----

----

----

|                                      |                                           |
|-------------------------------------------|------------------------------------------------|
| COS Reference #: P-TRP-54564-R1-COS-01-R0 | Prana Biotechnology Limited                    |
| Issue Date: July 10, 2013                 | PBT2 Capsules - Phase I BE Batch Manufacturing |
| Confidential                              | Page 2 of 5                                    |

----

|            |                                   |                |                       |            |   |        |   |   |   |    |   |   |
|-----------------|----------------------------------------|---------------------|----------------------------|-----------------|--------|-------------|--------|--------|--------|---------|--------|--------|
| Part B: Pricing |                                   |                |
|            |                                   |                |
| BUDGET SUMMARY  |
|            |                                   |                |                       |            |   |        |   |
|            | THE FOLLOWING COSTS ARE ALL QUOTED IN: | USD                 |                       |            |   |        |   |
|            |                                   |                |                       |            |   |        |   |
|            | CTM BATCHES (ED)                       |                |                       |            |   |        | USD    |
|            |                                   | ACTIVITY            |                       | MILESTONE PRICE |   | PRICE       |
|            |                                   |                |                       |            |   |        |   |   |   |    |   |
|            | First Batch                       | Manufacturing       |                       |            | $      | 37,632      |   |   |   |    |   |
|            |                                   | Packaging           |                       |            | $      |  9,403 |   |   |   |    |   |
|            |                                   | Analytical Support  |                       |            | $      | 19,142      |   |   |   |    |   |
|            |                                   |                | Total Per Batch            |            | $      | 66,177      |   |   |   |    |   |
|            |                                   |                | 1 Batch TOTAL              |            |   |        |   |   | $      | 66,177  |   |
|            | Back to Back Batch                | Manufacturing       |                       |            | $      | 33,638      |   |   |   |    |   |
|            |                                   | Packaging           |                       |            | $      | 8,328       |   |   |   |    |   |
|            |                                   | Analytical Support  |                       |            | $      | 10,400      |   |   |   |    |   |
|            |                                   |                | Total Per Batch            |            | $      | 52,366      |   |   |   |    |   |
|            |                                   |                | 1 Back to Back Batch TOTAL |            |   |        |   |   | $      | 52,366  |   |
|            |                                   |                |                       |            |   |        |   |   |   |    |   |
|            |                                   | Total               |                       |            |   |        |   |   | $      | 118,543 |   |
|            |                                   |                | Material and Supply Fee:   |            | $      | 5,927       |   |
| 24.0            | STABILITY - CTM                        |                |                       |            |   |        | USD    |
|            |                                   | ACTIVITY            |                       |            |   |        |   |   |   | PRICE   |
|            |                                   |                |                       |            |   |        |   |   |   |    |   |   |
|            |                                   | Number of Lots      | 2                          |            |   |        |   |   |   |    |   |   |
|            |                                   | Total Samples       | 24                         |            |   |        |   |   |   |    |   |   |
|            |                                   |                |                       |            |   |        |   |   |   |    |   |   |
|            |                                   | Protocol Generation |                       |            |   |        |   |   |   | $       | 791    |   |

|      |                    |               |   |                      |    |   |         |   |   |   |      |   |               |
|-----------|-------------------------|--------------------|--------|---------------------------|---------|--------|--------------|--------|--------|--------|-----------|--------|--------------------|
|      |                    |               |   |                      |    |   |         |   |   |   | Samples   |   | Cost per pullpoint |
| Pullpoint |                    |               |   |                      |    |   |         |   |   |   | per       |   | (Milestone Price)  |
| Months    |                    | 40°C / 75% RH |   | 25°C / 60% RH        |    |   | Microbiology |   | AET    |   | pullpoint |   |               |
| T=1       |                    | X                  |   | X                         |    |   |         |   |   |   | 4         | $      | 9,505              |
| T=3       |                    | X                  |   | X                         |    |   |         |   |   |   | 4         | $      | 9,505              |
| T=6       |                    | X                  |   | X                         |    |   |         |   |   |   | 4         | $      | 9,505              |
| T=9       |                    |               |   | X                         |    |   |         |   |   |   | 2         | $      | 6,380              |
| T=12      |                    |               |   | X                         |    |   | X            |   |   |   | 2         | $      | 7,593              |
| T=18      |                    |               |   | X                         |    |   |         |   |   |   | 2         | $      | 6,380              |
| T=24      |                    |               |   | X                         |    |   | X            |   |   |   | 2         | $      | 7,593              |
| T=36      |                    |               |   | X                         |    |   | X            |   |   |   | 2         | $      | 7,593              |
| T=48      |                    |               |   | X                         |    |   | X            |   |   |   | 2         | $      | 7,593              |
|      |                    |               |   | Summary Report Generation |    |   |         |   | $      | 1,130  |
|      |                    |               |   |                      |    |   |         |   |   |   |
|      |                    |               |   | Total                     |    |   |         |   | $      | 73,568 |
|      |                    |               |   | Material and Supply Fee:  |    |   |         |   | $      | 3,678  |
|      |                    |               |   |                      |    |   |
|      |                    |               |   |                      |    |   |         |   |   |   |
|      | BUDGET TOTAL            |               | USD    | $                         | 192,111 |
|      | Material and Supply Fee |               | USD    | $                         | 9,605   |
|      | GRAND TOTAL             |               | USD    | $                         | 201,716 |

