<PAGE>
                                                                  Exhibit 10.25 

                             EMPLOYMENT AGREEMENT
                             --------------------


     Amended and Restated Employment Agreement, dated the 1st day of March,
1999 by and between Brian J. Smith (the "Employee") and Boron, LePore &
Associates, Inc., a Delaware corporation (the "Company").  In consideration of
the mutual promises and covenants herein contained, the parties hereto agree as
follows:

     1.   Employment.
          ---------- 

          Subject to the provisions of Section 6, the Company hereby employs the
Employee and the Employee accepts such employment upon the terms and conditions
hereinafter set forth.

     2.   Term of Employment.
          ------------------ 

          Subject to the provisions of Section 6, the term of the Employee's
employment pursuant to this Agreement shall commence on and as of the date
hereof (the "Effective Date") and shall terminate on the second anniversary of
the Effective Date; provided, however, that the term of the Employee's
employment pursuant to this Agreement shall be extended automatically for
successive one-year periods ending on the relevant anniversary of the Effective
Date unless either party gives the other notice no later than 270 days prior to
the scheduled termination date (i.e., the second anniversary of the Effective
Date or any later anniversary) of his or its determination not to extend the
term of the Employee's employment pursuant to this Agreement, whereupon such
term of employment shall terminate as of such anniversary date; and provided
further, however, that in the event a Change of Control (as defined in Section
10 hereof) shall occur, then (subject to Sections 6 and 10) such term of
employment shall not expire by reason of non-extension by the Company pursuant
to this Section 2 prior to the date which is 18 months following such Change of
Control.  The period during which the Employee serves as an employee of the
Company in accordance with and subject to the provisions of this Agreement is
referred to in this Agreement as the "Term of Employment."

     3.   Duties.
          ------ 

          During the Term of Employment, the Employee (a) shall serve as an
employee of the Company with the title of Corporate Executive Vice President,
reporting to the Chief Executive Officer of the Company, and shall perform such
duties and have such responsibilities and shall have such additional or
alternative duties as may be reasonably determined by the Chief Executive
Officer of the Company, consistent with the general area of the Employee's
experience and skills; (b) upon the request of the Chief Executive Officer of
the Company, shall serve as an officer and/or director of the Company's
subsidiaries; and (c) shall render all services reasonably incident to the
foregoing.  The Employee hereby accepts such employment, agrees to serve the
Company in the capacities indicated, and agrees to use his best efforts in, and
shall devote his full working time, attention, skill and energies to, the
<PAGE>
 
advancement of the interests of the Company and its subsidiaries and the
performance of his duties and responsibilities hereunder.

     4.   Salary and Bonus.
          ---------------- 

          (a)  During the Term of Employment, the Company shall pay the Employee
a salary at the annual rate of $225,000 per annum (the "Base Salary").  Such
Base Salary shall be subject to withholding under applicable law, shall be pro
rated for partial years and shall be payable in periodic installments not less
frequently than monthly in accordance with the Company's usual practice for
executives of the Company as in effect from time to time.  The Board of
Directors or Compensation Committee of the Company shall review the Base Salary
of the Employee at least annually, but such salary shall not be set at a rate
lower than $225,000 per annum.

          (b)  Bonus.  During the Term of Employment, the Employee shall be
               -----                                                       
entitled to participate in such executive bonus program as may be established by
the Company and then in effect, subject to and in accordance with the terms
thereof.

     5.   Benefits.
          -------- 

          (a)  During the Term of Employment, the Employee shall be entitled to
participate in any and all medical, pension, dental and life insurance plans,
disability income plans, stock incentive plans, retirement arrangements and
other employment benefits as in effect from time to time for executive officers
of the Company generally.  Such participation shall be subject to (i) the terms
of the applicable plan documents (including, as applicable, provisions granting
discretion to the Board of Directors of the Company or any administrative or
other committee provided for therein or contemplated thereby); and (ii)
generally applicable policies of the Company.

          (b)  Notwithstanding the foregoing, during the Term of Employment the
Company shall provide the Employee with or reimburse the Employee for a Company
automobile and club dues in accordance with the Company's practices for
executive officers, as in effect from time to time.

