Initial to indicate certification as to information on this page (full text of certification is on page one) 

13. Phone Number

10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any 

knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.

12. Name of Company

11. Date

OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

MCLAUGHLIN GORMLEY KING COMPANY

8810 TENTH AVE NORTH

MINNEAPOLIS, MN 554274319

Environmental Fate Data Requirements (Conventional 

Chemical)

Terrestrial and Aquatic Nontarget Organisms Data 

Requirements (Conventional Chemical)

835.6100

850.1010

850.1025

835.1230

835.1240

835.2120

Terrestrial field dissipation

Aquatic invertebrate acute toxicity, test, freshwater 

daphnids

Oyster acute toxicity test (shell deposition)

Sediment and soil absorption/desorption for parent 

and degradates

Soil column leaching

Hydrolysis of parent and degradates as a function of 

pH at 25 C

3128 - Sabadilla alkaloids

Chemical # and Name: 002201

Sabadilla alkaloids

GENERIC

ID # GDCI-002201-1577

B,A

B,A

B,A

B,A

B,A

B,A

TEP

TGAI

TGAI

COMMENT

COMMENT

COMMENT

12

12

12

12

12

12

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N

N

N

N

N

7
OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

MCLAUGHLIN GORMLEY KING COMPANY

8810 TENTH AVE NORTH

MINNEAPOLIS, MN 554274319

835.2240

835.2410

835.4100

835.4300

835.4400

850.1035

850.1075

850.1300

850.1350

Direct photolysis rate of parent and degradates in 

water

Photodegradation of parent and degradates in soil

Aerobic soil metabolism

Aerobic aquatic metabolism

Anaerobic aquatic metabolism

Mysid acute toxicity test

Fish acute toxicity test, freshwater and marine

Daphnid chronic toxicity test

Mysid chronic toxicity test

3128 - Sabadilla alkaloids

Chemical # and Name: 002201

Sabadilla alkaloids

GENERIC

ID # GDCI-002201-1577

B,A

B,A

B,A

B,A

B,A

B,A

B,A

B,A

B,A

COMMENT

COMMENT

COMMENT

COMMENT

COMMENT

TGAI

TGAI

TGAI

TGAI

12

12

24

24

12

12

12

12

12

Page 2 of 

(28)

(28)

(11)

(11)

(28)

(6)

(13)

(24)

(7)

N

N

N

N

N

N

N

N

N

7
OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

MCLAUGHLIN GORMLEY KING COMPANY

8810 TENTH AVE NORTH

MINNEAPOLIS, MN 554274319

850.1400

850.1730

850.1735

850.1740

850.2100

850.2200

850.2300

850.3040

850.4100

850.4150

Fish early-life stage toxicity test

Fish BCF

Whole sediment: acute freshwater invertebrates

Whole sediment: acute marine invertebrates

Avian acute oral toxicity test

Avian dietary toxicity test

Avian reproduction test

Field testing for pollinators

Seedling Emergence and Seedling Growth

Vegetative Vigor

3128 - Sabadilla alkaloids

Chemical # and Name: 002201

Sabadilla alkaloids

GENERIC

ID # GDCI-002201-1577

B,A

B,A

B,A

B,A

B,A

B,A

B,A

B,A

B,A

B,A

TGAI

COMMENT

TGAI

TGAI

TGAI

TGAI

TGAI

TEP

TEP

TEP

12

12

12

12

12

12

24

24

12

12

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(4, 36)

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(15)

(1, 23)

(27)

(9)

