Initial to indicate certification as to information on this page (full text of certification is on page one) 

13. Phone Number

10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any 

knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.

12. Name of Company

11. Date

OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________

K-I CHEMICAL U.S.A. INC

11 MARTINE AVE, SUITE 1460

WHITE PLAINS, NY 10606

Environmental Fate Data Requirements (Conventional 

Chemical)

835.4100

835.4300

850.3030

850.3040

SS-1228

SS-1253

SS-1254

SS-1311

Aerobic soil metabolism

Aerobic aquatic metabolism

Honey bee toxicity of residues on foliage

Field testing for pollinators

Larval honey bee acute oral toxicity

Larval honeybee chronic oral toxicity

Adult honeybee chronic oral toxicity

Honey bee adult acute oral toxicity

N/A - Bispyribac-sodium

Chemical # and Name: 078906

Bispyribac-sodium

18-Mar-2016

GENERIC

ID # GDCI-078906-1470

T,S,W,Y,Z,R,AA,B,A,P

T,S,W,Y,Z,R,AA,B,A,P

T,S,W,Y,Z,R,AA,B,A,P

T,S,W,Y,Z,R,AA,B,A,P

T,S,W,Y,Z,R,AA,B,A,P

T,S,W,Y,Z,R,AA,B,A,P

T,S,W,Y,Z,R,AA,B,A,P

T,S,W,Y,Z,R,AA,B,A,P

TGAI

PAIRA; TGAI

TEP

TEP

TGAI

TGAI

TGAI

TGAI

24

24

12

24

12

24

24

12

Page 1 of 

(4)

(5)

(2)

(1, 7, 8, 15)

(13)

(10, 13, 15)

(9, 15)

(3)

Y

N

N

N

Y

Y

Y

N

2
Date

OMB Approval 2070-0174 

EPA FORM 6300-3

United States Environmental Protection Agency 

Washington, D.C. 20460

REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE

INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline

Requirement

Number

5. Study Title Progress 

Reports

1 2 3

6. Use 

Pattern

7. Test 

Substance

8. Time

Frame 

(Months)

9. Registrant

Response

P

R

O

T

O

C

O

L

1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

K-I CHEMICAL U.S.A. INC

11 MARTINE AVE, SUITE 1460

WHITE PLAINS, NY 10606

SS-1316

SS-1338

Field trial of residues in pollen and nectar

Pollinator Tier 2 Semi-Field Testing

N/A - Bispyribac-sodium

Chemical # and Name: 078906

Bispyribac-sodium

18-Mar-2016

GENERIC

ID # GDCI-078906-1470

T,S,W,Y,Z,R,AA,B,A,P

T,S,W,Y,Z,R,AA,B,A,P

TEP

TEP

12

24

Page 2 of 

(12, 14, 15)

(6, 11, 15)

N

N

2
United States Environmental Protection Agency 

Washington, D.C. 20460

FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS

N/A - Bispyribac-sodium

GDCI-078906-1470

1

2

3

Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active 

Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

USEPA. 2012c. Field Testing for Pollinators. Ecological Effects Test Guidelines OCSPP 850.3040. EPA 712-C-017. 

Web.http://nepis.epa.gov/Exe/ZyNET.exe/P100IRF2.TXT?ZyActionD=ZyDocument&Client=EPA&Index=2011+Thru+2015&Docs=&Query=&Time=&EndTime=&SearchMethod=1&TocRestrict=n&Toc

=&TocEntry=&QField=&QFieldYear=&QFieldMonth=&QFieldDay=&IntQFieldOp=0&ExtQFieldOp=0&XmlQuery=&File=D%3A%5Czyfiles%5CIndex%20Data%5C11thru15%5CTxt%5C00000010%5CP

100IRF2.txt&User=ANONYMOUS&Password=anonymous&SortMethod=h%7C-

&MaximumDocuments=1&FuzzyDegree=0&ImageQuality=r75g8/r75g8/x150y150g16/i425&Display=p%7Cf&DefSeekPage=x&SearchBack=ZyActionL&Back=ZyActionS&BackDesc=Results%20p

age&MaximumPages=1&ZyEntry=1

USEPA. 2012b. Honey Bee Toxicity of Residues on Foliage. Ecological Effects Test Guidelines OCSPP 850.3030. EPA 712-C-018. Web. http://www.regulations.gov/#!documentDetail;D=EPA-HQOPPT-2009-0154-0017

USEPA. 2012a. Honey Bee Acute Oral Toxicity Ecological Effects Test Guidelines OECD 213. Web:

http://nepis.epa.gov/Exe/ZyNET.exe/P100IRF8.TXT?ZyActionD=ZyDocument&Client=EPA&Index=2011+Thru+2015&Docs=&Query=&Time=&EndTime=&SearchMethod=1&TocRestrict=n&Toc=&To

cEntry=&QField=&QFieldYear=&QFieldMonth=&QFieldDay=&IntQFieldOp=0&ExtQFieldOp=0&XmlQuery=&File=D%3A%5Czyfiles%5CIndex%20Data%5C11thru15%5CTxt%5C00000010%5CP100I

RF8.txt&User=ANONYMOUS&Password=anonymous&SortMethod=h%7C-

&MaximumDocuments=1&FuzzyDegree=0&ImageQuality=r75g8/r75g8/x150y150g16/i425&Display=p%7Cf&DefSeekPage=x&SearchBack=ZyActionL&Back=ZyActionS&BackDesc=Results%20p

age&MaximumPages=1&ZyEntry=1&SeekPage=x&ZyPURL

Case # and Name:

DCI Number:

Page: 1 of

Footnotes: The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. 