|                                      |   |                                           |
|-------------------------------------------|--------|------------------------------------------------|
| COS Reference #: P-TRP-54564-R1-COS-01-R0 |   | Prana Biotechnology Limited                    |
| Issue Date: July 10, 2013                 |   | PBT2 Capsules - Phase I BE Batch Manufacturing |
| Confidential                              |   | Page 3 of 5                                    |

----

|    |                                                  |
|---------|-------------------------------------------------------|
| Part C: | Descriptions of work to be added to the Project Scope |

| 1. | Clinical Trial Material (CTM) Active Manufacturing |
|----|----------------------------------------------------|

|    |                                                                                                                                                                                                                                                                   |
|---------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| ● | 2 CTM Active batches (one 100 mg, one 250 mg strength), back-to-back manufacturing and testing                                                                                                                                                                         |
| ● | Approximately 5 kilograms per batch                                                                                                                                                                                                                                    |
| ● | Excipients released as per USP/NF/EP                                                                                                                                                                                                                                   |
| ● | Batch record, cGMP conditions & QA review                                                                                                                                                                                                                          |
| ● | Packaged into HDPE bottles (i.e. 35’s)                                                                                                                                                                                                                           |
| ● | In-Process Testing: Blend Homogeneity (one blend, 10 samples); Bulk & Tap Densities (including one sieve analysis), Flow Properties, Moisture (LOD or KF) and Physical Parameters (i.e. appearance, weight, weight variation) for beginning, middle and end of run |
| ● | Finished  Product Testing:  Potency &  Related  Substances;  Content Uniformity  (n=10); Dissolution (profile, n=6); Moisture (LOD or KF); Microbial Limit Testing (MLT)                               |

| 2. | Stability - CTM Active |
|----|------------------------|

|   |    |                                                                                       |
|--------|---------|--------------------------------------------------------------------------------------------|
|   | ● | 1, 3 and 6 months for 40°C ± 2°C / 75% ± 5% RH                         |
|   | ● | 1, 3, 6, 9, and 12 months for 30°C ± 2°C / 65% ± 5% RH*                |
|   | ● | 1, 3, 6, 9, 12, 18, 24, 36, and 48 months for 25°C ± 2°C / 60% ± 5% RH |

|                     |   |   |   |   |   |   |   |   |   |
|--------------------------|--------|--------|--------|--------|--------|--------|--------|--------|--------|
| Pullpoint Month          | 1      | 3      | 6      | 9      | 12     | 18     | 24     | 36     | 48     |
| Number of Samples Pulled | 4      | 4      | 4      | 2      | 2      | 2      | 2      | 2      | 2      |

|                                      |   |                                           |
|-------------------------------------------|--------|------------------------------------------------|
| COS Reference #: P-TRP-54564-R1-COS-01-R0 |   | Prana Biotechnology Limited                    |
| Issue Date: July 10, 2013                 |   | PBT2 Capsules - Phase I BE Batch Manufacturing |
| Confidential                              |   | Page 4 of 5                                    |

----

|                                           |
|------------------------------------------------|
| 0 single sample pullpoints (0 samples)         |
| 6 double sample pullpoints (12 samples)        |
| 3 three to four sample pullpoints (12 samples) |
| 0 more than five sample pullpoints (0 samples) |

| The following standard tests will be performed as part of the stability program: |
|----------------------------------------------------------------------------------|
|                                                                             |   |   |
|                                                                             | ● | Potency & related substances |
|                                                                             | ● | Physical appearance |
|                                                                             | ● | Moisture |
|                                                                             | ● | Dissolution (profile by HPLC) |
|                                                                             | ● | MLT (annually) |

|                |                           |               |
|---------------------|--------------------------------|--------------------|
| COS Revision Number | Description of Activities      | Overall Cost (USD) |
| R0                  | Phase I BE batch manufacturing | $201,716           |

|                                      |   |                                           |
|-------------------------------------------|--------|------------------------------------------------|
| COS Reference #: P-TRP-54564-R1-COS-01-R0 |   | Prana Biotechnology Limited                    |
| Issue Date: July 10, 2013                 |   | PBT2 Capsules - Phase I BE Batch Manufacturing |
| Confidential                              |   | Page 5 of 5                               |

