U.S. Environmental Protection Agency October 2008 

Hazard-Based Prioritization Draft 

 

SCREENING-LEVEL HAZARD CHARACTERIZATION AND PRIORITIZATION 

ALKYL PHENOLS

8 Chemicals 

HBP Subject Chemicals

CAS Registry Number CA1

 Index Name 

91672-41-2 Phenol, 2-nonyl-, branched 

134701-20-5 Phenol, 2,4-dimethyl-6-(1-methylpentadecyl)- 

233587-36-5 Phenol, 2(or 4)-sec-tetracosyl234446-37-8 Phenol, 2(or 4)-sec-hexacosyl234446-38-9 Phenol, 2(or 4)-sec-octacosyl234446-39-0 Phenol, 2(or 4)-sec-triacontylSupporting Chemicals

CAS Registry Number CA1 Index Name 

89-72-5 Phenol, 2-(1-methylpropyl)- 

84852-15-3 Phenol, 4-nonyl-, branched 

Prepared by 

Office of Pollution Prevention and Toxics 

Environmental Protection Agency 

1200 Pennsylvania Avenue, NW 

Washington, DC 20460-0001 

 

1

 Chemical Abstracts 
U.S. Environmental Protection Agency October 2008 

Hazard-Based Prioritization Draft 

 

SCREENING-LEVEL HAZARD CHARACTERIZATION AND PRIORITIZATION 

DOCUMENT 

Screening-level hazard characterizations for medium production volume chemicals are important 

contributions to the chemicals cooperation work being done in North America2

 through the EPA 

Chemical Assessment and Management Program (ChAMP)3

. This chemical cluster was 

organized to maximize the potential information available to inform screening-level 

prioritization of chemicals needing further consideration and, where possible, to prioritize among 

multiple needs. Although most of the information considered relates to hazard, inferences about 

exposure that can be drawn from existing environmental fate and regulatory information have 

also been used, and information from the 2006 Inventory Update Reporting (IUR)4 is included to 

inform exposure potential when it is available. 

These screening-level hazard characterizations are technical documents intended to support 

subsequent decisions and actions by Office of Pollution Prevention and Toxics (OPPT). They 

provide a vehicle for public access to a concise assessment of the technical data on MPV 

chemicals and provide information previously not readily available to the public. The screeninglevel hazard characterizations, as the name indicates, do not evaluate the potential risks of a 

chemical or cluster of chemicals. This initial prioritization does not constitute a final Agency 

determination. Recommended actions may be considered by EPA in the future based on a 

relative judgment regarding one or more of the chemicals in comparison with others evaluated 

under this program, and in light of the uncertainties presented by gaps in the available data that 

may be determined to exist. 

The purpose of organizing chemicals into structural clusters for this characterization was to 

maximize the number of potential analogs identified for the MPV chemicals, thus maximizing 

the potential data available to inform the MPV hazard characterizations. Organizing each 

chemical and associated data within a cluster will help assessors identify chemical trends, detect 

outlying estimates and measured data, facilitate read across, assist in weight of evidence 

approaches, and support identification of appropriate sub clustering. During the review of each 

cluster, assessors will likely determine endpoint specific subclasses depicting sets of compounds 

with potentially similar mechanistic or biological properties within the larger structural cluster. 

These endpoint specific sub clusters, breakpoints, and trends will be described within each 

section of the hazard characterization. 

2

 USEPA, U.S. Commitments to North American Chemicals Cooperation: 

http://www.epa.gov/hpv/pubs/general/sppframework.htm. 3

 USEPA, ChAMP information: http://www.epa.gov/champ/. 4

 USEPA, IUR Reporting information: http://www.epa.gov/oppt/iur/index.htm. 
U.S. Environmental Protection Agency October 2008 

Hazard-Based Prioritization Draft 

1. STRUCTURAL CLUSTER JUSTIFICATIONS

The alkyl phenols cluster consists of eight organic compounds containing a phenolic hydroxyl 

group substituted and substituted with branched hydrocarbon chains of at least five carbons. Six 

cluster members contains the hydrocarbon chain para to the hydroxyl group (phenol, 4-nonyl-, 

branched, 84852-15-3; phenol, 2(or 4)-sec-tetracosyl-, 233587-36-5; phenol, 2(or 4)-sechexacosyl-, 234446-37-8; phenol, 2(or 4)-sec-octacosyl, 234446-38-9; phenol, 2(or 4)-sectriacontyl-, 234446-39-0; and phenol, 2,4-dimethyl-6-(1-methylpentadecyl)-, 134701-20-5), 

while two members have this substituent in the ortho position (phenol, 2-(1-methylpropyl)-, 89-

72-5 and phenol, 2-nonyl-, branched, 91672-41-2). One cluster member, phenol, 2,4-dimethyl-6-

(1-methylpentadecyl), 134701-20-5, also contains methyl groups in the 2- and 4-positions. 

