----

| Date    | September, 2015                                                                                                                                                       |
|---------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------|
|    |                                                                                                                                                                  |
| Parties | Orgapharm S.A.S.of Rue du Moulin de la Canne, Pithiviers France 45 300(Orgapharm)                                                                                |
|    |                                                                                                                                                                  |
|    | Prana Biotechnology Ltd ACN 080 699 065of Level  2, 369 Royal Parade, Parkville Victoria Australia 3052(Prana) (each a party and collectively, the parties) |

----

| A | Prana is in the business of developing drug candidates for the treatment of neurodegenerative diseases. |
|---|---------------------------------------------------------------------------------------------------------|

| B | Orgapharm is in the business of manufacturing fine chemicals. |
|---|---------------------------------------------------------------|

| C | Prana has sought the assistance of Orgapharm to manufacture PBT2 API. There may also be occasions in future where Prana may call on Orgapharm to provide other pharmaceutical manufacturing and related services. |
|---|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| D | This Agreement contains the terms and conditions upon which Orgapharm will provide services to Prana. |
|---|-------------------------------------------------------------------------------------------------------|

----

| 1 | Definitions and Interpretation |
|---|--------------------------------|

| 1.1 | In this Agreement: |
|-----|--------------------|

|  | (a) | the Deliverables; and |
|--|-----|-----------------------|

|  | (b) | the Results, |
|--|-----|--------------|

----

|  | (b) | Prana’s input in pursuance of this Agreement to facilitate the performance of the Services by Orgapharm; and |
|--|-----|--------------------------------------------------------------------------------------------------------------------|

|  | (c) | the use of the Agreement IP by Prana for its business purposes. |
|--|-----|-----------------------------------------------------------------|

|  | (a) | a material breach by Orgapharm of its obligations under this Agreement or the Quality Agreement; |
|--|-----|--------------------------------------------------------------------------------------------------|

|  | (b) | receipt by Orgapharm of an FDA Form 483 or Warning Letter or other like document from the EMA or any other regulatory authority; |
|--|-----|----------------------------------------------------------------------------------------------------------------------------------|

|  | (c) | any audit, inspection or product, documentation or information request by the FDA, TGA or other regulatory authority which is specific to Prana’s Compounds. |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (a) | the principles and guidelines of good manufacturing practice stated in Commission Directive 2003/94/EC; and |
|--|-----|-------------------------------------------------------------------------------------------------------------|

|  | (b) | the guidelines published by the European Commission in EudraLex Volume 4, |
|--|-----|---------------------------------------------------------------------------|

----

|  | (a) | prior to the Commencement Date; or |
|--|-----|------------------------------------|

|  | (b) | independent of this Agreement and without the use of the other party’s Confidential Information, |
|--|-----|--------------------------------------------------------------------------------------------------------|

|  | (a) | an application is made to a court for an order that a party be wound-up or that a provisional liquidator be appointed (unless the application is withdrawn, struck out or dismissed within 45 days of it being made); |
|--|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (b) | a liquidator is appointed in respect of a party; |
|--|-----|--------------------------------------------------|

|  | (c) | an administrator, receiver or receiver and manager is appointed in relation to a party or in respect of any of its assets; |
|--|-----|----------------------------------------------------------------------------------------------------------------------------|

|  | (d) | except to reconstruct or amalgamate while solvent on terms approved by the other party, a party enters into, or resolves to enter into, an arrangement or composition with, or assignment for the benefit of, all or any of its creditors, or it, or anyone on its behalf, proposes a reorganisation, moratorium, deed of company arrangement or other administration involving any of them or the winding up or dissolution of the party; |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (e) | a party is, states that it is or is presumed under any applicable law to be, insolvent; and |
|--|-----|---------------------------------------------------------------------------------------------|

|  | (f) | anything having a substantially similar effect to any of the events specified above happens under the law of any jurisdiction. |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------|

----

|  | (a) | Proposals; and |
|--|-----|----------------|

|  | (b) | all: |
|--|-----|------|

|  | (i) | Existing IP of Orgapharm; |
|--|-----|---------------------------|

|  | (ii) | information concerning Orgapharm’s affairs, assets or property or any business, property or transaction in which it may be or may have been concerned or interested; |
|--|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (iii) | information which, by its nature or by the circumstances of its disclosure, is or could reasonably be expected to be regarded as confidential to Orgapharm, |
|--|-------|-------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (a) | the Compounds; |
|--|-----|----------------|

|  | (b) | RFPs; |
|--|-----|-------|

|  | (c) | Agreement IP; and |
|--|-----|-------------------|

|  | (d) | all: |
|--|-----|------|

|  | (i) | Existing IP of Prana; |
|--|-----|-----------------------|

|  | (ii) | data, results, information, analyses, papers, materials, records, notes, documents and reports concerning: |
|--|------|------------------------------------------------------------------------------------------------------------|

|  | (A) | the Compounds; |
|--|-----|----------------|

|  | (B) | the synthesis or commercial manufacture of the Compounds; |
|--|-----|-----------------------------------------------------------|

