Docket Number: EPA

- HQ

- OPP

- 2010

- 0939

www.regulations.gov



## Formetanate HCl Summary Document Registration Review : Initial Docket

December 20 103 

### TABLE OF CONTENTS

Page

I. Preliminary Work Plan (PWP) 4

II. Fact Sheet 1 1

________________________________________________

Please Note

This Preliminary Work Plan and Fact Sheet summarize the Environmental Protection Agency's current position based on the following documents:

1. Environmental Fate and Ecological Risk Asses sment Problem Formulation In Support of Registration Review of Formetanate HCl (DP Barcode: D 372144

, December 07, 2010 )

.

2. Formetanate Hydrochloride: Registration Review Scoping Document for Human Health

Assessments (DP Barcode: D 372143

, December 09, 20 10 )

.

3. Updated Review of Formetanate HCl Incidents Reports (D P Barcode: D372150, November 24, 2009)

4

. Appendix A : Food/Feed & Non

- Food/Non

- Feed Uses Considered in Registration Review Work Planning

- Formetanate HCl (097301) ( April 07, 2009 )

.

These and other supporting documents for the formetanate hydrochloride (HCI) registration review case may be found in the docket EPA

- HQ

- OPP

- 2010

- 0 939 at www.regulations.gov.4



### I. Preliminary Work Plan

Introduction: The Food Quality Protection Act of 1996 (FQPA) ma ndated a registration review program

. All pesticides distributed or sold in the United States (U.S.) generally must be registered by the Environmental Protection Agency (EPA or the Agency), based on scientific data showing that they will not cause unreaso nable risks to human health or the environment when used as directed on product labeling. The registration review program is intended to make sure that, as the ability to assess risk evolves and as policies and practices change, all registered pesticides c ontinue to meet the statutory standard of no unreasonable adverse effects to human health or the environment. Changes in science, public policy, and pesticide use practices will occur over time. Through the registration review program, the Agency periodica lly reevaluates pesticides to make sure that as change occurs, products in the marketplace can be used safely

. Information on this program is provided at: http://www.epa.gov/oppsrrd1/registration_review/.

The Agency is implementing the r egistration r evi ew program pursuant to Section 3(g) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) , and will review each registered pesticide every 15 years to determine whether it continues to meet the FIFRA standard for registration. The Agency will consider benefits information and data as required by FIFRA. The public phase of registration review begins when the initial docket is opened for each case. The docket is the Agency’s opportunity to state what it knows about the pesticide and what addition al risk analyses and data or information it believes are needed to make a registration review

decision. After reviewing and responding to comments and data received in the docket during this initial comment period, the Agency will develop and commit to a final work plan and schedule for the registration review of formetanate hydro chloride (HCl)

.

Formetanate HCl is a n N

- methyl carbamate miticide/insecticide registered use on apple, grapefruit, lemon, lime, nectarine, orange, peach, pear, tangelo , tangeri ne, alfalfa grown for seed

, and non agricultural uncultivated areas/soils

. Formetanate HCl is not registered for use in residential or public recreational areas. T he re is one technical registration and one active end

use product registration containing fo rmetanate HCl

.

As a member of the N

- methyl carbamate (NMC) class of chemicals formetanate HCl share s a common mechanism of toxicity known to inhibit acetyl cholinesterase . The Formetanate Interim Reregistration Eligibility Decision (IRED ) was complete d in March 2006 . Based upon public

comment s received in response to the IRED, the Agency revised elements of its occupational

assessment

, and revised the Formetanate HCl IRED in April 2007. In September 2007, the Agency completed the NMC cumulative risk assessment and finalized the F ormetanate HCl

R eregistration E ligibility D ecision (RED)

.

T he technical registrant submitted a new comparative cholinesterase assay (CCA) study in August of 20 10 ( a study is designed to examine the effect s betwee n sexes as well as between

ages ) prompting a new dietary risk assessment which was completed on December 7

, 2010. The new dietary risk assessment identified risks of concern for some existing uses of formetanate

HCl . EPA is currently working with the registrant t o mitigate these concerns.5

Anticipated Risk Assessment and Data Needs: The Agency anticipates the need to require data and conduct an ecological risk assessment for formetanate HCl, including an endangered species assessment. For human health, revised dietary and occupational risk assessments may be needed during registration review to incorporate updated toxicological endpoints, exposure estimates, and data may need to be required through a registration review data call

- in. Below is a summary of the issues relevant to the registration review of formetanate HCl.

