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                                                                  Exhibit 10.22


                             AVAX TECHNOLOGIES, INC.

                        2000 DIRECTORS' STOCK OPTION PLAN

SECTION 1.    PURPOSE

         The purpose of the AVAX Technologies, Inc. 2000 Directors' Stock Option
Plan (the "Plan") is to advance the interests of AVAX Technologies, Inc., a
Delaware corporation (the "Company"), by strengthening the ability of the
Company to attract and retain External Directors (as defined below) of high
caliber through encouraging a sense of proprietorship by means of stock
ownership.

SECTION 2.    DEFINITIONS

         "Board" means the Board of Directors of the Company.

         "Code" means the Internal Revenue Code of 1986, as amended from
time-to-time.

         "Committee" means the entire Board of Directors, or if the
administration of this Plan has been delegated to a committee of the Board, a
committee selected by the Board and comprised of at least two directors. To the
extent necessary to comply with the requirements of Rule 16b-3, the Committee
shall consist of two or more Non-Employee Directors. The Compensation Committee
of the Board of Directors will act as the Committee for this Plan until such
time as the Board of Directors designates another committee of the Board or the
entire Board to act as the Committee for this Plan.

         "Common Stock" means the common stock of the Company, par value $.004
per share.

         "Date of Grant" means the date on which an Option is granted under this
Plan.

         "Designated Beneficiary" means the beneficiary designated by the
Optionee, in a manner determined by the Committee, to receive amounts due the
Optionee in the event of the Optionee's death. In the absence of an effective
designation by the Optionee, Designated Beneficiary means the Optionee's estate.

         "Exchange Act" means the Securities Exchange Act of 1934, as amended.

         "External Director" means a member of the Board who is not an employee
of the Company or a subsidiary.

         "Fair Market Value" means the closing sales price (or average of the
quoted closing bid and asked prices if there is no closing sales price reported)
of the Common Stock on the date specified as reported by the NASDAQ Stock
Market, or by the principal national stock exchange on which the Common Stock is
then listed. If there is no reported price information for such date, the Fair
Market Value will be determined by the reported price information for Common
Stock on the day nearest preceding such date.

         "Option" means a nonqualified option to purchase shares of the
Company's Common Stock.

         "Optionee" means the person to whom an Option is granted under this
Plan or who has obtained the right to exercise an Option in accordance with the
provisions of this Plan.

         "Rule 16b-3" means Rule 16b-3 of the rules and regulations under the
Exchange Act as it may be amended from time-to-time and any successor provision
to Rule 16b-3 under the Exchange Act.


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SECTION 3.    ADMINISTRATION

         This Plan shall be administered by the Committee. The Committee shall
have sole and complete authority to adopt, alter and repeal such administrative
rules, guidelines and practices governing the operation of this Plan as it shall
from time-to-time deem advisable, and to construe, interpret and administer the
terms and provisions of this Plan and the agreements thereunder. The
determinations and interpretations made by the Committee are final and
conclusive and binding on all persons.

SECTION 4.    ELIGIBILITY

         All External Directors are eligible to receive awards of Options under
this Plan.

SECTION 5.    MAXIMUM AMOUNT AVAILABLE FOR AWARDS

         Subject to the provisions of SECTION 9, the maximum number of shares of
Common Stock in respect of which Options may be granted under this Plan is
480,000 shares of Common Stock. Shares of Common Stock may be made available
from authorized but unissued shares of the Company or from shares reacquired by
the Company, including shares purchased in the open market. In the event that an
Option is terminated unexercised as to any shares of Common Stock covered
thereby, such shares shall thereafter be again available for award pursuant to
this Plan.

SECTION 6.    STOCK OPTIONS

         (a) Options will be automatically granted to each External Director
under this Plan as follows:

                  (1) On the date of the adoption of this Plan by the Board of
         Directors, each External Director of the Company as of January 1, 2000,
         shall be granted nonqualified Options to purchase 40,000 shares of the
         Company's Common Stock at an Option exercise price equal to 100% of the
         Fair Market Value of the Common Stock on the date of the adoption of
         this Plan by the Board of Directors.

