Exhibit 2.10



SYNDICATION AND AMENDMENT AGREEMENT

dated 25 September 2007

between

QIAGEN N.V.

as Company

QIAGEN N.V.

QIAGEN DEUTSCHLAND HOLDING GMBH

QIAGEN NORTH AMERICAN HOLDINGS, INC.

QIAGEN SCIENCES INC.

as Original Borrowers

DEUTSCHE BANK LUXEMBOURG S.A.

as Existing Lender

THE FINANCIAL INSTITUTIONS LISTED HEREIN

as New Lenders,

and

DEUTSCHE BANK LUXEMBOURG S.A.

acting as Agent

RELATING TO A FACILITIES AGREEMENT

dated 13 July 2007

arranged by

DEUTSCHE BANK AG

WHITE & CASELLP

QiagenSyndication and Amendment Agreement

Dokument: 1105332_9 [FRANKFURT]



---

THIS AGREEMENT is dated 25 September 2007 and made between:



|(1) | QIAGEN N.V. as borrower and guarantor (the Company);
|--- | ------------------------------------------------------



|(2) | QIAGEN N.V., QIAGEN DEUTSCHLAND HOLDING GMBH, QIAGEN NORTH AMERICAN HOLDINGS, INC. and QIAGEN SCIENCES INC.as original borrowers (the Original Borrowers);
|--- | ------------------------------------------------------------------------------------------------------------------------------------------------------------



|(3) | DEUTSCHE BANK AG (the Mandated Lead Arranger);
|--- | ------------------------------------------------



|(4) | DEUTSCHE BANK LUXEMBOURG S.A. as existing Lender (the Existing Lender);
|--- | -------------------------------------------------------------------------



|(5) | THE FINANCIAL INSTITUTIONS listed in Schedule-1 as new Lenders (the New Lenders); and
|--- | ---------------------------------------------------------------------------------------



|(6) | DEUTSCHE BANK LUXEMBOURG S.A.as facility agent (the Agent).
|--- | -------------------------------------------------------------

IT IS AGREEDas follows:



|1. | DEFINITIONS AND INTERPRETATION
|-- | ------------------------------



|1.1 | Definitions
|--- | -----------

In this Agreement:

Amended Agreement means the Original Facility Agreement, as amended by this Agreement.

Original Facility Agreement means the EUR 750,000,000 Syndicated Multi-Currency Term Loan and Revolving Credit Facilities Agreement
dated 13 July 2007 between the Company, the Original Borrowers, the Mandated Lead Arranger, the Existing Lender and the Agent.

Syndication Date means 27 September 2007 or any other date as specified by the Agent.



|1.2 | Incorporation of defined terms
|--- | ------------------------------

(a) Unless a
contrary indication appears, a term defined in the Original Facility Agreement has the same meaning in this Agreement.

(b) The principles
of construction set out in the Original Facility Agreement shall have effect as if set out in this Agreement.



|1.3 | Clauses
|--- | -------

In this Agreement any reference to a
Clause or a Schedule is, unless the context otherwise requires, a reference to a Clause of or a Schedule to this Agreement.



|1.4 | Designation
|--- | -----------

In accordance with the Original
Facility Agreement, each of the Company and the Agent designate this Agreement as a Finance Document.



|2. | REPRESENTATIONS
|-- | ---------------

Each Obligor makes the
Representations as set out in Clause 16.24 (Repetition of Representation and Warranties)of the Original Facility Agreement by reference to the facts and circumstances then existing:

(a) on the date of this Agreement; and

(b)
on the Syndication Date.



QiagenSyndication and Amendment
Agreement

Dokument: 1105332_9 [FRANKFURT]



2



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|3. | TRANSFER BY ASSUMPTION (VERTRAGSÜBERNAHME)
|-- | ------------------------------------------



|3.1 | Transfer by assumption
|--- | ----------------------

On the Syndication Date
(whether or not a Default is continuing) the Existing Lender shall transfer by assumption (Vertragsübernahme)all or part of its Commitment, rights and obligations under the Original Facility Agreement to a New Lender, so that:



| | (a) | each New Lender will become a Lender under the Amended Agreement with a Facility A Commitment and Facility C Commitment as set out in the relevant columns opposite its name in
Schedule 2 (The Lenders);
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (b) | the Existing Lenders Facility A Commitment and Facility C Commitment shall be reduced to the respective amount set out in the relevant, columns opposite its name in Schedule 2
(The Lenders);
| | --- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (c) | each New Lender will become a Lender under the Amended Agreement with a participation in each Advance as notified to it by the Agent pursuant to paragraphs (a) and (c) of
Clause 3.5 (Lenders participations);and
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (d) | the Existing Lenders participation in each Advance shall be as notified to it by the Agent pursuant to paragraphs (a) and (c) of Clause 3.5 (Lenders
participations).
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------



|3.2 | Procedure for transfer by assumption
|--- | ------------------------------------

