### UNITED STATES ENVIRONMENTAL PROTECTION AGENC Y W ASH IN GTO N, D.C. 2 0 4 60



### MEMORANDUM Date: 06/16/2014 OF F ICE OF CHEM I CAL SAFETY AND POLLUTION PRE V ENT I ON



### SUBJECT : Fenazaquin: Acute and Chronic Aggregate D ietary Exposure and Ris k Assessments for the Section 3 Registration Action on Almonds and Cherries. PC Code: 044501 Decisio n No. : 444200 Petition No . : l F7825 R i sk Assessm ent Type: Dietary TXRNo.: NA MRIDNo. : NA DP Barco d e: D391808 Registration No
. : 10163-295; 10163

- GEE Regu latory Action: Section 3 Registration Case No.: NA CAS N o . : 120928 -0 9-8 40 CFR: § 1 80 .632 FROM : Cassi Wall s, Ph.D., Senior Biologist

### ~ t. 

# t)ol/b. Risk Assessment Branch III H ealth Effects Divisio n (HED, 7509P) THROUG H: Sheila Piper, Chemist

# 8~**()_~** r ti\. ,

# ~ Mohsen Sahafeyan, Chemist ·**~** 

### Dietary Exposure S c ience Advisory Council (DESAC) TO: Olga Odiott, Risk Manager Reviewer Insecticide and Rodenticide B ranch Registration Division (7505P)

Executive S u m m ary Acute and chronic agg r egate die tary food and drinking water exposure and ri sk assessments were conducted u sing the D ietary Expos ure E valu ation Model software with the Food Commod ity Intake Da t abase (DEEM-FCID) Version 3
. 16. This software uses 2003-2008 food co n sum p tion data from the U.S. Department of Agriculture 's (USDA's) National Health and Nutrition Examination Survey, What We Eat in America, (NHANES /WWEIA). The analyses were conducted in support of a human-health risk assessment for the proposed Section 3 uses of fenazaquin on almo nd s and cherries. This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 20 12.1. Page I of 1 4Fenazaquin Dietary Exposure and Risk Assessment DP Number : 391808



### Acute Dietary Exposure Assessment The acute dietary risk assessment is a conservative evaluation based on proposed to lerance level residues for almond s and cherries and on current to lerances for imported commodities (e
.g., apples, p ears, and citrus fruit) with the ass u mption that 100% ofthe crops are treated with fenazaquin. DEEM 7 .81 d efault processing factors were utilized for imp orted commodities and almonds an d cherries
. The acu te d ietary assessments using th e DEEM -F C ID TM Model were reported at the 95th percentil e of exp osure for the general U.S. population and all of its subgroups. Risk es timates were all well below 100% of the ac u te Popul ation

- Adjusted Dose (aPAD) thres h old level of concern. Fenazaquin acute dietary exposure for food and water was estima ted to be 0
. 0043 mg/kg/day at 3% of the aPAD for the general U.S
. popul ation . Acute d ietary exposure of food and water for the most highly exposed population subgroup, children 1

-2 years of age, was es timated to be 0
.015 mg/kg/day at 10% ofthe aPAD
. Chronic Dietary Exposure Assessment The chronic dietary risk assessment is a conservative evaluation based on prop osed toleran ce level residues for almonds and cherries and on current tolerances for imported commodities (e.g., apples, pears, and citrus fruit) with th e assum ption that 100% of the crops are treated w ith fenazaqu in . DEEM 7
. 81 default processing fac tors were uti li zed for the imported commodities an d almonds and cherries. Risk estimates were all found to be well b elow 100% ofthe chronic Population

- Adjusted Dose (c PAD) thres h old level of concern. Fenazaquin chronic dietary exposure of food and water was es timated to be 0.00095 mg/kg/day at 2% ofthe cPAD for the general U.S. population . In comparison, chronic die tary exposure from food and water for the most highly exposed popul ation subgroup, chil dren 1-2 years of age, was estim ated to be 0.0048 mg/kg/day at 10% of the cPAD. 

### I . Introduction Dietary risk assessment incorporates both exp osure and toxicity of a given pesticide
. For acute and chronic assessme n ts, the risk i s expressed as a percentage of a maximum accep table dose (i .e., the dose that HED has concluded w ill result in no unreasonable adverse health effects). This dose is referred to as the popul ation-adjusted dose ( PA D). T he PAD is equivalent to th e po int of departure (POD, NOAEL, L OAEL, e.g . ) divided by the required uncertainty or safety factors. For acute and non - ca n cer chronic exp osures, HED i s concerned when estimated d ietary risk exceeds 100% ofthe PAD. R eferen ces that discuss the acute and chronic risk assessm ents in more detail are avail able on the EPA/pest icides web site: " Availab le Information on Assessi n g Expos ure from Pe sticides, A User's Guide," 06/21/00, web link :

Page 2 of 14Fenazaquin Dietary Exposure and Risk Assessment DP Number: 39 I 808 

### http: //www.epa.gov/ fedrgstr/EPA -PEST /2000/July/Day-12/ 6061.pdf; or see SOP 99.6 (08/20/99)
. The most recent dietary risk assessment for fenazaquin was conducted by Debra Rate (10/27/08, DP344660).


