UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MEMORANDUM 

Date: 06/16/2014 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

SUBJECT: Fenazaquin: Acute and Chronic Aggregate Dietary Exposure and Risk 

Assessments for the Section 3 Registration Action on Almonds and Cherries. 

PC Code: 044501 

Decision No.: 444200 

Petition No.: l F7825 

Risk Assessment Type: Dietary 

TXRNo.: NA 

MRIDNo.: NA 

DP Barcode: D391808 

Registration No.: 10163-295; 10163-GEE 

Regulatory Action: Section 3 Registration 

Case No.: NA 

CAS No.: 120928-09-8 

40 CFR: §180.632 

FROM: Cassi Walls, Ph.D., Senior Biologist ~ t. t)ol/b. 

Risk Assessment Branch III 

Health Effects Division (HED, 7509P) 

THROUGH: Sheila 

Mohsen 

Piper, 

Sahafeyan, 

Chemist 

Chemist 

8~ ()_~ · ~ r ti\. , ~ 

Dietary Exposure Science Advisory Council (DESAC) 

TO: Olga Odiott, Risk Manager Reviewer 

Insecticide and Rodenticide Branch 

Registration Division (7505P) 

Executive Summary 

Acute and chronic aggregate dietary food and drinking water exposure and risk assessments were 

conducted using the Dietary Exposure Evaluation Model software with the Food Commodity 

Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food consumption 

data from the U.S. Department of Agriculture's (USDA's) National Health and Nutrition 

Examination Survey, What We Eat in America, (NHANES/WWEIA). The analyses were 

conducted in support of a human-health risk assessment for the proposed Section 3 uses of 

fenazaquin on almonds and cherries. This memorandum was reviewed by two peer reviewers of 

the DESAC, per DESAC SOP 2012.1. 

Page I of 14 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 391808 

Acute Dietary Exposure Assessment 

The acute dietary risk assessment is a conservative evaluation based on proposed tolerance level 

residues for almonds and cherries and on current tolerances for imported commodities (e.g., 

apples, pears, and citrus fruit) with the assumption that 100% of the crops are treated with 

fenazaquin. DEEM 7 .81 default processing factors were utilized for imported commodities and 

almonds and cherries. 

The acute dietary assessments using the DEEM-FCIDTM Model were reported at the 95th 

percentile of exposure for the general U.S. population and all of its subgroups. Risk estimates 

were all well below 100% of the acute Population-Adjusted Dose (aPAD) threshold level of 

concern. Fenazaquin acute dietary exposure for food and water was estimated to be 0.0043 

mg/kg/day at 3% of the aPAD for the general U.S. population. Acute dietary exposure of food 

and water for the most highly exposed population subgroup, children 1-2 years of age, was 

estimated to be 0.015 mg/kg/day at 10% of the aPAD. 

Chronic Dietary Exposure Assessment 

The chronic dietary risk assessment is a conservative evaluation based on proposed tolerance 

level residues for almonds and cherries and on current tolerances for imported commodities (e.g., 

apples, pears, and citrus fruit) with the assumption that 100% of the crops are treated with 

fenazaquin. DEEM 7.81 default processing factors were utilized for the imported commodities 

and almonds and cherries. 

Risk estimates were all found to be well below 100% of the chronic Population-Adjusted Dose 

( cPAD) threshold level of concern. Fenazaquin chronic dietary exposure of food and water was 

estimated to be 0.00095 mg/kg/day at 2% of the cPAD for the general U.S. population. In 

comparison, chronic dietary exposure from food and water for the most highly exposed 

population subgroup, children 1-2 years of age, was estimated to be 0.0048 mg/kg/day at 10% of 

the cPAD. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose that HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the population-adjusted dose (PAD). The PAD is equivalent to the 

point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety 

factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in 

more detail are available on the EPA/pesticides web site: "Available Information on Assessing 

Exposure from Pesticides, A User's Guide," 06/21/00, web link: 

Page 2 of 14 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 39 I 808 

http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 

(08/20/99). 

The most recent dietary risk assessment for fenazaquin was conducted by Debra Rate (10/27 /08, 

DP344660). 

II. Residue Information 

Fenazaquin is a quinazoline class insecticide/acaricide formulated by the Gowan Company for 

the control of mites and white flies on crops in various parts of the world. Tolerances have been 

established for fenazaquin, or 4-tert-butylphenethyl quinazolin-4-yl ether, on the imported 

commodities apple, citrus oil, citrus fruit crop group 10 except grapefruit, and pear ( 40 CFR 

180.632). The current petition proposes the first food uses for fenazaquin on US domestic crops 

of almonds and cherries. 

