1

Pyrethrins, PBO, MGK-264 Combination Label Table 

This label table incorporates all of the required label changes from the pyrethrins, PBO, and MGK-264 REDs. 

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

All Products

Ingredient statements for 

piperonyl butoxide

--Delete any reference to “technical” in the ingredient statement. (i.e. Some labels refer to PBO 

technical as the active ingredient.)

-- Do not include a ratio of PBO components or percent of other related compounds in the footnote. 

Following is an example of an acceptable expression of the PBO ingredient statement:

Piperonyl butoxide* ......................................................100%

*(butyl carbityl)(6-propylpiperonyl) ether and related compounds

Ingredient Statement 

End-Use Products Intended for Occupational Use (WPS and non-WPS) 

And Wide Area Mosquito Adulticide Applications

[Note: For products with both occupational and consumer homeowner uses, the more restrictive language from these labeling tables must be used.]

Handler PPE Requirements 

for Liquid Formulations1

[including: liquid 

concentrates, total release 

foggers, microencapsulated 

concentrates, foams, 

aerosols, gels, pastes, and 

pressurized liquids]

Note: The statement may 

be omitted if the end-use 

product is labeled only for 

use on pets. 

“Personal Protective Equipment (PPE)”

“Mixers, loaders, applicators, and other handlers must wear the following:

- long-sleeve shirt, 

- long pants, 

- shoes and socks.”

“In addition to the above PPE, applicators using a high pressure handwand in an enclosed area must 

wear at least a NIOSH-approved respirator with:

-- a dust/mist filter with MSHA/NIOSH approval number prefix TC-21C or

-- any N, R, P, or HE filter.”

“In addition to the above PPE, applicators using hand held foggers in an enclosed area must wear a 

Precautionary 

Statements: Hazards to 

Humans and Domestic 

Animals
2

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

Note: If the use of

handheld foggers in 

enclosed areas is not 

permitted or not feasible for 

the end-use product, the 

statement requiring 

respirators for those uses 

may be omitted.

half-face, full-face, or hood-style NIOSH-approved respirator with:

-- a dust/mist filtering cartridge (MSHA/NIOSH approval number prefix TC-21C), or

-- a canister approved for pesticides (MSHA/NIOSH approval number prefix TC-14G), or 

-- a cartridge or canister with any N,R,P or HE filter.”

“See engineering controls for additional requirements.” 

Instruction to Registrant: 

Drop the “N” type filter from the respirator statement, if the pesticide product contains, or is used 

with, oil.

Handler PPE Requirements 

for Dusts1

“Personal Protective Equipment (PPE)”

“Loaders, applicators, and other handlers must wear the following:

- long-sleeve shirt, 

- long pants, 

- shoes and socks.”

Precautionary 

Statements: Hazards to 

Humans and Domestic 

Animals

User Safety Requirements “Follow manufacturer's instructions for cleaning/maintaining PPE. If no such instructions for 

washables exist, use detergent and hot water. Keep and wash PPE separately from other laundry.”

“Discard clothing and other absorbent material that have been drenched or heavily contaminated 

with the product’s concentrate. Do not reuse them.” 

Precautionary 

Statements: Hazards to 

Humans and Domestic 

Animals immediately 

following the PPE 

requirements

Environmental 

Hazards Statements for 

products labeled for outdoor 

uses 

“ENVIRONMENTAL HAZARDS”

“This product is toxic to aquatic organisms, including fish and invertebrates. Drift and runoff may 

be hazardous to aquatic organisms in water adjacent to treated areas. This product may contaminate 

water through runoff. This product has a potential for runoff for several months or more after 

application. Poorly draining soils and soils with shallow water tables are more prone to produce 

runoff that contains this product.” 

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

Precautionary 

Statements under 

Environmental Hazards 
3

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

“Do not apply directly to water, to areas where surface water is present or to intertidal areas below

the mean high water mark. Do not contaminate water when disposing of equipment wash-waters or 

rinsate.”

 

Environmental Hazards for 

Products labeled only for 

Indoor Use 

No environmental hazard statement is required for products labeled for indoor use only.

For indoor products packaged in containers equal to or greater than 5 gallons or 50 lbs add 

the following statement:

“Do not discharge effluent containing this product into lakes, streams, ponds, estuaries, oceans, or 

other waters unless in accordance with the requirements of a National Pollution Discharge 

Elimination System (NPDES) permit and the permitting authority has been notified in writing prior 

to discharge. Do not discharge effluent containing this product to sewer systems without previously 

notifying the local sewage treatment plant authority. For guidance contact your State Water Board 

or Regional Office of the EPA."