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N

N

N

N

N

N

N

N

7
OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

MCLAUGHLIN GORMLEY KING COMPANY

8810 TENTH AVE NORTH

MINNEAPOLIS, MN 554274319

850.4400

850.4500

850.4550

850.6100

860.1100

860.1300

860.1340

860.1360

860.1380

Aquatic Plant Toxicity Using Lemna spp

Algal Toxicity

Cyanobacteria (Anabaena flos-aquae) Toxicity

Environmental Chemistry Methods and Associated 

Independent Laboratory Validation

Chemical identity

Nature of the residue - plants, livestock

Residue analytical method

Multiresidue method

Storage stability data

3128 - Sabadilla alkaloids

Chemical # and Name: 002201

Sabadilla alkaloids

GENERIC

ID # GDCI-002201-1577

B,A

B,A

B,A

B,A

B,A

B,A

B,A

B,A

B,A

TGAI

TGAI

TGAI

TGAI

TGAI

TGAI

Residue of Concern

Residue of Concern

Residue of Concern

12

12

12

24

6

24

24

24

24

Page 4 of 

(26)

(17)

(8)

(25, 40)

(21)

N

N

N

N

N

N

N

N

N

7
OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

MCLAUGHLIN GORMLEY KING COMPANY

8810 TENTH AVE NORTH

MINNEAPOLIS, MN 554274319

860.1480

860.1500

860.1520

860.1650

860.1850

860.1900

870.3150

870.3200

870.3465

870.3700

Meat/milk/poultry/eggs

Crop field trials (CROP, IRRIGATED) 

Processed food/feed (CITRUS) 

Submittal of analytical reference standards

Confined accumulation in rotational crops

Field accumulation in rotational crops

90-day oral toxicity in nonrodents

21/28-day dermal toxicity

90-day inhalation toxicity

Prenatal developmental toxicity study

3128 - Sabadilla alkaloids

Chemical # and Name: 002201

Sabadilla alkaloids

GENERIC

ID # GDCI-002201-1577

B,A

B,A

B,A

B,A

B,A

B,A

B,A

B,A

B,A

B,A

TGAI

TEP

TEP

TGAI

TEP

TEP

TGAI

TGAI

TGAI

TGAI

24

24

24

12

24

24

24

24

24

24

Page 5 of 

(43)

N

N

N

N

N

N

N

N

N

N

7
OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

MCLAUGHLIN GORMLEY KING COMPANY

8810 TENTH AVE NORTH

MINNEAPOLIS, MN 554274319

870.3800

870.4200

870.6200

870.7485

870.7800

875.2000

875.2100

SS-1256

SS-1257

Reproduction and fertility effects

Carcinogenicity

Neurotoxicity screening battery

Metabolism and pharmacokinetics

Immunotoxicity

Background for postapplication exposure monitoring 

test guidelines

Foliar dislodgeable residue dissipation

Acute oral toxicity--honeybee adult

Acute oral toxicity--honeybee larvae

3128 - Sabadilla alkaloids

Chemical # and Name: 002201

Sabadilla alkaloids

GENERIC

ID # GDCI-002201-1577

B,A

B,A

B,A

B,A

B,A

B,A

B,A

B,A

B,A

TGAI

TGAI

TGAI

TGAI

TGAI

TGAI

TGAI

TGAI

TGAI

48

48

12

24

12

24

24

12

12

Page 6 of 

(20)

(42)

(30, 32)

(24, 34, 44)

N

N

N

N

N

N

N

Y

Y

7
Date

OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

MCLAUGHLIN GORMLEY KING COMPANY

8810 TENTH AVE NORTH

MINNEAPOLIS, MN 554274319

SS-1315

SS-1344

SS-1346

SS-1353

SS-WholeSedIn

Semi-field testing for pollinators 

Chronic Oral Toxicity - Larval Honeybee

Chronic Oral Toxicity - Adult Honeybee

Residues in pollen and nectar

Whole sediment: Chronic invertebrates (freshwater & 

marine)

3128 - Sabadilla alkaloids

Chemical # and Name: 002201

Sabadilla alkaloids

GENERIC

ID # GDCI-002201-1577

B,A

B,A

B,A

B,A

B,A

TEP

TGAI

TGAI

TEP

TGAI

24

12

12

24

24

Page 7 of 

(22, 44)

(34, 44)

(30, 33, 44)

(10, 35, 44)

(18, 29, 44)

Y

Y

Y

Y

Y

7
United States Environmental Protection Agency 

Washington, D.C. 20460

FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS

3128 - Sabadilla alkaloids

GDCI-002201-1577

1

2

3

4

5

6

7

8

9

10

11

12

13

14

15

16

17

Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active 

Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Tier III: Test material is Sabadilla alkaloids TEP.

