----

----

|   | ● | Additional Cost for work related to Case Report Form (CRF) design guidelines |
|--------|---------|------------------------------------------------------------------------------|
|   | ● | Edits and revisions for CRF version 2                                        |
|   | ● | Database and edit check programming in support of CRF version 2              |
|   | ● | Data Entry for 3,640 questionnaires                                          |
|   | ● | Additional queries and pages cleaned/monitored                               |
|   | ● | Quality Check (QC) of additional Safety Lab programming                      |
|   | ● | Programming of two biomarker labs.                                           |

|  INC Research Australia Pty Limited – 800089 | INC Research, LLC – CONFIDENTIAL |
|--------------------------------------------------------------|----------------------------------------|
|  Prana PBT2-204, Change Order #3 version 1              |                                   |

----

|   | ● | Statistical Analysis Plan updates to include expansion of analysis, editing, additional text, additional tables and listing shells. |
|--------|---------|-------------------------------------------------------------------------------------------------------------------------------------|
|   | ● | Additional analysis datasets to support increased analysis.                                                                         |
|   | ● | Addition of 22 Unique tables                                                                                                        |
|   | ● | Addition of 70 Repeat tables                                                                                                        |
|   | ● | Addition of 40 Listings                                                                                                             |
|   | ● | Addition of 190 analysis endpoints                                                                                                  |

|                 | Effective Date  | Direct CostsAUD$ | Indirect CostsAUD$ | Grand TotalAUD$ |
|----------------------|-----------------|------------------|--------------------|-----------------|
| Original Contract    | 18th April 2012 | $353,588.00      | $10,000.00         | $363,588.00     |
| Change Order # 1     | 19th July 2012  | $30,398.00       | $2,990.00          | $33,388.00      |
| Change Order # 2     | 29th July 2013  | $322,360.00      | $8,420.00          | $330,780.00     |
| Change Order #3      | Upon Execution  | $193,291.00      | $0.00              | $193,291.00     |
| Total Contract Value |            | $899,637.00      | $21,410.00         | $921,047.00     |

|   |    |                   |   |                                     |
|--------|---------|------------------------|--------|------------------------------------------|
|   | ● | Execution of Agreement | -      | Invoiced AUD $36,827.00 from original WO |
|   | ● | Database Complete      | -      | Invoiced AUD $36,827.00 from original WO |

|   |    |                       |   |                               |
|--------|---------|----------------------------|--------|------------------------------------|
|   | ● | 50% Data Entered           | -      | 25% of new total = AUD $114,148.00 |
|   | ● | 100% Data Entered          | -      | 25% of new total = AUD $114,148.00 |
|   | ● | Database Lock              | -      | 25% of new total = AUD $114,148.00 |
|   | ● | 1st Draft 1st Study Report | -      | 15% of new total = AUD $68,488.80  |
|   | ● | 1st Draft 2nd Study Report | -      | 5% of new total = AUD $22,829.60   |
|   | ● | Final Study Report         | -      | 5% of new total = AUD $22,829.60   |

|  INC Research Australia Pty Limited – 800089 | INC Research, LLC – CONFIDENTIAL |
|--------------------------------------------------------------|----------------------------------------|
|  Prana PBT2-204, Change Order #3 version 1              |                                   |

----

|                        |   |                                    |   |
|-----------------------------|--------|-----------------------------------------|--------|
| Prana Biotechnology Limited |   | INC Research Australia Pty Limited |   |
|                        |   |                                    |   |
|                             |   |                                    |   |
| Signature By:               |   | Signature By:                           |   |
| DIANNE ANGUS                |   |                                    |   |
| Name (print)                |   | Name (print)                            |   |
| Chief Operating Officer     |   |                                    |   |
| Title                       |   | Title                                   |   |
| 14 March 2014               |   |                                    |   |
| Date                        |   | Date                                    |   |

|  INC Research Australia Pty Limited – 800089 | INC Research, LLC – CONFIDENTIAL |
|--------------------------------------------------------------|----------------------------------------|
|  Prana PBT2-204, Change Order #3 version 1              |                                   |

----

|   | Service/Item                                           |   | Comments                                                                                                    |   | Unit Cost |   | WO & CO#1Numberof Units |   | CO#2 Numberof Units |   | CO#3 Number of Units |   | WO & CO#1Item Cost |   | CO#2Item Cost |   | CO#3 Item Cost |   | AUD$    |
|--------|--------------------------------------------------------|--------|-------------------------------------------------------------------------------------------------------------|--------|-----------|--------|-----------------------------|--------|---------------------|--------|----------------------|--------|-----------------------------|--------|---------------|--------|---------------------|--------|---------|
|   | Study Start Up Activities                              |   |                                                                                                        |   |      |   |                        |   |                |   |                 |   |                        |   |          |   |                |   |    |
|   | Study Training/ Internal Kick Off Meeting              |   | Familiarization, Protocol, IB, CRF, procedures etc.                                                         |   | 1080      |   | 1.00                        |   | 0.00                |   | 0.00                 |   | 1,080                       |   | 0             |   | 0                   |   |    |
|   | Study Training/ Internal Kick Off Meeting              |   | Familiarization, Protocol, IB, CRF, procedures etc.                                                         |   | 620       |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | Study Sponsorship                                      |   | Contract/insurance review, Indemnification                                                                  |   | 5000      |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | Study Manual/Monitoring Manual Development             |   | To be confirmed by client if required                                                                       |   | 3100      |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | List Trial on Public Register                          |   | e.g.. ACTR, Clintrials.gov                                                                                  |   | 310       |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | Investigator/Site Identification                       |   | Identify up to sites to select final 5                                                            |   | 540       |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | Clinical Trial Agreements                              |   | Negotiation / coordination with site                                                                        |   | 930       |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | Study Training                                         |   | Familiarization etc                                                                                         |   | 540       |   | 1.00                        |   | 0.00                |   | 0.00                 |   | 540                         |   | 0             |   | 0                   |   |    |
|   | Study Training on Protocol Amendment                   |   | Familiarization etc                                                                                         |   | 270       |   | 0.00                        |   | 2.00                |   | 0.00                 |   | 0                           |   | 540           |   | 0                   |   |    |
|   | Study Training on Protocol Amendment                   |   | Familiarization etc                                                                                         |   | 310       |   | 0.00                        |   | 1.00                |   | 0.00                 |   | 0                           |   | 310           |   | 0                   |   |    |
|   | Essential document collection                          |   | Creation, Collection and tracking                                                                           |   | 1350      |   | 5.00                        |   | 4.00                |   | 0.00                 |   | 6,750                       |   | 5,400         |   | 0                   |   |    |
|   | Ethics submissions - Australia                    |   | Per site includes application, customize IC/PI document, copying/collation, follow up with ethics questions |   | 1890      |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | Ethics submissions - New Zealand                       |   | Per site includes application, customize IC/PI document, copying/collation, follow up with ethics questions |   | 2160      |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | Regulatory Submissions - Australia                |   | Creation of CTN form and TGA liaison                                                                        |   | 270       |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | Regulatory Submissions - New Zealand              |   | Creation of SCOTT form and MedSafe liaison                                                                  |   | 810       |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | Regulatory Submissions Follow-up - New Zealand         |   | 6-monthly status reports and close out final report                                                         |   | 851       |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | Study Manual/Monitoring Manual Development   |   |                                                                                                        |   | 3100      |   | 1.00                        |   | 0.00                |   | 0.00                 |   | 3,100                       |   | 0             |   | 0                   |   |    |
|   | Study Files                                            |   | Set up of study master files and Investigator site files                                                    |   | 720       |   | 1.00                        |   | 1.00                |   | 0.00                 |   | 720                         |   | 720           |   | 0                   |   |    |
|   | File Management                                        |   | per month                                                                                                   |   | 283       |   | 24.00                       |   | 0.00                |   | 0.00                 |   | 6,787                       |   | 0             |   | 0                   |   |    |
|   | CRA Administration                                     |   | Communications - Customer, site, project Manager                                                            |   | 2903      |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | Import/Export Permit Handling                          |   | TGA/AQIS liaison, application, distribution                                                                 |   | 620       |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | Senior Management overview                             |   | Study status, issue resolution, client liaison                                                              |   | 0         |   | 0.00                        |   |                |   | 0.00                 |   | 0                           |   | 0             |   | 0                   |   |    |
|   | File Management - 2 new sites                          |   | per month from August 2012                                                                                  |   | 283       |   | 14.00                       |   | 0.00                |   | 0.00                 |   | 3,959                       |   | 0             |   | 0                   |   |    |
|   | File Management - 4 Sites                              |   | per month from October 2013                                                                            |   | 377       |   | 0.00                        |   | 14.00               |   | 0.00                 |   | 0                           |   | 5,279         |   | 0                   |   |    |
|   |                                                   |   |                                                                                                        |   |      |   |                        |   |                |   | Subtotal             |   | 22,937                      |   | 12,249        |   | 0                   |   | $35,186 |
|   | Customer Project Team Meetings                         |   |                                                                                                        |   |      |   |                        |   |                |   |                 |   |                        |   |          |   |                |   |    |
|   | Travel time                                            |   | 0 hours return                                                                                              |   | 0         |   | 0.00                        |   |                |   |                 |   | 0                           |   |          |   |                |   |    |
|   | Travel time                                            |   | 0 hours return                                                                                              |   | 0         |   | 1.00                        |   |                |   |                 |   | 0                           |   |          |   |                |   |    |
|   | Attendance                                             |   | Location                                                                                                    |   | 0         |   | 0.00                        |   |                |   |                 |   | 0                           |   |          |   |                |   |    |
|   | Attendance                                             |   | Location                                                                                                    |   | 0         |   | 1.00                        |   |                |   |                 |   | 0                           |   |          |   |                |   |    |
|   | Customer Kick-off Meeting                              |   | Teleconference                                                                                              |   | 0         |   | 0.00                        |   |                |   |                 |   | 0                           |   |          |   |                |   |    |
|   | Customer Kick-off Meeting                              |   | Teleconference                                                                                              |   | 0         |   | 0.00                        |   |                |   |                 |   | 0                           |   |          |   |                |   |    |
|   | Coordination of meeting                                |   |                                                                                                        |   | 90        |   | 0.00                        |   |                |   |                 |   | 0                           |   |          |   |                |   |    |
|   | Teleconference participation                           |   | 25 x 1 hour Telecon, 1 CRAs                                                                                 |   | 138       |   | 25.00                       |   | 0.00                |   | 0.00                 |   | 3,450                       |   | 0             |   | 0                   |   |    |
|   | Teleconference participation                           |   | 16 x monthly hour Telecon, 1 CRA                                                                            |   | 138       |   | 16.00                       |   | 0.00                |   | 0.00                 |   | 2,208                       |   | 0             |   | 0                   |   |    |
|   | Teleconference participation                           |   | 24 x fortnightly 1 hour Telecon, 2 CRAs                                                      |   | 276       |   | 0.00                        |   | 24.00               |   | 0.00                 |   | 0                           |   | 6,624         |   | 0                   |   |    |
|   | Teleconference participation                           |   | 24 x fortnightly 1 hour Telecon, 1 PM                                                   |   | 155       |   | 0.00                        |   | 24.00               |   | 0.00                 |   | 0                           |   | 3,720         |   | 0                   |   |    |
|   |                                                   |   |                                                                                                        |   |      |   |                        |   |                |   | Subtotal             |   | 5,658                       |   | 10,344        |   | 0                   |   | $16,002 |
|   | Investigator’s/Monitor’s Meeting           |   |                                                                                                        |   |      |   |                        |   |                |   |                 |   |                        |   |          |   |                |   |    |
|   | Preparation of presentations                           |   | Trident & Customer shared responsibility                                                                |   | 1620      |   | 1.00                        |   | 0.00                |   | 0.00                 |   | 1,620                       |   | 0             |   | 0                   |   |    |

