<PAGE>


                                                                    Exhibit 10.2


                       RETENTION AND SEVERANCE AGREEMENT

                  THIS RETENTION AND SEVERANCE AGREEMENT (this "AGREEMENT"),
dated as of March 1, 2000, is made by and between DAOU Systems, Inc., a Delaware
corporation ("DAOU"), DAOU-Sentient, Inc., a Delaware corporation and a
wholly-owned subsidiary of DAOU ("DAOU-SENTIENT"), and Stephen M. Casey
("EMPLOYEE").

                                    RECITALS

         WHEREAS, DAOU and each of its wholly-owned subsidiaries (collectively,
the COMPANY") recognize that the possibility of a Change in Control (as defined
below) of DAOU exists and that such possibility, including the uncertainty that
such possibility may raise among the Company's key employees, may result in the
departure or distraction of such employees to the detriment of the Company and
DAOU's stockholders;

         WHEREAS, DAOU's Board of Directors has determined that appropriate
steps should be taken to reinforce and encourage the continued employment of the
Company's key employees without distraction from the possibility of a Change in
Control of DAOU or any related events and circumstances;

         WHEREAS, Employee is a key employee of the Company;

         WHEREAS, Employee has entered into an Employment Agreement with
DAOU-Sentient dated as of March 30, 1998 (the "EMPLOYMENT AGREEMENT");

         WHEREAS, the Company considers that providing Employee with certain
retention and severance benefits will operate as an incentive for Employee to
remain employed by the Company in the event of a Change in Control of DAOU.

         NOW THEREFORE, to induce Employee to remain employed by the Company,
and for other good and valuable consideration, the receipt and sufficiency of
which are hereby acknowledged, DAOU, DAOU-Sentient and Employee agree as
follows:

                                   AGREEMENT

1.       DEFINITIONS.

         1.1 "BASE SALARY" shall mean the Employee's gross annual salary as of
the Termination Date.

         1.2 "CAUSE" shall mean:

             (a) Employee's material breach of the Employment Agreement;

             (b) Employee's material failure to adhere to any written policy of
the Company generally applicable to officers of the Company if Employee has been
given a reasonable opportunity (but in no event later than thirty (30) days) to
comply with such policy or cure his failure to comply after receiving notice of
such failure;


<PAGE>


             (c) Employee's appropriation (or attempted appropriation) of a
material business opportunity of the Company, including attempting to secure or
securing any personal profit in connection with any transaction entered into on
behalf of the Company;

             (d) Employee's misappropriation (or attempted misappropriation) of
any of the Company's funds or property;

             (e) the conviction of Employee, or the entering of a guilty plea or
plea of no contest by Employee with respect to, a felony, the equivalent
thereof, or any other crime with respect to which imprisonment is a possible
punishment;

             (f) willful misconduct;

             (g) Employee's physical or mental disability or other inability to
perform the essential functions of his position, with or without reasonable
accommodation; or

             (h) Employee's death.

         1.3 "CHANGE OF CONTROL" is defined to have occurred if, and only if,
during Employee's employment:

             (a) any individual, partnership, firm, corporation, association,
trust, unincorporated organization or other entity or person, or any syndicate
or group deemed to be a person under Section 14(d)(2) of the Exchange Act is or
becomes the "Beneficial Owner" (as defined in Rule 13d-3 of the General Rules
and Regulations under the Exchange Act), directly or indirectly, of securities
of DAOU representing fifty percent (50%) or more of the combined voting power of
DAOU's then outstanding securities entitled to vote in the election of directors
of DAOU;

             (b) there occurs a reorganization, merger, consolidation or other
corporate transaction involving DAOU (a "TRANSACTION"), in each case, with
respect to which the stockholders of DAOU immediately prior to such Transaction
do not, immediately after the Transaction, own more than fifty percent (50%) of
the combined voting power of DAOU or other corporation resulting from such
Transaction; or

             (c) all or substantially all of the assets of DAOU are sold,
liquidated or distributed.

         1.4 "CODE" shall mean the Internal Revenue Code of 1986, as amended.

         1.5 [Reserved.]

         1.6 "EXCHANGE ACT" shall mean the Securities Exchange Act of 1934, as
amended.

         1.7 [Reserved.]

