----

----

| Delaware                        |   | 14-1745197          |
|---------------------------------|--------|---------------------|
| (State or other jurisdiction of |   | (I.R.S. Employer    |
| incorporation or organization)  |   | Identification No.) |

| 12 Bow Street, Cambridge,                | 02138      |
|------------------------------------------|------------|
| Massachusetts                            | (Zip Code) |
| (Address of principal executive offices) |       |

----

|                            |   | Director       | Position with                                              |
|---------------------------------|--------|----------------|------------------------------------------------------------|
| Name                            | Age    | Since          | Company                                                    |
|                            |   |           |                                                       |
| John Alam, M.D                  | 50     | September 2011 | Director                                                   |
| John L. Brooks III              | 61     | September 2011 | Director                                                   |
| Zen Chu                         | 40     | September 2011 | Director                                                   |
| Richard L. Franklin, M.D., Ph.D | 66     | December 2000  | Chief Executive Officer, President, Secretary and Director |
| Joerg Gruber                    | 51     | April 2007     | Chairman of the Board                                      |
| Brock Reeve                     | 54     | September 2011 | Director                                                   |

----

----

| Name and Principal Position               |   | Year   |   | Salary ($) |    |   |   Stock Awards($) |   |   | Option Awards (1) ($) |   |   | All Other Compensation (2)($) |   |   | Total ($) |    |
|-------------------------------------------|--------|--------|--------|-----------------|---------|--------|-----------------------------|--------|--------|-----------------------|--------|--------|------------------------------------|--------|--------|----------------|---------|
|                                      |   |   |   |            |    |   |                        |   |   |                  |   |   |                               |   |   |           |    |
| Richard L. Franklin, MD                   |   | 2011   |   |            | 0       |   |                        |   | 12,500 | (3)                   |   |   | 0                                  |   |   |           | 60,000  | (4) |   |   | 72,500 |   |
| Chief Executive                           |   | 2010   |   |            | 0       |   |                        |   | 22,812 | (3)                   |   |   | 0                                  |   |   |           | 94,188  | (4) |   |   | 117,000 |   |
| Officer, President & Secretary   |   |   |   |            |    |   |                        |   |   |                  |   |   |                               |   |   |           |    |   |   |   |   |   |
|                                      |   |   |   |            |    |   |                        |   |   |                  |   |   |                               |   |   |           |    |   |   |   |   |   |
| John M. Benson                            |   | 2011   |   |            | 133,700 |   |                        |   | 0      |                  |   |   | 33,700                             |   |   |           | 5,300   |   |   |   | 172,700 |   |
| CFO & Treasurer                       |   | 2010   |   |            | 131,550 |   |                        |   | 0      |                  |   |   | 7,300                              |   |   |           | 5,400   |   |   |   | 144,250 |   |
|                                      |   |   |   |            |    |   |                        |   |   |                  |   |   |                               |   |   |           |    |   |   |   |   |   |
| Robert P. Hickey (5)                      |   | 2011   |   |            | 0       |   |                        |   | 0      |                  |   |   | 46,300                             |   |   |           | 82,800  |   |   |   | 129,100 |   |
|  President, CEO  & CFO |   | 2010   |   |            | 288,800 |   |                        |   | 0      |                  |   |   | 18,600                             |   |   |           | 14,200  |   |   |   | 321,600 |   |
|                                      |   |   |   |            |    |   |                        |   |   |                  |   |   |                               |   |   |           |    |   |   |   |   |   |
| Eli Pines, Ph. D. (5)                     |   | 2011   |   |            | 0       |   |                        |   | 0      |                  |   |   | 36,100                             |   |   |           | 133,900 |   |   |   | 170,000 |   |
|   Vice President and            |   | 2010   |   |            | 225,500 |   |                        |   | 0      |                  |   |   | 11,200                             |   |   |           | 0       |   |   |   | 236,700 |   |
|   Chief Scientific Officer      |   |   |   |            |    |   |                        |   |   |                  |   |   |                               |   |   |           |    |   |   |   |   |   |

