Treatment Time Animal ID Body Wt.(g) Uterus Wt (g) pit wt (mg) Cycle LH (ng/ml) Progesterone

1 Control 1200 33381 290.4 0.3673 10 ydp 0.39 10.3022 Control 1200 33025 318.4 0.4148 14.5 yd 0.175 11.1023 Control 1200 32647 281 0.2772 12.2 yd 0.295 5.7714 Control 1200 32678 246 0.3484 12.1 ydp 0.428 6.3515 Control 1200 32649 278 0.4914 17 E 0.53 2.2276 Control 1400 33430 269 0.3264 13.5 yd 0.531 15.3347 Control 1400 33413 292.6 0.3553 14 ydp 0.345 1.8658 Control 1400 33471 258.9 0.3517 10.6 ydp 0.206 21.1139 Control 1400 32655 280 0.4736 14.2 P 2.688 11.5

10 Control 1400 32659 241 0.4805 12.4 pE 0.502 2.4911 Control 1400 32254 280 0.4482 12.5 Pro 0.596 2.91612 Control 1400 32228 290 0.4001 14.3 Pe 0.55 ? 3.61613 Control 1400 32703 281 0.541 14.8 ydp 0.37 3.78714 Control 1400 32778 265 0.548 9 ydp 0.437 ? 1.63415 Control 1400 32826 281 0.3954 14.6 ydp 0.395 7.24816 Control 1400 32803 289 0.3463 10.8 ydp 0.207 2.54617 Control 1600 33431 308 1.0801 16.3 P 0.789 5.55618 Control 1600 33079 272.2 0.702 13.9 P 0.885 4.93319 Control 1600 33063 272.8 0.5319 13.3 P 0.556 5.79320 Control 1600 32280 339 0.8319 14 Pe 22.756 ? 12.86321 Control 1600 32268 283 0.464 13.1 ydP 0.823 59.8922 Control 1600 32675 248 0.2779 12.2 r2yd 0.254 84.3523 Control 1600 32638 236 0.3529 13.9 PE 0.828 128.8124 Control 1800 32701 239 0.7754 13.3 P 0.929 7.50325 Control 1800 33085 282.9 0.429 12.3 P 55.182out 60.907 out26 Control 1800 32662 271 0.4568 12.6 yd 0.516 43.4927 Control 2000 32635 269 0.6599 14.6 Pearly 0.491 2.1428 Control 2000 32679 255 0.3309 13.6 met 0.218 44.54 ?30 Control 2000 32862 328 0.4876 13.5 yd 0.381 51.03

1 6.25 mg/kg 1200 33521 307 0.3437 13.2 ydp 0.393 12.946 wild" rat-no sample

2 6.25 mg/kg 1200 33382 246.8 0.4079 10 yd 0.71 1.7593 6.25 mg/kg 1200 33026 273.3 0.3643 11.5 yd 0.553 3.324 6.25 mg/kg 1200 33022 250.6 0.4069 13.5 met 0.24 6.1185 6.25 mg/kg 1200 33421 297 0.3549 12.8 yd 0.39 19.152

Summary of data for rats not achieving one or more of the criteria set for vaginal proestrus.
6 6.25 mg/kg 1400 33149 278.6 0.4489 12.7 yd 0.211 5.523

7 6.25 mg/kg 1400 33473 319.6 0.4536 16.4 P 0.209 8.7228 6.25 mg/kg 1400 33489 285 0.3487 4 P 656.356out 15.433

9 6.25 mg/kg 1600 33087 280.8 0.493 15.9 P 0.401 3.161

10 6.25 mg/kg 1800 33526 330 0.3744 15.7 ydp 0.415 3.00111 6.25 mg/kg 1800 33480 269 0.4021 10.5 ydp 0.433 8.43212 6.25 mg/kg 2000 33151 297.5 0.4195 16 yd 0.314 33.386