Metabolism studies were conducted using [

14C]fenazaquin on both apples and oranges, as well as 

on dairy goat ruminants (MRID Nos. 45029914 & 45029915, 4505440 I, and 45029916). The 

metabolism of fenazaquin in plants and animals is understood based upon this data. The 

tolerance expression for the residue of concern in plant and animal commodities is parent 

fenazaquin. 

The acute and chronic dietary analyses assume that fenazaquin residues are in/on all registered 

and proposed food commodities at tolerance levels. The established and recommended 

tolerances levels used in the dietary analyses are summarized in Table 1. 

Table 1. Summary for Fenazaquin Residue Levels Used in 

Acute and Chronic Dietary Analyses 

Established Recommended 

Commodity Tolerance Tolerance 

(ppm) (ppm) 

Apple 0.2 NA 

Pear 0.2 NA 

Citrus fruits, except grapefruit 0.5 NA 

Citrus Oil 10.0 NA 

Almond NA 0.02 

Cherry NA 2.0 

Ill. Percent Crop Treated Information 

For both the acute and chronic dietary assessments, it was assumed that 100% of all the raw 

agricultural commodities (RACs) consumed domestically are treated with fenazaquin. 

Page 3 of 14 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 391808 

IV. Drinking Water Data 

The drinking water residues used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED) in the following memorandum: "Drinking 

Water Assessment to Support First Fenazaquin (4-tert-butylphenethyl quinazolin-4-yl ether) Use 

on Food Crops" (D394030, James Hetrick, 03/08/ 12) and incorporated directly into this dietary 

assessment. Water residues were incorporated in the DEEM-FCID into the food categories 

"water, direct, all sources" and "water, indirect, all sources." 

The drinking water assessment was conducted using the total toxic residue (TTR) approach. The 

residues considered in this assessment include fenazaquin (parent),4-(2-( 4-(1, 1-

imethylethyl)phenyl)ethoxy)quinazolone (Metabolite 1 ), and 2-Methyl-2-( 4-{2-[(2-oxo-1,2-

dihydroquinazolin-4-yl)oxy ]ethyl }phenyl) propanoic acid (Metabolite 2). 

The modeling for fenazaquin and its degradation products was conducted using a total residue 

approach. Tier I groundwater estimated drinking water concentrations (EDWCs) were calculated 

using SCI-GROW (~creening Concentration in Groundwater, version 2.3, August 8, 2003). Tier 

II surface water EDWCs were calculated using PRZM (£.esticide Root Zone Model, version 

3.12.3, June 2006) and EXAMS (EXposure Analysis Modeling ~stem, version 2.98.04.06, 

April 2005) models in the PE5 shell. All Tier II surface water modeling was corrected for 

default percent cropped area (PCA) of 0.87. For additional details on the modeling, refer to 

http://www.epa.gov/oppefed 1 /models/water/. 

For the proposed almond and cherry uses of fenazaquin, the Tier II surface water modeling 

showed that concentrations of fenazaquin residues are not expected to exceed 5. 7 4 μg/L for a 1 

in 10 year daily peak, 2.09 μg/L for 1 in 10 year annual average, and 1.33 μg/L for the 30 year 

annual average. Tier I ground water modeling indicates the fenazaquin residue concentrations are 

not expected to exceed 0.0704 μg/L for peak and long-term average concentrations. No 

monitoring data are available to assess fenazaquin concentrations in ground and surface waters. 

A summary of the recommended EDWCs (5.74 ppb for acute and 2.09 ppb for chronic) used in 

the dietary analyses is presented in Table 2. 

Table 2. Estimated Drinking Concentrations for Total Toxic Residues of Fenazaquin in Surface 

and Ground Source Water from Proposed Fenazaquin Uses 

l in 10 year Concentration 

Scenario Peak 

(acute) 

Surface Ml cherries; 

water a aerial aoo 5.74 

Ground 

water b 

• From the Tier II PRZM-EXAMs modeling system. 

b From the Tier I SCI-GROW model. 

Bolded values were used in the dietary analyses. 

(u J/L) 

Annual Average 

(non-cancer chronic) 

2.09 

0.0704 

Page 4of14 

30 year Annual 

Aver.age (μg/L) 

(cancer) 

1.33 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 39 1808 

V. DEEM-FCID Program and Consumption Information 

Fenazaquin acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA's 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods "as consumed" (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<l year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old. 

