----

| Execution      Copy |  |
|---------------------|--|

| 1.                      | Definitions      and Interpretation                                                        | 3      |
|-------------------------|--------------------------------------------------------------------------------------------|--------|
| 2.                      | Provision      of the Works and Services                                                   | 9      |
| 3.                      | Micromet's      Obligations                                                                | 12     |
| 4.                      | Governance                                                                                 | 13     |
| 5.                      | Inspections;      Person in Plant                                                          | 14     |
| 6.                      | Delivery,      Transportation of Product and Testing                                       | 15     |
| 7.                      | Price      and Terms of Payment                                                            | 17     |
| 8.                      | Intellectual      Property                                                                 | 17     |
| 9.                      | Warranties      and Indemnification                                                        | 19     |
| 10.                     | Confidentiality                                                                            | 22     |
| 11.                     | Option      for [***]                                                                      | 24     |
| 12.                     | Termination      of the Agreement, Termination of Certain Works and Services or      Slots | 24     |
| 13.                     | [***]                                                                                      | 27     |
| 14.                     | Technology      Transfer and License                                                       | 27     |
| 15.                     | Force      Majeure                                                                         | 27     |
| 16.                     | Governing      Law, Jurisdiction and Enforceability                                        | 28     |
| 17.                     | Notices                                                                                    | 29     |
| 18.                     | Illegality                                                                                 | 30     |
| 19.                     | Quality      Agreement                                                                     | 30     |
| 20.                     | Miscellaneous                                                                              | 30     |
|                    |                                                                                       |   |
| List      of Schedules: | 31                                                                                         |

----

| Execution      Copy |  |
|---------------------|--|

| 1. | LONZA      SALES AG, of Muenchensteinerstrasse 38, CH-4002 Basel, Switzerland (herein      after referred to as "Lonza")    and |
|----|---------------------------------------------------------------------------------------------------------------------------------|

| 2. | MICROMET      AG, of Staffelseestrasse 2, D-81477 Munich, Germany (herein after referred      to as "Micromet"). |
|----|------------------------------------------------------------------------------------------------------------------|

| A. | Micromet      is the proprietor of the single-chain bispecific anti-CD19 antibody (CD19      BiTE®)      known as Blinatumomab or MT103 and controls a manufacturing process and a      cell line for manufacture of MT103;and |
|----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| B. | Lonza      has the expertise in the evaluation and production of monoclonal      antibodies for therapeutic use using different processes and cell lines in      accordance with international regulatory requirements;  and |
|----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| C. | Micromet      and Lonza have previously entered into a Services Agreement dated      September 28, 2009 regarding the performance of a [***] to [***] for the      manufacturing of Micromet’s MT103 by Lonza;and |
|----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| D. | Micromet      wishes to contract Lonza for services relating to the development of the      Process (as defined herein) including all documentation, in each case,      suitable to obtain regulatory approval for commercialization of MT103 as a      therapeutic product and the manufacture of MT103 as described in this      Agreement, and |
|----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| E. | Lonza      is prepared to perform such services for Micromet on the terms and      conditions set out herein. |
|----|---------------------------------------------------------------------------------------------------------------|

| 1. | Definitions      and Interpretation |
|----|-------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

| "Affiliate"          |   | means      any company, partnership or other entity which directly or indirectly      Controls, is Controlled by or is under common Control with the relevant      Party to this Agreement. "Control" or "Controlled" means the      ownership of more than fifty per cent (50%) of the issued share capital or      the legal power to direct or cause the direction of the general management      and policies of the Party in question;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
|----------------------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                 |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| "Agreement"          |   | means      this Development and Supply Agreement and the Schedules hereto, as amended      or varied from time to time by written agreement of the      Parties;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |
|                 |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| "Batch"              |   | means      the total Product (Drug Substance) obtained from one fermentation and      associated purification using the Process.  Batches which are to      be produced in accordance with cGMP are also referred to as "cGMP      Batches";                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 |
|                 |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| "Batch      Release" |   | means      a release of any Batch by a Qualified Person for distribution or further      processing confirming that the Batch is in accordance with the relevant      requirements for human use (as defined in Directive 2001/83/EC for      medicinal products for human use);                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |
|                 |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| "Cell    Line"       |   | means      the cell line controlled by Micromet and selected by Micromet for the      production of the Product, particulars of which are set out in Schedule      1;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
|                 |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| "CEO"                |   | means      chief executive officer;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |
|                 |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| "cGMP"               |   | means      current good manufacturing practices and general biologics products      standards as promulgated under the European Commission Directives      91/356/EEC, as amended by Directive 2003/94/EC, and 91/412/EEC      respectively; the International Committee for Harmonisation (ICH) Q7A      Guideline on Good Manufacturing Practice for Active Pharmaceutical      Ingredients; the U.S. Federal Food, Drug and Cosmetic Act found in Title      21 of the U.S. Code of Federal Regulations (CFR), including but not      limited to Parts 210, 211 and Parts 11,  310 et seq., 600 to      610, the European Commission Guidelines of Good Manufacturing Practices      for Medicinal Products as promulgated under European Directive 2003/94/EC      (Eudralex – Volume 4) and the respective Japanese directives and      guidelines by the Japanese authorities, as applicable. Lonza meets EU GMP      requirements as defined in Eudralex - Volume 4 Good Manufacturing      Guidelines by the European Commission for medicinal products for human and      veterinary use (EU-GMP Guidelines); |
|                 |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
| "cGMP      Product"  |   | means      Product which is required under Schedule 2 to      be manufactured in accordance withcGMP;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |

----

| Execution      Copy |  |
|---------------------|--|

| "COO"                                          |   | means      chief operating officer;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
|------------------------------------------------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                           |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
| "Deliver",      "Delivered"      or "Delivery" |   | has      the meaning given to it in Clause 6;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |
|                                           |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
| "Deliverables"                                 |   | means      the reports, documentation, information, material and Product which Lonza      is to make available to Micromet during the Project. The Deliverables and      the timelines to provide the Deliverables are set forth in the Project      Plan in Schedules      8 A and 8 B hereto;                                                                                                                                                                                                                                                                                                                                   |
|                                           |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
| "Engineering      Batch"                       |   | means      the first Batch at scale after the pilot Batch in which Lonza will use      commercially reasonable efforts but does not warrant to meet      cGMP;                                                                                                                                                                                                                                                                                                                                                                                                                                                                    |
|                                           |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
| "External      Laboratories"                   |   | means      any Third Party instructed by Lonza, with Micromet’s consent, to conduct      activities required to complete the Works and Services, including but not      limited to, Third Parties that synthesise DNA or perform tests on the Cell      Line, Product or materials derived therefrom;[***]                                                                                                                                                                                                                                                                                                                  |
|                                           |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
| "Intellectual      Property"/"IP"              |   | means      all intellectual property rights, including (without limitation) patents,      patent applications, divisions, continuations, continuation-in-part      applications, divisionals, substitutions, confirmations, supplementary      protection certificates, reissues, utility models, trademarks, database      rights and copyrights and all inventions, know-how, trade secrets,      techniques and confidential information and other proprietary knowledge      and information which may subsist anywhere in the world, in each case for      their full term, and together with any renewals or    extensions; |
|                                           |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
| "Lonza"                                        |   | means      Lonza Sales AG and its Affiliates Lonza Biologics plc of Slough, England,      Lonza Biologics Inc of Portsmouth, NH, USA, and Lonza Biologics Porriño      S.L. of Pontevedra-Galicia, Spain, and their successors in title and      lawful assigns;                                                                                                                                                                                                                                                                                                                                                             |
|                                           |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
| "Lonza      Confidential Information"          |   | means      and includes Lonza Technology, any trade secrets or other confidential      information relating to Lonza's technology, business affairs or finances      of Lonza, or of any suppliers, agents, distributors, licensees or other      customers of Lonza and the commercial terms of this    Agreement;                                                                                                                                                                                                                                                                                                               |
|                                           |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
| "Lonza      Know How"                          |   | means      all technical and other information relating directly or indirectly to the      Lonza Process and/or the performance of the Works and Services, known to      Lonza from time to time, other than Micromet Confidential Information,      Micromet Know How and information in the public domain. Without limiting      the foregoing, the Lonza Know How is identified in Schedule      4hereto;                                                                                                                                                                                                                      |

----

| Execution      Copy |  |
|---------------------|--|

| "Lonza      Patent Rights"               |   | means      all patents, patent applications, divisions, continuations,      continuation-in-part applications, divisionals, extensions, substitutions,      renewals, confirmations, supplementary protection certificates and      reissues, throughout the world relating to the Lonza Process and/or the      performance of the Works and Services which from time to time Lonza is the      owner of or is entitled to use, and that is used in the performance of the      Works and Services. Without limiting the foregoing, the Lonza Patent      Rights as of the Effective Date are listed in Schedule      5 hereto; |
|------------------------------------------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| "Lonza      Process"                     |   | means      the proprietary process of Lonza, including any modifications and      improvements, which is used for the manufacture of the Product      hereunder;                                                                                                                                                                                                                                                                                                                                                                                                                                                                 |
|                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| "Lonza      Technology"                  |   | means      the Lonza Know How and the Lonza Patent Rights;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |
|                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| "[***]"                                  |   | means      [***];                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |
|                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| "[***]"                                  |   | means      the [***] Agreement between [***] and [***] dated [***] and attached      hereto at Schedule 9;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |
|                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| "Micromet"                               |   | means      Micromet AG and its existing Affiliates which are engaged in the research      and development of BiTE®      antibodies, and their successors in title and lawful    assigns;                                                                                                                                                                                                                                                                                                                                                                                                                                    |
|                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| "Micromet      Confidential Information" |   | means      and includes Micromet Materials, Micromet Technology and the Results, any      trade secrets or other confidential information relating to Micromet's      technology, development strategies, business affairs or finances of      Micromet, or of any licensors, suppliers, agents, distributors or other      contractors of Micromet, and the commercial terms of this      Agreement;                                                                                                                                                                                                                            |
|                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |
| "Micromet      Know How"                 |   | means      all technical and other information relating directly or indirectly to the      Micromet Process, the Cell Line and the Micromet Materials, known to      Micromet from time to time, other than Lonza Confidential Information,      Lonza Know How and information in the public domain. Without limiting the      foregoing, the Micromet Know How is identified in Schedule      6 hereto;                                                                                                                                                                                                                        |

----

| Execution      Copy |  |
|---------------------|--|

| "Micromet      Materials"     |   | means      the materials and documentation supplied by Micromet to Lonza (including      but not limited to [***]). Without limiting the foregoing, the Micromet      Materials to be transferred are listed in Schedule      1 hereto;                                                                                                                                                                                                                                                                                                                                                                                            |
|-------------------------------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
| "Micromet      Patent Rights" |   | means      all patents, patent applications, divisions, continuations,      continuation-in-part applications, divisionals, extensions, substitutions,      renewals, confirmations, supplementary protection certificates and      reissues, throughout the world relating to the Micromet Process, the Cell      Line and the Micromet Materials which from time to time Micromet is the      owner of or is entitled to use, and that is used in the performance of the      Works and Services. Without limiting the foregoing, the Micromet Patent      Rights as of the Effective Date are listed in Schedule      7 hereto; |
|                          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
| "Micromet      Process"       |   | means      the process (including but not limited to the [***]) for the production of      Product which is owned or Controlled by Micromet and made available to      Lonza hereunder [***], further improvement and/or production of the      Product;                                                                                                                                                                                                                                                                                                                                                                           |
|                          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
| "Micromet      Technology"    |   | means      the Micromet Know How and the Micromet Patent Rights;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |
|                          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
| "[***]"                       |   | means      [***], including [***];                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 |
|                          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
| "MT103"                       |   | means      Micromet's single-chain bispecific anti-CD19 antibody (CD19 BiTE®)      also known as Blinatumomab;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |
|                          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
| "Party"/"Parties"             |   | shall      mean Lonza or Micromet, or Lonza and Micromet, as the context      admits;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
|                          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
| "Price"                       |   | means      the price specified in Schedule      3 for the Works and Services;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |
|                          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
| "Process"                     |   | means      the process used by Lonza for the production of Product from the Cell Line      in accordance with this Agreement, which may [***] of the [***], and is      modified and/or improved hereunder;                                                                                                                                                                                                                                                                                                                                                                                                                        |
|                          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
| "Product"                     |   | means      MT103 manufactured under this Agreement (including any sample thereof),      particulars of which are set out in Schedule      1 and includes all derivatives thereof;                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
|                          |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
| "Project"                     |   | means      the program described in the ProjectPlan;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |

----

| Execution      Copy |  |
|---------------------|--|

| "Project      Manager"       |   | means      a Party's representative who is responsible for the coordination and      supervision of the Project in accordance with Clause 4.1      below;                                                                                                                                                                                                                                                                                                                                                                                                                                      |
|------------------------------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| "Project      Plan"          |   | means      the plan describing all activities to be performed under this Agreement,      including any update and amendment of the Project Plan the Parties may      agree from time to time, and attached hereto as Schedules      8 A and 8 B;                                                                                                                                                                                                                                                                                                                                               |
|                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| "Project      Team"          |   | means      the working group described in Clause 4.2;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |
|                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| "Qualified      Person"/"QP" |   | means      a person confirming that the Batch is in accordance with the relevant      requirements (as defined in Directive 2001/83/EC for medicinal products      for human use);                                                                                                                                                                                                                                                                                                                                                                                                             |
|                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| "Results"                    |   | means      the Product, any inventions, discoveries, know how, data, Deliverables,      documentation, reports, materials, writings, processes, methods and other      information, recorded in any form, that are discovered, conceived, reduced      to practice, developed or otherwise generated by Lonza, which are related      to the Works and Services and conceived through the performance of the      Works and Services, and any Intellectual Property pertaining to any of the      foregoing (including the [***]), provided,      however, that "Results" shall exclude [***]; |
|                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| "Service      Agreement"     |   | means      the agreement between the Parties dated September 28, 2009 regarding [***]      for the production of Product [***];                                                                                                                                                                                                                                                                                                                                                                                                                                                                |
|                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| "Specifications"             |   | means      the specifications for Drug Substance. The Specifications and the      specifications for Drug Product regarding the testing of Drug Product by      Lonza are set out in Schedule      2;                                                                                                                                                                                                                                                                                                                                                                                          |
|                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| "Steering      Committee"    |   | means      the committee described in Clause 4.3;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |
|                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| "Terms      of Payment"      |   | means      the terms of payment specified in Schedule      3;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |
|                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| "Third      Party"           |   | means      any party other than Lonza and Micromet;                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
|                         |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| "Works      and Services"    |   | means      all or any part of the works and services which are the subject of this      Agreement, particulars of which are set out in Schedules      8 A and 8B.                                                                                                                                                                                                                                                                                                                                                                                                                              |

----

| Execution      Copy |  |
|---------------------|--|

| 2. | Provision      of the Works and Services |
|----|------------------------------------------|

| 2.1 | Lonza      shall diligently carry out the Works and Services as provided in Schedule 8 A –      and in Schedule      8 B, once it is finalized - and shall use all reasonable efforts to      achieve the estimated timescales set out in that Schedule.  The      Parties agree that the Works and Services set forth in Schedule 8 B are      rough estimates only, and the Parties shall updated and refine such      Schedule 8 B after the transfer of the Micromet Materials and      establishment of the Process at Lonza.  Lonza shall perform the      Works and Services under this Agreement according to the current industry      standards and subject to terms and conditions as set out      herein.  Lonza shall at all times use reasonable and adequate      safety and protection measures to ensure, as far as is reasonably      possible, that the Results are not endangered by an interruption of      Lonza's research and developmentactivities. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.2 | Lonza      shall do all that is reasonably possible to meet the objectives under the      Project Plan, including diligence obligations and commercially reasonable      flexibility regarding alternative work packages and capacity reservations      under this Agreement. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.3 | Micromet      shall make available to Lonza a data package comprising the Micromet Know      How which is reasonably required to perform the Works and Services and the      Parties shall collaborate to assist Lonza in evaluating such Micromet Know      How.  Without undue delay upon completion of the Services      Agreement and delivery of such Micromet Know How, however, no later than      within [***] thereafter, Lonza shall inform Micromet whether the [***],      the [***] and the [***] meet the particulars set out in Schedule 1 and      are suited for the performance of the Works and [***].  If the      [***], the [***] and/or the [***] do not meet the particulars set out in      Schedule      1, Lonza and Micromet shall enter into good faith discussions in      order to identify a [***], a [***] or other [***] for the Works and      Services and to agree on the terms and conditions and adjustments to the      Project Plan to minimize any delay.  If the Parties are unable      to agree on an [***] or [***] and the [***] after completion of the later      of (i) completion of services under the Services Agreement or (ii)      transfer of the Micromet Materials and Micromet Technology,      [***]. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.4 | Lonza      shall manufacture cGMP Product to meet the Specifications [***] manufactured or      in respect of the [***].  If the [***] or a combination of the      [***] and the [***] is used, then in addition to the above, Lonza shall be      under no obligation to meet [***] [***].  In the event the [***]      does not meet the Specifications, the Parties shall promptly meet through      the Steering Committee to discuss and agree on how to ensure that the      Specifications can be met, which agreement may include a modification of      the Project Plan. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.5 | Owing      to the unpredictable nature of the biological processes involved in the      Works and Services, the timescales set down for the performance of the      Works and Services (including without limitation the dates for production      and Delivery of Product) and the quantities of Product for Delivery set      out in Schedules      8 A and 8 B are estimated only.  In the event any Party      realizes that the Project Plan needs to be changed, e.g., for a delay of      Works and Services owing to technical or scientific difficulties, such      Party shall immediately inform the Project Team hereof and the Parties,      through the Steering Committee (if needed), shall use commercially      reasonable efforts to come to an adequate solution and agree on an      adequate amendment of the Project Plan.  In particular, Lonza      will use commercially reasonable efforts to [***] as early as possible, in      the event any of the [***], provided always that      [***] are taken into account. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

| 2.6 | Lonza      will use its reasonable efforts to perform any additional work which may      become necessary to manufacture Product for [***].  If such      additional work leads to additional costs, Lonza will provide a quotation      for such additional work.  In case the Parties agree on the      additional work and the costs for such additional work, Lonza shall      perform additional work to sustain the progress of the Project on terms      and conditions to be agreed by the Parties and defined in an amendment to      the Project Plan.  If further quantities of Product are required      [***] which are not part of this Agreement, the Parties will discuss in      good faith how Lonza can satisfy Micromet's needs for such additional      quantities. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.7 | Without      prejudice to Lonza’s obligations under Clauses 2.1 and 2.2 and the      termination rights under Clause 12, Micromet [***] of the Works and      Services or to [***] on grounds of late performance, late Delivery or      failure to produce the estimated quantities of Product for      Delivery.  Lonza shall not be liable for any loss, damage, costs      or expenses of any nature, whether direct or consequential, occasioned      by: |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a)  | [***];      or |
|--------|-----------|----------------|

|   | (b)  | [***]. |
|--------|-----------|--------|

| 2.8 | Lonza      shall comply with all applicable laws and regulations regarding the cGMP      production, including but not limited to the EU-GMP Guidelines (Eudralex –      Vol. 4), FDA regulations, Japanese regulations and the International      Committee for Harmonisation regulatory requirements from time to time      applicable to the Works and Services as set out in Schedules 8 A and 8      B. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.9 | Lonza      shall not use the Cell Line, the Process (not including the Lonza      Process), the Micromet Materials or the Micromet Technology (or any part      thereof) for any purpose other than the performance of the Works and      Services under this Agreement. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.10  | Lonza      shall: |
|------------|-------------------|

|   | (a) | at      all times use all reasonable endeavours to keep the Cell Line and/or the      Micromet Materials secure and safe from loss and damage in such manner as      Lonza stores its own material of similar nature during the term of this      Agreement, and obtain and maintain an appropriate insurance against the      risks of loss and damage; |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (b) | during      the performance of the Works and Services, inform Micromet as soon as      reasonably possible upon request about all ongoing    activities; |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (c) | not      part with possession of the Cell Line and/or the Micromet Materials or the      Product, save for the purpose of activities at the External Laboratories      or as otherwise authorised in writing by  Micromet; |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (d) | store      Micromet Materials in accordance with applicable laws, industry standards      and the specifications set forth in Schedule 1,      furthermore, store the Cell Line and the cell banks ([***]) at at least      two (2) different and controlled sites under cGMP    conditions; |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

|   | (e) | audit      all External Laboratories in accordance with GxP guidelines and confirm      the performance of such audit to Micromet in writing;  and |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (f) | procure      that all External Laboratories are subject to obligations of confidence      substantially in the form of those obligations of confidence imposed on      Lonza under this Agreement. |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.11 | Lonza      will not (i) directly or indirectly, take any steps to ascertain [***]      provided by Micromet and or a [***], and (ii) use Micromet's [***] for any      purpose other than manufacturing the Product.  In the event      Lonza ascertains or receives the recipe of any of Micromet's [***] through      no fault of its own, Lonza shall promptly inform Micromet of such event      and destroy such information. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.12 | Lonza      and Micromet will exchange details of [***].  Lonza will obtain      Micromet's consent regarding [***], which Micromet shall not unreasonably      withhold.  Lonza shall use reasonable commercial endeavours to      ensure continuity of supply, [***]. |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.13 | Lonza      agrees to maintain proper records (the "Records") in respect of      its performance of the Works and Services, including any Results made as      part of the Works and Services.  Upon written request by      Micromet, Lonza shall provide copies of the Records or any part(s)      thereof, redacted with regards to [***] and [***] to      Micromet.  As part of keeping the Records, Lonza shall ensure      that all of its personnel and all of its agents abide by the regulations      of the International Committee for Harmonisation as per Clause      2.8. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.14 | Lonza      shall: |
|------|-------------------|

|   | (a) | make      available to Micromet the Deliverables set forth in the Project      Plan; |
|--------|-----|--------------------------------------------------------------------------------------|

|  | (b) | make      available to Micromet (i) upon completion of any milestone as outlined in      the Project Plan and or (ii) [***] and upon reasonable request of      Micromet, (i.e., if Micromet requires such documentation for regulatory      purposes or for own development purposes andprovided that such      documentation – in Lonza's reasonable opinion – is accurate); copies of      all relevant documentation and information resulting from the Works and      Services and relating to the Product in order to enable Micromet to      evaluate the status and to meet any statutory or regulatory      requirements.  The documentation and information shall be      provided in the CTD format.  The documentation and information      shall include but not be limited to[***]; |
|--|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (c) | support      IND updates and CTAs as well as the submission of dossiers for NDA/MAA      approval; |
|--------|-----|----------------------------------------------------------------------------------------------------|

|   | (d) | make      available to Micromet, upon completion of each stage as outlined in the      Project Plan and upon request of Micromet, material ([***]) resulting from      the Works and Services in order to enable Micromet to test the      supernatant, antibody, cells, Product, and the  like; |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (e) | assist      Micromet in respect to regulatory requirements concerning the CMC-part,      including but not limited to the[***]; |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------|

|   | (f) | reasonably      support Micromet regarding regulatory matters.  Such support      shall include an obligation to make Micromet aware of any specific      regulatory requirements relating to Lonza’s activities, to accompany      Micromet to meetings with the regulatory authorities upon [***] prior      written notice by Micromet (or use reasonable commercial endeavours to      support Micromet where shorter notice is provided by a regulatory      authority), to prepare such meetings jointly with Micromet, and to      actively participate in scientific advice meetings;  and |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

|   | (g) | promptly      inform Micromet about any [***]. |
|--------|-----|------------------------------------------------|

|   | The      Deliverables and the provision of the Deliverables are defined in more      detail in the Project Plan. |
|--------|------------------------------------------------------------------------------------------------------------------|

