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|   |
|--------|

| Project item(Sub-Project)                                  |   |   | ResponsibleParty |   |   | MilestonePayment |   |   | Timeline                                                                        |
|------------------------------------------------------------|--------|--------|------------------|--------|--------|------------------|--------|--------|---------------------------------------------------------------------------------|
| 1-Completion ofProcess Developmentwork (towardsfiltration) |   |   | Dr.Reddy’s |   |   | USD 45,000       |   |   | Commence April1st 2013, “startdate”. Milestonepayment oncompletion. |

| Project item(Sub-Project)                                                                              |   |   | ResponsibleParty |   |   | MilestonePayment |   |   | Timeline                                                                        |
|--------------------------------------------------------------------------------------------------------|--------|--------|------------------|--------|--------|------------------|--------|--------|---------------------------------------------------------------------------------|
| 1(a)- Completion ofProcess Developmentwork (towardsfiltration) till stage 4(CDDQ-4)                    |   |   | Dr.Reddy’s |   |   | USD 36,000       |   |   | Commence Aprillst 2013, “startdate”. Milestonepayment oncompletion. |
| 1(b)- Completion ofProcess Developmentwork (towardsfiltration) from stage 4(CDDQ-4) to stage 5(CDDQ-5) |   |   | Dr.Reddy’s |   |   | USD 9,000        |   |   | Commence Aprillst 2013, “startdate”.Milestonepayment oncompletion.  |

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|                                   |                            |              |
|----------------------------------------|---------------------------------|-------------------|
| Signed for and on behalf of            | Signed for and on behalf of     |
| Dr. Reddy’s Laboratories Limited | Prana Biotechnology Ltd.        |
|                                   |                            |
|                                        |                                 |
|                                   |                            |
| Signature                              | Signature                       |
| Name: Manoj Mehrotra                   | Name: Dianne Angus              |
|                                   |                            |              |
|                                        |                            |                   |
| Witness Signature                      |                            | Witness Signature |
| Witness Name: Animesh Kondiparthy      | Witness Name: Elisabeth Gautier |

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|   |                                                                                                                                                          |   |
|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|
|   |                                                                                                                                                          |   |
|   | This amendment will include the following amended clauses in the above mentioned agreement and will be in effect from 31st August 2013.                       |   |
|   |                                                                                                                                                          |   |
|   | 1. Terms to the amendment would remain as same as that of MSA Commencement Date 5th April’13                                                       |   |
|   |                                                                                                                                                          |   |
|   | The following project item (Sub-Project) in Appendix A (Project works and time table section) is added with the following activities as additional section -8 |   |
|   |                                                                                                                                                          |   |
|   | Sub project-section -8 in Appendix A (project works and time table section) is added with the additional line items as described below                        |   |

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|   |                                                   |                                                                                                                                                                                                                                                                                                                        |   |                                                                                                 |   |                                                          |   |                                               |   |                                     |
|--------|--------------------------------------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|------------------------------------------------------------------------------------------------------|--------|---------------------------------------------------------------|--------|----------------------------------------------------|--------|------------------------------------------|
|   | Sr.No.                                                 |                                                                                                                                                                                                                                                                                                                        |   | Project item (Sub-Project) Appendix A                                                                |   | ResponsibleParty                                              |   | Milestone Payment inUSD on completion of line item |   | Expected /EstimatedTimeline andinvoicing |
|   | 8. EOP2, analytical & crystallization work package |
|   | a.                                                     |                                                                                                                                                                                                                                                                                                                        | l      | Analysis of IDT batches & sharing required set of data as per the revised Assay & RS methods |   | Dr. Reddy’s & Prana (sample to be provided by Prana |   | 2,000                                              |   |                                     |
|   |                                                   |                                                                                                                                                                                                                                                                                                                        |   |                                                                                                 |   |                                                          |   |                                               |
|   | l                                                      | Comparing physical properties for all key API batches Batch Number 1457(2011 campaign), 1433(current campaign) are plant scale batches and DA1020702.1 is IDT batch. These batches will be analyzed & compared for physical properties e.g. PSD, DSC, XRPD and bulk density (if sufficient quantity is available)  |   | Dr. Reddy’s & Prana (sample to be provided by Prana)                                       |   | 6,000                                                         |   | Sep’14                                       |
|   | l                                                      | Expanding specifications of CDDQ-3 as a regulatory starting material & related analytical work.                                                                                                                                                                                                                         |   |                                                                                                 |   |                                                          |   |                                               |

