Docket Number: EPA-HQ-OPP-2010-0939

www.regulations.gov

Formetanate HCl Summary Document

Registration Review: Initial Docket

December 2010

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TABLE OF CONTENTS

Page 

I. Preliminary Work Plan (PWP) 4

II. Fact Sheet 11

________________________________________________

Please Note

This Preliminary Work Plan and Fact Sheet summarize the Environmental Protection Agency's 

current position based on the following documents: 

1. Environmental Fate and Ecological Risk Assessment Problem Formulation In Support of 

Registration Review of Formetanate HCl (DP Barcode: D372144, December 07, 2010).

2. Formetanate Hydrochloride: Registration Review Scoping Document for Human Health 

Assessments (DP Barcode: D372143, December 09, 2010).

3. Updated Review of Formetanate HCl Incidents Reports (DP Barcode: D372150, 

November 24, 2009)

4. Appendix A: Food/Feed & Non-Food/Non-Feed Uses Considered in Registration Review 

Work Planning - Formetanate HCl (097301) (April 07, 2009).

These and other supporting documents for the formetanate hydrochloride (HCI) registration 

review case may be found in the docket EPA-HQ-OPP-2010-0939 at www.regulations.gov.
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I. Preliminary Work Plan

Introduction:

The Food Quality Protection Act of 1996 (FQPA) mandated a registration review program. All 

pesticides distributed or sold in the United States (U.S.) generally must be registered by the 

Environmental Protection Agency (EPA or the Agency), based on scientific data showing that 

they will not cause unreasonable risks to human health or the environment when used as directed 

on product labeling. The registration review program is intended to make sure that, as the ability 

to assess risk evolves and as policies and practices change, all registered pesticides continue to 

meet the statutory standard of no unreasonable adverse effects to human health or the 

environment. Changes in science, public policy, and pesticide use practices will occur over time. 

Through the registration review program, the Agency periodically reevaluates pesticides to make 

sure that as change occurs, products in the marketplace can be used safely. Information on this 

program is provided at: http://www.epa.gov/oppsrrd1/registration_review/. 

The Agency is implementing the registration review program pursuant to Section 3(g) of the 

Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), and will review each registered 

pesticide every 15 years to determine whether it continues to meet the FIFRA standard for 

registration. The Agency will consider benefits information and data as required by FIFRA. The 

public phase of registration review begins when the initial docket is opened for each case. The 

docket is the Agency’s opportunity to state what it knows about the pesticide and what additional 

risk analyses and data or information it believes are needed to make a registration review 

decision. After reviewing and responding to comments and data received in the docket during 

this initial comment period, the Agency will develop and commit to a final work plan and 

schedule for the registration review of formetanate hydrochloride (HCl). 

Formetanate HCl is an N-methyl carbamate miticide/insecticide registered use on apple, 

grapefruit, lemon, lime, nectarine, orange, peach, pear, tangelo, tangerine, alfalfa grown for seed,

and nonagricultural uncultivated areas/soils. Formetanate HCl is not registered for use in 

residential or public recreational areas. There is one technical registration and one active enduse product registration containing formetanate HCl. 

As a member of the N-methyl carbamate (NMC) class of chemicals formetanate HCl shares a 

common mechanism of toxicity known to inhibit acetyl cholinesterase. The Formetanate Interim 

Reregistration Eligibility Decision (IRED) was completed in March 2006. Based upon public 

comments received in response to the IRED, the Agency revised elements of its occupational 

assessment, and revised the Formetanate HCl IRED in April 2007. In September 2007, the 

Agency completed the NMC cumulative risk assessment and finalized the Formetanate HCl 

Reregistration Eligibility Decision (RED). 

The technical registrant submitted a new comparative cholinesterase assay (CCA) study in

August of 2010 (a study is designed to examine the effects between sexes as well as between 

ages) prompting a new dietary risk assessment which was completed on December 7, 2010. The 

new dietary risk assessment identified risks of concern for some existing uses of formetanate 

HCl. EPA is currently working with the registrant to mitigate these concerns.
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Anticipated Risk Assessment and Data Needs:

The Agency anticipates the need to require data and conduct an ecological risk assessment for 

formetanate HCl, including an endangered species assessment. For human health, revised

dietary and occupational risk assessments may be needed during registration review to 

incorporate updated toxicological endpoints, exposure estimates, and data may need to be 

required through a registration review data call-in. Below is a summary of the issues relevant to 

the registration review of formetanate HCl.

