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Exhibit 10.46
 ***Text Omitted and Filed Separately
Confidential Treatment Requested
Under 17 C.F.R. §§ 200.80(b)(4) and 240.24b-2
 FIRST AMENDMENT
TO
LICENSE AGREEMENT
DATED AS OF SEPTEMBER 14, 1999
 by and between
 THE UNIVERSITY OF SOUTHERN CALIFORNIA
 And
 BIO-MANAGEMENT, INC. (NOW KNOWN AS CELL-MATRIX, INC.)
 Amendment Amendment Date Licensee License Agreement Party Parties
  1. Definitions
  2. Amendments
 2.1




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2.2
  2.3
  2.4
  2.5
 3. Exclusion of Patents
  4. Miscellaneous
 4.1
 4.2
 4.3




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Cell-Matrix, Inc.
    
    University of Southern California/s/ Jens Hennecke
    
    /s/ Dennis F. DoughertyName: Jens Hennecke
    
    Name: Dennis F. DoughertyTitle: VP of Business Development
    
    Title: Senior Vice President, Finance and CFODate: 3-2-2007
    
    Date: 3-2-2007




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Schedule 1
 Appendix A
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Schedule 2
 List of applications and patents of the University of Southern California related to [ ]
 Micrometref no.
    
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