<PAGE>
 
                                                                   EXHIBIT 10.40
                                                                                




                AMENDED AND RESTATED DISTRIBUTORSHIP AGREEMENT

                                 March 1, 1998

                                    between

                      MOLECULAR SIMULATIONS INCORPORATED

                                      and

                   TEIJIN MOLECULAR SIMULATIONS INCORPORATED

                                       1
<PAGE>
 
                               TABLE OF CONTENTS
<TABLE>
<CAPTION>
                                                                                     Page
<S>                 <C>                                                              <C>   
1.   DEFINITIONS                                                            
     (a)            "Agreement"                                                         2
     (b)            "Customer"                                                          2  
     (c)            "Documentation"                                                     2
     (d)            "User Agreement"                                                    2
     (e)            "MSI Customers"                                                     2
     (f)            "Software"                                                          2
     (g)            "Subdistributor"                                                    2
     (h)            "Territory"                                                         2
     (i)            "Trademarks"                                                        2
 
2.   APPOINTMENT OF AUTHORIZED DISTRIBUTOR
     (a)            Distributor Rights                                                  2
     (b)            Limited Right to Use for Demonstration/Training/Support             3
     (c)            Right to Use Documentation                                          3
     (d)            Grant of Right to Distribute                                        3
     (e)            Right to Sell Consortia Membership                                  4
     (f)            Right to Sell Contract Research                                     4
     (g)            Web Sales                                                           5
     (h)            General Provisions                                                  5
     (i)            Exclusivity                                                         5
 
3.   ORDER PROCEDURE AND SHIPMENT AND DELIVERY TERMS
     (a)            Orders                                                              6
     (b)            Shipping and Delivery                                               7
     (c)            Cancellation of Orders                                              7
 
4.   PRICES AND PAYMENT TERMS
     (a)            Prices                                                              7
     (b)            Taxes                                                               7
     (c)            Payment Schedule                                                    8
     (d)            Installation Fees                                                   8
     (e)            Maintenance Fees                                                    8
     (f)            Discounts to Subdistributors and Customers                          8
     (g)            Hardware                                                            8
 
5.   OBLIGATIONS AND FUNCTIONS OF THE COMPANY                                           9
     (a)            Management and Support of Distribution                              9
     (b)            Relationship with Subdistributors                                   9
     (c)            Adequate Company Facilities and Customer Satisfaction               9
     (d)            Promotion and Marketing                                             9
</TABLE>
<PAGE>
<TABLE>
<CAPTION>
<S>                <C>                                                               <C> 
     (e)            Contract Services                                                   9
     (f)            Porting                                                             9
     (g)            OEM Arrangements                                                   10
     (h)            Company's General Businesslike Conduct                             10
     (i)            Technical Support and Other Staff                                  10
     (j)            Installation                                                       10
     (k)            Keeping MSI Informed                                               10
     (l)            Reports and Forecasts                                              10
     (m)            Competing Representations                                          10
 
6.   OBLIGATIONS OF MSI
     (a)            Availability of Documentation                                      11
     (b)            Training                                                           11
     (c)            Developments                                                       11
     (d)            Third Party OEM Arrangements                                       11
     (e)            Maintenance Upon Termination                                       11
     (f)            Bug Fixes                                                          11
 
7.   WARRANTIES, DISCLAIMERS AND LIMITATIONS OF LIABILITY
     (a)            MSI's Warranty                                                     12
     (b)            Warranty Disclaimers and Limitations                               12
     (c)            No Warranty Pass-Through                                           12
     (d)            Limitation of Liability                                            12
 
8.   INDEMNITY
     (a)            Proprietary Rights                                                 13
     (b)            Other Indemnity                                                    13
 
9.   PROPRIETARY RIGHTS
     (a)            Ownership of Proprietary Rights                                    14
     (b)            No Modification                                                    14
     (c)            Trademarks and Trade Names                                         14
     (d)            Nondisclosure and Non-Use                                          15
 
10.  COMPLIANCE WITH LAWS
     (a)            Export Law Compliance                                              16
     (b)            Foreign Corrupt Practices Act                                      16
     (c)            Licenses and Permits                                               16
 
11.  EFFECTIVE DATE, TERM, TERMINATION AND EFFECT OF
     TERMINATION
     (a)            Effective Date                                                     17
     (b)            Term                                                               17
     (c)            Termination by Either Party                                        17
     (d)            Termination by MSI                                                 17
</TABLE>
<PAGE>
<TABLE>
<S>               <C>                                                                <C> 
     (e)            No Other Rights Upon Termination                                   17
     (f)            Effect of Termination                                              17
     (g)            The Company's Duties Upon Termination                              18
 
12.  GENERAL TERMS                                                                     19
     (a)            Assignment                                                         19
     (b)            Benefits and Binding Nature of Agreement                           19
     (c)            Entire Agreement                                                   19
     (d)            Force Majeure                                                      19
     (e)            Notice                                                             19
     (f)            Governing Law and Official Language                                19
     (g)            Dispute Resolution                                                 20
     (h)            Waiver                                                             20
     (i)            Severability                                                       21
     (j)            Rights and Remedies Cumulative                                     21
     (k)            No Agency - Independent Contractors                                21
     (l)            Captions and Section References                                    21
     (m)            Counterparts                                                       21
     (n)            No Limitation on Supplier MSI                                      21
     (o)            Parties Advised by Counsel -- No Interpretation Against Drafter    21
     (p)            Authority to Enter Into and Execute Agreement                      21
</TABLE>

APPENDICES

     Appendix A:  Software, Consortia and Price Lists
     Appendix B:  MSI Standard User Agreement
     Appendix C:   Wire Transfer (Bank) Information
     Appendix D:   MSI Trademarks
     Appendix E:  List of WebLab Products Available From MSI's Web Page
<PAGE>
 
                AMENDED AND RESTATED DISTRIBUTORSHIP AGREEMENT

     This Amended and Restated Distributorship Agreement  ("Agreement") is made
and entered into effective as of the 1st day of March, 1998, by and between
Molecular Simulations Incorporated, a Delaware corporation, having its principal
place of business at 9685 Scranton Road, San Diego, CA 92121, U.S.A. ("MSI") and
Teijin Molecular Simulations Incorporated, a corporation organized under the
laws of Japan, with its principal place of business at 1-1, Uchisaiwai-cho 2-
chome, Chiyoda-ku, Tokyo 100, Japan ("the Company").

                                   RECITALS

     A.  MSI (formerly Polygen Corporation doing business as Polygen Molecular
Simulations Incorporated) and Teijin Limited, a corporation organized under the
laws of Japan with its principal office at 6-7, Minamihommachi 1-chome, Chuo-ku,
Osaka 541, Japan ("Teijin") have entered into a Joint Venture Agreement dated as
of February 14, 1992 (the "Joint Venture Agreement"), pursuant to which the
Company was organized as a joint venture corporation under the laws of Japan.

     B.  MSI and its subsidiaries are engaged in the design, development and
distribution of proprietary computational chemistry software products and
related documentation.

     C.  It was contemplated by MSI and Teijin under the Joint Venture Agreement
that the Company be appointed as MSI's exclusive distributor in the Territory
(as defined below) of the Software (as defined below).

     D.  On or around February   1992, MSI granted to the Company an exclusive
right to market and distribute the Software and related documentation in the
Territory, subject to the terms and conditions set forth in  a distribution
agreement of that date (the "Distribution Agreement"). The Distribution
Agreement has since been amended pursuant to an Amendment to Distributorship
Agreement dated October _, 1994, and by an Amendment No. 2 to Distributorship
Agreement dated September , 1996. In consideration of the rights granted to the
Company under Amendment No.2 , , the Company paid to MSI [*].

     E.  MSI and Teijin now wish to amend and restate the Distributorship
Agreement in its entirety, so that the prior Distributorship Agreement shall be
superseded hereby and the agreement of the parties shall read in full as set
forth in this Agreement.

     THEREFORE, in consideration of the premises and mutual covenants herein
contained, the parties hereto agree as follows:


* CONFIDENTIAL TREATMENT REQUESTED

                                       1
<PAGE>
 
                                   AGREEMENT

1.   DEFINITIONS.

     For the purpose of this Agreement, the following terms shall have the
following meanings unless otherwise required by the context:

     (a) "Agreement" shall mean this Amended and Restated Distributorship
          ---------                                                      
Agreement as it may be amended from time to time.

     (b) "Customer" shall mean any third party user to whom the Company has, in
          --------                                                             
accordance with the terms of this Agreement and the User Agreement, granted the
right to use the Software.

     (c) "Documentation" shall mean the standard user documentation and sales
          -------------                                                      
support materials which MSI has published or may publish during the term of this
Agreement.

     (d) "User Agreement" shall mean a standard user agreement, a sample of
          --------------                                                   
which is attached as Appendix B, pursuant to which Customers are granted by the
Company a limited right to use the Software.

     (e) "MSI Customers" shall mean any third party user in the Territory to
          -------------                                                     
whom MSI or MSI's agent has granted the limited right to use the Software prior
to the effective date of the Distribution Agreement.

     (f) "Software" shall mean the computational chemistry software products
          --------                                                          
marketed by MSI or MSI's subsidiaries and distributed hereunder, to be provided
in machine readable (object code) form, and set forth on Appendix A attached
hereto, as such Appendix A may be amended from time to time by MSI and the
Company in accordance with Section 2(a) below.

     (g) "Subdistributor" shall mean any subdistributor, agent or value-added
          --------------                                                     
reseller authorized by the Company to distribute the Software.