         1.8 [Reserved.]


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<PAGE>


         1.9 "RETENTION BONUS" shall mean the payment made pursuant to SECTION 4
of this Agreement.

         1.10 "RESIGNATION FOR GOOD REASON" shall mean the voluntary resignation
by Employee of his employment with the Company within two (2) years following a
Change in Control and within three (3) months of any of the following "GOOD
REASONS":

             (a) any reduction in Employee's Base Salary or Target Bonus;

             (b) any significant reduction in Employee's responsibilities and/or
authority; or

             (c) a relocation by the Company of Employee's place of Employment
outside a twenty-five (25) mile radius of Employee's current place of
employment.

An event described in Section 1.10(a) through (c) will not constitute Good
Reason unless Employee provides written notice to the Company (or its successor)
of his intention to resign for Good Reason and unless the Company (or its
successor) does not cure the Good Reason within ten (10) days of the Company's
(or its successor's) receipt of the written notice.

         1.11 "TARGET BONUS" shall mean the variable annual cash compensation
that Employee is eligible to receive, prior to a Change in Control, as
additional compensation or as an incentive bonus in the event targeted goals are
achieved for the year.

         1.12 "TERMINATION DATE" shall mean the date of termination of
Employee's employment relationship with the Company.

         1.13 "TERMINATION PAYMENTS" shall mean any payment or distribution of
compensation or benefits made pursuant to SECTIONS 5.1 (a)-(d) of this
Agreement.

2. TITLE AND DUTIES. Employee currently holds the positions of Director and
President and Chief Executive Officer of DAOU-Sentient and Director and
President and Chief Executive Officer of Enosus, Inc, a wholly-owned subsidiary
of DAOU. Employee will: (i) devote his entire business time, attention, skill,
and energy exclusively to the business of the Company; (ii) use his best efforts
to promote the success of the Company's business; and (iii) cooperate fully with
the President and the Board of Directors of the Company in the advancement of
the best interests of the Company.

3. AT-WILL EMPLOYMENT. Employee reaffirms that Employee's employment
relationship with the Company is at-will, terminable at any time and for any
reason by either the Company or Employee. While certain paragraphs of this
Agreement describe events that could occur at a particular time in the future,
nothing in this Agreement may be construed as a guarantee of employment of any
length.

4. RETENTION BONUS. If the Employee is continuously employed by the Company from
the date of this Agreement through the consummation of a Change in Control,
then, within fifteen (15) days after the consummation of such Change in Control,
DAOU (or its successor) shall pay to Employee a lump sum amount equal to Two
Hundred Seventy-Five Thousand Dollars


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<PAGE>


($275,000), less applicable state and federal taxes and/or other payroll
deductions (the "RETENTION BONUS"). Such payment of the Retention Bonus shall be
in addition to any compensation paid to Employee hereunder or under the
Employment Agreement.

5. TERMINATION PAYMENTS. The provisions of this Section 5 of this Agreement
shall replace the provisions of Section 8 of the Employment Agreement, and the
Employment Agreement shall be deemed to be amended accordingly.

         5.1 If, within two (2) years immediately following a Change in Control,
Employee's employment with the Company (or its successor) terminates as the
result of (i) termination by the Company (or its successor) of Employee's
employment for a reason other than Cause or (ii) Employee's Resignation for Good
Reason:

             (a) Employee will receive a pro-rata share of the Base Salary and
Target Bonus accrued and owing to Employee through the Termination Date, less
applicable state and federal taxes and/or other payroll deductions, and accrued
but unused vacation, sick days and floating holidays through the Termination
Date in accordance with the Company's (or its successor's) regular policies,
less applicable state and federal taxes and/or other payroll deductions;

             (b) Within fifteen (15) days after the Termination Date, DAOU (or
its successor) shall pay to Employee a severance payment in a lump-sum amount
equal to Five Hundred Fifty Thousand Dollars ($550,000), less applicable state
and federal taxes and/or other payroll deductions;

             (c) [Reserved.]