|  | (C) | research, tests, trials and studies planned or conducted in relation to the Compounds; |
|--|-----|----------------------------------------------------------------------------------------|

|  | (D) | Prana’s dealings with regulatory authorities around the world in relation to any Compound; |
|--|-----|--------------------------------------------------------------------------------------------------|

|  | (ii) | information concerning Prana’s affairs, assets or property or any business, property or transaction in which it may be or may have been concerned or interested; |
|--|------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (iii) | information which, by its nature or by the circumstances of its disclosure, is or could reasonably be expected to be regarded as confidential to Prana, |
|--|-------|---------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|  | (b) | any subsequent project for the delivery of agreed Services by Orgapharm to Prana under this Agreement. |
|--|-----|--------------------------------------------------------------------------------------------------------|

|  | (a) | information which, at the time of disclosure, was published, known publicly or otherwise in the public domain; |
|--|-----|----------------------------------------------------------------------------------------------------------------|

|  | (b) | information which, after disclosure, is published, becomes known publicly, or otherwise becomes part of the public domain through no fault of the receiving party; |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (c) | information which, prior to the time of disclosure, is known to the receiving party as evidenced by its written records or other tangible evidence; |
|--|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (d) | information which is made available to the receiving party in good faith by a third party who is under no obligation of confidence to the disclosing party; |
|--|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (e) | information which the receiving party is required to disclose by law, provided the receiving party has given the disclosing party prompt prior notice and assistance in any reasonable effort to obtain confidential treatment with respect to such disclosure; or |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (f) | information which is independently developed by or for the receiving party without use of, reliance upon, or with reference to the disclosing party’s Confidential Information. |
|--|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (a) | all results, data, information, processes, procedures, methodologies, techniques, concepts, ideas, compounds, formulations, materials, reports, analyses, documents, items or things; and |
|--|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (b) | all discoveries, inventions, developments, modifications, innovations, enhancements or improvements, |
|--|-----|------------------------------------------------------------------------------------------------------|

|  | (a) | annexed to a Work Order or incorporated therein by reference; or |
|--|-----|------------------------------------------------------------------|

----

|  | (b) | prepared and agreed by the parties during the course of a Project. |
|--|-----|--------------------------------------------------------------------|

|  | (a) | proprietary compounds, samples, prototypes, formulations, ideas, knowledge, concepts, methods, techniques, processes, procedures, trade secrets, technology, discoveries, inventions, know-how, data, technical and scientific information, research and development results, development plans, test results, procedures for experiments and tests and manufacturing scale-ups, methods or schemes for synthesising chemicals and compounds, isolation and purification methods, hardware and software; |
|--|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (b) | patents, patentable inventions, designs, trade marks, works of copyright and rights in confidential information; |
|--|-----|------------------------------------------------------------------------------------------------------------------|

|  | (c) | all other intellectual property of any kind, whether or not protectable under patent, trade mark, copyright, design or other intellectual property laws. |
|--|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------|

| 1.2 | In this Agreement, unless the context requires another meaning: |
|-----|-----------------------------------------------------------------|

|  | (a) | a reference to: |
|--|-----|-----------------|

|  | (ii) | a document (including this Agreement) is a reference to that document (including any Schedules and Annexures) as amended, consolidated, supplemented, novated or replaced; |
|--|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (iii) | an item, Recital, clause, Schedule or Annexure is to an item, Recital, clause, Schedule or Annexure of or to this Agreement; |
|--|-------|------------------------------------------------------------------------------------------------------------------------------|

|  | (iv) | a notice means a notice, approval, demand, request, nomination or other communication given by one party to another under or in connection with this Agreement; |
|--|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (v) | a person (including a party) includes an individual, company, other body corporate, association, partnership, firm, joint venture, trust or government agency; and |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (vi) | the words "including" or "includes" means "including, but not limited to", or "includes, without limitation" respectively; |
|--|------|----------------------------------------------------------------------------------------------------------------------------|

|  | (b) | where a word or phrase is defined, its other grammatical forms have a corresponding meaning; and |
|--|-----|--------------------------------------------------------------------------------------------------|

----

|  | (c) | headings are for convenience only and do not affect interpretation of this Agreement. |
|--|-----|---------------------------------------------------------------------------------------|

| 1.3 | This Agreement may not be construed adversely to a party only because that party was responsible for preparing it. |
|-----|--------------------------------------------------------------------------------------------------------------------|