     (h) "Territory" shall mean the following countries: Japan, South Korea,
          ---------                                                         
Taiwan, Hong Kong, China, India, Singapore, Malaysia, Australia and New Zealand.

     (i) "Trademarks" shall mean any trademark which MSI owns or has the right
          ----------                                                          
to use as may be designated by MSI from time to time.

2.   APPOINTMENT OF AUTHORIZED DISTRIBUTOR.

     (a) Distributor Rights. Subject to the terms and conditions contained
         ------------------                                               
herein, MSI hereby grants to the Company, and the Company hereby accepts, the
exclusive, non-transferable and indivisible right to market the Software in the
Territory during the term hereof solely for distribution to Customers located in
the Territory. The Company shall have no right to assign or

                                       2
<PAGE>
 
otherwise transfer any or all of its rights under this Agreement except as may
be otherwise provided in Section 2(d) hereof with respect to the distribution to
Customers. It is the intention of the parties to amend Appendix A of this
Agreement from time to time to include within the definition of "Software" under
this Agreement, all computational chemistry software products that are developed
or marketed by MSI or its subsidiaries in the future during the term of this
Agreement, including extensions of, replacements for, or improvements of the
software products presently enumerated on Appendix A; provided, however, that
MSI may at its option exclude from "Software" and the scope of this Agreement,
software products for which it does not have distribution rights for the
Territory due to limitations or restrictions imposed by the supplier or party
providing such software products to MSI. Notwithstanding the grant of
exclusivity under this Section 2(a), MSI may, upon prior notice to the Company
distribute Software to third parties outside the Territory who will bundle the
Software with hardware and distribute those bundled products in the Territory,
provided that such bundling shall be on an OEM basis.

     (b) Limited Right to Use for Demonstration/Training/Support. MSI hereby
         -------------------------------------------------------            
grants and the Company hereby accepts, subject to the terms and conditions
specified herein, an exclusive right, except for rights to use the Software for
demonstration and support activities that have been or may be granted by MSI to
OEM's or computer manufacturers, to use in the Territory, during the term
hereof, the Software for demonstration and technical support of the Software,
and for training of Company and Subdistributor personnel on the Software.

     (c) Right to Use Documentation. MSI hereby grants and the Company hereby
         --------------------------                                          
accepts, subject to the terms and conditions specified herein, an exclusive
right, except for rights to use the Documentation for demonstration and support
activities that have been or may be granted by MSI to OEM's or computer
manufacturers, to use the Documentation in the Territory during the term hereof
for the purpose of enabling the Company to carry out its distribution and
support obligations to MSI Customers and Customers under this Agreement. The
Company may, at its expense, translate, copy and repackage the Documentation as
is necessary in connection with its distribution of the Software pursuant to
Section 2(d) hereof. All translations of the Documentation shall, pursuant to
Section 2(e)(i) hereof, include MSI copyright and other proprietary rights
notices. MSI shall retain title to and ownership of any such translations of the
Documentation.

     (d) Grant of Right to Distribute.
         ---------------------------- 

         (i)   The rights granted under this Agreement are non-transferable,
     except that the Company is hereby authorized to grant rights to Customers
     of the Company or to Customers of Subdistributors for use of the Software
     on any appropriate platform on the terms and conditions set forth below.
     Rights to use the Software may only be granted to Customers who represent
     that they shall not use the Software to provide any service bureau or
     consulting service to any third party, or to re-export the Software without
     first obtaining written permission from MSI. Software provided to Customers
     shall be in machine-readable (object) code.

                                       3
<PAGE>
 
         (ii)  Until termination of this Agreement, the Company shall distribute
     and provide the Software and Documentation to Customers pursuant only to
     the terms of an User Agreement. Promptly following the execution of this
     Agreement, the Company shall, at its expense, develop an User Agreement in
     the Japanese language, together with an English language translation of the
     same, which User Agreement shall contain terms that are substantially
     equivalent to those set forth in MSI's standard  UserAgreement (Appendix B
     hereto). Without prejudice to the generality of the foregoing, and in
     addition to such terms, the User Agreement shall expressly provide that:
     (x) the User Agreement (and any related software maintenance agreement)
     between the Customer and the Company shall be automatically assigned to MSI
     or MSI's designee in the event of termination of this Agreement for any
     reason, and (y) the terms of the User Agreement shall govern and control in
     the event of any inconsistency between its terms and those of any purchase
     order between the Customer and the Company. The Company shall provide MSI
     with copies of its User Agreement and the English translation thereof for
     MSI's written approval. The Company shall not transfer Software to a
     Customer unless and until the Company shall have obtained a signed copy of
     the User Agreement from the Customer, and the Company agrees to obtain
     prior written approval from MSI to any modifications or changes to the pre-
     approved User Agreement.

         (iii) The Company agrees to use its reasonable commercial efforts to
     ensure that each Customer granted a right to use the Software pursuant to
     this Agreement continues to comply with the terms of the User Agreement.
     The Company shall maintain adequate Customer records which may be inspected
     by MSI during regular business hours upon reasonable prior written notice.

     (e) Right to Sell Consortia Membership. The Company may  sell to Customers
         -----------------------------------                                   
within the Territory membership rights in any of  MSI's various consortia. A
list of the current consortia, along with the price of membership for each, is
included in Appendix A("Consortia"). It is the intent of the parties to amend
Appendix A from time to time to include within the definition of Consortia any
new or extended consortia that may be established or extended by MSI. The
Company agrees that it will, at its expense, develop in the Japanese language
consortium agreements which contain terms substantially equivalent  to those set
forth in MSI's standard consortium agreements but which show the Company or its
subdistributors (rather than MSI) as the contracting party with Customer.
Company will ensure that all Customers wishing to participate in a consortium
sign such an agreement. Company hereby subcontracts all its rights and
obligations under the consortia agreements to MSI and  MSI agrees that it will
perform all services required of Company under such agreements with Customers
provided that such obligations are no more onerous than those MSI assumes in its
standard consortia agreements.

     (f) Right to Sell Contract Research. Company may enter into consulting
         --------------------------------                                  
research contracts with Customers within the Territory pursuant to which Company
will agree to perform a certain research or consulting services project for a
Customer. For purposes of this Agreement contract research shall mean the
services offered by MSI which (i) apply MSI Software to a customer research
problem or project, or (ii) develop custom software to a customer's
specifications. Company will subcontract the work to be performed under such a
contract to MSI

                                       4
<PAGE>
 
if MSI accepts the work. Before entering into such a contract, however,  Company
shall first have transmitted to MSI full details of Customer's proposal
including but not limited to a description of the project and the time period
within which the project must be performed. MSI will then consider the proposal
and, if it believes that it can satisfactorily and timely complete the project,
it will give Company a quote of its prices for performing the work, along with
any other conditions or qualifications which MSI believes are necessary to
enable it to complete the project. Upon receipt of the quote Company may then
enter into a research contract with the Customer on terms consistent with the
conditions and qualifications specified by MSI.

     (g) Web sales. Certain of MSI's WebLab family of products are now available
         ---------                                                              
for sale over the worldwide internet such that Customers, both inside and
outside the Territory, may purchase rights to use such WebLab products directly
from MSI's web page. A list of such products is attached hereto as Appendix E.
Appendix E may be updated from time to time. MSI agrees that with respect to all
sales of WebLab products made to Customers within the Territory directly from
MSI's web page, MSI will pay to the Company [*]of all Fees received by MSI.
"Fee" means the price or fee that MSI actually receives when MSI makes a sale
from its web page after deducting (i) trade or quantity discounts allowed or
taken; (ii) actual credits or refunds to customers on account of any returns of
such products; (iii) any insurance, shipping or other out-of-pocket expense that
may be incurred in connection with delivery; (iv) any excise, sales, value-
added, property  and use taxes; and (v) import and export duties, taxes
(including foreign withholding taxes) and surcharges. These Fees will be paid by
MSI on a quarterly basis no later than the [*] day after the end of each
calendar quarter.

     (h) General Provisions. All rights granted herein shall be further subject
         ------------------                                                    
to the following:

         (i)   The Software and Documentation and any copies thereof shall in
     all cases remain the exclusive property of MSI.

         (ii)  Except as expressly set forth in Sections 2(c) and 6(a) hereof,
     the Company agrees not to copy, provide, or otherwise make available any of
     the Software or Documentation, in whole or in part in any form, to any
     person other than employees of the Company, Subdistributors and Customers
     as provided for in this Section 2. The Company agrees to take appropriate
     action by instruction, agreement, or otherwise with the Company's employees
     or other persons permitted access hereunder to the Software or
     Documentation to satisfy its obligations under this Agreement with respect
     to the use, copying, modification, protection, and security of the Software
     and Documentation.

         (iii) The Company agrees not to ship any Software to any person in the
     Territory which the Company knows or has reason to know, based upon
     information provided to it by the Customer at the time of grant of such
     right, will cause or permit the Software ultimately to be shipped or used
     outside of the Territory.