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup. 

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or "matched" in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment. 

VI. Toxicological Information 

All information specific to the fenazaquin toxicological profile is presented in the risk 

assessment document for this petition (DP Number 389845). Acute and chronic dietary 

endpoints were selected based on fenazaquin toxicity study results. For acute dietary exposure, 

the results from the immunotoxicity study were considered in selecting toxicity endpoints and 

points of departure (POD) for risk assessment. The NOAEL of 15 mg/kg/day was selected as the 

POD based on clinical signs (i.e. general ataxia/hypoactivity) observed after a single exposure at 

Page 5of 14 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 391808 

the lowest observed adverse effect level (LOAEL) of 30 mg/kg/day. The endpoint is appropriate 

for this exposure scenario since the effects were seen after a single oral administration. In 

addition, it is also protective of the effects seen in the acute neurotoxicity study at 60 mg/kg 

(LOAEL). An acute reference dose (aRfD) of 0.15 mg/kg/day was derived from the no observed 

adverse effect level (NOAEL) with the application of an Uncertainty Factor of I OOx (1 OX interspecies extrapolation, 1 OX intra-species variations factor). 

A separate endpoint of concern for pregnant females ( 13-49 years of age) was not selected since 

no endpoints attributable to a single dose were identified in the developmental toxicity studies in 

rats and rabbits. 

For chronic dietary exposure, the toxicity endpoints of decreases in body weight, food 

consumption, and food efficiency were selected, and these effects were seen at similar dose 

levels in both subchronic (15 mg/kg/day) and chronic oral toxicity studies in dogs (12 

mg/kg/day). The NOAELs were the same for both chronic and subchronic toxicity studies in 

dogs. The results from these two studies demonstrated no increase in severity with increased 

treatment durations. Hence, the subchronic and chronic toxicity studies in dogs were appropriate 

to be employed as co-critical studies for toxicity end point and point of departure selections for 

the chronic exposure scenario. A chronic reference dose (cRfD) of 0.05 mg/kg/day was derived 

from a NOAEL of 5 mg/kg/day and an UF of 1 OOx. 

The lOX FQPA Safety Factor can be reduced to IX because the toxicity database is complete, 

there is no evidence of sensitivity/susceptibility in the developing organism, no neurotoxicity, 

and no residual uncertainty in the exposure data. A summary of the doses and toxicological 

endpoints selected for the dietary exposure scenarios which were perfonned are provided in 

Table 3. 

Table 3. Toxicological Doses and Endpoints for Fenazaquin for Use in Dietary Health Risk 

Assessments. 

Exposure/ Point of Uncertainty/ 

Scenario Departure FQPA Safety RfD,PAD Study and Toxicological Effects 

(POD) Factors 

Acute Dietary NOAEL= UFA= !Ox aRfD = 0.15 lmmunotoxici~ - Rat 

(General 15 mg/kg/day UFH= !Ox mg/kg/day LOAEL = 30 mg/kg/day 

population) FQPA SF= Ix Based on clinical signs (general 

aPAD = 0.15 ataxia/hypo-activity) observed in I 

mg/kg/day animal on Day 02 and 3 animals on 

Day 03 of dosing. 

Chronic NOAEL- UFA= !Ox cRfD = 0.05 Co-Critical: Subchronic and Chronic 

Dietary (All 5 mg/kg/day UFH= !Ox mg/kg/day Toxicity - Dog 

Populations) FQPA SF= Ix 

cPAD = 0.05 Subchronic Toxicity - Dog 

mg/kg/day LOAEL = 15 mg/kg/day 

Based on decreased body weight, body 

weight gain, and food 

consumption/efficiency. 

Chronic Toxicity - Dog 

LOAEL = 12 mg/kg/day 

Based on decreased body weight, body 

weight gain, and food 

consumption/efficiency 

Page 6of14 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 39 1808 

Table 3. Toxicological Doses and Endpoints for Fenazaquin for Use in Dietary Health Risk 

Assessments. 

Point of Uncertainty/ Exposure/ 

Scenario Departure FQPA Safety RfD, PAD Study and Toxicological Effects 

(POD) Factors 

Cancer (oral, Classification: "Not likely to be Carcinogenic to I Ju mans" based on the absence of significant tumor increases 

dermal, in two adequate rodent carcinogenicity studies. 

inhalation) 

Point of Departure (POD) = A data point or an estimated point that 1s derived from observed dose-response data and used to 

mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL 

= no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA= extrapolation 

from animal to human (interspecies). UFH =potential variation in sensitivity among members of the human population 

(intraspecies). FQPA SF= FQPA Safely Factor. PAD = population adjusted dose (a = acute, c =chronic). RID = reference dose. 