             (d) If Employee elects to continue insurance coverage as afforded
to Employee according to the Consolidated Omnibus Budget Reconciliation Act of
1985 ("COBRA"), DAOU (or its successor) will reimburse Employee the amount of
the premiums incurred by Employee during the period beginning on the Termination
Date and extend for twelve (12) months following the Termination Date. Nothing
in this Agreement will extend Employee's COBRA period beyond the period allowed
under COBRA, nor is the Company assuming any responsibility which Employee has
for formally electing to continue coverage;

         5.2 The Termination Payments set forth in SECTIONS 5.1(b), (c) AND (d)
above are in exchange for, and contingent upon Employee's execution of a release
of all claims as of the Termination Date, in substantially the form attached to
this Agreement as EXHIBIT 1.

         5.3 If Employee's employment terminates at any time prior to a Change
of Control or after the two (2) year period immediately following a Change in
Control as the result of (i) termination by the Company (or its successor) of
Employee's employment for a reason other than Cause, or (ii) Employee's
Resignation for Good Reason, Employee will be entitled to receive (A) payments
in an aggregate amount equal to the Base Salary, payable over a twelve (12)
month period following the Termination Date, (B) that part of the Target Bonus,
if any, for the fiscal year in which such termination occurs, prorated through
the end of the calendar month during which such termination occurs and (C)
accrued but unused vacation, sick days and floating holidays through the
Termination Date in accordance with the Company's (or its


                                       4
<PAGE>


successor's) regular policies, each less applicable state and federal taxes
and/or other payroll deductions.

         5.4 If Employee's employment with the Company terminates (i) for Cause
or (ii) due to Employee's resignation without Good Reason, then DAOU (or its
successor) will pay to Employee a pro-rata share of the Base Salary and Target
Bonus accrued and owing to Employee through the Termination Date, less
applicable state and federal taxes and/or other payroll deductions, and accrued
but unused vacation, sick days and floating holidays through the Termination
Date in accordance with the Company's (or its successor's) regular policies,
less applicable state and federal taxes and/or other payroll deductions.

         5.5 If Employee resigns his employment for Good Reasons described in
Section 1.10 (b) above, payment of the above Termination Payments is further
contingent upon Employee's willingness, at the Company's (or its successor's)
request, to continue performing his duties on behalf of the Company (or its
successor) in good faith for up to sixty (60) days following the occurrence of
the events described in Section 1.10 (b); PROVIDED, HOWEVER, that Employee shall
not be required to travel to perform his duties in good faith. DAOU (or its
successor) will pay to Employee a pro-rata share of the Base Salary and Target
Bonus and accrued but unused vacation, sick days and floating holidays according
to the Company's (or its successor's) regular policies, less applicable state
and federal taxes and/or other payroll deductions, during the up-to sixty (60)
day period and will receive the Termination Payments upon completion of that
period.

         5.6 Upon the Termination Date, Employee shall be entitled to take
possession of the office furnishings which are located in his office at
DAOU-Sentient, including a desk, a credenza, a bookshelf and chairs.

6. RETIREMENT AND PROFIT-SHARING PLANS. Notwithstanding anything in this
Agreement to the contrary, Employee's rights in any retirement, pension or
profit-sharing plans offered by the Company shall be governed by the rules of
such plans as well as by applicable law.

7. TAX CONSEQUENCES. The Company makes no representations regarding the tax
consequence of any provision of this Agreement. Employee is advised to consult
with his own tax advisor with respect to the tax treatment of any payment
contained in this Agreement.

8. TAX ADJUSTMENT. Notwithstanding the foregoing or any other provision of this
Agreement to the contrary, if tax counsel selected by the Company and acceptable
to Employee determines that any portion of any payment under this Agreement
would constitute an "excess parachute payment" within the meaning of Section
280G of the Code, the payments to be made to Employee under this Agreement shall
be reduced (but not below zero) such that the value of the aggregate payments
that Employee is entitled to receive under this Agreement, and any other
agreement or plan or program of the Company, shall be one dollar ($1) less than
the maximum amount of payments which Employee may receive without becoming
subject to the tax imposed by Section 4999 of the Code.

