Exhibit 10.25  


[Epocrates,
Inc. Letterhead] 


January 28,
2011 


Patrick
D. Spangler



Re:        Employment
Terms 


Dear
Pat, 


        As
we have discussed, this letter confirms an amendment and restatement (the "Amendment") to the terms of your employment offer letter
with Epocrates, Inc. (the "Company") dated September 29, 2010 (the "Offer Letter"). This
Amendment supersedes and replaces in full the Offer Letter and is effective as of January 28, 2011. You hereby agree that your option grant documentation with respect to the Milestone-Based
Vesting Option (as defined below) is hereby amended to reflect the terms set forth herein. On behalf of Epocrates, Inc. ("Epocrates" or the
"Company"), the amended and restated terms and conditions of your position and employment relationship with the Company are as set forth below: 


1.    Position and Work Schedule.    



        a.     You
will become the Chief Financial Officer for the Company. You will report directly to the Chief Executive Officer and will initially split your time working between
the Company's offices in East Windsor, New Jersey and San Mateo, California. As discussed, we will allow you to determine which of these office locations will be your primary office location, and you
are expected to relocate to that particular geographic area by the end of July, 2011. This is a full-time position. 


        b.     You
agree to the best of your ability and experience that you will at all times conscientiously perform all of the duties and obligations required of you to the
satisfaction of the Company. During the term of your employment, you further agree that you will devote your full business time and attention to the business of the Company, the Company will be
entitled to all of the benefits and profits arising from or incident to all such work services and advice, you will not render commercial or professional services of any nature to any person or
organization, or engage in self-employment, whether or not for compensation, without the prior written consent of the Company, and you will not directly or indirectly engage or participate
in any business that is competitive in any manner with the business of the Company. Nothing in this letter agreement will prevent you from accepting speaking or presentation engagements in exchange
for honoraria or from serving on boards of charitable organizations, or from owning no more than one percent (1%) of the outstanding equity securities of a corporation whose stock is listed on a
national stock exchange. 


        c.     Of
course, the Company may change your position, duties, reporting relationship and office location from time to time in its discretion (provided
however, that as provided under Section 12 of this letter agreement, certain actions by the Company could constitute "Good Reason" for your resignation of employment and
eligibility for Change of Control Severance Benefits). 


2.    Start Date.    Subject to fulfillment of any conditions imposed by this letter agreement, you will
commence this new position with the Company on October 4, 2010 or any other mutually agreeable date (the "Start Date"). 


3.    Proof of Right to Work.    For purposes of federal immigration law, you will be required to provide to
the Company documentary proof of your identity and eligibility for employment in the United States. This offer of employment is contingent upon such satisfactory proof. 


4.    Compensation.    


        a.    Base Salary.    Your initial base salary will be payable in semi monthly installments of
$12,500 pursuant to the Company's regular payroll policy, which equates to an annual base salary of $300,000. Because your position is classified as exempt, you will not be eligible for overtime
premiums or 











additional
compensation. Your base salary may be reviewed annually as part of the Company's normal salary review process. Any changes to your base salary are at the Company's sole discretion
(provided however, that as provided under Section 12 of this letter agreement, a material decrease in your base salary could constitute "Good
Reason" for your resignation of employment and eligibility for Change of Control Severance Benefits). 


        b.    Bonus Compensation.    You will be eligible to participate in the 2010 Executive Bonus
Plan (the "Bonus Plan"), pursuant to the terms and conditions of the Bonus Plan. Your target bonus under the Bonus Plan will be 60% of your 2010 base
salary paid by the Company, and the actual bonus paid will be based upon the Company's performance (as determined by the Company) against the Bonus Plan. No bonus is considered earned under the Bonus
Plan until the time that such bonus is scheduled to be paid as provided under the Bonus Plan. Thus, in the event that your employment has been terminated (either by the Company or by you), you will
not be entitled to any bonus which has not been scheduled to be paid prior to the termination date. Any bonus for 2010 will be prorated based on your Start Date. Whether a bonus has been earned under
the Bonus Plan, and the amount of any bonus earned, will be determined by the Company and approved by the Company's Board of Directors (the "Board")
within its sole discretion. Any bonus earned will be paid as soon as practicable following the approval of the Bonus Plan payouts by the Board, as provided under the Bonus Plan. 