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure and risk of the U.S. 

population and various population subgroups. The results reported in Table 4 are for the general 

U.S. Population, all infants (<l year old), children 1-2, children 3-5, children 6-12, youth 13-19, 

females 13-49, adults 20-49, and adults 50-99 years. Cancer risk is determined for the general 

U.S. population only. 

Results of Acute and Chronic Dietary (Food and Drinking Water) Exposure and Risk Analysis 

Acute and chronic dietary risk analyses were conducted with the DEEM-FCID model using 

conservative exposure assumptions for fenazaquin. The acute dietary results at the 95th 

percentile indicate risk estimates are reasonably below the 100% of the aPAD threshold level of 

concern for each population subgroup. The acute dietary risk for the U.S. population was 

estimated to be 3% of the aPAD with an exposure of 0.004348 mg/kg/day. For the most highly 

exposed population subgroup, children 1-2 years of age, acute dietary risk was estimated to be 

10% of the aPAD with an exposure of 0.015404 mg/kg/day. Additionally, chronic analysis 

yielded risk estimates well below the l 00% of the cP AD threshold level of concern for each 

population subgroup. The chronic dietary risk for the U.S. population was estimated to be 2% of 

the cPAD with an exposure of0.000949 mg/kg/day. For children 1-2 years of age, chronic 

dietary risk is estimated to be 10% of the cPAD with an exposure of0.004753 mg/kg/day. An 

overview summarizing the results of the acute and chronic dietary assessments with the 

population subgroup having the highest exposure being noted in bold is presented in Table 4. 

Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Fenazaquin. 

Acute Dietary Chronic Dietary Cancer (95th Percentile) 

Population Subgroup Dietary Dietary Dietary 

Exposure % aPAD* Exposure % cPAD* Exposure Risk 

(mg/ kg/day) (m!?/k!?/dav) (mg/ ki!/day) 

General U.S. Population 0.004348 3 0.000949 2 

All Infants (<I year old) 0.007455 5 0.001831 4 

N/A N/A 

Children 1-2 years old 0.015404 10 0.004753 10 

Children 3-5 years old 0.01 1604 8 0.003358 7 

Page 7of14 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 391808 

Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Fenazaquin. 

Acute Dietary Chronic Dieta ry Cancer (95th Percentile) 

P opulation Subgroup Dietary Dietary Dieta ry 

Exposure % aPAD* Exposure % cPAD* Exposure Risk 

(mg/kg/day) (mg/kg/day) (m:g/kg/day) 

Children 6-12 years old 0.006134 4 0.001481 3 

Youth 13-19 years old 0.003965 3 0.000777 2 

Adults 20-49 years old 0.002985 2 0.000586 I 

Adults 50-99 years old 0.002568 2 0.000619 I 

Females 13-49 years old 0.003034 2 0.000613 I 

*The subpopulation with the highest risk estimates 

VIII. Characterization of Inputs/Outputs 

The acute and chronic dietary exposure and risk analyses are based on tolerance-level residues, 

100% crop treated assumptions, and default processing factors. Various refinements could be 

made to the assessments. However, as there are no risk estimates of concern, no refinements 

were incorporated. 

IX. Conclusions 

The conservative acute and chronic dietary risk assessments conducted with DEEM-FCID 

indicate that food and drinking water exposures to fenazaquin are well below HED's level of 

concern. The resulting acute risks for fenazaquin are reported at the 95th percentile of exposure 

for the general U.S. population and all of its subgroups. Acute dietary exposure to fenazaquin 

was estimated to be 3% of the aPAD for the general U.S. population. Chronic dietary exposure 

to fenazaquin was estimated to be 2% of the cPAD for the general U.S. population. For the most 

highly exposed population subgroup, children 1-2 years of age, both acute and chronic dietary 

exposures were estimated to be well below HED's level of concern. For this subgroup, the acute 

exposure was 10% of the aPAD and the chronic exposure was 10% of the cPAD. 

