c54382_ex10-2.htm -- Converted by SEC Publisher, created by BCL Technologies Inc., for SEC Filing





Exhibit 10.2



CONFIDENTIAL TREATMENT REQUESTED


CONFIDENTIAL TREATMENT REQUESTED: INFORMATION FOR WHICH
CONFIDENTIAL TREATMENT HAS 

BEEN REQUESTED IS OMITTED AND IS NOTED AS FOLLOWS **REDACTED**. AN


UNREDACTED VERSION OF THIS DOCUMENT HAS BEEN FILED
SEPARATELY WITH THE SECURITIES AND 

EXCHANGE COMMISSION. 


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LICENSE AGREEMENT


     THIS LICENSE AGREEMENT (the “Agreement”) is entered into this 30th day of September 2005 (the “Effective Date”) by and between NatImmune A/S, a Danish corporation with offices at Fruebjergvej 3, Box 3, DK-2100, Copenhagen, Denmark
(“NatImmune”), and ENZON PHARMACEUTICALS, INC., a Delaware corporation with offices at 685 Route 202/206, Bridgewater,
New Jersey 08807 (“Enzon”). NatImmune and Enzon may be referred to herein individually as a “Party” or
collectively, as the “Parties.”


RECITALS 


     WHEREAS, Enzon is a pharmaceutical company engaged in the discovery, development, marketing, manufacture and distribution of pharmaceutical products, including
Pegylated pharmaceutical compositions; 


     WHEREAS, NatImmune is a pharmaceutical company engaged in the discovery of processes and methods of producing recombinant human mannan-binding lectin;
and 


     WHEREAS, NatImmune and Enzon desire to enter into a relationship pursuant to which Enzon will Develop and Commercialize pharmaceutical compositions containing recombinant human
mannan-binding lectin. 


      NOW, THEREFORE, in consideration of the foregoing and the covenants and promises contained in this Agreement, the Parties agree as follows: 











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      1.   DEFINITIONS 



           1.1  “Affiliate” means a person, corporation, partnership, or other entity that controls,
is controlled by or is under common control with a Party. For the purposes of
this Section, the word “control” (including, with correlative meaning, the terms “controlled by” or “under the common
control with”) means the ownership, directly or indirectly, of at least
fifty percent (50%) of the voting rights or other ownership interests of such
entity. 


           1.2   “Baltic Countries” means Estonia, Latvia and Lithuania. 



           1.3   “BLA” means a biologic license application or other application seeking approval from a Regulatory Authority to sell a Product in a country or other geographic territory.


           1.4    “Business Day” means a day other than a Saturday, Sunday, bank or other public holiday in the state of New Jersey. 


           1.4b   “Change in Control” means, with respect to a Party, an event where: 


               (a) any Person or group of Persons (as the term “group” is interpreted pursuant to Rule 13d-5 under the Securities Exchange Act of 1934, as amended) acquires beneficial ownership of capital
stock of the Party (other than (x) directly from such Party or (y) from underwriter(s) of such Party’s capital stock in a public offering) entitling the holder(s) thereof to at least a majority of the voting power of the then outstanding
capital stock of such Party with respect to the election of directors of such Party, or


               (b) the Party enters into a merger, consolidation, reorganization or similar transaction with another Person (the “Acquiring
Corporation”) in which less than a majority of the voting power of the outstanding capital stock of such Party (if it is the surviving entity) or of


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the Acquiring Corporation (if it is the surviving entity) with respect to the election of directors following such transaction is held by Persons who were shareholders of such Party immediately prior to such transaction, or


               (c) the Party sells to any Person(s) in one or more related transactions properties or assets representing
all or substantially all of the properties and assets of such Party. 


           1.5   “Combination Product” means a Product that (a) contains rhMBL with one or more other
pharmaceutically active ingredients, (b) contains PEG-rhMBL with one or more other pharmaceutically active ingredients, or (c) contains an MBL Derivative with one or more other pharmaceutically active ingredients. 


           1.6   “Commercialize” or “Commercialization” means
all activities that are undertaken after  approval of a BLA for a particular
Product and that relate to the commercial marketing and sale of such Product,
including advertising, marketing, promotion, distribution, and Phase IV Trials. 


           1.7   “Compound” means rhMBL, PEG-rhMBL or an MBL Derivative.

           1.8   “Confidential
  Information” means, with respect
    to a Party, all non-public, proprietary
    data or information and materials received by either Party from the other Party
    pursuant to this Agreement and that is designated as “Confidential Information” by
    such Party at the time of disclosure or promptly thereafter, subject to the exceptions
    set forth in Section 6.2.


           1.9  “Control” or “Controlled” means,
with respect to any intellectual property right, that a Party owns or has a license
to such item or right, and has the ability to grant a license or sublicense in
or to such right without violating the terms of any agreement or  other arrangement
with any Third Party. 


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           1.10  “Current Product” means the existing
  formulation of a Product containing rhMBL that (a) is prepared using the manufacturing process that will be used by Diosynth B.V. to produce Product for the upcoming Phase Ib clinical trial (as further described in Schedule
1.10a), and (b) that is used for any of the indications set forth on Schedule 1.10b. 


           1.11  “Develop” or “Development” means, with respect to the Product, the performance of all
research, pre-clinical, clinical, process and formulation development and regulatory activities required to obtain Regulatory Approval of a Product in the Territory. 


           1.12  “Development Data” means all preclinical, formulation, process and clinical development data,
including toxicological data and regulatory information, relating to a Compound or Product that is Controlled at any time during the Term by either Party or any of its Affiliates.


           1.13  “Development Plan” shall have the meaning set forth in Section 3.1(d).



           1.14  “Diligent Efforts” means efforts that are not less than those efforts a Party makes with respect to other products in its portfolio (but, in any event, not less than the efforts that would be exerted by a reasonably prudent and diligent biopharmaceutical company similarly situated such Party to accomplish
similar objectives), taking into account, among other things, the product's labeling (target or actual) and market potential, competitive market conditions in the therapeutic area, regulatory environment and other relevant factors at the time such
efforts are due. 


           1.15  “Diosynth Agreement” means the BIOPROCESSING SERVICES AGREEMENT dated as of 15 December 2004, between NatImmune and Diosynth B.V.


           1.16   “EMEA” means the European Medicines Agency and/or the Committee for Proprietary Medicinal Products or any successor agency thereof. 


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           1.17  “Enzon Know-How” means all Know-How that
  is: (a) Controlled by Enzon or
  its Affiliates as of the Effective Date or acquired or developed by or on behalf of Enzon during the Term, and (b) necessary or useful for the development, manufacture, use or sale of Compounds or Products.       

           1.18   “Enzon Patents” means any Patents that: (a) are Controlled by Enzon
  or its Affiliates as of the Effective Date or claim inventions acquired or made by or on behalf of Enzon during the Term, and (b) are necessary or useful for the development, manufacture, use or sale of Products.  

           1.19  “Enzon Quarter” means each of the three (3) month periods commencing 
  January 1, April 1, July 1 and October 1 of each calendar year.   

           1.20  “Enzon Technology” means Enzon Patents and Enzon Know-How.            

           1.21  “Enzon Territory” means all countries and other geographic territories of the
  world except the NatImmune Territory.  

           1.22  “EU” means the European Union, as it may be expanded or contracted from 
  time-to-time.   

           1.23  “FDA” means the United States Food and Drug Administration, or any 
  successor federal agency thereto.  

           1.24  “Field” means use in humans for any indications other than the use (a) as a 
  component (including a reagent) of a needle-free glucose sensor or similar medical device, or
  (b) through Topical Administration.

           1.25  “Generic
  Product” means any pharmaceutical
    product, other than a Product,
  that contains the same active ingredient(s) as
  the relevant Product and is approved for use for


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the same indication or indications as such Product under an ANDA or similar abridged 
  marketing authorization that is based on the clinical data for such Product.       

           1.26  “Good Clinical Practices” or “GCP” means current Good Clinical Practices as specified
  in the United States Code of Federal Regulations, at the time of testing, and all FDA and ICH guidelines, including the ICH Consolidated Guidelines on Good Clinical Practices.      

           1.27  “Good Laboratory Practices” or “GLP” means current Good Laboratory Practices as
    specified in the United States Code of Federal Regulations at 21 CFR § 58 at the time of testing and all applicable ICH guidelines.      

           1.28  “Good Manufacturing Practices” or “GMP” means current Good Manufacturing Practices
      and standards as provided for (and as amended from time to time) in European Community Directive 91/356/EEC (Principles and Guidelines of Good Manufacturing Practice for Medicinal Products) and in the Current Good Manufacturing Practice Regulations
      of the United States Code of Federal Regulations Title 21 (21 CFR §§ 210-211) in relation to the production of pharmaceutical intermediates and active pharmaceutical ingredients, as interpreted by ICH Harmonized Tripartite Guideline, Good
      Manufacturing Practice Guide for Active Pharmaceutical Ingredients.  

           1.29  “Governmental
      Authority” means any court,
      agency, department or other 
  instrumentality of any foreign, federal, state,
  county, city or other political subdivision.

           1.30  “IND” means
  an Investigational New Drug Application filed with the FDA or the equivalent
  application or filing filed with any equivalent agency or government authority
  outside of the United States (including any supra-national agency such as in
  the European Union) necessary to commence human clinical trials in such jurisdiction,
  and  including all regulations at 21 CFR § 312 et. seq. and equivalent
  foreign regulations.


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           1.31  “Invention”
  means all inventions, discoveries and improvements (whether or 
  not patentable) that are: (a) Controlled by either Party or its Affiliates as of the Effective Date or are acquired or conceived during the Term, and (b) necessary or useful to develop, make, use or sell any Product.      

           1.32  “Know-How” means any non-public, proprietary information and other data, instructions,
      processes, methods, formulae, materials, expert opinions, results, databases, inventions, practices, techniques, specifications, and know-how, including pharmacological, biological, chemical, biochemical, toxicological, pharmaceutical, physical,
  analytical, clinical, safety, manufacturing, quality control data, and stability data.       

           1.33  “Launch” means the first shipment of a Product in commercial quantities for commercial sale by
  Enzon, its Affiliates or its Sublicensees to an unaffiliated Third Party in a country after receipt by Enzon of the first Regulatory Approval for such Product in such country.   

           1.34  “Law” or “Laws” means all applicable Laws, statutes,
  rules, regulations, 
  orders, codes, judgments and/or ordinances of any Governmental Authority.   

           1.35  “Major EU Country” means Italy, France, Spain, Germany or the United 
  Kingdom.   

           1.36  “MBL Derivatives” means molecules containing human mannan-binding 
  lectin sequences, as such molecules are described in patent application [**Redacted**].   

           1.37  “Native Product” means a Product that does not contain PEG-rhMBL or a 
  Pegylated MBL Derivative.   

           1.38  “NatImmune Know-How” means all Know-How that is: (a) Controlled by 
  NatImmune or its Affiliates as of the Effective Date or acquired or developed by or on behalf 


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of NatImmune during the Term and (b) necessary or useful for the development, manufacture,
  use or sale of Compounds or Products.       

           1.39 “NatImmune Patents” means any Patents: (a) Controlled by NatImmune or its Affiliates as of the
  Effective Date or that claims inventions acquired by or made by or on behalf of NatImmune during the Term; and (b) that are necessary or useful for the development, manufacture, use or sale Compounds or of Products, including the Patents listed on
  Schedule 1.39.  

           1.40  “NatImmune Technology” means NatImmune Patents and NatImmune Know-How. 

           1.41  “NatImmune Territory” means Denmark, Finland, Iceland, Norway and 
  Sweden.  

           1.42  “Net Sales” means:      

           (a) with respect to a Product (subject to subsections (b) and (c) below), the amount invoiced by Enzon or its Affiliates (or, with respect to
  the United States, by Enzon, its Affiliates or its Sublicensees), for sales of such Product to Third Parties, less (i) actual bad debts directly related to sales of a Product; (ii) sales returns and allowances actually paid, granted or accrued,
  including trade, quantity and cash discounts; (iii) credits and refunds in connection with price adjustments, billing errors, rejected goods, damaged or defective goods, recalls, and returns; (iv) rebates, chargeback rebates, reimbursements or
  similar payments granted or given to wholesalers or other distributors, buying groups, health care insurance carriers, governmental or regulatory authority, government-subsidized program or managed care organization or other institutions, and
  adjustments arising from consumer discount programs; (v) customs or excise duties, sales tax, consumption tax, value-added tax, and other


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 taxes (except income taxes) or duties relating to sales; and (vi) and freight and insurance (to 
  the extent that Enzon bears the cost of freight and insurance for a Product); and       

           (b)  Net Sales of any Product that is sold as a Combination Product in a particular country will be determined by multiplying the total Net
  Sales of the Combination Product by the fraction A/(A+B), where A is the average invoice price per unit dose of the Product when sold separately in finished form in such country and B is the sum of the average invoice prices of the products
  containing the other active ingredients in the Combination Product when sold separately in finished form in such country. In the event that such average invoice price cannot be determined for both the Product and the product(s) containing such other
  ingredient(s), the Parties will negotiate in good faith regarding the calculation of Net Sales for the applicable Combination Product, based on the relative value contributed by each component.      

           1.43  “Patent” means: (a) an issued, unexpired patent (including inventor's certificate), including
    any substitution, extension, supplementary protection certificates, registration, confirmation, reissue, reexamination, renewal or any like filing thereof; or (b) any pending patent application, including any continuation, division or
    continuation-in-part thereof and any provisional application.       

           1.44  “Pegylation” with a correlative meaning for “Pegylated,” means the conjugation
  (covalent chemical bonding) of PEG (including conjugation through linking groups) with or to other materials, including single chain antibodies. “Pegylation” will include the synthesis, derivatization, characterization, and modification of
  PEG for such purposes, together with the synthesis, derivatization, characterization, and modification of the raw materials and intermediates for the manufacture of PEG reagents or products incorporating 


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 such PEG reagents by means of conjugation, and all methods of making and using each and all
  of the foregoing. For clarity, Pegylation will not include the attachment of PEG with or to other materials by means other than conjugation. As used in this definition, “PEG” means polyethylene glycol and derivatives thereof, including methoxy-polyethylene glycol.  

           1.45  “Pegylated Product” means a Product that contains PEG-rhMBL or the 
  Pegylated form of an MBL Derivative.   

           1.46  “PEG-rhMBL” means a Pegylated form of rhMBL.   

           1.47  “Person” means an individual, corporation, partnership, company, joint
  venture, unincorporated organization, limited liability company or partnership, sole proprietorship, association, bank, trust company or trust, whether or not legal entities, or any governmental entity or agency or political
subdivision thereof.      

           1.48  “Phase II Trial” means a clinical trial of a Product on patients, the principal purpose of
  which is to establish clinical proof of principle and to obtain sufficient information about such Product’s efficacy to permit the design of further clinical trials, and that would satisfy the requirements of 21 CFR § 312.21(b).
      

           1.49  “Phase III Trial” means a clinical trial that provides for a pivotal human clinical trial of a
    Product, which trial is designed to: (a) establish that a Product is safe and efficacious for its intended use; (b) define warnings, precautions and adverse reactions that are associated with the Product in the dosage range to be prescribed; (c)
support Regulatory Approval of such Product; and (d) that would satisfy the requirements of 21 CFR § 312.21(c).      

           1.50  “Phase IV Trial” means clinical trial of a Product commenced in a particular country after
  Regulatory Approval for such Product in such country in order to support commercialization of the Product. 


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           1.51   “Product” means any pharmaceutical
  product (except those delivered via 
  Topical Administration) that contains a Compound, including any Combination Product. 

           1.52  “Product Trademarks” means one or more
  trademarks or logos that are used for the marketing and sale of a Product. Product Trademark does not include the logo or tradename of either Party, their Affiliates or the trademark or tradename of another product sold by either Party.       

           1.53  “Regulatory Approval” means any and all approvals (including supplements, amendments, pre- and
        post-approvals, and pricing and reimbursement approvals even if such pricing and reimbursement approvals are not legally required to sell the applicable Product), licenses, registrations or authorizations of any national, supra-national (e.g., the
        European Commission or the Council of the European Union), regional, state or local regulatory agency, department, bureau, commission, council or other governmental entity, that are necessary for the manufacture, distribution, use or sale of a
  Product in a regulatory jurisdiction.       