Ecological Risk :

The most recent comprehensive ecological risk assessment ( Public Docket: EPA

HQ

- OPP

- 2004

- 0032

- 0015 ) was completed in October of 2003 to support the formetanate HCl Reregistrat ion Eligibility Decision (RED).

An updated ecological risk assessment of all registered uses of formetanate HCl will be conducted during registration review. The new assessment will incorporate up

- to

- date modeling methodologies, updated toxicological en dpoints, and data submitted under the anticipated registration review data call

- in.

The Agency anticipates needing the following data in order to conduct an endangered species, non

- target ecological risk assessment for formetanate HCl

.

Environmental F ate:

o GLN 835. 213 Hydrolysis Study

o GLN 835.4100 Aerobic Soil Metabolism

o GLN 835.4200 Anaerobic Aquatic Study

o GLN 835.6100 Ter restrial Field Dissipation Stud y (with Environmental Chemistry Methods and Independent Laboratory Validation

– soil )

o GLN 835.6

2 00 Aquatic Sediment Field Dissipation (with

(Footnote 7) Environmental Chemistry Methods and Independent

Laboratory Validation

– water )

Ecological Effects:

o GLN 850.2100 Avian Acute Oral Toxicity Test (passerine species)

o GLN 850.1350 Aquatic Invert ebrate Life Cycle Toxicity (mysid shrimp)

o GLN 850.4400 Aquatic Vascular Plant Toxicity

, Tier II (Lemma sp.)

o GLN 850.5400 A lgal Toxicity, Tier II (algae)

o GLN 850.4100 Terrestrial Plant Toxicity, Tier II (Seedling Emergence)

o GLN 850.4150 Terrestrial P lant Toxicity, Tier II (Vegetative Vigor)

The Agency has not conducted a risk assessment that supports a complete endangered species determination for formetanate HCl

. The ecological risk assessment planned during registration review will allow the Agenc y to determine whether the use of

formetanate has “no effect” or “may affect” federally listed threatened or endangered6

species (listed species) or their designated critical habitats. When an assessment concludes that a pesticide’s use “may affect” a list ed species or its designated critical habitat, the Agency will consult with the U.S. Fish and Wildlife Service (FWS) and/or the National Marine Fisheries Service (NMFS) (the services) , as appropriate.

Please refer to the December 7, 2010 document: Environ mental Fate and Ecological Risk Assessment Problem Formulation In Support of Registration Review of Formetanate

HCl

, for a more detailed discussion of the anticipated ecological risk assessment and data

needs

, available in the docket

.

Human Health Risk : The most recent assessment of formetanate HCl, dietary (food + drinking water) only, was completed on December 7, 2010. Previously, t he most recent comprehensive human

health risk assessment (which included occupational risks) was conducted in December

of 2005 to support the 2006 Interim Reregistration Eligibility Decision.

The Agency may conduct a revised drinking water assessment to incorporate environmental fate data being required during the registr ation review of formetenate HCl.

A n updated forme tanate HCl acute dietary risk assessment may be required during registration review to incorporate any additional toxicity data, policy changes

, or changes

to the registered use s of formetenate HCl.

The Agency anticipates requirin g the following study , i n accordance with the revised 40 CFR, Part 158, to conduct a comprehensive human health risk assessment for the registration review of formetanate HCl.

o (GLN 870.7800) Immunotoxicity

The Agency’s residue chemistry database for formetanate HCl will be co mplete upon submission of acceptable residue chemistry data as required by the 2008 RED generic

data call

- in (see “Data Call

- In Status” section for more information).

There are no residential uses associated with formetanate HCl registrations; therefore

, the anticipated aggregate risk assessment will include only dietary exposure (food + drinking water).

Formetanate HCl shares a common mode of action with other NMCs. Prior to a final registration review decision for formetanate HCl, the Agency will deter mine if there is any new information, such as new hazard or exposure data or information on changes to the use pattern, which would affect the cumulative risk assessment. Should the Agency

determine that new information on formetanate HCl is available tha t could potentially impact the cumulative risk assessment and result in a risk of concern, the Agency will

revisit the cumulative risk assessment.7

The tolerance expression in 40 CFR § 180.276 will be revised during registration review to ensure that it ap propriately covers the metabolites and degrades of formetanate HCl

, and that it specifies the residues to be measured for each commodity.