        c.    Relocation Benefits.    To assist with your relocation to the San Francisco Bay Area or
New Jersey (as discussed further above), the Company will provide you with the relocation assistance and benefits in the form of reimbursement (or direct payment to vendors or other service providers)
of your reasonable direct out-of-pocket costs for your temporary lodging and transportation costs incurred by you prior to your relocation (collectively, the
"Relocation Benefits"). The Relocation Benefits that you will be eligible to receive include, but are not limited to the following: (i) within
each calendar quarter prior to your relocation (beginning with the fourth calendar quarter of 2010), the Company will reimburse your direct out-of pocket costs for up to six
(6) round trip coach class airfare tickets to/from your current primary residence and the Bay Area or New Jersey, such tickets to be used by either you or your spouse and child(ren);
(ii) the Company will reimburse the management fees that you will be required to pay during the time period through September 30, 2011 to the property management company which assists
with the renting or leasing of your primary residence in Minnesota, up to a maximum of one thousand dollars ($1,000.00) per month; and (iii) the Company will reimburse your direct
out-of-pocket costs to move your household goods and other personal property to the Bay Area or New Jersey, up to a maximum of thirty thousand dollars ($30,000) in the
aggregate, provided that, such goods and personal property must be moved no later than July 31, 2011. The Relocation Benefits (or portions
thereof) may be subject to deductions and withholdings, as provided by applicable law. 


        Any
reimbursement-based Relocation Benefits will be paid to you within thirty (30) days after the date you submit receipts for the expenses, provided you submit those receipts and
a properly completed
expense reimbursement report within forty-five (45) days after you incur the expense. For the avoidance of doubt, to the extent that any such reimbursements are subject to the
provisions of Section 409A of the Internal Revenue Code of 1986, as amended, any such reimbursements payable pursuant to this Section 4(c) shall be paid no later than December 31
of the year following the year in which the expense was incurred, the amount of expenses reimbursed in one year shall not affect the amount eligible for reimbursement in any subsequent year, and the
right to reimbursement under this letter agreement will not be subject to liquidation or exchange for another benefit. To be eligible for reimbursement or payment by the Company, you must remain an
employee of the Company in good standing as of the date that the expense or cost is incurred. 


        In
addition, if any of the Relocation Benefits constitute taxable income to you, then after the amount of income tax and employment tax imposed on the Relocation Benefits can be
determined and substantiated to the Company's satisfaction (in accordance with the procedures set forth in this paragraph), the Company shall pay either to you or to the applicable taxing authorities
on your behalf (as required by applicable tax withholding rules determined and applied in the Company's good faith discretion), such additional amount (the
"Gross-Up") as is necessary to ensure that you do not bear any income or employment taxes attributable to the Relocation Benefits. For the
avoidance of doubt, 










the
Gross-Up shall be calculated iteratively so that you do not bear income or employment taxes on the Gross-Up. The Gross-Up shall be calculated using your actual
effective marginal federal and state income tax rates based on your federal and state income tax returns as actually filed for the taxable years in which the Relocation Benefits are paid. You will
provide such tax returns to the Company for purposes of the Company's calculation of the Gross-Up no later than September 30 of the year in which such income tax returns are filed
and the Gross-Up will be paid by the Company no later than December 31 of such year. 