----

----

|                                                                                                  |   |               |   |   |               |   |         |                     |   |                      |   |   |                                 |   |
|-------------------------------------------------------------------------------------------------------|--------|--------------------|--------|--------|--------------------|--------|--------------|--------------------------|--------|---------------------------|--------|--------|--------------------------------------|--------|
| BUDGET SUMMARY                                                                                        |
|                                                                                                  |   |               |   |   |               |   |
| THE FOLLOWING COSTS ARE ALL QUOTED IN:         USD  |   |               |   |   |               |   |
|                                                                                                  |   |               |   |   |               |   |
| STABILITY - PROTOTYPE BATCH                                                                           |   |               |   |   |               | USD    |         |
|                                                                                                  |   |               |   |   | ACTIVITY           |   |         |                     |   |                      |   |   | PRICE                                |   |
|                                                                                                  |   |               |   |   |               |   |         |                     |   |                      |   |   |                                 |   |
|                                                                                                  |   |               |   |   | Number of Lots     | 2      |         |                     |   |                      |   |   |                                 |   |
|                                                                                                  |   |               |   |   | Total Samples      | 6      |         |                     |   |                      |   |   |                                 |   |
|                                                                                                  |   |               |   |   |               |   |         |                     |   |                      |   |   |                                 |   |
| PullpointMonths                                                                                       |   | 40°C / 75% RH |   |   | 25°C / 60% RH |   | Microbiology | AET                      |   |  Samplesperpullpoint |   |   | Cost per pullpoint (Milestone Price) |   |
| T = 1                                                                                                 |   |               | X      |   |               |   | X            |                     |   |                      |   |   | 4                                    |   |   | $ | 11,060 |   |
| T = 2                                                                                       |   |               | X      |   |               |   |         |                     |   |                      |   |   | 2                                    |   |   | $ | 6,658 |   |
|                                                                                                  |   |               |   |   |               |   |         |                     |   |                      |   |   |                                 |   |   |   |   |   |
|                                                                                                  |   |               |   |   | Total              |   |         |                     |   |                      |   |   |                                 | $      | 17,718 |   |
|                                                                                                  |   |               |   |   |               |   |         | Material and Supply Fee: |   |                      |   |   |                                 |   | $ | 886 |   |
|                                                                                                  |   |               |   |   |               |   |         |                     |   |                      |   |   |                                 |   |   |   |   |   |

|                    |   |   |   |   |   |   |
|-------------------------|--------|--------|--------|--------|--------|--------|
| BUDGET TOTAL            |   | USD    |   |   | $      | 17,718 |   |
| Material and Supply Fee |   | USD    |   |   | $      | 886    |   |
| GRAND TOTAL             |   | USD    |   |   | $      | 18,604 |   |

|                                      |                        |
|-------------------------------------------|-----------------------------|
| COS Reference #: P-TRP-54564-R1-COS-02-R0 | Prana Biotechnology Limited |
| Issue Date: August 13, 2013               | PBT2 Capsules - Stability   |
| Confidential                              | Page 2 of 3                 |

----

| Part C: | Descriptions of work to be added to the Project Scope |
|---------|-------------------------------------------------------|

| 1. | Stability |
|----|-----------|

| ●                                      | 2 batches* under ICH conditions |
|----------------------------------------------|---------------------------------|
| *:4 batches to be tested in dissolution only |

|   |                                                            |
|--------|-----------------------------------------------------------------|
| =>  | 1 and 2 months for 40°C ± 2°C / 75% ± 5% RH |
| =>  | 1 months for 25°C ± 2°C / 60% ± 5% RH       |

| ● | Testing per sample: potency & related substances; dissolution (profile, n=6)*; physical (appearance, moisture) |
|---------|--------------------------------------------------------------------------------------------------------------------|

| Part D: | Descriptions of work to be Cancelled from the Project Scope |
|---------|-------------------------------------------------------------|

| Project Name: 11311 - Prana Biotechnology Ltd, - PBT2 Immediate Release Capsules |
|----------------------------------------------------------------------------------|
| Client Name: Prana Biotechnology Ltd.                                            |
| Product Name: PBT2 Immediate Release Capsules                                    |
| Currency: USD                                                                    |
|                                                                             |   |   |
| Task Name                                                                        |   | Fee |
| P-TRP-54564-R1                                                                   |   |   |
| STABILITY - T = 1 (Includes 5% Material and Supply Fee)                          |   | $9,169 |
| STABILITY - T = 2 (Includes 5% Material and Supply Fee)                          |   | $6,045 |
| Fee Summary:                                                                     |   | -$15,214 |

| COS Revision Number | Description of Activities | Overall Cost (USD) |
|---------------------|---------------------------|--------------------|
| R0                  | Stability                 | $3,390             |

|                                       |                        |
|--------------------------------------------|-----------------------------|
| COS Reference #: P-TRP-54564-R1 -COS-02-R0 | Prana Biotechnology Limited |
| Issue Date: August 13, 2013                | PBT2 Capsules - Stability   |
| Confidential                               | Page 3 of 3                 |