     (i) Exclusivity. The grant by MSI to the Company of certain "exclusive"
         -----------                                                        
rights with respect to the Territory shall mean that, unless otherwise expressly
permitted herein, MSI shall

* CONFIDENTIAL TREATMENT REQUESTED


                                       5
<PAGE>
 
have no right to, directly or indirectly, exercise, or permit third parties to
exercise, those rights in the Territory. This shall mean, without limitation,
that, without the express written consent of the Company, MSI:

         (i)   shall not itself ship any Software to any person in the
     Territory; and

         (ii)  shall not ship any Software to any person outside of the
     Territory which MSI knows or has reason to know, based upon information
     provided to it by the Customer at the time of grant of such right, will
     cause or permit the Software ultimately to be shipped, or used in the
     Territory;

         (iii) provided, however, that MSI may:

                    (x) grant rights to OEM or computer manufacturers to use the
               Software and Documentation for demonstration and support
               activities; and

                    (y) grant a right to third parties outside of the Territory;
               provided, however, that in the event MSI grants a right to a
               third party located outside of the Territory that has
               subsidiaries or facilities in the Territory, and if, at the time
               of entering into such transaction, MSI has a reasonable belief
               that a significant level (if any) of software will be shipped
               into the Territory as a consequence of such transaction, MSI and
               the Company shall determine in good faith the manner in which
               revenues arising from such third party transaction are to be
               divided between MSI and the Company. Similarly, in the event the
               Company grants a right to a third party located in the Territory
               that has subsidiaries or facilities outside of the Territory, and
               if, at the time of entering into such transaction, the Company
               has a reasonable belief that a significant level (if any) of
               software will be shipped outside of the Territory as a
               consequence of such transaction, the Company and MSI shall
               determine in good faith the manner in which revenues arising from
               such third party transaction are to be divided between the
               Company and MSI.

     MSI shall cause MSI's subsidiaries to comply with the foregoing provisions
     and limitations with respect to any Software which they have, directly or
     indirectly, distributed to the Company hereunder.

3.   ORDER PROCEDURE AND SHIPMENT AND DELIVERY TERMS.

     (a) Orders. The Company shall submit written purchase orders for Software
         ------                                                               
in accordance with the then current order processing procedures of MSI as
designated from time to time by MSI. All purchase orders placed with MSI for
Software shall be subject to acceptance by MSI at its principal place of
business, such acceptance not to be unreasonably withheld. MSI shall use
reasonable efforts to meet the resale requirements of the Company and to make
deliveries in accordance with the delivery date on orders so accepted, but MSI
shall not be liable to the

                                       6

<PAGE>
 
Company, any Subdistributor or Customer or to any other party, for MSI's delay
in delivery or failure to deliver any products that are under development by MSI
at the time an order is received.

     (b) Shipping and Delivery. The following shipping and delivery procedures
         ---------------------                                                
shall apply to Software and Documentation ordered by the Company from MSI
pursuant to Section 3(a) above. Deliveries shall be made F.O.B. (as defined in
Incoterms 1990, Publ. No. 460 of the International Chamber of Commerce) from
MSI's warehouse or manufacturing facility, and shall be shipped to the Company
at Hamacho-Hanacho Bldg. 4F. 2-17-8 Nihonbashi Hamacho Chuo-ku, Tokyo 103-0007
Japan. Unless the Company's order specifies the name of a carrier, MSI will
select the carrier. MSI shall bear the risk of loss until such time as a
shipment has been placed on board the carrier, at which time the risk of loss
shall be borne by the Company. Any claims for damage or loss in transit shall be
placed by the Company through the carrier. All shipments will be shipped by MSI
freight collect, or if prepaid, such freight will be subsequently billed to the
Company, and the Company will reimburse MSI for such freight in accordance with
Section 4 below. MSI reserves the right to deliver in advance of estimated
delivery dates.

     (c) Cancellation of Orders. The Company may cancel any order (or part
         ----------------------                                           
thereof) for Software by giving MSI written notice of such cancellation.

4.   PRICES OF PRODUCTSAND PAYMENT TERMS.

     (a) Price. The Company agrees to pay MSI the prices specified in MSI's
         -----                                                             
price list attached to this Agreement in Appendix A (the "Price List"), as in
effect when each order is accepted by MSI, less an initial discount of [*] of
such Price List for the period ending on[*]; such discount to be re-negotiated
annually in good faith by MSI and the Company. The re-negotiated discount will
be reflected in the minutes of the Board meeting at which such discount is
agreed. Such prices are exclusive of, and the Company shall pay, all shipping
charges for each order. MSI agrees to give written notice to the Company at
least ninety (90)days in advance of the effective date of any change in its
Price List. Such changes in MSI's Price List shall be made no more frequently
than once during each calendar year, shall be made only after consultation with
the Company, and shall be commercially reasonable.

     (b) Taxes. Any and all fees and other amounts due to MSI from the Company
         -----                                                                
under this Agreement are exclusive of, and the Company shall pay and shall
indemnify and hold MSI harmless against (i) any liability for, any sales, use,
property, license, value added, withholding, import, excise or similar tax,
federal, state or local, U.S. and non-U.S., that may be imposed upon or with
respect to the Software products or their delivery, sale, distribution, use,
ownership or possession, and (ii) any duties, tariffs, customs, import and
related fees and charges, exclusive of taxes based on MSI's net income.
Notwithstanding the foregoing, Japanese income tax may be withheld by the
Company from the price payable to MSI pursuant to Section 4(a) hereof, so long
as such withholding is required by Japanese law. The Company shall provide MSI
with copies of tax receipts or other documents evidencing that such taxes
withheld have been paid to the Japanese tax authorities. Such evidence shall be
forwarded to MSI no later than thirty (30) days after such taxes have been paid.

* CONFIDENTIAL TREATMENT REQUESTED

                                       7
 
<PAGE>
 
     (c) Payment Schedule. MSI shall invoice the Company each time Software is 
         ----------------                       
shipped in accordance with the Price List attached hereto as Appendix A. The
Company will make payment to MSI by the fifth (5th) business day of the second
month following the month in which shipments are made by MSI to the Company or
its customers.. Payment will be Japanese Yen for sales in Japan and in U.S.
dollars for sales in all other AP countries, and will be made by wire transfer
of immediately available funds to such bank account as is specified in Appendix
D attached hereto, as may be revised from time to time by MSI. For those
Customers who join any of MSI's consortia, MSI will invoice the Company at the
beginning of each work year of the term of each consortium for the price of
annual membership for each of the Company's Customers. Invoicing and payment
terms for contract research Customers will be determined by MSI and the Company
on a case by case basis, but in any event, no later than thirty (30) days after
the date the work is completed. Invoices shall be considered paid when MSI is in
receipt of such funds or upon confirmation of receipt by the bank. From and
after the date of any default of any payment due hereunder, until such default
is cured, interest shall accrue at the rate of two percent (2%) per month on
such unpaid amounts, or at the maximum rate permitted by California law, if
less.

     (d) Installation Fees. The Company may not charge Customers installation
         -----------------                                                   
fees except as set forth in Appendix A or as otherwise approved in writing by
MSI.

     (e) Maintenance Fees. For each Software product, maintenance and updates
         ----------------                                                    
shall be provided by the Company, on behalf of MSI, to MSI Customers and
Customers. This maintenance service shall be provided to MSI Customers and
Customers in accordance with MSI's policies.. Unless and until the maintenance
pricing shall be adjusted by MSI in accordance with the terms of this Agreement,
the maintenance pricing to be paid to MSI for a given Software product shall
conform to the maintenance pricing schedule shown in attached Appendix A, less
an initial discount of [*] to be retained by the Company for the period ending
on [*]; such discount to be re-negotiated annually in good faith by MSI and the
Company and to be reflected in the minutes of the Board meeting at which such
discount is agreed. Unless otherwise agreed, the fee for the annual maintenance
contracts and their renewals shall be paid in advance of the effective date or
renewal date thereof (as the case may be) by the Company to MSI.

     (f) Discounts to Subdistributors and Customers. Nothing contained herein
         ------------------------------------------                          
shall prevent or otherwise limit the Company's ability to grant additional
discounts to Subdistributors and/or Customers; provided, however, that all such
discounts are and shall be borne entirely by the Company or its Subdistributor.

     (g) Hardware. MSI shall sell to the Company workstations manufactured by
         --------                                                            
Silicon Graphics Inc. ("SGI") at [*] of the Japanese list price for the period
ending on [*]. Thereafter, MSI shall use reasonable commercial efforts to extend
or continue its existing relationships with SGI and other value-added reseller
hardware vendors in order to offer and sell such hardware to the Company at a
favorable price. The Company agrees to purchase such hardware from MSI as long
as MSI is able to offer such hardware at prices equal to or more favorable than
prices available to the Company from other sources.

* CONFIDENTIAL TREATMENT REQUESTED

                                       8
<PAGE>
 
5.   OBLIGATIONS AND FUNCTIONS OF THE COMPANY.

     (a) Management and Support of Distribution. The Company shall be
         --------------------------------------                      
responsible for managing and supporting the distribution of the Software in the
Territory, including the management of Subdistributors and value-added reseller
relationships.

     (b) Relationship with Subdistributors. The Company may, in its reasonable
         ---------------------------------                                    
discretion, appoint and authorize Subdistributors to subdistribute the Software
in the Territory. In doing so, the Company shall enter into agreements or
arrangements with such Subdistributors that maximize, and shall act to the best
interests of, the distribution and support of the Software in the Territory. The
Company shall use reasonable commercial efforts to ensure compliance by such
Subdistributors with all of the Company's obligations under this Agreement, and
at all times transact with such Subdistributors on an arms'-length basis.

     (c) Adequate Company Facilities and Customer Satisfaction. The Company will
         -----------------------------------------------------                  
establish, staff, equip and maintain such place or places of business in such
location or locations in the Territory as may be necessary to provide good
Customer service and support and marketing coverage in the Territory. The
Company shall use its best efforts to ensure Customer satisfaction including
maintaining a qualified sales force to promote the sale/distribution of the
Software.

