----

**UNITED STATESSECURITIES AND EXCHANGE COMMISSION****Washington, DC 20549**

----

**FORM 10-Q**

----

**(Mark One)**

| **|X|  QUARTERLY REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE**                                                                                                                                                                                                                    |
|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| **SECURITIES EXCHANGE ACT OF 1934**                                                                                                                                                                                                                                                      |
| **For the quarterly period ended June 30, 2002**                                                                                                                                                                                                                                         |
| **OR**                                                                                                                                                                                                                                                                                   |
| **|_|  TRANSITION REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE**                                                                                                                                                                                                                   |
| **SECURITIES EXCHANGE ACT OF 1934**                                                                                                                                                                                                                                                      |
| **For the transition period from                      to                     .** |
|                                                                                                                                                                                                                                                                                          |
| **Commission file number 0-28494**                                                                                                                                                                                                                                                       |
| **MILLENNIUM PHARMACEUTICALS, INC.**                                                                                                                                                                                                                                                     |
| (Exact name of registrant as specified in its charter)                                                                                                                                                                                                                                   |

| **Delaware**                                                  |   | **04-3177038**                                |
|---------------------------------------------------------------|--------|-----------------------------------------------|
| (State or other jurisdictionof incorporation or organization) |   | (I.R.S. EmployerIdentification No.) |

**75 Sidney Street, Cambridge, Massachusetts 02139**(Address of principal executive offices) (zip code)

**(617)  679-7000**(Registrant's telephone number, including area code)

----

Indicate by check mark whether the registrant (1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past 90 days. Yes |X| No |_|

The total number of shares of the registrant's Common Stock, $0.001 par value, outstanding on August 9, 2002, was 284,432,421.

----

**MILLENNIUM PHARMACEUTICALS, INC.**

**FORM 10-Q**

**FOR THE QUARTER ENDED JUNE 30, 2002**

**TABLE OF CONTENTS**

|             |                                                                                                     | Page                       |   |
|------------------|----------------------------------------------------------------------------------------------------------|----------------------------|--------|
|             |                                                                                                     |                            |   |
| **PART I**  | **FINANCIAL INFORMATION**                                                                                |                       |   |
|             |                                                                                                     |                       |   |
| Item 1.          | Condensed Consolidated Financial Statements                                                              |                       |   |
|             |                                                                                                     |                       |   |
|             | Condensed Consolidated Balance Sheets as ofJune 30, 2002 and December 31, 2001                           | 3      |   |
|             |                                                                                                     |                       |   |
|             | Condensed Consolidated Statements of Operations for thethree and six months ended June 30, 2002 and 2001 | 4      |   |
|             |                                                                                                     |                       |   |
|             | Condensed Consolidated Statements of Cash Flows for thesix months ended June 30, 2002 and 2001           | 5      |   |
|             |                                                                                                     |                       |   |
|             | Notes to Condensed Consolidated Financial Statements                                                     | 6      |   |
|             |                                                                                                     |                       |   |
| Item 2.          | Management's Discussion and Analysis of FinancialCondition and Results of Operations                     | 13     |   |
|             |                                                                                                     |                       |   |
|             | Certifications of Officers                                                                               | 22     |   |
|             |                                                                                                     |                       |   |
|             | Risk Factors That May Affect Results                                                                     | 22     |   |
|             |                                                                                                     |                       |   |
| Item 3.          | Quantitative and Qualitative Disclosures about Market Risk                                               | 32     |   |
|             |                                                                                                     |                       |   |
| **PART II** | **OTHER INFORMATION**                                                                                    |                       |   |
|             |                                                                                                     |                       |   |
| Item 2.          | Changes in Securities and Use of Proceeds                                                                | 33     |   |
|             |                                                                                                     |                       |   |
| Item 4.          | Submission of Matters to a Vote of Security Holders                                                      | 33     |   |
|             |                                                                                                     |                       |   |
| Item 6.          | Exhibits and Reports on Form 8-K                                                                         | 33     |   |
|             |                                                                                                     |                       |   |
|             | Signatures                                                                                               | 34     |   |
|             |                                                                                                     |                       |   |
|             | Exhibit Index                                                                                            | 35     |   |
|             |                                                                                                     |                       |   |

*The following trademarks of the Company are used in this Quarterly Report on Form 10-Q:*  DiagnomicsTM, Melastatin®, Millennium®,Millennium PharmaceuticalsTM,  VELCADETM (bortezomib) for Injection and INTEGRILIN® (eptifibatide) Injection. CAMPATH® is a registeredtrademark of ILEX Pharmaceuticals, L.P., TNKaseTM and Activase® are trademarks of Genentech, Inc., ReoPro® is a trademark of Eli Lillyand Company and Aggrastat® is a trademark of Merck & Co., Inc. *Other trademarks used in this Quarterly Report on Form 10-Q are theproperty of their respective owners.*

2

----

**PART I     FINANCIAL INFORMATION**

**Item 1.    Condensed Consolidated Financial Statements**

**Millennium Pharmaceuticals, Inc.Condensed Consolidated Balance Sheets**

|                                                                                                                                                    | June 30, 2002 |   | December 31, 2001 |       |
|---------------------------------------------------------------------------------------------------------------------------------------------------------|---------------|--------|-------------------|------------|
||
||
||
| Current assets:                                                                                                                                         |          |   |              |       |   |   |   |   |
| Cash and cash equivalents                                                                                                                               |          |   | $                 | 54,841     |   | $ | 35,993 |   |
| Marketable securities                                                                                                                                   |          |   |              | 1,854,053  |   |   | 1,438,875 |   |
| Due from strategic alliance partners                                                                                                                    |          |   |              | 45,115     |   |   | 18,360 |   |
| Inventory                                                                                                                                               |          |   |              | 103,524    |   |   | — |   |
| Prepaid expenses and other current assets                                                                                                               |          |   |              | 60,358     |   |   | 21,389 |   |
|                                                                                                                                                    |          |   |                   |            |   |  |  |   |
| Total current assets                                                                                                                                    |          |   |              | 2,117,891  |   |   | 1,514,617 |   |
| Property and equipment, net                                                                                                                             |          |   |              | 246,112    |   |   | 168,600 |   |
| Restricted cash                                                                                                                                         |          |   |              | 38,942     |   |   | 47,308 |   |
| Other assets                                                                                                                                            |          |   |              | 37,407     |   |   | 13,362 |   |
| Goodwill, net                                                                                                                                           |          |   |              | 1,202,314  |   |   | 138,519 |   |
| Intangible assets, net                                                                                                                                  |          |   |              | 503,426    |   |   | 25,328 |   |
|                                                                                                                                                    |          |   |                   |            |   |  |  |   |
| Total assets                                                                                                                                            |          |   | $                 | 4,146,092  |   | $ | 1,907,734 |   |
|                                                                                                                                                    |          |   |                   |            |   |  |  |   |
|                                                                                                                                                    |          |   |              |       |   |   |   |   |
| **Liabilities and Stockholders' Equity**                                                                                                                |          |   |              |       |   |   |   |   |
| Current liabilities:                                                                                                                                    |          |   |              |       |   |   |   |   |
| Accounts payable                                                                                                                                        |          |   | $                 | 24,714     |   | $ | 25,237 |   |
| Accrued expenses                                                                                                                                        |          |   |              | 202,754    |   |   | 89,372 |   |
| Current portion of deferred revenue                                                                                                                     |          |   |              | 152,505    |   |   | 71,018 |   |
| Current portion of capital lease obligations                                                                                                            |          |   |              | 17,491     |   |   | 17,536 |   |
|                                                                                                                                                    |          |   |                   |            |   |  |  |   |
| Total current liabilities                                                                                                                               |          |   |              | 397,464    |   |   | 203,163 |   |
| Deferred revenue, net of current portion                                                                                                                |          |   |              | 9,207      |   |   | 17,902 |   |
| Capital lease obligations, net of current portion                                                                                                       |          |   |              | 29,927     |   |   | 35,107 |   |
| Long term debt                                                                                                                                          |          |   |              | 683,285    |   |   | 83,325 |   |
|                                                                                                                                                    |          |   |              |       |
| Commitments and contingencies                                                                                                                           |          |   |              |       |   |   |   |   |
|                                                                                                                                                    |          |   |              |       |
| Stockholders' equity:                                                                                                                                   |          |   |              |       |   |   |   |   |
| Preferred Stock, $0.001 par value; 5,000 shares authorized,none issued                                                                                  |          |   |              | —     |   |   | — |   |
| Common Stock, $0.001 par value; 500,000 shares authorized:284,063 shares at June 30, 2002 and 224,290 shares atDecember 31, 2001 issued and outstanding |          |   |              | 284        |   |   | 224 |   |
| Additional paid-in capital                                                                                                                              |          |   |              | 4,365,649  |   |   | 2,477,334 |   |
| Deferred compensation                                                                                                                                   |          |   |              | (3,277     | ) |   | (765 | ) |
| Notes receivable from officers                                                                                                                          |          |   |              | (170       | ) |   | (315 | ) |
| Accumulated other comprehensive income                                                                                                                  |          |   |              | 17,935     |   |   | 34,371 |   |
| Accumulated deficit                                                                                                                                     |          |   |              | (1,354,212 | ) |   | (942,612 | ) |
|                                                                                                                                                    |          |   |                   |            |   |  |  |   |
| Total stockholders' equity                                                                                                                              |          |   |              | 3,026,209  |   |   | 1,568,237 |   |
|                                                                                                                                                    |          |   |                   |            |   |  |  |   |
| Total liabilities and stockholders' equity                                                                                                              |          |   | $                 | 4,146,092  |   | $ | 1,907,734 |   |
|                                                                                                                                                    |          |   |                   |            |   |  |  |   |

See notes to condensed consolidated financial statements.

3

----

**Millennium Pharmaceuticals, Inc.Condensed Consolidated Statements of Operations(unaudited)**

|                                                                     | Three Months Ended June 30, |   | Six Months Ended June 30, |     |
|--------------------------------------------------------------------------|----------------------------------|--------|--------------------------------|----------|
||
||
|                                                                     |                             |   |                           |     |   |   |   |   |   |   |   |   |   |   |   |   |
| Revenues:                                                                |                             |   |                           |     |   |   |   |   |   |   |   |   |   |   |   |   |
|     Product revenue                                  |                             |   | $                              | 44,927   |   | $ | — |   |   |   | $ | 67,069 |   | $ | — |   |
|     Revenue under strategic alliances                |                             |   |                           | 46,927   |   |   | 59,066 |   |   |   |   | 93,384 |   |   | 109,430 |   |
|                                                                     |                             |   |                                |          |   |  |  |   |   |   |  |  |   |  |  |   |
|         Total revenues           |                             |   |                           | 91,854   |   |   | 59,066 |   |   |   |   | 160,453 |   |   | 109,430 |   |
|                                                                     |                             |   |                                |          |   |  |  |   |   |   |  |  |   |  |  |   |
| Costs and expenses:                                                      |                             |   |                           |     |   |   |   |   |   |   |   |   |   |   |   |   |
|     Research and development                         |                             |   |                           | 122,430  |   |   | 94,583 |   |   |   |   | 223,742 |   |   | 187,104 |   |
|     Selling, general and administrative              |                             |   |                           | 40,059   |   |   | 19,397 |   |   |   |   | 77,300 |   |   | 35,633 |   |
|     Cost of product revenue                          |                             |   |                           | 17,794   |   |   | — |   |   |   |   | 25,522 |   |   | — |   |
|     Acquired in-process research and development     |                             |   |                           | —   |   |   | — |   |   |   |   | 242,000 |   |   | — |   |
|     Amortization of intangibles                      |                             |   |                           | 9,754    |   |   | 16,029 |   |   |   |   | 15,297 |   |   | 32,296 |   |
|                                                                     |                             |   |                                |          |   |  |  |   |   |   |  |  |   |  |  |   |
|         Total costs and expenses |                             |   |                           | 190,037  |   |   | 130,009 |   |   |   |   | 583,861 |   |   | 255,033 |   |
|                                                                     |                             |   |                                |          |   |  |  |   |   |   |  |  |   |  |  |   |
| Loss from operations                                                     |                             |   |                           | (98,183  | ) |   | (70,943 | ) |   |   |   | (423,408 | ) |   | (145,603 | ) |
|                                                                     |                             |   |                           |     |   |   |   |   |   |   |   |   |   |   |   |   |
| Other income (expense):                                                  |                             |   |                           |     |   |   |   |   |   |   |   |   |   |   |   |   |
|     Investment income                                |                             |   |                           | 29,605   |   |   | 27,071 |   |   |   |   | 60,112 |   |   | 54,541 |   |
|     Realized loss on marketable securities           |                             |   |                           | (14,712  | ) |   | (580 | ) |   |   |   | (17,062 | ) |   | (591 | ) |
|     Interest expense                                 |                             |   |                           | (10,449  | ) |   | (2,317 | ) |   |   |   | (17,242 | ) |   | (4,653 | ) |
|     Gain on sale of equity interest in joint venture |                             |   |                           | 40,000   |   |   | — |   |   |   |   | 40,000 |   |   | — |   |
|     Equity in operations of joint venture            |                             |   |                           | —   |   |   | 39 |   |   |   |   | — |   |   | (925 | ) |
|     Debt financing charge                            |                             |   |                           | (54,000  | ) |   | — |   |   |   |   | (54,000 | ) |   | — |   |
|     Debt conversion expenses                         |                             |   |                           | —   |   |   | — |   |   |   |   | — |   |   | (2,567 | ) |
|                                                                     |                             |   |                                |          |   |  |  |   |   |   |  |  |   |  |  |   |
| Net loss                                                                 |                             |   | $                              | (107,739 | ) | $ | (46,730 | ) |   |   | $ | (411,600 | ) | $ | (99,798 | ) |
|                                                                     |                             |   |                                |          |   |  |  |   |   |   |  |  |   |  |  |   |
| *Amounts per common share:*                                              |                             |   |                           |     |   |   |   |   |   |   |   |   |   |   |   |   |
| Net loss per share, basic and diluted                                    |                             |   | $                              | (0.38    | ) | $ | (0.21 | ) |   |   | $ | (1.53 | ) | $ | (0.46 | ) |
|                                                                     |                             |   |                                |          |   |  |  |   |   |   |  |  |   |  |  |   |
| Weighted average shares, basic and diluted                               |                             |   |                           | 282,693  |   |   | 217,779 |   |   |   |   | 268,382 |   |   | 216,582 |   |
|                                                                     |                             |   |                                |          |   |  |  |   |   |   |  |  |   |  |  |   |

See notes to condensed consolidated financial statements.

