# U.S. Environmental Protection Agency October 2008

Hazard-Based Prioritization Draft

SCREENING-LEVEL HAZARD CHARACTE RIZATION AND PRIORITIZATION

ALKYL PHENOLS

8 Chemicals

HBP Subject Chemicals

CAS Registry Number CA 1 

# Index Name

91672-41-2 Phenol, 2-nonyl-, branched

134701-20-5 Phenol, 2,4-dimethyl-6-(1-methylpentadecyl)-

233587-36-5 Phenol, 2(or 4)-sec-tetracosyl234446-37-8 Phenol, 2(or 4)-sec-hexacosyl234446-38-9 Phenol, 2(or 4)-sec-octacosyl234446-39-0 Phenol, 2(or 4)-sec-triacontylSupporting Chemicals

CAS Registry Number CA 1 

# Index Name

89-72-5 Phenol, 2-(1-methylpropyl)-

84852-15-3 Phenol, 4-nonyl-, branched

Prepared by

Office of Pollution Prevention and Toxics

Environmental Protection Agency

1200 Pennsylvania Avenue, NW

Washington, DC 20460-0001

1 

# Chemical Abstracts

# U.S. Environmental Protection Agency October 2008

Hazard-Based Prioritization Draft

SCREENING-LEVEL HAZARD CHARACTE RIZATION AND PRIORITIZATION

DOCUMENT

Screening-level hazard characterizations for medium production volume chemicals are important

contributions to the chemicals coopera tion work being done in North America 2 

# through the EPA

Chemical Assessment and Management Program (ChAMP) 3 

# . This chemical cluster was

organized to maximize the potential informa tion available to inform screening-level

prioritization of chemicals needi ng further consideration and, wh ere possible, to prioritize among

multiple needs. Although most of the informati on considered relates to hazard, inferences about

exposure that can be drawn from existing enviro nmental fate and regulatory information have

also been used, and information from the 2006 Inventory Update Reporting (IUR) 4 

# is included to

inform exposure potential when it is available.

These screening-level hazard characterizations are technical documen ts intended to support

subsequent decisions and actions by Office of Pollution Preventi on and Toxics (OPPT). They

provide a vehicle for public a ccess to a concise assessment of the technical data on MPV

chemicals and provide information previously not readily available to the public. The screeninglevel hazard characterizations, as the name indi cates, do not evaluate the potential risks of a

chemical or cluster of chemicals. This initial prioritization does not c onstitute a final Agency

determination. Recommended actions may be considered by EPA in the future based on a

relative judgment regarding one or more of the chemicals in co mparison with others evaluated

under this program, and in light of the uncertainties presented by ga ps in the available data that

may be determined to exist.

The purpose of organizing chemicals into structur al clusters for this characterization was to

maximize the number of potential analogs identified for the MP V chemicals, thus maximizing

the potential data available to inform the MP V hazard characterizatio ns. Organizing each

chemical and associated data within a cluster will help assessors identify chemical trends, detect

outlying estimates and measured data, facilitate read across, assist in weight of evidence

approaches, and support identification of appropria te sub clustering. During the review of each

cluster, assessors will likely determine endpoint specific subclasses depi cting sets of compounds

with potentially similar mechanistic or biological properties within the larger structural cluster.

These endpoint specific sub clusters, breakpoints, and trends will be described within each

section of the hazar d characterization.

2 

# USEPA, U.S. Commitments to Nort h American Chemicals Cooperation:

http://www.epa.gov/hpv/pubs/general/sppframework.htm

. 3 

# USEPA, ChAMP information: http://www.epa.gov/champ/

. 4 

# USEPA, IUR Reporting information: http://www.epa.gov/oppt/iur/index.htm

.