Precautionary 

Statements under 

Environmental Hazards

Environmental hazard 

statements on Liquid 

Concentrate consumer

outdoor products (e.g., 

liquids mixed with water by 

the user for a tank sprayer 

or hose-end attachment)

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. To protect the 

environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or 

surface waters. Applying this product in calm weather when rain is not predicted for the next 24 

hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.

Rinsing application equipment over the treated area will help avoid run off to water bodies or 

drainage systems.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental Hazard 

Statement

Environmental hazard 

statements on Dusts 

consumer outdoor products 

(e.g., for garden or 

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. To protect the 

environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or 

surface waters. Applying this product in calm weather when rain is not predicted for the next 24 

Environmental Hazard 

Statement
4

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

ornamental) hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental hazard 

statements on Ready-to-Use 

consumer outdoor products

(except aerosols and 

foggers)

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. To protect the 

environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or 

surface waters. Applying this product in calm weather when rain is not predicted for the next 24 

hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental Hazard 

Statement

Environmental Hazard 

Statements for Ready to 

Use aerosol and fogger 

consumer outdoor products

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. Do not apply directly 

to or near water. Drift and run-off may be hazardous to fish in water adjacent to treated areas. Do 

not contaminate water when disposing of equipment, washwater, or rinsate. See Directions for Use 

for additional precautions and requirements.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental Hazard 

Statement

Restricted-Entry Interval 

for products with WPS uses 

“Do not enter or allow worker entry into treated areas during the restricted entry interval (REI) of 

12 hours.”

Directions for Use, 

Agricultural Use 

Requirements Box

Early Entry Personal 

Protective Equipment for 

products with WPS uses 

“PPE required for early entry to treated areas that is permitted under the Worker Protection 

Standard and that involves contact with anything that has been treated, such as soil or water, is:

- coveralls,

- shoes plus socks, and

- chemical-resistant gloves made of any waterproof material.”

Directions for Use, 

Agricultural Use 

Requirements Box

Entry Restrictions 

for products with non-WPS 

uses on the label

Entry Restriction for products applied as a surface spray (does not apply to products applied 

directly to humans or domestic animals or applied when people are permitted to be present): 

If no WPS uses on the 

product label, place the 

appropriate statement 
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Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

Note: This excludes 

products labeled for use 

when people are permitted 

to be present (e.g. metered 

release devices and

applications to pets)

“Do not enter or allow others to enter until sprays have dried.”

Entry Restriction for products applied dry:

“Do not enter or allow others to enter until dusts have settled.”

Entry Restriction for products applied as a space spray:

“Do not allow adults, children, or pets to enter the treated area for at least 15 minutes, until vapors, 

mists, and aerosols have dispersed, and the treated area has been thoroughly ventilated.”

Total release foggers labeled for indoor use must contain the following entry restriction:

“Wait two (2) hours after application, then open windows, vents and doors for two hours. In an 

odor is still detected additional ventilation is required.” 

Note to Registrant: If there is information that justified a change in the duration after application (2 

hours), submit the information to the Agency.

in the Directions for 

Use Under General 

Precautions and 

Restrictions. If the 

product also contains 

WPS uses, then create a 

Non-Agricultural Use 

Requirements box as 

directed in PR Notice 

93-7 and place the 

appropriate statement 

inside that box.

Entry Restrictions for 

products labeled solely for 

use when people are present 

(e.g metered release devices 

and applications to pets)

Note to Registrants: No entry restrictions are required. See below under Use Restrictions for 

further requirements. 

Entry Restrictions for 

products labeled for use 

when people are present 

(e.g. metered release 

devices and applications to 

pets) and for use on other 

sites as a directed or space 

spray.

Products labeled for use as a directed spray (does not apply to products applied directly to 

domestic animals): 

“Except when (insert application method or site that allows people to be present), do not enter or 

allow others to enter until sprays have dried.”

Products labeled for use as a space spray:

“Except when (insert application method or site that allows people to be present), do not enter or 

If no WPS uses on the 

product label, place the 

appropriate statement 

in the Directions for 

Use Under General 

Precautions and 

Restrictions. If the 

product also contains 

WPS uses, then create a 

Non-Agricultural Use 
6

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

allow others to enter until vapors, mists, and aerosols have dispersed, and the treated area has been 

thoroughly ventilated.”

Note to Registrant: An example is as follows: Except when applying in a metered release system, 

do not enter or allow others to enter until sprays have dried.

Requirements box as

directed in PR Notice 

93-7 and place the 

appropriate statement 

inside that box.

General Application 

Restrictions for products 

with WPS or non-WPS uses 

on the label

Note: This excludes 

products that contain any 

directions for uses when 

people are permitted to be 

present in the treated area 

(e.g. metered release 

devices and applications to 

pets) 

“Do not apply this product in a way that will contact workers or other persons, either directly or 

through drift.” 

“Only protected handlers may be in the area during application.”

Place in the Direction 

for Use.

