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EMPLOYMENT AGREEMENT

THIS AGREEMENT made the 1st day of October, 2001.

BETWEEN:

MEDICURE INC., 
  a corporation incorporated under the federal laws of Canada,
  (hereinafter referred to as the "Employer"),

- and -

DAWSON REIMER,
  of the City of Winnipeg, in the Province of Manitoba,
  (hereinafter referred to the "Employee").

WHEREAS
  the Employer is engaged in the Business;

AND
  WHEREAS the Employer desires to employ or to continue to employ the Employee
  in its Business, and the Employee desires to be so employed or to be so continued
  to be employed;

NOW
  THEREFORE in consideration of the premises and of the mutual covenants herein
  contained, the parties hereto agree as follows:

1.
  Definitions

Capitalized
  terms used in this Agreement shall have the meanings set forth in Schedule A
  hereto.

2. 
  Employment

The
  Employer hereby agrees to employ the Employee for the purpose set forth in Schedule
  B attached hereto, and the Employee hereby accepts such employment, all on the
  terms and conditions herein set forth.

|3. Commencement
      and Termination
|-------------------------------------
|                                     
|                                     

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2

| | (b) | Either party may terminate this Agreement
        at any time, without cause, on two weeks written notice to the other party
        or, in the case of termination by the Employer, payment of the Employee's
        salary for two weeks in lieu of such notice. The Employer may terminate
        this Agreement at any time for cause immediately upon notifying the Employee
        in writing to this effect. For purposes of this Agreement, "cause" shall
        include any breach of this Agreement by the Employee, receipt by the Employer
        of notice from any client or customer of the Employer that the performance
        of the Employee is unsuitable, or, subject to the Employer's duty to reasonably
        attempt to accommodate the Employee, in the event the Employee becomes
        "totally disabled". For certainty, "totally disabled" means the occurrence
        of:
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|
| |     | (i)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                
|
| |     | (ii)                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                               
|
| | (c) | Notwithstanding paragraph (b) of this
        section 3, in the event the Employee has not already been employed by
        the Employer for at least three months, the first three months of employment
        under this Agreement shall be considered a probationary period, during
        which period such employment may be terminated by the Employer without
        notice and without payment in lieu of notice if the Employee's services
        are not satisfactory to the Employer.                                                                                                                                                                                                                                                                                                                                                                                                               
|
| | (d) | In the event the Employee seeks to terminate
        this Agreement but does not provide two weeks notice as required by paragraph
        (b) of this section 3, the Employer may recover an equivalent amount from
        the Employee in lieu of such notice by set off against any and all amounts
        then owing by the Employer to the Employee including, without limitation,
        vacation pay.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                    
|
| | (e) | In the event of any termination of employment
        under this Agreement for any reason whatsoever, the Employee acknowledges
        and agrees that the Employee will have no claim against the Employer for
        damages or otherwise except for accrued remuneration due and owing to
        the Employee as of the effective date of such termination.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                  

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| | (f) | Notwithstanding any other provision of this section
        3, this Agreement shall terminate immediately upon any termination of
        any contract which the Employer has entered into and which is referred
        to in Schedule B.                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                       
| | --- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|
| | (g) | In the event of any termination of employment under
        this Agreement for any reason whatsoever, or upon the request of the Employer
        from time to time, the Employee shall immediately return to the Employer
        all materials, including all copies in whatever form, containing any Confidential
        Information which are in the Employee's possession or under the Employee's
        control, together with anything else that could provide access to any
        Confidential Information as well as all records or personal notes of any
        nature whatsoever prepared by the Employee and relating to work performed
        by the Employee while employed by the Employer, including all copies in
        whatever form as well as all other property of the Employer then in the
        possession or under the control of the Employee including, without limitation,
        all computer equipment (hardware, software, and documentation), all other
        equipment, all tools, all materials, all merchandise, and all promotional
        information of any nature whatsoever.

4. 
  Compensation

The
  Employee's compensation shall be the amount calculated and paid in the manner
  set forth in Schedule B.