9. DISPUTE RESOLUTION PROCEDURES. Any dispute or claim arising out of this
Agreement shall be subject to final and binding arbitration. The arbitration
will be conducted by one arbitrator who is a member of the American Arbitration
Association ("AAA") or of the Judicial Arbitration


                                       5
<PAGE>


and Mediation Services ("JAMS"), and will be conducted under the Expedited
Procedures for Commercial Arbitration Rules of the AAA, or such similar
procedures as may be in effect (the "Rules"). The arbitration shall be held in
Montgomery County, Maryland. The parties will select the arbitrator from a list
maintained by the AAA or JAMS and the parties agree that they will have five (5)
Business Days in which to return the list to AAA or JAMS with their objections
and preferences. Discovery will be limited to no more than seven (7) depositions
by each side and written document requests, requesting the production of
specific documents. The parties to the dispute will voluntarily produce any and
all documents that they intend to use at the hearing before the close of
discovery, subject to supplementation for purposes of rebuttal of good cause
shown. The period for taking discovery shall be sixty (60) Business Days,
commencing upon the day that the answer is due under the Rules. The arbitrator
will hold a pre-hearing conference within three (3) Business Days of the close
of discovery and will schedule the hearing within thirty (30) Business Days of
the close of discovery. After the arbitrator is selected, the arbitrator shall
have all authority to determine the arbitrability of any claim and enter a final
and binding judgment at the conclusion of any proceedings in respect of the
arbitration. Any final judgment only may be appealed on the grounds of improper
bias or improper conduct of the arbitrator. All fees and costs will be allocated
to the parties to the arbitration as determined by the arbitrator. Each party
will initially pay its own fees and costs associated with the arbitration and
each party will pay one-half of the arbitrator's fees up front, subject to the
arbitrator's final determination on fees and costs.

10.      GENERAL PROVISIONS.

         10.1 GOVERNING LAW. This Agreement will be governed by and construed in
accordance with the laws of California.

         10.2 ASSIGNMENT. Employee may not assign, pledge or encumber his
interest in this Agreement or any part thereof.

         10.3 AMENDMENTS; WAIVERS. No amendment of any provision of this
Agreement shall be valid unless the same shall be in writing and signed by both
of the parties. No waiver of any provision or consent to any exception to the
terms of this Agreement or any agreement contemplated hereby will be effective
unless in writing and signed by the party to be bound and then only to the
specific purpose, extent, and instance so provided.

         10.4 SEVERABILITY. The provisions of this Agreement are severable; and,
if any provision will be held to be invalid or otherwise unenforceable, in whole
or in part, then the remainder of the provisions, or enforceable parts of this
Agreement, will not be affected.

         10.5 NOTICES. All notices, consents, waivers, and other communications
under this Agreement must be in writing and will be deemed to have been duly
given when (a) delivered by hand (with written confirmation of receipt), (b)
sent by facsimile (with written confirmation of receipt), provided that a copy
is mailed by registered mail, return receipt requested or (c) when received by
the addressee, if sent by a nationally recognized overnight delivery service
(receipt requested), in each case to the appropriate addresses and facsimile
numbers set forth below (or to such other addresses and facsimile numbers as a
party may designate by notice to the other parties):


                                       6
<PAGE>


            If to the Company:        DAOU Systems, Inc.
                                      5120 Shoreham Place
                                      San Diego, CA  92122
                                      ATTENTION:  Chief Executive Officer
                                      Facsimile No.: (619) 452-2789


            With a copy to:           Baker & McKenzie
                                      101 West Broadway, Twelfth Floor
                                      San Diego, California  92101-3890
                                      ATTENTION:  Carlos D. Heredia, Esq.
                                      Facsimile No.: (619) 236-0429


            If to Employee:           Stephen M. Casey
                                      21608 Goshen Oaks Road
                                      Laytonsville, Maryland 20882
                                      Facsimile No.: 301-929-7677


             With a copy to:          Linowes and Blocher LLP
                                      1010 Wayne Avenue, Suite 1000
                                      Silver Spring, Maryland 20910
                                      ATTENTION:  John R. Orrick, Jr.
                                      Facsimile No. 301-495-9044.

         10.6 ENTIRE AGREEMENT. This Agreement constitutes the entire agreement
of the parties with respect to the subject matter of this Agreement, and
supersedes all prior and contemporaneous negotiations, agreements and
understandings between the parties, oral or written. To the extent that the
provisions of the Employment Agreement do not conflict with this Agreement, such
provisions of the Employment Agreement shall remain in full force and effect.