----

----

| Part B: | Descriptions of Work to be Added to the Project Scope |
|---------|-------------------------------------------------------|

| 1. | Clinical Trial Material (CTM) Active Manufacturing |
|----|----------------------------------------------------|

|    |                                                                                                                                                                                                                                                                   |
|---------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| ● | 2 CTM Active batches (one 100 mg, one 250 mg strength), back-to-back manufacturing and testing                                                                                                                                                                    |
| ● | Approximately 12 kilograms per batch                                                                                                                                                                                                                                   |
| ● | Excipients released as per USP/NF/EP                                                                                                                                                                                                                                   |
| ● | Batch record, cGMP conditions & QA review                                                                                                                                                                                                                          |
| ● | Packaged into HDPE bottles (i.e. 35’s)                                                                                                                                                                                                                           |
| ● | In-Process Testing: Blend Homogeneity (one blend, 10 samples); Bulk & Tap Densities (including one sieve analysis), Flow Properties, Moisture (LOD or KF) and Physical Parameters (i.e. appearance, weight, weight variation) for beginning, middle and end of run |
| ● | Finished Product Testing: Potency & Related Substances; Content Uniformity (n=10); Dissolution (profile, n=6); Moisture (LOD or KF); Microbial Limit Testing (MLT)                                                                                                 |

| 2. | Stability – Phase III CTM Active |
|----|---------------------------------------------|

|                                                     |                     |
|----------------------------------------------------------|--------------------------|
| Change of Scope COS-03-R0 to Proposal No. P-TRP-54564-R1 | Prana Biotechnology Ltd. |
| Issue Date: February 11, 2014                            | Page 2 of 6              |
| Confidential                                             |                     |

----

| ● | 1, 3 and 6 months for 40°C ± 2°C / 75% ± 5% RH                         |
|---------|--------------------------------------------------------------------------------------------|
| ● | 1, 3, 6, 9, and 12 months for 30°C ± 2°C / 65% ± 5% RH*                |
| ● | 1, 3, 6, 9, 12, 18, 24, 36, and 48 months for 25°C ± 2°C / 60% ± 5% RH |

| Pullpoint Month          | 1 | 3 | 6 | 9 | 12 | 18 | 24 | 36 | 48 |
|--------------------------|---|---|---|---|----|----|----|----|----|
| Number of Samples Pulled | 4 | 4 | 4 | 2 | 2  | 2  | 2  | 2  | 2  |

|    |                             |
|---------|----------------------------------|
| ● | Potency & related substances |
| ● | Physical appearance              |
| ● | Moisture                         |
| ● | Dissolution (profile by HPLC)    |
| ● | MLT (annually)                   |

|    |                                                                                       |
|---------|--------------------------------------------------------------------------------------------|
| ● | 1, 3 and 6 months for 40°C ± 2°C / 75% ± 5% RH                         |
| ● | 1, 3, 6, 9, and 12 months for 30°C ± 2°C / 65% ± 5% RH*                |
| ● | 1, 3, 6, 9, 12, 18, 24, 36, and 48 months for 25°C ± 2°C / 60% ± 5% RH |

|                                                     |                     |
|----------------------------------------------------------|--------------------------|
| Change of Scope COS-03-R0 to Proposal No. P-TRP-54564-R1 | Prana Biotechnology Ltd. |
| Issue Date: February 11, 2014                            | Page 3 of 6              |
| Confidential                                             |                     |

----

|                     |   |   |   |   |   |   |   |   |   |
|--------------------------|--------|--------|--------|--------|--------|--------|--------|--------|--------|
| Pullpoint Month          | 1      | 3      | 6      | 9      | 12     | 18     | 24     | 36     | 48     |
| Number of Samples Pulled | 2      | 2      | 2      | 1      | 1      | 1      | 1      | 1      | 1      |

|    |                             |
|---------|----------------------------------|
| ● | Potency & related substances |
| ● | Physical appearance              |
| ● | Moisture                         |
| ● | Dissolution (profile by HPLC)    |
| ● | MLT (annually)                   |