General Application 

Restrictions for products 

with WPS and non-WPS 

uses on the label AND 

contain directions for uses 

when people are permitted 

to be present in the treated 

area (e.g. metered release

devices and applications to 

pets)

“Except when” (insert application method or site that allows people to be present) “do not apply this 

product in a way that will contact workers or other persons, either directly or through drift.” 

“Except when” (insert application method or site that allows people to be present) “only protected 

handlers may be in the area during application.”

Place in the Direction 

for Use. 

General Application 

Restrictions for products 

labeled for use solely when 

people are permitted to be 

Note to Registrants: No entry restrictions are required. See below under Use Restrictions for 

further requirements. 

Place in the Direction 

for Use. 
7

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

present in the treated area 

(e.g., metered-release 

devices and applications to 

pets)

Formulation Specific 

Restrictions

Note: the following restrictions apply to any product formulated with MGK-264:

Ready-to-use formulated products for use on pets eligible for reregistration must not contain a 

percentage of a.i. that exceeds the following:

Shampoos – 1.0 % ai MGK-264

Sprays – 2.5% ai MGK-264

Spot-on or Pour-on – 1.0 % ai MGK-264

Mousse, soap, lotion, roll-on, or gel – 0.5 % ai MGK-264

Comb – 0.5 % ai MGK-264

Wipe or rub – 1.5 % ai MGK-264

Towelettes-2% ai MGK-264

In addition for collars and dips, products must not contain a percentage of a.i. of MGK-264 that 

exceeds the following:

Collar – 0.0022 lbs ai MGK-264/collar

Dip – 0.3 % ai MGK-264 per ounce of dip 

Direct Application to Non-domestic Animals (non-food livestock only, i.e. donkeys, horses, 

ponies, mules)

Formulated products must not contain a percentage of a.i. that exceeds the following:

Towelettes for application to horses– 37.5 mg ai/ MGK-264 towelette (or 0.0000826 lbs ai MGK264/wipe) 

All MGK-264 

products must not be 

formulated with more 

than the concentration 

indicated 

Other Application 

Restrictions

Note to Registrants: Delete any reference to tolerance exemptions on labels.

Not for formulation into products with directions for use in mosquito abatement applications.

In addition add the following restrictions depending on the registered product uses and formulation:

Directions for Use 

under Use Restrictions
8

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

All formulations labeled or intended for outdoor residential uses:

“Do not make applications during rain.”

Dust formulations:

“Aerial applications are prohibited.”

“Applications with power duster equipment are prohibited.”

“Applications to pets are prohibited.”

 

Products labeled for use as a space spray excluding metered release devices:

“Do not remain in treated area. Exit area immediately and remain outside the treated area until 

aerosols, vapors, and/or mists have dispersed.”

Products labeled for spray applications to plants:

“Do not wet plants to point of runoff or drip.”

Products labeled for spray applications to articles:

“Do not wet articles to point of runoff or drip.”

“Do not use treated article until spray has dried.”

Products labeled for applications to clothing articles:

“Dry clean treated clothes before wearing.”

Products labeled for dip applications to empty containers:

“Do not use treated article before it is dry.”

Products labeled for crack and crevice, surface or space spray, fogging or dust applications 

(including pet areas) indoors excluding metered release devices: 

“Remove or cover exposed food and drinking water before application.”

“Remove or cover dishes, utensils, food processing equipment, and food preparation surfaces, or 

wash them before use.” 
9

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

Products labeled for applications to non-residential indoor sites:

“Do not use in aircraft cabins except in compliance with PR Notice 96-3.” 

“When used in dairy barns or facilities: Close milk bulk tank lids to prevent contamination from 

spray and from dead or falling insects. Remove or cover milking utensils before application. Wash 

teats of animals before milking.”

Products labeled for use in food handling and processing facilities excluding metered release 

devices: 

“Do not make space spray applications when facility is in operation.”

“Prior to space spray applications, cover or remove food.”

“Prior to space spray applications, cover food processing surfaces or clean after treatment and 

before use.”

Use-Specific Application 

Restrictions

(Note: The maximum 

allowable application rate 

and maximum allowable 

seasonal rate must be listed 

as ppm or pounds or gallons 

of formulated product per 

acre/square feet/cubic feet, 

etc., not just as pounds 

active ingredient per acre. 

All rates must be expressed 

in terms the applicator can 

use in order to arrive at the 

maximum application rate. 

For example, for sprays 

rates must specify the 

duration of spray to a 

Except as noted below, the following rate changes apply only to MGK.

PBO Changes:

The maximum PBO rate for indoor crack and crevice spray is 0.56 lbs ai/1000 square feet.

The maximum space spray rate for post-harvest application to fruits, vegetables, and nuts is 0.01 lbs 

PBO per 1000 cubic feet.