           1.54  “Regulatory Authority” means any Governmental Authority with responsibility for granting any
          licenses or approvals necessary for the marketing and sale of pharmaceutical products, including the FDA and any equivalent regulatory authority of countries of the European Union and Japan, and where applicable any ethics committee or any
  equivalent review board.       

           1.55  “Regulatory Filing” means a BLA, IND, or any foreign counterparts thereof and any other filings
  required by Regulatory Authorities relating to the study, Development and Commercialization of any Product.   

           1.56  “rhMBL” means recombinant human mannan-binding lectin encoded by the 
  gene sequence for human mannan-binding lectin, as more fully described in [**Redacted**]. 


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           1.57  “Royalty Term” means on a
  country-by-country and Product-by-Product basis,
  the later of: (a) the last to expire Valid Claim of a NatImmune Patent covering such Product in such country, and (b) twenty (20) years following the first Launch of such Product in such country.      

           1.58  “Sublicensee” means a Third Party to whom Enzon grants a sublicense
      under any rights licensed hereunder to distribute, promote the sale of and sell the Products, or otherwise grants rights to distribute, promote and sell the Products (other than wholesalers and physical distributors). Solely for purposes of the
      definition of Net Sales, further sublicenses by permitted Sublicensees of United States rights shall be considered Sublicensees.   

           1.59  “Term” has the meaning assigned to it in Section 7.1.   

           1.60  “Third Party” means a person or entity other than Enzon, NatImmune or an
  Affiliate of either of them.   

           1.61  “Third Party Licenses” means the license agreements entered into by 
  NatImmune that are listed on Schedule 1.61.      

           1.62  “Topical Administration” means the topical administration, whether
      through ointments, gels, creams, lotions, or other similar formulations, of a pharmaceutical product, including administration directly to the external epidermis, dermis, mucous membrane or the eye of a subject, but excluding intrapulmonary
      administration and intranasal administration.  

           1.63  “United States” means the United States of America, its territories and 
  possessions, including the commonwealth of Puerto Rico.       

           1.64  “Valid Claim” means a claim of any issued, unexpired NatImmune Patent that has not been
  dedicated to the public, disclaimed, abandoned or held invalid or unenforceable by a court or other body of competent jurisdiction in an unappealed or unappealable decision, 


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 and that has not been explicitly disclaimed, or admitted by NatImmune in writing to be invalid
  or unenforceable or of a scope not covering Products through reissue, disclaimer or otherwise. 

           1.65  “Year” means a twelve-month
  period commencing January 1 and ending December 31.  

2.   LICENSES AND RELATED RIGHTS

      2.1   Licenses to Enzon. Subject to the terms of this Agreement, NatImmune grants
  to Enzon the following:      

           (a) an exclusive license (except as to NatImmune), including the right to sublicense to the extent permitted under Section 2.5,
  under the NatImmune Technology and NatImmune’s rights in any Joint Patents (as defined in Section 5.2(a)) to make and have made in the NatImmune Territory, Compounds and Products for use in the Field, except that Enzon may only sell and offer
  for sale such Compounds and Products in the Enzon Territory; 

           (b) an exclusive (even as to NatImmune) license in the Enzon Territory, including the right
  to sublicense to the extent permitted under Section 2.5, under the NatImmune Technology and NatImmune’s rights in any Joint Patents, to make, have made, develop, promote, use, import, offer for sale and sell Compounds and Products for use in
  the Field, 

           (c) Each of the foregoing licenses to Enzon under the NatImmune Technology licensed to NatImmune under Third Party Licenses is subject to (i)
  the rights reserved under such Third Party Licenses, including non-exclusive licenses to use for internal, non-commercial research purposes and the rights of the United States government; and (ii) the other terms and conditions of such Third Party
  Licenses that are expressly required to apply to a sublicense thereunder, as contained in the copies of such Third Party Licenses provided to Enzon prior to the date hereof. Enzon agrees that it shall not, and shall cause its Affiliates and
  licensees to 


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not, (a) solicit active or passive sales of Compounds or Products outside the Enzon Territory, 
  or (b) sell Compounds or Products to Third Parties where Enzon knows or should reasonably know that such Third Parties intend to resell such Compounds or Products outside of the Enzon Territory.   

      2.2  Licenses to NatImmune.      

           (a) Enzon hereby grants to NatImmune the exclusive (even as to Enzon) license in the NatImmune Territory (including the right to
  sublicense with Enzon’s consent, such consent not to be unreasonably delayed, withheld or conditioned), under the Development Data, Regulatory Approvals and Product Trademarks to promote, use, import, offer for sale and sell Compounds and
  Products for use in the Field. NatImmune agrees that it shall not, and shall cause its Affiliates and licensees to not, (a) solicit active or passive sales of Compounds or Products outside the NatImmune Territory, or (b) sell Compounds or Products
  to Third Parties where NatImmune knows or should reasonably know that such Third Parties intend to resell such Compounds or Products outside of the NatImmune Territory.      

           (b) In the event NatImmune decides to seek to grant a sublicense (including granting a right to promote the sale of a Product)
  for rights to a Product or Products in one or more countries in the NatImmune Territory (“NatImmune Sublicense”), NatImmune will first notify Enzon of such decision, (the
  “NatImmune Sublicense Notice”), and Enzon will have twenty (20) days from its receipt of the NatImmune Sublicense Notice to decide whether it wishes to pursue negotiations with
  NatImmune to enter into a NatImmune Sublicense with NatImmune.   

           (c) If Enzon declines to enter into negotiations or does not reply to the NatImmune 
  Sublicense Notice within such twenty (20) day period, NatImmune shall be free to enter into a 


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NatImmune Sublicense agreement with a Third Party and shall have no further obligations to 
  Enzon with respect to such NatImmune Sublicense.       

           (d) If Enzon notifies NatImmune that it is interested in acquiring such rights within such twenty (20) day period, then for an
  additional forty (40) day period, NatImmune shall conduct negotiations on an exclusive basis with Enzon diligently and in good faith to reach a written agreement with Enzon, provided that neither Party shall be obligated to enter into such written
  agreement and failure to enter into such written agreement shall not be considered a breach of this Section 2.2. If the Parties fail to sign a written agreement within such forty (40) day period, NatImmune shall be free to enter into a NatImmune
  Sublicense agreement with a Third Party.       

     2.3  Baltic Country Co-Promotion. Enzon hereby grants to NatImmune the exclusive right to market,
    promote and detail (but not to sell) the Products in the Baltic Countries on commercially reasonable terms, which terms will be negotiated by the Parties in good faith in order to reach agreement thereon no later than December 31, 2005.       

     2.4  Rights in Bankruptcy. All rights and licenses granted under or pursuant to this Agreement by
  the Parties are, and will otherwise be deemed to be, for purposes of Section 365(n) of the United States Bankruptcy Code, licenses of rights to “intellectual property” as defined under Section 101 of the United States Bankruptcy Code
  except as may otherwise be required by any provision under Danish insolvency Laws. The Parties agree that the Parties, as licensees of such rights under this Agreement, will retain and may fully exercise all of their rights and elections under the
  United States Bankruptcy Code to the extent not otherwise mandatorily provided for under Danish insolvency Laws. The Parties further agree that, in the event of the commencement of a bankruptcy proceeding by or against a Party under


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the United States Bankruptcy Code, or commencement of insolvency proceeding by or against 
  a Party under the Danish Bankruptcy Act as the case may be, the Party hereto that is not a Party to such proceeding will be entitled to a complete duplicate of (or complete access to, as appropriate) any such intellectual property
and all embodiments of such intellectual property, which, if not already in the non-subject Party's possession, will be promptly delivered to it (a) upon any such commencement of a bankruptcy proceeding upon the non-subject Party's written request
therefore, unless the Party subject to such proceeding continues to perform all of its obligations under this Agreement or (b) if not delivered under clause (a) above, following the rejection of this Agreement by or on behalf of the Party subject to
such proceeding upon written request therefore by the non-subject Party.      

     2.5  Topical Administration. NatImmune retains all rights to Topical Administration of Compounds
  and, accordingly, retains the exclusive right to develop and commercialize a pharmaceutical products that contain a Compound for Topical Administration (a “Topical Product”), provided, however, that NatImmune may not develop a Compound for (a) any therapeutic use in the fields of internal organ transplant or
    oncology; or (b) for the delivery of a compound where the pharmacologic action is effected primarily by systemic, as opposed to local, administration. If NatImmune decides to seek to grant a license (including granting a right to promote the sale of
    and resell a Topical Product manufactured by or for NatImmune) for rights to a Topical Product in the United States of America (“U.S. Topical License”) prior to the [**Redacted**]:       

           (a) NatImmune will first notify Enzon of such decision, and will simultaneously provide Enzon with all material information
  regarding the formulation, stability, safety and efficacy of such Topical Product and its backups, if any; the status of discussions with FDA or 


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any Regulatory Authorities directly relating thereto; and relevant patent information (together,
  the “Topical Notice”). Enzon will have twenty (20) days from its receipt of the Topical Notice to decide whether it wishes to pursue negotiations with NatImmune
to enter into a U.S. Topical License with NatImmune; 

           (b) If Enzon declines to enter into negotiations or does not reply to the Topical Notice within
  such twenty (20) day period, NatImmune shall be free to enter into a U.S. Topical License agreement with a Third Party and shall have no further obligations to Enzon with respect to such U.S. Topical License; and 

           (c) If Enzon notifies NatImmune that it is interested in acquiring such rights within such twenty (20) day period, then for an additional forty (40) day period,
    NatImmune shall conduct negotiations on an exclusive basis with Enzon diligently and in good faith to reach a written agreement with Enzon, provided that neither Party shall be obligated to
    enter into such written agreement and failure to enter into such written agreement shall not be considered a breach of this Section 2.5. If the Parties fail to sign a written agreement within such forty (40) day period, NatImmune shall be free to
    enter into a U.S. Topical License agreement with a Third Party.       

     2.6  Sublicenses. Subject to Section 4.11 and, in the case of the United States, Section 4.12,
  Enzon may grant sublicenses under the licenses granted under Section 2.1, or other grants of rights to a Sublicensee (a “Sublicensee Arrangement”) without the prior written consent
  of NatImmune; provided, that in the case of each such Sublicensee Arrangement, (a) Enzon shall be liable to NatImmune as if Enzon is exercising such sublicensed rights itself under this
  Agreement, including all payment, diligence and reporting obligations; (b) Enzon shall provide all reasonable assurances that its Sublicensees comply 


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with confidentiality, indemnity, reporting, audit rights, access to data (including Development 
  Data and regulatory filings), and information obligations comparable to those set forth in this Agreement; (c) with respect to the Major EU Countries and the United States, Enzon maintains an active role in the development and
commercialization strategy for the Product; and (d) Enzon promptly provides to NatImmune copies of each Sublicensee Arrangement.      

      2.7  Exclusivity. During the Royalty Term in each country, neither Enzon and its Affiliates nor
  NatImmune and its Affiliates shall, except pursuant to this Agreement, directly or indirectly, by itself or with any Third Party, Commercialize in such country any pharmaceutical product containing a compound that (a) binds to [**Redacted**]; and (b) activates the complement pathway through [**Redacted**]; and (c) mediates 
  [**Redacted**] and clearance by [**Redacted**].       

     2.8  Exchange of Information. In accordance with a technology transfer schedule to be established
  within 30 days after execution of this Agreement, NatImmune shall disclose to Enzon all NatImmune Know-How not previously disclosed. In addition, from time-to-time throughout the Term,
    NatImmune shall disclose to Enzon all newly-developed or acquired NatImmune Know-How not previously disclosed.  

3.  DEVELOPMENT AND COMMERCIALIZATION 

     3.1  Development.

           (a) For the initial twelve (12) month period after the Effective Date, NatImmune and
  Enzon will meet at least once every other month or as otherwise agreed upon by the Parties in order to discuss the Development of Compounds and Products. Thereafter, until approval of the BLA for the first Product, representatives
  of NatImmune and Enzon will meet at least once every six (6) months or as otherwise agreed upon by the Parties in order to discuss the 


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 Development of Compounds and Products. The site for such meetings will be alternated 
  between sites selected by each Party, with Enzon selecting the site of the first such meeting. In
  lieu of in-person meetings, meetings may take place by telephone or video conference.       

           (b) In its initial Development activities, Enzon will use the Native Product. Thereafter, Enzon will utilize Diligent Efforts to
  Develop such Native Product, and at all times will use Diligent Efforts to Develop at least one Product in accordance with the Development Plan. Enzon shall provide semi-annual written reports to NatImmune sufficient to keep NatImmune fully-informed
  regarding continuing Development activities and plans for the Products.      

           (c) NatImmune shall assign to Enzon, and Enzon shall assume all the rights and obligations of, the Diosynth Agreement. Until such
    time as either (i) the Diosynth Agreement has been assigned by NatImmune to Enzon, or (ii) Diosynth or its affiliate and Enzon have entered into an agreement whose terms are consistent in all material respects to the Diosynth Agreement, NatImmune
    shall obtain for Enzon, at no incremental cost or liability to NatImmune, an arrangement under which Enzon is provided substantially the same benefits under the Diosynth Agreement (subject to all obligations thereunder) as though it were assigned by
    NatImmune to Enzon as of the Effective Date.       

           (d) Development Plan. Enzon shall use Diligent Efforts to prepare a plan for the Development of
  Products to enable the filing and receipt of Regulatory Approval for the Products (such plan, the “Development Plan”). The initial draft Development Plan shall be provided to
  NatImmune promptly after Enzon completes such initial draft, which shall be as soon as reasonably practicable after the Effective Date. The Development Plan will set forth the objectives, planned tasks, and resource allocations for the conduct of
  the Development activities, and shall contain such details as contained Enzon’s regularly prepared development 


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plans for its other products. Enzon shall provide a copy of any proposed material update to the 
  Development Plan to NatImmune before such plan is finalized to enable NatImmune to provide comments thereon. Enzon shall reasonably consider any such comments. During the course of Development, Enzon will update the Development
Plan as it deems necessary and appropriate to reflect the then-current strategy for development of Products.       

           (e)  Development Records. Enzon will also retain all records of its Development activities as
  required by Law. To the extent not otherwise provided for herein, upon reasonable request of NatImmune, Enzon will provide copies of preliminary reports, final reports and all material data and other information relating to or arising out of any
  clinical studies performed by it on Compounds or Products that are required to be submitted in connection with seeking Regulatory Approvals for Products, and any other information or data reasonably requested by NatImmune in connection with the
  Development of Products.       

           (f)  Adverse Events. Promptly following the Effective Date, Enzon and NatImmune will develop and
  agree upon safety data exchange procedures governing the coordination of collection, investigation, reporting, and exchange of information concerning adverse events sufficient to permit each Party, its Affiliates, Sublicensees or licensees to comply
  with its legal obligations. The safety data exchange procedures will be promptly updated if required by changes in legal requirements or by agreement between the Parties. In any event, each Party shall inform the other Party of any Adverse Event of
  which it becomes aware in a timely manner commensurate with the seriousness of the Adverse Event. Enzon will be responsible for reporting all Adverse Events to the appropriate regulatory authorities in the countries in the Enzon Territory, including
  the FDA and EMEA, in accordance with the Laws of the relevant countries and authorities and NatImmune will be responsible for reporting all Adverse Events 


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to the appropriate regulatory authorities in the countries in the NatImmune Territory. Enzon 
  will ensure that its Affiliates and Sublicensees comply with all such reporting obligations, and NatImmune will ensure that its Affiliates and licensees comply with all such reporting obligations. Each Party will designate a
safety liaison to be responsible for communicating with the other Party regarding the reporting of Adverse Events.   

     3.2  Regulatory Affairs.       

           (a) Enzon shall use Diligent Efforts to obtain Regulatory Approvals for at least one Product in the Enzon Territory, including
  compiling, submitting and prosecuting in a timely manner all necessary data, documents and BLAs (including labeling), in a format acceptable to the applicable Regulatory Authorities in the Enzon Territory, maintaining and renewing the Regulatory
  Approvals in the Enzon Territory and paying all user fees and other costs required to obtain and maintain such Regulatory Approvals.       