Ecological Risk:

The most recent comprehensive ecological risk assessment (Public Docket: EPAHQ-OPP-2004-0032-0015) was completed in October of 2003 to support the 

formetanate HCl Reregistration Eligibility Decision (RED).

An updated ecological risk assessment of all registered uses of formetanate HCl 

will be conducted during registration review. The new assessment will 

incorporate up-to-date modeling methodologies, updated toxicological endpoints, 

and data submitted under the anticipated registration review data call-in. 

The Agency anticipates needing the following data in order to conduct an 

endangered species, non-target ecological risk assessment for formetanate HCl. 

Environmental Fate:

o GLN 835.213 Hydrolysis Study

o GLN 835.4100 Aerobic Soil Metabolism

o GLN 835.4200 Anaerobic Aquatic Study

o GLN 835.6100 Terrestrial Field Dissipation Study (with

Environmental Chemistry Methods and Independent 

Laboratory Validation – soil)

o GLN 835.6200 Aquatic Sediment Field Dissipation (with 

(Footnote 7) Environmental Chemistry Methods and Independent 

Laboratory Validation – water)

Ecological Effects:

o GLN 850.2100 Avian Acute Oral Toxicity Test (passerine species)

o GLN 850.1350 Aquatic Invertebrate Life Cycle Toxicity (mysid 

shrimp)

o GLN 850.4400 Aquatic Vascular Plant Toxicity, Tier II (Lemma 

sp.)

o GLN 850.5400 Algal Toxicity, Tier II (algae)

o GLN 850.4100 Terrestrial Plant Toxicity, Tier II (Seedling 

Emergence)

o GLN 850.4150 Terrestrial Plant Toxicity, Tier II (Vegetative Vigor)

The Agency has not conducted a risk assessment that supports a complete endangered 

species determination for formetanate HCl. The ecological risk assessment planned 

during registration review will allow the Agency to determine whether the use of 

formetanate has “no effect” or “may affect” federally listed threatened or endangered 
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species (listed species) or their designated critical habitats. When an assessment 

concludes that a pesticide’s use “may affect” a listed species or its designated critical 

habitat, the Agency will consult with the U.S. Fish and Wildlife Service (FWS) and/or 

the National Marine Fisheries Service (NMFS) (the services), as appropriate.

Please refer to the December 7, 2010 document: Environmental Fate and Ecological Risk 

Assessment Problem Formulation In Support of Registration Review of Formetanate 

HCl, for a more detailed discussion of the anticipated ecological risk assessment and data

needs, available in the docket.

Human Health Risk:

The most recent assessment of formetanate HCl, dietary (food + drinking water) only, 

was completed on December 7, 2010. Previously, the most recent comprehensive human 

health risk assessment (which included occupational risks) was conducted in December 

of 2005 to support the 2006 Interim Reregistration Eligibility Decision. 

The Agency may conduct a revised drinking water assessment to incorporate 

environmental fate data being required during the registration review of formetenate HCl.

An updated formetanate HCl acute dietary risk assessment may be required during 

registration review to incorporate any additional toxicity data, policy changes, or changes 

to the registered uses of formetenate HCl.

The Agency anticipates requiring the following study, in accordance with the revised 40 

CFR, Part 158, to conduct a comprehensive human health risk assessment for the 

registration review of formetanate HCl.

o (GLN 870.7800) Immunotoxicity

The Agency’s residue chemistry database for formetanate HCl will be complete upon 

submission of acceptable residue chemistry data as required by the 2008 RED generic 

data call-in (see “Data Call-In Status” section for more information).

There are no residential uses associated with formetanate HCl registrations; therefore, the 

anticipated aggregate risk assessment will include only dietary exposure (food + drinking 

water).

Formetanate HCl shares a common mode of action with other NMCs. Prior to a final 

registration review decision for formetanate HCl, the Agency will determine if there is 

any new information, such as new hazard or exposure data or information on changes to 

the use pattern, which would affect the cumulative risk assessment. Should the Agency 

determine that new information on formetanate HCl is available that could potentially 

impact the cumulative risk assessment and result in a risk of concern, the Agency will 

revisit the cumulative risk assessment.
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The tolerance expression in 40 CFR § 180.276 will be revised during registration review 

to ensure that it appropriately covers the metabolites and degrades of formetanate HCl, 

and that it specifies the residues to be measured for each commodity. 

