Initial to indicate certification as to information on this page (full text of certification is on page one) 13. Phone Number 10. Certification: I certify that the statements made on this form and all attachments are true, accurate, and complete. I acknowledge that any knowingly false or misleading statement may be punishable by fine, imprisonment or both under applicable law.
12. Name of Company 11. Date OMB Approval 2070-0174 EPA FORM 6300-3 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number

Signature and Title of Company's Authorized Representative _________________________________________________________________ K-I CHEMICAL U.S.A. INC 11 MARTINE AVE, SUITE 1460 WHITE PLAINS, NY 10606

Environmental Fate Data Requirements (Conventional Chemical) 835.4100 835.4300

850.3030 850.3040 SS-1228 SS-1253 SS-1254 SS-1311 Aerobic soil metabolism

Aerobic aquatic metabolism

Honey bee toxicity of residues on foliage Field testing for pollinators Larval honey bee acute oral toxicity Larval honeybee chronic oral toxicity Adult honeybee chronic oral toxicity Honey bee adult acute oral toxicity N/A - Bispyribac-sodium Chemical # and Name: 078906 Bispyribac-sodium 18-Mar-2016 GENERIC ID # GDCI-078906-1470

T,S,W,Y,Z,R,AA,B,A,P T,S,W,Y,Z,R,AA,B,A,P

T,S,W,Y,Z,R,AA,B,A,P T,S,W,Y,Z,R,AA,B,A,P T,S,W,Y,Z,R,AA,B,A,P T,S,W,Y,Z,R,AA,B,A,P T,S,W,Y,Z,R,AA,B,A,P T,S,W,Y,Z,R,AA,B,A,P TGAI PAIRA; TGAI

TEP TEP TGAI TGAI TGAI TGAI 24 24

12 24 12 24 24 12 1 of Page

(4) (5)

(2) (1, 7, 8, 15) (13) (10, 13, 15) (9, 15) (3) Y N

N N Y Y Y N 2Date OMB Approval 2070-0174 EPA FORM 6300-3 

### United States Environmental Protection Agency

Washington, D.C. 20460 REQUIREMENTS STATUS AND REGISTRANT'S RESPONSE INSTRUCTIONS: Please type or print in ink. Please read carefully the attached instructions and supply the information requested on this form. Use additional sheet(s) if necessary.

4. Guideline Requirement Number 5. Study Title Progress Reports



### 2 3 1 6. Use

Pattern 7. Test Substance 8. Time Frame (Months) 9. Registrant

Response P R O T O C O L 1. Company Name and Address 2. Case # and Name 3. Date and Type of DCI and Number K-I CHEMICAL U.S.A. INC 11 MARTINE AVE, SUITE 1460 WHITE PLAINS, NY 10606

SS-1316 SS-1338 Field trial of residues in pollen and nectar

Pollinator Tier 2 Semi-Field Testing N/A - Bispyribac-sodium Chemical # and Name: 078906 Bispyribac-sodium 18-Mar-2016 GENERIC ID # GDCI-078906-1470

T,S,W,Y,Z,R,AA,B,A,P T,S,W,Y,Z,R,AA,B,A,P TEP TEP 12 24 2of Page

(12, 14, 15) (6, 11, 15) N

N 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Bispyribac-sodium GDCI-078906-1470

1

2 3 Key:Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

USEPA. 2012c. Field Testing for Pollinators. Ecological Effects Test Guidelines OCSPP 850.3040. EPA 712-C-017. Web.http://nepis.epa.gov/Exe/ZyNET.exe/P100IRF2.TXT?ZyActionD=ZyDocument&Client=EPA&Index=2011+Thru+2015&Docs=&Query=&Time=&EndTime=&SearchMethod=1&TocRestrict=n&Toc =&TocEntry=&QField=&QFieldYear=&QFieldMonth=&QFieldDay=&IntQFieldOp=0&ExtQFieldOp=0&XmlQuery=&File=D%3A%5Czyfiles%5CIndex%20Data%5C11thru15%5CTxt%5C00000010%5CP 100IRF2.txt&User=ANONYMOUS&Password=anonymous&SortMethod=h%7C- &MaximumDocuments=1&FuzzyDegree=0&ImageQuality=r75g8/r75g8/x150y150g16/i425&Display=p%7Cf&DefSeekPage=x&SearchBack=ZyActionL&Back=ZyActionS&BackDesc=Results%20p age&MaximumPages=1&ZyEntry=1USEPA. 2012b. Honey Bee Toxicity of Residues on Foliage. Ecological Effects Test Guidelines OCSPP 850.3030. EPA 712-C-018. Web. http://www.regulations.gov/#!documentDetail;D=EPA-HQOPPT-2009-0154-0017 USEPA. 2012a. Honey Bee Acute Oral Toxicity Ecological Effects Test Guidelines OECD 213. Web: http://nepis.epa.gov/Exe/ZyNET.exe/P100IRF8.TXT?ZyActionD=ZyDocument&Client=EPA&Index=2011+Thru+2015&Docs=&Query=&Time=&EndTime=&SearchMethod=1&TocRestrict=n&Toc=&To cEntry=&QField=&QFieldYear=&QFieldMonth=&QFieldDay=&IntQFieldOp=0&ExtQFieldOp=0&XmlQuery=&File=D%3A%5Czyfiles%5CIndex%20Data%5C11thru15%5CTxt%5C00000010%5CP100I RF8.txt&User=ANONYMOUS&Password=anonymous&SortMethod=h%7C- &MaximumDocuments=1&FuzzyDegree=0&ImageQuality=r75g8/r75g8/x150y150g16/i425&Display=p%7Cf&DefSeekPage=x&SearchBack=ZyActionL&Back=ZyActionS&BackDesc=Results%20p age&MaximumPages=1&ZyEntry=1&SeekPage=x&ZyPURL Case # and Name: DCI Number: 1 Page: of