----

| 2 | Term |
|---|------|

| 2.1 | This Agreement commences on the Commencement Date and continues for five (5) years or until the completion of any then current Work Order by Orgapharm, unless terminated earlier in accordance with this Agreement. This Agreement may be extended by mutual agreement of the parties in writing. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3 | Services and Work Orders |
|---|--------------------------|

| 3.1 | If at any time during the Term Prana wishes to engage Orgapharm to provide Services to it, then subject to the parties entering a Work Order in respect of the Services, Orgapharm  agrees to provide the Services on the terms and conditions contained in this Agreement. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.2 | Each Work Order: |
|-----|------------------|

|  | (a) | is incorporated herein by reference; |
|--|-----|--------------------------------------|

|  | (b) | shall be in a form similar to the sample Work Order attached to this Agreement as Annexure A; |
|--|-----|-----------------------------------------------------------------------------------------------|

|  | (c) | shall include a description of the specific services to be performed by Orgapharm, the deliverables, timelines, protocols, specifications, fees and charges payable by Prana and such other details and terms as are agreed to by the parties; |
|--|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (d) | is taken to include the Quality Agreement and all applicable Specifications. |
|--|-----|------------------------------------------------------------------------------|

| 3.3 | In the event of any conflict between the terms and conditions of a Work Order and a provision of this Agreement, the terms and conditions of this Agreement shall prevail unless the Work Order expressly specifies that the particular term of the Work Order takes precedence. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 3.4 | Any change to a Work Order must be mutually agreed and documented by Orgapharm in a written amendment to the Work Order (a “Change Order”). When a signed Change Order is received from Prana, the Change Order shall constitute an amendment to the applicable Work Order and shall be considered part of this Agreement.  No changes to a Work Order will take effect and Orgapharm must not commence any new or changed Services unless and until it has received a signed Change Order from Prana. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 4 | Orgapharm’s Obligations and Warranties |
|---|----------------------------------------------|

| 4.1 | Orgapharm will perform each Project and the associated Services: |
|-----|------------------------------------------------------------------|

|  | (a) | using suitably qualified Representatives; |
|--|-----|-------------------------------------------|

|  | (b) | in a timely manner in accordance with the Work Order; |
|--|-----|-------------------------------------------------------|

|  | (c) | with due care and skill and to the best of Orgapharm’s knowledge and expertise; |
|--|-----|---------------------------------------------------------------------------------------|

|  | (d) | in accordance with relevant local industry standards, best practice and guidelines or where none apply, relevant international industry standards, best practice and guidelines; |
|--|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (e) | in accordance with cGMP, the Work Order and all applicable Laws; |
|--|-----|------------------------------------------------------------------|

----

|  | (f) | in accordance with any reasonable direction given by Prana; and |
|--|-----|-----------------------------------------------------------------|

|  | (g) | otherwise in accordance with the provisions of this Agreement. |
|--|-----|----------------------------------------------------------------|

| 4.2 | Orgapharm represents and warrants that: |
|-----|-----------------------------------------|

|  | (a) | it has the right to enter into this Agreement; |
|--|-----|------------------------------------------------|

|  | (b) | it has and will maintain the requisite licences from the EMA, FDA, TGA and all other applicable governmental, municipal and public agencies, bodies and authorities for the conduct of its business at each of its premises; |
|--|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (c) | it has and will maintain all rights, title, licences, interests, property, equipment and resources necessary to fully and lawfully perform each Project and the associated Services; |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (d) | it and its Representatives  have the necessary experience, skill, knowledge and competence to perform each Project and the associated Services; |
|--|-----|------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (e) | each Deliverable will meet the Specification and be: |
|--|-----|------------------------------------------------------|

|  | (i) | complete, accurate, free from errors and fit for the purpose/s for which it is required by Prana; |
|--|-----|---------------------------------------------------------------------------------------------------|

|  | (ii) | compliant with all requirements specified in this Agreement and the relevant Work Order; |
|--|------|------------------------------------------------------------------------------------------|

|  | (iii) | cGMP compliant and otherwise compliant with all other applicable Laws; |
|--|-------|------------------------------------------------------------------------|

|  | (iv) | provided at the time and in the manner and form prescribed in the relevant Work Order. |
|--|------|----------------------------------------------------------------------------------------|

| 4.3 | Orgapharm will: |
|-----|-----------------|

|  | (a) | permit all relevant inspections by the EMA, FDA, TGA or other regulatory authorities of its premises, procedures and documentation; |
|--|-----|-------------------------------------------------------------------------------------------------------------------------------------|

|  | (b) | notify Prana: |
|--|-----|---------------|

|  | (i) | within five (5) Business Days of receiving any notice of inspection from the EMA, FDA, TGA or other regulatory authority; |
|--|-----|---------------------------------------------------------------------------------------------------------------------------|

|  | (ii) | within three (3) Business Days of receiving any request from the EMA, FDA, TGA or other regulatory authority for Prana’s Compounds, products or samples or related batch or other documentation or information; |
|--|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (iii) | within one (1) Business Day of receiving any FDA Form 483 or Warning Letter or other like document from the EMA, TGA or any other regulatory authority which relates to Prana’s Compounds or which may impact on Orgapharm’s ability to supply such products (in accordance with a Work Order) or the facilities used to produce, test or package them, |
|--|-------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 4.4 | Orgapharm must: |
|-----|-----------------|

|  | (a) | take out and maintain during the term of this Agreement and for 12 months thereafter, appropriate public and product liability insurance policies with a reputable insurer which give coverage against all usual risks and for an amount of at least $ €10,000,000 per occurrence. |
|--|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (b) | at Prana’s request provide Prana with certificates of currency for those policies. |
|--|-----|------------------------------------------------------------------------------------------|