T he Agency anticipate s conducting an occupational handler and post

- application r isk assessment during the r e gistrat ion r eview of formetanate HCl to incorporate new toxicological endpoints and any revisions to current guidelines and assessment methodologies

.

Please refer to the December 9, 2010 document: Formetanate Hydrochloride (HCl): Registration Review Scoping Doc ument for Human Health Assessments

, for a more detailed discussion of the anticipated human health risk assessment and data needs,

available in the docket.

Other Data Needs: GLDN 830.7050 UV/Visible Light Absorption

– this study is a new data requirement under 40 CFR part 158 (Product Chemistry Data Requirements) for registration of a pesticide (food and non

- food uses). The Agency anticipates requiring this study to obtain basic information about the compound’s identity/composition and the wavelengths at which the compound may be susceptible to photochemical degradation.

Endocrine Disruptor Screening Program:

For all pesticides that result in residues in foods, EPA review s numerous studies that bear on a pesticide's potential endocrine effects. (71 FR at 43921). These include data on developmental toxicity, reproductive toxicity, subchronic toxicity, chronic toxicity, and cancer. Developmental studies evaluate several endp oints susceptible to endocrine influence including effects on maternal animal fertility and pregnancy rates and on pup viability and sex ratios in pups. (71 FR at 43921). As part of the 2007 IRED, EPA reviewed these data and concluded that the most

appropr iate and conservative regulatory endpoint was based on acetylcholinesterase inhibition

. However, as required by FFDCA section 408(p), formetanate HCl will be subject to endocrine screening as part of the Endocrine Disruptor Screening Program (EDSP)

As required under FFDCA section 408(p), EPA has developed the EDSP to determine whether certain substances (including pesticide active and other ingredients) may have an effect in humans or wildlife similar to an effect produced by a “naturally occurring estr ogen, or other such endocrine effects as the Administrator may designate.” The EDSP employs a two

- tiered approach to making the statutorily required determinations. Tier 1 consists of a battery of 11 screening assays to identify the potential of a chemic al substance to interact with the estrogen, androgen, or thyroid (E, A, or T) hormonal systems. Chemicals that go through Tier 1 screening and are found to have the potential to interact with E, A, or T hormonal systems will proceed to the next stage of t he EDSP where EPA will determine which, if any, of the Tier 2 tests are necessary based on the available data. Tier 2 testing is designed to identify any adverse endocrine related effects caused by the substance, and establish a dose

- response relationship between the dose and the E, A, or T effect.8

EPA has announced that it would begin to expedite the required EDSP testing of pesticides by conducting the testing in parallel or as part of the OPP Registration Review program. Recently, EPA published a list of candidate chemicals based, in part, on pesticides that were scheduled for Registration Review during fiscal years 2007 and 2008. Formetanate HCl was not on that list. But as part of the Registration Review of formetanate HCl, EPA will iss ue an EDSP t est
order/data call

- in to require that testing. Once all required Tier 1 and Tier 2 data have been received and reviewed, the points of departure and safety factors used for risk assessment purposes should be reexamined and a new risk assessment performed if necessary.

Timeline: EPA has created the following estimated timeline for the completion of the registration review of

formetanate HCl

.

Registration Review for Formetanate HCl

– Projected Registration Review Timeline

Activities Estimated Date
Op ening the docket
Open Public Comment Period for the Formetanate HCl Docket 2010

– December

Close Public Comment Period 201 1

– February
Case Development

Develop Final Work Plan (FWP) 201 1

– May

Issue DCI 201 2

– Jan.

– Mar.

Data S ubmission 201 4

– Jan.

– Mar.
Open Public Comment Period for Preliminary Risk Assessments 201 5

– Jul.

– Sept.

Close Public Comment Period 2015

– Oct.

– Dec.

Registration Review Decision
Open Public Comment Period for Proposed Reg. Review D ecision 201 6

– Jan.

– Mar.

Close Public C omment P eriod 2016

– Apr.

– June

Final D ecision and Begin P ost

- D ecision F ollow

- up 201 6
Total ( years ) 6 1

1 An assessment of the potential cumulative risk from the NMC class of insecticides may impact this time estimate.

Gui dance for Commenters : The public is invited to comment on EPA’s preliminary registration review work plan and rationale. The Agency will carefully consider all comments as well as any additional information or data provided in a timely manner prior to iss uing a final work plan for the

formetanate HCl case.