# U.S. Environmental Protection Agency October 2008

Hazard-Based Prioritization Draft

1. STRUCTURAL CLUSTER JUSTIFICATIONS

The alkyl phenols cluster consists of eight organic compounds contai ning a phenolic hydroxyl

group substituted and substituted with branched hydro carbon chains of at least five carbons. Six

cluster members contains the hydrocarbon chain para to the hydroxyl group (phenol, 4-nonyl-,

branched, 84852-15-3; phenol, 2(or 4)-sec-tet racosyl-, 233587-36-5; phenol, 2(or 4)-sechexacosyl-, 234446-37-8; phenol, 2(or 4)-sec-oc tacosyl, 234446-38-9; phenol, 2(or 4)-sectriacontyl-, 234446-39-0; and phenol, 2,4-dimethyl-6-(1-met hylpentadecyl)-, 134701-20-5),

while two members have this substituent in the ortho position (phenol, 2-(1-methylpropyl)-, 89-

72-5 and phenol, 2-nonyl-, branched, 91672-41-2). One cluster member, phenol, 2,4-dimethyl-6-

(1-methylpentadecyl), 134701-20-5, also contains methyl groups in the 2- and 4-positions.

The following chemicals were reported in the 20 06 IUR as being manufactured in or imported to

the U.S. and are subject to this prioritization assessment:

CAS Registry Number CA Index Name

91672-41-2 Phenol, 2-nonyl-, branched

134701-20-5 Phenol, 2,4-dimethyl-6-(1-methylpentadecyl)-

233587-36-5 Phenol, 2(or 4)-sec-tetracosyl234446-37-8 Phenol, 2(or 4)-sec-hexacosyl234446-38-9 Phenol, 2(or 4)-sec-octacosyl234446-39-0 Phenol, 2(or 4)-sec-triacontylA number of the above chemicals have previ ously been reviewed in EPA’s New Chemicals

Program. The other chemicals included in this cluster are structural analogs used as supporting

chemicals to help inform the hazard characteri zation (HC) and hazard-based prioritization (HBP)

assessment.

2. PHYSICAL-CHEMICAL PROPERTIES (Table A)

Limited experimental values are available for the members of this cluster. Members are

expected to be liquids under standard temper ature and pressure conditions. The log of the

octanol/water partition coefficients (log K

ow 

# ) range from 3.28 to 3.46 for members with 15 or

fewer carbons. Estimates for those members w ith 24 or more carbons, range from 10.4 to 16.2;

although these values are outside the range of the model used to make the estimates, it can be

concluded that the log K

ow 

# for these chemicals is high. There is also a discernable breakpoint for

boiling point, vapor pressure, and water solubility. For lower molecular weight cluster members,

the boiling points range from 224 to 310oC and the vapor pressures from 0.000046 to 0.023 hPa.

The water solubility is moderate for these memb ers. For higher molecular weight members, the

boiling points range from 420 to 560oC and the vapor pressures from 4.1 ×10 -13 

# to 2.4 ×10 -8 

# hPa.

The water solubility is negligible for these clus ter members. Estimated and experimental pKas

are in a relatively narrow range of 11 to 12 for all members of this cluster.

# U.S. Environmental Protection Agency October 2008

Hazard-Based Prioritization Draft

3. ENVIRONMENTAL FATE (Table A)

One member of this cluster, phe nol, 2-(1-methylpropyl)- (89-72-5), is expected to have moderate

mobility in soil and the others are expected to have low mobility. Although estimated Henry’s

Law Constants suggest volatilizatio n of the alkylphenols from wate r is moderate, volatilization

will be mitigated by the presence of suspended solids and the chemicals tendency to partition to

organic carbon. The rate of atmospheric photooxidation for members of this cluster is

considered moderate; however, fugacity mode ling indicates that pheno l, 2-(1-methylpropyl)-

(89-72-5) will partition predominately to soil and water and to a lesser extent air and that the

remaining members will partition primarily to soil and sediment. The members of this cluster

are not expected to hydrolyze. Estimates indicate that that all members of this cluster have the

potential to biodegrade aerobically under enviro nmental conditions, although experimental and

estimated data indicate that members will not be readily biodegradable. The alkylphenols in this

cluster vary in their degree of branching which can affect the de gree and rate of biodegradation.

Therefore, although the cluster me mbers are expected to have low persistence, some may be

moderately persistent. Bioaccumulation potential is estimated to be low for all members of the

cluster.

