**UNITEDSTATES**

**SECURITIESAND EXCHANGE COMMISSION**

**Washington, D.C. 20549**

 

**Form 10-K/A**

 

**Amendment No. 2**

 

**(Mark One)**
| **x**                                                                                                                                                                                                                                                                                                          | **ANNUAL  REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE  ACT OF 1934**     |
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                                                                           |
| **For the fiscal year ended December 31, 2007**                                                                                                                                                                                                                                                           |
|                                                                                                                                                                                                                                                                                                           |
| **or**                                                                                                                                                                                                                                                                                                         |
|                                                                                                                                                                                                                                                                                                           |
| **o**                                                                                                                                                                                                                                                                                                          | **TRANSITION  REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE SECURITIES EXCHANGE  ACT OF 1934** |
| ** **                                                                                                                                                                                                                                                                                                     | ** **                                                                                               |
| **For the transition period  from                      to                      .** |

 

**Commission file number: 000-28229**

 

**CaliperLife Sciences, Inc.**

(Exact name of registrant as specified in its charter)

 

| **Delaware**                             | ** ** | **33-0675808**      |
|------------------------------------------|------------|---------------------|
| (State or other jurisdiction of          |       | (I.R.S. Employer    |
| incorporation or organization)           |       | Identification No.) |
|                                     |       |                |
| **68 Elm Street**                        | ** ** | ** **          |
| **Hopkinton, MA**                        | ** ** | **01748**           |
| (Address of principal executive offices) |       | (Zip Code)          |

 

Registrant’s telephone number, including area code**(508) 435-9500**

 

Securities registered pursuant to Section 12(b) of theExchange Act:

 

| **Title of each class**                  | ** ** | **Name of exchange on which registered** |
|------------------------------------------|------------|------------------------------------------|
| Common Stock, $0.001 Par Value Per Share |       | NASDAQ Global Market                     |

 

Securities registered pursuant to Section 12(g) of theExchange Act:**None**

 

Indicateby check mark if the registrant is a well-known seasoned issuer, as defined in Rule 405of the Securities Act. Yeso   Nox

 

Indicateby check mark if the registrant is not required to file reports pursuant to Section 13or Section 15(d) of the Exchange Act. Yeso   No   x

 

Indicateby check mark whether the registrant (1) has filed all reports required tobe filed by Section 13 or 15(d) of the Securities Exchange Act of1934 during the preceding 12 months (or for such shorter period that theregistrant was required to file such reports), and (2) has been subject tosuch filing requirements for the past 90 days. Yes  x   No  o

 

Indicateby check mark if disclosure of delinquent filers pursuant to Item 405 ofRegulation S-K is not contained herein, and will not be contained, to the bestof registrant’s knowledge, in definitive proxy or information statementsincorporated by reference in Part III of this Form 10-K or anyamendment to this Form 10-K.   x

 

Indicate by check markwhether the registrant is a large accelerated filer, an accelerated filer, anon-accelerated filer, or a smaller reporting company. See definitions of“large accelerated filer,” “accelerated filer,” and “smaller reporting company”in Rule 12b-2 of the Exchange Act. (Check one):

 

| Large accelerated filer  o                     |   | Accelerated filer x          |
|------------------------------------------------|--------|-----------------------------------|
|                                           |   |                              |
| Non-accelerated filer o                        |   | Smaller reporting  company o |
| (Do not check if a  smaller reporting company) |   |                              |

 

Indicateby check mark whether the registrant is a shell company (as defined in Rule 12b-2of the Exchange Act). Yes o   Nox

 

Theaggregate market value of the registrant’s voting and non-voting common stockheld by non-affiliates of the registrant (without admitting that any personwhose shares are not included in such calculation is an affiliate), as of thelast business day of the registrant’s most recently completed second fiscalquarter was $222.1 million.

 

Asof March 7, 2008, the registrant had 47,697,679 shares of common stockoutstanding.

 

 

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**EXPLANATORY NOTE**

 

CaliperLife Sciences, Inc. is filing this amendment No. 2 to its AnnualReport on Form 10-K, originally filed with the Securities and ExchangeCommission on March 14, 2008 and amended on March 17, 2008 (“AmendmentNo. 1”), solely to correct a typographical error in the Certifications ofPrincipal Executive Officer and Principal Financial Officer required by Section 302of the Sarbanes-Oxley Act of 2002 in Amendment No. 1.

 

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**PART IV**

 

**Item 15.    Exhibits and Financial Statement Schedules**

 

(a)           The following documents are filed asa part of this Annual Report:

 

(3)           *Exhibits:*

 

        Thefollowing is a list of exhibits filed as part of this Amendment No. 2 tothe Form 10-K:

 
| **Exhibit**** ****Number** | ** ** | **Description of Document**                                                         |
|---------------------------------|------------|-----------------------------------------------------------------------------------------------|
|                            |       |                                                                                          |
| 31.1                            |       | Certification of Chief Executive Officer pursuant to  Rule 13a-14(a) and 15d-14(a)  |
|                            |       |                                                                                          |
| 31.2                            |       | Certification of Chief Financial Officer pursuant to  Rule 13a-14(a) and 15d-14(a). |

 

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**SIGNATURES**

Pursuant to therequirements of Section 13 or 15(d) of the Securities Exchange Act of1934, the Registrant has duly caused this Amendment No. 2 to the Form 10-Kto be signed on its behalf by the undersigned, thereunto duly authorized.

 
|                         | **CALIPER  LIFE SCIENCES, INC.** |
|------------------------------|---------------------------------------|
|                         | By:                                   | /s/ PETER F.  MCAREE |
|                         |                                  | Peter F. McAree |
| * *                     | * *                              | *Chief  Financial Officer* |
| Date: May 7,  2008 |                                  |   |

 

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**EXHIBITINDEX**

 

*Exhibits:*

 
| **Exhibit**** ****Number** | ** ** | **Description of Document**                                                         |
|---------------------------------|------------|-----------------------------------------------------------------------------------------------|
|                            |       |                                                                                          |
| 31.1                            |       | Certification of Chief Executive Officer pursuant to  Rule 13a-14(a) and 15d-14(a)  |
|                            |       |                                                                                          |
| 31.2                            |       | Certification of Chief Financial Officer pursuant to  Rule 13a-14(a) and 15d-14(a). |

 

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