           (b) Enzon shall grant NatImmune, its Affiliates and licensees the exclusive right to use and cross-reference any Regulatory
    Filings as may be required solely to allow NatImmune, its Affiliates and licensees to sell the Products in the NatImmune Territory and to allow NatImmune, its Affiliates and its licensees to Commercialize the Products in the NatImmune Territory to
    the extent otherwise permitted under this Agreement. Enzon shall transfer to NatImmune, its Affiliates or licensees a copy of the all Regulatory Filings submitted by Enzon to the FDA, EMEA and any other applicable Regulatory Authorities.      

           (c) Enzon shall grant NatImmune the right to use and reference the results generated from Phase IV Trials conducted by or for
  Enzon for a Product in connection with the Commercialization of Products in the NatImmune Territory.


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           (d) In conducting any Development activities hereunder, each Party shall: (i) ensure that its employees, agents, clinical
  institutions and clinical investigators comply with all FDA statutory and regulatory requirements with respect to Products, including : the Federal Food, Drug and Cosmetic Act, as amended (FFDCA), the Public Health Service Act (PHSA), regulatory
  provisions regarding protection of human subjects, financial disclosure by clinical investigators, Institutional Review Boards (IRB), GCP, GLP, IND regulations, and any conditions imposed by a reviewing IRB or the FDA; and (ii) not utilize, in
  conducting studies on Products any person or entities that at such time are debarred by FDA, or that, at such time, are under investigation by FDA for debarment action pursuant to the provisions of the Generic Drug Enforcement Act of 1992 (21 U.S.C.
  Section 335).       

           (e) Commencing upon the Effective Date, NatImmune will use commercially reasonable efforts to assist Enzon in connection with
    Enzon’s response to current and future FDA inquiries about the Products with the goal of enabling Enzon to file an IND as soon as reasonably practicable.   

     3.3 Manufacture and Supply.      

           (a) Manufacturing Development. Enzon shall use Diligent Efforts to develop or have developed a
  suitable formulation of Products for commercial sale worldwide and to develop scale-up and validation procedures for the manufacture of commercial quantities of Products and conduct such other manufacturing development work as is reasonably
  necessary to manufacture and package commercial quantities of Products, including formulation and stability development and process validation.   

           (b) Technology Transfer. In accordance with a technology transfer schedule and 
  procedure that the Parties shall establish within ninety (90) days after the Effective Date, 


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NatImmune shall also promptly provide Enzon with information in its possession relative to 
  the manufacturing, formulation, and packaging of Compounds and Products.       

           (c) Commercial Supply in the Enzon Territory. Enzon shall use Diligent Efforts to manufacture or
  have manufactured the Products for the Development and Commercialization of Products in the Enzon Territory, and shall maintain or arrange for sufficient manufacturing capacity to meet the reasonably anticipated market demand for the Products in the
  Enzon Territory and NatImmune Territory.       

           (d) Enzon Supply to NatImmune. Subject to the negotiation and execution of a mutually agreed
  manufacturing and product supply agreement between Enzon and NatImmune, which shall be completed no later than twelve (12) months from the Effective Date and shall contain the terms set forth in Schedule
    3.3(d), Enzon shall use Diligent Efforts to manufacture or have manufactured and maintain or arrange sufficient manufacturing capacity to supply to NatImmune or NatImmune’s licensee(s), for so long as Enzon
  manufactures or has manufactured the Products for sale in the Enzon Territory, such quantities of Product as required to meet patient demand solely in the NatImmune Territory. If requested by NatImmune, and subject to Enzon’s then-current
  capacity limitations, Enzon shall also supply to NatImmune and its licensees such quantities of Compounds in bulk form as NatImmune or its licensees may order for use in making Topical Products upon commercially reasonable terms substantially
  similar to those set forth in Schedule 3.3(d).  

     3.4 Development Costs.  

           (a) Subject to Section 3.4(d), Enzon shall be responsible for all costs associated with 
  the Development and Commercialization of Products incurred after the Effective Date. For 


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the avoidance of doubt, NatImmune shall be responsible for costs related to services provided 
  by Diosynth B.V. under the Diosynth Agreement through the date of this Agreement.  

           (b) NatImmune agrees to use commercially reasonable efforts in performing the tasks set forth on Schedule 3.4(b) related to the Development of the Products; provided, that NatImmune may cease any such task at any time, if, after exerting such
  commercially reasonable efforts, NatImmune determines in good faith that it is not capable of performing the applicable task. Enzon shall pay NatImmune the payments in the amounts and at the times set forth in such Schedule, plus Enzon shall
  reimburse NatImmune for [**Redacted**]. Enzon shall pay NatImmune the particular amounts specified on Schedule 3.4(b) no later than
  ten 
  (10) Business Days after the occurrence of the event associated with each such amount. 

           (c) If the Parties agree that NatImmune shall perform other activities in connection
  with the Development, the Parties will agree on reasonable compensation to NatImmune for performing such services. If applicable, within thirty (30) days after the end of each Enzon Quarter, NatImmune shall submit to Enzon an
      accounting of all costs NatImmune incurs under the Development Plan during that Enzon Quarter, including reasonable detail demonstrating the specific basis for the costs and expenses included in the summary. Enzon shall on an Enzon Quarterly basis,
  within forty-five (45) days after the end of each Enzon Quarter (provided that NatImmune submitted its accounting report on time), prepare and submit to NatImmune a reimbursement of the costs [**Redacted**].       

           (d) NatImmune shall be responsible for costs related to additional activities specifically required for obtaining Regulatory
  Approvals in the NatImmune Territory, and NatImmune shall be responsible for all costs related to Commercialization of Products in the NatImmune Territory.


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     3.5  Product Trademarks.  Enzon shall select and own Product Trademarks for sale of Product in
  the Enzon Territory. Enzon shall grant NatImmune a royalty free license to use such Product Trademarks solely in the NatImmune Territory solely in connection with the sale in the NatImmune Territory of Products by NatImmune, its Affiliates or
  licensees for as long as NatImmune, its Affiliates or licensee sell Products. NatImmune shall use the Products Trademarks in accordance with sound trademark usage principles and in accordance with all Laws. Enzon shall have the right, which shall be
  exercised in a reasonable manner, to inspect NatImmune’s facilities and records relating to the Products to the extent reasonably required to assure conformance with the foregoing requirements.   

     3.6  Commercialization.      

           (a) Marketing Efforts in the Enzon Territory. Enzon shall use Diligent Efforts to promote,
      market, sell and otherwise Commercialize the Products in the Enzon Territory. Such efforts may include, as appropriate as determined by Enzon in the exercise of its commercially reasonable judgment, the use of product detailing efforts directed to
      potential prescribers of the Product, pre-launch medical education campaigns, pricing and reimbursement activities, medical education activities, Phase IV testing and other sales, marketing and promotion activities customarily used by comparable
      pharmaceutical companies for products of similar market potential.      

           (b) Advertising and Promotion. NatImmune, its Affiliates or licensee may adapt and use the core
  promotional and training materials prepared by Enzon for marketing the Products in the Enzon Territory in connection with the marketing and promotion of the Products in the NatImmune Territory. Enzon shall own the copyright and all related rights in
  all such advertising and promotional and training materials.


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           (c) Commercialization Plans. Enzon shall use Diligent Efforts to prepare marketing plans for
  such Product, such plans shall contain the details contained in the marketing plans regularly prepared by Enzon for its other products and shall include plans related to the pre-launch, launch, promotion and sale of the Product, and the general
  nature of the marketing, promotion and advertising campaigns proposed to be conducted, including the number of detailing representatives, possible Phase IV Trials and medical education activities (the “Commercialization Plans”). Enzon shall provide a copy of all Commercialization Plans to NatImmune as soon as practicable after such plan(s) are completed.       

           (d) Pricing. As between Enzon and NatImmune, Enzon shall be solely responsible for the pricing
    and other terms of sale for Products in the Enzon Territory, and NatImmune shall be solely responsible for the pricing and other terms of sale for Products in the NatImmune Territory.       

           (e) Coordination. Subject to Law, the Parties shall coordinate and exchange information relating
  to the marketing efforts for the Enzon Territory and the NatImmune Territory, including information relating to medical claims regarding the Products, medical conferences,
  publications, product profiling and positioning strategy, (i) Enzon shall allow, or, if applicable, shall use commercially reasonable efforts to have Enzon’s Sublicensee allow, NatImmune’s sales force to participate in sales and
  promotional training relating to the Products to the same extent as Enzon’s (or Enzon’s Sublicensee’s, as applicable) sales force for the EU; and (b) Enzon will cause its training personnel in the United States to train
  NatImmune’s sales trainers so that NatImmune’s sales trainers are able to conduct sales and promotional training relating to the Products; provided that NatImmune will be
  responsible for all travel and other direct costs relating to its sales force’s or trainer’s participation in such 


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activities, and (ii) each Party shall
    provide the other Party’s sales force with access to and use
  of the same promotional materials that such Party’s sales force uses.   

4.   FINANCIAL TERMS 

     4.1  License Fee. Enzon shall pay to NatImmune a license fee of USD ten million
  ($10,000,000.00) within ten (10) Business Days after the Effective Date.  

     4.2  Milestone Payments. 


           (a) Enzon shall pay NatImmune a milestone payment (each, an “Event Milestone
Payment”) in respect of each of the following events (each, an “Event Milestone”) in the particular amounts specified below no later than ten
(10) Business Days after the occurrence of each Event Milestone, except for Event Milestone Payments related to Event Milestones having Net Sales criteria, in which cases payment shall be made sixty (60) days after the end of the Enzon Quarter in
which the Net Sales criterion is met: 

		
	 	Event Milestone   
	 	
Amount ($USD million)   
	 	   	 	 
	 	
(i) [**Redacted**]   	 	
[**Redacted**]   
	 	
(ii) [**Redacted**]   	 	
[**Redacted**]   
	 	
(iii) [**Redacted**]   	 	
[**Redacted**]   
	 	
(iii) [**Redacted**]   	 	
[**Redacted**]   
	 	
(iv) [**Redacted**]   	 	
[**Redacted**]   
	 	
(v) [**Redacted**]   	 	
[**Redacted**]   
	 	
(vi) [**Redacted**]   	 	
[**Redacted**]   
	 	
(vii) [**Redacted**]   	 	
[**Redacted**]   
	 	 	 	 
	“annual” for purposes
      of subsections (v), (vi) and (vii) shall mean Net Sales during any trailing
    period comprising four (4) full Enzon Quarters. 





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          (b) All Event Milestone Payments set forth in this Section 4.2 shall be paid to 
  NatImmune only once regardless of the number of Products developed under this Agreement. 

          (c) If the Event Milestone Payment set forth in Section 4.2(a)(ii) or 4.2(a)(iii) is achieved without triggering the Event
  Milestone Payment(s) in Section 4.2(a)(i) or 4.2(a)(ii), then Enzon shall pay to NatImmune the Event Milestone Payment in Section 4.2(a)(ii) or 4.2(a)(iii) that is achieved, as applicable, and on the date that such Event Milestone Payment is due,
  Enzon shall also pay to NatImmune the previously unpaid Event Milestone Payments in Section 4.2(a)(i) or 4.2(a)(ii), or both of them, as applicable.       

          (d) If the Event Milestone Payments described in Section 4.2(a)(vi) and (vii) above are both reached during the same calendar
    year, then the second such payment shall not be payable until sixty (60) days after the end of such calendar year.  

          (e) In the event that Enzon has given NatImmune any notice of termination of this Agreement under Section 7.2, Enzon shall remain
      liable for the Event Milestone Payments in Sections 4.2(a)(v)-(vii) that would otherwise become due during the notice period set forth in Section 7.1, but shall not be liable for the Event Milestone Payments in Sections 4.2(a)(i)-(iv) that first
accrue after the date of such notice.   

          4.3 Royalty Payments.      

          (a) During the applicable Royalty Term, on a country-by-country and Product-byProduct basis, Enzon shall pay NatImmune royalty
  payments in accordance with the formula set forth below and the following percentages of Net Sales of Native and Pegylated Products in the Enzon Territory:


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Annual Net Sales of   	 	Marginal Royalty Rate   
	
Products (MUSD)   	 	  	 	  
	 	 	Native
    Product  	 	 Pegylated
    Product 
	
[**Redacted**]   	 	
[**Redacted**]   	 	
[**Redacted**]   
	
[**Redacted**]   	 	
[**Redacted**]   	 	
[**Redacted**]   





Royalties shall equal:

          [**Redacted**]  

where,   

A equals the year to date total Net Sales of all Products, up to [**Redacted**] million;   

AA equals the year to date total Net Sales of all Products (applies only if such Net Sales exceeds 
  [**Redacted**] million);  

B equals [**Redacted**] million;   

C equals the percent of total Net Sales of all Products comprised of Net Sales of Native Products; and   

D equals the percent of total Net Sales of all Products comprised of Net Sales of Pegylated Products

          (b)  Notwithstanding the foregoing, for Net Sales based on sales of a Product in the Enzon Territory, any payments owed with
  respect to Net Sales of such Product in a particular country pursuant to this Section 4.3 shall be reduced (x) by [**Redacted**] for any period of time during the Royalty Term during which
  no Valid Claim exists in such country, (y) by [**Redacted**] if during the relevant Enzon Quarter, one or more Generic Products shall be commercially available in such country and shall have
  in the aggregate a [**Redacted**] or more market share of the aggregate sales of Products and Generic Products as measured by 


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[**Redacted**]; and (z) by [**Redacted**] if during the relevant Enzon Quarter, one or more Generic Products shall be commercially
  available in such country and shall have a [**Redacted**] or more market share of the aggregate sales of Products and Generic Products as measured by [**Redacted**]. Market share for purposes of this Section 4.3 shall be based on data provided by IMS, or if such data is not available, such other reliable data source as reasonably determined by Enzon and
  agreed by NatImmune, such agreement not to be unreasonably delayed or withheld. Notwithstanding the foregoing, in no event shall royalty payments required under Section 4.3(a) be reduced by more than [**Redacted**] as a result of the events described in clauses (x), (y) or (z) above occurring.

          (c) For the avoidance of doubt, no royalties shall be due upon the sale or other transfer among Enzon or its Affiliates, but in
    such cases the royalty shall be due and calculated upon Enzon’s or its Affiliate’s Net Sales to the first independent Third Party; and no royalties shall accrue on the disposition of Product (i) without consideration in reasonable
    quantities by Enzon or its Affiliates (x) as samples (promotion or otherwise), or (y) as donations (for example, to non-profit institutions or government agencies for a non-commercial purpose), or (ii) pursuant to “treatment IND”,
    compassionate use, or other patient care programs authorized by any Regulatory Authority, solely to the extent that the consideration, if any, paid to Enzon pursuant to any such program is limited to reimbursement to Enzon of its costs of
    manufacturing and providing the Product.

          (d) Upon expiration of the Royalty Term in any country with respect to any Product, then as of the effective date of such
  expiration on a country-by-country basis, the licenses from NatImmune to Enzon under Section 2.1(a) and (b) shall convert to a fully-paid, non-exclusive, 


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 sublicensable license under the NatImmune Know-How to make, have made, use, import, offer 
  for sale and sell such Product in the Enzon Territory.

     4.4 Third Party Royalties/Fees. With respect to any royalties payable by NatImmune to Third
  Parties based on sales of Products, or other fees payable by NatImmune to such Third Parties, in either case pursuant to license or other agreements in effect as of the Effective Date of this Agreement, NatImmune shall be solely responsible for
  paying all such fees and royalties to the relevant Third Parties.   