The transfer
by assumption set out in Clause 3.1 (Transfer by assumption)shall take effect on the Syndication Date so that:



| | (a) | to the extent that in Clause 3.1 (Transfer by assumption)the Existing Lender seeks to transfer by assumption its rights and obligations under the Original Facility
Agreement, each of the Obligors and the Existing Lender shall be released from further obligations towards one another under the Finance Documents and their respective rights against one another shall be cancelled (being the Discharged
Rights and Obligations);
| | --- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (b) | each of the Obligors and each New Lender shall assume obligations towards one another and/or acquire rights against one another which differ from the Discharged Rights and
Obligations only insofar as that Obligor and the relevant New Lender have assumed and/or acquired the same in place of that Obligor and the Existing Lender;
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (c) | the Agent, the Mandated Lead Arranger and each New Lender shall acquire the same rights and assume the same obligations between themselves as they would have acquired and assumed
had each New Lender been an original Lender with the rights and/or obligations acquired or assumed by it as a result of the transfer by assumption and to that extent the Agent, the Mandated Lead Arranger, and the Existing Lender shall each be
released from further obligations to each other under the Finance Documents; and
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (d) | each New Lender shall become a party as a Lender.
| | --- | ---------------------------------------------------



|3.3 | Limitation of responsibility of Existing Lender
|--- | -----------------------------------------------



| | (a) | Unless expressly agreed to the contrary, the Existing Lender make no representation or warranty and assume no responsibility to the New Lenders for:
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------



| | (i) | the legality, validity, effectiveness, adequacy or enforceability of the Transaction Documents or any other documents;
| | --- | ----------------------------------------------------------------------------------------------------------------------



| | (ii) | the financial condition of any Obligor;
| | ---- | ---------------------------------------



QiagenSyndication and Amendment Agreement

Dokument: 1105332_9 [FRANKFURT]



3



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| | (iii) | the performance and observance by any Obligor of its obligations under the Transaction Documents or any other documents; or
| | ----- | ---------------------------------------------------------------------------------------------------------------------------



| | (iv) | the accuracy of any statements (whether written or oral) made in or in connection with any Transaction Document or any other document,
| | ---- | --------------------------------------------------------------------------------------------------------------------------------------

and any representations or warranties implied by law are excluded.



| | (b) | Each New Lender confirms that it:
| | --- | ---------------------------------



| | (i) | has received a copy of the Original Facility Agreement together with such other information as it has required in connection with this transaction;
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------



| | (ii) | has made (and shall continue to make) its own independent investigation and assessment of the financial condition and affairs of each Obligor and its related entities in connection
with its participation in this Agreement and the Amended Agreement and has not relied exclusively on any information provided to it by the Existing Lender in connection with any Transaction Document; and
| | ---- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (iii) | will continue to make its own independent approval of the creditworthiness of each Obligor and its related entities whilst any amount is or may be outstanding under the Transaction
Documents or any Commitment is in force.
| | ----- | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (c) | Nothing in any Finance Document obliges the Existing Lender to:
| | --- | ---------------------------------------------------------------



| | (i) | accept a re-transfer from any New Lender of any of the rights and obligations transferred by assumption under this Agreement; or
| | --- | --------------------------------------------------------------------------------------------------------------------------------



| | (ii) | support any losses directly or indirectly incurred by a New Lender by reason of the non-performance by any Obligor of its obligations under the Finance Documents or otherwise.
| | ---- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|3.4 | Administrative Details
|--- | ----------------------

Each New Lender has
delivered to the Agent its Facility Office details and address, fax number and attention details for the purposes of Clause 34 (Notices)of the Amended Agreement.



