Emamectin benzoate 

PC Code: 122806 

Dietary Exposure and Risk Assessment DP Number: 0393838 

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

OFFICE OF CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

MEMORANDUM 

Date: 19-DEC-2012 

SUBJECT: Emamectin Benzoate: Revised Acute and Chronic Aggregate Dietary 

(Food and Drinking Water) Exposure and Risk Assessments for the 

Section 3 Registration Action on Cucurbits and Outdoor-Grown Plants in 

Commercial Nursery Production 

PC Code: 122806 

Decision No.: 452138 

Petition No.: IE7904 

DP Barcode: D393838 

Registration Nos.: 100-904, 100-RURR 

Regulatory Action: Section 3 Registration 

Risk Assessment Type: NA Case No.: NA 

TXRNo.: NA CAS No.: 155569-91-8 (emamectin benzoate) 

119791-4 I-2 ( emamectin) 

MRIDNo.:NA 40 CFR: § 180.505 

FROM: Nancy Dodd, Chemist -; d~ A -~Ce..// 

Risk Assessment Branch III (RAB3) 

Health Effects Division (HED; 7509P) 

< 

THROUGH: Julie 

Sheila 

L. 

Piper

Van 

, 

Alstine, 

Chemist 

MP

$"~ 

H, Enviro

l.Ji~ 

ental Health Scientist ~ 

Dietary Exposure Science Advisory Council (DESAC) 

HED (7509P) 

and 

Jeff Dawson, Acting Branch Chief 

RAB31HED (7509P) 

TO: Barbara Madden/ Andrew Ertman, RM#5 

Registration Division (RD; 7505P) 

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Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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Executive Summary

Acute and chronic aggregate dietary (food and drinking water) exposure and risk 

assessments were conducted using the Dietary Exposure Evaluation Model software with 

the Food Commodity Intake Database (DEEM-FCID), Version 3.16. This software uses 

2003-2008 food consumption data from the U.S. Department of Agriculture’s (USDA’s) 

National Health and Nutrition Examination Survey, What We Eat in America 

(NHANES/WWEIA). The analyses were conducted in support of a human health risk 

assessment for the proposed Section 3 use of emamectin benzoate on cucurbits. This 

memorandum was reviewed by two peer reviewers of the DESAC, per the current 

DESAC Standard Operating Procedure (SOP). 

 

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization

A probabilistic acute dietary exposure assessment was conducted. The anticipated 

residue estimates, used for most crops, were based on field trial data. Tolerance-level 

residues were used for tree nuts (including pistachios) and cottonseed oil. Pesticide Data 

Program (PDP) monitoring data for years 2009 and 2010 were used for apples since apple 

juice had a significant impact on exposure. DEEM default processing factors were used 

except for commodities with chemical-specific processing studies. Percent crop treated 

(% CT) data and percent crop treated data for new crops (PCTn) provided by the 

Biological and Economic Analysis Division (BEAD) in 2012 were used. The estimated 

drinking water concentrations (EDWCs) of emamectin benzoate were provided by the 

Environmental Fate and Effects Division (EFED). A drinking water residue distribution 

based on the Pesticide Root Zone Model/Exposure Analysis Modeling System 

(PRZM/EXAMS) modeling of the use on ornamentals was used in the acute assessment. 

The acute dietary exposure estimates for food and drinking water using the ornamentals 

scenario for drinking water are below HED’s level of concern at the 99.9th percentile of 

exposure for all population subgroups (36% of the aPAD for the general U.S. population 

and 60% of the aPAD for children 1-2 years old). 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization

A somewhat refined chronic dietary exposure assessment was conducted. The 

anticipated residue estimates, used for most crops, were single point estimates (averages) 

based on field trial data. Tolerance-level residues were used for tree nuts (including 

pistachios) and cottonseed oil. DEEM default processing factors were used except for 

commodities with chemical-specific processing studies. Percent crop treated data and 

PCTn data provided by BEAD in 2012 were used. The EDWC of 0.150 μg/L (ppb) for 

the chronic exposure was based on PRZM/EXAMS modeling of the use on ornamentals, 

which resulted in the highest chronic EDWC considering all proposed/registered uses. 

The chronic dietary exposure estimates for food and drinking water using the ornamentals 

scenario for drinking water are below HED’s level of concern for all population 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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subgroups (7.5% of the cPAD for the general U.S. population and 16% of the cPAD for 

all infants less than 1 year old). 

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization

Emamectin benzoate is classified as “not likely to be carcinogenic to humans” based on 

the rodent carcinogenicity studies. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For 

acute and chronic assessments, the risk is expressed as a percentage of a maximum 

acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable 

adverse health effects). This dose is referred to as the population adjusted dose (PAD). 

The PAD is equivalent to point of departure (POD, NOAEL, LOAEL, e.g.) divided by 

the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary 

risk exceeds 100% of the PAD. References which discuss the acute and chronic risk 

assessments in more detail are available on the EPA/pesticides web site: “Available 

Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, 

web link: http://www.epa.gov/fedrgstr/EPA-PEST/2000/July/Day-12/6061.pdf; or see 

SOP 99.6 (20-AUG-1999). 

This revised assessment uses DEEM Version 3.16; the previous assessment (N. Dodd, 

DP No. D393838, 8/29/12) used the older DEEM Version 2.03. Other than the 8/29/12 

memo, the most recent dietary risk assessment for emamectin benzoate was conducted by 

Nancy Dodd (24-JUL-2008, D347924 and addendum 22-JAN-2009, D360696). 

II. Residue Information

Tolerances: Tolerances for plant commodities have been established under 40 CFR 

§180.505(a)(1) for the combined residues of emamectin (a mixture of a minimum of 90% 

4'-epi-methylamino-4'-deoxyavermectin B1a and maximum of 10% 4'-epi-methylamino4'-deoxyavermectin B1b) and its metabolites 8,9-isomer of the B1a and B1b component of 

the parent (8,9-ZMA), or 4'-deoxy-4'-epi-amino-avermectin B1a and 4'-deoxy-4'-epiamino-avermectin B1b; 4'-deoxy-4'-epi-amino-avermectin B1a (AB1a); 4'-deoxy-4'-epi-(Nformyl-N-methyl)amino-avermectin (MFB1a); and 4'-deoxy-4'-epi-(N-formyl)aminoavermectin B1a (FAB1a) at levels ranging from 0.02 ppm to 0.20 ppm. 

Tolerances for livestock commodities have been established under 40 CFR 

§180.505(a)(2) for the combined residues of emamectin (MAB1a + MAB1b isomers) and 

the associated 8,9-Z isomers (8,9-ZB1a + 8,9-ZB1b). The established tolerance levels are 

0.010 ppm for the fat of cattle, goat, horse, and sheep; 0.050 ppm for the liver of cattle, 

goat, horse, and sheep; 0.003 ppm for the meat of cattle, goat, horse, and sheep; 0.020 

ppm for the meat byproducts except liver of cattle, goat, horse, and sheep; 0.003 ppm for 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

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hog fat; 0.020 ppm for hog liver; 0.002 ppm for hog meat; 0.005 ppm for hog meat 

byproducts except liver; and 0.003 ppm for milk. No tolerances have been established for 

poultry commodities. 

Residues of Concern: The residues of concern in plants for the tolerance expression and 

dietary risk assessment are emamectin (MAB1a + MAB1b), the associated 8,9-Z isomers 

(8,9-ZB1a + 8,9-ZB1b), and metabolites/degradates AB1a, MFB1a, and FAB1a. For 

ruminant commodities, emamectin (MAB1a + MAB1b) and its 8,9-Z isomers (8,9-ZB1a + 

8,9-ZB1b) are included in the tolerance expression and dietary risk assessment. 

Residues in Crops: 

Acute assessment: A probabilistic acute dietary exposure assessment was conducted. 

The anticipated residue estimates, used for most crops, were based on field trial data. 

The anticipated residues for the cucurbits subgroup 9A are shown in Table 1 below. The 

maximum residue for cantaloupe (0.0046 ppm) was used for the cucurbits subgroup 9A 

(HED Standard Operating Procedures 2000.1, 9/12/2000). Anticipated residues for the 

cucurbits subgroup 9B were based on the LOD’s for cucumber (0.004 ppm) and squash 

(0.0061 ppm). Tolerance-level residues were used for tree nuts (including pistachios) and 

cottonseed oil. Pesticide Data Program (PDP) monitoring data for years 2009 and 2010 

were used for apples since apple juice had a significant impact on exposure. DEEM 

default processing factors were used except for commodities with chemical-specific 

processing studies. Percent crop treated data and PCTn data provided by the BEAD in 

2012 were used. 

