<PAGE>

                                  EXHIBIT 10.49

                                      LEASE

                                     PARTIES

          101. THIS LEASE, made as of the 1st day of May, 1999 by and between
SOUTH BRUNSWICK RENTAL I, LTD., a New Jersey Limited Partnership (hereinafter
called "LANDLORD") and PHARMACOPEIA, INC. (hereinafter called "TENANT").

                                DEMISED PREMISES
          201. Landlord leases to Tenant and Tenant leases from Landlord all
that certain piece or parcel of land, together with the buildings and
improvements thereon, hereinafter collectively referred to as the "DEMISED
PREMISES" or "LEASED PREMISES" or "PREMISES", known as 2000 Princeton Park
Corporate Center and situate at 2000 Cornwall Road, South Brunswick Township,
Middlesex County, New Jersey (hereinafter called "LAND"), which Land is
described in Exhibit "A" attached hereto, and which space contains in the
aggregate approximately 86,000 square feet of rentable area on the first and
only floor of the building (hereinafter called the "BUILDING").

                                       USE

          301. Tenant shall use and occupy the Demised Premises solely for
office, manufacturing, and laboratory facilities and for any other lawful use,
all to be in conformance with Code and Ordinance, and for no other purpose.

                               TERM AND POSSESSION
          401. The term of this lease shall begin on the 1st day of May, 1999
(the "COMMENCEMENT DATE") and end at midnight on April 30, 2006 ("EXPIRATION
DATE").

          402. Tenant represents that the Premises, the street or streets,
sidewalks, parking areas, curbs and access ways adjoining them, any surface and
subsurface conditions thereof, and the present uses and non use thereof, have
been examined by Tenant, and Tenant accepts them in the condition or state in
which they now are, or any of them now is, without representation, covenant or
warranty, express or implied, in fact or in law, by Landlord and without
recourse to Landlord, the nature, condition or usability thereof or the use or
uses to which the Premises or any part thereof may be put.

          403. During the term hereof, Landlord may exercise all Landlord's
powers, authorities, remedies and benefits and shall perform all its
obligations, and Tenant may exercise all Tenant's powers, authorities, remedies,
and benefits and shall perform all obligations of Tenant.


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                                      RENT

          501. Tenant shall pay to Landlord as minimum rent the sum of ONE
MILLION SEVEN HUNDRED SIXTY-THREE THOUSAND DOLLARS ($1,763,000) per year in
equal monthly installments in advance of ONE HUNDRED FORTY-SIX THOUSAND NINE
HUNDRED SEVENTEEN DOLLARS ($146,917) each. The first monthly installment of
minimum rent shall be paid by Tenant to Landlord on the Commencement Date and
thereafter on the first day of each calendar month. In the event the lease term
shall commence at any time other than the first day of a calendar month, the
rental payment shall be pro rated for said month on a per them basis. In the
event rental payments have not been received within 15 days from the date the
monthly rental payments are due, in addition to any and all remedies available
to Landlord under this Lease, Tenant shall be charged and shall pay, in addition
to the outstanding rental payments, interest on the delinquent sum at the rate
of prime plus 2% which prime shall be the "prime" or "base" in effect for The
Bank of New York. This charge shall not preclude or be deemed a waiver of
Landlord's rights under Article XX of this Lease.

          502. In addition to the minimum rent referred to above, Tenant shall
pay, as Additional Rent, Real Estate Taxes as set forth below:

                 (a) For each year or part of a year occurring within the Term,
Tenant shall pay directly to applicable taxing authorities all real estate
taxes, assessments (subject to Section 502(h) below), water and sewer rents,
rates and charges (the "Real Estate Taxes") which shall be levied, imposed or
assessed upon the Real Property, which shall be paid on or before the date that
any fine, penalty, interest or cost may be added thereto for non-payment thereof
Tenant shall produce receipts to Landlord evidencing Tenant's timely payment of
Real Estate Taxes. Landlord shall, promptly after receipt thereof by Landlord,
forward all tax bills to Tenant.

                 (b) Tenant may take the benefit of the provision of any statute
or ordinance permitting any Real Estate Tax to be paid over a period of time but
if Tenant elects to do so, Tenant shall nevertheless pay all unpaid installments
prior to the expiration or sooner termination of this Lease, whether or not such
installments are then due.

                 (c) In the event the Real Estate Taxes have not been finally
determined by legal proceedings or otherwise at the time of payment of Real
Estate Taxes for any subsequent year, the actual amount of Real Estate Taxes
billed to Landlord shall be used to calculate such taxes. Upon a final
determination of the Real Estate Taxes by legal proceedings or otherwise,
Landlord shall deliver to Tenant a statement setting forth the amount of Real
Estate Taxes as finally determined and showing the computation of any adjustment
due by reason thereof Any payment due to Landlord or any credit due to Tenant by
reason of such adjustment shall be made as provided herein.

                 (d) If Landlord shall receive any tax refund in respect of any
tax year for Real Estate Taxes which are Tenant's obligation and which have been
paid by Tenant, Landlord shall deduct from such tax refund any expenses incurred
in obtaining such tax refund, and the remaining balance of such tax refund shall
be reimbursed by Landlord directly to the Tenant by check within 30 days. Any
reasonable expenses incurred by Landlord in contesting the validity or the
amount of the assessed valuation of the Real Property or of any Real Estate
Taxes for any year, to the extent not offset by a tax refund, shall be included
as an item of Real Estate Taxes for the tax year in which such contest shall be
finally determined for the purpose of computing the Additional Rent due Landlord
or any payment due to Tenant hereunder.

                 (e) If the tax year for Real Estate Taxes shall be changed,
then an appropriate adjustment shall be made in the computation of the
Additional Rent due to Landlord or any credit due to Tenant, in accordance with
sound accounting principles to effectuate the changeover to any new tax year
adopted by any taxing authority. Landlord shall give Tenant written notice of
any increase in Real Estate Taxes or assessments within 30 days after Landlord's
receipt of notice of such increase, but in any event prior to the date of the
running of any appeal period. "Real Estate Taxes" as set forth in this Section
502 shall mean those taxes attributable to the Real Property, provided that, if
because of any change in the method of taxation of real estate, any other tax or
assessment is imposed upon Landlord or the owner or the Land or the Building or
both or upon or with respect to the Land or the Building or both or the rents or
income therefrom in substitution for or in lieu of any tax or assessment which
would otherwise be a Real Estate Tax, such other tax or assessment shall be
deemed Real Estate Taxes for the purposes herein.


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<PAGE>

                 (f) If the last year of the Term ends on any day other than the
last day of a tax year, any payment due to Landlord or credit due to Tenant by
reason of any increase in Real Estate Taxes shall be prorated and Tenant
covenants to pay any amount due to Landlord within 30 days after being billed
therefor and Landlord covenants to credit any amount due to Tenant, as the case
may be. These covenants shall survive the expiration or termination of this
Lease.

                 (g) Tenant shall have the right within 30 days after notice
from Landlord to either request Landlord to appeal any increased assessment
resulting in any increase in Real Estate Taxes or to undertake the appeal
pursuant to the following provisions. Tenant shall have this right provided it
is not then in default under the lease and continues to conform and abide by any
and all provisions then in effect which must be fulfilled in order to allow for
such appeal including but not limited to the payment of any and all taxes which
said taxing authority requires to be paid within the time frame so specified,
and provided further that Tenant escrows with Landlord (or if required by
Landlord's Mortgagee, with such Mortgagee) an amount equal to the tax in
dispute. Tenant agrees should it so request Landlord in writing to file said
appeal on Tenant's behalf or if Tenant elects to undertake directly this appeal
on its own behalf to indemnify and hold Landlord harmless as well as any
assignee or nominee of Landlord, its mortgagee or any other person or entity
against any and all costs including but not limited to any further increases in
the assessment in the event that said taxing authority should elect, on any
appeal by Tenant or by Landlord at Tenant's request, if allowed by law, to cross
appeal on its own behalf said assessment and should be successful in further
increasing the assessment and/or other tax rate. Landlord agrees it will not
appeal any increased tax assessment without Tenant's consent, which will not be
unreasonably withheld, except no such consent of Tenant shall be required during
the final year of the Lease term.

                 (h) Anything herein to the contrary notwithstanding, if any
special assessments are levied against the Premises, Tenant shall be responsible
only for its proportional costs on a pro rata basis relating to the extent of
the Lease term over the total useful life of the improvements which are the
basis of such assessment. However, if such assessment was made by a reason of a
condition which has been created by, or at the instance of Tenant, or is
attributable to the use or manner of use to which Tenant puts the Premises, or
is attributable to a breach by Tenant of any of its covenants and agreements in
this Lease, Tenant shall be responsible for the entire assessment.