----

| 5 | Project Obligations |
|---|---------------------|

| 5.1 | For each Project: |
|-----|-------------------|

|  | (a) | Orgapharm will designate a project leader to liaise with Prana in relation to Orgapharm’s performance of the Services and the provision of the Deliverables (the “Project Leader”); and |
|--|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (b) | Prana will designate a contact who will be the point of contact for the Project Leader (the “Prana Contact”). |
|--|-----|---------------------------------------------------------------------------------------------------------------------------|

| 5.2 | The parties must agree the Specifications for each Deliverable and Orgapharm must receive written authority from the Prana Contact or Prana’s Chief Operating Officer before commencing any Sub-Project.  Without such agreement and authority for a given Sub-Project, Orgapharm must not undertake and may not charge Prana its fee for the Sub-Project or any other amount. If in relation to a given Sub-Project, Prana provides written authority to undertake the Sub-Project after the relevant commencement date specified in the Work Order, then Orgapharm shall commence the Sub-Project as soon as is reasonably practicable thereafter, and in any event, not later than 14 days after Prana provides written authority to undertake the Sub-Project. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5.3 | Orgapharm must provide the following updates and reports to the Prana Contact for each Project: |
|-----|-------------------------------------------------------------------------------------------------|

|  | (a) | prompt email notification of any material technical or operational problems or issues encountered by Orgapharm; |
|--|-----|-----------------------------------------------------------------------------------------------------------------|

|  | (b) | fortnightly written updates (in a format acceptable to Prana) of the work undertaken and the Results obtained for the fortnight, problems encountered by Orgapharm, the stage of each Project or Sub-Project, as applicable that Orgapharm is up to and any other information that would be relevant to Prana in relation to the Project; and |
|--|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (c) | such reports specified in the applicable Work Order for the Project. |
|--|-----|----------------------------------------------------------------------|

| 5.4 | Orgapharm must create a separate project folder in the applicable department directory in its computer system: |
|-----|----------------------------------------------------------------------------------------------------------------|

|  | (a) | which is dedicated to Prana Projects; and |
|--|-----|-------------------------------------------|

|  | (b) | accessible only by those Orgapharm Representatives working on such projects. |
|--|-----|------------------------------------------------------------------------------|

| 5.5 | Copies of all letters, reports, memos, notes, documents and other written materials created or brought into existence by Orgapharm in relation to each Project shall be saved electronically and stored by Orgapharm on the Prana drive. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5.6 | All Results arising out of the Project must be recorded in a written format.  The results captured in a written format must: |
|-----|-----------------------------------------------------------------------------------------------------------------------------------|

|  | (a) | be maintained and signed in accordance with best industry practice; and |
|--|-----|-------------------------------------------------------------------------|

|  | (b) | be made available for inspection by Prana upon request by Prana in writing. |
|--|-----|-----------------------------------------------------------------------------|

| 5.7 | If they have not already done so, the parties agree to put a quality agreement in place for the purpose of the Services to be undertaken by Orgapharm under this Agreement. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5.8 | On 30 days prior written notice, Orgapharm (or such shorter period of notice as may be agreed in good faith by the parties) must allow Prana to undertake an audit of its premises, procedures actions and documentation in relation to Prana’s Projects, Compounds and Agreement IP and Orgapharm’s observance of obligations under this Agreement and the Quality Agreement. Prana audits shall be limited to one audit with a maximum of two (2) auditors for two (2) days (or otherwise as may be negotiated in advance and agreed  by the parties) per calendar year except if Prana reasonably believes that  a Cause Event has occurred, in which case Prana may conduct an additional audit with  48 hrs  prior written notice. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 5.9 | At any time during the conduct of a Project on prior notice by Prana, Orgapharm must allow Prana or any Representative of it to attend any premises at which a Project is being conducted for the purpose of assessing the progress of the Project. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5.10 | If at any time during or after the termination of this Agreement, Prana requires a third party to perform any work relating to a Compound, including its manufacture, then Orgapharm must, at the request of Prana, co-operate with Prana and the third party and provide such assistance, advice, documentation and information (including the relevant Results) as is necessary to enable the third party to perform the work requested by Prana. Prana agrees to pay all out-of-pocket expenses reasonably incurred by Orgapharm, provided that any anticipated expenses in excess of USD$1,000 are approved by Prana in writing before they are incurred. |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 5.11 | It is agreed in relation to any Deliverables supplied by Orgapharm pursuant to this Agreement that Prana shall have fifteen (15) days (“Testing Period”) from the date they are delivered to perform acceptance testing on the Deliverables in order to confirm that they comply with the Specifications  (“Acceptance Testing”). If Prana is satisfied that the Deliverables meet Specification, then it will confirm this in writing to Orgapharm and pay the applicable payment.  If Prana finds that any Deliverables supplied by Orgapharm do not meet specification, then Prana will immediately notify Orgapharm in writing of any non-compliance.  If the non-compliance relates to: |
|------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (a) | Product supplied to Prana, then Prana may by written notice: |
|--|-----|--------------------------------------------------------------|

