ....) I l'B'fD'S .AIaI/. I PBUID ; PI~I'rUY 

'REGUIATORY/REPORT • 495 

90 DAY INHAlATION TOXICI'Y STUDY IN THE RAT WITH RECOVERY PHASE 

APPENDIX 13 .. INDIVIDUAL PATHOLOGY DATA 

.IIIInIlLL D. 3' aur" JIIOSII. .1 000 ... (If S'I'IIP'rr Sl2 dal'- (1...., nIIIUJIU, 

II!c:IiOI'AftIO:LOGr 

~~lI* - ftIIl I'OLLOWIIIII ~l""" .... IIJIIlDP) KAD 

fiAIII) I P"ft~ .... I ..:::lUll I 8I.LI~ i&IIQ) I senne IIIIR'ft I SIiII:DIAL VlI8tcr.. I 81111 (aIQIft' FLAllltI I II1'IIII.L COD I ..LUll I 8'!'11JtWa WDB IKD IWIIIIOW ; 8'ICID.CIl , '!'laftJB I '!'IlDIVB J '!BIJIOID GLaIID ; ft.I.CIIIIa I VIIDIU'! BJ.A.DIIm. 

I'D POLI'oCtIIlRl IaCb8COPIC «:8IIIUl'IAn.a .... laD. 

1lU&'1.,........,u_ oar41-rolllltbJ' • (a1a;WUJ 


LIYIIIt .....tU:.l. (f_l./.u1t.it!ooal. :l.D.f~t1oa wit.b. _1.) • (.Utbt) LVIIS 

"--:a:tI.tI1I& • I~ • _ltU-:L1 Hili (0ftID) 

...,..tllHb/bJ'lMZ'll;o:ntoll1. • (.u..s.a.1 I roo.J.) 

VOJiUIIDQ IIUIICU ~t:1_ IQOPetJl)'/_....'IIOl.Mr _U JdUU'aU- I (~U 

----~-----.-------.-----.-- .. ------...---..------------.-0 OP ~IKaL-·--------·------'-'-'--·--·-···---------·--·--------------.---

REGULATORY~RT • 496