4. AQUATIC ORGANISM TOXICITY (Table B)

All members of this cluster fall in the ECOSAR phenols class. Experimental data for phenol, 2-

(1-methylpropyl)- (89-72-5) indicates moderate acu te toxicity to aquatic invertebrates.

Experimental data for phenol, 4-nonyl-, branched (84852-15-3) indicates m oderate acute toxicity

to fish and a high acute toxicity to aquatic inve rtebrates and algae. Estimated data for phenol, 2-

nonyl-, branched (91672-41-2) indica tes high acute toxicity to fish and aquatic invertebrates and

moderate acute toxicity to algae. Chronic toxi city for cluster members with log Kow values < 6

is estimated to be high for fish, moderate to high for aquatic invertebrates, and moderate for

algae. Experimental data for phenol, 4-nonyl-b ranched corroborates the estimates of high

chronic hazard potential fo r fish. Cluster members with estimated log K

ow 

# values > 10 are

estimated not to cause acute or chronic effect s at saturation based on their very low water

solubility.

5. HUMAN HEALTH TOXICITY (Table C)

The majority of the data for assessing the mammalian toxicity of this cluster are for the

supporting chemicals, phenol, 2 -(1-methylpropyl)- (89-72-5) a nd phenol, 4-nonyl-, branched

(84852-15-3). Acute toxicity of the supporting chemicals following oral exposure (multiple

studies available) is moderate to low. Available data for th e supporting chemical, phenol, 2-(1-

methylpropyl)- (89-72-5), also in dicates low acute toxicity fo llowing dermal exposure and

moderate acute toxicity following inhalation e xposure (study summaries can be found in the

HPV Hazard Characterization for the Alkylphenols Category 5 

# ). Additional acute toxicity data

(oral and dermal in rats) submitted to EPA for a member of this cluster indicates low toxicity;

however, identifying the chemical and the submissi on in which the data were provided may be

5 

# www.epa.gov/ChAMP

# U.S. Environmental Protection Agency October 2008

Hazard-Based Prioritization Draft

confidential business information (CBI) and theref ore the data are not provided in Table C.

Repeated oral dose studies for phenol, 4- nonyl-, branched (84852-15-3) and phenol, 2,4-

dimethyl-6-(1-methylpentadecyl)- (134701-20-5) in rats also indi cate moderate to low hazard

potential for the cluster. Add itional repeated-dose data (oral exposure in ra ts) submitted to EPA

for a member of this cluster i ndicates moderate toxi city; however, identifying the chemical and

the submission in which the data were provided may be confidential business information (CBI)

and therefore the data are not prov ided in Table C. In a reproduc tive toxicity study in which rats

were exposed orally to phenol, 4-nonyl-, branched (84852-15-3), reproductiv e effects occurred at

doses indicating moderate hazard. A prenatal deve lopmental toxicity study, also conducted with

phenol, 4-nonyl-, branched (84852-15-3), showed low maternal systemic toxicity and no

developmental effects. Data for two cluster memb ers show eye and skin ir ritation in rabbits, but

negative skin sensitization in guinea pigs. Additional data submitted to EPA for a member of

this cluster indicates potential skin irritation and mild but transient eye irritation in rabbits. Data

for this chemical also indicates it causes skin sensitization in guinea pigs; however, identifying

the chemical and the submission in which the data were provided may be CBI and therefore the

data are not provide d in Table C. In vitro mutation assays conducted with phenol, 2-(1-

methylpropyl)- (89-72-5) and phenol , 4-nonyl-, branched (84852-15-3) produced negative results

in Salmonella typhimurium

, E. coli, and V79 Chinese hamster cells. Phenol, 4-nonyl-, branched

(84852-15-3) did not cause chromosome aberrations in vivo . Additional data submitted to EPA

for a member of this cluster showed negative re sults for genotoxicity in a reverse mutation assay

conducted with Salmonella typhimurium and E. coli both with and without activation; however,

identifying the chemical and the submission in which the data were provided may be CBI and

therefore the data are not provi ded in Table C. OncoLogic predicts a low potential for

carcinogenicity for all memb ers of this cluster.