| 2.15 | Lonza      shall from time to time offer to Micromet [***] [***] (as identified in      Schedule 4).  Such new version shall be made available at the      price set forth in the Technology Transfer and License Agreement in Schedule 14      hereto, if applicable, with the only further compensation being for      additional Works and Services which may be required to implement such      improvement or new version for the manufacture of the    Product. |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 2.16 | Any      subcontracting of Works and Services to be performed hereunder by Lonza to      Third Parties requires the prior written consent of    Micromet. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3. | Micromet's      Obligations |
|----|-----------------------------|

| 3.1 | Following      the Effective Date (if not already forwarded to Lonza during the Services      Agreement) and upon conclusion of [***] attached hereto as Schedule 9,      Micromet shall supply to Lonza the Micromet Know How, together with full      details of any hazards relating to the Cell Line, the Micromet Process      and/or the Micromet Materials, their storage and use, in each case, to the      extent required by Lonza to perform the Works and Services.  For      the avoidance of doubt, the [***] is embodied in the [***] and is not      disclosed as a separate set of documents.  On review and      approval by Lonza’s safety committee of this Micromet Technology, the Cell      Line, the Micromet Process and/or the Micromet Materials shall be provided      to Lonza at Lonza’s request.  Property in the Cell Line, the      Micromet Process and/or the Micromet Materials and/or the Micromet      Technology supplied to Lonza shall remain vested in    Micromet. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.2 | Unless      the Parties agree otherwise during the term of this Agreement, Micromet or      Micromet's Third Party supplier will supply to Lonza the [***] necessary      for the manufacture of Product.  Lonza shall not, directly or      indirectly, take any steps to [***] provided by      Micromet.   Similarly, should the Lonza Process be used in      the manufacture of the Product, Micromet shall not, directly or      indirectly, take any steps to [***] provided by  Lonza. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.3 | Micromet      shall pay the Price set out in Schedule 3 for      provision of the Works and Services together with any additional costs and      expenses that fall due under this Agreement in accordance with the Terms      of Payment. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.4 | Micromet      hereby grants Lonza the non-exclusive right to use the Cell Line, the      Micromet Process, the Micromet Materials, and the Micromet Technology      during the term of this Agreement and solely for the purpose of this      Agreement.  Micromet acknowledges that Lonza does not require a      separate licence to Micromet Confidential Information as all necessary      licences are contained in the first sentence of this clause      3.4. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

| 3.5 | From      time to time, as soon as reasonably possible and with at least [***]      advance notice, Lonza may submit to Micromet a written request to provide      or have provided consulting services to Lonza with respect to the Micromet      Process, which request will include the specifics of the consulting      services being requested, and Micromet will use reasonable efforts to      provide or have provided such consulting  services. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 4.  | Governance |
|----------|------------|

| 4.1 | Designation of Project      Manager:  Lonza and Micromet shall each identify a      Project Manager who will be responsible for the coordination and      supervision of the Project including communication of all instructions and      information concerning the Project to the other Party.  A      written protocol of such communication shall be provided by the Project      Managers.  Each Project Manager will be available on an agreed      weekly basis for consultation at prearranged times during the course of      the Project.  In the absence of the Project Manager, a      substitute shall be appointed.  Additional modes or methods of      communication and decision making may be implemented with the written      consent of each Party. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 4.2 | Project      Team:  The Parties shall form a Project Team to which      Micromet will delegate professionally and technically qualified      representatives (e.g., qualified in upstream process, downstream process,      analytics, quality assurance and regulatory matters).  Each      Project Team member shall have knowledge and ongoing familiarity with the      Project and will possess the authority to make decisions on matters raised      in the Project Team.  Each Party shall have the right to      substitute different representatives as its members of the Project Team as      needed from time to time.  Each Party shall also be entitled to      invite other employees as ad hoc guests to address specific technical or      commercial issues related to the Project.  Consultants of a      Party or other Third Parties may be invited, provided that they are      bound by a confidentiality obligation which is substantially similar to      the Parties' obligations under Clause 10below. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | The      Project Team shall oversee the Project.  Prior to each meeting      of the Project Team the Parties will distribute to each other written      copies of all materials, data and information arising out of the conduct      of their activities hereunder.  Unless otherwise agreed, Lonza      shall present any suggestions regarding the Project Plan and/or      specifications of the Project to the Project Team for discussion and      approval by Micromet. |
|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Each      Party shall bear its own travel and accommodation costs.  The      meetings of the Project Team may also be held by telephone or video      conference if mutually agreed by the Project Team members.  It      is the right of each Party to call for a Project Team meeting upon written      request at any time.  In that case the meeting will be held at a      time and location to be agreed between the Project Team      members. |
|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | The      inviting Party shall prepare minutes of the meeting which shall be      circulated promptly following themeeting. |
|--------|----------------------------------------------------------------------------------------------------------------------------|

| 4.3 | Steering      Committee:  The Parties shall form a Steering Committee      to which each Party will delegate two (2) executive employees, who are      familiar with the Project.  The Steering Committee shall have      general oversight and review of the activities of the Project Team and      shall be responsible for resolving any issues referred to the Steering      Committee by the Parties. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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| Execution      Copy |  |
|---------------------|--|

|   | The      Steering Committee shall meet in person or via teleconferences within      [***] after a written request by either Party to the other Party, or      sooner, if required, and calendar quarterly, if possible towards the end      of a stage of the Project.  The request shall describe the      matter in dispute and the solution which the requesting Party proposes to      be decided. |
|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | The      Steering Committee will take action by unanimous consent of its members,      with each representative having a single vote, or by a written resolution      signed by all of the representatives.  If the Steering Committee      is unable to reach unanimous consent on a particular matter, then the      matter will be referred to a personal face-to-face meeting between Lonza's      [***] and the [***] of Micromet, who in each case may not be a member of      the Steering Committee and both of whom shall act in good faith and      discuss the issue to seek a resolution amicably acceptable to both Parties      and if resolved the resolution shall be binding and final.  The      meeting shall take place within [***] of the relevant      referral.  In case such persons cannot agree within further      [***] after such face-to-face meeting, then the following shall      apply: |
|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (i) | If      the dispute is predominantly concerned with scientific or technical issues      then [***]:  [***].  The Parties will make available      the same set of documents to [***] and both experts shall provide [***] in      English language within [***] after the [***] has been      [***].  If [***] experts come to dissenting opinions and are      unable to solve the dispute among themselves, [***] shall be appointed      [***], if the Parties cannot agree, [***].  Such [***] shall      have access to the written opinions of [***] as well as to all documents      which were made available to [***].  The [***] shall then [***]      of [***], and such opinion [***] shall be considered final and binding on      the Parties except if there has been a manifest error on the face of the      decision whereupon the Parties may revert to their respective remedies      under Clause 16 below.  The reasonable costs of [***] shall be      paid or refunded, as the case may be, by the non-prevailing      Party. |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (ii) | If      the dispute is predominantly concerned with an issue other than scientific      or technical then it shall be resolved in accordance with Clause 16      below. |
|--------|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5.  | Inspections;      Person in Plant |
|----------|-----------------------------------|

| 5.1 | As      more fully set out in the Quality Agreement in Schedule 10      hereto, Lonza grants to Micromet and/or its consultant the right to      inspect and audit Lonza's Affiliate’s facility located in Slough,      Berkshire, United Kingdom ("Facility") as well as      the documentation generated in connection with the manufacture and testing      of Product including all relevant standard operating procedures.       Lonza grants the right to perform [***] cGMP compliance audit per year,      [***] at a time mutually agreed between Micromet and Lonza.  Micromet      can perform [***] cGMP batch documentation audit per cGMP batch which      would be scheduled as appropriate in the project plan.  Moreover,      Micromet is entitled to perform additional audits in the event of      complaints, major or critical deviations or other enquiries by regulatory      authorities without any fee, and if necessary, on short-term notice.       Micromet will discuss the results of any inspection with      Lonza.  Any inspection by Micromet does not relieve Lonza of its      obligations to comply with all applicable laws and does not constitute a      waiver of any right otherwise available to Micromet.  As more fully      set out in Clause 5.3, [***] is also entitled to attend all production      campaigns of the Product at theFacility. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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| Execution      Copy |  |
|---------------------|--|

| 5.2 | As      more fully set out in the Quality Agreement in Schedule 10      hereto, an employee and/or consultant and /or successor of Micromet or      Micromet’s sublicensee(s) of the Product will have the right to be present      [***]. Furthermore, Lonza will inform Micromet of the results of any      inspection by a regulatory authority (subject to any restraints placed on      Lonza by such regulatory authority, Lonza Confidential Information which      Micromet does not require for purposes of this Agreement or customer      confidentiality) that does or could reasonably be expected to affect the      manufacture of Products. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5.3 | Lonza      agrees to have an employee or consultant of Micromet be present at the      Facility in order to observe the Works and Services performed by Lonza or      its Affiliate ("Person-in-Plant" or      "PiP") in      accordance with this Clause 5.3.  Upon request of Micromet,      Lonza shall grant the PiP access to the Facility where the Works and      Services are performed.  Such visits, shall last [***], will      take place [***] during regular business hours and [***] prior notice to      Lonza, provided,      however, that PiP will be entitled to perform additional visits      that could [***] manufacturing process subject to Lonza’s consent not to      be unreasonably withheld or delayed, and further providedthat PiP will be      entitled to perform visits upon immediate notice in the event of      complaints or failures which may endanger the  Project. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5.4 | Notwithstanding      Clauses 5.1, 5.2 and 5.3, Micromet acknowledges and accepts that the      Facility is a multi-customer facility, and that the PiP’s movement about      and access to the Facility may be restricted and shall be subject to      supervision by Lonza. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6.  | Delivery,      Transportation of Product andTesting |
|----------|-----------------------------------------------------|

| 6.1 | Subject      to Clause 2.4, Product shall be Delivered in accordance with the      Specifications.  Delivery shall be made [***] (as defined by      Incoterms 2000) which means (a) [***] and (b) [***].  Subject to      Clause 6.2, Lonza shall deliver to Micromet the Certificate of Analysis,      the Certificate of Compliance, issued by and in responsibility of a      Qualified Person (Batch Release) and such other documentation as is      reasonably required to meet all applicable statutory and regulatory      requirements not later than the date of      Delivery.  Transportation of Product, whether or not under any      arrangements made by Lonza on behalf of Micromet,  [***]. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6.2 | At      Micromet's request, Lonza will Deliver Product [***].  Such      request shall be accompanied by Micromet's written acknowledgement that      the Product has been Delivered without the transmittal to Micromet of the      Certificate of Analysis and the Batch release documents (QP release), that      accordingly the Product cannot be administered to humans until transmittal      of the Certificate of Analysis, Certificate of Compliance (possibly in one      document) and the Batch release documents (QP release) and that Micromet      nevertheless accepts full risk of loss, title and ownership of the      Product.  The Delivery of Product in quarantine shall be subject      to such testing requirements as Lonza may reasonably require, and the      [***] period referred to in Clause 6.9 shall run from Delivery in      quarantine of the Product toMicromet. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6.3 | Unless      otherwise agreed, Lonza shall package and label Product for Delivery in      accordance with its standard operating procedures.  It shall be      the responsibility of Micromet to inform Lonza in writing in advance of      any special packaging and labeling requirements for      Product.  All additional costs and expenses of whatever nature      incurred by Lonza in complying with such special requirements shall be      charged to Micromet in addition to thePrice. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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| Execution      Copy |  |
|---------------------|--|

| 6.4 | If      requested in writing by Micromet, Lonza will (acting as agent for      Micromet) arrange for storage in accordance with the storage conditions in      Schedule      1 and for insurance of Product whilst held by Lonza after Delivery      (awaiting transportation) for up to [***] after QP release of the Batch,      and in exceptional cases for a maximum of [***], on terms equivalent to      those under which Lonza stores and insures product prior to      Delivery.  All additional costs and expenses of whatever nature      incurred by Lonza in arranging such storage and insurance shall be charged      to Micromet in addition to thePrice. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6.5 | If      requested in writing by Micromet, Lonza will (acting as agent of Micromet      for such purpose) [***] together with [***] for Product in transit at its      invoiced value.  All [***] of whatever nature    [***]. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6.6 | Where      [***], Micromet shall diligently examine the Product as soon as      practicable after receipt.  Notice of all claims (time being of      the essence) arising out of: |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a) | visible      damage (i.e., visible without inspection and testing) to or total or      partial loss of Product in transit shall be given in writing to Lonza and      the carrier within [***] of receipt by Micromet;  or |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (b) | non-Delivery      shall be given in writing to Lonza within [***] after the date of Lonza’s      dispatch notice. |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------|

| 6.7 | Any      Product Delivered hereunder shall, at the time of Delivery conform      [***]  Lonza and Micromet shall use all commercially reasonable      efforts to resolve a non-conformity issue and resume re-delivery of      Products at the earliest time possible.  Any dispute regarding      the conformity of Products which cannot be settled within [***] after      receipt of a detailed written notice of rejection shall be submitted for      resolution to the SteeringCommittee. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6.8 | Micromet      shall make damaged Product and associated packaging materials available      for inspection and shall comply with the requirements of any insurance      policy covering the Product notified by Lonza to      Micromet.  Lonza shall offer Micromet all reasonable assistance      (at the cost and expense of Micromet) in pursuing any claims arising out      of the transportation of Product. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6.9 | Promptly      following receipt of Product or any sample thereof, Micromet may carry out      any of the agreed tests outlined or referred to in Schedule      11.  Subject to Clause 2.4, if such tests show that the      Product fails to meet Specifications, Micromet shall give Lonza written      notice thereof within [***] from the date of Delivery and shall return      samples of such Product to Lonza’s premises for further testing and      Micromet shall store the remainder of Product in quarantine.  In      the absence of such written notice and subject to any hidden defect which      did not appear in the tests carried out by Micromet in accordance with      Schedule      11, Product shall be deemed to have been accepted by Micromet as      meeting the Specifications.  Subject to Clause 2.4, if Product      returned to Lonza fails to meet the Specifications and if such failure is      not due (in whole or in part) to acts or omissions of Micromet or any      Third Party after Delivery, [***]. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6.10 | Subject      to Clause 2.4, if there is any dispute concerning whether Product returned      to Lonza fails to meet the Specifications or whether such failure is due      (in whole or in part) to acts or omissions of Micromet or any Third Party      after Delivery, such dispute shall be referred for decision to [***] in      accordance with Clause 4.3 (i)above. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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| Execution      Copy |  |
|---------------------|--|

| 6.11 | The      provisions of Clauses 6.9 and 6.10 shall be the sole remedy available to      Micromet in respect of Product that fails to meet the      Specifications. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 7.  | Price      and Terms of Payment |
|----------|---------------------------------|

| 7.1 | Unless      otherwise indicated in writing by Lonza, all prices and charges are      exclusive of Value Added Tax or of any other applicable taxes, levies,      imposts, duties and fees of whatever nature imposed by or under the      authority of any government or public authority, which shall be paid by      Micromet (other than taxes on Lonza’s income).  Payments shall      be made in accordance with the Terms of Payment in Schedule 3      hereto.  Lonza will provide to Micromet in regular intervals      upon amendments to the Project Plan updated payment plans.  All      invoices are strictly net and payment must be made within [***] of date of      invoice.  Payment shall be made without deduction, deferment,      set-off, lien or counterclaim of anynature. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 7.2  | In      default of payment on due date: |
|-----------|-----------------------------------------|

|   | (a) | interest      shall accrue on any amount overdue at the rate of [***] above the base      lending rate from time to time of National Westminster Bank plc, interest      to accrue on a day to day basis both before and after judgment;      and |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (b) | Lonza      shall, at its sole discretion, and without prejudice to any other of its      accrued rights, be entitled to suspend the provision of the Works and      Services or to treat this Agreement as repudiated on not less than [***]      prior notice in writing to Micromet given at any time      thereafter. |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 8.  | Intellectual      Property |
|----------|----------------------------|

| 8.1 | Neither      Party will, as a result of this Agreement, acquire any right, title, or      interest in any Intellectual Property that the other Party owns or      Controls as of the Effective Date, or that the other Party obtains      ownership or Control of separate and apart from the performance of the      Works and Services under thisAgreement. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 8.2 | [***]. |
|-----|--------|

| 8.3 | [***]      shall own all right, title and interest in [***], which as used in this      Agreement means Intellectual Property that [***], contractors or agents      develops, conceives, invents, reduces to practice or makes in the course      of performance of the Works and Services and that (i) arises from or      relates to [***] or [***]; and (ii) is severable from the [***] and [***];      and (iii) does not reveal or disclose the [***], or Works and Services      performed under this Agreement.  [***] shall provide [***] with      a general description of any [***] in the event that any is developed, in      order to enable [***] to make an assessment as to whether [***] would like      to use the [***] under the [***]. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 8.4 | Except      for and not including the [***], [***] shall own all right, title, and      interest in [***]. |
|-----|------------------------------------------------------------------------------------------------------------|

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| Execution      Copy |  |
|---------------------|--|

| 8.5 | In      relation only to the [***] and [***] (and no other product), [***] hereby      grants [***], and [***] hereby accepts [***] under and to all [***], to      the extent such [***] are necessary or useful to research, develop, have      developed, conduct clinical trials for, formulate, manufacture, have      manufactured, test, seek regulatory approval for, market, have marketed,      commercialize, have commercialized, make, have made, use, sell, have sold      import, have imported and distribute and have distributed [***] or      [***].  For the avoidance of doubt, the nature of [***] is as      follows: |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | · | [***]      ownership of [***] as set out [***] is not  affected; |
|--------|--------|------------------------------------------------------------------|

|   | · | [***]      use of the [***] is limited to use on the [***] and [***];    and |
|--------|--------|------------------------------------------------------------------------------|

|   | · | [***]      can grant further licences of the [***] to any third party, but may not do      so in relation to the [***] and the[***]. |
|--------|--------|--------------------------------------------------------------------------------------------------------------------------------------|

| 8.6 | The      Parties shall reasonably assist each other in defending themselves against      a Third Party claim which would impair the exploitation of [***] Patent      Rights, [***] and/or [***] for the production of the      Product.  Each Party shall furnish the other with timely written      notice of any and all infringements and other unauthorized uses by any      other person, firm, corporation or other entity of any of [***] Patent      Rights, [***] or [***].  Furthermore, the Parties shall promptly      inform each other in the event either Party receives notice from any Third      Party or becomes otherwise aware that the [***] Patent Rights, the [***]      or the [***] may infringe Third Party Intellectual    Property. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 8.7 | In      relation only to the [***] and [***] (and no other product), to the extent      that Lonza Technology (a) is incorporated within the [***] or [***], or      (b) has been used in the manufacture of the [***] or [***], Lonza hereby      grants Micromet, and Micromet hereby accepts a [***] license under and to      Lonza Technology, to research, develop, have developed, conduct clinical      trials for, formulate, manufacture, have manufactured, test, seek      regulatory approval for, market, have marketed, commercialize, have      commercialized, make, have made, use, sell, have sold import, have      imported and distribute and have distributed [***] or      [***].  For the avoidance of doubt, the nature of the above      licence is as follows: |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (i) | Lonza’s      ownership of Lonza Technology is not affected, and except as set out in      item (iv) below, [***]; |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------|

|   | (ii) | There      is no [***] to Micromet; |
|--------|------|-------------------------------------|

|   | (iii) | Micromet’s      use of the Lonza Technology is limited to use on the Product and Modified      Product; and |
|--------|-------|-------------------------------------------------------------------------------------------------------------------|

|   | (iv) | Lonza      shall not [***] [***]. |
|--------|------|-----------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

| 9.  | Warranties      and Indemnification |
|----------|-------------------------------------|

| 9.1  | Lonza      warranty:  Lonza warrantsthat: |
|-----------|-----------------------------------------------------|

|   | (a) | the      Works and Services shall be performed in accordance with Clause      2; |
|--------|-----|----------------------------------------------------------------------------------|

|   | (b) | unencumbered      title (save for any Intellectual Property which may exist) to Product and      Results will be conveyed to Micromet upon  Delivery; |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (c) | on      the Effective Date the Lonza Technology is owned by Lonza or Lonza is      otherwise entitled to use it for the purposes of providing Works and      Services under this Agreement and during the term of this Agreement Lonza      shall not do or cause anything to be done which would adversely affect      their ownership or entitlement to use the same for those      purposes; |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (d) | Lonza      has the necessary corporate authorisations to enter into this      Agreement; |
|--------|-----|------------------------------------------------------------------------------------------|

|   | (e) | [***]; |
|--------|-----|--------|

|   | (f) | [***]; |
|--------|-----|--------|

|   | (g) | on      the Effective Date to the best of Lonza’s knowledge and belief, the use by      Lonza of the Lonza Process (excluding any modifications or steps made or      developed by Micromet, the Micromet Materials and Micromet Technology) and      Lonza Technology for the performance of the Works and Services as provided      herein will not infringe any rights (including without limitation any      intellectual or industrial property rights) vested in any Third Party      (provided, however,      that Micromet shall waive any breach of this warranty which arises      if a court of competent jurisdiction determines that the use by Lonza of      the Lonza Process, the Lonza Technology for the Works and Services      infringes the Intellectual Property of a Third Party, providedthat and for so long as      Lonza actually indemnifies Micromet pursuant to Clause 9.4      below); |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (h) | subject      to Clause 2.4, the Product will meet the  Specifications; |
|--------|-----|------------------------------------------------------------------------|

|   | (i) | Lonza      shall not use the Micromet Confidential Information, Micromet Materials,      the Micromet Technology, the Process and the [***] for any purposes other      than the Works and Services to be performed for Micromet hereunder;      and |
|--------|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (j) | Lonza      will notify Micromet in writing immediately if it receives or is notified      of a claim from a Third Party that the use by Lonza of the Process and/or      the Lonza Technology or [***] for Works and Services infringes any      Intellectual Property vested in such Third  Party. |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.2  | Micromet      warranty:  Micromet warrants  that: |
|-----------|-------------------------------------------------------------|

|   | (a) | on      the Effective Date to the best of Micromet's knowledge and belief,      Micromet has the right to supply the Cell Line, the Micromet Process, the      other Micromet Materials and the Micromet Technology to Lonza and the      necessary rights to licence or permit Lonza to use the same for the      purpose of the Works and Services; |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

|   | (b) | Micromet      has the necessary corporate authorisations to enter into this      Agreement; |
|--------|-----|---------------------------------------------------------------------------------------------|

|   | (c) | any      of the Cell Line, the Micromet Process, other Micromet Materials, and      Micromet Technology not owned by Micromet are licensed to Micromet under a      licence which will permit their use by Lonza to perform the Works and      Services; |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (d) | Micromet      has the right to disclose the Micromet Confidential Information and to      allow the use of the Micromet Confidential Information by Lonza for the      purposes of and in accordance with the terms of this Agreement, and the      disclosure of the Micromet Confidential Information from Micromet to Lonza      and the use of such Micromet Confidential Information by Lonza in      accordance with the terms of this Agreement does not constitute      [***]; |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (e) | Micromet      has agreed to indemnify [***] regarding the transfer of Micromet      Technology and Micromet Materials and such indemnification obligations      correspond to (or go beyond) the obligations in Section 3.6 of the      [***]; |
|--------|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (f) | on      the Effective Date and to the best of Micromet's knowledge and belief, the      timescales as set out in the Project Plan are realistic and Micromet will      be able to provide the Micromet Technology and the Micromet Materials to      perform the Works and Services in a timely  manner; |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (g) | on      the Effective Date and to the best of Micromet's knowledge and belief, no      additional work is required to achieve the  Deliverables; |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (h) | on      the Effective Date and to the best of Micromet's knowledge and belief, the      use by Lonza of the Cell Line, the Micromet Process, other Micromet      Materials and the Micromet Technology for the Works and Services      (including without limitation the manufacture of the Product and excluding      any modifications or steps made or developed by Lonza and the Lonza      Technology) will not infringe any Intellectual Property of any Third Party      (provided, however,      that Lonza shall waive any breach of this warranty which arises if      a court of competent jurisdiction determines that the use by Lonza of the      Cell Line, other Micromet Materials or the Micromet Technology for the      Works and Services infringes the Intellectual Property of a Third Party,      provided that and      for so long as Micromet actually indemnifies Lonza pursuant to Clause 9.5      below); |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (i) | the      Micromet Process had been used to manufacture Product in accordance with      cGMP and the Specifications; and |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------|

|   | (j) | Micromet      will promptly notify Lonza in writing if it receives or is notified of a      claim from a Third Party that the Cell Line, the Micromet Process, other      Micromet Materials, the Micromet Confidential Information, Micromet      Technology or that the use by Lonza thereof for the provision of the Works      and Services infringes any Intellectual Property of such Third      Party. |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | For      the avoidance of doubt, Section 3.3 of the [***] does in no way limit the      warranties given under this Clause9.2. |
|--------|--------------------------------------------------------------------------------------------------------------------------------|