| Prana Biotechnology Limited |                                   |   |
|-----------------------------|----------------------------------------|--------|
| Protocol #: PBT2-204        | INC Research, LLC – CONFIDENTIAL | 1      |
| INCR Project Code: 800089   |                                   |   |

----

|   | Travel time                                                                  |   | 0 hours return                                                                        |   | 0      |   | 0.00   |   |   |   | 0.00     |   | 0       |   | 0      |   | 0      |   |     |
|--------|------------------------------------------------------------------------------|--------|---------------------------------------------------------------------------------------|--------|--------|--------|--------|--------|--------|--------|----------|--------|---------|--------|--------|--------|--------|--------|----------|
|   | Travel time                                                                  |   | 0 hours return                                                                        |   | 0      |   | 1.00   |   |   |   | 0.00     |   | 0       |   | 0      |   | 0      |   |     |
|   | Attendance                                                                   |   | assume 1 day meeting, 0 PM                                                            |   | 1240   |   | 0.00   |   |   |   | 0.00     |   | 0       |   | 0      |   | 0      |   |     |
|   | Attendance                                                                   |   | assume 1 day meeting, 1 CRA                                                           |   | 1080   |   | 1.00   |   | 0.00   |   | 0.00     |   | 1,080   |   | 0      |   | 0      |   |     |
|   | Coordination of meeting                                                      |   | Mlg coordination, travel, dinner, binders, etc                                        |   | 155    |   | 0.00   |   |   |   |     |   | 0       |   |   |   |   |   |     |
|   | Coordination of meeting                                                      |   | Mlg coordination, travel, dinner, binders, etc                                        |   | 90     |   | 0.00   |   |   |   |     |   | 0       |   |   |   |   |   |     |
|   |                                                                         |   |                                                                                  |   |   |   |   |   |   |   | Subtotal |   | 2,700   |   | 0      |   | 0      |   | $2,700   |
|   | Site Visits                                                                  |   |                                                                                  |   |   |   |   |   |   |   |     |   |    |   |   |   |   |   |     |
|   | Additional Travel time for each round of site visits                         |   | 0 hours return                                                                        |   | 0      |   | 0.00   |   |   |   |     |   |    |   |   |   |   |   |     |
|   | Pre-Study Visits                                                             |   | Incl. prep, travel, on-site, reporting & follow-up                           |   | 1215   |   | 0.00   |   |   |   |     |   | 0       |   |   |   |   |   |     |
|   | Study Initiation                                                             |   | Incl. prep, travel, on-site, reporting & follow-up                           |   | 1620   |   | 5.00   |   | 0.00   |   | 0.00     |   | 8,100   |   | 0      |   | 0      |   |     |
|   | Study Initiation                                                             |   | Incl. prep, travel, on-site, reporting & follow-up                           |   | 1080   |   | 0.00   |   | 2.00   |   | 0.00     |   | 0       |   | 2,160  |   | 0      |   |     |
|   | Monitoring Visits (1 Day visits)                                             |   | Incl. prep, travel, 1 day on-site, reporting & follow-up 4 visits/site  |   | 1932   |   | 20.00  |   | 24.00  |   | 0.00     |   | 38,640  |   | 46,368 |   | 0      |   |     |
|   | Monitoring Visits(2Day visits)                                               |   | Incl. prep, travel, 2 days on-site, reporting & follow-up 3 visits/site |   | 3174   |   | 15.00  |   | 10.00  |   | 0.00     |   | 47,610  |   | 31,740 |   | 0      |   |     |
|   | Monitoring Visits (3 Day visits)                                             |   | Incl. prep, travel, 3 days on-site, reporting & follow-up 0 visits/site           |   | 4666   |   | 0.00   |   |   |   | 0.00     |   | 0       |   | 0      |   | 0      |   |     |
|   | Follow-up Monitoring Visits                                                  |   | Incl. prep, travel, on-site, reporting & follow-up 0 visits/site             |   | 146    |   | 0.00   |   |   |   | 0.00     |   | 0       |   | 0      |   | 0      |   |     |
|   | Unblinded Monitoring Visits                                                  |   | Incl. prep, travel, on-site, reporting & follow-up 0 visits/site             |   | 848    |   | 0.00   |   |   |   | 0.00     |   | 0       |   | 0      |   | 0      |   |     |
|   | Closeout visits                                                              |   | Incl. prep, travel, on-site, reporting & follow-up                           |   | 2070   |   | 5.00   |   | 0.00   |   | 0.00     |   | 10,350  |   | 0      |   | 0      |   |     |
|   | Closeout visits                                                              |   | Incl. prep, travel, on-site, reporting & follow-up                           |   | 1656   |   | 0.00   |   | 4.00   |   | 0.00     |   | 0       |   | 6,624  |   | 0      |   |     |
|   | Site Audit attendance                                                        |   | Incl. prep, travel, 1 day on-site, reporting & follow-up 0 visits            |   | 1845   |   | 0.00   |   |   |   |     |   | 0       |   |   |   |   |   |     |
|   |                                                                         |   |                                                                                  |   |   |   |   |   |   |   | Subtotal |   | 104,700 |   | 86,392 |   | 0      |   | $191,592 |
|   | Site Management:                                                        |   |                                                                                  |   |   |   |   |   |   |   |     |   |    |   |   |   |   |   |     |
|   | Site Management (October 2011 - Nov 2011)                                    |   | 1 site                                                                                |   | 593    |   | 2.00   |   | 0.00   |   | 0.00     |   | 1,187   |   | 0      |   | 0      |   |     |
|   | Site Management (Dec 2011 - May 2012)                                        |   | 2 sites                                                                               |   | 1187   |   | 6.00   |   | 0.00   |   | 0.00     |   | 7,121   |   | 0      |   | 0      |   |     |
|   | Site Management (June 2012 - July 2013)                                 |   | 3 sites                                                                               |   | 1780   |   | 14.00  |   | 0.00   |   | 0.00     |   | 24,923  |   | 0      |   | 0      |   |     |
|   | Site Management (August 2012 - July 2013)                                    |   | per month - 2 new sites                                                          |   | 1187   |   | 12.00  |   | 0.00   |   | 0.00     |   | 14,242  |   | 0      |   | 0      |   |     |
|   | Site Management (August 2013 - September 2013)                               |   | 3 sites                                                                               |   | 828    |   | 2.00   |   | 0.00   |   | 0.00     |   | 1,656   |   | 0      |   | 0      |   |     |
|   | Site Management (August 2013 - September 2013)                               |   | per month - 2 new sites                                                               |   | 552    |   | 2.00   |   | 0.00   |   | 0.00     |   | 1,104   |   | 0      |   | 0      |   |     |
|   | Site Management (October 2013 - November 2014)                               |   | per month - 4 Sites                                                                   |   | 2208   |   | 0.00   |   | 14.00  |   | 0.00     |   | 0       |   | 30,912 |   | 0      |   |     |
|   | Management/Supervision                                                       |   | per month                                                                             |   | 340    |   | 24.00  |   | 14.00  |   | 0.00     |   | 8,160   |   | 4,760  |   | 0      |   |     |
|   |                                                                         |   |                                                                                  |   |   |   |   |   |   |   | Subtotal |   | 58,392  |   | 35,672 |   | 0      |   | $94,064  |
|   | Project Management                                                           |   |                                                                                  |   |   |   |   |   |   |   |     |   |    |   |   |   |   |   |     |
|   | Local coordination/supervision (June 2011 - August 2011)                     |   | per month                                                                             |   | 3100   |   | 0.00   |   |   |   |     |   | 0       |   |   |   |   |   |     |
|   | Local coordination/supervision (August 2011 - May ***) Biotechnology Limited |   | per month                                                                             |   | 1580   |   | 0.00   |   |   |   |     |   | 0       |   |   |   |   |   |     |
|   | File Management                                                              |   | per month                                                                             |   | 471    |   | 0.00   |   |   |   |     |   | 0       |   |   |   |   |   |     |

| Prana Biotechnology Limited |                                   |   |
|-----------------------------|----------------------------------------|--------|
| Protocol #: PBT2-204        | INC Research, LLC – CONFIDENTIAL | 2      |
| INCR Project Code: 800089   |                                   |   |