### II. Residue Information Fenazaquin is a quinazoline class insecticide /acaricide formulated by the Gowan Company for the control of mites and white flies on crops in various parts of the world. Tolerances have been established for fenazaquin, or 4-tert

- butylphenethyl quinazoli n- 4

-yl ether, on the imported commodities apple, citrus oil, citru s fruit crop g roup 10 except grapefruit , and pear (40 CFR 180.632). The current petition proposes the first food uses for fenazaquin on US domestic crops of almonds and cherries. Metabolism studies were conducted using [ 14

### C]fenazaquin on both apples and oranges, as well as on dairy goat ruminants (MRID Nos. 45029914 & 

### 45029915, 4505440 I, and 45029916). The metabolism of fenazaquin in plants and animals is understood based upon this data. The tole rance expression for the residue of concern in plant and animal commodities is parent fenazaquin. The acute and chronic dietary analyses assume that fenazaquin residues are in/on all registered and proposed food commodities at tolerance levels. The established and recommended tolerances levels used in the dietary analyses are summarized in Table 1
. Table 1. Summary for Fenazaquin Residue Levels Used in Acute and Chronic Dietary Analyses Established Recommended Commodity Tolerance Tolerance (ppm) (ppm) 

### Apple 

### 0.2 NA Pear 

### 0.2 NA Cit rus fruits , except grapefruit 

### 0.5 NA Citrus Oil 

### 10.0 NA Almond NA 

### 0.02 Cherry NA 

### 2.0 Ill. Percent Crop Treated Information For both the acute and chronic dietary assessments, it was assumed that 100% of all the raw agricultural commodities (RACs) consumed domestically are treated with fenazaquin
.

Page 3 of 14Fenazaquin Dietary Exposure and Risk A ssessment DP Number: 391808


### IV. Drinking Water Data The drinking water residues used in the dietary risk assessment were provided by the Environmental Fate and Effects Divi sion (EFED) in the following memorandum: "Drinking Water Assessment to Support First Fenazaquin (4-tert-butylphenethyl quinazo li n-4-yl ether) Use on Food Crops" (D394030, James Hetrick, 03 /08/ 12) and incorporated directly into this dietary assessment. Water residues were incorporated in the DEEM-FCID into the food categories "water, direct, all sources" and "water, indirect, all sources." The drinking water assessment was conducted using the total toxic residue (TTR) approach. The residues considered in this assessment include fenazaquin (parent),4-(2-( 4-(1, 1- imethylethyl)phenyl)ethoxy)quinazolone (Metabolite 1 ), and 2-Methyl-2

- ( 4

- {2-[(2-oxo-1,2- dihydroquinazol in-4-yl)oxy ]ethyl }phenyl) propanoic ac id (Metabolite 2). The modeling for fenazaquin and its degradation products was conducted using a total residue approach. Tier I groundwater estimated drinking water concentrations (EDWCs) were calculated using SCI-GROW**(~creening** 

### Concentration in Groundwater, version 2.3, August 8, 2003)
. Tier II surface water EDWCs were calculated using PRZM (£.esticide Root Zone Model, version 3.12.3, June 2006) and EXAMS (EXposure Analysis Modeling**~stem,** 

### version 2.98.04.06, April 2005) models in the PE5 shell. All Tier II surface water modeling was correc ted for default percent cropped area (PCA) of 0.87
. For additional details on the modeling, refer to http: //www .epa.gov/oppefed 1 /model s/water/. For the proposed almond and cherry uses of fenazaquin , the Tier II surface water modeling showed that concentrations of fenazaquin residues are not expected to exceed 5
. 74 μg/L for a 1 in 10 year daily peak, 2
. 09 μg/L for 1 in 10 year annual average, and 1.33 μ g/L for the 30 year annual average. Tier I ground water modeli ng indicates the fenazaquin residue concentrations are not expected to exceed 0.0704 μg/L for peak and long-term average concentrations. No monitoring data are available to assess fenazaquin concentrations in ground and surface waters . A summary ofthe recommended EDWCs (5.74 ppb for acu te and 2.09 ppb for chronic) used in the dietary analyses is presented in Table 2. Table 2. Estimated Drinking Concentrations for To tal T oxic Residues of Fenazaquin in Su rface and Ground Source Water from Proposed Fe nazaquin Uses l in 10 year Concentration Scenario Peak (acute) Surface M l cherries; water a aerial aoo 5.74 Ground water b • From the Tier II PRZM-EXAMs modeling system. b From the Tier I SCI-GROW model. Bolded values were used in the dietary analyses. (u J/L) Annual Average (non-cancer chronic) 2.09 0.0704