The Agency anticipates conducting an occupational handler and post-application risk 

assessment during the registration review of formetanate HCl to incorporate new 

toxicological endpoints and any revisions to current guidelines and assessment 

methodologies.

Please refer to the December 9, 2010 document: Formetanate Hydrochloride (HCl): 

Registration Review Scoping Document for Human Health Assessments, for a more 

detailed discussion of the anticipated human health risk assessment and data needs,

available in the docket.

Other Data Needs:

GLDN 830.7050 UV/Visible Light Absorption – this study is a new data requirement 

under 40 CFR part 158 (Product Chemistry Data Requirements) for registration of a 

pesticide (food and non-food uses). The Agency anticipates requiring this study to obtain 

basic information about the compound’s identity/composition and the wavelengths at 

which the compound may be susceptible to photochemical degradation.

Endocrine Disruptor Screening Program:

For all pesticides that result in residues in foods, EPA reviews numerous studies that bear on a 

pesticide's potential endocrine effects. (71 FR at 43921). These include data on developmental 

toxicity, reproductive toxicity, subchronic toxicity, chronic toxicity, and cancer. Developmental 

studies evaluate several endpoints susceptible to endocrine influence including effects on 

maternal animal fertility and pregnancy rates and on pup viability and sex ratios in pups. (71 FR 

at 43921). As part of the 2007 IRED, EPA reviewed these data and concluded that the most 

appropriate and conservative regulatory endpoint was based on acetylcholinesterase inhibition. 

However, as required by FFDCA section 408(p), formetanate HCl will be subject to endocrine 

screening as part of the Endocrine Disruptor Screening Program (EDSP)

As required under FFDCA section 408(p), EPA has developed the EDSP to determine whether 

certain substances (including pesticide active and other ingredients) may have an effect in 

humans or wildlife similar to an effect produced by a “naturally occurring estrogen, or other such 

endocrine effects as the Administrator may designate.” The EDSP employs a two-tiered 

approach to making the statutorily required determinations. Tier 1 consists of a battery of 11 

screening assays to identify the potential of a chemical substance to interact with the estrogen, 

androgen, or thyroid (E, A, or T) hormonal systems. Chemicals that go through Tier 1 screening 

and are found to have the potential to interact with E, A, or T hormonal systems will proceed to 

the next stage of the EDSP where EPA will determine which, if any, of the Tier 2 tests are 

necessary based on the available data. Tier 2 testing is designed to identify any adverse 

endocrine related effects caused by the substance, and establish a dose-response relationship

between the dose and the E, A, or T effect.
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EPA has announced that it would begin to expedite the required EDSP testing of pesticides by 

conducting the testing in parallel or as part of the OPP Registration Review program. Recently, 

EPA published a list of candidate chemicals based, in part, on pesticides that were scheduled for 

Registration Review during fiscal years 2007 and 2008. Formetanate HCl was not on that list. 

But as part of the Registration Review of formetanate HCl, EPA will issue an EDSP test 

order/data call-in to require that testing. Once all required Tier 1 and Tier 2 data have been 

received and reviewed, the points of departure and safety factors used for risk assessment 

purposes should be reexamined and a new risk assessment performed if necessary.

Timeline:

EPA has created the following estimated timeline for the completion of the registration review of 

formetanate HCl. 

Registration Review for Formetanate HCl – Projected Registration Review Timeline

Activities Estimated Date

Opening the docket

Open Public Comment Period for the Formetanate HCl Docket 2010 – December

Close Public Comment Period 2011 – February

Case Development

Develop Final Work Plan (FWP) 2011– May

Issue DCI 2012 – Jan. – Mar. 

Data Submission 2014 – Jan. – Mar. 

Open Public Comment Period for Preliminary Risk Assessments 2015 – Jul. – Sept.

Close Public Comment Period 2015 – Oct. – Dec.

Registration Review Decision

Open Public Comment Period for Proposed Reg. Review Decision 2016 – Jan. – Mar. 

Close Public Comment Period 2016 – Apr. – June

Final Decision and Begin Post-Decision Follow-up 2016

Total (years) 61

1 An assessment of the potential cumulative risk from the NMC class of insecticides may impact this time estimate. 

Guidance for Commenters:

The public is invited to comment on EPA’s preliminary registration review work plan and 

rationale. The Agency will carefully consider all comments as well as any additional 

information or data provided in a timely manner prior to issuing a final work plan for the 

formetanate HCl case.