----

|   | Administer Site Payments                                  |   |   | per site                                                                                                                       |   |   | 3448      |   |   | 0.00        |   |   |        |   |   |       |   |   | 0           |   |   |        |   |   |    |   |   |    |   |
|--------|-----------------------------------------------------------|--------|--------|--------------------------------------------------------------------------------------------------------------------------------|--------|--------|-----------|--------|--------|-------------|--------|--------|-------------|--------|--------|------------|--------|--------|-------------|--------|--------|-------------|--------|--------|---------|--------|--------|---------|--------|
|   | Teleconference participation with client/PM               |   |   | 0 x 1 hour Sponsor Telecon, and 0 x 1 hour Team Tetecon                                                                        |   |   | 158       |   |   | 0.00        |   |   |        |   |   |       |   |   | 0           |   |   |        |   |   |    |   |   |    |   |
|   | Project Status Reporting                                  |   |   | per month                                                                                                                      |   |   | 163       |   |   | 0.00        |   |   |        |   |   |       |   |   | 0           |   |   |        |   |   |    |   |   |    |   |
|   | Project Assistance (June 2011 - July 2013)                |   |   | per month                                                                                                                      |   |   | 378       |   |   | 0.00        |   |   |        |   |   |       |   |   | 0           |   |   |        |   |   |    |   |   |    |   |
|   |                                                      |   |   |                                                                                                                           |   |   |      |   |   |        |   |   |        |   |   |       |   |   | Subtotal    |   |   |        |   |   |    |   |   | $0      |   |
|   | Safety Monitoring                                         |   |   |                                                                                                                           |   |   |      |   |   |        |   |   |        |   |   |       |   |   |        |   |   |        |   |   |    |   |   |    |   |
|   | Familiarization and Set up                                |   |   |                                                                                                                           |   |   | 1280      |   |   | 1.00        |   |   |        |   |   |       |   |   | 1,280       |   |   |        |   |   |    |   |   |    |   |
|   |  Study Completion                                    |   |   |  Archiving, collation and client correspondence                                                                           |   |   |  501 |   |   |  1.00  |   |   |        |   |   |       |   |   |  501   |   |   |        |   |   |    |   |   |    |   |
|   |  Study administration (first 6 months)               |   |   |  Correspondence, tracking, client liaison, filing                                                                         |   |   |  160 |   |   |  6.00  |   |   |        |   |   |       |   |   |  960   |   |   |        |   |   |    |   |   |    |   |
|   |  Study administration (XXXX - XXXX)                  |   |   |  Correspondence, tracking, client liaison, filing                                                                         |   |   |  83  |   |   |  15.00 |   |   |        |   |   |       |   |   |  1,238 |   |   |        |   |   |    |   |   |    |   |
|   | Safety Administration                                     |   |   | Incl. set up, maintenance and completionactivities                                                                             |   |   | 3979      |   |   | 1.00        |   |   | 0.00        |   |   | 0.00       |   |   | 3,979       |   |   | 0           |   |   | 0       |   |   |    |   |
|   | Safety Administration                                     |   |   | Study Extension                                                                                                                |   |   | 83        |   |   | 0.00        |   |   | 14.00       |   |   | 0.00       |   |   | 0           |   |   | 1,155       |   |   | 0       |   |   |    |   |
|   | Initial Receipt and handling SAEs                         |   |   | All events- assume 1 SAE                                                                                                       |   |   | 330       |   |   | 1.00        |   |   | 10.00       |   |   | 0.00       |   |   | 330         |   |   | 3,300       |   |   | 0       |   |   |    |   |
|   | Medical Review of SAEs and Narrative creation             |   |   | Optional - as required                                                                                                         |   |   | 838       |   |   | 0.00        |   |   | 10.00       |   |   | 0.00       |   |   | 0           |   |   | 8,380       |   |   | 0       |   |   |    |   |
|   | Reporting to local Authorities                            |   |   | Assume 1 Reportable events                                                                                                     |   |   | 860       |   |   | 1.00        |   |   | 10.00       |   |   | 0.00       |   |   | 660         |   |   | 6,600       |   |   | 0       |   |   |    |   |
|   |  Follow up of SAEs                                   |   |   |  Assume 2 hours/Follow-up/SAE. 1 Follow-ups                                                                               |   |   |  330 |   |   |  1.00  |   |   |  10.00 |   |   |  0.00 |   |   |  330   |   |   |  3,300 |   |   |  0 |   |   |    |   |
|   | Investigator Notification Letters                         |   |   | preparation and oversight                                                                                                      |   |   | 165       |   |   | 1.00        |   |   | 10.00       |   |   | 0.00       |   |   | 165         |   |   | 1,650       |   |   | 0       |   |   |    |   |
|   | Medical Monitor                                           |   |   | only if required                                                                                                               |   |   | 419       |   |   | 0.00        |   |   |        |   |   |       |   |   | 0           |   |   |        |   |   |    |   |   |    |   |
|   | Set Up DSMB Charter                                       |   |   |                                                                                                                           |   |   | 1257      |   |   | 0.00        |   |   |        |   |   |       |   |   | 0           |   |   |        |   |   |    |   |   |    |   |
|   | Attend DSMB meetings (via teleconference)                 |   |   | assume 1 hr meetings x 2 meetings                                                                                              |   |   | 168       |   |   | 0.00        |   |   |        |   |   |       |   |   | 0           |   |   |        |   |   |    |   |   |    |   |
|   | Prepare Minutes/Reports from DSMB meetings                |   |   |                                                                                                                           |   |   | 670       |   |   | 0.00        |   |   |        |   |   |       |   |   | 0           |   |   |        |   |   |    |   |   |    |   |
|   |                                                      |   |   |                                                                                                                           |   |   |      |   |   |        |   |   |        |   |   | Subtotal   |   |   | 5,464       |   |   | 24,385      |   |   | 0       |   |   | $29,848 |   |
|   | Data Management & Statistics                          |   |   |                                                                                                                           |   |   |      |   |   |        |   |   |        |   |   |       |   |   |        |   |   |        |   |   |    |   |   |    |   |
|   | CRF Design                                                |   |   | 25 unique pages. 80 pages of CRF and 11pages of questionnaire 91 Total pages. One print run.                                   |   |   | 14520     |   |   | 1.00        |   |   | 0.00        |   |   | 0.00       |   |   | 14,520      |   |   | 0           |   |   | 0       |   |   |    |   |
|   | CRF Design                                                |   |   | CRF design guidelines                                                                                                          |   |   | 85        |   |   | 0.00        |   |   | 0.00        |   |   | 16.00      |   |   | 0           |   |   | 0           |   |   | 1,360   |   |   |    |   |
|   | CRF Design                                                |   |   | Edits and revisions for version 2                                                                                              |   |   | 120       |   |   | 000         |   |   | 0.00        |   |   | 16.00      |   |   | 0           |   |   | 0           |   |   | 1,920   |   |   |    |   |
|   | CRF Design (extension)                                    |   |   | 80 pages of CRF (70 on average entered ) One print run.                                                                        |   |   | 2834      |   |   | 0.00        |   |   | 1.00        |   |   | 0.00       |   |   | 0           |   |   | 2,834       |   |   | 0       |   |   |    |   |
|   | Database design and build                                 |   |   |                                                                                                                           |   |   | 463       |   |   | 25.00       |   |   | 0.00        |   |   | 0.00       |   |   | 11,563      |   |   | 0           |   |   | 0       |   |   |    |   |
|   | Database design and build (extension)                     |   |   |                                                                                                                           |   |   | 57        |   |   | 0.00        |   |   | 25.00       |   |   | 0.00       |   |   | 0           |   |   | 1,429       |   |   | 0       |   |   |    |   |
|   | Database / Consistency Check programming                  |   |   |                                                                                                                           |   |   | 53        |   |   | 208.25      |   |   | 0.00        |   |   | 0.00       |   |   | 11,114      |   |   | 0           |   |   | 0       |   |   |    |   |
|   | Database / Consistency Check programming                  |   |   | Database and edit check programming insupport of version 2                                                                     |   |   | 120       |   |   | 0.00        |   |   | 0.00        |   |   | 24.00      |   |   | 0           |   |   | 0           |   |   | 2,880   |   |   |    |   |
|   | Database / Consistency Check programmingextension)        |   |   |                                                                                                                           |   |   | 33        |   |   | 0.00        |   |   | 202.00      |   |   | 0.00       |   |   | 0           |   |   | 6,676       |   |   | 0       |   |   |    |   |
|   |  Data Validation Manual / Data Management Plan       |   |   |                                                                                                                           |   |   | 3400      |   |   | 1.00        |   |   | 0.00        |   |   | 0.00       |   |   | 3,400       |   |   | 0           |   |   | 0       |   |   |    |   |
|   | Data Validation Manual / Data Management Plan (extension) |   |   |                                                                                                                           |   |   | 1664      |   |   | 0.00        |   |   | 1.00        |   |   | 0.00       |   |   | 0           |   |   | 1,664       |   |   | 0       |   |   |    |   |
|   | Data entry                                                |   |   |  Double Data Entry 40 patients x 80 CRF pages plus 40 x 11 questionnaires=3640 tolal pages. Cost per extra page=5.87 |   |   | 6         |   |   | 3640.00     |   |   | 0.00        |   |   | 294.00     |   |   | 21,385      |   |   | 0           |   |   | 1,727   |   |   |    |   |

| Prana Biotechnology Limited |                                   |   |
|-----------------------------|----------------------------------------|--------|
| Protocol #: PBT2-204        | INC Research, LLC – CONFIDENTIAL | 3      |
| INCR Project Code: 800089   |                                   |   |

