Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

PC Code: 128721

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF

CHEMICAL SAFETY AND

POLLUTION PREVENTION

MEMORANDUM

Date: 03/11/2013

SUBJECT: Halosulfuron-methyl. Acute and Chronic Aggregate Dietary (Food and Drinking 

Water) Exposure and Risk Assessments for the Section 3 Registration Action on 

Artichoke and Caneberry Subgroup 13-07A.

PC Code: 128721 DP Barcode: D405660

Decision No.: 465913 Registration Nos.: 81880-18 and 81880-2

Petition No.: 2E8050 Regulatory Action: Section 3 Registration

Risk Assessment Type: Dietary Case No.: NA

TXR No.: NA CAS No.: 100784-20-1

MRID No.: NA 40 CFR: §180.479

FROM: Meheret Negussie, Chemist

Risk Assessment Branch III

Health Effects Division (7509P)

THROUGH: Donna Davis, Chemist

Ideliz Negron-Encarnacion Ph.D., Chemist 

Dietary Exposure Science Advisory Council (DESAC)

Health Effects Division (HED; 7509P)

TO: Christine Olinger, Branch Chief

Sheila Healy, Ph.D., Toxicologist/Risk Assessor

HED/RAB3 (7509P)

and

Barbara Madden/Sydney Jackson (RM Team 03)

Risk Integration Minor Use, and Emergency Response Branch

Registration Division (7505P)
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

PC Code: 128721

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Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk assessments

were conducted using the Dietary Exposure Evaluation Model software with the Food 

Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food 

consumption data from the U.S. Department of Agriculture’s (USDA’s) National Health and 

Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). The analyses

were conducted to support a human health risk assessment for the proposed Section 3 requests on 

artichoke and caneberry Subgroup 13-07A. This memorandum was reviewed by two peer 

reviewers of the DESAC, per DESAC SOP 2012.1. 

 

Acute and Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

Acute and chronic dietary (food and drinking water) exposure assessments were conducted for 

the current uses, and proposed new uses on artichoke and caneberry Subgroup 13-07A. The 

assumptions of the dietary assessments included tolerance-level residues for all commodities and 

100 % crop treated (CT) for all crops. DEEM version 7.81 default processing factors were 

assumed except for where tolerances were established for processed commodities or when 

processing studies showed no concentration. Modeled estimated drinking water concentrations 

were included in the assessment

There was no indication of an adverse effect attributable to a single dose for the general U.S. 

population. However, an acute reference dose (aRfD) was established for females 13-49 years 

old, and an acute dietary exposure assessment was only conducted for females 13-49 years old. 

The acute dietary exposure estimate at the 95th percentile is <1% of the acute population adjusted 

dose (aPAD) for females 13-49 years old.

The chronic dietary (food and drinking water) exposure to halosulfuron-methyl is below HED’s 

level of concern (<100% of the chronic population adjusted dose (cPAD)) for the general U.S. 

population and all population subgroups. The chronic dietary exposure estimates are 2.0% of the 

cPAD for the general U.S. population and 5.5% of the cPAD for children 1-2 year old, the most 

highly exposed population subgroup.

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

Halosulfuron-methyl is classified as “not likely to be a human carcinogen;” therefore, 

quantification of human cancer risk is not required.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the 
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

PC Code: 128721

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point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References which discuss the acute and chronic risk assessments in more detail 

are available on the EPA/pesticides web site: “Available Information on Assessing Exposure 

from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for halosulfuron-methyl was conducted by Cassi Walls 

(D396459, 07/12/2012).

II. Residue Information

The Interregional Research Project No. 4 (IR-4) has proposed new uses of halosulfuron-methyl 

on artichoke and caneberry Subgroup 13-07A. Permanent tolerances are established under 

§180.479(a)(1) for residues of halosulfuron-methyl and its metabolites determined as 3-chloro-1-

methyl-5-sulfamoylpyrazole-4-carboxylic acid, expressed as halosulfuron-methyl equivalents, at 

levels ranging from 0.05 ppm (milk, fat and meat) to 1.0 ppm (meat byproducts ) of cattle, goat, 

hog, horse, and sheep at 0.1 ppm. Tolerances are established under §180.479(a)(2) for residues 

of halosulfuron-methyl in/on a variety of field, fruit, and vegetable crop commodities at levels 

ranging from 0.05 to 2.0 ppm. 

