Exhibit 10.4



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INVESTMENT AGREEMENT



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Between



CORAUTUS GENETICS INC.



and



BOSTON SCIENTIFIC
CORPORATION



Dated as of June 27, 2005



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TABLE OF CONTENTS



|                                                         |  |                                                                  |  |     
|-------------------------------------------------------- |  | ---------------------------------------------------------------- |  | ----
|                                                         |  |                                                                  |  | Page
|ARTICLE 1 DEFINITIONS                                    |  | 2                                                               
|1.1                                                      |  | CERTAIN DEFINED TERMS                                            |  | 2   
|1.2                                                      |  | ADDITIONAL DEFINITIONS                                           |  | 4   
|                                                         | 
|ARTICLE 2 EQUITY INVESTMENT                              |  | 5                                                               
|                                                         |  |                                                                 
|2.1                                                      |  | SUBSCRIPTION FOR COMMON STOCK                                    |  | 5   
|2.2                                                      |  | THE CLOSING                                                      |  | 6   
|                                                         | 
|ARTICLE 3 REPRESENTATIONS AND WARRANTIES OF THE COMPANY  |  | 7                                                               
|                                                         |  |                                                                 
|3.1                                                      |  | ORGANIZATION, AUTHORITY AND QUALIFICATION OF THE COMPANY         |  | 7   
|3.2                                                      |  | SUBSIDIARIES                                                     |  | 7   
|3.3                                                      |  | CAPITAL STOCK OF THE COMPANY                                     |  | 8   
|3.4                                                      |  | AUTHORITY AND QUALIFICATION OF THE COMPANY                       |  | 8   
|3.5                                                      |  | NO CONFLICT                                                      |  | 9   
|3.6                                                      |  | GOVERNMENTAL CONSENTS AND APPROVALS                              |  | 9   
|3.7                                                      |  | ABSENCE OF CERTAIN CHANGES OR EVENTS; CONDUCT IN
ORDINARY COURSE |  | 9   
|3.8                                                      |  | SEC FILINGS; FINANCIAL STATEMENTS                                |  | 9   
|3.9                                                      |  | LITIGATION                                                       |  | 11  
|3.10                                                     |  | COMPLIANCE WITH LAWS                                             |  | 11  
|3.11                                                     |  | ASSETS                                                           |  | 11  
|3.12                                                     |  | BROKERS                                                          |  | 11  
|3.13                                                     |  | EMPLOYMENT AND BENEFITS MATTERS                                  |  | 11  
|3.14                                                     |  | INSURANCE                                                        |  | 11  
|3.15                                                     |  | REGULATORY COMPLIANCE                                            |  | 12  
|3.16                                                     |  | ABSENCE OF UNDISCLOSED LIABILITIES                               |  | 12  
|3.17                                                     |  | FULL DISCLOSURE                                                  |  | 12  
|3.18                                                     |  | CLINICAL TRIALS; PRODUCT DATA                                    |  | 12  
|3.19                                                     |  | NASDAQ                                                           |  | 13  
|                                                         | 
|ARTICLE 4 REPRESENTATIONS AND WARRANTIES OF THE INVESTOR |  | 13                                                              
|                                                         |  |                                                                 
|4.1                                                      |  | ORGANIZATION AND AUTHORITY OF THE INVESTOR                       |  | 13  
|4.2                                                      |  | NO CONFLICT                                                      |  | 13  
|4.3                                                      |  | GOVERNMENTAL CONSENTS AND APPROVALS                              |  | 14  
|4.4                                                      |  | BROKERS                                                          |  | 14  
|4.5                                                      |  | ACCREDITED INVESTOR AND INVESTMENT EXPERIENCE                    |  | 14  
|4.6                                                      |  | INVESTMENT INTENT                                                |  | 14  
|4.7                                                      |  | INFORMATION AND RISK.                                            |  | 14  
|4.8                                                      |  | LEGENDS                                                          |  | 15  
|                                                         | 
|ARTICLE 5 COVENANTS AND AGREEMENTS                       |  | 15                                                              
|                                                         |  |                                                                 
|5.1                                                      |  | CONDUCT OF BUSINESS                                              |  | 15  
|5.2                                                      |  | GOVERNMENTAL PROCEEDINGS                                         |  | 15  
|5.3                                                      |  | LISTING                                                          |  | 15  
|5.4                                                      |  | WAIVER OF ANTIDILUTION RIGHTS                                    |  | 15  
|                                                         | 
|ARTICLE 6 USE OF PROCEEDS                                |  | 16                                                              
|                                                         |  |                                                                 
|6.1                                                      |  | RESEARCH AND DEVELOPMENT                                         |  | 16  
|                                                         | 
|ARTICLE 7 CONDITIONS PRECEDENT                           |  | 16                                                              
|                                                         |  |                                                                 
|7.1                                                      |  | CONDITIONS TO THE INVESTORS OBLIGATIONS                         |  | 16  
|7.2                                                      |  | CONDITIONS TO THE COMPANYS OBLIGATIONS                          |  | 17  



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|                              |  |                                                         |  |   
|----------------------------- |  | ------------------------------------------------------- |  | --
|ARTICLE 8 INDEMNIFICATION     |  | 18                                                     
|                              |  |                                                        
|8.1                           |  | SURVIVAL OF REPRESENTATIONS, WARRANTIES AND INDEMNITIES |  | 18
|8.2                           |  | INDEMNIFICATION BY THE COMPANY                          |  | 18
|8.3                           |  | INDEMNIFICATION BY THE INVESTOR                         |  | 18
|8.4                           |  | TREATMENT FOR TAX PURPOSES                              |  | 19
|8.5                           |  | LIMITATIONS ON INDEMNIFICATION                          |  | 19
|                              | 
|ARTICLE 9 TERMINATION         |  | 19                                                     
|                              |  |                                                        
|9.1                           |  | TERMINATION                                             |  | 19
|9.2                           |  | EFFECT OF TERMINATION                                   |  | 20
|                              | 
|ARTICLE 10 CONFIDENTIALITY    |  | 20                                                     
|                              |  |                                                        
|10.1                          |  | CONFIDENTIALITY                                         |  | 20
|10.2                          |  | RELEASE FROM RESTRICTIONS                               |  | 20
|10.3                          |  | PUBLIC ANNOUNCEMENTS AND PUBLICATIONS                   |  | 21
|                              | 
|ARTICLE 11 GENERAL PROVISIONS |  | 21                                                     
|                              |  |                                                        
|11.1                          |  | FURTHER ACTION                                          |  | 21
|11.2                          |  | EXPENSES                                                |  | 21
|11.3                          |  | NOTICES                                                 |  | 21
|11.4                          |  | INTERPRETATION AND RULES OF CONSTRUCTION                |  | 22
|11.5                          |  | SEVERABILITY                                            |  | 23
|11.6                          |  | ENTIRE AGREEMENT                                        |  | 23
|11.7                          |  | ASSIGNMENT                                              |  | 23
|11.8                          |  | NO THIRD PARTY BENEFICIARIES                            |  | 24
|11.9                          |  | AMENDMENT                                               |  | 24
|11.10                         |  | NO WAIVER                                               |  | 24
|11.11                         |  | DISPUTE RESOLUTION                                      |  | 24
|11.12                         |  | GOVERNING LAW                                           |  | 24
|11.13                         |  | COUNTERPARTS                                            |  | 25
|11.14                         |  | WAIVER OF JURY TRIAL                                    |  | 25
|11.15                         |  | CONSTRUCTION; INTERPRETATION                            |  | 25
|11.16                         |  | SPECIFIC PERFORMANCE                                    |  | 25



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EXHIBITS AND SCHEDULES



|                    |  |                                                         
|------------------- |  | --------------------------------------------------------
|Exhibit A           |  | Form of Registration Rights Agreement                   
|Exhibit B           |  | Form of Amendment to Loan Agreement                     
|Exhibit C           |  | Form of Amendment to Distribution Agreement             
|Exhibit D           |  | Form of Escrow Agreement                                
|Exhibit E           |  | Form of Instructions to Transfer Agent                  
|Exhibit F           |  | Form of Amendment to Series D Certificate of Designation
|Exhibit G           |  | Form of Legal Opinion                                   
|                   
|Disclosure Schedule



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INVESTMENT AGREEMENT



THIS INVESTMENT AGREEMENT, dated as of June 27, 2005 (the Signing Date), between CORAUTUS GENETICS INC.,
a Delaware corporation (the Company), and BOSTON SCIENTIFIC CORPORATION, a Delaware corporation (the Investor, each a Party and together with the Company, the Parties).