|3.5 | Lenders participations
|--- | -----------------------



| | (a) | The Agent shall notify the Existing Lender and each New Lender of the amount and currency of each Facility C Advance requested, pursuant to a Utilisation Request, to be made on the
Syndication Date and the amount of its participation in that new Advance no later than 11:00 a.m. on the Syndication Date.
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (b) | The Existing Lender and each New Lender shall make its participation in each Advance referred to in paragraph (a) above available on the Syndication Date.
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------



| | (c) | The Agent shall notify each New Lender and the Existing Lender of the amount and currency of each Facility A Advance and each Facility C Advance which was made before the
Syndication Date and which is to continue to be outstanding on the Syndication Date and the amount and currency of its participation in that Facility A Advance and Facility C Advance, on the Syndication Date.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| | (d) | The Agent shall notify each New Lender of the Interest Periods commencing on the Syndication Date pursuant to the relevant Interest Selection Notices, at least two days prior to the
Syndication Date.
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



QiagenSyndication and
Amendment Agreement

Dokument: 1105332_9 [FRANKFURT]



4



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|4. | CONDITIONS PRECEDENT
|-- | --------------------

The Agent hereby confirms to the New Lenders
that it has received all documents and other evidence listed in Schedule 3 (Conditions Precedent)of the Original Facility Agreement, each in form and substance satisfactory to the Agent as provided in Clause 3,1 (Initial Conditions
Precedent)of the Original Facility Agreement. The Agent further confirms that it has notified the Company and the Existing Lender in accordance with paragraph b) of Clause 3.1 (Initial Conditions Precedent)of the Original Facility
Agreement.



|5. | AMENDMENTS
|-- | ----------



|5.1 | Amendments
|--- | ----------

With effect from the Syndication Date
the Original Facility Agreement shall be amended as set out in Schedule 3 (Amendments to Original Facility Agreement).



|5.2 | Quotation Date
|--- | --------------

The parties agree that for the
purposes of any Facility C Advance to be made on the Syndication Date, the Quotation Date shall be the Syndication Date.



|5.3 | Continuing obligations
|--- | ----------------------

The provisions of the
Original Facility Agreement and the other Finance Documents shall, save as amended by this Agreement, continue in full force and effect.



|6. | CONSENTS AND WAIVERS
|-- | --------------------



|6.1 | Consent and Waiver
|--- | ------------------

The Company, the Original
Borrowers and the Guarantor, the Mandated Lead Arranger, the Existing Lender and the Agent:



| | (a) | consent to the New Lenders becoming Lenders; and
| | --- | ------------------------------------------------



| | (b) | waive the requirements of paragraph c) of Clause 30.3 (Assignments or Transfers by Lenders)and Clauses 30.4 (Procedure of Transfer)of the Original Facility Agreement
for the purposes of this Agreement and for the transfer by assumption effected pursuant to this Agreement.
| | --- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



|6.2 | Agents Waiver
|--- | --------------

The Agent waives the
requirement for the payment of the fee referred to in paragraph d) of Clause 30.3 (Assignments or Transfers by Lenders)of the Original Facility Agreement in respect of the transfers by assumption effected pursuant to this Agreement.



|7. | MISCELLANEOUS
|-- | -------------



|7.1 | Incorporation of terms
|--- | ----------------------

The provisions of Clause 34
(Notices)and Clause 37 (Governing Law and Jurisdiction)of the Original Facility Agreement shall be incorporated into this Agreement as if set out in full in this Agreement and as if references in those clauses to this
Agreement are references to this Agreement and as if references in those clauses to Lender include the New Lenders.



|7.2 | Counterparts
|--- | ------------

This Agreement may be executed in any
number of counterparts, and this has the same effect as if the signatures on the counterparts were on a single copy of this Agreement.

This Agreement has
been entered into on the date stated at the beginning of this Agreement.



QiagenSyndication and Amendment Agreement

Dokument: 1105332_9 [FRANKFURT]



5



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SCHEDULE 1

The New Lenders



|    |  |                                                                
|--- |  | ---------------------------------------------------------------
|1.  |  | Banque LB Lux S.A.                                             
|2.  |  | Commerzbank AG                                                 
|3.  |  | Deutsche Apotheker-und Ärztebank                               
|4.  |  | Deutsche Postbank International S.A.                           
|5.  |  | DZ Bank Deutsche Zentral-Genossenschaftsbank, Frankfurt am Main
|6.  |  | Goldman Sachs Credit Partners L.P.                             
|7.  |  | 1KB Deutsche Industriebank AG, Filiale Luxemburg               
|8.  |  | KfW                                                            
|9.  |  | Sal. Oppenheim jr. & Cie. KGaA                                 
|10. |  | Stadtsparkasse Düsseldorf                                      
|11. |  | The Bank of Tokyo-Mitsubishi UFJ, Ltd. Düsseldorf Branch       
|12. |  | The Royal Bank of Scotland plc, Niederlassung Frankfurt        
|13. |  | West LB AG                                                     
|14. |  | WGZ BankAG-Westdeutsche Genossenschafts-Zentralbank            