          (c)  The Company shall promptly reimburse the Employee for all
reasonable business expenses incurred by the Employee during the Term of
Employment in accordance with the Company's practices for executive officers of
the Company with a similar level of responsibility, as in effect from time to
time.

          (d)  During the Term of Employment, the Employee shall receive paid
vacation annually in accordance with the Company's practices for executive
officers, as in effect from time to time, but in any event not less than four
(4) weeks per calendar year.

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<PAGE>
 
          (e)  The Company will purchase on behalf of the Employee a term life
insurance policy providing a death benefit of $1,000,000 in the event of the
Employee's death and naming such person or persons as the Employee may designate
as loss payee or payees. The obligation to purchase and the maintenance of such
life insurance policy during the Term of Employment, however, shall be
contingent upon (i) the Employee's satisfactory completion of all requirements
in connection therewith including, without limitation, a physical examination,
and (ii) the annual premium payments for such policy not exceeding $5,000;
provided, however, that if such amount is not adequate to cover a policy with a
--------  -------                                                              
death benefit of $1,000,000, the Company shall purchase a term life insurance
policy providing for the maximum death benefit payable for an annual premium of
$5,000.

          (f)  Compliance with the provisions of Section 4(b) or Section 5 shall
in no way create or be deemed to create any obligation, express or implied, on
the part of the Company or any of its affiliates with respect to the
continuation of any particular benefit or other plan or arrangement maintained
by them or their subsidiaries as of or prior to the date hereof or the creation
and maintenance of any particular benefit or other plan or arrangement at any
time after the date hereof, except as provided in Sections 5(b), 5(c), 5(d) and
5(e).

     6.   Termination of Employment of the Employee.
          ----------------------------------------- 

          Prior to the expiration of the Term of Employment as provided in
Section 2 hereof, this Agreement may or shall (as applicable) be terminated as
follows:

          (a)  At any time by the mutual consent of the Employee and the
     Company.

          (b)  At any time for "cause" by the Company upon written notice to the
     Employee.  For purposes of this Agreement, a termination shall be for
     "cause" if:

               (i)   the Employee shall commit an act of fraud, embezzlement,
          misappropriation or breach of fiduciary duty against the Company or
          any of its subsidiaries, or shall be convicted by a court of competent
          jurisdiction of, or shall plead guilty or nolo contendere to, any
          felony or any crime involving moral turpitude; or

               (ii)  the Employee shall commit a breach of any of the covenants,
          terms or provisions hereof, which breach has not been remedied within
          thirty (30) days after delivery to the Employee by the Company of
          written notice of the facts constituting the breach; or

               (iii) the Employee shall have failed to comply with written
          instructions from the Company's Chief Executive Officer, which are
          reasonable and consistent with Section 3, or shall have substantially
          failed to perform the Employee's duties hereunder for a period of
          thirty (30) days after written notice from the Company.

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<PAGE>
 
          Upon termination for cause as provided in this Section 6(b), (A) all
     obligations of the Company under this Agreement shall thereupon immediately
     terminate other than any obligation of the Company with respect to earned
     but unpaid Base Salary and benefits contemplated hereby to the extent then
     accrued or vested, it being understood that upon any such termination the
     Employee shall not be entitled to (1) receive any bonus or portion thereof
     from the Company or any of its affiliates not then paid whether pursuant to
     Section 4 or otherwise, or (2) any continuation of benefits except as may
     be required by law, and (B) the Company shall have any and all rights and
     remedies under this Agreement and applicable law; provided, however, that
     termination of this Agreement by the Employee for Good Reason (as defined
     in Section 10) within 18 months following a Change of Control shall not be
     deemed grounds for termination pursuant to this Section 6(b).

          (c)  Upon the death of the Employee or upon the permanent disability
     (as defined below) of the Employee continuing for a period in excess of one
     hundred eighty (180) consecutive days.  Upon any such termination of the
     Employee's employment as provided in this Section 6(c), all obligations of
     the Company under this Agreement shall thereupon immediately terminate
     other than (i) any obligation of the Company with respect to earned but
     unpaid Base Salary and benefits contemplated hereby to the extent accrued
     or vested through the date of termination and (ii) the obligation of the
     Company to pay the Employee or his estate cash bonuses earned as of the
     date of termination.  As used herein, the terms "permanent disability" or
     "permanently disabled" shall mean the inability of the Employee, by reason
     of injury, illness or other similar cause, to perform a major part of his
     duties and responsibilities in connection with the conduct of the business
     and affairs of the Company, as determined reasonably and in good faith by
     the Company.