Formulated indoor space spray products eligible for reregistration must not contain more than 0.05 

lbs PBO/16 ounce can.

Formulated pet spray products eligible for reregistration must not contain more than 10 % piperonyl 

butoxide. 

Pyrethrins Changes:

Directions for Use 

under Use Restrictions
10

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

specific area, i.e., spray for 

X seconds to a space Y feet 

by Z feet.)

The maximum space spray rate for post-harvest applications to fruits, vegetables and copra is 0.001 

lbs pyrethrins per 1000 cubic feet. 

The maximum space spray rate for food handling establishments is 0.0033 lbs pyrethrins per 1000 

cubic feet.

The maximum space spray rate for residential areas is 0.00033 lbs pyrethrins per 1000 cubic feet.

Formulated pet spray products eligible for reregistration must not contain more than 0.2 % 

pyrethrins. 

All other Pyrethrins and PBO rate changes are included in Appendix A.

Note to Registrant: In addition, these label statements should be deleted from all products 

registered for food handling and processing facilities: 

“Except in Federally inspected meat and poultry plants, food processing operations may 

continue when the product is applied as a general surface spray/crack and crevice spray with 

care and in accordance with the directions and precautions on the label, at a maximum rate of 

X pounds of product per 1000 square feet.” 

MGK Rate Changes:

Trigger Pump Sprayers 

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

All trigger pump sprayers - 0.1 lbs ai/1000 square feet (maximum concentration is 0.5 % ai)

Indoor Aerosol Space Sprays (Residential Areas)

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

All aerosol pump sprayers used in residential areas- 0.00015 lbs ai/1000 cubic foot

Non-food (ornamentals, flowering, and foliage plants) plants in Commercial Greenhouses 
11

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

Maximum application rates:

Greenhouse surface spray – 0.01 lbs per 1000 square feet 

Greenhouse space sprays - 0.001 lbs ai/1000 cubic feet

Use restrictions:

“Do not apply more than 1 time per day.”

Direct Application to Non-domestic Animals (non-food livestock only, i.e. donkeys, horses, 

ponies, mules)

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Application to non-food livestock– 0.00025 lbs ai/animal (or 2 oz of 0.2% spray/animal) 

Ready-to-use paste applications to horses – 0.0056 lbs ai/horse 

Use restrictions:

“Do not apply more than 1 time per day.”

Indoor Agricultural Premises and Commercial Animal Housing and Equipment (animals not 

present)

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Crack/crevice or spot– 0.05 lbs ai/1000 square feet 

Surface applications – 0.01 lbs ai/1000 square feet 

Space sprays – 0.001 lbs ai/1000 cubic feet 

Metered release device sprays – 0.002 lbs ai/ 1000 cubic feet per day and 1.77 mg ai/spray 

event 

Use Restrictions:

“Do not apply more than 1 time per day.”

Indoor Food Handling/Processing Facilities
12

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

Products must be formulated to deliver no more than the maximum rate when used according 

to directions:

Surface applications – 0.01 lbs ai/1000 square feet

Crack/crevice or spot – 0.05 lbs ai/1000 square feet

Space sprays– 0.001 lbs ai/1000 cubic feet 

Metered release device space sprays – 0.002 lbs ai/1000 cubic feet/day and 1.77 mg ai/spray 

event 

Use Restrictions:

“Do not apply more than 1 time per day.”

Outdoor Agriculture Premises and Equipment

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Surface applications – 0.01 lbs ai/1000 square feet 

Crack/crevice or spot– 0.05 lbs ai/1000 square feet

Use Restrictions:

“Do not apply more than 1 time per day.”

Pet Care

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

The use directions must not allow more than 0.0028 lbs ai/pet for all pet applications, 

including those listed above.

Use restrictions:

“Do not apply to pets less than 12 weeks old.”

“Consult a veterinarian before applying this product on medicated, debilitated, aged, pregnant, 

or nursing animals.”

“Sensitivities may occur after using any pesticide product for pets. If signs of sensitivity occur 

bathe your pet with mild soap and rinse with large amounts of water. If signs continue, 
13

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

consult a veterinarian immediately.”

Registrant Note: Follow instructions in PR Notice 96-6, Pet Pesticide Product Label 

Statements, for including reapplication restrictions on the end-use product label.

Pet Premise Treatment (pets are not present)

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Surface – 0.01 lbs per 100 square feet

Space spray – 0.001 lbs per 1000 square feet

Outdoor Residential Ornamental and Lawns

Maximum application rates: 

Surface applications – 0.3 lbs ai/A 

User Restrictions:

“Do not apply more than 1 time per day.”