1 12.5 mg/kg 1200 33033 255.7 0.4305 10.8 ydp 0.884 13.1012 12.5 mg/kg 1400 33045 278 0.4495 12.8 yd 0.332 2.4053 12.5 mg/kg 1400 33165 295.5 0.337 14.7 yd 0.478 20.17 no pit + ut=Pro-shorter4 12.5 mg/kg 1400 33506 324 0.4648 15 ydp 0.411 7.253 ut = Pro -shorter5 12.5 mg/kg 1400 33486 295.6 0.3598 15.5 ydp 1.360? 9.0796 12.5 mg/kg 1800 33137 290.8 0.4833 13.5 yd 0.398 5.7147 12.5 mg/kg 1800 33379 304 0.3831 12.6 yd 0.443 13.0211 25 mg/kg 1200 32698 265 0.2994 13.1 yd 0.227 4.6952 25 mg/kg 1200 32886 273 0.4968 12.5 yd 0.919 1.5923 25 mg/kg 1200 32814 259 0.3327 9.3 ydp 0.325 1.3934 25 mg/kg 1200 32650 277 0.4324 14.4 yd 0.832 5.2875 25 mg/kg 1200 32897 297 0.3512 14 E 0.233 3.8785 25 mg/kg 1400 32230 276 0.4446 11.4 ydp 0.64 2.6626 25 mg/kg 1400 32819 307 0.3379 12.9 yd 0.522 4.677 25 mg/kg 1400 32688 277 0.4522 14.2 P 1.051 74.458 25 mg/kg 1400 32666 290 0.4349 14.6 E 1 3.3469 25 mg/kg 1400 33449 313 0.4999 13.1 P 0.678 7.093

10 25 mg/kg 1400 33508 274 0.3665 12.1 ydp 0.365 4.611 25 mg/kg 1400 33397 296 0.3611 13.2 P 0.623 19.1212 25 mg/kg 1600 32215 271 0.4211 10.1 ydP 10.391 14.4613 25 mg/kg 1600 32185 263 0.4349 10.3 ydP 0.529 6.75114 25 mg/kg 1600 32705 268 0.3235 11.3 yd 1.654 21.5315 25 mg/kg 1600 32234 350 0.3291 14.6 ydp 0.649 5.71716 25 mg/kg 1800 33490 266 0.3264 12.5 ydp 0.537 6.07817 25 mg/kg 1800 33080 289.5 0.4521 14.1 P 0.262 8.66218 25 mg/kg 1800 33442 300 0.3727 15.9 ydp 0.374 7.13119 25 mg/kg 1800 32788 274 0.3753 14 yd 0.532 53.5920 25 mg/kg 1800 32249 267 0.4102 11.8 ydP 2.323 119.0121 25 mg/kg 1800 32813 302 0.489 15.1 yd 0.723 38.4622 25 mg/kg 1800 32669 288 0.3516 13.8 yd 0.461 51.9123 25mg/kg 1800 32637 247 0.3622 14.9 E 0.542 44.4424 25 mg/kg 1800 32711 295 0.3762 13.3 E out low 54.82 sample aspirated25 25 mg/kg 2000 33410 253 0.8238 15.4 P 90.426?ou 33.139

26 25 mg/kg 2000 33157 264.3 0.3449 11.8 yd 0.869 13.83427 25 mg/kg 2000 32615 291 0.363 11.7 ydp 0.327 8.24228 25 mg/kg 2000 32213 287 0.4823 12.4 ydstp 0.701 7.4529 25 mg/kg 2000 32651 314 0.4031 15.2 RE 0.402 2.44830 25 mg/kg 2000 32890 252 0.4725 13.5 E 0.447 4.582
21 25 mg/kg 2000 32696 263 0.4098 13.1 E 0.273 6.662

1 75 mg/kg 1200 32808 261 0.3996 12.2 ydp 0.197 4.272 75 mg/kg 1200 32700 275 0.4482 15.7 yd 0.469 2.6793 75 mg/kg 1200 32654 287 0.3742 12.2 ydP 0.341 5.2874 75 mg/kg 1400 32845 305 0.4757 13 ydp 0.822 3.6645 75 mg/kg 1400 32667 299 0.3965 12.2 ydP 0.358 4.5446 75 mg/kg 1400 32730 279 0.4636 10.5 yd 0.535 5.677 75 mg/kg 1600 32247 277 0.3581 14.5 ydp 0.515 9.7718 75 mg/kg 1600 32238 319 0.4252 13.1 yd 0.836 28.559 75 mg/kg 1600 32706 274 0.4096 13.7 stp? 0.88 10.664

10 75 mg/kg 1800 32833 266 0.4556 11.4 ydp 0.478 36.9811 75 mg/kg 1800 32729 271 0.405 13.7 E 0.227 1.83912 75 mg/kg 1800 32646 242 0.306 13.7 yd 0.468 17.1512 75 mg/kg 2000 32626 271 0.4646 11.5 ydp 0.47 6.57113 75 mg/kg 2000 32652 283 0.3408 16.9 pE 0.206 4.2915 75 mg/kg 2000 32208 305 0.3648 15.4 stp 0.298 7.5295