          503. It should be understood that this Lease is to be considered a
"net lease" and that, except as otherwise expressly provided in this Lease, the
Tenant shall pay all utilities and expenses incurred in the operation and
maintenance of the Building and incurred in the operation or maintenance of the
entire Premises. Notwithstanding the foregoing or Section 402 above, it is
understood and agreed that Landlord shall be responsible for repairs of any
structural defects or latent defects to the roof, walls and foundations of the
Building, unless such defects are caused by Tenant's use and occupancy of the
Premises. If any such structural defects or latent defects render the Premises
untenantable, and Landlord fails to make the repairs within 30 days after
written notice to Tenant, Tenant shall have the option to make such repairs or
replacements at its own cost and expense, and if Tenant obtains a final,
non-appealable judgment in a court of competent jurisdiction that Landlord was
obligated to make such repairs, Tenant shall be entitled to recover from
Landlord (and offset against rent) the amount expended by Tenant, plus interest
at the rate specified in Section 501, and reasonable attorneys' fees. Except as
set forth in that certain Letter Agreement of even date (the "Letter Agreement")
by and between Landlord and Tenant with respect to the payments due from Tenant
pursuant to Section 503(a) and (b), unless and until Tenant obtains such a
final, non-appealable judgment, it shall continue to pay all rent, without
offset, and Tenant's sole recourse, if such judgment is obtained against
Landlord shall be against Landlord or against future rents during the term of
the Lease.

          Tenant confirms that (a) the existing Building is acceptable for
Tenant's intended use, (b) the current condition of the Building, roof, walls
and foundation are acceptable, except that certain decorative slate panels glued
to the exterior facade of the Building have fallen off in the past and continues
to be a problem, and (c) Tenant has no knowledge of any structural defects.

          During each calendar year of the Lease term, or extended term, if
applicable, pro rata for any period less than a year, Tenant shall pay Landlord,
as Additional Rent, promptly upon being billed, a sum equal to the Operating
Expenses of the entire Premises for such calendar year which have not otherwise
been paid directly by Tenant. "OPERATING EXPENSES" as referred to in this lease
means the following expenses, costs and charges incurred for the operation,
maintenance and repair of the Land and Building:

                 (a) Cost of all insurance carried by Landlord, provided
premiums for insurance against loss or damage to the Building shall not exceed
SEVENTY-TWO THOUSAND DOLLARS ($72,000) per


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<PAGE>

year during the initial term of this Lease. However, Tenant shall be responsible
for any and all increase in premiums caused by its occupancy and use of the
Demised or Leased Premises, including without limitation increases caused by any
alterations or improvements installed by Tenant, Tenant's breach of this Lease,
or any other act or omission of Tenant;

                 (b) Landlord's management fees equal to $86,000 per annum,
which Tenant shall pay directly to the management company, if so directed by
Landlord;

                 (c) Cleaning, garbage removal, landscaping and grounds
maintenance, and any other maintenance charges reasonable required in the
operation of a building of this type that are requested to be performed by
Landlord, or which Landlord elects to perform after written notice to Tenant
that Tenant has failed to maintain the Premises as required by this Lease.

          All expenses to be taken into account pursuant to this Section shall
be "net" only and for such purpose shall be deemed reduced by the amounts of any
insurance or other reimbursement, recoupment, payment, discount, credit
reduction or allowance received by Landlord in connection with such expenses.

          On account of the Additional Rent payable pursuant to this Section
503, Tenant shall pay to Landlord on the first day of each month during the term
hereof in advance 1/12th of the amount Landlord estimates will be due to
Landlord hereunder for the current year. Not later than May 1 of each year of
this Lease, Landlord shall render a bill to Tenant, with appropriate
documentation, for such Additional Rent, together with a statement in reasonable
detail of the Operating Expenses, together with particular invoices, if
requested by Tenant and if available to Landlord, and within 60 days after the
rendering of such billing and statement, Tenant will pay any additional amount
shown to be due by said statement, or Landlord will credit any overpayment by
Tenant against payments thereafter to become due by Tenant pursuant to this
Section and the other provisions of this Lease. If the credit exceeds one
month's rent, and provided Tenant is not then in default, Landlord will
reimburse Tenant by check within 60 days.

          504. All sums payable under this Lease by Tenant, or which are at the
expense of Tenant, are deemed and considered to be rent, and if not paid,
Landlord shall have with respect thereto all the rights and remedies provided
for herein and by law for the nonpayment of rent.

          505. Rent and all sums payable hereunder by Tenant to Landlord shall
be paid without notice or demand, and without deduction (except as expressly
provided in the Lease or in the Letter Agreement), in then legal tender of the
United States of America for the payment off public and private debts by wire
transfer of immediately available funds to SOUTH BRUNSWICK RENTAL 1, LTD.,
Account No. 890-0318-481, Bank of New York, ABA No. 021-000-018, or to such
other person or place or in such other manner as Landlord shall from time to
time designate by written notice to Tenant. The management fee referred to in
Section 503(b) shall be paid to the Landlord's management company, as Landlord
shall direct.

                        MISCELLANEOUS COVENANTS OF TENANT

          601. Tenant shall

                 (a) pay the rent, Additional Rent, and all sums due under this
Lease without notice or demand on the days and times and at the places that the
same are payable and without abatement, deduction or set-off except as expressly
set forth in this Lease or the Letter Agreement; it being understood and agreed
that this is to be a net, net lease and except for any expenses or items
enumerated as expenses of the Landlord hereunder, such items shall be solely the
responsibility of the Tenant.

                 (b) keep the Demised Premises in good order and repair,
reasonable wear and tear and damage by any casualty not occurring through act of
Tenant or Tenant's agents, employees, or invitees excepted, and unless paid by
insurance on demand pay Landlord as additional rent, the cost of repair or
restoration of the Demised Premises. If the Building or Premises or any part
thereof is damaged in whole or in part by the act of Tenant or Tenant's agents,
employees or invitees, Landlord may at its option require Tenant to make the
appropriate repairs.


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<PAGE>

                 (c) peaceably deliver up and surrender possession of the
Demised Premises at the expiration or sooner termination of this Lease, in the
same condition in which Tenant has agreed to keep the same during the
continuance of this Lease, broom clean, and at such time without demand or delay
deliver to Landlord or its agent all keys for the Demised Premises, and upon
failure to deliver possession as aforesaid to pay to Landlord, at the beginning
of each month, an amount which shall be computed by applying, for the period
Tenant remains in possession thereafter, 150% of the sum of the highest minimum
annual rental rate and 100% of all additional rent under this Lease;

                 (d) except for the obligations of Landlord under Section 503 of
this Lease, promptly correct any violation of, and comply with, all laws,
ordinances, notices, permits, or statements of occupancy, requirements, orders
and regulations, now or hereafter in effect and of whatever nature of any and
all the Federal, State, County, Municipal and/or other authorities and of the
Board of Fire Underwriters and any insurance organizations of associations,
and/or companies, with respect to Tenant's conduct or use of the Demised
Premises, and on demand, pay to Landlord, as additional rent, any and all
increases in premiums on insurance (hazard and liability) now or hereafter
carried by Landlord on the Demised Premises, land or building, which increases
are caused in any way by the occupancy of Tenant or by breach of any of the
provisions of this lease;

                 (e) use every reasonable precaution against fire or other
casualty;

                 (f) give to Landlord prompt written notice of any accident,
fire, casualty or damage occurring on or to the Demised Premises, and of any
defects in the apparatus in the Demised Premises;

                 (g) repair or replace all electric lamps, lights, bulbs, glass
windows or fixture in the Demised Premises, as from time to time shall be
necessary;

                 (h) within ten days after written request therefore by
Landlord, deliver to Landlord in recordable form a certificate to such person as
Landlord may designate certifying (if such be the case) that this Lease be in
full force and effect, reflecting the commencement and expiration dates of the
Lease, and that there are no alleged defaults by Landlord or set-offs by Tenant
hereunder (or stating those claims by Tenant) and the date to which rent is
paid, both minimum and additional, and any other matter as Landlord may
reasonably request;

                 (i) omitted;

                 (j) 1. At Tenant's expense, Tenant shall comply with all laws
and ordinances, and all rules, orders and regulations of all governmental
authorities and of all insurance bodies, at any time duly issued or in force,
applicable to the Premises or any part thereof or to Tenant's use thereof,
except that Tenant shall not hereby be under any obligation to comply with any
law, ordinance, order or regulation requiring any structural alteration of or in
connection with the Premises, unless such alterations are required by reason of
a condition which has been created by, or at the instance of, Tenant, or is
attributable to the use or manner of use to which Tenant puts the Premises, or
is required by reason of a breach of any of Tenant's covenants and agreements
hereunder. Where any structural alteration of or in connection with the Premises
is required by any such law, ordinance, rule, order or regulation, and, by
reason of the express exception hereinabove contained, Tenant is not under any
obligation to make such alteration, then Landlord shall have the option of
making such alteration and paying the cost thereof.