----

|   | Revised Total Budget                                      |
|--------|-----------------------------------------------------------|
|   | Data entry (extension)                                    |   | Double Data Entry 33 patients x 70 entered CRF pages 2310 total pages. Cost per extra page=36.26 | 6 | 0.00 | 2310.00 | 0.00 | 0 | 14,453 | 0 |   |
|   | Medical Coding                                       |   | MedDRA-AE, WHO - Drug  | 6 | 800.00 | 0.00 | 0.00 | 5,036 | 0 | 0 |   |
|   | Medical Coding (extension)                           |   | MedDRA-AE, WHO - Drug  | 7 | 0.00 | 660.00 | 0.00 | 0 | 4,600 | 0 |   |
|   | Data Cleaning / Monitoring                           |   | 3200 CRF pages. Cost per extra page=$5.10 224 Queries. Cost per extra query=$42.50 | 29617 | 1.00 | 0.00 | 0.00 | 29,617 | 0 | 0 |   |
|   | Data Cleaning / Monitoring                           |   | Additional pages cleaned/monitored | 5.10 | 0.00 | 0.00 | 734.00 | 0 | 0 | 3,743 |   |
|   | Data Cleaning / Monitoring                           |   | Additional queries raised | 42.50 | 0.00 | 0.00 | 646.00 | 0 | 0 | 27,455 |   |
|   | Data Cleaning / Monitoring (Extension)                    |   | 2310 CRF pages. Cost per extra page=$7.00 162 Queries. Cost per extra query=$52.00 | 26270 | 0.00 | 1.00 | 0.00 | 0 | 26,270 | 0 |   |
|   | Quality Control                                           |   | 10% of all patients, 100% of all critical data (15% critical /85% non critical) | 2.95 | 811.40 | 0.00 | 0.00 | 2,391 | 0 | 0 |   |
|   | Quality Control                                           |   | Additional Safety Lab QC programming | 120 | 0.00 | 0.00 | 4.00 | 0 | 0 | 480 |   |
|   | Quality Control                                           |   | Additional Safety Lab QC (pages) | 2.81 | 0.00 | 0.00 | 91.00 | 0 | 0 | 256 |   |
|   | Quality Control (extension)                               |   | 10% of all patients, 100% of all critical data (15% critical / 85% non critical) | 3.34 | 0.00 | 543.00 | 0.00 | 0 | 1,813 | 0 |   |
|   | Import laboratory data                                    |   | 1 central lab | 3680 | 1.00 | 0.00 | 0.00 | 3,680 | 0 | 0 |   |
|   | Import laboratory data                               |   | 2 biomarker labs -programming | 120 | 0.00 | 0.00 | 6.00 | 0 | 0 | 720 |   |
|   | Import laboratory data                                    |   | 2 biomarker labs -data review | 85 | 0.00 | 0.00 | 6.00 | 0 | 0 | 510 |   |
|   | Import laboratory data (extension)                        |   | 1 central lab. Import and review | 3182 | 0.00 | 1.00 | 0.00 | 0 | 3,182 | 0 |   |
|   | Data exports                                              |   | Assume 2 exports | 360 | 200 | 0.00 | 0.00 | 720 | 0 | 0 |   |
|   | Data exports (extension)                                  |   | Assume 2 exports | 327 | 0.00 | 2.00 | 0.00 | 0 | 054 | 0 |   |
|   | Database maintenance                                      |   | Study Duration = 18 months | 240 | 18.00 | 0.00 | 0.00 | 4,320 | 0 | 0 |   |
|   | Database maintenance (extension)                          |   | Study Duration = 18 months | 218 | 0.00 | 18.00 | 0.00 | 0 | 3,924 | 0 |   |
|   | DM & Statisties - Project Management             |   | Client meetings & corresp, DM metrics 1hrs/month x 18 months | 120 | 16.00 | 0.00 | 0.00 | 1,530 | 0 | 0 |   |
|   | DM & Statisties - Project Management (extension) |   | Client meetings & corresp, DM metrics 1hrs/month x 18 months | 104 | 0.00 | 18.00 | 0.00 | 0 | 1,872 | 0 |   |
|   | Input to protocol                                         |   | Text and sample size calculation / power | 200 | 4.00 | 0.00 | 0.00 | 800 | 0 | 0 |   |
|   | Generation of Randomisation schedule                      |   | envelope $12.50 | 1175 | 1.00 | 0.00 | 0.00 | 1,175 | 0 | 0 |   |
|   | Statistical Analysis Plan                                 |   | Includes text and table and listing shells. | 5840 | 1.00 | 0.00 | 0.00 | 5,840 | 0 | 0 |   |
|   | Statistical Analysis Plan                                 |   |  Additional hours to cover expansion of analysis. Includes discussion, editing, additional text additional tables and listing shells. | 200 | 0.00 | 0.00 | 116.00 | 0 | 0 | 23,200 |   |
|   | Statistical Analysis Plan                                 |   |  Adaption of SAP for extension and combined analysis. Includes text plus table & listing shells | 6072 | 0.00 | 1.00 | 0.00 | 0 | 6,072 | 0 |   |
|   | populations                                               |   | populations | 1600 | 1.00 | 0.00 | 0.00 | 1,600 | 0 | 0 |   |
|   | (extension)Analysis populations                           |   | populations | 1600 | 0.00 | 1.00 | 0.00 | 0 | 1,600 | 0 |   |
|   | Analysis Datasets                                         |   | Specification, Programming & QC | 4800 | 1.00 | 0.00 | 0.00 | 4,800 | 0 | 0 |   |
|   | Analysis Datasets                                         |   | Additional analysis datasets to support increased analysis | 600 | 0.00 | 0.00 | 14.00 | 0 | 0 | 8,400 |   |
|   | Analysis Datasets (extension)                             |   | Specification, Programming & QC | 3936 | 0.00 | 1.00 | 0.00 | 0 | 3,936 | 0 |   |
|   | Production of Tables & Listings                       |   | 15 Unique tables. Cost per extra $720 20 Repeat tables. Cost per extra $2400 Figures. Cost per extra $42035 Listings. Cost per extra $300 | 26100 | 1.00 | 0.00 | 0.00 | 26,100 | 0 | 0 |   |

| Prana Biotechnology Limited |                                   |   |
|-----------------------------|----------------------------------------|--------|
| Protocol #: PBT2-204        | INC Research, LLC – CONFIDENTIAL | 4      |
| INCR Project Code: 800089   |                                   |   |

----

|   | Production of Tables & Listings             |   | 22 Unique tables. Cost per extra $72070 Repeat tables. Cost per extra $2400 Figures. Cost per extra $42040 Listings. Cost per extra $300 |   | 44640  | 0.00   | 0.00   | 1.00     | 0       | 0       | 44,640  |           |
|--------|-------------------------------------------------|--------|------------------------------------------------------------------------------------------------------------------------------------------|--------|--------|--------|--------|----------|---------|---------|---------|----------------|
|   | Production of Tables & Listings (extension) |   | 2 Unique tables. Cost per extra $72068 Repeat tables. Cost per extra $2400 Figures. Cost per extra $42035 Listings. Cost per extra $300  |   | 38622  | 0.00   | 1.00   | 0.00     | 0       | 38,622  | 0       |           |
|   | Statistical Analysis                            |   | 10 analysis endpoints. Cost per extra $400                                                                                               |   | 400    | 10.00  | 0.00   | 190.00   | 4,000   | 0       | 76,000  |           |
|   | Statistical Analysis (extension)                |   | 10 analysis endpoints. Cost per extra $424                                                                                               |   | 424    | 0.00   | 10.00  | 0.00     | 0       | 4,240   | 0       |           |
|   | Provision of data to DSMB                       |   | Assumes Interim running and QC of 6 TFLs in now Programming Tables and listings.                                                    |   | 960    | 3.00   | 0.00   | 0.00     | 2,880   | 0       | 0       |           |
|   | Provision of data to DSMB (extension)           |   | Assumes provision of excel spreadsheets and graphed laboratory values                                                                    |   | 1312   | 0.00   | 3.00   | 0.00     | 0       | 3,936   | 0       |           |
|   | Input to Final report                           |   | Text for Inclusion in study report.                                                                                                      |   | 2400   | 1.00   | 0.00   | 0.00     | 2,400   | 0       | 0       |           |
|   | Input to Final report (extension)               |   | Text for Inclusion in study report.                                                                                                      |   | 2544   | 0.00   | 1.00   | 0.00     | 0       | 2,544   | 0       |           |
|   |                                            |   |                                                                                                                                     |   |   |   |   | Subtotal | 158,869 | 130,321 | 193,291 | $482,482  |
|   | Medical Writing (Optional)                      |   |                                                                                                                                     |   |   |   |   |     |    |    |    |           |
|   | Clinical study report (CSR)                     |   |                                                                                                                                     |   | 22497  | 1.00   | 1.00   | 0.00     | 22,497  | 22,497  | 0       |           |
|   | QA review of CSR                                |   | Optional for Client                                                                                                                      |   | 2769   | 1.00   | 0.00   | 0.00     | 2,769   | 0       | 0       |           |
|   |                                            |   |                                                                                                                                     |   |   |   |   | Subtotal | 25,266  | 22,497  | 0       | $47,763   |
|   |                                            |   |                                                                                                                                     |   |   |   |   |     |    |    |    |           |
|   |                                            |   |                                                                                                                                     |   |   |   |   | TOTAL    | 383,986 | 322,360 | 193,291 | $899,637  |

| INCR Project Code: 800089 | INC Research, LLC – CONFIDENTIAL | 5 |
|---------------------------|----------------------------------------|---|

