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CERTIFICATION

I, Albert D. Friesen, certify that:

1. I have reviewed
  this annual report on Form 20-F of Medicure Inc.;

2. Based on my
  knowledge, this report does not contain any untrue statement of a material fact
  or omit to state a material fact necessary to make the statements made, in light
  of the circumstances under which such statements were made, not misleading with
  respect to the period covered by this report;

3. Based on my
  knowledge, the financial statements, and other financial information included
  in this report, fairly present in all material respects the financial condition,
  results of operations and cash flows of the company as of, and for, the periods
  presented in this report;

4. The company's
  other certifying officer(s) and I are responsible for establishing and maintaining
  disclosure controls and procedures (as defined in Exchange Act Rules 13a-15(e)
  and 15d-15(e)) for the company and have:

| | (a) | Designed such disclosure controls and procedures, or caused such disclosure
      controls and procedures to be designed under our supervision, to ensure
      that material information relating to the company, including its consolidated
      subsidiaries, is made known to us by others within those entities, particularly
      during the period in which this report is being prepared;
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|
| | (b) | Evaluated the effectiveness of the company's disclosure controls and
      procedures and presented in this report our conclusions about the effectiveness
      of the disclosure controls and procedures, as of the end of the period covered
      by this report based on such evaluation; and                                                                                                 
|
| | (c) | Disclosed in this report any change in the company's internal control
      over financial reporting that occurred during the period covered by the
      annual report that has materially affected, or is reasonably likely to materially
      affect, the company's internal control over financial reporting; and                                                                             

5. The company's
  other certifying officer(s) and I have disclosed, based on our most recent evaluation
  of internal control over financial reporting, to the company's auditors and
  the audit committee of the company's board of directors (or persons performing
  the equivalent functions):

| | (a) | All significant deficiencies and material weaknesses in the design or
      operation of internal control over financial reporting which are reasonably
      likely to adversely affect the company's ability to record, process, summarize
      and report financial information; and
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|
| | (b) | Any fraud, whether or not material, that involves management or other
      employees who have a significant role in the company's internal control
      over financial reporting.                                                                                                     

|Date: | August 19, 2005 | /s/ Albert D. Friesen        
|----- | --------------- | -----------------------------
|      |                 | Chief Executive Officer      
|      |                 | (Principal Executive Officer)

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