     4.5 Calculating of Royalties.

          (a) In calculating the applicable royalty rates in each Enzon Quarter, the weighted average royalty rate shall first be
  calculated based on the cumulative year-to-date aggregate Net Sales for Native Product and for Pegylated Product in the Enzon Territory; 

          (b) Such
  adjusted weighted average royalty rate (the “Average Full Royalty Rate”) shall be applied to the cumulative year-to-date Net Sales in any country in which none of the reductions
  referred to Section 4.3(b) apply; 

          (c) In respect of all other countries, the Average Full Royalty Rate shall then be adjusted for each country after
taking into account the reductions referred to Section 4.3(b) . Such adjusted Average Full Royalty Rate shall then be applied to the cumulative year-to-date Net Sales in such countries for Native Product and Pegylated Product; and

           (d) The aggregate royalties payable in each Enzon Quarter shall be the sum of the amounts payable under paragraphs (b) and (c) above, less the aggregate amount of
  royalties previously paid in respect of such year.   

     4.6 Pending Patent Applications. If a pending patent application that is included 
  within the NatImmune Patents issues in a country after the Royalty Term has already expired 


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in such country, and such issued Patent contains a Valid Claim, then Enzon shall, (a) within 
  sixty (60) days from the issuance of such Patent, pay to NatImmune royalties based on Net Sales in such country from the date of the expiration of the Royalty Term in such country up to and including the date of issuance of such
Patent and (b) continue to make Royalty Payments in such country so long as there is a Valid Claim in such country. This Section 4.6 shall also apply if there has been a reduction in the royalty payments paid to NatImmune pursuant to Section 4.3(b)
and a NatImmune Patent with a Valid Claim later issues (in which case the amount of any related royalty reduction effected pursuant to Section 4.3(b) shall then be paid to NatImmune).

     4.7  Payments and Payment Reports. All royalties due under Section 4.3 shall be paid within
  forty-five (45) days of the end of the relevant Enzon Quarter for which such payments are due. Each royalty payment shall be accompanied by a statement stating the number, description, aggregate gross sales and aggregate Net Sales, by country, of
  each Product sold during the relevant Enzon Quarter and shall also include the currency conversion rate used, and a calculation of the amount of royalty payment due on such Net Sales.

     4.8  Payment Method. All payments due under this Agreement to NatImmune shall be made by bank
  wire transfer in immediately available funds to an account designated by NatImmune. All payments hereunder shall be made in the legal currency of the United States of America.  

     4.9  No Credits or Refunds. All payments to NatImmune hereunder shall be non-creditable and nonrefundable.

     4.10 Taxes. It is understood and agreed between the Parties that any payments made
  under Section 4.1, 4.2, or 4.3 of this Agreement are inclusive of any value-added or similar tax 


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imposed upon such payments. In addition, in the event any of the payments made by Enzon 
  pursuant to Sections 4.1, 4.2, or 4.3 become subject to withholding taxes under the Laws of any jurisdiction, Enzon shall deduct and withhold the amount of such taxes for the account of NatImmune to the extent required by Law,
such amounts payable to NatImmune shall be reduced by the amount of taxes deducted and withheld, and Enzon shall pay the amounts of such taxes to the proper Governmental Authority in a timely manner and promptly transmit to NatImmune an official tax
certificate or other evidence of such tax obligations together with proof of payment from the relevant Governmental Authority of all amounts deducted and withheld sufficient to enable NatImmune to claim such payment of taxes. Any such withholding
taxes required under Law to be paid or withheld shall be an expense of, and borne solely by, NatImmune. Enzon will provide NatImmune with reasonable assistance to enable NatImmune to recover such taxes as permitted by Law.   

          4.11 Sublicenses.

          (a) In the event Enzon enters into a Sublicense Arrangement with a Third Party, Enzon shall have complete discretion to determine
  the financial terms of each such Sublicense Arrangement, subject to Section 4.11(b) 

          (b) With respect to sublicenses granted by Enzon for rights to a Product in any country in the Enzon Territory with the exception
    of the United States, Enzon shall pay NatImmune [**Redacted**] of all cash and other consideration received by Enzon from a Sublicensee, which shall exclude any amounts received by Enzon
    from such Sublicensee as reimbursement of costs or expenses incurred by Enzon in performing [**Redacted**] activities under any such Sublicensee Arrangement, but shall include (i) royalties,
    (ii) lump sum payments, (iii) milestone payments, (iv) equity issued by such Sublicensee, and (v) revenues from sales of 


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Products by Enzon to such Sublicensee (except the portion of such revenues not exceeding 
  [**Redacted**] of Enzon’s [**Redacted**]). All non-cash consideration shall be valued at 
  its fair market value.

          (c) Net Sales of Product by Enzon to Sublicensees shall not be deemed Net Sales of Products to Third Parties for royalty
  computation purposes under Section 4.3 or for calculating Net Sales by Enzon in Section 4.2(a)(v), 4.2(a)(vi) and 4.2(a)(vii).  

          4.12 United States Sublicense Rights.

          (a) In the event Enzon decides to seek to grant a sublicense (including granting a right to promote the sale of a Product
      manufactured by Enzon) for rights to a Product or Products in the United States of America (“U.S. Sublicense”) prior to [**Redacted**], Enzon will first notify NatImmune of such decision, and will simultaneously provide NatImmune with all material information regarding the formulation, stability, safety and efficacy of the Product and its backups, if any; the status
      of discussions with FDA or any Regulatory Authorities directly relating thereto; and relevant patent information (together, the “U.S. Sublicense Notice”), and NatImmune will have
  twenty (20) days from its receipt of the U.S. Sublicense Notice to decide whether it wishes to pursue negotiations with Enzon to enter into a U.S. Sublicense with Enzon.

          (b) If NatImmune declines to enter into negotiations or does not reply to the U.S. Sublicense Notice within such twenty (20) day
  period, Enzon shall be free to enter into a U.S. Sublicense agreement with a Third Party and shall have no further obligations to NatImmune with respect to such U.S. Sublicense.   

          (c) If NatImmune notifies Enzon that it is interested in acquiring such rights within 
  such twenty (20) day period, then for an additional forty (40) day period, Enzon shall conduct 


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 negotiations on an exclusive basis with NatImmune diligently and in good faith to reach a 
  written agreement with NatImmune, provided that neither Party shall be obligated to enter into such written agreement and failure to enter into such written agreement shall not be considered a breach of this Section 4.12. If the
Parties fail to sign a written agreement within such forty (40) day period, Enzon shall be free to enter into a U.S. Sublicense agreement with a Third Party. 

          4.13 Foreign Exchange. Conversion of sales recorded in local currencies to U.S. dollars will be
  performed in a manner consistent with Enzon's normal practices used to prepare its audited financial statements for external reporting purposes, provided that such practices use a widely accepted source of published exchange rates.

          4.14 Blocked Currency. In each country where the local currency is blocked and cannot be removed
    from the country, royalties accrued in that country shall be paid to NatImmune in the country in local currency by deposit in a local bank designated by NatImmune, unless the Parties otherwise agree.

          4.15 Interest. If Enzon fails to make any payment due to NatImmune under this Agreement, then,
      commencing with the date that is thirty (30) days after such payment was due, interest shall accrue on a daily basis at a rate equal to the thirty (30) day U.S. dollar LIBOR rate effective for the date that payment was due as published by
  The Wall Street Journal, + 2%.

          4.16 Records; Audits. Enzon shall keep or cause to be kept such records as are required to
  determine, in a manner consistent with generally accepted accounting principles in the United States, the sums or credits due under this Agreement, including Net Sales. At the request and expense of NatImmune, Enzon shall permit an independent
  certified public 


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 accountant appointed by NatImmune and reasonably acceptable to Enzon, at reasonable times 
  not more than once a year and upon reasonable notice, to examine only those records as may be necessary to determine, with respect to any Year ending not more than five (5) Years prior to such Party's request, the correctness or
      completeness of any royalty report or payment made under this Agreement. Results of any such examination shall be (i) binding on the Parties other than in the case of manifest error, (ii) limited to information relating to the Products, (iii) made
      available to both Parties, and (iv) subject to the confidentiality provisions of Article 6. NatImmune shall bear the full cost of the performance of any such audit, unless such audit discloses a variance of more than five percent (5%) from the
      amount of the original report, royalty or payment calculation, in which case Enzon shall bear the full cost of the performance of such audit. Enzon shall promptly pay to NatImmune the amount of any underpayment of royalties revealed by an
  examination and review. Any overpayment of royalties by Enzon revealed by an examination and review shall be fully-creditable against future royalty payments under Section 4.3.   

5.  INTELLECTUAL PROPERTY

     5.1 Ownership of Technology. Subject to the terms hereof, including the licenses
  and other rights granted hereunder, all Know-How and Inventions shall be owned as follows, with all issues of inventorship determined by United States patent Law: 

     (a) NatImmune shall own the entire right, title and interest in and to all Know-How and Inventions (including all patents and other intellectual property rights relating thereto) made solely by its
  employees and/or Third Parties acting on behalf of NatImmune in the performance of any activities undertaken by it under this Agreement; 


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     (b) Enzon shall own the entire right, title and interest in and to all Know-How and Inventions (including all patents and other
  intellectual property rights thereto) made solely by its employees and/or Third Parties acting on behalf of Enzon in the performance of its activities undertaken by it under this Agreement; 

     (c) The Parties shall jointly own all Joint Inventions (as defined below) and, subject to the rights granted each Party under this Agreement, each Party may make, use, sell, keep, license or assign its
    interest in Joint Inventions and otherwise undertake all activities a sole owner might undertake with respect to such Joint Inventions, without the consent of and without accounting to the other Party. “Joint
      Inventions” means Inventions for which it is determined, in accordance with United States patent Law, that both: (i) one or more employees, consultants or agents of NatImmune or any other persons obligated to
    assign such Invention to NatImmune; and (ii) one or more employees, consultants or agents of Enzon or any other persons obligated to assign such Invention to Enzon, are joint inventors of such Invention; and

      (d) Subject to appropriate confidentiality undertakings, each Party shall notify the other Party promptly after the completion of invention disclosure statements for
      each Invention (or, if any provisional or other patent applications if filed claiming such invention, promptly after such filing), and, to the extent a Party is granted rights hereunder in such Invention, shall provide a copy of the same to the
      other Party.

     5.2  Patent Prosecution and Maintenance. Except as otherwise provided in this Section 5.2, each
  Party shall direct the filing, prosecution (including any interferences, oppositions, reissue proceedings and reexaminations) and maintenance of all Patents covering Inventions conceived solely by such Party.


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     (a) NatImmune shall direct the filing, prosecution (including any interferences, oppositions, reissuance, and re-examinations)
  and maintenance of all NatImmune Patents. NatImmune shall furnish Enzon with copies of all patent applications, correspondences and other communications relating to NatImmune Patents to and from patent offices in the Enzon Territory, provide Enzon a
  reasonable time to offer comments, and take into account any suggestions and input from Enzon.

     (b) NatImmune shall file, prosecute, and maintain NatImmune Patents in at least the countries listed in Schedule 5.2(b), other than with respect to patent applications filed prior to the Effective Date for which NatImmune does not have the right to file such application in, or designate, any additional
  countries, and in additional countries that Enzon shall reasonably request. If NatImmune determines not to file, prosecute, defend or maintain any patent or patent application (including failing to defend any interference or opposition proceedings)
  within the NatImmune Patents in any country, and providing that no other patent applications or patents containing the same claims are then pending or issued in that same country, then NatImmune shall provide Enzon with thirty (30) days prior
  written notice of such determination and Enzon shall have the right and opportunity to file, prosecute, defend and/or maintain such patent or patent application in Enzon’s name, at Enzon’s sole cost and expense, and such patent or patent
  application shall no longer be included in the NatImmune Patents pursuant to this Agreement, provided, that NatImmune will thereafter have a non-exclusive, perpetual, royalty-free license
  under such patent or patent application in order to make, have made, develop, promote, use, import, offer for sale and sell Compounds and Products in the NatImmune Territory, to make and have made Compounds and Products in the Enzon 


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Territory for sale in the NatImmune Territory and to make, have made, develop, promote, use,
  import, offer for sale and sell Topical Products anywhere; 

     (c) Joint Patents. With respect to the prosecution of patent applications claiming Joint
  Inventions (“Joint Patents”), Enzon shall have the right, at its expense, to take such actions as are necessary or appropriate to procure, prosecute and maintain patents with
  respect thereto (including any interferences, oppositions, reissuance, and re-examinations); provided, that all such patent applications and patents shall be owned jointly. Enzon shall
  furnish NatImmune with copies of such Joint Patents and other material correspondence relating to such Joint Inventions to and from the U.S. Patent and Trademark Office and European Patent Office throughout the Enzon Territory and permit NatImmune
  to offer its comments thereon before Enzon makes a submission to such patent office. Enzon will inform NatImmune of the countries in which it intends to file patent applications for Joint Patents. NatImmune shall offer its comments promptly,
  including any request that the patents be filed in additional countries; provided, that Enzon shall determine the appropriate action after considering in good faith any comments or requests
  from NatImmune. If Enzon determines in its sole discretion not to file, prosecute, defend or maintain any patent or patent application (including failing to defend any interference, revocation or opposition proceedings) within the Joint Patents in
  any country, then Enzon shall provide NatImmune with thirty (30) days prior written notice (or such shorter time period that would permit NatImmune a reasonable opportunity to respond in a timely manner) of such determination and NatImmune shall
  have the right and opportunity to file, prosecute, defend and/or maintain such patent or patent application in NatImmune’s name at NatImmune’s sole cost and expense, and, subject to the other terms of this Agreement, Enzon will thereafter
  have a non-exclusive, perpetual, royalty-


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free license under such patent or patent application in order to make, have made, develop, 
  promote, use, import, offer for sale and sell Compounds and Products in the Enzon Territory and to make and have made Compounds and Products in the NatImmune Territory for sale in the Enzon Territory.

     (d) Unless otherwise provided hereunder, Enzon shall reimburse NatImmune for 50% of the costs NatImmune incurs after the
  Effective Date in connection with respect to the filing, prosecution, and maintenance of NatImmune Patents in the countries listed in Schedule 5.2(b) and 100% of such costs in any additional
  countries requested by Enzon under Section 5.2(b) . Within sixty (60) days after the end of each Enzon Quarter, NatImmune shall submit to Enzon an accounting of all costs NatImmune incurs with regard to the filing, maintenance and prosecution of
  NatImmune Patents during that quarter along with Enzon’s share of those costs as calculated pursuant to this Section 5.2 . Enzon shall, within thirty (30) days after receipt of such accounting from NatImmune, prepare and submit to NatImmune a
  reimbursement of such costs incurred by NatImmune.

     (e) Each Party shall cooperate with the other and take all reasonable additional actions and execute such agreements, instruments
    and documents as may be reasonably required to perfect the other's ownership interest in accordance with this Agreement including, the execution of necessary and appropriate instruments of assignment to achieve such joint ownership as set forth in
    Section 5.   

     5.3  Enforcement of Patent Rights.

     (a) Enforcement of NatImmune Patents. In the event that either Party becomes aware of a
  suspected infringement by a Third Party of any NatImmune Patent licensed to Enzon under this Agreement and such potential infringement or claim relates to a Compound 


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or a Product, such Party shall notify the other Party promptly, and following such notification, 
  the Parties shall confer. Enzon shall have the right, but shall not be obligated, to bring an infringement action at its own expense, in its own name and entirely under its own direction and control in the Enzon Territory.
NatImmune, upon request of Enzon, agrees to join in any such litigation at Enzon's expense and to cooperate with Enzon in connection with such litigation.

     (b) If Enzon fails to prosecute any action described in subsections (a), (b) or (c) of this Section 5.3 within 90 days, NatImmune
  shall have the right, at NatImmune's sole expense, to institute any such litigation.

     (c) Recoveries. In the event either Party exercises the rights conferred in this Section 5.3 and
    recovers any damages or other sums in such action, suit or proceeding or in settlement thereof, such damages or other sums recovered shall first be applied to all out-of-pocket costs and expenses incurred by such Party in connection therewith,
    including attorneys fees. If, after such reimbursement, any funds shall remain from such damages or other sums recovered, the amount of any recovery remaining shall then be allocated between the Parties on a pro rata basis taking into consideration
    the relative economic losses suffered by each Party.