Residential Dwellings and Commercial, Institutional Indoor Sites

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Surface applications –0.01 lbs ai/1000 square feet

Crack/crevice or spot – 0.05 lbs ai/1000 square feet 

Space sprays– 0.001 lbs ai/1000 cubic feet 

Metered release device space sprays (except for residential dwellings which are prohibited)–

0.002 lbs ai/1000 cubic feet/day and 1.77 mg ai/spray event 

Residential Indoor Dust Applications to Carpet and Other Indoor Surfaces

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Dust – 0.011 lbs ai/100 square feet
14

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

User Restrictions:

“Do not apply more than once a day.”

“Only apply as a spot treatment to areas no greater than 3 feet by 3 feet per room.”

General Outdoor Sites (including non-agricultural rights-of-way, 

commercial/institutional/industrial premises, residential sites, and outdoor eating 

establishments)

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Surface applications – 0.01 lbs ai/1000 square feet

Crack/crevice or spot – 0.05 lbs ai/1000 square feet

Metered release device space sprays (except for residential sites which are prohibited) – 0.002

lbs ai/1000 cubic feet/day and 1.77 mg ai/spray event 

Manholes

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Surface applications to manholes – 0.07 lbs ai per manhole over a length of 200 feet 

Use restrictions:

“Do not apply more than 1 time per day.”

Food Stored in Bags

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Space sprays may be made to the surfaces of bags of stored food products at the rate of 0.001 

lbs ai/1000 cubic foot.

Use restrictions:

“Direct application to food contact surfaces is prohibited.” 

Application Restrictions for Note to Registrants: Delete nurseries, day care centers, schools, hospitals, and nursing homes as Directions for Use 
15

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

products used in Metered 

Release Devices

registered use sites on all product labels for this use pattern.

Add the following statements:

“Not for use in Residential areas.”

“Do not use in nurseries or rooms where infants, ill, or aged persons are present.”

“Do not place metering device directly over or within 8 feet of exposed food, dishes, utensils, food 

processing equipment, and food handling or preparation.”

“Do not install within 3 feet of air vents.”

“Carefully follow directions for the dispenser unit when installing the dispenser and replacing cans 

or conducting maintenance.” 

“The maximum application rate for metered release devices is 0.00046 lb pyrethrin per 1000 cubic 

feet.” 

under Use Restrictions

Indoor Misting Systems 

Used in Commercial Barns, 

Stables, and Animal 

Quarters

“Directions for use in commercial animal premise automatic misting systems”

“Not for use in outdoor residential misting systems (indoor or outdoor).”

“Do not apply this product in barns or stables where animals intended for slaughter or human 

consumption will be maintained.”

“Do not apply when food, feed, and/or water is present.”

“When using this product, installers and service technicians must comply with the license, 

certification, or registration requirements of the state(s), tribe(s), or local authority(ies) where they 

are installed.” 

“When applying via a remote activation device, do not apply when people and pets are present. If 

possible, when applying via automatic timer, set the timing for application when people and pets 

are unlikely to be present.”

“Direct nozzles to spray towards the target area and away from areas where people are typically 

present.”

“Do not use in an evaporative cooling system.”

Directions for Use 

under Use Restrictions
16

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

“Do not use in misters located within 3 feet of air vents, air conditioner units, or windows.”

“If used in a system with a reservoir tank for the end use dilution, the system reservoir tank must be 

locked. Securely attach the end use pesticide label and a dilution statement to the system reservoir 

tank in a weather protected area or plastic sleeve. The dilution statement must be phrased as 

follows: this container holds __ parts [product name] to __ parts water”

“If used in a direct injection system, the pesticide container must be locked. Securely attach the 

end use label to the pesticide container in a weather protected area or plastic sleeve.” (These 

instructions not applicable to wettable powder products). 

“This product must only be used in systems that have been calibrated to apply no more than the 

maximum application rate of” [insert product application rate]. 

Note to registrant: Also express this application rate as pounds or gallons of end-use product 

formulation.

Use-Specific Application 

Restrictions for all products 

that could feasibly be used 

in an outdoor residential 

misting system 

Note to registrants: No 

products for use in outdoor 

residential misting systems 

will be eligible for 

reregistration

Outdoor Residential Misting Systems

Products not intended for use in outdoor residential misting systems must contain the 

following statement: 

“Not for use in outdoor residential misting systems.”

Directions for Use 

under Use Restrictions

Products Primarily Used by Consumers/Homeowners

[Note: For products with both occupational and consumer homeowner uses, the more restrictive language from these labeling tables must be used.]

Entry Restrictions 

for products that do not

contain any directions for 

uses when people are 

Entry Restriction for products applied as a surface or crack and crevice spray except for 

sprays applied directly to domestic animals: 

“Do not allow adults, children, or pets to enter the treated area until sprays have dried.”