5.    Stock Options.    


        a.    Stock Option Grant With Time-Based Vesting.    In connection with the
commencement of your employment, the Company will recommend that the Board grant you an option to purchase one hundred ninety-one thousand, nine hundred forty-seven (191,947) shares of the
Company's Common Stock under the Company's equity incentive plan (the "Plan") with an exercise price equal to the fair market value on the date of the
grant as determined by the Board (the "Time-Based Vesting Option"). The Time-Based Vesting Option will be subject to approval of
the Board and the terms of the Plan and your individual Stock Option Agreement with the Company, which shall include the following five-year vesting schedule applicable to the shares
subject to the Time-Based Vesting Option: twenty percent (one-fifth) of such shares shall vest on the first annual anniversary of the Start Date, and
1/60th of such shares shall vest monthly thereafter over the next four years. Vesting will, of course, depend on your continued service with the Company, as defined by the Plan.
The Time-Based Vesting Option will be an incentive stock option to the maximum extent allowed by the tax code. 


        b.    Stock Option Grant With Milestone-Based Vesting.    In addition, the Company will
recommend that the Board grant you an additional option (separate from the Time-Based Vesting Option) to purchase one hundred ninety-one thousand, nine hundred forty-seven
(191,947) shares of the Company's Common Stock under the Plan with an exercise price equal to the fair market value on the date of the grant as determined by the Board (the
"Milestone-Based Vesting Option"). The Milestone-Based Vesting Option will be subject to approval of the Board and the terms of the Plan and your
individual Stock Option Agreement with the Company, which shall include a vesting schedule pursuant to which the shares subject to the Milestone-Based Vesting Option will vest as provided below upon
an IPO (as hereinafter defined) in the event that such event occurs within one (1) year after the Start Date. The vesting schedule which will apply to the Milestone-Based Vesting Option, if an
IPO does not occur within one (1) year after the Start Date, also is provided below: 



        (i)    IPO Milestone.    In the event of the initial public offering of the Company's
securities on a national stock exchange within one (1) year after the Start Date (the "IPO") and you remain in continuous service (as defined in
the Plan) through and including the date of the IPO (the "IPO Date"), the shares subject to the Milestone-Based Vesting Option will vest in accordance
with the following schedule, subject to your continuous service (as defined in the Plan): twenty percent (one-fifth) of the shares subject to the Milestone-Based Vesting Schedule shall
vest on the first annual anniversary of the Start Date, and 1/60th of such shares shall vest monthly thereafter over the next four years. In the event of an IPO, the
Milestone-Based Vesting Option will be eligible for accelerated vesting under Section 12 of this offer letter agreement (Change of Control Severance Benefits). 



        (ii)    Traditional Vesting Schedule.    If an IPO does not occur as of the one
(1) year anniversary of the Start Date, then effective as of such one (1) year anniversary date, the shares subject to the Milestone-Based Vesting Option will vest in accordance with the
following schedule, subject to your continuous service (as defined in the Plan) (the "Traditional Vesting Schedule"): twenty percent
(one-fifth) of the shares subject to the Milestone-Based Vesting Schedule shall vest on the one (1) year anniversary of the Start Date, and 1/60th of such
shares shall vest monthly thereafter over the next four years. If the Traditional Vesting Schedule applies, the Milestone-Based Vesting Option will be eligible for accelerated vesting under
Section 12 of this offer letter agreement (Change of Control Severance Benefits). 









6.    Benefits.    Subject to the terms, conditions and limitations of the benefit plans, you will be
eligible to participate in the Company's standard employee benefits currently consisting of short/long term disability, medical, dental, and vision insurance benefits. Eligibility for participation in
these group benefits will become effective the first of the month following your Start Date. Regular full-time and part-time exempt employees do not accrue vacation, sick
leave, or other paid time off, and there is no set guideline on how much time off employees will be permitted to take. Under the terms of the Company's paid time off policy for exempt employees, you
will be permitted to take a reasonable amount of time off with pay, as permitted by your duties and responsibilities, and as approved in advance by your manager. Further details about benefits are
available for your review. Epocrates may modify benefit plans available to employees from time to time at its discretion, and you will remain eligible to participate in the Company's benefit plans
which apply to executive level employees of the Company. 