     5.4  Defense of Third Party Claims. If a claim is brought by a Third Party alleging patent
  infringement by Enzon or NatImmune with respect to the manufacture, use, sale, offer for sale or importation of a Compound or Product, each Party will give prompt notice to the other Party of such claim. Promptly upon receipt of such notice, the
  Parties shall meet and discuss in good faith if such activity infringes such Third Party's intellectual property rights, and shall take necessary steps on this matter.


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     5.5 License to Third-Party Patents. If one or more patent licenses from other Third Parties are
  required by Enzon or its Affiliates or Sublicensees in order to make, have made, use, offer to sell, sell or import the Current Product (hereinafter “Third Party Patent Licenses”),
  then [**Redacted**] of the consideration [**Redacted**] under such Third Party Patent Licenses by Enzon, its Affiliates or
  Sublicensees for sale of such Product [**Redacted**] shall be creditable against the royalty payments due NatImmune by Enzon with respect to the sale [**Redacted**] of the Product, which Product would, absent such Third Party Patent License, infringe such patent rights of the Third Party [**Redacted**]; provided, that the royalty payment to NatImmune on account of sales [**Redacted**] shall not be reduced, by more
  than [**Redacted**] of the monies otherwise owed to NatImmune; and any amounts not able to be reduced due to the immediately foregoing limitation shall be carried forward to future
  [**Redacted**] for crediting against future royalties in such country. Notwithstanding the foregoing, Enzon may not credit any amount of such payments paid by Enzon to any Third Party in
  connection with licenses to Patents related to Pegylation technology. Enzon will: (a) notify NatImmune of any decision by Enzon to obtain any Third Party Patent License, and will consult with NatImmune regarding the need for and the terms of any
  such Third Party Patent License prior to entering into any such Third Party Patent License, and (b) provide NatImmune with a copy of any such Third Party Patent License promptly after entering into such license. 

     5.6 Hatch-Waxman
      Certification. Each Party shall
      inform the other of any certification regarding  any Patent such Party
      has received pursuant to either 21 U.S.C. §§ 355(b)(2)(A)(iv)
      or (G)(2)(A)(vii)(IV) or its successor provisions or any similar provisions
      in a country in the Enzon Territory other than the United States and shall
       provide the other Party 


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with a copy of such certification within five (5) days after receipt. The initiation and 
  prosecution of any legal action as a result of such certification or any recovery obtained as a 
  result of such legal action shall be as defined in Section 5.3.

     5.7  Patent Term Restoration/Supplemental Protection. The Parties hereto shall cooperate with
  each other in obtaining patent term restoration or supplemental protection certificates or their equivalents in any country in the Enzon Territory or NatImmune Territory where applicable to NatImmune Patents. In the event that elections with respect
  to obtaining such patent term restoration are to be made, Enzon shall have the right to make the election and NatImmune agrees to abide by such election.   

6.  CONFIDENTIALITY

     6.1 Treatment of Confidential Information. The Parties agree that during the
  Term, and for a period of five (5) years after the end of the Term, a Party receiving Confidential Information of the other Party will (a) maintain in confidence such Confidential Information to the same extent such Party
      maintains its own proprietary industrial information of similar kind and value (but at a minimum each Party shall use commercially reasonable efforts), (b) not disclose such Confidential Information to any Third Party without prior consent of the
  other Party, and (c) not use such Confidential Information for any purpose except those permitted by this Agreement.

     6.2 Exceptions. A Party shall not have the obligations set forth in Section 6.1 with respect to
  any portion of such Confidential Information that it can show by adequate documentation: 

     (a) is publicly disclosed by the disclosing Party, either
  before or after it becomes known to the receiving Party; 


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     (b) was known to the receiving Party, without obligation to keep it confidential, prior to when it was received from the
  disclosing Party; 

     (c) is subsequently disclosed to the receiving Party by a Third Party lawfully in possession thereof without obligation to keep it
    confidential;   

     (d) has been published by a Third Party; or 

     (e) has been independently developed by the receiving Party without the aid,
  application or use of Confidential Information.

     6.3 Authorized Disclosure. Notwithstanding Section 6.1, a Party may disclose Confidential
    Information belonging to the other Party to the extent such disclosure is necessary in the following instances:   

     (a) filing or prosecuting Joint Patents, Compounds or Products; 

     (b) Regulatory Filings for Products; 

     (c) prosecuting or defending litigation relating to Compounds or Products; 

     (d) complying with Laws; and

     (e) disclosure, in connection with the performance of this Agreement, to Affiliates,
  licensees, sublicensees, employees, consultants, or agents, each of whom prior to disclosure must be bound by similar obligations of confidentiality and non-use at least equivalent in scope to those set forth in this Article
  6.

     6.4 The Parties acknowledge that the terms of this Agreement shall be treated as Confidential Information of both Parties. Such
  terms may be disclosed by a Party to individuals or entities covered by 6.3(e) above, each of whom prior to disclosure must be bound by similar obligations of confidentiality and non-use at least equivalent in scope to those set forth in this
  Article 6. Disclosure of the terms of this Agreement (but not other 


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 Confidential Information received from the other Party) may also be made, to actual or 
  potential bankers, lenders and investors of the disclosing Party as long as they are subject to terms of confidentiality and non-use at least equivalent in scope to those set forth in this Article 6. If Enzon or NatImmune becomes
aware of a breach or alleged breach by any individual referred to in Section 6.3(a) or 6.4 of such individual’s confidentiality obligations relating to Confidential Information, then the Party that learns of such breach or alleged breach shall
notify the other Party, and the Parties will use commercially reasonable efforts to enforce available remedies in respect of such breach as soon as reasonably practicable under the circumstances.

     6.5 Publicity. The public announcement of the execution of this Agreement is set forth on
  Schedule 6.5 hereto. In addition, (a) Enzon may make a public statement, including in analyst meetings, concerning the progress of the Compound or Products; (b) NatImmune may make a public
  statement, including in analyst meetings, concerning or the progress of the Compound or Products; and (c) each Party may make a public statement, including in analyst meetings, concerning the terms of this Agreement, where, in the case of (b) and
  (c), such statement (i) is required by Law, applicable stock exchange regulation or legal proceedings, as confirmed upon the request of the other Party by an opinion of counsel, for the Party proposing to make such statement; or (ii) was approved by
  the other Party, such approval shall not be unreasonably withheld or delayed. Otherwise, NatImmune will not make any public announcement regarding the terms of or events related to the Agreement without the prior consent of Enzon. In connection with
  any filing ) that is required by Law, applicable stock exchange regulation or legal proceedings (including any SEC filing of this Agreement), the Party required to make such filing shall endeavor to obtain confidential treatment of economic



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 and trade secret information and
    shall seek the other Party’s views concerning the scope of any
  redaction of this Agreement in any such filing.
  In any event, the Parties agree to take all reasonable action to avoid disclosure
  of Confidential Information except as permitted hereunder, and shall cooperate
  with each other with  respect to all such disclosures. The Party that is required
  to or has otherwise decided to make a public statement pursuant to this Section
  6.5 (the “Disclosing Party”) will, where
reasonably practicable under the circumstances, give the other Party sufficient
  advance notice of the text of any proposed statement so that the other Party
  will have the opportunity to comment upon the statement, and such comments
  will be taken  into account in the final statement. If such advance notice
  is not reasonably practicable, then the Disclosing Party will provide the other
  Party with the text of such statement promptly after such statement is made
by the Disclosing Party.  

     6.6  Publications. Neither
  NatImmune nor its employees shall (and NatImmune shall not grant  rights allowing
  its contractors or investigators to) publish or present any information containing
  any Development Data generated by Enzon’s Development activities of any
  Compound or Product without Enzon's prior consent (which may be withheld  in
  its sole and final discretion), except as required under Section 6.3(d). 

7.  TERM
AND TERMINATION

     7.1 Term. This Agreement shall continue until the earlier of (i) expiration of the
  last Royalty Term, and (ii) the effective date of termination pursuant to Section 7.2 or 7.3 (the 
  “Term”).

     7.2 Termination by Enzon. Enzon may terminate the Agreement at any time for any reason upon one
  hundred and twenty (120) days notice; provided, that NatImmune may then accelerate the effective date of termination to any date that is at least thirty (30) days after


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 receiving such notice. After NatImmune’s
    receipt of any such notice from Enzon, NatImmune 
  shall have the right to discuss with Third Parties the opportunity to obtain a license or other right to Develop and Commercialize the Products upon expiration of the relevant notice period. Additionally, Enzon shall cooperate
reasonably with NatImmune to provide to NatImmune any Confidential Information or Know-How Controlled by Enzon relating to the Development and Commercialization of Products that may be useful to enable NatImmune to enter into such discussions with
such Third Parties; provided, that the disclosure of any such Know-How or Confidential Information is subject to written confidentiality agreements between NatImmune and such Third Parties
substantially similar to those provided in this Agreement.

     7.3 Mutual Termination Rights. Either Party may terminate this Agreement if: 

     (a) The other Party is in material breach of this Agreement, and the non-breaching Party delivers notice of such material breach to the other Party describing in detail
  the nature of such breach and its intent to terminate under this Section 7.3. In the event Enzon fails either to pay or to dispute in good faith any amounts alleged to be due and payable to NatImmune hereunder within 30 days after receiving written
  notice of such failure, NatImmune may terminate this Agreement at the end of such 30 day period. In the event that the alleged breach is not for nonpayment, the allegedly breaching Party shall have ninety (90) days from receipt of such notice to
  cure such breach (or, if such default cannot be cured within such ninety (90)-day period, the breaching Party must commence and diligently continue actions to cure such default during such ninety (90)-day period). Any such termination shall become
  effective at the end of such ninety (90)-day period unless the breaching Party has cured any such breach or default prior to the expiration of such ninety (90)-day period (or, if such default is capable of 


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 being cured but cannot be cured within such ninety (90)-day period, the breaching Party has 
  commenced and diligently continued actions to cure such default provided always that, in such instance, such cure must have occurred within one hundred eighty (180) days after notice thereof was provided to the breaching Party by
  the non-breaching Party to remedy such default); or 

     (b) The other Party is generally unable to meet its debts when due, or makes a general assignment
  for the benefit of its creditors, or there shall have been appointed a receiver, trustee or other custodian for such Party for or a substantial part of its assets, or any case or proceeding shall have been commenced or other action taken by or
  against such Party in bankruptcy or seeking the reorganization, liquidation, dissolution or winding-up of such Party or any other relief under any bankruptcy, insolvency, reorganization or other similar act or Law, and any such event shall have
  continued for sixty (60) days undismissed, unstayed, unbonded and undischarged. In such circumstances, the other Party may, upon notice to such Party, terminate this Agreement, such termination to be effective upon such Party's receipt of such
  notice; or 

     (c) If a Party gives notice of termination under this Section 7.3 and the other Party disputes whether such notice was proper, then the issue
  of whether this Agreement has been terminated shall be resolved in accordance with Article 10 and each Party shall continue to perform its obligations hereunder pending the conclusion of such dispute resolution proceeding. If as a result of such
  dispute resolution process it is determined that the notice of termination was proper, then such termination shall be effective immediately. If as a result of such dispute resolution process, it is determined that the notice of termination was
  improper, then no termination shall have occurred and this Agreement shall remain in effect. During the 


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period of any such dispute resolution this Agreement shall remain in effect and each Party
  shall continue to perform its obligations hereunder.   

     7.4 Effect of Termination.  

     (a) Survival.

          (i) The following provisions shall survive any expiration or termination of
  this Agreement: Articles 6, 9, 10, 11 and Sections 2.4, 3.1(f), 4.15, 4.16, 5.1 and 7.4, together with any sections referenced in such surviving provisions or necessary to give them effect.

          (ii) Termination of this Agreement shall not relieve the Parties of any liability that accrued hereunder prior to the effective
  date of such termination. In addition, termination of this Agreement shall not preclude either Party from pursuing all rights and remedies it may have hereunder or at Law or in equity with respect to any breach of this Agreement nor prejudice either
  Party's right to obtain performance of any obligation. The remedies provided in Sections 7.3 and 7.4(b) are not exclusive of other remedies available to a Party in Law or equity.


     (b) Licenses and Other Rights. 

          (i)  Upon termination of this Agreement by Enzon pursuant to Section 7.2
  or by NatImmune pursuant to Section 7.3(a) or 7.3(b), all licenses to Enzon under Section 2.1 shall terminate, and Enzon shall (without charge, other than reimbursement of out-of-pocket expenses and as otherwise provided below):  



          (1) As soon as reasonably practicable
  after such termination, Enzon will upon NatImmune’s request (i) assign to NatImmune all of Enzon’s
  right, title and interest in and to any agreements between Enzon and Third
  Parties that are 




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freely assignable by Enzon, subject to assumption by NatImmune of all 
  obligations accruing thereunder thereafter, and that relate solely to the development or manufacture of any Product (or, if not relating solely to the Product, shall cooperate with NatImmune to otherwise provide the benefit of
such agreement); (ii) grant NatImmune a license to all Product Trademarks, including any registrations and design patents for in connection with all Products and any Internet domain name registrations for such trademarks and slogans, all to the
extent they relate to a Product; and (iii) assign all of Enzon’s right, title and interest in and to any Development Data, Regulatory Filings and Regulatory Approvals for the Products. To the extent that any agreement described in this Section
is not freely assignable by Enzon, then such agreement will not be assigned, and upon the request of NatImmune, Enzon will cooperate in good faith and use Diligent Efforts to allow NatImmune to obtain a license or other right to the extent Enzon has
the right and ability to do so.

       (2) Enzon will, upon NatImmune’s request, transfer to NatImmune or its designee the management and continued performance of any clinical trials for Products ongoing as of the effective date of
    such termination.

       (3) Enzon will, upon NatImmune’s request, if Enzon is then manufacturing a Product in accordance with GMP requirements, (i) transfer the completed manufacturing process for such Product to
    NatImmune or its designee for its use solely to manufacture such Product and subject to all Third Party rights and obligations, cooperate with NatImmune to effect the transition of such manufacturing process, and (ii) supply NatImmune with clinical
    and 



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commercial quantities of such Product for the shorter of (A) the period until 
  NatImmune or its designee has established and validated a manufacturing process for such Product and is approved to manufacture clinical trial and commercial supplies of such Product or (B) [**Redacted**] from the effective date of such termination; provided, that NatImmune will reimburse Enzon for [**Redacted**] with respect to such Product.

      (4) To the extent requested by NatImmune, Enzon agrees to grant and hereby grants to NatImmune, effective upon such termination of this Agreement, (x) a non-exclusive, fully paid-up, worldwide right
  and license, with the right to sublicense, under Enzon Know-how; and (y) a non-exclusive, worldwide right and license, with the right to sublicense, under Enzon Patents, in the case of both (x) and (y), solely for NatImmune to develop, manufacture,
  sell, offer to sale and otherwise Commercialize Products. In consideration of the license described in subparagraph (y) above, NatImmune shall pay to Enzon a royalty equal to [**Redacted**]
  of its Net Sales of the Product until expiration of the last valid claim of an Enzon Patent encompassed by such license, provided, however, if NatImmune terminates the Agreement pursuant to
  Section 7.3, Enzon’s royalties will be capped at the amount of [**Redacted**]; provided, that NatImmune may offset against
  such payment obligations any contract damages that are determined to be due to NatImmune pursuant to Article 10.   

     (5) Enzon will cooperate in any reasonable manner requested by 
  NatImmune to achieve a smooth and expeditious transition of the development, 



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 manufacturing, marketing, and sales of the Products to NatImmune or its 
  licensees.

     (ii) If Enzon is entitled to terminate this Agreement pursuant to Section 7.3(a) and subject to Section 7.3(c), Enzon may elect,
  in lieu of such termination of this Agreement in its entirety, to terminate the licenses granted to NatImmune under Sections 2.2 and 2.3; and the licenses granted to Enzon under Section 2.1 shall continue, subject to the terms and conditions of this
  Agreement, including any obligation to make all payments under Article 4, and Enzon will no longer be required to hold the meetings described in Section 3.1(a), provide copies of changes to the Development Plan as described in Section 3.1(d),
  provide NatImmune with copies of Commercialization Plans as described in Section 3.6(c), or provide assistance with sales force training or access to promotional materials as described in Section 3.6(e) . In such case, Enzon shall remain liable for
  the Event Milestone Payments, royalties and other payments due under Article 4, however, Enzon may offset against such payment obligations any contract damages that are determined to be due to Enzon pursuant to Article 10.   