 

Chronic assessment: A somewhat refined chronic dietary exposure assessment was 

conducted. The anticipated residue estimates, used for most crops, were single point 

estimates (averages) based on field trial data. The anticipated residues for cucurbits 

subgroup 9A are shown in Table 1 below. The average residue for cantaloupe (0.0032 

ppm) was used for the cucurbits subgroup 9A (HED Standard Operating Procedures 

2000.1, 9/12/2000). Anticipated residues for the cucurbits subgroup 9B were based on 

the LODs for cucumber (0.004 ppm) and squash (0.0061 ppm). Tolerance-level residues 

were used for tree nuts (including pistachios) and cottonseed oil. DEEM default 

processing factors were used except for commodities with chemical-specific processing 

studies. Percent crop treated data and PCTn data provided by BEAD in 2012 were used. 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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Table 1. Emamectin Benzoate Anticipated Residues for Cucurbits Subgroup 9A 

No. of 

Trials 

Residues (ppm)1 

MAB1a MAB1b 8,9-Z 

isomers 

AB1a MFB1a FAB1a Combined 

residues2

Cantaloupe 4 0.0005 0.0005 0.0005 0.0005 0.0005 0.0005 0.0030 

1 0.0011 0.0005 0.0005 0.0005 0.0005 0.0005 0.0036 

1 0.0015 0.0005 0.0005 0.0005 0.0005 0.0005 0.0040 

1 0.0012 0.0005 0.0005 0.0005 0.0005 0.0005 0.0037 

1 0.00075 0.0005 0.0005 0.0005 0.0005 0.0005 0.0032 

1 0.0026 0.0005 0.0005 0.0005 0.0005 0.0005 0.0051 

1 0.0012 0.0005 0.0005 0.0005 0.0005 0.0005 0.0037 1 The LOQ was 0.001 ppm for each analyte. Per-trial averages were calculated using the 1⁄2 LOQ for all 

residues reported as <LOQ. 

2

 Combined residues include total emamectin (MAB1a and MAB1b), its 8,9-Z isomers (8,9-ZB1a and 8,9-

ZB1b), and metabolites/degradates AB1a, MFB1a, and FAB1a. The average is 0.0035 ppm. 

Pesticide Data Program (PDP) monitoring data for apples were used in the acute 

assessment since apple juice has a significant impact on exposure. The total number of 

apple samples from years 2009 and 2010 was 1278 with no detects at a limit of detection 

of 0.001 ppm. 

Processed Commodities: Processing studies are available on apples (MRID 45899801), 

tomatoes (MRID 46587002), and cottonseed (MRID 44883716). The studies show that 

residues do not concentrate in apple juice, tomato paste, tomato puree, and cottonseed oil; 

therefore, a processing factor of 1.0x is used for these commodities. The apple juice 

result is translated to pear juice (1.0x). DEEM default processing factors are applied to 

other processed commodities: apples, dried (8.0x); pears, dried (6.25x); tomato juice 

(1.5x); tomato, dried (14.3x); and beef, meat, dried (1.92x). 

Meat, Milk, Poultry, and Eggs: Residues in livestock commodities are based on the 

livestock dietary burdens from Table 2 and the feeding study results from Table 3. 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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Table 2. Livestock Maximum Reasonable Dietary Burdens for Emamectin Benzoate1

 % Diet Dietary Contributions (ppm) 

Feedstuff Type Tolerance, 

ppm 

% Dry 

Matter 

Beef Dairy Poultry Swine Beef Dairy Poultry Swine 

Almond hulls R 0.0553 90 NU2 10 NU NU 0 0.0061 0 0 

Cotton gin 

byproducts 

R 0.050 90 5 NU NU NU 0.0028 0 0 0 

Cotton hulls R 0.025 90 10 NU NU NU 0.0028 0 0 0 

Untreated R 0 --- 0 35 0 0 0 0 0 0 

Apple 

pomace, wet 

CC 0.075 40 NU2 10 NU NU 0 0.019 0 0 

Untreated CC 0 -- 80 35 75 85 0 0 0 0 

Cotton meal PC 0.025 89 5 -- 20 15 0.0014 0 0.0056 0.0042 

Cotton, 

undelinted 

seed 

PC 0.025 88 NU 10 NU NU 0 0.0028 0 0 

Untreated PC 0 --- 0 0 5 0 0 0 0 0 

Totals 100 100 100 100 0.0070 0.028 0.0056 0.0042 1

 All data are based on Table 1 Feedstuffs (June 2008). Residue levels for beef and dairy cattle are 

corrected for moisture content and are determined by the following formula: tolerance ÷ % dry matter x % 

in diet. Residue levels for poultry and swine are considered “as-is” and are determined by the following 

formula: tolerance x % in diet. 

2

 NU = Not Used. 

3

 Almond hulls are partially blended. The average residue value (0.055 ppm from MRID 47243301) is 

used for dairy cattle feed items. The HAFT of 0.0985 ppm would be used for beef cattle, poultry, or swine. 

An adequate cattle feeding study was submitted in conjunction with a previous petition 

(PP#7F04845, D267346, M. Xue, 2/19/02). The maximum residues observed in cattle 

matrices at each of the dosing levels are presented in Table 3 below. The reported LODs 

and LOQs for each analyte were 0.001 and 0.002 ppm, respectively, in liver, kidney, 

muscle, and fat; 0.0001 and 0.0005 ppm, respectively, in milk (whole and skim); and 

0.00025 and 0.0005 ppm, respectively, in cream. 

Since all dietary burdens in Table 2 above are <0.03 ppm, the residues from the low dose 

(0.03 ppm) cattle feeding study were used in the dietary assessments as the residue levels 

in livestock commodities. Component residues used in the dietary assessment for whole 

milk and cream are bolded in Table 3 below. Component residues used for fat, kidney, 

liver, and meat (muscle) are also bolded. For residues reported as <LOD or <LOQ, 1⁄2 the 

LOD or 1⁄2 the LOQ was used to sum the component residues. The total residues used in 

the assessment were 0.003 ppm for fat, 0.0045 ppm for kidney, 0.01 ppm for liver, 0.002 

ppm for meat, and 0.01 ppm for meat byproducts of cattle, goat, hog, horse, and sheep; 

0.0003 ppm for milk, and 0.002 ppm for cream. No poultry commodity tolerances have 

been established. 

 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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Table 3. Maximum Residues Observed in Cattle Matrices in the Cattle Feeding Study2 

Matrix 

Low Dose (0.030 ppm) Mid Dose (0.090 ppm) High Dose (0.300 ppm) 

MAB1a + 

8,9-Z B1a

MAB1b + 

8,9-Z B1b

MAB1a + 

8,9-Z B1a

MAB1b + 

8,9-Z B1b

MAB1a + 

8,9-Z B1a

MAB1b + 

8,9-Z B1b

Whole milk <0.0005 <0.0001 0.0010 <0.0005 0.0053 0.0006 1

Skim milk <0.0005 <0.0001 0.0007 <0.0001 0.0030 <0.0005 

Cream 0.0021 <0.0001 0.0046 <0.0005 0.021 0.0017 1

Fat 0.0022 <0.001 0.0066 <0.002 0.015 <0.002 

Kidney 0.0040 <0.001 0.013 <0.001 0.042 0.0036 1

Liver 0.010 <0.001 0.029 0.0022 0.115 0.0090 1

Muscle <0.002 <0.001 0.0020 <0.001 0.0064 <0.001 

1

 This value represents the result for MAB1b + 8,9-Z B1b in the sample containing the maximum residues of 

MAB1a + 8,9-Z B1a. 2 Component residues used in the dietary assessment are bolded. For residues reported as <LOD or <LOQ, 

1⁄2 the LOD or 1⁄2 the LOQ was used to sum the component residues. 

Catfish/Fish: The USDA Pesticide Data Program (PDP) monitored pesticide residues in 

catfish/fish in 2008, 2009, and 2010; however, the samples were not analyzed for 

emamectin benzoate. As a result, residues in catfish/fish were not included in the 

assessment. 

Residue Data used for the Acute Dietary (Food + Drinking Water) Assessment:

A probabilistic acute dietary exposure assessment was conducted. The anticipated 

residue estimates, used for most crops, were based on field trial data. The anticipated 

residues for the cucurbits subgroup 9A are shown in Table 1 above. The maximum 

residue for cantaloupe (0.0051 ppm) was used for the cucurbits subgroup 9A (HED 

Standard Operating Procedures 2000.1, 9/12/2000). Anticipated residues for the 

cucurbits subgroup 9B were based on the LOD’s for cucumber (0.004 ppm) and squash 

(0.0061 ppm). Tolerance-level residues were used for tree nuts (including pistachios) and 

cottonseed oil. Pesticide Data Program (PDP) monitoring data for years 2009 and 2010 

were used for apples since apple juice had a significant impact on exposure. DEEM 

default processing factors were used except for commodities with available chemicalspecific processing studies. Percent crop treated data and PCTn data provided by BEAD 

in 2012 were used. The EDWCs of emamectin benzoate were provided by EFED. A 

drinking water residue distribution based on the PRZM/EXAMS modeling of the use on 

ornamentals was used in the acute assessment. 
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Residue Data used for the Chronic Dietary (Food + Drinking Water) Assessment:

A somewhat refined chronic dietary exposure assessment was conducted. The 

anticipated residue estimates, used for most crops, were single point estimates (averages) 

based on field trial data. The anticipated residues for cucurbits subgroup 9A are shown in 

Table 1 above. The average residue for cantaloupe (0.0035 ppm) was used for the 

cucurbits subgroup 9A (HED Standard Operating Procedures 2000.1, 9/12/2000). 

Anticipated residues for the cucurbits subgroup 9B were based on the LODs for 

cucumber (0.004 ppm) and squash (0.0061 ppm). Tolerance-level residues were used for 

tree nuts (including pistachios) and cottonseed oil. DEEM default processing factors 

were used except for commodities with chemical-specific processing studies. Percent 

crop treated data and PCTn data provided by BEAD in 2012 were used. The EDWC of 

0.150 μg/L (ppb) for the chronic exposure was based on PRZM/EXAMS modeling of the 

use on ornamentals, which resulted in the highest chronic EDWC considering all 

proposed/registered uses. 