Directions for use 

under General 

Precautions and 

Restrictions
17

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

permitted to be present in 

the treated area (e.g. . 

applications to pets)

Entry Restriction for products applied dry:

“Do not allow adults, children, or pets to enter the treated area until dusts have settled.”

Entry Restriction for products applied as a space spray:

“Do not allow adults, children, or pets to enter the treated area for at least 15 minutes, until vapors, 

mists, and aerosols have dispersed, and the treated area has been thoroughly ventilated.”

Total release foggers labeled for indoor use must contain the following entry restriction:

“Wait two (2) hours after application, then open windows, vents and doors for two hours. In an

odor is still detected additional ventilation is required.” 

Note to Registrant: If there is information that justified a change in the duration after application (2 

hours), submit the information to the Agency.

Entry Restrictions for 

products that only contain 

directions for uses when 

people are permitted to be 

present (e.g. pet

applications)

Note to Registrants: No entry restrictions are required. See below under Use Restrictions for 

further requirements. 

Directions for use 

under General 

Precautions and 

Restrictions

Entry Restrictions for 

products that contain 

directions for uses when 

people are permitted to be 

present in the treated area 

(e.g. applications to pets) 

AND for use on other sites 

as a surface and/or crack 

and crevice spray.

Products labeled for use as a surface spray (does not apply to products applied directly to 

domestic animals): 

“Except when applying directly to pets, do not allow adults, children, or pets to enter until sprays 

have dried.”

Directions for use 

under General 

Precautions and 

Restrictions

General Application 

Restrictions for all products 

“Do not apply this product in a way that will contact adults, children, or pets, either directly or 

through drift.” 

Place in the Direction 

for Use 
18

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

except those that contain 

directions for use when 

people are permitted to be 

present in the treated area 

(e.g., applications to pets)

“Remove pets, birds, and cover fish aquariums before use.”

General Application 

Restrictions for products 

that ONLY contain 

directions for uses when 

people are permitted to be 

present (e.g. pet 

applications)

Note to Registrants: No entry restrictions are required. See below under Use Restrictions for 

further requirements. 

Place in the Direction 

for Use 

General Application 

Restrictions for products 

that contain directions for 

uses when people are 

permitted to be present in 

the treated area (e.g. 

applications to pets) AND 

for use on other sites as a 

surface spray.

“Except when applying directly to pets, do not apply this product in a way that will contact adults, 

children, or pets, either directly or through drift.” 

“Remove pets, birds, and cover fish aquariums before use.”

Place in the Direction 

for Use 

Other Application 

Restrictions (as applicable)

Note to Registrants: Delete any reference to tolerance exemptions on labels.

In addition add the following restrictions depending on the registered product uses and formulation:

All formulations labeled or intended for outdoor residential uses:

“Do not make applications during rain.”

Dust formulations:

“Aerial applications are prohibited.”

“Applications with power duster equipment are prohibited.”

“Applications to pets are prohibited.”

“Only apply as a spot treatment to areas no greater than 3 feet by 3 feet per room.”

Directions for Use 

under Use Restrictions
19

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

Products labeled for use as a space spray excluding metered release devices:

“Do not remain in treated area. Exit area immediately and remain outside the treated area until 

aerosols, vapors, and/or mists have dispersed.”

Products labeled for spray applications to plants:

“Do not wet plants to point of runoff or drip.”

Products labeled for spray applications to articles:

“Do not wet articles to point of runoff or drip.”

“Do not use treated article until spray has dried.”

Products labeled for applications to clothing articles:

“Dry clean treated clothes before wearing.”

Products labeled for dip applications to empty containers:

“Do not use treated article before it is dry.”

Liquid, Dust, and Ready-To-Use products intended for outdoor residential use:

“Do not water the treated area to the point of run-off.”

Products labeled for crack and crevice, surface or space spray, fogging or dust (including pet 

areas) applications indoors excluding metered release devices: 

“Remove or cover exposed food and drinking water before application.”

“Remove or cover dishes, utensils, food processing equipment, and food preparation surfaces, or 

wash them before use.” 

Products labeled for use around or near floor drains. Products labeled for use in drains or 

sewers are excluded from this label requirement: “Do not apply directly into sewers or drains, or 

to any area like a gutter where drainage to storm sewers, water bodies, or aquatic habitat can occur. 

Do not allow the product to enter any drain during or after application.”
20

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

Products labeled for use in drains or sewers:

“Except when applying to sewers or drains as instructed on this label, do not apply directly to 

sewers or drains, or to any area like a gutter where drainage to sewers, storm drains, water bodies, 

or aquatic habitat can occur.”

Residential Outdoor Surface and Space Sprays, except for outdoor fogging devices:

“All outdoor applications must be limited to spot or crack-and-crevice treatments only, except for 

the following permitted uses:

(1) Treatment to soil or vegetation around structures;

(2) Applications to lawns, turf, and other vegetation;

(3) Applications to building foundations, up to a maximum height of 3 feet. 