| (1)   | Amounts shown in the Option Awards column reflect the aggregate grant date fair value of grants of stock options to each of the listed officers in the years shown, computed in accordance with FASB ASC Topic 718, excluding the effect of estimated forfeitures related to service-based vesting conditions. For additional information on the valuation assumptions with respect to the 2011 grants, refer to Note F [6] of the Company’s financial statements in the Form 10-K for the year ended December 31, 2011, as filed with the SEC. For information on the valuation assumptions with respect to grants made in 2010, refer to Note G [3] of the Company’s financial statements in the Form 10-K for the year ended December 31, 2010.  For 2010, the amounts shown reflect values of stock option grants that are subject to performance-based vesting conditions, based on the estimated probable outcome of such conditions at the time of the grant.  Assuming full vesting of these stock options, the amounts shown for these stock options would have been:  For Mr. Hickey, $35,400 in 2010, for Dr. Pines, $20,200 in 2010, and for Mr. Benson, $10,100 in 2010. |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| (2)   | This column reflects the total amount of other compensation. The amounts comprise our company’s contributions to the 401(k) plan (Mr. Hickey and Mr. Benson), life insurance and disability income premiums (Mr. Hickey in 2010 only), severance payments (Mr. Hickey and Dr. Pines), consulting fees (Mr. Hickey, Dr. Franklin and Dr. Pines) and the cash portion of director fees (Dr. Franklin). |
|-----------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (3)   | Dr. Franklin’s 2011 Stock Awards amount is comprised of $12,500 in director fees paid in shares of common stock based on the fair market value as of the last trading day of the applicable quarter. This arrangement ceased on our merger with Pathfinder, LLC.  Dr. Franklin’s 2010 Stock Awards amount is comprised of $22,812 in director fees paid in shares of common stock based on the fair market value as of the last trading day of the applicable quarter. |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (4)   | Dr Franklin’s 2011 All Other Compensation is comprised of $60,000 in consulting fees which began on the merger with Pathfinder, LLC. Dr. Franklin’s 2010 All Other Compensation amount is comprised of $92,000 in consulting fees and $2,188 in director fees. |
|-----------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (5)   | Mr. Hickey’s and Dr. Pines’ executive roles with our company ceased in early January 2011. |
|-----------------|--------------------------------------------------------------------------------------------------------|