III. Percent Crop Treated Information 

A screening level usage analysis (SLUA) dated 5/29/12 was provided by BEAD based on 

data years 2003-2010. A PCTn analysis was also provided by BEAD (DP#403689, J. 

Alsadek, Ph.D., 8/21/12). (Refer to Attachment 2). The estimated maximum percent 

crop treated for each of sixteen crops was used for the acute dietary risk assessment and 

the estimated weighted average percent crop treated was used for the chronic dietary risk 

assessment. 

The following maximum percent crop treated estimates (SLUA, 5/29/12) were used in 

the acute dietary risk assessment for the following crops that are currently registered for 

emamectin benzoate: almonds: 2.5%; apples: 20%; broccoli: 20%; cabbage: 25%; 

cauliflower: 20%; celery: 40%; cotton: 2.5%; lettuce: 20%; pears: 20%; peppers: 15%; 

spinach: 10%; and tomatoes: 20%. 

The following maximum PCTn estimates (DP#403689, J. Alsadek, Ph.D., 8/21/12) were 

used in the dietary risk assessment for the following crops that are the subject of this 

petition for residues of emamectin benzoate: cantaloupe: 51%; cucumber: 26%; squash: 

46%; and watermelon: 21%. 

The following average percent crop treated estimates (SLUA, 5/29/12) were used in the 

acute dietary risk assessment for the following crops that are currently registered for 

emamectin benzoate: almonds: 1%; apples: 10%; broccoli: 5%; cabbage: 10%; 

cauliflower: 10%; celery: 25%; cotton: 1%; lettuce: 10%; pears: 5%; peppers: 5%; 

spinach: 5%; and tomatoes: 10%. 

The following average PCTn estimates (DP#403689, J. Alsadek, Ph.D., 8/21/12) were 

used in the dietary risk assessment for the following crops that are the subject of this 

petition for residues of emamectin benzoate: cantaloupe: 40%; cucumber: 14%; squash: 

29%; and watermelon: 19%. 
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For livestock commodities, percent crop treated for apples was used for beef and dairy 

cattle; percent crop treated for cotton (the only poultry/swine feed item) was used for 

swine. 

IV. Drinking Water Data 

The drinking water residues used in the dietary risk assessment were provided by 

EFED in the following memorandum: “Amended Drinking Water Assessment for the 

proposed use of Emamectin Benzoate on outdoor ornamentals and Group 9 cucurbit 

vegetables” (DP#402307, Tiffany Dowen, 5/30/12) and incorporated directly into this 

dietary assessment. Water residues were incorporated in the DEEM-FCID into the food 

categories “water, direct, all sources” and “water, indirect, all sources.” 

EFED provided EDWCs for the proposed/registered uses of emamectin benzoate 

including the proposed uses on outdoor ornamentals (EPA 100-RURR) and cucurbit 

vegetables (EPA 100-904). EDWCs from use on outdoor-grown ornamentals are the 

highest. Emamectin benzoate residues (parent + degradation products), based on 

applications made to ornamentals and group 9 cucurbits, are not expected to exceed 0.465 

μg/L for the 1 in 10 year daily peak, 0.150 μg/L for the 1 in 10 year annual average, and 

0.112 μg/L for the 30 year annual average (Table 4). A distribution of drinking water 

numbers using the ornamentals scenario was used in the acute assessment. The EDWC 

of 0.150 μg/L was used in the chronic assessment. 

The Agency identified four degradates of concern based on structural similarity to 

emamectin benzoate that are formed via photolysis (MARC memo references: D238206, 

Sept 2, 1997; D255357, Aug 20, 2001; D277085, Aug 20, 2001): 

 (8,9-Z)-4"-epimethylamino-4"-deoxy avermectin B1 (8,9 ZMA isomer); 

 4"-epiamino-4"-deoxyavermectin B1 (AB); 

 avermectin B1 monosaccharide (MAB); and 

 4"-epi-(N-formyl)-4"-deoxyavermectin B1 (FAB). 

These degradates were included in the drinking water assessment for emamectin benzoate 

and are assumed to be of equal or lesser toxicity to that of the parent compound. The 

total toxic residues approach is used for determining the environmental fate data 

parameters for modeling using the Guidance for Selecting Input Parameters in Modeling 

the Environmental Fate and Transport of Pesticides, Version 2.1, October 22, 2009, and 

the draft Guidance for Modeling Pesticides Total Toxic Residues (TTR), dated May 20, 

2009. 
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Table 4. EDWCs for Emamectin Benzoate Residues from Use on Outdoor Ornamentals and Group 

9 Cucurbit Vegetables1

Use Model 

1 in 10 year 30 year Annual 

Peak Annual Mean Average 

μg/L 

Surface Water 

Ornamentals PRZM/EXAMS2 0.465 0.150 0.112 

Ground Water 

Ornamentals/Group 9 

Cucurbit Vegetables SCI-GROW 0.54 x 10-3 0.54 x 10-3 0.54 x 10-3

1 Degradates of concern included in the calculation of EDWCs: (8,9-Z)-4"-epimethylamino-4"-deoxy 

avermectin B1, 4"-epiamino-4"-deoxyavermectin B1, avermectin B1 monosaccharide, and 4"-epi-(Nformyl)-4"-deoxyavermectin B1 (the 8,9 ZMA isomer, AB, MAB, and FAB, respectively). 

2

 Typically, the values generated by the models for drinking water are multiplied by a percent crop area 

factor (PCA). The PCA accounts for the fact that is it unlikely for any basin to be completely planted to 

agricultural crops. The PCA adjustment factor is assumed to be 0.87 for the group 9 cucurbit vegetables 

and 1.0 for the outdoor ornamentals crops as per the PCA guidance. 

The model and its description are available at the EPA internet site: 

http://www.epa.gov/oppefed1/models/water/. 

V. DEEM-FCIDTM Program and Consumption Information

Emamectin benzoate acute and chronic dietary exposure assessments were conducted 

using DEEM-FCID, Version 3.16, which incorporates 2003-2008 consumption data from 

USDA’s NHANES/WWEIA. The data are based on the reported consumption of more 

than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” 

(e.g., apple pie) are linked to EPA-defined food commodities (e.g. apples, peeled fruit - 

cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly 

available recipe translation files developed jointly by USDA/ARS and EPA. For chronic 

exposure assessment, consumption data are averaged for the entire U.S. population and 

within population subgroups. However, for acute exposure assessment, consumption 

data are retained as individual consumption events. Based on analysis of the 2003-2008 

WWEIA consumption data, which took into account dietary patterns and survey 

respondents, HED concluded that it is most appropriate to report risk for the following 

population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, 

children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old. 

For chronic dietary exposure assessment, an estimate of the residue level in each food or 

food-form (e.g., orange or orange juice) on the food commodity residue list is multiplied 

by the average daily consumption estimate for that food/food form to produce a residue 

intake estimate. The resulting residue intake estimate for each food/food form is summed 

with the residue intake estimates for all other food/food forms on the commodity residue 
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list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg 

body weight/day and as a percent of the cPAD. This procedure is performed for each 

population subgroup. 

For acute exposure assessments, individual one-day food consumption data are used on 

an individual-by-individual basis. The reported consumption amounts of each food item 

can be multiplied by a residue point estimate and summed to obtain a total daily pesticide 

exposure for a deterministic exposure assessment, or “matched” in multiple random 

pairings with residue values and then summed in a probabilistic assessment. The 

resulting distribution of exposures is expressed as a percentage of the aPAD on both a 

user (i.e., only those who reported eating relevant commodities/food forms) and a percapita (i.e., those who reported eating the relevant commodities as well as those who did 

not) basis. In accordance with HED policy, per capita exposure and risk are reported for 

analyses performed at all levels of refinement. However, for deterministic assessments, 

any significant differences in user vs. per capita exposure and risk are specifically 

identified and noted in the risk assessment. 

VI. Toxicological Information 

 The HED Risk Assessment Team confirmed endpoints that were previously selected 

(Emamectin Benzoate. Human Health Assessment Scoping Document in Support of 

Registration Review, D385990, N. Dodd, N. Tsaur, and W. Phang, 6/16/11; HIARC’s 

February 26, 1998, July 28 and August 3, 1998, and March 5, 2003 evaluations of the 

emamectin toxicity database). The endpoints and uncertainty factors (UFs) selected by 

HED’s HIARC in 2003 remain unchanged; however, under the current data requirement 

guidelines, immunotoxicity data (OCSPP 870.7800) and a subchronic inhalation study 

(OCSPP 870.3465) are required. 

Although HED concluded that there is a low degree of concern and lack of residual 

uncertainties for pre- and post-natal toxicity, the 10X FQPA safety factor (SF) is retained 

for chronic assessments while a 3X FQPA SF is adequate for acute assessments. 

A 10X FQPA SF has been retained for the chronic assessment to account for the 

steepness of the dose response curve, severity of effects at the LOAEL (death and 

neuropathology), and most importantly the use of a short-term study for long term risk 

assessment. The 10X FQPA SF will also provide adequate protection for the lack of the 

new immunotoxicity study. A 3X FQPA SF has been retained for the acute assessment to 

account for the steepness of the dose-response curve and severity of effects at the 

LOAEL (death and neuropathology). 