Other than applications to building foundations, all outdoor applications to impervious surfaces 

such as sidewalks, driveways, patios, porches and structural surfaces (such as windows, doors, and 

eaves) are limited to spot and crack-and-crevice applications, only.”

Environmental hazard 

statements on Liquid 

Concentrate consumer

outdoor products (e.g., 

liquids mixed with water by 

the user for a tank sprayer 

or hose-end attachment)

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. To protect the 

environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or 

surface waters. Applying this product in calm weather when rain is not predicted for the next 24 

hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.

Rinsing application equipment over the treated area will help avoid run off to water bodies or 

drainage systems.

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental Hazard 

Statement

Environmental hazard 

statements on Dusts 

consumer outdoor products 

(e.g., for garden or 

ornamental)

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. To protect the 

environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or 

surface waters. Applying this product in calm weather when rain is not predicted for the next 24 

hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

Environmental Hazard 

Statement
21

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental hazard 

statements on Ready-toUse consumer outdoor 

products (except aerosols 

and foggers)

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. To protect the 

environment, do not allow pesticide to enter or run off into storm drains, drainage ditches, gutters or 

surface waters. Applying this product in calm weather when rain is not predicted for the next 24 

hours will help to ensure that wind or rain does not blow or wash pesticide off the treatment area.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental Hazard 

Statement

Environmental Hazard 

Statements aerosol and 

fogger consumer outdoor 

products

“This pesticide is toxic to aquatic organisms, including fish and invertebrates. Do not apply directly 

to or near water. Drift and run-off may be hazardous to fish in water adjacent to treated areas. Do 

not contaminate water when disposing of equipment, washwater, or rinsate. See Directions for Use 

for additional precautions and requirements.”

“This product is highly toxic to bees exposed to direct treatment on blooming crops or weeds. Do 

not apply this product or allow it to drift to blooming crops or weeds while bees are actively visiting 

the treatment area.”

Environmental Hazard 

Statement

Residential Use Restriction

(Note: The maximum 

allowable application rate 

and maximum allowable 

seasonal rate must be listed 

as pounds or gallons of 

formulated product per acre 

or per square feet or per 

cubic feet, not just as 

pounds active ingredient per 

unit area.)

Except as noted below, the following rate changes apply only to MGK.

PBO Changes:

The maximum PBO rate for indoor crack and crevice spray is 0.56 lbs ai/1000 square feet.

The maximum space spray rate for post-harvest application to fruits, vegetables, and nuts is 0.01 lbs 

PBO per 1000 cubic feet.

Formulated indoor space spray products eligible for reregistration must not contain more than 0.05 

lbs PBO/16 ounce can.

Directions for Use 

under Use Restrictions
22

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

Formulated pet spray products eligible for reregistration must not contain more than 10 % piperonyl 

butoxide. 

Pyrethrins Changes:

The maximum space spray rate for post-harvest applications to fruits, vegetables and copra is 0.001 

lbs pyrethrins per 1000 cubic feet. 

The maximum space spray rate for residential areas is 0.00033 lbs pyrethrins per 1000 cubic feet.

Formulated pet spray products eligible for reregistration must not contain more than 0.2 % 

pyrethrins. 

All other Pyrethrins and PBO rate changes are included in Appendix A.

Note to Registrant: In addition, these label statements should be deleted from all products 

registered for food handling and processing facilities: 

“Except in Federally inspected meat and poultry plants, food processing operations may 

continue when the product is applied as a general surface spray/crack and crevice spray with 

care and in accordance with the directions and precautions on the label, at a maximum rate of 

X pounds of product per 1000 square feet.” 

MGK Rate Changes:

Trigger Pump Sprayers 

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

All trigger pump sprayers - 0.1 lbs ai/1000 square feet (maximum concentration is 0.5 % ai)

Indoor Aerosol Space Sprays (Residential Areas)
23

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

All aerosol pump sprayers used in residential areas- 0.00015 lbs ai/1000 cubic foot

Non-food (ornamentals, flowering, and foliage plants) plants in Commercial Greenhouses 

Maximum application rates:

Greenhouse surface spray – 0.01 lbs per 1000 square feet 

Greenhouse space sprays - 0.001 lbs ai/1000 cubic feet

Use restrictions:

“Do not apply more than 1 time per day.”

Direct Application to Non-domestic Animals (non-food livestock only, i.e. donkeys, horses, 

ponies, mules)

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Application to non-food livestock– 0.00025 lbs ai/animal (or 2 oz of 0.2% spray/animal) 

Ready-to-use paste applications to horses – 0.0056 lbs ai/horse 

Use restrictions:

“Do not apply more than 1 time per day.”