The following chemicals were reported in the 2006 IUR as being manufactured in or imported to 

the U.S. and are subject to this prioritization assessment: 

CAS Registry Number CA Index Name 

91672-41-2 Phenol, 2-nonyl-, branched 

134701-20-5 Phenol, 2,4-dimethyl-6-(1-methylpentadecyl)- 

233587-36-5 Phenol, 2(or 4)-sec-tetracosyl234446-37-8 Phenol, 2(or 4)-sec-hexacosyl234446-38-9 Phenol, 2(or 4)-sec-octacosyl234446-39-0 Phenol, 2(or 4)-sec-triacontylA number of the above chemicals have previously been reviewed in EPA’s New Chemicals 

Program. The other chemicals included in this cluster are structural analogs used as supporting 

chemicals to help inform the hazard characterization (HC) and hazard-based prioritization (HBP) 

assessment. 

2. PHYSICAL-CHEMICAL PROPERTIES (Table A)

Limited experimental values are available for the members of this cluster. Members are 

expected to be liquids under standard temperature and pressure conditions. The log of the 

octanol/water partition coefficients (log Kow) range from 3.28 to 3.46 for members with 15 or 

fewer carbons. Estimates for those members with 24 or more carbons, range from 10.4 to 16.2; 

although these values are outside the range of the model used to make the estimates, it can be 

concluded that the log Kow for these chemicals is high. There is also a discernable breakpoint for 

boiling point, vapor pressure, and water solubility. For lower molecular weight cluster members, 

the boiling points range from 224 to 310oC and the vapor pressures from 0.000046 to 0.023 hPa. 

The water solubility is moderate for these members. For higher molecular weight members, the 

boiling points range from 420 to 560oC and the vapor pressures from 4.1 ×10-13 to 2.4 ×10-8 hPa. 

The water solubility is negligible for these cluster members. Estimated and experimental pKas 

are in a relatively narrow range of 11 to 12 for all members of this cluster. 
U.S. Environmental Protection Agency October 2008 

Hazard-Based Prioritization Draft 

 

3. ENVIRONMENTAL FATE (Table A)

One member of this cluster, phenol, 2-(1-methylpropyl)- (89-72-5), is expected to have moderate 

mobility in soil and the others are expected to have low mobility. Although estimated Henry’s 

Law Constants suggest volatilization of the alkylphenols from water is moderate, volatilization 

will be mitigated by the presence of suspended solids and the chemicals tendency to partition to 

organic carbon. The rate of atmospheric photooxidation for members of this cluster is 

considered moderate; however, fugacity modeling indicates that phenol, 2-(1-methylpropyl)- 

(89-72-5) will partition predominately to soil and water and to a lesser extent air and that the 

remaining members will partition primarily to soil and sediment. The members of this cluster 

are not expected to hydrolyze. Estimates indicate that that all members of this cluster have the 

potential to biodegrade aerobically under environmental conditions, although experimental and 

estimated data indicate that members will not be readily biodegradable. The alkylphenols in this 

cluster vary in their degree of branching which can affect the degree and rate of biodegradation. 

Therefore, although the cluster members are expected to have low persistence, some may be 

moderately persistent. Bioaccumulation potential is estimated to be low for all members of the 

cluster. 

4. AQUATIC ORGANISM TOXICITY (Table B)

All members of this cluster fall in the ECOSAR phenols class. Experimental data for phenol, 2-

(1-methylpropyl)- (89-72-5) indicates moderate acute toxicity to aquatic invertebrates. 