X. List of Attachments 

• 

• 

• 

• 

• 

• 

Acute Residue Input File 

Acute Results (food and water) File 

Acute Results (water only) File 

Chronic Residue Input File 

Chronic Results (food and water) File 

Chronic Results (water only) File 

Page 8 of 14 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 391 808 

Acute Residue Input File 

Fil ename : C:\Users\cwal ls\Document s\Cassi\HED\Fenazaquin\dietary\almond 

cherr y\FENAZAQUIN acute 060514 .R08 

Chemical : f enaza quin 

RfD(Chronic): .05 mg/kg bw/day NOEL(Chr onic): O mg/kg bw/day 

RfD{Acute): . 15 mg/kg bw/day NOEL(Acute): O mg/kg bw/day 

Dat e c r eated/last modi fied : 06-05-2014/15:10:14 Pr ogram ver. 3.16, 03-08-d 

EPA Crop 

Code Gr p Commodit y Name 

1 001106000 lOA 

1 001107000 l OA 

100 1108000 lOA 

1001 24 0000 lOA 

1001241000 lOA 

10012 41001 lOA 

1 00 1242000 l OA 

1001 369000 l OA 

1 001370000 lOA 

1002197000 108 

1 0021 990 00 108 

1 002200000 1 08 

1002200001 l OB 

1002201 000 lOB 

1 002206000 108 

1002207000 108 

1002207001 108 

1 003307000 lOC 

11 00007000 11 

1100008000 11 

1100008001 11 

1100009000 11 

1100009001 11 

1100010000 11 

1100010001 11 

1100011000 11 

1100011001 11 

1100266000 11 

1100266001 11 

1100267000 11 

1100268000 11 

1100268001 11 

1100310000 11 

1 201 090000 12A 

1201 090001 12A 

1 201 091 000 12A 

1 201091 001 12A 

1 400003000 1 4 

1 40000300 1 14 

1 400004 000 14 

1400004 001 14 

8601000000 86A 

8602000000 868 

Ci tron 

Cit rus hybrids 

Ci trus, oil 

o r ange 

Orange, juice 

Orange, j uice - babyfood 

Or a nge, p eel 

Tangerine 

Tangerine, juice 

Kumquat 

Lemon 

Lemon, juice 

Lemon, juice-babyfood 

Le mon, peel 

Lime 

Lime, jui ce 

Lime, j uice - babyfood 

Pummelo 

Apple, frui t with peel 

Appl e, peeled fru it 

Appl e, _peeled fru it-babyfood 

Appl e, dried 

Apple, dried- babyfood 

Appl e, j u i ce 

App l e, j uice - b a byfood 

App l e, sauce 

Apple, sauce- baby food 

Pear 

Pear-babyfood 

Pear, d ried 

Pear, juice 

Pear, j uice - babyf ood 

Qu i nce 

Cherry 

Cherry- babyfood 

Cher ry, Jui ce 

Cherry, jui ce - babyfood 

Almond 

Almond - babyfood 

Almond, oi l 

Al mond, o i l-babyfood 

Water, d irect, a l l sources 

Water, indi rec t , all sources 

Page 9 of14 

Def Res 

(ppm) 

0 . 500000 

0.500000 

10 . 000000 

0. 500000 

0 . 500000 

0 . 500000 

0.500000 

0. 500000 

0 . 500000 

0.500000 

0.500000 

0.500000 

0.500000 

0 . 500000 

0.500000 

0.500000 

0.500000 

0. 500000 

0.200000 

0.200000 

0.200000 

0.200000 

0.200000 

0 . 200000 

0 . 2000 00 

0 . 200000 

0.200000 

0.200000 

0.200000 

0 . 200000 

0.200000 

0.200000 

0.200000 

2 . 000000 

2 . 000000 

2 .000000 

2 .000000 

0.020000 

0 . 020000 

0 . 020000 

0 . 020000 

0 . 005740 

0.005740 

Adj.Factors 

#1 #2 

1 .000 

1 . 000 

1.000 

1.000 

1 . 000 

1 . 000 

1. 000 

1 . 000 

1 .000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1.000 

1.000 

1.000 

1. 000 

1. 000 

1 . 000 

1 .000 

1 . 000 

8 . 000 

8 . 00 0 

1 .000 

1.000 

1 . 000 

1.000 

1 . 000 

1. 000 

6 . 250 

1.000 

1.000 

1 . 000 

1. 000 

1. 000 

1 . 500 

1 . 500 

1. 000 

1.000 

1 .000 

1. 000 

1.000 

1 . 000 

1. 000 

1. 000 

1 . 000 

1.000 

1 .000 

1 .000 

1 . 000 

1 . 000 

1 .000 

1. 000 

1 . 000 

1. 000 

1. 000 

1. 000 

1 . 000 

1 . 000 

1 .000 

1 . 000 

1.000 

1.000 

1. 000 

1. 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 .000 

1 .000 

1. 000 

1. 0 00 

1 . 000 

1.000 

1 .000 

1 . 000 

1.000 

1.000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 .000 

Comment 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 391808 

Acute Results (food and water) 