4

----

**Millennium Pharmaceuticals, Inc.Condensed Consolidated Statements of Cash Flows(unaudited)**

|                                                                       | Six Months Ended June 30, |   |
|----------------------------------------------------------------------------|--------------------------------|--------|
||
||
|                                                                       |                           |   |   |   |   |   |   |   |
| **Cash Flows from Operating activities:**                                  |                           |   |   |   |   |   |   |   |
| Net loss                                                                   |                           |   | $ | (411,600 | ) | $ | (99,798 | ) |
| Adjustments to reconcile net loss to cash                                  |                           |   |   |   |   |   |   |   |
| used in operating activities:                                              |                           |   |   |   |   |   |   |   |
| Acquired in-process research and development                               |                           |   |   | 242,000 |   |   | — |   |
| Depreciation and amortization                                              |                           |   |   | 38,173 |   |   | 48,792 |   |
| (Gain) loss on available-for-sale securities, net                          |                           |   |   | 5,061 |  |   | (4,438 | ) |
| Stock compensation expense                                                 |                           |   |   | 4,852 |   |   | 1,991 |   |
| Equity in operations of joint venture                                      |                           |   |   | — |   |   | 925 |   |
| Changes in operating assets and liabilities:                               |                           |   |   |   |   |   |   |   |
|   Due from strategic alliance partners                           |                           |   |   | (13,370 | ) |   | (527 | ) |
|   Prepaid expenses and other current assets                      |                           |   |   | (33,112 | ) |   | (1,866 | ) |
|   Restricted cash and other assets                               |                           |   |   | (5,715 | ) |   | (582 | ) |
|   Accounts payable and accrued expenses                          |                           |   |   | 25,924 |   |   | 6,143 |   |
|   Deferred revenue                                               |                           |   |   | (25,555 | ) |   | (18,860 | ) |
|                                                                       |                           |   |  |  |   |  |  |   |
| Net cash used in operating activities                                      |                           |   |   | (173,342 | ) |   | (68,220 | ) |
|                                                                       |                           |   |  |  |   |  |  |   |
|                                                                       |                           |   |   |   |   |   |   |   |
| **Cash Flows from Investing activities:**                                  |                           |   |   |   |   |   |   |   |
| Investments in marketable securities                                       |                           |   |   | (690,685 | ) |   | (384,869 | ) |
| Proceeds from sales and maturities of marketable securities                |                           |   |   | 583,856 |   |   | 329,184 |   |
| Investment in joint venture                                                |                           |   |   | (505 | ) |   | (4,845 | ) |
| Purchase of property and equipment and other long term assets              |                           |   |   | (66,581 | ) |   | (21,961 | ) |
| Net cash acquired in COR Therapeutics, Inc. acquisition                    |                           |   |   | 309,147 |   |   | — |   |
|                                                                       |                           |   |  |  |   |  |  |   |
| Net cash provided by (used in) investing activities                        |                           |   |   | 135,232 |   |   | (82,491 | ) |
|                                                                       |                           |   |  |  |   |  |  |   |
|                                                                       |                           |   |   |   |   |   |   |   |
| **Cash Flows from Financing activities:**                                  |                           |   |   |   |   |   |   |   |
| Proceeds from sales of common stock                                        |                           |   |   | 53,405 |   |   | 100,000 |   |
| Net proceeds from employee stock purchases                                 |                           |   |   | 10,875 |   |   | 11,564 |   |
| Repayment of principal of long-term debt obligations                       |                           |   |   | (40 | ) |   | — |   |
| Repayment of notes receivable from officers                                |                           |   |   | 130 |   |   | — |   |
| Principal payments on capital leases                                       |                           |   |   | (8,015 | ) |   | (6,390 | ) |
|                                                                       |                           |   |  |  |   |  |  |   |
| Net cash provided by financing activities                                  |                           |   |   | 56,355 |   |   | 105,174 |   |
|                                                                       |                           |   |  |  |   |  |  |   |
| Increase (decrease) in cash and cash equivalents                           |                           |   |   | 18,245 |   |   | (45,537 | ) |
| Equity adjustment from foreign currency translation                        |                           |   |   | 603 |   |   | (891 | ) |
| Cash and cash equivalents, beginning of period                             |                           |   |   | 35,993 |   |   | 166,086 |   |
|                                                                       |                           |   |  |  |   |  |  |   |
| Cash and cash equivalents, end of period                                   |                           |   | $ | 54,841 |   | $ | 119,658 |   |
|                                                                       |                           |   |  |  |   |  |  |   |
|                                                                       |                           |   |   |   |   |   |   |   |
| **Supplemental Cash Flow Information:**                                    |                           |   |   |   |   |   |   |   |
| Cash paid for interest                                                     |                           |   | $ | 18,634 |   | $ | 4,421 |   |
|                                                                       |                           |   |   |   |   |   |   |   |
| **Supplemental Disclosure of Noncash Investing and Financing Activities:** |                           |   |   |   |   |   |   |   |
| Acquisition of COR Therapeutics, Inc., including direct transaction costs  |                           |   | $ | 1,833,329 |   | $ | — |   |
| Equipment acquired under capital leases                                    |                           |   |   | 21,470 |   |   | 14,041 |   |
| Construction costs for laboratory and office space                         |                           |   |   | 2,224 |   |   | 12,894 |   |
| Conversion of subordinated debt to common stock                            |                           |   |   | — |   |   | 12,602 |   |
| Write off of capital assets                                                |                           |   |   | — |   |   | 558 |   |
| Reclassification of debt issuance costs to additional paid-in capital      |                           |   |   | — |   |   | 122 |   |

See notes to condensed consolidated financial statements.

5

----

**Millennium Pharmaceuticals, Inc.                               Notes to Condensed Consolidated Financial Statements**

**1.        Basis of Presentation**

        The accompanying condensed consolidated financial statements have been prepared in accordance with accounting principlesgenerally accepted in the United States for interim financial information and with the instructions to Form 10-Q and Article 10 ofRegulation S-X.  Accordingly, they do not include all of the information and footnotes required by generally accepted accountingprinciples for complete financial statements.  In the opinion of management, all adjustments, consisting of normal recurring accrualsand revisions of estimates, considered necessary for a fair presentation of the accompanying condensed consolidated financialstatements have been included.  Interim results for the three and six month periods ended June 30, 2002 are not necessarilyindicative of the results that may be expected for the year ended December 31, 2002.  For further information, refer to the financialstatements and accompanying footnotes included in the Company's Annual Report on Form 10-K for the fiscal year ended December 31,2001, which was filed with the Securities and Exchange Commission (SEC) on March 7, 2002.

**2.        Summary of Significant Accounting Policies**

*(a)        Cash Equivalents and Marketable Securities*

        Cash equivalents consist principally of money market funds and corporate bonds with maturities of three months or less at thedate of purchase. Marketable securities consist of high-grade corporate bonds, asset-backed and U.S. government agency securities.

        Management determines the appropriate classification of marketable securities at the time of purchase and reevaluates suchdesignation at each balance sheet date. Marketable securities at June 30, 2002 and December 31, 2001 are classified as"available-for-sale." Available-for-sale securities are carried at fair value, with the unrealized gains and losses reported in aseparate component of stockholders' equity. The cost of debt securities in this category is adjusted for amortization of premiums andaccretion of discounts to maturity. Such amortization and accretion is included in investment income. Realized gains are included ininvestment income.  Realized losses and declines in value judged to be other-than-temporary on available-for-sale securities areincluded in realized loss on marketable securities. The cost of securities sold is based on the specific identification method.Interest and dividends on securities classified as available-for-sale are included in investment income.

        The Company recorded realized gains on marketable securities of $4.8 million and $2.8 million for the quarters ended June 30,2002 and 2001, respectively, and $12.0 million and $5.2 million for the six months ended June 30, 2002 and 2001, respectively.  TheCompany recorded realized losses on marketable securities of $14.7 million and $0.6 million for the quarters ended June 30, 2002 and2001, respectively, and $17.1 million and $0.6 million for the six months ended June 30, 2002 and 2001, respectively.

*(b)        Inventory*

        Inventory represents bulk materials used in the production of INTEGRILIN®  (eptifibatide) Injection and INTEGRILIN finished goodsinventory on hand, valued at cost.  Inventory consists of the following (in thousands):

|           |   | **June 30, 2002** |
|----------------|--------|-------------------|
| Bulk materials |   | $                 | 59,081 |
| Finished goods |   |              | 44,443 |
|           |   |                   |
|           |   | $                 | 103,524 |
|           |   |                   |

6

----

**Millennium Pharmaceuticals, Inc.                               Notes to Condensed Consolidated Financial Statements (continued)**

*(c)        Goodwill and Intangible Assets*

        Intangible assets consist of specifically  identified  intangible  assets.  Goodwill is the excess of any purchase price over theestimated fair market value of net tangible assets acquired not allocated to specific intangible  assets.  Amortization  of intangibles is computed  using the  straight-line  method over the useful lives of the respectiveassets.  Accumulated  amortization on intangible  assets was $25.8 million and  $12.7 million at June 30, 2002 and  December 31,  2001,respectively.

        In July 2001,  the Financial  Accounting  Standards Board ("FASB") issued Statement of Financial  Accounting  Standards  ("SFAS")No. 142,  "Goodwill and Other Intangible  Assets." Under SFAS No. 142,  goodwill and indefinite  lived intangible  assets are no longeramortized but are reviewed annually,  or more frequently if impairment  indicators arise, for impairment.  Separable  intangible assetsthat are not deemed to have an  indefinite  life will  continue to be  amortized  over their  useful  lives.  The Company  adopted SFASNo. 142 effective January 1,  2002 and reclassified  amounts to goodwill which were previously  allocated to assembled workforce.  Uponadoption,  the Company  ceased the  amortization  of goodwill.  The Company  completed its  transitional  assessment of goodwill and noimpairment loss was recognized.

        The following unaudited pro forma adjusted net losses have been prepared as if SFAS No. 142 had been applied retroactively:

|                                           | Three Months Ended June 30, |     | Six Months Ended June 30, |   |
|------------------------------------------------|-----------------------------|----------|---------------------------|--------|
||
| (in thousands, except per share amounts)  |                        |
| Net loss                                       | $                           | (107,739 | )                         | $      | (46,730 | ) | $ | (411,600 | ) | $ | (99,798 | ) |
| Add back: Goodwill amortization                |                        | —   |                      |   | 14,274 |   |   | — |   |   | 28,786 |   |
| Add back: Assembled workforce amortization     |                        | —   |                      |   | 295 |   |   | — |   |   | 590 |   |
|                                           |                             |          |                      |        |  |   |  |  |   |  |  |   |
| Adjusted net loss                              | $                           | (107,739 | )                         | $      | (32,161 | ) | $ | (411,600 | ) | $ | (70,422 | ) |
|                                           |                             |          |                      |        |  |    |  |  |   |  |  |    |
| *Amounts per common share, basic and diluted:* |                        |     |                      |   |   |   |   |   |   |   |   |   |
| Net loss                                       | $                           | (0.38    | )                         | $      | (0.21 | ) | $ | (1.53 | ) | $ | (0.46 | ) |
| Add back: Goodwill amortization                |                        | —   |                      |   | 0.06 |   |   | — |   |   | 0.13 |   |
| Add back: Assembled workforce amortization     |                        | —   |                      |   | 0.00 |   |   | — |   |   | 0.00 |   |
|                                           |                             |          |                      |        |  |   |  |  |   |  |  |   |
| Adjusted net loss                              | $                           | (0.38    | )                         | $      | (0.15 | ) | $ | (1.53 | ) | $ | (0.33 | ) |
|                                           |                             |          |                      |        |  |    |  |  |   |  |  |    |
| Shares                                         |                        | 282,693  |                      |   | 217,779 |   |   | 268,382 |   |   | 216,582 |   |
|                                           |                             |          |                      |        |  |    |  |  |   |  |  |    |

*(d)        Revenue Recognition*

        Product  revenue  includes the Company's  share of profits from the sale of INTEGRILIN®  (eptifibatide)  Injection in copromotionterritories  by  Schering-Plough  Ltd.  and  Schering  Corporation  (collectively  "Schering").  Also  included in product  revenue arereimbursements  of certain  manufacturing-related  expenses and royalties from Schering on sales of INTEGRILIN  outside the copromotionterritory.  The Company  recognizes  revenue when Schering ships  INTEGRILIN to wholesalers  and records it net of allowances,  if any.The Company's costs of product revenue consist of certain  manufacturing-related  and advertising and promotional  expenses  associatedwith the sale of INTEGRILIN within copromotion territories.  The Company defers certain  manufacturing-related  expenses until the timeSchering ships related product to its customers inside and outside copromotion  territories.  Advertising and promotional  expenses areexpensed as incurred.  Deferred  revenue  includes  payments from Schering  received prior to the period in which the related  contract

7

**Millennium Pharmaceuticals, Inc.                               Notes to Condensed Consolidated Financial Statements (continued)**

revenues are earned.  Deferred  revenue also includes cash advances from Schering to the Company for the Company's  prepayments  to itsmanufacturers of INTEGRILIN®  (eptifibatide)  Injection.