5. 
  General Duties

During
  the period of employment of the Employee by the Employer, the Employee shall:

| | (a) | devote full working time and best efforts, judgment,
        skill, and ability to the performance of all duties as may be assigned
        to the Employee by the Employer, from time to time;                                                                                                                                                                                                           
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|
| | (b) | comply with all lawful instructions of the Employer
        as may be in effect from time to time, and abide by any and all rules,
        policies, and procedures enacted by the Employer and brought to the attention
        of the Employee as same may be in effect from time to time including,
        without limitation, those regarding attendance, professional conduct,
        and security;
|
| | (c) | reflect the highest standards of integrity, honesty,
        and responsibility in dealings with the Employer's or its Affiliates'
        clients, prospective clients, customers, prospective customers, suppliers,
        and employees; and                                                                                                                                                          
|
| | (d) | use his best efforts to faithfully, honestly, and
        diligently serve and endeavour to further the best interests of the Employer.                                                                                                                                                                                                                                                                   

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6. 
  Confidential Information

The
  Employee acknowledges that during the course of employment with the Employer
  the Employee may become aware of, see or receive copies of, have access to or
  become knowledgeable in respect of Confidential Information. The Employee acknowledges
  and agrees that the Employee shall not acquire any right, title or interest
  in or to any Confidential Information, by virtue of being employed by the Employer
  or otherwise, and that the Employer or its Affiliates, clients, customers or
  suppliers, as the case may be, owns the Confidential Information.

7.
  Non-Disclosure of Confidential Information

At
  all times during the Employee's employment with the Employer and at all times
  subsequent thereto, the Employee shall:

| | (a) | keep in strictest confidence and trust all Confidential
        Information;                                                                                    
| | --- | ----------------------------------------------------------------------------------------------------------------------------------------------------------------
|
| | (b) | take all necessary precautions against unauthorized
        disclosure of any Confidential Information;                                                         
|
| | (c) | not directly or indirectly disclose, allow access
        to, transmit or transfer any Confidential Information to a third party;
        and                   
|
| | (d) | not copy or reproduce any Confidential Information
        except as may be reasonably required for the Employee to perform his duties
        for the Employer.

For
  certainty, at all times during the Employee's employment with the Employer and
  all times subsequent thereto, the Employee acknowledges that he shall not disclose
  or use any Confidential Information in any manner whatsoever except as reasonably
  required for the Employee to perform his duties for the Employer.

8.
  Developments

The
  Employee agrees to be bound by the Employer's Developments Policy as set forth
  in Schedule C to this Agreement.

9. 
  Non-Competition

The
  Employee agrees that while the Employee is employed by the Employer, and for
  a period of one (1) year immediately following the termination of the Employee's
  employment with the Employer for any reason whatsoever, without the prior written
  approval of the President of the Employer, the Employee shall not, either individually
  or in partnership or in conjunction with any person, firm, association, syndicate,
  corporation or entity as principal, agent, shareholder, employee, owner, investor,
  partner (inactive or otherwise), director or officer of a corporation or in
  any other manner whatsoever, directly or indirectly, carry on or be engaged

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in or be concerned with or interested in or advised, to lend
  money to, and guarantee the debts or obligations of or permit his name or any
  part thereof to be used or employed by any person, firm, association, syndicate,
  corporation or entity engaged in or concerned with or interested in, within
  North America, the Business, or any business similar to the Business carried
  on by the Employer or any Affiliate, or that could reasonably be viewed as being
  competitive with the Business of the Employer or any Affiliate.

The
  Employee hereby agrees that all restrictions in this section 9 are reasonable
  and valid and all defences to the strict enforcement thereof by the Employer
  are hereby waived by the Employee.

10. Non-solicitation

The
  Employee agrees that while the Employee is employed by the Employer, and for
  one (1) year immediately following the termination of the Employee's employment
  with the Employer for any reason whatsoever, the Employee shall not, without
  the prior written consent of the Employer, directly or indirectly, either personally
  or by agent or by letters, circulars or advertisements, whether on his own behalf
  or on behalf of any other person, firm, association, syndicate, corporation
  or entity:

| | (a) | contact, canvass, solicit, induce or attempt to
        induce or do business of a similar nature as that of the Employer, with
        any person, firm, association, syndicate, corporation, or entity which
        was a client, customer, employee of or an independent contractor to the
        Employer or any Affiliate at the time of such termination or any time
        during the twelve (12) month period immediately preceding such termination;                                                         
| | --- | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|
| | (b) | hire any employee of or independent contractor to
        the Employer or any Affiliate, or contact, canvass, solicit, induce or
        attempt to induce any person who was an employee of or an independent
        contractor to the Employer or any Affiliate at the time of such termination
        or any time during the twelve (12) month period immediately preceding
        such termination, to terminate their employment or independent contracting
        agreement with the Employer or any Affiliate.

