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| Page 1 of 6 |
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|    |                                                                                                                |
|---------|---------------------------------------------------------------------------------------------------------------------|
| ● | Addition of Project Meetings, Teleconferences and Face to Face meetings with Sponsor.                               |
| ● | Addition of Client Database Review.                                                                                 |
| ● | Additional Statistical Analysis Plan (SAP) includes Text and Table and Listing Shells.                              |
| ● | Removal of Identifying Protocol Deviations and Analysis populations.                                                |
| ● | Additional Analysis Datasets, Specification, Programming and Quality Control.                                       |
| ● | Reduction in Production of Tables & Listings (Lost or redundant programming due to closure of HSG involvement). |
| ● | Removal of Statistical Analysis                                                                                     |
| ● | Removal of Input to Final report                                                                                    |
| ● | Removal of Unit based Data Management Costs for Program consistency checks and raising manual data queries.         |
| ● | Removal of Clinical Study Report (CSR).                                                                             |
| ● | Removal of Quality Assurance (QA) Site Audits.                                                                      |

|                                                 |
|------------------------------------------------------|
| INCResearch Australia Pty Limited - 1002213          |
| Prana (PBT2-203) Change Order #1, v4, 4th March 2014 |

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|                 |            |             |               |            |
|----------------------|-----------------|------------------|--------------------|-----------------|
|                 | Effective Date  | Direct CostsAUD$ | Indirect CostsAUD$ | Grand TotalAUD$ |
| Original Contract    | 28th March 2013 | $173,754.00      | $2,310.00          | $176,064.00     |
| Change Order # 1     | Upon Execution  | $53,809.00       | $0.00              | $53,809.00      |
| Total Contract Value |            | $227,563.00      | 2,310.00           | $229,873.00     |

|                        |   |                              |
|-----------------------------|--------|-----------------------------------|
| Prana Biotechnology Limited |   | INCResearch Australia Pty Limited |
|                             |   |                              |
| Signature By:               |   | Signature By:                     |
|                        |   |                              |
| DIANNE ANGUS                |   |                              |
| Name (print)                |   | Name (print)                      |
|                        |   |                              |
| Chief Operating Officer     |   |                              |
| Title                       |   | Title                             |
|                        |   |                              |
| 11 March 2014               |   |                              |
| Date                        |   | Date                              |

|                                                 |   |   |
|------------------------------------------------------|--------|--------|
| INCResearch Australia Pty Limited - 1002213          |   |   |
| Prana (PBT2-203) Change Order #1, v4, 4th March 2014 | 2      |   |

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|   |
|--------|
|        |

|                                   |   |                                                                                                                                            |   |               |            |          |                   |               |             |         |   |
|----------------------------------------|--------|-------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------------------|-----------------|---------------|------------------------|--------------------|------------------|--------------|--------|
| Service/Item                           |   | Comments                                                                                                                                        |   | Responsibility     | Unit            | UnitCost(AUD) | OriginalNumberof Units | CO#1Numberof Units | OriginalItemCost | CO#1ItemCost | AUD$   |
| Data Management& Statistics        |   |                                                                                                                                            |   |               |            |          |                   |               |             |         |   |
| Project familiarization                |   | Arrange test data extract from database, assess data structure and data quality. Receive final transfer from HSC.                               |   | ClinicalProgrammer | 1hr             | 108           | 16.00                  | 0.00               | 1,728            | 0            |   |
| Project Meetings                       |   | Teleconference and face to face meetings with Prana, CTCC and key opinion leaders                                                               |   | Statistician       | 10hr/week       | 2120          | 0.00                   | 26.00              | 0                | 55,120       |   |
| HSG Meeting (USA)                      |   | Three days of meetings plus travel time. (Jan Steyn or Melanie Bailey Tippetts and Peter Fursdon). Travel & accommodation arranged by Prana |   |               | 40hrs perperson | 8000          | 2.00                   | 0.00               | 16,000           | 0            |   |
| Database design                        |   | Review annotated CRF and database specification documentations                                                                                  |   | ClinicalProgrammer | 0.5hr/dataset   | 30            | 25.00                  | 0.00               | 750              | 0            |   |
| Data Validation Manual                 |   | Review DVM text/data management plan specifying edit checks                                                                                     |   | CDA                | 40hrs           | 104           | 16.00                  | 0.00               | 1,664            | 0            |   |
| Import BM, PK, ECG and immunology data |   | Electronic transfer of Biomarker, PK, ECG and MRI data (Data transfer plans, test transfers & final transfer)                               |   | DBA                | 1 study         | 1122          | 4.00                   | 0.00               | 4,488            | 0            |   |