        Effective October 1,  2000,  Millennium changed its method of accounting for revenue under strategic alliances in accordance withStaff  Accounting  Bulletin  No. 101 ("SAB 101"),  *Revenue  Recognition  in Financial  Statements*.  Previously,  the Company hadrecognized  revenue relating to  non-refundable,  up-front,  license and milestone  payments and certain research funding payments fromits strategic partners in accordance with the contract.  Under the new accounting method adopted retroactively to January 1,  2000, theCompany  recognizes  revenue from  non-refundable,  up-front,  license and  milestone  payments,  not  specifically  tied to a separateearnings process, ratably over the term of the research contract.

        When  payments are  specifically  tied to a separate  earnings  process,  revenue is  recognized  when the  specific  performanceobligation  associated  with the payment is completed.  Performance  obligations  typically  consist of  significant  milestones in thedevelopment life cycle of the related technology,  such as initiation of clinical trials,  filing for approval with regulatory agenciesand approvals by regulatory  agencies.  In addition,  when appropriate,  the Company  recognizes revenue from certain research paymentsbased upon the level of research services performed during the period of the research contract.

        The cumulative  effect of the change on prior years resulted in a charge to income of  $107.7 million,  which was included in theloss for the year ended  December 31,  2000. The amount of revenue  recognized in the three and six months ended June 30, 2002 that wasincluded in the  cumulative  effect of change in  accounting  principle  and was  recognized in prior years was $11.1 million and $22.1million,  respectively.  The amount of revenue  recognized  in the three and six months  ended June 30,  2001 that was  included in thecumulative  effect  of change in  accounting  principle  and was  recognized  in prior  years  was  $12.2  million  and $22.3  million,respectively.

*(e)        Segment Information*

        SFAS No. 131, "Disclosures about Segments of an Enterprise and Related Information" (SFAS No. 131), establishes standards forthe way that public business enterprises report information about operating segments in annual financial statements and requires thatthose enterprises report selected information about operating segments in interim financial reports. SFAS No. 131 also establishesstandards for related disclosures about products and services, geographic areas, and major customers.

        The Company operates in one business segment,  which primarily  focuses on the discovery,  development and  commercialization  ofproprietary  therapeutic  and diagnostic  human  healthcare  products and services.  All of the Company's  product revenue is currentlyrelated to sales of INTEGRILIN.  Revenues from one strategic partner accounted for approximately  39.9% and29.6% of  strategic  partner  revenues  for the quarters  ended June 30, 2002 and 2001,  respectively  and 38.8% and 30.0% of strategicpartner  revenues for the six months ended June 30, 2002 and 2001,  respectively.  Revenues from a second strategic  partner  accountedfor approximately  23.1% and 18.4% of strategic partner revenues for the quarters ended June 30, 2002 and 2001,  respectively and 23.2%and 19.8% of  strategic  partner  revenues  for the six  months  ended  June 30,  2002 and 2001,  respectively.  Revenues  from a thirdstrategic partner  accounted for  approximately  22.2% and 16.9% of strategic partner revenues for the quarters ended June 30, 2002 and2001,  respectively and 21.4% and 18.3% of strategic  partner  revenues for the six months ended June 30, 2002 and 2001,  respectively.There were no other significant strategic partners during the three and six months ended June 30, 2002 and 2001, respectively.

*(f)        Information Concerning Market and Source of Supply Concentration*

        Millennium and Schering copromote INTEGRILIN in the United States and share any profits and losses.  Together with Schering andGenentech, Inc., the Company also copromotes INTEGRILIN for use with Genentech's fibrinolytic, or clot-dissolving, drugs TNKaseTM (tenecteplase) andActivase® (alteplase) across the United States.  INTEGRILIN has received regulatory approval in the European Union and a number of othercountries for various indications.  The Company has exclusively licensed to Schering rights to market INTEGRILIN outside the UnitedStates, and Schering pays the Company royalties based on these sales of INTEGRILIN.  The 

8

**Millennium Pharmaceuticals, Inc.                               Notes to Condensed Consolidated Financial Statements (continued)**

Company has long-term supply arrangementswith two suppliers for the bulk product and with another two suppliers, one of which is Schering, for the filling and final packagingof INTEGRILIN®  (eptifibatide)  Injection.

*(g)        Net Loss Per Common Share*

        Basic net loss per common share is computed using the weighted average number of common shares outstanding during the period.Diluted net loss per common share is typically computed using the weighted average number of common and dilutive common equivalentshares from stock options, warrants and convertible debt using the treasury stock method. However, for all periods presented, dilutednet loss per share is the same as basic net loss per share because the Company reported a net loss and therefore the inclusion ofweighted average shares of common stock issuable upon the exercise of stock options, warrants and convertible debt would beantidilutive.

*(h)        Comprehensive Loss*

        Comprehensive loss was $79.8 million and $50.1 million for the three months ended June 30, 2002 and 2001, respectively and $413.3million and $87.5 million for the six months ended June 30, 2002 and 2001, respectively.  Comprehensive loss is composed of netloss, unrealized gains and losses on marketable securities and cumulative foreign currency translation adjustments.  Unrealized gainsand losses on marketable securities includes the reclassification to realized losses on marketable securities in the condensedconsolidated statement of operations for the three and six months ended June 30, 2002 of unrealized losses of $14.6 million due to adecline in the market value of an investment in marketable securities that was deemed to be not temporary.  Accumulated othercomprehensive income at June 30, 2002 included $17.9 million of unrealized gains on marketable securities with the balanceattributable to cumulative foreign currency translation adjustments.

**3.        COR Acquisition**

        On February 12, 2002, the Company acquired COR Therapeutics, Inc. ("COR") for an aggregate purchase price of $1.8 billionprimarily consisting of 55.1 million shares of Millennium common stock pursuant to the merger agreement between the Company and COR.This calculation is based on COR outstanding common stock at February 12, 2002 using the conversion ratio of 0.9873 of a share ofMillennium common stock for each share of outstanding COR common stock. In addition, options to purchase approximately 6.2 millionshares of COR common stock with a weighted average exercise price of $12.90 were assumed by Millennium pursuant to the merger andconverted into options to purchase approximately 6.1 million shares of Millennium common stock.

        The total cost of the merger was determined as follows (in thousands):
Fair value of Millennium shares (calculated using $30.57 per share average fair value for the three days prior to and after announcement of the merger)$1,685,334  Value of COR options assumed net of intrinsic value of unvested options127,714  Millennium transaction costs, consisting primarily of financial advisory, legal and accounting fees20,281  $1,833,329 
        The fair value of options assumed was determined using the Black-Scholes method assuming expected lives ranging from one to fiveyears, a risk-free rate of 4.35%, volatility of 86.88% and no expected dividends. In accordance with FASB Interpretation No. 44, orFIN 44, Accounting for Certain Transactions Involving

9

**Millennium Pharmaceuticals, Inc.                               Notes to Condensed Consolidated Financial Statements (continued)**

Stock Compensation--an Interpretation of APB 25, a portion of the intrinsic value of unvested options of COR has been allocated to deferred stock compensation. Deferred stock compensation will be amortized ona straight-line basis over the estimated remaining vesting period of the related options.

        The transaction was recorded as a purchase for accounting purposes and the Company's condensed consolidated financial statements includeCOR's operating results from the date of the acquisition.  The purchase price was allocated to the assets purchased and theliabilities assumed based upon their respective fair values, with the excess of the purchase price over the estimated fair value ofnet tangible assets allocated to specific intangible assets and goodwill as follows (in thousands):
Net tangible assets acquired$37,585In-process research and development 242,000Identifiable intangible assets(primarily developed  technology--13 year useful life and  trademark--indefinite life) 494,000Goodwill 1,059,744   $1,833,329  
        The Company recorded a one-time, noncash charge to operations in the quarter ended March 31, 2002 and the six months ended June30, 2002 related to $242.0 million for acquired in-process research and development.  The valuation of acquired in-process researchand development represents the estimated fair value related to incomplete projects that, at the time of the acquisition, had noalternative future use and for which technological feasibility had not been established.

        The income approach was used to establish the fair values of developed technology, trademark and acquired in-processresearch and development.  This approach establishes the fair value of an asset by estimating the after-tax cash flows attributableto the asset over its useful life and then discounting these after-tax cash flows back to a present value.  The discounting processuses a rate of return commensurate with the time value of money and investment risk factors.

        The following unaudited pro forma consolidated results of operations have been prepared as if the acquisition of COR hadoccurred as of January 1, 2001:
 Three Months Ended June 30, Six Months Ended June 30,  2002 2001 2002 2001 **(in thousands, except per share amounts)**              Total revenues$91,854 $97,129 $177,978 $170,273                   Net loss$(107,739)$(52,884)$(180,744)$(117,172)                  *Amounts per common share:*            Net loss, basic and diluted$(0.38)$(0.19)$(0.67)$(0.43)             Weighted average shares, basic and diluted 282,693  272,907  268,382  271,710      
        The pro forma net loss and net loss per share amounts for each period above exclude the acquired in-process research anddevelopment charge.   The pro forma consolidated results do not purport to be indicative of results that would have occurred had theacquisition been in effect for the periods presented, nor do they purport to be indicative of the results that will be obtained inthe future.

10

**Millennium Pharmaceuticals, Inc.                               Notes to Condensed Consolidated Financial Statements (continued)**

**4.        Revenues and Strategic Alliances**

        The Company has formed strategic alliances with major participants in marketplaces where its discovery expertise and technologyplatform are applicable. These agreements include alliances based on the transfer of technology platforms, alliances that combinetechnology-transfer with a focus on a specific disease or therapeutic approach, and disease-focused programs under which the Companyconducts research funded by its partners. The Company's disease-based alliances and alliances that combine technology-transfer with adisease focus are generally structured as research collaborations. Under these arrangements, the Company performs research in aspecific disease area aimed at discoveries leading to novel pharmaceutical (small molecule) products. These alliances generallyprovide research funding over an initial period, with renewal provisions, varying by agreement. Under these agreements, the Company'spartners may make up-front payments, additional payments upon the achievement of specific research and product developmentmilestones, ongoing research funding and/or royalty payments or in some cases profit-sharing payments to the Company based upon anyproduct sales resulting from the collaboration.

        In each of March 2002 and June 2002, Abbott  Laboratories  ("Abbott") made a $28.6 million purchase of Millennium common stock pursuant tothe March 2001 Investment Agreement between the Company and Abbott.

**5.        Convertible Debt**

        In connection with the COR acquisition, the Company assumed COR's $600.0 million in convertible debt resulting from twoofferings: the 5.0% convertible subordinated notes due March 1, 2007 that are convertible into Millennium common stock at any timeprior to maturity at a price equal to $34.21 per share (the "5.0% notes") and the 4.5% convertible senior notes due June 15, 2006that are convertible into Millennium common stock at any time prior to maturity at a price equal to $40.61 per share (the "4.5%notes").  Under the terms of the notes, the Company is required to make semi-annual interest payments on the outstanding principalbalance of the 5.0% notes on March 1 and September 1 of each year and of the 4.5% notes on June 15 and December 15 of each year.  Allrequired interest payments to date have been made.  On March 14, 2002, the Company, as required by the terms of the notes, commencedcash repurchase offers to the noteholders in amounts equal to 100% of the principal amounts of the notes plus interest accrued andunpaid through April 28, 2002. These offers and the related withdrawal rights expired on April 29, 2002.

        On April 22, 2002, the Company amended the terms of the 5.0% notes and 4.5% notes to induce noteholders to hold such notes untilat least April 29, 2003.  Specifically, the Company has amended the 4.5% notes to permit noteholders to require the Company torepurchase these notes for cash at a price of $1,095 per $1,000 of principal amount on April 29, 2003, and the Company has amendedthe 5.0% notes to permit noteholders to require the Company to repurchase these notes for cash at a price of $1,085 per $1,000 ofprincipal amount on April 29, 2003.  These put options placed on the notes are derivative instruments.  SFAS No. 133, "Accounting forDerivative Instruments and Hedging Activities" requires all derivative instruments to be recorded in the balance sheet at fair value.The fair value of these derivative instruments was determined to be $54.0 million in aggregate and was recorded by the Company as aliability on the balance sheet and as a non-cash charge to earnings in the second quarter of 2002. Changes in the fair value of thesederivatives will be recognized in income.

        At June 30, 2002, the Company had $599.9 million in the aggregate of outstanding principal of 5.0% notes and 4.5% notes.

        The Company has 5.5% convertible subordinated notes due January 15, 2007 (the "5.5% notes") that are convertible into Millenniumcommon stock at any time prior to maturity at a price equal to $42.07 per share, subject to adjustment, unless previously repurchasedor redeemed by the Company under certain circumstances.  Under the terms of the 5.5% notes, the Company is required to makesemi-annual interest payments on the outstanding principal balance of the 5.5% notes on January 15 and July 15 of each year.  Allrequired interest payments to date have been made.