     (d) Promotion and Marketing. The Company agrees to use its best efforts to
         -----------------------                                               
market, distribute, and support the Software throughout the Territory and
further agrees that its marketing and advertising efforts will be of high
quality, in good taste, and will preserve the professional image and reputation
of MSI and the Software. The Company agrees to include in all related
advertising materials all applicable proprietary rights' notices and any other
notices of MSI as they appear on or in the Software. MSI may provide, at its
option, a reasonable amount of advertising material in English, as requested by
the Company, for use in the Company's efforts to market the Software. All such
material shall remain the property of MSI and, upon request, the Company agrees
to return same to MSI without cost to MSI. If required by Customer demand, the
Company shall translate all such materials into the Japanese language or other
language necessary for proper marketing of the Software in the Territory and
provide such materials to MSI for review. MSI shall retain title to and
ownership of any such translations. The Company agrees to refrain from making
any claim or representation concerning the Software in excess of those made by
MSI.

     (e) Contract Services. The Company may enter into application contracts
         -----------------                                                  
with MSI Customers or Customers whereby the Company will provide services to
address Customer problems related to the use of the Software in the Territory.
The Company may also act as MSI's agent with respect to the development or
establishment of strategic technology partner (STP) relationships with major
Customers and MSI Customers in the Territory.

     (f) Porting. The Company shall act as MSI's agent with respect to
         -------                                                      
establishing and managing porting contracts with computer companies in the
Territory. MSI agrees to use its best commercial efforts to supply information
necessary to complete porting that is reasonably requested by the Company.

                                       9

<PAGE>
 
     (g) OEM Arrangements. The Company shall endeavour to establish OEM
         ----------------                                              
arrangements with third parties in the Territory, and MSI agrees to use its best
commercial efforts to supply information necessary to establish such
arrangements.

     (h) Company's General Businesslike Conduct. The Company shall at all times
         --------------------------------------                                
conduct its business in a businesslike manner and will not engage in any
deceptive, misleading, illegal or unethical business practice or any practice
that will reflect unfavorably on MSI or the Software.

     (i) Technical Support and Other Staff. The Company agrees to develop,
         ---------------------------------                                
maintain and train or otherwise provide a competent technical and scientific
support organization for the Software that will be responsible for the
installation and on-site servicing of the Software, the provision of remote
telephone support services, and the provision of training and application
development to MSI Customers, Customers and Subdistributors. The Company shall
at all times have a sufficient number of competent office, sales, service and
other employees to carry out its obligations under this Agreement.

     (j) Installation. The Company shall be responsible for the installation of
         ------------                                                          
the Software at Customers' facilities, either directly or through
Subdistributors.

     (k) Keeping MSI Informed. The Company agrees to use its best efforts to
         --------------------                                               
keep MSI fully informed of all governmental, commercial and industrial
activities and plans which affect, or could affect, the Software in the
Territory. The Company shall consult with MSI regarding any advertising or trade
practice which might affect the good name, trademarks, goodwill, or reputation
of MSI or the Software.

     (l) Reports and Forecasts. The Company shall furnish to MSI in English: (i)
         ---------------------                                                  
within eight (8) business days after the end of each calendar month, a report on
the monthly sales and distribution of the Software in the Territory for the
preceding month, identifying the Software shipped by the Company or
Subdistributors to Customers and the respective locations and contact persons of
such Customers, and showing the price and national currency involved in which
the Software was sold/distributed and for which services relating thereto were
provided, and (ii) a rolling six (6)-month forecast of sales on a monthly basis.
The Company shall also furnish MSI with such other reports as MSI may reasonably
require from time to time.

     (m) Competing Representations The Company agrees that during the term of
         --------------------------                                          
this Agreement, the Company shall not develop, contract to develop, manufacture,
sell, lease or otherwise distribute or exploit in any manner any product that is
directly competitive with the Software in the Territory. For the purposes of
this Agreement, a product shall be considered to be competitive with the
Software if the sale of that product could result in lower sales of the
Software.

                                      10

<PAGE>
 
6.   OBLIGATIONS OF MSI.

     (a) Availability of Documentation. MSI shall provide the Company with one
         -----------------------------                                        
(1) copy of all Documentation in the English language including sales
literature, training manuals, operator manuals, graphic materials, and other
documentation relating to the Software. The Company may translate, copy, and
repackage the Documentation as is necessary in accordance with the terms of
Section 2(c) above.

     (b) Training. MSI will provide intensive training for a reasonable number
         --------                                                             
of the Company's personnel at MSI's facilities in the U.S.A., for a reasonable
number of days per year. The Company shall pay all travel, living and incidental
expenses of its personnel. MSI shall also provide technical instructors for
seminars to be held in Japan on a periodic basis, subject to the availability
and reasonable schedules of such instructors. All travel, living and incidental
expenses of such instructors shall be borne by the Company.

     (c) Developments. During the term of this Agreement, MSI will use
         ------------                                                 
reasonable commercial efforts to provide the Company with full and complete
information concerning all improvements, updates, enhancements, and
modifications to the Software and will provide the Company with such
improvements, updates, enhancements and modifications for distribution to
Customers at the same time as MSI makes any such improvement, update,
enhancement or modification generally available to its other Customers. In
addition, if there is any software product which is under development by MSI
which may be added to the definition of "Software" pursuant to Section 2(a)
hereof, MSI shall use its reasonable commercial efforts to provide the Company,
on a regular basis as it becomes available, with full and complete information
concerning such product, including, but not limited to, the projected
development and shipping schedule, beta release, documentation and other
information that would assist with pre-marketing preparation.

     (d) Third Party OEM Arrangements. In the event that MSI enters into an OEM
         ----------------------------                                          
arrangement with a third party relating to the manufacture and distribution of
bundled MSI software and third party hardware products (as contemplated under
Section 2(a) hereof), which arrangement includes distribution by such third
party in the Territory being served by the Company, MSI agrees to negotiate in
good faith with the Company to have the Company provide technical support for
such bundled products in the Territory (if necessary). MSI shall give advance
written notice to the Company of such OEM arrangements if support by the Company
is necessary.

     (e) Maintenance Upon Termination. Upon the termination of this Agreement
         ----------------------------                                        
and provided that the relevant User Agreements have been assigned to MSI or its
designee in accordance with Section 11(f)(iii) hereof, MSI shall use its best
efforts to arrange for the continued maintenance and support of MSI Customers,
Customers and the Software in the Territory.

     (f) Bug Fixes. MSI will use its reasonable commercial efforts to notify the
         ---------                                                              
Company in writing of any outstanding bugs or other defects in the Software and
will endeavour to correct

                                      11
 
<PAGE>

such bugs and defects and supply such corrections to the Company in accordance
with MSI's reasonable commercial procedures.

7.   WARRANTIES, DISCLAIMERS AND LIMITATIONS OF LIABILITY.

     (a) MSI's Warranty. All Software is warranted as provided in Section 5 of
         --------------                                                       
the current form of MSI's standard UserAgreement attached hereto as Appendix B,
the provisions of which are made a part hereof by reference.

     (b) Warranty Disclaimers and Limitations. THE WARRANTIES DESCRIBED IN 7(a)
         ------------------------------------                                  
ABOVE ARE EXCLUSIVE AND IN LIEU OF ALL OTHER WARRANTIES, WHETHER EXPRESS OR
IMPLIED, INCLUDING, BUT NOT LIMITED TO, THE IMPLIED WARRANTIES OF
MERCHANTABILITY, FITNESS FOR A PARTICULAR PURPOSE AND NON-INFRINGEMENT. The
warranties shall apply only if MSI's examination discloses to MSI's satisfaction
that alleged defects actually exist and were not caused by misuse, unauthorized
modifications, neglect, improper installation or testing, attempts to repair, or
the like, or by accident, fire, power surge or failure, or other hazard.

     (c) No Warranty Pass-Through. The Company shall not pass through to its
         ------------------------                                           
Customers or any other third party the warranties made by MSI under this Section
7, shall make no other representations to its Customers or any other third party
on behalf of MSI, and shall expressly indicate to its Customers that they must
look solely to the Company in connection with any problems, warranty, claim or
other matters concerning the Software. No warranty, representation or agreement
herein shall be deemed to be made for the benefit of any Customer or any other
third party. Notwithstanding the foregoing, the Company may pass through only to
Customers only those warranties specified in Section 10 of the attached MSI
Standard Software Agreement (Appendix B hereto). Repair or replacement of code
or other items does not extend the warranty period beyond the initial warranty
period which shall begin on the date of installation of the Software at the
Customer's facilities.

     (d) Limitation of Liability. IN NO EVENT SHALL EITHER PARTY BE LIABLE FOR
         -----------------------                                              
ANY INDIRECT, INCIDENTAL, SPECIAL OR CONSEQUENTIAL DAMAGES, INCLUDING LOSS OF
PROFITS, REVENUE, DATA, OR USE, INCURRED BY EITHER PARTY OR ANY THIRD PARTY,
WHETHER IN AN ACTION IN CONTRACT OR TORT OR BASED ON A WARRANTY, EVEN IF THE
OTHER PARTY OR ANY OTHER PERSON HAS BEEN ADVISED OF THE POSSIBILITY OF SUCH
DAMAGES. MSI'S LIABILITY FOR ANY DAMAGES UNDER THIS AGREEMENT SHALL IN NO EVENT
EXCEED THE AMOUNTS ACTUALLY PAID BY THE COMPANY TO MSI UNDER THIS AGREEMENT.
SOME STATES AND JURISDICTIONS OUTSIDE OF THE UNITED STATES DO NOT ALLOW THE
LIMITATION OR EXCLUSION OF IMPLIED WARRANTIES, OR LIABILITY FOR INCIDENTAL OR
CONSEQUENTIAL DAMAGES, SO THE ABOVE LIMITATION OR EXCLUSION MAY NOT APPLY. THE
COMPANY ACKNOWLEDGES THAT THE ALLOCATION OF RISKS AND BENEFITS UNDER THIS
AGREEMENT ARE BASED ON, AND THE PRICESUNDER THIS AGREEMENT WOULD BE GREATER IN
THE ABSENCE OF, THE LIMITATIONS DESCRIBED ABOVE.