Trade Irritants Through the registration review process, the Agency intends to solicit information on trade irritants and, to the extent feasible, take steps toward facilitating irritant resolution. Gr owers and other stakeholders are asked to comment on any trade irritant issues resulting from lack of9

Maximum Residue Limits (MRLs) or disparities between U.S. tolerances and MRLs in key export markets, providing as much specificity as possible regarding t he nature of the concern.

Water Quality

Formetanate HCl is not identified as a cause of impairment for any water bodies listed as impaired under section 303(d) of the Clean Water Act, based on information provided at http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_group_id=88

5 . In addition, no Total Maximum Daily Loads (TMDL) have been developed for formetanate

HCl , based on information provided at http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_deta il?p_pollutant_group_id =885&p_pollutant_group_name=PESTICIDES . More information on impaired water bodies and

TMDLs can be found at http://www.epa.gov/owow/tmdl/ . The Agency invites submission of

water qua lity data for this pesticide. To the extent possible, data should conform to the quality standards in Appendix A of the OPP Standard Operating Procedure: Inclusion of Impaired Water Body and Other Water Quality Data in OPP’s Registration Review Risk Asses sment and Management Process (see: http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm ) in order to ensure they can be used quantitatively or qualitati vely in pesticide risk assessments.

Environmental Justice EPA seeks to achieve environmental justice, the fair treatment and meaningful involvement of all people, regardless of race, color, national origin, or income, in the development, implementation,

a nd enforcement of environmental laws, regulations, and policies. To help address potential environmental justice issues, the Agency seeks information on m any groups or segments of the population who, as a result of their location, cultural practices, or o ther factors, may have atypical, unusually high exposure to formetanate HCl , c ompared to the general population. Please comment if you are aware of any sub

- populations that may have atypical, unusually high exposure compared to the general population.

Oth er Information Stakeholders are also specifically asked to provide information and data that will assist the Agency in refining the risk assessment s , including any species

- specific ecological effects

determinations.

The Agency is interested in receiving the following information:

1. confirmation on the following label information

a. frequency of application, application intervals, and maximum number of applications per season

b. geographic limitations on use

2. use or potential use distribution (e.g., acreage and geographical distribution of relevant crops)

3. use history10

4. median and 90 th percentile reported use rates (lbs. a.i./acre) from usage data

– national, state, and county

5. application timing (date of first application and application intervals) by crop

– nationa l, state, and county

6. sub

- county crop location data

7. usage/use information for non

- agricultural uses (e.g., forestry, rights

- of

- way)

8. directly acquired county

- level usage data (not derived from state level data)

a. maximum reported use rate (lbs. a.i./acre) from usage data

– county
b. percent crop treated

– county

c. median and 90 th percentile number of applications

– county
d. total pounds per year

– county

e. the year the pesticide was last used in the county/sub

- county area
f. the years in which the pesticide was applied in the county/sub

- county area
9. typical interval (days) between applications

10. state or local use restrictions

11. ecological incidents (non

- target plant damage and avian, fish, reptilian, amphibian and mammalian mortalities) not already reported to the Agency

12. monito ring data

Next Steps:

After the 60

- day comment period closes, the Agency will review and respond to any comments
received in a timely manner

, and then issue a Final Work Plan for the formetanate HCl registration review case

.11

II. FACT SHEET

Background Information :
The formetanate HCl PC Code is 097301 and the CAS# is 23422

- 53

- 9

. The formetanate HCl registration review case number is 0091.

The t echnical registrant is Gowan Company

. Formetanate HCl was f

irst registered on December 30, 1963. T he IRED w as completed

in March 2006 , revised in April 2007, and the RED was finalized in September 2007 ( upon completion of the Revised N

- Methyl Carbamate Cumulative Risk Assessment )

. There are two active section 3 product registrations for formetanate HCl : one tec hnical product and one end

- use product

. Product labels were amended in November 2007 to incorporate labeling requirements

from the formetanate HCl RED.

The Chemical Review Manager (CRM) : James Parker: parker.jam es@epa.gov

. The P roduct Manager (PM): Venus Eagle : eagle.venus@epa.gov

.

