---

EXHIBIT 12.1  CERTIFICATION OF CEO PURSUANT TO SECTION
302

CERTIFICATION

I, Albert D. Friesen, certify that:

1. I have reviewed this annual report
on Form 20-F of Medicure Inc.;

2. Based on my knowledge, this
report does not contain any untrue statement of a material fact or omit to state
a material fact necessary to make the statements made, in light of the
circumstances under which such statements were made, not misleading with respect
to the period covered by this report;

3. Based on my knowledge, the
financial statements, and other financial information included in this report,
fairly present in all material respects the financial condition, results of
operations and cash flows of the company as of, and for, the periods presented
in this report;

4. The company's other certifying
officer(s) and I are responsible for establishing and maintaining disclosure
controls and procedures (as defined in Exchange Act Rules 13a-15(e) and
15d-15(e)) and internal control over financial reporting (as defined in Exchange
Act Rules 13a-15(f) and 15(d)-(15)(f)) for the company and have:

| | (a) | Designed such disclosure controls and procedures, or
      caused such disclosure controls and procedures to be designed under our
      supervision, to ensure that material information relating to the company,
      including its consolidated subsidiaries, is made known to us by others
      within those entities, particularly during the period in which this report
      is being prepared;
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |     |                                                                                                                                                                                                                                                                                                                                                                                                          
| | (b) | Designed such internal control over financial reporting,
      or caused such internal control over financial reporting to be designed
      under our supervision, to provide reasonable assurance regarding the
      reliability of financial reporting and the preparation of financial
      statements for external purposes in accordance with generally accepted
      accounting principles;    
| |     |                                                                                                                                                                                                                                                                                                                                                                                                          
| | (c) | Evaluated the effectiveness of the company's disclosure
      controls and procedures and presented in this report our conclusions about
      the effectiveness of the disclosure controls and procedures, as of the end
      of the period covered by this report based on such evaluation;
  and                                                                                                     
| |     |                                                                                                                                                                                                                                                                                                                                                                                                          
| | (d) | Disclosed in this report any change in the company's
      internal control over financial reporting that occurred during the period
      covered by the annual report that has materially affected, or is
      reasonably likely to materially affect, the company's internal control
      over financial reporting; and                                                                             

5. The company's other certifying
officer(s) and I have disclosed, based on our most recent evaluation of internal
control over financial reporting, to the company's auditors and the audit
committee of the company's board of directors (or persons performing the
equivalent functions):

| | (a) | All significant deficiencies and material weaknesses in
      the design or operation of internal control over financial reporting which
      are reasonably likely to adversely affect the company's ability to record,
      process, summarize and report financial information; and
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
| |     |                                                                                                                                                                                                                                                                                         
| | (b) | Any fraud, whether or not material, that involves
      management or other employees who have a significant role in the company's
      internal control over financial reporting.                                                                                                     

|Date: September 28, 2010 | /s/ Albert Friesen           
|------------------------ | -----------------------------
|                         |                              
|                         | Chief Executive Officer      
|                         | (Principal Executive Officer)

---