|                                                                                                                           |   |                                                                                                      |   |
|--------------------------------------------------------------------------------------------------------------------------------|--------|-----------------------------------------------------------------------------------------------------------|--------|
| Project Name: 11311 - Prana Biotechnology Ltd. - PBT2 Immediate Release Capsules                                               |   |                                                                                                      |   |
| Client Name: Prana Biotechnology Ltd.                                                                                          |   |                                                                                                      |   |
| Product Name: PBT2 Immediate Release Capsules                                                                                  |   |                                                                                                      |   |
| Currency: USD                                                                                                                  |   |                                                                                                      |   |
|                                                                                                                           |   |                                                                                                      |   |
| Task Name                                                                                                                      |   |                  Fee |   |
| P-TRP-54564-R1 -COS-01-R0                                                                                                      |   |                                                                                                      |   |
| CTM BATCHES (ED) - Back to Back Batch MZYM Manufacturing (Includes 5% Material and Supply Fee)                                 |   | $35,319                                                                                                   |   |
| CTM BATCHES (ED) - Back to Back Batch MZYS Packaging (Includes 5% Material and Supply Fee)                                     |   | $8,744                                                                                                    |   |
| CTM BATCHES (ED) - Back to Back Batch MZYM/MZYS Analytical Support (Includes 5% Material and Supply Fee)                       |   | $10,920                                                                                                   |   |
| STABILITY - CTM lots MZYS, MZYN - T= 1 Months (40°C/ 75% RH) (25°C / 60% RH) (Includes 5% Material and Supply Fee)   |   | $9,980                                                                                                    |   |
| STABILITY - CTM lots MZYS, MZYN - T= 3 Months (40°C/ 75% RH) (25°C / 60% RH) (Includes 5% Material and Supply Fee)   |   | $9,980                                                                                                    |   |
| STABILITY - CTM lots MZYS, MZYN - T = 6 Months (40°C / 75% RH) (25°C / 60% RH) (Includes 5% Material and Supply Fee) |   | $9,980                                                                                                    |   |
| STABILITY - CTM lots MZYS, MZYN - T= 9 Months (25°C / 60% RH) (Includes 5% Material and Supply Fee)                       |   | $6,699                                                                                                    |   |
| STABILITY - CTM lots MZYS, MZYN - T = 12 Months (25°C / 60% RH) (Includes 5% Material and Supply Fee)                     |   | $7,972                                                                                                    |   |
| STABILITY - CTM lots MZYS, MZYN - T = 18 Months (25°C / 60% RH) (Includes 5% Material and Supply Fee)                     |   | $6,699                                                                                                    |   |
| STABILITY - CTM lots MZYS, MZYN- T = 24 Months (25°C / 60% RH) (Includes 5% Material and Supply Fee)            |   | $7,972                                                                                                    |   |
| STABILITY - CTM lots MZYS, MZYN - T= 36 Months (25°C / 60% RH) (Includes 5% Material and Supply Fee)                      |   | $7,972                                                                                                    |   |
| STABILITY - CTM lots MZYS, MZYN - T = 48 Months (25°C / 60% RH) (Includes 5% Material and Supply Fee)                     |   | $7,972                                                                                                    |   |
| Fee Summary:                                                                                                                   |   | -$130,209                                                                                                 |   |

|                                                                                              |                                |
|---------------------------------------------------------------------------------------------------|-------------------------------------|
| Change of Scope COS-03-R0 to Proposal No. P-TRP-54564-R1Issue Date: February 11, 2014Confidential | Prana Biotechnology Ltd.Page 4 of 6 |

----

|                           |                                   |                                                                       |                |                       |            |   |   |   |   |   |    |   |   |
|--------------------------------|----------------------------------------|----------------------------------------------------------------------------|---------------------|----------------------------|-----------------|--------|--------|--------|--------|--------|---------|--------|--------|
|                           |                                   |           BUDGET SUMMARY |                |                       |            |   |   |   |   |   |
|                           |                                   |                                                                       |                |                       |            |   |   |   |   |   |
|                           | THE FOLLOWING COSTS ARE ALL QUOTED IN: | USD                                                                        |                |                       |            |   |   |   |   |   |
|                           |                                   |                                                                       |                |                       |            |   |   |   |   |   |
| 21.0 CTM BATCHES (LD)          |                                   |                                                                       |                |                       |            |   |   | USD    |   |
|                           |                                   |                                                                       | ACTIVITY            |                       | MILESTONE PRICE | PRICE  |
|                           |                                   |                                                                       |                |                       |            |   |
|                           | First Batch                            |                                                                       | Manufacturing       |                       |            | $      | 51,954 |   |   |   |    |   |
|                           |                                   |                                                                       | Packaging           |                       |            | $      | 17,377 |   |   |   |    |   |
|                           |                                   |                                                                       | Analytical Support  |                       |            | $      | 10,124 |   |   |   |    |   |
|                           |                                   |                                                                       |                | Total Per Batch            |            | $      | 79,455 |   |   |   |    |   |
|                           |                                   |                                                                       |                | 1 Batch TOTAL              |            |   |   |   |   | $      | 79,455  |   |
|                           | Back to Back Batch                     |                                                                       | Manufacturing       |                       |            | $      | 47,697 |   |   |   |    |   |
|                           |                                   |                                                                       | Packaging           |                       |            | $      | 15,780 |   |   |   |    |   |
|                           |                                   |                                                                       | Analytical Support  |                       |            | $      | 10,124 |   |   |   |    |   |
|                           |                                   |                                                                       |                | Total Per Batch            |            | $      | 73,601 |   |   |   |    |   |
|                           |                                   |                                                                       |                | 1 Back to Back Batch TOTAL |            |   |   |   |   | $      | 73,601  |   |
|                           |                                   |                                                                       |                |                       |            |   |   |   |   |   |    |   |
|                           |                                   |                                                                       |                |                       |            |   |   |   |   | $      | 153,056 |   |
|                           |                                   |                                                                       | Total               | Material and Supply Fee:   | $               | 7,653  |   |
|                           |                                   |                                                                       |                |                       |            |   |   |   |   |   |    |   |
| 24.0 STABILITY - Phase III CTM |                                   |                                                                       |                |                       |            |   |   | USD    |   |
|                           |                                   |                                                                       | ACTIVITY            |                       |            |   |   |   |   | PRICE  |
|                           |                                   |                                                                       |                |                       |            |   |   |   |   |   |    |   |
|                           |                                   |                                                                       | Number of Lots      | 2                          |            |   |   |   |   |   |    |   |   |
|                           |                                   |                                                                       | Total Samples       | 24                         |            |   |   |   |   |   |    |   |   |
|                           |                                   |                                                                       |                |                       |            |   |   |   |   |   |    |   |
|                           |                                   |                                                                       | Protocol Generation |                       |            |   |   |   |   | $      | 994     |   |