          (d)  By the Employee on at least 60 days' prior written notice to the
     Company.  Upon termination by the Employee as provided in this Section
     6(d), all obligations of the Company under this Agreement thereupon
     immediately shall terminate other than any obligation of the Company with
     respect to earned but unpaid Base Salary and benefits contemplated hereby
     to the extent accrued or vested through the date of termination, it being
     understood that in the event of such a termination the Employee shall not
     be entitled to (i) receive any bonus from the Company or any of its
     affiliates not then paid whether pursuant to Section 4 or otherwise with
     respect to any period during or after the Term of Employment or (ii) any
     continuation of benefits except to the extent required by law.

          (e)  At any time without "cause" (as defined in Section 6(b)) by the
     Company upon written notice to the Employee.  In the event of termination
     of the Employee by the Company pursuant to this Section 6(e), the Company
     shall continue to make Base Salary payments to the Employee in the manner
     contemplated by Section 4(a) from the date of termination through the first
     anniversary of the date on which such termination occurs, and the Company
     shall also remain obligated to pay the full amount of the 

                                       4
<PAGE>
 
     target bonus contemplated by Section 4(b) for the year in which such
     termination occurs, when and as it otherwise would have paid such bonuses;
     subject, however, to the provisions of Section 10 in the event any such
     termination occurs within 18 months following any Change of Control.
     Notwithstanding the foregoing, if the Employee's employment terminates
     pursuant to Section 6(e) or 6(f) in the 18 months following a Change of
     Control and at the time of such termination no target bonus shall be in
     effect or such target bonus shall be lower than the average of the
     Employee's bonus for the two most recent years, than in such circumstances
     the bonus payment of the Employee's severance which is otherwise payable
     pursuant to this Agreement shall equal the average bonus and shall be paid
     promptly following such termination. Such payments of bonus and Base Salary
     amounts contemplated by Section 6(e) or 6(f) are agreed by the parties
     hereto to be in full satisfaction, compromise and release of any claims
     arising out of the Employee's employment or termination thereof pursuant to
     this Section 6(e) or Section 6(f). In any case the payment of all such
     amounts under Sections 6(e) or 6(f) shall be contingent upon the Employee's
     compliance with Section 8 below and the Employee's delivery of a general
     release upon termination of employment covering all matters arising under
     or connection with this Agreement. Such release shall be in a form
     reasonably satisfactory to the Company, it being understood that no
     severance benefits shall be provided unless and until the Employee
     determines to execute and deliver such release.

          (f)  The Employee shall have the right to terminate his employment
     hereunder (i) in the event of a material default by the Company in the
     performance of its obligations hereunder, after the Employee has given
     written notice to the Company specifying such default by the Company and
     giving the Company a reasonable time, not less than 30 days, to conform its
     performance to its obligations hereunder or (ii) without limitation of
     clause (i), for Good Reason during the 18 months following any Change of
     Control as contemplated by Section 10.  The rights and obligations of the
     parties shall be as set forth in Section 6(e) and Section 10, as
     applicable, in the event of any such termination.

          (g)  In the event either party gives a notice of non-renewal to be
     effective as of any anniversary hereof as contemplated by Section 2, then
     all obligations of the parties hereunder shall terminate as of the end of
     the Term of Employment except as contemplated by Sections 7, 8, 9, 11, 12,
     13 and 14 hereof.

     7.   Confidentiality; Proprietary Rights.
          ----------------------------------- 

          (a)  In the course of performing services hereunder, on behalf of the
Company (for purposes of this Section 7, including all predecessors of the
Company) and its affiliates, the Employee has had and from time to time will
have access to confidential records, data, customer lists, trade secrets and
other confidential information owned or used in the course of business by the
Company and its affiliates (the "Confidential Information").  The Employee
agrees (i) to hold the Confidential Information in strict confidence; (ii) not
to 