The
  Employee hereby agrees that all restrictions in this section 10 are reasonable
  and valid and all defences to the strict enforcement thereof by the Employer
  are hereby waived by the Employee.

11.
  Security Clearance Requirements

The
  Employee shall forthwith comply with each and every security clearance requirement
  communicated by the Employer to the Employee. In particular, the Employee acknowledges
  and agrees that continued employment by the Employer may be conditional upon
  the Employee complying with such security clearance requirements.

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12. Enforcement

The
  Employee acknowledges and agrees that the Employee's faithful observance of
  all covenants in this Agreement is an essential condition to his employment,
  and that the Employer requires absolute compliance. The Employee further acknowledges
  and agrees that damages may not be an adequate remedy to compensate the Employer
  for any breach of the Employee's obligations contained in this Agreement, and
  accordingly the Employee agrees that in addition to any and all other remedies
  available, the Employer shall be entitled to obtain relief by way of a temporary
  or permanent injunction to enforce the obligations contained in this Agreement.
  The Employee further acknowledges and agrees that any breach of this Agreement,
  including, without limitation, the Employer's Technology Protection Policy,
  if any, in effect from time to time, shall constitute grounds for discipline
  up to and including immediate termination of employment for cause.

13.  Entire
  Agreement


This
  Agreement, together with any schedule which may be attached hereto from time
  to time, constitutes the entire agreement between the Employer and the Employee
  pertaining to the subject matter hereof and supercedes all prior formal and
  informal agreements, proposals, promises, inducements, representations, conditions,
  warranties, understandings, negotiations, and discussions, whether oral or written,
  of the Employer and the Employee.

14. Governing
  Law

This
  Agreement shall be governed by and interpreted in accordance with the laws in
  effect in the Province of Manitoba.

15. No
  Assignment

Neither
  this Agreement, nor any rights or obligations hereunder, shall be assignable
  by the Employee.

16. Waivers

No
  waiver by the Employer of any breach of any of the covenants, provisoes, conditions
  or stipulations herein contained, whether express or implied or negative or
  positive in form, by the Employee, shall have any effect or be binding upon
  the Employer unless the same shall be in writing under the authority of the
  Employer, and any waiver shall extend only to the particular breach so waived
  and shall not limit or affect the rights of the Employer with respect to any
  other or further breach by the Employee.

Each
  and every term and provision in this Agreement shall be severable, one from
  the other, and should any court of competent jurisdiction interpreting this
  Agreement determine any provision or term hereof to be void or unenforceable,
  then the same shall be struck from this

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Agreement without in any way affecting the validity of any
  other term or provision of this Agreement.

18. Time
  of the Essence

Time
  shall in all respects be of the essence of this Agreement.

19. Successors
  and Assigns

This
  Agreement shall enure to the benefit of and be binding upon the Employer and
  the Employee, and their respective heirs, executors, administrators, successors,
  and other legal representatives and their respective successors.

20.Gender
  and Number

In
  this Agreement, words importing the singular include the plural and vice versa,
  and words importing gender include all genders.

THE EMPLOYEE HEREBY ACKNOWLEDGES THAT HE HAS READ THIS AGREEMENT,
  UNDERSTANDS IT, HAS HAD THE OPPORTUNITY TO OBTAIN INDEPENDENT LEGAL ADVICE IN
  RESPECT OF IT, AND AGREES TO ITS TERMS. The Employee acknowledges having received
  a fully executed copy of this Agreement.

IN
  WITNESS WHEREOF the parties hereto have duly executed this Agreement on the
  day and year first written above.

|                       |  | MEDICURE INC.
|---------------------- |  | -------------
|                       |  |              
|                       |  | Per:         
|                       |  |              
|                       |  |              
|                       |  |              
|"Ryan Wilkes"          |  | Per:         
|(Signature of witness) |  |              

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8

SCHEDULE A

TO

MEDICURE INC.