Trade Irritants

Through the registration review process, the Agency intends to solicit information on trade 

irritants and, to the extent feasible, take steps toward facilitating irritant resolution. Growers and 

other stakeholders are asked to comment on any trade irritant issues resulting from lack of 
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Maximum Residue Limits (MRLs) or disparities between U.S. tolerances and MRLs in key 

export markets, providing as much specificity as possible regarding the nature of the concern. 

Water Quality

Formetanate HCl is not identified as a cause of impairment for any water bodies listed as 

impaired under section 303(d) of the Clean Water Act, based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_group_id=88

5. In addition, no Total Maximum Daily Loads (TMDL) have been developed for formetanate 

HCl, based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detail?p_pollutant_group_id

=885&p_pollutant_group_name=PESTICIDES. More information on impaired water bodies and 

TMDLs can be found at http://www.epa.gov/owow/tmdl/. The Agency invites submission of 

water quality data for this pesticide. To the extent possible, data should conform to the quality 

standards in Appendix A of the OPP Standard Operating Procedure: Inclusion of Impaired 

Water Body and Other Water Quality Data in OPP’s Registration Review Risk Assessment and 

Management Process (see: 

http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm) in order to ensure they 

can be used quantitatively or qualitatively in pesticide risk assessments.

Environmental Justice

EPA seeks to achieve environmental justice, the fair treatment and meaningful involvement of all 

people, regardless of race, color, national origin, or income, in the development, implementation, 

and enforcement of environmental laws, regulations, and policies. To help address potential 

environmental justice issues, the Agency seeks information on many groups or segments of the 

population who, as a result of their location, cultural practices, or other factors, may have 

atypical, unusually high exposure to formetanate HCl, compared to the general population. 

Please comment if you are aware of any sub-populations that may have atypical, unusually high 

exposure compared to the general population.

Other Information

Stakeholders are also specifically asked to provide information and data that will assist the 

Agency in refining the risk assessments, including any species-specific ecological effects 

determinations. 

The Agency is interested in receiving the following information: 

1. confirmation on the following label information

a. frequency of application, application intervals, and maximum number of 

applications per season

b. geographic limitations on use

2. use or potential use distribution (e.g., acreage and geographical distribution of relevant 

crops)

3. use history
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4. median and 90th percentile reported use rates (lbs. a.i./acre) from usage data – national, 

state, and county

5. application timing (date of first application and application intervals) by crop – national, 

state, and county

6. sub-county crop location data

7. usage/use information for non-agricultural uses (e.g., forestry, rights-of-way)

8. directly acquired county-level usage data (not derived from state level data)

a. maximum reported use rate (lbs. a.i./acre) from usage data – county

b. percent crop treated – county

c. median and 90th percentile number of applications – county

d. total pounds per year – county

e. the year the pesticide was last used in the county/sub-county area

f. the years in which the pesticide was applied in the county/sub-county area

9. typical interval (days) between applications

10. state or local use restrictions

11. ecological incidents (non-target plant damage and avian, fish, reptilian, amphibian and 

mammalian mortalities) not already reported to the Agency

12. monitoring data 

Next Steps:

After the 60-day comment period closes, the Agency will review and respond to any comments 

received in a timely manner, and then issue a Final Work Plan for the formetanate HCl

registration review case.
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II. FACT SHEET

Background Information:

The formetanate HCl PC Code is 097301 and the CAS# is 23422-53-9.

The formetanate HCl registration review case number is 0091.

The technical registrant is Gowan Company.

Formetanate HCl was first registered on December 30, 1963. The IRED was completed 

in March 2006, revised in April 2007, and the RED was finalized in September 2007 

(upon completion of the Revised N-Methyl Carbamate Cumulative Risk Assessment).

There are two active section 3 product registrations for formetanate HCl: one technical

product and one end-use product.

Product labels were amended in November 2007 to incorporate labeling requirements 

from the formetanate HCl RED.

The Chemical Review Manager (CRM): James Parker: parker.james@epa.gov.

The Product Manager (PM): Venus Eagle: eagle.venus@epa.gov. 