U.S. EPA 

DEEM-FCID ACUTE Anal ysis for FENAZAQUIN 

Residue file: FENAZAQUIN acute 060514.R08 

Analysis Date: 07-2 4 -2014/13 :23: 0 5 Residue 

Ve r. 3.16, 03 - 08 - d 

NHANES 2003-2008 2-Day 

Adjustment factor #2 NOT used. 

f i le dated: 07-24 - 201 4/13:18 :06 

RAC/FF intake summed over 24 hours 

Run Comment: " " 

===;=========================================================================== 

Summary calculations- -per capita: 

95th Percentile 99th Percentile 99.9th Percentile 

Exposure % aRfD Exposure % aRfD Exposure % aRf D 

---------- -------- ---------- -------- -- ---- ---- --------

Total us Populati on: 

0.004348 2.90 0. 009613 6.41 0. 0 22713 15 .14 

All I nfants: 

0.007455 4.97 0.01 4127 9.42 0 . 020477 1 3.65 

Children 1 - 2: 

0.015404 10 . 27 0 .028090 18.73 0.053712 35 .81 

Children 3 - 5 : 

0. 011604 7.74 0.021277 1 4 .18 0 . 029986 1 9.99 

Chi ldren 6-12: 

0.006134 4.09 0.012234 8.16 0 .026225 17 .48 

Youth 13-19: 

0 . 00396 5 2.64 0. 007156 4 . 77 0 . 011997 8.00 

Adults 20-49: 

0 . 00298 5 1. 99 0.005448 3.63 0 . 010784 7.19 

Adults 50 - 99 : 

0 . 002568 1. 71 0.004782 3.19 0.008523 5.68 

Femal e 13-49 : 

0.003034 2.02 0.005482 3.65 0 .009022 6 . 01 

Page 10of 14 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 391 808 

Acute Results (water only) 

U.S. EPA 

DEEM-FCID ACUTE Analysis for FENAZAQUIN 

Resi due f ile : FENAZAQUIN acute wa t er onl y.ROS 

Analysis Date: 06-05-2014/15 : 18:42 Residue 

RAC/FF intake summed over 24 hours 

Ver. 3.16, 03-08-d 

NHANES 2003-2008 2-Day 

Ad j ustment factor #2 NOT used. 

file dat ed: 06 - 05-2014/15:10: 4 8 

Run Comment: 11 " 

============== === ============================================================== 

Summary calculations--per capita: 

95th Percent i le 99th Percentile 99.9th Percentile 

Exposure % aRfD Exposure % aRfD Exposure % aRf D 

---------- --- ----- ---------- ------- - ---------- -------- Total us Popul ation: 

0.0003 1 3 0.21 0.000516 0.34 0 . 000980 0 .6 5 

All Infants: 

0.000980 0.65 0 .001328 0 . 89 0.001946 l.30 

Female 13 - 50: 

0.000311 0.21 0.000459 0.31 0.000649 0 . 43 

Children l-2: 

0.000483 0.32 0 . 000727 0 . 48 0.001790 l.19 

Children 3 - 5: 

0 .000392 0.26 0 . 000600 0.40 0.000963 0.64 

Children 6 - 1 2: 

0.000299 0 . 20 0.000491 0.33 0.000757 0 .50 

Youth 1 3-19: 

0.000261 0 . 17 0 . 000429 0 .29 0 . 000648 0 . 43 

Adults 20 - 49 : 

0.000308 0.21 0.000458 0 . 31 0.000667 0.44 

Adults 50 - 99 : 

0 .00027 4 0 . 18 0.000416 0.28 0.000656 0. 44 

Female 13-49: 

0.000312 0.21 0 . 000459 0.31 0.000644 0.43 

Page 11 of 14 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 391808 

Chronic Residue Input File 

Filename: C:\Users\cwall s\Documents\Cassi\HED\Fenazaqui n\dietary\almond 

cherry\FENAZAQUIN CHRONIC 06 0514 .R08 

Chemi cal: fenazaquin 

RfD(Chronic): . OS mg/kg bw/day NOEL(Chronic): o mg/kg bw/day 

RfD(Acute) : . 15 mg/kg bw/day NOEL(Acute): O mg/kg bw/day 

Date created/last modifi e d : 06-05-2014 /15 : 08 : 50 Program ver. 3.16, 03 - 08 - d 