Tier II: Test with Sabadilla alkaloids; this study will be needed if KOC values are analytically confirmed to be consistent with those predicted by EPISuite.

Tier II: Test with Sabadilla alkaloids; the need for these data will be determined based on the results from the (Tier I) testing under OCSPP Guideline #850.1300. Preferred test species is eastern 

oyster.

Tier II: Test with Sabadilla alkaloids. This study will be needed if KOC values are analytically confirmed to be consistent with those predicted by EPISuite. The requirement is for a 10-day 

subchronic study.

Tier II: Test substance is Sabadilla alkaloids. Bobwhite quail and mallard duck are the preferred test species. The need for Tier II data is dependent on the results of Tier I testing (OCSPP 

Guideline 850.2100 Avian Acute Oral Toxicity with bobwhite quail and OCSPP Guideline 850.2300 Avian Reproduction with bobwhite quail).

Tier II: Test material is Sabadilla alkaloids. The need for these data is pending based on the results of the Tier I test (OCSPP Guideline 850.1300). Mysid shrimp is the preferred test species.

Tier II: Test with Sabadilla alkaloids. The need for Tier II data is dependent on the results of the Tier I testing under OCSPP Guideline #850.1300.

Tier II: Test substance is sabadilla alkaloids; test species is Anabaena flos-aquae. The need for Tier II testing is dependent on the results of Tier I testing under OCSPP Guidelines 850.4400 

Aquatic Vascular Plant Toxicity Test with Lemna spp., and 850.4500 Algal Toxicity with Pseudokirchneriella subcapitata.

Tier II: Test substance is Sabadilla alkaloids TEP. The need for Tier II testing is dependent on the results of testing under OCSPP Guideline 850.4100.

Tier II: Test material is Sabadilla alkaloids.

Tier I: Test with veratridine; Tier II:Test with cevadine. The need for Tier II testing is dependent on the results of Tier I testing under this guideline.

Tier I: Test with Sabadilla alkaloids, freshwater fish, cold water species. 

Tier II: Test with Sabadilla alkaloids, freshwater fish, warm water species, and estuarine/marine species. The need for the Tier II studies is dependent on the results of the Tier 1 study for this 

guideline (OCSPP 850.1400).

Tier I: Test with Sabadilla alkaloids, 1 freshwater fish (cold water species) Tier II: Test with Sabadilla alkaloids, 1 freshwater fish (warm water species) and 1 estuarine/marine species. The 

need for Tier II testing is dependent on the results of Tier I testing under this guideline.

Tier I: Test substance is Sabadilla alkaloids; the preferred test species is bobwhite quail. Tier II: Test substance is Sabadilla alkaloids; the preferred test species are mallard duck and a 

passerine species. The need for the Tier II data is dependent on the results of the Tier I study under this Guideline.

Tier I: Test substance is Sabadilla alkaloids; bobwhite quail is the preferred test species. Tier II: Test substance is Sabadilla alkaloids; mallard duck is the preferred test species. The need for 

Tier II data is dependent on the results of Tier I testing (OCSPP Guidelines 850.2100 Avian Acute Oral Toxicity with bobwhite quail, and 850.2300 Avian Reproduction with bobwhite quail).

Tier I: Test material is veratridine; Tier II: Test material is cevadine. The need for Tier II testing is dependent on the results of Tier I testing under this guideline.