WHEREAS, the Investor is an existing shareholder of the
Company and is engaged in the business of developing, manufacturing and marketing, among other things, biomedical technology used to treat cardiac and vascular disease;



WHEREAS, the Company wishes to pursue the development and distribution of drugs or products that use VEGF-2 for the
treatment of the heart or peripheral vascular system (the Products);



WHEREAS, the Investor is willing to subscribe for additional capital stock of the Company to provide funding to the Company for purposes of such development and to increase its ownership interest in the Company;



WHEREAS, on the Closing Date, the Parties are entering into a
Registration Rights Agreement, substantially in the form of Exhibit A, to provide, among other things, for certain registration rights of the Investor in connection with its purchase of capital stock of the Company hereunder (the
Registration Rights Agreement);



WHEREAS, on
the Closing Date, the Company and the Investor will also be entering into (i) an amendment to the Loan Agreement dated as of July 30, 2003, as amended, between the Parties, which amendment shall be substantially in the form of Exhibit B (the
Loan Agreement Amendment), (ii) an amendment to the Distribution Agreement dated as of July 30, 2003 between the Parties (the Distribution Agreement), which amendment shall be substantially in the form of
Exhibit C (the Distribution Agreement Amendment), and (iii) an Escrow Agreement, substantially in the form of Exhibit D, to provide for the escrow of the Investors purchase price for the shares purchased
hereunder until such time as the Company has obtained shareholder approval for the issuance of such shares (the Escrow Agreement) (this Agreement, the Registration Rights Agreement, the Loan Agreement Amendment, the Distribution
Agreement Amendment and the Escrow Agreement are hereinafter collectively referred to as the Transaction Documents), all of which are a material consideration in the willingness of the Investor to provide the funding contemplated
by this Agreement;



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NOW, THEREFORE, in consideration of the premises and the mutual representations and warranties,
agreements and covenants hereinafter set forth, the Parties hereby agree as follows:



ARTICLE 1



DEFINITIONS



1.1 Certain Defined Terms



For purposes of this Agreement:



Action means any claim, action, suit, arbitration,
inquiry, proceeding or investigation by or before any Governmental Authority.



Affiliate means, with respect to any specified Person, any other Person that directly, or indirectly through one or more intermediaries, controls, is controlled by, or is under common control with,
such specified Person.



Agreement or
this Agreement means this Agreement and includes the Exhibits and the Disclosure Schedule, and all amendments hereto made in accordance with the provisions of Section 11.9.



Board of Directors means the board of directors of the
Company.



Business Day means any day that is
not a Saturday, a Sunday or any other day on which banks are required or authorized by Law to be closed in The City of New York.



Common Stock means the common stock of the Company, par value $0.001 per share.



Confidential Information means all nonpublic proprietary
information and materials (whether or not patentable), disclosed by a Disclosing Party to a Receiving Party, irrespective of the manner in which the Disclosing Party disclosed such information to the Receiving Party, in furtherance of this
Agreement, including, without limitation, substances, formulations, techniques, methodologies, equipment, data, reports, correspondence, know-how, manufacturing documentation, financial information and sources of supply.



control (including the terms controlled
by and under common control with), with respect to the relationship between or among two or more Persons, means the possession, directly or indirectly or as trustee, personal representative or executor, of the power to
direct or cause the direction of the affairs or management of a Person, whether through the ownership of voting securities, as trustee, personal representative or executor, by contract, credit arrangement or otherwise.



Disclosing Party means a Party disclosing Confidential
Information.



Disclosure Schedule means the
Disclosure Schedule attached hereto, dated as of the date hereof and forming a part of this Agreement.



Encumbrance means any security interest, pledge, hypothecation, mortgage, lien (including, without limitation, environmental and Tax
liens) or other encumbrance.



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ERISA means the Employee Retirement Income Security Act of 1974, as amended from time
to time, and the regulations promulgated and rulings issued thereunder.



FDA means the United States Food and Drug Administration.



Governmental Authority means any United States or non-United States federal, national, supranational, state, provincial, local, or similar government, governmental, regulatory or administrative
authority, agency or commission or any court, tribunal, or judicial or arbitral body.



Governmental Order means any order, writ, judgment, injunction, decree, stipulation, determination or award entered by or with any Governmental Authority.



Law means any United States or non-United States federal,
national, supranational, state, provincial, local or similar statute, law, ordinance, regulation, rule, code, order, requirement or rule of law.



Material Adverse Effect means any circumstance, change or effect that, individually or in the aggregate with all other circumstances,
changes or effects: (a) is or is reasonably likely to be materially adverse to the business, assets, operations, results of operations, prospects, liabilities (including, without limitation, contingent liabilities) or the financial condition of the
Company and its Subsidiaries, taken as a whole or (b) is reasonably likely to materially adversely effect the ability of the Company to consummate the transactions contemplated by this Agreement and the other Transaction Documents.



Person means any individual, partnership, firm,
corporation, limited liability company, association, trust, unincorporated organization or other entity, as well as any syndicate or group that would be deemed to be a person under Section 13(d)(3) of the Securities Exchange Act of 1934, as amended.



Plan means any (a) employee benefit plans
(as defined in Section 3(3) of ERISA) and all bonus, stock option, stock purchase, restricted stock, incentive, deferred compensation, retiree medical or life insurance, supplemental retirement, severance or other benefit plans, programs or
arrangements, and all employment, termination, severance or other contracts or agreements to which the Company or any Subsidiary is a party, with respect to which the Company or any Subsidiary has any obligation, or which is maintained, contributed
to or sponsored by the Company or any Subsidiary for the benefit of any current or former employee, officer or director of the Company or any Subsidiary, (b) employee benefit plan for which the Company or any Subsidiary could incur liability under
Section 4069 of ERISA in the event such plan has been or were to be terminated, or (c) plan in respect of which the Company or any Subsidiary could incur liability under Section 4212(c) of ERISA.



Receiving Party means a Party receiving Confidential
Information.



Subsidiary of any Person means
any corporation, partnership, joint venture, limited liability company, trust or estate of which (or in which) more than 50% of (a) the issued and outstanding capital stock having ordinary voting power to elect a majority of the board of directors
of such corporation (irrespective of whether at the time capital stock of any other class



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or classes of such corporation shall or might have voting power upon the occurrence of any contingency), (b) the interest
in the capital or profits of such limited liability company, partnership, or joint venture or (c) the beneficial interest in such trust or estate is at the time directly or indirectly owned or controlled by such Person, by such Person and one or
more of its other Subsidiaries or by one or more of such Persons other Subsidiaries.



Tax or Taxes means all income, gross receipts, gains, sales, use, employment, franchise, profits, excise, property, value added and other taxes, fees, stamp taxes and duties,
assessments or charges of any kind, together with any interest and penalties, additions to tax or additional amounts imposed by any taxing authority with respect thereto.



U.S. GAAP means United States generally accepted accounting principles applied on a consistent basis.



VEGF-2 means the Human Genome Sciences
angiogenic agent licensed to and being further developed and modified by the Company, sometimes referred to as Vascular Endothelial Growth Factor 2 plasmid DNA, and any modifications or improvements thereto.



VGI means Vascular Genetics Inc., a Delaware corporation.