                 2. Tenant agrees that it shall, at its sole cost and expense,
fulfill, observe and comply with all of the terms and provisions of the New
Jersey Industrial Site Recovery Act, N.J.S.A. 13:1K-6 ET SEQ., as the same may
be amended from time to time and all rules, regulation, ordinances, opinion,
orders and directives issued or promulgated pursuant to or in connection with
said Act by the Department of Environmental Protection ("DEP"), or any
subdivision or bureau thereof or any other governmental or quasi-governmental
agency, authority or body having jurisdiction. (Said Act and all of said rules,
regulations, ordinances, opinions, orders and directives are hereinafter in this
Article collectively referred to as "ISRA".) Without limiting the foregoing,
Tenant agrees that it shall provide DEP with a General Information Submission as
required under ISRA and a Site Evaluation Submission as required by ISRA and by
the DEP.

                 3. Without limiting the foregoing, upon the Landlord's written
request therefor, and in all events no later than 60 days prior to "closing,
terminating or transferring operations" (as said term is defined in


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ISRA) at all or any portion of the Premises, Tenant, at its sole cost and
expense, shall provide Landlord with a true copy of:

                         (i)  letter of non-applicability from DEP (or such
other agency or body as shall then have jurisdiction over ISRA matters), stating
that ISRA does not then apply to Tenant, Tenant's use and occupancy of the
Premises and said closing, terminating or transferring of operations; or

                        (ii)  a Negative Declaration (as said term is defined
in ISRA) duly approved by DEP or such other agency or body as shall then have
jurisdiction over ISRA matters; or

                       (iii)  a Cleanup plan (as said term is defined in
ISRA) duly approved by DEP or such other agency or body as shall then have
jurisdiction over ISRA matters; or

                        (iv)  any and all supporting documents and affidavits
involved in obtaining (i), (ii) or (iii).

          Nothing in this Paragraph 3 shall be construed as limiting Tenant's
obligation to otherwise comply with ISRA.

                 4. In the event Tenant complies with Paragraph 3 above, by
obtaining an approved Cleanup Plan, Tenant agrees that it shall, at its sole
cost and expense:

                         (i)  post any financial guarantee or other bond
required by DEP (or such other agency or body as shall have jurisdiction over
the Cleanup Plan) to secure implementation and completion of said Cleanup Plan;
and

                        (ii)  provide any stand-by trust required by DEP; and

                       (iii)  promptly implement and prosecute to completion
said Cleanup Plan, in accordance with the schedules contained in said Cleanup
Plan or as may be otherwise ordered or directed by DEP or such other agency or
body as shall then have jurisdiction over said Cleanup Plan. Tenant expressly
understands and acknowledges that Tenant's compliance with the provisions of
this paragraph may require Tenant to expend funds or do acts after the
expiration or termination of the term of this Lease. Tenant agrees that it shall
expend such funds and do such acts and Tenant shall not be excused therefrom
even though the term of this Lease shall have previously expired or been
terminated.

                 5. Within ten days after written request by the Landlord which
request by Landlord will not be exercised in an unreasonable manner or any
mortgagee or Landlord Tenant shall deliver to Landlord or Landlord's mortgagee
or ground lessor, as the case may be, a duly executed and acknowledged affidavit
of Tenant's chief executive officer certifying:

                         (i)  the proper four digit Standard Industrial
Classification number relating to Tenant's then current use or uses of the
Premises (said Standard Industrial

                         Classification number to be obtained by reference to
the then current Standard Industrial Classification Manual prepared and
published by the Executive Office of the President, Office of Management and
Budget or the successor to such publication); and

                        (ii)  (a)  if the facts so warrant, that Tenant's then
current use or uses of the Premises does not involve the generation,
manufacture, refining, transportation, treatment, storage, handling or disposal
of hazardous substances or wastes (as hazardous substances and hazardous wastes
are defined in ISRA) on site, above ground or below ground (all of the foregoing
being hereinafter collectively referred to as the "Presence of Hazardous
Substances"), or

                              (b)  that if Tenant's then present use or
uses of the Premises does involve the Presence of Hazardous Substances, said
affidavit shall describe in detail that portion of Tenant's operations which
involve the Presence of Hazardous Substances. Said description shall, inter
alia, identify each hazardous substance and describe the manner in which it is
generated, handled, manufactured, refined, transported,


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<PAGE>

treated, stored and/or disposed of Tenant shall supply Landlord or Landlord's
mortgagee with such additional information relating to said Presence of
Hazardous Substances as Landlord or Landlord's mortgagee may reasonably request,
which request will not require Tenant to reveal any trade secrets unless such
information is a requirement of local, state or federal law or reasonably
necessary for the preservation of the Building and/or Tenants contained therein,
their employees, servants, agents and invitees. If any trade secrets are
required to be disclosed Landlord agrees not to disclose same unless required by
law. Tenant shall furnish Landlord and Landlord's Mortgagee with copies of all
notices and reports to and from DEP regarding Tenant's use or uses or otherwise
pertaining to the Premises.

                 6. Without limiting the foregoing, Tenant agrees:

                         (i)  at its sole cost and expense, to promptly
discharge and remove any lien or other encumbrance arising out of ISRA and
Tenant's failure to comply with this Section against the Premises or any other
property owned or controlled in whole or in part by Landlord; and

                         (ii) to indemnify and hold Landlord harmless from
and against any and all liability, penalties, losses, expenses, damages, costs,
claims, causes of action, judgments and/or the like, of whatever nature,
including but not limited to reasonable fees and other costs of litigation or
preparation therefor, arising out of or in connection with and to the extent of
Tenant's failure or inability, for any reason whatsoever to observe or comply
with ISRA and/or the provisions of this Section.

                 7.       (i) Notwithstanding anything in this Lease to the
contrary, and without limiting the foregoing provisions of this Section,
Tenant agrees that it shall, at its sole cost and expense, observe, comply
and fulfill all of the terms and provisions of the Spill Compensation and
Control Act, N.J.S.A. 58:10-23.11 ET SEQ., as the same may be amended from
time to time and all rules, regulations, ordinances, opinions, orders and
directives issued or promulgated pursuant to or in connection with said Act
by DEP, any subdivision or bureau thereof or any other governmental or
quasi-governmental agency or body having jurisdiction. (Said Act and all of
said rules, regulations, ordinances, opinions, orders and directives are
hereinafter in this Article collectively referred to as "Spill Act".)

                         (ii) Without limiting the foregoing, Tenant agrees:

                                (a)     that it shall not do or omit to do nor
suffer the commission or omission of any act, the commission or omission of
which is prohibited by or may result in liability under the Spill Act, including
without limitation, the discharge of petroleum products or other hazardous
substances (as said terms are defined in the Spill Act); and

                                (b)     whenever the Spill Act requires the
"owner or operator" to do any act, Tenant shall do such act at its sole cost and
expense, it being the intention of the parties hereto that Landlord shall be
free of all expenses and obligations arising from or in connection with
compliance with the Spill Act and that Tenant shall fulfill all such obligations
and pay all such expenses.

                        (iii) Without limiting the foregoing, Tenant agrees:

                                (a)     at its own cost and expense, promptly
discharge and remove any lien or other encumbrance arising out of the Spill Act
and Tenant's failure (provided there is no failure on the part of any other
party previously occupying the Land and or Building) to comply with this Section
against the Demised or Leased Premises or any other property owned or
controlled, in whole or in part, by Landlord; and

                                (b)     to indemnify and hold Landlord harmless
from and against any and all liability, penalties, losses, expenses, damages,
costs, claims, causes of action, judgments and/or the like, or whatever nature,
including but not limited to reasonable attorneys' fees and other costs of
litigation or preparation therefor, arising out of or in connection with
Tenant's failure or inability, for any reason whatsoever, to observe or comply
with the Spill Act and/or the provisions of this Section, unless Tenant's
inability to so comply is caused by Landlord or by prior tenants of the
Premises.

                 8. Tenant covenants and agrees that Tenant shall in each and
every sublease that Tenant enters into for a portion of or all of the premises
include a provision in substantially the same form as this


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<PAGE>

Paragraph "j" but in any event specifically including a provision that the
subtenant shall comply with both ISRA and the Spill Act and shall indemnify and
hold Landlord harmless from and against any and all liabilities, penalties,
losses, expenses, damages, costs, claims, causes of action, judgments and/or the
like of whatever nature including, but not limited to, reasonable attorneys'
fees and other costs of litigation or preparation therefor arising out of or in
connection with and to the extent of Subtenant's failure or inability for any
reason whatsoever to observe or comply with either ISRA or the Spill Act and/or
the provisions of this section of the Sublease as is called for in this
paragraph. Tenant further covenants and agrees that whenever it is required in
this Paragraph "j" to give information or take action in regard to the use or
uses of the Premises, Tenant shall include therein the use or uses of any
subtenant.