The doses and toxicological endpoints selected for use in dietary exposure assessments 

are summarized in Table 5. 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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Page 12 of 30 

Table 5. Summary of Toxicological Doses and Endpoints for Emamectin benzoate for Use in Dietary 

Exposure Assessments 

Exposure/ 

Scenario 

Point of 

Departure 

Uncertainty/ 

FQPA Safety 

Factors 

RfD, PAD, 

Level of 

Concern for 

Risk 

Assessment 

Study and Toxicological Effects 

Acute Dietary 

(All Populations) 

NOAEL= 

0.075 

mg/kg/day 

UFA= 10x 

UFH= 10x 

FQPA SF=3x 

Acute RfD = 

0.00025 

mg/kg/day 

aPAD 

=0.00025mg/kg

/day 

15-day mouse 

LOAEL = 0.1 mg/kg/day based on 

tremors on day 3 of dosing. 

Chronic Dietary 

(All Populations) 

NOAEL= 

0.075 

mg/kg/day 

UFA=10x 

UFH=10x 

FQPA SF=10x 

Chronic RfD = 

0.000075 

mg/kg/day 

cPAD = 

0.000075 

mg/kg/day 

15-day mouse 

LOAEL = 0.1mg/kg/day based on 

moribund sacrifices, clinical signs of 

neurotoxicity, decreases in body 

weight and food consumption and 

histopathological lesions in the 

sciatic nerve. 

Cancer (oral, 

dermal, 

inhalation) 

Classification: “Not likely to be Carcinogenic to Humans” based on the absence of 

significant tumor increases in two adequate rodent carcinogenicity studies. 

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response 

data and used to mark the beginning of extrapolation to determine risk associated with lower 

environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest 

observed adverse effect level. UF = uncertainty factor. UFA = extrapolation from animal to human 

(interspecies). UFH = potential variation in sensitivity among members of the human population 

(intraspecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). 

RfD = reference dose. 

VII. Results/Discussion 

As stated above, for acute and chronic assessments, HED is concerned when dietary risk 

exceeds 100% of the PAD. The DEEM-FCID analyses estimate the dietary exposure of 

the U.S. population and various population subgroups. The results reported in Tables 6 

and 7 are for the general U.S. Population, all infants (<1 year old), children 1-2, children 

3-5, children 6-12, youth 13-19, females 13-49, adults 20-49, and adults 50-99 years. 

 

Results of Acute Dietary (Food and Drinking Water) Exposure Analysis

The results of the acute dietary (food + drinking water) exposure analysis at the 95th, 99th, 

and 99.9th percentiles of exposure are reported in Table 6. The emamectin benzoate acute 

dietary risk estimates for food and drinking water using the ornamental scenario for 

drinking water are below HED’s level of concern (<100% aPAD) at the 99.9th percentile 

of exposure for the general U.S. population and all population subgroups, at 36% of the 

aPAD for the general U.S. population and 60% of the aPAD for children 1-2 years old, 

the most highly exposed subgroup. 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

______________________________________________________________________________________

Page 13 of 30 

Table 6. Results of Acute Dietary (Food and Drinking Water) Exposure Analysis Using DEEM FCID1

Population Subgroup aPAD 

(mg/kg/day)

95th Percentile 99th Percentile 99.9th Percentile

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

Exposure 

(mg/kg/day)

% 

aPAD

General U.S. Population 0.00025 0.000019 7.4 0.000038 15 0.000091 36 

All Infants (< 1 year old) 0.000037 15 0.000070 28 0.000138 55 

Children 1-2 years old 0.000038 15 0.000074 29 0.000151 60 

Children 3-5 years old 0.000028 11 0.000059 23 0.000135 54 

Children 6-12 years old 0.000018 7.3 0.000042 17 0.000082 33 

Youth 13-19 years old 0.000012 4.8 0.000025 10 0.000084 33 

Adults 20-49 years old 0.000016 6.5 0.000032 13 0.000077 31 

Adults 50-99 years old 0.000018 7.3 0.000035 14 0.000093 37 

Females 13-49 years old 0.000016 6.5 0.000033 13 0.000076 30 

1

The population with the highest exposure is bolded. 

Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis

The results of the chronic dietary (food and drinking water) exposure analysis are 

reported in the summary table below. For the chronic dietary assessment, all population 

subgroups have risk estimates which are below HED’s level of concern. The emamectin 

benzoate chronic dietary risk estimates for food and drinking water using the ornamental 

scenario for drinking water are below HED’s level of concern for the general U.S. 

population and all population subgroups, at 7.5% of the cPAD for the general U.S. 

population and 16% of the cPAD for all infants (<1 year old), the most highly exposed 

subgroup. 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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Page 14 of 30 

Table 7. Summary of Dietary (Food and Drinking Water) Exposure and Risk for Emamectin 

Benzoate

Population Subgroup 

Acute Dietary 

(99.9 Percentile) Chronic Dietary 

Dietary Exposure 

(mg/kg/day) % aPAD* 

Dietary 

Exposure 

(mg/kg/day) 

% cPAD* 

General U.S. Population 0.000091 36 0.000006 7.5 

All Infants (<1 year old)* 0.000138 55 0.000012 16 

Children 1-2 years old* 0.000151 60 0.000011 15 

Children 3-5 years old 0.000135 54 0.000009 12 

Children 6-12 years old 0.000082 33 0.000006 7.4 

Youth 13-19 years old 0.000084 33 0.000004 5.2 

Adults 20-49 years old 0.000077 31 0.000005 6.9 

Adults 50-99 years old 0.000093 37 0.000006 7.7 

Females 13-49 years old 0.000076 30 0.000005 6.8 

*The subpopulations with the highest risk estimates are bolded. 

VIII. Characterization of Inputs/Outputs 

The acute and chronic assessments for food incorporate somewhat refined anticipated 

residue estimates for most commodities that were derived from field trial data and 

%CT/PCTn data. Monitoring data were used for apples in the acute assessment since 

apple juice had a significant impact on exposure. The use of more monitoring data and 

food preparation-reduction factors for washing, cooking, etc. may have resulted in more 

refined estimates of dietary exposure. More highly refined analyses are not needed at this 

time since the risk estimates are below HED’s level of concern. 

 IX. Conclusions 

The acute dietary exposure assessment is a probabilistic assessment conducted for all 

proposed/registered food uses of emamectin benzoate and drinking water. The 

anticipated residue estimates used for most crops were based on field trial data, 

incorporated percent crop treated or PCTn estimates provided by BEAD, and processing 

factors where appropriate. PDP monitoring data were used for apples. A drinking water 

residue distribution based on the use on ornamentals was used in the acute assessment. 

The acute dietary exposure estimates for food and drinking water are below HED’s level 

of concern at the 99.9th percentile of exposure for all population subgroups (36% of the 

aPAD for the general U.S. population and 60% of the aPAD for children 1-2 years old). 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

______________________________________________________________________________________

Page 15 of 30 

The chronic dietary exposure assessment is a somewhat refined assessment conducted for 

all proposed/registered food uses of emamectin benzoate and drinking water. The 

anticipated residue estimates used for most crops were single point estimates (averages) 

based on field trial data, incorporated percent crop treated or PCTn estimates provided by 

BEAD, and processing factors where appropriate. An EDWC based on the use on 

ornamentals was used in the chronic assessment. The chronic dietary exposure estimates 

for food and drinking water are below HED’s level of concern for all population 

subgroups (7.5% of the cPAD for the general U.S. population and 16% of the cPAD for 

all infants less than 1 year old). 

X. List of Attachments 

Attachment 1: Acute Residue Distribution Files and Chronic Point Estimates. 

Attachment 2: Percent Crop Treated Memos from BEAD. 

Attachment 3: Acute Food plus Water Residue Input File. 

Attachment 4: Acute Results File. 

Attachment 5: Chronic Food plus Water Residue Input File. 

Attachment 6: Chronic Results File. 