The Metabolism Committee has concluded that the residue of concern for tolerance enforcement 

and risk assessment in target plants and rotational plants is halosulfuron-methyl (G. J. Herndon, 

No DP#s, 9/16/1993 and 5/21/1996). 

HED previously has concluded that the residue of concern in ruminants is halosulfuron-methyl. 

However, because the approved enforcement method for livestock commodities quantifies the 

parent compound and metabolites containing the 3-CSA moiety by converting residues to 3-

CSA, tolerances for residues of parent and its metabolites in livestock commodities are 

determined as 3-CSA, expressed in halosulfuron-methyl equivalents. 

The residue of concern in water is halosulfuron-methyl. 

Residue Data used for Acute and Chronic Assessments:

These acute and chronic assessments are unrefined assessments using tolerance-level residues 

and 100% CT for all commodities. Additionally, DEEM version 7.81 default processing factors 

were assumed except for where tolerances were established for processed commodities or when 

processing studies showed no concentration. Based on processing studies, the processing factors 

for tomato paste, tomato puree, potato flour and potato granules/flakes were reduced to 1. 
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

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Table 1 is a summary of the HED recommended food tolerances resulting from the proposed 

uses (D405659, L. Cheng, 11/26/2012).

Table 1. Tolerance Summary for the New Uses for Halosulfuron-Methyl.

Commodity Recommended Tolerances

Used in the 

Acute and Chronic Analyses

(ppm)

Artichoke 0.05

Caneberry Subgroup 13-07A 0.05

III. Drinking Water Data (We didn’t receive the water memo, but EFED communicated 

(email) that there is no change. 

The drinking water residues used in the acute dietary risk assessment were provided by EFED in 

the following memorandum: “Halosulfuron methyl Drinking Water Assessment for Additional 

Food/Feed Uses on Proso Millet, Pasture and Rangeland Grass Forage, Fodder and Hay (Crop 

Group 17)” (D394244, J. Meléndez, 5/15/2012) and incorporated directly into this dietary

assessment. Water residues were incorporated in the DEEM-FCID into the food categories 

“water, direct, all sources” and “water, indirect, all sources.” Since the application rates 

associated with the proposed new uses did not exceed the application rate on rice (0.125 lb ai/A), 

a new acute drinking water assessment was not required for the acute dietary assessment 

(personal communication via email from Jose Melendez to Meheret Neghussie, date). 

Monitoring data is not available for halosulfuron-methyl; therefore estimated drinking water 

concentrations (EDWCs) were derived from models. 

Acute Tier I EDWCs for halosulfuron-methyl were based on a maximum annual application rate 

of 0.125 lb ai/A for rice. The two screening models, FIRST and Screening Concentrations in 

Ground Water (SCI-GROW), were used for estimating EDWCs of halosulfuron-methyl. 

Estimates for halosulfuron-methyl in surface water based on the FIRST model for rice are 59.2

ppb for acute and chronic concentrations. This value was used for the acute dietary assessment 

only. HED notes that this drinking water value is considered to be highly conservative and 

reflects a calculated concentration of residue in a shallow farm pond based on the maximum 

application rate on the label. HED considers this value appropriate as a screening level 

assessment for potential acute exposure and since the calculated concentration does not pose a 

risk of concern, further refinement is not required. 

 

The estimate for halosulfuron-methyl in groundwater based on the SCI-GROW model result is 

0.065 ppb. Table 2 summarizes the results.
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

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Table 2. Summary of Estimated Surface Water and Groundwater Concentrations for Halosulfuron-methyl.

Surface Water Conc., ppb a Groundwater Conc., ppb b

Acute 59.2 0.065

Chronic (non-cancer) 59.2 0.065

a

From the FIRST model. 

b

From the SCI-GROW model.

Halosulfuron-methyl, like most other sulfonylurea herbicides, is extremely mobile with a median 

Koc of 104 g/mL and Kf (Freundlich partition) values ranging from 0.32 to 3.6 in four test soils. 

Its persistence in soil and water appears to be highly variable. Halosulfuron-methyl has the 

potential to leach to groundwater, and also presents concerns for transport to surface water by 

runoff. 