6. OVERALL HAZARD CHARACTER IZATION SUMMARY (Table D)

o Persistence and Bioaccumulation : Available experimental and estimated data indicate

persistence is low for the members of this cluste r. Experimental and estimated data for seven

members of the cluster indicate that bioaccumulation potential is low.

o Environment : Available experimental and estimated da ta indicate that the overall acute and

chronic aquatic toxicity of the alkylphenols cluster is moderate to high for members with log

K

ow 

# values < 6. Members with estimated log K

ow 

# values > 10 are predicted to have no effects

at saturation.

o Human Health : Available experimental data indicate a low to moderate hazard potential for

acute and repeated-dose toxicit y. Data for phenol, 4-nonyl-, br anched (84852-15-3) indicates

a low potential for prenatal developmental toxi city and a moderate pot ential for reproductive

toxicity. The cluster members are expected to cause skin and eye irritation. At least one

cluster member is a skin sensitizer, but two ar e not. Experimental studies indicate that

members of this cluster are not likely to be genotoxic. Memb ers of this cluster are not

predicted to be carcinogenic.

# U.S. Environmental Protection Agency October 2008

Hazard-Based Prioritization Draft

7. 2006 NON-CBI IUR INFORMATION

Phenol, 2,4-dimethyl-6-(1-methylpentadecyl )- (134701-20-5); phenol, 2- nonyl-, branched

(91672-41-2): According to the 2006 Inve ntory Update Rule (IUR) submissions 6 

# , these

chemicals had aggregated producti on and/or import volume(s) in the United States between

10,000 and 500,000 pounds. No industrial processing and uses were reported in the IUR

submissions for these chemicals. Additionally, no commercial and consumer uses were reported

in the IUR submissions for these chemicals.

Phenol, 2(or 4)-sec-tetracosy l-( 233587-36-5): According to the 2006 IUR submissions, this

chemical had aggregated producti on and/or import volume(s) in the United States between

500,000 and 1 million pounds. Industrial processing and uses reported in IUR submissions for

this chemical were claimed confidential. No comm ercial and consumer uses were reported in the

IUR submissions for this chemical.

Phenol, 2(or 4)-sec-hexacosyl - (234446-37-8): According to the 2006 IUR submissions, this

chemical had aggregated producti on and/or import volume(s) in the United States between

10,000 and 500,000 pounds. Industrial processing and us es reported in IUR submissions for this

chemical were claimed confidential. No commer cial and consumer uses were reported in the

IUR submissions for this chemical.

Phenol, 2(or 4)-sec-triacontyl - (234446-39-0); phenol, 2(or 4) -sec-octacosyl- (234446-38-9):

According to the 2006 IUR submissions, each of these chemicals had aggregated production

and/or import volume(s) in the United St ates between 10,000 and 500,000 pounds. No industrial

processing and uses were reported in the IUR s ubmissions for these chemicals. Additionally, no

commercial and consumer uses were reported in the IUR submissions for these chemicals.

8. REGULATORY AND RELATED INFORMATION SUMMARY

• All cluster members ar e listed on the TSCA Inventory. Five cluster members (134701-20-5,

233587-36-5, 234446-37-8, 234446-38-9 and 234446-39-0) are commenced premanufacture

notification (PMN) substances indicating that th eir potential risks, ba sed on specified uses,

have been previously assessed by EPA’s Ne w Chemicals Program. One cluster member

(134701-20-5) is also subject to a proposed TS CA section 5(a)(2) significant new use rule

(SNUR).

• One cluster member (89-72-5) has had e xposure limits recommended by NIOSH (REL) and

ACGIH (TLV).