| Name                    |   | Number of Securities Underlying Unexercised Options (#) Exercisable |      |   | Number of Securities Underlying Unexercised Options (#) Unexercisable |   |    | Equity Incentive Plan Awards: Number of Securities Underlying Unexercised Unearned Options (#) |   |   | Options Exercise Price ($) |   | Option Expiration Date |
|-------------------------|--------|---------------------------------------------------------------------|-----------|--------|-----------------------------------------------------------------------|--------|---------|------------------------------------------------------------------------------------------------|--------|--------|----------------------------|--------|------------------------|
|                    |   |                                                                |      |   |                                                                  |   |    |                                                                                           |   |   |                       |   |                   |
| Richard L. Franklin, MD |   |                                                                | 125,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.36 |   | 4/22/2012 |
|                    |   |                                                                | 75,000    |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.80 |   | 5/08/2016 |
|                    |   |                                                                | 65,000    |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.85 |   | 4/23/2017 |
|                    |   |                                                                | 65,000    |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.49 |   | 4/25/2018 |
|                    |   |                                                                | 2,449,987 |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.05 |   | 12/15/2015 |
|                    |   |                                                                | 2,779,987 |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   |   |   |   |
|                    |   |                                                                |      |   |                                                                  |   |    |                                                                                           |   |   |                       |   |                   |   |   |   |   |
| John M. Benson          |   |                                                                | 150,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 1.16 |   | 9/11/2016 |
|                    |   |                                                                | 100,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.80 |   | 2/16/2017 |
|                    |   |                                                                | 100,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.41 |   | 1/18/2018 |
|                    |   |                                                                | 50,000    |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.10 |   | 2/23/2019 |
|                    |   |                                                                | 62,500    |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.13 |   | 1/17/2020 |
|                    |   |                                                                | 100,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.11 |   | 2/28/2020 |
|                    |   |                                                                | 250,000   |   |                                                                  |   | 750,000 | (1)                                                                                            |   |   | -                          |   |                   |   | 0.05 |   | 9/16/2021 |
|                    |   |                                                                | 812,500   |   |                                                                  |   | 750,000 |                                                                                           |   |   |                       |   |                   |   |   |   |   |
|                    |   |                                                                |      |   |                                                                  |   |    |                                                                                           |   |   |                       |   |                   |   |   |   |   |
| Robert P. Hickey        |   |                                                                | 200,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.55 |   | 2/13/2012 |
|                    |   |                                                                | 200,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.65 |   | 2/13/2012 |
|                    |   |                                                                | 500,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.36 |   | 2/13/2012 |
|                    |   |                                                                | 780,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.80 |   | 2/13/2012 |
|                    |   |                                                                | 100,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.41 |   | 2/13/2012 |
|                    |   |                                                                | 37,500    |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.43 |   | 2/13/2012 |
|                    |   |                                                                | 105,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.10 |   | 2/13/2013 |
|                    |   |                                                                | 150,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.13 |   | 2/13/2013 |
|                    |   |                                                                | 1,312,500 |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.06 |   | 9/2/2014 |
|                    |   |                                                                | 3,385,000 |   |                                                                  |   |    |                                                                                           |   |   |                       |   |                   |   |   |   |   |
|                    |   |                                                                |      |   |                                                                  |   |    |                                                                                           |   |   |                       |   |                   |   |   |   |   |
| Eli Pines, PhD          |   |                                                                | 200,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.55 |   | 12/31/2012 |
|                    |   |                                                                | 200,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.65 |   | 12/31/2012 |
|                    |   |                                                                | 230,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.36 |   | 12/31/2012 |
|                    |   |                                                                | 510,000   |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.80 |   | 12/31/2012 |
|                    |   |                                                                | 60,000    |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.41 |   | 12/31/2012 |
|                    |   |                                                                | 18,000    |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.43 |   | 12/31/2012 |
|                    |   |                                                                | 60,000    |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.10 |   | 12/31/2013 |
|                    |   |                                                                | 90,000    |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   | 0.13 |   | 12/31/2013 |
|                    |   |                                                                | 1,024,783 |   |                                                                  |   |    |                                                                                           |   |   |                       |   |                   |   | 0.06 |   | 9/2/2014 |
|                    |   |                                                                | 2,392,783 |   |                                                                  |   | -       |                                                                                           |   |   | -                          |   |                   |   |   |   |   |
|                    |   |                                                                |      |   |                                                                  |   |    |                                                                                           |   |   |                       |   |                   |   |   |   |   |

| (1)   | These stock options vest and become exercisable in three equal annual installments commencing September 2012. |
|-----------------|---------------------------------------------------------------------------------------------------------------|

----

----

----

| Name                      |   | Fee Earned or Paid in Cash ($) |   |   | Stock Awards($) |   |   | Total ($) |   |
|---------------------------|--------|--------------------------------|--------|--------|-----------------|--------|--------|-----------|--------|
|                      |   |                           |   |   |            |   |   |      |   |
| Joerg Gruber              |   |                           | 0      |   |            |   | 7,500  |      |   |   | 7,500 |   |
|                      |   |                           |   |   |            |   |   |      |   |   |   |   |
| John Alam                 |   |                           | 10,000 |   |            |   | 0      |      |   |   | 10,000 |   |
|                      |   |                           |   |   |            |   |   |      |   |   |   |   |
| John L. Brooks III        |   |                           | 10,000 |   |            |   | 0      |      |   |   | 10,000 |   |
|                      |   |                           |   |   |            |   |   |      |   |   |   |   |
| Zen Chu                   |   |                           | 10,000 |   |            |   | 0      |      |   |   | 10,000 |   |
|                      |   |                           |   |   |            |   |   |      |   |   |   |   |
| Brock Reeve               |   |                           | 10,000 |   |            |   | 0      |      |   |   | 10,000 |   |
|                      |   |                           |   |   |            |   |   |      |   |   |   |   |
| David G.P. Allan (1)      |   |                           | 5,000  |   |            |   | 20,000 |      |   |   | 25,000 |   |
|                      |   |                           |   |   |            |   |   |      |   |   |   |   |
| Barry R. Frankel (1)      |   |                           | 7,000  |   |            |   | 23,000 |      |   |   | 30,000 |   |
|                      |   |                           |   |   |            |   |   |      |   |   |   |   |
| Walter R. Maupay, Jr. (1) |   |                           | 5,000  |   |            |   | 20,000 |      |   |   | 25,000 |   |

