SAT Report

PMN Number: P-13-0078

SAT Date: 11/9/2012

Print Date: 1/7/2013

Related cases:

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 2-3 2

 Persistence Bioaccum Toxicity Comments

1 12

Exposure Based Review:

Health: Yes

Ecotox: No

Routes of exposure: Health: Dermal Drinking Water Inhalation 

Ecotox: All releases to water

Fate: ;

Keywords:

 Keywords: ACUTE, IRR-S,E, KIDNEY, LIVER, REPRO-M, ADRENAL, 

DEVEL

Summary of Assessment:

 Fate:

Fate Summary: P-13-0078

FATE: 

Liquid with MP < 20 C (E)

log Kow = -1.12 (E) 

S > 10 g/L at 25 C (E)

VP = 4.2E-4 torr at 25 C (NOMO5)

BP = 317 C (M)

H < 1.00E-8 (E)

log Koc = 1.38 (E)
log Fish BCF = 0.50 (E)

log Fish BAF = -0.05 (E) 

POTW removal (%) = 0-25 via biodeg; OECD 301F(Mano Resp): 1-3%/28d 

 NRB.

Time for complete ultimate aerobic biodeg = wk-mo

Sorption to soils/sediments = low

PBT Potential: P1B1

*CEB FATE: Migration to ground water = rapid

 Health:

 Health Summary: Absorption is poor through the skin based on 

physical/chemical properties and good through the lungs and GI tract based on analogs. There is 

concern for moderate acute toxicity, irritation/corrosion to all exposed tissues, kidney toxicity, 

liver toxicity, effects to the adrenals, and reproductive toxicity to males based on test data for an 

analog Moderate high concern. 

 Test Data: TEST DATA for analog, 

negative in Salmonella with and without activation

negative in mouse micronucleus assay, ip

negative in a rat hepatocyte unscheduled DNA synthesis assay

acute oral study in rats - deaths at 400 mg/kg and greater; no deaths at 320 mg/kg; LD50 = 573 

mg/kg in females; signs of stomach irritation in animals that died; decreased activity, salivation, 

diarrhea, ptosis, poor grooming, piloerection, abnormal stance, abnormal gait, dyspnea, 

prostration

acute dermal study in rabbits - LD50 = 750 mg/kg, necrosis of the skin at the site of application

not a dermal sensitizer in guinea pigs

corrosive to the eye in rabbits

corrosive to the skin in rabbits

dermal developmental toxicity study in rabbits (0.1 ml applied of a 1, 5, or10% concentration- no 

deaths; decrease in maternal body weight gain at 10% concentration; severe skin irritation at 5 

and 10% concentration; increase in kidney weights at 10% concentration; histopathological 

changes in the kidneys at 5 and 10% concentration; increase in liver weights in all dose groups; 

decrease in litter weights and female fetal weights at 10% concentration

acute inhalation study in rats (2.204 mg/L) - LC50 > 2.204 mg/L; 1 animal sacrificed in 

moribund condition and Day 5; signs of irritation

Test DATA for same analog submitted with 

rat acute oral LD50 = 677 mg/kg;

rabbit acute dermal LD50 = 0.25 to 0.63 mL/kg;

rat acute inhalation LC100 = 200 ppm, LC0 = 68 ppm, with toxic signs to lungs and eyes;

rat acute inhalation LC20 = 149 ppm;

rat acute inhalation LC50 = 166 ppm calculated from several tests;

rat 6-h acute inhalation LC50 = 117 ppm with possible neurotoxic signs 

rat skin irritation test: moderate irritation in 3 min, severe irritation and corrosion in 60 min 

human skin irritation 
negative skin sensitization in guinea pigs at 4% induction, 2% 1st challenge, and 1% 

re-challenge 

moderate eye irritation in rabbits at 5% ai and higher, no irritation at 1% ai;

rabbit eye irritation test via exposure to vapor for 2 h: 10 ppm = severe eye irritation, 1 ppm = 

no significant irritation;

rat 7-d oral toxicity test via diet NOEL = 0.15 mg/kg/d, LOEL = 0.22 mg/kg/d based on reduced 

body weight and kidney toxicity, at 0.33 mg/kg/d = liver toxicity, reduced body weight, and 

kidney toxicity;

rat 9-d dermal toxicity test via 1 mL for 6 h/d at 10% ai, 5% ai, and 2.5% ai: LOEL = 2.5% ai 

based on irritation at site of application and kidney toxicity, at 5% ai = decreased body weight, 

irritation and necrosis at site of application, and kidney toxicity, and at 10% ai = necrosis at site 

and kidney toxicity 

rat 9-d inhalation at 90 ppm, 40 ppm, and 20 ppm with LC100 at 90 ppm and 40 ppm, and 

irritation to all exposed tissues at all doses;

rat 9-d inhalation at 20 ppm, 10 ppm, and 1 ppm with NOEC = 1 ppm, LOEC = 10 ppm based on

irritation, at 20 ppm irritation and blood toxicity ;

rat 9-d inhalation test showed death at 47 ppm

rat 14-wk=90-d inhalation toxicity test at 5.8 ppm, 1.25 ppm, and 0.220 ppm for 5 d/wk NOEC = 

1.25 ppm, LOEC = 5.8 ppm based on reduced body weight, and effects to the adrenals and 

testes;

rabbit 90-d dermal toxicity test at 1 mL of 2% ai, 0.7% ai, and 0.2% ai for 5 d/wk = 20 mg/kg/d, 

7.5 mg/kg/d, and 2.5 mg/kg/d showed moderate skin irritation at all doses, no systemic toxicity 

rat dermal developmental toxicity test at 10%ai, 5%ai, and 1%ai showed fetal LOEL = 10%ai, 

fetal NOEL = 5%ai, maternal NOEL = 1%ai, and maternal LOEL = 5%ai based on severe skin 

irritation;

Ames test was negative;

CHO forward gene mutation test negative;

mouse micronucleus test via ip was negative 

rat hepatocyte unscheduled DNA synthesis was negative;

SCE with CHO cells was negative;

mouse in vivo peripheral micronucleus test negative;

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 >100

daphnid 48-h LC50 >100

green algal 96-h EC50 >100 23

fish _ chronic value >10

daphnid _ chronic 

value

>10

algal _ chronic 

value

>10 5.7
Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for ; SAR 

chemical class = ; MW 261; liquid; log Kow = -0.42 (EPI); S > 1000 g/L at 25 

C (P); pH7; effective concentrations based on 100% active ingredients and mean measured 

concentrations; hardness < 150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

570

SARs

SAR Class

Ecotox Category 

Ecotox Factors Comments: 

 SAT Chair: Becky Jones