|                         |   |                    |   |                                                                                                                                                                                                                                                                                                                                                                                   |   |                     |   |         |   |    |   |                |   |                                |   |
|------------------------------|--------|-------------------------|--------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------------------------|--------|--------------|--------|---------|--------|---------------------|--------|-------------------------------------|--------|
| PullpointMonths              |   | 40C/ 75% RH             |   | 25C/ 60% RH                                                                                                                                                                                                                                                                                                                                                                            |   |                     |   | Microbiology |   | AET     |   | Samplesperpullpoint |   | Cost per pullpoint(Milestone Price) |
| T = 1                        |   | X                       |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   |         |   |    |   | 4                   | $      | 8,185                               |   |
| T = 3                        |   | X                       |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   |         |   |    |   | 4                   | $      | 8,185                               |   |
| T = 6                        |   | X                       |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   |         |   |    |   | 4                   | $      | 8,185                               |   |
| T = 9                        |   |                    |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   |         |   |    |   | 2                   | $      | 6,380                               |   |
| T = 12                       |   |                    |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   | X            |   |    |   | 2                   | $      | 7,593                               |   |
| T = 18                       |   |                    |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   |         |   |    |   | 2                   | $      | 6,380                               |   |
| T = 24                       |   |                    |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   | X            |   |    |   | 2                   | $      | 7,593                               |   |
| T = 36                       |   |                    |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   | X            |   |    |   | 2                   | $      | 7,593                               |   |
| T = 48                       |   |                    |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   | X            |   |    |   | 2                   | $      | 7,593                               |   |
|                         |   |                    |   | Summary Report Generation                                                                                                                                                                                                                                                                                                                                                              |   |                     |   |         |   |    | $      | 1,420               |   |
|                         |   |                    |   |                                                                                                                                                                                                                                                                                                                                                                                   |   |                     |   |         |   |    |   |                |   |                                |   |
|                         |   |                    |   | Total                                                                                                                                                                                                                                                                                                                                                                                  |   |                     |   |         |   |    | $      | 70,101              |   |
|                         |   |                    |   |                                                                                                                                                                                                                                                                                                                                                                                   |   | Material and Supply Fee: | $      | 3,505        |   |
|                         |   |                    |   |                                                                                                                                                                                                                                                                                                                                                                                   |   |                     |   |         |   |    |   |                |   |                                |   |
| 25.0 STABILITY - Phase I CTM |   |                    |   |                                                                                                                                                                                                                                                                                                                                                                                   |   |                     |   | USD          |   |
|                         |   |                    |   | ACTIVITY                                                              |   |                     |   |         |   |    |   | PRICE               |   |
|                         |   |                    |   |                                                                                                                                                                                                                                                                                                                                                                                   |   |                     |   |         |   |    |   |                |   |
|                         |   |                    |   | Number of Lots                                                     1                                     |   |                     |   |         |   |    |   |                |   |
|                         |   |                    |   | Total Samples                                                        12                        |   |                     |   |         |   |    |   |                |   |
|                         |   |                    |   |                                                                                                                                                                                                                                                                                                                                                                                   |   |                     |   |         |   |    |   |                |   |                                |   |
| PullpointMonths              |   | 40C / 75% RH            |   | 25C/ 60% RH                                                                                                                                                                                                                                                                                                                                                                            |   |                     |   | Microbiology |   | AET     |   | Samplesperpullpoint |   | Cost per pullpoint(Milestone Price) |
| T = 1                        |   | X                       |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   |         |   |    |   | 2                   | $      | 6,380                               |   |
| T = 3                        |   | X                       |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   |         |   |    |   | 2                   | $      | 6,380                               |   |
| T = 6                        |   | X                       |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   |         |   |    |   | 2                   | $      | 6,380                               |   |
| T = 9                        |   |                    |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   |         |   |    |   | 1                   | $      | 5,421                               |   |
| T = 12                       |   |                    |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   | X            |   |    |   | 1                   | $      | 6,065                               |   |
| T = 18                       |   |                    |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   |         |   |    |   | 1                   | $      | 5,421                               |   |
| T = 24                       |   |                    |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   | X            |   |    |   | 1                   | $      | 6,065                               |   |
| T = 36                       |   |                    |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   | X            |   |    |   | 1                   | $      | 6,065                               |   |
| T = 48                       |   |                    |   | X                                                                                                                                                                                                                                                                                                                                                                                      |   |                     |   | X            |   |    |   | 1                   | $      | 6,065                               |   |
|                         |   |                    |   |                                                                                                                                                                                                                                                                                                                                                                                   |   |                     |   |         |   |    |   |                |   |                                |   |
|                         |   |                    |   | Total                                                                                                                                                                                                                                                                                                                                                                                  |   |                     |   |         |   |    | $      | 54,242              |   |
|                         |   |                    |   |                                                                                                                                                                                                                                                                                                                                                                                   |   | Material and Supply Fee: | $      | 2,712        |   |
|                         |   |                    |   |                                                                                                                                                                                                                                                                                                                                                                                   |   |                     |   |         |   |    |   |                |   |                                |   |
|                         |   |                    |   |                                                                                                                                                                                                                                                                                                                                                                                   |   |                     |   |         |   |    |   |                |   |                                |   |
|                         |   | BUDGET TOTAL            |   |                                                                                                                                                                                                                                                                                                                                                                                   |   |                     |   | USD          | $      | 277,399 |   |
|                         |   | Material and Supply Fee |   |                                                                                                                                                                                                                                                                                                                                                                                   |   |                     |   | USD          | $      | 13,870  |   |
|                         |   | GRAND TOTAL             |   |                                                                                                                                                                                                                                                                                                                                                                                   |   |                     |   | USD          | $      | 291,269 |   |