Page 4of14 30 year Annual Aver.age (μg/L) (cancer)
1.33Fenazaquin Dietary Ex posure and Risk Assessment DP Number: 39 1808



### V. DEEM-FCID Program and Consumption Information Fenazaquin acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3.16, which incorporates 2003-2008 consumption data from USDA's NHANES /WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days. Foods " as consumed " (e.g., apple pie) are linked to EPA-defined food commodities (e.g., apples , peeled fruit

- cooked; fresh or N/ S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicl y available recipe translation file s developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. However, for acute exposure assessment, consumption data are retained as individual consumption events. Based on analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns a nd survey respondents, HED concluded that it i s most appropriate to report risk for the fo llowing population s ub groups: the general U.S. population, all infants (< l year old), children 1-2 , children 3-5 , children 6-12, youth 13-19 , adults 20-49, females 13-49 , and adults 50-99 years old. For a chronic dietary exposure assessment , an estimate ofthe resi due lev e l in each food or food

form (e.g., orange or orange juice) on the food commodity residue list i s multiplied by the average daily consumption estima te for that food/food form to produce a re s idue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure . Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. For an acute exposure assessment, individual one -d ay food consumption data are used on an individual-by-individu al basis. The reported consumption amounts of each food item can be multiplied by a re s idue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or " matched" in multip le random pairings with residue values and then summed in a probabilis tic assessment. The resu lti ng di stribution of expos ure s is expressed as a percentage of the aPAD on both a user (i.e. , only those who reported eating relevant commodities/food forms) and a per- capita (i.e., those who reported eating the relevant commodities as well as those who did not) basis. In accordance with H ED policy, per capita exposure and ri sk are reported for analyses performed at all le v els of refinement. Ho wever , for determ ini stic assessments , any significant differences in user vs. per capita exposure and risk are specifically identified and noted in the risk asses s ment. 

### VI. Toxicological Information A ll information specific to the fenazaquin toxicol ogical profile is presented in the risk assessment document for this petition (DP Number 389845)
. Acute and chronic dietary endpoints were selected based on fenazaquin toxicity study results. For acute dietary exposure , the results from the immunotoxicity study were considered 

### in selecting toxicity endpoints and points of departure (POD ) for risk assessment. The NOAEL of 15 mg/kg/day was selected as the POD based on clinical signs (i.e. general ataxia/hypoactivity) observed after a single exposure at

Page 5of 14Fenazaqui n Di etary Exposure and Risk Assessment DP Number: 391808


### the lowest observed adverse effect level (LOAEL) of 30 mg/kg/day. The endpoint is appropriate for this exposure scenario since the effects were seen after a s ing le oral administration. In addition, it is also protective of the effects seen in t he acute neurotoxicity study at 60 mg/kg (LOAEL). An acute reference dose (aRfD) of 0.15 mg/kg/day was derived from the no observed adverse effect level (NOAEL) with the application of an Uncertainty Factor of I OOx (1 OX interspecies extrapolation, 1 OX intra-species variations factor). A separate endpoint of concern for pregnant females ( 13

- 49 years of age) was not selected s ince no endpo ints attri butable to a single dose were identified in the deve lopmental toxicity studies in rats and rabbits
. For chronic dietary exposure, the toxicity endpoints of decreases in body w e ight, food consumpti on , and food efficiency were selected, and these effects were seen at simi l ar dose level s in both subchronic (15 mg/kg/day) and chronic oral toxicity studies in dogs (12 mg/kg/day). The NOAELs were the same for both chronic and subchronic toxicity studies in dogs. The results from these two studies demonstrated no increase in severity w ith increased treatment durations. Hence, the subchronic and chronic toxicity studies in dogs were appropria te to be employed as co - cr itical studies for toxic ity end point and point of departure selections for the chronic exposure scenario. A chronic reference dose (cRfD) of 0.05 mg/kg/day was derived from a NOAEL of 5 mg/kg/day and an UF of 1OOx. The lOX FQPA Safety Factor can be reduced to IX because the toxicity database is complete , there is no evidence of sensitivity/susceptibili ty in the developing organism, no neurotoxicity, and no residual uncertainty in the exposure data. A summa ry of the doses and tox icological endpoints selected fo r the dietary exposure scenarios which were perfonned are provided in Table 3. Table 3. Toxicological Doses and Endpoints for Fenazaquin for Use in Dietary Health Risk Assessments.