Experimental data for phenol, 4-nonyl-, branched (84852-15-3) indicates moderate acute toxicity 

to fish and a high acute toxicity to aquatic invertebrates and algae. Estimated data for phenol, 2-

nonyl-, branched (91672-41-2) indicates high acute toxicity to fish and aquatic invertebrates and 

moderate acute toxicity to algae. Chronic toxicity for cluster members with log Kow values < 6 

is estimated to be high for fish, moderate to high for aquatic invertebrates, and moderate for 

algae. Experimental data for phenol, 4-nonyl-branched corroborates the estimates of high 

chronic hazard potential for fish. Cluster members with estimated log Kow values > 10 are 

estimated not to cause acute or chronic effects at saturation based on their very low water 

solubility. 

5. HUMAN HEALTH TOXICITY (Table C)

The majority of the data for assessing the mammalian toxicity of this cluster are for the 

supporting chemicals, phenol, 2-(1-methylpropyl)- (89-72-5) and phenol, 4-nonyl-, branched 

(84852-15-3). Acute toxicity of the supporting chemicals following oral exposure (multiple 

studies available) is moderate to low. Available data for the supporting chemical, phenol, 2-(1-

methylpropyl)- (89-72-5), also indicates low acute toxicity following dermal exposure and 

moderate acute toxicity following inhalation exposure (study summaries can be found in the 

HPV Hazard Characterization for the Alkylphenols Category5

). Additional acute toxicity data 

(oral and dermal in rats) submitted to EPA for a member of this cluster indicates low toxicity; 

however, identifying the chemical and the submission in which the data were provided may be 

5 www.epa.gov/ChAMP
U.S. Environmental Protection Agency October 2008 

Hazard-Based Prioritization Draft 

confidential business information (CBI) and therefore the data are not provided in Table C. 

Repeated oral dose studies for phenol, 4-nonyl-, branched (84852-15-3) and phenol, 2,4-

dimethyl-6-(1-methylpentadecyl)- (134701-20-5) in rats also indicate moderate to low hazard 

potential for the cluster. Additional repeated-dose data (oral exposure in rats) submitted to EPA 

for a member of this cluster indicates moderate toxicity; however, identifying the chemical and 

the submission in which the data were provided may be confidential business information (CBI) 

and therefore the data are not provided in Table C. In a reproductive toxicity study in which rats 

were exposed orally to phenol, 4-nonyl-, branched (84852-15-3), reproductive effects occurred at 

doses indicating moderate hazard. A prenatal developmental toxicity study, also conducted with 

phenol, 4-nonyl-, branched (84852-15-3), showed low maternal systemic toxicity and no 

developmental effects. Data for two cluster members show eye and skin irritation in rabbits, but 

negative skin sensitization in guinea pigs. Additional data submitted to EPA for a member of 

this cluster indicates potential skin irritation and mild but transient eye irritation in rabbits. Data 

for this chemical also indicates it causes skin sensitization in guinea pigs; however, identifying 

the chemical and the submission in which the data were provided may be CBI and therefore the 

data are not provided in Table C. In vitro mutation assays conducted with phenol, 2-(1-

methylpropyl)- (89-72-5) and phenol, 4-nonyl-, branched (84852-15-3) produced negative results 

in Salmonella typhimurium, E. coli, and V79 Chinese hamster cells. Phenol, 4-nonyl-, branched 

(84852-15-3) did not cause chromosome aberrations in vivo. Additional data submitted to EPA 

for a member of this cluster showed negative results for genotoxicity in a reverse mutation assay 

conducted with Salmonella typhimurium and E. coli both with and without activation; however, 

identifying the chemical and the submission in which the data were provided may be CBI and 

therefore the data are not provided in Table C. OncoLogic predicts a low potential for 

carcinogenicity for all members of this cluster. 

6. OVERALL HAZARD CHARACTERIZATION SUMMARY (Table D)

o Persistence and Bioaccumulation: Available experimental and estimated data indicate 

persistence is low for the members of this cluster. Experimental and estimated data for seven 

members of the cluster indicate that bioaccumulation potential is low. 

o Environment: Available experimental and estimated data indicate that the overall acute and 

chronic aquatic toxicity of the alkylphenols cluster is moderate to high for members with log 

Kow values < 6. Members with estimated log Kow values > 10 are predicted to have no effects 

at saturation. 

o Human Health: Available experimental data indicate a low to moderate hazard potential for 

acute and repeated-dose toxicity. Data for phenol, 4-nonyl-, branched (84852-15-3) indicates 

a low potential for prenatal developmental toxicity and a moderate potential for reproductive 

toxicity. The cluster members are expected to cause skin and eye irritation. At least one 

cluster member is a skin sensitizer, but two are not. Experimental studies indicate that 

members of this cluster are not likely to be genotoxic. Members of this cluster are not 

predicted to be carcinogenic. 
U.S. Environmental Protection Agency October 2008 

Hazard-Based Prioritization Draft 

 