cc: N. Dodd 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

______________________________________________________________________________________

Page 16 of 30 

Attachment 1: Acute Residue Distribution Files and Chronic Point Estimates 

RDF 1 

'Apple, PDP Data, 20%CT 

TOTALZ=1022 

TOTALLOD=256 

LODRES=0.0005 

RDF 2 

'Bell Pepper 

Field trial data 15%CT 

TOTALZ=17 

TOTALNZ=3 

0.010 

0.010 

0.010 

RDF 3 

'Broccoli 

Field trial data 20%CT 

TOTALZ=48 

TOTALNZ=12 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.004 

0.004 

0.0064 

0.0045 

RDF 4 

'Cabbage 

Field trial data 25%CT 

TOTALZ=54 

TOTALNZ=18 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.004 

0.004 

Chronic Apple Field Trial 

data; n = 30 

Chronic= 0.010 x 0.05 

= 0.0005 

Chronic= 0.003 x 0.05= 

0.00015 

Chronic= 0.002 x 0.10= 

0.0002 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.009055 

0.007055 

Chronic= 0.0020 x 0.10= 

0.00020 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

______________________________________________________________________________________

Page 17 of 30 

RDF 5 

‘Cauliflower 

Field trial data 20%CT 

TOTALZ=48 

TOTALNZ=12 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.004 

RDF 6 

'Celery 

Field trial data 40%CT 

TOTALZ=32 

TOTALNZ=21 

0.008 

0.008 

0.006 

0.006 

0.006 

0.006 

0.004 

0.004 

0.002 

0.0082 

0.0069 

0.0121 

0.0104 

0.0055 

0.0062 

0.0066 

0.0048 

0.0054 

0.0083 

0.0075 

0.0044 

RDF 7 

'Lettuce-head 

Field trial data 20%CT 

TOTALZ=68 

TOTALNZ=17 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.002 

0.006 

0.006 

0.006 

0.0065 

0.004 

0.0067 

0.0063 

RDF 8 

'Lettuce-leaf 

Field trial data 20%CT 

TOTALZ=80 

TOTALNZ=20 

0.01 

0.01 

0.01 

0.01 

0.01 

0.01 

0.01 

0.012 

0.012 

0.014 

0.014 

0.0114 

0.028 

0.025 

0.033 

0.047 

0.011 

0.016 

0.017 

0.039 

Chronic= 0.002 x 0.10= 

0.0002 

Chronic= 0.0065 x 

0.25= 0.0016 

Chronic= 0.0036 x 

0.10= 0.0004 

Chronic= 0.017 x 0.10= 

0.002 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

______________________________________________________________________________________

Page 18 of 30 

RDF 9 

'Mustard greens 

Field trial data 100%CT 

TOTALZ=0 

0.01 

0.01 

0.01 

0.01 

0.01 

0.01 

0.01 

0.01 

0.01 

0.01 

0.01 

0.01 

0.01 

0.013 

0.013 

0.013 

0.013 

0.014 

0.016 

0.1212 

RDF 10 

'Non-bell peppers 

Field trial data 15%CT 

TOTALZ=68 

TOTALNZ=12 

0.010 

0.010 

0.010 

0.010 

0.010 

0.010 

0.010 

0.010 

0.010 

0.010 

0.010 

0.010 

RDF 11 

'Pear 

Field trial data 20%CT 

TOTALZ=64 

TOTALNZ=16 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.008055 

0.007055 

0.007055 

0.007055 

RDF 12 

'Spinach 

Field trial data 10%CT 

TOTALZ=54 

TOTALNZ=6 

0.010 

0.010 

0.011 

0.011 

0.011 

0.012 

Chronic= 0.017 x 1= 0.02 Chronic= 0.010 x 

0.05= 0.0005 

Chronic= 0.0030 x 

0.05= 0.00015 

Chronic= 0.011 x 0.05= 

0.00055 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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Page 19 of 30 

RDF 13 

‘Tomato Field trial data 

20%CT 

TOTALZ=124 

TOTALNZ=31 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.001556 

0.003556 

0.003556 

0.003556 

0.003556 

0.003556 

0.003556 

0.005 

0.005 

RDF 14 

‘Milk [apple 20%CT] 

TOTALZ=80 

20,0.0003 

RDF 15 

'Cattle fat [apple 

20%CT] 

TOTALZ=80 

20,0.003 

RDF 16 

'Cattle liver [apple 

20%CT] 

TOTALZ=80 

20,0.01 

Chronic= 0.0022 x 0.10= 

0.0002 

Chronic= 0.0003 x 

0.10 = 0.00003 

Chronic= 0.003 x 0.10= 

0.0003 

Chronic= 0.01 x 0.10= 

0.001 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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Page 20 of 30 

RDF 17 

'Cattle meat [apple 

20%CT] 

TOTALZ=80 

20,0.002 

RDF 18 

'Cattle meat byproduct 

[apple 20%CT] 

TOTALZ=80 

20,0.01 

RDF 19 

'Hog fat [cotton 

2.5%CT] 

TOTALZ=97 

3,0.003 

RDF 20 

'Hog liver [cotton 

2.5%CT] 

TOTALZ=97 

3,0.01 

Chronic= 0.002 x 0.10= 

0.0002 

Chronic= 0.01 x 0.10= 

0.001 

Chronic = 0.003 x 0.01 

= 0.00003 

Chronic = 0.01 x 0.01 = 

0.0001 

RDF 21 

'Hog meat [cotton 

2.5%CT] 

TOTALZ=97 

3,0.002 

RDF 22 

‘Hog meat bypd [cotton 

2.5%CT] 

TOTALZ=97 

3,0.01 

RDF 23 

'Cream [apple 20%CT] 

TOTALZ=80 

20,0.002 

RDF 24 

‘Cantaloupe 

Field trial data 51%CT 

TOTALZ=10 

TOTALNZ=10 

0.0030 

0.0030 

0.0030 

0.0030 

0.0036 

0.0040 

0.0037 

0.0032 

0.0051 

0.0037 

Chronic = 0.002 x 0.01 

= 0.00002 

Chronic = 0.01 x 0.01 = 

0.0001 

Chronic = 0.002 x 0.10 

= 0.0002 

Chronic = 0.0035 x 0.40 

= 0.0014 

RDF 25 

‘Cucumber 

Field trial data 26%CT 

TOTALZ=23 

TOTALNZ=8 

0.004 

0.004 

0.004 

0.004 

0.004 

0.004 

0.004 

0.004 

RDF 26 

‘Summer Squash 

Field trial data 46%CT 

TOTALZ=9 

TOTALNZ=8 

0.0061 

0.0061 

0.0061 

0.0061 

0.0061 

0.0061 

0.0061 

0.0061 

 

RDF 27 

‘Winter Squash Field 

Trial data 46%CT 

TOTALZ=9 

TOTALNZ=8 

0.0061 

0.0061 

0.0061 

0.0061 

0.0061 

0.0061 

0.0061 

0.0061 

RDF 28 

‘Watermelon 

Cantaloupe field trial 

data 21%CT 

TOTALZ=38 

TOTALNZ=10 

0.0030 

0.0030 

0.0030 

0.0030 

0.0036 

0.0040 

0.0037 

0.0032 

0.0051 

0.0037

Chronic = 0.004 x 0.14 

= 0.00056 

Chronic = 0.0061 x 

0.29 = 0.0018 

Chronic = 0.0061 x 

0.29 = 0.0018 

Chronic = 0.0035 x 0.19 

= 0.00066 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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Page 21 of 30 

RDF 29 

Almond 

2.5%CT 

TOTALZ=97 

3,0.02 

RDF 30 

'Cattle kidney [apple 

20%CT] 

TOTALZ=80 

20, 0.0045 

RDF 31 

'Subgroup 9A Other 

Cantaloupe Field Trial 

data 100%CT 

TOTALZ=0 

0.0030 

0.0030 

0.0030 

0.0030 

0.0036 

0.0040 

0.0037 

0.0032 

0.0051 

0.0037 

RDF 32 

Ormamentals Drinking 

Water 

Chronic = 0.02 x 0.01 = 

0.0002 

Chronic = 0.0045 x 

0.10 = 0.00045 

Chronic = 0.0035 x 1 = 

0.0035 

Chronic = 0.000150 

RDF 33 

Hog kidney [cotton 

2.5%CT] 

TOTALZ=97 

3, 0.0045 

Chronic = 0.0045 x 

0.01 = 0.000045 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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Page 22 of 30 

Attachment 2: Percent Crop Treated Memos from BEAD 

A screening level usage analysis (SLUA) dated 5/29/12 was provided by BEAD based on 

data years 2003-2010. The following data were excerpted from the 5/29/12 SLUA. 

Screening Level Estimates of Agricultural Uses of Emamectin Benzoate (5/29/12) 

Crop Percent Crop Treated 

Average Maximum 

Almonds <1 <2.5 

Apples 10 20 

Broccoli 5 20 

Cabbage 10 25 

Cauliflower 10 20 

Celery 25 40 

Cotton <1 <2.5 

Lettuce 10 20 

Pears 5 20 

Peppers 5 15 

Spinach 5 10 

Tomatoes 10 20 

The following PCTn data were provided by BEAD (DP#403689, J. Alsadek, Ph.D., 

8/21/12): 

PCTn Data for Agricultural Uses of Emamectin Benzoate (8/21/12) 

Crop PCTn 

Average Maximum 

Cantaloupe 40 51 

Cucumber 14 26 

Squash 29 46 

Watermelon 19 21 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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Page 23 of 30 

Attachment 3: Acute Food plus Water Residue Input File 

Filename: C:\Documents and Settings\NDODD\My Documents\DEEM Version 3.16\emamectin 

benzoate 2013\EMAMECTINACUTECUCURBITS121212.R08 

Chemical: Emamectin Benzoate 

RfD(Chronic): 0 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day 

RfD(Acute): .00025 mg/kg bw/day NOEL(Acute): .075 mg/kg bw/day 

Date created/last modified: 12-19-2012/12:51:40 Program ver. 3.16, 03-08-d 

Comment: General Population; include pome fruits + drinking water 

----------------------------------------------------------------------------------- 

RDL indices and parameters for Monte Carlo Analysis: 

Index Dist Parameter #1 Param #2 Param #3 Comment 

 # Code 

----- ---- ------------ -------- -------- ------- 

 1 6 apple.rdf 

 2 6 bellpepper.rdf 

 3 6 broccoli.rdf 

 4 6 cabbage.rdf 

 5 6 cauliflower.rdf 

 6 6 celery.rdf 

 7 6 lettucehead.rdf 

 8 6 lettuceleaf.rdf 

 9 6 mustardgreen.rdf 

 10 6 nonbellpepper.rdf 

 11 6 pear.rdf 

 12 6 spinach.rdf 

 13 6 tomato.rdf 

 14 6 milk.rdf 

 15 6 cattlefat.rdf 

 16 6 cattleliver.rdf 

 17 6 cattlemeat.rdf 

 18 6 cattlembypd.rdf 

 19 6 hogfat.rdf 

 20 6 hogliver.rdf 

 21 6 hogmeat.rdf 

 22 6 hogmeatbypd.rdf 

 23 6 cream.RDF 

 24 6 cantaloupe.rdf 

 25 6 cucumber.rdf 

 26 6 Summer squash.rdf 

 27 6 Winter squash.rdf 

 28 6 watermelon.rdf 

 29 6 almond.rdf 

 30 6 cattlekidney.rdf 

 31 6 Subgroup 9A Other.rdf 

 32 6 ornamentals DW.rdf 

 33 6 hog kidney.rdf 

 EPA Crop Commodity Name Def Res Adj.Factors RDLComment 

 Code Grp (ppm) #1 #2 Pntr 

---------- ---- ------------------------------- ---------- ------ ------ --- ------- 