EPA Crop 

Code Grp Commodity Name 

1001106000 lOA 

1 001107000 lOA 

1001108000 l OA 

1001240000 lOA 

1001 241000 lOA 

1001241001 lOA 

1 001242000 lOA 

1001369000 lOA 

1001370000 lOA 

10021 970 00 l OB 

10021 99000 l OB 

1002200000 lOB 

1002200001 l OB 

1002201000 lOB 

1 002206000 lOB 

1002207000 lOB 

100220 7001 lOB 

1003307000 lOC 

1100007000 1 1 

1100008000 11 

1100008001 1 1 

1 100009000 11 

1100009001 11 

110001 0000 1 1 

1100010001 11 

1100011000 11 

1100011001 11 

1100266000 11 

110026600 1 11 

1100267000 11 

1100268000 11 

1100268001 11 

1 100310000 11 

1201 090000 12A 

120 1 090001 12A 

1 201091000 12A 

1201091 001 12A 

1 400003 000 1 4 

1400003001 14 

14000040 00 14 

1400004 001· 14 

8601 000000 86A 

8602000000 868 

Citron 

Citr us hybrids 

Citr us, oil 

Or ange 

Or ange, juice 

Orange, jui ce- babyfood 

Or ange, pee l 

Tangerine 

Tangerine, jui ce 

Kumquat 

Lemon 

Lemon , juice 

Lemon, jui ce-babyfood 

Lemon, peel 

Lime 

Lime, juice 

Lime, j uice - babyfood 

Pumme l o 

Appl e, fruit with peel 

Appl e, peeled fruit 

Apple, peele d fru it-babyfood 

Appl e, d ried 

Apple , d ried- babyfood 

Appl e, jui ce 

Appl e, jui ce - babyfood 

Apple, sauce 

Apple, sauce- babyfood 

Pear 

Pear-baby food 

Pear, d rie d 

Pear, juice 

Pear, j u i ce- babyfood 

Quince 

Cherry 

Cherry- babyfood 

Cherry, Jui ce 

Cherry, jui ce - babyfood 

Al mond 

Al mond - babyfood 

Almond , o i l 

Almond, oil- babyfood 

Water, direct, all sources 

Water, indi rect, all sources 

Page 12of14 

Def Res 

(ppm) 

0 . 50000 0 

0 . 500000 

10.000000 

0 .500000 

0. 500000 

0. 500000 

0. 500000 

0.500000 

0. 500000 

0 . 500000 

0 . 500000 

0 . 500000 

0. 500000 

0. 500000 

0. 500000 

0. 5000 00 

0 . 500000 

0 . 500000 

0 . 200000 

0 .2000 00 

0 . 200000 

0 .200000 

0 .2000 00 

0 . 200000 

0 . 200000 

0 . 200000 

0 . 200000 

0 . 200000 

0 . 200000 

0 .20000 0 

0 . 200000 

0 . 20 0000 

0 . 200000 

2 . 00000 0 

2.000000 

2. 00000 0 

2. 000000 

0.020000 

0.020000 

0:020000 

0. 020000 

0 .002090 

0 .0020 90 

Adj.Factors 

#1 #2 

1 . 000 

1 . 000 

l. 000 

l. 000 

1 .000 

1 .000 

1 .000 

l. 000 

1 .000 

1 . 000 

1 . 000 

l. 000 

1 .000 

l. 000 

1 .000 

1 . 00 0 

1 . 000 

l. 000 

1 . 000 

1. 000 

1 . 000 

8 . 000 

8 . 000 

1 . 000 

l. 000 

1 . 000 

1 . 000 

1 . 0 00 

1 . 0 00 

6.250 

1 . 0 00 

1. 000 

1.000 

1 . 0 00 

1. 000 

1 . 500 

1.500 

1.000 

1.000 

1.000 

1 .000 

1 .000 

1 .000 

1. 000 

1. 000 

1 . 000 

1 .000 

1 .000 

1 . 0 00 

1.000 

1 . 000 

1 . 000 

1. 000 

1 . 000 

l. 000 

1 .000 

1 . 0 00 

1. 0 00 

1. 0 00 

l. 000 

1. 000 

1 .000 

1. 000 

1. 000 

1. 000 

1. 000 

1. 000 

l. 000 

1.000 

1. 00 0 

1. 0 00 

1. 00 0 

1. 000 

1. 000 

1. 000 

1 .000 

1. 000 

1 . 000 

1.000 

1.000 

1. 000 

1 .000 

1 . 000 

1. 000 

1.000 

1.000 

Comment 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 391808 

Chronic Results (food and water) 

U.S. EPA Ve r. 3.16, 03 - 08 - d 

DEEM- FCID Chronic analysis for FENAZAQUIN NHANES 2003-2008 2 -day 

Residue file name : C : \Users\cwalls\ Documents\ Cassi\HED\Fenazaquin\dietary\almond 

cherry\FENAZAQUIN CHRONIC 06051 4.R08 

Ad justment factor #2 NOT used. 