|   |   |   |                                                                                                                                                                                                                                 | Specification development as per requirement of Regulatory starting material                                                                                                                                                                                                                                                                           |                          | Dr. Reddy’s & Prana |   | 10,000 |           |         |
|--------|--------|--------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|-------------------------------|-------------------------------|--------|--------|----------------|--------------|
|   |   |   |                                                                                                                                                                                                                                 |                                                                                                                                                                                                                                                                                                                                                   |                          |                          |   |   |           |         |
|   |   |   | l                                                                                                                                                                                                                                    | Part Compilation of data as part of CMC package for EOP2 meetingCreating batch history for CDDQ-3,4,5i-impurity profiling, showing equivalency to the earlier material, method. Old batches may not be available, however impurity profile would be created for all the batches manufactured now onwards – Compiled data would be presented |                          | Dr. Reddy’s & Prana |   | 5,000  |           |         |
|   |   |   |                                                                                                                                                                                                                                 |                                                                                                                                                                                                                                                                                                                                                   |                          |                          |   |   |           |         |
|   | b.     |   | CMC summary for EOP2:                                                                                                                                                                                                                |                                                                                                                                                                                                                                                                                                                                                   |                          |                          |   |   |           |
|   |   |   |                                                                                                                                                                                                                                 |                                                                                                                                                                                                                                                                                                                                                   |                          |                          |   |   |           |
|   |   | l      | Expanding specifications of CDDQ-3 as a regulatory starting material & related analytical work- Method development and validation for related substances by HPLC and assay by HPLC – Compiled data would be presented |                                                                                                                                                                                                                                                                                                                                                   | Dr. Reddy’s & Prana |                          | 13,000 |   | Sept’ 14 |
|   |   |   |                                                                                                                                                                                                                                 |                                                                                                                                                                                                                                                                                                                                                   |                          |                          |   |   |           |
|   |   | l      | Analytical support for crystallization development work including PSD analysis- Compiled data would be presented                                                                                                                     |                                                                                                                                                                                                                                                                                                                                                   | Dr. Reddy’s & Prana |                          | 14,000 |   |           |
|   |   |   |                                                                                                                                                                                                                                 |                                                                                                                                                                                                                                                                                                                                                   |                          |                          |   |   |           |         |
|   | c.     |   | l                                                                                                                                                                                                                                    | Material Generation for Crystallization work                                                                                                                                                                                                                                                                                                           |                          | Dr. Reddy’s             |   | 5,500  |           | Oct’14 |
|   |   | l      | Analysis for the support on Crystallization studies for the lab samples                                                                                                                                                              |                                                                                                                                                                                                                                                                                                                                                   | Dr. Reddy’s             |                          | 13,500 |   |
|   |   |   |                                                                                                                                                                                                                                 |                                                                                                                                                                                                                                                                                                                                                   |                          |                          |   |   |           |         |
|   | d.     |   | l                                                                                                                                                                                                                                    | Analysis of Optimized Samples and Report Finalization for Crystallization work                                                                                                                                                                                                                                                                         |                          | Dr. Reddy’s             |   | 8000   |           | Nov’14 |

|                                    |                                                                                                   |
|-----------------------------------------|--------------------------------------------------------------------------------------------------------|
| Signed for and on behalf of             | Signed for and on behalf of                                                                            |
| Dr. Reddy’s Laboratories Limited  | Prana Biotechnology Ltd.                                                                               |
|     25th Sept 2014       |    2/9/14.                                                                                   |
| Signature                               | Signature                                                                                              |
| Name: Anurag Roy                        | Name: Dianne Angus                                                                                     |
|    25th Sept 2014             |                                                                                                        |
|                                    |                                                                                                   |
| Witness Signature                       | Witness Signature                                                                                      |
| Witness Name: Suresh Kumar Ramachandran | Witness Name: Elisabeth Gautier          2 Sept 2014 |

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