| (1)   | Messrs. Allan, Maupay and Frankel no longer serve as members of the Board of Directors, effective upon the merger with Pathfinder, LLC in September 2011. |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------|

| Name of Beneficial Owner or Number in Group                 | Shares of Common Stock Beneficially Owned (1) | Percent of Class |
|-------------------------------------------------------------|-----------------------------------------------|------------------|
|                                                        |                                          |             |
| Breisgau Bio Ventures S.A.                                  | 255,825,263 (2)                               | 38.3             |
| GU Holdings Limited                                         | 63,524,929 (3)                                | 9.5              |
| Richard L. Franklin                                         | 46,681,781 (4)                                | 7.0              |
| Joerg Gruber                                                | 58,496,699 (5)                                | 8.7              |
| Paul Shiels (6)                                             | 38,114,957                                    | 5.7              |
| John Benson                                                 | 888,333 (7)                                   | *                |
| Brock Reeve                                                 | 602,636 (8)                                   | *                |
| John Brooks                                                 | 602,636 (8)                                   | *                |
| Zen Chu                                                     | 602,636 (8)                                   | *                |
| John Alam                                                   | 602,636 (8)                                   | *                |
| Robert Hickey                                               | 1,675,500 (9)                                 | *                |
| Eli Pines                                                   | 2,392,783 (10)                                | *                |
| All executive officers and directors as a group (7 persons) | 108,477,357 (11)                              | 15.9             |

----

----

----

|   Plan Category     | Number of securities to be               | Weighted average exercise     | Number of securities    |
|-------------------------------|------------------------------------------|-------------------------------|-------------------------|
|                          | issued upon exercise of                  | price of outstanding options, | remaining available for |
|                          | outstanding options, warrants and rights | warrants and rights           | future issuance         |
| Equity compensation plans     |                                     |                          |                    |
| approved by security holders  | 21,047,000(1)                            | $0.15                         | 3,280,000               |
| Equity compensation plans not |                                     |                          |                    |
| approved by security holders  | 2,779,000                                | $0.45                         | 0                       |
|                          |                                     |                          |                    |
| Total                         | 23,826,000                               | $0.19                         | 3,280,000               |

|   | (1) | Includes an aggregate of 14,061,410 shares of common stock underlying stock options assumed in connection with the merger with Pathfinder, LLC and replaced with stock options under the Company’s 2006 Stock Option Plan.  The weighted average exercise price of such stock options is $.05 per share. |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

----

|               |   | 2011   |    |   | 2010   |   |
|--------------------|--------|--------|---------|--------|--------|--------|
| Audit Fees         |   | $      | 117,200 |   |   | $      | 77,100 |   |
| Audit-related Fees |   |   | -       |   |   |   | - |   |
| Tax Fees           |   |   | -       |   |   |   | - |   |
| Other Fees    |   |   | -       |   |   |   | - |   |

|                           |   | 2010   |   |
|--------------------------------|--------|--------|--------|
| Audit Fees                     |   | $      | 30,042 |   |
| Audit-related Fees   |   |   | -      |   |
| Tax Fees                  |   |   | -      |   |
| Other Fees                     |   |   | -      |   |