Footnotes:The following footnotes are referenced in column two (5. Study Title) of the Requirements Status and Registrant's Response form. These footnotes apply in addition to any test notes included in 40 CFR Part 158 with respect to the particular data requirement. Use Categories Key: A - Terrestrial food crop B - Terrestrial feed crop P - Aquatic nonfood crop R - Agricultural premises and equipment S - Food handling/storage establishments premises and equipment T - Commercial, institutional and industrial premises and equipment W - Human drinking water systems Y - Industrial processes and water systems - once through AA - Antifouling coatings Z - Industrial processes and water systems - not once through 2

### United States Environmental Protection Agency Washington, D.C. 20460 FOOTNOTES AND KEY DEFINITIONS FOR GUIDELINE REQUIREMENTS N/A - Bispyribac-sodium GDCI-078906-1470

4 5 6 7 8

9

10 11 12 13 14

15 Key:Residue of Concern = Residue of Concern; TEP = Typical End Use Product [TEP]; TGAI = Technical Grade Active Ingredient [TGAI]; TGAI/PAIRA = Technical Grade of the Active Ingredient or Pure Active Ingredient, Radio Labelled; TGAI, TEP = Technical Grade of the Active Ingredient or Technical End-Use Product; TGAI/PAI = Technical Grade Active Ingredient, Pure Active Ingredient

Three more soils are required to satisfy this guideline. This study must be done on two sediments. The need for a semi-field test for pollinators (i.e., either a field-feeding test or a tunnel test) will be determined based upon the results of lower tier tests and/or other lines of evidence, and the need for a refined pollinator risk assessment. The need for a field test for pollinators will be determined based upon lower-tiered tests and/or other lines of data and the need for a refined pollinator risk assessment. See information and guidance identified in the EPA documents, (i) USEPA. 2012. White Paper in Support of the Proposed Risk Assessment Process for Bees. Submitted to the FIFRA Scientific Advisory Panel for Review and Comment September 11 to 14, 2012. Office of Chemical Safety and Pollution Prevention Office of Pesticide Programs Environmental Fate and Effects Division, Environmental Protection Agency, Washington DC; Environmental Assessment Directorate, Pest Management Regulatory Agency, Health Canada, Ottawa, CN; California Department of Pesticide Regulation http://www.regulations.gov/#!documentDetail;D=EPA-HQ-OPP-2012-0543-0004; (ii) 2014 Guidance for Assessing Pesticide Risks to Bees. Office of Pesticide Programs United States Environmental Protection Agency, Health Canada Pest Management Regulatory Agency, California Department of Pesticide Regulation. June 19, 2014. http://www2.epa.gov/sites/production/files/2014-06/documents/pollinator_risk_assessment_guidance_06_19_14.pdf. OECD has not yet finalized test guidelines for chronic studies, and efforts are underway to develop standardized guidelines for assessing the effects from chronic exposure to adult and larvae in the laboratory. Discussion of the study design elements for the 10-day adult toxicity test can be found in Appendix O of the European Food Safety Authority (EFSA) guidance document: EFSA. Guidance on the risk assessment of plant protection products on bees (Apis mellifera, Bombus spp. and solitary bees. EFSA Journal 2013;11(7):3295, 266 pp. doi:10.2903/j.efsa.2013.3295. Available online at: http://www.efsa.europa.eu/en/efsajournal/doc/3295.pdf OECD has not yet finalized test guidelines for chronic studies with honey bee larvae. OECD draft guidance has is being developed, see OECD 2013b. OECD Draft Guidance Document Honey Bee (Apis mellifera) Larval Toxicity Test, Repeated Exposure. http://www.oecd.org/env/ehs/testing/Draft_GD_honeybees_rep_exp_for_2nd_CR_25_November_2013.pdf OECD 75 Guidance document on the Honey Bee (Apis mellifera L.) Brood Test under Semi-field conditions. Web: http://www.oecd.org/officialdocuments/ publicdisplaydocumentpdf/?cote=env/jm/mono(2007)22&doclanguage=en Measurements of residues in the pollen/nectar are needed based upon lower-tiered tests and/or other lines of evidence, and the need for a refined pollinator risk assessment. In some cases, information pertaining to acute toxicity to honey bee larvae may be obtained with the chronic honey bee larvae test thereby negating the need for separate acute and chronic larval toxicity tests. A study protocol must be submitted to, and reviewed by EPA, prior to study initiation. The following elements should be considered when developing study protocol(s) for the monitoring of residues in pollen/nectar. a. Consideration of the range of application methods and environmental conditions (e.g., soil and hydric regimes) that the target crop(s) may be under. b. Consideration of the attractiveness of the selected crop to pollinators c. Consideration of a collection schedule sufficient to allow for an understanding of the character of residues, in the pollen/nectar and/or plant tissues, over time. d. Consideration of data sufficient to determine whether residues of the active ingredient and/or degradation product(s) accumulates in soil and is/are bioavailable for plant to uptake in a following planting, and therefore result in potential exposure to pollinators. e. Consideration of the market proportion of the selected target crop(s). A study protocol must be submitted to, and reviewed by EPA, prior to study initiation. Case # and Name: DCI Number: 2 Page: of 2