7. 2006 NON-CBI IUR INFORMATION

Phenol, 2,4-dimethyl-6-(1-methylpentadecyl)- (134701-20-5); phenol, 2-nonyl-, branched 

(91672-41-2): According to the 2006 Inventory Update Rule (IUR) submissions6, these 

chemicals had aggregated production and/or import volume(s) in the United States between 

10,000 and 500,000 pounds. No industrial processing and uses were reported in the IUR 

submissions for these chemicals. Additionally, no commercial and consumer uses were reported 

in the IUR submissions for these chemicals. 

Phenol, 2(or 4)-sec-tetracosyl-( 233587-36-5): According to the 2006 IUR submissions, this 

chemical had aggregated production and/or import volume(s) in the United States between 

500,000 and 1 million pounds. Industrial processing and uses reported in IUR submissions for 

this chemical were claimed confidential. No commercial and consumer uses were reported in the 

IUR submissions for this chemical. 

Phenol, 2(or 4)-sec-hexacosyl- (234446-37-8): According to the 2006 IUR submissions, this 

chemical had aggregated production and/or import volume(s) in the United States between 

10,000 and 500,000 pounds. Industrial processing and uses reported in IUR submissions for this 

chemical were claimed confidential. No commercial and consumer uses were reported in the 

IUR submissions for this chemical. 

Phenol, 2(or 4)-sec-triacontyl- (234446-39-0); phenol, 2(or 4)-sec-octacosyl- (234446-38-9): 

According to the 2006 IUR submissions, each of these chemicals had aggregated production 

and/or import volume(s) in the United States between 10,000 and 500,000 pounds. No industrial 

processing and uses were reported in the IUR submissions for these chemicals. Additionally, no 

commercial and consumer uses were reported in the IUR submissions for these chemicals. 

8. REGULATORY AND RELATED INFORMATION SUMMARY 

• All cluster members are listed on the TSCA Inventory. Five cluster members (134701-20-5, 

233587-36-5, 234446-37-8, 234446-38-9 and 234446-39-0) are commenced premanufacture 

notification (PMN) substances indicating that their potential risks, based on specified uses, 

have been previously assessed by EPA’s New Chemicals Program. One cluster member 

(134701-20-5) is also subject to a proposed TSCA section 5(a)(2) significant new use rule 

(SNUR). 

• One cluster member (89-72-5) has had exposure limits recommended by NIOSH (REL) and 

ACGIH (TLV).

• EPA’s New Chemicals Program has identified “phenols” as a category with a hazard concern 

of potential ecotoxicity for phenols with log Kows below 7.4 (acute) and ~9 (chronic). 

 

 

6

 USEPA, 2006 Partial Updating of TSCA Chemical Inventory. 
U.S. Environmental Protection Agency October 2008 

Hazard-Based Prioritization Draft 

9. INITIAL PRIORITIZATION DECISION FOR: 

CAS Registry Number CA Index Name 

91672-41-2 Phenol, 2-nonyl-, branched 

134701-20-5 Phenol, 2,4-dimethyl-6-(1-methylpentadecyl)- 

233587-36-5 Phenol, 2(or 4)-sec-tetracosyl234446-37-8 Phenol, 2(or 4)-sec-hexacosyl234446-38-9 Phenol, 2(or 4)-sec-octacosyl234446-39-0 Phenol, 2(or 4)-sec-triacontylRationale and Uncertainties Considered in Prioritization Decision: 

• The five clusters members with estimated log Kow values > 10 are estimated to have low 

acute and chronic aquatic toxicity. Estimated and measured data indicate that the overall 

acute and chronic aquatic toxicity for cluster members with log Kow values < 6 is moderate to 

high. Therefore, information concerning uses and the frequency of releases to water and 

resultant exposures would be useful in determining the extent of potential concern for aquatic 

organisms. 

• Available data indicates moderate repeated-dose and reproductive toxicity, and possible skin 

and eye irritation and skin sensitization. One cluster member (91672-41-2) has a vapor 

pressure above 1.3 × 10-6 hPa, and EPA experience has shown that worker exposure to 

vapors have been a concern for chemicals with vapor pressures above that value. Exposurerelated information would be useful to more completely assess human health concerns for the 

cluster members. 