Use & Usage Information:

Formetanate HCl is an insecticide registered for use on apple, grapefruit, lemon, lime, nectarine, orange, peac h, pear tangelo tangerine, alfalfa grown for seed and uncultivated

areas to control various insect pests such as thirps, stink bugs, spider mites, campylloma, pear rust mites and lygus bugs

. Formetanate HCl is formulated as a wettable powder and is applied v ia ground equipment; aerial equipment is allowed for only certain uses ( sometimes alfalfa grown for seed)

. Depending on the specific use and application method, single maximum application rates

of formetanate HCl range from 0.5 to 1.25 pounds of active ingredient per acre. Formetanate HCl is not registered for use in residential areas.

Recent Actions:

There is a pending action to establish a new section 3 formetanate HCl use on onions

. A Section 18 tolerance for formetanate HCl use on onion, dry bulb, was withdrawn in

December 2009.

Ecological Risk Assessment Status : Please refer to the December 7, 2010 document: Environmental Fate and Ecological Risk Assessment Problem Formulation In Support of Registration Review of Formetanate HCl in the registrat ion review docket for a detailed summary of the key findings of the most recent

environmental fate and effects assessment

. A summary follows

.

Risks to Mammals :
E stimated risks for acute exposure to mamma ls exceeded levels of concern (LOC)

, risk quotient s ( RQs ) ranged from 0.14 to 17.72

. Similarly, chronic exposure to mammals also

exceeded the LOC with RQ’s ranging from 1.38 to 27.6

.12

Risks to Birds: Most estimated risks to birds from acute exposure were not of concern to the Agency. (R isks to listed s pecies from acute exposure [consuming short grass] was of concern

, RQ = 0.2, for the maximum application rate, 1.15 lb a

. i/A

. ) Risk from c hronic exposure to
avian species exceeded the Agency’s LOC with RQs ranging from 0.26 to 5.2

.

Risks to Aquatic Orga nisms :
Acute risk to freshwater fish, freshwater invertebrates, and estuarine/marine invertebrates were below the Agency’s LOC for all uses. Chronic risk to freshwater fish is also below the Agency’s LOC. However, the chronic risk to fre shwater inverteb rate s was above the Agency’s LOC with an RQ value of 1.1 2.

Risks to Non

- Target Plants :
There were no indica tions of phytotoxicity from the use of formetanate HCl on plants; therefore, a risk assessment for plants was not previously condu cted.

Beneficia l Insects :
Formetanate HCl was found to be practically non

- toxic to beneficial insects (e.g., bees)

on an acute contact basis

. However, the 2003 Ecological risk assessment did identify

hazard in the field and concluded that bee hazard label l anguage was n eeded.

Human Health Risk Assessment Status:

Please refer to the December 9, 2010 document: Formetanate Hydrochloride (HCL): Registration Review Scoping Document for Human Health Assessments in the registration review

docket for a detailed summary of th e key findings of the most recent human health assessment

. A summary follows:

Ha z ard Characterization :
Like other member s of the N

- methyl carbamate class

, f ormetanate HCl ’s mode of action

is inhibition of the acetyl cholinesterase enzyme (AChE)

.

The Age ncy recently updated its endpoint analysis for formetanate HCl to incorporate recently received (comparative cholinesterase) data. (The Formetanate Hydrochloride:

HED Human Health Risk Assessment (12/07/2010) can be found in the formetenate HCl registrati on review docket).

Formetanate HCl is categorized as Toxicity Category I via the acute oral route, moderate toxicity via the inhalation route

, and is not an eye irritant. It is also a dermal sensitizer, but exhibits low toxicity via the dermal route.

Fo rmetanate HCl is classified as a group “E” carcinogen (no evidence of carcinogenicity) per there is no evidence of carcinogenic effect in rats or mice.13

Dietary Risks (Food and Drinking Water ):

The December 7, 2010, revi sed acute dietary (food plus dr inking water) risk identified

risks above the Agency’s LOC

, at the 99.9 th percentile of exposure

, for a ll i nfants (<1year old) at 300% of the acute population adjusted dose ( aPAD ) and c hildren 1

- 2 year s old at
150 % of the aPAD. The Agency is currently wor king with the registrant to mitigate these

concerns.

Due to the rapid recovery of cholinesterase activity after exposure to formetanate HCl, a chronic dietary assessment was not conducted as part of the recent ly revised dietary risk

assessment.

Residen tial:

Formetanate HCl registrations do not include residential uses, t herefore, a residential

assessment was not conducted.