                  (2) During the term of this Plan, on the day that an External
         Director is first appointed or elected to the Board, such director
         shall be granted nonqualified Options to purchase 40,000 shares of the
         Company's Common Stock at an Option exercise price equal to 100% of the
         Fair Market Value of the Common Stock on the date the External Director
         is elected to the Board of Directors or first becomes an External
         Director.

                  (3) On the first business day of January 2004, each External
         Director shall be granted nonqualified Options to purchase 40,000
         shares of the Company's Common Stock at an Option exercise price equal
         to 100% of the Fair Market Value of the Common Stock on the first
         business day of January 2004.

         (b) All Options granted under this Plan prior to stockholder approval
of this Plan are subject to the approval of this Plan by the stockholders of the
Company.

         (c) Each Option hereunder shall be evidenced in writing, delivered to
the Optionee, and will be exercisable at such times and subject to such terms
and conditions as specified in the applicable grant and agreement, subject to
the following:

                  (1) the initial grant of Options to purchase 40,000 shares of
         Common Stock to the External Directors as of January 1, 2000, shall
         vest quarterly on a proportionate basis on each January 1, April 1,
         July 1 and October 1, beginning with January 1, 2000, and quarterly
         thereafter


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         over the next 15 quarters so long as the External Director continues as
         a member of the Board of Directors; provided, that, the vesting will
         accelerate if a Change in Control (as defined in the applicable
         agreement) of the Company occurs; and

                  (2) the Options granted to any new External Director shall
         vest quarterly on a proportionate basis on each January 1, April 1,
         July 1 and October 1, beginning with the first January 1, April 1, July
         1 or October 1 closest to (before or after) the Date Of Grant, and
         quarterly thereafter over the next 15 quarters so long as the External
         Director continues as a member of the Board of Directors; provided,
         that, the vesting will accelerate if a Change in Control (as defined in
         the applicable agreement) of the Company occurs; and

                  (3) the grant of Options to purchase 40,000 shares of Common
         Stock to the External Directors as of January 1, 2004, shall vest
         quarterly on a proportionate basis on each January 1, April 1, July 1
         and October 1, beginning with January 1, 2004, and quarterly thereafter
         over the next 15 quarters so long as the External Director continues as
         a member of the Board of Directors; provided, that, the vesting will
         accelerate if a Change in Control (as defined in the applicable
         agreement) of the Company occurs; and

                  (4) the Options may not be exercised after the tenth
         anniversary of the Date of Grant.

         The Committee may impose such conditions with respect to the exercise
of Options (that are consistent with the foregoing principles), including
without limitation, any relating to the application of federal or state
securities laws, as it may deem necessary or advisable.

         (e) No shares may be delivered pursuant to any exercise of an Option
until payment in full of the option price therefor is received by the Company.
The Company shall have the right to deduct from all amounts paid to an Optionee
in cash (whether under this Plan or otherwise) any taxes the Company withholds
in respect of Options under this Plan.

         (f) The Company is not required to issue any fractional shares upon the
exercise of any Options granted under this Plan. No Optionee or such Optionee's
legal representatives, legatees or distributees, as the case may be, will be, or
will be deemed to be, a holder of any shares subject to an Option unless and
until said Option has been exercised and the purchase price of the shares in
respect of which the Option has been exercised has been paid. Unless otherwise
provided in the agreement applicable thereto, an Option is not exercisable
except by the Optionee or by a person who has obtained the Optionee's rights
under the Option by will or under the laws of descent and distribution or
pursuant to a "qualified domestic relations order" as defined in the Code, and
no right or interest of any Optionee shall be subject to any lien, obligation or
liability of the Optionee.