|  | (i) | require that Orgapharm (at Orgapharm’s cost) manufacture and supply the applicable quantity of Product again based on: |
|--|-----|------------------------------------------------------------------------------------------------------------------------------|

|  | (A) | a manufacture start  as soon as practicable after the date of Prana’s notice, and as agreed in good faith by both parties, given the understanding that delay in delivery of  acceptable Product will adversely impact Prana; |
|--|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (B) | a manufacturing period less than or equal to the period of time originally allocated for the activity in the Work Order; or |
|--|-----|-----------------------------------------------------------------------------------------------------------------------------|

|  | (ii) | terminate the Project in whole or in part, in which case Prana will not be liable to pay for, and Orgapharm must immediately refund any moneys paid by Prana (if any) on account of, the Project or the terminated part of it; |
|--|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (b) | services or documents or Results supplied, then Prana may by written notice: |
|--|-----|------------------------------------------------------------------------------|

|  | (i) | require that Orgapharm (at Orgapharm’s cost) immediately repeat the services or re-write the documents to rectify the non-compliance as soon as practicable thereafter;; or |
|--|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (ii) | terminate the Project in whole or in part, in which case Prana will not be liable to pay for, and Orgapharm must immediately refund any moneys paid by Prana (if any) on account of, the Project or the terminated part of it. |
|--|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 6 | Fees and Charges |
|---|------------------|

| 6.1 | Orgapharm shall invoice Prana in a manner consistent with the payment schedule and other terms and conditions set out in the relevant Work Order.  Payment of invoices shall be due thirty (30) days after the date of each invoice unless any milestone or Deliverable or Service referable to the invoiced Services has not been satisfied or supplied in accordance with the Work Order or this Agreement in which case payment shall be due on the later of thirty (30) days after the date of the invoice or the date when the milestone is satisfied or the Deliverable or Service is supplied in accordance with the Work Order or this Agreement. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 7 | Risk and Property |
|---|-------------------|

| 7.1 | Property in any Product produced by Orgapharm pursuant to a Work Order will pass to Prana upon payment for it in full. Risk in the Product will remain with Orgapharm while in storage at Orgapharm’s premises but will otherwise pass to Prana on despatch from its premises to Prana or Prana’s nominee. |
|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 8 | Intellectual Property |
|---|-----------------------|

| 8.1 | The parties acknowledge and agree that all Agreement IP will vest in and be solely owned by Prana. Orgapharm hereby assigns all of Orgapharm’s right, title and interest (if any) in the Agreement IP to Prana with effect from the time it is generated or comes into existence. |
|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 8.2 | Orgapharm and its Representatives must give Prana all assistance and advice and execute all documents as may be required by Prana from time to time in relation to: |
|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (a) | any assignment that may be required to transfer Agreement IP to Prana; |
|--|-----|------------------------------------------------------------------------|

|  | (b) | any applications by Prana for patents or other registrable Intellectual Property Rights in respect of the Agreement IP; |
|--|-----|-------------------------------------------------------------------------------------------------------------------------|

|  | (c) | any applications, submissions or other documents that Prana seeks to file with a regulatory authority or other government department, agency or body to obtain an approval or consent in relation to its proprietary compounds; |
|--|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (d) | any other purpose reasonably arising from or incidental to this Agreement. |
|--|-----|----------------------------------------------------------------------------|

| 8.3 | This Agreement will not affect the ownership of a party’s Existing IP which is, and will continue to be, solely owned by that party. In particular, it is expressly agreed Orgapharm will remain the sole owner of any and all of its Existing IP (including its Existing IP used in connection with any given Project or Work Order). |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 8.4 | Orgapharm grants Prana a non-exclusive, perpetual, worldwide, royalty-free licence (with the right to grant sublicences) to use and reproduce its Existing IP to the extent necessary to enable Prana to use the Agreement IP for the sole purpose of manufacturing and marketing PBT2 or any other PBT2 pharmacophore Compound. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 9 | Confidentiality |
|---|-----------------|

| 9.1 | Each party: |
|-----|-------------|

|  | (a) | acknowledges and agrees that the Confidential Information of the other party will at all times remain the exclusive property of that other party; and |
|--|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (b) | undertakes to keep the Confidential Information of the other party secret and to protect and preserve the confidential nature and secrecy of that Confidential Information. |
|--|-----|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.2 | Prana agrees and acknowledges in relation to Orgapharm Confidential Information, and Orgapharm agrees and acknowledges in relation to Prana Confidential Information, that it: |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (a) | may only use or reproduce the other party’s Confidential Information for the Approved Purposes; |
|--|-----|-------------------------------------------------------------------------------------------------------|

|  | (b) | must not disclose the other party’s Confidential Information to any person except as permitted by this Agreement; |
|--|-----|-------------------------------------------------------------------------------------------------------------------------|