8.   REPRESENTATIONS AND WARRANTIES

     8.1 General Representations and Warranties. Each Party represents and
  warrants to the other that, as of the date hereof:

     (a) it is duly organized and validly existing under the Laws of its state or country of incorporation, and has full corporate
  power and authority to enter into this Agreement and to carry out the provisions hereof; 


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     (b) it is duly authorized to execute and deliver this Agreement and to perform its obligations hereunder, and the person or
  persons executing this Agreement on its behalf has been duly authorized to do so by all requisite corporate action; 

     (c) this Agreement is legally
    binding upon it and enforceable in accordance with its terms. The execution, delivery and performance of this Agreement by it does not conflict with any agreement, instrument or understanding, oral or written, to which it is a party or by which it
    may be bound, nor violate any material Law of any Governmental Authority having jurisdiction over it; 

     (d) it has not granted, and will not grant during
      the Term of the Agreement, any right to any Third Party that would conflict with the rights granted to the other Party hereunder. It has (or will have at the time performance is due) maintained and will maintain and keep in full force and effect all
      agreements necessary to perform its obligations hereunder; 

     (e) it is aware of no action, suit or inquiry or investigation instituted by any governmental
        agency that questions or threatens the validity of this Agreement; and 

     (f) all necessary consents, approvals and authorizations of all governmental
          authorities and other Persons required to be obtained by such Party to enter into, or perform its obligations under, this Agreement have been obtained.

     8.2 Representations and Warranties of NatImmune. As of the date hereof, NatImmune hereby
  represents and warrants to Enzon as follows: 

     (a) to the best of NatImmune’s knowledge, (i) the issued NatImmune Patents, and any patents issuing
  from applications within the NatImmune Patents that are now pending will be, valid and enforceable; 


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     (b) NatImmune has not received any written notice or claim that NatImmune is infringing any Third Party Patent through activities
  related to Compounds or Products, and to the best of its knowledge, no Third Party is infringing any NatImmune Patent; 

     (c) to the best of its knowledge,
  the manufacture of rhMBL through the manufacturing process to be used by Diosynth B.V. to produce Product for the upcoming Phase Ib trial (as further described in Schedule 1.10a) does not
  infringe any patents of Third Parties, and the use or sale by Enzon for any of the indications listed in Schedule 1.10b of any such Product containing rhMBL would not infringe any patents of
  Third Parties as a result of such Product having been manufactured through the foregoing manufacturing process; 

     (d) NatImmune is the legal and
  beneficial owner of, or has the right to grant to Enzon the rights granted herein to, all NatImmune Technology with respect to the Compounds and Products, and NatImmune has not entered into any agreement granting any right or interest in such
  NatImmune Technology with respect to the Compounds or Products; 

     (e) Schedule 1.39 contains a complete and correct as of
  the date hereof of all Patents Controlled by NatImmune or any of its Affiliates relating to any Compound or any Product that cover rights licensed to Enzon in this Agreement, and indicates whether such patent or patent application is owned by or
  licensed by NatImmune; 

     (f) Except as provided in any of the Third Party Licenses, none of the NatImmune Patents contain claims covering inventions
  developed with funding from the United States government or any other governmental entity; and 

     (g) NatImmune has disclosed to Enzon all material
  information generated by or for NatImmune concerning the safety and efficacy of the Compounds. 


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     8.3  Licenses. NatImmune covenants and agrees with Enzon that NatImmune: (a) shall not execute or
  otherwise permit, and shall cause its Affiliates to refrain from executing or otherwise permitting, any amendment, modification or waiver to any of the Third Party Licenses without the prior written consent of Enzon, (b) shall not make any election
  or exercise any right or option (or omit to take any action which would), and shall cause its Affiliates to refrain from making any election or exercising any right or option (or omitting to take any action which would), terminate or relinquish in
  whole or in part any Third Party License, (c) shall comply, and shall cause its Affiliates to comply, with all of its or its Affiliates’ obligations under the Licenses in all material respects, (d) shall take, and shall cause its Affiliates to
  take, such actions as shall be necessary to keep in full force and effect the Licenses; and (e) shall use reasonable efforts to give prompt notice to Enzon, together with a review of outstanding issues if Enzon so requests and subject to any
  obligations of confidentiality owed by NatImmune or its Affiliates to the other party to such Third Party License(s), of any actual or alleged defaults, breaches, violations, proposed amendments or proposed modifications of, or any proposed waivers
  under, any of the Third Party Licenses by any of the parties to the Licenses.

     8.4  Disclaimer Concerning Technology. EACH PARTY EXPRESSLY DISCLAIMS ANY AND ALL WARRANTIES OF
  ANY KIND, EXPRESS OR IMPLIED, EXCEPT FOR THOSE SET FORTH IN THIS AGREEMENT, INCLUDING THE WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE, NONINFRINGEMENT OF THE INTELLECTUAL PROPERTY RIGHTS OF THIRD PARTIES OR ARISING FROM A
  COURSE OF DEALING, USAGE OR TRADE PRACTICES, IN ALL CASES WITH RESPECT THERETO. NOTWITHSTANDING 


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ANYTHING TO THE CONTRARY IN THIS AGREEMENT, (A) BOTH PARTIES 
  ACKNOWLEDGE AND AGREE THAT, NOTWITHSTANDING THE DILIGENT EFFORTS OF THE PARTIES, THE ACTIVITIES TO BE CONDUCTED UNDER THE RESEARCH PROGRAM AND ANY DEVELOPMENT PLAN PREPARED BY ENZON ARE INHERENTLY UNCERTAIN, AND THAT THERE ARE NO
  ASSURANCES THAT THE PARTIES WILL SUCCESSFULLY IDENTIFY A DRUG CANDIDATE OR THAT ANY SUCH CANDIDATE WILL BE SUCCESSFULLY DEVELOPED AND COMMERCIALIZED BY ENZON AS A PRODUCT; AND (B) EACH PARTY 
  EXPRESSLY DISCLAIMS ANY REPRESENTATIONS OR WARRANTIES, EXPRESS OR
  IMPLIED, TO THE CONTRARY.   

9.  INDEMNITIES 

     9.1 Mutual Indemnification. Subject to Section 9.3, each Party hereby agrees to
  indemnify, defend and hold the other Party, its Affiliates, its licensees, its licensors, and its and their officers, directors, employees, consultants, contractors, sublicensees and agents (and, in case of such licensors, their
    trustees, faculty, medical and professional staff and students) (collectively, “Representatives”) harmless from and against any and all damages or other amounts payable to a Third
    Party claimant, as well as any reasonable attorneys' fees and costs of litigation arising out of any such Claim (as defined in this Section 9.l), (collectively, “Damages”)
    resulting from claims, suits, proceedings or causes of action (“Claims”) brought by a Third Party against a Party or its Representatives based on: (a) breach of any representation
  or warranty by the Indemnifying Party contained in this Agreement, (b) breach of any applicable Law by such Indemnifying Party, or (c) gross negligence or willful 


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misconduct by such indemnifying Party, its Affiliates, or their respective employees, 
  contractors or agents.  

     9.2  Indemnification
      by a Party.

     (a) Subject
      to Section 9.3, Enzon hereby agrees to indemnify, defend and hold NatImmune,
      its licensors and their Representatives  harmless from and against any
      Damages resulting from Claims brought by a Third Party against NatImmune
      or its Representatives resulting directly or indirectly from Enzon's Development
      or Commercialization of any Product by Enzon, its Affiliates or  Sublicensees,
      including claims by a Third Party alleging patent infringement with respect
      to the manufacture, use, sale, offer for sale or importation of a Compound
      or Product, except to the extent that such Damages are covered by NatImmune's
      indemnification of Enzon pursuant to Section 9.1.

     (b) Subject
       to Section 9.3, NatImmune hereby agrees to indemnify, defend and hold
       Enzon and its Representatives harmless from and  against any Damages resulting
       from Claims brought by a Third Party against Enzon or its Representatives
       resulting directly or indirectly from NatImmune's Development or Commercialization
       of any Topical Product or any Product, rights to which have  reverted
       from Enzon back to NatImmune after termination of this Agreement, except
       to the extent that such Damages are covered by Enzon's indemnification
      of NatImmune pursuant to Section 9.1.

     9.3 Conditions
  to Indemnification. In the event
    that any Third Party asserts a claim with  respect to any matter for which
    a Party (the “Indemnified Party”) is entitled to indemnification
    hereunder (a “Third Party
      Claim”), then the Indemnified Party shall promptly notify the
    Party obligated to indemnify the Indemnified Party (the “Indemnifying
      Party”)
    thereof; provided, however, that no delay on the part of the Indemnified
    Party in 


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notifying the Indemnifying Party shall relieve the Indemnifying Party from any obligation 
  hereunder unless (and then only to the extent that) the Indemnifying Party is prejudiced 
  thereby.

     (a) The Indemnifying Party shall have the right, exercisable by notice to the Indemnified Party within ten (10) Business Days of
  receipt of notice from the Indemnified Party of the commencement of or assertion of any Third Party Claim, to assume direction and control of the defense, litigation, settlement, appeal or other disposition of the Third Party Claim (including the
  right to settle the claim solely for monetary consideration) with counsel selected by the Indemnifying Party and reasonably acceptable to the Indemnified Party; provided, that the
  Indemnifying Party shall seek the prior consent of any such Indemnified Party as to any settlement that would materially diminish or materially adversely affect the scope, exclusivity or duration of any Patents licensed under this Agreement, would
  require any payment by such Indemnified Party, would require an admission of legal wrongdoing in any way on the part of an Indemnified Party or would effect an amendment of this Agreement. In the case of any Third Party Claim that is the subject of
  Section 9.3, Enzon shall be entitled to control the defense of such Third Party Claim subject to the remaining provisions of this Section 9.3.

     (b) Within ten (10) days after the Indemnifying Party has given notice to the Indemnified Party of its intended exercise of its
  right to defend a Third Party Claim, the Indemnifying Party shall be entitled, at its sole cost and expense, to assume and conduct such defense, with counsel selected by the Indemnifying Party. During such time as the Indemnifying Party is
  controlling the defense of such Third Party Claim, the Indemnified Party shall cooperate, and cause its Affiliates and agents to cooperate upon request of the 


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Indemnifying
  Party in the defense or prosecution of the Third Party Claim, including by 
  furnishing such records, information and testimony
and attending such conferences, discovery proceedings, hearings, trials or appeals
as may reasonably be requested by the Indemnifying Party. In the event that the
Indemnifying  Party does not notify the Indemnified Party of the Indemnifying
Party's intent to defend any Third Party Claim within ten (10) Business Days
after notice thereof, the Indemnified Party may (without further notice to the
Indemnifying Party) undertake  the defense thereof with counsel of its choice
and at the Indemnifying Party's reasonable expense (including reasonable, out-of-pocket
attorneys' fees and costs and expenses of enforcement or defense). The Indemnifying
Party or the Indemnified  Party, as the case may be, shall have the right to
join in (including the right to conduct discovery, interview and examine witnesses
and participate in all settlement conferences), but not control, at its own expense,
the defense of any Third Party  Claim that the other Party is defending as provided
in this Agreement.

     (c) In
  no event may an Indemnified Party settle or compromise any Third Party Claim
  for which it/he/she intends to seek  indemnification from the Indemnifying Party
  hereunder without the prior consent of the Indemnifying Party, or the indemnification
  provided under such Section 9.1, 9.2 or 9.3 as to such Third Party Claim shall
  be null and void. 

10. DISPUTE
  RESOLUTION 

     10.1  Disputes. The Parties recognize that disputes as to certain matters may from
  time to time arise during the Term that relate to either Party's rights and/or obligations hereunder. It is the objective of the Parties to facilitate the resolution of disputes arising under this Agreement in an expedient manner
  by mutual cooperation and without resort to legal proceedings. To accomplish this objective, the Parties agree that, in the event of any disputes,


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controversies or differences that may arise between the Parties, out of or in relation to or in 
  connection with this Agreement, or for the breach thereof, upon the request of either Party, the Parties agree to meet and discuss in good faith a possible resolution thereof. If the matter is not resolved within sixty (60) days
following the request for discussions, either Party may commence an action in accordance with Section 10.2 below. Notwithstanding the foregoing, each Party shall be entitled to seek injunctive relief and specific performance in any court or arbitral
tribunal without waiting for the expiration of any such sixty (60) day period.

     10.2 Governing Law; Arbitration. Resolution of all disputes arising out of or related to this
  Agreement or the performance, enforcement, breach or termination of this Agreement and any remedies relating thereto, shall be governed by and construed under the substantive Laws of the State of New York, without regard to conflicts of law rules
  that would provide for application of the Law of a jurisdiction outside New York. If such controversy or claim cannot be resolved by means of negotiations as described in Section 10.1, then such controversy or claim shall be resolved by binding
  arbitration as provided below. The arbitration shall be conducted in English. The award of arbitration shall be final and binding upon both Parties. Any arbitration proceeding shall be conducted in accordance with the Arbitration Rules of the London
  Court of International Arbitration (“LCIA”). The place of arbitration shall be London, England. The Parties hereby irrevocably and unconditionally submit to the jurisdiction of the
  LCIA for the purposes of the arbitration proceedings, and any counterclaims that relate in any respect to the Agreement. The arbitration shall be conducted by a panel of three persons. Within 30 days after initiation of arbitration, each Party shall
  select one person to act as arbitrator and the two Party-selected arbitrators shall select a third arbitrator within 30 days of their appointment, which third arbitrator must be experienced in 


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the pharmaceutical business. If the arbitrators selected by the Parties are unable or fail to 
  agree upon the third arbitrator, the third arbitrator shall be appointed by the LCIA. The procedures specified in this Section 10.2 shall be the sole and exclusive procedures for the resolution of disputes between the Parties
      arising out of or relating to this Agreement; provided, that a Party, without prejudice to the above procedures, may seek injunctive relief or other provisional judicial relief if in its sole judgment such action is necessary to avoid irreparable
      damage, and further provided that any disputes regarding the scope, patentability, inventorship, validity or enforceability of any Patent shall be submitted for resolution by a court of competent jurisdiction in the country in which such Patent was
  filed or issued. Despite such action the Parties will continue to participate in good faith in the procedures specified in this Section 10.2.   

11. MISCELLANEOUS 

     11.1  Limitation on Damages. IN NO EVENT SHALL EITHER PARTY OR
  THEIR AFFILIATES BE LIABLE FOR PUNITIVE, INDIRECT, INCIDENTAL OR CONSEQUENTIAL DAMAGES, WHETHER BASED ON CONTRACT, TORT OR ANY OTHER LEGAL THEORY AND IRRESPECTIVE OF WHETHER SUCH PARTY HAS BEEN ADVISED OF THE POSSIBILITY OF ANY
    SUCH LOSS OR DAMAGE; PROVIDED, THAT THIS LIMITATION SHALL NOT LIMIT THE INDEMNIFICATION OBLIGATION OF SUCH PARTY UNDER THE PROVISIONS OF ARTICLE 9 FOR SUCH DAMAGES CLAIMED BY A THIRD PARTY
    AND NOTHING IN THIS SECTION 11.1 IS INTENDED TO LIMIT ENZON’S PAYMENT OBLIGATIONS UNDER ARTICLE 4. Without limiting the foregoing, the Parties agree that NatImmune shall be entitled in any arbitration proceeding under this Agreement to seek to
  recover costs and expenses that 


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NatImmune actually incurs in performing certain Development activities if the arbitrators 
  determine that Enzon has breached its obligation to perform such activities.

     11.2 Entire Agreement; Amendment. This Agreement, including the exhibits attached hereto, sets
  forth the complete, final and exclusive agreement and all the covenants, promises, agreements, warranties, representations, conditions and understandings between the Parties hereto and supersedes and terminates all prior agreements and
  understandings between the Parties. There are no covenants, promises, agreements, warranties, representations, conditions or understandings, either oral or written, between the Parties other than as are set forth herein and therein. No subsequent
  alteration, amendment, change or addition to this Agreement shall be binding upon the Parties unless reduced to writing and signed by an authorized officer of each Party.