----

| 2.1    | Agreement and Plan of Merger, dated as of December 22, 2010, by and among Registrant, SYMD Acquisition Sub, Inc., a wholly-owned subsidiary of Registrant, and Pathfinder, LLC, as amended.  (Incorporated by reference to Annex A of the definitive proxy statement on Schedule 14A filed by Registrant with the Securities and Exchange Commission on July 26, 2011.) |
|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 3.1    | Restated Certificate of Incorporation of Registrant, filed December 26, 1991, as amended. (Incorporated by reference to the Registrant’s Registration Statement on Form S-1 (Reg. No. 33-94008) declared effective on September 22, 1992.)                                                                                                                                  |
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 3.1(a) | Amendment to Restated Certificate of Incorporation, dated August 21, 1992. (Incorporated by reference to the Registrant’s Registration Statement on Form S-1 (Reg. No. 33-94008) declared effective on September 22, 1992.)                                                                                                                                                 |
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 3.1(b) | Amendment to Restated Certificate of Incorporation, dated April 22, 2005. (Incorporated by reference to the Registrant’s report on Form 10-KSB for the year ended December 31, 2006.)                                                                                                                                                                                       |
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 3.1(c) | Amendment to Restated Certificate of Incorporation, dated April 27, 2006. (Incorporated by reference to the Registrant’s report on Form 10-QSB for the quarter ended March 31, 2006.)                                                                                                                                                                                       |
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 3.1(d) | Amendment to the Restated Certificate of Incorporation of Registrant, as filed with the State of Delaware on September 1, 2011.  (Incorporated by reference to the Registrant’s report on Form 8-K filed September 9, 2011).                                                                                                                                      |
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 3.2    | By-Laws of Registrant. (Incorporated by reference to the Registrant’s Registration Statement on Form S-1 (Reg. No. 33-94008) declared effective on September 22, 1992.)                                                                                                                                                                                                     |
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 3.2(a) | Amendment to By-Laws of Registrant, adopted September 29, 2011.(1)                                                                                                                                                                                                                                                                                                                |
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 3.3    | Certificate of Designations of Series D Junior Participating Preferred Stock of the Registrant. (Incorporated by reference to the Registrant’s report on Form 8-K filed in May 2008.)                                                                                                                                                                                       |
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 3.4    | Certificate of Elimination of Series A Convertible Preferred Stock, Series B Convertible Preferred Stock  and Series C Convertible Preferred Stock. (Incorporated by reference to the Registrant’s report on Form 8-K filed in May 2008.)                                                                                                                         |
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 10.1   | The Registrant’s 2000 Stock Option Plan. (Incorporated by reference to the Registrant’s report on Form 8-K filed in May 2008.)                                                                                                                                                                                                                                        |
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 10.2   | Agreement, dated December 1, 2011, between Registrant and Yissum Research Development Company of the Hebrew University of Jerusalem. (1)                                                                                                                                                                                                                                          |
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 10.3   | Form of Indemnification Agreement entered into between Registrant and certain officers and directors of Registrant. (Incorporated by reference to Registrant’s Registration Statement on Form S-1 (Reg. No. 333-02588) declared effective on May 3, 1996.)                                                                                                                  |
|   |                                                                                                                                                                                                                                                                                                                                                                              |
| 10.4   | 2001 Non-Qualified Stock Option Plan including form of Stock Option Agreement. (Incorporated by reference to the Registrant’s report on Form 10-K for the year ended December 31, 2001.)                                                                                                                                                                                    |

| 10.5    | Consulting Agreement dated October 1, 2008 between the Registrant and Richard L. Franklin, MD. (Incorporated by reference to the Registrant’s report on Form 10-Q for the quarter ended September 30, 2008.) (2)                                                                                                                                                            |
|---------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    |                                                                                                                                                                                                                                                                                                                                                                              |
| 10.5(a) | Compensation arrangement with Dr. Richard L. Franklin, MD. (Incorporated by reference to Item 5.02(c) of the Registrant’s report on Form 8-K filed with the Securities and Exchange Commission on September 9, 2011.)(2)                                                                                                                                               |
|    |                                                                                                                                                                                                                                                                                                                                                                              |
| 10.6    | The Registrant’s 2006 Stock Option Plan, as amended. (1)                                                                                                                                                                                                                                                                                                                    |
|    |                                                                                                                                                                                                                                                                                                                                                                              |
| 10.7    | Form of ISO and Non-Qualified Stock Option Agreements under the Registrant’s 2006 Stock Option Plan. (Incorporated by reference to the Registrant’s report on Form 10-KSB for the year ended December 31, 2006.)                                                                                                                                                      |
|    |                                                                                                                                                                                                                                                                                                                                                                              |
| 10.8    | Supply Agreement, dated as of June 12, 2007, between our company and Diagnostic Chemicals Limited, doing business as BioVectra (portions of this exhibit have been redacted and filed separately with the SEC pursuant to a request for confidential treatment). (Incorporated by reference to the Registrant’s report on Form 10-QSB for the quarter ended June 30, 2007.) |