                 9. Without limiting the foregoing provisions of this Section
601(j), Tenant agrees that it shall, at its cost and expense, promptly comply
with all federal, state and local laws, ordinances, rules, regulations and
requirements relating to air, ground and water pollution and protection and/or
preservation of the environment.

                 10. Tenant shall copy Landlord on all documents sent or
received by Tenant to DEP or an subdivision or bureau thereof or any other
governmental or quasi-governmental agency, authority or body having jurisdiction
over ISRA or the Spill Act or otherwise, relative to compliance with this
Section 601(j).

                 11. Tenant agrees that each and every provision of this Section
601(j) shall survive the expiration or earlier termination of the term of this
Lease, the parties hereto expressly agreeing and acknowledging that Landlord
would not enter into this Lease but for the provisions of this Section 601(j)
and the aforesaid survival thereof

                 12. Landlord and Tenant hereby agree that Tenant's obligations
pursuant to this Section 601(j) shall be with respect to Tenant's occupancy of
the Demised or Leased Premises (including periods of occupancy by Tenant prior
to the Commencement Date and under the Original Lease (as defined in Section
1604)) and not otherwise. During the term of this Lease and at its termination,
to the extent that the Tenant may be subject to ISRA and the Spill Act and/or
any other statute relating to the analysis of or remediation of environmental
conditions at the site, the levels of contamination (if any) which were found on
the site at the time this Lease was entered into shall be Landlord's
responsibility, except that as to any space in the Premises occupied by Tenant
prior to the Commencement Date (whether as subtenant of Enichem America, Inc.
("ENICHEM") or otherwise) Tenant shall be responsible for all conditions arising
from and after the date on which Tenant took occupancy of the space and which
were caused by Tenant's use and occupancy. Tenant agrees that any Negative
Declaration or Certificate of Non-Applicability obtained by Enichem, under ISRA
shall constitute confirmation that any future environmental problem was not
caused by and is not attributable to the actions of the prior tenant, provided
that Tenant shall not be bound by any false representations made by Enichem in
connection with any applications or submissions made by Enichem to DER.

          602. Without the express prior written consent and approval of the
Landlord, which consent will not be unreasonably withheld, Tenant, its agents,
employees or invitees or (when permitted) its assignees or sub-tenants shall
not, except as permitted under Article III hereof do any of the following:

                 (a) occupy the Demised Premises in any manner or for any
purpose except as permitted in this Lease;

                 (b) if Tenant is a corporation, merge with another entity or
liquidate or dissolve, or permit or allow control of said corporation to change
or be affected by the transfer of its stock except by reason of death of a
shareholder or shareholders or trading of its stock on a recognized public stock
exchange, unless the merger or other action results in the surviving entity
being at least as creditworthy as Tenant (after adjusting for any net loss carry
forward). Creditworthiness shall be tested by reference to net worth, but net
worth shall not necessarily be the exclusive test.

                 (c) make any alterations, improvements or additions to the
Demised Premises except as permitted and provided in Article XVI hereof;


                                       25
<PAGE>

                 (d) use or operate any machinery that, is harmful to the
Demised Premises and/or Building.

                 (e) place any weights in any portion of the Building beyond the
safe carrying capacity of the structure;

                 (f) do or suffer to be done, any act, matter or thing in
violation of the provisions of the insurance policies or whereby the said
insurance or any other insurance now in force or hereafter to be placed on the
Demised Premises, or on the Land or Building, shall become void or suspended, or
whereby the same shall be rated as a more hazardous risk than at the execution
hereof or at the time Tenant takes possession of the Demised Premises unless
Tenant agrees to pay such additional costs.

                 (g) except as is normally incident to the manufacture of
pharmaceutical products, or performance of pharmaceutical research and in
compliance with law, permit to continue any odor, noise, sound or vibration
which may, be detected outside the Building, and if occurring or should there
occur in isolated cases an "upset" in which event noxious fumes may be expelled
into the air, it shall be Tenant's responsibility to immediately correct and
eliminate any such emission or such incident and/or to correct any such noise,
sound or vibration.

                 (h) use or permit any of the toilet rooms, water closets,
sinks, or other apparatus or system to be used for any purpose other than for
which constructed, or permit any sweepings, rubbish, rags, ashes, chemicals, or
refuse or other unsuitable substances to be thrown or placed therein;

                 (i) place or allow to be placed any items on the outside of the
Building, on the windows, window sills or projections thereof, other than those
items that are approved in the plans and specifications;

                 (j) inscribe, paint or affix or permit to be inscribed,
painted, or affixed by any one any sign, advertisement or notice on any part of
the Building, inside or out, except within the Demised Premises. Notwithstanding
this provision, Landlord agrees, subject to compliance with applicable laws and
regulations and Landlord's approval as to the aesthetics of such, Tenant shall
have a right to place a sign on the land in front of the building, which sign
shall be maintained by Tenant at its expense.

                 (k) hang or shake any carpet, rug or other article, or throw or
drop the same or any dirt or other substance out of any window or door or down
the passageways or skylights in the Building or into or onto any common area,
adjoining Building or roof;

                 (l) except for laboratory animals, keep any animal in or
about the Demised Premises;

                 (m) except for normal and usual telephone, telegraph, and
telecommunication equipment, place any signaling, telephonic or other wires or
instruments in the Land, Building or Demised Premises except as directed by
Landlord, and without such direction no placement of any such apparatus shall be
permitted;

                 (n) enter upon the roof of the Building except to perform
routine maintenance of Building systems or Tenant's equipment on the roof, or in
an emergency affecting Tenant's operations, in which case notice may be oral.
Any maintenance to the roof shall be performed in the company of a
representative of Landlord or its managing agent;

                 (o) use electricity in the Demised Premises in excess of the
capacity of any of the electrical conductors and equipment in or otherwise
serving the Demised Premises, or add to or alter the electrical system servicing
the Demised Premises;

                 (p) use any part of the Demised Premises as sleeping rooms
or apartments;

                 (q) use or occupy the Demised Premises or permit or suffer the
same to be used or occupied in violation of the use regulation permit or
statement of occupancy issued for said Building or in violation of any statute,
ordinance or any requirement of any public authority, and the use permitted by
this Lease shall not be


                                       26
<PAGE>

deemed a representation or guarantee by Landlord that such use is lawful or
permitted under any permit or statement of occupancy or otherwise;

                 (r) attach any awnings, antennae or other projection to the
roof or outside walls of the Demised Premises or of the Building;

                 (s) execute or deliver any financing or security agreement or
statement that would be a lien upon the Demised Premises or the Land or
Building;

                 (t) erect, make or maintain on or attach or affix to, any part
of the Demised Premises or Building, including the windows and doors, any sign,
picture, television viewer or projection, or other representation or
advertisement or notice of any kind, which is visible from any location outside
of the Building or visible from the lobby of the Building, and no loud speaker
system or any other form of sound or audio transmission system or apparatus
shall be used in or at the Demised Premises or Building by Tenant, any
sub-tenant, or their respective agents or employees, for advertising or
promotional purposes;

                 (u) except as approved in plans and specifications or otherwise
permitted by Section 1601, lay or put upon the floors, any varnish, stain,
paint, linoleum, oilcloth, rubber or other air-tight covering, or fasten any
articles or drill any holes, nails or screws to the walls, doors or partitions,
or paint, paper or otherwise cover the same or mark or break the same.

                             RIGHTS RESERVED TO LANDLORD

          701. Provided not implemented in an unreasonable manner, or impairing
Tenant's use and enjoyment of the Demised Premises, Landlord shall have the
right, but shall be under no obligation, to do the following things (at any time
or times and from time to time) in or about the Demised Premises and the Land or
Building;

                 (a) discontinue any facility or service not expressly
covenanted for herein, as they constitute no part of the consideration for this
Lease;

                 (b) prevent access to the Building by any person during any
invasion, mob riot, public excitement or other commotion by closing the doors or
otherwise;

                 (c) [intentionally deleted];

                 (d) install, place upon or affix to the roof or exterior walls
of the Demised Premises and/or the Building, equipment, signs, displays,
antennae and any other object or structure provided it does not interfere with
Tenant's occupancy, use and enjoyment of the Premises;

                 (e) enter and go upon the Demised Premises and every part
thereof by itself or its duly authorized agents, by a master key, upon
reasonable notice during business hours and accompanied by a representative of
Tenant, and if an emergency, by telephonic notice if reasonably possible and if
not then without notice, without rendering Landlord or its agents liable or
subject to any action or prosecution therefor and without attesting the
obligations of Tenant under this Lease, for the purpose of doing any of the
following things in a manner intended not to unreasonably interfere with
Tenant's intended use of the Demised or Leased Premises:

                         (i)  inspect the Demised Premises and every part
thereof and make decorations, repairs, alterations and additions thereto and to
the Building and run wires, utility systems or appurtenance thereto and take
material as required into and upon the Demised Premises, all as Landlord shall
deem necessary for the safety, improvement, preservation or restoration of the
Building, or the Demised Premises, or for the safety or convenience of the
present or future occupants thereof;

                        (ii)  render any service to the Building or any
occupant, or exercise any of the Landlord's rights;


                                       27
<PAGE>

                         (iii)  take possession and alter, renovate and
redecorate at any time within one month prior to the expiration of this Lease if
Tenant has removed all or substantially all of Tenant's property.

