|EXHIBIT 4.1



RESTATED CERTIFICATE OF
INCORPORATION OFIMPATH INC.


The
Restated Certificate of Incorporation of IMPATH Inc. (which was originally
incorporated in Delaware on March 1, 1988 under the name Biopath Inc.), is
hereby duly adopted in accordance with Section 245 of the General Corporation
Law of the State of Delaware. This Restated Certificate of Incorporation only
restates and integrates and does not further amend the provisions of the
Restated Certificate of Incorporation of the Corporation as heretofore amended
or supplemented and there is no discrepancy between those provisions and the
provisions of this Restated Certificate of Incorporation. The text of the
Restated Certificate of Incorporation as amended or supplemented heretofore is
hereby restated without further amendments or changes to read as herein set
forth in full:


ARTICLE I


NAME


The
name of the corporation is: IMPATH Inc.


ARTICLE II


PURPOSES


The
purpose of the corporation is to engage in any lawful act or activity for which
a corporation may be organized under the General Corporation Law of the State of
Delaware other than the banking business, the trust company business or the
practice of a profession not permitted to be incorporated by the General
Corporation Law of the State of Delaware.


ARTICLE III


AGENT FOR SERVICE


The
name and address in the State of Delaware of the corporations agent for
service of process is:
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| | The
Corporation Trust Company 1209 Orange Street, Corporate Trust Center Wilmington, Delaware
19801 County of New Castle, Delaware
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|ARTICLE IV


CAPITAL STOCK


The
total number of shares of capital stock which the corporation shall have
authority to issue is One Million (1,000,000) shares of preferred stock, $.01
par value per share (the Preferred Stock), and Seventy Million
(70,000,000) shares of common stock, $.005 par value per share (the Common
Stock).


(a)
Common Stock


Section
1. Voting Rights. The holders of shares of Common Stock shall be entitled to one vote for
each share so held with respect to all matters voted on by the shareholders of the
corporation.


Section 2. Liquidation
Rights. Subject to the liquidation rights of holders of Preferred Stock,
upon any voluntary or involuntary liquidation, dissolution or winding up of the
corporation, the holders of Common Stock shall be entitled to receive all assets
of the corporation available for distribution to its stockholders.


Section
3. Dividends. Dividends may be paid on the Common Stock as and when declared by the Board
of Directors, out of funds legally available therefor, subject to the rights of holders
of Preferred Stock.


Section
4. Rights of First Refusal. A holder of shares of Common Stock shall have the
rights of first refusal, if any, to subscribe to an additional issue of capital stock of
the corporation or of any security convertible into capital stock of the corporation as
are set forth in a StockholdersAgreement dated on or about February 9, 1995, if
such holder is a party thereto, subject to the terms and conditions off such agreement,
as such agreement may be amended from time to time.


(b)
Preferred Stock. The powers, designations, preferences and relative, participating,
optional or other special rights, qualifications, limitations or restrictions of the Preferred Stock shall be as follows:


Section
1. (A) The Preferred Stock may be issued from time to time as shares of one or more
series of Preferred Stock, and in the resolution or resolutions providing for the issue
of shares of each particular series, before issuance, the Board of Directors of the
corporation is expressly authorized to fix:
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| | (i)
the distinctive designation of such series and the number of shares which shall
constitute such series, which number may be increased (except where otherwise provided by
the Board of Directors in creating such series) or decreased (but not below the number of
shares thereof then outstanding) from time to time by like action of the Board of
Directors;
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| | (ii)
the rate of dividends payable on such series, whether or not such dividends shall be
cumulative, the date or dates from which dividends shall accrue and, if cumulative, the
relationship with which such dividends shall bear to dividends payable on any other
series;
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| | (iii)
whether or not the shares of such series shall be subject to redemption by the
corporation and, if so, the times, prices and other terms and conditions of such
redemption;
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| | (iv)
whether or not the shares of such series shall be subject to the operation of a sinking
fund or a fund or a similar nature and, if so, the terms thereof;
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| | (v)
the rights of the shares of each series in case of liquidation, dissolution or winding up
of the corporation, whether voluntary or involuntary, or upon distribution of its assets;
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| | (vi)
whether or not the shares of such series shall be convertible into or exchangeable for
shares of any other series or class of stock of the corporation and, if so, the terms of
conversion or exchange;
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| | (vii)
whether or not the shares of such series shall have voting rights in addition to the
voting rights provided by law and in Section 5 below and, if so, the nature and extent
thereof; and
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| | (viii)
the consideration to be received by the corporation for the shares of such series.
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| | (B) The
shares of the Preferred Stock of any one series shall be identical with each other in all
respects except as to the dates from which dividends thereon shall accrue or be
cumulative.
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| | (C) In
case the stated dividends and the amounts, if any, payable on liquidation, dissolution or
winding up of the corporation are not paid in full, the shares of each series of the
Preferred Stock, after the payment in full of such dividends and amounts to all series of
the Preferred Stock ranking senior to such series and before any payment to any series
ranking junior thereto, shall share ratably in the payment of dividends, including
accumulations, if any, in accordance with the sums which would be payable on said shares
if all dividends were declared and paid in full, and in any distribution of assets other
than by way of dividends, in accordance with the sums which would be payable on such
distribution if all sums payable were discharged in full.
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| | (D) Upon
the issuance of any series of Preferred Stock, a certificate setting forth the resolution
or resolutions (including the designation, description ad terms of such series) adopted
by the Board of Directors with respect to such series shall be made and filled in
accordance with the then applicable requirements, if any, of the laws of the State of
Delaware, or, if no certificate is then so required, such certificate shall be signed and
acknowledged on behalf of the corporation by its President or a Vice President, and its
corporate seal shall be affixed thereto and attested by its Secretary or an Assistant
Secretary, and such certificate shall be filed and kept on file at the principal office
of the corporation in the State of Delaware or at such other place or places as the Board
of Directors shall designate.
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|Section
2. The holders of each series of the Preferred Stock shall be entitled to receive, when
and as declared by the Board of Directors, but only out of funds of the corporation
legally available for the payment of dividends, dividends in cash at the annual rate for
such series provided by the Board of Directors in the certificate made pursuant to
paragraph (D) of Section 1 with respect to such series, before any dividends shall be
declared and paid upon or set apart for the holders of any series of he Preferred Stock
ranking junior to such series as to dividends or of any Junior Stock (as hereinafter
defined), payable in respect of each calendar quarter on a date, which shall be provided
by the Board of Directors in such certificate with respect to such series, within fifty
(50) days following the end of such quarter. Such dividends on the Preferred Stock shall
be payable to the holders of such series of record on the date, not exceeding fifty (50)
days preceding the dividend payment date, fixed for such purpose by the Board of
Directors with respect to such series in advance of the payment of each particular
dividend.


Section
3. If so provided by the Board of Directors in the certificate made pursuant to paragraph
(D) of Section 1 with respect to any series of the Preferred Stock, the corporation may
redeem the whole or any part of such series, at such time or times and from time to time
and at such redemption price or prices as may be provided by the Board of Directors in
such certificate and otherwise upon the terms and conditions fixed by the Board of
Directors for any such redemptions.


Section
4. In the event of any liquidation, dissolution or winding up of the corporation, whether
voluntary or involuntary, the holders of each series of the Preferred Stock then
outstanding shall be entitled to receive, after the payment in full of all amounts to
which to which the holders of all series of the Preferred Stock ranking senior thereto
are entitled, out of the assets of the corporation, before any distribution or payment
shall be made to the holders of any series of the Preferred Stock ranking junior to such
series upon liquidation, dissolution or winding up of the corporation or of any Junior
Stock, the amount, if any, for each share provided by the Board of Directors in the
certificate made pursuant to paragraph (D) of Section 1. If payment shall have been made
in full to the holders of each series of the Preferred Stock, the remaining assets of the
corporation shall be distributed among the holders of the Junior Stock, according to
their respective rights and preferences and pro rata in accordance with their respective
holdings.
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|Section
5. On all matters with respect to which holders of the Preferred Stock or of certain
series thereof are entitled to vote as a single class, each holder of Preferred Stock
afforded such class voting right shall be entitled to one vote for each share held.