1.2 Additional Definitions



The following terms have the meanings set forth in the Sections set forth
below:



|                                   |  |         
|---------------------------------- |  | --------
|Definition                         |  | Location
|Assets                           |  | 3.11    
|Closing                          |  | 2.2(a)  
|Closing Date                     |  | 2.2(a)  
|Company                          |  | Preamble
|Company Financial Statements     |  | 3.8(b)  
|Company Indemnified Party        |  | 8.3     
|Company SEC Reports              |  | 3.8(a)  
|Distribution Agreement           |  | Recitals
|Distribution Agreement Amendment |  | Recitals
|Escrow Agent                     |  | 2.1(c)  
|Escrow Agreement                 |  | Recitals
|Escrowed Funds                   |  | 2.1(c)  
|Exchange Act                     |  | 3.8(a)  
|Investor                         |  | Preamble
|Investor Indemnified Party       |  | 8.2     
|Loan Agreement Amendment         |  | Recitals
|Loss                             |  | 8.2     
|NASDAQ                           |  | 3.19    
|Notice of Disagreement           |  | 11.11   
|Parties                          |  | Preamble
|Party                            |  | Preamble



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|                                |  |         
|------------------------------- |  | --------
|Definition                      |  | Location
|Preferred Stock               |  | 3.3     
|Products                      |  | Recitals
|Reference Statement Date      |  | 3.8(c)  
|Registration Rights Agreement |  | Recitals
|SEC                           |  | 3.8(a)  
|Securities Act                |  | 3.8(a)  
|Signing Date                  |  | Preamble
|Threshold Amount              |  | 8.5     
|Transaction Documents         |  | Recitals



ARTICLE 2



EQUITY INVESTMENT



2.1 Subscription for Common Stock



(a) Subscription. Upon the basis of the representations and
warranties set forth in this Agreement and subject to the terms and conditions set forth herein and in the Escrow Agreement, the Investor agrees to subscribe for, and the Company agrees to issue and sell to the Investor, 2,105,264 shares of Common
Stock of the Company.



(b) Consideration. In
consideration for the issuance to the Investor of such shares of Common Stock, the Investor shall pay $8,000,003.20(Eight Million Three and 20/100 Dollars) to the Company as provided in Section 2.1(c) below.



(c) Escrow. At the Closing, the Investor shall deliver the entire purchase price of $8,000,003.20(the Escrowed Funds) to Wachovia Bank,
National Association (the Escrow Agent), to be held by the Escrow Agent in escrow. Upon the approval by the Companys shareholders of the sale and issuance of the purchased shares to the Investor, (i) the Company shall
provide the Investor and the Escrow Agent with a certificate from a duly authorized officer certifying on behalf of the Company that such approval has been obtained, (ii) the Company shall provide the Investor with an instruction letter to the
transfer agent of the Company in substantially the form of Exhibit E attached hereto, (iii) the Company shall provide the Investor an opinion of counsel in substantially the form of Exhibit G attached hereto, and (iv) the Escrow Agent
shall release the Escrowed Funds to the Company, as provided in the Escrow Agreement, by wire transfer of immediately available funds to a bank account designated by the Company for such purpose. In the event that the Companys shareholders do
not approve the sale and issuance of the purchased shares to the Investor on or before June 1, 2006, the Escrow Agent shall return the Escrow Funds to the Investor as provided in the Escrow Agreement, and the Parties shall have no further
obligations or liability with respect to the sale, purchase or issuance of the shares to be purchased hereunder, including all rights with respect thereto under the Registration Rights Agreement.



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2.2 The Closing



(a) Subject to the terms and conditions of this Agreement, the closing of the transactions contemplated by Section 2.1 of
this Agreement shall take place at a closing (the Closing) to be held at the offices of McKenna Long & Aldridge LLP, 303 Peachtree Street, NE, Suite 5300, Atlanta, Georgia at 10:00 A.M. (Atlanta time) on June 27, 2005, or at
such other time and place that the Company and the Investor shall agree (the Closing Date).



(b) Closing Deliveries of the Company. At the Closing, the Company shall deliver or cause to be delivered to the Investor:



(1) the Transaction Documents, duly executed by the Company;



(2) a true and complete copy, certified by the Secretary of the Company, of
the resolutions duly and validly adopted by the Board of Directors evidencing its authorization of the execution and delivery of the Transaction Documents and the consummation of the transactions contemplated thereby, accompanied by the
certification of the Secretary of the Company as to the names and signatures of the officers of the Company authorized to sign the Transaction Documents and the other documents to be delivered thereunder;



(3) a copy of (A) the restated certificate of incorporation of the Company,
as amended, certified by the Secretary of State of the State of Delaware, as of a date not earlier than ten (10) Business Days prior to the Closing Date and accompanied by a certificate of the Secretary of the Company, dated as of the Closing Date,
stating that no amendments have been made to such restated certificate of incorporation since such date, and (B) the by-laws of the Company, certified by the Secretary of the Company;



(4) a good standing certificate for the Company issued by the Secretary of State of the State of Delaware, dated as of a
date not earlier than ten (10) Business Days prior to the Closing Date; and



(5) the certificate, dated as of the Closing Date, contemplated by Section 7.1(a).



(c) Closing Deliveries of the Investor. At the Closing Date, the Investor shall deliver or cause to be delivered to the Company:



(1) a receipt evidencing that the sum of $8,000,003.20has been deposited with the Escrow Agent to be held in escrow
in accordance with the terms of the Escrow Agreement;



(2) the Transaction Documents, duly executed by the Investor; and



(3) the certificate, dated the Closing Date, contemplated by Section 7.2(a).



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ARTICLE 3



REPRESENTATIONS AND WARRANTIES

OF
THE COMPANY



As an inducement to the Investor to enter into
this Agreement and the other Transaction Documents, the Company hereby represents and warrants to the Investor as of the date hereof and as of the Closing Date (except for such representations and warranties as are expressly made as of another date)
as follows (it being understood that for purposes of the Disclosure Schedule, matters that are disclosed in one Section of the Disclosure Schedule are considered to be disclosed in another Section of the Disclosure Schedule to the extent that the
Disclosure Schedule contains cross-references that make the relevance of such information to such other Section reasonably apparent):



3.1 Organization, Authority and Qualification of the Company



The Company is a corporation duly organized, validly existing and in good standing under the Laws of the State of Delaware
and has all necessary corporate power and authority to own, operate or lease the properties and assets now owned, operated or leased by it and to carry on its business as it has been and is currently conducted. The Company is duly licensed or
qualified to do business and is in good standing in each jurisdiction in which the properties owned or leased by it or the operation of its business makes such licensing or qualification necessary, except where the failure to be so licensed or
qualified would not (a) materially adversely affect the ability of the Company to carry out its obligations under, and to consummate the transactions contemplated by this Agreement and the other Transaction Documents or (b) otherwise have a Material
Adverse Effect.



3.2 Subsidiaries



(a) Other than Urogen Acquisition Corporation and VGI, there are no other
corporations, partnerships, joint ventures, associations or other entities in which the Company or any Subsidiary thereof owns, of record or beneficially, any direct or indirect equity or other interest or any right (contingent or otherwise) to
acquire the same. Neither the Company nor either of its two Subsidiaries is a member of (nor is any part of their business conducted through) any partnership nor is the Company or either Subsidiary a participant in any joint venture or similar
arrangement.



(b) Each of the Companys two Subsidiaries:
(i) is duly organized, validly existing and in good standing under the Laws of the State of Delaware, (ii) has all necessary power and authority to own, operate or lease the properties and assets owned, operated or leased by such Subsidiary and to
carry on its business as it has been and is currently conducted by such Subsidiary and (iii) is duly licensed or qualified to do business and is in good standing in each jurisdiction in which the properties owned or leased by it or the operation of
its business makes such licensing or qualification necessary.



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3.3 Capital Stock of the Company