Exposure/ Point of Uncertainty/ Scenario Departure FQPA Safety RfD,PAD Study and Toxico logical Effects (POD) Fac tors Acute Dietary NOAEL= UFA= !Ox aRfD = 0.15**lmmunotoxici~** - Rat (General 15 mg/kg/day UFH= !Ox mg/kg/day LOAEL = 30 mg/kg/day population) FQPA SF= Ix Based on cl i nical signs (general aPAD = 0
. 15 ataxia/hypo -acti vity) observe d in I mg/kg/day animal on Day 02 and 3 animals on Day 03 of dosing. Chronic NOAEL

- UFA= !Ox cRfD = 0.05 Co-Critical: Subchronic and Chronic Dietary (All 5 mg/kg/day UFH= !Ox mg/kg/day Toxicity

- Dog Populations) FQPA SF= Ix cPAD = 0.0 5 Subchronic Toxicity

- Dog m

g/kg/day LOAEL = 15 m g/kg/day Based on decreased body weight, body weight gain , and food consumption/efficiency. Chronic Toxicity

- Dog LOAEL = 12 mg/kg/day Based on decreased body weight, body weight gain, and food consumption /efficiency
Page 6of14Fenazaquin Di e tary Ex posure and Ri s k Assessment DP Number: 39 1808

Table 

### 3. Toxicological Doses and Endpoints for Fenazaquin for Use in Dietary Health Risk Assess ments. Point of U ncertainty/

Exposure/ Sce nario Departure FQPA Safety RfD, PAD Study and Toxicological Effects (POD) Factors Ca ncer (oral, Classifi cation: "Not likely to be Carcinogenic to I Ju man s" based on the absence of significant tumor increases dermal , in two adequate rode nt carcinogenicity studies. inhalation) Point of Departure (POD) = A data point or an estimated point that 1s derived from observed dose

- response data and used to mark the beginning of extrap olation to determine risk associated with lower envi ronmentally relevant human exposures. NOAEL
= no observed adverse effect l evel. LOAEL = lowest observed adverse effect level. UF = uncertainty factor. UFA= extrapolation from anima l to human (interspecies). U FH =potentia l variation in se nsitivity amo ng memb ers of the human population (intraspecies). FQPA SF= FQPA Safely Factor. PAD = population adjuste d dose (a = acute, c =chronic). RID = referen ce dose
. 

### VII
. Results/Discussion 

### As stated above, for acute and chronic assessments , HED is concerned when dietary risk exceeds 100% ofthe PAD. The DEEM-FCID analyses estimate the dietary exposure and risk ofthe U.S. population and vari ous population subgroups. T he re s ults reported in Tab le 4 are for the general U.S. Population , a ll infants (< l ye ar old) , children 1- 2, children 3-5 , chi ldren 6-12 , youth 13-19 , females 13

-49 , adults 20-49, and adults 50-99 years. Cancer risk is determined for the general U.S. population only. Results of Acute and Chron ic Dietary (Food and Drinking Water) Exposure and Risk Analysis Acute and chronic dietary risk analyses were conducted with the DEEM-FCID model using conservative exposure a ssumptions for fenazaquin. The acute dietary results at the 95th percentile indicate risk estimates are reasonabl y below the 100% of the aPAD threshold level of co ncern for each popul at ion subgroup. The acute dietary risk for the U.S
. population was est imated to be 3% of the aPAD with an exposure of 0.004348 mg/kg/day. For the most highly exposed population subgroup, children 1-2 years of age, acute dietary ri s k was estimated to be 10% of the aPAD with an exposure of 0.015404 mg/kg/day. Additionally , chronic analysis yielded risk estimate s well be low the l 00% of the cPAD thres ho ld level of concern fo r each population subgroup. The chronic dietary risk for the U.S. population w as estimated to be 2% of the cPAD with an exposure of0.000949 mg/kg/day. For children 1-2 years of age, chronic dietary risk is estimated to be 10% of the cPAD with an exposure of0.004753 mg/kg/day. An 

### overv ie w summar izi n g the res ults ofthe acu te and chronic dietary assess ments w ith the population subgroup having the highest exposure being noted in bold is presented in Table 4.

Table 4. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Fenazaquin. Acute Dietary Chronic Dietary Cancer (95th Percentile) Popul atio n Subgroup Dietary Dietary Dietary Expos ure % aPAD* Ex po s ure % cPAD* Expos ure Risk ( mg / kg/day) (m!?/k!?/dav) (mg / ki!/day) General U.S
. Populatio n 0.0043 48 3 0.000949 2 All In fants (<I year old) 0
. 007455 5 0.00 1831 4 

### N /A N/A Chil dren 1-2 year s old 0.0 15404 10 0.004 753 10 C hildre n 3-5 ye ars old 0.01 160 4 8 0.003358 7

Page 7of14Fenazaquin Dietary Exposure and Risk Assessment DP Numb er: 391808


### T able 4
. S umm ary of Dieta ry (Food and Drinking Water) Exposure and Ris k fo r Fenaz aquin. Acute Di e tary 

### Chronic Dieta r y 

### C anc er (95th Perc e ntile) P opula t ion S ubgroup Diet ary Dietar y Di et a r y E xposure % aPAD* Expos ure % cPAD * Expos ure Risk (mg/kg/ da y) (mg/kg/day) (m:g/kg /day) Children 6-12 years old 0 .006 134 4 0.001481 3 Youth 13-19 years old 0.003965 3 0
. 000777 2 Adults 20-49 years old 0. 002985 2 0.000586 I Adults 50-99 years old 0.002568 2 0 .000619 I Females 13-49 years old 0.003034 2 0.000613 I *The subpopulation with th e highest ri s k e s timate s 

### VIII. Characterization of Inputs/Outputs The acute and chronic dietary exposure and risk analyses are based on tolerance-level residues, 100% crop treated assumptions, and defau lt processing factors. Various refi nements could be made to the assessments. However, as there are no risk estimates of concern, no refinements were incorporated
. 

