**Exhibit
      31.1**




**CERTIFICATIONS**




I,
        John
        Thode, certify that:
  1.
        I have
        reviewed this annual report on Form 10-K of ISCO International,
        Inc.;
  2.
        Based
        on my knowledge, this annual report does not contain any untrue statement
        of a
        material fact or omit to state a material fact necessary to make the statements
        made, in light of the circumstances under which such statements were made,
        not
        misleading with respect to the period covered by this annual
        report;
  3.
        Based
        on my knowledge, the financial statements, and other financial information
        included in this annual report, fairly present in all material respects the
        financial condition, results of operations and cash flows of the registrant
        as
        of, and for, the periods presented in this annual report;
  4.
        The
        registrant’s other certifying officer and I are responsible for establishing and
        maintaining disclosure controls and procedures (as defined in Exchange Act
        Rules
        13a-15(e) and 15(d)-15(e)) for the registrant and have:
  a.
        designed such disclosure controls and procedures or caused such disclosure
        controls and procedures to be designed under our supervision to ensure that
        material information relating to the registrant, including its consolidated
        subsidiaries, is made known to us by others within those entities, particularly
        during the period in which this annual report is being prepared;
  b.
        evaluated the effectiveness of the registrant’s disclosure controls and
        procedures and presented in this annual report our conclusions about the
        effectiveness of the disclosure controls and procedures, as of the end of
        the
        period covered by this annual report based on such evaluation;
  c.
        disclosed in this annual report any change in the registrant’s internal control
        over financial reporting that occurred during the registrant’s most recent
        fiscal quarter that was materially affected, or is reasonably likely to
        materially affect, the registrant’s internal control over financial reporting;
        and
  5.
        The
        registrant’s other certifying officer and I have disclosed, based on our most
        recent evaluation of internal control over financial reporting, to the
        registrant’s auditors and the Audit Committee of the registrant’s board of
        directors (or persons performing the equivalent functions):
  a.
        all
        significant deficiencies and material weaknesses in the design or operation
        of
        internal control over financial reporting which are reasonably likely to
        adversely affect the registrant’s ability to record, process, summarize and
        report financial information; and
  b.
        any
        fraud, whether or not material, that involves management or other employees
        who
        have a significant role in the registrant’s internal control over financial
        reporting.




**ISCO
              International, Inc.**Date: March
              30, 2007
            By:
            /s/ **JOHN
                THODE***John
              Thode***
            *Chied
                Executive Officer*