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| Execution      Copy |  |
|---------------------|--|

| 9.3 | Disclaimer:  THE      WARRANTIES EXPRESSLY SET FORTH IN THIS AGREEMENT ARE IN LIEU OF ALL OTHER      WARRANTIES, AND, EXCEPT FOR THE WARRANTIES EXPRESSLY SET FORTH IN THIS      AGREEMENT, ALL OTHER WARRANTIES, BOTH EXPRESS AND IMPLIED, ARE EXPRESSLY      DISCLAIMED, INCLUDING WITHOUT LIMITATION ANY WARRANTY OF MERCHANTABILITY      OR FITNESS FOR A PARTICULARPURPOSE. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.4 | Indemnification by      Lonza: Subject to Clause 9.6 below, Lonza shall defend,      indemnify and hold harmless each of Micromet, its Affiliates, and their      directors, officers, and employees and the successors and assigns of any      of the foregoing (each a "Micromet Indemnitee")      from and against any Third Party claims, actions, liabilities, costs and      expenses (including court costs and legal fees on a full indemnity basis)      that Micromet may suffer arising directly outof |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a) | any      breach of the warranties given by Lonza in Clause 9.1 above;      or |
|--------|-----|-------------------------------------------------------------------------------|

|   | (b) | any      claims alleging that Lonza’s use of the Lonza Process (i.e., claims which      do not allege that the Micromet Process is infringing), the Lonza      Technology and/or [***] (i.e., claims which do not allege that the use of      [***] and/or the [***] is infringing) infringes any rights (including      without limitation any Intellectual Property) vested in a Third Party      (whether or not Lonza knows or ought to have known the same), provided that there      shall be excluded from this indemnity all Micromet revenue;    or |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (c) | any      negligent or willful act or omission of Lonza in relation to the      Product. |
|--------|-----|-----------------------------------------------------------------------------------------|

| 9.5 | Indemnification by      Micromet:  Subject to Clause      9.6 below, Micromet shall defend, indemnify and hold harmless each of      Lonza, its Affiliates, and their directors, officers, and employees and      the successors and assigns of any of the foregoing (each a "Lonza Indemnitee") from      and against any Third Party claims, actions, liabilities, costs and      expenses (including court costs and legal fees on a full indemnity basis),      that Lonza may suffer arising directly outof |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a) | any      breach of the warranties given by Micromet in Clause 9.2 above;      or |
|--------|-----|----------------------------------------------------------------------------------|

|   | (b) | any      claims alleging Lonza’s use of the Cell Line, the Micromet Process, the      Micromet Materials or the Micromet Technology infringes any rights      (including, without limitation, any Intellectual Property) vested in any      Third Party (whether or not Micromet knows or ought to have known about      the same) provided      that there shall be excluded from this indemnity all Lonza actual      or potential revenues other than those which are an integral part of any      Price or fees which Micromet is obliged to pay to Lonza under this      Agreement; or |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (c) | any      negligent or wilful act or omission of Micromet in relation to the      Product; or |
|--------|-----|----------------------------------------------------------------------------------------------|

|   | (d) | any      claims raised by [***] against Lonza under Section 3.6 (b) and/or (c) of      the [***], and any claims resulting from an early termination of the [***]      by [***], provided that Micromet is not required to indemnify Lonza of      such claims under Clause 9.4 above. |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

| 9.6 | Indemnification      Procedure: If a Lonza Indemnitee or Micromet Indemnitee (the      "Indemnitee")      intends to claim indemnification under this Clause 9, it shall promptly      notify the other Party (the "Indemnitor") in writing      of such alleged liability.  The Indemnitor shall have the right      to control the defence thereof with counsel of its choice as long as such      counsel is reasonably acceptable to Indemnitee; provided, however, that      any Indemnitee shall have the right to retain its own counsel at its own      expense, for any reason, including if representation of any Indemnitee by      the counsel retained by the Indemnitor would be inappropriate due to      actual or potential differing interests between such Indemnitee and any      other Party reasonably represented by such counsel in such      proceeding.  The Indemnitee, its employees and agents, shall      reasonably cooperate with the Indemnitor and its legal representatives in      the investigation of any liability covered by this Clause      9.  The obligations of this Clause 9.6 shall not apply to      amounts paid in settlement of any claim, demand, action or other      proceeding if such settlement is effected without the consent of the      Indemnitor, which consent shall not be withheld or delayed      unreasonably.  The failure to deliver written notice to the      Indemnitor within a reasonable time after the commencement of any such      action, if prejudicial to its ability to defend such action, shall relieve      the Indemnitor of any obligation to the Indemnitee under this Clause      9.  It is understood that only Lonza or Micromet may claim      indemnity under this Clause 9 (on its own behalf or on behalf of its      Indemnitees), and other Indemnitees may not directly claim indemnity      hereunder. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.7 | Disclaimer of Consequential      Damages:  Subject to the second sentence of this Clause      9.7, in no event shall either Party be liable to the other Party for      incidental, indirect, special, punitive or consequential damages arising      from or related to breach of this Agreement.  The foregoing      disclaimer of damages shall not apply in the case of (a) breach of Clause      10 (Confidentiality), (b) personal injury or death, or (c) grossly      negligent or intentionally wrongful acts or  omissions. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.8 | Limitation of      Liability:  Subject to clause 9.7 and to the second      sentence of this clause 9.8, in no event shall Lonza’s liability to      Micromet for direct damages arising from or related to breach of this      Agreement exceed the total maximum aggregate sum payable under this      Agreement by Micromet.  The foregoing limitation of liability      shall not apply in the case of (a) breach of clause 10 (Confidentiality),      (b) personal injury or death, or (c) negligent or intentionally wrongful      acts or omissions. |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.9 | Insurance:  Lonza      and Micromet shall obtain and maintain during the term of this Agreement      and for [***] thereafter general liability insurance with a reputable and      solvent insurance provider in the amount of [***] per event or linked      events.  Such general liability insurance shall insure against      all mandatory liability including liability for personal injury, physical      injury and property damage.  The Parties shall provide each      other with written proof of the existence of such insurance upon      request. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.10 | [***]:  In order to      execute this Agreement, Micromet has required Lonza to enter into the      [***].  Micromet acknowledges and agrees that Lonza has no      liability to Micromet under this Agreement or otherwise, should any action      or step be taken by [***] and/or Lonza in compliance with the      [***]. |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10. | Confidentiality |
|-----|-----------------|

| 10.1 | Micromet      acknowledges that Lonza Confidential Information, and Lonza acknowledges      that Micromet Confidential Information (jointly the "Confidential      Information") with which they are supplied by the other pursuant to      the Agreement are supplied, subject to Clause 10.5, in circumstances      imparting an obligation of confidence and each agrees to keep such      Confidential Information secret and confidential and to respect the      other's proprietary rights therein and not at any time for any reason      whatsoever to disclose or permit such Confidential Information to be      disclosed to any Third Party save as expressly provided      herein. |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

| 10.2 | Micromet      and Lonza shall each procure that all their respective employees,      consultants, contractors and persons for whom it is responsible having      access to Lonza Confidential Information or Micromet Confidential      Information shall be subject to the same obligations of confidence as the      principals pursuant to Clauses 10.1 and 10.3 and shall be bound by secrecy      agreements in support of suchobligations. |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.3 | Lonza      and Micromet each undertake not to disclose or permit to be disclosed to      any Third Party other than to those of its officers, employees, agents,      consultants, licensees and financial investors that have a need to know      the Confidential Information of the disclosing Party for purposes of this      Agreement, provided      that such disclosure will be made under a confidentiality      non-disclosure agreement comprising of terms at least as stringent as the      confidentiality provisions under this Clause      10.  [***]. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.4 | Notwithstanding      Clause 10.3, Lonza and Micromet each undertake not to otherwise make use      of or permit to be made use of the Confidential Information of the other      Party or except to the extent that the same is required to be disclosed      pursuant to subpoena, court order, judicial process or otherwise by law,      provided that the      receiving Party provides prompt notice to the disclosing Party of such      requirement in order to give the disclosing Party an opportunity to timely      seek a protective order or other appropriate judicial      relief.  In the event the disclosing Party is unable to obtain a      protective order or other appropriate judicial relief, the receiving Party      shall disclose only that portion of the disclosing Party’s Confidential      Information which is legally required to be disclosed, and ensure that all      such Confidential Information of the disclosing Party shall be redacted to      the fullest extent permitted by law prior to such disclosure and that the      disclosing Party shall be given an opportunity to review the Confidential      Information prior to itsdisclosure. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.5 | The      obligations of confidence referred to in this Clause 10 shall not extend      to any information for which the receiving Party can prove by written      evidence that: |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a) | it      was or became generally available to the public otherwise than by reason      of a breach by the receiving Party of the provisions of this Clause      10; |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (b) | it      was known to the receiving Party and is at its free disposal prior to its      receipt from the disclosing Party; |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------|

|   | (c) | it      was subsequently disclosed to the receiving Party without being made      subject to an obligation of confidence by a Third  Party; |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------------------|

|   | (d) | Lonza      or Micromet are required to disclose under any statutory, regulatory or      similar legislative requirement, subject to the imposition of obligations      of secrecy wherever possible in that relation;  or |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (e) | it      was developed by any servant or agent of the receiving Party without      access to or use or knowledge of the information by the disclosing      Party. |
|--------|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.6 | The      Parties acknowledges that: |
|------|-------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

|   | (a) | without      prejudice to any other rights and remedies that the Parties may have, the      Parties agree that the Lonza Confidential Information and Micromet      Confidential Information is valuable and that damages may not be an      adequate remedy for any breach of the provisions of this Clause      10.  The Parties agree that the relevant Party will be entitled      without proof of special damage to seek the remedies of an injunction and      other equitable relief for any actual or threatened breach by the other      Party; |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (b) | save      as provided herein Lonza shall not at any time have any right, title,      licence or interest in or to the Micromet Technology or any other      Intellectual Property vested in Micromet or to which Micromet is entitled;      and |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (c) | save      as provided herein Micromet shall not at any time have any right, title,      licence or interest in or to Lonza Confidential Information, the Lonza      Technology or any other Intellectual Property relating to the Process      which are vested in Lonza or to which Lonza is otherwise      entitled. |
|--------|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.7 | All      Confidential Information is and shall remain the sole and exclusive      property of the disclosing Party.  The receiving Party agrees      that upon termination of this Agreement and subject to Micromet's right to      retain certain Confidential Information under the Technology Transfer and      License Agreement, within [***] thereafter, the receiving Party      shall:  (a) cease any use of the Confidential Information,      including any [***], and all copies of the foregoing or any portion      thereof, in whatever form or medium stored, and (b) transfer all      Confidential Information of the disclosing Party, including all documents,      samples, summaries, extracts, records or other materials that contain any      Confidential Information, in whatever form or medium stored, to the      disclosing Party or its designee, and such designee shall be subject to      legally binding nondisclosure and use restrictions that are at least as      restrictive as the terms of this Agreement, and (c) upon completion of      such transfer, certify in writing that such transfer is      complete. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 11. | Option      for [***] |
|-----|-----------------------|

| 11.1 | Lonza      hereby grants to Micromet an option to conclude a [***] for the      [***].  The terms and conditions of such [***] shall be      negotiated in good faith and based on the conditions provided in Schedule      13.  On a regular basis during the term of this      Agreement, Lonza will inform Micromet about the lead times for [***] and      the Parties will agree on any reasonable updates to Schedule 13, such      first update to be agreed after establishment of the Process at      Lonza. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 11.2 | Due      to the need of [***], Micromet will [***].  In the event that      such [***] is not concluded before regulatory approval for the Product is      granted, Micromet's option under this Clause 11 will    expire. |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 12. | Termination      of the Agreement, Termination of Certain Works and Services or      Slots |
|-----|--------------------------------------------------------------------------------------------|

| 12.1 | This      Agreement shall commence on the Effective Date and shall expire upon      completion of the Works and Services, unless earlier terminated in      accordance with this Clause 12. |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

| 12.2 | If      it becomes apparent to either Lonza or Micromet at any stage in the      provision of the Works and Services that it will not be possible to      complete the Works and Services for scientific or technical reasons, such      issue shall be discussed in the Steering Committee and a [***] period      shall be allowed for good faith discussion and attempts to resolve such      problems or to agree on a mutual termination of this Agreement. If such      problems are not resolved within such period, Micromet shall be entitled      to terminate the Agreement forthwith by notice in writing and with      immediate effect.  Furthermore, Micromet may in its sole      discretion terminate this Agreement in whole or terminate certain Works      and Services or production slots of the Project Plan at any time for any      reason by giving not less than [***] notice in writing to      Lonza.  In the event of any such termination outlined above,      Micromet shall pay to Lonza a termination sum calculated by reference to      all the Works and Services performed by Lonza prior to such termination      (including a pro rata proportion of the Price for any stage of the Works      and Services which is in process at the date of termination) and all      expenses reasonably incurred by Lonza in giving effect to such      termination, including the costs of terminating any commitments entered      into under the Agreement, provided, however, that      Lonza will make all reasonable efforts to use any materials and services      intended for Micromet for other purposes.  The termination sum      shall not exceed the unpaid Price for the stage in process and any prior      stages and no re-imbursement to Lonza is owed by Micromet in the event      notice to terminate Works and Services pursuant to this Clause 12.2 is      issued to Lonza more than [***] before Lonza's then estimated start date      for any stage. |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 12.3 | In      the event of termination pursuant to Clause 12.2 and subject to Clauses      12.5, 12.6 and 12.7 Micromet shall pay Lonza a termination sum regarding      terminated production slots calculated in accordance with the principles      of Clause 12.2 above plus: |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a) | in      the event notice to terminate Works and Services pursuant to this Clause      12.3 is issued to Lonza [***] or less before Lonza’s then estimated start      date for any stage of those Works and Services which include activities in      Lonza’s cGMP fermentation and/or purification facilities (i.e., the cGMP      Batches), or is issued to Lonza at any time during any such stage,      Micromet shall pay Lonza a sum equal to [***] [***], which payment to      Lonza shall become due on the date of termination of such Works and      Services; or |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (b) | in      the event notice to terminate Works and Services pursuant to this Clause      12.3 is issued to Lonza more than [***] but not more than [***] before      Lonza’s then estimated start date for any stage of those Works and      Services which include activities in Lonza’s cGMP fermentation and/or      purification facilities (i.e. the cGMP Batches), Micromet shall pay Lonza      a sum equal to [***] [***]; which payment to Lonza shall become due on the      date of termination of such Works and Services;  or |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (c) | in      the event notice to terminate Works and Services pursuant to this Clause      12.3 is issued to Lonza more than [***] but not more than [***] months      before Lonza’s then estimated start date for any stage of those Works and      Services which include activities in Lonza’s cGMP fermentation and/or      purification facilities (i.e. the cGMP Batches), Micromet shall pay Lonza      a sum equal to [***] [***]; which payment to Lonza shall become due on the      date of termination of such Works andServices. |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | The      price of the [***] shall not include the [***].  Any [***]      ordered at the time of termination which cannot be used by Lonza for other      purposes will be paid by Micromet and Micromet may request transfer of      such [***] to Micromet. |
|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

|   | No      re-imbursement to Lonza is owed by Micromet in the event notice to      terminate Works and Services pursuant to this Clause 12.3 is issued to      Lonza more than [***] months before Lonza's then estimated start date for      any Batch.  Furthermore and for the avoidance of doubt, no      re-imbursement to Lonza is owed by Micromet  [***] |
|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 12.4 | Lonza      shall use commercially reasonable efforts to otherwise      [***].  The obligation to make payment under Clause12.3 shall be      reduced (retrospectively, and hence Lonza shall make an appropriate refund      to Micromet) to the extent that Lonza mitigates its loss in this regard      (and Lonza shall promptly notify Micromet of any such      mitigation).  This provision shall not entitle Micromet to be      refunded an amount greater than that paid by Micromet to Lonza pursuant to      this Clause 12 and Lonza shall be entitled to deduct from the amount due      to be refunded to Micromet its reasonable personnel and associated costs      in attempting to mitigate its loss. |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 12.5 | For      the avoidance of doubt activities relating to cGMP fermentation shall be      deemed to commence with the date of removal of the vial of cells from      frozen storage for the performance of the  fermentation. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 12.6 | The      Parties may each terminate the Agreement forthwith by notice in writing to      the other Party if the other commits a material breach of the Agreement      (which shall include a breach of the warranties set out in Clause 9 above)      which in the case of a breach capable of remedy is not remedied within      [***] in the event of a breach of payment obligations, and within [***] in      the event of any other breach, of the receipt by the other of notice      identifying the breach and requiring itsremedy. |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 12.7 | Micromet      may terminate this Agreement forthwith by notice in writing to Lonza upon      the occurrence of any of the followingevents: |
|------|--------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a) | [***]; |
|--------|-----|--------|

|   | (b) | [***]; |
|--------|-----|--------|

|   | (c) | [***]. |
|--------|-----|--------|

| 12.8 | Upon      the termination of this Agreement for whatever  reason: |
|------|-------------------------------------------------------------------|

|   | (a) | Lonza      shall promptly return to Micromet all Micromet Know How and shall dispose      of or return to Micromet the Micromet Materials, the Micromet Cell Line      and the Micromet Process and any materials therefrom, as directed by      Micromet; |
|--------|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (b) | Micromet      shall promptly return to Lonza all Lonza Confidential Information it has      received from Lonza; |
|--------|-----|------------------------------------------------------------------------------------------------------------------|

|   | (c) | Lonza      shall summarize all Works and Services performed up to the termination of      the Agreement and provide such summary documents to    Micromet; |
|--------|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (d) | subject      to Clause 14 below, Micromet shall not thereafter use or exploit the Lonza      Technology in any way whatsoever;and |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

|   | (e) | Lonza      and Micromet shall do all such acts and things and shall sign and execute      all such deeds and documents as the other may reasonably require to      evidence compliance with this Clause12.8. |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 12.9 | Termination      of this Agreement for whatever reason shall not affect the accrued rights      of either Lonza or Micromet arising under or out of this Agreement and all      provisions which are expressed to survive the Agreement shall remain in      full force and effect. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 13. | [***] |
|-----|-------|

|   | (a) | engage      in, continue in or carry on [***] as the [***] or [***], including [***]      which is so engaged; |
|--------|-----|----------------------------------------------------------------------------------------------------------------|

|   | (b) | consult      with, advise or assist in any way, whether or not for consideration, any      corporation or other business organization [***] as the [***] or      [***]; |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (c) | engage      in any practice the purpose of which is to evade the provisions of this      [***]; |
|--------|-----|-------------------------------------------------------------------------------------------------|

|   | provided, however, that      the foregoing prohibition does not extend to [***] of the [***] of the      [***]. |
|--------|-----------------------------------------------------------------------------------------------------------------|

| 14. | Technology      Transfer and License |
|-----|--------------------------------------|

|   | At      any time during the course of this Agreement [***], Micromet has the      option to conclude the Technology Transfer and License Agreement between      Micromet and Lonza attached hereto as Schedule 14, in      order to allow Micromet (or a [***] designated by Micromet) to replicate      the Process (as it exists at the date of such request) in the manufacture      of the Product in order to either establish a second source for supply or      to transfer manufacturing to a Third Party, provided, however, that      [***]).  Following exercise of the option and provided [***] of      Lonza have been used for the manufacture of Product, Lonza shall supply to      Micromet such information and assist Micromet regarding access to [***],      as is agreed therein. |
|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 15. | Force      Majeure |
|-----|--------------------|

| 15.1 | If      Lonza is prevented or delayed in the performance of any of its obligations      under the Agreement by Force Majeure and shall give written notice thereof      to Micromet specifying the matters constituting Force Majeure together      with such evidence as Lonza reasonably can give and specifying the period      for which it is estimated that such prevention or delay will continue,      Lonza shall be excused from the performance or the punctual performance of      such obligations as the case may be from the date of such notice for so      long as such cause of prevention or delay shall  continue. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 15.2 | The      expression "Force      Majeure" shall be deemed to include any cause affecting the      performance by Lonza of the Agreement arising from or attributable to      acts, events, acts of God, omissions or accidents beyond the reasonable      control of Lonza. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

| 16. | Governing      Law, Jurisdiction andEnforceability |
|-----|----------------------------------------------------|

| 16.1 | The      construction, validity and performance of the Agreement shall be governed      by the laws of Switzerland. |
|------|---------------------------------------------------------------------------------------------------------------------|

| 16.2 | No      failure or delay on the part of either Lonza or Micromet to exercise or      enforce any rights conferred on it by the Agreement shall be construed or      operate as a waiver thereof nor shall any single or partial exercise of      any right, power or privilege or further exercise thereof operate so as to      bar the exercise or enforcement thereof at any time or times      thereafter. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 16.3 | Any      disputes relating to issues arising from this Agreement shall, in the      absence of resolution within [***] of the dispute arising, be referred to      the [***] of Micromet and Lonza, who shall discuss the matter and attempt      to resolve it by mutual consent.  The [***] of Micromet and      Lonza shall meet once face-to-face within [***] to discuss and resolve the      dispute.  If the dispute cannot be resolved within [***], either      Party may, by written notice to the other Party, invoke the mediation      procedure set out in Clause 16.4below. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 16.4 | If      a dispute arises between the Parties that the Parties cannot resolve      pursuant to Clause 16.3 above, the Parties agree to try to solve such      dispute amicably by mediation.  The Parties shall conduct a      mediation procedure according to the ICC ADR Rules of the International      Chamber of Commerce (ICC) in effect on the date of the commencement of the      mediation proceedings.  The location of the mediation      proceedings will be Basel. The number of mediators will be one      (1).  The language of the mediation proceeding will be      English.  If the dispute has not been settled pursuant to the      said rules within [***] following the filing of a request for mediation or      within such other period as the Parties may agree in writing, either Party      may submit the dispute to final and binding  arbitration. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 16.5 | Any      dispute relating to the validity, performance, construction or      interpretation of this Agreement, which cannot be resolved amicably      between the Parties, shall be submitted to arbitration in accordance with      the ICC Arbitration Rules of the International Chamber of      Commerce.  The decision of the arbitrators shall be final and      binding upon the Parties (absent manifest error on the part of the      arbitrator(s)) and enforceable in any court of competent      jurisdiction.  The location of arbitration will be      Basel.  The arbitration will be heard and determined by one (1)      arbitrator, who will be jointly selected by Lonza and      Micromet.  If, within [***] following the date upon which a      claim is received by the respondent, the Parties cannot agree on a single      arbitrator, the arbitration will be heard and determined by three (3)      arbitrators, with one arbitrator being appointed by each Party and the      third arbitrator being selected by the two Party-appointed      arbitrators.  If either Party fails to select an arbitrator, or      if the Party-appointed arbitrators cannot agree on a third arbitrator      within [***] of the respondent receiving the claim, such arbitrator will      be appointed by the International Court of Arbitration according to the      ICC Rules.  The arbitration award that is consistent with the      provisions of this Agreement that is so given will be binding upon the      Parties, accompanied by a reasoned opinion in writing (in English), and      the judgment on the award may be entered in any court having competent      jurisdiction thereof.  Each Party will bear its own costs and      expenses (including its attorney’s fees) associated with any arbitration      initiated under this section, and each Party will bear an equal share of      the arbitrators’ and administrative fees associated with any arbitration      initiated under this section.  The language of the arbitration      proceeding will be English.  Notwithstanding the provisions of      this Clause 16.5, each Party shall have the right to seek preliminary or      permanent injunctive or other equitable relief in any court of competent      jurisdiction as such Party deems necessary to preserve its rights and to      protect its interests. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

