EPA REGISTRATION DIVISION COMPANY NOTICE OF FILING FOR PESTICIDE 

PETITIONS PUBLISHED IN THE FEDERAL REGISTER 

EPA Registration Division contact: P.V. Shah, 703-308-1846

TEMPLATE: 

Cognis Corporation

Pesticide Petition (PP) Number 9E7638

 EPA has received a pesticide petition (PP No. 9E7638) from Cognis Corporation (c/o 

Lewis & Harrison, LLC, 122 C Street NW, Suite 740, Washington DC 20001) proposing, 

pursuant to section 408(d) of the Federal Food, Drug, and Cosmetic Act (FFDCA), 21 U.S.C. 

346a(d), to amend 40 CFR part 180 by consolidating and moving (recodifying) existing tolerance 

exemptions for the alkyl polyglycosides (CAS Reg. Nos. 68515-73-1, 110615-47-9, and 132778-

08-6). Currently, there are three separate listings in 40 CFR §180.910 and §180.930 for the alkyl 

polyglycosides. This petition proposes to unify these separate listing into a single listing (Dglucopyranose, oligomeric C8-16 – alkyl glycosides) and move the new listing to §180.950.

 EPA has determined that the petition contains data or information regarding the 

elements set forth in Section 408(d)(2) of FFDCA; however, EPA has not fully evaluated the 

sufficiency of the submitted data at this time or whether the data supports granting of the 

petition. Additional data may be needed before EPA rules on the petition. 

A. Residue Chemistry

Residue data, including an analytical method, is not pertinent or required for this petition since 

the petition merely proposes to consolidate existing tolerances and move the unified tolerance to 

another section in the CFR. 

B. Toxicological Profile

An extensive safety data base has been complied on the alkyl polyglycosides. The safety data 

base includes acute, sub-chronic, developmental toxicity, mutagenicity and metabolism studies. 

1. Acute toxicity. 

The acute oral toxicity of the alkyl polyglycosides is greater than 5.0 g/kg-b.w indicating a low 

order of acute toxicity. At high concentrations, the alkyl polyglycosides can be irritating to eyes 

and skin. The alkyl polyglycosides are not dermal sensitizers. 

 

2. Genotoxicity. 

No evidence of genotoxicity or chromosomal effects were observed in mutagenicity studies 
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conducted with the alkyl polyglycosides. 

3. Reproductive and developmental toxicity. 

In a rat teratology study, no maternal or developmental effects were noted in any of the test 

groups. 

4. Subchronic toxicity. 

In a 90-day feeding study, the only treatment related effect was reversible dose-dependent 

irritation and ulceration of the mucous membranes of the forestomach. This effect only 

occurred at high-dose levels (500 and 1000 mg/kg-b.w.) that greatly exaggerates anticipated 

dietary intake. 

 5. Chronic toxicity.

There are no chronic/oncogencity studies available on the alkyl polyglycosides. 

 

6. Animal metabolism. 

Animal metabolism studies show that the alkyl polyglycosides are rapidly hydrolyzed into sugars 

and long-chain alcohols. 

7. Metabolite toxicology. 

There are no metabolites of toxicological concern. 

8. Endocrine disruption. 

Based on available studies, there is no information or evidence that the alkyl polyglycosides are 

endocrine disruptors. 

C. Aggregate Exposure

An aggregate exposure discussion is not applicable since this petition is not requesting any new 

food uses or a modification of existing tolerances.

D. Cumulative Effects

A cumulative effects discussion is not applicable since this petition is not requesting any new 

food uses or a modification of existing tolerances. 

E. Safety Determination

Cognis believes that moving the existing tolerance exemptions for the alkyl polyglycosides from 
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40 CFR §180.910 and §180.930 to §180.950 is supported by the available safety and metabolism 

data on these substances. 

As part of the tolerance reassessment process for the alkyl polyglycosides, the Agency reviewed 

the safety data base and concluded that the alkyl polyglycosides are lower toxicity substances. 

The safety test data clearly shows that the alkyl polyglycosides, except for localized irritation at 

high concentrations, are practically non-toxic after both acute and repeated exposures. The one 

effect that was observed in the sub-chronic study – irritation of the forestomach – is typical of 

surfactants, such as the soap salts, which are listed in §180.950. In terms of meeting the minimal 

risk characteristic of §180.950, Cognis believes that the safety and metabolism data on the alkyl 

polyglycosides are similar to some of the ingredients currently listed in this section. In 

particular, the alkyl polyglycosides have a similar safety profile when compared to the lactic acid 

esters and soap salts. 

F. International Tolerances

There are no CODEX MRLs established for the alkyl polyglycosides.