QiagenSyndication
and Amendment Agreement

Dokument: 1105332_9 [FRANKFURT]



6



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SCHEDULE 2

The Lenders



|    |  |                                                                 |  |                         |  |                                           |  |                        
|--- |  | --------------------------------------------------------------- |  | ----------------------- |  | ----------------------------------------- |  | -----------------------
|    |  | Name of Lender                                                  |  | Facility ACommitmentUSD |  | Participation inFacility AOutstanding USD |  | Facility CCommitmentUSD
|1.  |  | Banque LB Lux S.A.                                              |  | 40,769,230.77           |  | 40,769,230.77                             |  | 12,230,769.23          
|2.  |  | Commerzbank AG                                                  |  | 40,769,230.77           |  | 40,769,230.77                             |  | 12,230,769.23          
|3.  |  | Deutsche Apotheker-und Ärztebank                                |  | 20,000,000.00           |  | 20,000,000.00                             |  | 6,000,000.00           
|4.  |  | Deutsche Bank Luxembourg S.A.                                   |  | 54,615,384.62           |  | 54,615,384.62                             |  | 16,384,615.38          
|5.  |  | Deutsche Postbank International S.A.                            |  | 20,000,000.00           |  | 20,000,000.00                             |  | 6,000,000.00           
|6.  |  | DZ Bank Deutsche Zentral-Genossenschaftsbank, Frankfurt am Main |  | 40,769,230.77           |  | 40,769,230.77                             |  | 12,230,769.23          
|7.  |  | Goldman Sachs Credit Partners L.P.                              |  | 40,769,230.77           |  | 40,769,230.77                             |  | 12,230,769.23          
|8.  |  | 1KB Deutsche Industriebank AG, Filiale Luxemburg                |  | 40,769,230.77           |  | 40,769,230.77                             |  | 12,230,769.23          
|9.  |  | KfW                                                             |  | 20,000,000.00           |  | 20,000,000.00                             |  | 6,000,000.00           
|10. |  | Sal. Oppenheim jr. & Cie. KGaA                                  |  | 20,000,000.00           |  | 20,000,000.00                             |  | 6,000,000.00           
|11. |  | Stadtsparkasse Düsseldorf                                       |  | 20,000,000.00           |  | 20,000,000.00                             |  | 6,000,000.00           
|12. |  | The Bank of Tokyo-Mitsubishi UFJ, Ltd. Düsseldorf Branch        |  | 20,000,000.00           |  | 20,000,000.00                             |  | 6,000,000.00           
|13. |  | The Royal Bank of Scotland plc, Niederlassung Frankfurt         |  | 50,769,230.77           |  | 50,769,230.77                             |  | 15,230,769.23          
|14. |  | West LB AG                                                      |  | 50,769,230.77           |  | 50,769,230.77                             |  | 15,230,769.23          
|15. |  | WGZ Bank AGWestdeutsche Genossenschafts-Zentralbank            |  | 20,000,000.00           |  | 20,000,000.00                             |  | 6,000,000.00           
|    |  | TOTAL                                                           |  | 500,000,000.00          |  | 500,000,000.00                            |  | 150,000,000.00         

QiagenSyndication and Amendment Agreement

Dokument: 1105332_9 [FRANKFURT]



7



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SCHEDULE 3

Amendments to Original Facility Agreement



|1. | The following definitions of Clause 1.1 (Definitions) shall be deleted and replaced by the following definitions:
|-- | -----------------------------------------------------------------------------------------------------------------

Merger means the merger of Digene Corporation with and into Energy Merger Sub, Inc. as surviving entity which was after the merger
renamed to Digene Corporation.

Target means Digene Corporation.



|2. | Paragraph (viii) of Clause 19.11 (Restrictions on Financial Indebtedness) shall be renumerated as paragraph (ix) and a new paragraph (viii) shall be included as
follows:
|-- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------

(viii) arising under a sale-and-lease-back programme of certain Logistic Center equipment of
Qiagen GmbH, provided that the aggregate capital value of all such items so leased by members of the Group does not exceed EUR 2,500,000 in aggregate; and.



|3. | The first sentence in Clause 2 (Total Interest Cover)of Schedule 5 (Financial Covenants)shall be deleted and replaced by the following sentence:
|-- | ------------------------------------------------------------------------------------------------------------------------------------------------

In respect of any Testing Period, Total Interest Cover on each date specified in Column 1 below is more than the ratio
specified in Column 2 below opposite such date:.