• EPA’s review of that cluster member (134701-20-5) in the New Chemical Program resulted 

in development of a proposed non-section 5e SNUR which defined any use leading to 

releases of water or lack of appropriate protection in the workplace as a new use requiring 

EPA notification. These regulatory decisions may be relevant for other cluster members. 

Prioritization Decision: 

MEDIUM PRIORITY: consider whether concerns expressed in the SNUR proposed for 

one cluster member should be applied to other cluster members after reviewing use and 

exposure information for the one cluster member (91672-41-2) not reviewed in the New 

Chemicals Program. 

• Recognizing the potential concerns for ecotoxicity and human health effects, the one cluster 

member (91672-41-2) not reviewed under the New Chemicals Program should be referred to 

the Interagency Testing Committee (ITC) as a candidate for the collection of exposurerelated information and unpublished health and safety studies. 

• EPA should evaluate the cluster members against the concerns expressed in the SNUR 

proposed under TSCA section 5(a)(2) for a cluster member (134701-20-5), and consider 

whether comparable (or other) actions may be needed for additional cluster members.
If no units provided - endpoint is unitless

Table A P-Chem Properties and Environmental Alkyl phenols (8)

CASRN 89-72-5 91672-41-2 84852-15-3 134701-20-5 233587-36-5 234446-37-8 234446-38-9 234446-39-Chemical Phenol, 2-(1- methylpropyl)- Phenol, 2- nonyl-, branched Phenol, 4- nonyl-, branched Phenol, 2,4- dimethyl-6-(1- methylpentadecyl)

-

Phenol, 2(or 

4)-sectetracosylPhenol, 2(or 4)-sec- hexacosyl- Phenol, 2(or 4)-sec- octacosyl- Phenol, 2(o

4)-sec- triacontylMolecular 

Weight 150.22 220.36 220.36 346.6 430.76 458.82 486.87 514.93Production Volume

State Liquid LiquidMelting Point (oC) 14 25Boiling Point (oC) 224 300 310 420 490 520 540 560

Vapor Pressure (hPa at 25oC

0.023 0.00034 0.000046 0.000000024 0.00000000012 0.000000000018 0.0000000000028 0.000

Water Solubility (mg/L)

1700 210 1400 0.00003 0.000000034 0.0000000033 0.00000000032 0.000

log Kow 3.46 3.28 3.28 10.4 13.3 14.3 15.3 16.2Koc 2600 41000 40000 11000000 530000000 1800000000 6100000000 10000pKA/pKB 11 11 11.06 12 12 12 12 12HLC (atmm3/mole) 0.0000021 0.000017 0.000017 0.00015 0.0021 0.0042 0.0085 0.017Hydrolysis

PhotolysisPhotooxidation (half-life days) 0.24 0.21 0.21 0.25 0.15 0.14 0.14 0.13

Readily Biodeg No No No No No No No NoRapid Biodeg Yes Yes Yes Yes Yes Yes Yes YesUltimate Biodeg weeks weeks- months weeks- months weeks- months weeks- months weeks- months weeks- months week

mont

Other Biodeg

Other FateFugacity

Air (%) 0.56 0.24 0.24 0 0 0 0 0

Water (%) 25 18 18 1.8 1.8 1.8 1.8 1.9Soil (%) 74 81 81 30 30 30 30 30Sediment (%) 0.69 0.76 0.76 68 68 68 68 68

BCF 16 67 67 3.2 3.2 3.2 3.2 3.2BAF
Table B Aquatic Toxicity

Alkyl phenols (8)CASRN 89-72-5 91672-41-2 84852-15-3 134701-20-5 233587-36-5 234446-37-8 234446-38-9 234446-39-0Chemical Phenol, 2-(1- methylpropyl)- Phenol, 2- nonyl-, branched Phenol, 4- nonyl-, branched Phenol, 2,4- dimethyl-6-(1- methylpentadecyl)

-

Phenol, 2(or 

4)-sectetracosylPhenol, 2(or 4)-sec- hexacosyl- Phenol, 2(or 4)-sec- octacosyl- Phenol, 2(or 4)-sec- triacontylMolecular Weight 150.22 220.36 220.36 346.6 430.76 458.82 486.87 514.93