          702. Except as set forth in this Lease, Tenant assumes responsibility
for services at the Premises.

                           COVENANT OF QUIET ENJOYMENT

          801. Landlord warrants that (a) it has the power and authority to
enter into this Lease, and (b) so long as Tenant performs every monetary and
material non-monetary obligation of Tenant under this Lease, Tenant shall
quietly enjoy the Demised Premises without hindrance by Landlord or anyone
claiming under the Landlord, subject however, to all of the provision of this
Lease.

                              WAIVER OF SUBROGATION
                 INDEMNIFICATION AND PUBLIC LIABILITY INSURANCE
                 -----------------------------------------------

          901. Tenant shall be responsible for and shall relieve, indemnify and
save Landlord harmless from and against: (a) all liability for loss of life,
personal injury and/or damage to property occurring in or about the Demised
Premises unless caused by the gross negligence of Landlord, its agents,
servants, employees, or invitees, and (b) any loss or damage from Tenant's
failure to perform its obligations under this Lease.

          902. Tenant shall maintain and pay for sufficient public liability
insurance to cover such indemnification in companies acceptable to Landlord,
naming Landlord, Landlord's Mortgagee and Tenant as insured, with minimum limit
of ONE MILLION DOLLARS ($1,000,000) for bodily injury or death to a single
person, and FIVE MILLION DOLLARS ($5,000,000) in respect to any one accident,
and FIFTY THOUSAND DOLLARS ($50,000) for property damage. Tenant shall deposit
such insurance policy, policies or certificates with Landlord with endorsement
thereto that (a) the policy will not be canceled without at least ten days prior
written notice to Landlord and Landlord's Mortgagee and (b) no act or omission
of Tenant will invalidate the interest of Landlord or Landlord's Mortgagee under
said insurance.

          903. Landlord and Tenant hereby release the other from any and all
liability or responsibility to the other or anyone claiming through or under
them by way of subrogation or otherwise for any loss or damage to property
covered by any insurance then in force, even if such loss or damage shall have
been caused by the fault or negligence of the other party, or anyone for whom
such party may be responsible, provided, however, that this release shall be
applicable and in force and effect only with respect to any loss or damage
occurring during such time as the policy or policies of insurance covering said
loss shall contain a clause or endorsement to the effect that this release shall
not adversely affect or impair said insurance or prejudice the right of the
insured to recover thereunder. Landlord and Tenant shall each have such clause
in its fire and extended coverage insurance policies if available without extra
charge, and if there be a charge, shall notify the other party and, in such
event, shall have the clause if the other party agrees to pay such extra charge.

          904. It shall be Landlord's responsibility to provide appropriate
property damage insurance in sufficient amounts to insure the replacement of any
items which are the responsibility of Landlord under the terms of this Lease,
the Building and any other fixtures or equipment purchased by Landlord. Landlord
shall provide to Tenant, upon request, an appropriate certificate reflecting
this coverage. The cost of such insurance shall be an Operating Expense.

                                   WAIVER OF CLAIMS

          1001. Unless caused by its willful or gross negligence, Landlord and
Landlord's agents, servants and employees shall not be liable for, and Tenant
hereby releases Landlord and Landlord's agents, servants and employees from all
claims for injury or damage to person or loss of or damage to property
(including any disappearance or theft of property and any loss or interruption
of business) sustained by Tenant, any person claiming through Tenant, or
sustained by any other person, resulting from any fire, accident, occurrence or
condition in or upon the Demised Premises, Land and Building or streets,
sidewalks, lawns, gardens, parking areas (if any) or other areas abutting or
adjacent to said Land or Building, including but not limited to such claims for
damages resulting from (i) any defect in or failure of plumbing, heating or air
conditioning equipment, elevators, electric wiring or installation thereof,
water pipes, stairs, railings or walks; (ii) any equipment or appurtenances
becoming out of repair;


                                       28
<PAGE>

(iii) the bursting, leaking or running of any tank, washstand, water closet,
waste pipe, drain or any other pipe or tank in, upon or about the Land, Building
or Demised Premises; (iv) the backing up of any sewer pipe or downspout; (v) the
escape of steam or hot water; (vi) water, snow or ice being upon or coming
through the roof or any other place upon or near such Building or premises or
otherwise; (vii) the falling of any fixture, plaster, or stucco; (viii) broken
glass; (ix) any act of omission of co-tenants or other occupants of the building
or adjoining or contiguous property or buildings; (x) the exercise of any rights
by Landlord under this Lease; (xi) any act or omission of Landlord, its agents,
servants and employees, unless said act or omission shall constitute a willful
breach of law or a willful breach of this Lease; (xii) any act or omission of
parties other than Landlord, its employees or agents. Tenant shall indemnify and
hold Landlord harmless with regard to any damage or liability occurring on the
Demised Premises or in connection with any act or negligence of Tenant.

                                  CONDEMNATION

          1101. Tenant hereby waives any injury, loss or damage, or claim
therefor, resulting from any exercise of a power of eminent domain affecting all
or any part of the Demised Premises or the air rights, Land or Building, except
that Tenant reserves against the condemning authority Tenant's right to, and
separate claim for, any damages for loss of good will, machinery and moving
expenses payable to tenants or lessees under the appropriate state code; in no
event, however, shall Tenant have or make any claim against Landlord, or the
condemning authority or any party having an interest in the air rights, Land or
Building, which would diminish or reduce the award for the air rights, Land or
Building.

          1102. In the event substantially all of the Demised Premises shall be
taken as a result of the exercise of a power of eminent domain, this Lease shall
terminate as of the date the right to possession vests in the condemning
authority and rent shall be apportioned as of that date. If only a part of the
Demised Premises shall be so taken, and this Lease is not terminated by Landlord
as hereinafter provided, the rent shall be abated in proportion to the area so
taken, as of the date the right to possession vests in the condemning authority.

          1103. In the event any part of the air rights, Land or Building, shall
be taken as a result of the exercise of a power of eminent domain (whether or
not the Demised Premises shall be affected), Landlord may, and Tenant may, if
such taking shall materially affect the operations of Tenant, by written notice
to the other party, given within 60 days after the date of taking, terminate
this Lease as of a date (to be set forth in said notice) not earlier than 30
days after the date of the notice; rent shall be apportioned as of the
termination date.

          1104. If the Demised Premises or the Building (a) are declared unsafe
by any duly constituted authority having the power to make such determination,
or (b) are the subject of a violation notice or notice requiring repair or
reconstruction, Landlord at its option, and provided such repair shall cost in
excess of available condemnation awards may terminate this Lease, and in such
event, Tenant shall immediately surrender said premises to Landlord and
thereupon this Lease shall terminate and the rent shall be apportioned as of the
date of such termination. In such event, Tenant waives all claims for injury,
and further waives all claims by reasons of any required surrender of possession
of the Demised Premises. In the event such repair shall be in excess of
available condemnation awards, Tenant shall have the option to make such repairs
at its own cost and expense, providing Tenant shall comply with any and all
provisions set forth in Article XVI of this Lease. In the event such repair
shall not cost in excess of available condemnation awards, Landlord shall be
required to make such repairs.

                              DAMAGE OR DESTRUCTION

          1201. If the Demised Premises are damaged by the elements or fire or
other casualty, not due to Tenant's negligence, Landlord (subject to Section
1202 below) shall repair the damage, but the rent shall not be abated unless the
Demised Premises are thereby rendered untenantable in whole or in part; if
rendered untenantable only in part, the minimum rent and additional rent shall
be abated in proportion to the part rendered untenantable; if rendered wholly
untenantable, the entire minimum rent and additional rent shall be abated
provided, however, that in such event Landlord shall have the right to terminate
this Lease as of the date of the occurrence by written notice to Tenant within
60 days thereafter. In the event such repair shall be in excess of available
insurance proceeds, Tenant shall have the option to make such repairs at its own
cost and expense, providing Tenant shall comply with any and all provisions set
forth in Article XVI of this Lease. In the event such repair shall not cost in
excess of available insurance proceeds, Landlord shall be required to make such
repairs. However, if such casualty has occurred during


                                       29
<PAGE>

the last six months of the Lease Term, or any extended Term, Landlord need not
repair or restore unless Tenant has agreed or then agrees to exercise either the
first or second option under this Lease.