                                       5
<PAGE>
 
disclose the Confidential Information to any person (other than in the regular
business of the Company or its affiliates); and (iii) not to use, directly or
indirectly, any of the Confidential Information for any competitive or
commercial purpose other than on behalf of the Company and its affiliates;
provided, however, that the limitations set forth above shall not apply to any
Confidential Information which (A) is then generally known to the public; (B)
became or becomes generally known to the public through no fault of the
Employee; or (C) is disclosed in accordance with an order of a court of
competent jurisdiction or applicable law. Upon the termination of the Employee's
employment with the Company for any reason, all Confidential Information
(including, without limitation, all data, memoranda, customer lists, notes,
programs and other papers and items, and reproductions thereof relating to the
foregoing matters) in the Employee's possession or control, shall be immediately
returned to the Company or the applicable affiliate and remain in its or their
possession.

          (b)  The Employee recognizes that the Company and its affiliates
possess a proprietary interest in all of the information described in Section
7(a), subject to the provisions and limitations thereof, and have the exclusive
right and privilege to use, protect by copyright, patent or trademark, or
otherwise exploit the processes, ideas and concepts described therein to the
exclusion of the Employee, except as otherwise agreed between the Company and
the Employee in writing.  The Employee expressly agrees that any products,
inventions, discoveries or improvements made by the Employee or his agents or
affiliates in the course of the Employee's employment, including any of the
foregoing which is based on or arises out of the information described in
Section 7(a), shall be the property of and inure to the exclusive benefit of the
Company.  The Employee further agrees that any and all products, inventions,
discoveries or improvements developed by the Employee (whether or not able to be
protected by copyright, patent or trademark) during the course of his
employment, or involving the use of the time, materials or other resources of
the Company or any of its affiliates, shall be promptly disclosed to the Company
and shall become the exclusive property of the Company, and the Employee shall
execute and deliver any and all documents necessary or appropriate to implement
the foregoing.

          (c)  The Employee agrees, while he is employed by the Company, to
offer or otherwise make known or available to it, as directed by the Chief
Executive Officer of the Company and without additional compensation or
consideration, any business prospects, contracts or other business opportunities
that he may discover, find, develop or otherwise have available to him in any
field in which the Company or its affiliates are engaged, and further agrees
that any such prospects, contacts or other business opportunities shall be the
property of the Company.

     8.   Non-Competition.
          --------------- 

          In view of the fact that any activity of the Employee in violation of
the terms hereof would deprive the Company and its subsidiaries, if any, of the
benefits of their bargain under this Agreement, as a material inducement to and
a condition precedent of the Company's payment obligations hereunder and the
other covenants set forth herein, and to preserve the 

                                       6
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goodwill associated with the Boron, LePore business, the Employee hereby agrees
that during the term of the Employee's employment with the Company and its
subsidiaries and thereafter for a period of one year following the termination
of the Employee's employment with the Company, regardless of the circumstances
of termination, he will not, without the express written consent of the Company,
directly or indirectly, anywhere in the United States, engage in any activity
which is, or participate or invest in, or provide or facilitate the provision of
financing to, or assist (whether as owner, part-owner, shareholder, partner,
director, officer, trustee, employee, agent or consultant, or in any other
capacity), any business, organization or person other than the Company (or any
affiliate of the Company), whose business, activities, products or services are
competitive with any of the business, activities, products or services conducted
or offered by the Company and its subsidiaries at the time of the termination of
Employee's employment with the Company, which business, activities, products and
services shall include in any event peer influence meetings, telemarketing
activities, contract sales, field force logistics services and outsource
marketing involving pharmaceutical and healthcare companies. Without implied
limitation, the foregoing covenant shall include hiring or engaging or
attempting to hire or engage for or on behalf of himself or any such competitor,
any officer or employee of the Company or any of its direct and/or indirect
subsidiaries, encouraging for or on behalf of himself or any such competitor,
any such officer or employee to terminate his or her relationship or employment
with the Company or any of its direct or indirect subsidiaries, soliciting for
or on behalf of himself or any such competitor any client of the Company or any
of its direct or indirect subsidiaries and diverting to any person (as defined
in Section 14) any client or business opportunity of the Company or any of any
of its direct or indirect subsidiaries.

     Notwithstanding anything herein to the contrary, the Employee may make
passive investments in any enterprise the shares of which are publicly traded if
such investment constitutes less than five (5%) percent of the equity of such
enterprise.