11

**Millennium Pharmaceuticals, Inc.                               Notes to Condensed Consolidated Financial Statements (continued)**

        During the six months ended June 30, 2001, the Company paid $2.6 million in cash to certain holders of the 5.5% notes in order toinduce the conversion of $12.6 million of their notes into approximately 0.3 million shares of Millennium common stock.   These cashpayments were expensed during the six months ended June 30, 2001.  Interest accrued through the date of conversion was charged tointerest expense and was paid upon conversion.  At June 30, 2002, the Company had $83.3 million of outstanding principal of 5.5%notes.

12

**Item 2.    Management's Discussion and Analysis of Financial Condition and Results of Operations**

**Overview**

        We are a leading biopharmaceutical company focused on applying our comprehensive and integrated science and technologyplatform to discover and accelerate the development of breakthrough drugs and predictive medicine products. We expect that thesedrugs and products ultimately will enable physicians to more closely customize medical treatment by combining knowledge of thegenetic basis for disease and the genetic characteristics of a patient. We primarily focus our research and development andcommercialization activities in four key disease areas: cardiovascular, oncology, inflammatory and metabolic. We view the pursuit ofmergers, acquisitions and product in-licensing as important in achieving our business goals.

        Our management's discussion and analysis of our financial condition and results of our operations are subject to importantfactors that could cause our actual results to differ materially from those indicated. See "Risk Factors That May Affect Results."

*Alliances*

        We have entered into research, development, technology-transfer and commercialization arrangements with major pharmaceuticaland biotechnology companies relating to a broad range of therapeutic and predictive medicine products and services. These alliancesprovide us with the opportunity to receive various combinations of equity investments, license fees and research funding, and mayprovide certain additional payments contingent upon our achievement of research and regulatory milestones and royalties and/or profitshares if our collaborations are successful in developing and commercializing products. The alliances that we consider material toour business are:
 • a collaboration agreement with Schering-Plough Ltd. and Schering Corporation (collectively "Schering") to jointly develop and commercialize INTEGRILIN® (eptifibatide) Injection on a worldwide basis;     • an agreement with Genentech to copromote INTEGRILIN with Genentech's fibrinolytic, or clot-dissolving drugs, TNKaseTM (tenecteplase) and Activase® (alteplase) across the United States;     • a purchase and sale agreement by and among ILEX Oncology, Inc. and us for the sale of our interests in CAMPATH® (alemtuzumab) humanized monoclonol antibody;     • a joint development agreement with BZL Biologics, L.L.C. for immunotoxin and radiolabeled products;     • a joint development and commercialization agreement with Abbott Laboratories in metabolic diseases;     • a technology transfer agreement and joint development and commercialization agreement with Aventis Pharmaceuticals, Inc. in inflammatory disease;     • a collaboration agreement with Becton, Dickinson and Company focused primarily on DiagnomicsTM products for specified cancers;     • a research agreement with Bayer AG in cardiovascular disease, and certain areas of oncology, pain, hematology, atherosclerosis, thrombosis, urology and viral infections; and     • a research alliance and technology transfer agreement with Monsanto Company in plant agriculture.
        Historically, we have primarily derived our revenue from payments from our strategic alliances with major pharmaceuticalcompanies. Beginning in the first quarter of 2002 in connection with our acquisition of COR, we began recognizing product revenuethat principally relates to our share of the profits from the sale of

13

INTEGRILIN® (eptifibatide) Injection, in copromotion territoriesby Schering.  Additionally, product revenues include recognition of reimbursement of certain manufacturing-related expenses androyalties from Schering on sales of INTEGRILIN outside the copromotion territory. 

*Acquisitions*

        As part of our business strategy, we continually consider joint development, merger and acquisition opportunities that mayprovide us with products on the market, products in later stage development or additional capabilities necessary to accelerate ourdownstream drug discovery efforts.

        *COR.*        On February 12, 2002, we acquired COR Therapeutics, Inc. ("COR") through the issuance of approximately 55.1 millionshares of our common stock. The number of shares of our common stock issued in the acquisition was calculated using the conversionratio of .9873 of a share of our common stock for each share of outstanding COR common stock outstanding at the time of the merger.In addition, options to purchase approximately 6.2 million shares of COR common stock were assumed by us and converted into optionsto purchase approximately 6.1 million shares of our common stock. The transaction has been recorded as a purchase for accountingpurposes and the purchase price was allocated, based upon an independent valuation, to the assets purchased and liabilities assumedbased upon their respective fair values. We allocated the excess of the purchase price over the estimated fair market value of nettangible assets acquired to in-process research and development, developed technology and trademark and goodwill.  Through themerger, we added approximately 300 new employees, a facility in South San Francisco, California and acquired INTEGRILIN andsubstantial research and development capabilities in the areas of cardiovascular disease and oncology.

        In connection with the COR acquisition, we assumed COR's $600.0 million in convertible debt resulting from two offerings:the 5.0% convertible subordinated notes due March 1, 2007 (the "5.0% notes") and the 4.5% convertible senior notes due June 15, 2006(the "4.5% notes"). As a result, the noteholders have an option to convert their notes into our common stock.  On March 14, 2002, asrequired by the terms of the notes, we made a cash repurchase offer to the noteholders in amounts equal to 100% of the principalamounts of the notes plus interest accrued and unpaid through April 28, 2002. These offers and the related withdrawal rights expiredon April 29, 2002.

        On April 22, 2002 we amended the terms of the 5.0% notes and 4.5% notes to induce noteholders to hold such notes until at leastApril 29, 2003.  Specifically, we amended the 4.5% notes to permit noteholders to require us to repurchase these notes for cash at aprice of $1,095 per $1,000 of principal amount on April 29, 2003 and we amended the 5.0% notes to permit noteholders to require us torepurchase these notes for cash at a price of $1,085 per $1,000 of principal amount on April 29, 2003.   These put options placed onthe notes are derivative instruments.  Statement of Financial Accounting Standards ("SFAS") No. 133, "Accounting for DerivativeInstruments and Hedging Activities" requires all derivative instruments to be recorded in the balance sheet at fair value. The fairvalue of these derivative instruments was determined to be $54.0 million in aggregate and we recorded a liability on the balancesheet and a non-cash charge in the quarter ended June 2002. Changes in the fair value of these derivatives will be recognized inincome.

*Expansion of Operations*

        During 2002 and 2001, we have expanded and expect to continue to expand our operations through internal growth, additionalstrategic alliances and the COR acquisition. To build development and commercialization capabilities, in 2002 and 2001 we hired staffin critical functions, including global commercial operations, clinical research and operations, strategic product development,government relations and regulatory affairs, as well as in other support areas.

        As a result of the COR acquisition, we are incurring additional significant expenses for research and development and todevelop, train, maintain and manage our sales force for INTEGRILIN.

        We expect to continue to pursue additional alliances and to consider joint development, merger, or acquisition opportunitiesthat may provide us with access to products on the market or in later stages of commercial development than those represented withinour current programs. We expect that we will incur increasing expenses and may incur increasing operating losses for at least thenext several years, primarily due

14

to expansion of facilities and research and development programs and as a result of our efforts toadvance acquired products or our own development programs to commercialization. Our results of operations for any period may not beindicative of future results as our revenues under strategic alliance and licensing arrangements, product revenue and from productsales may fluctuate from period to period or year to year.

**Critical Accounting Policies**

        In December 2001, the SEC requested that all registrants discuss their most "critical accounting policies" in management'sdiscussion and analysis of financial condition and results of operations. The SEC indicated that a "critical accounting policy" isone which is both important to the portrayal of the company's financial condition and results and requires management's mostdifficult, subjective or complex judgments, often as a result of the need to make estimates about the effect of matters that areinherently uncertain. While our significant accounting policies are more fully described in Note 2 to our consolidated financialstatements included in our Form 10-K, we believe the following accounting policies to be critical:

        *Revenue*—We have formed strategic alliances with major pharmaceutical companies. These agreements include alliances based onthe transfer of technology, alliances which combine technology-transfer with a focus on a specific disease or therapeutic approach,and disease-focused programs under which we conduct research funded by our partners. Our disease-based alliances and alliances whichcombine technology-transfer with a disease focus are generally structured as research collaborations. Under these arrangements, weperform research in a specific disease area aimed at discoveries leading to novel pharmaceutical (small molecule) products. Thesealliances generally provide research funding over an initial period, with renewal provisions, varying by agreement. Under theseagreements, our partners may make up-front payments, additional payments upon the achievement of specific research and productdevelopment milestones, ongoing research funding and/or royalty payments or in some cases make profit-sharing payments to us basedupon any product sales resulting from the collaboration.

        Product revenue includes our share of profits from the sale of INTEGRILIN® (eptifibatide) Injection in copromotion territoriesby Schering.  Also included in product revenue are reimbursements to us by Schering of certain manufacturing-related expenses formaterials used outside the copromotion territory and royalties from Schering on sales of INTEGRILIN outside the copromotionterritory.    We recognize revenue when Schering ships related product to wholesalers and record it net of allowances, if any.  Ourcosts of product revenue consist of certain manufacturing-related and advertising and promotional expenses associated with the saleof INTEGRILIN within copromotion territories.  We defer certain manufacturing-related expenses until the time Schering ships relatedproduct to its customers inside and outside copromotion territories.  Advertising and promotional expenses are expensed as incurred.Deferred revenue includes payments from Schering received prior to the period in which the related contract revenues are earned.Deferred revenue also includes cash advances from Schering to us for our prepayments to our manufacturers of INTEGRILIN.

        Effective October 1, 2000, we changed our method of accounting for revenue recognition in accordance with Staff AccountingBulletin  No. 101 ("SAB 101"), *Revenue Recognition in Financial Statements*. Previously, we had recognized revenue relating tonon-refundable, up-front, license and milestone payments and certain research funding payments from our strategic partners inaccordance with the contract. Under the new accounting method adopted retroactively to January 1, 2000, we recognize revenue fromnon-refundable, up-front, license and milestone payments, not specifically tied to a separate earnings process, ratably over the termof the research contract. When the period of deferral cannot be specifically identified from the contract, management estimates theperiod based upon other critical factors contained within the contract. We continually review these estimates which could result in achange in the deferral period. When payments are specifically tied to a separate earnings process, revenue is recognized when thespecific performance obligation associated with the payment is completed. Performance obligations typically consist of significantmilestones in the development life cycle of the related technology, such as initiation of clinical trials, filing for approval withregulatory agencies and approvals by regulatory agencies. In addition, when appropriate, we recognize revenue from certain researchpayments based upon the level of research services performed during the period of the research contract. The cumulative effect of thechange on prior years resulted in a charge to income of $107.7 million, which was included in the loss for the year endedDecember 31, 2000.

        In connection with our adoption of SAB 101, we began recognizing the research funding portion of our Bayer alliance on apercentage-of-completion basis. The percentage-of-completion is determined based upon

15

the actual level of work performed during the period as compared to management's estimate of the total work to be performed under the alliance. The estimates are continuallyreviewed and adjusted as necessary, as experience develops or new information becomes known.

        *Inventory*—Inventory represents bulk materials used in the production of INTEGRILIN® (eptifibatide) Injection and INTEGRILINfinished goods inventory on hand, valued at cost.  Inventories are reviewed periodically for slow-moving or obsolete status based onsales activity, both projected and historical. If product sales differ from projections, inventory may not be fully utilized andcould be subject to impairment.

**Accounting Pronouncements**

        In July 2001, the Financial Accounting Standards Board ("FASB") issued SFASNo. 142, "Goodwill and Other Intangible Assets." Under SFAS No. 142, goodwill and indefinite lived intangible assets are no longeramortized but are reviewed annually, or more frequently if impairment indicators arise, for impairment. Separable intangible assetsthat are not deemed to have an indefinite life will continue to be amortized over their useful lives. The Company adopted SFASNo. 142 effective January 1, 2002 and reclassified amounts to goodwill which were previously allocated to assembled workforce. Uponadoption, the Company ceased the amortization of goodwill.  The Company completed its transitional assessment of goodwill and noimpairment loss was recognized.

**Results of Operations**

**Quarters Ended June 30, 2002 and June 30, 2001**

        For the three months ended June 30, 2002 (the "2002 Quarterly Period"), we reported a net loss of $107.7 million or $0.38 perbasic and diluted share as compared to a net loss of $46.7 million or $0.21 per basic and diluted share for the three months endedJune 30, 2001 (the "2001 Quarterly Period").

        Revenues increased to $91.9 million for the 2002 Quarterly Period from $59.1 million for the 2001 Quarterly Period, andincludes $44.9 million of product revenue based upon worldwide sales of INTEGRILIN and $46.9 million of strategic alliance revenue.  Theincrease is attributable to our share of profits from INTEGRILIN copromoted by us and Schering.  As reported by Schering, worldwidesales of INTEGRILIN for the 2002 Quarterly Period were $77.7 million and U.S. sales were $71.3 million, an increase in each case of16 percent from the same period last year.  Also included in product revenue are reimbursements of certain manufacturing-relatedexpenses and royalties from Schering on sales of INTEGRILIN outside the copromotion territory.  Revenue under strategic alliancesdecreased due to the termination of certain of our early strategic alliances.   We expect that our revenue mix will continue thisshift as we develop our product pipeline and evolve our partnerships.

        Included in revenue for the quarterly periods presented in 2002 and 2001 is $11.1 million and $12.2 million, respectively, ofrevenue that was recognized in prior years relating to the adoption of SAB 101.