0401005000 4A Amaranth, leafy 0.012000 1.000 1.000 

0401018000 4A Arugula 0.012000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 0.012000 1.000 1.000 

0401133000 4A Cress, garden 0.012000 1.000 1.000 

0401134000 4A Cress, upland 0.012000 1.000 1.000 

0401138000 4A Dandelion, leaves 0.012000 1.000 1.000 

0401150000 4A Endive 0.012000 1.000 1.000 

0401204000 4A Lettuce, head 0.006700 1.000 1.000 7 

0401205000 4A Lettuce, leaf 0.047000 1.000 1.000 8 

0401248000 4A Parsley, leaves 0.012000 1.000 1.000 

0401313000 4A Radicchio 0.006700 1.000 1.000 

0401355000 4A Spinach 0.012000 1.000 1.000 12 

0401355001 4A Spinach-babyfood 0.012000 1.000 1.000 12 

0402076000 4B Cardoon 0.012100 1.000 1.000 

0402085000 4B Celery 0.012100 1.000 1.000 6 

0402085001 4B Celery-babyfood 0.012100 1.000 1.000 6 

0402086000 4B Celery, juice 0.012100 1.000 1.000 6 

0402087000 4B Celtuce 0.012100 1.000 1.000 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

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Page 24 of 30 

0402152000 4B Fennel, Florence 0.012100 1.000 1.000 

0402322000 4B Rhubarb 0.012100 1.000 1.000 

0402367000 4B Swiss chard 0.012100 1.000 1.000 

0501061000 5A Broccoli 0.006400 1.000 1.000 3 

0501061001 5A Broccoli-babyfood 0.006400 1.000 1.000 3 

0501062000 5A Broccoli, Chinese 0.006400 1.000 1.000 

0501064000 5A Brussels sprouts 0.004000 1.000 1.000 

0501069000 5A Cabbage 0.004000 1.000 1.000 4 

0501071000 5A Cabbage, Chinese, napa 0.004000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 0.006400 1.000 1.000 

0501083000 5A Cauliflower 0.004000 1.000 1.000 5 

0501196000 5A Kohlrabi 0.004000 1.000 1.000 

0502063000 5B Broccoli raab 0.121200 1.000 1.000 9 

0502070000 5B Cabbage, Chinese, bok choy 0.121200 1.000 1.000 9 

0502117000 5B Collards 0.121200 1.000 1.000 9 

0502194000 5B Kale 0.121200 1.000 1.000 9 

0502229000 5B Mustard greens 0.121200 1.000 1.000 9 

0502318000 5B Rape greens 0.121200 1.000 1.000 9 

0502389000 5B Turnip, greens 0.121200 1.000 1.000 9 

0801374000 8A Tomatillo 0.005000 1.000 1.000 

0801375000 8A Tomato 0.005000 1.000 1.000 13 

0801375001 8A Tomato-babyfood 0.005000 1.000 1.000 13 

0801376000 8A Tomato, paste 0.002200 1.000 0.200 B; no 

 Full comment: B; no concentration (D328149) 

0801376001 8A Tomato, paste-babyfood 0.002200 1.000 0.200 B 

0801377000 8A Tomato, puree 0.002200 1.000 0.200 B; no 

 Full comment: B; no concentration (D328149) 

0801377001 8A Tomato, puree-babyfood 0.002200 1.000 0.200 B 

0801378000 8A Tomato, dried 0.002200 14.300 0.200 B 

0801378001 8A Tomato, dried-babyfood 0.002200 14.300 0.200 B 

0801379000 8A Tomato, juice 0.005000 1.500 1.000 13 

0801380000 8A Tomato, Tree 0.005000 1.000 1.000 

0802148000 8BC Eggplant 0.010000 1.000 1.000 

0802234000 8BC Okra 0.010000 1.000 1.000 

0802270000 8B Pepper, bell 0.010000 1.000 1.000 2 

0802270001 8B Pepper, bell-babyfood 0.010000 1.000 1.000 2 

0802271000 8B Pepper, bell, dried 0.010000 1.000 0.150 Blende 

 Full comment: Blended (B) 

0802271001 8B Pepper, bell, dried-babyfood 0.010000 1.000 0.150 B 

0802272000 8BC Pepper, nonbell 0.010000 1.000 1.000 10 

0802272001 8BC Pepper, nonbell-babyfood 0.010000 1.000 1.000 10 

0802273000 8BC Pepper, nonbell, dried 0.010000 1.000 0.150 B 

0901075000 9A Cantaloupe 0.005100 1.000 1.000 24 LOQ = 

 Full comment: LOQ = 0.001 x 6; used 1/2 LOQ for ND 

0901187000 9A Honeydew melon 0.005100 1.000 1.000 31 

0901399000 9A Watermelon 0.005100 1.000 1.000 28 

0901400000 9A Watermelon, juice 0.005100 1.000 1.000 28 

0902021000 9B Balsam pear 0.004000 1.000 1.000 

0902088000 9B Chayote, fruit 0.006100 1.000 1.000 

0902102000 9B Chinese waxgourd 0.004000 1.000 1.000 

0902135000 9B Cucumber 0.004000 1.000 1.000 25 LOD = 

 Full comment: LOD = 0.004 

0902308000 9B Pumpkin 0.006100 1.000 1.000 

0902309000 9B Pumpkin, seed 0.006100 1.000 1.000 B 

0902356000 9B Squash, summer 0.006100 1.000 1.000 26 LOD = 

 Full comment: LOD = 0.0061 

0902356001 9B Squash, summer-babyfood 0.006100 1.000 1.000 26 

0902357000 9B Squash, winter 0.006100 1.000 1.000 27 

0902357001 9B Squash, winter-babyfood 0.006100 1.000 1.000 27 

1100007000 11 Apple, fruit with peel 0.009055 1.000 1.000 1 

1100008000 11 Apple, peeled fruit 0.009055 1.000 1.000 1 

1100008001 11 Apple, peeled fruit-babyfood 0.009055 1.000 1.000 1 

1100009000 11 Apple, dried 0.002000 8.000 0.200 B 

1100009001 11 Apple, dried-babyfood 0.002000 8.000 0.200 B 

1100010000 11 Apple, juice 0.009055 1.000 1.000 1 

1100010001 11 Apple, juice-babyfood 0.009055 1.000 1.000 1 

1100011000 11 Apple, sauce 0.009055 1.000 1.000 1 

1100011001 11 Apple, sauce-babyfood 0.009055 1.000 1.000 1 

1100129000 11 Crabapple 0.009055 1.000 1.000 

1100173500 11 Goji berry 0.005000 1.000 1.000 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

______________________________________________________________________________________

Page 25 of 30 

1100210000 11 Loquat 0.008055 1.000 1.000 

1100266000 11 Pear 0.008055 1.000 1.000 11 

1100266001 11 Pear-babyfood 0.008055 1.000 1.000 11 

1100267000 11 Pear, dried 0.003000 6.250 0.200 B 

1100268000 11 Pear, juice 0.008055 1.000 1.000 11 

1100268001 11 Pear, juice-babyfood 0.008055 1.000 1.000 11 

1100310000 11 Quince 0.008055 1.000 1.000 

1400003000 14 Almond 0.020000 1.000 1.000 29 

1400003001 14 Almond-babyfood 0.020000 1.000 1.000 29 

1400004000 14 Almond, oil 0.020000 1.000 0.025 B 

1400004001 14 Almond, oil-babyfood 0.020000 1.000 0.025 B 

1400059000 14 Brazil nut 0.020000 1.000 1.000 

1400068000 14 Butternut 0.020000 1.000 1.000 

1400081000 14 Cashew 0.020000 1.000 1.000 

1400092000 14 Chestnut 0.020000 1.000 1.000 

1400155000 14 Hazelnut 0.020000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.020000 1.000 1.000 B 

1400185000 14 Hickory nut 0.020000 1.000 1.000 

1400213000 14 Macadamia nut 0.020000 1.000 1.000 

1400269000 14 Pecan 0.020000 1.000 1.000 

1400278000 14 Pine nut 0.020000 1.000 1.000 

1400282000 14 Pistachio 0.020000 1.000 1.000 

1400391000 14 Walnut 0.020000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.025000 1.000 0.025 B 