Anal ysis Date 0 7-24-2014/ 13 :20:27 Residue f i le dated: 0 7 - 24-2014/ 13:19 :37 

Reference dose (RfD, Ch ronic) = .05 mg/kg bw/day 

======================================= ====================================== == 

Total exposure by population subgroup 

Population 

Subgroup 

Total US Population 

Hispanic 

Non- Hisp-White 

Non- Hisp- Black 

Non-Hisp-Other 

Nursing Infants 

Non- Nur sing Infants 

Female 13+ PREG 

Children 1-6 

Children 7 -12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13 -50 

Children 1- 2 

Children 3 -5 

Children 6-12 

Youth 13-19 

Adul ts 20 -49 

Adul ts 50-99 

Fema le 13 - 49 

Total Exposure 

mg/kg 

body wt/day 

0.000949 

0.001412 

0 .0008 15 

0. 001145 

0. 0 0107 5 

0.001145 

0 .002138 

0 . 001116 

0.003682 

0 . 001332 

0 . 000828 

0 . 000725 

0.000587 

0.000595 

0.000626 

0.001831 

0.000622 

0 . 004753 

0 . 003358 

0 .001481 

0 .00 07 77 

0.000586 

0 . 000619 

0 . 000613 

Percent o f 

Rf d 

1. 9% 

2.8% 

1.6% 

2.3% 

2.2% 

2.3% 

4.3% 

2.2% 

7 . 4% 

2.7% 

1. 7% 

1. 5% 

1 . 2% 

1 . 2% 

1. 3% 

3.7% 

1.2% 

9.5% 

6.7% 

3.0% 

1.6\ 

1 .2% 

1. 2% 

1. 2% 

-------------------------------------------------------------------------------

Page 13of14 
Fenazaquin Dietary Exposure and Risk Assessment DP Number: 391808 

Chronic Results (water only) 

U.S . EPA Ver. 3 . 16, 03-08-d 

DEEM- FCID Chronic analysis for FENAZAQUIN NHANES 2003 - 2008 2 - day 

Residue fil e name: C:\Users\cwalls\Documents\Cassi\HED\Fenazaqui n\dietary\almond 

cherry\FENAZAQUIN CHRONIC water only.ROS 

Adjustment factor #2 NOT used. 

Analysi s Date 06 - 05 - 2014/15 :13 :13 Residue f ile dated : 06 - 05 - 2014/15 : 09:33 

Reference dose (RfD, Chronic) = .05 mg/kg bw/day 

Total exposure by popul ation subgroup 

Total Exposure 

Popul ation 

Subgroup 

Total US Population 

Hispanic 

Non- Hisp- White 

Non-Hisp-Black 

Non- Hi sp-Other 

Nursi ng Infants 

Non-Nursing Infants 

Female 13+ PREG 

Chi l dren 1-6 

Ch ildren 7-12 

Male 13-19 

Female 13 - 19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13 -50 

Children 1-2 

Children 3-5 

Children 6 - 12 

Youth 13- 19 

Adults 20-49 

Adults 50-99 

Female 13-49 

mg/ kg 

body wt/day 

0 .00004 4 

0 .000042 

0.000045 

0.000036 

0.000050 

0.000040 

0.000146 

0 .000041 

0.000056 

0.000036 

0.000030 

0.000034 

0.000041 

0.000046 

0.000042 

0. 000113 

0.000044 

0.000063 

0.000053 

0 . 000038 

0.000032 

0.000044 

0 .000043 

0.000044 

Page 14 of14 

Percent of 

Rfd 

0 .1% 

0. 1% 

0.1% 

0 . 1% 

0.1% 

0. 1% 

0 . 3% 

0 .1% 

0.1% 

0 . 1% 

0.1% 

0 .1% 

0 .1% 

0 .1% 

0 . 1% 

0.2% 

0 . 1% 

0. 1% 

0 .1% 

0.1% 

0 .1% 

0 .1% 

0 .1% 

0 .1%