        Research and development expenses increased to $122.4 million in the 2002 Quarterly Period from $94.6 million for the 2001Quarterly Period.  The increase was primarily attributable to our continued investment in building a sustainable product pipeline,with increases in personnel and facilities, expenses relating to clinical trials and preclinical product candidates, and consulting.

        As of June 30, 2002, we had ten product candidates in various stages of clinical trials. Completion of clinical trials maytake several years or more, but the length of time can vary substantially according to the type, complexity, novelty and intended useof a product candidate. In 2001, we initiated a Phase II trial of our lead oncology candidate, VELCADETM (bortezomib) for Injection(formerly MLN341, LDP 341 and PS-341), in patients with hematologic cancers and Phase I trials for potential treatment of patientswith solid tumors. In June 2002, we received fast track designation from the Food and Drug Administration ("FDA") for VELCADE and weinitiated a pivotal Phase III clinical trial of VELCADE in patients with multiple myeloma.  Also in 2001, we initiated Phase IItrials of MLN02 in patients with ulcerative colitis and of MLN977 in patients with asthma.  During July 2002, we discontinued thedevelopment of our oral MLN977 program based upon the findings of a multi-center Phase II trial initiated in 2001 that showed thedrug was clinically active in study patients, but that three patients experienced elevations in liver enzymes that were likelydrug-related.  The radio-labeled version of our anti-PSMA (prostate specific membrane antigen) antibody, MLN591 is in Phase I trialin patients with

16

hormone-refractory prostate cancer. In November 2001, we initiated a Phase I trial of our first genomically-derivedmolecule, MLN4760, for the potential treatment of obesity. CMR International estimates that clinical trials in our franchise areasare typically completed over the following timelines:
Clinical Phase  Estimated CompletionPeriod                 Phase I 1-2 years                 Phase II 2-3 years                 Phase III 2-3 years 
        Upon successful completion of Phase III trials, we intend to submit the results to the FDA to support regulatory approval ofthe product. However, we cannot be certain that any of our products will prove to be safe or effective, will receive regulatoryapprovals, or will be successfully commercialized.

        The duration and the cost relating to preclinical testing and clinical trials may vary significantly over the life of aproject. Our joint development arrangements with our strategic partners also result in variability in our development costs. Ourprimary mechanism for budgeting and tracking these costs is by type of cost incurred. The types of costs include the followingcategories: personnel costs, clinical costs, laboratory costs, technology license fees, research costs and facilities costs.

        Selling, general and administrative expenses increased to $40.1 million for the 2002 Quarterly Period from $19.4 million forthe 2001 Quarterly Period. This increase represents a full quarter of expenses from our commercial organization that were not presentlast year as well as increased expenses due to the expansion of our business groups, facilities and infrastructure necessary tosupport the development of our pipeline and growth in all areas of our business. Significant increases were primarily in personnelexpenses, consulting and facility expenses.

        Cost of product revenue consists of certain manufacturing-related and advertising and promotional expenses associated with thesale of INTEGRILIN® (eptifibatide) Injection within copromotion territories.  Cost of product revenue fluctuates in relation tothe domestic sales of INTEGRILIN and as we incur more or less of the joint activities that we undertake in our collaboration withSchering.

        Amortization of intangible assets in the 2002 Quarterly Period relates to specifically identified intangible assets from theCOR, LeukoSite, Inc. ("LeukoSite") and Cambridge Discovery Chemistry Limited ("CDC") acquisitions.  Amortization of intangible assetsin the 2001 Quarterly Period relates to existing technology, assembled workforce and goodwill acquired through the acquisitions ofLeukoSite and CDC. Amortization expense decreased to $9.8 million in the 2002 Quarterly Period from $16.0 million in the 2001Quarterly Period due to the adoption of SFAS No. 142, "Goodwill and Intangible Assets."  Following our adoption of SFAS 142 effectiveas of January 1, 2002, we continue to amortize specifically identifiable intangible assets and ceased amortizing goodwill andassembled workforce which was reclassified to goodwill.

        Investment income increased to $29.6 million for the 2002 Quarterly Period from $27.1 million for the 2001 Quarterly Period dueto an increase in our average balance of cash, cash equivalents and marketable securities. During the 2002 Quarterly Period, werecorded a $14.6 million write-down relating to certain bond investments.  Our investments are made primarily in government andcorporate bonds of high quality and a small portion of our holdings have been affected by the sudden and dramatic changes in thefundamentals of some of our bond issuers.   Interest expense increased to $10.5 million for the 2002 Quarterly Period from $2.3million for the 2001 Quarterly Period primarily due to our assumption of COR's convertible notes.

        We sold our equity interest in Millennium & ILEX Partners, L.P. ("M&I") and in consideration for the sale, we received aninitial payment of $20.0 million in December 2001.  During the 2002 Quarterly Period, we recorded an additional gain of $40.0 millionpayable in December 2002 on our sale of this equity interest based upon the achievement of a predetermined sales target of CAMPATH®(alemtuzumab) humanized monoclonal antibody for 2002 that entitles us to receive this additional payment under the terms of ouragreement with ILEX.

17

        During the 2002 Quarterly Period, we recorded a non-cash charge of $54.0 million relating to the fair value of the premium putplaced on COR's convertible notes that were assumed in the merger.  See *Acquisitions—COR* for further discussion of the putoptions.

**Six Months Ended June 30, 2002 and June 30, 2001**

        For the six months ended June 30, 2002 (the "2002 Six Month Period"), we reported a net loss of $411.6 million or $1.53 perbasic and diluted share as compared to a net loss of $99.8 million or $0.46 per basic and diluted share for the six months ended June30, 2001 (the "2001 Six Month Period").

        Revenues increased to $160.5 million for the 2002 Six Month Period from $109.4 million for the 2001 Six Month Period.  Theincrease is attributable to our share of profits from INTEGRILIN® (eptifibatide) Injection copromoted by us and Schering.Also included in product revenue are reimbursements of certain manufacturing-related expenses and royalties from Schering on sales ofINTEGRILIN outside the copromotion territory.  Revenue under strategic alliances decreased due to the termination of certain of ourearly strategic alliances, offset by increased milestone revenue from the Bayer alliance.  We expect that our revenue mix willcontinue this shift as we develop our pipeline and evolve our partnerships.

        Included in revenue for the six month periods presented in 2002 and 2001 is $22.1 million and $22.3 million, respectively, ofrevenue that was recognized in prior years relating to the adoption of SAB 101.

        Research and development expenses increased to $223.7 million in the 2002 Six Month Period from $187.1 million for the 2001Six Month Period.  The increase was primarily attributable to our continued investment in building a sustainable product pipeline,with increases in personnel and facilities, expenses relating to clinical trials and preclinical product candidates, and consulting.

        Selling, general and administrative expenses increased to $77.3 million for the 2002 Six Month Period from $35.6 million forthe 2001 Six Month Period. This increase represents expenses from our commercial organization that were not present last year as well as increased expenses due to the expansion of our business groups,facilities and infrastructure necessary to support the development of our pipeline and growth in all areas of our business.Significant increases were primarily in personnel expenses, consulting and facility expenses.

        Cost of product revenue consists of certain manufacturing-related and advertising and promotional expenses associated with thesale of INTEGRILIN within copromotion territories.  Cost of product revenue fluctuates in relation to the domestic sales ofINTEGRILIN and as we incur more or less of the joint activities that we undertake in our collaboration with Schering.

        On February 12, 2002, we acquired COR for an aggregate purchase price of $1.8 billion primarily consisting of 55.1 millionshares of Millennium common stock pursuant to the merger agreement between Millennium and COR. This calculation is based on CORoutstanding common stock at February 12, 2002 using the conversion ratio of 0.9873 of a share of Millennium common stock for eachshare of outstanding COR common stock. In addition, options to purchase approximately 6.2 million shares of COR common stock with aweighted average exercise price of $12.90 were assumed by us pursuant to the merger and converted into options to purchaseapproximately 6.1 million shares of Millennium common stock with a weighted average exercise price of $13.07.

        The transaction was recorded as a purchase for accounting purposes and the consolidated financial statements include COR'soperating results from the date of the acquisition. The purchase price was allocated to the assets purchased and the liabilitiesassumed based upon their respective fair values, with the excess of the purchase price over the estimated fair value of net tangibleassets allocated to specific intangible assets and goodwill.

        We also recorded a one-time, non-cash charge to operations in the 2002 Six Month Period of $242.0 million for acquiredin-process research and development. The valuation of acquired in-process research and development represents the estimated fairvalue related to incomplete projects that, at the time of the COR acquisition, had no alternative future use and for whichtechnological feasibility had not been established.

18

        The income approach was used to establish the fair values of developed technology, trademark and acquired in-process researchand development. This approach establishes the fair value of an asset by estimating the after-tax cash flows attributable to theasset over its useful life and then discounting these after-tax cash flows back to a present value. The discounting process uses arate of return commensurate with the time value of money and investment risk factors. Accordingly, for the purpose of establishingthe fair value of developed technology, trademark and acquired in-process research and development, revenues for each future periodwere estimated, along with costs, expenses, taxes and other charges. Revenue estimates were based on estimates of relevant marketsizes and growth factors, expected trends in technology and the nature and expected timing of new product introductions by us and ourcompetitors.

        The in-process technology we acquired from COR consisted of five significant research and development projects with valuesassigned of $4.0 million to $149.0 million for each project. These projects include the development of pipeline products for the treatment ofcardiovascular diseases, including acute myocardial infarction, restenosis, cirrhosis, pulmonary fibrosis, venous thrombosis, andstroke prevention, as well as in the area of oncology.  Through the acquisition date, COR had spent approximately $80.0 million to$140.0 million on each of these five in-process research and development projects.  We expect to incur an additional $86.0 million to$146.0 million of development expenses for each of these five significant projects.  The five projects acquired, which are in variousstages of preclinical and Phase II clinical trials, are expected to reach completion in 2003 through 2009.

        A major risk associated with the timely completion and commercialization of these products is the ability to confirm the safetyand efficacy of the technology based on the data of long-term clinical trials.  If these projects are not successfully developed,future results of operations may be adversely affected.  Additionally, the value of the other intangible assets acquired may becomeimpaired.

        We believe that the assumptions used to value the acquired intangibles and in-process research and development were reasonableat the time of the acquisition.  No assurance can be given, however, that the underlying assumptions used to estimate expectedproject revenues, development costs or profitability, or the events associated with such projects, will transpire as estimated.  Forthese reasons, among others, actual results may vary from the projected results.

        Amortization of intangible assets in the 2002 Six Month Period relates to specifically identified intangible assets from theCOR, LeukoSite and CDC acquisitions.  Amortization of intangible assets in the 2001 Six Month Period relates to existing technology,assembled workforce and goodwill acquired through the acquisitions of LeukoSite and CDC. Amortization expense decreased to$15.3 million in the 2002 Six Month Period from $32.3 million in the 2001 Six Month Period due to the adoption of SFAS No. 142,"Goodwill and Intangible Assets."  Following our adoption of SFAS 142 effective as of January 1, 2002, we continue to amortizespecifically identifiable intangible assets and ceased amortizing goodwill and assembled workforce which was reclassified togoodwill.

        Investment income increased to $60.1 million for the 2002 Six Month Period from $54.5 million for the 2001 Six Month Perioddue to an increase in our average balance of cash, cash equivalents and marketable securities. We recorded realized losses of $17.1million during the 2002 Six Month Period, including a $14.6 million write-down relating to certain bond investments.   Interestexpense increased to $17.2 million for the 2002 Six Month Period from $4.7 million for the 2001 Six Month Period primarily due to ourassumption of COR's convertible notes.

        We sold our equity interest in M&I and in consideration for the sale, we received an initial payment of $20.0 million inDecember 2001.  During the 2002 Six Month Period, we recorded an additional gain of $40.0 million payable in December 2002 on oursale of this equity interest based upon the achievement of a predetermined sales target of CAMPATH® (alemtuzumab) humanizedmonoclonal antibody for 2002 that entitles us to receive this additional payment under the terms of our agreement with ILEX.

        During the 2002 Six Month Period, we recorded a non-cash charge of $54.0 million relating to the fair value of the premium putplaced on COR's convertible notes that were assumed in the merger.   See *Acquisitions—COR* for further discussion of the putoptions.

19

        During the 2001 Six Month Period, we paid an aggregate of $2.6 million in cash to certain holders of the 5.5% notes in order toinduce the conversion of their notes into our common stock.

**Liquidity and Capital Resources**

        We require cash to fund our operating expenses, to make capital expenditures, acquisitions and investments and to pay debtservice, including principal and interest and capital lease payments. As described above under "Overview—Expansion of Operations," weexpect that our cash requirements for all of these uses will increase as the scale of our operations grows.

        Historically, we have funded our cash requirements primarily through the following:
 • payments from our strategic collaborators including license fees, milestone payments and researchfunding;     • equity investments by our strategic collaborators, including:      • $28.6 million from Abbott in both March and June 2002 and $50.0 million in April 2001; • $50.0 million from Aventis in January 2001;     • equity and debt financings, including:     • our October 2000 secondary public common stock offering; • our January 2000 issuance of the 5.5% notes;     • property and equipment financings; and     • net cash acquired of $309.1 million in connection with the COR acquisition.
        We expect to continue to fund our cash requirements from these external sources in the future. In particular, we are entitledto additional committed research and development funding under a number of our strategic alliances, Abbott has agreed to purchase anadditional $85.6 million of our common stock in three quarterly installments through 2003 and we may receive additional substantialpayments from ILEX as a result of our sale of our joint venture interest in M&I. In addition, we anticipate that product revenuerelating to sales of INTEGRILIN® (eptifibatide) Injection in the U.S. will result in significant internally generated funds.