|                                                 |   |   |
|------------------------------------------------------|--------|--------|
| INCResearch Australia Pty Limited - 1002213          |   |   |
| Prana (PBT2-203) Change Order #1, v4, 4th March 2014 | 3      |   |

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|                                |
|-------------------------------------|
| TW3.05C                             |
| Version 04                          |
| INC Research, LLC Change Order Form |
|                                | Service/Item |   |   | Comments |   | Responsibility | Unit | UnitCost(AUD) | OriginalNumberof Units | CO#1Numberof Units | OriginalItemCost | CO#1ItemCost | AUD$ |
|                                | Client Database Review |   |   | Database Report prepared by Karen Reynolds |   | DM Systems | 40hrs | 7400 | 0.00 | 1.00 | 0 | 7,400 |   |
|                                | Statistical Analysis Plan (SAP) |   |   | Includes text and table and listing shells |   | Statistician | 1 SAP | 9426 | 1.00 | 0.00 | 9,426 | 0 |   |
|                                | Statistical Analysis Plan (SAP) |   |   | Additional text and table and listing shells |   | Statistician | 1 SAP | 13936 | 0.00 | 1.00 | 0 | 13,936 |   |
|                                | Statistical Analysis Plan (SAP) |   |   | SAP Amendment 1 (24 hours) |   | Statistician | 1 SAP | 5088 | 0.00 | 1.00 | 0 | 5,088 |   |
|                                | Identify Protocol Deviations and define Analysis populations |   |   | Unblinding, Protocol deviations and Definition of populations |   | Statistician | 1 study | 1600 | 1.00 | -1.00 | 1,600 | -1,600 |   |
|                                | Analysis Datasets |   |   | Specification, Programming & QC |   | SASProgrammer | 1 study | 21294 | 1.00 | 0.00 | 21,294 | 0 |   |
|                                | Data Cleaning Issues |   |   | Resolving data issues in CTCC data sets |   | SASProgrammer | per hour | 169 | 0.00 | 400.00 | 0 | 67,600 |   |
|                                | Production of Tables & Listings |   |   | 14 Unique tables. Cost per extra $1014 20 Repeat tables. Cost per extra $33836 Figures. Cost per extra $592 38 Listings. Cost per extra $422 |   | SASProgrammer | 1 study | 52221 | 1.00 | 0.00 | 52,221 | 0 |   |
|                                | Production of Tables & Listings (Lost or redundant programming due to closure of HSG involvement) |   |   | Primary programming lost: 20 analyses programs lost @ $212, 19 unique tables lost @$507, 68 tables requiring modification @ $126.75, 51 Listings requring minor modification @ $84.50. |   | SASProgrammer | 1 study | 29152 | 0.00 | -1.00 | 0 | -29,152 |   |

| INC Research, LLC – CONFIDENTIAL               |
|------------------------------------------------------|
|                                                 |   |   |
| INCResearch Australia Pty Limited - 1002213          |   |   |
| Prana (PBT2-203) Change Order #1, v4, 4th March 2014 | 4  |   |

