Flutolanil Dietary Exposure and Risk Assessment DP Number: 371494 

PC Code: 128975 

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1

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF 

CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM

DATE: 10 Sept 2010 

SUBJECT: Flutolanil Chronic Aggregate Dietary (Food and Drinking Water) Exposure 

and Risk Assessment for the Section 3 Registration Action (Brassica Leafy 

Vegetables, Crop Group 5). 

PC Code: 128975 DP Barcode: D371494 

Decision No.: 419258 Registration No.: 10163-301 

Petition No.: 9E7612 Regulatory Action: Section 3 Registration 

Risk Assessment Type: Single Chemical/Aggregate Case No.: N/A 

TXR No.: NA CAS No.: 66332-96-5 

MRID Nos. NA 40 CFR: §180.484 

REVIEWER: Kristin Rury, Biologist 

Risk Assessment Branch 3 

Health Effects Division (7509P) 

THROUGH: Doug Dotson, Chemist 

Julie VanAlstine, Environmental Health Scientist 

Dietary Exposure Science Advisory Council (DESAC) 

Health Effects Division (7509P) 

and 

Paula Deschamp, Branch Chief 

Risk Assessment Branch 3 

Health Effects Division (7509P) 

TO: Barbara Madden, Risk Management Team 05 

 Risk Integration, Minor Use and Emergency Response Branch (RIMUERB) 

 Registration Division (7505P) 

Executive Summary

Chronic aggregate dietary (food and drinking water) exposure and risk assessments were 

conducted using the Dietary Exposure Evaluation Model, DEEM-FCIDTM, Version 2.03, 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 371494 

PC Code: 128975 

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which uses food consumption data from the U.S. Department of Agriculture’s (USDA’s) 

Continuing Surveys of Food Intakes by Individuals (CSFII) from 1994-1996 and 1998. The 

analysis was performed to support a Section 3 request for flutolanil in/on Brassica leafy 

vegetables (crop group 5) and turnip greens. 

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

No appropriate endpoint attributable to a single dose was identified. As no acute dietary 

endpoint was identified, an acute exposure analysis was not performed. 

 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization 

Tolerance level residues combined with 100% crop treated and DEEMTM 7.81 default 

processing factors were used to determine the chronic dietary exposure and risk estimates. 

The chronic dietary exposure estimates for food and drinking water are below HED’s level of 

concern for the general U.S. population (1% of the chronic population adjusted dose (cPAD)). 

The most highly exposed population subgroup was children 1 – 2 (<2% of the cPAD). 

Drinking water was incorporated directly into the dietary assessment. 

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

Flutolanil is classified as “not likely to be carcinogenic to humans,” so a cancer dietary 

assessment was not conducted 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds 

one in one million. References which discuss the acute and chronic risk assessments in more 

detail are available on the EPA/pesticides web site: “Available Information on Assessing 

Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-

AUG-1999). 

The most recent dietary risk assessment for flutolanil was conducted by S. Funk (01/04/2010, 

D364586). 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 371494 

PC Code: 128975 

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II. Residue Information

Flutolanil Use:

For the current action, HED has examined data to support the establishment of tolerances in/on 

Brassica leafy vegetables and turnip greens. 

HED's Metabolism Assessment Review Committee (MARC) met on 12/16/99 and concluded 

that the parent compound and metabolites containing the common moiety, 2-trifluoromethyl 

benzanilide, calculated as flutolanil, are the residues of concern for plants and rotational crops. 

As the enforcement method for plant commodities converts residues of flutolanil and its 

metabolites to 2-trifluoromethyl benzoic acid, tolerances for plant commodities will be set in 

terms of residues of flutolanil and its metabolites converted to 2-trifluoromethyl benzoic acid, 

calculated as flutolanil. The parent compound and metabolites, M-2, M-4, and M-7, are the 

residues of concern in animal tissues and milk. The glucuronide/sulfate conjugates of M-4 are 

also residues of concern in milk. As the enforcement analytical method determines residues of 

flutolanil and metabolites converted to 2-trifluoromethyl benzoic acid, tolerances on livestock 

commodities are established in terms of parent plus metabolites that are converted to the 

common moiety (HED MARC M. Xue, 1/6/00; Anna Lowit et al. D268880, 09/11/2000). 