EMPLOYMENT AGREEMENT

DEFINITIONS

For
  purposes of the Employment Agreement utilized by Medicure Inc. (the "Employer"),
  together with any Schedule thereto, the following capitalized terms shall have
  the following meanings:

|1. | "Affiliate" means the Employer,
        together with any other corporation, regardless of its jurisdiction of
        incorporation, that:                                                                                      
|-- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|  
|   | (a)                                                                                                                                                                                                                              
|  
|   | (b)                                                                                                                                                                                                                              
|  
|   | (c)                                                                                                                                                                                                                              
|  
|   | For greater certainty, if pursuant to
        the foregoing definition two corporations are each affiliated with a third
        corporation at the same time they are deemed to be affiliated with each
        other.          
|  
|2. | "Agreement" means, collectively,
        the Employment Agreement executed by an Employee together with all Schedules
        then or thereafter attached thereto including, without limitation, the
        following Schedules:
|  

| |  | Schedule A | - | Definitions          
| |  | ---------- | - | ---------------------
| |  | Schedule B | - | Purpose of Employment
| |  | Schedule C | - | Developments Policy  

|3. | "Business"means the business of planning,
        supporting, financing, conducting, negotiating, contracting, sub-contracting
        or otherwise conducting or planning to conduct the activities associated
        with research, development, clinical trials, regulatory testing, compliance,
        manufacturing, distribution, marketing, sales, licensing, sub-licensing
        or other exploitation of cardiovascular products, and in particular such
        business in Canada and in the United States associated with the development
        of compounds which are currently or are planned for research and development
        by the Employer or any Affiliate and associated with target markets as
        selected by the Employer or any Affiliate.
|-- | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

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|4. | "Confidential Information" includes
        all of the following:
|-- | -----------------------------------------------------------------
|  
|   | (a)                                                              
|  
|   | (b)                                                              
|  
|   | (c)                                                              
|  
|   | (d)                                                              
|  
|   | (e)                                                              
|  
|   | (f)                                                              
|  
|   | (g)                                                              
|  
|   | (h)                                                              
|  
|   | (i)                                                              
|  
|   | (j)                                                              
|  
|   | (k)                                                              

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|   | (l)                                                                                                                                                                                                                                                                      | such information as a director, officer or senior
        employee of the Employer or any Affiliate may from time to time designate
        to the Employee as being included in the expression "Confidential Information";                                                                                                                                                                                                                
|-- | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|  
|   |                                                                                                                                                                                                                                                                          | whether the same may be contained in papers, microfilm,
        recordings, computer disks, magnetic storage or, without limitation, any
        other medium of storage of information; provided that Confidential Information
        does not include information which is or becomes generally available to
        the public without the fault of the Employee.                                                                      
|  
|5. | "Developments" means:                                                                                                                                                                                                                                                   
|  
|   | (a)                                                                                                                                                                                                                                                                      | all reports, products, scientific, and technical
        information or material;                                                                                                                                                                                                                                                                                                                                                          
|  
|   | (b)                                                                                                                                                                                                                                                                      | all inventions, devices, discoveries, concepts,
        ideas, algorithms, formulae, specifications, proposals, models, designs,
        processes, techniques, systems and improvements, test results and reports,
        analyses, simulation results, tables of operating conditions, materials,
        components, industrial skills, operating and testing procedures, know-how
        and show-how, whether patentable or not; and
|  
|   | (c)                                                                                                                                                                                                                                                                      | all software, documentation, data, designs, reports,
        flowcharts, trademarks, specifications and source code listings, and any
        related works, including any enhancements, modifications or additions
        to the products owned, marketed, licensed or used by the Employer or any
        Affiliate;                                                                                                                    
|  
|   | conceived, developed, created, generated,
        produced or reduced to practice by the Employee, alone or jointly with
        others, during the Employee's employment with the Employer and which:                                                                  
|  
|   | (d)                                                                                                                                                                                                                                                                      | are complimentary to or could reasonably be viewed
        as being competitive with any of the products owned or marketed by the
        Employer or any Affiliate; or                                                                                                                                                                                                                                                                    
|  
|   | (e)                                                                                                                                                                                                                                                                      | result from tasks assigned to the Employee by the
        Employer or any Affiliate; or                                                                                                                                                                                                                                                                                                                                                    
|  
|   | (f)                                                                                                                                                                                                                                                                      | result from the use of the premises or property
        (including equipment, supplies, materials or Confidential Information)
        owned, leased or licensed by the Employer or any Affiliate.                                                                                                                                                                                                                                         
|  
|   | Any Development so conceived, developed,
        created, generated, produced or reduced to practice shall constitute Confidential
        Information immediately upon such conception, development, creation, generation,
        production or reduction to practice.
|  
|6. | "Trade Secrets" means all information
        concerning or with respect to the Employer or any Affiliate and its respective
        business and affairs that:                                                                                                         
|  
|   | (a)                                                                                                                                                                                                                                                                      | derives economic value, actual or potential, from
        not being generally known to, and not being readily ascertainable by proper
        means by, other persons who can obtain economic value from the disclosure
        or use thereof; and                                                                                                                                                                                        