The authorized capital stock of the Company consists of 100,000,000 shares of Common Stock and 5,000,000 shares of preferred
stock of the Company (Preferred Stock) (of which Preferred Stock there are designated 40,000 shares of Series A Preferred Stock, 13,000 shares of Series B Preferred Stock, 17,000 shares of Series C Preferred Stock and 1,400,000
shares of Series D Preferred Stock). As of the Signing Date, (a) 14,864,799 shares of Common Stock are issued and outstanding, (b) 2,691,136 shares of Common Stock are reserved for issuance pursuant to outstanding options granted pursuant to the
Companys 1995 Stock Plan, 1995 Directors Option Plan, 1999 Stock Plan, and 2002 Stock Plan, (c) 1,252,625 shares of Common Stock are reserved for issuance upon the exercise of outstanding warrants in the amounts and at the exercise prices
disclosed on Section 3.3 of the Disclosure Schedule, and (d) 2,000 shares of Series C Preferred Stock are issued and outstanding, 1,385,377 shares of Series D Preferred Stock are issued and outstanding, and no other shares of Preferred Stock are
outstanding. Except as provided in Section 3.3 of the Disclosure Schedule, no shares of capital stock of the Company are held in its treasury. All of the outstanding shares of the Companys capital stock are duly and validly issued, fully paid
and nonassessable. None of the issued and outstanding shares of capital stock of the Company was issued in violation of any preemptive rights. Except as set forth in the first sentence of this Section or in Section 3.3 of the Disclosure Schedule,
there are no options, warrants, subscriptions, calls, convertible securities or other rights, agreements, arrangements or commitments relating to the capital stock of the Company or obligating the Company to issue or sell any shares of capital stock
of, or any other equity interest in, the Company. There are no outstanding contractual obligations of the Company to repurchase, redeem or otherwise acquire any shares of capital stock of the Company or make any investment (in the form of a loan,
capital contribution or otherwise) in, any other Person. The shares of Common Stock to be issued and sold pursuant to this Agreement have been duly and validly authorized by the Company, and, upon the issuance of such shares to the Investor under
the terms of Section 2.1(c) herein and the Escrow Agreement, such shares of Common Stock will have been duly and validly issued, fully paid and non-assessable, and the issuance of such shares shall not be subject to preemptive or other similar
rights, except such rights of the Investor, which Investor has agreed to waive herein. There are no voting trusts, stockholder agreements, proxies or other agreements or understanding in effect with respect to the voting or transfer of any of the
Companys capital stock, except as described on Section 3.3 of the Disclosure Schedule. There are no accrued and unpaid dividends on any capital stock of the Company.



3.4 Authority and Qualification of the Company



(a) The Company has all necessary corporate power and authority to enter into the Transaction Documents, to carry out its
obligations thereunder and to consummate the transactions contemplated thereby, and the execution and delivery by the Company of the Transaction Documents, the performance by the Company of its obligations thereunder and the consummation by the
Company of the transactions contemplated thereby have been duly authorized by all requisite action on the part of the Company, except in each case for the shareholder approval contemplated by Section 2.1(c) herein for the sale and issuance of the
purchased shares to the Investor. Each Transaction Document has been, or upon its execution shall be, duly executed and delivered by the Company, and (assuming due execution and delivery thereof by each other party thereto, if applicable) each
Transaction Document



8



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constitutes, or upon its execution shall constitute, the legal, valid and binding obligation of the Company enforceable
against the Company in accordance with its terms, subject to (i) the effect of any applicable bankruptcy, insolvency, reorganization, moratorium and other similar Laws relating to or affecting creditors rights and remedies generally, and (ii)
the effect of general equitable principles, regardless of whether asserted in a proceeding in equity or at law.



(b) All corporate actions taken by the Company have been duly authorized, and the Company has not taken any action that in any respect conflicts with,
constitutes a default under or results in a violation of any provision of its restated certificate of incorporation or by-laws, excluding any such action that would not have a Material Adverse Effect.



3.5 No Conflict



Except as provided in Section 3.5 of the Disclosure Schedule, the execution,
delivery and performance by the Company of the Transaction Documents does not (a) violate, conflict with or result in the breach of any provision of its restated certificate of incorporation or by-laws, (b) conflict with or violate any Law or
Governmental Order applicable to the Company, or any of its assets, properties or businesses, or (c) conflict with, result in any breach of, constitute a default (or event which with the giving of notice or lapse of time, or both, would become a
default) under, require any consent under, or give to others any rights of termination, amendment, acceleration, suspension, revocation or cancellation of, or result in the creation of any Encumbrance on any of the properties as assets of the
Company pursuant to, any note, bond, mortgage or indenture, contract, agreement, lease, sublease, license, permit, franchise or other instrument or arrangement to which the Company is a party or by which any of assets or properties is bound or
affected, except, with respect to clause (c), for any such conflicts, violations, breaches, defaults or other occurrences that have not had, and would not be reasonably expected to have, individually or in the aggregate, a Material Adverse Effect.



3.6 Governmental Consents and Approvals



The execution, delivery and performance of the Transaction Documents by the
Company does not require any consent, approval, authorization or other order of, action by, filing with or notification to, any Governmental Authority other than (a) any approval of, filing with or notification to NASDAQ, and (b) such registrations,
filings and authorizations as may be required under federal and state securities laws.



3.7 Absence of Certain Changes or Events; Conduct in Ordinary Course



Except as set forth in Section 3.7 of the Disclosure Schedule, since the Reference Statement Date, the business of the Company has been conducted in the
ordinary course, in a manner consistent with past practices and there has been no Material Adverse Effect.



3.8 SEC Filings; Financial Statements



(a) The Company has filed all forms, reports and documents required to be filed by it with the Securities and Exchange Commission (the
SEC). The Company heretofore has filed with the SEC, (i) its Annual Report on Form 10-K for the fiscal year ended December 31, 2004, (ii) its Quarterly Report on Form 10-Q for the quarterly period ended



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March 31, 2005, (iii) all proxy statements relating to the Companys meetings of stockholders (whether annual or
special) held since January 1, 2005 and (iv) all other forms, reports and other registration statements (other than Quarterly Reports on Form 10-Q not referred to in clause (ii) above) filed by the Company with the SEC since January 1, 2005 (the
forms, reports and other documents referred to in clauses (i), (ii), (iii) and (iv) above being, collectively, the Company SEC Reports). As of their respective filings dates, the Company SEC Reports (x) were prepared in accordance
with either the requirements of the Securities Act of 1933, as amended (the Securities Act), or the Securities Exchange Act of 1934, as amended (the Exchange Act), as the case may be, and the rules and
regulations promulgated thereunder, and (y) did not, at the time they were filed, or, if amended, as of the date of such amendment, contain any untrue statement of a material fact or omit to state a material fact required to be stated therein or
necessary in order to make the statements made therein, in the light of the circumstances under which they were made, not misleading. No Subsidiary of the Company is required to file any form, report or other document with the SEC.



(b) Each of the consolidated financial statements (including, in each case,
any notes thereto) contained in the Company SEC Reports (the Company Financial Statements) was prepared in accordance with U.S. GAAP applied on a consistent basis throughout the periods indicated (except as may be indicated in the
notes thereto or, in the case of unaudited statements, as permitted by Form 10-Q of the SEC) and each fairly presents, in all material respects, the consolidated financial position, results of operations and cash flows of the Company and its
consolidated Subsidiaries as at the respective dates thereof and for the respective periods indicated therein (subject, in the case of unaudited statements, to normal and recurring year-end adjustments which would not have had, and would not have, a
Material Adverse Effect). The Company maintains systems of internal accounting controls that are, in all material respects, typical for companies of its size and in its industry and sufficient to provide reasonable assurance that (i) transactions
are executed in accordance with managements general or specific authorizations, (ii) transactions are recorded as necessary to permit preparation of financial statements in conformity with U.S. GAAP and to maintain asset accountability, (iii)
access to its assets is permitted only in accordance with managements general or specific authorization and (iv) the recorded accountability for its assets is compared with its existing assets at reasonable intervals and appropriate action is
taken with respect to any differences. Except as specifically disclosed in the notes to the Company Financial Statements, there are no material special or non-recurring items of income or expense during the periods covered by the Company Financial
Statements and the balance sheets included in the Company Financial Statements do not reflect any writeup or revaluation increasing the book value of any assets.



(c) Except as and to the extent set forth on the consolidated balance sheet of the Company and the consolidated Subsidiaries
as of March 31, 2005, including the notes thereto (the Reference Statement Date) or in Section 3.8(c) of the Disclosure Schedule, neither the Company nor any Subsidiary has any liability or obligation of any nature (whether
accrued, absolute, contingent or otherwise), except for liabilities and obligations incurred in the ordinary course of business consistent with past practice which have not had and would not reasonably be expected to have a Material Adverse Effect.



(d) As of the date of this Agreement, the Company has
heretofore furnished to the Investor complete and correct copies of (i) all agreements, documents and other instruments



10



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not yet filed by the Company with the SEC but that are currently in effect and that the Company expects to file with the
SEC after the date of this Agreement and (ii) all amendments and modifications that have not been filed by the Company with the SEC to all agreements, documents and other instruments that previously had been filed by the Company with the SEC and are
currently in effect.



3.9 Litigation



Except as set forth on Section 3.9 of the Disclosure Schedule, there is no
Action pending (or, to the knowledge of the Company, threatened) by or against the Company or either of its two Subsidiaries. Neither the Company nor either of its two Subsidiaries is subject to any Governmental Order (nor, to the knowledge of the
Company, are there any Governmental Orders threatened to be imposed by any Governmental Authority) which has resulted or would reasonably be expected to have a Material Adverse Effect.