     The Employee acknowledges that neither the Employee nor any business entity
controlled by him is a party to any contract, commitment, arrangement or
agreement which could, following the date hereof, restrain or restrict the
Company or any subsidiary or affiliate of the Company from carrying on its
business or restrain or restrict the Employee from performing his obligations
under this Agreement and as of the date of this Agreement the Employee has no
business interests in or relating to the pharmaceutical industry whatsoever
other than his interest in the Company, or interests in public companies of less
than five (5%) percent.  The Employee further acknowledges that he will not
bring to the premises of the Company any copies or other tangible embodiments of
non-public information belonging to or obtained from any previous employment or
other party.

     9.   Specific Performance; Severability.
          ---------------------------------- 

          It is specifically understood and agreed that any breach of the
provisions of Section 7 or 8 hereof by the Employee is likely to result in
irreparable injury to the Company and/or its affiliates, that the remedy at law
alone will be an inadequate remedy for such breach 

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and that, in addition to any other remedy it may have, the Company shall be
entitled to enforce the specific performance of this Agreement by the Employee
and to seek both temporary and permanent injunctive relief (to the extent
permitted by law), without the necessity of posting a bond or proving actual
damages. In case any of the provisions contained in this Agreement shall for any
reason be held to be invalid, illegal or unenforceable in any respect, any such
invalidity, illegality or unenforceability shall not affect any other provision
of this Agreement, but this Agreement shall be construed as if such invalid,
illegal or unenforceable provision had been limited or modified (consistent with
its general intent) to the extent necessary to make it valid, legal and
enforceable, or if it shall not be possible to so limit or modify such invalid,
illegal or unenforceable provision or part of a provision, this Agreement shall
be construed as if such invalid, illegal or unenforceable provision or part of a
provision had never been contained in this Agreement.

     10.  Assignability; Change of Control.
          -------------------------------- 

     This Agreement shall inure to the benefit of, and be binding upon and
assignable to, successors of the Company by way of merger, reorganization,
consolidation or other sale.  In addition, if the Company sells all or
substantially all of its assets, the Company will cause this Agreement to be
assumed by the buyer and if the buyer does not assume this Agreement, such non-
assumption shall be treated as a material breach under Section 6(f).  This
Agreement may not be assigned by the Employee.  Notwithstanding the foregoing or
any other provision of this Agreement to the contrary, in the event of  (a) the
sale of all or substantially all of the assets of the Company and its
Subsidiaries to another person or entity; (b) a merger, reorganization or
consolidation in which the holders of the Company's outstanding voting power
immediately prior to such transaction do not own a majority of the outstanding
voting power of the surviving or resulting entity immediately upon completion of
such transaction; (c) the sale of all or substantially all of the outstanding
stock of the Company to an unrelated person or entity in which the holders of
the Company's outstanding voting power immediately prior to such transaction do
not own a majority of the outstanding voting power of the surviving or resulting
entity immediately upon completion of such transaction; or (d) any other
transaction or series of transactions where the owners of the Company's
outstanding voting power immediately prior to such transaction do not own a
majority of the outstanding voting power of the surviving or resulting entity
immediately upon completion of such transaction (collectively, a "Change of
Control"), if, and within the 18 months thereafter, the Company terminates the
Employee's employment pursuant to Section 6(e) or the Employee terminates his
employment pursuant to Section 6(f), including for Good Reason (as hereinafter
defined), the Employee shall receive severance of two years Base Salary rather
than one year, payable through the second anniversary of such termination, in
addition to the bonus payment contemplated by Section 6(e).  For purposes of
this Agreement, "Good Reason" shall mean the occurrence of any of the following
events: (A) a substantial adverse change in the nature or scope of the
Employee's responsibilities, authorities, title, powers, functions, or duties;
(B) a reduction in the Employee's annual base salary except for across-the-board
salary reductions similarly affecting all or substantially all management
employees; or (C) the relocation of the offices at 

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<PAGE>
 
which the grantee is principally employed to a location more than fifty (50)
miles from Fair Lawn, New Jersey.