        We believe that the key factors that could affect our internal and external sources of cash are:
 •  revenues and margins from sales of INTEGRILIN and other products and services for which weobtain marketing approval in the future;     • the success of our clinical and preclinical development programs;     • the receptivity of the capital markets to financings by biopharmaceutical companies;     • our ability to enter into additional strategic collaborations and to maintain existing and newcollaborations and the success of such collaborations; and     • the sales levels of CAMPATH® (alemtuzumab) humanized monoclonal antibody.
        As of June 30, 2002 and December 31, 2001, we had approximately $1.9 billion and $1.5 billion, respectively in cash, cashequivalents and marketable securities. This excludes $38.9 million of interest-bearing marketable securities classified as restrictedcash on our balance sheet as of June 30, 2002, which serve as collateral for letters of credit securing leased facilities.

20

        During the six months ended June 30, 2001, we paid $2.6 million in cash to certain holders of the 5.5% notes in order to inducethe conversion of $12.6 million of these notes into approximately 0.3 million shares of Millennium common stock.   These cashpayments were expensed during the six months ended June 30, 2001.  Interest accrued through the date of conversion was charged tointerest expense and was paid upon conversion.  At June 30, 2002, we had $83.3 million of outstanding 5.5% notes.

        During the six months ended June 30, 2002, we received $57.2 million from Abbott for a purchase of approximately 2.8 millionshares of our common stock under an equity investment agreement.   During the six months ended June 30, 2001, we received $50.0million from each of Aventis and Abbott for purchases of approximately 0.8 million and 1.6 million shares, respectively of our commonstock under equity investment agreements.

*Cash Flows*

        We used $173.3 million of cash in operating activities in the 2002 Six Month Period and $68.2 million in the 2001 Six MonthPeriod. The principal use of cash in operating activities in both 2002 and 2001 was to fund our net loss.

        In addition to operating expenses we incur as a result of our alliances with our strategic partners, we have also madecommitments to purchase debt and/or equity securities from certain of these partners.

        Investing activities provided net cash of $135.2 million in the 2002 Six Month Period. We used cash of $82.5 million ininvesting activities in the 2001 Six Month Period.  The principal source of funds in the 2002 Six Month Period is from the cashacquired in the COR acquisition.  The principal uses in the 2002 and 2001 Six Month Periods were purchases of investments inmarketable securities, property and equipment and other long term assets.

        Financing activities provided net cash of $56.4 million in the 2002 Six Month Period and $105.2 million in the 2001 Six MonthPeriod. The principal source of net cash from financing activities in the 2002 Period was the sales of common stock to Abbott and inthe 2001 Period was the sale of common stock to Abbott and Aventis.

*Contractual obligations*

        Our major outstanding contractual obligations relate to our convertible notes, our capital leases from equipment financingsand our facilities leases. Our facilities lease expense in future years will increase significantly over past years as a result ofnew lease arrangements entered into in 2000 and 2001 described below and the facilities leases assumed by us in the COR acquisition.

        Our convertible notes aggregate $683.3 million in principal amount outstanding. These notes consist of $83.3 million of the5.5% notes, $300.0 million of the 4.5% notes assumed by us in the COR acquisition and $300.0 million of the 5.0% notes assumed by usin the COR acquisition. All three issues of notes require semi-annual interest payments through maturity.  On March 14, 2002, we, asrequired by the terms of the notes assumed by us in the COR acquisition, commenced cash repurchase offers to the noteholders inamounts equal to 100% of the principal amounts of the notes plus interest accrued and unpaid through April 28, 2002.

        On April 22, 2002 we amended the terms of the 5.0% notes and 4.5% notes to induce noteholders to hold such notes until atleast April 29, 2003.  Specifically, we amended the 4.5% notes to permit noteholders to exchange these notes for cash at a price of$1,095 per $1,000 of principal amount on April 29, 2003 and we amended the 5.0% notes to permit noteholders to exchange these notesfor cash at a price of $1,085 per $1,000 of principal amount on April 29, 2003.

        On April 29, 2002, our cash repurchase offers to the noteholders of the outstanding 4.5% notes and 5.0% notes expired.  As ofthe expiration, $40,000 of these notes were tendered and repurchased by us for cash.

        In February 2001, we entered into a lease agreement relating to a building to be constructed for laboratory and office space inCambridge, England. The lease has a term of 20 years and is expected to commence in 2003

21

upon completion of construction. We are responsible for a portion of the construction costs, which we estimate to be approximately $21.0 million. Rent is expected to beapproximately $2.6 million per year based upon foreign currency exchange rates at June 30, 2002 and is subject to market adjustmentsat the end of the 5th, 10th and 15th years.

        We also have lease obligations relating to two buildings to be constructed for laboratory and office space in Cambridge,Massachusetts. The rent obligation for the first of these buildings began in July 2002.  The rent obligation for the second buildingis expected to commence on the earlier of (a) October 1, 2003 or (b) the date on which we commence occupancy of the building. Eachlease is for a term of seventeen years. We are responsible for a portion of the construction costs for both buildings. Our cost tocomplete each of the buildings is expected to be approximately $37.9 and $42.0 million, respectively. Rent is calculated on anescalating scale ranging from approximately $7.6 million, per building per year, to approximately $9.7 million, per building peryear.

        There have been no other significant changes to our contractual obligations and commercial commitments since we presented thoseamounts in our Form 10-K as of December 31, 2001, except for Amendment No. 6 dated as of March 22, 2002 to Agreement dated as ofSeptember 22, 1998 by and between Bayer AG and us filed as an exhibit to our Form 10-Q for the period ended March 31, 2002.

        We believe that existing cash and cash equivalents, internally generated funds and the anticipated cash payments from ourcurrent strategic alliances will be sufficient to support our operations and fund our capital commitments for the near term. Ouractual future cash requirements, however, will depend on many factors, including:
 • the progress of our disease research programs; • the number and breadth of these programs; • achievement of milestones under strategic alliance arrangements; • our ability to establish and maintain additional strategic alliance and licensing arrangements; • success of INTEGRILIN® (eptifibatide) Injection and additional products introduced into the market; • the sales levels of CAMPATH® (alemtuzumab) humanized monoclonal antibody; and • the progress of our development efforts and the development efforts of our strategic partners.
**CERTIFICATIONS OF OFFICERS**

        Our Chief Executive Officer and Chief Financial Officer have certified that they have reviewed: (i) our Annual Report on Form10-K for the fiscal year ended December 31, 2001 filed with the Securities and Exchange Commission; (ii) all reports on Form 10-Q,all reports on Form 8-K and all definitive proxy materials filed by us with the Securities and Exchange Commission subsequent to thefiling of the Form 10-K identified above; and (iii) any amendments to these filings.  These officers have also certified that, to thebest of their knowledge, none of the above reports contained an untrue statement of a material fact as of the end of the periodcovered by such report (or in the case of a report on Form 8-K or definitive proxy materials, as of the date on which it was filed);and no report omitted to state a material fact necessary to make the statements in the report, in light of the circumstances underwhich they were made, not misleading as of the end of the period covered by such report (or in the case of a report on Form 8-K ordefinitive proxy materials, as of the date on which it was filed).  These officers have reviewed their certifications with our AuditCommittee.

**RISK FACTORS THAT MAY AFFECT RESULTS**

        This Quarterly Report on Form 10-Q and certain other communications made by us contain forward-looking statements, includingstatements about our growth and future operating results, discovery and development of products, potential acquisitions, strategicalliances and intellectual property. For this purpose, any statement that is not a statement of historical fact should be considereda forward-looking statement. We often use the words "believes," "anticipates," "plans," "expects," "intends" and similar expressionsto help identify forward-looking statements.

22

        There are a number of important factors that could cause our actual results to differ materially from those indicated orimplied by forward-looking statements. Factors that could cause or contribute to such differences include those discussed below, aswell as those discussed elsewhere in this Form 10-Q. We disclaim any intention or obligation to update or revise any forward-lookingstatements, whether as a result of new information, future events or otherwise.

**Risks Relating to COR Acquisition**

**We may face challenges in integrating COR and, as a result, may not realize the expected benefits of the merger.**

        We closed the acquisition of COR on February 12, 2002. Integrating the operations and personnel of COR with our otheroperations and personnel is a complex process. We are uncertain that the integration will be completed rapidly or that we willachieve the anticipated benefits of the merger. The successful integration of COR will require, among other things, coordination ofdiscovery and development efforts and integration of COR's administration and sales and marketing groups into our existing groups.The inability to successfully integrate the operations and personnel of COR or any significant delays in achieving integration couldhave a material adverse effect on our business.

**As a result of our merger with COR, we are a substantially larger and broader organization; if our senior executive team is unable tosuccessfully manage the combined company, our operating results will suffer.**

        As a result of our acquisition of COR, we face challenges inherent in efficiently managing an increased number of employeesover large geographic distances, including the need to develop appropriate systems, policies, benefits and compliance programs. Inaddition, COR has focused on developing products for treating and preventing cardiovascular diseases, while we have targetedoncology, inflammatory disease and metabolic disease. We will need to manage the allocation of our resources to this additional focusarea, which includes the FDA approved drug INTEGRILIN® (eptifibatide) Injection. In the event we do not effectively manage theallocation of resources among our programs, sales of INTEGRILIN or our ability to successfully develop our other existing productcandidates into revenue generating products could be materially adversely affected.

**The merger could cause us to lose key COR personnel and require us to incur substantial costs to recruit replacements for lostpersonnel.**

         As a result of our acquisition of COR, former COR employees could experience uncertainty about their future roles within ourcompany. This uncertainty may adversely affect our ability to retain key COR management, sales, marketing and technical personnel.Any failure to retain key personnel could have a material adverse effect on our business.

**Regulatory Risks**

**We may not be able to obtain marketing approval for products or services resulting from our development efforts or to marketINTEGRILIN for additional therapeutic uses.**

        All of the products that we are developing will require additional research and development, extensive preclinical studiesand clinical trials and regulatory approval prior to any commercial sales. This process is lengthy, often taking a number of years,and expensive. In some cases, the length of time that it takes for us to achieve various regulatory approval milestones affects thepayments that we are eligible to receive under our strategic alliance agreements. For example, a payment is due to us from Scheringif INTEGRILIN receives an expanded marketing authorization for the European Union.

        We may need to successfully address a number of technological challenges in order to complete development of our products.Moreover, these products may not be effective in treating any disease or may prove to have undesirable or unintended side effects,toxicities or other characteristics that may preclude our obtaining regulatory approval or prevent or limit commercial use.

23

        INTEGRILIN® (eptifibatide) Injection has been approved for a specific set of therapeutic uses. To grow our business, we mayneed to obtain regulatory approval to be able to promote INTEGRILIN for additional therapeutic uses.

**If we fail to comply with regulatory requirements, or if we experience unanticipated problems with our approved products, ourproducts could be subject to restrictions or withdrawal from the market.**

        Any product for which we obtain marketing approval, along with the manufacturing processes, post-approval clinical data andpromotional activities for such product, will be subject to continual review and periodic inspections by the FDA and other regulatorybodies. Later discovery of previously unknown problems with our products or manufacturing processes, or failure to comply withregulatory requirements, may result in restrictions on such products or manufacturing processes, withdrawal of the products from themarket or the imposition of civil or criminal penalties.

**We have only limited experience in regulatory affairs, and some of our products may be based on new technologies; these factors mayaffect our ability or the time we require to obtain necessary regulatory approvals.**

        We have only limited experience in filing and prosecuting the applications necessary to gain regulatory approvals. Moreover,certain of the products that are likely to result from our research and development programs may be based on new technologies and newtherapeutic approaches that have not been extensively tested in humans. The regulatory requirements governing these types of productsmay be more rigorous than for conventional products. As a result, we may experience a longer regulatory process in connection withany products that we develop based on these new technologies or new therapeutic approaches.

**Risks Relating to Our Business, Strategy and Industry**

**Our revenues over the next several years will be materially dependent on the commercial success of INTEGRILIN.**

        Our revenues over the next several years will be materially dependent on the commercial success of INTEGRILIN, which hasbeen on the market in the United States since June 1998. Marketing outside the United States commenced in mid-1999. Although sales ofINTEGRILIN have increased since its launch, if sales do not continue to increase over current levels, we will not achieve ourbusiness plan and may be forced to scale back our operations and research and development programs.

**Sales of INTEGRILIN in particular reporting periods may be affected by fluctuations in buying patterns.**

        A significant portion of INTEGRILIN domestic pharmaceutical sales is made to major drug wholesalers. These sales areaffected by fluctuations in the buying patterns of these wholesalers and the corresponding changes in inventory levels maintained bythem. These changes may not reflect underlying prescriber demand.  Additionally, we expect that sales from INTEGRILIN will generallybe lower in the summer months because fewer medical procedures are typically performed during these months.  These fluctuations insales of INTEGRILIN may have a material adverse effect on our results of operations for particular reporting periods.

**Because discovering drugs based upon genomics is new, it is possible that this discovery process will not result in commercialproducts or services.**

        The process of discovering drugs based upon genomics is new and evolving rapidly. We focus our genomics research primarilyon diseases that may be linked to several or many genes working in combination. Both we and the general scientific and medicalcommunities have only a limited understanding relating to the role of genes and their products in these diseases. To date, we havenot commercialized any products discovered through our genomics research, and we may not be successful in doing so in the future. Inaddition, relatively few products based on gene discoveries have been developed and commercialized by others. Rapid technologicaldevelopment by us or others may result in compounds, products or processes becoming obsolete before we recover our developmentexpenses.

