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CERTIFICATION

I, Albert D. Friesen, certify that:

|1. | I have reviewed
        this annual report on Form 20-F of Medicure Inc.;                                                                                                                                                                                                                                                                 
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|2. | Based on my
        knowledge, this report does not contain any untrue statement of a material
        fact or omit to state a material fact necessary to make the statements
        made, in light of the circumstances under which such statements were made,
        not misleading with respect to the period covered by this report;
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|3. | Based on my
        knowledge, the financial statements, and other financial information included
        in this report, fairly present in all material respects the financial
        condition, results of operations and cash flows of the company as of,
        and for, the periods presented in this report;                      
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|4. | The company's
        other certifying officer(s) and I are responsible for establishing and
        maintaining disclosure controls and procedures (as defined in Exchange
        Act Rules 13a-15(e) and 15d-15(e)) for the company and have:                                                                                          
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|   | (a)                                                                                                                                                                                                                                                                                                                                       
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|   | (b)                                                                                                                                                                                                                                                                                                                                       
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|   | (c)                                                                                                                                                                                                                                                                                                                                       
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|5. | The company's
        other certifying officer(s) and I have disclosed, based on our most recent
        evaluation of internal control over financial reporting, to the company's
        auditors and the audit committee of the company's board of directors (or
        persons performing the equivalent functions):                 
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|   | (a)                                                                                                                                                                                                                                                                                                                                       
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|   | (b)                                                                                                                                                                                                                                                                                                                                       

|Date: September 10, 2004 | /s/ Albert D. Friesen         | 
|------------------------ | ----------------------------- | 
|                         | Chief Executive Officer       | 
|                         | (Principal Executive Officer) | 

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