7.    Employee 401(k) Plan.    You will be eligible to participate in Epocrates' 401(K) plan beginning on
the first of the month following your Start Date. Employees who choose to participate will have pre-tax dollars deposited into their 401(K) account and the money will be directed to
specified investment options. Epocrates does not match funds or make contributions. 


8.    Confidential Information and Invention Assignment Agreement.    Your acceptance of this offer and
commencement of employment with the Company is contingent upon the execution, and delivery to an officer of the Company, of the Company's Confidential Information and Invention Assignment Agreement
(the "Confidentiality Agreement"), a copy of which is enclosed for your review and execution, prior to or on your Start Date. You are also required to
abide by the Confidentiality Agreement as a condition of your employment. In your work for the Company, you will be expected not to use or disclose any confidential information, including trade
secrets, of any former employer or other person to whom you have an obligation of confidentiality. Rather, you may use only that information generally known and used by persons with training and
experience comparable to your own, which is common knowledge in the industry or otherwise legally in the public domain, or which is otherwise provided or developed by the Company, or developed by you
on behalf of the Company. You agree that you will not bring onto Company premises any unpublished documents or property belonging to any former employer or other person to whom you have an obligation
of confidentiality. You represent further that you have disclosed to the Company any contract you have signed that may restrict your activities on behalf of the Company. 


9.    Company Policies.    As a condition of your employment, you will be expected to abide by the Company
policies and procedures, and acknowledge in writing that you have read and will comply with the Company's Employee Handbook. 


10.    At-Will Employment.    Your employment with the Company will be on an "at will" basis,
meaning that either you or the Company may terminate your employment at any time, with or without cause, and with or without advance notice. Your employment at-will status can only be
modified in a written agreement signed by you and by a duly authorized officer of the Company. 


11.    Severance Benefits Not In Connection With A Change of Control.    If, at any time other than during
the twelve (12) months following the consummation of a Change of Control (as defined herein), the Company or any successor entity terminates your employment without Cause (as defined herein),
and if, on or within thirty (30) days after the termination date, you sign, date, and deliver to the Company a separation agreement that includes a general release of all known and unknown
claims in the form provided to you by the Company (the "Release") and you do not subsequently revoke the Release, then you will receive the following as
your sole severance benefits (the "Severance Benefits"): (i) severance pay equal to nine (9) months of your base salary in effect as of
the termination date, less required deductions and withholdings, paid in the form of salary continuation on the Company's standard payroll dates beginning with the first payroll date following the
thirtieth day after the termination date (provided that the Release has become effective by such payroll date, and the initial severance payment will be a "catch-up" payment that provides
the full amount of severance pay that you would have received if the severance payments had begun as of the first payroll date following the termination 










date);
and (ii) provided that you timely elect continued group health insurance coverage through federal COBRA law or comparable state law (collectively,
"COBRA"), the Company will pay your COBRA premiums sufficient to continue your group health insurance coverage at the same level in effect as of your
termination date for nine (9) months after your termination or until you become eligible for group health insurance coverage through a new employer, whichever occurs first. For purposes of this
letter agreement, "Cause" means any of the following conduct by you: (i) embezzlement, misappropriation of corporate funds, or other material
acts of dishonesty; (ii) the conviction, plea of guilty, or nolo contendere to any felony (not involving the operation of a motor vehicle), or of any misdemeanor involving moral turpitude;
(iii) engagement in any activity that you know or should know could materially harm the business or reputation of the Company, provided that this subsection (iii) shall not apply to any
activity done in a good faith belief by you that the action taken or omission was in the best interest of the Company; (iv) material violation of any statutory, contractual, or common law duty
or obligation owed by you to the Company, including, without limitation, the duty of loyalty which causes demonstrable injury to the Company; (v) material breach of the Confidentiality
Agreement; or (vi) repeated failure, in the reasonable judgment of the Company, to substantially perform your assigned duties or responsibilities after written notice from the Company
describing the failure(s) in reasonable detail and your failure to cure such failure(s) within thirty (30) days of receiving such written notice, provided that written notice only must be
provided if the failure(s) are capable of cure. 