### IX
. Conclusions The conservative acute and chronic dietary risk assessments conducted with DEEM

-FCID indicate that food and drinking water exposures to fenazaquin are well below HED's level of concern. The resulting acute risks for fenazaquin are reported at the 95th 

### percentile of exposure for the general U
. S. population and all of its subgroups. Acute dietary exposure to fenazaquin was estimated to be 3% of the aPAD for the general U .S. population. Chronic dietary exposure to fenazaquin was estimated to be 2% of the cPAD for the general U
. S. population. For the most highly exposed population subgroup , children 1-2 years of age , both acute and chronic dietary exposures were estimated to be well below HED's level of concern. For this subgroup, the acute exposure was 10% ofthe aPAD and the chronic exposure was 10% ofthe cPAD.


### X. List of Attachments
• • • 

### • • 

### • Acute Residue Input File Acute Results (food and water) File Acute Results (water on ly) File Chronic Residue Input File Chronic Results (food and water) File Chronic Results (water only) File

Page 8 of 1 4Fenazaq ui n Dietary Exp osure and Ris k Asse ssm ent D P Number: 391 8 08


### Acu te Residue Input Fil e Fi l enam e : C:\Users\cwa l ls\Docum en t s\Cassi\HED\Fenazaquin\dietary\almond cher r y\FENAZAQUIN acute 0 60514 .R08 Chemica l : f ena z a qu in RfD(Chronic): .05 mg/kg bw/day N OEL(Chr onic): O mg/kg bw/day RfD{Acute):
. 15 m g/kg bw/day NOEL(Acute): O mg/ k g bw/day Da t e c r eated/last mod i fied : 06-05-2014/15:10:1 4 P r ogram ver. 3.16, 03-08-d Crop EPA Code G r p Co m modi t y Nam e 1 00 11 06000 lOA 1 001107000 l OA 1 0 0 1 108000 lOA 100 1 2 4 0000 lOA 10012 41 000 lOA 1 0012 41 00 1 lOA 1 00 1 242000 l OA 100 1 369000 l OA 1 001370000 lOA 1002197000 108 1 002 1 990 0 0 108 1 002200000 1 08 1002200001 l OB 100220 1 000 lOB 1 002206000 108 1002207000 108 100220700 1 108 1 003307000 lOC 1 1 00007000 11 1100008000 11 1100008001 11 1100009000 11 1100 0 0900 1 11 1100010000 11 11 00010001 11 11 00011000 11 1100011001 11 1100266000 11 11 00266001 11 11 00267000 11 1100268000 11 110026800 1 11 1100310000 11 1 20 1 090000 12A 1 20 1 09000 1 12A 1 20 1 09 1 000 12A 1 20 1 09 1 001 12A 1 400003000 1 4 1 40000300 1 14 1 4 0000 4 000 14 1 4 0000 4 001 14 8601000000 86A 8602000000 868 C i tron Ci t rus hybrids C i trus, oil o r ange Orange, juice Orange, j uice

- babyfood Or a n ge, p ee l Tange ri ne Tangerine, juice Kumquat Le m on Lemon, juice Le m on, juice-babyfood Le m on, peel Li m e Lime, ju i ce Li m e, j uice

- babyfood P u m melo Apple, fru i t with pee l App l e, peeled fru it App l e,

_ peeled fru it-babyfood App l e, dried Apple, dried

- babyfood App l e, j u i ce App l e, j uice

- b a byfood App l e, sauce Apple, sauce - baby food Pear Pear-babyfood Pear , d ried Pear, juice Pear, j uice

- baby f ood Qu i nce Cherry Cherry

- babyfoo d Che r ry, Ju i ce Cherry, ju i ce - babyfood Al m ond Almon d

- babyfood Al m ond, oi l Al mo n d, o i l-babyfood Water, d irect, a l l so ur ces Water, ind i rec t , al l sources