----

|  | (c) | must not permit unauthorised persons to have access to the other party’s Confidential Information; |
|--|-----|----------------------------------------------------------------------------------------------------------|

|  | (d) | must not make, or assist or permit any person (including its Representatives) to make any unauthorised use, disclosure or reproduction of the other Party’s Confidential Information; |
|--|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (e) | must ensure that any person who has access to the other party’s Confidential Information does not make any unauthorised use, reproduction or disclosure of that information; |
|--|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (f) | must enforce the confidentiality obligations imposed or required to be imposed by this Agreement, including diligently prosecuting at its cost any breach or threatened breach of those confidentiality obligations by a person to whom that party has disclosed the other Party’s Confidential Information and, where appropriate, making applications for interim or interlocutory relief; and |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (g) | must provide assistance reasonably requested by the other party, in relation to any proceedings the other party may take against any person for unauthorised use, copying or disclosure of the other Party’s Confidential Information. |
|--|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.3 | A party may disclose the other party’s Confidential Information to a Representative on a need to know basis but in each case, only to the extent necessary for the Approved Purposes, and provided the Representative is placed under confidentiality obligations no less onerous than those set out in this Agreement. |
|-----|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.4 | Each party must: |
|-----|------------------|

|  | (a) | establish and maintain effective security measures to safeguard the other party’s Confidential Information from access or use not authorised under this Agreement; |
|--|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (b) | keep the other party’s Confidential Information under its own control; |
|--|-----|------------------------------------------------------------------------------|

|  | (c) | immediately notify the other party of any suspected or actual unauthorised use, copying or disclosure of the other party’s Confidential Information; |
|--|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.5 | Either party may at any time by notice in writing to the other party request the return, deletion or destruction of all Material Forms of its Confidential Information in the possession, power or control of the other party or any of its Representatives (whether or not those Material Forms were created by the other party or its Representatives) and the other party must immediately comply with such request.  In the case of Prana Compounds to be returned by Orgapharm, the parties acknowledge and agree that Orgapharm may retain samples of any Compounds manufactured by it so that it may comply with its cGMP obligations. |
|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.6 | The return, deletion or destruction, as applicable, of the Material Forms of Confidential Information under clause 9.5 does not release a Party from its obligations under this clause 10. |
|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 9.7 | Each party acknowledges and agrees that: |
|-----|------------------------------------------|

|  | (a) | its breach of this Agreement would be harmful to the business interests of the other party; |
|--|-----|---------------------------------------------------------------------------------------------|

|  | (b) | monetary damages alone would not be a sufficient remedy for a breach of this Agreement; and |
|--|-----|---------------------------------------------------------------------------------------------|

|  | (c) | in addition to any other remedy which may be available in law or equity, a party is entitled to interim, interlocutory and permanent injunctions or any of them, to prevent breach of this Agreement and to compel specific performance of it. |
|--|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 10 | **Liability** |
|----|---------------|

| 10.1 | Except as expressly provided to the contrary in this Agreement, all terms, conditions, warranties, guarantees, undertakings or representations of any kind made by or on behalf of a party, prescribed by statute or implied in relation to the subject matter of this Agreement are, to the fullest extent permitted by law, excluded. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.2 | Subject to clause 10.4 and except to the extent that liability may not be lawfully excluded, Orgapharm’s liability in respect of all and any claims arising under this Agreement in relation to a Work Order, including any breach of this Agreement by Orgapharm or any negligence of Orgapharm or its Representatives, cannot exceed three times the agreed aggregate contract price for all works specified in the Work Order. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.3 | Notwithstanding any other provision of this Agreement, neither party shall have any liability to the other for any consequential loss suffered or incurred by the other party, however arising. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 10.4 | Clauses 10.2 and 10.3 shall have no application to any claim arising from a breach by either party of clause 9. |
|------|-----------------------------------------------------------------------------------------------------------------|

| 10.5 | Prana shall indemnify and hold harmless Orgapharm in respect of any and all claims or demands by any third party against Orgapharm alleging loss, damage, personal injury or death arising out of the Deliverables provided by Orgapharm save and except for claims for loss, damage, injury or death arising directly or indirectly from any negligence or recklessness on the part of Orgapharm or any intentionally harmful act or omission by Orgapharm or any Representative of it  or any infringement by Orgapharm of the third party’s intellectual property rights. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 11 | Termination |
|----|-------------|

| 11.1 | Either party may terminate this Agreement and/or any Work Order by written notice to the other party with immediate effect from the date of the notice or any later date that it may nominate if: |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (a) | the other party materially breaches this Agreement and fails to remedy such breach within 30 days of receipt of notice from the first party specifying the breach and requiring it to be remedied; |
|--|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (b) | the other party materially breaches this Agreement and the breach is incapable of remedy; or |
|--|-----|----------------------------------------------------------------------------------------------|