Use & Usage Information: 

Formetanate HCl is an insecticide registered for use on apple, grapefruit, lemon, lime, 

nectarine, orange, peach, pear tangelo tangerine, alfalfa grown for seed and uncultivated 

areas to control various insect pests such as thirps, stink bugs, spider mites, campylloma, 

pear rust mites and lygus bugs.

Formetanate HCl is formulated as a wettable powder and is applied via ground 

equipment; aerial equipment is allowed for only certain uses (sometimes alfalfa grown 

for seed). 

Depending on the specific use and application method, single maximum application rates 

of formetanate HCl range from 0.5 to 1.25 pounds of active ingredient per acre. 

Formetanate HCl is not registered for use in residential areas.

Recent Actions:

There is a pending action to establish a new section 3 formetanate HCl use on onions.

A Section 18 tolerance for formetanate HCl use on onion, dry bulb, was withdrawn in 

December 2009.

Ecological Risk Assessment Status:

Please refer to the December 7, 2010 document: Environmental Fate and Ecological Risk 

Assessment Problem Formulation In Support of Registration Review of Formetanate HCl in the 

registration review docket for a detailed summary of the key findings of the most recent 

environmental fate and effects assessment. A summary follows.

Risks to Mammals:

Estimated risks for acute exposure to mammals exceeded levels of concern (LOC), risk 

quotients (RQs) ranged from 0.14 to 17.72. Similarly, chronic exposure to mammals also 

exceeded the LOC with RQ’s ranging from 1.38 to 27.6.
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Risks to Birds:

Most estimated risks to birds from acute exposure were not of concern to the Agency. 

(Risks to listed species from acute exposure [consuming short grass] was of concern, RQ 

= 0.2, for the maximum application rate, 1.15 lb a.i/A.) Risk from chronic exposure to

avian species exceeded the Agency’s LOC with RQs ranging from 0.26 to 5.2. 

Risks to Aquatic Organisms:

Acute risk to freshwater fish, freshwater invertebrates, and estuarine/marine invertebrates 

were below the Agency’s LOC for all uses. Chronic risk to freshwater fish is also below 

the Agency’s LOC. However, the chronic risk to freshwater invertebrates was above the 

Agency’s LOC with an RQ value of 1.12.

Risks to Non-Target Plants:

There were no indications of phytotoxicity from the use of formetanate HCl on plants; 

therefore, a risk assessment for plants was not previously conducted.

Beneficial Insects:

Formetanate HCl was found to be practically non-toxic to beneficial insects (e.g., bees)

on an acute contact basis. However, the 2003 Ecological risk assessment did identify 

hazard in the field and concluded that bee hazard label language was needed.

Human Health Risk Assessment Status:

Please refer to the December 9, 2010 document: Formetanate Hydrochloride (HCL): 

Registration Review Scoping Document for Human Health Assessments in the registration review 

docket for a detailed summary of the key findings of the most recent human health assessment. 

A summary follows:

Hazard Characterization:

Like other members of the N-methyl carbamate class, formetanate HCl’s mode of action

is inhibition of the acetyl cholinesterase enzyme (AChE).

The Agency recently updated its endpoint analysis for formetanate HCl to incorporate 

recently received (comparative cholinesterase) data. (The Formetanate Hydrochloride: 

HED Human Health Risk Assessment (12/07/2010) can be found in the formetenate HCl 

registration review docket).

Formetanate HCl is categorized as Toxicity Category I via the acute oral route, moderate 

toxicity via the inhalation route, and is not an eye irritant. It is also a dermal sensitizer, 

but exhibits low toxicity via the dermal route.

Formetanate HCl is classified as a group “E” carcinogen (no evidence of carcinogenicity) 

per there is no evidence of carcinogenic effect in rats or mice.
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Dietary Risks (Food and Drinking Water):

The December 7, 2010, revised acute dietary (food plus drinking water) risk identified

risks above the Agency’s LOC, at the 99.9th percentile of exposure, for all infants (<1year 

old) at 300% of the acute population adjusted dose (aPAD) and children 1-2 years old at 

150% of the aPAD. The Agency is currently working with the registrant to mitigate these 

concerns. 

Due to the rapid recovery of cholinesterase activity after exposure to formetanate HCl, a 

chronic dietary assessment was not conducted as part of the recently revised dietary risk 

assessment. 

Residential:

Formetanate HCl registrations do not include residential uses, therefore, a residential 

assessment was not conducted.