Tolerances are currently established for residues of flutolanil and its metabolites converted to 

2-trifluoromethyl benzoic acid and calculated as flutolanil in/on peanut, rice, potato, milk, egg, 

soybean and cotton commodities, poultry, beef, hog, goat, horse, and sheep (40 

CFR§180.484(a)) at levels ranging from 0.05 ppm to 25.0 ppm. Inadvertent or indirect 

tolerances are also currently established for residues of flutolanil and its metabolites in/on 

wheat bran, wheat forage, wheat grain, wheat hay, and wheat straw commodities (40 

CFR§180.484(d)), at levels ranging from 0.2 ppm to 2.5 ppm. 

Residue Data Used for Chronic Assessments

The established tolerances in 40 CFR§180.484 and the recommended tolerance levels for 

Brassica leafy vegetables and turnip greens (listed below) were used to conduct the chronic 

analysis. 

Tolerances to be established under “§180.484(a) General”: 

Vegetable, brassica leafy, group 5 ......................... 0.11 ppm 

Turnip, Greens ....................................................... 0.11 ppm 

DEEMTM 7.81 default processing factors along with 100% crop treated assumptions were used 

to conduct the chronic analysis. 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 371494 

PC Code: 128975 

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III. Drinking Water Data 

The drinking residues used in the dietary assessment were provided by the Environmental Fate 

and Effects Division (EFED) in the following memorandum: “Estimated Environmental 

Concentrations (EECs) of Flutolanil on Sugar Beets, Brassica Leafy Vegetables, Turnip 

Greens, and Ginseng” (L. Liu, D370201, 7/21/2010) and were incorporated directly into this 

dietary assessment. Water residues were incorporated in the DEEM Food Commodity Intake 

Database (FCID) into the food categories “water, direct, all sources” and “water, indirect, all 

sources.” 

For surface water and groundwater, Estimated Drinking Water Concentrations (EDWCs) 

were generated from the Pesticide Root Zone Model and Exposure Analysis Modeling 

System (PRZM-EXAMs) and from a Tier I Screening Concentration In Ground Water (SCIGROW) analysis, respectively. The surface and groundwater EDWCs are shown in Table 1. 

At the time the EDWCs were generated, flutolanil was proposed for use on sugar beets, 

Brassica leafy vegetables, turnip greens and ginseng, with the highest application rate for 

flutolanil being on ginseng. The mean surface water concentration of 8.5 (ppb) from 

application to ginseng was entered as a conservative point estimate in the chronic residue file 

editor for DEEM-FCIDTM. While the proposed use of flutolanil on ginseng has been 

withdrawn, the drinking water analysis incorporating the use of flutolanil on ginseng was 

used in the dietary assessment as a conservative, screening level analysis. 

Table 1. Recommended Surface and Groundwater Concentrations 

Agricultural Setting Surface Water Concentrations Groundwater Concentrations (ppb) 

1 in 10 year Peak 

EDWC (ppb) 

1 in 10 year 

Annual EDWC 

(ppb) Ginseng 

12.7 8.5 

0.7 

IV. DEEM-FCIDTM Program and Consumption Information

Flutolanil chronic dietary exposure assessments were conducted using the Dietary Exposure 

Evaluation Model software with the Food Commodity Intake Database DEEMFCIDTM,Version 2.03 which incorporates consumption data from USDA’s Continuing Surveys 

of Food Intakes by Individuals (CSFII), 1994-1996 and 1998. The 1994-96, 98 data are based 

on the reported consumption of more than 20,000 individuals over two non-consecutive survey 

days. Foods “as consumed” (e.g., apple pie) are linked to EPA-defined food commodities (e.g. 

apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, 

baked) using publicly available recipe translation files developed jointly by USDA/ARS and 

EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. 

population and within population subgroups, but for acute exposure assessment are retained as 

individual consumption events. Based on analysis of the 1994-96, 98 CSFII consumption 

data, which took into account dietary patterns and survey respondents, HED concluded that it 

is most appropriate to report risk for the following population subgroups: the general U.S. 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 371494 

PC Code: 128975 

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population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

adults 20-49, females 13-49, and adults 50+ years old. 

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake 

estimate. The resulting residue intake estimate for each food/food form is summed with the 

residue intake estimates for all other food/food forms on the commodity residue list to arrive at 

the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as 

a percent of the cPAD. This procedure is performed for each population subgroup. 

V. Toxicological Information 

The doses and endpoints for dietary risk assessment were selected by the flutolanil risk 

assessment team. A summary of this information is presented in Table 2. Flutolanil has been 

classified as “not likely to be carcinogenic to humans.” A quantitative carcinogenic dietary 

analysis is not required. 

Subchronic and chronic toxicity studies showed that the primary effects of flutolanil are 

increases in liver weight combined with decreases in body weight. The available data for 

flutolanil do not show neurotoxic, carcinogenic, or mutagenic effects. Flutolanil is not a 

developmental or reproductive toxicant. There is no evidence of increased susceptibility of rat 

or rabbit fetuses to in-utero exposure or rat pups to post-natal exposure to flutolanil. No toxic 

effects were observed in studies in which flutolanil was administered by the dermal routes of 

exposure. The FQPA Safety Factor for flutolanil was reduced to 1X because there was no 

increased sensitivity to fetuses as compared to maternal animals in the developmental rat and 

rabbit studies and no increased sensitivity to pups as compared to adults in a multi-generation 

reproduction study in rats (M. Ottley et al, D349580, 08/07/2008). 

The doses and toxicological endpoints selected for various exposure scenarios are summarized 

below. 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 371494 

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Table 2: Summary of Toxicological Doses and Endpoints for Flutolanil for Use in Dietary Exposure Risk 

Assessments 

Exposure/ 

Scenario 

Point of 

Departure 

Uncertainty/FQPA 

Safety Factors 

RfD, PAD, Level of 

Concern Study and Toxicological Effects 

Acute Dietary 

(All 

Populations ) 

N/A N/A N/A No appropriate endpoint was 

identified in the oral toxicity 

studies including developmental 

toxicity studies in rats and rabbits. 

This risk assessment is not

required. 

Chronic 

Dietary (All 

Populations) 

NOAEL= 

50 

mg/kg/day 

UFA= 10x 

UFH=10x 

FQPA SF= 1x 

Chronic RfD = 0.5 

mg/kg/day 

cPAD = 0.5 

mg/kg/day 

Chronic toxicity in dog 

LOAEL = 1250 mg/kg/day based 

on increase of clinical toxic signs 

(emesis, salivation, and soft 

stool), lower body weight gains 

and decreased food consumption ] 

Cancer (oral, 

dermal, 

inhalation) 

Classification: “Not likely to be Carcinogenic to Humans” based on the absence of significant 

tumor increases in two adequate rodent carcinogenicity studies. 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to 

mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. 

NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = 

extrapolation from animal to human (intraspecies). UFH = potential variation in sensitivity among members of the human 

population (interspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = 

reference dose. 