Production VolumeState Liquid LiquidACUTE

Fish (mg/L) 2.6 0.057 0.13 0.000034 (NES) 0.00000035 (NES) 0.000000072 (NES) 0.000000015 (NES) 0.0000000029 (NES)

Freshwater fish

Freshwater fish

Pimephales promelas

Freshwater fish

Freshwater fish

Freshwater fish

Freshwater fish

Freshwater fish

96h LC50 96h LC50 96h LC50 96h LC50 96h LC50 96h LC50 96h LC50 96h LC50Phenols Phenols Phenols Phenols Phenols Phenols Phenols

Invertebrate (mg/L) 1.3 0.084 0.085 0.0003 (NES) 0.0000091 (NES) 0.0000027 (NES) 0.00000079 (NES) 0.00000023 (NES)

Crangon septemspinosa

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

96h LC50 48h LC50 48h EC50 48h LC50 48h LC50 48h LC50 48h LC50 48h LC50

Phenols Phenols Phenols Phenols Phenols Phenols

Algae (mg/L) 6.1 0.27 0.0563 0.0006 (NES) 0.000014 (NES) 0.0000038 (NES) 0.000001 (NES) 0.00000027 (NES)

Green Algae Green Algae Scenedesmus subspicatus Green Algae Green Algae Green Algae Green Algae Green Algae96h EC50 96h EC50 72h EC50 96h EC50 96h EC50 96h EC50 96h EC50 96h EC50Phenols Phenols Phenols Phenols Phenols Phenols Phenols

CHRONIC

Fish (mg/L) 0.004 0.006 0.014 0.000034 (NES) 0.00000085 (NES) 0.00000023 (NES) 0.000000064 (NES) 0.000000018 (NES)

Freshwater fish

Freshwater fish

Pimephales promelas

Freshwater fish

Freshwater fish

Freshwater fish

Freshwater fish

Freshwater fish

60d ChV 60d ChV 33d LOEC 30d ChV 30d ChV 30d ChV 30d ChV 30d ChVPhenols Phenols Phenols Phenols Phenols Phenols Phenols

Invertebrate (mg/L) 0.28 0.016 0.024 0.000056 (NES) 0.0000017 (NES) 0.0000005 (NES) 0.00000015 (NES) 0.000000043 (NES)

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

Daphnia magna

21d ChV 21d ChV 21d NOEC 21d ChV 21d ChV 21d ChV 21d ChV 21d ChVPhenols Phenols Phenols Phenols Phenols Phenols Phenols
Algae (mg/L) 2.8 0.12 4.1 0.00025 (NES) 0.0000057 (NES) 0.0000015 (NES) 0.0000004 (NES) 0.00000011 (NES)

Green Algae Green Algae Green Algae Green Algae Green Algae Green Algae Green Algae Green AlgaeChV ChV ChV ChV ChV ChV ChV ChVPhenols Phenols Phenols Phenols Phenols Phenols Phenols Phenols
Table C Human Health

Alkyl phenols (8)CASRN 89-72-5 91672-41-2 84852-15-3 134701-20-5 233587-36-5 234446-37-8 234446-38-9 234446-39-0Chemical Phenol, 2-(1- methylpropyl)- Phenol, 2- nonyl-, branched Phenol, 4- nonyl-, branched Phenol, 2,4- dimethyl-6-(1- methylpentadecyl)

-

Phenol, 2(or 

4)-sectetracosylPhenol, 2(or 4)-sec- hexacosyl- Phenol, 2(or 4)-sec- octacosyl- Phenol, 2(or 4)-sec- triacontylMolecular Weight 150.22 220.36 220.36 346.6 430.76 458.82 486.87 514.93

Production Volume

State Liquid LiquidAcute 320 mg/kg 1882 mg/kg

Rat Rat

Repeat Dose 150 mg/kg/day 200 mg/kg/day

Rat Rat90d 28d

Reproductive 52.3 mg/kg/day

Rat6w/pm/3 gen

Developmental 150 mg/kg/day

RatGD 6-15

GenotoxicityCancerEye Irritation

Rabbit

Skin Irritation

Rabbit Rabbit

Skin Sensitization

Guinea Pig

Other Toxicity
Table D Overall Hazard Characteri

Alkyl phenols (8)CASRN 89-72-5 91672-41-2 84852-15-3 134701-20-5 233587-36-5 234446-37-8 23Chemical Phenol, 2-(1- methylpropyl)- Phenol, 2- nonyl-, branched Phenol, 4- nonyl-, branched Phenol, 2,4- dimethyl-6-(1- methylpentadecyl)