----

|     |                                                                                                                                                                                                                                                                                                                                                            |
|----------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 10.9     | Supply Agreement, dated as of March 29, 2007, between our company and Chem Development Inc. (Portions of this exhibit have been omitted  and filed separately with the SEC pursuant to a request for confidential treatment).  (Incorporated by reference to the Registrant’s report on Form 10-QSB for the quarter ended March 31, 2007.) |
|     |                                                                                                                                                                                                                                                                                                                                                            |
| 10.10    | Supply Agreement, dated as of March 18, 2007, between our company and Surgical Technologies Inc. (portions of this exhibit have been omitted  and filed separately with the SEC pursuant to a request for confidential treatment). (Incorporated by reference to the Registrant’s report on Form 10-QSB for the quarter ended March 31, 2007.)       |
|     |                                                                                                                                                                                                                                                                                                                                                            |
| 10.11    | Revolving Credit and Security Agreement dated September 14, 2010 between Registrant and Pathfinder, LLC. (Incorporated by reference to the Registrant’s report on Form 10-Q for the quarter ended September 30, 2010.)                                                                                                                                    |
|     |                                                                                                                                                                                                                                                                                                                                                            |
| 10.11(a) | Amendment No. 1 dated February 15, 2011 to Revolving Credit and Security Agreement between Registrant and Pathfinder, LLC. (Incorporated by reference to Registrant’s Annual Report on Form 10-K for the year ended December 31, 2010 filed with the Securities and Exchange Commission on March 25, 2011.)                                               |
|     |                                                                                                                                                                                                                                                                                                                                                            |
| 10.11(b) | Amendment No. 2 dated April 14, 2011 to Revolving Credit and Security Agreement between Registrant and Pathfinder, LLC. (Incorporated by reference to Amendment No. 1 to Registrant’s Annual Report on Form 10-K/A for the year ended December 31, 2010 filed with the Securities and Exchange Commission on May 2, 2011.)                                |
|     |                                                                                                                                                                                                                                                                                                                                                            |
| 10.12    | Termination Agreement dated November 29, 2010 between Registrant and Robert P. Hickey.  (Incorporated by reference to Registrant’s Annual Report on Form 10-K for the year ended December 31, 2010 filed with the Securities and Exchange Commission on March 25, 2011.)                                                                        |
|     |                                                                                                                                                                                                                                                                                                                                                            |
| 10.13    | Termination Agreement dated November 29, 2010 between Registrant and Dr. Eli Pines. (Incorporated by reference to Registrant’s Annual Report on Form 10-K for the year ended December 31, 2010 filed with the Securities and Exchange Commission on March 25, 2011.)                                                                                      |
|     |                                                                                                                                                                                                                                                                                                                                                            |
| 10.14    | Banker Engagement Termination Agreement dated December 22, 2010 between Registrant and Oppenheimer & Co. (Incorporated by reference to Registrant’s Annual Report on Form 10-K for the year ended December 31, 2010 filed with the Securities and Exchange Commission on March 25, 2011.)                                                             |