          1202. If the Building shall, in Landlord's opinion, be substantially
damaged to the extent of more than available insurance proceeds by the elements
or fire or other casualty, or in its reasonable opinion cannot be repaired
within 60 days, Landlord shall have the right, provided Tenant has not exercised
its rights under Section 1201 above, by written notice to Tenant within 60 days
after said occurrence, to terminate this Lease (unless terminated pursuant to
Section 1201) or if not repaired by Landlord within said 60 day period Tenant
may, after 30 days following said 60 day period, upon written notice, cancel its
obligations under this Lease and in either such event this Lease shall end as of
the date of such notice and the minimum rent and additional rent shall be
adjusted as of the date of said occurrence.

                                   SUBORDINATION TO
                   LANDLORD'S DOCUMENTS OF POSSESSION AND MORTGAGE

          1301. Tenant acknowledges that this Lease and Tenant's rights
hereunder are subject and subordinate to (a) all agreements by and through which
Landlord has possession of the Building and the Demised Premises (herein
referred to as "Landlord's documents of possession") and to all mortgages now or
hereafter placed upon the Landlord's estate in the Building and the Demised
Premises and, if there be merger of Landlord's estate and the fee title, upon
the fee title.

          1302. If any Mortgagee or other person shall acquire title to the
Landlord's estate or the Demised Premises or building for foreclosure, deed in
lieu thereof, or otherwise, or, at any time during the term of this Lease, the
Landlord of the Demised Premises shall be the holder of a leasehold estate
covering Premises which include the Demised Premises, and if such leasehold
estate shall terminate or be terminated for any reason, Tenant agrees, at the
election and upon written notice of any owner of the premises which include the
Demised Premises, or, of any Mortgagee in possession thereof, or of any holder
of a leasehold thereafter affecting premises which include the Demised Premises,
to attorn, from time to time, to any such owner Mortgagee or holder, upon the
terms and conditions set forth herein for the remainder of the term demised in
this Lease, subject to Section 1303 below.

          The foregoing provisions shall enure to the benefit of any such owner,
Mortgagee or holder and shall be self-operative upon any such demand, without
requiring any further instrument to give effect to such provisions. Tenant,
however, upon demand of any such owner, mortgagee or holder, agrees to execute,
from time to time, an instrument in confirmation of the foregoing provisions,
satisfactory to any such owner, mortgagee or holder, in which Tenant shall
acknowledge such attainment and shall set forth the terms and conditions of its
tenancy which shall be the same as those set forth herein and shall apply for
the remainder of the term originally demised in this Lease. Nothing contained in
this article shall be construed to impair any right otherwise exercisable to any
such owner, mortgagee or holder. As a condition of Tenant's obligations under
this Section 1302, any present or future mortgagee shall furnish a Subordination
and Non-Disturbance Agreement for the benefit of Tenant as provided in Section
1303 below.

          1303. Notwithstanding Sections 1301 and 1302, this Lease shall not be
subordinate to any Mortgage hereafter placed unless the holder of the Mortgage
in question shall provide a non-disturbance agreement to Tenant which shall
provide in substance that so long as Tenant shall not be in default hereunder,
the mortgagee shall not name Tenant as a party defendant in any action to
foreclose the Mortgage nor will this Lease be terminated or the possession of
Tenant of the Premises be disturbed by any such action. Tenant shall, upon
request of the holder of any Mortgage, enter into such subordination and
non-disturbance agreement and if the holder is a bank, insurance company or
other institutional tender, such agreement may contain such other provisions as
are contained in such holder's usual or standard form of subordination and
non-disturbance agreement.

                           ASSIGNMENTS AND SUBLETTING

          1401. Except to an affiliate, parent, or subsidiary of Tenant, Tenant
shall not, without the prior consent of the Landlord (and to the extent required
by Landlord's Mortgagees, the consent of Landlord's Mortgagees), assign,
mortgage or pledge this Lease or underlet or sublease the Demised Premises, or
any part thereof, or permit any other person, firm or corporation to occupy the
Demised Premises, or any part thereof, which consent of Landlord (and, if
required, its Mortgagees) shall not be unreasonably withheld or delayed. A
proposed assignment of this lease respecting only a portion of the Demised
Premises shall be deemed a "subletting" within the


                                       30
<PAGE>

foregoing sentence. Anything herein to the contrary notwithstanding, the
existing subletting by Tenant of the Greenhouse is a permitted subletting, and
Tenant shall have the right during the term of this Lease (but not any renewal
or extension periods) to sublet up to 50% of the space in the Premises in the
aggregate (including the Greenhouse) without Landlord's consent so long as there
is no event of default then existing pursuant to Section 2001. Tenant shall
furnish Landlord with a copy of any agreement pertaining to any assignment or
subletting. Notwithstanding anything contained herein, any assignment or
subletting (whether or not consented to by Landlord) shall not release Tenant of
any of its obligations under this Lease.

                              RULES AND REGULATIONS

          1501.  Intentionally omitted.

                                 ALTERATIONS AND
                      SERVICES BY TENANT AND TRADE FIXTURES

          1601. Tenant shall not after commencement and occupancy under the
Lease do any work in or about the Demised Premises or make any alterations or
additions thereto without the prior written consent of Landlord, which consent
Landlord will not unreasonably withhold, except Tenant may make such alterations
or additions without the prior written consent of Landlord to the extent of
FIFTY THOUSAND DOLLARS ($50,000) per project or related series of projects
provided such additions or alterations do not affect the roof or any structural
portion of the Building or affect any system (s) of the Building. All such work
to which Landlord consents shall be performed and installed at Tenant's sole
cost and expense in accordance with plans and specifications to be supplied by
Tenant, which plans, and the contractors, subcontractors and all suppliers of
labor or material shall in all instances first be subject to Landlord's
approval, which approval shall not be unreasonably withheld. During the work,
Tenant shall maintain such insurance as Landlord may reasonably require for the
benefit of Landlord or such other parties as Landlord shall designate. Landlord
may require that Tenant furnish a guarantee by each of Tenant's prime
contractors and materialmen for the benefit of Landlord, Tenant and such other
parties as Landlord shall designate that all work, materials and equipment will
be in accordance with the plans and specifications and that they will promptly,
upon notice, correct and repair at their own cost and expense any deficiency,
defect, fault or imperfection of materials, equipment or workmanship which
appears within one year after completion of their work or installation.

          1602. No work or installation by Tenant at the Demised Premises, Land
or Building, shall be done except after providing to Landlord appropriate
assurances including, but not limited to, guarantees and indemnifications in
connection with the possible filing of any mechanics liens and/or notice of
intention to file a mechanics lien, filing of a waiver of the right to file any
lien therefor (commonly known as a "mechanics" lien) in the local Office, as
provided by law, so as to constitute an effective waiver by anyone having a
right to file such a lien, if such a notice of intention is filed. If any such
lien is filed, Tenant shall cause it to be discharged or satisfied within 30
days of filing.

          1603. No work, services or installation by Tenant in or about the
Demised Premises, Land or Building, shall be performed or installed except by
workmen and mechanics working in harmony and not reasonably interfering with
labor employed by Landlord, Landlord's mechanics or their contractors or by any
other Tenant or their contractors. Any violation hereof shall automatically
constitute a permitted cancellation by Landlord of any prior Landlord's consent
to or permission for such work or installation.

          1604. Any alterations, improvements or additions made by Tenant after
occupancy under the Lease (or under the Lease dated June 21, 1996 by and between
Landlord and Tenant relating to the Premises (the "Original Lease")), except
pursuant to a written consent by Landlord which provides that Tenant may remove
the same, shall remain upon the Premises at the expiration or earlier
termination of this Lease and shall become the property of Landlord. Any
alterations, improvements or additions made by Landlord for Tenant shall remain
the property of Landlord at expiration or earlier termination of this Lease.
Should Tenant fail to remove any alterations, improvements or additions required
to be removed by it, Landlord may do it, and Tenant shall pay the cost and
expense thereof to Landlord as additional rent upon demand.