12.    Change of Control Severance Benefits.    In the event that: (i) the Company consummates a
change of control transaction, whereby fifty percent (50%) or more of the voting stock of the Company changes ownership pursuant to such transaction (a "Change of
Control"); and (ii) within twelve (12) months after the consummation of a Change of Control, your employment with the Company is either (a) terminated by
the Company or successor entity without Cause, or (b) terminated by you for Good Reason (as defined in and in accordance with the paragraph below); and (iii) if, on or within thirty
(30) days after the termination date, you sign, date, and deliver to the Company the Release and you do not subsequently revoke the Release; then you will receive the following as your sole
severance benefits (the "Change of Control Severance Benefits"): (a) severance pay equal to nine (9) months of your base salary in effect
as of the termination date, less required deductions and withholdings, paid in the form of salary continuation on the Company's standard payroll dates beginning with the first payroll date following
the thirtieth day after the termination date (provided that the Release has become effective by such payroll date, and the initial severance payment will be a "catch-up" payment that
provides the full amount of severance pay that you would have received if the severance payments had begun as of the first payroll date following the termination date); (b) provided that you
timely elect continued group health insurance coverage through COBRA, the Company will pay your COBRA premiums sufficient to continue your group health insurance coverage at the same level in effect
as of your termination date for nine (9) months after your termination or until you become eligible for group health insurance coverage through a new employer, whichever occurs first; and
(c) any unvested shares subject to any option grants held by you as of the employment termination date will become vested, effective as of the employment termination date (unless otherwise
provided under Section 5). 


        For
purposes of this Section 12, "Good Reason" shall mean one or more of the following conditions that arose upon or following the
consummation of the Change of Control without your written consent: (i) a relocation of your assigned office which results in an increase in your one-way commuting distance by more
than thirty-five (35) miles; (ii) a material decrease in your base salary (except for salary decreases generally applicable to the Company's other executive employees); or
(iii) a material reduction in the scope of your duties or responsibilities from your duties and responsibilities in effect immediately prior to the Change of Control. Notwithstanding the
foregoing, you shall not be deemed to have terminated your employment for "Good Reason" unless (i) such termination occurs within ninety (90) days following the initial existence of one
or more of the conditions that constitute Good Reason (as defined herein), (ii) you provide written notice to the Company (or any successor entity) of the existence of the Good Reason condition
within thirty (30) days following the initial existence of the condition, and (iii) the Company (or its successor entity) fails to cure such condition within a period of thirty
(30) days following such written notice. 








13.    Parachute Payments.    In the event that the benefits provided for in this letter agreement or
otherwise payable to you ("Payment") would constitute "parachute payments" within the meaning of Section 280G of the Internal Revenue Code of
1986, as amended (the "Code") and, but for this sentence, would be subject to the excise tax imposed by Section 4999 of the Code (the
"Excise Tax"), then such Payment shall be equal to the Reduced Amount. The "Reduced Amount" shall be
either (i) the largest portion of the Payment that would result in no portion of the Payment being subject to the Excise Tax, or (ii) the largest portion, up to and including the total,
of the Payment, whichever of the foregoing amounts, after taking into account all applicable federal, state and local employment taxes, income taxes and the Excise Tax (all computed at the highest
applicable marginal rate), results in the receipt by you, on an after-tax basis, of the greater amount of the Payment, notwithstanding that all or some portion of the Payment may be
subject to the Excise Tax. Unless the Company and you otherwise agree in writing, the determination of your Excise Tax liability shall be made in writing by the accounting firm engaged by the Company
for general audit purposes as of the day prior to the effective date of the Change of Control (the "Accountants"). If the accounting firm so engaged by
the Company is serving as accountant or auditor for the individual, entity or group effecting the Change of Control, the Company shall appoint a nationally recognized accounting firm to make the
determinations required hereunder. For purposes of making the calculations required by this Section 13, the Accountants may make reasonable assumptions and approximations concerning applicable
taxes and may rely on reasonable, good faith interpretations concerning the application of Sections 280G and 4999 of the Code. Any good faith determinations of the Accountants made hereunder
shall be final, binding, and conclusive upon the Company and you. The Company and you shall furnish to the Accountants such information and documents as the Accountants may reasonably request in order
to make a determination under this Section. The Company shall bear all costs the Accountants may reasonably incur in connection with any calculations contemplated by this Section 13. To the
extent that any elimination in or reduction of payments or benefits is made under this Section 13, the order in which payments and benefits shall be reduced shall be made by the Accountants in
a manner that shall provide you with the greatest economic benefit, but if more than one manner of reduction of payments and benefits necessary to arrive at the Reduced Amount yields the greatest
economic benefit to you, then the payments and benefits shall be reduced pro rata. 