| 16.6 | Nothing      in this Clause 16 shall prevent a Party from exercising any right under      this Agreement, including the right of termination under Clause 12      above. |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 17. | Notices |
|-----|---------|

| 17.1 | Any      notice or other communication to be given under this Agreement shall be      delivered personally or sent by facsimile transmission, or if facsimile      transmission is not available, by first class pre-paid post addressed as      follows: |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (a)    | If to Lonza to:  | Lonza Sales AG                                             |
|--------|--------------------------------------|----------------------------------------------------------------------|
|   |                                 | Muenchensteinerstrasse 38                                       |
|   |                                 | CH-4402 Basel                                                   |
|   |                                 | Switzerland                                                |
|   |                                 | Facsimile: +41 61 316 8329                       |
|   |                                 | Attention: The Head of Legal Services       |
|   |                                 |                                                                 |
|   | with a copy to:       | Lonza Biologics plc                                        |
|   |                                 | 228 Bath Road                                              |
|   |                                 | Slough                                                               |
|   |                                 | Berkshire SL1 4DX                                          |
|   |                                 | England                                                              |
|   |                                 | Facsimile: +44 1753 777001                            |
|   |                                 | Attention:  The Head of Legal Services |
|   |                                 |                                                                 |
| (b)    | If to Micromet to:    | Micromet AG                                                     |
|   |                                 | Staffelseestrasse 2                                             |
|   |                                 | D-81477 Munich                                                  |
|   |                                 | Germany                                                              |
|   |                                 | Facsimile: +49-89-895 277 205                         |
|   |                                 | Attention: Head of Business Development          |
|   |                                 |                                                                 |
|   | with a copy to:       | Micromet, Inc.                                             |
|   |                                 | 6707 Democracy Boulevard                                   |
|   |                                 | Suite 505                                                       |
|   |                                 | Bethesda, MD 20817                                         |
|   |                                 | United States of America                              |
|   |                                 | Attention: General Counsel                                 |
|   |                                 | Facsimile: +1 240 752-1425                            |

| 17.2 | All      such notices or other communications shall be deemed to have been served      as follows: |
|------|----------------------------------------------------------------------------------------------------|

|   | (a) | if      delivered personally, at the time of such  delivery; |
|--------|-----|--------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

|   | (b) | if      sent by facsimile, upon receipt of the transmission confirmation slip      showing completion of thetransmission; |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------|

|   | (c) | if      sent by first class pre-paid post, ten (10) business days (Saturdays,      Sundays and Bank or other public holidays excluded) after being placed in      the post. |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 18. | Illegality |
|-----|------------|

| 18.1 | If      any provision or term of this Agreement or any part thereof shall become      or be declared illegal, invalid or unenforceable for any reason whatsoever      including but without limitation by reason of the provisions of any      legislation or other provisions having the force of law or by reason of      any decision of any Court or other body or authority having jurisdiction      over the Parties hereto or this Agreement including the EC Commission or      the European Court of Justice: |
|------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a) | such      provision shall, so far as it is illegal, invalid or unenforceable, be      given no effect by the Parties and shall be deemed not to be included in      this Agreement; |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (b) | the      other provisions of this Agreement shall be binding on the Parties as if      such provision was not included therein;and |
|--------|-----|------------------------------------------------------------------------------------------------------------------------------------|

|   | (c) | the      Parties agree to negotiate in good faith to amend such provision to the      extent possible for incorporation herein in such reasonable manner as most      closely achieves the intention of the Parties without rending such      provision invalid or unenforceable. |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 19. | Quality      Agreement |
|-----|------------------------|

|   | Simultaneously      with the execution of this Agreement, the Parties will enter into a      separate quality agreement as annexed hereto as Schedule 10      ("Quality      Agreement").  The Quality Agreement and its Exhibits      supplement this Agreement.  To the extent that inconsistencies      exist between the contents of the Quality Agreement and this Agreement,      the stipulations of this Agreement shall  prevail. |
|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 20. | Miscellaneous |
|-----|---------------|

| 20.1 | Lonza      shall be entitled to instruct one or more of its Affiliates to perform any      of Lonza’s obligations contained in this Agreement, but Lonza shall remain      fully responsible in respect of those obligations.  Subject      thereto, neither Party shall be entitled to assign, transfer, charge or in      any way make over the benefit and/or the burden of this Agreement without      the prior written consent of the other which consent shall not be      unreasonably withheld or delayed, save that either Party shall be entitled      without the prior written consent of the other Party to assign, transfer,      charge, sub-contract, deal with or in any other manner make over the      benefit and/or burden of this Agreement to a successor of that Party’s      business by reason of merger, sale or license of all or substantially all      of its assets related to this Agreement or any other form of      acquisition. |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy |  |
|---------------------|--|

| 20.2 | The      obligations of the Parties under Clauses 8 (Intellectual Property), 9      (Warranties and Indemnification), 10 (Confidentiality), and 12.8 and 12.9      (consequences of termination) and 14 (Technology Transfer and License)      shall survive the termination of this Agreement for any      reason. |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 20.3 | The      press releases that Micromet and Lonza will issue upon execution of this      Agreement are attached hereto as Schedule      15.  The text of any further press release or other      further communication to be published by or in the media concerning the      subject matter of the Agreement shall require the prior written approval      of Lonza and Micromet. |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 20.4 | The      Agreement embodies the entire understanding of Lonza and Micromet and      there are no promises, terms, conditions or obligations, oral or written,      expressed on implied, other than those contained in the      Agreement.  The terms of the Agreement shall supersede all      previous agreements (if any) which may exist or have existed between Lonza      and Micromet relating to the Works andServices. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 20.5 | The      Parties to this Agreement do not intend that any term hereof should be      enforceable by any person who is not a Party to this      Agreement. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------|

| 20.6 | No      variation of or addition to this Agreement or any part thereof shall be      effective unless in writing and signed on behalf of both      Parties.  Notwithstanding the above the Parties hereby confirm      that amendments to the Specifications shall be effective if reduced to      writing and signed by the quality and/or regulatory representative of both      Parties, which quality and/or regulatory representative shall be nominated      from time to time by each Party. |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| Schedule 1:              | Micromet      Materials including Cell Line Particulars |
|-------------------------------|---------------------------------------------------------|
| Schedule 2:              | Product      Specifications                             |
| Schedule 3:              | Prices      and Terms of Payment                        |
| Schedule 4:              | Identification      of Lonza Know How                   |
| Schedule 5:              | List      of Lonza Patent Rights                        |
| Schedule 6:              | Identification      of Micromet Know-How                |
| Schedule 7:              | List      of Micromet Patent Rights                     |
| Schedule 8 A:  | Project      Plan up to Stage 30                        |
| Schedule 8 B:       | Project      Plan for pre-LA (as of Stage 31)           |
| Schedule 9:              | [***]      Agreement                                    |
| Schedule 10:             | Quality      Agreement                                  |
| Schedule 11:             | Testing      of Product                                 |
| Schedule 12:             | Territories                                             |
| Schedule 13:             | Terms      and Conditions for [***]                     |
| Schedule 14:             | Technology      and License Agreement                   |
| Schedule 15:             | Micromet      Press Release and Lonza PressRelease      |

----

| Execution      Copy |  |
|---------------------|--|

| Micromet      AG |   | Lonza      Sales AG |
|------------------|--------|---------------------|
|             |   |                |

| Signature: | /s/ Jens Hennecke |   | Signature: | /s/ UnaHultry |
|------------|-------------------|--------|------------|---------------|

| Printed      Name: | Jens Hennecke |   | Printed      Name: | UnaHultry |
|--------------------|---------------|--------|--------------------|-----------|

| Title: | SVP Business Development |   | Title: | Authorized Signatory |
|--------|--------------------------|--------|--------|----------------------|
|   |                     |   |   |                 |

| Signature: | /s/ Patrick Baeuerle |   | Signature: | /s/ GerryKennedy |
|------------|----------------------|--------|------------|------------------|

| Printed Name: | Patrick Baeuerle |   | Printed      Name: | GerryKennedy |
|--------------------|------------------|--------|--------------------|--------------|

| Title: | SVP, Chief Scientific    Officer |   | Title: | Authorized  Signatory |
|--------|----------------------------------|--------|--------|-----------------------|

----

----

----

----

----

----

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| ApplicationNumber |   | ApplicationFiling Date |   |   | Country |   |   | Title of Application |   |   | Status |   |   | Patent Number |   |
|-------------------|--------|-----------------------------|--------|--------|---------|--------|--------|--------------------------------|--------|--------|--------|--------|--------|--------------------|--------|
|              |   |                        |   |   |    |   |   |                           |   |   |   |   |   |               |   |   |   |   |   |   |

----

----

----

----

----

----

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| 1. | LONZA SALES AG, of      Muenchensteinerstrasse 38, CH-4002, Basel, Switzerland (hereinafter      referred to as "Lonza")    and |
|----|---------------------------------------------------------------------------------------------------------------------------------|

| 2. | MICROMET AG, of      Staffelstrasse 2, D-81477, Munich, Germany (hereinafter referred to as      "Micromet") |
|----|--------------------------------------------------------------------------------------------------------------|

| A | Lonza      and Micromet have entered into a Development and Supply Agreement pursuant      to which Lonza agreed to provide Micromet with development, manufacturing      and supply services ("Works and Services") for      Micromet's Intermediate Biological (Investigational) Medicinal Product      (IB(I)MP) MT103 (also known as Blinatumomab) for use as proprietary      investigational medicinal product (the "Product"). |
|---|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| B. | The      Parties now wish to further define the pharmaceutical roles and      responsibilities of each Party for the Manufacture, testing and Release of      Product with respect to relevant current Good Manufacturing Practices      ("cGMP") and      Applicable Laws. Nothing in this Quality Agreement shall limit a Party’s      obligation to comply with cGMP and Applicable Laws (as defined below) on      the occasion that Lonza Manufactures Product for Micromet for further      manufacturing use in the preparation of human drug products for clinical      trial supply. |
|----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| C | This      Quality Agreement takes the form of a detailed checklist of the activities      associated with the production, analysis, release, and distribution of      Product. Responsibility for each activity is assigned to either Lonza      and/or Micromet in the appropriate box in the delegation responsibility      checklist that follows. To facilitate routine communications between the      Parties, a list of key contacts is provided in Annex 1. For each      responsibility listed, the respective Party is required to put into effect      all applicable procedures and to take all necessary actions to execute      that responsibility in accordance with cGMP and Applicable      Laws. |
|---|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| D. | The      Parties wish that Lonza, having particular expertise in the activities      contained in this Quality Agreement (as defined below), may perform the      activities and obligations set forth in this Quality      Agreement. |
|----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| 1      | .      | Preface      / Overall Responsibilities                                               | 4                                                      |
|--------|--------|---------------------------------------------------------------------------------------|--------------------------------------------------------|
| 2      | .      | Definitions      and Interpretation                                                   | 5                                                      |
| 3      | .      | Facilities      / Materials Controls                                                  | 8                                                      |
|   |   | 3.1                                                                                   | Organization      and Key Personnel                    | 8 |
|   |   | 3.2                                                                                   | Buildings,      Facilities, Utilities and Equipment    | 9 |
|   |   | 3.3                                                                                   | Raw      Materials Controls                            | 10 |
| 4      | .      | Process      Controls                                                                 | 11                                                     |
|   |   | 4.1                                                                                   | Cell      Banks                                        | 11 |
|   |   | 4.2                                                                                   | Product      Specification                             | 11 |
|   |   | 4.3                                                                                   | Production,      Process Handling and Process Control  | 11 |
|   |   | 4.4                                                                                   | Product      Storage, Labeling, Packaging and Shipment | 13 |
| 5      | .      | Quality      Control Laboratories                                                     | 13                                                     |
|   |   | 5.1                                                                                   | QC      Laboratory Controls                            | 13 |
| 6      | .      | Quality      Assurance / Quality Management Systems                                   | 15                                                     |
|   |   | 6.1                                                                                   | Complaints,      Recalls and Adverse Events            | 15 |
|   |   | 6.2                                                                                   | Batch      Review and Product Disposition              | 16 |
|   |   | 6.3                                                                                   | Records      Retention                                 | 16 |
|   |   | 6.4                                                                                   | Deviations      / Investigation Reports                | 16 |
|   |   | 6.5                                                                                   | Change      Control Procedures                         | 17 |
| 7      | .      | Regulatory      Authorizations and Inspections                                        | 18                                                     |
|   |   | 7.1                                                                                   | Regulatory      Agency Inspections                     | 18 |
|   |   | 7.2                                                                                   | Regulatory      Authorizations / Submissions           | 18 |
| 8      | .      | Micromet      Oversight                                                               | 19                                                     |
|   |   | 8.1                                                                                   | Audit      Allowance                                   | 19 |
|   |   | 8.2                                                                                   | Periodic      Review of Quality Agreement              | 20 |
| 9      | .      | Term                                                                                  |                                                   | 21 |
| 10     | .      | Miscellaneous                                                                         | 22                                                     |
|   |   | Annex      1 - Key Contacts                                                           | 23                                                     |
|   |   | Annex      2 - Multi Site Responsibilities Matrix                                     | 24                                                     |
|   |   | Annex      3 - Additional Considerations for IB(I)MP Intended for Commercial      Use | 25                                                     |
|   |   | Annex      4 - Information to be provided to Micromet                                 | 26                                                     |

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| 1.1 | This      Quality Agreement outlines the responsibilities of Micromet and Lonza with      respect to the quality assurance of Product Manufactured by Lonza for      Micromet under the terms of the Development and Supply Agreement and in      accordance with cGMP and ApplicableLaws. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.2 | Micromet      acknowledges that certain activities and obligations under the Quality      Agreement may be performed by Lonza’s Affiliates having expertise in the      relevant areas, provided that (i) Lonza shall remain responsible to      Micromet for the acts and omissions of their Affiliates; and (ii) Micromet      is at any time informed which of Lonza's Affiliates is in charge of that      certain activities and obligations. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.3 | The      following delegation responsibility checklist describes generic quality      activities that are to be performed by both Parties for Product used by      Micromet for further manufacturing use in the preparation of human drug      products for clinical trial supply / in market supply.  The      specific Works and Services to be provided by Lonza are set out in the      Development and Supply Agreement (and any amendments to the Development      and Supply Agreement) on Price and other terms accepted by both      Parties. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.4 | Lonza      is responsible for ensuring that the quality requirements for Product are      as specified in the approved Product Specification and that Product is      Manufactured in accordance with cGMP and all Applicable    Laws. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.5 | Lonza      is responsible for final review, approval and QP certification of the      Product for further processing. |
|-----|-----------------------------------------------------------------------------------------------------------------------|

| 1.6 | LONZA      is responsible for analytical testing of the Product and the further      processed Drug Product. |
|-----|--------------------------------------------------------------------------------------------------------------|

| 1.7 | Micromet      or its designee is responsible for shipping and the final review, approval      and Release of the final Drug Product for use in clinical trial      supply. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

|   | Applicable      Laws | means      all applicable provisions of all statutes, laws, rules, regulations,      administrative codes, permits and licenses from regulatory authorities or      agencies applicable to the Manufacture of the  Product; |
|--------|----------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Batch | means      the total Product (Drug Substance) obtained from the fermentation and      associated purification using the Process and carried out in accordance      with cGMP and Applicable Laws; |
|--------|-------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Batch      Records | means      the completed documentation associated with the manufactured Product on      each Batch for official and cGMP compliant documentation      purposes; |
|--------|--------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Certification | means      a certification of any Batch by a Qualified Person for further processing      confirming that the Batch is manufactured in accordance with the relevant      requirements for human use (as defined in Directive 2001/83/EC for      medicinal products for human use), commonly known as “QP batch      release”; |
|--------|---------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | CofA | means      Certificate of Analysis; |
|--------|------|-------------------------------------|

|   | CofC | means      Certificate of Compliance; |
|--------|------|---------------------------------------|

|   | cGMP | means      current Good Manufacturing Practice and general biologics products      standards as promulgated under the European Commission Directives      91/356/EEC, as amended by Directive 2003/94/EC, and 91/412EEC      respectively; the International Committee for Harmonisation (ICH) Q7      Guideline on Good Manufacturing Practice for Active Pharmaceutical      Ingredients; the U.S. Federal Food, Drug and Cosmetic Act found in Title      21 of the U.S. Code of Federal Regulations (CFR), including but not      limited to Parts 210, 211 and Parts 11, 310 et seq., 600 to 610, the      European Commission Guidelines of Good Manufacturing Practices for      Medicinal Products as promulgated under European Directive 2003/94/EC      (Eudralex – Volume IV) and the respective Japanese directives and      guidelines by the Japanese authorities, as applicable. Lonza meets EU GMP      requirements as defined in Eudralex - Volume IV Good Manufacturing      Guidelines by the European Commission for medicinal products for human and      veterinary use (EU-GMP Guidelines); |
|--------|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Development      andSupply      Agreement | means the      Development and Supply Agreement to which this      Quality Agreement is attached as Schedule      10; |
|--------|-------------------------------------------|-----------------------------------------------------------------------------------------------------------------------|

|   | Drug    Product | Product      or a combination of Product with other substances being in its final      container suitable for administration to human beings (bulk unlabeled and      final product labeled). |
|--------|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

|  | Drug Product      Specification | means      the specification for Drug Product, set forth under Sections B and C of      Schedule 2 of the Development and Supply Agreement, and any amendments to      any of the foregoing specifications regarding the Drug Product as agreed      upon by the Parties from time totime; |
|--|---------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Facility/      Facilities | means      the facilities of Lonza where the Product is Manufactured in compliance      with cGMP and Applicable Laws. Facilities of sub-contractors of Lonza      shall only be deemed Facilities under this Quality Agreement upon prior      written approval of Micromet; |
|--------|---------------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | FDA | means      U.S. Food and Drug Administration; |
|--------|-----|-----------------------------------------------|

|   | FEFO | means      First Expired First Out; |
|--------|------|-------------------------------------|

|   | FIFO | means      First In First Out; |
|--------|------|--------------------------------|

|   | ICH | means      International Conference onHarmonization; |
|--------|-----|------------------------------------------------------|

|   | IB(I)MP | means      Intermediate Biological (Investigational) Medicinal Product also known as      Drug Substance; |
|--------|---------|-----------------------------------------------------------------------------------------------------------|

|  | Manufacture /      Manufacturing | means      and includes all operations of the Process used by Lonza for the      production of the Product in accordance with the Product Specification and      cGMP, i.e., receipt of materials, production, packaging, repackaging,      labeling, relabeling, quality control, quality assurance, Release, storage      and distribution of the Product; |
|--|----------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Product | means      IB(I)MP of MT103 Manufactured under the Development and Supply Agreement      in accordance with the Product Specifications, cGMP and Applicable      Laws; |
|--------|---------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Product      Specification | means      the receiving, in-process and finished Product specification for Drug      Substance, set forth in Section A of Schedule 2 of the Development and      Supply Agreement applicable to the Product, as amended in accordance with      the Development and Supply Agreement and this Quality Agreement, and any      amendments to any of the foregoing specifications regarding the Product as      agreed upon by the Parties from time totime; |
|--------|----------------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Qualified Person/      QP | means      a person qualified pursuant to Applicable Laws confirming that the Batch      is in accordance with the relevant requirements (as defined in Directive      2001/83/EC for medicinal products for human  use); |
|--------|---------------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Quality      Agreement | means      this Quality Agreement which is attached to the Development and Supply      Agreement as Schedule 10; |
|--------|------------------------|------------------------------------------------------------------------------------------------------------------|

|   | Raw      Materials | means      all raw materials, supplies, components and packaging necessary to      Manufacture the Product in accordance with the Product Specification, but      not including the Product |
|--------|--------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Reprocessing | means      the process by which a lot or portion of a lot is purified through repeat      of established and approved Manufacturing steps to produce Product that      meets appropriate standards, specifications and any other relevant control      limit criteria; |
|--------|--------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

|   | SOP(s) | means      the standard operating procedures in effect at Lonza which are applicable      to the Manufacture of the Product and which comply with cGMP and      applicable Laws; |
|--------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | TSE/BSE | means      Transmissible Spongiform Encephalopathy / Bovine Spongiform      Encephalopathy. |
|--------|---------|---------------------------------------------------------------------------------------------|

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| 3.1         Organization      and Key Personnel                                                                                                                                                                                                                                                                    |
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Lonza      Responsibility                                                                                                                                                                                                                                                                                                                                       |   | Micromet      Responsibility |
| ·          Will maintain a quality unit that is independent of the production      unit and has the responsibility and authority to approve or reject      components, Raw Materials/ [***], bulk packaging materials, Product, SOPs,      master Batch Records, deviation/investigations, and executed production      Batch Records. |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                            |   |   |
| ·          Will provide and document initial and on-going cGMP and process      specific technical training of employees involved in GMP      operations.                                                                                                                                                                              |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                            |   |   |
| ·          Will ensure that the use of consultants is supported by documented      verification that the consultant(s) has(have) the sufficient education,      training, experience, or any combination thereof, to advise on the subject      for which they are retained.                                                           |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                            |   |   |
| ·          Ensure and allocate adequate number of personnel have appropriate      training, skills, knowledge and experience to perform and supervise the      Manufacture and testing of the Product and the Drug Product in accordance      to cGMP and Applicable Laws.                                                             |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                            |   |   |
| ·          Will ensure that responsibilities and procedures applicable to the      quality unit are documented in writing and consistently      followed.                                                                                                                                                                              |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                            |   |   |
| ·          Will conduct internal audits of all relevant activities to ensure      compliance with cGMP and applicable SOPs. Audit findings and corrective      actions will be documented, brought to the attention of Lonza’s Facility      management, and resolved in a timely and effective manner.                          |   | N/A |