     11.3 Force Majeure. Both Parties shall be excused from the performance of their obligations
  under this Agreement to the extent that such performance is prevented by force majeure and the nonperforming Party promptly provides notice of the prevention to the other Party. Such excuse shall be continued so long as the condition constituting
  force majeure continues and the nonperforming Party takes reasonable efforts to remove the condition. For purposes of this Agreement, force majeure shall include conditions beyond the control of the Parties, including , an act of God, voluntary or
  involuntary compliance with any regulation, Law or order of any government, war, terrorism, civil commotion, labor strike or lock-out, epidemic, failure or default of public utilities or common carriers, destruction of production facilities or
  materials by fire, earthquake, storm or like catastrophe; provided, however, the payment of invoices due and owing hereunder shall not be delayed by the payer because of a 


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force majeure affecting the payer, unless such force majeure specifically precludes the 
  payment process.

     11.4  Notices. Any
    notices, approvals, or consents required or permitted to be given
  under this Agreement shall be in writing, shall
  specifically refer to this Agreement and shall be deemed to have been sufficiently
  given for all purposes if mailed by first class certified or registered mail,
  postage prepaid,  internationally recognized express delivery service or personally
  delivered. Unless otherwise specified in writing, the mailing addresses of
  the Parties shall be as described below:

	
	
For NatImmune:   	
NatImmune A/S   
	 	Fruebjergvej 3, box 3 
	 	DK-2100 Copenhagen 
	 	Denmark  
	   	 
	 	Attention: Chief Executive Officer  
	   	 
	
With a copy to:   	
Wiggin and Dana LLP   
	 	400 Atlantic Street  
	 	P.O. Box 11032  
	 	Stamford, CT 06911-0325  
	 	Facsimile +1 203 363 7676  
	 	Attention: James Farrington, Esq.  
	   	 
	
For Enzon:   	
Enzon Pharmaceuticals, Inc.   
	 	685 Rt. 202/206  
	 	Bridgewater, NJ 08807 
	 	Attention: Vice President, Business Development  
	 	With a copy to: Vice President and General
    Counsel  





     11.5   United States Dollars. References in this Agreement to “Dollars” or “$” shall
mean the legal tender of the United States of America.

     11.6   No Strict Construction. This Agreement has been prepared jointly and shall
  not be strictly construed against either Party.


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     11.7  Assignment.

     (a) If NatImmune commences an insolvency proceeding under the Danish Bankruptcy Act and to the extent legally permissible, prior
  to entering into discussions with any Third Party with respect to the sale or other divestment of the NatImmune Technology and its rights under this Agreement (collectively, the “MBL Assets”), NatImmune will notify Enzon (the “Divestment Notice”). Enzon will have twenty (20) days from its receipt of the Divestment Notice to decide whether it wishes to
  pursue negotiations with NatImmune to acquire the MBL Assets.

     (b) If Enzon declines to enter into negotiations or does not reply to the Divestment Notice within such twenty (20) day period,
    NatImmune shall be free to so divest the MBL Assets to a Third Party and shall have no further obligations to Enzon with respect thereto.

     (c) If Enzon notifies NatImmune that it is interested in acquiring the MBL Assets within such twenty (20) day period, then for an
      additional forty (40) day period, NatImmune shall conduct negotiations on an exclusive basis with Enzon diligently and in good faith to reach a written agreement with Enzon, provided that neither Party shall be obligated to enter into such written
      agreement and failure to enter into such written agreement shall not be considered a breach of this Section 11.7. If the Parties fail to sign a written agreement within such forty (40) day period, NatImmune shall be free to divest the MBL Assets to
      a Third Party.

     (d) Within
    30 days after the Effective Date, the Chief Executive Officers of the Parties
    shall meet in person (or via telephone if mutually agreed upon by the Parties)
    in order to discuss (i) possible terms pursuant to which Enzon could have
    a right to negotiate rights under certain other circumstances where NatImmune
  decides to divest the MBL Assets; or (ii) such 


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other matters that either Party wishes to discuss including matters concerning the MBL Assets 
  or potential future business transactions between Enzon and NatImmune.

     11.8   Counterparts. This Agreement may be executed in two or more counterparts, each of which
  shall be deemed an original, but all of which together shall constitute one and the same instrument.

     11.9   Further Actions. Each Party agrees to execute, acknowledge and deliver such further
    instruments, and to do all such other acts, as may be necessary or appropriate in order to carry out the purposes and intent of this Agreement.

     11.10   Severability. If anyone or more of the provisions of this Agreement is held to be invalid
      or unenforceable by any court of competent jurisdiction from which no appeal can be or is taken, the provision shall be considered severed from this Agreement and shall not serve to invalidate any remaining provisions hereof. The Parties shall make
      a good faith effort to replace any invalid or unenforceable provision with a valid and enforceable one such that the objectives contemplated by the Parties when entering into this Agreement may be realized.

     11.11    Interpretation. The paragraph and other headings contained in this Agreement are for
  reference purposes only and shall not affect the meaning or interpretation of this Agreement. All references in this Agreement to an Article, Section or Schedule shall refer to an Article, Section or Schedule in or to this Agreement, unless
  otherwise stated. Any reference to any federal, national, state, local, or foreign statute or Law shall be deemed also to refer to all rules and regulations promulgated thereunder, unless the context requires otherwise. The word
  “including” and similar words mean “including without limitation.” The words “herein,” “hereof” and “hereunder” and other words of similar import refer to this Agreement as a whole and not to any
  particular Article, Section or other subdivision. References in this Agreement to 


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 “provisions of this Agreement” refer to the terms, conditions and promises contained in this 
  Agreement taken as a whole. All references to months, quarters or years/annual are references to calendar months, calendar quarters, or calendar years, respectively, unless otherwise specified. References to the singular include
the plural.

     11.12    No Waiver. Any delay in enforcing a Party's rights under this Agreement or any waiver as
  to a particular default or other matter shall not constitute a waiver of such Party's rights to the future enforcement of its rights under this Agreement, excepting only as to an express written and signed waiver as to a particular matter for a
  particular period of time.

IN WITNESS WHEREOF, the Parties have executed this Agreement in duplicate originals by their proper officers as of the date and year first above written.  

	 	NATIMMUNE A/S	 	 	ENZON PHARMACEUTICALS, INC.
	 	 	 	 	 
	 	 	 	 	 
	BY:	/S/
    Martin Bonde 	 	BY:	/S/ Jeffrey H. Buchalter
	 	 	 	 	 
	NAME:	Martin Bonde  	 	NAME:	Jeffrey H. Buchalter
	 	 	 	 	 
	TITLE: 	Chief Executive Officer  	 	TITLE:	 Chairman, President and Chief Executive
    Officer
	 	 	 	 	 
	 	 	 	 	 
	 	 	 	 	 
	BY:	/S/ Claus Berner Møller 	 	 	 
	 	 	 	 	 
	NAME:	Claus Berner Møller  	 	 	 
	 	 	 	 	 
	TITLE: 	Chairman  	 	 	 







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EXECUTION PAGE TO NATIMMUNE-ENZON LICENSE AGREEMENT 


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SCHEDULE
  1.10a  

PROCESS DESCRIPTION  

The manufacturing process referred to in Sections
  1.10 and 8.2(c) is generally described in the following Diosynth Research Instructions
  that were provided to Enzon prior to the Effective Date:   

          [**Redacted**] 


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SCHEDULE
  1.10b  

          • [**Redacted**]


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SCHEDULE 1.39


NATIMMUNE PATENTS


	 	Patent
          title

      (key words)	  	Ownership-

Inventor	  	Pat.
    no’s	  	Priority	  	USA	  	Europe

      (all major

      countries	  	Canada	  	Japan	  	Australia	  	Rest
          of 

World
	 	Isolation of lectins (617) 

      

      MBL isolation using affinity 

      resin	 	Owned

    Inventor: Finn

    Matthiesen	 	China: 02824319.6

    Europe: 02782779.9

    India: 1091/CHENP/2004

    Japan: 2003-536261

    USA: 10/398,151	 	19-10-2001  	 	pending  	 	Notice
    of intention

    to
    grant

    Expiry
    date: 18-10-2022	 	No application
      filed	 	pending  	 	No application 

    filed	 	China pending
        

    India pending
	 	Pharmaceutical

compositions
          comprising 

mannose binding lectin (625) 



MBL in high conc. without

albumin



Stabilization by Calcium	 	Owned

Inventors: Jesper Lund

Larsen and 

Leif Kongerslev	 	China: 03810580.2

Europe: 03388016.2-1216

India: 2297/CHENP/2004

Japan: 2003-575990

USA: 10/388,322	 	15-03-2002   	 	pending  	 	pending  	 	No application 

    filed	 	pending  	 	No application 

    filed	 	China pending
        

    India pending 
	 	Collectin-complement

activating protein chimeras (703)



Chimeric molecules of MBL 

and Ficolin  	 	Owned

Inventors:
Leif Kongerslev, 

Dietmar Weilguny, Finn 

Matthiesen	 	China:
          03825026.8

          Europe: 03794818.9

          India:

    559/CHENP/2005

    Japan: 2004-535018

    USA: 10/527,191	 	10-09-2002  	 	pending  	 	pending  	 	No application 

    filed	 	pending  	 	No application 

    filed	 	China pending
        

    India pending
	 	Production of high

molecular mass lectins

(578)

          

          Method of preparation

          (MBL precipitation)	 	Owned

Inventor: Finn

Matthiesen	 	China: 02817175.6

      Europe: 02762272.9

India: 00284/DELNP/2004

India-divisional:

00284/DELNP/2004

Japan: 2003-515547

USA: 10/484,501	 	23-07-2001  	 	pending  	 	pending  	 	No application 

    filed	 	pending  	 	No application 

    filed	 	China pending
        

    India Notice 

        of
        Acceptance

Expiry date: 

23-07-2022
	 	Mannan-binding lectin

(MBL) treatment of

infections in individuals

treated with TNF-alfa

inhibitors (477)



Subset of RA patients on

therapy developing sepsis	 	Owned

Inventor: Per Fischer	 	Europe: 01956425.1

USA: 10/332,712	 	13-07-2000  	 	pending  	 	pending  	 	No application 

    filed	 	pending  	 	No application 

    filed	 	No application 

    filed





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Treatment of SARS in   	  	
Jointly owned. 90%   	  	
PCT:   	  	
09-04-   	  	
pending   	  	
Not yet nationalized   	  	
Not yet   	  	
Not yet   	  	
Not yet   	  	
Not yet   
	 	
individuals (774)   	 	
NatImmune 10%   	 	
PCT/DK2004/000266   	 	
2003   	 	   	 	   	 	
nationalized   	 	
nationalized   	 	
nationalized   	 	
nationalized   
	 	   	 	
University of Aarhus   	 	
USA: 10/820,155   	 	
10-05-   	 	   	 	   	 	   	 	   	 	   	 	   
	 	
Prevention and treatment by   	  	
Also present in list of   	  	   	  	
2003   	  	   	  	   	  	   	  	   	  	   	  	   
	 	
MBL   	 	
licensed patents   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   
	 	   	  	
Inventors: Leif   	  	   	  	   	  	   	  	   	  	   	  	   	  	   	  	   
	 	   	 	
Kongerslev, Dietmar   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   
	 	   	  	
Weilguny, Finn   	  	   	  	   	  	   	  	   	  	   	  	   	  	   	  	   
	 	   	 	
Matthiesen, Jens   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   
	 	   	 	
Christian Jensenius   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   
	 	
Novel cancer indications of   	 	
Owned   	 	
Denmark: PA 2005   	 	
11-04-   	 	No  	 	
Priority founding   	 	No  	 	No  	 	No  	 	No  
	 	mannan-binding lectin  	 	Inventor: Martin  	 	00508  	 	2005  	 	application  	 	application  	 	application  	 	application  	 	application  	 	application
	 	(MBL) in the treatment of  	  	Bonde  	  	 	  	 	  	filed  	  	 	  	filed  	  	filed  	  	filed  	  	filed  
	 	immuno-compromised  	 	 	 	   	 	   	 	 	 	   	 	 	 	 	 	 	 	   
	 	individuals (1018)  	  	   	  	   	  	   	  	 	  	   	  	 	  	 	  	 	  	 
	 	 	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   
	 	Prevention and treatment by  	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 	  	 
	 	MBL 	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   
	 	 	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   
	 	
Human Mannose Binding   	  	
Licensed   	  	
US 5,270,199   	  	
20-08-   	  	
Patent   	  	
Patent issued   	  	No  	  	No  	  	No  	  	No  
	 	
Protein (001)   	 	
From Childrens   	 	   	 	
1987   	 	
issued   	 	
EP 0375736   	 	application  	 	application  	 	application  	 	application  
	 	   	  	
Hospital Corporation   	  	   	  	   	  	
US   	  	
Expiry date: 5-8-   	  	filed  	  	filed  	  	filed  	  	filed  
	 	
Composition of Matter   	 	   	 	   	 	   	 	
5,270,199   	 	
2008   	 	 	 	 	 	 	 	 
	 	   	  	   	  	   	  	   	  	
Expiry   	  	
(United Kingdom,   	  	   	  	   	  	   	  	   
	 	   	 	   	 	   	 	   	 	
date:   	 	
Germany, France   	 	   	 	   	 	   	 	   
	 	   	 	   	 	   	 	   	 	
14-12-2010   	 	
and Switzerland)   	 	   	 	   	 	   	 	   
	 	
Novel indications of   	 	
Licensed:   	 	
Canada: 2,372,128   	 	
14-05-   	 	
Patent   	 	
Patent issued   	 	
Pending   	 	
Pending   	 	
Patent   	 	
New   
	 	
mannan-binding lectin   	  	
Inventors: Steffen Thiel   	  	
China: 00809714.3   	  	
1999   	  	
issued   	  	
EP 1181038   	  	   	  	   	  	
issued   	  	
Zealand   
	 	
(MBL) in the treatment of   	 	
and Jens Christian   	 	
China-divisional: not   	 	   	 	
US   	 	
Expiry date: 10-05-   	 	   	 	   	 	
AU 779404   	 	
Patent issued   
	 	
immunocompromised   	  	
Jensenius   	  	
yet filed   	  	   	  	
6,562,784   	  	
2020   	  	   	  	   	  	   	  	
NZ 515718   
	 	
individuals (456)   	 	   	 	
Europe-Divisional:   	 	   	 	
Expiry   	 	
(United Kingdom,   	 	   	 	   	 	   	 	   
	 	   	  	   	  	
03029993.7   	  	   	  	
date:   	  	
Germany, France   	  	   	  	   	  	   	  	   
	 	
Immunodeficiency   	  	   	  	
Japan: 2000-618310   	  	   	  	
10-05-2020   	  	
and Switzerland   	  	   	  	   	  	   	  	   
	 	
treatment with MBL   	 	   	 	
Norway: 20015481   	 	   	 	   	 	
and also Austria,   	 	   	 	   	 	   	 	   
	 	   	  	   	  	
Russia: 2001133345   	  	   	  	   	  	
Belgium, Spain,   	  	   	  	   	  	   	  	   
	 	   	 	   	 	
Russia-Divisional:   	 	   	 	   	 	
Finland, Italy,   	 	   	 	   	 	   	 	   
	 	   	  	   	  	
2005125625   	  	   	  	   	  	
Holland, Portugal,   	  	   	  	   	  	   	  	   
	 	   	 	   	 	
USA continuation:   	 	   	 	   	 	
Denmark and   	 	   	 	   	 	   	 	   
	 	   	 	   	 	
10/424,769   	 	   	 	   	 	
Sweden)   	 	   	 	   	 	   	 	   
	 	