QiagenSyndication and Amendment Agreement

Dokument: 1105332_9 [FRANKFURT]



8



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SIGNATURES

The
Company

QIAGEN N.V.



|                |  |                    
|--------------- |  | -------------------
|By:             |  | /s/ Peer M. Schatz 
|                | 
|By:             |  | /s/ Roland Sackers 
|                | 
|Address:        |  | Spoorstraat 50     
|                |  | KJ 5911 Venlo      
|                |  | The Netherlands    
|                | 
|Tel:            |  | +49 2103 2911707   
|                | 
|Fax:            |  | +49 2103 2921707   
|                | 
|Attention:      |  | Peer M. Schatz, CEO
|                | 
|                |  | Roland Sackers, CFO
|                | 
|With a copy to: |  |                    
|                | 
|                |  | QIAGEN GmbH        
|                | 
|Address:        |  | Qiagen Str. 1      
|                |  | 40724 Hilden       
|                |  | Germany            
|                | 
|Tel:            |  | +49 2103 2911844   
|                | 
|Fax:            |  | +49 2103 2921844   
|                | 
|Attention:      |  | Legal Counsel      

QiagenSyndication and Amendment Agreement



9



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The Original Borrowers

QIAGEN N.V.



|                |  |                    
|--------------- |  | -------------------
|By:             |  | /s/ Peer M. Schatz 
|                | 
|By:             |  | /s/ Roland Sackers 
|                | 
|Address:        |  | Spoorstraat 50     
|                |  | KJ 5911 Venlo      
|                |  | The Netherlands    
|                | 
|Tel:            |  | +49 2103 2911707   
|                | 
|Fax:            |  | +49 2103 2921707   
|                | 
|Attention:      |  | Peer M. Schatz, CEO
|                | 
|                |  | Roland Sackers, CFO
|                | 
|With a copy to: |  |                    
|                | 
|                |  | QIAGEN GmbH        
|                | 
|Address:        |  | Qiagen Str. 1      
|                |  | 40724 Hilden       
|                |  | Germany            
|                | 
|Tel:            |  | +49 2103 2911844   
|                | 
|Fax:            |  | +49 2103 2921844   
|                | 
|Attention:      |  | Legal Counsel      

QiagenSyndication and Amendment Agreement



10



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QIAGEN DEUTSCHLAND HOLDING GMBH



|                |  |                    
|--------------- |  | -------------------
|By:             |  | /s/ Peer M. Schatz 
|                | 
|By:             |  | /s/ Roland Sackers 
|                | 
|Address:        |  | Qiagen Str. 1      
|                |  | 40724 Hilden       
|                |  | Germany            
|                | 
|Tel:            |  | +49 2103 2911707   
|                | 
|Fax:            |  | +49 2103 2921707   
|                | 
|Attention:      |  | Peer M. Schatz, CEO
|                | 
|                |  | Roland Backers, CFO
|                | 
|With a copy to: |  |                    
|                | 
|                |  | QIAGEN GmbH        
|                | 
|Address:        |  | Qiagen Str. 1      
|                |  | 40724 Hilden       
|                |  | Germany            
|                | 
|Tel:            |  | +49 210 32911844   
|                | 
|Fax:            |  | +49 210 32921844   
|                | 
|Attention:      |  | Legal Counsel      

QiagenSyndication and Amendment Agreement



11



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QIAGEN NORTH AMERICAN HOLDINGS, INC.



|                |  |                     
|--------------- |  | --------------------
|By:             |  | /s/ Peer M. Schatz  
|                | 
|By:             |  | /s/ Roland Sackers  
|                | 
|Address:        |  | 9300 Germantown Road
|                |  | Germantown          
|                |  | MD 20874            
|                |  | USA                 
|                | 
|Tel:            |  | +1 (240) 686 7772   
|                | 
|Fax:            |  | +1 (240) 686 7773   
|                | 
|Attention:      |  | Peer M. Schatz, CEO 
|                | 
|                |  | Roland Sackers, CFO 
|                | 
|With a copy to: |  |                     
|                | 
|                |  | QIAGEN GmbH         
|                | 
|Address:        |  | Qiagen Str. 1       
|                |  | 40724 Hilden        
|                |  | Germany             
|                | 
|Tel:            |  | +49 2103 2911844    
|                | 
|Fax:            |  | +49 2103 2921844    
|                | 
|Attention:      |  | Legal Counsel       