----

|   | Expense/Item                                                                                |   |   | Comments                                            |   |   | Unit Cost  |   |   | WO & CO#1 Number of Units |   |   | CO#2 Number of Units |   |   | WO & CO#1Item Cost AUD$ |   |   | CO#2 Item Cost AUD$ |   |   | CO#3 Item Cost AUD$ |   |   | AUD$    |   |
|--------|---------------------------------------------------------------------------------------------|--------|--------|-----------------------------------------------------|--------|--------|------------|--------|--------|-------------------------------|--------|--------|----------------------|--------|--------|----------------------------------|--------|--------|---------------------|--------|--------|---------------------|--------|--------|---------|--------|
|   | Site Visits                                                                                 |   |   |                                                |   |   |       |   |   |                          |   |   |                 |   |   |                             |   |   |                |   |   |                |   |   |    |   |
|   | Other Site visit Costs                                                                      |   |   | Parking/tolls/meals and incidentals for site visits |   |   | $50/day    |   |   | 60.00                         |   |   | 50.00                |   |   | 3,000                            |   |   | 2,500               |   |   | 0                   |   |   |    |   |
|   |                                                                                        |   |   |                                                |   |   |       |   |   |                          |   |   | Subtotal             |   |   | 3,000                            |   |   | 2,500               |   |   | 0                   |   |   | $5,500  |   |
|   | General Expenses                                                                            |   |   |                                                |   |   |       |   |   |                          |   |   |                 |   |   |                             |   |   |                |   |   |                |   |   |    |   |
|   |  General Expenses - Couriers, Postage, Telecommunications, Copying, stationery (files) |   |   | $70/site/month, 3 sites for 25 months               |   |   | S210/month |   |   | 25                            |   |   | 0.00                 |   |   | 5,250                            |   |   | 0                   |   |   | 0                   |   |   |    |   |
|   |  General Expenses - Couriers, Postage,Telecommunications, Copying, stationery (files)  |   |   | $70/site/month, 2 new sites for 16 months           |   |   | $140/month |   |   | 16                            |   |   | 0.00                 |   |   | 2,240                            |   |   | 0                   |   |   | 0                   |   |   |    |   |
|   |  General Expenses - Couriers, Postage,Telecommunications, Copying, stationery (files)  |   |   | $70/site/month, 4 sites for 14 months          |   |   | $280/month |   |   | 0                             |   |   | 14.00                |   |   | 0                                |   |   | 3,920               |   |   | 0                   |   |   |    |   |
|   |  CRF Printing                                                                          |   |   |                                                |   |   | $2,500     |   |   | 1                             |   |   | 1.00                 |   |   | 2,500                            |   |   | 2,000               |   |   | 0                   |   |   |    |   |
|   |                                                                                        |   |   |                                                |   |   |       |   |   |                          |   |   | Subtotal             |   |   | 9,990                            |   |   | 5,920               |   |   | 0                   |   |   | $15,910 |   |
|   |                                                                                        |   |   |                                                |   |   |       |   |   |                          |   |   |                 |   |   |                             |   |   |                |   |   |                |   |   |    |   |
|   |                                                                                        |   |   |                                                |   |   |       |   |   |                          |   |   | TOTAL                |   |   | 12,990                           |   |   | 8,420               |   |   | 0                   |   |   | $21,410 |   |

| Prana Biotechnology Limited Protocol #: PBT2-204 INCR Project Code: 800089 | INC Research, LLC – CONFIDENTIAL | 1 |
|----------------------------------------------------------------------------|----------------------------------------|---|

----

|  INC Research Australia Pty Limited – 800089 | INC Research, LLC – CONFIDENTIAL |
|--------------------------------------------------------------|----------------------------------------|
|  Prana PBT2-204, Change Order #4 version 1              |                                   |

----

|                 | ***             | ***         | ***        | ***         |
|----------------------|-----------------|-------------|------------|-------------|
| Original Contract    | 18th April 2012 | $353,588.00 | $10,000.00 | $363,588.00 |
| Change Order #1      | 19th July 2012  | $30,398.00  | $2,990.00  | $33,388.00  |
| Change Order # 2     | 29th July 2013  | $322,360.00 | $8,420.00  | $330,780.00 |
| Change Order #3      | 18 March 2014   | $193,291.00 | $0.00      | $193,291.00 |
| Change Order #4      | Upon Execution  | $1,440.00   | $0,00      | $1,440.00   |
| Total Contract Value |            | $901,077.00 | $21,410.00 | $922,487.00 |

|    |                   |   |                                     |
|---------|------------------------|--------|------------------------------------------|
| ● | Execution of Agreement | -      | Invoiced AUD $36,827.00 from original WO |
| ● | Database Complete      | -      | Invoiced AUD $36,827.00 from original WO |
|    |                       |   |                               |
|---------|----------------------------|--------|------------------------------------|
| ● | 50% Data Entered           | -      | 25% of new total = AUD $114,508.00 |
| ● | 100% Data Entered          | -      | 25% of new total = AUD $114,508.00 |
| ● | Database lock              | -      | 25% of new total = AUD $114,508.00 |
| ● | 1st Draft 1st Study Report | -      | 15% of new total = AUD $68,704.80  |
| ● | 1st Draft 2nd Study Report | -      | 5% of new total = AUD $22,901.60   |
| ● | Final Study Report         | -      | 5% of new total = AUD $22,901.60   |

|  INC Research Australia Pty Limited– 800089 | INC Research, LLC – CONFIDENTIAL |
|------------------------------------------------------------------|---------------------------------------------|
|  Prana PBT2-204, Change Order #4 version 1                  |                                        |

----

|                        |             |                                    |          |                                       |   |
|-----------------------------|------------------|-----------------------------------------|---------------|--------------------------------------------|--------|
| Prana Biotechnology Limited |             | INC Research Australia Pty Limited |          |
|                             |             |                                         |          |
| Signature By:          | GEOFFREY KEMPLER |                                    | Signature By: | David Fuller                               |   |
| Name (print)                |             |                                    | Name (print)  | Senior Vice President Clinical Development |   |
| Title                  | CEO              |                                    | Title         | 11thJuly 2014                              |   |
| Date                   | 1st July 2014    |                                    | Date          |                                       |   |

|  INC Research Australia Pty Limited– 800089 | INC Research, LLC – CONFIDENTIAL |
|-------------------------------------------------------------|---------------------------------------------|
|  Prana PBT2-204, Change Order #4 version 1             |                                        |