IV. DEEM-FCIDTM Program and Consumption Information

Halosulfuron-methyl acute and chronic dietary exposure assessments were conducted using the 

DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA’s 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk 

for the following population subgroups: the general U.S. population, all infants (<1 year old),

children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 

50-99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup.

V. Toxicological Information

The risk assessment team confirmed endpoints that were previously selected and confirmed the 

reduction to 1X of the FQPA Safety Factor for all population subgroups (D358031, W. Phang, 

06/30/2009). 
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

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Toxicological endpoints for use in dietary exposure risk assessments are summarized in Table 3

below. 

Table 3. Summary of Toxicological Doses and Endpoints for Halosulfuron-methyl for Use in Dietary 

Exposure Risk Assessments.

Exposure/

Scenario

Point of 

Departure

Uncertainty/FQPA 

Safety Factors

RfD, PAD, 

Level of 

Concern 

Study and Toxicological Effects

Acute 

Dietary

(Females 13-

49 years of 

age)

NOAEL= 

50

mg/kg/day

UFA= 10x

UFH= 10x

FQPA SF= 1x

Acute RfD = 

0.5 

mg/kg/day

aPAD =0.5 

mg/kg/day

Developmental Toxicity - Rabbit

LOAEL = 150 mg/kg/day based on 

decreased mean litter size, increased 

number of resorptions (total and per dam) 

and increased postimplantation loss. 

(developmental toxicity)

Acute 

Dietary 

(General 

Population, 

including 

Infants and 

Children)

N/A N/A N/A No effect seen in the database that is 

likely the result of a single exposure; 

therefore, no dose/endpoint selected.

Chronic 

Dietary (All 

Populations)

NOAEL= 

10 

mg/kg/day

UFA= 10x

UFH= 10x

FQPA SF= 1x

Chronic RfD 

= 0.1

mg/kg/day

cPAD = 0.1 

mg/kg/day

Chronic Toxicity - Dog

LOAEL = 40 mg/kg/day based on 

decreased body weight gains in females.

Cancer (oral, 

dermal, 

inhalation)

Classification: “not likely to be carcinogenic to humans” by the oral route, based on no 

evidence of carcinogenicity from studies in rats and mice.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark 

the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no 

observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA = extrapolation 

from animal to human (interspecies). UFH = potential variation in sensitivity among members of the human population 

(intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference 

dose. N/A = not applicable.

VI. Results/Discussion

As stated above, for acute and chronic dietary assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure of the 

U.S. population and various population subgroups. The results reported in Table 3 are for the 

general U.S. Population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 

13-19, females 13-49, adults 20-49, and adults 50+ years. 

Results of Acute Dietary (Food and Drinking Water) Exposure Analysis 

The acute dietary (food and drinking water) exposure to halosulfuron-methyl is below HED’s 

level of concern. The acute dietary exposure estimate at the 95th percentile is <1% of the aPAD

for females 13-49 years old, the only population subgroup of concern.
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

PC Code: 128721

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Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The chronic dietary (food and drinking water) exposure to halosulfuron-methyl is below HED’s 

level of concern for the general U.S. population and all population subgroups. The chronic 

dietary exposure estimates are 2.0% of the cPAD for the general U.S. population and 5.5% of the 

cPAD for children 1-2 year olds, the most highly exposed population subgroup.

Table 3. Summary of Dietary Exposure and Risk for Halosulfuron-methyl. 

Population Subgroup

Acute Dietary 

(95th Percentile) Chronic Dietary

Dietary 

Exposure 

(mg/kg/day)

% aPAD*

Dietary 

Exposure

(mg/kg/day)

% cPAD*

General U.S. Population

N/A N/A

0.002050 2.0

All Infants (< 1 year old) 0.004871 4.9

Children 1-2 years old 0.005508 5.5

Children 3-5 years old 0.003884 3.9

Children 6-12 years old 0.002433 2.4

Youth 13-19 years old 0.001579 1.6

Adults 20-49 years old 0.001791 1.8

Adults 50+ years old 0.001737 1.7

Females 13-49 years old 0.003733 <1 0.001785 1.8

The population subgroup with the highest estimated exposure/risk is bolded.

VII. Characterization of Inputs/Outputs

The acute and chronic assessments are considered to be highly conservative and health 

protective. The residue levels used in the assessments for all commodities were the established 

or recommended tolerance levels. The assessments were conducted using the assumption that 

100% of the crop was treated. Default (DEEM 7.81) processing factors were used unless 

processing studies were available (tomato and potato) and modeled estimated drinking water 

concentrations were included in the assessments. 