QiagenSyndication and Amendment Agreement



12



---

QIAGEN SCIENCES INC.



|                |  |                     
|--------------- |  | --------------------
|By:             |  | /s/ Peer M. Schatz  
|                | 
|By:             |  | /s/ Roland Sackers  
|                | 
|Address:        |  | 9300 Germantown Road
|                |  | Germantown          
|                |  | MD 20874            
|                |  | USA                 
|                | 
|Tel:            |  | +1 (240) 686 7772   
|                | 
|Fax:            |  | +1 (240) 686 7773   
|                | 
|Attention:      |  | Peer M. Schatz, CEO 
|                | 
|                |  | Roland Sackers, CFO 
|               
|With a copy to:
|                |  | QIAGEN GmbH         
|                | 
|Address:        |  | Qiagen Str. 1       
|                |  | 40724 Hilden        
|                |  | Germany             
|                | 
|Tel:            |  | +49 2103 2911844    
|                | 
|Fax:            |  | +49 2103 2921844    
|                | 
|Attention:      |  | Legal Counsel       

QiagenSyndication and Amendment Agreement



13



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The Guarantor

QIAGEN N.V.



|                |  |                    
|--------------- |  | -------------------
|By:             |  | /s/ Peer M. Schatz 
|                | 
|By:             |  | /s/ Roland Sackers 
|                | 
|Address:        |  | Spoorstraat 50     
|                |  | KJ 5911 Venlo      
|                |  | The Netherlands    
|                | 
|Tel:            |  | +49 2103 2911707   
|                | 
|Fax:            |  | +49 2103 2921707   
|                | 
|Attention:      |  | Peer M. Schatz, CEO
|                | 
|                |  | Roland Sackers, CFO
|               
|With a copy to:
|                |  | QIAGEN GmbH        
|                | 
|Address:        |  | Qiagen Str.1       
|                |  | 40724 Hilden       
|                |  | Germany            
|                | 
|Tel:            |  | +49 2103 2911844   
|                | 
|Fax:            |  | +49 2103 2921844   
|                | 
|Attention:      |  | Legal Counsel      

QiagcnSyndication and Amendment Agreement



14



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The Mandated Lead Arranger

DEUTSCHE BANK AG



|           |  |                                
|---------- |  | -------------------------------
|By:        |  | Illegible                      
|           | 
|Address:   |  | Große Gallusstraße 10-14       
|           |  | D-60311 Frankfurt am Main      
|           |  | Germany                        
|           | 
|Tel:       |  | 49 69 910 36951                
|           | 
|Fax:       |  | 49 69 910 38793                
|           | 
|Attention: |  | Loan Capital Markets/Tina Fuchs

The Agent

DEUTSCHE BANK LUXEMBOURG S.A.



|           |  |                                                     
|---------- |  | ----------------------------------------------------
|By:        |  | Illegible                                           
|           | 
|Address:   |  | 2, boulevard Konard Adenauer                        
|           |  | L-1115 Luxembourg                                   
|           | 
|Tel:       |  | +352 421222 81                                      
|           | 
|Fax:       |  | +352 42122 95771                                    
|           | 
|Attention: |  | International Loan and Agency Services/Nigel Hibberd

The Existing Lender

DEUTSCHE BANK LUXEMBOURG S.A.



|           |  |                                                     
|---------- |  | ----------------------------------------------------
|By:        |  | Illegible                                           
|           | 
|Address:   |  | 2, boulevard Konrad Adenauer                        
|           |  | L-1115 Luxembourg                                   
|           | 
|Tel:       |  | +552 42122 281                                      
|           | 
|Fax:       |  | +352 42122 95771                                    
|           | 
|Attention: |  | International Loan and Agency Services/Nigel Hibberd

QiagenSyndication and Amendment Agreement



15



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The New Lenders

BANQUE LB LUX S.A.