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| | (b)                                                                                                                                                                                                                                                                  | is the subject of efforts that are reasonable under the circumstances
      to maintain the secrecy thereof.
| | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- | ------------------------------------------------------------------------------------------------------------
| |                                                                                                                                                                                                                                                                      |                                                                                                             
| | In essence, Trade Secrets are the distinctive
        features of the operations of the Employer or any Affiliate that make
        the products or services of that corporation, and the way that that corporation
        conducts business, special, even unique.

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12

SCHEDULE B

TO

MEDICURE INC.

EMPLOYMENT AGREEMENT

|PURPOSE OF EMPLOYMENT                    |                                                                                                            
|---------------------------------------- | -----------------------------------------------------------------------------------------------------------
|                                         |                                                                                                            
|Purpose of Employment:                   | Directing the business development function of the Employer,
      including overseeing investor relations,
|                                         |                                                                                                            
|                                         |                                                                                                            
|Commencement Date:                       | October 1, 2001                                                                                            
|                                         |                                                                                                            
|Hours:                                   | Minimum 40 hours per week                                                                                  
|                                         |                                                                                                            
|Compensation:                            |                                                                                                            
|                                         |                                                                                                            
|                                         | Amount per hour or                                                                                         
|                                         | per annum, as applicable:                                                                                  
|                                         |                                                                                                            
|                                         | Payment:                                                                                                   
|                                         |                                                                                                            
|Benefits:                                |                                                                                                            
|                                         |                                                                                                            
|                                         | Vacation:                                                                                                  
|                                         |                                                                                                            
|                                         |                                                                                                            
|                                         | Bonuses:                                                                                                   
|                                         |                                                                                                            
|Contract (for purposes of  section 3(f): | None.                                                                                                      

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SCHEDULE C

TO

MEDICURE INC.

EMPLOYMENT AGREEMENT

DEVELOPMENTS POLICY

Violation of this Policy is grounds for discipline up to and including
  immediate dismissal for cause.

All Employees of Medicure Inc. (the "Employer") MUST comply with this
  Policy. By signing the Employer's Employment Agreement, each Employee agrees
  as follows:

|1. | To make full disclosure to the Employer of each
        Development promptly after its conception, development, creation, generation,
        production or reduction to practise.                                                                                                                                                                                                                                                                                                                                                                                                                             
|-- | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|  
|2. | To be deemed to have assigned and transferred to
        the Employer, automatically upon the conception, development, creation,
        generation, production or reduction to practise of any Development, and
        without further consideration, all of the Employee's right, title, and
        interest in and to each Development throughout the world, including all
        trade secrets, patent rights, copyrights, and all other intellectual property
        rights therein, with such deemed assignment and transfer to be treated
        in all respects as a formal assignment in writing.
|  
|3. | To recognize the Employer as the exclusive owner
        of all of the Employee's right, title, and interest in and to each Development
        throughout the world, including all trade secrets, patent rights, copyrights
        and all other intellectual property rights therein.                                                                                                                                                                                                                                                                                                                       
|  
|4. | To cooperate fully at all times during and subsequent
        to the Employee's employment with the Employer with respect to signing
        further documents and doing such acts and other things reasonably requested
        by the Employer to confirm such assignment and transfer of ownership of
        rights, including any and all intellectual property rights, effective
        at or after the time any Development is conceived, developed, created,
        generated, produced or reduced to practise and to obtain patents or copyrights
        or the like covering any Development.     
|  
|5. | To not require the Employer, its successors, assignees,
        and licensees to designate the Employee as the author of any Development.                                                                                                                                                                                                                                                                                                                                                                                                                                                                      
|  
|6. | To be deemed to have waived in whole all moral rights
        which the Employee may have in any Development, including the right to
        the integrity of the Development, the right to be associated with the
        Development, the right to restrain or claim damages for any distortion,
        mutilation or other modification of the Development, and the right to
        restrain use or reproduction of any Development in any context and in
        connection with any product, service, cause or institution, with such
        deemed waiver to be treated as a formal waiver in writing.
|  
|7. | To not knowingly infringe the intellectual property
        rights, including copyright, of any third party in the Employee's work
        creating any Development.                                                                                                                                                                                                                                                                                                                                                                                                                                           

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