2003128001 20C Cottonseed, oil-babyfood 0.025000 1.000 0.025 B 

3100044000 31 Beef, meat 0.002000 1.000 1.000 17 

3100044001 31 Beef, meat-babyfood 0.002000 1.000 1.000 17 

3100045000 31 Beef, meat, dried 0.002000 1.920 1.000 17 

3100046000 31 Beef, meat byproducts 0.010000 1.000 1.000 18 

3100046001 31 Beef, meat byproducts-babyfood 0.010000 1.000 1.000 18 

3100047000 31 Beef, fat 0.003000 1.000 1.000 15 

3100047001 31 Beef, fat-babyfood 0.003000 1.000 1.000 15 

3100048000 31 Beef, kidney 0.004500 1.000 1.000 30 

3100049000 31 Beef, liver 0.010000 1.000 1.000 16 

3100049001 31 Beef, liver-babyfood 0.010000 1.000 1.000 16 

3200169000 32 Goat, meat 0.002000 1.000 1.000 17 

3200170000 32 Goat, meat byproducts 0.010000 1.000 1.000 18 

3200171000 32 Goat, fat 0.003000 1.000 1.000 15 

3200172000 32 Goat, kidney 0.004500 1.000 1.000 30 

3200173000 32 Goat, liver 0.010000 1.000 1.000 16 

3300189000 33 Horse, meat 0.002000 1.000 1.000 17 

3400290000 34 Pork, meat 0.002000 1.000 1.000 21 

3400290001 34 Pork, meat-babyfood 0.002000 1.000 1.000 21 

3400291000 34 Pork, skin 0.010000 1.000 1.000 22 

3400292000 34 Pork, meat byproducts 0.010000 1.000 1.000 22 

3400292001 34 Pork, meat byproducts-babyfood 0.010000 1.000 1.000 22 

3400293000 34 Pork, fat 0.003000 1.000 1.000 19 

3400293001 34 Pork, fat-babyfood 0.003000 1.000 1.000 19 

3400294000 34 Pork, kidney 0.004500 1.000 1.000 33 

3400295000 34 Pork, liver 0.010000 1.000 1.000 20 

3500339000 35 Sheep, meat 0.002000 1.000 1.000 17 

3500339001 35 Sheep, meat-babyfood 0.002000 1.000 1.000 17 

3500340000 35 Sheep, meat byproducts 0.010000 1.000 1.000 18 

3500341000 35 Sheep, fat 0.003000 1.000 1.000 15 

3500341001 35 Sheep, fat-babyfood 0.003000 1.000 1.000 15 

3500342000 35 Sheep, kidney 0.004500 1.000 1.000 30 

3500343000 35 Sheep, liver 0.010000 1.000 1.000 16 

3600222000 36 Milk, fat 0.002000 1.000 1.000 23 

3600222001 36 Milk, fat-baby food/infant formu 0.002000 1.000 1.000 23 

3600223000 36 Milk, nonfat solids 0.000300 1.000 1.000 14 

3600223001 36 Milk, nonfat solids-baby food/in 0.000300 1.000 1.000 14 

3600224000 36 Milk, water 0.000300 1.000 1.000 14 

3600224001 36 Milk, water-babyfood/infant form 0.000300 1.000 1.000 14 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.000300 1.000 1.000 14 

8601000000 86A Water, direct, all sources 0.000465 1.000 1.000 32 

8602000000 86B Water, indirect, all sources 0.000465 1.000 1.000 32 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

______________________________________________________________________________________

Page 26 of 30 

Attachment 4: Acute Results File 

U.S. EPA Ver. 3.16, 03-08-d 

DEEM-FCID ACUTE Analysis for EMAMECTIN BENZOATE NHANES 2003-2008 2-Day 

Residue file: EMAMECTINACUTECUCURBITS121212.R08 Adjustment factor #2 used. 

Analysis Date: 12-19-2012/13:04:38 Residue file dated: 12-19-2012/12:51:40 

NOEL (Acute) = 0.075000 mg/kg body-wt/day 

RAC/FF intake summed over 24 hours 

MC iterations = 1000; MC list in residue file; MC seed = 4; RNG = MS VB 

Run Comment: "General Population; include pome fruits + drinking water" 

=============================================================================== 

Summary calculations--per capita: 

--- 95th Percentile---- --- 99th Percentile---- ---99.9th Percentile---- 

 Exposure % aRfD MOE Exposure % aRfD MOE Exposure % aRfD MOE 

---------- ------- -------- ---------- ------- -------- ---------- ------- -------- 

Total US Population: 

 0.000019 7.44 4030 0.000038 15.14 1981 0.000091 36.35 825 

All Infants: 

 0.000037 14.79 2027 0.000070 28.16 1065 0.000138 55.17 543 

Children 1-2: 

 0.000038 15.25 1967 0.000074 29.47 1018 0.000151 60.35 497 

Children 3-5: 

 0.000028 11.29 2657 0.000059 23.44 1279 0.000135 53.93 556 

Children 6-12: 

 0.000018 7.32 4099 0.000042 16.70 1796 0.000082 32.98 909 

Youth 13-19: 

 0.000012 4.85 6190 0.000025 10.09 2973 0.000084 33.47 896 

Adults 20-49: 

 0.000016 6.52 4599 0.000032 12.96 2315 0.000077 30.78 974 

Adults 50-99: 

 0.000018 7.31 4104 0.000035 14.10 2127 0.000093 37.32 803 

Female 13-49: 

 0.000016 6.48 4627 0.000033 13.19 2274 0.000076 30.48 984 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

______________________________________________________________________________________

Page 27 of 30 

Attachment 5: Chronic Food plus Water Residue Input File 

Filename: C:\Documents and Settings\NDODD\My Documents\DEEM Version 3.16\emamectin 

benzoate 2013\EMAMECTINCHRONICCUCURBITS 121212.R08 

Chemical: Emamectin Benzoate 

RfD(Chronic): .000075 mg/kg bw/day NOEL(Chronic): .075 mg/kg bw/day 

RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day 

Date created/last modified: 12-19-2012/12:52:17 Program ver. 3.16, 03-08-d 

Comment: General Population; include pome fruits + drinking water 

----------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Commodity Name (ppm) #1 #2 

---------- ---- ------------------------------- ---------- ------ ------ ------- 

0401005000 4A Amaranth, leafy 0.011000 1.000 1.000 

0401018000 4A Arugula 0.011000 1.000 1.000 

0401104000 4A Chrysanthemum, garland 0.011000 1.000 1.000 

0401133000 4A Cress, garden 0.011000 1.000 1.000 

0401134000 4A Cress, upland 0.011000 1.000 1.000 

0401138000 4A Dandelion, leaves 0.011000 1.000 1.000 

0401150000 4A Endive 0.011000 1.000 1.000 

0401204000 4A Lettuce, head 0.003600 1.000 0.100 

0401205000 4A Lettuce, leaf 0.017000 1.000 0.100 

0401248000 4A Parsley, leaves 0.011000 1.000 1.000 

0401313000 4A Radicchio 0.003600 1.000 1.000 

0401355000 4A Spinach 0.011000 1.000 0.050 

0401355001 4A Spinach-babyfood 0.011000 1.000 0.050 

0402076000 4B Cardoon 0.006500 1.000 1.000 

0402085000 4B Celery 0.006500 1.000 0.250 

0402085001 4B Celery-babyfood 0.006500 1.000 0.250 

0402086000 4B Celery, juice 0.006500 1.000 0.250 

0402087000 4B Celtuce 0.006500 1.000 1.000 

0402152000 4B Fennel, Florence 0.006500 1.000 1.000 

0402322000 4B Rhubarb 0.006500 1.000 1.000 

0402367000 4B Swiss chard 0.006500 1.000 1.000 

0501061000 5A Broccoli 0.003000 1.000 0.050 

0501061001 5A Broccoli-babyfood 0.003000 1.000 0.050 

0501062000 5A Broccoli, Chinese 0.003000 1.000 1.000 

0501064000 5A Brussels sprouts 0.002000 1.000 1.000 

0501069000 5A Cabbage 0.002000 1.000 0.100 

0501071000 5A Cabbage, Chinese, napa 0.002000 1.000 1.000 

0501072000 5A Cabbage, Chinese, mustard 0.003000 1.000 1.000 

0501083000 5A Cauliflower 0.002000 1.000 0.100 

0501196000 5A Kohlrabi 0.002000 1.000 1.000 

0502063000 5B Broccoli raab 0.017000 1.000 1.000 

0502070000 5B Cabbage, Chinese, bok choy 0.017000 1.000 1.000 

0502117000 5B Collards 0.017000 1.000 1.000 

0502194000 5B Kale 0.017000 1.000 1.000 

0502229000 5B Mustard greens 0.017000 1.000 1.000 

0502318000 5B Rape greens 0.017000 1.000 1.000 

0502389000 5B Turnip, greens 0.017000 1.000 1.000 

0801374000 8A Tomatillo 0.002200 1.000 1.000 

0801375000 8A Tomato 0.002200 1.000 0.100 

0801375001 8A Tomato-babyfood 0.002200 1.000 0.100 

0801376000 8A Tomato, paste 0.002200 1.000 0.100 

0801376001 8A Tomato, paste-babyfood 0.002200 1.000 0.100 

0801377000 8A Tomato, puree 0.002200 1.000 0.100 

0801377001 8A Tomato, puree-babyfood 0.002200 1.000 0.100 

0801378000 8A Tomato, dried 0.002200 14.300 0.100 

0801378001 8A Tomato, dried-babyfood 0.002200 14.300 0.100 

0801379000 8A Tomato, juice 0.002200 1.500 0.100 

0801380000 8A Tomato, Tree 0.002200 1.000 1.000 

0802148000 8BC Eggplant 0.010000 1.000 1.000 

0802234000 8BC Okra 0.010000 1.000 1.000 

0802270000 8B Pepper, bell 0.010000 1.000 0.050 

0802270001 8B Pepper, bell-babyfood 0.010000 1.000 0.050 

0802271000 8B Pepper, bell, dried 0.010000 1.000 0.050 

0802271001 8B Pepper, bell, dried-babyfood 0.010000 1.000 0.050 

0802272000 8BC Pepper, nonbell 0.010000 1.000 0.050 

0802272001 8BC Pepper, nonbell-babyfood 0.010000 1.000 0.050 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