                                       12
 
<PAGE>

8.   INDEMNITY.

     (a) Proprietary Rights. MSI will defend the Company against a claim that
         ------------------                                                  
the Software furnished and used within the scope of this Agreement infringes any
third party patent, copyright or other intellectual property right ("Claim"),
and MSI will indemnify the Company for any damages finally awarded by a court of
competent jurisdiction based upon a Claim, or any amount that is paid to finally
settle a Claim, so long as MSI has approved the settlement in writing, provided
that: (i) the Company notifies MSI in writing within thirty (30) days of any
Claim, (ii) MSI has sole control of the defense and all related settlement
negotiations, and (iii) the Company provides MSI with the assistance,
information and authority necessary to perform the above. Reasonable out-of-
pocket expenses incurred by the Company in providing such assistance will be
reimbursed by MSI.

         (i)   Notwithstanding the foregoing, MSI shall have no liability for
     any claim of patent or copyright infringement based on: (A) a modification
     by the Company of the Software or the use of a superseded or altered
     release of the Software if such infringement would have been avoided by the
     use of current or unaltered releases of the Software that MSI provides to
     Distributor, or (B) the combination, operation or use of the Software
     furnished under this Agreement with products or data not furnished by MSI
     if such infringement would have been avoided by the use of the Software
     without such products or data.

         (ii)  In the event the Software is held or is believed by MSI to
     infringe, MSI shall have the option, at its expense, to (A) modify the
     Software to be non-infringing, (B) obtain for the Company the right to
     continue using and distributing the Software, or (C) terminate this
     Agreement with respect to the infringing Software and refund the fees paid
     for such Software, to the extent each Customer, if any, requests a
     corresponding refund, but in any event the amount of the refund shall equal
     [*] multiplied by a fraction, the numerator of which shall be [*] and the
     denominator of which shall be [*].

         (iii) This Section 8(a) states the Company's exclusive remedy and
     MSI's entire liability for any infringement.

     (b) Other Indemnity. The Company shall be responsible and shall indemnify
         ---------------                                                      
and hold MSI harmless for any and all losses, liability or damages arising out
of or incurred in connection with (i) Company's, Subdistributors' or Customers'
marketing, distribution or use of the Software, except for valid warranty claims
under Section 7 above and valid third party infringement Claims under Section
8(a) above, and (ii) any unauthorized representation, warranty or agreement,
express or implied, made by Company, any Subdistributor or Customer to or with
any other Customers or any third party with respect to the Software.

* CONFIDENTIAL TREATMENT REQUESTED

                                       13
 
<PAGE>

9.   PROPRIETARY RIGHTS.

     (a) Ownership of Proprietary Rights. MSI shall retain all of its rights,
         -------------------------------                                     
title and interest in and to and ownership of all copyrights, trademarks, trade
secrets, patents, mask works and all other industrial and intellectual property
embodied in the Software including any improvements, updates, enhancements or
modifications to the Software. Except as otherwise expressly provided in this
Agreement, the Company has no right, title or interest in the Software or any
industrial or intellectual property relating to the Software and shall not copy,
reproduce, reverse engineer, decompile, disassemble, or otherwise use, in whole
or in part, the Software. The Company shall keep each and every item to which
MSI retains title free and clear of all claims, liens, and encumbrances except
those of MSI, and any act of the Company, voluntary or involuntary, purporting
to create a claim, lien, or encumbrance on such item shall be void.

     (b) No Modification. Except as required under Section 3(d) hereof, the
         ---------------                                                   
Company shall distribute the Software only in the form shipped by MSI, and the
Company shall not alter, modify, or change the Software or its package or use in
relation to any product or any trademark of the Company or any third parties
without the prior written consent of MSI.

     (c) Trademarks and Trade Names.
         -------------------------- 

         (i)   In connection with the distribution or advertising of the
     Software, the Company may use such trade names or Trademarks of MSI listed
     in Appendix E, as may be amended from time to time by MSI. The Company
     acknowledges the validity of such Trademarks and trade names and MSI's
     ownership thereof. All such marks and names and any additional marks of
     which MSI may in the future be the proprietor will bear the designation
     (TM) or the designation (R) as specified by MSI. The Company agrees to
     submit to MSI any published material not previously reviewed by MSI
     containing references to the Software for MSI's approval prior to the
     publication or release of such published material, such approval shall not
     be unreasonably withheld. The Company shall not challenge MSI's rights to
     use the Trademarks or trade names which MSI may apply to or use in
     connection with the Software. If the Company in the course of its business
     in the distribution of the Software acquires any goodwill or reputation in
     any of the Trademarks or trade names of MSI applied thereto, then at the
     expiration or termination of this Agreement all such goodwill or reputation
     automatically shall vest in MSI without any separate payment or other
     consideration of any kind to the Company, and the Company agrees to take
     all such actions necessary to effect such vesting.

         (ii)  The Company shall, at the request and expense of MSI, do such
     acts or things as MSI may reasonably require for the purpose of obtaining,
     maintaining, enforcing and preserving any of the Trademarks, trade names or
     other proprietary rights of MSI in the Territory; provided, however, that
     the Company agrees that only MSI has the right to enjoin any infringement
     or registration by a third party of the trademarks, trade names or similar
     rights.  In the event that any unlawful copying of the Software,
     infringement of MSI's rights in the Software, or infringement or
     registration by a third party of the trademarks, trade names or other
     property rights of MSI in the Territory comes to the

                                       14
 
<PAGE>

 
     attention of the Company, the Company shall immediately inform MSI in
     writing, stating the full facts of the infringement or registration known
     to it, including the identity of the suspected infringer or registrant, the
     place of the asserted infringement or registration and evidence thereof.
     The Company agrees to cooperate fully with MSI at the expense of MSI if MSI
     sues to enjoin such infringements or to oppose or invalidate any such
     registration.  Notwithstanding the foregoing, in the event that MSI refuses
     in writing to enjoin such infringements or to oppose or invalidate any such
     registration following a written request by the Company to do so, the
     Company may, at its expense, sue to enjoin or otherwise oppose any such
     infringement of MSI's proprietary rights.

         (iii) Except as permitted herein, the Company shall not (nor shall it
     attempt to) adopt, use, or register any acronym, Trademark, trade names or
     other marketing name of MSI or any confusingly similar work or symbol as
     part of the Company's own name or the name of any of its affiliates or the
     names of the products it markets.

     (d) Nondisclosure and Non-Use.
         ------------------------- 

         (i)   Without the prior written consent of the supplying party, no
     receiving party, its officers, directors, agents or employees shall, in the
     case of Confidential Information (as defined hereafter) of a business
     nature, both during the term of this Agreement and for a period of three
     (3) years after termination of this Agreement, and in the case of
     Confidential Information of a technical nature, both during the term of
     this Agreement and for period of ten (10) years after the termination of
     this Agreement, in any manner whatsoever disclose or communicate such
     information to a third party, except as legally required by a governmental
     or judicial agency, and each party agrees to keep such Confidential
     Information strictly confidential. For the purpose of this Agreement, the
     term "Confidential Information" shall mean and include any and all
     financial and other information relating to MSI's or the Company's business
     and their respective relationships with Teijin, the Software, the
     Documentation, information relating to the Software (including but not
     limited to technical information such as design specifications,
     instructions, and know-how) acquired either directly or indirectly by
     either party hereunder; provided, however, that all such Confidential
     Information shall be clearly marked as "confidential" and the term
     "Confidential Information" shall not include any information which:

               (1) has become or entered the public domain through no fault of
         the receiving party; or

               (2) was in the demonstrable possession of the receiving party
         prior to or at the time of receipt hereunder; or

               (3) was or has been obtained lawfully from a third party; or

                                       15
 
<PAGE>

               (4) has been independently developed by the receiving party
         without violation of its obligations under this Agreement, and which
         independent development is properly documented by such party.

         (ii)   Each party agrees, during the term of this Agreement, that it
     shall not use any Confidential Information obtained from the other for any
     purpose whatsoever except in a manner expressly provided for in this
     Agreement. The provisions of this Section 9(d) shall survive the
     termination of this Agreement.

10.  COMPLIANCE WITH LAWS.

     (a) Export Law Compliance. The Company understands and recognizes that the
         ---------------------                                                 
Software and other materials made available to it hereunder may be subject to
the export administration regulations of the United States Department of
Commerce and other United States government regulations related to the export of
technical data and equipment and products produced therefrom. The Company
represents that it is familiar with and agrees to comply with all such
regulations, including any future modifications thereof, in connection with the
distribution of the Software. The Company agrees that it will not export or re-
export outside the Territory, directly or indirectly, any Software or technical
data relating to the Software without the prior written consent of MSI and
without complying with all applicable regulations. The Company agrees to obtain
the same agreement from each of its Subdistributors and Customers. The Company
hereby agrees to indemnify and hold MSI harmless from any breach of this Section
10(a) by it, any Subdistributor and/or Customer.

     (b) Foreign Corrupt Practices Act. The Company hereby agrees to refrain 
         -----------------------------  
from making any payments to third parties which could cause MSI to violate the
U.S. Foreign Corrupt Practices Act. The Company hereby agrees to indemnify and
hold MSI harmless from any breach of this Section 10(b).