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| 3.2         Buildings,      Facilities, Utilities and Equipment                                                                                                                                                                                                                                                                          |
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Lonza      Responsibility                                                                                                                                                                                                                                                                                                                                                             |   | Micromet      Responsibility |
| ·          Ensure Facilities, premises, environment, utilities, equipment and      computerised systems are properly designed, validated and maintained in      accordance with cGMP and Applicable Laws.                                                                                                                                                    |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Will be responsible for ensuring that any Facility owned and      operated by a sub-contractor who performs GMP relevant work operates in      compliance with cGMP and Applicable Laws. Will inform Micromet in advance      of its intent to sub-contract. Will sub-contract only upon written      approval from Micromet for sub-contracting. |   | ·          Approval of Facilities. |
|                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Provide a list, upon request, to Micromet of any sub-contractors      used to perform GMP operations, or GMP support operations.                                                                                                                                                                                                                  |   | ·          Review list. |
|                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Maintain controlled access to Facilities.                                                                                                                                                                                                                                                                                                         |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Via change control will notify Micromet as soon as reasonably      practicable of any known changes in ownership of sub-contractors used by      Lonza (See Change      Control Section under Section 6.5 for further    details).                                                                                                                |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Ensures appropriate separation and controls are in place for      operation of multi-product Facilities. An example of a multi site      responsibilities matrix is attached hereto as Annex 2.                                                                                                                                                   |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Review data provided by Micromet.                                                                                                                                                                                                                                                                                                                 |   | ·          Upon request, will provide Lonza with Product data/samples required      to conduct cleaning studies. |
|                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Label and store any Product dedicated equipment to adequately      prevent unintended use for other products.                                                                                                                                                                                                                                     |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Maintain an environmental water and clean steam monitoring program      to ensure compliance with environmental monitoring regulations and      SOPs.                                                                                                                                                                                             |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Will qualify, maintain and calibrate equipment and utility services      associated with Manufacturing the Product in accordance with cGMP,      Applicable Laws, and SOPs.                                                                                                                                                                       |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Will ensure, via validation or verification, that cleaning      processes carried out on Product contact surfaces between batches of      different products and Raw Materials/[***] are adequate to prevent      contamination.                                                                                                                  |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Will maintain complete and accurate cleaning and use logs of      equipment used for the Manufacture of Product                                                                                                                                                                                                                                   |   | N/A |

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| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| 3.3        Raw      Materials Controls                                                                                                                                                                                                                                                                                                                                                     |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Lonza      Responsibility                                                                                                                                                                                                                                                                                                                                                                                                          |   | Micromet      Responsibility |
| ·          Source, test and release Raw Materials and/or primary packaging of      appropriate quality for processing of Product.                                                                                                                                                                                                                                                                         |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                                                               |   |   |
| ·          Ensure that all animal derived Raw Materials used for Product are      appropriately tested in line with cGMP and ApplicableLaws.                                                                                                                                                                                                                                                              |   | ·          As applicable, provide information to Lonza on any known animal      derived Raw Materials requested for use in the    Manufacturing. |
|                                                                                                                                                                                                                                                                                                                                                                                                                               |   |   |
| ·          Assess and approve Suppliers of Raw Materials and components in      accordance with the relevant Lonza SOPs.                                                                                                                                                                                                                                                                                  |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                                                               |   |   |
| ·          Retain representative samples of critical Raw Materials, as      appropriate and in accordance with the relevant SOP(s) and cGMP for      retention samples; ·          Store, under appropriate conditions, a quantity sufficient to      perform at least two (2) full analyses, according to the relevant      SOP.                                      |   | N/A |
| ·          Establish and maintain specifications for GMP materials as per      SOPs.                                                                                                                                                                                                                                                                                                                      |   | ·          As applicable, specify any special requirements for specifications      of GMP materials used in the process. |
|                                                                                                                                                                                                                                                                                                                                                                                                                               |   |   |
| ·          Utilize either FEFO or FIFO strategy for consumption of GMP      materials.                                                                                                                                                                                                                                                                                                                    |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                                                               |   |   |
| ·          Use Product bulk packaging and labelling information specified by      Micromet; ·          If not specified by Micromet, utilize Lonza generic bulk packaging      and labelling configurations as per SOP(s).                                                                                                                                                  |   | ·          Approve Product bulk packaging and information on the      label |
|                                                                                                                                                                                                                                                                                                                                                                                                                               |   |   |
| ·          Will be responsible for maintenance of specifications of the Raw      Materials / [***].                                                                                                                                                                                                                                                                                                       |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                                                               |   |   |
| N/A                                                                                                                                                                                                                                                                                                                                                                                                                                |   | ·          Will approve all sources of Raw Materials/ [***] and other      materials used in the process. |
|                                                                                                                                                                                                                                                                                                                                                                                                                               |   |   |
| ·          Will be responsible for procurement, storage, sampling, testing,      release, assigning expiration or re-test dating, and maintaining records      for each delivery of Raw Materials/[***].                                                                                                                                                                                                  |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                                                               |   |   |
| ·          Will maintain a program to audit (if required) and qualify      suppliers of  critical Raw Materials/ [***] used in the      Manufacturing of   Product to ensure full compliance with      cGMP and Applicable Laws and to verify the status of Raw Materials/[***]      of animal origin with respect to Transmissible Spongiform Encephalopathy      (TSE) issues. |   | N/A |

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| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| Lonza      Responsibility                                                                                                                                                                                      |   | Micromet      Responsibility                                                                                                                                                      |
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| ·          Review and approve characterisation data and store working stock of      Cell Banks in accordance with the Development and Supply Agreement      and Applicable Laws. |   | ·          Supply Cell Banks and characterisationdata.                                                                                              |
|                                                                                                                                                                                                           |   |                                                                                                                                                                              |
| ·          Discuss any unexpected result with Micromet and agree action(s) to      be taken.                                                                                          |   | ·          If Cell Banks are tested by any other organisation other than      Lonza, any unexpected results must be reported to Lonza within      [***]. |
|                                                                                                                                                                                                           |   |                                                                                                                                                                              |
| ·          Review data.                                                                                                                                                               |   | ·          Provide shipping validation for shipping container used to ship      Cell Banks.                                                              |
|                                                                                                                                                                                                           |   |                                                                                                                                                                              |
| ·          Will store the [***] (as well as the [***] [***] after generation      through Lonza) [***].                                                                               |   | N/A                                                                                                                                                                               |
|                                                                                                                                                                                                           |   |                                                                                                                                                                              |
| ·          Prepare, characterize and store [***] per SOPs.                                                                                                                            |   | N/A                                                                                                                                                                               |

| 4.2        Product      Specification                                                                                                                                                                                                                                                       |
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Lonza      Responsibility                                                                                                                                                                                                                                                                                                           |   | Micromet      Responsibility |
| ·          Jointly review, approve  and issue the following      Product Specification(s) as required per Development and Supply      Agreement: ·      IB(I)MP ·      Drug      Product.    |   | ·          Jointly review and approve, via the Micromet approval form, the      following Product Specification(s) as required per Development and      Supply Agreement: ·      IB(I)MP ·      Drug      Product. ·          Complete review, resolution of any questions and approval of      Product Specification within [***] from date of receipt or within another      timeline that has been mutually agreed by Micromet and    Lonza. |
|                                                                                                                                                                                                                                                                                                                                |   |   |
| ·          In accordance with Lonza Quality Standard GROUP-2500, jointly      review, approve and issue the master certification documents (e.g. CofA,      CofC...etc), as required per Micromet.                                                                                                         |   | ·          Review and approve, via the Micromet approval form, the required      master certification documents, as applicable; ·          Complete review, resolution of any questions and approval of master      product certification documents within [***] from date of receipt or      within another timeline that has been mutually agreed by Micromet and      Lonza. |

| 4.3        Production,      Process Handling and Process Control                                                                                                                                                |
|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Lonza      Responsibility                                                                                                                                                                                                                               |   | Micromet      Responsibility |
| ·          Prepare, approve and maintain process documents relating to      facility, equipment and test methods.                                                                                                              |   | N/A |
|                                                                                                                                                                                                                                                    |   |   |
| ·          Will develop, optimize and scale up Manufacturing processes in      compliance with the requirements set forth in the guideline ICH Q8,R1      (Pharmaceutical Development) and make use of Quality by      Design. |   | N/A |

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| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| ·          Will perform quality risk management as Part of development in      compliance with the requirements set forth in chapter II.3 of the      guideline ICH Q9 (Pharmaceutical Development) and therefore      will: ·          assess the critical attributes of Raw Materials; ·          identify critical process parameters and establish manufacturing      controls. |   | N/A                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| ·          Will compile a development report in a form suitable for      incorporation into regulatory submissions (i.e. IMPD/IND).                                                                                                                                                                                                                                                                                                             |   | N/A                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| ·          Will ensure that Product Manufactured is appropriately tested      according to agreed upon sampling and testing plans, Product Specification      and approved procedures.                                                                                                                                                                                                                                                          |   | N/A                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| ·          Jointly review, approve and issue process    descriptions.                                                                                                                                                                                                                                                                                                                                                                           |   | ·          Complete review of technical content, resolution of any questions      and approval of process description within [***] from date of receipt or      within another timeline that has been mutually agreed by Micromet and      Lonza. Approval to be captured via the Micromet approvalForm; ·          Subsequent updates to technical content will be captured by change      control (see under      Section 6.5 below). |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| ·          Prepare master Batch Records for each processing step and make      available for Micromet to review during audit or other mutually defined      frequency.                                                                                                                                                                                                                                                                          |   | ·          Review master Batch Records for accuracy of technical content for      each processing step and agree.                                                                                                                                                                                                                                                                                                                                                     |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| ·          Define specifications and perform in-process controls and testing      program.                                                                                                                                                                                                                                                                                                                                                      |   | ·          Agree in-process testing strategy.                                                                                                                                                                                                                                                                                                                                                                                                                         |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| ·          With Micromet, define process validation plans and timing for      Product including analytical validation and stabilitystudies; ·          Annex 3      contains additional considerations for Product intended for commercial      use.                                                                                                                                                              |   | ·   With Lonza, define process validation      plans and timing for Product including analytical validation and stability      studies; ·          Annex 3      contains additional considerations for Product intended for commercial      use.                                                                                                                                                                                             |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| ·          Designate unique Batch numbers for Raw Materials, process materials      and Product.                                                                                                                                                                                                                                                                                                                                                |   | N/A                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| ·          Maintain the Specifications file for Product ·          Notify Micromet of any changes to the Specifications      file; ·          Assurance of consistency of current Specifications file and IMPD/      IND versions and notify Micromet.                                                                                                                              |   | N/A                                                                                                                                                                                                                                                                                                                                                                                                                                                                                            |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                     |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                           |
| ·          Unless due to emergency whereby product integrity is at risk, Lonza      will not Reprocess Product without prior notification and written approval      of Micromet.                                                                                                                                                                                                                                                           |   | ·          If notification received prior to Reprocessing by Lonza, complete      review, resolution of any questions and approval of Reprocessing requests      within [***]; ·          Following emergency Reprocessing by Lonza, complete review,      resolution of any questions and approval of Reprocessing      deviation/investigation within[***].                                                                           |

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| ·          Provide documented reason and justification for Reprocessing      event.                                             |   | N/A                                                                                                                                                  |
|----------------------------------------------------------------------------------------------------------------------------------------------------------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                     |   |                                                                                                                                                 |
| ·          With Micromet, agree the appropriate testing required prior to the      release of processed or Reprocessed Product. |   | ·          With Lonza, agree the appropriate testing required prior to the      release of processed or ReprocessedProduct. |

| 4.4        Product      Storage, Labeling, Packaging and Shipment                                                                                                          |
|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Lonza      Responsibility                                                                                                                                                                                          |   | Micromet      Responsibility |
| ·          Will maintain procedures to ensure Product is stored under      appropriate environmental conditions as defined by    Micromet.                                                |   | ·          Specify to Lonza all applicable storage requirements for      Product. |
|                                                                                                                                                                                                               |   |   |
| ·          Store, label and package (including transport packaging) Product as      defined in the Product Specification.                                                                 |   | N/A |
|                                                                                                                                                                                                               |   |   |
| ·          Notify Micromet of proposed shipment date.                                                                                                                                     |   | ·          Agree shipment date. |
|                                                                                                                                                                                                               |   |   |
| ·          Ship Product on behalf of Micromet to locations designated by      Micromet.                                                                                                   |   | ·          Acknowledge receipt of Product in writing within [***] of      receipt. |
|                                                                                                                                                                                                               |   |   |
| ·          Provide generic shipping validation data, where available, for      Product if requested by Micromet.                                                                          |   | ·          Provide Product specific shipping validation OR, where applicable,      request in writing to utilize Lonza generic shipping validation for      Product. |
|                                                                                                                                                                                                               |   |   |
| ·          If Product is to be shipped under quarantine ensure written      confirmation received from Micromet to authorise shipment of Product under      quarantine prior to shipment. |   | ·          Provide Lonza with written confirmation to authorise shipment of      Product underquarantine. |

| Lonza      Responsibility                                                                                                                                                    |   | Micromet      Responsibility                                                                                                                                                                                                                                                                                         |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| ·          Assess and approve contract testing laboratories for Raw Material,      Cell Banks, Product Release testing and Drug Product    testing. |   | N/A                                                                                                                                                                                                                                                                                                                  |
|                                                                                                                                                                         |   |                                                                                                                                                                                                                                                                                                                 |
| ·          Notify Micromet of contract testing laboratories used for Product      Release testing and Drug Product testing.                         |   | ·          Agree proposed use of contract testing  laboratories.                                                                                                                                                                                                                            |
|                                                                                                                                                                         |   |                                                                                                                                                                                                                                                                                                                 |
| ·          Audit contract testing laboratories in accordance with GxP      guidelines and confirm audit to Micromet in writing.                     |   | N/A                                                                                                                                                                                                                                                                                                                  |
|                                                                                                                                                                         |   |                                                                                                                                                                                                                                                                                                                 |
| ·          Facilitate audit by Micromet if requested.                                                                                               |   | ·          May perform audits of Lonza contract testing laboratories providing      Micromet is authorized to do so by the contract laboratory and accompanied      by a Lonza representative.                                                                                              |
|                                                                                                                                                                         |   |                                                                                                                                                                                                                                                                                                                 |
| ·          Review and approve Micromet strategy and deliverables for      establishing analytical methods for process.                         |   | ·          Define strategy and deliverables for establishing analytical      methods to be used in support of process, including: o     Methods to be developed by      Lonza; o     Methods to be transferred      to Lonza fromexternal |

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| ·          Will submit any proposed major changes to analytical methods      related to the testing of Product and Drug Product to Micromet for review      and approval prior to the implementation of such changes. Change request      notification and approval will be documented according to the applicable      SOP. |   | ·          Will submit any proposed major changes to analytical methods      related to the Drug Product and Product to Lonza for review and approval      prior to the implementation of such changes. Change request notification      and approval will be documented.                                                                |
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                                                                                                                  |   |                                                                                                                                                                                                                                                                                                                                                              |
| ·          Will not implement proposed major changes until written approval is      received from Micromet.                                                                                                                                                                                                                  |   | N/A                                                                                                                                                                                                                                                                                                                                                               |
|                                                                                                                                                                                                                                                                                                                                                  |   |                                                                                                                                                                                                                                                                                                                                                              |
| ·          Will be responsible for performing [***] identification test on      each lot of Raw Materials in accordance with approved analytical methods      and specifications, compendial methods and SOPs.                                                                                                               |   | N/A                                                                                                                                                                                                                                                                                                                                                               |
|                                                                                                                                                                                                                                                                                                                                                  |   |                                                                                                                                                                                                                                                                                                                                                              |
| ·          Will be responsible for performing all in-process testing in      accordance with approved procedures.                                                                                                                                                                                                            |   | N/A                                                                                                                                                                                                                                                                                                                                                               |
|                                                                                                                                                                                                                                                                                                                                                  |   |                                                                                                                                                                                                                                                                                                                                                              |
| ·          Will provide Micromet with a Certificate of Analysis and a      Certificate of Compliance as well as a QP Certification statement      individually or as combined documentation.                                                                                                                                 |   | N/A                                                                                                                                                                                                                                                                                                                                                               |
|                                                                                                                                                                                                                                                                                                                                                  |   |                                                                                                                                                                                                                                                                                                                                                              |
| ·          Perform Product and Drug Product testing against Product and Drug      Product Specification.                                                                                                                                                                                                                     |   | N/A                                                                                                                                                                                                                                                                                                                                                               |
|                                                                                                                                                                                                                                                                                                                                                  |   |                                                                                                                                                                                                                                                                                                                                                              |
| ·          Notify Micromet of confirmed out of Specification results (OOS)      regarding Product Release testing and Drug Product testing.within target      of [***], not to exceed [***], of the OOS being confirmed.                                                                                                     |   | ·          Complete review, resolution of any questions and approval of      investigation reports within [***] regarding any out of Specification      result (OOS) of Product and Drug Product ·          For target specifications agree impact on quality and safety of      Product and Drug Product. |
|                                                                                                                                                                                                                                                                                                                                                  |   |                                                                                                                                                                                                                                                                                                                                                              |
| ·          Will provide Micromet with a written report on the investigation      and resolution of the OOS test result within [***] of confirmation of the      result, unless granted approval by Micromet for a longer      period.                                                                                        |   | N/A                                                                                                                                                                                                                                                                                                                                                               |
|                                                                                                                                                                                                                                                                                                                                                  |   |                                                                                                                                                                                                                                                                                                                                                              |
| ·          Take bulk Product retention samples from each Batch with sufficient      volume for at least [***] full biochemical Product Specification      analyses for use in the event of an investigation on Product Released for      clinical trial supply.                                                         |   | ·          Define number of samples required to complete full biochemical      analysis.                                                                                                                                                                                                                                                 |
|                                                                                                                                                                                                                                                                                                                                                  |   |                                                                                                                                                                                                                                                                                                                                                              |
| ·          Store retains under appropriate conditions for the period defined      in SOPs.                                                                                                                                                                                                                                   |   | N/A                                                                                                                                                                                                                                                                                                                                                               |
|                                                                                                                                                                                                                                                                                                                                                  |   |                                                                                                                                                                                                                                                                                                                                                              |
| ·          Upon completion of sample retention period notify Micromet of      option to either destroy or ship retention in accordance with      SOPs.                                                                                                                                                                       |   | ·          Within [***] respond in writing to Lonza and approve destruction of      samples or request receipt ofsamples.                                                                                                                                                                                                                |

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| ·          Jointly agree to analytical method development and/or method      transfer strategy for Product and Drug product testing; ·          Strategy to include deliverables for all applicable methods to be      developed, validated, transferred and qualified, as      applicable. |   | ·          Jointly agree to analytical method development and/or method      transfer strategy for Product testing; ·          Strategy to include deliverables for all applicable methods to be      developed, validated, transferred and qualified, as      applicable. |
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                                                                                                               |   |                                                                                                                                                                                                                                                                                                                              |
| ·          Will be responsible for qualifying and maintaining all laboratory      equipment used for all testing applicable to the Manufacture of      Product.                                                                                                                                                           |   | N/A                                                                                                                                                                                                                                                                                                                               |
|                                                                                                                                                                                                                                                                                                                                               |   |                                                                                                                                                                                                                                                                                                                              |
| ·          Perform Product stability testing according to Development and      Supply Agreement;·          Prepare stability protocols.                                                                                                                                                          |   | ·          Jointly define stability testing requirements and      responsibilities;·          Approve stability protocols.                                                                                                                                                      |
|                                                                                                                                                                                                                                                                                                                                               |   |                                                                                                                                                                                                                                                                                                                              |
| ·          Notify Micromet within target of [***], not to exceed [***], of any      confirmed stability failure of the Product at the intended storage      temperature.                                                                                                                                                  |   | ·          Acknowledge receipt of Lonza notification, in writing, within      [***].                                                                                                                                                                                                                |
|                                                                                                                                                                                                                                                                                                                                               |   |                                                                                                                                                                                                                                                                                                                              |
| ·          Prepare, characterise and store Product reference standard per      SOPs.                                                                                                                                                                                                                                      |   | ·          Agree to reference characterisation package.                                                                                                                                                                                                                                                  |
|                                                                                                                                                                                                                                                                                                                                               |   |                                                                                                                                                                                                                                                                                                                              |
| ·          Provide reference standard characterisation report to      Micromet.                                                                                                                                                                                                                                           |   | ·          Agree to reference characterisation package.                                                                                                                                                                                                                                                  |
|                                                                                                                                                                                                                                                                                                                                               |   |                                                                                                                                                                                                                                                                                                                              |
| ·          Store characterised Product reference standard under appropriate      conditions as per SOPs.                                                                                                                                                                                                                  |   | ·          Supply characterised Product reference standard with      Certificate of Analysis.                                                                                                                                                                                                  |

| 6.1        Complaints,      Recalls and Adverse Events                                                                                                                                                                                                                       |
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Lonza      Responsibility                                                                                                                                                                                                                                                                                            |   | Micromet      Responsibility |
| ·          Upon request, support Micromet in their Product complaint or      adverse event investigations for events possibly related to      Lonza; ·          Jointly agree to investigation plan, actions and time lines for      response, as applicable. |   | ·          Receive and investigate Product complaint and adverse events and      request Lonza support, as applicable; ·          Jointly agree to investigation plan, actions and time lines for      response, as applicable; ·          Responsible for all notifications to regulatory agencies, as      applicable, related to product complaints or adverse    events. |
|                                                                                                                                                                                                                                                                                                                 |   |   |
| ·          Upon request, support Micromet in activities related to Product      recall where recall relates to Lonza.                                                                                                                                                                       |   | ·          Responsible for decision to initiate a Product recall; ·          Responsible for overall management of Product recall      activities. |

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| 6.2        Batch      Review and Product Disposition                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Lonza      Responsibility                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                             |   | Micromet      Responsibility |
| ·          Review Batch Record for compliance to cGMP, SOPs and the Product      Specification.                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Will provide Micromet upon its request, one (1) agreed copy of      Product Batch documentation for each production Batch (as detailed in      Annex 4). This      will include Product analysis as defined in the Product Specification, a      summary of Batch related deviations, environmental monitoring summaries,      TSE / BSE statements, Certificate of Compliance, Release certificate.      Proprietary information such as media and feed preparations may be      excluded. Lonza to provide information directly to regulatory      authorities. |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Prepare Certificate of Analysis for Product as specified      by Micromet.                                                                                                                                                                                                                                                                                                                                                                                                                                                                              |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  |   |   |
| ·          Responsible for Certification of Product to Micromet "for use in      further manufacturing" of clinical trial materials by a Qualified      Person.                                                                                                                                                                                                                                                                                                                                                                                                              |   | ·          Responsible for Certification of Product for use in clinical trials      and/or markets supplied (unless otherwise specified contractually with      Lonza). |

| 6.3        Records      Retention                                                                                                                                                                                                                                                   |
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Lonza      Responsibility                                                                                                                                                                                                                                                                                                   |   | Micromet      Responsibility |
| ·          Retain records associated with Manufacture of Product and testing      of Product and Drug Product, including records associated with the      inspection and Release of Raw Materials and primary packaging components,      for minimum of [***] from date of Manufacture of Product. |   | N/A |
|                                                                                                                                                                                                                                                                                                                        |   |   |
| ·          Notify Micromet of intent to destroy records with option to send      records (Lonza proprietary information will be omitted) to      Micromet OR ·          Agree terms with Micromet for future storage.                                           |   | ·          Approve destruction or request receipt of  records. |