14.    Deferred Compensation.    Severance payments made pursuant to Section 11 or Section 12,
to the extent of payments made from the date of your termination through March 15 of the calendar year following your termination, are intended to constitute separate payments for purposes of
Section 1.409A-2(b)(2) of the Treasury Regulations and thus payable pursuant to the "short-term deferral" rule set forth in Section 1.409A-1(b)(4) of
the Treasury Regulations. To the extent such payments are made following said March 15, they are intended to constitute separate payments for purposes of
Section 1.409A-2(b)(2) of the Treasury Regulations made upon an involuntary termination from service and payable pursuant to Section 1.409A-1(b)(9)(iii) of the
Treasury Regulations, to the maximum extent permitted by such provision, with any excess amount being regarded as subject to the distribution requirements of Section 409A(a)(2)(A) of the Code,
including, without limitation, the requirement of Section 409A(a)(2)(B)(i) of the Code that payment be delayed until six (6) months after separation from service if you are a "specified
employee" within the meaning of Section 409A(a)(2)(B)(i) of the Code at the time of such separation from service. Notwithstanding anything to the contrary set forth herein, if any payments and
benefits provided under this Agreement constitute "deferred compensation" within the meaning of Section 409A of the Code and the regulations and other guidance thereunder and any state law of
similar effect (collectively "Section 409A") (i) such payments and benefits shall not commence in connection with your termination of
employment unless and until you also have incurred a "separation from service" (as such term is defined in Treasury Regulations Section 1.409A-1(h)), unless the Company reasonably
determines that such amounts may be provided to you without causing you to incur the adverse personal tax consequences under Section 409A, and (ii) the Release required by
Sections 11 and 12 above shall be considered effective only as of the latest permitted effective date for such Release if such Release could become effective in the calendar year following the
calendar year in which your employment termination occurs. 


15.    Complete Agreement.    This letter, together with your Confidentiality Agreement, forms the complete
and exclusive statement of your employment agreement with the Company. The terms in this letter supersede any other agreements or promises made to you by anyone, whether oral or written. Other than
those changes expressly reserved to the Company's discretion in this letter, this letter agreement cannot be changed except in a written agreement signed by you and a duly authorized officer of the
Company. 








        Please
sign below if these terms are acceptable to you, and return the fully signed Amendment to me within five (5) business days. 



Very
truly yours,

Epocrates, Inc. 


/s/
John Owens 


John
Owens

Senior Vice President

Human Resources 

 






 



			
	
 UNDERSTOOD, ACCEPTED AND AGREED:	
 	

 
	
 Patrick D. Spangler	
 	

 
	
 /s/ Patrick D. Spangler






  Signature	
 	

 
	
 January 28, 2011






  Date	
 	

 
	
 10-4-2010






  Start Date	
 	

 
	
 Enclosure:        Confidentiality Agreement