Indoor Agricultural Premises and Commercial Animal Housing and Equipment (animals not 

present)

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Crack/crevice or spot– 0.05 lbs ai/1000 square feet 

Surface applications – 0.01 lbs ai/1000 square feet 

Space sprays – 0.001 lbs ai/1000 cubic feet 

Metered release device sprays – 0.002 lbs ai/ 1000 cubic feet per day and 1.77 mg ai/spray 

event 
24

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

Use Restrictions:

“Do not apply more than 1 time per day.”

Indoor Food Handling/Processing Facilities

Products must be formulated to deliver no more than the maximum rate when used according 

to directions:

Surface applications – 0.01 lbs ai/1000 square feet

Crack/crevice or spot – 0.05 lbs ai/1000 square feet

Space sprays– 0.001 lbs ai/1000 cubic feet 

Metered release device space sprays – 0.002 lbs ai/1000 cubic feet/day and 1.77 mg ai/spray 

event 

Use Restrictions:

“Do not apply more than 1 time per day.”

Outdoor Agriculture Premises and Equipment

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Surface applications – 0.01 lbs ai/1000 square feet 

Crack/crevice or spot– 0.05 lbs ai/1000 square feet

Use Restrictions:

“Do not apply more than 1 time per day.”

Pet Care

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

The use directions must not allow more than 0.0028 lbs ai/pet for all pet applications, 

including those listed above.

Use restrictions:

“Do not apply to pets less than 12 weeks old.”
25

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

“Consult a veterinarian before applying this product on medicated, debilitated, aged, pregnant, 

or nursing animals.”

“Sensitivities may occur after using any pesticide product for pets. If signs of sensitivity occur 

bathe your pet with mild soap and rinse with large amounts of water. If signs continue, 

consult a veterinarian immediately.”

Registrant Note: Follow instructions in PR Notice 96-6, Pet Pesticide Product Label 

Statements, for including reapplication restrictions on the end-use product label.

Pet Premise Treatment (pets are not present)

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Surface – 0.01 lbs per 100 square feet

Space spray – 0.001 lbs per 1000 square feet

Outdoor Residential Ornamental and Lawns

Maximum application rates: 

Surface applications – 0.3 lbs ai/A 

User Restrictions:

“Do not apply more than 1 time per day.”

Residential Dwellings and Commercial, Institutional Indoor Sites

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Surface applications –0.01 lbs ai/1000 square feet

Crack/crevice or spot – 0.05 lbs ai/1000 square feet 

Space sprays– 0.001 lbs ai/1000 cubic feet 

Metered release device space sprays (except for residential dwellings which are prohibited)–

0.002 lbs ai/1000 cubic feet/day and 1.77 mg ai/spray event 

Residential Indoor Dust Applications to Carpet and Other Indoor Surfaces
26

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Dust – 0.011 lbs ai/100 square feet

User Restrictions:

“Do not apply more than once a day.”

“Only apply as a spot treatment to areas no greater than 3 feet by 3 feet per room.”

General Outdoor Sites (including non-agricultural rights-of-way, 

commercial/institutional/industrial premises, residential sites, and outdoor eating 

establishments)

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Surface applications – 0.01 lbs ai/1000 square feet

Crack/crevice or spot – 0.05 lbs ai/1000 square feet

Metered release device space sprays (except for residential sites which are prohibited) – 0.002

lbs ai/1000 cubic feet/day and 1.77 mg ai/spray event 

Manholes

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Surface applications to manholes – 0.07 lbs ai per manhole over a length of 200 feet 

Use restrictions:

“Do not apply more than 1 time per day.”

Food Stored in Bags

Products must be formulated to deliver no more than this maximum rate when used according 

to directions:

Space sprays may be made to the surfaces of bags of stored food products at the rate of 0.001 

lbs ai/1000 cubic foot.
27

Description Pyrethrins, PBO, MGK-264 Required Labeling Language Placement on Label

Use restrictions:

“Direct application to food contact surfaces is prohibited.” 

Use-Specific Application 

Restrictions for all liquid 

and wettable powder labels 

(Outdoor residential misting 

system requirement)

(Note: The maximum 

allowable application rate 

and maximum allowable 

seasonal rate must be listed 

as pounds or gallons of 

formulated product per acre, 

not just as pounds active 

ingredient per acre.)

Outdoor Residential Misting Systems

Products not intended for use in outdoor residential misting systems must contain the 

following statement: 

“Not for use in outdoor residential misting systems.”

Directions for Use 

under Use Restrictions

1 PPE that is established on the basis of Acute Toxicity of the end-use product must be compared to the active ingredient PPE in this document. In the case of multiple 

active ingredients, the more protective PPE must be placed on the product labeling. For guidance on which PPE is considered more protective, see PR Notice 93-7.