These assessments could be refined, which would likely significantly decrease the estimated risk, 

with percent crop treated estimates, anticipated residues, or monitoring data. Since risk estimates 

are well below HED’s level of concern, a more highly refined analysis is not needed at this time.
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

PC Code: 128721

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VIII. Conclusions

Acute and chronic dietary exposure assessments were conducted for the proposed uses on

artichoke and caneberry subgroup 13-07A. The analyses were unrefined assessments, using 

tolerances for all commodities, the assumption of 100% CT, default (DEEM 7.81) processing 

factors when appropriate, and modeled water numbers. 

For both of the acute and chronic assessments, assessments for all populations of concern have 

risk estimates which are below HED’s level of concern. HED is confident that the acute and 

chronic assessments do not underestimate risk to the general U.S. population or any population 

subgroup. 

IX. List of Attachments

Attachment 1: Acute and Chronic Food plus Water Residue Input File

Attachment 2: Acute Results File

Attachment 3: Chronic Results File
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

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Attachment 1: Acute and Chronic Food plus Water Residue Input File.

Filename: C:\Documents and Settings\MNEGUSSI\My Documents\DEEM Version 3.16\Halosulfuronmethyl\ACUTE & CHRONIC 022713.R08

Chemical: halosulfuron-methyl

RfD(Chronic): .1 mg/kg bw/day NOEL(Chronic): 10 mg/kg bw/day

RfD(Acute): .5 mg/kg bw/day NOEL(Acute): 50 mg/kg bw/day

Date created/last modified: 02-27-2013/14:16:43 Program ver. 3.16, 03-08-d

Comment: Acute is only for Females 13-49 yrs; New Uses Artichoke and Caneberry sugroup 13-

07A

-----------------------------------------------------------------------------------

