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                                                                   EXHIBIT 10.30


                      AMENDMENT NO. 1 TO LICENSE AGREEMENT
                            OF MARCH 22, 1988 BETWEEN
                         AMARILLO BIOSCIENCES, INC. AND
                         THE TEXAS A&M UNIVERSITY SYSTEM


                  THIS AMENDMENT NO. 1 ("Amendment") is entered into as of this
the ____ day of __________________, 1998, by and between AMARILLO BIOSCIENCES,
INC. (formerly Amarillo Cell Culture Company, Incorporated), a Texas corporation
having its principal office at 800 West 9th Avenue, Amarillo, Texas 79101
(hereinafter referred to as "ABI"); and THE TEXAS A&M UNIVERSITY SYSTEM, having
its principal offices at College Station, Texas 77843 (hereinafter referred to
as "TAMUS").

                  WHEREAS, TAMUS and ABI have heretofore entered into that
certain License Agreement dated March 22, 1988 (hereinafter, the "License
Agreement"); and further

                  WHEREAS, the parties desire to amend the License Agreement 
with respect to the matters hereinafter set forth;

                  THEREFORE, in consideration of these presents and for other
good and valuable consideration the receipt and sufficiency of which are
evidenced by the execution hereof, the parties hereby agree as follows:

                  1.       All references in the License Agreement to "ACC" 
                           shall be deemed to be references to "ABI".

                  2.       The first sentence of Article 3.2 is amended by 
                           deleting the words "or any licensee".

                  3.       The following shall be inserted following the 
                           existing Article 3.2:

                           "3.2-A.  In the event ABI enters into a sublicense 
                           arrangement (as defined below), then in lieu of the 
                           royalty provided in Article 3.2


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                           above, ABI shall pay to TAMUS an earned royalty of
                           five percent (5%) of all amounts actually received by
                           ABI or its AFFILIATES with respect to the sale by any
                           sublicensee of ABI of LICENSED PRODUCTS in a country
                           where PATENT RIGHTS exist. The earned royalty
                           percentage shall be applied only once to the NET
                           SELLING PRICE regardless of the possibility that
                           manufacture, use, or sale of a LICENSED PRODUCT may
                           be covered by more than one LICENSED PATENT. For
                           purposes of this Article 3.2-A, "sublicense
                           arrangement" shall mean an arrangement under which
                           ABI and its AFFILIATES do not market LICENSED PRODUCT
                           directly, or indirectly through an agent, but rather
                           license rights to market LICENSED PRODUCT to an
                           unaffiliated entity, which entity is responsible for
                           obtaining regulatory approval in the subject market,
                           and for promotion and pricing."

                  4.       The following shall be added at the end of the
                           existing Article 3.3: ", and the royalties payable
                           under Article 3.2-A above shall be reduced to two and
                           one-half percent (2.5%) of all amounts actually
                           received by ABI or its AFFILIATES."

                  5.       The following shall be added at the end of the
                           existing Article 6.4: "; provided, however, that for
                           the license year beginning April 1, 1998, and for all
                           subsequent license years, the application of such
                           credit shall never cause the royalty provided for
                           under Article 3.4(b) to be reduced below $7,500.00
                           per year."

                  6.       Except as herein amended, all terms and provisions of
                           the License 

Agreement shall remain in full force and effect.

                  IN WITNESS WHEREOF, this Amendment has been executed by the

undersigned as of the date first above written.



AMARILLO BIOSCIENCES, INC.                      THE TEXAS A&M UNIVERSITY SYSTEM


By:                                             By:
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   Joseph M. Cummins,
   President




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