Aggregate:

Since there are no residential exposures from the use of formetenate HCl, the aggregate 

risk estimates were equivalent to the acute dietary (food and drinking water) risk 

estimates. 

Occupational:

The most recent occupational risk assessment was conducted in 2005 to support the 2006 

formetanate HCl IRED (and 2007 formetanate HCl RED). The IRED required mitigation 

measures to reduce occupational risks below the Agency’s LOC (such as, additional 

protective label language, personal protective equipment (PPE), engineering controls, 

extended restricted entry intervals (REIs), and prohibiting certain applications). 

Cumulative:

The Food Quality Protection Act (FQPA) requires the Agency to consider the cumulative 

risks of chemicals sharing a common mechanism of toxicity. Formetanate HCl is a 

member of the N-methyl carbamate common mechanism group. The most recent 

cumulative risk assessment for the NMC carbamates was issued on September 26, 2007 

and is available at http://www.epa.gov/oppsrrd1/REDs/nmc_revised_cra.pdf. 

Use of Studies with Human Subjects:

Past formetanate HCl risk assessments relied in part on data from studies in which adult 

human subjects were intentionally exposed to a pesticide to determine their dermal and 

inhalation exposure. Many such studies, involving exposure to many different pesticides, 

comprise generic pesticide exposure databases such as the Pesticide Handlers Exposure 

Database (PHED) and the Agricultural Reentry Task Force (ARTF) Database. EPA has 

reviewed all the studies supporting these multi-pesticide generic exposure databases, and 

has found no clear and convincing evidence that the conduct of any of them was either 

fundamentally unethical or significantly deficient relative to the ethical standards 

prevailing at the time the research was conducted. All applicable requirements of EPA’s 

Rule for the Protection of Human Subjects of Research (40 CFR Part 26) have been 

satisfied, and there is no regulatory barrier to continued reliance on these studies.
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Incident Reports:

The Agency’s evaluation of the OPP Incident Data System (IDS) did not identify any 

human health incidents in the United States from 2002 to the present for formetenate 

HCl.

The Centers for Disease Control and Prevention/National Institute for Occupational 

Safety and Health Sentinel Event Notification System for Occupational Risk 

(CDC/NIOSH SENSOR) database identified three occupational cases where-in workers 

(one mixer/loader and two applicators) were exposed to formetanate HCl. In all cases, 

the individuals indicated dermal, gastrointestinal and neurological symptoms. These 

exposures were categorized as low to moderate severity.

The Ecological Incident Information System (EIIS, version 2.1), which is maintained by 

the Agency’s Office of Pesticide Programs, and the Avian Monitoring Information 

System (AIMS), which is maintained by the American Bird Conservancy, indicated no 

reported ecological incidents associated with the use of formetanate HCl.

Tolerances and International Harmonization:

Tolerances are established in 40 CFR § 180.276 for residues of formetanate HCl in or on 

apple; pear; peach; nectarine; orange; lemon; lime; grapefruit; tangelo and tangerine.

Canada has established maximum residue limits (MRLs) for formetanate HCl but they 

are not harmonized with all US tolerances. The Codex Alimentarius Commission has not 

currently established MRLs for formetanate HCl. The Agency will work to harmonize 

tolerances/MRLs, where possible, during registration review.

Data Call-In Status:

In June of 2008, the Formetanate HCl RED generic data call-in (GDCI) was issued. Data 

required through this DCI remain outstanding, and include the following studies.

Toxicology:

o 870.3465 (90-day) Inhalation Study

 Residue Chemistry:

o 860.1300 Nature of the Residue - storage stability of peach leaves (to support the 

storage stability of peach extract)

o 860.1500 Crop Field Trials: Apple (4 trials), Pear (2 trials), Peach (2 trials), 

Nectarine (confirmatory data), Citrus (5 orange trials, 1 lemon trial, and 2 

grapefruit trials)
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Labels:

Formetanate HCl labels can be obtained from the Pesticide Product Label System (PPLS) 

website: http://oaspub.epa.gov/pestlabl/ppls.home. A summary of formetanate HCl 

labels is provided in the table below.

Formetanate Hydrochloride Products

Registration

Number

Product Name Active Ingredient

10163-264 Formetanate Hydrochloride Technical 92%

10163-265 Carzol SP Miticide/Insecticide in 

Water Soluble Packaging

92%