     (c) Licenses and Permits. The Company shall be responsible for obtaining at
         --------------------                                                   
its own expense, and shall use its best efforts to obtain, any and all required
non-U.S. governmental authorizations, including without limitation any import
licenses and foreign exchange permits. The Company shall provide proof of
compliance with required non-U.S. governmental authorization to MSI upon
request. MSI shall not be liable if any authorization is delayed, denied,
revoked, restricted or not renewed. The Company shall bear all such risks and
costs caused thereby. In addition, if this Agreement is terminated due to a
default of the Company, MSI or its designee shall be exclusively entitled, free-
of-charge, to any rights the Company may have acquired as a result of, or in,
governmental approvals, authorizations or permits. If this Agreement is
terminated due to a default of MSI, MSI shall pay the Company a reasonable sum
to be mutually agreed upon for the exclusive transfer to MSI or its designee of
any such rights the Company may have acquired as a result of, or in, said
governmental approvals, authorizations or permits. The Company agrees to use its
best efforts to effect the transfer of interest in the foregoing approvals,
authorizations or permits to MSI or to any third party so identified by MSI.

                                       16

<PAGE>

11.  EFFECTIVE DATE, TERM, TERMINATION AND EFFECT OF TERMINATION.

     (a) Effective Date. This Agreement shall become effective on March 1, 1998
         --------------                                                        
(the "Effective Date").

     (b) Term. This Agreement shall commence on the Effective Date and shall
         ----                                                               
remain in full force and effect until the dissolution of the Company pursuant to
the terms of the Joint Venture Agreement or unless the parties otherwise agree.

     (c) Termination by Either Party. Notwithstanding anything in this Agreement
         ---------------------------                                            
to the contrary, either party shall have the right, in addition and without
prejudice to any other rights or remedies, to terminate this Agreement
immediately upon written notice to the other party if the other party commits
any material breach of any of the terms of this Agreement which, in the case of
a breach capable of remedy, shall not have been remedied within thirty (30) days
of the receipt by the party in default of notice specifying the breach and
requiring its remedy.

     (d) Termination by MSI. MSI shall have the right, in addition and without
         ------------------                                                   
prejudice to any other rights or remedies, to terminate this Agreement:

         (i)   upon the termination of the Joint Venture Agreement for any
     reason, unless otherwise mutually agreed between MSI and Teijin where all
     the shares of the Company are acquired by either Teijin or MSI pursuant to
     Section 12 of the Joint Venture Agreement; or

         (ii)  upon written notice at any time for breach of Section 9 hereof
     (Proprietary Rights).

     (e) No Other Rights Upon Termination. It is expressly understood and agreed
         --------------------------------                                       
that the rights of termination as provided in this Agreement are absolute and
that both parties hereto have considered the making of expenditures in preparing
for performance as contemplated by this Agreement and possible losses and
damages incident and resulting to them that may result in the event of its
termination. Therefore, in agreeing to said terms of termination it is with the
full knowledge of such possibilities and except as provided herein neither party
hereto shall be responsible to the other for compensation, damages or otherwise
by reason of such termination of this Agreement at any time. Further, no
payments in the nature of severance payments shall be due either party upon
termination of this Agreement at any time. Without limiting the generality of
the foregoing, the Company understands and acknowledges that any contracts or
other arrangements it enters into with any third parties with respect to the
Software will be subject and subordinate to the rights of termination set forth
in this Agreement. The Company will indemnify and hold MSI harmless from any and
all liability, loss, damages, costs or expenses incurred by MSI in connection
with claims by any such third party made because of the termination of this
Agreement.

     (f) Effect of Termination. Termination or expiration of this Agreement
         ---------------------                                             
shall not affect any other rights of either party which may have accrued up to
the date of such termination or expiration and the Company shall not be relieved
of any obligation for any sums due to MSI for

                                      17
<PAGE>
 
the Software or services covered by purchase orders accepted prior to
termination or expiration or any confidentiality obligations of the Company
under Section 9(d) of this Agreement. Upon termination:

         (i)   the due date of all outstanding invoices to the Company for the
     Software shall automatically be accelerated to become due and payable by
     immediate wire transfer on the effective date of termination, even if
     longer terms have been previously agreed to;

         (ii)  all orders or portions thereof remaining unshipped as of the
     effective date of termination shall automatically be cancelled; and

         (iii) all executed User Agreements between Customers and the Company
     then in effect, and all rights and obligations thereunder, shall
     immediately be assigned by the Company to MSI or its designee.

     (g) The Company's Duties Upon Termination. Upon the termination or
         -------------------------------------                         
expiration of this Agreement, the Company agrees to do the following:

         (i)   refrain thereafter from representing itself as a distributor of
     MSI or using any trademarks or trade names of MSI;

         (ii)  immediately return to MSI or immediately destroy (A) all
     Confidential Information of MSI including but not limited to advertising
     matter and (B) all other printed material in its possession or under its
     control containing or bearing any trademark or trade names of MSI;

         (iii) take all appropriate steps to remove and cancel its listing in
     telephone books, directories, public records or elsewhere, which state or
     indicate that the Company is a distributor of MSI;

         (iv)  make available to MSI for a period of one (1) year for inspection
     and copying all books and records of the Company that pertain to the
     Company's performance of and compliance with its obligations, warranties
     and representations under this Agreement; and

         (v)   immediately cease using the applicable Software, and certify in
     writing to MSI within thirty (30) days after such termination that the
     Company has either destroyed, permanently erased or returned to MSI the
     Software, all related Documentation and all copies. This requirement
     applies to copies in all forms, partial and complete, in all types of media
     and computer memory and storage, and whether or not modified or merged into
     other programs or materials.

                                       18
<PAGE>
 
12.  GENERAL TERMS.

     (a) Assignment. Except in connection with the sale of all or substantially
         ----------                                                            
all of MSI's assets, or its business (by merger or otherwise), or any similar
transfer by MSI, any attempted assignment of the rights or delegation of the
obligations under this Agreement shall be void without the prior written consent
of the non-assigning or non-delegating party.

     (b) Benefits and Binding Nature of Agreement. In the case of any permitted
         ----------------------------------------                              
assignment or transfer of or under this Agreement, this Agreement or the
relevant provisions shall be binding upon, and inure to the benefit of, the
successors, executors, heirs, representatives, administrators and assigns of the
parties hereto.

     (c) Entire Agreement. This Agreement, together with the Appendices attached
         ----------------                                                       
hereto and incorporated herein by reference, embodies the final, complete and
exclusive understanding between the parties, and replaces and supersedes all
previous agreements, understandings or arrangements between the parties with
respect to its subject matter. No modification or waiver of any terms or
conditions hereof, nor any representations or warranties shall be of any force
or effect unless such modification or waiver is in writing and signed by an
authorized officer of each party hereto. It is expressly agreed that any of the
terms and conditions of the Company's purchase order or the like shall be
superseded by the terms and conditions of this Agreement.

     (d) Force Majeure. Neither party shall be liable to the other for its
         -------------                                                    
failure to perform any of its obligations under this Agreement, except for
payment obligations, during any period in which such performance is delayed
because rendered impracticable or impossible due to circumstances beyond its
reasonable control, including but not limited to fire, flood, earthquake,
explosion, acts of God, labor trouble or shortage, inability to obtain or
shortage of materials, equipment or transportation, insurrections, riots, war,
acts or requirements of the governments in any state, provided that the party
experiencing the delay promptly notifies the other of the delay. Any
installation, warranty, technical support, consulting services and other
services to be performed at the Company's facility may not be performed if MSI
reasonably believes conditions at such facility represent a safety or health
hazard to any MSI employee.

     (e) Notice. All notices concerning this Agreement shall be written in the
         ------                                                               
English language and shall be deemed to have been received (i) ten (10) days
after being properly airmailed, postage prepaid, (ii) three (3) business days
after being properly sent by commercial overnight courier, or (iii) two (2)
business days after being transmitted by confirmed telecopy, in each case
addressed to the relevant party at its address first set forth in this Agreement
to the attention of Michael J. Savage, President, in the case of MSI, and to the
attention of Nobuya Kawasaki in the case of the Company.

     (f) Governing Law and Official Language. This Agreement is made in
         -----------------------------------                           
accordance with and shall be governed and construed under the laws of the State
of California, U.S.A., as applied to agreements executed and performed entirely
in California by California residents and in no event shall this Agreement be
governed by the United Nations Convention on Contracts for the International
Sale of Goods; provided, however, that the provisions of this Agreement relating
to

                                       19
<PAGE>
 
dispute resolution, as set forth in Section 12(g) below, shall be governed
exclusively by the United States Arbitration Act (9 U.S.C. Section et. seq.)
notwithstanding any different or contrary provision of state law. The official
text of this Agreement and any Appendix or any notice given or accounts or
statements required by this Agreement shall be in English. In the event of any
dispute concerning the construction or meaning of this Agreement, reference
shall be made only to this Agreement as written in English and not to any other
translation into any other language.

     (g) Dispute Resolution. If a dispute arises between the parties arising out
         ------------------                                                     
of or in relation to this Agreement, the parties shall use all reasonable
efforts to resolve the dispute through good faith discussions. The senior
management of each of MSI and the Company commits itself to respond promptly to
any such dispute. In the event that MSI and the Company are unable, after
exerting all reasonable efforts, to resolve the said dispute, the said dispute
shall be finally settled through binding arbitration on the following basis:

         (i)   The arbitration shall be conducted by a panel of three (3)
     arbitrators under the International Arbitration Rules of the American
     Arbitration Association then in force, by which each of MSI and the Company
     agrees to be bound. Within thirty (30) days after notice of arbitration has
     been given, each of MSI and the Company shall appoint one (1) arbitrator.
     The arbitrators appointed by the parties shall then appoint a third
     arbitrator, who shall serve as the presiding arbitrator.