|           |  |                         |  |                     
|---------- |  | ----------------------- |  | --------------------
|           |  |                        
|By:        |  | /s/  Kenneth Andersen   |  | /s/  Kerstin Franzeo
|           |  |                        
|Address:   |  | 3, rue Jean Monnet      |  |                     
|           |  | L2016 Luxembourg       |  |                     
|           |  |                        
|Tel:       |  | +352 42 434 3328 / 3340 |  |                     
|           |  |                        
|Fax:       |  | +352 42 434 3399        |  |                     
|           |  |                        
|Attention: |  | Corporate Finance       |  |                     

COMMERZBANK AG



|           |  |                        
|---------- |  | -----------------------
|By:        |  | Illegible              
|           | 
|Address:   |  | Kaiserplatz            
|           |  | 60311 Frankfurt am Main
|           | 
|Tel:       |  | +49 69 136 29245       
|           | 
|Fax:       |  | +49 69 136 22593       
|           | 
|Attention: |  | Jan Prieshof           

DEUTSCHE APOTHEKER-UND ÄRZTEBANK



|           |  |                                        |  |                      
|---------- |  | -------------------------------------- |  | ---------------------
|By:        |  | /s/  Harald Morsbach                   |  | /s/  Thorsten
Steuber
|           |  |                                       
|Address:   |  | Richard-Oskar-Mattern-Straße 6         |  |                      
|           |  | 40547 Düsseldorf                       |  |                      
|           |  |                                       
|Tel:       |  | +49 211 5998 9389                      |  |                      
|           |  |                                       
|Fax:       |  | +49 211 5998 9388                      |  |                      
|           |  |                                       
|Attention: |  | Firmenkunden and Versorgungsstrukturen |  |                      

QiagenSyndication and Amendment Agreement



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DEUTSCHE POSTBANK INTERNATIONAL S.A.



|           |  |                                                      |  |                 
|---------- |  | ---------------------------------------------------- |  | ----------------
|           |  |                                                     
|By:        |  | /s/  Dr. St. Deoker                                  |  | /s/  P. Laudwein
|           | 
|Address:   |  | 1820, Parc dActivité Syrdall                      
|           |  | L5365 Luxembourg-Munsbach                           |  |                 
|           |  |                                                     
|Tel:       |  | +352 34 95 31 250 / 251                              |  |                 
|           |  |                                                     
|Fax:       |  | +350 34 95 32 666                                    |  |                 
|           | 
|Attention: |  | PB Finance Center/Thomas Pfleger/Klaus Großekathöfer

DZ BANK AG DEUTSCHE ZENTRAL-GENOSSENSCHAFTSBANK, FRANKFURT AM MAIN



|           |  |                                                                                                        
|---------- |  | -------------------------------------------------------------------------------------------------------
|By:        |  | Illegible                                                                                              
|           | 
|Address:   |  | Platz der Republik                                                                                     
|           |  | 60265 Frankfurt am Main                                                                                
|           | 
|Tel:       |  | +49 69 7447 90857 / 6440                                                                               
|           | 
|Fax:       |  | +49 69 7447 99879 / 6645                                                                               
|           | 
|Attention: |  | Acquisition and Leveraged Finance F/SFLF/Dirk
Spangenberg Structured Loans Analysis F/KRSF/Peter Sachse

GOLDMAN SACHS CREDIT PARTNERS L.P.



|           |  |                                
|---------- |  | -------------------------------
|By:        |  | Illegible                      
|           | 
|Address:   |  | c/o Goldman Sachs International
|           |  | Petershill, 1 Carter Lane      
|           |  | London EC4V 5ER                
|           |  | United Kingdom                 
|           | 
|Tel:       |  | +44 20 7552 3881 / 2832        
|           | 
|Fax:       |  | +44 20 7552 7070               
|           | 
|Attention: |  | Caroline Bran/Nicola Laming    

QiagenSyndication and Amendment Agreement



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IKB DEUTSCHE INDUSTRIEBANK AG, FILIALE LUXEMBURG



|           |  |                                        |  |               
|---------- |  | -------------------------------------- |  | --------------
|           |  |                                       
|By:        |  | /s/  Dr.
Werner Winnen                 |  | /s/  Iris Graf
|           |  |                                       
|Address:   |  | 12, rue Erasme                         |  |               
|           |  | L1468 Luxembourg                      |  |               
|           |  |                                       
|Tel:       |  | +352 423 777 400                       |  |               
|           |  |                                       
|Fax:       |  | +352 423 777 442                       |  |               
|           | 
|Attention: |  | Kreditadministration/Dr. Werner Winnen