24

**We face substantial competition, particularly in the cardiovascular disease market, which may result in others discovering,developing or commercializing products and services before or more successfully than us.**

        The fields of genomics, biotechnology and pharmaceuticals are highly competitive. Many of our competitors are substantiallylarger than us and have substantially greater capital resources, research and development staffs and facilities than us. Furthermore,many of our competitors are more experienced than us in drug discovery, development and commercialization, obtaining regulatoryapprovals and product manufacturing and marketing. As a result, our competitors may identify genes associated with diseases ordiscover, develop and commercialize pharmaceutical products or services before us. In addition, our competitors may discover, developand commercialize products or services that render non-competitive or obsolete the products or services that we or our collaboratorsare seeking to develop and commercialize.

        In particular due to the incidence and severity of cardiovascular diseases, the market for therapeutic products that addressthese diseases is large, and competition is intense and expected to increase. Our most significant competitors are majorpharmaceutical companies and more established biotechnology companies. The two products that compete with INTEGRILIN® (eptifibatide)Injection are ReoPro®, which is produced by Johnson & Johnson and sold by Johnson & Johnson and Eli Lilly and Company, and Aggrastat®,which is produced and sold by Merck & Co., Inc. These competitors operate large, well-funded cardiovascular research and developmentprograms and have significant expertise in manufacturing, testing, regulatory matters and marketing.

**If our clinical trials are unsuccessful, or if they experience significant delays, our ability to commercialize products will beimpaired.**

        We must provide the FDA and foreign regulatory authorities with preclinical and clinical data that demonstrate that ourproducts are safe and effective before they can be approved for commercial sale. Clinical development, including preclinical testing,is a long, expensive and uncertain process. It may take us several years to complete our testing, and failure can occur at any stageof testing. Interim results of preclinical or clinical studies do not necessarily predict their final results, and acceptable resultsin early studies might not be seen in later studies. Any preclinical or clinical test may fail to produce results satisfactory to theFDA. Preclinical and clinical data can be interpreted in different ways, which could delay, limit or prevent regulatory approval.Negative or inconclusive results from a preclinical study or clinical trial or adverse medical events during a clinical trial couldcause a preclinical study or clinical trial to be repeated or a program to be terminated, even if other studies or trials relating tothe program are successful.

        We may not complete our planned preclinical or clinical trials on schedule or at all. In addition, due to the substantialdemand for clinical trial sites in the cardiovascular area, we may have difficulty obtaining a sufficient number of appropriatepatients or clinician support to conduct our clinical trials as planned. If so, we may have to expend substantial additional funds toobtain access to resources or delay or modify our plans significantly. Our product development costs will increase if we experiencedelays in testing or approvals. Significant clinical trial delays could allow our competitors to bring products to market before wedo and impair our ability to commercialize our products or potential products.

**We may not be able to obtain biological material, including human and animal DNA samples, required for our genetic studies, whichcould delay or impede our drug discovery efforts.**

        Our gene identification strategy includes genetic studies of families and populations prone to particular diseases. Thesestudies require the collection of large numbers of DNA samples from affected individuals, their families and other suitablepopulations as well as animal models. The availability of DNA samples and other biological material is important to our ability todiscover the genes responsible for human diseases through human genetic approaches and other studies. Competition for these resourcesis intense. Access to suitable populations, materials and samples could be limited by forces beyond our control, includinggovernmental actions. Some of our competitors may have obtained access to significantly more family and population resources andbiological materials than we have obtained. As a result, we may not be able to obtain access to DNA samples necessary to support ourhuman gene discovery programs.

25

**Because many of the products and services that we develop will be based on new technologies and therapeutic approaches, the marketmay not be receptive to these products and services upon their introduction.**

        The commercial success of any of our products and services for which we may obtain marketing approval from the FDA or otherregulatory authorities will depend upon their acceptance by the medical community and third party payors as clinically useful,cost-effective and safe. Many of the products and services that we are developing are based upon new technologies or therapeuticapproaches. As a result, it may be more difficult for us to achieve market acceptance of our products and services, particularly thefirst products and services that we introduce to the market based on new technologies and therapeutic approaches. Our efforts toeducate the medical community on these potentially unique approaches may require greater resources than would be typically requiredfor products and services based on conventional technologies or therapeutic approaches. The safety, efficacy, convenience andcost-effectiveness of our products as compared to competitive products will also affect market acceptance.

**Risks Relating to Our Financial Results and Need for Financing**

**We have incurred substantial losses and expect to continue to incur losses. We will not be successful unless we reverse this trend.**

        We have incurred losses in all but two of the years since our inception. We expect to continue to incur substantialoperating losses in future periods. Prior to our acquisition of COR, substantially all of our revenues resulted from payments fromcollaborators, and not from the sale of products.

        We expect to increase our spending significantly as we continue to expand our infrastructure, research and developmentprograms and commercialization activities. As a result, we will need to generate significant revenues to pay these costs and achieveprofitability. We cannot be certain whether or when we will become profitable because of the significant uncertainties with respectto our ability to generate revenues from the sale of products and services and from existing and potential future strategic alliances.

**We may need additional financing, which may be difficult to obtain. Our failure to obtain necessary financing or doing so onunattractive terms could adversely affect our discovery and development programs and other operations.**

        We will require substantial funds to conduct research and development, including preclinical testing and clinical trials ofour potential products. We will also require substantial funds to meet our obligations to our collaborators and maximize theprospective benefits to us from our alliances, manufacture and market products and services that are approved for commercial sale,including INTEGRILIN® (eptifibatide) Injection, and meet our debt service obligations. Additional financing may not be available whenwe need it or may not be available on favorable terms.

        If we are unable to obtain adequate funding on a timely basis, we may be required to significantly curtail one or more ofour discovery or development programs. We could be required to seek funds through arrangements with collaborators or others that mayrequire us to relinquish rights to certain of our technologies, product candidates or products which we would otherwise pursue on ourown.

**Our indebtedness and debt service obligations may adversely affect our cash flow.**

        At June 30, 2002 we had approximately $683.3 million of outstanding debt. During each of the last five years, our earningswere insufficient to cover our fixed charges. During each of the next three years, we will be required to make interest payments onour outstanding convertible notes totaling approximately $33.1 million. In addition, we recently amended the convertible notesassumed upon our acquisition of COR to provide noteholders the right to put these notes to us, on April 29, 2003, for cash at apremium to face value. The aggregate amount of this premium on the $600.0 million principal amount of these notes is approximately$54.0 million. In the event that the holders of large numbers of these notes put these notes to us, the amount of our cash would besubstantially diminished.  If we are unable to generate sufficient cash to meet these obligations

26

and have to use existing cash or investments, we may have to delay or curtail our research and development programs.

        We intend to fulfill our debt service obligations both from cash generated by our operations and from our existing cash andinvestments. We may add additional lease lines to finance capital expenditures and may obtain additional long-term debt and lines ofcredit.

        Our indebtedness could have significant additional negative consequences, including:
 • increasing our vulnerability to general adverse economic and industry conditions;     • limiting our ability to obtain additional financing;     • requiring the dedication of a substantial portion of our expected cash flow from operations toservice our indebtedness, thereby reducing the amount of our expected cash flow available forother purposes, including capital expenditures;     • limiting our flexibility in planning for, or reacting to, changes in our business and the industry inwhich we compete; and     • placing us at a possible competitive disadvantage to less leveraged competitors and competitorsthat have better access to capital resources.    
**We have sold our interest in CAMPATH®; as a result, we will no longer have control over the financial success of that product.**

        On December 31, 2001, ILEX Oncology, Inc. acquired our equity interest in Millennium & ILEX Partners, L.P., which owns theCAMPATH product. In exchange for our equity interest in Millennium & ILEX Partners, ILEX paid us $20 million on December 31, 2001 andis obligated to pay us up to an additional $120.0 million over the next three years if sales of CAMPATH in the U.S. meet specifiedsales thresholds. In addition, we will be entitled to additional payments from ILEX based on U.S. sales of CAMPATH after 2004. Therecan be no assurance that we will receive any of the payments that are dependent on sales of CAMPATH. In addition, we will have noability to influence the actions of the entity that owns CAMPATH and, therefore, will have no control over the financial success ofCAMPATH.

**Risks Relating to Collaborators**

**We depend significantly on our collaborators to develop and commercialize products and services based on our work. Our business maysuffer if any of our collaborators breaches its agreement or fails to support or terminates its alliance with us.**

        We conduct most of our discovery and development activities through strategic alliances and market and sell INTEGRILIN®(eptifibatide) Injection through an alliance with Schering. The success of our alliances depends heavily on the efforts andactivities of our collaborators. Each of our collaborators has significant discretion in determining the efforts and resources thatthey will apply to the alliance. Our existing and any future alliances may not be scientifically or commercially successful.

        The risks that we face in connection with these alliances include:
 • all of our strategic alliance agreements are subject to termination under various circumstances,including, in many cases, on short notice without cause;     • in our strategic alliance agreements, we generally agree not to conduct specified types ofresearch and development in the field that is the subject of the alliance. These agreements mayhavethe effect of limiting the areas of research and development we may pursue, either alone orin collaboration with third parties;    
27
 • our collaborators may develop and commercialize, either alone or with others, products andservices that are similar to or competitive with the products and services that are the subject ofthe alliance with us;     • our collaborators may change the focus of their development and commercialization efforts.Pharmaceutical and biotechnology companies historically have re-evaluated their prioritiesfollowingmergers and consolidations, which have been common in recent years in theseindustries; and     • we will rely on our collaborators to manufacture most products covered by our alliances. Forexample, Schering is one of the manufacturers of INTEGRILIN® (eptifibatide) Injection andBecton Dickinson has the soleright to develop, manufacture and commercialize our Melastatin®gene detection product.    
**We may not be successful in establishing additional strategic alliances, which could adversely affect our ability to develop andcommercialize products and services.**

        An important element of our business strategy is entering into strategic alliances for the development and commercializationof products and services based on our discoveries. We face significant competition in seeking appropriate collaborators. Moreover,these alliance arrangements are complex to negotiate and time-consuming to document. We may not be successful in our efforts toestablish additional strategic alliances or other alternative arrangements. The terms of any additional strategic alliances or otherarrangements that we establish may not be favorable to us. Moreover, such strategic alliances or other arrangements may not besuccessful.

**Risks Relating to Intellectual Property**

**If we are unable to obtain patent protection for our discoveries, the value of our technology and products will be adverselyaffected. If we infringe patent or other intellectual property rights of third parties, we may not be able to develop andcommercialize our products and services or the cost of doing so may increase.**

        Our patent positions, and those of other pharmaceutical and biotechnology companies, are generally uncertain and involvecomplex legal, scientific and factual questions.

        Our ability to develop and commercialize products and services depends in significant part on our ability to:
 • obtain patents;     • obtain licenses to the proprietary rights of others on commercially reasonable terms;     • operate without infringing upon the proprietary rights of others;     • prevent others from infringing on our proprietary rights; and     • protect trade secrets.    
**There is significant uncertainty about the validity and permissible scope of patents in our industry, which may make it difficult forus to obtain patent protection for our discoveries.**

        The validity and permissible scope of patent claims in the pharmaceutical and biotechnology fields, including the genomicsfield, involve important unresolved legal principles and are the subject of public policy debate in the United States and abroad. Forexample, there is significant uncertainty both in the United States and abroad regarding the patentability of gene sequences in theabsence of functional data and the scope of patent protection available for full-length genes and partial gene sequences. Moreover,some groups have made

28

particular gene sequences available in publicly accessible databases. These and other disclosures may adverselyaffect our ability to obtain patent protection for gene sequences claimed by us in patent applications that we file subsequent tosuch disclosures. There is also some uncertainty as to whether human clinical data will be required for issuance of patents for humantherapeutics. If such data are required, our ability to obtain patent protection could be delayed or otherwise adversely affected.

**Third parties may own or control patents or patent applications and require us to seek licenses, which could increase our developmentand commercialization costs, or prevent us from developing or marketing our products or services.**

        We may not have rights under some patents or patent applications related to our proposed products, processes or services.Third parties may own or control these patents and patent applications in the United States and abroad. Therefore, in some cases,such as those described below, to develop, manufacture, sell or import certain of our proposed products, processes or services, we orour collaborators may choose to seek, or be required to seek, licenses under third party patents issued in the United States andabroad or those that might issue from United States and foreign patent applications. In such event, we would be required to paylicense fees or royalties or both to the licensor. If licenses are not available to us on acceptable terms, we or our collaboratorsmay not be able to develop, manufacture, sell or import these products, processes or services.

        With respect to our product candidate MLN01, we are aware of third party patents and patent applications which relate tocertain anti-CD18 antibodies and their use in various methods of treatment including methods of reperfusion therapy and methods oftreating focal ischemic stroke. In addition, our MLN01 and MLN02 product candidates are humanized monoclonal antibodies. We are awareof third party patents and patent applications that relate to certain humanized or modified antibodies, products useful for makinghumanized or modified antibodies and processes for making and using humanized or modified antibodies. We are also aware of thirdparty patents and patent applications relating to certain manufacturing processes, products thereof and materials useful in suchprocesses. We are also aware of third party patent applications and a potentially interfering patent application relating toanti-PSMA antibodies.

        Our product candidates VELCADETM (bortezomib) for Injection (formerly known as MLN341, LDP-341 and PS-341) and MLN519 aresmall molecule drug candidates. For the use of VELCADE and MLN519in the treatment of infarctions, we are aware of the existence of a potentially interfering patent application filed by one of ourformer consultants. We are also aware of third party patents relating to assays relating to the NFkB pathway.