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| 6.4        Deviations      / Investigation Reports                                                                                                                                                                                                                                                                                                                                                                                                                                                |
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Lonza      Responsibility                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                 |   | Micromet      Responsibility |
| ·          Deviation handling, investigation and clarification of any cell      culture contamination, any deviation potentially bearing a risk of a      defective batch run, potential loss of a batch due to technical defects or      operator errors ·          General deviation handling in accordance with Lonza procedures,      initiate deviations/investigations, evaluate and define follow up actions      and final approval of deviations / investigation reports. |   | N/A |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |   |   |
| ·          Notify Micromet of all significant deviations within target of      [***], not to exceed [***] of the event; ·          A significant deviation is as defined as per Lonza’s relevant      SOPs; ·          Upon request, provide Micromet with copy of draft report of      significant deviation for review and comments.                                                                                                    |   | ·          Acknowledge receipt of significant deviation draft report, in      writing, within [***]; ·          Provide any questions/comments to draft Lonza report within      [***]. |
| ·          Notify Micromet of failed Batches within target of [***], not to      exceed [***] of failure being identified.                                                                                                                                                                                                                                                                                                                                                                                       |   | ·          Acknowledge receipt of failure investigation draft report, in      writing, within [***]; ·          Provide any questions/comments to draft Lonza report within      [***]. |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                      |   |   |
| ·          Within target of [***], not to exceed [***], notify Micromet of any      events noted which may impact Batches previously shipped or      Released; ·          Upon request, provide Micromet with copy of draft report of noted      deviation for review and comments.                                                                                                                                                                                                |   | ·          Acknowledge receipt of notification, in writing, within      [***]; ·          Provide any questions/comments to draft Lonza report within      [***]. |

| 6.5        Change      Control Procedures                                                                                                                                                                                    |
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Lonza      Responsibility                                                                                                                                                                                                                                            |   | Micromet      Responsibility |
| ·          For a Product specific change proposed by Micromet: process change      through change control and notify Micromet of change      approval.  If change rejected discuss reasons for rejection with      Micromet.      |   | ·          Propose Micromet changes and provide rationale in      writing. |
|                                                                                                                                                                                                                                                                 |   |   |
| ·          Will provide Micromet with all information required to evaluate the      proposed changes and, if necessary, obtain amended clinical trial      applications, as applicable.                                                     |   | N/A |
|                                                                                                                                                                                                                                                                 |   |   |
| ·          Lonza will not implement major changes (i.e., changes which are      relevant for regulatory approval) until written change request approval is      received from Micromet.                                                     |   | ·          Approval of major change or rejection. |
|                                                                                                                                                                                                                                                                 |   |   |
| ·          For major changes proposed by Lonza, Lonza will provide Micromet      with all information required to evaluate such proposed changes and, if      necessary, to obtain amended clinical trial applications, as      applicable. |   | N/A |

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| ·          Notify Micromet, through change control, of any proposed changes to      Product or process specific attributes prior to      implementation.      |   | ·          Complete review, resolution of any questions and approval within      [***] of receipt of change controls. |
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|------------------------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                   |   |                                                                                                                                           |
| ·          Inform Micromet of changes to key personnel.                                                                                                       |   | N/A                                                                                                                                            |
|                                                                                                                                                                                   |   |                                                                                                                                           |
| ·          Notify Micromet, through change control, of relevant changes to      major equipment, premises and utilities used for Manufacture of      Product. |   | ·          Acknowledge receipt of notification, in writing, within      [***].                                        |
|                                                                                                                                                                                   |   |                                                                                                                                           |
| ·          With Micromet, define strategy for notifying change      to regulatory agency as appropriate.                                                 |   | ·          With Lonza, define strategy for notifying changes      to regulatory agency asappropriate.                 |

| 7.1             Regulatory Agency Inspections                                                                                                                                                                    |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Lonza      Responsibility                                                                                                                                                                                                                      |   | Micromet      Responsibility |
| ·          Provide Micromet with daily verbal debriefs of inspection scope      during inspections.                                                                                                                   |   | ·          Provide required technical, quality and regulatory representatives      on site for pre-approval inspections, as agreed with Lonza; ·          Provide up to [***] ([***] to be agreed by Lonza) to be present      directly in meetings with agency inspectors. |
|                                                                                                                                                                                                                                           |   |   |
| ·          Provide copies of inspection reports and notify Micromet of      proposed responses and corrective action plans regarding the Product,      process or systems relating to Product.                        |   | ·          Agree on proposed inspection responses to observations relevant to      Product. |
|                                                                                                                                                                                                                                           |   |   |
| ·          Inform Micromet of any regulatory agency inspections at      Facilities.                                                                                                                                   |   | ·          For regulatory agency inspections regarding Product provide      assistance to Lonza. |
|                                                                                                                                                                                                                                           |   |   |
| ·          Notify Micromet of inspection observations (including deficiency      letters) regarding the Product, process or systems relating to the      Product.                                                     |   | ·          Agree on proposed inspection responses to observations relevant to      Product. |
|                                                                                                                                                                                                                                           |   |   |
| ·          Will permit an employee and/ or consultant and/or successor of      Micromet or Micromet's sublicensee(s) to be present as silent      observer.                                                           |   | N/A |
|                                                                                                                                                                                                                                           |   |   |
| ·          Will appropriately and promptly correct verifiable complaints of      regulatory agencies; ·          Will implement appropriate actions as agreed upon by the      Parties. |   | ·          Agree on proposed actions to complaints by regulatory      agencies. |

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| 7.2 | Regulatory      Authorizations / Submissions |
|-----|----------------------------------------------|

| Lonza Responsibility                                                                                                                                                                                                                                                                         |   | Micromet Responsibility                                                                                                                                                                                                                                       |
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                                                         |   |                                                                                                                                                                                                                                                          |
| ·          Maintain      all licenses and authorizations as are required by Applicable Laws to      operate a cGMP pharmaceutical bulk manufacturing, packaging, and/or      testing facility.                                                                      |   | N/A                                                                                                                                                                                                                                                           |
|                                                                                                                                                                                                                                                                                         |   |                                                                                                                                                                                                                                                          |
| ·          Will provide copies of all documentation necessary for Micromet to      respond to inquiries by regulatory agencies relating to      Product.                                                                                                            |   | ·          Will provide copies of all documentation necessary for Lonza to      respond to inquiries by regulatory agencies relating to      Product.                                                                                |
|                                                                                                                                                                                                                                                                                         |   |                                                                                                                                                                                                                                                          |
| ·     Provide      data pack to Micromet covering activities performed by Lonza (Lonza      proprietary information will be omitted) for review and      comment; ·     Provide      Micromet with final copy of data pack. |   |  ·          Review and comment on draft data pack.                                                                                                                                                                              |
|                                                                                                                                                                                                                                                                                         |   |                                                                                                                                                                                                                                                          |
|  ·     For      US submissions, provide letter authorising cross referral to [***] if      requested by Micromet.                                                                                                                                         |   | ·          Provide Lonza with copy of relevant sections of regulatory      application as submitted to regulatory agency.                                                                                                            |
|                                                                                                                                                                                                                                                                                         |   |                                                                                                                                                                                                                                                          |
|  ·     Review      and comment on relevant sections of Micromet’s regulatory      application.                                                                                                                                                      |   | ·     Prepare      and provide Lonza with copy of relevant sections of regulatory application      for review and comment prior to submission to regulatory      agency.                                                        |
|                                                                                                                                                                                                                                                                                         |   |                                                                                                                                                                                                                                                          |
|  N/A                                                                                                                                                                                                                                                                                    |   | ·          Provide Lonza with copy of relevant sections of regulatory      application as submitted to regulatory agency.                                                                                                            |
|                                                                                                                                                                                                                                                                                         |   |                                                                                                                                                                                                                                                          |
| ·     Attend      teleconferences and meetings between Micromet and regulatory agencies      arranged to specifically discuss topics relating to Lonza’s      responsibilities, if requested by Micromet.                                           |   | ·          Arrange for Lonza personnel to have option to attend      teleconferences and meetings between Micromet and regulatory agencies      to specifically discuss topics relating to Lonza’s      responsibilities. |

| 8.  | Micromet      Oversight |
|----------|-------------------------|

| 8.1 | Audit      Allowance |
|-----|----------------------|

| Lonza Responsibility                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   | Micromet Responsibility                                                                                                                                                                                                                                                                                |
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |                                                                                                                                                                                                                                                                                                   |
| ·     [***] standard      cGMP compliance audit permitted per [***] and per [***], not to exceed      [***] and [***]; ·          Will permit Micromet's Person-in-Plant (PiP) observe Works and      Services in accordance with the Development and Supply      Agreement; ·          Micromet may request ‘for cause’ audits and investigations to      address Product quality issues after prior notification. |   |  ·     Provide      reasonable notice of intention to audit; ·     Hold      an exit meeting to discuss observations; ·     Provide      an audit report within [***] of completion of audit. |
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                |   |                                                                                                                                                                                                                                                                                                   |
| ·     Permit      Micromet representatives or third parties commissioned by Micromet for a      permitted audit to have access to GMP warehousing, manufacturing areas,      laboratories and Manufacturing documents including all standard operating      procedures (Lonza proprietary information will be omitted) for audit      purposes; ·          Micromet representatives to be escorted at all times by Lonza      personnel.                                |   |   N/A                                                                                                                                                                                                                                                                                        |

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| ·     Per      lot, allow a [***] on site review for up to [***] to review completed      process Batch Records, if requested by Micromet.                                                           |   | ·     Per      lot, provide reasonable notice of intention to review executed Batch      Records. |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|---------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                               |   |                                                                                                                            |
| ·     Provide      a written response to all audit findings that require corrective action      within [***] of receipt of the audit report.  Response to      include expected timelines. |   |  N/A                                                                                                                       |
|                                                                                                                                                                                                                               |   |                                                                                                                            |
| ·     Will      appropriately and promptly correct any defects found by audits and      inspections and take any necessary action.                                                                   |   |  N/A                                                                                                                       |
|                                                                                                                                                                                                                               |   |                                                                                                                            |
| ·     The      QP responsible for final Release or [***] is entitled to attend all      production campaigns of Product at the Facility as detailed in the      Development and Supply Agreement.    |   |                                                                                                                            |

| 8.2 | Periodic      Review of Quality Agreement |
|-----|-------------------------------------------|

| Lonza Responsibility                                                                                                                              |   | Micromet Responsibility                                                                                                        |
|---------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                              |   |                                                                                                                           |
| ·     Jointly      review Quality Agreement and revise, as necessary, at least every      [***].                    |   | ·     Jointly      review Quality Agreement and revise, as necessary, at least every      [***]. |
|                                                                                                                                              |   |                                                                                                                           |
| ·     Written      approval from both Parties for any amendments to the Quality      Agreement.                     |   | ·     Written      approval from both Parties for any amendments to the Quality      Agreement.  |
|                                                                                                                                              |   |                                                                                                                           |
| ·     Will      provide revision control of the Quality Agreement and issue a revised      document as appropriate. |   | N/A                                                                                                                            |

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| 9.  | Term |
|----------|------|

| 10.  | Miscellaneous |
|-----------|---------------|

| 10.1 | Sections      1 (Definitions and Interpretation), 5 (Inspections; Person in Plant), 10      (Confidentiality), 15 (Force Majeure), 16 (Governing Law, Jurisdiction and      Enforceability), 17 (Illegality) and 20.1 (Affiliates; Assignment) of the      Development and Supply Agreement shall also apply to this Quality      Agreement. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.2 | In      case of conflicts between this Quality Agreement and the Development and      Supply Agreement, the provisions of the Development and Supply Agreement      shall govern and control. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.3 | No      variation of or addition to this Quality Agreement or any part thereof      shall be effective unless in writing and signed on behalf of both      Parties.  Notwithstanding the above the Parties hereby confirm      that amendments to the Product Specification and the Drug Product      Specifications shall be effective if reduced to writing and signed by the      quality and/or regulatory representative of both Parties, which quality      and/or regulatory representative shall be nominated from time to time by      each Party. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| Micromet      AG                                      |                 | Lonza      Sales AG                               |
|-------------------------------------------------------|----------------------|---------------------------------------------------|
|                                                  |                 |                                              |
| Signature:                                            | /s/ Jens Hennecke    |                                              | Signature: | /s/ Una Hultry |
| Printed      Name:  Jens Hennecke           |                 | Printed      Name:   Una Hultry    |
| Title:   SVP      Business Development |                 | Title:   Authorized      Signatory |
|                                                  |                 |                                              |
| Signature:                                            | /s/ Patrick Baeuerle |                                              | Signature: | /s/ Gerry Kennedy |
| Printed      Name:  Patrick Baeuerle        |                 | Printed      Name:   Gerry Kennedy |
| Title:  SVP,      Chief Scientific Officer  |                 | Title:  Authorized      Signatory       |

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

| Micromet                                 |                | Lonza                                 |
|------------------------------------------|---------------------|---------------------------------------|
|                                     |                |                                  |
| Head      of Quality: Klaus Buchweitz    |                | Head      of Quality (LBP): Sue Crowe |
|                                     |                |                                  |
| Signature:                               | /s/ Klaus Buchweitz |                                  | Signature: | /s/ Sue Crowe |
|                                     |                |                                  |
| Head      of Manufacturing: Thomas Urbig |                | Head      of Operations: GordonBates  |

| Signature: | /s/ Thomas Urbig |   | Signature: | /s/ GordonBates |
|------------|------------------|--------|------------|-----------------|

| Head      of Quality Control: Andreas Wolf |   | Head      of Quality Control: KymBaker |
|--------------------------------------------|--------|----------------------------------------|

| Signature: | /s/ Andreas Wolf |   | Signature: | /s/ KymBaker |
|------------|------------------|--------|------------|--------------|

----

| Execution      Copy | Schedule      10 |   |
|---------------------|------------------|--------|

----

| Micromet                            |   | Lonza                               |
|-------------------------------------|--------|-------------------------------------|
| Head      of Site: N/A              |   | Head      of Site: [***]            |
|                                |   |                                |
|                                |   | Tel:                                | [***] |
|                                |   | Fax:                                | [***] |
|                                |   | Email:                              | [***] |
|                                |   |                                |
| Head      of Quality: [***]         |   | Head      of Quality: [***]         |
|                                |   |                                |
| Tel:                                | [***]  |                                | Tel: | [***] |
| Fax:                                | [***]  |                                | Fax: | [***] |
| Email:                              | [***]  |                                | Email: | [***] |
|                                |   |                                |
| Head      of Manufacturing: [***]   |   | Head      of Operations: [***]      |
|                                |   |                                |
| Tel:                                | [***]  |                                | Tel: | [***] |
| Fax:                                | [***]  |                                | Fax: | [***] |
| Email:                              | [***]  |                                | Email: | [***] |
|                                |   |                                |
| Head      of Quality Control: [***] |   | Head      of Quality Control: [***] |
|                                |   |                                |
| Tel:                                | [***]  |                                | Tel: | [***] |
| Fax:                                | [***]  |                                | Fax: | [***] |
| Email:                              | [***]  |                                | Email: | [***] |

----

----

| Site Specific Responsibility                                         |   | Responsible Lonza Facility |   | Comments                                                                                                   |
|--------------------------------------------------------------------------------|--------|--------------------------------------|--------|------------------------------------------------------------------------------------------------------------|
|                                                                           |   |                                 |   |                                                                                                       |
| GMP      Manufacture, process development, cell bank creation and      storage |   | [***]                                |   | Primary      Manufacturing Facility ([***])                                                                |
|                                                                           |   |                                 |   |                                                                                                       |
| Serve      as back-up storage facility for Micromet's cell banks               |   | [***]                                |   | Storage      facility for Micromet cell banks                                                              |
|                                                                           |   |                                 |   |                                                                                                       |
| Pre-Licence      Stability Studies and Bioassays                               |   | [***]                                |   | Primary      Facility for stability studies and bioassays for Product produced at the      slough Facility |

----

----

| Lonza Responsibility                                                                                                                                  |   | Micromet Responsibility                                                                                                                                          |
|------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                       |   |                                                                                                                                                                  |
| ·          For Lonza supplied materials, finalize critical supplier and      critical Raw Material qualifications for the Product |   | ·           For Micromet supplied materials, finalize critical supplier and      critical Raw Material qualifications for the  Product. |

| Lonza Responsibility                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                   |   | Micromet Responsibility                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       |
|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        |   |                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               |
| ·      Jointly      with Micromet, define strategy and responsibilities for process validation      activities including (but not limited to): o         Process      validation master plan, protocols and reports (issued before phase III      material is manufactured); o         Product  specific      assay validations; o         Cleaning      validation of the  Product o         Hold      times for buffers/medias used in process; o         Intermediate  Product      stability; o         Product      yield specifications. |   | ·      Jointly      with Lonza, define strategy and responsibilities for process validation      activities including (but not limited to): o         Process      validation master plan, protocols and reports; o         Product  specific      assay validations; o         Cleaning      validation of the  Product o         Hold      times for buffers/medias used      in process; o         Product      stability; o         Product      yield specifications. |

----

----

----

----

----

----

----

----

----

| (1) | LONZA SALES AG, of      Muenchensteinerstrasse 38, CH-4004, Basel, Switzerland (hereinafter      referred to as “the      Licensor”). |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------|

| (2) | MICROMET AG, of      Staffelseestrasse 2, D-81477 Munich, Germany (hereinafter referred to as      “the Licensee”). |
|-----|---------------------------------------------------------------------------------------------------------------------------------|

| (A) | Pursuant      to the Development Agreement (as defined below), the Licensor has      performed certain development and manufacturing services on behalf of the      Licensee relating to the Product, and accordingly the Licensor possesses      confidential and proprietary information and data concerning the      manufacture of the Product. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (B) | The      Licensor and the Licensee have previously entered into the Development      Agreement dated November 23, 2009 relating to, inter alia, the Licensee’s      use of certain Intellectual Property of the Licensor in the research,      development and manufacture of theProduct. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (C) | The      Licensor has agreed to transfer the Product specific documentation and      appropriate information and grant the licenses needed for the Licensee and      its Permitted Sublicensees (as defined below) to replicate the Process in      the event Licensee or its successor exercises its option for a technology      transfer and license as set forth in Clause 14 of the Development      Agreement.  Upon exercise of the option, the Licensor shall make      available to the Licensee such confidential and proprietary information      and shall grant to the Licensee a non exclusive licence to use the      Licensed Know-How, the Licensed Patents and other Intellectual Property      for the further development and manufacture of the  Product. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1. | INTERPRETATION |
|----|----------------|

|  | 1.1 | The      definitions and rules of interpretation in this Clause apply in this TTL      Agreement. |
|--|-----|---------------------------------------------------------------------------------------------------|

|   | 1.1.1 | Affiliate means any company,      corporation, limited liability company, partnership or other entity which      directly or indirectly Controls, is Controlled by or is under common      control, directly or indirectly, with the relevant Party to this      Agreement.  Control for purposes of this Clause      1.1.1 shall mean the ownership of more than fifty percent (50%) of the      issued share capital of the Party in question or the legal power to direct      or cause the direction of the general management and policies of the Party      in question. |
|--------|-------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | 1.1.2 | Approved      Purpose means,      in relation to the Product only (and no other product), the further      development of the Process and the manufacture of the Product using the      Process and the Intellectual Property, the Licensed Know-How and the      Licensed Patents by the Licensee and/or its Permitted Sublicensees, and      the sale and use of the Product for any      purpose. |
|--------|-------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.1.3 | Control or      Controlled means      with respect to any (i) item of Information, including, without      limitation, know-how, or (ii) Intellectual Property, the possession      (whether by ownership or license, other than pursuant to this      TTL Agreement) by a Party of the ability to grant to the other Party      access or a license as provided herein under such item or right without      violating the terms of any agreement or other arrangements with any Third      Party. |
|--------|-------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.1.4 | Development Agreementmeans that      certain agreement dated November 23, 2009 between the Licensor and the      Licensee relating to the development of the Process and the manufacture of      the Product. |
|--------|-------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.1.5 | Disclose includes discussion (or any      communication) or disclosure, by whatever means, and Disclosed,      Discloses, Disclosing and Disclosure are to be construed      accordingly, and in relation to an obligation to Disclose means the most appropriate form      of Disclosure. |
|--------|-------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.1.6  | Effective Date of this TTL Agreement means the date on which the      Licensee exercises the option for a technology transfer and license in      accordance with Clause 14 of the Development      Agreement.                                                                                                                                                |
|--------|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   |   |                                                                                                                                                                                                                                                                                                                                                          |
|   | 1.1.7  | Improvement means      any addition, alteration, change, development, enhancement, improvement or      modification to and non-severable from the Licensed Know-How and/or      Licensed Patents, and includes all Information in respect of the same, to      the extent severable from the Product and the Licensee’s patents and      know-how. |

|   | 1.1.8 | Informationmeans any information,      including technical information and know-how, obtained from development,      experimentation, observation and operation by the Disclosing Party or on      its behalf or to which it is or becomes entitled and all analyses,      assessments, data, designs, details, diagrams, drawings, opinions,      specifications and statements in the Control and possession or within the      knowledge of the Disclosing  Party. |
|--------|-------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | 1.1.9 | Intellectual Propertymeans all intellectual property      rights, including (without limitation) patents, patent applications,      divisions, continuations, continuation-in-part applications, divisionals,      substitutions, confirmations, supplementary protection certificates,      reissues, utility models, trademarks, database rights and copyrights and      all inventions, know-how, trade secrets, techniques and confidential      information and other proprietary knowledge and information which may      subsist anywhere in the world, in each case for their full term, and      together with any renewals or    extensions. |
|--------|-------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.1.10 | Licensed      Know-How means      all technical and other Information or data owned or Controlled by the      Licensor and used in the development and/or manufacture of the      Product.  Licensed Know-How shall include but not be limited to      scientific, technical, and commercial information relating to the Process,      such as specifications, know-how, technologies, manufacturing processes,      research, inventions and the Licensor’s commercial activities, and further      including any know-how comprised in the New General Application      Intellectual Property, as defined in the Development Agreement as      well as know-how comprised in the Improvements.  In the event      the Licensee exercises its option under Clause 14 of the Development      Agreement also for a technology transfer and license of the [***],      Licensed Know-How shall also include the [***].  Without      limiting the foregoing, the Lonza Know How as of the effective date of the      Development Agreement is identified in Schedule      A and      Schedule      C hereto. |
|--------|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.1.11 | Licensed      Patents means      patents and patent applications, divisions, continuations,      continuation-in-part applications, divisionals, extensions, substitutions,      renewals, confirmations, supplementary protection certificates and      reissues, throughout the world owned      or Controlled by the Licensor and used in the development and/or      manufacture of the Product.  Licensed Patents shall also      include, but not be limited to patents and patent applications that cover      the New General Applications Intellectual Property, as defined in the      Development Agreement, as well as patents and patent applications      comprised in the Improvements.  In the event the Licensee      exercises its option under Clause 14 of the Development Agreement also for      a technology transfer and license of the [***], Licensed Patents shall      also include the [***].  Short particulars of the Licensed      Patents as of the effective date of the Development Agreement are set out      in Schedule      B hereto. |
|--------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | 1.1.12 | Lonza means Lonza Sales AG and its      Affiliates Lonza Biologics plc of Slough, England, Lonza Biologics Inc of      Portsmouth, NH, USA, and Lonza Biologics Porriño S.L. of      Pontevedra-Galicia,Spain. |
|--------|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.1.13 | Micromet means Micromet AG and its      existing Affiliates which are engaged in the research and development of      BiTE® antibodies, and their      successors in title and lawful    assigns. |
|--------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.1.14 | Net Selling Price means all monies received by      or on behalf of the Licensee or its sublicensee hereunder in respect of      the sale of Product in the Territory to a Third Party in a bona fide arm's      length transaction, less the following items to the extent that they are      paid or allowed and included in the invoice price, whether or not invoiced      separately, and determined in accordance with consistently applied and      recognized accounting  standards: |
|--------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a) | normal      discounts actually granted, including without limitation, quantity, trade,      cash and other discounts, rebates and charge-backs, including government      rebates, governmental price reductions and  charges; |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (b) | amounts      refunded or credits allowed for Product or other goods returned or not      accepted by customers; |
|--------|-----|-----------------------------------------------------------------------------------------------------------------|

|   | (c) | packaging,      transportation and prepaid insurance charges on shipments or deliveries to      customers; and |
|--------|-----|----------------------------------------------------------------------------------------------------------------|

|   | (d) | taxes,      tariffs, customs duties, surcharges and other governmental charges      actually incurred and paid by Licensee or its sublicensee hereunder in      connection with the sale, exportation, importation or delivery of Product      or other goods to customers. |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | 1.1.15 | Party / Parties means Licensor or      Licensee, or Licensor and Licensee, as the context      permits. |
|--------|--------|--------------------------------------------------------------------------------------------------------------|

|   | 1.1.16 | Permitted Sub-licensee means a Third Party      collaboration partner of the Licensee or a Third Party who manufactures      the Product on behalf of the Licensee or the Third Party collaboration      partner of the Licensee subject to a sublicense in accordance with Clause      2.3 below. |
|--------|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.1.17 | Process means the process      (including but not limited to the fermentation process and the downstream      process) for the production of Product which is owned or Controlled by      Licensor and was further developed and/or improved and used for the      manufacture of Product by the Licensor under the Development      Agreement. |
|--------|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.1.18 | Product means      Licensee's single-chain bispecific anti-CD19 antibody (CD19      BiTE®)      also known as Blinatumomab or MT103, and any [***],      including [***]. |
|--------|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.1.19 | [***]means Licensor’s chemically defined, [***]      consisting of the [***] used either in combination or individually, as it      is used in the development and/or manufacture of the Product and owned or      Controlled byLicensor. |
|--------|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a) | [***] means [***], as more fully      set out in Schedule      C; |
|--------|-----|-------------------------------------------------------------------|

|   | (b) | [***] means [***], as more fully      set out in Schedule      C; |
|--------|-----|-------------------------------------------------------------------|

|   | (c)    | [***] means the [***] set out in      Schedule      C;                                                                                                                                                            |
|--------|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   |   |                                                                                                                                                                                                              |
|   | (d)    | [***] means any Information      specifically relating to the [***].  The [***] as of the      effective date of the Development Agreement is identified in more detail      in Schedule      C hereto; |