These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement.

Use Categories Key:

A - Terrestrial food crop

B - Terrestrial feed crop

P - Aquatic nonfood crop

R - Agricultural premises and equipment

S - Food handling/storage establishments premises

and equipment

T - Commercial, institutional and industrial premises

and equipment

W - Human drinking water systems

Y - Industrial processes and water systems - 

once through 

AA - Antifouling coatings

Z - Industrial processes and water systems - not 

once through

2
United States Environmental Protection Agency 

Washington, D.C. 20460

FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS

N/A - Bispyribac-sodium

GDCI-078906-1470

4

5

6

7

8

9

10

11

12

13

14

15

Key: Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active 

Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Three more soils are required to satisfy this guideline.

This study must be done on two sediments.

The need for a semi-field test for pollinators (i.e., either a field-feeding test or a tunnel test) will be determined based upon the results of lower tier tests and/or other lines of evidence, and the 

need for a refined pollinator risk assessment.

The need for a field test for pollinators will be determined based upon lower-tiered tests and/or other lines of data and the need for a refined pollinator risk assessment.

See information and guidance identified in the EPA documents, (i) USEPA. 2012. White Paper in Support of the Proposed Risk Assessment Process for Bees. Submitted to the FIFRA Scientific 

Advisory Panel for Review and Comment September 11 to 14, 2012. Office of Chemical Safety and Pollution Prevention Office of Pesticide Programs Environmental Fate and Effects Division, 

Environmental Protection Agency, Washington DC; Environmental Assessment Directorate, Pest Management Regulatory Agency, Health Canada, Ottawa, CN; California Department of Pesticide 

Regulation http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2012-0543-0004; (ii) 2014 Guidance for Assessing Pesticide Risks to Bees. Office of Pesticide Programs United States 

Environmental Protection Agency, Health Canada Pest Management Regulatory Agency, California Department of Pesticide Regulation. June 19, 2014. 

http://www2.epa.gov/sites/production/files/2014-06/documents/pollinator_risk_assessment_guidance_06_19_14.pdf.

OECD has not yet finalized test guidelines for chronic studies, and efforts are underway to develop standardized guidelines for assessing the effects from chronic exposure to adult and larvae 

in the laboratory. Discussion of the study design elements for the 10-day adult toxicity test can be found in Appendix O of the European Food Safety Authority (EFSA) guidance document: 

EFSA. Guidance on the risk assessment of plant protection products on bees (Apis mellifera, Bombus spp. and solitary bees. EFSA Journal 2013;11(7):3295, 266 pp. 

doi:10.2903/j.efsa.2013.3295. 

Available online at: http://www.efsa.europa.eu/en/efsajournal/doc/3295.pdf

OECD has not yet finalized test guidelines for chronic studies with honey bee larvae. OECD draft guidance has is being developed, see OECD 2013b. OECD Draft Guidance Document Honey Bee

(Apis mellifera) Larval Toxicity Test, Repeated Exposure. http://www.oecd.org/env/ehs/testing/Draft_GD_honeybees_rep_exp_for_2nd_CR_25_November_2013.pdf

OECD 75 Guidance document on the Honey Bee (Apis mellifera L.) Brood Test under Semi-field conditions. Web: http://www.oecd.org/officialdocuments/

publicdisplaydocumentpdf/?cote=env/jm/mono(2007)22&doclanguage=en

Measurements of residues in the pollen/nectar are needed based upon lower-tiered tests and/or other lines of evidence, and the need for a refined pollinator risk assessment.

In some cases, information pertaining to acute toxicity to honey bee larvae may be obtained with the chronic honey bee larvae test thereby negating the need for separate acute and chronic 

larval toxicity tests.

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation. The following elements should be considered when developing study protocol(s) for the monitoring of 

residues in pollen/nectar.

a. Consideration of the range of application methods and environmental conditions (e.g., soil and hydric regimes) that the target crop(s) may be under.

b. Consideration of the attractiveness of the selected crop to pollinators

c. Consideration of a collection schedule sufficient to allow for an understanding of the character of residues, in the pollen/nectar and/or plant tissues, over time.

d. Consideration of data sufficient to determine whether residues of the active ingredient and/or degradation product(s) accumulates in soil and is/are bioavailable for plant to uptake in a 

following planting, and therefore result in potential exposure to pollinators.

e. Consideration of the market proportion of the selected target crop(s).

A study protocol must be submitted to, and reviewed by EPA, prior to study initiation.

Case # and Name:

DCI Number:

Page: 2 of 2