-

Phenol, 2(or 

4)-sectetracosylPhenol, 2(or 4)-sec- hexacosyl- Ph

o

Molecular Weight 150.22 220.36 220.36 346.6 430.76 458.82 Production VolumeState Liquid LiquidEnvironmental

Persistence

Bioaccumulation

Aquatic Toxicity

Acute

Chronic

Human Health Effects

Acute Toxicity

Repeated-DoseReproductiveDevelopmentalGenotoxicityCancer HazardEye IrritationSkin IrritationSkin Sensitization
PCHEM/FATE 

Melting Point 

89725 USEPA-HPV-Hazard Characterization 

84852153 USEPA-HPV-Hazard Characterization 

Boiling Point 

89725 USEPA-HPV-Hazard Characterization 

84852153 USEPA-HPV-Hazard Characterization 

91672412 Read across from CASRN 84852-15-3

134701205 EPI v3.2 2007 

233587365 EPI v3.2 2007 

234446378 EPI v3.2 2007 

234446389 EPI v3.2 2007 

234446390 EPI v3.2 2007 

Vapor Pressure 

89725 USEPA-HPV-Hazard Characterization 

84852153 USEPA-HPV-Hazard Characterization 

91672412 EPI v3.2 2007 

134701205 EPI v3.2 2007 

233587365 EPI v3.2 2007 

234446378 EPI v3.2 2007 

234446389 EPI v3.2 2007 

234446390 EPI v3.2 2007 

Water Solubility 

89725 EPI v3.2 2007 

84852153 EPI v3.2 2007 

91672412 EPI v3.2 2007 

134701205 EPI v3.2 2007 

233587365 EPI v3.2 2007 

234446378 EPI v3.2 2007 

234446389 EPI v3.2 2007 

234446390 EPI v3.2 2007 

Log Kow 

89725 USEPA-HPV-Hazard Characterization 

84852153 USEPA-HPV-Hazard Characterization 

91672412 Read-Across from 84852153 

134701205 EPI v3.2 2007 

233587365 EPI v3.2 2007 

234446378 EPI v3.2 2007 

234446389 EPI v3.2 2007 

234446390 EPI v3.2 2007 

Koc 

89725 EPI v3.2 2007 

84852153 EPI v3.2 2007 
91672412 EPI v3.2 2007 

134701205 EPI v3.2 2007 

233587365 EPI v3.2 2007 

234446378 EPI v3.2 2007 

234446389 EPI v3.2 2007 

234446390 EPI v3.2 2007 

pKa/pKb 

89725 SPARC Online Calculator v4.2 

84852153 EFDB 

91672412 SPARC Online Calculator v4.2 

134701205 SPARC Online Calculator v4.2 

233587365 SPARC Online Calculator v4.2 

234446378 SPARC Online Calculator v4.2 

234446389 SPARC Online Calculator v4.2 

234446390 SPARC Online Calculator v4.2 

Henry's Law Constant

89725 EPI v3.2 2007 

84852153 EPI v3.2 2007 

91672412 EPI v3.2 2007 

134701205 EPI v3.2 2007 

233587365 EPI v3.2 2007 

234446378 EPI v3.2 2007 

234446389 EPI v3.2 2007 

234446390 EPI v3.2 2007 

Photooxidation 

89725 EPI v3.2 2007 

84852153 EPI v3.2 2007 

91672412 EPI v3.2 2007 

134701205 EPI v3.2 2007 

233587365 EPI v3.2 2007 

234446378 EPI v3.2 2007 

234446389 EPI v3.2 2007 

234446390 EPI v3.2 2007 

Ready Biodegradation 

89725 USEPA-HPV-Hazard Characterization 

84852153 USEPA-HPV-Hazard Characterization 

91672412 EPI v3.2 2007 

134701205 EPI v3.2 2007 

233587365 EPI v3.2 2007 

234446378 EPI v3.2 2007 

234446389 EPI v3.2 2007 

234446390 EPI v3.2 2007 

Rapid Biodegradation 
89725 EPI v3.2 2007 