         (ii)  If demand for arbitration is made by the Company, the place of
     arbitration shall be San Diego, California, U.S.A, and if demand for
     arbitration is made by MSI, the place of arbitration shall be Tokyo, Japan.

         (iii) The language to be used in the arbitration shall be English.

         (iv)  Any arbitrator may be of any nationality, and need not be a
     lawyer or hold any other professional status or membership.

         (v)   The arbitral award shall be rendered in writing, shall state the
     reasons for the award, and shall be final and binding upon the parties. In
     no event shall the arbitral award include a sum for punitive damages.

         (vi)  Judgment upon any award may be entered by any court of competent
     jurisdiction, or application may be made to such a court for judicial
     acceptance of the award and any appropriate order including enforcement.

         (vii) Each of MSI and the Company shall bear its own expenses and
     attorneys' fees in connection with the arbitration.

     (h) Waiver. Any waiver (express or implied) by either party of any default
         ------                                                                
or breach of this Agreement shall not constitute a waiver of any other or
subsequent default or breach.

                                       20
<PAGE>
 
     (i) Severability. In the event that any provision of this Agreement shall
         ------------                                                         
be unenforceable or invalid under any applicable law or be so held by applicable
court decision, such unenforceability or invalidity shall not render this
Agreement unenforceable or invalid as a whole, and, in such event, such
provision shall be changed and interpreted so as to best accomplish the
objectives of such unenforceable or invalid provision within the limits of
applicable law or applicable court decisions.

     (j) Rights and Remedies Cumulative. Except as expressly provided herein,
         ------------------------------                                      
the rights and remedies provided in this Agreement shall be cumulative and not
exclusive of any other rights and remedies provided by law or otherwise.

     (k) No Agency - Independent Contractors. The Company shall act as an
         -----------------------------------                             
independent contractor under the terms of this Agreement. The Company is not,
and shall not be deemed to be, an employee, agent, partner or legal
representative of MSI for any purpose. The Company shall not be entitled to
enter into any contracts in the name of, or on behalf of MSI, nor shall the
Company be entitled to pledge the credit of MSI in any way or hold itself out as
having authority to do so.

     (l) Captions and Section References. The section headings appearing in this
         -------------------------------                                        
Agreement are inserted only as a matter of convenience and in no way define,
limit, construe or describe the scope or extent of such section or in any way
affect such section.

     (m) Counterparts. This Agreement may be executed in counterparts with the
         ------------                                                         
same force and effect as if each of the signatories had executed the same
instrument.

     (n) No Limitation on Supplier MSI. Nothing in this Agreement shall be
         -----------------------------                                    
construed so as to preclude MSI from selling or otherwise marketing any of the
Software to (i) any Customer outside the Territory, (ii) any value added
reseller or original equipment manufacturers outside the Territory, or (iii) any
other distributors outside the Territory.

     (o) Parties Advised by Counsel -- No Interpretation Against Drafter. This
         ---------------------------------------------------------------      
Agreement has been negotiated between unrelated parties who are sophisticated
and knowledgeable in the matters contained in this Agreement and who have acted
in their own self interest. In addition, each party has been represented by
legal counsel. Accordingly, any rule of law, including Section 1654 of the
California Civil Code, as well as any other statute, law, ordinance, or common
law principles or other authority of any jurisdiction of similar effect, or
legal decision that would require interpretation of any ambiguities in this
Agreement against the party who has drafted it is not applicable and is hereby
waived. The provisions of this Agreement shall be interpreted in a reasonable
manner to effect the purpose of the parties, and this Agreement shall not be
interpreted or construed against any party to this Agreement because that party
or any attorney or representative for that party drafted this Agreement or
participated in the drafting of this Agreement.

     (p) Authority to Enter Into and Execute Agreement. Both parties represent
         ---------------------------------------------                        
and warrant to each other that they have the right and lawful authority to enter
into this Agreement 

                                       21
<PAGE>
 
for the purposes herein and that there are no other outstanding agreements or
obligations inconsistent with the terms and provisions hereof.

     IN WITNESS WHEREOF, the parties hereto have each caused this Agreement to
be signed and delivered by their duly authorized representatives as of the date
first set forth herein.

MOLECULAR SIMULATIONS INCORPORATED



By:    /s/Michael J. Savage
       -----------------------------
       Michael J. Savage,
       President


TEIJIN MOLECULAR SIMULATIONS INCORPORATED



By:    /s/Nobuya Kawasaki
       -----------------------------
Name:  Nobuya Kawasaki
Title: President & CEO



                                  Appendix A

                      SOFTWARE, CONSORTIA AND PRICE LISTS

                                      [*]


* CONFIDENTIAL TREATMENT REQUESTED

                                       
<PAGE>
 
                                  APPENDIX B

                   STANDARD USER AGREEMENT FOR MSI SOFTWARE


<PAGE>
 
Agreement No:_________________               Effective Date:_________________

 

                      MOLECULAR SIMULATIONS INCORPORATED
                                USER AGREEMENT
                                        
This user agreement ("Agreement") shall be effective on the date written above
and is between MOLECULAR SIMULATIONS INCORPORATED ("MSI"), 9685 Scranton Road,
San Diego, CA  92121 and
___________________________________________________________________("Customer"),
located at _______________________________________________________________.

     Under this Agreement, (a) MSI will provide and Customer will accept a right
to use the object code version of MSI's proprietary software product(s) set
forth on Attachment A to this Agreement, and/or (b) MSI will sell Customer
certain computer equipment described in Attachment A, in each case on the terms
and conditions specified below. MSI's software product(s), together with related
documentation and components (including new releases, enhancements, and
modifications provided under warranty or maintenance, if applicable), shall be
referred to and defined as "Software." The computer equipment sold under this
Agreement, together with any operating system software installed on it, is
referred to as "Equipment."

                                        
1. TERM; PAYMENT                       
     1.1 The right to use granted hereunder is effective upon execution of this
Agreement by Customer and MSI. The term of the right to use is perpetual unless
otherwise specified in Attachment A. The right to use shall remain in effect
for such term unless terminated by either party as set forth in Section 8.
     1.2 Customer shall pay MSI the amount set forth in Attachment A within
thirty (30) days of invoice. The charges under this Agreement are exclusive of
local, state, or federal use, excise, personal property, sales or other similar
taxes or duties which may be imposed as a result of the transactions under this
Agreement. Customer shall be responsible for all such taxes and duties, except
for taxes on MSI's net income.

2. RIGHT TO USE SOFTWARE                
     2.1 MSI hereby grants and Customer accepts a nontransferable and non-
exclusive right to use the Software only to process the work of Customer's own
business. Customer may not use the Software to process the work of any other
party and may only use the Software at the specific location to which the
Software is delivered. For host-locked rights to use, Customer may use the
Software only on the central processing unit (the "Original CPU") originally
designated for installation, and only at the specific location to which the
Software is delivered. For floating rights to use, the Software may be accessed
by any computer that is commercially supported by MSI and within Customer's
authorized network at the specific location to which the Software is delivered,
but may not be accessed from remote sites. The Software may be used by no more
than that number of simultaneous users for which the right to use is granted,
and may not be electronically or otherwise transferred to a different physical
location. If Customer desires to use the Software for additional simultaneous
users, at another site, or on a different CPU (for host-locked right to uses),
Customer shall secure MSI's prior approval, which may be granted subject to
additional charges.
     2.2 No title or ownership rights to the Software are transferred to
Customer by this Agreement, but shall remain with MSI and/or its licensors.
 
3. SOFTWARE MAINTENANCE
     3.1 For a period of one (1) year from delivery of the Software, MSI will
provide, without charge, the services set forth in this Section 3. Thereafter,
maintenance will be provided for twelve month periods until terminated by either
party upon thirty (30) days written notice prior to the renewal date. Annual
maintenance fees are payable in advance on the anniversary date of the order.
Additional charges apply to initiate maintenance for Software that has not been
under continuous maintenance since installation.
     3.2 Maintenance includes new releases, corrections, enhancements, and
improvements to the Software and related documentation. Maintenance also
includes reasonable assistance and consultation to assist Customer in resolving
problems with the use of the Software, including the verification, diagnosis,
and correction of material errors and defects in the Software. Maintenance does
not include new products sold separately by MSI.
     3.3 Maintenance will be provided for the current release of the Software on
computer platforms that MSI commercially supports; prior releases shall be
maintained for twelve months following a new release.
                                      
4. EQUIPMENT                         
     4.1 The Equipment is manufactured by third party equipment suppliers.
Delivery is F.O.B. MSI's equipment suppliers' shipment points. Title and all
risk of damage or loss to Equipment shall pass to Customer upon delivery to
carrier at MSI's equipment suppliers' shipment points. MSI retains a purchase
money security interest in Equipment delivered hereunder and in any proceeds
Customer receives from resale or lease thereof, until payment of the purchase
price to MSI. Customer agrees to execute financing statements as MSI may request
to protect its security interest. All Equipment manufacturers' software included
with the Equipment is right to used to Customer solely in accordance with such
manufacturers' standard right to use terms included with the Equipment.
                                      