----

|   | (e) | [***] means any patents and      applications covering the [***].  The [***] as of the effective      date of the Development Agreement are identified in more detail in Schedule C      hereto; |
|--------|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (f) | [***] means the [***], as more      fully set out in Schedule      C. |
|--------|-----|-----------------------------------------------------------------------|

|   | 1.1.20 | Territorymeans      worldwide. |
|--------|--------|--------------------------------|

|   | 1.1.21 | Third      Party means      any party other than the Licensor and the  Licensee. |
|--------|--------|---------------------------------------------------------------------------------------|

|   | 1.1.22 | TTL Agreementmeans this Technology      Transfer and LicenseAgreement. |
|--------|--------|------------------------------------------------------------------------|

|   | 1.1.23 | Valid Claim means an issued claim      of an issued patent that has not (i) expired or been cancelled, (ii) been      declared invalid by a decision of a court or other appropriate body of      competent jurisdiction, from which no appeal is or can be taken, (iii)      been admitted to be invalid or unenforceable through reissue, disclaimer      or otherwise, or (iv) been abandoned or  disclaimed. |
|--------|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.2 | Any      reference to a Clause is to a Clause of this TTL Agreement, unless it      expressly refers to the DevelopmentAgreement. |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------|

|   | 1.3 | Clause      headings do not affect the interpretation of this TTL      Agreement. |
|--------|-----|-----------------------------------------------------------------------------------|

|   | 1.4 | Words      in the singular include the plural and in the plural include the      singular. |
|--------|-----|--------------------------------------------------------------------------------------------|

|   | 1.5 | A      reference to one gender includes a reference to the other      gender. |
|--------|-----|-------------------------------------------------------------------------------|

|   | 1.6 | A      person includes a corporate or unincorporated  body. |
|--------|-----|-------------------------------------------------------------|

|   | 1.7 | A      reference to a particular law is a reference to it as it is in force for      the time being taking account of any amendment, extension, application or      re-enactment and includes any subordinate legislation for the time being      in force made under it. |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 1.8 | Writing      or written includes faxes but note-mail. |
|--------|-----|-------------------------------------------------------|

| 2 | GRANT |
|---|-------|

|   | 2.1 | All      Intellectual Property in and to the Licensed Know-How and the Licensed      Patents and the [***] are and shall remain the exclusive property of the      Licensor.  Neither this TTL Agreement nor any Disclosure of the      Intellectual Property, the Licensed Know-How, the Licensed Patents, and      the [***] shall be deemed by implication or otherwise to vest in the      Licensee any present or future rights in any Intellectual Property, the      Licensed Know-How, the Licensed Patents, and the [***] and no licence is      granted except as explicitly stated in this TTL  Agreement. |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | 2.2 | The      Licensor hereby grants to the Licensee, and the Licensee accepts, in      relation only to the Product, a non exclusive licence to use the      Intellectual Property, the Licensed Know-How, the Licensed Patents and/or      the [***] to develop, have developed, to manufacture, have manufactured,      to supply, have supplied, to import, have imported, to use, have used, and      to sell and have sold, the Product in the Territory for the Approved      Purpose only. |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 2.3 | The Licensee shall have the right to authorize      and grant sub-licences through multiple tiers under this TTL Agreement to      specific [***] and any other Third Party registered and operating within      the permitted territories (but not to [***], their Affiliates or any other      Third Party registered and operating outside the permitted territories)      listed in Schedule      D (any [***] or Third Party other than those named, or outside      those territories listed, are to be assessed and consented to by Licensor      on a case by case basis, provided      that such consent by the Licensor shall not be unreasonably      withheld or delayed) with respect to the rights and licences granted under      this TTL Agreement, and further provided      that: |
|--------|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 2.3.1 | the      Licensee shall at all times indemnify and keep indemnified the Licensor      against all or any cost, claims, damages or expenses incurred by the      Licensor or for which the Licensor may become liable as a result of the      default or negligence of any sub-licensee, (including sub-sub-licensees,      and as further sub-licensed as the case may be), relating to this TTL      Agreement; and/or |
|--------|-------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 2.3.2 | each      sub-license, (including sub-sub-licensees, and as further sub-licensed as      the case may be), shall be expressly subject and subordinate to the terms      of this TTL Agreement, and it shall be the Licensee's responsibility to      ensure the strict adherence by any sublicensee hereunder to the terms and      conditions of this TTL Agreement. |
|--------|-------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 2.4 | With      regard to the [***] and provided      that the Licensee exercises its option regarding the [***] under      Clause 14 of the Development Agreement, the following provisions shall      apply: |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 2.4.1 | The      Licensor shall offer to Licensee [***].  Such new version shall      be made available at the price set forth in Clause 7.2 below, with the      only additional compensation being for additional Works and Services which      may be required to implement such improvement or new version for the      manufacture of the Product. |
|--------|-------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | 2.4.2 | The      Licensor shall provide the Licensee with details of a Third Party      supplier, from whom the Licensee and/or the Permitted Sub-licensee will be      able to purchase [***] to enable the Licensee and/or the Permitted      Sub-licensee, to make and use the [***], and the Licensor shall also      provide the Licensee or at Licensee's direction the Permitted Sublicensee      with the [***] to the extent required by the Licensee and/or the Permitted      Sub-licensee to use the [***], and to make and use the [***] for the      Approved Purpose. |
|--------|-------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 2.4.3 | For      the avoidance of doubt, the formulation of the [***] and/or the [***] will      not be Disclosed to the Licensee, and the Licensee hereby confirms that it      shall not perform any analysis, test, experiment, modification or      reverse-engineering on the [***].  With regard to any regulatory      filings necessary to support the Product, the Licensor shall file such      formulations directly with the appropriate regulatory      authority. |
|--------|-------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 2.4.4 | Upon      the request of Licensee, Licensor shall provide to the Licensee or      directly to the appropriate regulatory authority (as the case may be),      such documents and reasonable assistance regarding the [***] as may be      required to be submitted by Licensee in filings with any applicable      regulatory authorities for theProduct. |
|--------|-------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 2.4.5 | The      Licensor will provide to certain designated safety experts of the Licensee      or at the Licensee's direction its Permitted Sublicensee with [***] in      order to enable the Licensee or the Permitted Sublicensee to evaluate the      safety of the [***]. |
|--------|-------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 2.4.6 | The      Licensor shall use reasonable commercial endeavours to ensure continuity      of supply of the [***] and [***], through the establishment of a second      supplier where possible, the establishment of a second source from the      same supplier (e.g. second production site) or the establishment of supply      through an emergency plan/securitystock. |
|--------|-------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 2.4.7 | The      Licensee acknowledges that, subject only to [***]; certain Licensor      proprietary information (including the formulation for any elements of      [***]) may be a Licensor trade secret and will only be supplied [***] and      not to [***]. |
|--------|-------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 2.5 | No      right or licence is granted by the Licensor to the Licensee by this TTL      Agreement, except as expressly set out in this Clause 4. |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------|

|  | 2.6 | The      Licensor shall execute all documents, give all declarations regarding the      licenses granted under this Clause 2 and reasonably cooperate with the      Licensee to the extent such documents, declarations and/or cooperation are      required for the recordal or registration of the licenses granted      hereunder at the various patent offices for the benefit of the Licensee      and at the Licensee’s cost. |
|--|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

Execution Copy

| 3 | TECHNOLOGY      TRANSFER; PROVISION OF TECHNICAL  ASSISTANCE |
|---|--------------------------------------------------------------|

|   | 3.1 | The      Licensor shall transfer and make available to the Licensee, or at the      Licensee's direction to a Permitted Sub-licensee within [***] after the      Effective Date of this TTL Agreement (subject only to Clause 3.2) and from      time to time regarding the [***] a data package that shall include all of      the Information, Licensed Know-How, the Licensed Patents and, upon      exercise of the option regarding the [***] also the [***], in order to      enable the Licensee and/or the Permitted Sub-licensee, to develop,      manufacture, sell and use the Process and the Product.  The      Licensee and the Permitted Sub-licensee shall not use any of the know-how      furnished by the Licensor under this Clause 3 for any purpose whatsoever,      except for the Approved Purpose, or as otherwise specifically authorized      in writing by the Licensor.  In the event that the Licensee      reasonably believes that the Licensed Know-How, to the extent applicable,      included in the data package furnished by the Licensor under this Clause 3      is incomplete, the Licensee shall provide written notice thereof to the      Licensor, and the Licensor shall undertake reasonable efforts to furnish      the missing materials or amended copies of the missing know how and to      answer all reasonable questions received from the Licensee regarding the      Licensed Know How as soon as reasonably possible after receipt of the      Licensee's written notice. |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 3.2 | Upon      completion of the technology transfer under Clause 3.1, at the latest      [***] after the Effective Date of this TTL Agreement, the Parties shall      meet to discuss the status of the technology transfer, any missing      know-how and information and the assistance to be provided by the Licensor      in order to allow the Licensee or its Permitted Sub-licensee to      manufacture the Product using the Process.  The Licensee may      invite representatives of its Permitted Sub-licensees to participate in      such meeting. |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 3.3 | After      the Effective Date of this TTL Agreement and until [***] after the meeting      as set forth in Clause 3.2 above took place, the Licensor shall transfer      to the Licensee, or at the Licensee's discretion to its Permitted      Sub-licensee the [***].  Clause 3.1 above shall apply      respectively for the transfer of such[***]. |
|--------|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 3.4 | During      the term of this TTL Agreement, the Licensor shall reasonably make      available to the Licensee as outlined in the following sentence, the      services of fully qualified and experienced members of its staff to advise      the Licensee on the use of the Information, the Licensed Know-How, the      Licensed Patents and the [***] for the Approved Purpose.  Upon      prior written notice of the Licensee of at least [***] FTEs of the      Licensor will be available for technical assistance for the first [***]      after the Effective Date of this TTL Agreement.  Thereafter,      Licensor will be available for at least [***] during any [***] period. |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | 3.4.1 | the      Licensee reimburses the preapproved reasonable travel, hotel and living      expenses of such persons for the period from departure to      return; |
|--------|-------|--------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 3.4.2 | the      Licensee pays to the Licensor a fee for the services of such person in      relation to time spent with the Licensee and in travelling to and from the      Licensee at the Licensor’s then commercial daily      rate.  Licensor's commercial daily rate on the effective date of      the Development Agreement is [***] subject to annual UK's PPI      adjustments; |
|--------|-------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 3.4.3 | the      Licensor's representative shall act merely in an advisory capacity and      neither the Licensor nor such person shall be liable in any manner for any      loss (including, but not limited to, consequential loss, pecuniary loss      and loss of profits), damage or injury, other than (i) liability for death      or personal injury resulting from the implementation of or reliance on any      actual or alleged advice or assistance of such person or (ii) liability      resulting from the Licensor's or its representatives' negligence or wilful      misconduct; |
|--------|-------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 3.4.4 | for      the avoidance of doubt, the Licensor is not required to allow any      Permitted Sub-licensee access to its facilities and/or its trade      secrets. |
|--------|-------|----------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 4 | LICENSEE'S      OBLIGATIONS |
|---|-----------------------------|

|   | The      Licensee shall at all times indemnify, and keep indemnified, the Licensor      against all or any costs, claims, damages, liabilities or expenses      incurred by the Licensor or for which the Licensor may become liable with      respect to any product liability claim relating to the Product      manufactured by the Licensee, its sub-licensee or the Third Party contract      manufacturer of Licensee or its sub-licensee.  The Licensee      shall maintain adequate product liability insurance and shall supply to      the Licensor the policy on request.  |
|--------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5 | IMPROVEMENTS |
|---|--------------|

|   | 5.1 | The      Licensee undertakes that subject to any obligations as to confidence, the      Licensee must immediately Disclose to the Licensor any Improvements      created or developed by, for or on behalf of the Licensee upon it becoming      aware that an Improvement has been or may be created or      developed. |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|  | 5.2 | In      consideration of the rights granted under Clause 2 with respect to      Disclosure of the Licensed Know-How, Licensed Patents, and/or the [***]      all Intellectual Property in Improvements shall vest in and be owned by      the Licensor.  The Licensee hereby assigns to the Licensor, with      full title guarantee (subject only to the obligation to assign to      Licensor), such rights, title and interest in and to any Intellectual      Property in any Improvements it owns or will own, together with any      related rights and powers arising or accrued, including but not limited to      the rights to sue for damages (and the right to retain any damages      obtained) for all past infringements.  To the extent that any      assignment of future rights is prevented by law, the Licensee shall hold      any such right on trust for the Licensor absolutely until such purported      transfer of rights is perfected.  The Licensee further agrees to      execute or procure the execution of such deeds or documents and do or      procure the doing of such acts and things as may be necessary or desirable      to perfect the transfer of title to the Licensor or effect the recording      or registration of the assignment of any such Intellectual Property to the      Licensor (all reasonable costs incurred by the Licensee in providing such      co-operation shall be paid for by the Licensor).  Any such      Improvement transferred to the Licensor hereunder shall be considered      Licensed Know-How and/or Licensed Patents for purposes of this TTL      Agreement. |
|--|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6 | CONFIDENTIALITY |
|---|-----------------|

|   | 6.1 | The      Licensed Know-How and/or Licensed Patents may be Disclosed in electronic,      oral, written or other tangible form.  Any Information which is      orally or visually Disclosed to the Licensee shall constitute Licensed      Know-How: |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 6.1.1 | if      it would be apparent to a reasonable person, familiar with the Licensor’s      business and the industry in which it operates, that such Information is      of a confidential or proprietary nature the maintenance of which is      important to the Licensor; or |
|--|-------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 6.1.2 | if      the Licensor, within [***] after such Disclosure, delivers to the Licensee      a written document or documents describing such Information and      referencing the place and date of such oral, visual or written Disclosure      and the names of the persons at the receiving Party to whom such      Disclosure was made.  |
|--------|-------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 6.2 | The      Licensee hereby represents to the Licensor that it shall not, without the      prior written consent of theLicensor: |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------------|

|   | 6.2.1 | use      the Licensed Know-How and/or Licensed Patents for any purpose other than      the Approved Purpose; or |
|--------|-------|-----------------------------------------------------------------------------------------------------------------|

|   | 6.2.2 | Disclose      the Licensed Know-How to any Third Party for any purpose, except as      provided for in Clause 6.5; or |
|--------|-------|-----------------------------------------------------------------------------------------------------------------------|

|   | 6.2.3 | publish      the Licensed Know-How or otherwise place the Licensed Know-How in the      public domain; or |
|--------|-------|-----------------------------------------------------------------------------------------------------------|

|   | 6.2.4 | duplicate      the Licensed Know-How or produce extracts or documents containing Licensed      Know-How except for limited copies, extracts or documents made as needed      and provided on a need-to-knowbasis. |
|--------|-------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 6.3 | Furthermore,      the Licensee undertakes not to engage in or to procure the decompilation,      disassembly, or otherwise reverse engineering of any or all of the      Licensed Know-How and/or Licensed Patents, except and only to the extent      that such activity is expressly permitted by applicable law      notwithstanding this limitation.  The terms of this Clause 6.3      shall continue to apply notwithstanding termination of this TTL Agreement      or any other cessation of any business relationship between the      Parties. |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|  | 6.4 | The      Licensee shall limit access to the Licensed Know-How to those of its      employees, consultants and Permitted Sub-licensees who need to receive it      for the Approved Purpose and then only to the extent deemed      necessary.  The Licensee shall ensure that such employees,      consultants and Permitted Sub-licensees are made aware of its obligations      to maintain the Licensed Know-How in confidence and shall not Disclose      Licensed Know-How to any Third Party except as permitted by this TTL      Agreement. |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 6.5 | The      Licensee undertakes not to Disclose or permit to be Disclosed to any Third      Party other than to those of its officers, employees, agents, consultants,      licensees and financial investors that have a need to know the Licensed      Know-How of the Licensor for purposes of this Agreement, provided      that such Disclosure will be made under a confidentiality      non-Disclosure agreement comprising of terms at least as stringent as the      confidentiality provisions under this Clause 6.  Furthermore,      the Licensee will be entitled to Disclose the Process and the terms and      conditions of this Agreement to (i) potential licensees or collaboration      partners regarding the Product, and to (ii) potential acquirers of the      Licensee, provided,      however, that such potential sub-licensees, collaboration partners      or acquirers are in [***], that such Disclosure is necessary to evaluate      the respective project , that such potential sub-licensee or collaboration      partner is [***], based on [***], and is organised and operating in the      permitted territories listed in Schedule      D (but may not be disclosed to Affiliates outside these permitted      territories)  and that such Disclosure will be made under a      confidentiality non-Disclosure agreement comprising of terms at least as      stringent as the confidentiality provisions under this Clause      6.  With respect to any other potential sub-licensees,      collaboration partners and acquirers Disclosure can only be made upon the      Licensor's prior written consent, such consent not to be unreasonably      withheld or delayed.  For the avoidance of doubt, Licensee shall      remain fully liable for any disclosure by Licensee’s potential      sub-licensee, collaboration partner or acquirer of their respective      confidentiality obligations. |
|--|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 6.6 | The      foregoing restrictions on Disclosure and use shall not be applicable to      any Licensed Know-How which the Licensee can  demonstrate: |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 6.6.1 | was      rightfully in its possession prior to the date of    Disclosure; |
|--------|-------|---------------------------------------------------------------------------|

|   | 6.6.2 | was      in the public domain prior to the date of  Disclosure; |
|--------|-------|-----------------------------------------------------------------|

|   | 6.6.3 | has      subsequently entered into the public domain by publication or other means,      except by means of an unauthorised act or omission by the      Licensee; |
|--------|-------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 6.6.4 | was      supplied to the Licensee without restriction on use or Disclosure by a      Third Party who was under no restriction directly or indirectly to the      Licensor or any of its Affiliates regarding the use or Disclosure of said      information; |
|--------|-------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | 6.6.5 | that      the Licensee is required by law to Disclose, provided      that the Licensor is given prompt written notice of any such      requirement prior to any Disclosure of Licensed Know-How so that it may      contest such requirement, if necessary;or |
|--------|-------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 6.6.6 | was      independently developed by the Licensee or its Affiliates without access      to the Licensed Know-How and/or Licensed Patents, as evidenced by      documentary records. |
|--------|-------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a) | Licensed      Know-How contained within more general Information that may fall within      one or more of the exceptions; or |
|--------|-----|------------------------------------------------------------------------------------------------------------------------------|

|   | (b) | any      combination of features or items of Licensed Know-How where one or more of      the relevant individual features or items (but not the combination itself)      may fall within one or more of theexceptions. |
|--------|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 6.7 | The      non-disclosure and non-use provisions under this TTL Agreement shall      continue in force unless and until the Licensed Know-How enters the public      domain, other than through a breach of this TTL Agreement by the      Licensee. |
|--|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 6.8 | In      consideration of the Licensee receiving the Licensed Know-How and/or      Licensed Patents, the Licensee acknowledges that a breach of the      provisions of this TTL Agreement by the Licensee, or any of its employees      could result in serious damage being sustained by the Licensor and as a      result the Licensee hereby agrees: |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 6.8.1 | to      indemnify the Licensor fully for any losses, damages or expenses that may      be occasioned by any such breach;and |
|--------|-------|-----------------------------------------------------------------------------------------------------------------------------|

|   | 6.8.2 | that      since money damages alone may be a wholly inadequate measure of the loss,      the Licensor shall be entitled to specific enforcement of the terms hereof      (by injunction or otherwise) on such terms as any court with jurisdiction      may deem just and proper. |
|--------|-------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 7 | PAYMENTS |
|---|----------|

|   | 7.1 | In      the event the Process is based on the Lonza Process, as defined in the      Development Agreement, the Licensee shall pay within [***] after the first      regulatory approval of the Product in the United States, in the European      Union or in Japan a non-refundable and irrevocable disclosure fee in the      amount of |
|--------|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a) | £[***]      if the [***] of such Lonza Process isused, |
|--------|-----|-------------------------------------------------------------|

|   | (b) | £[***]      if the [***] of such Lonza Process isused, |
|--------|-----|-------------------------------------------------------------|

|   | (c) | no      additional payment if the [***] of such Lonza Process are being      used, |
|--------|-----|------------------------------------------------------------------------------------|

|   | provided,      however, that if [***], the Licensee shall only be required to pay      a pro-rata amount corresponding [***] , and further provided      that each of the payments under this Clause 7.1 shall only be made      once and the total payments shall in no event exceed      [***]. |
|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 7.2 | In      consideration of the rights granted under Clause 2 regarding the [***],      and upon termination of the Development Agreement (i.e., in the event the      Licensor does no longer develop and manufacture the Product on behalf of      the Licensee) the Licensee shall pay to the  Licensor: |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

*** Certain confidential information contained in this document,marked by brackets, has been omitted and filed separately with the Securitiesand Exchange Commission pursuant to Rule 24b-2 of the Securities Exchange Act of1934, as amended.