______________________________________________________________________________________

Page 28 of 30 

0802273000 8BC Pepper, nonbell, dried 0.010000 1.000 0.050 

0901075000 9A Cantaloupe 0.003500 1.000 0.400 

0901187000 9A Honeydew melon 0.003500 1.000 1.000 

0901399000 9A Watermelon 0.003500 1.000 0.190 

0901400000 9A Watermelon, juice 0.003500 1.000 0.190 

0902021000 9B Balsam pear 0.004000 1.000 1.000 

0902088000 9B Chayote, fruit 0.006100 1.000 1.000 

0902102000 9B Chinese waxgourd 0.004000 1.000 1.000 

0902135000 9B Cucumber 0.004000 1.000 0.140 LOQ = 

 Full comment: LOQ = 0.02 

0902308000 9B Pumpkin 0.006100 1.000 1.000 

0902309000 9B Pumpkin, seed 0.006100 1.000 1.000 

0902356000 9B Squash, summer 0.006100 1.000 0.290 LOQ = 

 Full comment: LOQ = 0.02 

0902356001 9B Squash, summer-babyfood 0.006100 1.000 0.290 

0902357000 9B Squash, winter 0.006100 1.000 0.290 

0902357001 9B Squash, winter-babyfood 0.006100 1.000 0.290 

1100007000 11 Apple, fruit with peel 0.002000 1.000 0.100 

1100008000 11 Apple, peeled fruit 0.002000 1.000 0.100 

1100008001 11 Apple, peeled fruit-babyfood 0.002000 1.000 0.100 

1100009000 11 Apple, dried 0.002000 8.000 0.100 

1100009001 11 Apple, dried-babyfood 0.002000 8.000 0.100 

1100010000 11 Apple, juice 0.002000 1.000 0.100 

1100010001 11 Apple, juice-babyfood 0.002000 1.000 0.100 

1100011000 11 Apple, sauce 0.002000 1.000 0.100 

1100011001 11 Apple, sauce-babyfood 0.002000 1.000 0.100 

1100129000 11 Crabapple 0.002000 1.000 1.000 

1100173500 11 Goji berry 0.002200 1.000 1.000 

1100210000 11 Loquat 0.003000 1.000 1.000 

1100266000 11 Pear 0.003000 1.000 0.050 

1100266001 11 Pear-babyfood 0.003000 1.000 0.050 

1100267000 11 Pear, dried 0.003000 6.250 0.050 

1100268000 11 Pear, juice 0.003000 1.000 0.050 

1100268001 11 Pear, juice-babyfood 0.003000 1.000 0.050 

1100310000 11 Quince 0.003000 1.000 1.000 

1400003000 14 Almond 0.020000 1.000 0.010 

1400003001 14 Almond-babyfood 0.020000 1.000 0.010 

1400004000 14 Almond, oil 0.020000 1.000 0.010 

1400004001 14 Almond, oil-babyfood 0.020000 1.000 0.010 

1400059000 14 Brazil nut 0.020000 1.000 1.000 

1400068000 14 Butternut 0.020000 1.000 1.000 

1400081000 14 Cashew 0.020000 1.000 1.000 

1400092000 14 Chestnut 0.020000 1.000 1.000 

1400155000 14 Hazelnut 0.020000 1.000 1.000 

1400156000 14 Hazelnut, oil 0.020000 1.000 1.000 

1400185000 14 Hickory nut 0.020000 1.000 1.000 

1400213000 14 Macadamia nut 0.020000 1.000 1.000 

1400269000 14 Pecan 0.020000 1.000 1.000 

1400282000 14 Pistachio 0.020000 1.000 1.000 

1400391000 14 Walnut 0.020000 1.000 1.000 

2003128000 20C Cottonseed, oil 0.025000 1.000 0.010 

2003128001 20C Cottonseed, oil-babyfood 0.025000 1.000 0.010 

3100044000 31 Beef, meat 0.002000 1.000 0.100 

3100044001 31 Beef, meat-babyfood 0.002000 1.000 0.100 

3100045000 31 Beef, meat, dried 0.002000 1.920 0.100 

3100046000 31 Beef, meat byproducts 0.010000 1.000 0.100 

3100046001 31 Beef, meat byproducts-babyfood 0.010000 1.000 0.100 

3100047000 31 Beef, fat 0.003000 1.000 0.100 

3100047001 31 Beef, fat-babyfood 0.003000 1.000 0.100 

3100048000 31 Beef, kidney 0.004500 1.000 0.100 

3100049000 31 Beef, liver 0.010000 1.000 0.100 

3100049001 31 Beef, liver-babyfood 0.010000 1.000 0.100 

3200169000 32 Goat, meat 0.002000 1.000 0.100 

3200170000 32 Goat, meat byproducts 0.010000 1.000 0.100 

3200171000 32 Goat, fat 0.003000 1.000 0.100 

3200172000 32 Goat, kidney 0.004500 1.000 0.100 

3200173000 32 Goat, liver 0.010000 1.000 0.100 

3300189000 33 Horse, meat 0.002000 1.000 0.100 

3400290000 34 Pork, meat 0.002000 1.000 0.010 

3400290001 34 Pork, meat-babyfood 0.002000 1.000 0.010 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

______________________________________________________________________________________

Page 29 of 30 

3400291000 34 Pork, skin 0.010000 1.000 0.010 

3400292000 34 Pork, meat byproducts 0.010000 1.000 0.010 

3400292001 34 Pork, meat byproducts-babyfood 0.010000 1.000 0.010 

3400293000 34 Pork, fat 0.003000 1.000 0.010 

3400293001 34 Pork, fat-babyfood 0.003000 1.000 0.010 

3400294000 34 Pork, kidney 0.004500 1.000 0.010 

3400295000 34 Pork, liver 0.010000 1.000 0.010 

3500339000 35 Sheep, meat 0.002000 1.000 0.100 

3500339001 35 Sheep, meat-babyfood 0.002000 1.000 0.100 

3500340000 35 Sheep, meat byproducts 0.010000 1.000 0.100 

3500341000 35 Sheep, fat 0.003000 1.000 0.100 

3500341001 35 Sheep, fat-babyfood 0.003000 1.000 0.100 

3500342000 35 Sheep, kidney 0.004500 1.000 0.100 

3500343000 35 Sheep, liver 0.010000 1.000 0.100 

3600222000 36 Milk, fat 0.002000 1.000 0.100 

3600222001 36 Milk, fat-baby food/infant formu 0.002000 1.000 0.100 

3600223000 36 Milk, nonfat solids 0.000300 1.000 0.100 

3600223001 36 Milk, nonfat solids-baby food/in 0.000300 1.000 0.100 

3600224000 36 Milk, water 0.000300 1.000 0.100 

3600224001 36 Milk, water-babyfood/infant form 0.000300 1.000 0.100 

3600225001 36 Milk, sugar (lactose)-baby food/ 0.000300 1.000 0.100 

8601000000 86A Water, direct, all sources 0.000150 1.000 1.000 

8602000000 86B Water, indirect, all sources 0.000150 1.000 1.000 
Emamectin benzoate Dietary Exposure and Risk Assessment DP Number: D393838 

PC Code: 122806 

______________________________________________________________________________________

Page 30 of 30 

Attachment 6: Chronic Results File 

U.S. EPA Ver. 3.16, 03-08-d 

DEEM-FCID Chronic analysis for EMAMECTIN BENZOATE NHANES 2003-2008 2-day 

Residue file name: C:\Documents and Settings\NDODD\My Documents\DEEM Version 

3.16\emamectin benzoate 2013\EMAMECTINCHRONICCUCURBITS 121212.R08 

 Adjustment factor #2 used. 

Analysis Date 12-19-2012/12:54:01 Residue file dated: 12-19-2012/12:52:17 

Reference dose (RfD, Chronic) = .000075 mg/kg bw/day 

COMMENT 1: General Population; include pome fruits + drinking water 

=============================================================================== 

 Total exposure by population subgroup 

------------------------------------------------------------------------------- 

 Total Exposure 

 ----------------------------------- 

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- ---------------- 

Total US Population 0.000006 7.5% 

Hispanic 0.000005 7.0% 

Non-Hisp-White 0.000006 7.5% 

Non-Hisp-Black 0.000006 7.7% 

Non-Hisp-Other 0.000007 9.2% 

Nursing Infants 0.000006 7.5% 

Non-Nursing Infants 0.000014 19.0% 

Female 13+ PREG 0.000005 6.9% 

Children 1-6 0.000009 12.6% 

Children 7-12 0.000005 7.0% 

Male 13-19 0.000004 5.1% 

Female 13-19/NP 0.000004 5.2% 

Male 20+ 0.000005 6.8% 

Female 20+/NP 0.000006 7.6% 

Seniors 55+ 0.000006 7.5% 

All Infants 0.000012 15.5% 

Female 13-50 0.000005 6.8% 

Children 1-2 0.000011 15.3% 

Children 3-5 0.000009 11.5% 

Children 6-12 0.000006 7.4% 

Youth 13-19 0.000004 5.2% 

Adults 20-49 0.000005 6.9% 

Adults 50-99 0.000006 7.7% 

Female 13-49 0.000005 6.8% 

-------------------------------------------------------------------------