SECTION 7.    PLAN AMENDMENTS

         The Board may amend, abandon, suspend or terminate this Plan or any
portion thereof at any time in such respects as it may deem advisable in its
sole discretion, provided that no amendment may be made without stockholder
approval if such amendment is material or if stockholder approval is necessary
to comply with any tax or regulatory requirement.

SECTION 8.    RESTRICTIONS ON ISSUANCE OF OPTIONS AND OPTION SHARES

         The Company is not obligated to issue any shares upon the exercise of
any Option granted under this Plan unless: (1) the shares pertaining to such
Option have been registered under applicable securities laws or are exempt from
such registration; (2) if required, the prior approval of such sale or issuance
has been obtained from any state regulatory body having jurisdiction; and (3) if
the Common Stock has been listed on any exchange, the shares pertaining to such
Option have been duly listed on such exchange in accordance with the procedure
specified therefor. The Company is under no obligation to effect or obtain


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any listing, registration, qualification, consent or approval with respect to
shares pertaining to any Option granted under this Plan. If the shares to be
issued upon the exercise of any Option granted under this Plan are intended to
be issued by the Company in reliance upon the exemptions from the registration
requirements of applicable federal and state securities laws, the recipient of
the Option, if so requested by the Company, shall furnish to the Company such
evidence and representations, including an opinion of counsel satisfactory to it
as the Company may reasonably request.

         The Company shall not be liable for damages due to a delay in the
delivery or issuance of any stock certificates for any reason whatsoever,
including, but not limited to, a delay caused by listing, registration or
qualification of the shares of Common Stock pertaining to any Option granted
under this Plan upon any securities exchange or under any federal or state law
or the effecting or obtaining of any consent or approval of any governmental
body.

         The Committee may impose such other restrictions on the ownership and
transfer of shares issued pursuant to this Plan as it deems desirable; any such
restrictions shall be set forth in the agreement applicable thereto.

SECTION 9.    ADJUSTMENT TO SHARES

         If the Committee determines that any stock dividend, recapitalization,
reorganization, merger, consolidation, split-up, spin-off, combination, exchange
of shares, warrants or rights offering to purchase Common Stock at a price
substantially below Fair Market Value or other similar corporate event affects
the Common Stock such that an adjustment is required in order to preserve the
benefits or potential benefits intended to be made available under this Plan,
then the Committee shall adjust appropriately any or all of (a) the number and
kind of shares that thereafter may be optioned under this Plan, (b) the number
and kind of shares subject of Options, and (c) the exercise price with respect
to any of the foregoing and/or, if deemed appropriate, make provision for cash
payment to an Optionee or a person who has an outstanding Option; provided,
however, that the number of shares subject to any Option shall always be a whole
number.

SECTION 10.     EFFECTIVE DATE; TERM

         Subject to the approval of the stockholders of the Company, this Plan
is effective as of the January 1, 2000. No Options may be granted under this
Plan after December 31, 2009; however, all previously granted Options that have
not expired under their original terms or will not then expire at the time this
Plan expires will remain outstanding.

SECTION 11.     GENERAL PROVISIONS

         (a) Neither this Plan nor any Option granted hereunder is intended to
confer upon any Optionee any rights with respect to continuance of the
utilization of his or her services by the Company, nor to interfere in any way
with his or her right or that of the Company to terminate his or her services at
any time (subject to the terms of any applicable contract, law, regulation, and
the articles and bylaws of the Company).

         (b) No Optionee or Designated Beneficiary has any rights as a
stockholder with respect to any shares of Common Stock to be distributed under
this Plan until he or she has become the holder thereof.

         (c) The validity, construction, interpretation, administration and
effect of this Plan and of its rules and regulations, and rights relating to
this Plan, shall be determined solely in accordance with the laws of the State
of Delaware (without giving effect to its conflicts of laws rules) and, to the
extent applicable, federal law.


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         The Company has caused this Plan to be adopted by its Board of
Directors effective as of January 1, 2000.

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