• EPA’s New Chemicals Program has identified “p henols” as a category with a hazard concern

of potential ecotoxicity for phenols with log K

ow 

# s below 7.4 (acute) and ~9 (chronic).

6 

# USEPA, 2006 Partial Updating of TSCA Chemical Inventory.

# U.S. Environmental Protection Agency October 2008

Hazard-Based Prioritization Draft

9. INITIAL PRIORITIZATION DECISION FOR:

CAS Registry Number CA Index Name

91672-41-2 Phenol, 2-nonyl-, branched

134701-20-5 Phenol, 2,4-dimethyl-6-(1-methylpentadecyl)-

233587-36-5 Phenol, 2(or 4)-sec-tetracosyl234446-37-8 Phenol, 2(or 4)-sec-hexacosyl234446-38-9 Phenol, 2(or 4)-sec-octacosyl234446-39-0 Phenol, 2(or 4)-sec-triacontylRationale and Uncertainties Considered in Prioritization Decision:

• The five clusters members with estimated log K

ow 

# values > 10 are estimated to have low

acute and chronic aquatic toxicity. Estimated and measured data indicate that the overall

acute and chronic aquatic toxicity for cluster members with log K

ow 

# values < 6 is moderate to

high. Therefore, information concerning uses and the frequency of re leases to water and

resultant exposures would be usef ul in determining the extent of potential concern for aquatic

organisms.

• Available data indicates moderate repeated-dose and reproductiv e toxicity, and possible skin

and eye irritation and skin sensitization. One cluster member (91672-41-2) has a vapor

pressure above 1.3 × 10 -6 

# hPa, and EPA experience has shown that worker exposure to

vapors have been a concern for chemicals with vapor pressures above th at value. Exposurerelated information would be useful to more co mpletely assess human health concerns for the

cluster members.

• EPA’s review of that cluster member (134701- 20-5) in the New Chemical Program resulted

in development of a proposed non-section 5e SNUR which defined any use leading to

releases of water or lack of appropriate protection in the wo rkplace as a new use requiring

EPA notification. These regulatory decisions ma y be relevant for other cluster members.

Prioritization Decision:

MEDIUM PRIORITY: consider whether concern s expressed in the SNUR proposed for

one cluster member should be applied to ot her cluster members after reviewing use and

exposure information for the one cluster me mber (91672-41-2) not reviewed in the New

Chemicals Program.

• Recognizing the potential concerns for ecotoxicity and human health effects, the one cluster

member (91672-41-2) not reviewed under the Ne w Chemicals Program should be referred to

the Interagency Testing Committee (ITC) as a candidate for the co llection of exposurerelated information and unpublishe d health and safety studies.

• EPA should evaluate the cluster members agai nst the concerns expressed in the SNUR

proposed under TSCA section 5(a)(2) for a cluster member (134701-20-5), and consider

