### SAT Report PMN Number: P-13-0078 SAT Date: 11/9/2012 Print Date: 1/7/2013

Related cases :

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 2-3 2

Persistence Bioaccum Toxicity Comments 1 12

Exposure Based Review : Health: Yes Ecotox: N o
Routes of exposure : Health: Dermal Drinking Water Inhalation Ecotox: All releases to water Fate: ;
Keywords : Keywords: ACUTE, IRR-S,E, KIDNEY, LIVER, REPRO-M, ADRENAL, DEVEL
Summary of Assessment :

Fate : Fate Summary: P-13-0078 FATE: Liquid with MP < 20 C (E) log Kow = -1.12 (E) S > 10 g/L at 25 C (E) VP = 4.2E-4 torr at 25 C ( N OMO5) BP = 317 C (M) H < 1.00E-8 (E) log Koc = 1.38 (E)log Fish BCF = 0.50 (E) log Fish BAF = -0.05 (E) POTW removal (%) = 0-25 via biodeg; OECD 301F(Mano Resp): 1-3%/28d N RB. Time for complete ultimate aerobic biodeg = wk-mo Sorption to soils/sediments = low PBT Potential: P1B1 *CEB FATE: Migration to ground water = rapid

Health : Health Summary: Absorption is poor through the skin based on p hysical/chemical properties and good through the lungs and GI tract based on analogs. There is concern for moderate acute toxicity, irritation/corrosion to all exposed tissues, kidney toxicity, liver toxicity, effects to the adrenals, and reproductive toxicity to males based on test data for an analog Moderate high concern. Test Data: TEST DATA for analog,

negative in Salmonella with and without activation negative in mouse micronucleus assay , ip negative in a rat hepatocyte unscheduled DNA synthesis assay acute oral study in rats - deaths at 400 mg/kg and greater; no deaths at 320 mg/kg; LD50 = 573 mg/kg in females; signs of stomach irritation in animals that died; decreased activity, salivation, diarrhea, p tosis, p oor grooming, p iloerection, abnormal stance, abnormal gait, dyspnea, p rostration acute dermal study in rabbits - LD50 = 750 mg/kg, necrosis of the skin at the site of application not a dermal sensitizer in guinea pigs corrosive to the eye in rabbits corrosive to the skin in rabbits dermal developmental toxicity study in rabbits (0.1 ml applied of a 1, 5, or10% concentration- no deaths; decrease in maternal body weight gain at 10% concentration; severe skin irritation at 5 and 10% concentration; increase in kidney weights at 10% concentration; histopathological changes in the kidneys at 5 and 10% concentration; increase in liver weights in all dose groups; decrease in litter weights and female fetal weights at 10% concentration acute inhalation study in rats (2.204 mg/L) - LC50 > 2.204 mg/L; 1 animal sacrificed in moribund condition and Day 5; signs of irritation

Test DATA for same analog submitted with rat acute oral LD50 = 677 mg/kg; rabbit acute dermal LD50 = 0.25 to 0.63 mL/kg; rat acute inhalation LC100 = 200 p p m , LC0 = 68 p p m , with toxic signs to lungs and eyes; rat acute inhalation LC20 = 149 p p m ; rat acute inhalation LC50 = 166 p pm calculated from several tests; rat 6-h acute inhalation LC50 = 117 p pm with possible neurotoxic signs rat skin irritation test: moderate irritation in 3 min, severe irritation and corrosion in 60 min

human skin irritationnegative skin sensitization in guinea pigs at 4% induction, 2% 1st challenge, and 1% re-challenge moderate eye irritation in rabbits at 5% ai and higher, no irritation at 1% ai; rabbit eye irritation test via exposure to vapor for 2 h: 10 p p m = severe eye irritation, 1 p p m = no significant irritation; rat 7-d oral toxicity test via diet NOEL = 0.15 mg/kg/d, LOEL = 0.22 mg/kg/d based on reduced body weight and kidney toxicity, at 0.33 mg/kg/d = liver toxicity, reduced body weight, and kidney toxicity; rat 9-d dermal toxicity test via 1 mL for 6 h/d at 10% ai, 5% ai, and 2.5% ai: LOEL = 2.5% ai based on irritation at site of application and kidney toxicity, at 5% ai = decreased body weight, irritation and necrosis at site of application, and kidney toxicity, and at 10% ai = necrosis at site and kidney toxicity rat 9-d inhalation at 90 p p m , 40 p p m , and 20 p pm with LC100 at 90 p pm an d 40 p p m , and irritation to all exposed tissues at all doses; rat 9-d inhalation at 20 p p m , 10 p p m , and 1 p pm with NOEC = 1 p p m , LOEC = 10 p pm based o n irritation, at 20 p pm irritation and blood toxicity ; rat 9-d inhalation test showed death at 47 p p m rat 14-wk=90-d inhalation toxicity test at 5.8 p p m , 1.25 p p m , and 0.220 p pm fo r 5 d/wk NOEC = 1.25 p p m , LOEC = 5.8 p pm based on reduced body weight, and effects to the adrenals and testes; rabbit 90-d dermal toxicity test at 1 mL of 2% ai, 0.7% ai, and 0.2% ai for 5 d/wk = 20 mg/kg/d, 7.5 mg/kg/d, and 2.5 mg/kg/d showed moderate skin irritation at all doses, no systemic toxicity

rat dermal developmental toxicity test at 10%ai, 5%ai, and 1%ai showed fetal LOEL = 10%ai, fetal NOEL = 5%ai, maternal NOEL = 1%ai, and maternal LOEL = 5%ai based on severe skin irritation; Ames test was negative; CHO forward gene mutation test negative; mouse micronucleus test via ip was negative rat hepatocyte unscheduled DNA synthesis was negative; SCE with CHO cells was negative; mouse in vivo peripheral micronucleus test negative;

Ecotox :

Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 >100 daphnid 48-h LC50 >100 green algal 96-h EC50 >100 23 fish

_ chronic value >10 daphnid

_ chronic value >10

algal

_ chronic value >10 5.7Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for ; SAR chemical class = ; MW 261; liquid; log Kow = -0.42 (EPI); S > 1000 g/L at 25 C (P); p H7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness < 150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 570

SARs SAR Class Ecotox Category

Ecotox Factors Comments:

SAT Chair: Becky Jones