VI. Results/Discussion 

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% 

of the PAD. The DEEM-FCIDTM analyses estimate the dietary exposure of the U.S. 

population and various population subgroups. The results reported in Table 3 are for the 

general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, 

youth 13-19, females 13-49, adults 20-49, and adults 50+ years. Tolerance level residues, 

100% CT, and DEEMTM 7.81 default processing factors were used to determine the chronic 

dietary exposure and risk estimates. This assessment showed that for all included 

commodities, the chronic risk estimates were below the Agency’s level of concern (<100% 

cPAD) for the general U.S. population (<1% of the cPAD) and all population subgroups (<2% 

cPAD) listed in Table 3. The most highly exposed population subgroup was children 1 – 2 

years of age at <2% of the cPAD. 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 371494 

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Table 3: Summary of Dietary (Food and Drinking Water) Exposure and Risk for 

Flutolanil 

Chronic Dietary 

Population Subgroup Dietary Exposure 

(mg/kg/day) % cPAD 

General U.S. Population 0.003127 <1 

All Infants (< 1 year old) 0.007005 1.4 

Children 1-2 years old 0.007530 1.5 

Children 3-5 years old 0.006337 1.3 

Children 6-12 years old 0.004258 <1 

Youth 13-19 years old 0.002850 <1 

Adults 20-49 years old 0.002818 <1 

Adults 50+ years old 0.001964 <1 

Females 13-49 years old 0.002418 <1 

VII. Characterization of Inputs/Outputs 

As the exposure estimates to all population subgroups were low, it was not necessary to make 

refinements to the chronic dietary analysis. Further refinement to the analysis could be made 

through the use of percent crop treated, anticipated residues, empirical processing factors, 

and/or monitoring data. 

VIII. Conclusions 

Based on extremely conservative assumptions, the chronic dietary (food and water) risk 

estimates are well below HED’s level of concern for the general U.S. population and all 

population subgroups, including those comprised of infants and children. 

IX. List of Attachments 

Attachment 1: Chronic Food and Water Residue Input File. 

Attachment 2: Chronic Results File. 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 371494 

PC Code: 128975 

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Attachment 1: Chronic Food and Water Residue Input file 

Filename: C:\DEEMFCID\Flutolanil\flutolanil Brassica Sept 2010.R98 

Chemical: FLUTOLANIL 

RfD(Chronic): .5 mg/kg bw/day NOEL(Chronic): 50 mg/kg bw/day 

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day 

Date created/last modified: 09-09-2010/11:58:32/8 Program ver. 2.03 

Comment: update for seed treatment use: cottonseed; soybeans. Sugar beet is non-food 

use for seed treatment. 

-------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ ------- 

01032960 1C Potato, chips 0.200000 1.000 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.200000 6.500 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.200000 6.500 1.000 

01032980 1C Potato, flour 0.200000 6.500 1.000 

01032981 1C Potato, flour-babyfood 0.200000 6.500 1.000 

01032990 1C Potato, tuber, w/peel 0.200000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.200000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.200000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.200000 1.000 1.000 

05010610 5A Broccoli 0.110000 1.000 1.000 

05010611 5A Broccoli-babyfood 0.110000 1.000 1.000 

05010620 5A Broccoli, Chinese 0.110000 1.000 1.000 

05010640 5A Brussels sprouts 0.110000 1.000 1.000 

05010690 5A Cabbage 0.110000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 0.110000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 0.110000 1.000 1.000 

05010830 5A Cauliflower 0.110000 1.000 1.000 

05011960 5A Kohlrabi 0.110000 1.000 1.000 

05020630 5B Broccoli raab 0.110000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 0.110000 1.000 1.000 