 EPA Crop Def Res Adj.Factors Comment

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ -------

0103015000 1CD Arrowroot, flour 0.050000 1.000 1.000 9E7577

0103015001 1CD Arrowroot, flour-babyfood 0.050000 1.000 1.000 9E7577

0103017000 1CD Artichoke, Jerusalem 0.050000 1.000 1.000 9E7577

0103082000 1CD Cassava 0.050000 1.000 1.000 9E7577

0103082001 1CD Cassava-babyfood 0.050000 1.000 1.000 9E7577

0103139000 1CD Dasheen, corm 0.050000 1.000 1.000 9E7577

0103166000 1CD Ginger 0.050000 1.000 1.000 9E7577

0103166001 1CD Ginger-babyfood 0.050000 1.000 1.000 9E7577

0103167000 1CD Ginger, dried 0.050000 1.000 1.000 9E7577

0103296000 1C Potato, chips 0.050000 1.000 1.000 9E7577

0103297000 1C Potato, dry (granules/ flakes) 0.050000 1.000 1.000 9E7577

0103297001 1C Potato, dry (granules/ flakes)-b 0.050000 1.000 1.000 9E7577

0103298000 1C Potato, flour 0.050000 1.000 1.000 9E7577

0103298001 1C Potato, flour-babyfood 0.050000 1.000 1.000 9E7577

0103299000 1C Potato, tuber, w/peel 0.050000 1.000 1.000 9E7577

0103299001 1C Potato, tuber, w/peel-babyfood 0.050000 1.000 1.000 9E7577

0103300000 1C Potato, tuber, w/o peel 0.050000 1.000 1.000 9E7577

0103300001 1C Potato, tuber, w/o peel-babyfood 0.050000 1.000 1.000 9E7577

0103366000 1CD Sweet potato 0.050000 1.000 1.000 9E7577

0103366001 1CD Sweet potato-babyfood 0.050000 1.000 1.000 9E7577

0103371000 1CD Tanier, corm 0.050000 1.000 1.000 9E7577

0103387000 1CD Turmeric 0.050000 1.000 1.000 9E7577

0103406000 1CD Yam, true 0.050000 1.000 1.000 9E7577

0103407000 1CD Yam bean 0.050000 1.000 1.000 9E7577

0402322000 4B Rhubarb 0.050000 1.000 1.000 9E7577

0600347000 6 Soybean, seed 0.050000 1.000 1.000 8F7424

0600349000 6 Soybean, soy milk 0.050000 1.000 1.000 

0600349001 6 Soybean, soy milk-babyfood or in 0.050000 1.000 1.000 

0600350000 6 Soybean, oil 0.050000 1.000 1.000 8F7424

0600350001 6 Soybean, oil-babyfood 0.050000 1.000 1.000 

0601043000 6A Bean, snap, succulent 0.050000 1.000 1.000 

0601043001 6A Bean, snap, succulent-babyfood 0.050000 1.000 1.000 

0602031000 6B Bean, broad, succulent 0.050000 1.000 1.000 9E7577

0602033000 6B Bean, cowpea, succulent 0.050000 1.000 1.000 9E7577

0602037000 6B Bean, lima, succulent 0.050000 1.000 1.000 9E7577

0602255000 6B Pea, succulent 0.050000 1.000 1.000 9E7577

0602255001 6B Pea, succulent-babyfood 0.050000 1.000 1.000 9E7577

0602259000 6B Pea, pigeon, succulent 0.050000 1.000 1.000 9E7577

0603030000 6C Bean, black, seed 0.050000 1.000 1.000 

0603032000 6C Bean, broad, seed 0.050000 1.000 1.000 

0603034000 6C Bean, cowpea, seed 0.050000 1.000 1.000 

0603035000 6C Bean, great northern, seed 0.050000 1.000 1.000 

0603036000 6C Bean, kidney, seed 0.050000 1.000 1.000 

0603038000 6C Bean, lima, seed 0.050000 1.000 1.000 

0603039000 6C Bean, mung, seed 0.050000 1.000 1.000 

0603040000 6C Bean, navy, seed 0.050000 1.000 1.000 

0603041000 6C Bean, pink, seed 0.050000 1.000 1.000 

0603042000 6C Bean, pinto, seed 0.050000 1.000 1.000 

0603098000 6C Chickpea, seed 0.050000 1.000 1.000 

0603098001 6C Chickpea, seed-babyfood 0.050000 1.000 1.000 
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

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0603099000 6C Chickpea, flour 0.050000 1.000 1.000 