3.10 Compliance with Laws



Except as would not reasonably be expected to have a Material Adverse Effect, (a) the Company and its Subsidiaries have conducted and continue to
conduct their business in all respects in accordance with all Laws and Governmental Orders applicable to the Company and such Subsidiaries, and (b) neither the Company nor any Subsidiary is in violation of any such Law or Governmental Order.



3.11 Assets



Except as disclosed in Section 3.11 of the Disclosure Schedule, the Company
(directly or through its subsidiary VGI) owns, lease or has the legal right to use all the properties and assets used or intended to be used in the conduct of the business of the Company or otherwise owned, leased or used by the Company
(collectively, the Assets).



3.12 Brokers



No broker, finder or investment banker is entitled to any
brokerage, finders or other fee or commission in connection with the transactions contemplated by the Transaction Documents based upon arrangements made by or on behalf of the Company.



3.13 Employment and Benefits Matters



None of the Plans is subject to Title IV of ERISA or Section 412 of the
Code, nor does the Company or any Subsidiary contribute to any multiemployer plan as defined in Section 3(37) of ERISA. The Company has performed all material obligations required to be performed by it under, is not in any material
respect in default under or in material violation of, and has no knowledge of any material default or violation by any party to, any Plan.



3.14 Insurance



All material insurable risks of the Company and its Subsidiaries in respect of the businesses of each are covered by insurance policies, and the types and
amounts of coverage



11



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provided therein are usual and customary when compared to those of other companies of substantially similar size in the
context of the businesses and operations in which the Company and the Subsidiaries are engaged.



3.15 Regulatory Compliance



Each product or drug related to VEGF-2 that is tested or created by the Company is being tested or created in compliance with all material requirements of
applicable Law. As of the date of this Agreement, the Company is not testing anything other than VEGF-2 or products or drugs related thereto. Since July 30, 2003, the Company has not received any notice from the FDA or any other Governmental
Authority alleging any violation by the Company of any Law relating to VEGF-2. Except as disclosed in Section 3.15 of the Disclosure Schedule, the Company has not received any written notice that the FDA or any other Governmental Authority has
threatened to investigate or suspend any research activities, pre-clinical programs or clinical trials being conducted by the Company relating to VEGF-2.



3.16 Absence of Undisclosed Liabilities



There are no liabilities of the Company or either of its Subsidiaries of any nature (whether absolute, accrued, contingent or otherwise) other than (a)
those liabilities reflected or reserved against on the March 31, 2005 balance sheet that is set forth in the Company SEC Reports, including the notes thereto, (b) those liabilities set forth in Section 3.16 of the Disclosure Schedule and (c)
liabilities which would not reasonably be expected to have a Material Adverse Effect.



3.17 Full Disclosure



No representation or warranty of the Company in this Agreement, nor any statement or certificate furnished or to be furnished by the Company to the Investor pursuant to this Agreement, or in connection with the transactions contemplated
thereby, contains any untrue statement of a material fact, or omits to state a material fact necessary to make the statements contained herein or therein not misleading. The Company is not aware of any facts pertaining to the Company, its
Subsidiaries or their business which would reasonably be expected to materially affect adversely any of them and which have not been disclosed in this Agreement, the Disclosure Schedule or the Company Financial Statements or otherwise disclosed to
the Investor by the Company in writing.



3.18 Clinical
Trials; Product Data



Except as set forth in Section 3.18
of the Disclosure Schedule, the clinical, pre-clinical, safety and other studies and tests conducted by or on behalf of or sponsored by the Company or its agents or in which the Companys product candidates under development have participated,
were and, if still pending, are, to the Companys knowledge, being conducted in accordance with medical and scientific research procedures. The Company and, to the Companys knowledge, its agents have operated within, and currently are in
compliance with, all applicable rules, regulations and policies of the FDA and other applicable foreign authorities. Except as set forth in Section 3.18 of the Disclosure Schedule, neither the Company nor, to the Companys knowledge, its agents
have received any notices or other correspondence from the FDA, other foreign authority, or any other governmental entity requiring the termination, suspension, or modification of any clinical, pre-clinical, safety or other studies or tests.



12



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3.19 NASDAQ



The Company represents that it is in compliance with all the applicable requirements of the rules and regulations of the
NASDAQ Stock Market (NASDAQ).



ARTICLE 4



REPRESENTATIONS AND WARRANTIES

OF THE INVESTOR



The Investor hereby represents and warrants to the Company as follows:



4.1 Organization and Authority of the Investor



The Investor is a corporation duly organized, validly existing and in good standing under the Laws of the State of Delaware
and has all necessary corporate power and authority to enter into the Transaction Documents, to carry out its obligations thereunder and to consummate the transactions contemplated thereby. The execution and delivery by the Investor of the
Transaction Documents, the performance by the Investor of its obligations thereunder and the consummation by the Investor of the transactions contemplated thereby have been duly authorized by all requisite corporate action on the part of the
Investor. Each Transaction Document has been, or upon its execution shall be, duly executed and delivered by the Investor, and (assuming due execution and delivery thereof by each other party thereto, if applicable) each Transaction Document
constitutes, or upon its execution, shall constitute, the legal, valid and binding obligations of the Investor, enforceable against the Investor in accordance with its terms, subject to (a) the effect of any applicable bankruptcy, insolvency,
reorganization, moratorium, and other similar Laws relating to or affecting creditors rights and remedies generally, and (b) the effect of general equitable principles, regardless of whether asserted in a proceeding in equity or at law.



4.2 No Conflict



The execution, delivery and performance by the Investor of the Transaction
Documents do not (a) violate, conflict with or result in the breach of any provision of the certificate of incorporation or the by-laws of the Investor, (b) conflict with or violate any Law or Governmental Order applicable to the Investor or any of
its assets, properties or businesses or (c) conflict with, or result in any breach of, constitute a default (or event which with the giving of notice or lapse of time, or both, would become a default) under, require any consent under, or give to
others any rights of termination, amendment, acceleration, suspension, revocation or cancellation of, any note, bond, mortgage or indenture, contract, agreement, lease, sublease, license, permit, franchise or other instrument or arrangement to which
the Investor is a party, which, in the case of this clause (c), would adversely affect the ability of the Investor to carry out its obligations under, and to consummate the transactions contemplated by, the Transaction Documents.



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4.3 Governmental Consents and Approvals



The execution, delivery and performance by the Investor of the Transaction
Documents does not require any consent, approval, authorization or other order of, action by, filing with, or notification to any Governmental Authority.



4.4 Brokers



No broker, finder or investment banker is entitled to any brokerage, finders or other fee or commission in connection with the transactions
contemplated by the Transaction Documents based upon arrangements made by or on behalf of the Investor.



4.5 Accredited Investor and Investment Experience



The Investor is an accredited investor within the meaning of Rule 501 of Regulation D promulgated under the Securities Act. In addition, the
Investor is knowledgeable, sophisticated and experienced in making, and is qualified to make, decisions with respect to investments in securities representing an investment decision like that involved in the purchase of the shares purchased
hereunder.



4.6 Investment Intent



The Investor is acquiring the shares of Common Stock of the Company for its
own account solely for the purpose of investment and not as a nominee or agent and not with a view to, or for offer or sale in connection with, any distribution thereof. The Investor shall not, directly or indirectly, offer, sell, pledge, transfer
or otherwise dispose of (or solicit any offers to buy, purchase or otherwise acquire or take a pledge of) any of the shares purchased hereunder except in accordance with the Securities Act and applicable state securities laws.



4.7 Information and Risk.



(a) The Investor has requested, received, reviewed and considered all
information the Investor deems relevant in making an informed decision to purchase the shares. The Investor has had an opportunity to discuss the Companys business, management and financial affairs with its management and also had an
opportunity to ask questions of officers of the Company that were answered to such the Investors satisfaction, provided that such inquiries do not impair the rights of the Investor to rely on the representations and warranties of the Company
as set forth in Article 3 herein.



(b) The Investor recognizes
that an investment in the shares involves a high degree of risk, including a risk of total loss of the Investors investment. The Investor is able to bear the economic risk of holding the shares for an indefinite period or complete loss of the
investment, and has knowledge and experience in the financial and business matters such that it is capable of evaluating the risks of the investment in the shares.