Aggregate: Since there are no residential exposures from the use of formetenate HCl, t he aggregate risk estimates were equivalent t o the acute dietary (food and drinking water) risk

estimates

.

Occupational: The most recent occupational risk assessment was conducted in 2005 to support the 200 6 formetanate HCl IRED (and 2007 formetanate HCl RED). The I RED required mitigation

measures to reduce occupation al risks below the Agency ’s LOC ( such as, additional protective label language, personal protective equipment (PPE)

, engineering controls, extended restricted entry intervals (REIs)

, and prohibit ing certain applications).

Cumulative : The Food Quality Protection Act (FQPA) requires the Agency to consider the cumulative risks of chemicals sharing a common mechanism of toxicity. Formetanate HCl is a

member of the N

- methyl carbamate common mechanism group. The most recent

cumulative ris k assessment for the NMC carbamates was issued on September 26, 2007

and is available at http://www.epa.gov/oppsrrd1/REDs/nmc_revised_cra.pdf

.

Use of Studies with Human Subjects :
Past f ormetanate HCl risk assessments rel ied in part on data from studies in which adult human subjects were intentionally exposed to a pesticide to determine their dermal and inhalation exposure. Many such studies, involving exposure to many different pesticid es, comprise generic pesticide exposure databases such as the Pesticide Ha ndlers Exposure Database (PHED) and the Agricultural Reentry Task Force (ARTF) Database

. EPA has reviewed all the studies supporting these multi

- pesticide generic exposure databases , and has found no clear and convincing evidence that the conduct of any of them was either fundamentally unethical or significantly deficient relative to the ethical standards prevailing at the time the research was conducted. A ll applicable requirements of EPA’s Rule for the Protection of Human Subjects of Research (40 CFR Part 26) have been

satisfied , and t here is no regulatory barrier to continued reliance on these studies

.14

Incident Reports :
The Agency’s evaluation of the OPP I ncident D ata S ystem (I DS) did not identify any

human health incidents in the United States from 2002 to the present for formetenate

HCl.

The Centers for Disease Control and Prevention/National Institute for Occupatio nal Safety and Health Sentinel Event Notification System for Occupational Risk (CDC/ NIOSH SENSOR ) database identified three occupational cases where

- in workers ( one mixer/loader and two applicators ) were exposed to formetanate HCl. In all cases, the individuals indicated dermal, gastroint estinal and neurological s ymptoms . These exposures were categorized as low to moderate severity.

The Ecological Incident Information System (EIIS, version 2.1), which is maintained by the Agency’s Office of Pesticide Programs, and the Avian Monitoring Information System (AIMS), which is maintained by the American Bird Conservancy, indicated no reported ecological incidents associated with the use of f ormetanate HCl.

Tolerances and International Harmonization :
Tolerances are established in 40 CFR § 180.276 for residu es of forme tanate HCl in or on apple; pear; peach; nectarine; orange; lemon; lime; g rapefruit; tangelo and tangerine.

Canada ha s established maximum residue limits (MRLs) for formetanate HCl but they

are not harmonized with all US tolerances. The Codex Alimentari us Commission has not currently established MRLs for formetanate HCl. The Agency will work to harmonize tolerances/MRLs, where possible, during registration review

.

Data Call

- In Status: In June of 2008, the Formetanate HCl RED generic data call

- in (GDCI ) was issued. Data required through this DCI remain outstanding, and include the following studies

.

Toxicology :

o 870.3465 (90

- day) Inhalation Study

Residue Chemistry :

o 860.1300 Nature of the Residue

- storage stability of peach leaves ( t o support th e storage stability of peach extract )

o 860.1500 Crop Field Trials: Apple (4 trials), Pear (2 trials), Peach (2 trials), Nectarine (confirmatory data), Citrus (5 orange trials, 1 lemon trial, and 2 grapefruit trials)15

Labels :
Formetanate HCl labels can be obtained from the Pesticide Product Label Sy s tem (PPLS)

website: http://oaspub.epa.gov/pestlabl/ppls.home

. A summary of formetanate HCl labels is provided in the table below.



### Formetanate Hydroc hloride Products
Registration

Number Product Name Active Ingredient

10163

- 264 Formetanate Hydrochloride Technical 92 %

10163

- 265 Carzol SP Miticide/Insecticide in Water Soluble Packaging 92 %