STATE OF NORTH CAROLINA

COUNTY OF NEW HANOVER

                               AMENDMENT TO LEASE
                               ------------------

         THIS AMENDMENT TO LEASE AGREEMENT, entered into as of this _14th day of
April, 1999, by and between BBC FAMILY LIMITED PARTNERSHIP, a North Carolina
limited partnership, whose address is 1201 Glen Meade Road, Wilmington, N. C.
28401 ("Lessor"), and PPD PHARMACO INC., a corporation, whose address is 3151
South 17th Street, Wilmington, NC 28412, ("Lessee");

                              W I T N E S S E T H :
                              ---------------------

         THAT, WHEREAS, by lease agreement entered into as of September 15,
1998, Lessor leased certain premises in New Hanover County, North Carolina, to
Lessee; and

         WHEREAS, the parties hereto desire to amend the said Lease Agreement to
correct an error in the legal description of the leased premises;

         NOW, THEREFORE, for valuable consideration received by each of the
parties hereto, from the other, the receipt and legal sufficiency of which is
hereby acknowledged, it is agreed that the aforesaid Lease Agreement is amended
as follows:

1.       THE DESCRIPTION OF REAL PROPERTY INSERTED IN THE LEASE AGREEMENT IS
         HEREBY AMENDED BY DELETING THE SAME IN ITS ENTIRETY AND INSERTING IN
         LIEU THEREOF EXHIBIT "A" ATTACHED HERETO.

         All other terms and conditions of the said Lease Agreement shall remain
in full force and effect except as amended or modified hereby or inconsistent
herewith.

         IN WITNESS WHEREOF, BBC FAMILY LIMITED PARTNERSHIP has caused this
instrument to be executed under seal in its partnership name by all of its
General Partners, and PPD PHARMACO INC. has caused this instrument to be
executed by its Vice- President, attested by its ______________ Secretary, and
its corporate seal to be hereunto affixed, all by authority of its Board of
Directors duly given.
<PAGE>
                                   BBC FAMILY LIMITED PARTNERSHIP  (SEAL)

                                   By /s/ Scott C. Sullivan  (SEAL)
                                     ----------------------
                                        Scott C. Sullivan
                                        General Partner

                                   By /s/ Jabe V. Hardee  (SEAL)
                                     -------------------
                                        Jabe V. Hardee
                                        General Partner

                                   PPD PHARMACO INC.
ATTEST:
                                   By: /s/ Rudy C. Howard
                                       ------------------
                                     Rudy C. Howard Vice- President
/s/ Fred B. Davenport, Jr.
--------------------------
Fred B. Davenport, Jr. Secretary
--------------------------------
<PAGE>
STATE OF NORTH CAROLINA

COUNTY OF NEW HANOVER

         I, Kimberly Ameri, a Notary Public of New Hanover County, North
Carolina, do hereby certify that SCOTT C. SULLIVAN, and JABE V. HARDEE, the
General Partners of BBC FAMILY LIMITED PARTNERSHIP, a limited partnership,
personally appeared before me this day and acknowledged the due execution of the
foregoing instrument.

         Witness my hand and notarial seal, this the 14th day of April, 1999.

                                             /s/ Kimberly Ameri
                                             ----------------------------
                                               Notary Public

My commission expires: 3-15-2003

STATE OF NORTH CAROLINA

COUNTY OF NEW HANOVER

         I, Jean G. Wachtel, a Notary Public of New Hanover County, North
Carolina, do hereby certify that __________ Fred B. Davenport, Jr. personally
appeared before me this day and acknowledged that he (or she) is the
_____________ Secretary of PPD PHARMACO INC., a corporation; that the foregoing
and annexed instrument was signed in the name of the corporation by its
Vice-President, attested by himself (or herself) as its _______________
Secretary, and its corporate seal thereunto affixed, all by authority of its
Board of Directors duly given.

         Witness my hand and notarial seal, this the 14th day of April, 1999.

                                            /s/ Jean G. Wachtel
                                            --------------------------
                                                Notary Public

My commission expires: June 23, 2003