Tier I testing: Test material is sabadilla alkaloids; test species is Pseudokirchneriella subcapitata. Tier II testing: Test material is sabadilla alkaloids; test species are Skeletonema costatum and 

Case # and Name:

DCI Number:

Page: 1 of

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. 

These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement.

Use Categories Key:

A - Terrestrial food crop

B - Terrestrial feed crop

4
United States Environmental Protection Agency 

Washington, D.C. 20460

FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS

3128 - Sabadilla alkaloids

GDCI-002201-1577

18

19

20

21

22

23

24

25

26

27

28

29

30

31

32

33

Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active 

Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Navicula pelliculosa. The need for Tier II testing is dependent on the results of the Tier I studies under OCSPP Guidelines 850.4400 Aquatic Vascular Plant Toxicity Test with Lemna spp., and 

850.4500 Algal Toxicity with Pseudokirchneriella subcapitata

This DCI includes both Tier I and Tier II components for some environmental fate and ecological toxicity data requirements. For this study and all others with higher tier components, the need for 

the higher tier data will be determined based on the results of the lower tier testing.

The test substance is veratridine.

The preferred test species is rat.

The preferred test species for plants are selected to represent the registered use sites. The registrant should meet with the Agency to discuss test species prior to initiating the study. The 

preferred test species in livestock are lactating goat and laying hen.

The need for a field or a semi-field test for pollinators (i.e., either a field-feeding test or a tunnel test) will be determined based upon lower-tiered tests and/or other lines of evidence, and the 

need for a refined pollinator risk assessment--Sabadilla Tier II Data Requirement.

Formal guidelines for semi-field tests do not yet exist; however, information that can help guide the development of either a semi-field tunnel test protocol can be found at OECD 75, see: OECD. 

2007. Series on Testing and Assessment Number 75. Guidance document on the honey bee (Apis mellifera L.) brood test under semi-field conditions. Environmental Directorate Joint Meeting of 

the Chemicals Committee and the Working Party on Chemicals, Pesticides and Biotechnology. ENV/JM/MONO(2007)22. 31-Aug-2007. 

http://www.oecd.org/officialdocuments/publicdisplaydocumentpdf/?cote=env/jm/mono(2007)22&doclanguage=en. 

For field-feeding studies see: Oomen et al. 1992: Oomen, P. A. A. DeRuijter and J. Van der Steen. 1992. Method for honey bee brood feeding tests with insect growth-regulating insecticides. 

Bul OEPP/EPPO Bulletin 22: 613 ¿ 616.

The need for a field or a semi-field test for pollinators (i.e., either a field-feeding test or a tunnel test) will be determined based upon lower-tiered pollinator tests and/or other lines of evidence, 

and the need for a refined pollinator risk assessment.

Test with Sabadilla alkaloids

Test substance is veratridine.

Test substance is Sabadilla alkaloids.

Test substance is Sabadilla alkaloids TEP.

Test material is veratridine.

Test material is sabadilla alkaloids for this Tier II study. Test organism should be the most sensitive species identified from the subchronic studies (850.1735 and 850.1740).

Test material is Sabadilla alkaloids.

Test material is Sabadilla alkaloids TEP.

See the OECD 213: OECD Guidelines for the Testing of Chemicals. Honeybees, Acute Oral Toxicity Test. 213. http://lysander.sourceoecd.org/vl=5988235/cl=12/nw=1/rpsv/cgibin/fulltextew.pl?prpsv=/ij/oecdjournals/1607310x/v1n2/s14/p1.idx

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

OECD has not yet finalized test guidelines for chronic studies, and efforts are underway to develop standardized guidelines for assessing the effects from chronic exposure to adult and larvae 

in the laboratory. Discussion of the study design elements for the 10-day adult toxicity test can be found in Appendix O of the European Food Safety Authority (EFSA) guidance document:

EFSA. Guidance on the risk assessment of plant protection products on bees (Apis mellifera, Bombus spp. and solitary bees. EFSA Journal 2013; 11(7):3295, 266 pp. 