KFW



|           |  |                                               |  |                   
|---------- |  | --------------------------------------------- |  | ------------------
|           |  |                                              
|By:        |  | /s/  Stetan Wolf First Vice President         |  | /s/  Jutta Roeller
|           |  |                                              
|Address:   |  | Palmengartenstrasse 5-9                       |  |                   
|           |  | 60325 Frankfurt am Main                       |  |                   
|           |  |                                              
|Tel:       |  | +49 69 7431 1711                              |  |                   
|           |  |                                              
|Fax:       |  | +49 69 7431 9609                              |  |                   
|           | 
|Attention: |  | Origination and Structuring/Christoph Seibert

SAL. OPPENHEIM JR. & CIE. KGAA



|           |  |                                          |  |                              
|---------- |  | ---------------------------------------- |  | -----------------------------
|           |  |                                         
|By:        |  | /s/  Theodor Merkl Senior Vice President |  | /s/  Martin Hilleke Associate
|           |  |                                         
|Address:   |  | Unter Sachsenhausen 4                    |  |                              
|           |  | 50667 Köln                               |  |                              
|           |  |                                         
|Tel:       |  | +49 221 145 1714                         |  |                              
|           |  |                                         
|Fax:       |  | +49 221 145 91714                        |  |                              
|           | 
|Attention: |  | Credit Risk Management/Theodor Merkl   

QiagenSyndication and Amendment Agreement



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STADTSPARKASSE DÜSSELDORF



|           |  |                       
|---------- |  | ----------------------
|By:        |  | Illegible             
|           | 
|Address:   |  | Berliner Allee 33,    
|           |  | 40212 Düsseldorf      
|           | 
|Tel:       |  | +49 211 878 1546      
|           | 
|Fax:       |  | +49 211 878 5969      
|           | 
|Attention: |  | Abteilung Firmenkunden

THE BANK OF TOKYO-MITSUBISHI UFJ, LTD., DÜSSELDORF BRANCH



|           |  |                           
|---------- |  | --------------------------
|By:        |  | Illegible                 
|           | 
|Address:   |  | Breite Straße 34          
|           |  | 40213 Düsseldorf          
|           | 
|Tel:       |  | +49 211 3667-480          
|           | 
|Fax:       |  | +49 211 3667-433          
|           | 
|Attention: |  | European Business Division

THE ROYAL BANK OF SCOTLAND PLC, NIEDERLASSUNG FRANKFURT



|           |  |                                     
|---------- |  | ------------------------------------
|By:        |  | Illegible                           
|           | 
|Address:   |  | Junghofstrasse 22                   
|           |  | 60311 Frankfurt am Main             
|           | 
|Tel:       |  | +49 69 17006 404                    
|           | 
|Fax:       |  | +49 69 17006 401                    
|           | 
|Attention: |  | GBM Frankfurt, New Corporate Segment



| |  |                                                     |  |  |  |                                             
| |  | --------------------------------------------------- |  |  |  | --------------------------------------------
| |  | /s/  Frank Borisch                                  |  |  |  | /s/  Florian Von
Bodman                     
| |  | Senior Director Global Banking & Markets Corporates |  |  |  | Director Global Banking & Markets Corporates

QiagenSyndication and Amendment Agreement



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WEST LB AG



|           |  |                                   |  |             
|---------- |  | --------------------------------- |  | ------------
|           |  |                                  
|By:        |  | /s/  C. Uebbing                   |  | /s/  Lotzner
|           | 
|Address:   |  | Herzogstrasse 15 40217 Düsseldorf
|           |  |                                  
|Tel:       |  | +49 021 1826 5801                 |  |             
|           |  |                                  
|Fax:       |  | +49 021 1826 4016                 |  |             
|           |  |                                  
|Attention: |  | 001-56110/Thomas Glahe            |  |             

WGZ BANK AG-WESTDEUTSCHE GENOSSENSCHAFTS-ZENTRALBANK



|           |  |                                                            
|---------- |  | -----------------------------------------------------------
|By:        |  | Illegible                                                  
|           | 
|Address:   |  | Ludwig-Erhard-Allee 20 40227 Düsseldorf                    
|           | 
|Tel:       |  | +49 211 778 2534 / 2114 / 2353                             
|           | 
|Fax:       |  | +49 211 778 2404 / 2198 / 2379                             
|           | 
|Attention: |  | Structured Finance/Captial Market Clients/Corporate Finance

QiagenSyndication and Amendment Agreement



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