14



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4.8 Legends



The Investor understands that, until such time as the shares of Common Stock issued to the Investor hereunder may be sold
under an effective registration statement under the Securities Act, or an exemption under the Securities Act and applicable state securities Laws, such shares of Common Stock will bear a restrictive legend in substantially the following form (and a
stop-transfer order may be placed against transfer of the certificates for such securities):



The securities represented by this certificate have not been registered under the Securities Act of 1933, as amended (the Securities Act), or under the securities Laws of any other
jurisdiction. These securities have been acquired for investment and not with a view to, or in connection with, the distribution thereof. The securities may not be offered, sold, pledged, transferred or assigned in the absence of an effective
registration statement for the securities under the Securities Act and applicable state securities Laws, unless sold pursuant to an exemption under the Securities Act and applicable state securities Laws.



ARTICLE 5



COVENANTS AND AGREEMENTS



5.1 Conduct of Business



As and from the date hereof until the earlier of the Closing Date and the date that this Agreement is terminated in accordance with its terms, the Company
shall refrain from taking any action that would be inconsistent with the Registration Rights Agreement were such agreement in effect on the date hereof.



5.2 Governmental Proceedings



Each of the Parties shall promptly advise the other of the existence of the commencement of any Action or the existence of any Governmental Order, in each
case of which such Party is or becomes aware, which Action would reasonably be expected to affect the legality, validity or enforceability of this Agreement or any other Transaction Document or the consummation of any of the transactions
contemplated by this Agreement or thereby.



5.3 Listing



The Company shall use its reasonable best efforts to
obtain approval for the listing on the NASDAQ (or such other national securities exchange as the Common Stock may be listed) of the shares of Common Stock purchased by the Investor, and the Company shall cooperate with the Investor with respect to
such listing.



5.4 Waiver of Antidilution Rights



Investor hereby waives any anti-dilution rights Investor
may have with respect to the sale, purchase and issuance of the shares of Common Stock purchased hereunder, including any Conversion Price adjustment with respect to the sale, purchase and issuance of such shares under



15



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Section B(5)(d) of the Companys Certificate of Designation of Preferences and Rights of Series D Preferred Stock.
In furtherance thereof, Investor shall appear, in person or by proxy, at the Companys Special Meeting of Stockholders for the purpose of approving the transactions contemplated by this Agreement, as will be described in a definitive proxy
statement filed by the Company with the SEC, and at every adjournment or postponement thereof, or otherwise cause its shares of the Companys voting stock to be counted as present at such meeting for purposes of establishing a quorum and will
vote its shares in favor of both (a) the sale and issuance by the Company to Investor of the shares purchased hereunder and the other transactions contemplated hereby and (b) an amendment to the Companys Certificate of Designation of
Preferences and Rights of Series D Preferred Stock in substantially the form of Exhibit F attached hereto.



ARTICLE 6



USE OF PROCEEDS



6.1 Research and
Development



Upon release of the Escrowed Funds to the
Company pursuant to the terms of Section 2.1(c) herein and the Escrow Agreement, the Company shall apply the $8,000,003.20to be paid for the subscription of the shares of Common Stock toward the performance of its obligations under the Development Agreement dated as of July 30, 2003
between the Parties, as amended, and the Distribution Agreement and for general corporate purposes, including costs incurred in the manufacturing and processing of the Companys drug products.



ARTICLE 7



CONDITIONS PRECEDENT



7.1 Conditions to the Investors Obligations



The obligations of the Investor to consummate the transactions contemplated by Article 2 are subject to the satisfaction, or waiver by the Investor, on
the Closing Date, of each of the following conditions:



(a)
Representations and Warranties; Covenants and Agreements. The representations and warranties of the Company contained in this Agreement shall have been true and correct in all material respects when made and shall be true and correct in all
material respects as of the Closing with the same force and effect as if made as of the Closing, other than such representations and warranties as are made as of another date, which shall be true and correct in all material respects as of such date
(provided, however, that if any portion of any representation or warranty is already qualified by materiality, for purposes of determining whether this Section 7.1(a) has been satisfied with respect to such portion of such representation or
warranty, such portion of such representation or warranty as so qualified must be true and correct in all respects), and the covenants and agreements contained in this Agreement to be complied with by the Company on or before the Closing shall have
been complied with in all material respects, and the Investor shall have received a certificate of the Company to such effect signed by a duly authorized officer thereof;



16



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(b) No Proceedings. No Governmental Order shall be in effect, and no Action shall be pending, in
each case against the Company or the Investor, seeking to restrain the consummation of the transactions contemplated by the Transaction Documents;



(c) No Insolvency Event. Neither the Company nor either of its Subsidiaries has made a general assignment for the benefit of creditors, nor has any
proceeding been instituted by or against the Company, the Company or any Subsidiary seeking to adjudicate any of them a bankrupt or insolvent, or seeking liquidation, winding up or reorganization, arrangement, adjustment, protection, relief or
composition of its debts under any Law relating to bankruptcy, insolvency or reorganization; and



(d) Consents. The Company shall have received all consents referred to in Section 3.6; provided, however, any consents required for the
Companys sale and issuance of the shares purchased hereunder, including NASDAQ approval, shall not be required at the Closing but shall be required prior to release of the Escrowed Funds to the Company as provided in Section 2.1(c) and the
Escrow Agreement.



7.2 Conditions to the Companys
Obligations



The obligations of the Company to consummate
the transactions contemplated by Article 2 are subject to the satisfaction, or waiver by the Company, on the Closing Date, of each of the following conditions:



(a) Representations and Warranties; Covenants and Agreements. The representations and warranties of the Investor contained in this Agreement
shall have been true and correct in all material respects when made and shall be true and correct in all material respects as of the Closing, with the same force and effect as if made as of the Closing Date, other than such representations and
warranties as are made as of another date, which shall be true and correct in all material respects as of such date (provided, however, that if any portion of any representation or warranty is already qualified by materiality, for purposes of
determining whether this Section 7.2(a) has been satisfied with respect to such portion of such representation or warranty, such portion of such representation or warranty as so qualified must be true and correct in all respects), and the covenants
and agreements contained in this Agreement to be complied with by the Investor on or before the Closing shall have been complied with in all material respects, and the Company shall have received a certificate from the Investor to such effect signed
by a duly authorized officer thereof; and



(b) No
Proceedings. No Governmental Order shall be in effect, and no Action shall be pending, in each case against the Company or the Investor, seeking to restrain the consummation of the transactions contemplated by the Transaction Documents.



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ARTICLE 8



INDEMNIFICATION



8.1 Survival of Representations, Warranties and Indemnities



(a) Unless this Agreement is earlier terminated pursuant to Article 9, the representations, warranties and indemnities of
the Company contained in this Agreement shall survive the Closing Date and remain in full force and effect until the second anniversary of the Closing Date; provided, however, that Sections 3.3 and 3.12 shall survive indefinitely. Neither the period
of survival nor the liability of the Company with respect to its representations, warranties and indemnities shall be reduced by any investigation made at any time by or on behalf of the Investor. If written notice of a claim has been given prior to
the expiration of the applicable representations, warranties and indemnities by the Investor to the Company, then the relevant representations, warranties and indemnities shall survive as to such claim, until such claim has been finally resolved.



(b) Unless this Agreement is earlier terminated pursuant to
Article 9, the representations, warranties and indemnities of the Investor contained in this Agreement shall survive the Closing Date and remain in full force and effect until the second anniversary thereof; provided, however, that Section 4.4 shall
survive indefinitely. Neither the period of survival nor the liability of the Investor with respect to the Investors representations, warranties and indemnities shall be reduced by any investigation made at any time by or on behalf of the
Company.



8.2 Indemnification by the Company



The Investor and its Affiliates, officers, directors, employees, agents,
successors and assigns (each, an Investor Indemnified Party) shall be indemnified and held harmless by the Company for and against any and all liabilities, losses, damages, claims, costs and expenses, interest, awards, judgments
and penalties (including, without limitation, reasonable attorneys and consultants fees and expenses) actually suffered or incurred by them (including, without limitation, any Action brought or otherwise initiated by any of them)
(hereinafter a Loss), arising out of or resulting from the breach of any representation or warranty, covenant or agreement made by the Company contained in this Agreement. To the extent that the undertakings of the Company set
forth in this Section 8.2 may be unenforceable, the Company shall contribute the maximum amount that it is permitted to contribute under applicable Law to the payment and satisfaction of all Losses incurred by the Investor Indemnified Parties.