Section
6. For purposes of this Article IV, the term Junior Stockshall mean the
Common Stock and any other class of stock of the corporation hereafter authorized which
shall rank junior to all series of the Preferred Stock as to all dividends or preference
on dissolution, liquidation or winding up of the corporation.


ARTICLE V


ADDITIONAL PROVISIONS


Section
1. Existence. The corporation is to have perpetua1 existence.


Section
2. Amendments to By-laws. In furtherance and not in limitation of the powers conferred by
statute, the Board of Directors is authorized to adopt, amend and repeal the by-laws of
the corporation.


Section
3. Meetings of Stockholders. Meetings of stockholders may be held within or
without the State of Delaware, as the by-laws may provide. The books of the corporation
may be kept (subject to any provisions contained in the statutes) outside the State of
Delaware at such place or places as may be designated from time to time by the Board of
Directors or in the by-laws of the corporation. Elections of directors need not be by
written ballot unless the by-laws of the corporation shall so provide.


Section
4. Number of Directors. The number of directors of the corporation shall be fixed from
time to time by a by-law or amendment thereof adopted by the Board of Directors.


Section
5. Amendments to Certificate of Incorporation. The corporation reserves the right
to amend, alter, change or repeal any provision contained in this certificate of
incorporation, in the manner now or hereafter prescribed by statute, and all rights
conferred on stockholders herein are granted subject to this reservation.


