Exhibit 10.245

FIFTH AMENDMENT TO LOAN AGREEMENT

THIS FIFTH AMENDMENT TO LOAN AGREEMENT (the Amendment),
dated as of July 1, 2007, is made by and among PHARMACEUTICAL PRODUCT DEVELOPMENT, INC. (the Borrower), PPD DEVELOPMENT, LP, (the Guarantor) and BANK OF AMERICA, N.A. (the Bank).

RECITALS:

A. The Borrower, the Guarantor and the
Bank entered into that certain Loan Agreement, dated as of July 25, 2002, as amended (the Loan Agreement).

B. The
Borrower, the Guarantor and the Bank have agreed to amend the Loan Agreement as set forth herein.

NOW THEREFORE, the parties hereto agree
as follows:

1. Section 1.01 of the Loan Agreement is amended by deleting the definition of Termination Date and replacing
it with the following definition:

Termination Date means June 30, 2008, or such later date as to which the
Bank may agree in its sole discretion.

2. Except as hereby modified, all the terms and provisions of the Loan Agreement and exhibits
thereto remain in full force and effect.

3. The Borrower and the Guarantor acknowledge and agree that there are no defenses, setoffs or
counterclaims available to them with respect to the performance of their obligations under the Loan Agreement (including, without limitation, the Guarantors obligations under Section 3 of the Loan Agreement).

4. The Borrower and the Guarantor will execute such additional documents as are reasonably requested by the Bank to reflect the terms and conditions of
this Amendment and will cause to be delivered such certificates, legal opinions and other documents as are reasonably required by the Bank. In addition, the Borrower and the Guarantor will pay all costs and expenses in connection with the
preparation, execution and delivery of the documents executed in connection with this transaction, including, without limitation, the reasonable fees and out-of-pocket expenses of special counsel to the Bank as well as any and all filing and
recording fees and stamp and other taxes with respect thereto and to save the Bank harmless from any and all such costs, expenses and liabilities.



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5. This Amendment may be executed in any number of counterparts, each of which when so executed and
delivered shall be deemed an original, and it shall not be necessary in making proof of this Amendment to produce or account for more than one counterpart.

6. This Amendment and all other documents executed pursuant to the transactions contemplated herein shall be deemed to be contracts made under, and for all purposes shall be construed in accordance with, the internal
laws and judicial decisions of the State of North Carolina. The Borrower and the Guarantor hereby submit to the jurisdiction and venue of the state and federal courts of North Carolina for the purposes of resolving disputes hereunder and thereunder
or for purposes of collection.

IN WITNESS WHEREOF, the parties hereto have caused this Amendment to be executed by their fully authorized
officers as of the day and year first above written.



|           |  |                                                                        |  |                        
|---------- |  | ---------------------------------------------------------------------- |  | -----------------------
|BORROWER:  |  | PHARMACEUTICAL PRODUCT DEVELOPMENT, INC., a North Carolina corporation
|           |  |                                                                       
|           |  | By:                                                                    |  | /s/ Fredric N. Eshelman
|           |  | Name:                                                                  |  | Fredric N. Eshelman    
|           |  | Title:                                                                 |  | CEO                    
|           | 
|GUARANTOR: |  | PPD DEVELOPMENT, LP, a Texas limited
partnership                      



| |  |  |  |                                       |  |                        
| |  |  |  | ------------------------------------- |  | -----------------------
| |  | 
| |  |  |  | By: PPD GP, LLC,                     
| |  |  |  | a Delaware limited liability company,
| |  |  |  | its General Partner                  
| |  |  | 
| |  |  |  | By:                                   |  | /s/ Fredric N. Eshelman
| |  |  |  | Name:                                 |  | Fredric N. Eshelman    
| |  |  |  | Title:                                |  | CEO                    



|      |  |                       |  |                           
|----- |  | --------------------- |  | --------------------------
|      | 
|BANK: |  | BANK OF AMERICA, N.A.
|      |  |                      
|      |  | By:                   |  | /s/ J. Thomas Johnson, Jr.
|      |  | Name:                 |  | J. Thomas Johnson, Jr.    
|      |  | Title:                |  | Sr. Vice President