8.3 Indemnification by the Investor



The Company and its Affiliates, officers, directors, employees, agents,
successors and assigns (each a Company Indemnified Party) shall be indemnified and held harmless by the Investor for and against any and all Losses arising out of or resulting from the breach of any representation or warranty,
covenant or agreement made by the Investor contained in this Agreement. To the extent that the Investors undertakings set forth in this Section 8.3 may be unenforceable, the Investor shall contribute the maximum amount that it is permitted to
contribute under applicable Law to the payment and satisfaction of all Losses incurred by the Company Indemnified Parties.



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8.4 Treatment for Tax Purposes



To the extent permitted by Law, the Parties agree, solely for Tax purposes, to treat all payments made under this Article 8,
under any other indemnity provision contained in this Agreement, and for any misrepresentations or breach of warranties or covenants, as adjustments to the consideration paid by the Investor under Article 2 for all Tax purposes, except to the extent
the Law of a particular jurisdiction provides otherwise.



8.5 Limitations on Indemnification



The
indemnification obligations of the Company and the Investor for breach of representation or warranty pursuant to Section 8.2 and Section 8.3, respectively, shall not be effective unless the aggregate dollar amount of all Losses that would otherwise
be indemnifiable pursuant thereto exceeds $1,000,000 (Threshold Amount), at which time the indemnification obligations shall be effective as to all Losses, including the Threshold Amount; provided, however, that the Threshold
Amount shall not apply to any Losses arising out of or relating to Section 3.3. The indemnification obligations of the Company and the Investor pursuant to Section 8.2 and 8.3, respectively, shall be effective only until the dollar amount paid in
respect of Losses under such Section aggregates to $8,000,003.20and no indemnification pursuant to such provisions shall be payable thereafter.



ARTICLE 9



TERMINATION



9.1 Termination



This Agreement may be terminated at any time prior to the Closing:



(a) by either the Company or the Investor if the Closing
(excluding the satisfaction of the conditions for the release of the Escrowed Funds by the Escrow Agent to the Company as provided in Section 2.1(c) of this Agreement) shall not have occurred by August 1, 2005; provided, however, that the right to
terminate this Agreement under this Section 9.1(a) shall not be available to any party whose failure to fulfill any obligation under this Agreement shall have been the cause of, or shall have resulted in, the failure of the Closing to occur on or
prior to such date;



(b) by either the Investor or the Company
in the event that any Governmental Authority shall have issued an order, decree or ruling or taken any other action restraining, enjoining or otherwise prohibiting the transactions contemplated by this Agreement and such order, decree, ruling or
other action shall have become final and nonappealable; or



(c)
by the mutual written consent of the Company and the Investor.



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9.2 Effect of Termination



In the event of termination of this Agreement as provided in Section 9.1, all further obligations of the Parties under this
Agreement shall terminate, except for those set forth in Articles 8, 9, 10 and 11 (other than Section 11.1) and that nothing herein shall relieve either party from liability for any breach of this Agreement.



ARTICLE 10



CONFIDENTIALITY



10.1 Confidentiality



The Receiving Party shall maintain Confidential Information in confidence,
and shall not disclose, divulge or otherwise communicate such Confidential Information to others, or use it for any purpose, except pursuant to, and in order to carry out, the terms and objectives of this Agreement. The Receiving Party hereby shall
exercise every reasonable precaution to prevent and restrain the unauthorized disclosure of such Confidential Information by any of its directors, officers, employees, consultants, subcontractors, or agents. Upon termination of this Agreement, or as
soon as practicable following the Closing, each Party hereby shall return to the other Party, upon demand, all Confidential Information in its possession or, upon demand, to destroy such Confidential Information and provide a certificate to the
other Party of such destruction signed by an officer of the destroying Party.



10.2 Release from Restrictions



The provisions of Section 10.1 shall not apply to any information disclosed hereunder that:



(a) is lawfully disclosed to the Receiving Party by an independent, unaffiliated third party rightfully in possession of the Confidential Information and
under no confidentiality or fiduciary obligation not to make disclosure;



(b) becomes published or generally known to the public through no fault or omission on the part of the Receiving Party;



(c) is developed independently by the Receiving Party without access to the Confidential Information of the Disclosing Party;



(d) is legally required to be disclosed to the FDA; provided, however, the
Receiving Party shall continue to treat such information as confidential pursuant to Section 10.1 unless and until such information becomes published or generally known to the public through no fault or omission on the part of the Receiving Party;
or



(e) a Party is legally compelled to disclose; provided,
however, that the Receiving Party shall provide prompt written notice of such requirement to the Disclosing Party so that the Disclosing Party may seek a protective order or other remedy or waive compliance with Section 10.1; and provided further
that if such protective order or other remedy is not



20



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obtained or the Disclosing Party waives compliance with Section 10.1, the Receiving Party shall be permitted to furnish
only that portion of such Confidential Information that is legally required to be provided and the Receiving Party shall exercise its reasonable best efforts to obtain assurances that confidential treatment shall be accorded such information.



10.3 Public Announcements and Publications



Except as required by Law or by the requirements of any securities
exchange on which the securities of a Party hereto are listed, no Party to this Agreement shall make, or cause to be made, any press release or public announcement in respect of this Agreement or the transactions contemplated hereby or otherwise
communicate with any news media in respect of this Agreement or the transactions contemplated hereby without the prior written consent of the other Party. The Parties shall cooperate as to the timing and contents of any such press release or public
announcement.



ARTICLE 11



GENERAL PROVISIONS



11.1 Further Action



Each of the Parties shall use commercially reasonable efforts to take, or
cause to be taken, all appropriate action, do or cause to be done all things necessary, proper or advisable under applicable Law, and to execute and deliver such documents and other papers, as may be required to carry out the provisions of this
Agreement and consummate and make effective the transactions contemplated hereby.



11.2 Expenses



Except
as otherwise specified in this Agreement, all costs and expenses, including, without limitation, fees and disbursements of counsel, financial advisors and accountants, incurred in connection with this Agreement and the transactions contemplated by
this Agreement shall be paid by the Party incurring such costs and expenses.



11.3 Notices



All
notices, requests, claims, demands and other communications hereunder shall be in writing and shall be given or made by delivery in person, by an internationally recognized overnight courier service, by telecopy or registered or certified mail
(postage prepaid, return receipt requested) to the respective Parties at the following addresses (or at such other address for a party as shall be specified in a notice given in accordance with this Section 11.3):



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| | (a) | if to the Company:
| | --- | ------------------



| |  | Corautus Genetics Inc.
| |  | ----------------------

| |  | 75 Fifth Street, NW
| |  | -------------------

| |  | Suite 313
| |  | ---------

| |  | Atlanta, GA 30318
| |  | -----------------

| |  | Telecopy: (404) 526-6218
| |  | ------------------------

| |  | Attention: Chief Executive Officer
| |  | ----------------------------------



| |  | with a copy to:
| |  | ---------------



| |  | McKenna Long & Aldridge LLP
| |  | ---------------------------

| |  | 303 Peachtree Street, Suite 5300
| |  | --------------------------------

| |  | Atlanta, GA 30308
| |  | -----------------

| |  | Telecopy: (404) 527-4198
| |  | ------------------------

| |  | Attention: Robert E. Tritt
| |  | --------------------------



| | (b) | if to the Investor:
| | --- | -------------------



| |  | Boston Scientific Corporation
| |  | -----------------------------

| |  | One Boston Scientific Place
| |  | ---------------------------

| |  | Natick, MA 01760-1537
| |  | ---------------------

| |  | Telecopy: (508) 650 8956
| |  | ------------------------

| |  | Attention: General Counsel
| |  | --------------------------



Any notice, if mailed and properly addressed with postage prepaid or if properly addressed and sent by pre-paid courier service, shall be deemed given
when received; any notice, if transmitted by facsimile, shall be deemed given when the confirmation of transmission thereof is received by the transmitter.