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| TW3.05C                             |
|-------------------------------------|
| Version 04                          |
| INC Research, LLC Change Order Form |
|                                | Service/Item |   |   | Comments |   | Responsibility | Unit | UnitCost(AUD) | Original Number of Units | CO#1 Number of Units | Original Item Cost | CO#1 Item Cost | AUD$ |   |
|                                | Statistical Analysis |   |   | Analysis endpoints. Cost per extra $424 |   | Statistician | 1 analysis endpoint | 424 | 19.00 | -19.00 | 8,056 | -8,056 |   |   |
|                                | Input to Final report |   |   | Text for inclusion in study report |   | Statistician | 1 Study | 5088 | 1.00 | -1.00 | 5,088 | -5,088 |   |   |
|                                | Unit based Data Management Costs |   |   | Program consistency check |   | Clinical Programmer | 1 check | 60 | 1.00 | -1.00 | 60 | -60 |   |   |
|                                | Unit based Data Management Costs |   |   | Raise manual data query |   | CDA | 1 query | 52 | 1.00 | -1.00 | 52 | -52 |   |   |
|                                |   |   |   |   |   |   |   |   |   | Subtotal | 122,427 | 105,136 | $227,563 |   |
|                                | Medical Writing |   |   |   |   |   |   |   |   |   |   |   |   |   |
|                                | Clinical Study Report (CSR) |   |   |   |   | Medical Writer | per CSR | 25418 | 1.00 | -1.00 | 25,418 | -25,418 |   |   |
|                                |   |   |   |   |   |   |   |   |   | Subtotal | 25,418 | -25,418 | $0 |   |
|                                | Quality Assurance - Site Audits |   |   |   |   |   |   |   |   |   |   |   |   |   |
|                                | Quality Assurance Site Audits |   |   | GCP Audits preparation time |   | QAA | Site Audit | 1314 | 2.00 | -2.00 | 2,628 | -2,628 |   |   |
|                                |   |   |   | GCP Audits on-site |   | QAA | Site Audit | 2628 | 2.00 | -2.00 | 5,255 | -5,255 |   |   |
|                                |   |   |   | GCP Audits report preparation |   | QAA | Site Audit | 1971 | 2.00 | -2.00 | 3,941 | -3,941 |   |   |
|                                |   |   |   | GCP Audits travel time |   | QAA | Site Audit | 1570 | 2.00 | -2.00 | 3,140 | -3,140 |   |   |
|                                |   |   |   | Review of Audit reports |   | QAA | Site Audit | 443 | 2.00 | -2.00 | 886 | -886 |   |   |
|                                | QA Audit of Vendor(s) |   |   |   |   | QAA | Audit | 10059 | 1.00 | -1.00 | 10,059 | -10,059 |   |   |
|                                |   |   |   |   |   |   |   |   |   | Subtotal | 25,909 | -25,909 | $0 |   |
|                                |   |   |   |   |   |   |   |   |   |   |   |   |   |   |
|                                |   |   |   |   |   |   |   |   |   | TOTAL | 173,754 | 53,809 | $227,563 |   |

| INC Research, LLC – CONFIDENTIAL |
|----------------------------------------|
| INCResearch Australia Pty Limited - 1002213          |   |   |
|------------------------------------------------------|--------|--------|
| Prana (PBT2-203) Change Order #1, v4, 4th March 2014 | 5      |   |

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|                                   |
|----------------------------------------|
| TW3.05C                                |
| Version 04                             |
| INC Research, LLC Change Order Form    |
|                                   |
| Pass-Through Costs – NIL changes |

|   | Expense/Item                              |   | Comments | Unit Cost (AUD) | OriginalNumberof Units | CO#1Number of Units | OriginalItem CostAUD$ | CO#1ItemCostAUD$ | AUD$   |
|--------|-------------------------------------------|--------|----------|-----------------|------------------------|---------------------|-----------------------|------------------|--------|
|   | Site Visits                               |   |     |            |                   |                |                  |             |   |
|   | Travel Costs(flights/accommodation/taxis) |   |     | $1,155/visit    | 2                      | 0                   | 2,310                 | 0                |   |
|   |                                      |   |     |            |                   | Subtotal            | 2,310                 | 0                | $2,310 |
|   |                                      |   |     |            |                   |                |                  |             |   |
|   |                                      |   |     |            |                   | TOTAL               | 2,310                 | 0                | $2,310 |

| INC Research, LLC - CONFIDENTIAL |
|----------------------------------|
| INCResearch Australia Pty Limited - 1002213          |   |   |
|------------------------------------------------------|--------|--------|
| Prana (PBT2-203) Change Order #1, v4, 4th March 2014 | 6      |   |

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