Page 9 of14 Def Res (ppm) 0
. 500000 0.500000 10
. 000000

0. 500000 0
. 5000 0 0 0
. 500000 0.500000 0. 5 00000 0
. 500000 0.50 0 000 0.500000 0.500000 0.500000 0
. 500000 0.5000 0 0 0.500000 0.500000 0. 5 00000 0.200000 0.200000 0.200000 0.200000 0.200000 0
. 200000 0
. 2000 0 0 0
. 200000 0.200000 0.200000 0.200000 0
. 200000 0.20 0 000 0.2000 0 0 0.200000 2
. 000000 2
. 000000 2 .0 00000 2 .0 00000 0.020000 0
. 020000 0
. 020000 0
. 020000 0
. 005740 0.005740 Adj.Factors # 1 #2 1 .000 1
. 000 1.00 0 1.000 1
. 000 1
. 000 1. 000 1
. 000 1 .000 1
. 000 1
. 000 1
. 000 1.000 1.000 1.000 1.000 1. 000 1. 000 1
. 000 1 .0 00 1
. 000 8
. 000 8
. 00 0 1 .000 1.000 1
. 000 1.000 1
. 000 1. 000 6
. 250 1.000 1.000 1
. 000 1. 000 1. 000 1
. 500 1
. 500 1. 000 1.000 1 .000 1. 000 1.000 1
. 000 1. 000 1. 000 1
. 000 1.000 1 .000 1 .000 1
. 000 1
. 000 1 .000 1. 000 1
. 000 1. 000 1. 000 1. 000 1
. 000 1
. 000 1 .000 1
. 000 1.000 1.000 1. 000 1. 000 1.000 1
. 000 1
. 000 1
. 000 1.000 1 .000 1 .000 1. 000 1. 0 0 0 1
. 000 1.000 1 .000 1
. 000 1.000 1.000 1
. 000 1.000 1
. 000 1
. 000 1
. 000 1 .000 CommentFenazaquin Dietary Exposure and Risk Assessment DP N umber: 391808


### Acute Results (food and water)
U.S. EPA DEEM-FCID ACUTE Ana l ysis for FENAZAQUIN Residue file: FENAZAQUIN acute 060514.R08 Analysis Date: 07-2 4 -201 4/13 :23: 0 5 Residue Ve r. 3.16, 03

- 08

- d NHANES 2003-2008 2-Day Ad ju stment factor #2 NOT used. f i le dated: 07-2 4

- 20 1 4/13:18 :06 RAC/FF intake summed over 24 hours Run Com m

ent: " " 

### ===;========= =================================== ====== ========================= Summary calculations

- -per capita: 95th Percentile 99th Percentile 99.9th Percen til e Exposu re % aRfD Exposure % aRfD Exp os ure % aRfD



### ---------- -------- 

### ---------- -------- 

### -- -- -- -- -- -------- Total us Populat i on: 0.004348 2.90 0. 0 09613 6.4 1 0. 0 22713 15 .1 4 All I nfan ts: 0.007455 4.97 0.0 1 4127 9.42 0
. 020477 1 3.65 Children 1

- 2: 0.015404 10
. 27 0 .02809 0 18.73 0.0537 12 3 5 .8 1 Children 3

- 5 : 0. 011604 7.74 0.02 127 7 1 4 .18 0
. 029986 1 9.99 Chi ldren 6-12: 0.006134 4.09 0.012234 8.16 0 .02622 5 17 .48 Youth 13-19: 0
. 00396 5 2.64 0. 007156 4
. 77 0
. 011997 8.00 Adults 20-49: 0
. 00298 5 1. 99 0.005448 3.63 0
. 010784 7.19 Adults 50

- 99 : 0
. 002568 1. 71 0.004782 3.19 0.008523 5.68 Fema l e 13-49 : 0.003034 2.02 0.005482 3.65 0 .00 9022 6
. 01

Page 10of 14Fenazaquin Dietary Exposure and Risk Assessment DP Number: 391 8 08


### A cute Results (water only)
U.S. EPA DEEM-FCI D A C

UTE Analysis for FE N AZAQUI N Res i due f il e : FENAZAQUIN acute w a t er on l y.ROS Analysis Date: 06-0 5-201 4/ 15 : 18:42 Residue RAC/FF intake su m med ove r 24 hours Ver
. 3.16, 03-08-d N

HANES 2003-2008 2-Day Ad j ustment factor #2 N OT us ed. file da t ed: 06

- 05-2014/15:10: 4 8 Run Comment: 11 " 

### =

=== ====== = === === ===== ======= = ===== ========================================== == Summary calculations--per capit a: 95th Percen t i le 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD



## ---------- --- - --- - 

## ------ --- - -- ---- - - 

## - --------- 

## --- ---- - Total 

### us Popu l ation: 0.0003 1 3 0.21 0.000516 0.3 4 0
. 000980 0 .6 5 All Infants : 0.000980 0.65 0 .001328 0
. 89 0.001946 l.30 Female 13

- 50: 0.000311 0.21 0.000459 0.31 0.000649 0
. 43 Children l-2: 0.000483 0.32 0
. 000727 0
. 48 0.001790 l.19 Children 3

- 5: 0 .00 0392 0.26 0
. 000600 0.40 0.000963 0.64 Children 6

- 1 2: 0.000299 0
. 20 0.000491 0.33 0.000757 0 .5 0 Youth 1 3-1 9: 0.000261 0
. 17 0
. 000429 0 .2 9 0
. 000648 0
. 43 Adults 20