|                                                                                              |                                |
|---------------------------------------------------------------------------------------------------|-------------------------------------|
| Change of Scope COS-03-R0 to Proposal No. P-TRP-54564-R1Issue Date: February 11, 2014Confidential | Prana Biotechnology Ltd.Page 5 of 6 |

----

| COS Revision Number | Description of Activities | Overall Cost |
|---------------------|---------------------------|--------------|
| R0                  | CTM manufacturing         | $161,060 USD |

|                                                                                              |                                |
|---------------------------------------------------------------------------------------------------|-------------------------------------|
| Change of Scope COS-03-R0 to Proposal No. P-TRP-54564-R1Issue Date: February 11, 2014Confidential | Prana Biotechnology Ltd.Page 6 of 6 |

----

----

| 1. | Analytical Services |
|----|---------------------|

|    |                                                                                          |
|---------|-----------------------------------------------------------------------------------------------|
| ● | Product potency and related substances assay (phase III addendum method validation)           |
| ● | Product dissolution assay – profile by HPLC (phase III addendum method validation) |

| ● | Accuracy (related substances only) |
|---------|------------------------------------|
| ● | Robustness                         |

|                                                     |   |                     |
|----------------------------------------------------------|--------|--------------------------|
| Change of Scope COS-04-R0 to Proposal No. P-TRP-54564-R1 |   | Prana Biotechnology Ltd. |
| Issue Date: March 3, 2014                           |   | Page 2 of 3              |
| Confidential                                             |   |                     |

----

|                                                                                  | BUDGET  SUMMARY                                                                                  |
|---------------------------------------------------------------------------------------|-------------------------------------------------------------------------------------------------------|
|                                                                                  |                                                                                                  |
|                                                                                  | THE FOLLOWING COSTS ARE ALL QUOTED IN:          USD |
|                                                                                  |                                                                                                  |
|      1.0     ANALYTICAL DEVELOPMENT |                                                                                                  |   |   | USD |
|                                                                                  | ACTIVITY                                                                                              |   |   | PRICE |
|                                                                                  |                                                                                                  |   |   |   |
|                                                                                  | Product Potency and Related Substances Assay (Method Validation Phase III)                            |   | $ | 13,686 |
|                                                                                  |                                                                                                  |   |   |   |
|                                                                                  | IR - Product Dissolution Assay by HPLC (Method Validation Phase III)                                  |   | $ | 13,686 |
|                                                                                  |                                                                                                  |   |   |   |
|                                                                                  | Total                                                                                                 |   | $ | 27,372 |
|                                                                                  | Material and Supply Fee:                                                                              |   | $  | 1,369 |
|                                                                                  |                                                                                                  |   |   |   |   |
|                                                                                  | BUDGET TOTAL                                                                                          | USD |   | $ | 27,372 |
|                                                                                  | Material and Supply Fee                                                                               | USD |   | $ | 1,369 |
|                                                                                  | GRAND TOTAL                                                                                           | USD |   | $ | 28,741 |

| COS Revision Number    | Description of Activities | Overall Cost |
|---------------------------------------|---------------------------|--------------|
| R0                                    | Analytical services       | $28,741 USD  |

|                                                     |   |                     |
|----------------------------------------------------------|--------|--------------------------|
| Change of Scope COS-04-R0 to Proposal No. P-TRP-54564-R1 |   | Prana Biotechnology Ltd. |
| Issue Date: March 3, 2014                           |   | Page 3 of 3         |
| Confidential                                             |   |                     |