     11.  Notices.
          ------- 

          All notices, requests, demands and other communications hereunder
shall be in writing and shall be deemed to have been duly given if faxed (with
transmission acknowledgment received), delivered personally or mailed by
certified or registered mail (return receipt requested) as follows:

To the Company:     Boron, LePore & Associates, Inc.
                    17-17 Route 208 North
                    Fair Lawn, New Jersey  07410
                    Attention: Patrick G. LePore, President and CEO

To the Employee:    Brian Smith
                    Boron, LePore & Associates, Inc.
                    17-17 Route 208 North
                    Fair Lawn, New Jersey  07410
 

or to such other address or fax number of which any party may notify the other
parties as provided above.  Notices shall be effective as of the date of such
delivery, mailing or fax.

     12.  Dispute Resolution.  In the event of a dispute between the parties
          ------------------                                                
concerning their respective rights and obligations under this Agreement or under
any stock option agreement to which the Employee and the Company are party, that
the parties are unable to resolve amicably between themselves within sixty (60)
days of proper notice from one party to another, such dispute shall be settled
by arbitration in the State of New Jersey in an expedited manner in accordance
with the Commercial Rules of the American Arbitration Association by a duly
registered arbitrator to be selected jointly by the parties.  The decision of
the arbitrator shall be final and binding upon the parties.  Notwithstanding
anything to the contrary herein, the provisions of this Section 12 shall not
apply to any equitable remedies to which any party may be entitled to hereunder.

     13.  Litigation and Regulatory Cooperation.
          ------------------------------------- 

          During and after Employee's employment, the Employee shall reasonably
cooperate with the Company in the defense or prosecution of any claims or
actions now in existence or which may be brought in the future against or on
behalf of the Company which relate to events or occurrences that transpired
while the Employee was employed by the Company; provided, however, that such
cooperation shall not materially and adversely affect the Employee or expose the
Employee to an increased probability of civil or criminal litigation. The
Employee's cooperation in connection with such claims or actions shall include,
but not be 

                                       9
<PAGE>
 
limited to, being available to meet with counsel to prepare for discovery or
trial and to act as a witness on behalf of the Company at mutually convenient
times. During and after the Employee's employment, the Employee also shall
cooperate fully with the Company in connection with any investigation or review
of any federal, state or local regulatory authority as any such investigation or
review relates to events or occurrences that transpired while the Employee was
employed by the Company. The Company shall also provide the Employee with
compensation on an hourly basis calculated at his final base compensation rate
for requested litigation and regulatory cooperation that occurs after his
termination of employment, and reimburse the Employee for all costs and expenses
incurred in connection with his performance under this Paragraph 13, including,
but not limited to, reasonable attorneys' fees and costs.

     14.  Miscellaneous.
          ------------- 

          This Agreement shall be governed by and construed under the laws of
the State of New Jersey, and shall not be amended, modified or discharged in
whole or in part except by an agreement in writing signed by both of the parties
hereto.  The failure of either of the parties to require the performance of a
term or obligation or to exercise any right under this Agreement or the waiver
of any breach hereunder shall not prevent subsequent enforcement of such term or
obligation or exercise of such right or the enforcement at any time of any other
right hereunder or be deemed a waiver of any subsequent breach of the provision
so breached, or of any other breach hereunder.  This Agreement supersedes,
terminates and in all respects replaces all prior understandings and agreements,
written or oral, between the parties relating to the subject matter hereof,
including, without limitation, the Employee's employment contract dated August
18, 1997.  For purposes of this Agreement, the term "person" means an
individual, corporation, partnership, association, trust or any unincorporated
organization; a "subsidiary" of a person means any corporation more than 50
percent of whose outstanding voting securities, or any partnership, joint
venture or other entity more than 50 percent of whose total equity interest, is
directly or indirectly owned by such person; and an "affiliate" of a person
shall mean, with respect to a person or entity, any person or entity which
directly or indirectly controls, is controlled by, or is under common control
with such person or entity.
 

                                       10
<PAGE>
 
     IN WITNESS WHEREOF, the parties have executed this Agreement under seal as
of the date first set forth above.

                              BORON, LePORE & ASSOCIATES, INC.


                              By:   /s/ Patrick G. LePore
                                 -----------------------------
                                 Patrick G. LePore, President


                                /s/ Brian J. Smith
                              --------------------------------
                              BRIAN J. SMITH
 
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