- 49 : 0.000308 0.21 0.000458 0
. 31 0.000667 0.44 Adults 50

- 99 : 0 .0 0027 4 0
. 18 0.000416 0.28 0.000656 0. 4 4 Female 13-49: 0.000312 0.21 0
. 000459 0.31 0.000644 0.43

Page 11 of 14Fenazaquin Dietary E xposure and Risk Assessment DP Number : 391808 

### Chronic Residue Input File Filename: C:\Users\cwal l s\Documents\Cassi\HED\Fenazaqu i n\ dietary\al m ond cherry\FENAZAQUIN CHRONIC 06 0 514 .R08 Che m i ca l: fena zaquin RfD(Chronic):
. OS m g/ k g bw/day NOEL(Chronic): o mg /kg bw/day RfD(Acute) : . 15 mg/kg bw/ day NOEL(Acute): O mg/kg bw/day Date created/last m od if i e d : 06-05-201 4 /15 : 08 : 50 Prog ram ver. 3.16, 03

- 08

- d Crop E P A Code Grp Commodity Name 100 1 106000 lOA 1 001107000 lOA 1001108 000 l OA 100 1240000 lO A 100 1 24 10 00 lOA 10 01241001 lO A 1 00 1242000 lO A 1001369000 lO A 1001370000 lO A 10 02 1 970 00 l OB 10 02 1 99000 l OB 100 2200000 lOB 1002200001 l O B 100220100 0 lOB 1 002206000 lOB 1 002207000 lO B 10 0220 700 1 lOB 1003307000 lOC 110000 70 00 1 1 1100008000 11 110000800 1 1 1 1 100009000 11 1100009001 11 110 0 01 00 00 1 1 1100010001 11 1100011000 11 110 0 01100 1 11 110 02660 00 11 110 02660 0 1 11 1100267000 11 1100268000 11 1100268001 11 1 1 00310000 11 120 1 090000 12A 12 0 1 090001 12A 1 201091000 12A 12 01091 00 1 12A 1 400003 00 0 1 4 1400003001 14 140000 40 00 14 140000 4 001· 14 860 1 000000 86A 8602000000 868 Citro n Cit r us hyb ri ds Cit r us, oil O

r ange O

r ange, juice O

ra nge, ju i ce - baby fo od O

r ange, pee l Tangerine Tangerine, ju i ce K

u m quat Le m on Le mon , juice Lemon, ju i ce-babyfood Lemon, peel Lime Lime, juice L ime, j uice

- babyfood Pumme l o App l e, fruit with peel App l e, peeled fruit App le, peel e d fr u it-babyfood App l e, d ri ed App le , d ri ed

- bab yfoo d App l e, ju i ce App l e, ju i ce - bab yfoo d App le, sauce Apple, sauce - babyfood Pear Pear-babyfood Pear, d ri e d Pear, juice Pear, j u i ce - babyfood Qui n ce Cherry Cherry

- b abyfood Cher ry, Ju i ce Cherry, ju i ce - babyfood Al mo n d Al mo n d

- babyfood Al mo n d , o i l Almond, oil

- baby foo d Water, direct, all sources W

ater, ind i rect, all sources

Page 12of14 Def Res (ppm) 0
. 500 00 0 0
. 500000 10.000000

0 .5 00000 0. 5 00000 0. 5 00000 0. 5 00000 0.500000 0. 5 00000 0
. 500 00 0 0
. 500 00 0 0
. 500000 0. 5 00000 0. 5 00000 0. 5 00000 0. 50 00 00 0
. 500000 0
. 5000 0 0 0
. 200000 0 .20 00 00 0
. 20 0000 0 .20 0000 0 .20 00 00 0
. 2 0 0000 0
. 200000 0
. 200000 0
. 200000 0
. 200000 0
. 200000 0 .20 000 0 0
. 200000 0
. 20 0000 0
. 200000 2
. 00000 0 2.000000 2. 00000 0 2. 000000 0.020000 0.020000 0:020000 0. 020000 0 .00 2090 0 .00 20 90 Adj.Factors #1 #2 1
. 00 0 1
. 000 l. 000 l. 000 1 .000 1 .000 1 .00 0 l. 00 0 1 .00 0 1
. 000 1
. 000 l. 000 1 .0 00 l. 000 1 .0 00 1
. 00 0 1
. 000 l. 000 1
. 000 1. 000 1
. 000 8
. 000 8
. 000 1
. 000 l. 000 1
. 000 1
. 000 1
. 0 00 1
. 0 00 6.2 50 1
. 0 00 1. 000 1.000 1
. 0 00 1. 000 1
. 500 1.500 1.000 1.00 0 1.000 1 .00 0 1 .000 1 .000 1. 000 1. 000 1
. 000 1 .000 1 .000 1
. 0 0 0 1.000 1
. 000 1
. 000 1. 000 1
. 000 l. 000 1 .000 1
. 0 00 1. 0 0 0 1. 0 00 l. 000 1. 000 1 .000 1. 000 1. 000 1. 000 1. 000 1. 000 l. 000 1.000 1. 00 0 1. 0 00 1. 00 0 1. 000 1. 000 1. 000 1 .00 0 1. 000 1
. 000 1.000 1.000 1. 000 1 .000 1
. 000 1. 000 1.000 1.000 Comm entFe nazaquin D ietary Expo s ure and Ris k Assessment DP Number: 39180 8 