----

|  | (a) | within      [***] of the date of this TTL Agreement the sum of [***];    and |
|--|-----|------------------------------------------------------------------------------|

|  | (b) | a      royalty of [***] on a country-by-country basis of the Net Selling Price of      each Product sold in the Territory by the Licensee (or its sublicensee),      such royalty being payable for as long as the manufacture, use or sale of      the Product (or any other infringing act) is covered under a Valid Claim      within the [***] (with the exception only of Improvements assigned to      Licensor under Clause 5 above);or |
|--|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | provided,      however, that regarding [***] the following shall apply: although [***] is      not covered by a Valid Claim, the Parties have agreed to link the duration      of royalty payments to a Valid Claim, and Licensee shall pay as follows: a      royalty of [***] on a country-by-country basis of the Net Selling Price of      each Product sold in the Territory by the Licensee (or its sublicensee),      for as long as royalties under Clause 7.2 would be payable as if the      Product was covered under a Valid Claim of the patent in Schedule B      hereto; and |
|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | and      that regarding [***] the following shall apply: in the event of no Valid      Claim within [***] subsisting on the Effective Date; a royalty of [***] of      the Net Selling Price of each Product sold in the Territory by the      Licensee (or its sublicensee), for a period of [***] post first commercial      sale of the Product. |
|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 7.3 | To      the extent the Licensee requires a license to any Licensed Patents and/or      Licensed Know-How which is generated by the Licensor during the term of      this TTL Agreement, the Parties shall agree in good faith on any      reasonable consideration for such license, if  any. |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 7.4 | The      Licensee shall keep true and accurate records and books of account      containing all data necessary for the calculation of royalties payable to      the Licensee under Clause 7.2 above.  Such records and books of      account shall, upon reasonable notice having been given by the Licensor      (which in no event shall be less than [***] prior notice), be open at all      reasonable times during regular business hours for inspection by      independent, certified and internationally recognized auditors selected by      the Licensor and reasonably acceptable to the Licensee.  Such      independent auditors shall agree to maintain the confidentiality of the      information and materials disclosed during the audit.  Any such      audit shall be conducted during regular business hours, in a manner that      does not interfere unreasonably with the operations of the Licensee’s      business and, save for cause, not more often than once every calendar      year.  Each audit shall begin upon reasonable prior written      notice to the Licensor and shall be completed as soon as reasonably      practicable.  The Licensor shall pay the costs of the      independent auditors conducting such audit, unless the results of the      audit reveal an underpayment of [***] or more by the Licensee, in which      case, the Licensee shall pay the reasonable costs of the independent      auditors.  If an audit concludes that an overpayment or      underpayment has occurred during the audited period, such payment shall be      remitted by the Party responsible for such payment to the other Party      within [***] after the date such auditor’s written report identifying the      overpayment or underpayment is delivered to the Party responsible for such      payment. |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|  | 7.5 | The      Licensee shall prepare a statement in respect of each calendar quarter      which shall show for the immediately preceding quarter details of the      sales of Product and the royalty due and payable to the Licensor      thereon.  Such statement shall be submitted to the Licensor      within [***] after the end of the calendar quarter to which it relates,      together with a remittance for the royalties due to the      Licensor. |
|--|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 7.6 | All      sums due under this TTLAgreement: |
|--------|-----|--------------------------------------------|

|   | 7.6.1 | shall      be made in pounds sterling to the Licensor.  Payments due to the      Licensor in currencies other than pounds sterling shall first be      calculated in the relevant local currency before being calculated at the      rate of exchange in effect at the close of business on the day payment is      due or made, whichever is earlier, provided      always that where payment is made after the date provided therefore      herein conversion shall be at the rate in effect at the date of payment if      this is more favourable to the Licensor.  The rate of exchange      shall be the mean value of the Pound Spot Rate in London first published      in the Financial Times on the day following the day for determining such      rates; |
|--------|-------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 7.6.2 | are      exclusive of any Value Added Tax or of any other applicable taxes, levies,      imposts, duties and fees of whatever nature imposed by or under the      authority of any government or public authority, and shall be paid by the      Licensee (other than taxes on the Licensor’s income).  The      Parties agree to co-operate in all respects reasonably necessary to take      advantage of such double taxation treaties as may be      available. |
|--------|-------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 7.7 | In      the event of any delay in effecting payment due under this TTL Agreement      by the due date, the Licensee shall pay to the Licensor interest      calculated on a daily basis on the overdue payment, from the date after      such payment was due to the date of actual payment, at a rate of      [***]. |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 8 | PROTECTION      OF THE LICENSED KNOW-HOW |
|---|------------------------------------------|

|  | 8.1 | In      the event that any unlicensed activities are carried on by any Third Party      which could constitute unauthorised Disclosure or the misuse of any of the      Licensed Know-How, the Party becoming aware of such a matter shall      immediately notify the other of it, and the Licensee shall join the      Licensor in taking all steps (if any) as, in the total discretion of the      Licensor, shall be desirable for the protection of the Licensor's rights      under the Licensed Know-How.  The expenses incurred in taking      such steps, and any profits or damages which may be obtained, shall be (in      the absence of any agreement to the contrary) for the account of the      Licensor. |
|--|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|  | 8.2 | Subject      only to Clause 9 below, nothing in this TTL Agreement shall constitute any      representation that the Products or the use of the Licensed Know-How does      not fall within the scope of any Third Party Intellectual      Property. |
|--|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9 | WARRANTIES      AND INDEMNITIES |
|---|---------------------------------|

|  | 9.1 | Each      of the Parties warrants that it has full power and authority to carry out      the actions contemplated under this TTL Agreement, and that its entry into      and performance under the terms of this TTL Agreement will not infringe      the rights of any Third Party or cause it to be in breach of any      obligations to a Third Party. |
|--|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 9.2 | The      Licensor warrants to the Licenseethat: |
|--|-----|-------------------------------------------------|

|   | 9.2.1 | all      Information, data and materials provided by it to the Licensee hereunder      will be, to the best of its knowledge, accurate and complete in all      material respects, and it is entitled to provide the same to the Licensee      without recourse to any Third Party;and |
|--------|-------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 9.2.2 | to      the best of its knowledge and belief, the Information, the Licensed      Know-How, the Licensed Patents and/or the [***] do not infringe, the      rights of any Third Party, and no Third Party has threatened or, so far as      it is aware, is currently threatening proceedings in respect of such      infringement, and none of its Information, the Licensed Know-How, the      Licensed Patents and/or the [***] is the subject of any actual or, so far      as it is aware, threatened challenge or opposition or revocation      proceedings; and |
|--|-------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 9.2.3 | to      the best of its knowledge and belief, the [***] if used per the      instructions provided by the Licensor is suitable for the Approved      Purpose.  If during the term of this TTL Agreement Licensor      learns that the [***] is not suitable for the Approved Purpose or causes      adverse effects, the Licensor shall promptly inform the Licensee hereof;      and |
|--|-------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 9.2.4 | to      the best of its knowledge and belief, the suppliers of [***] and [***]      will be able and willing to supply such [***] to the Licensee or its      sublicensee or Third Party contract manufacturer of Licensee or      sublicensee for the manufacture of the Product for clinical and commercial      supply at terms and conditions of supply customary in the      industry. |
|--|-------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|  | 9.3 | Each Party (“Indemnifying Party”) shall defend, indemnify and hold      harmless the other Party (“Indemnified Party”) and its directors, officers, employees      and agents and the successors and assigns of any of the foregoing at all      times from and against any Third Party claims actions, liabilities, costs      and expenses (including court costs and legal fees on a full indemnity      basis) that the Indemnified Party may suffer arising directly out of the      Indemnifying Party’s breach of this TTL Agreement, including breach of      representations and warranties, violation of applicable law, or the      Indemnifying Party's negligent or wilful act or      omission. |
|--|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 9.4 | With      respect to liability claims or proceedings, the following shall apply; (a)      except to the extent provided in (b) below, the Licensee shall indemnify      and hold harmless the Licensor and its directors, officers, employees and      agents and the successors and assigns of any of the foregoing at all times      from any against any Third Party claims, actions, liabilities, costs and      expenses (including court costs and legal fees on a full indemnity basis)      that the Indemnified Party may suffer as a direct result of any tortious      claims or proceedings of death or bodily injury relating to the Product      and this TTL Agreement, and (b) the Licensor shall indemnify and hold      harmless the Licensee and its directors, officers, employees and agents      and the successors and assigns of any of the foregoing at all times from      any against any Third Party claims, actions, liabilities, costs and      expenses (including court costs and legal fees on a full indemnity basis)      that the Indemnified Party may suffer as a direct result of any tortious      claims or proceedings of death or bodily injury relating to the Product to      the extent such claims or proceedings result from defects in the      Information, the Licensed Know-How or the Licensed Patents, or from      Licensor's breach of this TTLAgreement. |
|--|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 9.5 | If      an Indemnified Party intends to claim indemnification under this Clause 9,      it shall promptly notify the Indemnifying Party in writing of such alleged      liability.  The Indemnifying Party shall have the right to      control the defence thereof with counsel of its choice as long as such      counsel is reasonably acceptable to Indemnified Party; provided,      however, that      the Indemnified Party shall have the right to retain its own      counsel at its own expense, for any reason, including if representation of      the Indemnified Party by the counsel retained by the Indemnifying would be      inappropriate due to actual or potential differing interests between such      Indemnified Party and any the Indemnifying Party.  The      Indemnified Party, its employees and agents, shall reasonably cooperate      with the Indemnifying Party and its legal representatives in the      investigation of any liability covered by this Clause 9.  The      obligations of this Clause 9 shall not apply to amounts paid in settlement      of any claim, demand, action or other proceeding if such settlement is      effected without the consent of the Indemnifying Party, which consent      shall not be withheld or delayed unreasonably.  The failure to      deliver written notice to the Indemnifying Party within a reasonable time      after the commencement of any such action, if prejudicial to its ability      to defend such action, shall relieve the Indemnifying Party of any      obligation to the Indemnified Party under this Clause 9.  It is      understood that only the Licensor and the Licensee may claim indemnity      under this Clause 9 (on its own behalf or on behalf of its indemnitees),      and other indemnitees may not directly claim indemnity      hereunder. |
|--|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|  | 9.6 | Any      condition or warranty other than those set forth in Clause 9.2 and/or      relating to title which might otherwise be implied or incorporated within      this TTL Agreement by reason of statute or common law or otherwise is      hereby expressly excluded. |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 9.7 | IN      NO EVENT (OTHER THAN WILFUL MISCONDUCT) SHALL EITHER PARTY BE LIABLE TO      THE OTHER PARTY FOR LOSS OF PROFITS, SPECIAL, INDIRECT, INCIDENTAL,      PUNITIVE OR CONSEQUENTIAL DAMAGES ARISING OUT OF THIS TTL      AGREEMENT. |
|--|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10 | DURATION      AND TERMINATION |
|----|-------------------------------|

|  | 10.1 | This      TTL Agreement shall come into force on the Effective Date of this TTL      Agreement and shall, unless terminated in accordance with Clause 10.2 or      10.3 below, remain in force until the Licensee has no further need to use      the Information, the Licensed Know-How, the Licensed Patents and/or the      [***]. |
|--|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 10.2 | The      Licensee shall be entitled to terminate this TTL Agreement at any time by      giving [***] prior written notice. |
|--|------|----------------------------------------------------------------------------------------------------------------------------|

|  | 10.3 | The      Licensor shall have the right to terminate this TTL Agreement immediately      by notice in writing to theLicensee: |
|--|------|------------------------------------------------------------------------------------------------------------------------------|

|   | (i) | in      the event that the Licensee fails to perform or observe any of the      obligations on its part to be performed or observed under this TTL      Agreement, provided, that, in a case where the breach is remediable, such      notice from the Licensor shall also require the Licensee to remedy such      breach and if the Licensee so remedies within [***], in the event of a      breach of [***], and within [***], in the event of any other breach, of      such notice being served, such notice to terminate this TTL Agreement      shall be deemed to be void and of no effect;or |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (ii) | in the event an interim order is applied for      or made, or a voluntary arrangement approved, or a petition for a      bankruptcy order is presented or a bankruptcy order is made against the      Licensee, or a receiver or trustee in bankruptcy is appointed of the      Licensee's estate or a voluntary arrangement is proposed or approved or an      administration order is made, or a receiver or administrative receiver is      appointed of any of the Licensee's assets or undertaking, or a winding-up      resolution or petition is passed or presented (otherwise than for the      purposes of reconstruction or amalgamation), or any circumstances arise      which entitle the court, a creditor, the company or its directors to      appoint a receiver, administrative receiver or administrator or to present      a winding-up petition or make a winding-up order or other similar or      equivalent action is taken against or by the Licensee by reason of its      insolvency or in consequence of debt, and      provided that following such proceedings the Licensee is Controlled      by companies, partnerships and/or other entities which are registered and      operating, with respect to the manufacturing of the Product, outside the      permitted territories listed in Schedule      D. |
|--------|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|  | 10.4 | Upon      termination of this Agreement in accordance with Clause 10.3 (i), the      Licensee shall offer to each sublicensee and/or sub-sublicensee a direct      license agreement on substantially the same the terms and conditions as      this TTL Agreement, provided,      however, that the Licensor is not required to grant such direct      licence if the sublicensee is in breach of its sublicense agreement at the      time such direct licence is to begranted. |
|--|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 10.5 | In      the event of expiry or termination of this TTL Agreement for any reason,      and subject to any express provisions set out elsewhere in this TTL      Agreement: |
|--|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 10.5.1 | all      rights and licences shallcease; |
|--|--------|------------------------------------------|

|   | 10.5.2 | the      Licensee shall cease all exploitation of the Licensed Know-How and/or      Licensed Patents and any other know-how provided by the Licensor to the      Licensee, except insofar as the Licensed Know-How, or such other know-how,      ceases or has ceased to be confidential, unless this is or was as a      consequence of the default of theLicensee; |
|--------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 10.5.3 | the      Licensee shall return promptly to the Licensor all technical material in      its possession relating to the Information, the Licensed Know-How and/or      the Licensed Patents and all copies of such material to the extent that      such material remainsconfidential; |
|--|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 10.5.4 | the      Licensee shall have the right to dispose of all stocks of the Product in      its possession and all Product in the course of manufacture at the date of      termination; and |
|--|--------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 10.5.5 | irretrievably      delete any Licensed Know-How, stored on any magnetic or optical disk or      memory and all matter derived from such sources which is in its possession      or under its control. |
|--|--------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 10.6 | The      expiry or termination of this Agreement for any reason shall be without      prejudice to the provisions of this Clause 10 and to any rights of either      Party which may have accrued by, at or up to the date of such      termination. |
|--|------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 11 | ASSIGNMENT |
|----|------------|

----

| 12 | SEVERANCE |
|----|-----------|

| 13 | NO      WAIVER |
|----|----------------|

| 14 | VARIATION |
|----|-----------|

| 15 | FURTHER      ASSURANCE |
|----|------------------------|

| 16 | ENTIRE      AGREEMENT; SURVIVAL |
|----|---------------------------------|

|  | 16.1 | This      TTL Agreement and the documents referred to in it, constitute the entire      agreement and understanding of the Parties and upon the Effective Date of      this TTL Agreement supersede any previous agreement between the Parties      relating to the subject matter of this TTL Agreement.  For the      avoidance of doubt, the [***] dated [***] shall not apply to the      manufacture of the Product. |
|--|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 16.2 | Each      of the Parties acknowledges and agrees that, in entering into this TTL      Agreement and the documents referred to in it, it does not rely on, and      shall have no remedy in respect of, any statement, representation,      warranty or understanding (whether negligently or innocently made) of any      person (whether party to this TTL Agreement or not) other than as      expressly set out in this TTL Agreement as a warranty or      representation.  The only remedy available to it for breach of      such warranties or representations shall be for breach of contract under      the terms of this TTL Agreement.  Nothing in this clause shall      operate to limit or exclude any liability for  fraud. |
|--|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | 16.3 | The      obligations of the Parties under Clauses 4 (The Licensee's Obligations), 5      (Improvements), 6 (Confidentiality), 9 (Warranties and Indemnities) and      10.4 (consequences of termination) shall survive the termination of this      Agreement for any reason. |
|--|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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| 17 | NOTICE |
|----|--------|

|  | 17.1 | Any      notice or other communication to be given under this TTL Agreement shall      be delivered personally or sent by facsimile transmission, or if facsimile      transmission is not available, by first class pre-paid post addressed as      follows: |
|--|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (a)    | If      to Lonza to:             | Lonza      Sales AGMuenchensteinerstrasse      38CH-4402      BaselSwitzerlandFacsimile:      +41 61 316 8329Attention:  The      Head of Legal Services |
|--------|--------|----------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   |   |                             |                                                                                                                                                               |
|   |   | with      a copy to:             | Lonza      Biologics plc228      Bath RoadSloughBerkshire      SL1 4DXEngland                                                                                      |
|   |   | Facsimile:                  | +44      1753 777001                                                                                                                                               |
|   |   | For      the attention of:  | The      Head of Legal Services                                                                                                                                    |
|   |   |                             |                                                                                                                                                               |
|   | (b)    | If      to Micromet to:          | Micromet      AGStaffelseestrasse      2D-81477      MunichGermany                                                                                                 |
|   |   | Facsimile:                       | +49-89-895      277 205                                                                                                                                            |
|   |   | For      the attention of:       | Head      of Business Development                                                                                                                                  |
|   |   |                             |                                                                                                                                                               |
|   |   | with      a copy to:             | Micromet,      Inc.6707      Democracy BoulevardSuite      505Bethesda,      MD 20817United      States of America                                                 |
|   |   | Attention:                       | General      Counsel                                                                                                                                               |
|   |   | Facsimile:                       | +1      240 752-1425                                                                                                                                               |

|   | or      to such other destination as either Party hereto may hereafter notify to      the other in accordance with the provisions of this Clause    17. |
|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 17.2 | All      such notices or other communications shall be deemed to have been served      as follows: |
|--------|------|----------------------------------------------------------------------------------------------------|

|   | (a)  | if      delivered personally, at the time of such  delivery; |
|--------|-----------|--------------------------------------------------------------|

|   | (b) | if      sent by facsimile, upon receipt of the transmission confirmation slip      showing completion of thetransmission; |
|--------|-----|---------------------------------------------------------------------------------------------------------------------------|

|   | (c) | if      sent by first class pre-paid post, ten (10) business days (Saturdays,      Sundays and Bank or other public holidays excluded) after being placed in      the post. |
|--------|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 18 | GOVERNING      LAW, DISPUTE RESOLUTION |
|----|----------------------------------------|

|   | 18.1 | The      construction, validity and performance of the TTL Agreement shall be      governed by the laws ofSwitzerland. |
|--------|------|------------------------------------------------------------------------------------------------------------------------|

|   | 18.2 | No      failure or delay on the part of either Licensor or Licensee to exercise or      enforce any rights conferred on it by this TTL Agreement shall be      construed or operate as a waiver thereof nor shall any single or partial      exercise of any right, power or privilege or further exercise thereof      operate so as to bar the exercise or enforcement thereof at any time or      times thereafter. |
|--------|------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | 18.3 | Any      disputes relating to issues arising from this TTL Agreement shall, in the      absence of resolution within [***] of the dispute arising, be referred to      the CEOs of Licensee and COO of Licensor, who shall discuss the matter and      attempt to resolve it by mutual consent.  The CEOs of Licensee      and COO of Licensor shall meet once face-to-face within [***] to discuss      and resolve the dispute.  If the dispute cannot be resolved      within [***], either Party may, by written notice to the other Party,      invoke the mediation procedure set out in Clause 18.4    below. |
|--------|------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 18.4 | If      a dispute arises between the Parties that the Parties cannot resolve      pursuant to Clause 18.3 above, the Parties agree to try to solve such      dispute amicably by mediation.  The Parties shall conduct a      mediation procedure according to the ICC ADR Rules of the International      Chamber of Commerce (ICC) in effect on the date of the commencement of the      mediation proceedings.  The location of the mediation      proceedings will be Basel.  The number of mediators will be one      (1).  The language of the mediation proceeding will be      English.  If the dispute has not been settled pursuant to the      said rules within [***] following the filing of a request for mediation or      within such other period as the Parties may agree in writing, either Party      may submit the dispute to final and binding arbitration.  |
|--------|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 18.5 | Any      dispute relating to the validity, performance, construction or      interpretation of this TTL Agreement, which cannot be resolved amicably      between the Parties, shall be submitted to arbitration in accordance with      the ICC Arbitration Rules of the International Chamber of      Commerce.  Save in the face of manifest error, the decision of      the arbitrators shall be final and binding upon the Parties and      enforceable in any court of competent jurisdiction.  The      location of arbitration will be Basel.  The arbitration will be      heard and determined by one (1) arbitrator, who will be jointly selected      by Licensor and Licensee.  If, within [***] following the date      upon which a claim is received by the respondent, the Parties cannot agree      on a single arbitrator, the arbitration will be heard and determined by      three (3) arbitrators, with one arbitrator being appointed by each Party      and the third arbitrator being selected by the two Party-appointed      arbitrators.  If either Party fails to select an arbitrator, or      if the Party-appointed arbitrators cannot agree on a third arbitrator      within [***] of the respondent receiving the claim, such arbitrator will      be appointed by the International Court of Arbitration according to the      ICC Rules.  The arbitration award that is consistent with the      provisions of this TTL Agreement that is so given will be binding upon the      Parties, accompanied by a reasoned opinion in writing (in English), and      the judgment on the award may be entered in any court having competent      jurisdiction thereof.  |
|--------|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 18.6 | Each      Party will bear its own costs and expenses (including its attorney’s fees)      associated with any arbitration initiated under this Clause, and each      Party will bear an equal share of the arbitrators’ and administrative fees      associated with any arbitration initiated under this      Clause.  The language of the arbitration proceeding will be      English.  Notwithstanding the foregoing, Parties agree that the      non-prevailing Party shall reimburse the costs of the prevailing      Party.  |
|--------|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | 18.7 | Notwithstanding      the provisions of Clause 18.5, each Party shall have the right to seek,      without proof of special damage, a preliminary, permanent injunctive or      other equitable relief in any court of competent jurisdiction as such      Party deems necessary to preserve its rights and to protect its      interests. |
|--------|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 19     | RIGHTS      OF THIRD PARTIES                                                                                                                                                                                                         |
|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|   |                                                                                                                                                                                                                                 |
|   | Parties      intend that no term of this TTL Agreement shall be enforceable by any      Third Party, but this does not affect any right or remedy of a Third Party      which exists or is available under the laws of  Switzerland. |

| Signed      by                                |   |
|-----------------------------------------------|--------|
| for      and on behalf of LONZA      SALES AG |   |
|                                          |   |
| Signed      by                                |   |
| for      and on behalf of LONZA      SALES AG |   |

----

| Signed      by                             |   |
|--------------------------------------------|--------|
| for      and on behalf of MICROMET      AG |   |
|                                       |   |
| Signed      by                             |   |
| for      and on behalf of MICROMET      AG |   |

----

----

----

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|   | · | [***]                         |
|--------|--------|-------------------------------|
|   | · | USA                      |
|   | · | EU,      EFTA and Switzerland |
|   | · | Japan     |
|   | · | Australia                     |
|   | · | New      Zealand              |
|   | · | Canada                        |

| Contract      Manufacturing Organization(and      their Affiliates in the permitted territorieslisted      above) |   | Company      Details |
|-------------------------------------------------------------------------------------------------------------------|--------|----------------------|
| [***]                                                                                                             |   | [***]                |
| [***]                                                                                                             |   | [***]                |
| [***]                                                                                                             |   | [***]                |
| [***]                                                                                                             |   | [***]                |
| [***]                                                                                                             |   | [***]                |
| [***]                                                                                                             |   | [***]                |
| [***]                                                                                                             |   | [***]                |
| [***]                                                                                                             |   | [***]                |

----

----

| Lonza      Group Ltd               | Lonza      Group Ltd     | Lonza      Group Ltd     |
|------------------------------------|--------------------------|--------------------------|
| Head      Corporate Communications | Media      Relations     | Investor      Relations  |
| Michael      Frizberg              | Dominik      Werner      | Dirk      Oehlers        |
| Tel      +41 61 316 8624           | Tel      +41 61 316 8798 | Tel      +41 61 316 8540 |
| Fax      +41 61 316 9624           | Fax      +41 61 316 9798 | Fax      +41 61 316 9540 |
| michael.frizberg@lonza.com         | dominik.werner@lonza.com | dirk.oehlers@lonza.com   |

----

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| US      Media:                   | European      Media:     |
|----------------------------------|--------------------------|
| Andrea      tenBroek/Chris Stamm | Ludger      Wess         |
| (781)-684-0770                   | +49      (40) 8816 5964  |
| micromet@schwartz-pr.com         | ludger@akampion.com      |
|                             |                     |
| US      Investors:               | European      Investors: |
| Susan      Noonan                | Ines-Regina      Buth    |
| (212)      966-3650              | +49      (30) 2363 2768  |
| susan@sanoonan.com               | ines@akampion.com        |

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