|  | (c) | an Insolvency Event happens to the other party. |
|--|-----|-------------------------------------------------|

| 11.2 | Prana may terminate this Agreement and/or or any Work Order (or any part of a Work Order) by giving Orgapharm 30 days written notice. For any incomplete Work Order, Orgapharm must, unless otherwise directed by Prana, cease work immediately and use its commercially reasonable efforts to mitigate any reimbursable expenses or non-cancellable commitments properly incurred in accordance with this Agreement or the applicable Work Order. |
|------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 11.3 | Upon the termination of this Agreement or any Work Order pursuant to clauses 11.1, 11.2 or 11.2, Orgapharm may invoice Prana for Services and reimbursable expenses and non-cancellable commitments properly performed or incurred in accordance with this Agreement and the applicable Work Order through to the date of termination (Final Invoice). In the absence of any offsetting claim, Prana agrees to immediately pay all outstanding invoices and otherwise pay the Final Invoice (or so much thereof as may be due having regard to any up-front fees already paid) within 30 days of the date of the invoice. If after raising the Final Invoice, Prana’s account is in credit, then Orgapharm shall immediately refund the credit balance. |
|------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 11.4 | The expiry or termination of this Agreement will not affect or limit any accrued rights of the parties. |
|------|---------------------------------------------------------------------------------------------------------|

| 11.5 | Clauses 1, 4.2, 4.4, 5.10, 7, 8, 9, 10, 11, 14.15 and 14.16 shall survive the termination of this Agreement. |
|------|--------------------------------------------------------------------------------------------------------------|

----

| 12 | Force Majeure |
|----|---------------|

| 12.1 | If any party to this Agreement is unable to carry out any obligation (other than to pay money), by reason of Force Majeure, then that obligation will be suspended so far as it is affected by the Force Majeure for the duration of the Force Majeure.  The party affected must promptly give written notice to the other party of the Force Majeure with full particulars thereof and so far as is known, the probable extent to which that party will be unable to perform or will be delayed in performing the obligation. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 12.2 | If: |
|------|-----|

|  | (a) | performance of an obligation is prevented by Force Majeure; or |
|--|-----|----------------------------------------------------------------|

|  | (b) | a delay caused by Force Majeure exceeds 90 days, |
|--|-----|-------------------------------------------------------|

----

| 13 | Notices |
|----|---------|

| 13.1 | All notices must be: |
|------|----------------------|

|  | (a) | in legible writing and in English; |
|--|-----|------------------------------------|

|  | (b) | addressed to the recipient at the address or facsimile number set out below or to any other address or facsimile number that a party may notify to the other: |
|--|-----|---------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | Address:                                                                  | Rue du Moulin de la Canne,Pithiviers France 45 300 |
|--------|---------------------------------------------------------------------------|---------------------------------------------------------|
|   |  Attention:                                                          |  Rabiaâ Berkous                               |
|   | Facsimile no:                                                             | 33(0)2 38 30 24 2 4                                     |
|   |                                                                      |                                                    |
|   | to Prana:                                                                 |                                                    |
|   |                                                                      |                                                    |
|   | Address:                                                        | Level 2, 369 Royal Parade                               |
|   |                                                                      | Parkville Victoria 3052                                 |
|   |                                                                      | Australia                                               |
|   |                                                                      |                                                    |
|   | Attention:                                                                | Dianne Angus                                            |
|   |                                                                      |                                                    |
|   | Facsimile no:           | 9348 0377                                               |

|  | (c) | signed by the party or, where the sender is a company, by an authorised representative of the sender; and |
|--|-----|-----------------------------------------------------------------------------------------------------------|

----

|  | (d) | sent to the recipient by hand, prepaid post or facsimile. |
|--|-----|-----------------------------------------------------------|

| 13.2 | Without limiting any other means by which a party may be able to prove that a notice has been received by the other party, a notice will be considered to have been received: |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (a) | if sent by hand, when left at the address of the recipient; |
|--|-----|-------------------------------------------------------------|

|  | (b) | if sent by prepaid post, 2 days after the date of posting; or |
|--|-----|---------------------------------------------------------------|

|  | (c) | if sent by facsimile, on receipt by the sender of an acknowledgment or transmission report generated by the sender's machine indicating that the whole facsimile was sent to the recipient's facsimile number; |
|--|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

| 14 | General provisions |
|----|--------------------|

| 14.1 | This Agreement and any other documents referred to in this Agreement or executed in connection with this Agreement is the entire agreement of the parties about the subject matter of this Agreement and supersedes all other representations, negotiations, arrangements, understandings or agreements and all other communications.  No party has entered into this Agreement relying on any representations made by or on behalf of the other, other than those expressly made in this Agreement. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 14.2 | Each party must, at its own expense, whenever reasonably requested by the other party, promptly do or arrange for others to do, everything reasonably necessary or desirable to give full effect to this Agreement and the transactions contemplated by this Agreement. |
|------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 14.3 | Each party must pay its own costs in respect of this Agreement and the documents and transactions contemplated by this Agreement. |
|------|-----------------------------------------------------------------------------------------------------------------------------------|