Purification process for   	 	
Cross Licensed from   	 	
PCT/DK99/00319   	 	
10-6-1998   	 	
Patent   	 	
Notice of intention   	 	
Pending   	 	
Pending   	 	
Pending   	 	
China   
	 	
production of Mannan-   	  	
Danish State Serum   	  	   	  	   	  	
issued   	  	
to grant   	  	   	  	   	  	   	  	
pending   
	 	
binding lectin and an MBL   	 	
Institute   	 	
WO99/64453   	 	   	 	
US   	 	
Expiry date: 10-6-   	 	   	 	   	 	   	 	
Russia   
	 	
medicinal product   	  	   	  	   	  	   	  	
6,429,192   	  	
2019   	  	   	  	   	  	   	  	
pending   
	 	   	 	   	 	
US19980101007P   	 	   	 	
Expiry   	 	   	 	   	 	   	 	   	 	
Norway   
	 	
Plasma process with general   	  	   	  	   	  	   	  	
date: 10-6-   	  	   	  	   	  	   	  	   	  	
pending   
	 	
product claims   	 	   	 	   	 	   	 	
2019   	 	   	 	   	 	   	 	   	 	
New   
	 	   	  	   	  	   	  	   	  	   	  	   	  	   	  	   	  	   	  	
Zealand   
	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	
pending   






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Recombinant Human   	  	
Licensed   	  	
PCT/DK00/00246   	  	
14-05-   	  	
Patent   	  	
pending   	  	
pending   	  	
pending   	  	
pending   	  	
New   
	 	
Mannan Binding Lectin   	 	
From Jensenius & Thiel   	 	   	 	
1999   	 	
Issued US   	 	   	 	   	 	   	 	   	 	
Zealand   
	 	
(433)   	 	   	 	
WO00/70043   	 	   	 	
6,846,649   	 	   	 	   	 	   	 	   	 	
Patent   
	 	   	  	   	  	   	  	   	  	
Expiry   	  	   	  	   	  	   	  	   	  	
issued   
	 	
Method of preparation   	 	   	 	
US09/568,143   	 	   	 	
date: 10-5-   	 	   	 	   	 	   	 	   	 	
No. 515717   
	 	   	 	   	 	   	 	   	 	
2020   	 	   	 	   	 	   	 	   	 	
Expiry date:   
	 	   	  	   	  	   	  	   	  	   	  	   	  	   	  	   	  	   	  	
10-5-2020   
	 	   	  	   	  	   	  	   	  	
(Divisional   	  	   	  	   	  	   	  	   	  	
China   
	 	   	 	   	 	   	 	   	 	
pending)   	 	   	 	   	 	   	 	   	 	
pending   
	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	
Russia   
	 	   	  	   	  	   	  	   	  	   	  	   	  	   	  	   	  	   	  	
pending   
	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	
Norway   
	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	
pending   
	 	
Method for curing   	  	
Licensed from   	  	
PCT/BE2003/000158   	  	No  	  	
pending   	  	
pending   	  	No  	  	
pending   	  	No  	  	
China   
	 	critically ill patients
    (1034)  	 	K.U. Leuven
    Research  	 	   	 	application  	 	   	 	   	 	application  	 	   	 	application  	 	pending  
	 	 	 	& Development  	 	   	 	filed  	 	   	 	   	 	filed  	 	   	 	filed  	 	India  
	 	SIRS prevention  	 	   	 	   	 	 	 	   	 	   	 	 	 	   	 	 	 	pending  
	 	   	  	University of
    Aarhus  	  	   	  	   	  	   	  	   	  	   	  	   	  	   	  	 
	 	   	 	Aarhus  	 	   	 	 	 	   	 	   	 	 	 	   	 	 	 	   
	 	 	 	 Kommunehospital  	 	   	 	   	 	   	 	   	 	   	 	   	 	   	 	 
	 	
Human Mannose Binding   	  	
Licensed   	  	
US 5,270,199   	  	
20-08-   	  	
Patent   	  	
Patent issued   	  	No  	  	No  	  	No  	  	No  
	 	
Protein (001)   	 	
From Childrens   	 	   	 	
1987   	 	
issued   	 	
EP 0375736   	 	application  	 	application  	 	application	 	application  
	 	   	 	
Hospital Corporation   	 	   	 	   	 	
US   	 	
Expiry date: 5-8-   	 	filed  	 	filed  	 	filed  	 	filed  
	 	
Composition of Matter   	  	   	  	   	  	   	  	
5,270,199   	  	
2008   	  	 	  	 	  	 	  	 
	 	   	 	   	 	   	 	   	 	
Expiry   	 	
(United Kingdom,   	 	   	 	   	 	   	 	   
	 	   	 	   	 	   	 	   	 	
date:   	 	
Germany, France   	 	   	 	   	 	   	 	   
	 	   	 	   	 	   	 	   	 	
14-12-2010   	 	
and Switzerland)   	 	   	 	   	 	   	 	   






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SCHEDULE 1.61


THIRD PARTY LICENSES



						
	  	Agreement   	 	 	
    Licensor(s)   	 	 	
    Date   	 
	 	
    Exclusive License   	  	
    Children’s Medical   	  	
    June 6, 2001   
	 	
    Agreement   	 	
    Center   	 	
    (amended September   
	 	  	 	  	 	
    8, 2001)   
	 	
    Exclusive License   	  	
    Jens Chr. Jensenius   	  	
    April 27, 2000   
	 	
    Agreement   	 	
    and Anders Sjöholm   	 	
    (amended May 27,   
	 	  	 	  	 	
    2000 and February 12,   
	 	  	 	  	 	
    2001)   
	 	
    Exclusive License   	  	
    Jens Chr. Jensenius   	  	
    April 27, 2000   
	 	
    Agreement   	 	
    and Steffen Thiel   	 	
    (amended August 31,   
	 	  	 	  	 	
    2000 and January 25,   
	 	  	 	  	 	
    2001)   
	 	
    Exclusive License   	  	
    Jens Chr. Jensenius,   	  	
    April 27, 2000   
	 	
    Agreement   	 	
    Steffen Thiel and   	 	
    (amended August 31,   
	 	  	 	
    Thomas Vorup Jensen   	 	
    2000 and January 2,   
	 	  	 	  	 	
    2001)   
	 	
    Cross Patent License   	 	
    Statens Serum Institut   	 	
    January 13, 2005   
	 	
    Agreement   	 	  	 	  
	 	
    Exclusive License   	  	
    County of Aarhus,   	  	
    June 6, 2005   
	 	
    Agreement   	 	
    University of Aarhus,   	 	  
	 	  	  	
    Department of   	  	  
	 	  	 	
    Surgery and   	 	  
	 	  	  	
    Anaesthesiology   	  	  
	 	  	 	
    (Intensive Care   	 	  
	 	  	  	
    Section) of the   	  	  
	 	  	  	
    Katholieke   	  	  
	 	  	 	
    Universiteit Leuven   	 	  





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SCHEDULE 3.3(d) 


PRODUCT SUPPLY TERMS

		
	 	 
	Product Supply  	Enzon will supply all of
    NatImmune’s requirements necessary to
meet patient demand for the Products in the NatImmune
Territory, which, subject to regulatory requirements, will be
manufactured by the same process, in the same formulation(s)
and conform to the same product specifications as the Product
sold by Enzon in other countries in the European Union in the
Enzon Territory.   
	   
	 	 
	Failure to
    Supply  	Enzon will use commercially
    reasonable efforts to maintain
sufficient manufacturing capacity to meet the worldwide
forecasted demand for such Products (by NatImmune, Enzon,
and their Affiliates and Sublicensees). In the event that Enzon
becomes unable to supply the worldwide quantities of Products
ordered or forecasted by NatImmune and Enzon (including,
Affiliates and Sublicensees), then available Product shall be
allocated to NatImmune in the NatImmune Territory in the same
proportion as available Product is allocated to Enzon (and its
Affiliates and Sublicensees) in the Enzon Territory.   
	   
	Term  	For so long as Enzon manufactures
    for itself, subject to the
termination provisions set forth in the supply agreement.   
	   
	 	 
	Purchase Price  	The purchase price for the
    Product (the “Product Purchase
Price”) will be an amount equal to [**Redacted**].   
	   
	 	 
	Payments  	Enzon will submit invoices
    upon each shipment. NatImmune
will pay all invoices, plus all proper taxes, freight and other
transportation charges stated thereon, within 45 days after its
receipt.   
	   
	 	 
	Forecasts  	The Parties will establish
    reasonable forecast procedures that take
into account necessary lead time for manufacture and market
demand for the Product.   
	   
	 	 
	Delivery  	All Product will be delivered
    FCA (INCOTERMS 2000) at the
place of manufacture.   
	   
	 	 
	Quality  	All Product will be manufactured
    in accordance with cGMP and
applicable product specifications. The Product will be released
in accordance with all applicable regulatory requirements and
mutually acceptable product release specifications. A Certificate
of Analysis will accompany each batch of Product. If   





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NatImmune provides prompt written notice that any Product does
not conform to any such requirements, Enzon will, at
NatImmune’s option, replace the non-conforming Product or
refund the applicable Product Purchase Price. An independent
testing laboratory will resolve all disputes regarding the quality
of the Product.   
	   
	Recalls  	If the Product should be
    recalled, the Parties will take all
appropriate corrective actions. Enzon will be responsible for all
recall costs to the extent resulting from a breach of the foregoing
warranties and the product supply agreement. The Parties will
fully cooperate and provide all reasonable assistance in
conducting any recall.   
	   
	Labels  	All Product will be shipped
    in final package form with all
applicable packaging labels, including all package inserts.   
	   
	[**Redacted**]	
[**Redacted**]





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SCHEDULE 3.4(b)



TECHNOLOGY TRANSFER TASKS AND PAYMENTS





[**Redacted**]


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SCHEDULE 5.2(b)

NATIMMUNE PATENT COUNTRIES      

Albania 

Australia 

Belarus

 Brazil 

Bulgaria

Canada 

China/Hong Kong 

Croatia 

European
  Union 

Iceland 

India

 Israel 

Japan 

Liechtenstein
  

Mexico 

New Zealand 

Norway 

Romania
  

Russian Federation 

Serbia/Montenegro
  

Singapore 


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South Africa

  

  South Korea 

  

  Switzerland 

  

  Taiwan 

  

  Turkey 

  

  Ukraine 

  

  United States


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      SCHEDULE 6.5 

PRESS
  RELEASE 

		




 For Immediate Release








	
	
PRESS RELEASE   	   
	   
	
Contacts Enzon Pharmaceuticals, Inc.:   	
Contacts NatImmune A/S:   
	   
	
Craig Tooman   	
Martin Bonde   
	
EVP, Finance and Chief Financial Officer   	
Chief Executive Officer   
	
908-541-8759   	
+45 39 17 94 44  
	   
	
Susan M. Mesco   	   
	
Director, Investor Relations   	   
	
908-541-8777   	   





ENZON ACQUIRES GLOBAL RIGHTS FROM NATIMMUNE FOR ONCOLOGY PRODUCT

Bridgewater, NJ and Copenhagen, Denmark – September ___, 2005 – Enzon Pharmaceuticals, Inc. (Nasdaq: ENZN) and the Danish biotech company, NatImmune A/S today announced that they have entered into a license agreement for
  NatImmune’s lead development product, recombinant human Mannan-Binding Lectin (rhMBL), a protein therapeutic being developed for the prevention of severe infections in MBL-deficient individuals undergoing chemotherapy. Under the agreement,
  Enzon receives exclusive worldwide rights, excluding the Nordic countries, and is responsible for the development, manufacture, and marketing of rhMBL. NatImmune will receive an upfront payment of $ 10
  million and is eligible to receive additional payments upon the successful
  completion of certain clinical development, regulatory, and sales-based milestones.
  NatImmune is also eligible to receive royalties from any future product sales
  of rhMBL by Enzon and retains certain rights to develop a non-systemic formulation
  for topical administration of MBL.


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Mannan-Binding Lectin (MBL) is a naturally occurring human plasma protein that plays a key role in the immune system’s first-line defense against infections. MBL binds to a wide range of invading organisms, including
  bacteria, fungi, viruses, and parasites and activates the lectin pathway of the complement system, an important defense mechanism of the immune system.  

Numerous studies have found a strong correlation between MBL-deficiency and an increased susceptibility to infections in patients with a suppressed immune system, such as cancer patients undergoing treatment with chemotherapy. In
  addition, a number of publications have also highlighted the potentially important future role of MBL replacement therapy in preventing serious infections in other critical care areas associated with immunodeficiency.  

“Today’s announcement underscores our commitment to rebuilding our clinical pipeline with promising product development opportunities,” said Jeffrey H. Buchalter, Enzon’s chairman and chief executive officer.
  “Given the vital role MBL plays in the immune system, this compound represents an exciting opportunity for us to bring a substantial clinical advantage to patients who are susceptible to serious infections.”


  “We believe Enzon’s extensive experience in developing and commercializing therapeutics for patients with cancer and other immunodeficiency disorders makes them an ideal partner to advance this high-potential
    therapeutic,” said Dr. Martin Bonde NatImmune’s chief executive officer.  “Further, we will also work together to leverage Enzon’s long-standing skills in developing optimized versions of protein-based therapeutics through
  PEGylation to potentially explore a next-generation compound.”  

In December 2004, NatImmune completed Phase 1 clinical trials that evaluated the safety and pharmacokinetic profile of single and multi dose intravenous administration of rhMBL in 28 MBL-deficient volunteers.  Results from the
  Phase 1 trials demonstrated that rhMBL replacement therapy is safe and has an attractive pharmacokinetic profile. NatImmune has also completed a prospective correlation study of 250 hematological cancer patients that documented MBL-deficient
  patients have a significantly higher risk of severe infections following chemotherapy compared to patients with sufficient MBL levels.  These results confirmed previous clinical correlation studies published in the Lancet in August 2001.

About Enzon  

Enzon Pharmaceuticals, Inc. is a biopharmaceutical company dedicated to the development and commercialization of therapeutics to treat patients with cancer and other life-threatening diseases. Enzon’s specialized sales force
  markets ABELCET®, ONCASPAR®, ADAGEN®, and
  DEPOCYT® in North America.  In addition, Enzon also receives royalties on sales of PEG-INTRON®, marketed by
  Schering-Plough Corporation, and MACUGEN®, marketed by Eyetech Pharmaceuticals and Pfizer Inc.  Enzon’s product-driven strategy includes an extensive drug development program
  that leverages its proprietary technologies, including a next-generation PEGylation platform that utilizes linkers designed to release compounds at a controlled rate. Enzon complements its internal research and development efforts with strategic
  initiatives, such as partnerships designed to broaden its revenue base or provide access to promising new


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technologies or product development opportunities. Further information about Enzon and this press release can be found on the Company’s web site at www.enzon.com.

About NatImmune  

NatImmune A/S is a biotech company focused on the development of therapeutic proteins. Based in Symbion Science Park, the Company was founded in 2000 and has 22 employees. NatImmune’s lead product, Mannan
  Binding Lectin (MBL),  has completed Phase 1 clinical trials and is being developed under a global licensing agreement with the U.S. biopharmaceutical company, Enzon Pharmaceuticals, Inc. NatImmune has retained certain rights to develop a
  non-systemic formulation for the topical administration of MBL.  In addition, the Company’s pipeline also includes antibodies for the treatment of colorectal cancer (COU-I) and cardiovascular diseases (MASP-2). Further information about
  NatImmune can be found at the Company’s web site at www.natimmune.com.   

There are forward-looking statements contained
      herein that are not based on historical fact, including without limitation
      statements containing the words “believes,” “may,” “plans,”
  “will,” “estimate,” “continue,” “anticipates,” “intends,” “expects,” and similar expressions. Such forward-looking statements involve known and unknown risks, uncertainties and other
  factors that may cause actual results, events or developments to be materially different from the future results, events or developments discussed above. Such factors include, but are not limited to the timing of, success, and cost of clinical
  studies; the ability to obtain regulatory approval of products; and those described in Enzon’s Form 10-K and Forms 10-Q on file with the United States Securities and Exchange Commission and NatImmune’s
  publicly filed reports. These factors should be considered carefully and readers
  are cautioned not to place undue reliance on such forward-looking statements.
  All information in this press release is as of September ____, 2005 and Enzon
  and NatImmune undertake no duty to update this information.

# # #


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