----

| ***                                            |   | ***                                                                                |   | ***    |   | ***        |   | ***    |   | ***             |   | ***    |   | ***         |   | ***     |   | ***     |   | ***    |   | ***          |
|------------------------------------------------|--------|------------------------------------------------------------------------------------|--------|--------|--------|------------|--------|--------|--------|-----------------|--------|--------|--------|-------------|--------|---------|--------|---------|--------|--------|--------|--------------|
| Study Start Up/***                             |   |                                                                               |   |   |   |       |   |   |   |            |   |   |   |        |   |    |   |    |   |   |   |         |
| Study Training/ Internal Kick Off Meeting      |   | ***Protocol, IB, CRF, procedures etc.                                              |   | 1080   |   | 1.00       |   | 0.00   |   | 0.00            |   |   |   | 1,080       |   | 0       |   | 0       |   |   |   |         |
| Study Training                                 |   | *** etc                                                                            |   | 840    |   | 1.00       |   | 0.00   |   | 0.00            |   |   |   | 540         |   | 0       |   | 0       |   |   |   |         |
| Study Training on Protocol Amendment           |   | *** etc                                                                            |   | 270    |   |  0.00 |   | 2.00   |   | 0.00            |   |   |   | 0           |   | 540     |   | 0       |   |   |   |         |
| Study Trainig on Protocol Amendment       |   | *** etc                                                                            |   | 310    |   | 0.00       |   | 1.00   |   | 0.00            |   |   |   | 0           |   | 310     |   | 0       |   |   |   |         |
| Essential document collection                  |   | Creuton, Collection and tracloting                                                 |   | 1350   |   | 6.00       |   | 400    |   | 0.00            |   |   |   | 6,750       |   | 5,400   |   | 0       |   |   |   |         |
| Study Manual/Monitoring Manual Development     |   |                                                                               |   | 3100   |   | 1:00       |   | 0.00   |   | 0.00            |   |   |   | 3,100       |   | 0       |   | 0       |   |   |   |         |
| Study Files                                    |   | Set up of study master files and Investigator *he files                            |   | 720    |   | 1.00       |   | 1.00   |   | 0.00            |   |   |   | 720         |   | 720     |   | 0       |   |   |   |         |
| File Management                                |   | per month                                                                          |   | 283    |   | 24.00      |   | 0.00   |   | 0.00            |   |   |   | 6,787       |   | 0       |   | 0       |   |   |   |         |
| File Management - 2 new sites             |   | per month from August 2012                                                         |   | 283    |   | 14.00      |   | 0.00   |   | 0.00            |   |   |   | 3,959       |   | 0       |   | 0       |   |   |   |         |
| File Management - 4 sites                      |   | per month fromOctober 2013                                                    |   | 377    |   | 0.00       |   | 14.00  |   | 0.00            |   |   |   | 0           |   | 6,279   |   | 0       |   |   |   |         |
|                                           |   |                                                                               |   |   |   |       |   |   |   | Subtotal   |   |   |   | 22,837      |   | 12,249  |   | 0       |   |   |   | ***          |
| ***                                            |   |                                                                               |   |   |   |       |   |   |   |            |   |   |   |        |   |    |   |    |   |   |   |         |
| Teleconference  participation        |   | 25 x 1 hour Telecon, 1 CRAs                                                        |   | 138    |   | 26.00      |   | 0.00   |   | 0.00            |   |   |   | 3,450       |   | 0       |   | 0       |   |   |   |         |
| Teleconference  participation        |   | 16 x monthly hour Telecon, 1 CRA                                                   |   | 138    |   | 16.00      |   | 0.00   |   | 0.00            |   |   |   | 2,208       |   | 0       |   | 0       |   |   |   |         |
| Teleconference participation                   |   | 24 x *** 1 hour Telecon, 2 CRAs.                                                   |   | 276    |   | 0.00       |   | 24.00  |   | 0.00            |   |   |   | 0           |   | 6,624   |   | 0       |   |   |   |         |
| Teleconference participation                   |   | 24 x *** 1 hour Telecon, 1 PM                                                      |   | 155    |   | 0.00       |   | 24.00  |   | 0.00            |   |   |   | 0           |   | 3,720   |   | 0       |   |   |   |         |
|                                           |   |                                                                               |   |   |   |       |   |   |   | Subtotal        |   |   |   | 5,654  |   | 10,344  |   |    |   |   |   | $16,002      |
| ***                                            |   |                                                                               |   |   |   |       |   |   |   |            |   |   |   |        |   |    |   |    |   |   |   |         |
| Preparation of Presentations                   |   | Trident & Customer shared responsibilty                                        |   | 1620   |   | 1.00       |   | 0.00   |   | 0.00            |   |   |   | 1,820       |   | 0       |   | 0       |   |   |   |         |
| Attendance                                     |   | *** 1 day meeting, 1. CRA                                                          |   | 1080   |   | 1.00       |   | 0,00   |   | 0.00            |   |   |   | 1,080       |   | 0       |   | 0       |   |   |   |         |
|                                           |   |                                                                               |   |   |   |       |   |   |   |            |   |   |   |  2,760 |   |  0 |   | 0  |   |   |   |  $2,700 |
| Site Visits                                    |   |                                                                               |   |   |   |       |   |   |   |            |   |   |   |        |   |    |   |    |   |   |   |         |
| Sutdy Initiation                               |   | Incl. prop, travel, on-site, reporting & follow-up                             |   | 1620   |   | 5.00       |   | 0.00   |   | 0.00            |   |   |   | 8,100       |   | 0       |   | 0       |   |   |   |         |
| Study Initiation                               |   | Incl. prop, travel, on-site, reporting & follow-up                             |   | 1080   |   | 0.00       |   | 2.00   |   | 0.00            |   |   |   | 0           |   | 2,160   |   | 0       |   |   |   |         |
| Monitoring Visits  (1 Day visits)    |   | Incl. prop, travel, 1 day on-site, reporting & follow-up 4 visits/site         |   | 1932   |   | 20.00      |   | 24.00  |   | 0.00            |   |   |   | 38,640      |   | 46,366  |   | 0       |   |   |   |         |
| Monitoring visits (2 Day visits)          |   | Incl. prop, travel, 2 day’s on-site, reporting & follow-up 3 visits/site |   | 3174   |   | 15.00      |   | 10.00  |   | 0.00            |   |   |   | 47,610      |   | 31,740  |   | 0       |   |   |   |         |
| Closeout visits                                |   | Incl. prop, travel, on-site, reporting & follow-up                             |   | 2070   |   | 5.00       |   | 0.00   |   | 0.00            |   |   |   | 10,350      |   | 0       |   | 0       |   |   |   |         |
| Closeout visits                                |   | Incl. prep, travel, on-site, reporting & follow-up                        |   | 1656   |   | 0.00       |   | 4.00   |   | 0.00            |   |   |   | 0           |   | 6,824   |   | 0       |   |   |   |         |
|                                           |   |                                                                               |   |   |   |       |   |   |   |   Subtotal |   |   |   | 164,700     |   | ***     |   | 0       |   |   |   | $101,502     |
| Site Management                                |   |                                                                               |   |   |   |       |   |   |   |            |   |   |   |        |   |    |   |    |   |   |   |         |
|                                           |   |                                                                               |   |   |   |       |   |   |   |            |   |   |   |        |   |    |   |    |   |   |   |         |
| Site Management (October 2011 -Nov 2011)       |   | 1 site                                                                             |   | 593    |   | 2.00       |   | 0.00   |   | 0.00            |   |   |   | 1,187       |   | 0       |   | 0       |   |   |   |         |
| Site Management (Dec 2011 - May 2012)          |   | 2 sites                                                                            |   | 1187   |   | 6.00       |   | 0.00   |   | 0.00            |   |   |   | 7,121       |   | 0       |   | 0       |   |   |   |         |
| Site Management (June 2012- July 2013)         |   | 3 sites                                                                            |   | 1780   |   | 14.00      |   | 0.00   |   | 0.00            |   |   |   | 24,923      |   | 0       |   | 0       |   |   |   |         |
| Site Management August 2012 - July 2013)       |   | per month - 2 new sites                                                            |   | 1187   |   | 12.00      |   | 0.00   |   | 0.00            |   |   |   | 14,242      |   | 0       |   | 0       |   |   |   |         |
| Site Management (August 2013 - September 2013) |   | 3 sites                                                                            |   | 828    |   | 2.00       |   | 0.00   |   | 0.00            |   |   |   | 1,858       |   | 0       |   | 0       |   |   |   |         |
| Site Management (August 2013 - September 2013) |   | per month - 2 now sites                                                       |   | 552    |   | 2.00       |   | 0.00   |   | 0.00            |   |   |   | 1,104       |   | 0       |   | 0       |   |   |   |         |
| Site Management (October 2013 - November 2014) |   | per month - 4sites                                                                 |   | 2208   |   | 0.00       |   | 14,00  |   | 0.00            |   |   |   | 0           |   | 30,912  |   | 0       |   |   |   |         |
| Management/Supervision                         |   | per month                                                                          |   | 340    |   | 24.00      |   | 14.00  |   | 0.00            |   |   |   | 8,160       |   | 4,760   |   | 0       |   |   |   |         |
|                                           |   |                                                                               |   |   |   |       |   |   |   | Subtotal   |   |   |   | ***         |   | 35,672  |   | 0       |   |   |   | ***          |
| ***                                            |   |                                                                               |   |   |   |       |   |   |   |            |   |   |   |        |   |    |   |    |   |   |   |         |
| *** and Set up                                 |   |                                                                               |   | 1280   |   | 1.00       |   |   |   |            |   |   |   | 1,280       |   |    |   |    |   |   |   |         |
| Study Completion                               |   | *** and client correspondance                                                      |   | 501    |   | 1.00       |   |   |   |            |   |   |   | 501         |   |    |   |    |   |   |   |         |
| Study administration (first 8 months)          |   | Correspondence,  tracking, client, vision, filing                        |   | 160    |   | 6.00       |   |   |   |            |   |   |   | 960         |   |    |   |    |   |   |   |         |
| Prana Biotectnology Limited. *** (XXXX - XXXX) |   | Correspondence,  tracking, client vision, filling                        |   | 83     |   | 15.00      |   |   |   |            |   |   |   | 1,238       |   |    |   |    |   |   |   |         |

| INCR Project Code: 800089 | INC Research, LLC - CONFIDENTIAL | 1 |
|---------------------------|----------------------------------|---|