0603182000 6C Guar, seed 0.050000 1.000 1.000 

0603182001 6C Guar, seed-babyfood 0.050000 1.000 1.000 

0603348000 6C Soybean, flour 0.050000 1.000 1.000 

0603348001 6C Soybean, flour-babyfood 0.050000 1.000 1.000 

0801374000 8A Tomatillo 0.050000 1.000 1.000 0F6169

0801375000 8A Tomato 0.050000 1.000 1.000 0F6169

0801375001 8A Tomato-babyfood 0.050000 1.000 1.000 

0801376000 8A Tomato, paste 0.050000 1.000 1.000 0F6169

0801376001 8A Tomato, paste-babyfood 0.050000 1.000 1.000 

0801377000 8A Tomato, puree 0.050000 1.000 1.000 0F6169

0801377001 8A Tomato, puree-babyfood 0.050000 1.000 1.000 

0801378000 8A Tomato, dried 0.050000 14.300 1.000 0F6169

0801378001 8A Tomato, dried-babyfood 0.050000 14.300 1.000 

0801379000 8A Tomato, juice 0.050000 1.500 1.000 0F6169

0802148000 8BC Eggplant 0.050000 1.000 1.000 

0802234000 8BC Okra 0.050000 1.000 1.000 9E7577

0802270000 8B Pepper, bell 0.050000 1.000 1.000 

0802270001 8B Pepper, bell-babyfood 0.050000 1.000 1.000 

0802271000 8B Pepper, bell, dried 0.050000 1.000 1.000 

0802271001 8B Pepper, bell, dried-babyfood 0.050000 1.000 1.000 

0802272000 8BC Pepper, nonbell 0.050000 1.000 1.000 

0802272001 8BC Pepper, nonbell-babyfood 0.050000 1.000 1.000 

0802273000 8BC Pepper, nonbell, dried 0.050000 1.000 1.000 

0901075000 9A Cantaloupe 0.100000 1.000 1.000 0E6206

0901187000 9A Honeydew melon 0.100000 1.000 1.000 0E6206

0901399000 9A Watermelon 0.100000 1.000 1.000 

0901400000 9A Watermelon, juice 0.100000 1.000 1.000 

0902021000 9B Balsam pear 0.500000 1.000 1.000 

0902088000 9B Chayote, fruit 0.500000 1.000 1.000 

0902102000 9B Chinese waxgourd 0.500000 1.000 1.000 

0902135000 9B Cucumber 0.500000 1.000 1.000 0E6085

0902308000 9B Pumpkin 0.500000 1.000 1.000 0E6085

0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 

0902356000 9B Squash, summer 0.500000 1.000 1.000 0E6085

0902356001 9B Squash, summer-babyfood 0.500000 1.000 1.000 

0902357000 9B Squash, winter 0.500000 1.000 1.000 0E6085

0902357001 9B Squash, winter-babyfood 0.500000 1.000 1.000 

1100007000 11 Apple, fruit with peel 0.050000 1.000 1.000 9E7577

1100008000 11 Apple, peeled fruit 0.050000 1.000 1.000 9E7577

1100008001 11 Apple, peeled fruit-babyfood 0.050000 1.000 1.000 9E7577

1100009000 11 Apple, dried 0.050000 8.000 1.000 9E7577

1100009001 11 Apple, dried-babyfood 0.050000 8.000 1.000 9E7577

1100010000 11 Apple, juice 0.050000 1.300 1.000 9E7577

1100010001 11 Apple, juice-babyfood 0.050000 1.300 1.000 9E7577

1100011000 11 Apple, sauce 0.050000 1.000 1.000 9E7577

1100011001 11 Apple, sauce-babyfood 0.050000 1.000 1.000 9E7577

1301055000 13A Blackberry 0.050000 1.000 1.000 DP# D4

 Full comment: DP# D405659

1301056000 13A Blackberry, juice 0.050000 1.000 1.000 DP# D4

 Full comment: DP# D405659

1301056001 13A Blackberry, juice-babyfood 0.050000 1.000 1.000 DP# D4

 Full comment: DP# D405659

1301058000 13A Boysenberry 0.050000 1.000 1.000 DP# D4

 Full comment: DP# D405659

1301208000 13A Loganberry 0.050000 1.000 1.000 DP# D4

 Full comment: DP# D405659

1301320000 13A Raspberry 0.050000 1.000 1.000 DP# D4

 Full comment: DP# D405659

1301321000 13A Raspberry, juice 0.050000 1.000 1.000 DP# D4

 Full comment: DP# D405659

1302057000 13B Blueberry 0.050000 1.000 1.000 9E7577

1302057001 13B Blueberry-babyfood 0.050000 1.000 1.000 9E7577

1302136000 13B Currant 0.050000 1.000 1.000 9E7577

1302137000 13B Currant, dried 0.050000 1.000 1.000 9E7577

1302149000 13B Elderberry 0.050000 1.000 1.000 9E7577

1302174000 13B Gooseberry 0.050000 1.000 1.000 9E7577
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