5. WARRANTY AND LIMITATION OF LIABILITY                             
     5.1 MSI warrants that it has the right to distribute the Software according
to the terms of this Agreement. MSI further warrants that, for the twelve (12)
months following delivery (the "Warranty Period"), the Software will perform
substantially in accordance with the MSI-supplied User Manual when properly


<PAGE>
 
operated on the designated hardware and operating system. MSI does not warrant
that operation of the Software will be error free.
     5.2 MSI's sole obligation during the Warranty Period is to replace
defective Software media or materials and to use reasonable efforts to correct
any material error or defect in the Software as expeditiously as reasonably
possible. This warranty does not apply to problems arising from (i) Customer's
modification or misuse of the Software; (ii) malfunction of Customer's
equipment, operating system, or software not supplied by MSI; or (iii) attempts
to use the Software in a manner or purpose for which it was not intended.
     5.3 With respect to Equipment purchased under this Agreement, any
warranties provided by the Equipment manufacturers (including all applicable
limitations thereto) are passed through to Customer if and to the extent
permitted by such warranties.
     5.4 MSI MAKES NO OTHER WARRANTIES, EXPRESS OR IMPLIED, REGARDING THE
SOFTWARE OR EQUIPMENT, AND DISCLAIMS ALL IMPLIED WARRANTIES OF MERCHANTABILITY
AND FITNESS FOR A PARTICULAR PURPOSE. MSI's LIABILITY FOR ANY LOSSES OR DAMAGES
THAT ARISE OUT OF THE PERFORMANCE OR BREACH OF THIS AGREEMENT (EXCEPT AS STATED
IN SECTION 7), WHETHER IN CONTRACT, TORT, OR OTHER FORM OF ACTION, SHALL NOT
EXCEED THE TOTAL PRICE PAID TO MSI UNDER THIS AGREEMENT. IN NO EVENT SHALL MSI
OR ITS SUPPLIERS BE LIABLE FOR ANY SPECIAL, INCIDENTAL, OR CONSEQUENTIAL
DAMAGES, INCLUDING, BUT NOT LIMITED TO, LOST PROFITS, LOSS OF GOODWILL, DATA
LOSS, BUSINESS DISRUPTION, OR COMPUTER FAILURE.
                                                                               
6. NON-DISCLOSURE; ALTERATIONS; COPIES                                         
     6.1 The Software is the valuable and proprietary trade secret of MSI.
Customer shall (i) maintain the confidentiality of the Software, using, at a
minimum, the same safeguards afforded its own confidential, proprietary trade
secrets; (ii) limit access to the Software to its employees and its consultants
who have confidentiality obligations to Customer; (iii) not disclose, provide,
transfer, rent, distribute, or otherwise make available any portion of the
Software to another party. Customer's non-disclosure obligation shall not apply
to information now or hereafter in the public domain through no fault of
Customer, information in the possession of Customer prior to disclosure by MSI,
information properly obtained without restriction from a third party who is not
bound by an obligation of confidentiality to MSI, or information independently
developed by Customer without reference to the Software.
     6.2 Customer shall not alter, modify, adapt, translate, reverse engineer,
decompile, disassemble, or create derivative works from the Software, nor take
any other steps intended to produce a source language statement of the Software
or any part thereof without MSI's express prior written consent.
     6.3 Customer is authorized to copy the Software solely for backup,
archival, and disaster recovery purposes. Customer agrees not to remove any
copyright or proprietary rights notices from the Software and to reproduce all
such notices on any copies that it makes. Customer is prohibited from copying,
in whole or in part, any Software documentation or training materials;
additional documentation is available for a separate fee.
     6.4 The obligations of this Section 6 shall survive termination of this   
Agreement or any right to use granted hereunder.                                
                                                                                
7. INFRINGEMENT INDEMNIFICATION                                                
     7.1 MSI shall at its expense defend Customer against any claim, and shall
indemnify and hold Customer harmless from any final judgment, that a current,
unmodified copy of the Software infringes a U.S. patent or copyright, provided
that (i) MSI is given prompt written notice of any such claim, (ii) MSI shall
have sole control of the settlement or defense of any action against Customer to
which this indemnity applies; and (iii) Customer cooperates with MSI, at MSI's
expense, in every reasonable way to facilitate such defense.
     7.2 Should the use of the Software be enjoined, or should MSI desire to
minimize its liabilities hereunder, MSI shall have the right, at its sole option
and expense, to secure the right for Customer to continue use of the Software
or to replace or modify the Software to make it noninfringing. If such remedies
are not reasonably available, Customer shall be entitled to a pro rata refund
of the price paid for such Software based on a five year amortization. The
foregoing sets forth the entire liability of MSI and Customer's exclusive
remedy with respect to claims of infringement arising from Customer's use of the
Software.
                                                    
8. TERMINATION                                     
     8.1 If either party breaches a material provision of this Agreement, the
other party may give written notice of default. If the breaching party fails to
cure the breach within thirty (30) days, this Agreement may be terminated
immediately by the other party. In the event that Customer has made an
unauthorized disclosure or distribution of the Software or other MSI
confidential information, this Agreement shall terminate upon written notice by
MSI.                                                    
     8.2 Upon termination, Customer shall make no further use of the Software
and shall either return to MSI or destroy originals and all copies of the
Software and supporting materials. Customer shall supply an affidavit to MSI
certifying that it no longer possesses any embodiments of the Software. No
refunds or credits will be due.
                                                    
9. GENERAL                                         
     9.1 Neither party may assign or transfer its rights, liabilities or
obligations under this Agreement without the prior written consent of the other,
except by operation of law in the case of merger, acquisition, or
consolidation.
     9.2 All notices required hereunder shall be in writing and sent by
certified mail, express mail, or other overnight courier to the addresses
written above, or such other address as noticed to the parties.
     9.3 This Agreement and any Attachments and Addenda constitute the entire
agreement between the parties with respect to the subject matter hereof
(Attachment A and any future Attachment A signed by MSI and Customer are
expressly incorporated by reference into this Agreement). There are no
representations, promises, warranties, or understandings relied upon by
Customer that are not contained herein. This Agreement may be modified only in
writing signed by both parties. Terms and conditions on any Customer purchase
order or other ordering document shall not be deemed to modify this Agreement.
Additional purchases of rights to


<PAGE>
 
use the Software or of Equipment by Customer without execution of another
agreement will be governed by the terms of this Agreement unless the parties
otherwise agree in writing. The failure by either party to insist upon strict
enforcement of any terms and conditions of this Agreement shall not be
construed as a waiver of the right to assert or rely upon any such terms on any
future occasion.                                                    
     9.4 This Agreement shall be governed by and interpreted under the
substantive laws of the State of California. If any provision of this Agreement
is held to be unenforceable, such decision shall not affect the validity or
enforceability of any or all of the remaining provisions.
     9.5 Customer agrees not to export any product supplied by MSI or any part
or direct product thereof in violation of U.S. Export Administration
regulations. In furtherance of these obligations, Customer hereby represents,
warrants and covenants that it will not use, or authorize or permit any other
person, firm, corporation or other entity to use, the Software, or make the
Software available for use, in connection with the design, development,
production, stockpiling or use of any chemical or biological weapons.
     9.6 If the Software is used by Customer to obtain results that are
published in a scientific journal or other publication, Customer will
acknowledge its use of the Software with an appropriate citation, which shall
include MSI's full corporate name and the name of the Software product used.
     9.7 All Software supplied by MSI to the government is provided with
restricted rights as set forth in the legends accompanying the Software.

IN WITNESS WHEREOF, THIS AGREEMENT HAS BEEN SIGNED BY DULY AUTHORIZED
REPRESENTATIVES OF CUSTOMER AND MSI.


CUSTOMER:
          ------------------------------------------

BY:
    ------------------------------------------------

NAME:
      ----------------------------------------------

TITLE:
       ---------------------------------------------

DATE:
      ----------------------------------------------

MOLECULAR SIMULATIONS INCORPORATED


BY:
    ------------------------------------------------

NAME:
      ----------------------------------------------

TITLE:
       ---------------------------------------------

DATE:
      ----------------------------------------------


PLEASE SIGN AND RETURN ALL COPIES; CUSTOMER COPY WILL BE RETURNED AFTER
SIGNATURE BY MSI.


<PAGE>
 
                                  APPENDIX C

                       WIRE TRANSFER (BANK) INFORMATION



Yen payments to be remitted as follows:


Bank                                     [*]
Branch:                                  [*]
Account Name:                            [*]
Account Number:                          [*]
Beneficiary Inst.:                       For the further benefit of MSI

Dollar payments to be remitted as follows:

Bank:                                    [*]
Branch:                                  [*]
Account Name:                            [*]
Account Number:                          [*]
Beneficiary Inst.:                       For the further benefit of MSI


* CONFIDENTIAL TREATMENT REQUESTED.


<PAGE>
 
                                  APPENDIX D

                                MSI TRADEMARKS

          The Company has the following trademarks:

1. WebLab
2. Cerius and Cerius2
3. Insight and Insight II
4. CHARMm
5. Catalyst
6. Quanta
7. Discover
8. Biosym
9. X-PLOR

WebLab is a trademark for which registration applications have been filed in the
in U.S., Canada, Europe and Japan.  Cerius, Insight, CHARMm, Catalyst, Discover
and Biosym are trademarks that have been registered in the U.S.  Quanta is a
trademark that had been registered in the U.S., but is now a common law
trademark.  X-PLOR is a registered trademark of Harvard that is licensed to the
Company.


<PAGE>
 
                                  APPENDIX E

             LIST OF WEBLAB PRODUCTS AVAILABE FROM MSI'S WEB PAGE


1. WebLab ViewerPro.