05021170 5B Collards 0.110000 1.000 1.000 

05021940 5B Kale 0.110000 1.000 1.000 

05022290 5B Mustard greens 0.110000 1.000 1.000 

05023180 5B Rape greens 0.110000 1.000 1.000 

05023890 5B Turnip, greens 0.110000 1.000 1.000 

06003470 6 Soybean, seed 0.200000 1.000 1.000 

06003480 6 Soybean, flour 0.200000 1.000 1.000 

06003481 6 Soybean, flour-babyfood 0.200000 1.000 1.000 

06003490 6 Soybean, soy milk 0.200000 1.000 1.000 

06003491 6 Soybean, soy milk-babyfood or in 0.200000 1.000 1.000 

06003500 6 Soybean, oil 0.200000 1.000 1.000 

06003501 6 Soybean, oil-babyfood 0.200000 1.000 1.000 

15003230 15 Rice, white 7.000000 1.000 1.000 

15003231 15 Rice, white-babyfood 7.000000 1.000 1.000 

15003240 15 Rice, brown 7.000000 1.000 1.000 

15003241 15 Rice, brown-babyfood 7.000000 1.000 1.000 

15003250 15 Rice, flour 7.000000 1.000 1.000 

15003251 15 Rice, flour-babyfood 7.000000 1.000 1.000 

15003260 15 Rice, bran 10.000000 1.000 1.000 

15003261 15 Rice, bran-babyfood 10.000000 1.000 1.000 

15004010 15 Wheat, grain 0.050000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.050000 1.000 1.000 

15004020 15 Wheat, flour 0.050000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.050000 1.000 1.000 

15004030 15 Wheat, germ 0.050000 1.000 1.000 

15004040 15 Wheat, bran 0.200000 1.000 1.000 

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 371494 

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21000460 M Beef, meat byproducts 0.050000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.050000 1.000 1.000 

21000470 M Beef, fat 0.100000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.100000 1.000 1.000 

21000480 M Beef, kidney 1.000000 1.000 1.000 

21000490 M Beef, liver 2.000000 1.000 1.000 

21000491 M Beef, liver-babyfood 2.000000 1.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.050000 1.000 1.000 

23001710 M Goat, fat 0.100000 1.000 1.000 

23001720 M Goat, kidney 1.000000 1.000 1.000 

23001730 M Goat, liver 2.000000 1.000 1.000 

24001890 M Horse, meat 0.050000 1.000 1.000 

25002900 M Pork, meat 0.050000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 

25002910 M Pork, skin 0.050000 1.000 1.000 

25002920 M Pork, meat byproducts 0.050000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.050000 1.000 1.000 

25002930 M Pork, fat 0.100000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.100000 1.000 1.000 

25002940 M Pork, kidney 1.000000 1.000 1.000 

25002950 M Pork, liver 2.000000 1.000 1.000 

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.050000 1.000 1.000 

26003410 M Sheep, fat 0.100000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.100000 1.000 1.000 

26003420 M Sheep, kidney 1.000000 1.000 1.000 

26003430 M Sheep, liver 2.000000 1.000 1.000 

27002220 D Milk, fat 0.050000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.050000 1.000 1.000 

27012230 D Milk, nonfat solids 0.050000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

27022240 D Milk, water 0.050000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.050000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