84852153 EPI v3.2 2007 

91672412 EPI v3.2 2007 

134701205 EPI v3.2 2007 

233587365 EPI v3.2 2007 

234446378 EPI v3.2 2007 

234446389 EPI v3.2 2007 

234446390 EPI v3.2 2007 

Ultimate Biodegradation 

89725 EPI v3.2 2007 

84852153 EPI v3.2 2007 

91672412 EPI v3.2 2007 

134701205 EPI v3.2 2007 

233587365 EPI v3.2 2007 

234446378 EPI v3.2 2007 

234446389 EPI v3.2 2007 

234446390 EPI v3.2 2007 

Fugacity 

89725 EPI v3.2 2007 

84852153 EPI v3.2 2007 

91672412 EPI v3.2 2007 

134701205 EPI v3.2 2007 

233587365 EPI v3.2 2007 

234446378 EPI v3.2 2007 

234446389 EPI v3.2 2007 

234446390 EPI v3.2 2007 

BCF 

89725 Japan’s Ministry of Economy, Trade, and Industry’s MITI Biodegradation Database 

84852153 EPI v3.2 2007 

91672412 Read across from CASRN 84852-15-3.

134701205 EPI v3.2 2007 

233587365 EPI v3.2 2007 

234446378 EPI v3.2 2007 

234446389 EPI v3.2 2007 

234446390 EPI v3.2 2007 

ECOTOXICITY 

Acute Fish 

89725 ECOSAR v.1.00 

84852153 USEPA-HPV 

91672412 ECOSAR v.1.00 

134701205 ECOSAR v.1.00 

233587365 ECOSAR v.1.00 

234446378 ECOSAR v.1.00 
234446389 ECOSAR v.1.00 

234446390 ECOSAR v.1.00 

Acute Daphnid 

89725 USEPA-HPV 

84852153 USEPA-HPV 

91672412 ECOSAR v.1.00 

134701205 ECOSAR v.1.00 

233587365 ECOSAR v.1.00 

234446378 ECOSAR v.1.00 

234446389 ECOSAR v.1.00 

234446390 ECOSAR v.1.00 

Acute Algae 

89725 ECOSAR v.1.00 

84852153 USEPA-HPV 

91672412 ECOSAR v.1.00 

134701205 ECOSAR v.1.00 

233587365 ECOSAR v.1.00 

234446378 ECOSAR v.1.00 

234446389 ECOSAR v.1.00 

234446390 ECOSAR v.1.00 

Chronic Fish 

89725 ECOSAR v.1.00 

84852153 USEPA-HPV 

91672412 ECOSAR v.1.00 

134701205 ECOSAR v.1.00 

233587365 ECOSAR v.1.00 

234446378 ECOSAR v.1.00 

234446389 ECOSAR v.1.00 

234446390 ECOSAR v.1.00 

Chronic Daphnid 

89725 ECOSAR v.1.00 

84852153 USEPA-HPV 

91672412 ECOSAR v.1.00 

134701205 ECOSAR v.1.00 

233587365 ECOSAR v.1.00 

234446378 ECOSAR v.1.00 

234446389 ECOSAR v.1.00 

234446390 ECOSAR v.1.00 

Chronic Algae 

89725 ECOSAR v.1.00 

84852153 ECOSAR v.1.00 

91672412 ECOSAR v.1.00 

134701205 ECOSAR v.1.00 
233587365 ECOSAR v.1.00 

234446378 ECOSAR v.1.00 

234446389 ECOSAR v.1.00 

234446390 ECOSAR v.1.00 

HUMAN HEALTH 

Acute Toxicity 

89725 ChemIDPlus 

84852153 USEPA-HPV` 

Repeat Dose 

84852153 USEPA-HPV 

134701205 USEPA-TSCATS section 8E 

Reproductive 

84852153 USEPA-HPV 

Developmental 

84852153 USEPA-HPV 

Genotoxicity 

89725 USEPA-HPV 

84852153 USEPA-HPV 

Cancer 

89725 OncoLogic 

84852153 OncoLogic 

91672412 OncoLogic 

134701205 OncoLogic 

233587365 OncoLogic 

234446378 OncoLogic 

234446389 OncoLogic 

234446390 OncoLogic 

Eye Irritation 

84852153 USEPA-HPV 

Skin Irritation 

89725 USEPA-HPV 

84852153 USEPA-HPV 

Skin Sensitization 

84852153 USEPA-HPV