whether comparable (or other) actions may be needed for additional cluster members.If no units provided - endpoint is unitlessTable AP-Chem Properties and Environmental FateAlkyl phenols (8)CASRN89-72-5 91672-41-2 84852-15-3 134701-20-5 233587-36-5 234446-37-8 234446-38-9 234446-39-0ChemicalPhenol, 2-(1-methylpropyl)-Phenol, 2-nonyl-,branchedPhenol, 4-nonyl-,branchedPhenol, 2,4-dimethyl-6-(1-methylpentadecyl)-Phenol, 2(or4)-sectetracosylPhenol, 2(or4)-sec-hexacosyl-Phenol, 2(or4)-sec-octacosyl-Phenol, 2(or4)-sec-triacontylMolecularWeight150.22 220.36 220.36 346.6 430.76 458.82 486.87 514.93ProductionVolumeStateLiquid LiquidMelting Point(oC)1425Boiling Point(oC)224300310420490520540560VaporPressure (hPaat 25oC0.0230.000340.0000460.0000000240.000000000120.0000000000180.00000000000280.00000000000041WaterSolubility(mg/L)170021014000.000030.0000000340.00000000330.000000000320.00000000003log Kow3.463.283.2810.413.314.315.316.2Koc26004100040000110000005300000001800000000610000000010000000000pKA/pKB111111.061212121212HLC (atmm3/mole)0.00000210.0000170.0000170.000150.00210.00420.00850.017HydrolysisPhotolysisPhotooxidation(half-life days)0.240.210.210.250.150.140.140.13Readily BiodegNoNoNoNoNoNoNoNoRapid BiodegYesYesYesYesYesYesYesYesUltimateBiodegweeksweeks-monthsweeks-monthsweeks-monthsweeks-monthsweeks-monthsweeks-monthsweeks-monthsOther BiodegOther FateFugacityAir (%)0.560.240.2400000Water (%)2518181.81.81.81.81.9Soil (%)7481813030303030Sediment(%)0.690.760.766868686868BCF1667673.23.23.23.23.2BAFTable BAquatic ToxicityAlkyl phenols (8)CASRN89-72-5 91672-41-2 84852-15-3 134701-20-5 233587-36-5 234446-37-8 234446-38-9 234446-39-0ChemicalPhenol, 2-(1-methylpropyl)-Phenol, 2-nonyl-,branchedPhenol, 4-nonyl-,branchedPhenol, 2,4-dimethyl-6-(1-methylpentadecyl)-Phenol, 2(or4)-sectetracosylPhenol, 2(or4)-sec-hexacosyl-Phenol, 2(or4)-sec-octacosyl-Phenol, 2(or4)-sec-triacontylMolecular Weight150.22 220.36 220.36 346.6 430.76 458.82 486.87 514.93Production VolumeStateLiquid LiquidACUTEFish (mg/L)2.60.0570.130.000034(NES)0.00000035(NES)0.000000072(NES)0.000000015(NES)0.0000000029(NES)FreshwaterfishFreshwaterfishPimephalespromelasFreshwaterfishFreshwaterfishFreshwaterfishFreshwaterfishFreshwaterfish96h LC5096h LC5096h LC5096h LC5096h LC5096h LC5096h LC5096h LC50PhenolsPhenolsPhenolsPhenolsPhenolsPhenolsPhenolsInvertebrate(mg/L)1.30.0840.0850.0003(NES)0.0000091(NES)0.0000027(NES)0.00000079(NES)0.00000023(NES)CrangonseptemspinosaDaphniamagnaDaphniamagnaDaphniamagnaDaphniamagnaDaphniamagnaDaphniamagnaDaphniamagna96h LC5048h LC5048h EC5048h LC5048h LC5048h LC5048h LC5048h LC50PhenolsPhenolsPhenolsPhenolsPhenolsPhenolsAlgae (mg/L)6.10.270.05630.0006(NES)0.000014(NES)0.0000038(NES)0.000001(NES)0.00000027(NES)Green AlgaeGreen AlgaeScenedesmussubspicatusGreen AlgaeGreen AlgaeGreen AlgaeGreen AlgaeGreen Algae96h EC5096h EC5072h EC5096h EC5096h EC5096h EC5096h EC5096h EC50PhenolsPhenolsPhenolsPhenolsPhenolsPhenolsPhenolsCHRONICFish (mg/L)0.0040.0060.0140.000034(NES)0.00000085(NES)0.00000023(NES)0.000000064(NES)0.000000018(NES)FreshwaterfishFreshwaterfishPimephalespromelasFreshwaterfishFreshwaterfishFreshwaterfishFreshwaterfishFreshwaterfish60d ChV60d ChV33d LOEC30d ChV30d ChV30d ChV30d ChV30d ChVPhenolsPhenolsPhenolsPhenolsPhenolsPhenolsPhenolsInvertebrate(mg/L)0.280.0160.0240.000056(NES)0.0000017(NES)0.0000005(NES)0.00000015(NES)0.000000043(NES)DaphniamagnaDaphniamagnaDaphniamagnaDaphniamagnaDaphniamagnaDaphniamagnaDaphniamagnaDaphniamagna21d ChV21d ChV21d NOEC21d ChV21d ChV21d ChV21d ChV21d ChVPhenolsPhenolsPhenolsPhenolsPhenolsPhenolsPhenolsAlgae (mg/L)2.80.124.10.00025(NES)0.0000057(NES)0.0000015(NES)0.0000004(NES)0.00000011(NES)Green AlgaeGreen AlgaeGreen AlgaeGreen AlgaeGreen AlgaeGreen AlgaeGreen AlgaeGreen AlgaeChVChVChVChVChVChVChVChVPhenolsPhenolsPhenolsPhenolsPhenolsPhenolsPhenolsPhenolsTable CHuman HealthAlkyl phenols (8)CASRN89-72-591672-41-284852-15-3134701-20-5233587-36-5234446-37-8234446-38-9234446-39-0ChemicalPhenol, 2-(1-methylpropyl)-Phenol, 2-nonyl-,branchedPhenol, 4-nonyl-,branchedPhenol, 2,4-dimethyl-6-(1-methylpentadecyl)-Phenol, 2(or4)-sectetracosylPhenol, 2(or4)-sec-hexacosyl-Phenol, 2(or4)-sec-octacosyl-Phenol, 2(or4)-sec-triacontylMolecular Weight150.22 220.36 220.36 346.6 430.76 458.82 486.87 514.93ProductionVolumeStateLiquid LiquidAcute320mg/kg1882mg/kgRatRatRepeat Dose150mg/kg/day200mg/kg/dayRatRat90d28dReproductive52.3mg/kg/dayRat6w/pm/3 genDevelopmental150mg/kg/dayRatGD 6-15GenotoxicityCancerEye IrritationRabbitSkin IrritationRabbitRabbitSkin SensitizationGuinea PigOther ToxicityTable DOverall Hazard CharacterizationAlkyl phenols (8)CASRN 89-72-5 91672-41-2 84852-15-3 134701-20-5 233587-36-5 234446-37-8 234446-38-9 234446-39-0ChemicalPhenol, 2-(1-methylpropyl)-Phenol, 2-nonyl-,branchedPhenol, 4-nonyl-,branchedPhenol, 2,4-dimethyl-6-(1-methylpentadecyl)-Phenol, 2(or4)-sectetracosylPhenol, 2(or4)-sec-hexacosyl-Phenol, 2(or4)-sec-octacosyl-Phenol, 2(or4)-sec-triacontylMolecular Weight150.22 220.36 220.36 346.6 430.76 458.82 486.87 514.93Production VolumeStateLiquid LiquidEnvironmentalPersistenceBioaccumulationAquatic ToxicityAcuteChronicHuman HealthEffectsAcute ToxicityRepeated-DoseReproductiveDevelopmentalGenotoxicityCancer HazardEye IrritationSkin IrritationSkin Sensitization