### Chroni c Results (food and water)

U.S. EPA V e r. 3.16, 03

- 08

- d DEEM

- FCID Chronic ana lysis for FENAZAQUIN NHANES 2003-2008 2 -da y Residue file name : C : \Users\cwa lls \ Documents \ Cassi \HED\Fenazaquin\dietary\almond ch erry \FENAZAQUI N CHRONIC 06051 4.R08 Adjustment facto r # 2 NOT used. A

na l ysis Date 0 7-24-2014/ 13 :20:27 Residue f i le dated: 0 7

- 24-20 14 / 13:19 :37 R

eference dose ( RfD, Ch ronic) 

## = .05 mg /kg bw/d ay 

### == === = ======= ======= ========== == ==== === ========= ====== ======= == === ==== == == === == Total exposu re by population subgroup

Popu lation

Subgroup Total US Population Hispanic Non- Hisp-White Non

- Hisp

- Black No n-Hisp-Other Nursing Infants Non

- Nu r sing Infan ts Female 13 + PREG Children 1-6 Children 7 -12 Male 13-19 Female 13-19/NP Male 20+ Fe m ale 20+/ NP Seniors 55+ All Infants Female 13 -50 Children 1

- 2 Children 3 -5 Children 6-12 Yo uth 13-19 Adu l ts 20 -49 Adu l ts 50-99 Fema le 13

- 49 Total Exposu re mg/kg body wt/day 0.000949 0.001412 0 .0008 1 5 0. 00 1145 0. 0 01 07 5 0.00114 5 0 .0 02138 0
. 00 1 116 0.003682 0
. 001332 0
. 000828 0
. 000725 0.000587 0.000595 0.000626 0.00 1831 0.000622 0
. 00 4753 0
. 003358 0 .0 0 14 81 0 .0 0 07 77 0.000586 0
. 000619 0
. 000 613 Percen t o f Rf d 1. 9% 2.8% 1.6% 2.3% 2.2% 2.3% 4.3% 2.2% 7
. 4% 2.7% 1. 7% 1. 5% 1
. 2% 1
. 2% 1. 3% 3.7% 1.2% 9.5% 6.7% 3.0% 1.6\ 1 .2 % 1. 2% 1. 2%



## - ---- -- - --- - -- -- - --- -- ----------- ----- -- -------- ----- -- - -------- ----- - -- -------

Page 13of14Fenazaquin D ietary Exposure and Risk Assessment DP Number: 391808 

### Chronic Results (water only) U.S
. EPA Ve r. 3
. 16, 03-08-d DEEM

- FCID Chronic analysis for FENAZAQUIN NHANES 2003

- 2008 2

- day Res idue fi l e name: C:\Users\cwalls\Documents\Cassi\HED\Fenazaqu i n\dietary\almond cherry\FENAZAQUIN CHRONIC water only.ROS Adjustment factor #2 NOT used. Analys i s Date 06

- 05

- 20 1 4/ 1 5 :1 3 :1 3 Residue f ile dated : 06

- 05

- 2014/15 : 09:33 Refe rence dose (RfD, Chronic) 

### = .05 mg/kg bw/day Total exposure by popu l ation subgroup
Total Exposure Popu l ation

Subgroup Total US Population Hispanic Non

- Hisp

- White Non-Hisp-Black Non- Hi sp-Other Nurs i ng Infant s N

on-Nursing Infants Fe m ale 13 + PREG Chi l dren 1-6 C

h ildren 7-12 Male 13-19 Fe m ale 1 3

- 19/NP Male 20+ Female 20+/NP Seniors 55+ All In fan ts Fem ale 13 -5 0 Chil dren 1- 2 Children 3-5 Children 6

- 12 Youth 1 3- 1 9 Adults 20-49 Adults 50-99 Female 13-49 mg / kg body wt/day 0 .0 0004 4 0 .0 00042 0.000045 0.000036 0.000050 0.000040 0.000 1 46 0 .0 00041 0.000056 0.000036 0.000030 0.000034 0.000041 0.000046 0.000042 0. 000113 0.00004 4 0.000063 0.000053 0
. 000038 0.000032 0.000044 0 .0 00043 0.000044

Page 14 of14 Percent of Rfd0 .1 % 0. 1 % 0.1% 0
. 1% 0.1% 0. 1 % 0
. 3% 0 .1 % 0.1% 0
. 1% 0.1% 0 .1 % 0 .1 % 0 .1 % 0
. 1% 0.2% 0
. 1% 0. 1 % 0 .1 % 0.1% 0 .1% 0 .1 % 0 .1 % 0 .1 %