11.4 Interpretation and Rules of Construction



In this Agreement, except to the extent that the context otherwise requires:



(a) when a reference is made in this Agreement to an Article, Section, Exhibit or Schedule, such reference is to an Article
or Section of, or a Schedule to, this Agreement unless otherwise indicated;



(b) the table of contents and headings in this Agreement are for reference purposes only and do not affect in any way the meaning or interpretation of this Agreement;



(c) whenever the words include, includes or
including are used in this Agreement, they are deemed to be followed by the words without limitation;



(d) the words hereof, herein and hereunder and words of similar import, when used in this Agreement, refer to this
Agreement as a whole and not to any particular provision of this Agreement;



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(e) all terms defined in this Agreement have such defined meanings when used in any certificate or other
document made or delivered pursuant hereto, unless otherwise defined therein;



(f) the definitions contained in this Agreement are applicable to the singular as well as the plural forms of such terms;



(g) any Law defined or referred to herein or in any agreement or instrument that is referred to herein means such Law or statute as from time to time
amended, modified or supplemented, including by succession of comparable successor Laws;



(h) references to a Person are also to its permitted successors and assigns;



(i) the use of or is not intended to be exclusive unless expressly indicated otherwise; and



(j) all references to currency, monetary values and dollars shall mean United
States (U.S.) dollars and all payments hereunder shall be made in United States dollars.



11.5 Severability



If
any term or other provision of this Agreement is invalid, illegal or incapable of being enforced by any Law or public policy, all other terms and provisions of this Agreement shall nevertheless remain in full force and effect for so long as the
economic or legal substance of the transactions contemplated by this Agreement is not affected in any manner materially adverse to any party. Upon such determination that any term or other provision is invalid, illegal or incapable of being
enforced, the Parties shall negotiate in good faith to modify this Agreement so as to effect the original intent of the Parties as closely as possible in an acceptable manner in order that the transactions contemplated by this Agreement are
consummated as originally contemplated to the greatest extent possible.



11.6 Entire Agreement



The Transaction
Documents constitute the entire agreement of the Parties with respect to the subject matter thereof and supersede all prior agreements and undertakings, both written and oral, among the Parties with respect to the subject matter hereof and thereof.



11.7 Assignment



This Agreement shall be binding upon and inure to the benefit of the Parties
hereto and their respective successors and permitted assigns. Neither Party may assign this Agreement without the prior written consent of the other Party. No assignment by either Party permitted hereunder shall relieve the applicable Party of its
then-existing obligations under this Agreement.



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11.8 No Third Party Beneficiaries



This Agreement shall be binding upon and inure solely to the benefit of the Parties and their permitted assigns and nothing
herein, express or implied, is intended to or shall confer upon any other Person any legal or equitable right, benefit or remedy of any nature whatsoever.



11.9 Amendment



This Agreement may not be amended or modified except by an instrument in writing signed by authorized representatives of the Company and the Investor.



11.10 No Waiver



The delay or failure of either Party to enforce at any time for any period
the provisions of or any rights deriving from this Agreement shall not be construed to be a waiver of such provisions or rights or the right of such Party thereafter to enforce such provisions.



11.11 Dispute Resolution



Except to the limited extent necessary to (i) avoid expiration of a claim,
(ii) comply with deadlines under applicable Law, or (iii) obtain interim relief, including injunctive relief, to preserve the status quo or prevent irreparable harm, neither Party shall file an action or institute legal proceedings with respect to
any dispute, controversy, or claim arising out of this Agreement or the validity, interpretation, breach or termination thereof, including claims seeking redress or asserting rights under any Law, until:



(a) the aggrieved Party has given the other Party written notice
(Notice of Disagreement), in accordance with Section 11.3 of this Agreement, of its grievance setting forth the basis for such dispute and the remedy desired;



(b) the other Party has failed to provide a prompt and effective remedy (in the view of the aggrieved Party);



(c) the aggrieved Party has requested in writing senior executives for both
Parties to promptly meet and discuss the matter detailed in the Notice of Disagreement in order to consider informal and amicable means of resolution; and



(d) (i) the senior executives for both Parties have met at least three times and have not been able to resolve the dispute to the mutual satisfaction of
the Parties or (ii) more than sixty (60) Business Days have passed since the date of the Notice of Disagreement.



11.12 Governing Law



This Agreement shall be governed by, and construed in accordance with, the Laws of the State of New York. The Parties unconditionally and irrevocably
agree and consent to the exclusive jurisdiction of the federal and state courts located in the Borough of Manhattan, State of New York and waive any objection with respect thereto, for the purpose of any action, suit or proceeding arising out of or
relating to this Agreement or the transactions contemplated hereby, and further agree not to commence any such action, suit or proceeding except in any such court.



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11.13 Counterparts



This Agreement may be executed and delivered (including by facsimile transmission) in one or more counterparts, and by the
different Parties in separate counterparts, each of which when executed shall be deemed to be an original, but all of which taken together shall constitute one and the same agreement. Delivery of an executed counterpart of a signature page to this
Agreement by facsimile shall be effective as delivery of a manually executed counterpart of this Agreement.



11.14 Waiver of Jury Trial



Each of the Company and the Investor hereby knowingly, voluntarily and irrevocably waives all right to trial by jury in any action, proceeding or
counterclaim (whether based on contract, tort or otherwise) arising out of or relating to this Agreement or any course of conduct, course of dealing or statements (whether oral or written) or actions of the Company or the Investor in the
negotiation, administration, performance or enforcement thereof.



11.15 Construction; Interpretation



The
Parties have participated jointly in the negotiation and drafting of this Agreement. In the event an ambiguity or question of intent or interpretation arises, this Agreement shall be construed as if drafted jointly by the Parties and no presumption
or burden of proof shall arise favoring or disfavoring any Party by virtue of the authorship of any of the provisions of this Agreement.



11.16 Specific Performance



The Parties hereto agree that irreparable damage would occur in the event any provision of this Agreement was not performed in accordance with the terms
hereof and that the Parties shall be entitled to specific performance of the terms hereof, in addition to any other remedy at law or equity.



[Signature Page Follows]



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IN WITNESS WHEREOF, each of the Parties has caused this Agreement to be executed as of the date first
written above.



CORAUTUS GENETICS INC.By:

/s/ Richard E. OttoName:

Richard E. OttoTitle:

Chief Executive OfficerBOSTON SCIENTIFIC CORPORATIONBy:

/s/ Lawrence C. BestName:

Lawrence C. BestTitle:

Executive Vice President &Chief Financial Officer




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Exhibit A



Form of Registration Rights Agreement



Exhibit B



Form of Amendment to Loan Agreement



Exhibit C



Form of
Amendment to Distribution Agreement



Exhibit D



Form of Escrow Agreement



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Exhibit E



Form of Instructions to Transfer Agent



,
200











Dear ,



Please accept this letter as authorization to issue one
certificate to Boston Scientific Corporation for  shares of common stock, par value $0.001 per share, of Corautus Genetics Inc. (Corautus), and so record such
issuance on the stock register. The certificate shall be dated , 200. In addition, please affix the following legend on the certificate:



THE SECURITIES REPRESENTED BY THIS CERTIFICATE HAVE NOT BEEN
REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED (THE SECURITIES ACT), OR UNDER THE SECURITIES LAWS OF ANY OTHER JURISDICTION. THESE SECURITIES HAVE BEEN ACQUIRED FOR INVESTMENT AND NOT WITH A VIEW TO, OR IN CONNECTION WITH, THE
DISTRIBUTION THEREOF. THE SECURITIES MAY NOT BE OFFERED, SOLD, PLEDGED, TRANSFERRED OR ASSIGNED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT FOR THE SECURITIES UNDER THE SECURITIES ACT AND APPLICABLE STATE SECURITIES LAWS, UNLESS SOLD
PURSUANT TO AN EXEMPTION UNDER THE SECURITIES ACT AND APPLICABLE STATE SECURITIES LAWS.



Finally, please deliver the new certificate to the stockholders address of record, which is as follows:



Craig Smith, Esq.

One Prime Park Way

Natick, MA 01760-1537



Thank you for your attention in this matter. Should you have any questions, please do not hesitate to contact me.



Sincerely,Jack CallicuttVice President- Finance and Administration




|cc: | Richard E. Otto, Chief Executive Officer
|--- | ----------------------------------------



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Exhibit F



Form of Amendment to Series D Certificate of Designation



Exhibit G



Form of Legal Opinion