| 10.15          | Research Agreement dated March 23, 2009 between The University Court of the University of Glasgow and Pathfinder, LLC. (Incorporated by reference to Registrant’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2011, filed with the Securities and Exchange Commission on November 21, 2011.)                                                                                      |
|----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 10.15(a)  | Extension No. 2 to Research Agreement dated March 23, 2009 between The University Court of the University of Glasgow and Pathfinder, LLC. (3)                                                                                                                                                                                                                                                            |
| 10.16          | License Agreement dated March 23, 2009 between The University Court of the University of Glasgow and Pathfinder, LLC. (Incorporated by reference to Registrant’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2011, filed with the Securities and Exchange Commission on November 21, 2011.)                                                                                            |
|           |                                                                                                                                                                                                                                                                                                                                                                                                               |
| 10.17          | Exclusive Patent License Agreement dated as of April 13, 2009 between The General Hospital Corporation d/b/a Massachusetts General Hospital and Pathfinder, LLC, including amendment No. 1 dated March 24, 2011. (Incorporated by reference to Registrant’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2011, filed with the Securities and Exchange Commission on November 21, 2011.) |
|           |                                                                                                                                                                                                                                                                                                                                                                                                               |
| 10.18          | Form of Subscription Agreement for investors in the 2011private placement. (Incorporated by reference to Registrant’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2011, filed with the Securities and Exchange Commission on November 21, 2011.)                                                                                                                                       |
|           |                                                                                                                                                                                                                                                                                                                                                                                                               |
| 10.19          | Agency Agreement dated August 31, 2011 between Registrant and Clubb Capital Limited, as placement agent. (Incorporated by reference to Registrant’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2011, filed with the Securities and Exchange Commission on November 21, 2011.)                                                                                                         |
|           |                                                                                                                                                                                                                                                                                                                                                                                                               |
| 10.20          | Form of broker warrant issued for an aggregate of 6,276,306 shares to Clubb Capital Limited or its designees in connection with the Capital Raise. (Incorporated by reference to Registrant’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2011, filed with the Securities and Exchange Commission on November 21, 2011.)                                                               |
|           |                                                                                                                                                                                                                                                                                                                                                                                                               |
| 10.21          | Promissory Note dated September 2, 2011 issued by Registrant to Clubb Capital Limited for the deferred portion of the placement agent commission. (Incorporated by reference to Registrant’s Quarterly Report on Form 10-Q for the quarter ended September 30, 2011, filed with the Securities and Exchange Commission on November 21, 2011.)                                                                |

----

|       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
|------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| 10.22      | Promissory Notes issued by Registrant in favor of Falcon Corporate Investments Limited in the aggregate principal amount of $720,000.(3)                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
|       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
| 10.23      | [omitted]                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
|       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
| 10.24      | Employment Agreement dated September 8, 2006, between the Registrant and John Benson.(1)(2)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
|       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
| 10.24(a)   | Compensation arrangement with John Benson.(1)(2)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
|       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
| 21         | List of subsidiaries. (1)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
|       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
| 23.1       | Consent of EisnerAmper LLP. (1)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |
|       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
| 31.1  | Certification of Principal Executive Officer Pursuant to Exchange Act Rule 13a-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. (3)                                                                                                                                                                                                                                                                                                                                                                                                                                                       |
|       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
| 31.2  | Certification of Principal Financial Officer Pursuant to Exchange Act Rule 13a-14(a), as adopted pursuant to Section 302 of the Sarbanes-Oxley Act of 2002. (3)                                                                                                                                                                                                                                                                                                                                                                                                                                                       |
|       |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
| 101        | Interactive data files pursuant to Rule 405 of Regulation S-T: (i) the Condensed Statements of Operations for the years ended December 31, 2011 and 2010 and the cumulative period from November 4, 2008 (inception) to December 31, 2011, (ii) the Condensed Consolidated Balance Sheets at December 31, 2011 and December 31, 2010, (iii) the Condensed Consolidated Statements of Cash Flows for the years ended December 31, 2011 and 2010 and the cumulative period from November 4, 2008 (inception) to December 31, 2011 and (iv) the Notes to the Condensed Consolidated Financial Statements.  (1) |

| (1)                   | Previously filed with the original filing of this Annual Report on Form 10-K on March 30, 2012. |
|---------------------------------|-------------------------------------------------------------------------------------------------|
| (2)   (3)   | Indicates a management contract or compensatory plan or arrangement.Filed herewith.             |

----

|                  | Pathfinder Cell Therapy, Inc. |                               |
|-----------------------|-------------------------------|------------------------------------|
|                  | (Registrant)                  |                               |
|                  |                          |                               |
|                  |                          |                               |   |
|                  | By:                           | /s/ Richard L. Franklin, M.D. |   |
|                  |                          | Richard L. Franklin, M.D.          |   |
|                  |                          | CEO and President                  |   |
| Dated: April 30, 2012 |                          |                               |   |

----