         10.7 MODIFICATION; WAIVERS. No modification, termination or attempted
waiver of this Agreement will be valid unless in writing, signed by the party
against whom such modification, termination or waiver is sought to be enforced.

         10.8 AMENDMENT. This Agreement may be amended or supplemented only by a
writing signed by both of the parties hereto.

         10.9 COUNTERPARTS. This Agreement may be executed in counterparts, each
of which shall be deemed an original; PROVIDED, HOWEVER, that such counterparts
shall together constitute only one instrument.

         10.10 INTERPRETATION. The headings contained in this Agreement are for
reference purposes only and shall not affect in any way the meaning or
interpretation of this Agreement.

         10.11 DRAFTING AMBIGUITIES. Each party to this Agreement and its
counsel have reviewed and revised this Agreement. The rule of construction that
any ambiguities are to be


                                       7
<PAGE>


resolved against the drafting party shall not be employed in the interpretation
of this Agreement or any of the amendments to this Agreement.

                  [REMAINDER OF PAGE INTENTIONALLY LEFT BLANK]



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<PAGE>


IN WITNESS WHEREOF, the parties hereto have executed this Agreement as of the
date first above written.

                                             DAOU SYSTEMS, INC.



                                             By: /s/ Larry Grandia
                                                 -------------------------------
                                                 Larry Grandia, President and
                                                 Chief Executive Officer



                                             DAOU-SENTIENT, INC.



                                             By: /s/ Donald R. Myll
                                                 -------------------------------
                                                 Donald R. Myll
                                                 Vice President



                                             EMPLOYEE:



                                             /s/ Stephen M. Casey
                                             -----------------------------------
                                             Stephen M. Casey


                                       9
<PAGE>


                                   EXHIBIT 1

                                GENERAL RELEASE

         THIS GENERAL RELEASE (this "RELEASE") is entered into effective as of
______________, ____, (the "EFFECTIVE DATE") by and between DAOU Systems, Inc.,
a Delaware corporation, having its principal offices at 5120 Shoreham Place, San
Diego, California 92122 (the "COMPANY"), and Stephen M. Casey ("EMPLOYEE"), with
reference to the following facts:

                                    RECITALS

         A. The parties entered into a Retention and Severance Agreement, dated
as of March 1, 2000 (the "AGREEMENT"), pursuant to which the parties agreed that
upon the occurrence of certain conditions, Employee would become eligible for
certain Termination Payments (as defined in the Agreement) in exchange for
Employee's release of the Company from all claims which Employee may have
against the Company as of the Termination Date (as defined in the Agreement).
Capitalized terms not otherwise defined herein shall have the respective
meanings ascribed to them in the Agreement.

         B. The parties desire to dispose of, fully and completely, all claims,
which Employee may have against the Company in, the manner set forth in this
Release.

                                   AGREEMENT

         1. RELEASE. Employee, for himself and his heirs, successors and
assigns, each fully releases, and discharges the Company, its officers,
directors, employees, shareholders, attorneys, accountants, other professionals,
insurers and agents of the other (collectively "AGENTS"), and all entities
related to each party, including, but not limited to, their respective heirs,
executors, administrators, personal representatives, assigns, parent, subsidiary
and sister corporations, affiliates, partners and co-venturers (collectively
"RELATED ENTITIES"), from all rights (except for those rights that Employee may
have as a stockholder of the Company), claims, demands, actions, causes of
action, liabilities and obligations of every kind, nature and description
whatsoever, Employee now has, owns or holds or has at anytime had, owned or held
or may have against the Company, Agents or Related Entities from any source
whatsoever, whether or not arising from or related to the facts recited in this
Release. Employee specifically releases and waives any and all claims arising
under any express or implied contract, rule, regulation or ordinance, including,
without limitation, Title VII of the Civil Rights Act of 1964, the Civil Rights
Act of 1991, the Americans with Disabilities Act, the California Fair Employment
and Housing Act, and the Age Discrimination in Employment Act, as amended
("ADEA").