40000930 P Chicken, meat 0.050000 1.000 1.000 

40000931 P Chicken, meat-babyfood 0.050000 1.000 1.000 

40000940 P Chicken, liver 0.050000 1.000 1.000 

40000950 P Chicken, meat byproducts 0.050000 1.000 1.000 

40000951 P Chicken, meat byproducts-babyfoo 0.050000 1.000 1.000 

40000960 P Chicken, fat 0.050000 1.000 1.000 

40000961 P Chicken, fat-babyfood 0.050000 1.000 1.000 

40000970 P Chicken, skin 0.050000 1.000 1.000 

40000971 P Chicken, skin-babyfood 0.050000 1.000 1.000 

50003820 P Turkey, meat 0.050000 1.000 1.000 

50003821 P Turkey, meat-babyfood 0.050000 1.000 1.000 

50003830 P Turkey, liver 0.050000 1.000 1.000 

50003831 P Turkey, liver-babyfood 0.050000 1.000 1.000 

50003840 P Turkey, meat byproducts 0.050000 1.000 1.000 

50003841 P Turkey, meat byproducts-babyfood 0.050000 1.000 1.000 

50003850 P Turkey, fat 0.050000 1.000 1.000 

50003851 P Turkey, fat-babyfood 0.050000 1.000 1.000 

50003860 P Turkey, skin 0.050000 1.000 1.000 

50003861 P Turkey, skin-babyfood 0.050000 1.000 1.000 

60003010 P Poultry, other, meat 0.050000 1.000 1.000 

60003020 P Poultry, other, liver 0.050000 1.000 1.000 

60003030 P Poultry, other, meat byproducts 0.050000 1.000 1.000 

60003040 P Poultry, other, fat 0.050000 1.000 1.000 

60003050 P Poultry, other, skin 0.050000 1.000 1.000 

70001450 P Egg, whole 0.050000 1.000 1.000 

70001451 P Egg, whole-babyfood 0.050000 1.000 1.000 

70001460 P Egg, white 0.050000 1.000 1.000 

70001461 P Egg, white (solids)-babyfood 0.050000 1.000 1.000 

70001470 P Egg, yolk 0.050000 1.000 1.000 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 371494 

PC Code: 128975 

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70001471 P Egg, yolk-babyfood 0.050000 1.000 1.000 

86010000 O Water, direct, all sources 0.008500 1.000 1.000 

86020000 O Water, indirect, all sources 0.008500 1.000 1.000 

95001280 O Cottonseed, oil 0.200000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.200000 1.000 1.000 

95002630 O Peanut 0.500000 1.000 1.000 

95002640 O Peanut, butter 0.500000 1.890 1.000 

95002650 O Peanut, oil 0.500000 1.000 1.000 
Flutolanil Dietary Exposure and Risk Assessment DP Number: 371494 

PC Code: 128975 

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Attachment 2: Chronic Results File 

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for FLUTOLANIL (1994-98 data) 

Residue file name: C:\DEEMFCID\Flutolanil\flutolanil Brassica Sept 2010.R98 

 Adjustment factor #2 NOT used. 

Analysis Date 09-09-2010/14:07:32 Residue file dated: 09-09-2010/11:58:32/8 

Reference dose (RfD, Chronic) = .5 mg/kg bw/day 

COMMENT 1: Update for brassica use 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- --------------- 

U.S. Population (total) 0.003127 0.6% 

U.S. Population (spring season) 0.003156 0.6% 

U.S. Population (summer season) 0.003192 0.6% 

U.S. Population (autumn season) 0.003080 0.6% 

U.S. Population (winter season) 0.003080 0.6% 

Northeast region 0.003516 0.7% 

Midwest region 0.002600 0.5% 

Southern region 0.002704 0.5% 

Western region 0.004013 0.8% 

Hispanics 0.004847 1.0% 

Non-hispanic whites 0.002414 0.5% 

Non-hispanic blacks 0.003209 0.6% 

Non-hisp/non-white/non-black 0.010478 2.1% 

All infants (< 1 year) 0.007005 1.4% 

Nursing infants 0.003979 0.8% 

Non-nursing infants 0.008154 1.6% 

Children 1-6 yrs 0.006613 1.3% 

Children 7-12 yrs 0.004016 0.8% 

Females 13-19 (not preg or nursing) 0.002322 0.5% 

Females 20+ (not preg or nursing) 0.002131 0.4% 

Females 13-50 yrs 0.002641 0.5% 

Females 13+ (preg/not nursing) 0.003501 0.7% 

Females 13+ (nursing) 0.003121 0.6% 

Males 13-19 yrs 0.003339 0.7% 

Males 20+ yrs 0.002883 0.6% 

Seniors 55+ 0.001877 0.4% 

Children 1-2 yrs 0.007530 1.5% 

Children 3-5 yrs 0.006337 1.3% 

Children 6-12 yrs 0.004258 0.9% 

Youth 13-19 yrs 0.002850 0.6% 

Adults 20-49 yrs 0.002818 0.6% 

Adults 50+ yrs 0.001964 0.4% 

Females 13-49 yrs 0.002418 0.5% 

-------------------------------------------------------------------------------