          1605. Except for any fixtures or equipment purchased or installed by
Landlord, which shall belong to the Landlord, all fixtures and equipment owned
by Tenant in the Demised Premises ("TENANT'S FIXTURES"), except lighting
fixtures and air conditioning equipment, shall remain the property of Tenant and
(except as set forth in Section 1604) shall be removed on or before the
termination date of this Lease, but at Landlord's option, any


                                      31
<PAGE>

fixtures not removed on or before the lease termination date shall either become
Landlord's property, or Landlord may remove and dispose of them, and in such
event Tenant shall pay the cost and expense thereof to Landlord as additional
rent upon demand. Upon removal of Tenant's Fixtures, Tenant shall promptly
restore the Demised or Leased Premises to the original order and condition
existing immediately prior to such removal of Tenant's Fixtures and shall repair
any and all damage caused by said removal. Any and all other fixtures installed
by Landlord prior to the commencement of this Lease shall remain the property of
the Landlord.

          1606. In the event Tenant shall enter into any arrangement to finance
all or any portion of the Tenant's Fixtures (as defined in Section 1605), either
before or after the installation or placement thereof upon the Leased Premises
and regardless of whether such financing shall be in the form of a security
agreement, equipment lease, equipment sale/leaseback or otherwise, Landlord
agrees within 30 days after request therefor to execute and deliver a customary
waiver of lien to evidence Landlord's agreement that Landlord waives any lien
rights or claims in the Tenant's Fixtures, provided that Landlord and its
Mortgagees first receive (i) an itemized list of the Tenant's Fixtures which are
subject to the Lease or financing arrangement, and (ii) an agreement in form and
substance reasonably satisfactory to Landlord and its Mortgagees that the owner
and/or lessor and/or financing party (x) will not remove any Tenant's Fixtures
except upon prior notice to Landlord and its Mortgagees, and at reasonable
business hours and (y) will indemnify, defend and hold Landlord and its
Mortgagees harmless from and against any loss, cost, liability, damage or
expense (including reasonable attorneys fees) caused by or arising from the
removal of any Tenant's Fixtures.

                        PERFORMANCE OF TENANT'S COVENANTS

          1701. Except for the payments of rent and Additional Rent, which shall
be payable when due, Tenant shall perform all agreements on its part to be
performed within such period provided in Section 2001 and if Tenant does not
perform to Landlord's reasonable satisfaction within such time periods, Landlord
may, at its option, upon written notice to Tenant (except for emergency
situations, in which case notice may be oral) perform for Tenant and in so doing
Landlord shall have the right to cause its agents, employees and contractors to
enter upon the Demised Premises without liability to Tenant for any loss or
damage resulting therefrom; and Tenant shall pay the cost and expense of such
performance, together with interest as set forth in Section 501 herein, to
Landlord as additional rent upon demand.

                                    AIR AND LIGHT

          1801. This Lease does not grant any right to light and air.

                                       NOTICES

          1901. Any notice or demand given by Landlord to Tenant shall be in
writing and shall be sent by registered or certified mail, postage prepaid

                 ADDRESSED TO TENANT AS FOLLOWS:
                 --------------------------------

                 PHARMACOPEIA, INC.
                 3000 Eastpark Boulevard, 2nd Floor
                 Cranbury, NJ  08512
                 Attention:  Lewis J. Shuster

or to such other address as Tenant may from time to time designate by written
notice to Landlord.

          Any notice or demand to be given by Tenant to Landlord shall not be
deemed to have been duly given or served unless in writing and forwarded by
registered or certified mail, postage prepaid,

                 ADDRESSED TO LANDLORD AS FOLLOWS:
                 ---------------------------------

                 SOUTH BRUNSWICK RENTAL I, LTD.
                 c/o PHILIP S. SELTZER, General Partner
                 455 Pennsylvania Avenue, Suite 125


                                       32
<PAGE>

                 P. O. Box 325
                 Ft. Washington, PA  19034

                 WITH A COPY TO:
                 ---------------

                 A. J. Land, Comptroller
                 c/o PHILIP S. SELTZER, General Partner
                 P. O. Box 325
                 Ft. Washington, PA  19034

or to such other address or addresses as Landlord may from time to time
designate by written notice to Tenant.

The customary mail receipt shall be evidence of service of notice.

                                  EVENTS OF DEFAULT

          2001. Each of the following shall constitute an event of default
hereunder:

                 (a) The filing by or against Tenant of a petition for
adjudication as a bankrupt or insolvent, or for reorganization or appointment of
a receiver or trustee of Tenant's property; an assignment by Tenant for the
benefit of creditors; or the taking possession of Tenant's property; an
assignment by Tenant for the benefit of creditors; or the taking possession of
Tenant's property by a governmental officer or agency pursuant to statutory
authority for the dissolution or liquidation of Tenant;

                 (b) Tenant failing to pay when due any sum herein required to
be paid by Tenant; however, Tenant shall be provided in any 12 month period of
this Lease term with no more than two notices of non-payment of rent and
requiring payment within ten days of receipt thereof In the event that Tenant
shall receive two notices during an 12 month period, Tenant thereafter shall be
in default under this Lease in the event that it has failed to pay when due any
sum herein required to be paid by Tenant and no further notice will be required
to be provided to Tenant.

                 (c) Tenant failing to perform any other covenant or condition
of this Lease within 30 days after written notice and demand, or, if the
performance requires more than 30 days to complete, failing to begin performance
within 30 days and completing diligently thereafter, but in no event later than
30 days thereafter;

                    RIGHTS OF LANDLORD UPON DEFAULT BY TENANT

          2101.  In the event of the occurrence of an event of default
hereunder, at the sole option of Landlord, and to the extent permitted by law;

                 (a) The whole balance of rent for the entire term less any net
proceeds to be due pursuant to a sublet, which subletting shall not be the
responsibility or obligation of Landlord, and other charges, payments, taxes,
costs, fees and expenses herein agreed to be paid by Tenant or any part thereof,
and also all costs and officers' commissions, including watchman's wages, and a
collection fee of 5% shall be taken to be due and payable and in arrears as if
by the terms and provisions of this Lease said balance or rent and other
charges, payments, taxes, costs, fees and expenses were on that date payable in
advance; and

                 (b) This Lease and the term hereby created shall, at the option
of Landlord, determine and become absolutely void without any right on the part
of Tenant to save the forfeiture by payment of any sum due or by other
performance of any condition, term or covenant broken; and

                         (i)    Landlord may, without notice or demand, enter
the Demised Premises, breaking open locked doors, if necessary, to effect
entrance, without liability to action for prosecution or damages for such entry
or for the manner thereof, for the purpose of recovering possession and for
other purposes, and Tenant hereby releases and discharges Landlord and its
agents from all claims, actions, suits, damages and penalties, for or by reason
or on account of any entry; and


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                        (ii)    proceed to collect or otherwise sue for the
total amount so due or any part thereof, and

                       (iii)    provided always that if Tenant without any
previous demand (except as otherwise expressly provided herein) shall fail or
omit to pay the rents or sums hereby reserved on the days and at the times when
the same are made payable, or shall in any other respect fail to fulfill any of
the obligations imposed upon Tenant hereunder, then this Lease and the term
hereby created shall, at Landlord's option, to be signified by a written notice
of its intention so to determine this Lease on any day therein fixed, delivered
to Tenant or left at the Demised Premises at least five days previous to the day
so fixed, determined and become absolutely void without any right on the part of
Tenant after the day so fixed to save the forfeiture by payment of rent due or
by other performance of the covenants or conditions thus violated.

                        (iv)    Landlord may lease said premises or any part or
parts thereof to such person or persons as may in Landlord's discretion seem
best, and Tenant shall be liable for any loss of rent for the balance of the
term.

                 (c) If proceedings shall be commenced by Landlord to recover
possession under the appropriate state law, either at the end of the term or
sooner termination of this lease, or for non-payment of rent or any other
reason, Tenant specifically waives the right to notice greater than five days
that may be required by any state Act and agrees that five days notice shall be
sufficient in any case.

                 (d) The right to enforce all of the provisions of this Lease
hereinabove provided for may, at the option of any assignee of this Lease, be
exercised by any assignee of Landlord's right, title and interest in this Lease
in his, her or their own name, notwithstanding the fact that any or all
assignments of the said right, title and interest may not be executed and/or
witnesses in accordance with the appropriate state law that has been or may
hereafter be passed, and Tenant hereby expressly waives the requirements of any
and all laws regulating the manner and/or form in which such assignments shall
be executed and witnessed.

                 (e) Tenant shall pay the reasonable expenses of Landlord,
including reasonable attorney's fees, incurred in enforcing any of the
obligations of Tenant under this Lease, or in any litigation in which Landlord
shall, without fault of Landlord, become involved through or on account of this
Lease.

                 (f) Tenant may not cure a default and save forfeiture or
prevent other remedy of Landlord following expiration of notice period herein
provided and a default must be cured in its entirety to be considered as cured
within the said notice period.