| 14.4 | Orgapharm must not subcontract the Services or assign or otherwise transfer, create any charge, trust or other interest in, or otherwise deal in any other way with any of its rights under this Agreement without the prior written consent of Prana.  Orgapharm shall remain responsible for any Services performed by any subcontractors to the same extent as if such Services were being performed by Orgapharm itself. |
|------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 14.5 | If a provision of this Agreement is invalid or unenforceable in a jurisdiction: |
|------|---------------------------------------------------------------------------------|

|  | (a) | it is to be read down or severed to the extent of the invalidity or unenforceability; and |
|--|-----|-------------------------------------------------------------------------------------------|

|  | (b) | that fact does not affect the validity or enforceability of the remaining provisions. |
|--|-----|---------------------------------------------------------------------------------------|

| 14.6 | A waiver by a party of a provision of or of a right under this Agreement is binding on the party granting the waiver only if it is given in writing and is signed by the party or an authorised representative of the party granting the waiver. |
|------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 14.7 | A waiver is effective only in the specific instance and for the specific purpose for which it is given. |
|------|---------------------------------------------------------------------------------------------------------|

----

| 14.8 | A single or partial exercise of a right by a party does not preclude another exercise of that right or the exercise of another right. |
|------|---------------------------------------------------------------------------------------------------------------------------------------|

| 14.9 | Failure by a party to exercise or delay in exercising a right does not prevent its exercise or operate as a waiver. |
|------|---------------------------------------------------------------------------------------------------------------------|

| 14.10 | This Agreement may be amended only by a document signed by all parties. |
|-------|-------------------------------------------------------------------------|

| 14.11 | This Agreement may be signed in counterparts, both of which shall be deemed to be an original but when taken together shall constitute one and the same agreement and shall become effective when a counterpart has been signed by each of the parties hereto and delivered to the other (by facsimile, pdf or otherwise). |
|-------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 14.12 | The rights, remedies and powers of the parties under this Agreement are cumulative and do not exclude any other rights, remedies or powers. |
|-------|---------------------------------------------------------------------------------------------------------------------------------------------|

| 14.13 | A party may give its approval or consent conditionally or unconditionally or withhold its approval or consent in its absolute discretion unless this Agreement expressly provides otherwise. |
|-------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 14.14 | This Agreement is binding on, and has effect for the benefit of, the parties and their respective successors and permitted assigns. |
|-------|-------------------------------------------------------------------------------------------------------------------------------------|

| 14.15 | This Agreement is governed by the laws of Victoria, Australia. |
|-------|----------------------------------------------------------------|

| 14.16 | Each party irrevocably and unconditionally: |
|-------|---------------------------------------------|

|  | (a) | submits to the non-exclusive jurisdiction of the courts of Victoria in relation to any dispute or claim arising out of or in connection with the subject matter of this agreement; |
|--|-----|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|  | (b) | waives, without limitation, any claim or objection based on absence of jurisdiction or inconvenient forum. |
|--|-----|------------------------------------------------------------------------------------------------------------|

----

| Signed for and on behalf of             |   |   |
|-----------------------------------------|--------|--------|
| Orgapharm S.A.S.                        |   |   |
| by its authorised  representative: |   |   |
|                                    |   |   |
|                                    |   |   |
| Signature of authorised representative  |   |   |
|                                    |   |   |
|                                    |   |   |
| Name (please print)                     |   |   |
| Title (please print)                                                         |   |   |
|------------------------------------------------------------------------------|--------|--------|
|  Signed for and on behalf ofPrana Biotechnology LtdACN 080 699 065 |   |   |
| by its authorised representative:                                            |   |   |
|                                                                    |   |   |
| Signature of authorised representative                                       |   |   |
|                                                                         |   |   |
|                                                                         |   |   |
| Name (please print)                                                          |   |   |
|                                                                    |   |   |
| Title (please print)                                                         |   |   |

----

----

| 1. | Background |
|----|------------|

| 2. | Description of Services and Deliverables |
|----|------------------------------------------|

| 3. | Responsibilities |
|----|------------------|

| 4. | Project Timeline |
|----|------------------|

| 5. | Fees, Reimbursable Expenses and Payment Schedule |
|----|--------------------------------------------------|

| 6. | Any other applicable terms and conditions not covered in the MSA |
|----|------------------------------------------------------------------|

| 7. | Exhibits to the Work Order (e.g. specifications, Quality Agreement) |
|----|---------------------------------------------------------------------|

| Orgapharm S.A.S | Prana Biotechnology Ltd |   |
|-----------------|-------------------------|--------|
|            |                    |   |
| By:             | By:                     |   |
|            |                    |   |
| Name:           | Name:                   |   |
|            |                    |   |
| Title:          | Title:                  |   |

----