        On June 26, 2002, Ariad Pharmaceuticals, Inc. sent us and approximately 50 other parties a letter offering a sublicense forthe use of U.S. Patent No. 6,410,516 (which was recently issued and which is exclusively licensed to Ariad).  We have seriousquestions concerning the validity of this patent.  However, if Ariad sued us for infringement of this patent, and the patent wasfound to be valid and we were found to be infringing, we could be required to pay royalties based on the U.S. sales of VELCADE, whichwould reduce our profits on these sales and which could have a material adverse effect on our business.

**We may become involved in expensive patent litigation or other proceedings, which could result in our incurring substantial costs andexpenses or substantial liability for damages or require us to stop our development and commercialization efforts.**

        There has been substantial litigation and other proceedings regarding the patent and other intellectual property rights inthe pharmaceutical and biotechnology industries. We may become a party to patent litigation or other proceedings regardingintellectual property rights. For example, we believe that we hold patent applications that cover genes that are also claimed inpatent applications filed by others. Interference proceedings before the United States Patent and Trademark Office may be necessaryto establish which party was the first to invent these genes.

        The cost to us of any patent litigation or other proceeding, even if resolved in our favor, could be substantial. Some ofour competitors may be able to sustain the cost of such litigation or proceedings more effectively than we can because of theirsubstantially greater financial resources. If a patent litigation or other

29

proceeding is resolved against us, we or our collaboratorsmay be enjoined from developing, manufacturing, selling or importing our products, processes or services without a license from theother party and we may be held liable for significant damages. We may not be able to obtain any required license on commerciallyacceptable terms or at all.

        Uncertainties resulting from the initiation and continuation of patent litigation or other proceedings could have a materialadverse effect on our ability to compete in the marketplace. Patent litigation and other proceedings may also absorb significantmanagement time.

**Risks Relating to Product Manufacturing, Marketing and Sales**

**Because we have limited sales, marketing and distribution experience and capabilities, we may be dependent on third parties tosuccessfully perform these functions on our behalf or may be required to incur significant costs and devote significant efforts toaugment our existing capabilities.**

        We have limited sales, marketing and distribution experience and capabilities, primarily the specialty sales force that weacquired in the COR merger that markets INTEGRILIN® (eptifibatide) Injection. Depending on the nature of the products and servicesfor which we obtain market approval, we may need to rely significantly on sales, marketing and distribution arrangements with ourcollaborators and other third parties. For example, some types of pharmaceutical products require a large sales force and extensivemarketing capabilities for effective commercialization. If in the future we elect to perform sales, marketing and distributionfunctions for such types of products ourselves, we would face a number of additional risks, including the need to recruit a largenumber of additional experienced marketing and sales personnel.

**Because we have limited manufacturing capabilities, we will be dependent on third-party manufacturers to manufacture products for usor will be required to incur significant costs and devote significant efforts to establish our own manufacturing facilities andcapabilities.**

        We have limited manufacturing experience and no commercial scale manufacturing capabilities. In order to continue to developproducts and services, apply for regulatory approvals and commercialize products and services, we will need to develop, contract foror otherwise arrange for the necessary manufacturing capabilities.

        We currently rely upon third parties to produce material for preclinical testing purposes and expect to continue to do so inthe future. We also expect to rely upon other third parties, including our collaborators, to produce materials required for clinicaltrials and for the commercial production of certain of our products.

        There are a limited number of manufacturers that operate under the FDA's good manufacturing practices regulations capable ofmanufacturing our products. As a result, we have experienced some difficulty finding manufacturers for our products with adequatecapacity for our anticipated future needs. If we are unable to arrange for third party manufacturing of our products, or to do so oncommercially reasonable terms, we may not be able to complete development of our products or market them.

        Reliance on third party manufacturers entails risks to which we would not be subject if we manufactured products ourselves,including reliance on the third party for regulatory compliance and quality assurance, the possibility of breach of the manufacturingagreement by the third party because of factors beyond our control and the possibility of termination or nonrenewal of the agreementby the third party, based on its own business priorities, at a time that is costly or inconvenient for us.

        We may in the future elect to manufacture certain of our products in our own manufacturing facilities. We need to investsubstantial additional funds and need to recruit qualified personnel in order to build or lease and operate any manufacturingfacilities.

30

**We face particular challenges in connection with the manufacture of INTEGRILIN® (eptifibatide) Injection; if we do not meet these challenges our revenues andincome will be adversely affected.**

        With respect to INTEGRILIN, we have two manufacturers that produce bulk product and two manufacturers, one of which isSchering at its Manati facility in Puerto Rico, that perform fill/finish and packaging. If we do not have adequate supplies ofINTEGRILIN to meet market demand, we may lose potential revenues, and the healthcare community may turn to competing products.Fill/finish and packaging of INTEGRILIN at the Schering Manati facility for sale in the United States isin abeyance pending resolution of issues to be addressed by us and Schering relating to production processes and procedures.

        Our manufacturing plans call for the addition of extra capacity for the manufacture of INTEGRILIN. If we are not able tosecure additional manufacturing capacity on favorable terms, we may not be able to expand capacity sufficiently to meet future marketdemand.

        We expect to improve or modify our existing process technologies and manufacturing capabilities for INTEGRILIN. We cannotquantify the time or expense that may ultimately be required to improve or modify our existing process technologies, but it ispossible that such time or expense could be substantial. Moreover, we may not be able to implement any of these improvements ormodifications successfully.

        Our commercialization strategy for INTEGRILIN includes establishment of multiple third-party manufacturing sources oncommercially reasonable terms. We may not be able to do so, and, even if such sources are established, they may not continue to beavailable to us on commercially reasonable terms. In the event that we are unable to obtain contract manufacturing on commerciallyacceptable terms, our ability to produce INTEGRILIN and to conduct preclinical testing and clinical trials of product candidateswould be impaired.

**If we fail to obtain an adequate level of reimbursement for our products or services by third party payors, there may be nocommercially viable markets for our products or services.**

        The availability and levels of reimbursement by governmental and other third party payors affect the market for anypharmaceutical product or healthcare service. These third party payors continually attempt to contain or reduce the costs ofhealthcare by challenging the prices charged for medical products and services. In certain foreign countries, particularly thecountries of the European Union, the pricing of prescription pharmaceuticals is subject to governmental control. We may not be ableto sell our products and services profitably if reimbursement is unavailable or limited in scope or amount.

        In particular, third party payors could lower the amount that they will reimburse hospitals to treat the conditions forwhich the FDA has approved INTEGRILIN. If they do, pricing levels or sales volumes of INTEGRILIN may decrease. In foreign markets, anumber of different governmental and private entities determine the level at which hospitals will be reimbursed for administeringINTEGRILIN to insured patients. If these levels are set, or reset, too low, it may not be possible to sell INTEGRILIN at a profit inthese markets.

        In both the United States and certain foreign jurisdictions, there have been a number of legislative and regulatoryproposals to change the healthcare system. Further proposals are likely. The potential for adoption of these proposals affects orwill affect our ability to raise capital, obtain additional collaborators and market our products.

        We expect to experience pricing pressures in connection with the sale of our future products and services due to the trendtoward managed health care, the increasing influence of health maintenance organizations and additional legislative proposals.

        Ethical, legal and social issues related to genetic testing may cause our diagnostic products to be rejected by customers orprohibited or curtailed by governmental authorities.

        Diagnostic tests that evaluate genetic predisposition to disease raise issues regarding the use and confidentiality of theinformation provided by such tests. Insurance carriers and employers might discriminate

31

on the basis of such information, resulting in a significant barrier to the acceptance of such tests by customers. This type of discrimination could cause governmentalauthorities to prohibit or limit the use of such tests.

**We face a risk of product liability claims and may not be able to obtain insurance.**

        Our business exposes us to the risk of product liability claims that is inherent in the manufacturing, testing and marketingof human therapeutic products. In particular, INTEGRILIN® (eptifibatide) Injection is administered to patients with seriouscardiovascular disease who have a high incidence of mortality. Although we have product liability and clinical trial liabilityinsurance that we believe is appropriate, this insurance is subject to deductibles and coverage limitations. We may not be able toobtain or maintain adequate protection against potential liabilities. If we are unable to obtain insurance at acceptable cost orotherwise protect against potential product liability claims, we will be exposed to significant liabilities, which may materially andadversely affect our business and financial position. These liabilities could prevent or interfere with our product commercializationefforts.

**Guidelines and recommendations can affect the use of our products.**

        Government agencies promulgate regulations and guidelines directly applicable to us and to our products. In addition,professional societies, practice management groups, private health and science foundations and organizations involved in variousdiseases from time to time may also publish guidelines or recommendations to the health care and patient communities. Recommendationsof government agencies or these other groups or organizations may relate to such matters as usage, dosage, route of administrationand use of concomitant therapies. Recommendations or guidelines that are followed by patients and health care providers could resultin decreased use of our products.

**Item 3.    Quantitative and Qualitative Disclosures About Market Risk**

        We manage our investment portfolio in accordance with our Investment Policy. The primary objectives of our Investment Policyare to preserve principal, maintain proper liquidity to meet operating needs and maximize yields. Investments are made primarily inhigh-grade corporate bonds with effective maturities of three years or less, asset-backed and U.S. government agency securities.These investments are subject to risk of default, changes in credit rating and changes in market value.  These investments are alsosubject to interest rate risk and will decrease in value if market interest rates increase. A hypothetical 100 basis point increasein interest rates would result in an approximate $27.6 million decrease in the fair value of our investments as of June 30, 2002.However, due to the conservative nature of our investments and relatively short effective maturities of debt instruments, interestrate risk is mitigated. Our Investment Policy specifies credit quality standards for our investments and limits the amount ofexposure from any single issue, issuer or type of investment.  We do not own derivative financial instruments in our investmentportfolio.

        The interest rates on our convertible subordinated notes and capital lease obligations are fixed and therefore not subject tointerest rate risk.

        Accordingly, we do not believe that there is any material market risk exposure with respect to derivative or other financialinstruments which would require disclosure under this item.

        As of June 30, 2002 we did not have any financing arrangements that were not reflected in our balance sheet.

32

**PART II OTHER INFORMATION**

**Item 2.    Changes in Securities and Use of Proceeds**

        On June 4, 2002, we issued and sold to Abbott Laboratories  1,442,274 shares of our common stock for aggregate proceeds ofapproximately $28.6 million. These shares were issued pursuant to an investment agreement dated March 9, 2001 between us and Abbott and noperson served as an underwriter with respect to this transaction.  We relied on Section 4(2) of the Securities Act of 1933, asamended (the "Securities Act") for exemption from the registration requirements of the Securities Act.

**Item 4.    Submission of Matters to a Vote of Security Holders**

        At our Annual Meeting of Stockholders held on April 25, 2002, our stockholders  elected Mark J. Levin, Shaun R. Coughlin, A.Grant Heidrich, III and Kenneth E. Weg to serve as Class III directors for a term of three years by the following votes:
 Number of SharesNameFor WithheldMark J. Levin208,638,598 1,236,554Shaun R. Coughlin208,541,005 1,334,147A. Grant Heidrich, III208,637,039 1,238,113Kenneth E. Weg208,636,526 1,238,626
        The other directors whose terms of office as a director continue after the meeting are as follows: Eugene Cordes, Ginger L. Graham,Vaughn M. Kailian, Raju S. Kucherlapati, Eric S. Lander, Ernest Mario, Edward D. Miller, Jr. and Norman C. Selby.

**Item 6.    Exhibits and Reports on Form 8-K**
(a)    Exhibits      The exhibit listed in the Exhibit Index is included in this report.  (b)    Reports on Forms 8-K
        The following Current Reports on Form 8-K were filed by us during the three months ended June 30, 2002.

        1.        A Current Report on Form 8-K filed with the Securities and Exchange Commission on April 23, 2002 to file, pursuant to Items 5 and 7, as exhibits, the Third Supplemental Indenture, dated as of April 22, 2002, betweenus and U.S. Bank, N.A. (formerly known as Firstar Bank, N.A.), relating to our 4.5% Convertible Senior Notes due June 15, 2006 and the Third Supplemental Indenture, dated as of April 22, 2002, between us and U.S. Bank,N.A. (formerly known as Firstar Bank, N.A.), relating to our 5.0% Convertible Subordinated Notes due March 1, 2007 in order to incorporate by reference those documents into our filings under the Securities Act of 1933,as amended.
        2.        A Current Report on Form 8-K was filed with the Securities and Exchange Commission on June 12, 2002 pursuant to Items 5 and 7, toreport that we issued a press release on June 11, 2002, to announce the initiation of a Phase III clinical trial ofVELCADETM (bortezomib) for Injection (formerly known as MLN341, LDP-341 and PS-341) in patients with multiple myeloma.

33

**SIGNATURES**
        Pursuant to the requirements of the Securities Exchange Act of 1934, the registrant has duly caused this report to be signed on itsbehalf by the undersigned, thereunto duly authorized.  MILLENNIUM PHARMACEUTICALS, INC.(Registrant)        Dated: August 13, 2002  By /s/  KEVIN P. STARR      Kevin P. Starr   *Chief Operating Officer*   *and Chief Financial Officer*   *(principal financial and chief accounting officer)*   **
34

**EXHIBIT INDEX**

The following exhibit is filed as part of this Quarterly Report on Form 10-Q:
Exhibit No. Description  99.1 Statement Pursuant to 18 U.S.C. §1350 
35