----

| ***                                                                                     |   | ***                                                                                                                                                                                                           |   | ***    |   | ***     |   | ***     |   | ***      |   | ***    |   | ***         |   | ***    |   | ***     |   | ***    |   | ***    |
|-----------------------------------------------------------------------------------------|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|--------|--------|---------|--------|---------|--------|----------|--------|--------|--------|-------------|--------|--------|--------|---------|--------|--------|--------|--------|
| Safety Administration                                                                   |   | Incl. set up, maintenance and completion activities                                                                                                                                                           |   | 3979   |   | 1.00    |   | 0.00    |   | 0.00     |   |   |   | 3,979       |   | 0      |   | 0       |   |   |   |   |
| Safaty Administration                                                                   |   | Study Extension                                                                                                                                                                                               |   | 83     |   | 0.00    |   | 14.00   |   | 0.00     |   |   |   | 0           |   | 1,155  |   | 0       |   |   |   |   |
| Initial Receipt and handing SAEs                                                        |   | All events - assume 1 SAE                                                                                                                                                                                     |   | 330    |   | 1.00    |   | 10.00   |   | 0.00     |   |   |   | 330         |   | 3,300  |   | 0       |   |   |   |   |
| Medical Review of SAEs and Narrative creation                                           |   | Optional as required                                                                                                                                                                                          |   | 838    |   | 0.00    |   | 10.00   |   | 0.00     |   |   |   | 0           |   | 8,380  |   | 0       |   |   |   |   |
| Reporting to local Authorities                                                          |   | Assume 1 Reportable events                                                                                                                                                                                    |   | 680    |   | 1.00    |   | 10.00   |   | 0.00     |   |   |   | 560         |   | 6,600  |   | 0       |   |   |   |   |
| Follow up of SAEs                                                                       |   | Assume 2 hours/Follow-up/SAE, 1 Follow ups.                                                                                                                                                                   |   | 330    |   | 1.00    |   | 10.00   |   | 0.00     |   |   |   | 330         |   | 3,300  |   | 0       |   |   |   |   |
| Investigator Notification Latters                                                       |   | properstion and oversight                                                                                                                                                                                     |   | 185    |   | 1.00    |   | 10.00   |   | 0.00     |   |   |   | 165         |   | 1,650  |   | 0       |   |   |   |   |
|                                                                                    |   |                                                                                                                                                                                                          |   |   |   |    |   |    |   | Subtotal |   |   |   | 5,464       |   | 24,385 |   | 0       |   |   |   | ***    |
| ***                                                                                     |   |                                                                                                                                                                                                          |   |   |   |    |   |    |   |     |   |   |   |        |   |   |   |    |   |   |   |   |
| CRF Design                                                                              |   | 25 unique pages. 60 pages of CRF and 11 pages of questionsite 91 Total pages One print run.                                                                                                              |   | 14,520 |   | 1.00    |   | 0.00    |   | 0.00     |   |   |   | 14,520      |   | 0      |   | 0       |   |   |   |   |
| CRF Design                                                                              |   | CRF design guidelines                                                                                                                                                                                         |   | 85     |   | 0.00    |   | 0.00    |   | 18.00    |   |   |   | 0           |   | 0      |   | 1,360   |   |   |   |   |
| CRF Design                                                                              |   | Edits and revisions for version 2                                                                                                                                                                             |   | 120    |   | 0.00    |   | 0.00    |   | 18.00    |   |   |   | 0           |   | 0      |   | 1,820   |   |   |   |   |
| CRF design update to version 2.0                                                        |   | Update to version 2                                                                                                                                                                                           |   | 120    |   |    |   |    |   |     |   | 4.00   |   |        |   |   |   |    |   | 480    |   |   |
| CRF Design (extension)                                                                  |   | 80 pages of CRF (70 on average entered ). One print run.                                                                                                                                                      |   | 2834   |   | 0.00    |   | 1.00    |   | 0.00     |   |   |   | 0           |   | 2,834  |   | 0       |   |   |   |   |
| Datebase design and build                                                               |   |                                                                                                                                                                                                          |   | 463    |   | 25.00   |   | 0.00    |   | 0.00     |   |   |   | 11,563      |   | 0      |   | 0       |   |   |   |   |
| Database design and build (extension)                                                   |   |                                                                                                                                                                                                          |   | 57     |   | 0.00    |   | 25.00   |   | 0.00     |   |   |   | 0           |   | 1,428  |   | 0       |   |   |   |   |
| Database update and testing per V2 of theCRFs        |   | Update to version 2                                                                                                                                                                                           |   | 120    |   |    |   |    |   |     |   | 4.00   |   |        |   |   |   |    |   | 480    |   |   |
| Edit Checks updete. end testing per V2 of the CRFs                                 |   | Update to version 3                                                                                                                                                                                           |   | 120    |   |    |   |    |   |     |   | 4.00   |   |        |   |   |   |    |   | 480    |   |   |
| Database/ Consistance Check programning                                                 |   |                                                                                                                                                                                                          |   | 53     |   | 208.25  |   | 0.00    |   | 0.00     |   |   |   | 11,114      |   | 0      |   | 0       |   |   |   |   |
| Database /Consistancy Check programming                                                 |   | Datebase and edit check programaning in support of version 2                                                                                                                                                  |   | 120    |   | 0.00    |   | 0.00    |   | 24.00    |   |   |   | 0           |   | 0      |   | 2,880   |   |   |   |   |
| Database / Consistancy Check programming (extension)                                    |   |                                                                                                                                                                                                          |   | 33     |   | 0.00    |   | 202.00  |   | 0.00     |   |   |   | 0           |   | 6,676  |   | 0       |   |   |   |   |
| Data Validation Manual / Date Management Plan                                           |   |                                                                                                                                                                                                          |   | 3400   |   | 1.00    |   | 0.00    |   | 0.00     |   |   |   | 3,400       |   | 0      |   | 0       |   |   |   |   |
| Date Validation Manual/ Date Management                                                 |   |                                                                                                                                                                                                          |   | 1664   |   | 0.00    |   | 1.00    |   | 0.00     |   |   |   | 0           |   | 1,664  |   | 0  |   |   |   |   |
| Data entry                                                                              |   | Double Data Entry 40 patterns x 80 CRF pages plus 40 x 11 questionaires 3640 total pages. Cost per extra pages=5.87                                                                                           |   | 6      |   | 3640.00 |   | 0.00    |   | 294.00   |   |   |   | 21,385      |   | 0      |   | 1,727   |   |   |   |   |
| Data entry (extension)                                                                  |   | Double Data Entry 33 patients X TO entered CRF pages 231D total pages. Coat oar extra pages=$6.28                                                                                                             |   | 6      |   | 0.00    |   | 2310.00 |   | 0.00     |   |   |   | 0           |   | 14,453 |   | 0       |   |   |   |   |
| Medical Coding                                                                          |   | MedDRA - AE. WHO - Drug                                                                                                                                                                                       |   | 6      |   | 800.00  |   | 0.00    |   | 0.00     |   |   |   | 5,036       |   | 0      |   | 0       |   |   |   |   |
| Medical Coding (extension)                                                              |   | MedDRA - AE. WHO - Drug                                                                                                                                                                                       |   | 7      |   | 0.00    |   | 680.00  |   | 0.00     |   |   |   | 0           |   | 4,600  |   | 0       |   |   |   |   |
| Data Clearing /Monitoring                                                               |   | 3200. CRF pages. Cost per. extra pages=$5.10                    224 Queries. Cost per extra quaery=$42.50 |   | 29617  |   | 1.00    |   | 0.00    |   | 0.00     |   |   |   | 29.617      |   | 0      |   | 0       |   |   |   |   |
| Data Cleaning / Monitoring                                                              |   | Additional pages cleaned/montored                                                                                                                                                                             |   | 5.10   |   | 0.00    |   | 0.00    |   | 734.00   |   |   |   | 0           |   | 0      |   | 3,743   |   |   |   |   |
| Data Clearing / Monitoring                                                              |   | Additional queries raised                                                                                                                                                                                     |   | 42.50  |   | 0.00    |   | 0.00    |   | 846.00   |   |   |   | 0           |   | 0      |   | 27,455  |   |   |   |   |
| Data Clearing Monitoring (Externsion)                                                   |   | 2310 CRF pages. Cost per em page=$7.00                    182 Queries. Cost per extra query=$52.00        |   | 28270  |   | 0.00    |   | 1.00    |   | 0.00     |   |   |   | 0           |   | 26,270 |   | 0       |   |   |   |   |
| Quality Control                                                                         |   | 10% of all patiemts 100% of all critical data (15% critical / 85% non critical)                                                                                                                               |   | 2.95   |   | 811,40  |   | 0.00    |   | 0.00     |   |   |   | ***         |   | 0      |   | 0       |   |   |   |   |
| Quality Control                                                                         |   | Additional Safety Lab QC Programming                                                                                                                                                                          |   | 120    |   | 0.00    |   | 0.00    |   | 4.00     |   |   |   | 0           |   | 0      |   | 480     |   |   |   |   |
| Quality Control                                                                         |   | Additional Safety Lab QC(pages)                                                                                                                                                                               |   | 2.81   |   | 0.00    |   | 0.00    |   | 91.00    |   |   |   | 0           |   | 0      |   | 256     |   |   |   |   |
| Quality Control (extension)                                                             |   | 10% of all patients, 100% of all critical data (15% critical / 85% non critical)                                                                                                                              |   | 3.34   |   | 0.00    |   | 543,00  |   | 0.00     |   |   |   | 0           |   | 1,313  |   | 0       |   |   |   |   |
| Import laboratory data                                                                  |   | 1 central lab.                                                                                                                                                                                                |   | 3680   |   | 1.00    |   | 0.00    |   | 0.00     |   |   |   |  3,680 |   | 0      |   | 0       |   |   |   |   |
| ***                                                                                     |   | 2 biomarker labs - programming                                                                                                                                                                                |   | 120    |   | 0.00    |   | 0.00    |   | ***      |   |   |   | 0      |   | 0      |   | 720     |   |   |   |   |
| ***                                                                                     |   | 2 biomarker labs - data review                                                                                                                                                                                |   | 85     |   | 0.00    |   | 0.00    |   | ***      |   |   |   |  0     |   | 0      |   | 910     |   |   |   |   |

| INCR Project Code: 800089 | INC Research, LLC - CONFIDENTIAL | 2 |
|---------------------------|----------------------------------|---|