----

----

| 1. | Environmental, Health and Safety Assessment |
|----|---------------------------------------------|

|   |    |                                                                                              |
|--------|---------|---------------------------------------------------------------------------------------------------|
|   | ● | To ensure the correct handling, storage and safety instructions are generated for the PBT434 API. |

|   |    |                                                    |
|--------|---------|---------------------------------------------------------|
|   | ● | EH&S safety categorisation letter for the API. |

| 2. | CTM Manufaturing Report |
|----|-------------------------|

|                                                     |                     |
|----------------------------------------------------------|--------------------------|
| Change of Scope COS-06-R0 to Proposal No. P-TRP-54564-R1 | Prana Biotechnology Ltd. |
| Issue Date: April 11, 2014                          | Page 2 of 3              |
| Confidential                                             |                     |

----

| BUDGET SUMMARY |
|----------------|
|           |   |   |   |   |   |
|           | THE FOLLOWING COSTS AREALL QUOTED IN:         USD |   |   |   |   |
|           |   |   |   |   |   |
|           | ENVIRONMENTAL HEALTH AND SAFETY |   |   |   | USD |
|           | ACTIVITY |   |   |   | PRICE |
|           | EH&S Assessment |   |   | $ | 2,000 |
|           | CTM BATCHES (LD) |   |   |   | USD |
|           | ACTIVITY | MILESTONE PRICE |   |   | PRICE |
|           | Manufacturing Report |   |   | $ | 8,600 |
|           |   |   |   |   |   |
|           | Total |   |   | $ | 8,600 |
|           |
|           | BUDGET TOTAL | USD |   | $ | 10,600 |

| COS Revision Number | Description of Activities  | Overall Cost |
|---------------------|----------------------------|--------------|
| R0                  | EH&S and manufacturing | $10,600 USD  |

|                                                     |                     |
|----------------------------------------------------------|--------------------------|
| Change of Scope COS-06-R0 to Proposal No. P-TRP-54564-R1 | Prana Biotechnology Ltd. |
| Issue Date: April 11, 2014                          | Page 3 of 3         |
| Confidential                                             |                     |

----

----

|    |     |
|---------|----------|
| Part A: | Overview |

|    |                                                  |
|---------|-------------------------------------------------------|
| Part B: | Descriptions of Work to be Added to the Project Scope |

|    |    |
|---------|---------|
| Part D: | Pricing |

|           |                                   |                                                        |                     |   |   |   |   |   |   |   |   |   |
|----------------|----------------------------------------|-------------------------------------------------------------|--------------------------|--------|--------|--------|--------|--------|--------|--------|--------|--------|
| BUDGET SUMMARY |
|           |                                   |                                                        |                     |   |   |   |   |
|           | THE FOLLOWING COSTS ARE ALL QUOTED IN: | USD                                                         |                     |   |   |   |   |
|           |                                   |                                                        |                     |   |   |   |   |
|           | ANALYTICAL DEVELOPMENT                 |                                                        |                     |   |   |   | USD    |
|           |                                   | ACTIVITY                                                    |                     |   |   | PRICE  |
|           |                                   |                                                        |                     |   |   |   |   |   |   |   |   |
|           |                                   | IR - Product Dissolution Assay by HPLC (Method Development) |                     |   |   |   |   | $      | 9,652  |   |
|           |                                   |                                                        |                     |   |   |   |   |   |   |   |   |
|           |                                   | Total                                                       |                     |   |   |   |   |   | $      | 9,652  |   |
|           |                                   |                                                        | Material and Supply Fee: |   | $      | 483    |   |

|   |                    |   |   |   |   |   |   |   |   |   |
|--------|-------------------------|--------|--------|--------|--------|--------|--------|--------|--------|--------|
|   | BUDGET TOTAL            |   | USD    | $      | 9,652  |
|   | MATERIAL AND SUPPLY FEE |   | USD    | $      | 483    |
|   | GRAND TOTAL             |   | USD    | $      | 10,135 |

|                                                     |   |                     |
|----------------------------------------------------------|--------|--------------------------|
| Change of Scope COS-08-R0 to Proposal No. P-TRP-54564-R1 |   | Prana Biotechnology Ltd. |
| Issue Date: August 22, 2014                              |   | Page 2 of 3              |
| Confidential                                             |   |                     |

----

|                |                      |         |
|---------------------|---------------------------|--------------|
| COS Revision Number | Description of Activities | Overall Cost |
| R0                  | Analytical development    | $10,135 USD  |

|                                                     |   |                     |
|----------------------------------------------------------|--------|--------------------------|
| Change of Scope COS-08-R0 to Proposal No. P-TRP-54564-R1 |   | Prana Biotechnology Ltd. |
| Issue Date: August 22, 2014                              |   | Page 3 of 3         |
| Confidential                                             |   |                     |

----

----