          2102. No determination of this Lease not taking or recovering
possession of the premises, shall deprive Landlord of any remedies or actions
against Tenant for rent or for damages for the breach of any covenant herein
contained nor shall the bringing of any such action for rent or breach of
covenant, nor the resort to any other remedy herein provided for the recovery of
rent or damages for such breach be construed as a waiver of the right to insist
upon for forfeiture and to obtain possession in the manner herein provided.

          2103. Tenant expressly waives the benefit of any and all laws now made
or which may hereafter be made, exempting or releasing goods on said premises or
elsewhere any property in any way belonging to Tenant, from levy and sale upon
distress for rent or other charges herein reserved or payable as rent,
or upon an execution on any judgment obtained in an action brought for
non-payment of rent, or in any and all suits, actions or proceedings, amicable
or otherwise, for the collection of rent or other charges herein reserved or
payable as rent due and in arrears, for any expense incurred in removing rubbish
or refuse matter from said premises, and for any damage for the non-fulfillment
of any of the covenants herein contained.

          2104. All remedies hereinbefore given to Landlord and all rights and
remedies given to it at law and in equity shall be cumulative and concurrent.

                                   TERMINATION

          2201. Unless extended pursuant to an option, this Lease shall
terminate automatically at the end of the term or extended term of this Lease
without any notice required by either party.


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                                CUSTOM AND USAGE

          2301. Landlord shall have the right at all times to enforce the
covenants and conditions of this Lease in strict accordance with the terms
hereof despite any conduct or custom on the part of the Landlord in refraining
from so doing at any time or times, and despite any contrary law, usage or
custom or any failure by Landlord to enforce its rights at any time or times.

                        SCOPE AND INTERPRETATION OF AGREEMENT

          2401. This Lease is the only agreement between the parties hereto
pertaining to the Demised Premises, and all negotiations and oral agreements
acceptable to the parties are included herein. The laws of the state in which
the Demised Premises is located shall govern the validity, interpretation,
performance and enforcement of this Lease.

                                    CAPTIONS

          2501. Any headings preceding the text of the several Articles and
subparagraphs hereof are inserted solely for convenience of reference and shall
not constitute a part of this Lease nor shall they affect its meaning,
construction or effect.

                                     SEVERABILITY

          2601. If any provision of this Lease is held to be invalid, the
remaining provisions shall not be affected thereby but shall continue in full
force and effect.

                           PARTIES, SUCCESSORS AND ASSIGNS

          2701. The term "Tenant" shall refer to each and every person or party
mentioned as a Tenant herein, be the same one or more. If there shall be more
than one Tenant, they shall be bound jointly and severally by all of the terms,
covenants and agreements of this Lease and any notice required or permitted by
the terms of this Lease may be given by or to any one thereof and shall have the
same force and effect as if given by or to all.

          2702. The term "LANDLORD" as used in this Lease shall refer only to
the owner for the time being of Landlord's estate in the Demised Premises or the
Building of which it is a part. Landlord shall be and is hereby relieved of all
covenants and obligations of Landlord hereunder after the date of transfer of
Landlord's estate in the Demised Premises or the Building of which it is a part,
and it shall be construed without further agreement between the parties that the
transferee has assumed and agreed to carry out any and all covenants and
obligations of Landlord hereunder during such time as said transferee shall own
or hold Landlord's estate or interest in the Demised Premises or the Building of
which it is a part. The provisions of this Article XXVI shall apply to each
successive transfer of Landlord's interest or estate. The liability of the
Landlord under this Lease shall be and is hereby limited to Landlord's interest
in the Premises, and no other asset of Landlord shall be affected by reason of
any liability which Landlord may have to Tenant or to any other person by reason
of this Lease, the execution thereof, or the acquisition of Landlord's interest.

          2703. Subject to the provisions of 2702 hereof, all right, obligations
and liabilities hereupon given to or imposed upon the respective parties hereto
shall extend to and bind the several and respective heirs, executors,
administrators, successors, sub-tenants and assigns of said parties.

                                SECURITY DEPOSIT

          2801.  Upon execution of this Lease, Landlord shall refund to Tenant
its security deposit of ONE HUNDRED FORTY-THREE THOUSAND THREE HUNDRED
THIRTY-THREE DOLLARS ($143,333) relating to the Original Lease. There is no
security deposit required under this Lease.


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          2901.  Intentionally omitted.

                                OPTIONS TO EXTEND

          3001. Provided Tenant is not in default with regard to any of the
monetary or material non-monetary terms of this Lease, the Landlord agrees that
Tenant shall have and is hereby granted two successive options to extend the
term of this Lease for a period of three years for the first option and five
years for the second option. Such extended term(s) to begin respectively upon
the expiration of the term of this Lease or of this Lease as extended, and all
the terms, covenants and provisions of this Lease shall apply to each such
extended term with the exception, however, that the Tenant shall not have any
further option to again extend the term of this Lease following the exercise, if
any, of the second option to extend. If the Tenant shall elect to exercise the
aforesaid option(s), it shall do so by written notice to Landlord no later than
twelve months prior to the expiration of the term of this Lease or of this Lease
as extended. The annual rent during the two option periods shall equal 95% of
the fair market value rental of the Premises as determined pursuant to Section
3002.

          3002. The annual rent for the option period will be determined as
follows:

                 (a) Landlord and Tenant will have fifteen (15) days after
Landlord receives the option notice within which to agree on the then-fair
market rental value of the Premises, as defined in paragraph (a)(3), and rental
increases to the monthly rent for the option period. If they agree on the
initial monthly rent and rental increases for the option period within fifteen
(15) days, they will amend this Lease by stating the initial monthly rent and
rental increases for the option period.

                 (b) If they are unable to agree on the initial monthly rent and
rental increases for the option period within fifteen (15) days, then, the
initial monthly rent for the option period will be the then-fair market rental
value of the Premises as determined in accordance with paragraph (d) and the
periodic rental increases will be consistent with current market standards for
rent increases at that time, in amounts and at frequencies determined by the
appraisers pursuant to paragraph (d).

                 (c) The "then-fair market rental value of the Premises" means
what a landlord under no compulsion to lease the premises and a tenant under no
compulsion to lease the premises would determine as rents for the option period,
as of the commencement of the option period, taking into consideration the uses
permitted under this Lease, the quality, size, design and location of the
Premises, the rent for comparable buildings located in the market in which the
Premises are located of the Premises and that Landlord is providing no work
letter and no services to Tenant.

                 (d) Within seven (7) days after the expiration of the fifteen
(15) day period set forth in paragraph (b), Landlord and Tenant will each
appoint a real estate appraiser with at least five (5) years' full-time
commercial appraisal experience in the area in which the Premises are located to
appraise the then-fair market rental value of the Premises. If either Landlord
or Tenant does not appoint an appraiser within ten (10) days after the other has
given notice of the name of its appraiser, the single appraiser appointed will
be the sole appraiser and will set the then-fair market rental value of the
Premises. If two (2) appraisers are appointed pursuant to this paragraph, they
will meet promptly and attempt to set the then-fair market rental value of the
premises. If they are unable to agree within thirty (30) days after the second
appraiser has been appointed, they will attempt to elect a third appraiser
meeting the qualifications stated in this paragraph within ten (10) days after
the last day the two (2) appraisers are given to set the then-fair market rental
value of the Premises. If they are unable to agree on the third appraiser,
either Landlord or Tenant, by giving ten (10) days' prior notice to the other,
can apply to the then-presiding judge of the Superior Court of Middlesex County
for the selection of a third appraiser who meets the qualifications stated in
this paragraph. Landlord and Tenant will bear one-half (1/2) of the cost of
appointing the third appraiser and of paying the third appraiser's fee. The
third appraiser, however selected, must be a person who has not previously acted
in any capacity for either Landlord or Tenant.

                 Within thirty (30) days after the selection of the third
appraiser, a majority of the appraisers will set the then-fair market rental
value of the Premises. If a majority of the appraisers are unable to set


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the then-fair market rental value of the Premises within thirty (30) days after
selection of the third appraiser, the three (3) appraisals will be averaged and
the average will be the then-fair market rental value of the Premises.


          IN WITNESS WHEREOF, the parties have caused these presents to be duly
executed as a sealed instrument as of the day and year first above written.

                              LANDLORD:

Witness:
                              SOUTH BRUNSWICK RENTAL I, LTD.

                              By: /s/ Philip S. Seltzer
---------------------------       ---------------------------------------------
                              Its: General Partner

                              TENANT:

Attest:                       PHARMACOPEIA, INC.

                              By: /s/ Lewis J. Shuster
--------------------------        ---------------------------------------------
                              Its: President and COO, Pharmacopeia Laboratories



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