         2. SECTION 1542 WAIVER. This Release is intended as a full and complete
release and discharge of any and all claims that Employee may have against the
Company, its Agents or Related Entities. In making this release, Employee
intends to release the Company, its Agents and Related Entities from liability
of any nature whatsoever for any claim of damages or injury or for equitable or
declaratory relief of any kind, whether the claim, or any facts on which such
claim might be based, is known or unknown to him. Employee expressly waives all
rights under Section 1542 of the California Civil Code, which Employee
understands provides as follows:


                                       1
<PAGE>


              A GENERAL RELEASE DOES NOT EXTEND TO CLAIMS WHICH THE
              CREDITOR DOES NOT KNOW OR SUSPECT TO EXIST IN HIS FAVOR AT
              THE TIME OF EXECUTING THE RELEASE, WHICH IF KNOWN BY HIM
              MUST HAVE MATERIALLY AFFECTED HIS SETTLEMENT WITH THE
              DEBTOR.

Employee acknowledges that he may discover facts different from or in addition
to those that he now believes to be true with respect to this Release. Employee
agrees that this Release shall remain effective notwithstanding the discovery of
any different or additional facts.

         3. WAIVER OF CERTAIN CLAIMS. Employee acknowledges that he has been
advised in writing of his right to consult with an attorney prior to executing
the waivers set out in this Release, and that he has been given a 21-day period
in which to consider entering into the release of ADEA claims, if any. In
addition, Employee acknowledges that he has been informed that he may revoke a
signed waiver of the ADEA claims for up to seven (7) days after executing this
Release.

         4. NO UNDUE INFLUENCE. This Release is executed voluntarily and without
any duress or undue influence. Employee acknowledges he has read this Release
and executed it with his full and free consent. No provision of this Release
shall be construed against any party by virtue of the fact that such party or
its counsel drafted such provision or the entirety of this Release.

         5. GOVERNING LAW. This Release is made and entered into in the State of
California and accordingly the rights and obligations of the parties hereunder
shall in all respects be construed, interpreted, enforced and governed in
accordance with the laws of the State of California as applied to contracts
entered into by and between residents of California to be wholly performed
within California, without regard to conflicts of law principles.

         6. SEVERABILITY. If any provision of this Release is held to be
invalid, void or unenforceable, the balance of the provisions of this Release
shall, nevertheless, remain in full force and effect and shall in no way be
affected, impaired or invalidated.

         7. CONSULTATION WITH COUNSEL. Employee acknowledges and agrees that he
has had the opportunity to consult and review this Release with counsel.

         8. DISPUTE RESOLUTION PROCEDURES. Any dispute or claim arising out of
this Release shall be subject to final and binding arbitration. The arbitration
will be conducted by one arbitrator who is a member of the American Arbitration
Association ("AAA") or of the Judicial Arbitration and Mediation Services
("JAMS"), and will be conducted under the Expedited Procedures for Commercial
Arbitration Rules of the AAA, or such similar procedures as may be in effect
(the "Rules"). The arbitration shall be held in Montgomery County, Maryland. The
parties will select the arbitrator from a list maintained by the AAA or JAMS and
the parties agree that they will have five (5) Business Days in which to return
the list to AAA or JAMS with their objections and preferences. Discovery will be
limited to no more than seven (7) depositions by each side and written document
requests, requesting the production of specific documents. The


                                       2
<PAGE>


parties to the dispute will voluntarily produce any and all documents that they
intend to use at the hearing before the close of discovery, subject to
supplementation for purposes of rebuttal of good cause shown. The period for
taking discovery shall be sixty (60) Business Days, commencing upon the day that
the answer is due under the Rules. The arbitrator will hold a pre-hearing
conference within three (3) Business Days of the close of discovery and will
schedule the hearing within thirty (30) Business Days of the close of discovery.
After the arbitrator is selected, the arbitrator shall have all authority to
determine the arbitrability of any claim and enter a final and binding judgment
at the conclusion of any proceedings in respect of the arbitration. Any final
judgment only may be appealed on the grounds of improper bias or improper
conduct of the arbitrator. All fees and costs will be allocated to the parties
to the arbitration as determined by the arbitrator. Each party will initially
pay its own fees and costs associated with the arbitration and each party will
pay one-half of the arbitrator's fees up front, subject to the arbitrator's
final determination on fees and costs.





Dated:
      -------------------------------     ---------------------------------
                                          Stephen M. Casey





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