# PCHEM/FATE

Melting Point

89725 USEPA-HPV-Hazard Characterization

84852153 USEPA-HPV-Hazard Characterization



# Boiling Point

89725 USEPA-HPV-Hazard Characterization

84852153 USEPA-HPV-Hazard Characterization

91672412 

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# Vapor Pressure

89725 USEPA-HPV-Hazard Characterization

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# Water Solubility

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# Log Kow

89725 USEPA-HPV-Hazard Characterization

84852153 USEPA-HPV-Hazard Characterization

91672412 Read-Across from 84852153

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# Koc

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# pKa/pKb

89725 SPARC Online Calculator v4.2

84852153 EFDB

91672412 SPARC Online Calculator v4.2

134701205 SPARC Online Calculator v4.2

233587365 SPARC Online Calculator v4.2

234446378 SPARC Online Calculator v4.2

234446389 SPARC Online Calculator v4.2

234446390 SPARC Online Calculator v4.2



# Henry's Law Constant

89725 EPI v3.2 2007

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# Photooxidation

89725 EPI v3.2 2007

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91672412 EPI v3.2 2007

134701205 EPI v3.2 2007

233587365 EPI v3.2 2007

234446378 EPI v3.2 2007

234446389 EPI v3.2 2007

234446390 EPI v3.2 2007



# Ready Biodegradation

89725 USEPA-HPV-Hazard Characterization

84852153 USEPA-HPV-Hazard Characterization

91672412 EPI v3.2 2007

134701205 EPI v3.2 2007

233587365 EPI v3.2 2007

234446378 EPI v3.2 2007

234446389 EPI v3.2 2007

234446390 EPI v3.2 2007



# Rapid Biodegradation

# 89725 EPI v3.2 2007

84852153 EPI v3.2 2007

91672412 EPI v3.2 2007

134701205 EPI v3.2 2007

233587365 EPI v3.2 2007

234446378 EPI v3.2 2007

234446389 EPI v3.2 2007

234446390 EPI v3.2 2007



# Ultimate Biodegradation

89725 EPI v3.2 2007

84852153 EPI v3.2 2007

91672412 EPI v3.2 2007

134701205 EPI v3.2 2007

233587365 EPI v3.2 2007

234446378 EPI v3.2 2007

234446389 EPI v3.2 2007

234446390 EPI v3.2 2007



# Fugacity

89725 EPI v3.2 2007

84852153 EPI v3.2 2007

91672412 EPI v3.2 2007

134701205 EPI v3.2 2007

233587365 EPI v3.2 2007

234446378 EPI v3.2 2007

234446389 EPI v3.2 2007

234446390 EPI v3.2 2007



# BCF

89725 Japan’s Ministry of Economy, Trade, and Industry’s MITI Biodegradation Database

84852153 EPI v3.2 2007

91672412 

# Read across from CA SRN 84852-15-3.

134701205 EPI v3.2 2007

233587365 EPI v3.2 2007

234446378 EPI v3.2 2007

234446389 EPI v3.2 2007

234446390 EPI v3.2 2007



# ECOTOXICITY

Acute Fish

89725 ECOSAR v.1.00

84852153 USEPA-HPV

91672412 ECOSAR v.1.00

134701205 ECOSAR v.1.00

233587365 ECOSAR v.1.00

234446378 ECOSAR v.1.00

# 234446389 ECOSAR v.1.00

234446390 ECOSAR v.1.00



# Acute Daphnid

89725 USEPA-HPV

84852153 USEPA-HPV

91672412 ECOSAR v.1.00

134701205 ECOSAR v.1.00

233587365 ECOSAR v.1.00

234446378 ECOSAR v.1.00

234446389 ECOSAR v.1.00

234446390 ECOSAR v.1.00



# Acute Algae

89725 ECOSAR v.1.00

84852153 USEPA-HPV

91672412 ECOSAR v.1.00

134701205 ECOSAR v.1.00

233587365 ECOSAR v.1.00

234446378 ECOSAR v.1.00

234446389 ECOSAR v.1.00

234446390 ECOSAR v.1.00



# Chronic Fish

89725 ECOSAR v.1.00

84852153 USEPA-HPV

91672412 ECOSAR v.1.00

134701205 ECOSAR v.1.00

233587365 ECOSAR v.1.00

234446378 ECOSAR v.1.00

234446389 ECOSAR v.1.00

234446390 ECOSAR v.1.00



# Chronic Daphnid

89725 ECOSAR v.1.00

84852153 USEPA-HPV

91672412 ECOSAR v.1.00

134701205 ECOSAR v.1.00

233587365 ECOSAR v.1.00

234446378 ECOSAR v.1.00

234446389 ECOSAR v.1.00

234446390 ECOSAR v.1.00



# Chronic Algae

89725 ECOSAR v.1.00

84852153 ECOSAR v.1.00

91672412 ECOSAR v.1.00

134701205 ECOSAR v.1.00

# 233587365 ECOSAR v.1.00

234446378 ECOSAR v.1.00

234446389 ECOSAR v.1.00

234446390 ECOSAR v.1.00



# HUMAN HEALTH

Acute Toxicity

89725 ChemIDPlus

84852153 USEPA-HPV`



# Repeat Dose

84852153 USEPA-HPV

134701205 USEPA-TSCATS section 8E



# Reproductive

84852153 USEPA-HPV



# Developmental

84852153 USEPA-HPV



# Genotoxicity

89725 USEPA-HPV

84852153 USEPA-HPV



# Cancer

89725 OncoLogic

84852153 OncoLogic

91672412 OncoLogic

134701205 OncoLogic

233587365 OncoLogic

234446378 OncoLogic

234446389 OncoLogic

234446390 OncoLogic



# Eye Irritation

84852153 USEPA-HPV



# Skin Irritation

89725 USEPA-HPV

84852153 USEPA-HPV



# Skin Sensitization

84852153 USEPA-HPV