PC Code: 128721

______________________________________________________________________________________

Page 11 of 14

1302191000 13B Huckleberry 0.050000 1.000 1.000 9E7577

1400003000 14 Almond 0.050000 1.000 1.000 8F4937

1400003001 14 Almond-babyfood 0.050000 1.000 1.000 

1400004000 14 Almond, oil 0.050000 1.000 1.000 8F4937

1400004001 14 Almond, oil-babyfood 0.050000 1.000 1.000 

1400059000 14 Brazil nut 0.050000 1.000 1.000 8F4937

1400068000 14 Butternut 0.050000 1.000 1.000 

1400081000 14 Cashew 0.050000 1.000 1.000 8F4937

1400092000 14 Chestnut 0.050000 1.000 1.000 8F4937

1400155000 14 Hazelnut 0.050000 1.000 1.000 8F4937

1400156000 14 Hazelnut, oil 0.050000 1.000 1.000 

1400185000 14 Hickory nut 0.050000 1.000 1.000 

1400213000 14 Macadamia nut 0.050000 1.000 1.000 8F4937

1400269000 14 Pecan 0.050000 1.000 1.000 8F4937

1400282000 14 Pistachio 0.050000 1.000 1.000 8F4937

1400391000 14 Walnut 0.050000 1.000 1.000 8F4937

1500120000 15 Corn, field, flour 0.050000 1.000 1.000 6F4661

1500120001 15 Corn, field, flour-babyfood 0.050000 1.000 1.000 

1500121000 15 Corn, field, meal 0.050000 1.000 1.000 6F4661

1500121001 15 Corn, field, meal-babyfood 0.050000 1.000 1.000 

1500122000 15 Corn, field, bran 0.050000 1.000 1.000 6F4661

1500123000 15 Corn, field, starch 0.050000 1.000 1.000 6F4661

1500123001 15 Corn, field, starch-babyfood 0.050000 1.000 1.000 

1500124000 15 Corn, field, syrup 0.050000 1.500 1.000 6F4661

1500124001 15 Corn, field, syrup-babyfood 0.050000 1.500 1.000 

1500125000 15 Corn, field, oil 0.050000 1.000 1.000 6F4661

1500125001 15 Corn, field, oil-babyfood 0.050000 1.000 1.000 

1500126000 15 Corn, pop 0.050000 1.000 1.000 6F4661

1500127000 15 Corn, sweet 0.050000 1.000 1.000 6F4661

1500127001 15 Corn, sweet-babyfood 0.050000 1.000 1.000 

1500226000 15 Millet, grain 0.010000 1.000 1.000 

1500323000 15 Rice, white 0.050000 1.000 1.000 8F4937

1500323001 15 Rice, white-babyfood 0.050000 1.000 1.000 

1500324000 15 Rice, brown 0.050000 1.000 1.000 8F4937

1500324001 15 Rice, brown-babyfood 0.050000 1.000 1.000 

1500325000 15 Rice, flour 0.050000 1.000 1.000 8F4937

1500325001 15 Rice, flour-babyfood 0.050000 1.000 1.000 

1500326000 15 Rice, bran 0.050000 1.000 1.000 8F4937

1500326001 15 Rice, bran-babyfood 0.050000 1.000 1.000 

1500344000 15 Sorghum, grain 0.050000 1.000 1.000 

1500345000 15 Sorghum, syrup 0.050000 1.000 1.000 

1500405000 15 Wild rice 0.050000 1.000 1.000 8F4937

2003128000 20C Cottonseed, oil 0.050000 1.000 1.000 8F4937

2003128001 20C Cottonseed, oil-babyfood 0.050000 1.000 1.000 

3100044000 31 Beef, meat 0.050000 1.000 1.000 

3100044001 31 Beef, meat-babyfood 0.050000 1.000 1.000 

3100045000 31 Beef, meat, dried 0.050000 1.900 1.000 

3100046000 31 Beef, meat byproducts 1.000000 1.000 1.000 

3100046001 31 Beef, meat byproducts-babyfood 1.000000 1.000 1.000 

3100047000 31 Beef, fat 0.050000 1.000 1.000 

3100047001 31 Beef, fat-babyfood 0.050000 1.000 1.000 

3100048000 31 Beef, kidney 1.000000 1.000 1.000 

3100049000 31 Beef, liver 1.000000 1.000 1.000 

3100049001 31 Beef, liver-babyfood 1.000000 1.000 1.000 

3200169000 32 Goat, meat 0.050000 1.000 1.000 

3200170000 32 Goat, meat byproducts 1.000000 1.000 1.000 

3200171000 32 Goat, fat 0.050000 1.000 1.000 

3200172000 32 Goat, kidney 1.000000 1.000 1.000 

3200173000 32 Goat, liver 1.000000 1.000 1.000 

3300189000 33 Horse, meat 0.050000 1.000 1.000 

3400292000 34 Pork, meat byproducts 0.100000 1.000 1.000 3F4193

3400292001 34 Pork, meat byproducts-babyfood 0.100000 1.000 1.000 

3400294000 34 Pork, kidney 0.100000 1.000 1.000 3F4193

3400295000 34 Pork, liver 0.100000 1.000 1.000 3F4193

3500339000 35 Sheep, meat 0.050000 1.000 1.000 

3500339001 35 Sheep, meat-babyfood 0.050000 1.000 1.000 

3500340000 35 Sheep, meat byproducts 1.000000 1.000 1.000 
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