Case # and Name:

DCI Number:

Page: 2 of 4
United States Environmental Protection Agency 

Washington, D.C. 20460

FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS

3128 - Sabadilla alkaloids

GDCI-002201-1577

34

35

36

37

38

39

40

41

42

43

Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active 

Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

doi:10.2903/j.efsa.2013.3295. Available online at: http://www.efsa.europa.eu/en/efsajournal/doc/3295.pdf.

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

OECD has not yet finalized test guidelines for chronic studies with honey bee larvae. OECD draft guidance is being developed, see OECD 2013b. OECD Draft Guidance Document Honey Bee 

(Apis mellifera) Larval Toxicity Test, Repeated Exposure. http://www.oecd.org/env/ehs/testing/Draft_GD_honeybees_rep_exp_for_2nd_CR_25_November_2013.pdf. 

In some cases, information pertaining to acute toxicity to honey bee larvae may be obtained with the chronic honey bee larvae test thereby negating the need for separate acute and chronic 

larval toxicity tests.

Measurements of residues in the pollen/nectar are needed based upon lower-tiered tests and/or other lines of evidence, and the need for a refined pollinator risk assessment.

The following elements should be considered when developing study protocol(s) for the monitoring of residues in pollen/nectar.

The range of application methods and environmental conditions (e.g., soil and hydric regimes) that the target crop(s) may be under.

The attractiveness of the selected crop to pollinators

A collection schedule sufficient to allow for an understanding of the character of residues, in the pollen/nectar and/or plant tissues, over time.

Whether residues of the active ingredient and/or degradation product(s) accumulate in soil and are bioavailable for plant to uptake in a following planting, and could result in potential exposure to

pollinators.

Market proportion of the selected target crop(s).

For field-feeding studies see: Oomen et al. 1992: Oomen, P. A. A. DeRuijter and J. Van der Steen. 1992. Method for honey bee brood feeding tests with insect growth-regulating insecticides. Bul

OEPP/EPPO Bulletin 22: 613-616.

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

Leptocheirus plumulosus is the preferred test species. This requirement is for a sub-chronic test.

Hyalella Azteca and Chironomus dilutes are the preferred test species. This requirement is for a 10-day subchronic test.

For all studies in which the test material is the sabadilla alkaloids TGAI, TGAI refers to a mixture of sabadilla alkaloids that would be representative of the active ingredient found in the registered 

product. It has been reported that there is significant variation in the concentrations of individual components of the active ingredient in the finished product. All studies to be conducted with 

sabadilla alkaloid TGAI should conducted with material containing the same relative proportions of veratridine, cevadine, sabadinine, and sabadine in the mixture. Analytical confirmation of the 

concentration of each component (veratridine, cevadine, sabadinine, and sabadine) and confirmatory analysis that demonstrates that the sabadilla alkaloids TGAI used for testing is 

representative of the composition of sabadilla alkaloids contained in Veratran D for all studies using TGAI as the test material.

Environmental chemistry methods used to generate data associated with this study must include results of a successful confirmatory method trial by an independent laboratory. The 

environmental chemistry methods must include a statement of no data confidentiality claims, i.e., the study results will not be considered to be CBI.

ECM and ILV are needed for both soil and water.

Daphnia magna is preferred test species.

Carcinogenicity testing in the mouse and Combined Chronic/Carcinogenicity testing in the rat

Based on estimates of the magnitude and duration of human exposure, studies of shorter duration, i.e., 21- or 28-days, may be sufficient to satisfy this requirement. Registrant should consult 

with the Agency prior to initiation to determine whether studies of shorter duration would satisfy the requirement in this case.

Case # and Name:

DCI Number:

Page: 3 of 4
United States Environmental Protection Agency 

Washington, D.C. 20460

FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS

3128 - Sabadilla alkaloids

GDCI-002201-1577

44

Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active 

Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

Case # and Name:

DCI Number:

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