Section
6. Liability of Directors. No director of the corporation shall be personally
liable to the corporation or any of its stockholders for monetary damages for breach of
fiduciary duty as a director, except for liability, to the extent that such liability is
imposed by applicable law, (i) for any breach of the directors duty of loyalty to
the corporation or its stockholders, (ii) for acts or omissions not in good faith or
which involve intentional misconduct or a knowing violation of law, (iii) under Section
174 of the Delaware General Corporation Law, as the same exists or hereafter may be
amended, or any successor provisions or (iv) for any transaction from which the director
derived an improper personal benefit. If the Delaware General Corporation Law is amended
hereafter to authorize the further elimination or limitation of the liability of
directors, then the liability of a director of the corporation, in addition to the
limitation on personal liability provided herein, shall be limited to the fullest extent
permitted by the amended Delaware General Corporation Law. Any repeal or modification of
this Article by the stockholders of the corporation shall be prospective only, and shall
not adversely affect any limitation on the personal liability of a director of the
corporation existing at the time of such repeal or modification.
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|Section
7. Right to Indemnification.
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| | (A) Each
person who was or is made a party or is threatened to be made a party to or is involved
in any action, suit or proceeding, whether civil, criminal, administrative or
investigative (hereinafter, a proceeding), by reason of the fact that he or
she, or a person of whom she is the legal representative, is or was a director or
officer, of the corporation or, at the request of the corporation, of a partnership,
joint venture, trust or other enterprise, including service with respect to employee
benefit plans, whether the basis of such proceeding is alleged action in any official
capacity as a director, officer, employee or agent or in any other capacity while serving
as a director, officer, employee or agent, shall be indemnified and held harmless by the
corporation to the fullest extent authorized by the Delaware General Corporation Law, as
the same exists or may hereafter be amended (but, in the case of any such amendment, only
to the extent that such amendment permits the corporation to provide broader
indemnification rights than said law permitted the corporation to provide prior to such
amendment), against all expense, liability and loss (including attorneys fees,
judgments, fines, excise taxes or penalties under the Employee Retirement Income Security
Act of 1974, as amended, and amounts paid or to be paid in settlement) reasonably
incurred or suffered by such person in connection therewith and such indemnification
shall continue as to a person who has ceased to be a director, officer, employee or agent
and shall inure to the benefit of his or her heirs, executors and administrators; provided,
however, that, except as provided in paragraph (B) of this Article V, Section 7,
the corporation shall indemnify any such person seeking indemnification in connection
with a proceeding (or part thereof) initiated by such person only if such proceeding (or
part thereof) was authorized by the Board of Directors of the corporation. The right to
indemnification conferred in this Article V, Section 7 shall be a contract right and
shall include the right to be paid by the corporation the expenses incurred in defending
any such proceeding in advance of its final disposition; provided, however, that,
if the Delaware General Corporation Law requires, the payment of such expenses incurred
by a director or officer in his or her capacity as a director or officer (and not in any
other capacity in which service was or is rendered by such person while a director or
officer, including, without limitation, service to an employee benefit plan) in advance
of the final disposition of a proceeding, shall be made only upon delivery to the
corporation of an undertaking, by or on behalf of such director or officer, to repay all
amounts so advanced if it shall ultimately be determined that such director or officer is
not entitled to be indemnified under this Article V, Section 7 or otherwise. The
corporation may, by action of its Board of Directors, provide indemnification to
employees and agents of the corporation with the same scope and effect as the foregoing
indemnification of directors and officers.
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| | (B) If
a claim under paragraph (A) of this Article V, Section 7 is not paid in full by the
corporation within thirty days after a written claim has been received by the
corporation, the claimant may at any time thereafter bring suit against the corporation
to recover the unpaid amount of the claim and, if successful in whole or in part, the
claimant shall be entitled to be paid also the expense of prosecuting such claim. It
shall be a defense to any such action (other than an action brought to enforce a claim
for expenses incurred in defending any proceeding in advance of its final disposition
where the required undertaking, if any is required, has been tendered to the corporation)
that the claimant has not met the standards of conduct which make it permissible under
the Delaware General Corporation law for the corporation to indemnify the claimant for
the amount claimed, but the burden of proving such defense shall be on the corporation.
Neither the failure of the corporation (including its Board of Directors, independent
counsel, or its stockholders) to have made a determination prior to the commencement of
such action that indemnification of the claimant is proper in the circumstances because
he or she has met the applicable standard of conduct set forth in the Delaware General
Corporation Law, nor an actual determination by the corporation (including its Board of
Directors, independent legal counsel, or its stockholders) that the claimant has not met
such applicable standard or conduct, shall be a defense to the action or create a
presumption that the claimant has not met the applicable standard of conduct.
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| | (C) Non-Exclusivity
of Rights. The right to indemnification and the payment of expenses incurred in
defending a proceeding in advance of its final disposition conferred in this Article V,
Section 7 shall not be exclusive of any other right which any person my have or hereafter
acquire under any statute, provision of the certificate of incorporation, by-law,
agreement, vote of stockholders or disinterested directors or otherwise.
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| | (D) Insurance.
The corporation may maintain insurance, at its expense, to protect itself and any
director, officer, employee or agent of the corporation or another corporation,
partnership, joint venture, trust or other enterprise against such expense, liability or
loss, whether or not the corporation would have the power to indemnify such person
against such expense, liability or loss under the Delaware General Corporation Law.
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|Section
8. Arrangements with Creditors or Stockholders. Whenever a compromise or
arrangement is proposed between this corporation and its creditors or any class of them
and/or between this corporation and its stockholders or any class of them, any court of
equitable jurisdiction within the State of Delaware may, on the application in a summary
way of this corporation or of any creditor or stockholder thereof or on the application
of any receiver or receivers appointed for this corporation under the provisions of
Section 291 of Title 8 of the Delaware Code or on the application of trustees in
dissolution or of any receiver or receivers appointed for this corporation under the
provisions of section 279 of Title 8 of the Delaware Code order a meeting of the
creditors or class of creditors, and/or of the stockholders or class of stockholders of
this corporation, as the case may be, to be summoned in such manner as the said court
directs. If a majority in number representing three-fourths in value of the creditors or
class of creditors, and/or of the stockholders or class of stockholders of this
corporation, as the case may be, agree to any compromise or arrangement and to any
reorganization of this corporation as a consequence of such compromise or arrangement,
the said compromise or arrangement and the said reorganization shall, if sanctioned by
the court to which the said application has been made, be binding on all the creditors or
class of creditors, and/or on all the stockholders or class of stockholders, of this
corporation, as the case may be, and also on this corporation.
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|IN
WITNESS WHEREOF, IMPATH Inc. has caused this Restated Certificate of
Incorporation to be signed this 16th day of July 2002 in its name and on its
behalf by its Secretary, pursuant to Section 103(a) of the General Corporation
Law of the State of Delaware.
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| |  | IMPATH INC.By: /s/ Richard C. Rosenzweig
Name: Richard C. RosenzweigTitle: Secretary
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