PC Code: 128721

______________________________________________________________________________________

Page 12 of 14

3500341000 35 Sheep, fat 0.050000 1.000 1.000 

3500341001 35 Sheep, fat-babyfood 0.050000 1.000 1.000 

3500342000 35 Sheep, kidney 1.000000 1.000 1.000 

3500343000 35 Sheep, liver 1.000000 1.000 1.000 

3600222000 36 Milk, fat 0.050000 1.000 1.000 

3600222001 36 Milk, fat-baby food/infant formu 0.050000 1.000 1.000 

3600223000 36 Milk, nonfat solids 0.050000 1.000 1.000 

3600223001 36 Milk, nonfat solids-baby food/in 0.050000 1.000 1.000 

3600224000 36 Milk, water 0.050000 1.000 1.000 

3600224001 36 Milk, water-babyfood/infant form 0.050000 1.000 1.000 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.050000 1.000 1.000 

8601000000 86A Water, direct, all sources 0.059200 1.000 1.000 DP#358

 Full comment: DP#358032

8602000000 86B Water, indirect, all sources 0.059200 1.000 1.000 

9500016000 O Artichoke, globe 0.050000 1.000 1.000 

9500019000 O Asparagus 0.800000 1.000 1.000 1F6229

9500362000 O Sugarcane, sugar 0.050000 1.000 1.000 6F4661

9500362001 O Sugarcane, sugar-babyfood 0.050000 1.000 1.000 

9500363000 O Sugarcane, molasses 0.050000 1.000 1.000 6F4661

9500363001 O Sugarcane, molasses-babyfood 0.050000 1.000 1.000 
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

PC Code: 128721

______________________________________________________________________________________

Page 13 of 14

Attachment 2: Acute Results File.

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID ACUTE Analysis for HALOSULFURON-METHYL NHANES 2003-2008 2-Day

Residue file: ACUTE & CHRONIC 022713.R08 Adjustment factor #2 NOT used.

Analysis Date: 02-27-2013/14:18:43 Residue file dated: 02-27-2013/14:16:43

NOEL (Acute) = 50.000000 mg/kg body-wt/day

RAC/FF intake summed over 24 hours

Run Comment: "Acute is only for Females 13-49 yrs; New Uses Artichoke and Cane

berry sugroup 13-07A"

===============================================================================

Summary calculations--per capita:

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile----

Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- --------

Female 13-49:

 0.004091 0.82 12221 0.005756 1.15 8686 0.008278 1.66 6040 
Halosulfuron-methyl Dietary Exposure and Risk Assessment DP Number: 405660

PC Code: 128721

______________________________________________________________________________________

Page 14 of 14

Attachment 3: Chronic Results File.

U.S. EPA Ver. 3.16, 03-08-d

DEEM-FCID Chronic analysis for HALOSULFURON-METHYL NHANES 2003-2008 2-day

Residue file name: C:\Documents and Settings\MNEGUSSI\My Documents\DEEM Version 

3.16\Halosulfuron-methyl\ACUTE & CHRONIC 022713.R08

 Adjustment factor #2 NOT used.

Analysis Date 02-27-2013/14:29:21 Residue file dated: 02-27-2013/14:16:43

Reference dose (RfD, Chronic) = .1 mg/kg bw/day

COMMENT 1: Acute is only for Females 13-49 yrs; New Uses Artichoke and Caneberry sugroup 

13-07A

===============================================================================

 Total exposure by population subgroup

-------------------------------------------------------------------------------

 Total Exposure

 -----------------------------------

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ----------------

Total US Population 0.002050 2.0%

Hispanic 0.002153 2.2%

Non-Hisp-White 0.002066 2.1%

Non-Hisp-Black 0.001733 1.7%

Non-Hisp-Other 0.002316 2.3%

Nursing Infants 0.002051 2.1%

Non-Nursing Infants 0.006130 6.1%

Female 13+ PREG 0.001882 1.9%

Children 1-6 0.004358 4.4%

Children 7-12 0.002285 2.3%

Male 13-19 0.001591 1.6%

Female 13-19/NP 0.001566 1.6%

Male 20+ 0.001700 1.7%

Female 20+/NP 0.001826 1.8%

Seniors 55+ 0.001718 1.7%

All Infants 0.004871 4.9%

Female 13-50 0.001784 1.8%

Children 1-2 0.005508 5.5%

Children 3-5 0.003884 3.9%

Children 6-12 0.002433 2.4%

Youth 13-19 0.001579 1.6%

Adults 20-49 0.001791 1.8%

Adults 50-99 0.001737 1.7%

Female 13-49 0.001785 1.8%