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CERTIFICATION

I, Albert D. Friesen, certify that:

1.         I
  have reviewed this annual report on Form 20-F of Medicure Inc.;

2.        Based
  on my knowledge, this report does not contain any untrue statement of a material
  fact or omit to state a material fact necessary to make the statements made,
  in light of the circumstances under which such statements were made, not misleading
  with respect to the period covered by this report;

3.        Based
  on my knowledge, the financial statements, and other financial information included
  in this report, fairly present in all material respects the financial condition,
  results of operations and cash flows of the company as of, and for, the periods
  presented in this report;

4.        The
  company's other certifying officer(s) and I are responsible for establishing
  and maintaining disclosure controls and procedures (as defined in Exchange Act
  Rules 13a-15(e) and 15d-15(e)) for the company and have:

| | (a) | Designed such disclosure controls and procedures,
        or caused such disclosure controls and procedures to be designed under
        our supervision, to ensure that material information relating to the company,
        including its consolidated subsidiaries, is made known to us by others
        within those entities, particularly during the period in which this report
        is being prepared;
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| |     |                                                                                                                                                                                                                                                                                                                                                                                                                    
| | (b) | Omitted;                                                                                                                                                                                                                                                                                                                                                                                                           
| |     |                                                                                                                                                                                                                                                                                                                                                                                                                    
| | (c) | Evaluated the effectiveness of the company's
        disclosure controls and procedures and presented in this report our conclusions
        about the effectiveness of the disclosure controls and procedures, as
        of the end of the period covered by this report based on such evaluation;
        and                                                                                                   
| |     |                                                                                                                                                                                                                                                                                                                                                                                                                    
| | (d) | Disclosed in this report any change in
        the company's internal control over financial reporting that occurred
        during the period covered by the annual report that has materially affected,
        or is reasonably likely to materially affect, the company's internal control
        over financial reporting; and                                                                               

5.        The
  company's other certifying officer(s) and I have disclosed, based on our most
  recent evaluation of internal control over financial reporting, to the company's
  auditors and the audit committee of the company's board of directors (or persons
  performing the equivalent functions):

| | (a) | All significant deficiencies and material weaknesses
        in the design or operation of internal control over financial reporting
        which are reasonably likely to adversely affect the company's ability
        to record, process, summarize and report financial information; and
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| |     |                                                                                                                                                                                                                                                                                               
| | (b) | Any fraud, whether or not material, that involves management or other
      employees who have a significant role in the company's internal control
      over financial reporting.                                                                                                           

|Date: October 7, 2003 | /s/ Albert D. Friesen        
|--------------------- | -----------------------------
|                      | Chief Executive Officer      
|                      | (Principal Executive Officer)

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