----

| ***                                             |   | ***                                                                                                                                         |   | ***    |   | ***    |   | ***               |   | ***      |   | ***    |   | ***                       |   | ***                 |   | ***             |   | ***    |   | ***      |
|-------------------------------------------------|--------|---------------------------------------------------------------------------------------------------------------------------------------------|--------|--------|--------|--------|--------|-------------------|--------|----------|--------|--------|--------|---------------------------|--------|---------------------|--------|-----------------|--------|--------|--------|----------|
| Import laboratory data (extension)              |   | 1 central lab.       Import and review.                                                                  |   | 3182   |   | 0.00   |   | 1.00              |   | 0.00     |   |   |   | 0                         |   | 3,182               |   | 0          |   |   |   |     |
| Data exports                                    |   | Assume 2 exports                                                                                                                            |   | 360    |   | 2.00   |   | 0.00              |   | 0.00     |   |   |   | 720                       |   | 0                   |   | 0               |   |   |   |     |
| Data exports (extension)                        |   | Assume 2 exports                                                                                                                            |   | 327    |   | 0.00   |   | 2.00              |   | 0.00     |   |   |   | 0                         |   | 854                 |   | 0               |   |   |   |     |
| Database maintenance                            |   | Study Duration = 18 months                                                                                                             |   | 240    |   | 18.00  |   | 0.00              |   | 0.00     |   |   |   | 4,320                     |   | 0    |   | 0               |   |   |   |     |
| Database maintenance (extension)           |   | Study Duration = 18 months                                                                                                             |   | 218    |   | 0.00   |   | 18.00             |   | 0.00     |   |   |   | 0                         |   | 3,934               |   | 0               |   |   |   |     |
| DM & Statistics - Project Management        |   | Client meetings & corresp. DM metrics, 1hrs/month x 18 months                                                                           |   | 120    |   | 18.00  |   | 0.00              |   | 0.00     |   |   |   | 1,530                     |   | 0                   |   | 0               |   |   |   |     |
| DM & Statistics - Project Management   |   | Client meetings & corresp. DM metrics, 1hrs/month x 18 months                                                                           |   | 104    |   | 0.00   |   | 18.00             |   | 0.00     |   |   |   | 0                         |   | 1,872               |   | 0               |   |   |   |     |
| Input to protocol                               |   | Text and sample size calcualtion / power                                                                                                    |   | 200    |   | 4.00   |   | 0.00              |   | 0.00     |   |   |   | 800                       |   | 0                   |   | 0               |   |   |   |     |
| Generation of Randomisation schedule            |   | extra envelope $12.50                                                                                                                       |   | 1175   |   | 1.00   |   | 0.00              |   | 0.00     |   |   |   | 1,175                     |   | 0                   |   | 0               |   |   |   |     |
| Statistical Analysis Plan                       |   | Includes text and tables and listing shells                                                                                                 |   | 5840   |   | 1.00   |   | 0.00              |   | 0.00     |   |   |   | 5,840                     |   | 0                   |   | 0               |   |   |   |     |
| Statistical Analysis Plan                       |   | Additional hours to cover expansion of analysis. Includes discussion, editing, additional text additional tables and listing shells.        |   | 200    |   | 0.00   |   | 0.00              |   | 116.00   |   |   |   | 0                         |   | 0                   |   | 23,200          |   |   |   |     |
| Statistical Analysis Plan                       |   | Adaption of SAP for entension and comoined analysis. Includes text plus table & listing shells                                          |   | 6072   |   | 0.00   |   | 1.00              |   | 0.00     |   |   |   | 0                         |   | 6,072               |   | 0               |   |   |   |     |
| Analysis populations                            |   | Definition of populations                                                                                                                   |   | 1600   |   | 1.00   |   | 0.00              |   | 0.00     |   |   |   | 1,600                     |   | 0                   |   | 0               |   |   |   |     |
| (extension) Analysis populations                |   | Populations                                                                                                                                 |   | 1600   |   | 0.00   |   | 1.00              |   | 0.00     |   |   |   | 0                         |   | 1,600               |   | 0               |   |   |   |     |
| Analysis ***                                    |   | Specification, Programming & QC                                                                                                         |   | 4800   |   | 1.00   |   | 0.00              |   | 0.00     |   |   |   | 4,800                     |   | 0                   |   | 0               |   |   |   |     |
| Analysis ***                                    |   | Additional analysis *** to support increased analysis                                                                                  |   | 600    |   | 0.00   |   | 0.00              |   | 14.00    |   |   |   | 0                         |   | 0                   |   | 8,400           |   |   |   |     |
| Analysis *** (extension)                   |   | Specification, Programming & QC                                                                                                         |   | 3936   |   | 0.00   |   | 1.00              |   | 0.00     |   |   |   | 0                         |   | 3,936               |   | 0               |   |   |   |     |
| Production of Tables & Listings             |   | 15 Unique tables, Cost per extra $720 20 Repeat tables. Cost per extra $240 0 Figures. Cost per extra $420 35 Listings. Cost per extra $300 |   | 26100  |   | 1.00   |   | 0.00              |   | 0.00     |   |   |   | 26,100                    |   | 0                   |   | 0               |   |   |   |     |
| Production of Tables & Listings        |   | 22 Unique tables. Cost per extra $720 70 Report tables. Cost per extra $240 0 Figures. Cost per extra $420 40 Listings. Cost per extra $300 |   | 44640  |   | 0.00   |   | 0.00              |   | 1.00     |   |   |   | 0                         |   | 0                   |   | 44,640          |   |   |   |     |
| Production of Tables & Listings (extension) |   | 2 Uniques tables. Cost per extra $720 68 Repeat tables. Cost per extra $240 0 Figures. Cost per extra $420 35 Listings. Cost per extra $300 |   | 38622  |   | 0.00   |   | 1.00              |   | 0.00     |   |   |   | 0                         |   | 38,622              |   | 0               |   |   |   |     |
| Statistical Analysis                            |   | 10 analysis endpoints. Cost per extra $400                                                                                                  |   | 400    |   | 10.00  |   | 0.00              |   | 190.00   |   |   |   | 4,000                     |   | 0                   |   | 76,000          |   |   |   |     |
| Statistical Analysis (extension)                |   | 10 analysis endpoints. Cost per extra $424                                                                                                  |   | 424    |   | 0.00   |   | 10.00             |   | 0.00     |   |   |   | 0                         |   | 4,240               |   | 0               |   |   |   |     |
| Provision of *** to DSMB              |   | Assumes interim running and QC of 6 TFLs In row Programming Tables and ***.                                                                 |   | 960    |   | 3.00   |   | 0.00              |   | 0.00     |   |   |   | 2,880                     |   | 0                   |   | 0               |   |   |   |     |
| Provision of *** to DSMB (extension)       |   | Assumes provisional excel spredsheets and graphed laboratory values                                                                         |   | 1312   |   | 0.00   |   | 3.00              |   | 0.00     |   |   |   | 0                         |   | 3,936               |   | 0               |   |   |   |     |
| Input to Final report                           |   | Text for inclusion in study report                                                                                                          |   | 2400   |   | 1.00   |   | 0.00              |   | 0.00     |   |   |   | 2,400                     |   | 0                   |   | 0               |   |   |   |     |
| Input to Final report (extension)               |   | Text for inclusion in study report                                                                                                          |   | 2544   |   | 0.00   |   | 1.00              |   | 0.00     |   |   |   | 0                         |   | 2,544               |   | 0               |   |   |   |     |
|                                            |   |                                                                                                                                        |   |   |   |   |   |              |   | Subtotal |   |   |   | 158,369                   |   | 130,321             |   | 193,291         |   | ***    |   | $483,822 |
| Medical/Writing/(Optional)                      |   |                                                                                                                                        |   |   |   |   |   |              |   |     |   |   |   |                      |   |                |   |            |   |   |   |     |
| Clinical study report (CSR)                |   |                                                                                                                                        |   | 22497  |   | 1.00   |   | 1.00              |   | 0.00     |   |   |   | 22,497                    |   | 22,497              |   | 0               |   |   |   |     |
| QA review of CSR                                |   | Optional for Client                                                                                                                         |   | 2769   |   | 1.00   |   | 0.00              |   | 0.00     |   |   |   | 2,769                     |   | 0                   |   | 0               |   |   |   |     |
|                                            |   |                                                                                                                                        |   |   |   |   |   |              |   | Subtotal |   |   |   |    25,288  |   |   22,497       |   | 0               |   |   |   | $47,763  |
|                                            |   |                                                                                                                                        |   |   |   |   |   |              |   |     |   |   |   |                      |   |                |   |            |   |   |   |     |
|                                            |   |                                                                                                                                        |   |   |   |   |   |   TOTAL |   |     |   | ***    |   | ***                       |   | 183,231             |   |  ***  |   | ***    |

| Prana Biotechnology LimitedProtocol #: PBT2-204INCR Project Code: 800089 | INC Research, LLC - CONFIDENTIAL | 3 |
|--------------------------------------------------------------------------|----------------------------------|---|

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| ***                                                                                   |   | ***                                                  |   | ***        |   | ***    |   | ***         |   | ***    |   | ***    |   | ***    |   | ***    |   | ***     |   | ***     |
|---------------------------------------------------------------------------------------|--------|------------------------------------------------------|--------|------------|--------|--------|--------|-------------|--------|--------|--------|--------|--------|--------|--------|--------|--------|---------|--------|---------|
| Site Visits                                                                           |   |                                                 |   |       |   |   |   |        |   |   |   |   |   |   |   |   |   |    |   |    |
| Other Site visit Costs                                                                |   | Pariding/tolls/meals and incidentals for site visits |   | $50/day    |   | 60.00  |   | 50.00  |   | 3,000  |   | 2,500  |   | 0      |   | 0      |   |    |   |    |
|                                                                                  |   |                                                 |   |       |   |   |   | Subtotal    |   | 3,000  |   | ***    |   | 0      |   | 0      |   | $5,500  |   | $5,610  |
| General Expenses                                                                 |   |                                                 |   |       |   |   |   |        |   |   |   |   |   |   |   |   |   |    |   |    |
|                                                                                  |   |                                                 |   |       |   |   |   |        |   |   |   |   |   |   |   |   |   |    |   |    |
| General Expenses - Couriers, Postage, Telecommunications, Copying; stationary (files) |   | $70/site/month, 3 sites for 25 months                |   | $210/month |   | 25     |   | 0.00        |   | 5,250  |   | 0      |   | 0      |   | 0      |   |    |   |    |
|                                                                                  |   |                                                 |   |       |   |   |   |        |   |   |   |   |   |   |   |   |   |    |   |    |
| General Expenses - Couriers, Postage, Telecommunications, Copying, stationery (files) |   | $70/site/month, 2new sites for 16 months             |   | $140/month |   | 16     |   | 0.00        |   | 2,240  |   | 0      |   | 0      |   | 0      |   |    |   |    |
|                                                                                  |   |                                                 |   |       |   |   |   |        |   |   |   |   |   |   |   |   |   |    |   |    |
| General Expenses - Couriers, Postage, Telecommunications, Copying, stationery (files) |   | $70/site/month, 4 sites for 14 months                |   | $280/month |   | 0      |   | 14.00       |   | 0      |   | 3,920  |   | 0      |   | 0      |   |    |   |    |
| CRF Printing                                                                          |   |                                                 |   | $2,500     |   | 1      |   | 1.00        |   | 2,500  |   | 2,000  |   | 0      |   | 0      |   |    |   |    |
|                                                                                  |   |                                                 |   |       |   |   |   | Subtotal    |   | ***    |   | ***    |   | 0      |   | 0      |   | $15,919 |   | $16,228 |
|                                                                                  |   |                                                 |   |       |   |   |   |        |   |   |   |   |   |   |   |   |   |    |   |    |
|                                                                                  |   |                                                 |   |       |   |   |   | TOTAL       |   | 12,990 |   | 5,420  |   | 0      |   | 0      |   | $21,410 |   | $21,833 |

| Prana Biotechnology LimitedProtocol #: PBT2-204INCR Project Code: 800089 | INC Research, LLC - CONFIDENTIAL | 1 |
|--------------------------------------------------------------------------|----------------------------------|---|

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