Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 1 of 19 UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460

OFFICE OF PREVENTION, PESTICIDES

AND TOXIC SUBSTANCES



### MEMORANDUM

Date: 21-Jan-2010

Subject: Difenoconazole. Acute and Chronic Aggregate Dietary Exposure and Risk Assessments for the Section 3 Registration Request for Mango and Wax Apple.

PC Code: 128847 DP Barcode: 371613 Decision No.: 413927 Registration No.: None Petition Nos.: 9E7573 Regulatory Action: Section 3 Assessment Type: Single Chemical, Di etary Registration Case No.: NA
TXR No.: None CAS No.: 119446-68-3
MRID No.: None 40 CFR: 180.475



### Reviewer: Thurston G. Morton, Chemist
Risk Assessment Branch IV/Health Effects Division (RABIV/HED; 7509P)

Through: Doug Dotson, PhD., Chemist Julie Van Alstine, MPH, Environmental Health Scientist Dietary Exposure Science Advisory Council (DESAC)

And

Susan V. Hummel, Senior Chemist RABIV/HED (7509P)

To: Yan Donovan, Risk Assessor RABIV/HED (7509P)

And

Tony Kish Fungicide Branch/RD (7505P)

Executive SummaryDifenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 2 of 19 Aggregate (food + water) acute and chronic dietary risk assessments were conducted using the Dietary Exposure Evaluation Model - Food Consumption Intake Database (DEEM-FCID TM , ver. 2.03). This model uses food consumption data from the United States Department of Agriculture’s (USDA’s) Continuing Surveys of Food Intakes by Individuals (CSFII; 1994-1996 and 1998). The analyses were performed to support a Section 3 request for new uses of the fungicide difenoconazole [1-[2-[2-chloro-4 -(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2- ylmethyl]-1 H -1,2,4-triazole] in/on mango and wax apple.

The unrefined acute analysis assumed tolerance-level residues, 100% crop treated (CT), and the available empirical or DEEM TM (ver. 7.81) default processing factors. The resulting acute foodexposure estimates were less than HED’s level of concern (<100% of the acute populationadjusted dose (aPAD)) at the 95 th 

### percentile of the exposure distribution for the general U.S. population (7 % aPAD) and all population sub- groups; the most highly exposed population subgroup was children1-2 years old with 16 % aPAD. The somewhat refined chronic analysis assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, the available empirical or DEEM TM (ver. 7.81) default processing factors, and 100 % CT. The resulting chronic food exposure estimates were less than HED’s level of concern (<100% of the chronic population-adjusted dose (cPAD)) for the general U.S. population (17 % cPAD) and all population sub- groups; the most highly exposed population subgroup was children 1-2 years old with 45 % cPAD.

The requested uses of difenoconazole did not result in an increase in dietary exposure estimates for free triazole or conjugated triazoles. Therefore, the last dietary exposure analyses for the triazole metabolites (M. Negussie, 28 Oct. 2009) have not changed

.

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the PAD. The PAD is equivalent to the point of departure (POD, NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one
in one million. References which discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf ; or see SOP 99.6 (20-AUG-1999).

The most recent dietary risk assessment for difenoconazole was conducted by T. Morton (22- September-2009; DP#367383).

II. Residue InformationDifenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 3 of 19 Difenoconazole tolerances are published in 40 CFR§180.475.

Residues of Concern in Plants and Livestock: The HED Metabolism Assessment Review Committee (MARC) has determined that for tolerance expression and risk assessment purposes,
the residue of concern is difenoconazole per se for plant and livestock commodities. The MARC, however, stated that if tolerances are proposed for difenoconazole resulting from foliar uses which result in higher residue levels of CGA-205375 than parent, then the need to include CGA-205375 should be reconsidered (Memo, G. Kr amer, 22-JUL-1994; No DP#). Because the petitioner has now proposed foliar uses of difenoconazole, which result in higher residues in crop commodities, the need to include metabolite CGA 205375 in the tolerance expression and/or risk assessment has been re-examined. Based upon a review of the previously-submitted metabolism data for difenoconazole, HED concludes the residue of concern for both tolerance setting and risk assessment for the crops included in this petition is difenoconazole. However, HED concludes the residue of concern in livestock for tolerance setting and risk assessment are difenoconazole and its metabolite CGA 205375 (for more details, see the summary document, DP# 340379). Table 1 below summarizes tolerance expression and the residues of concern in plant and livestock commodities.

Table 1. Difenoconazole Residues of Concern in Plants and Ruminants.

Matrix Residues of Concern

For Risk Assessment For Tolerance Expression
Plants Primary and Rotational crops Parent Only Parent Only
Livestock Ruminant and Poultry Parent and CGA 205375 Parent and CGA 205375

Drinking Water Parent Only NA



### Recommended Tolerances: Based on the residue chemistry data submitted with the current petitions, HED recommended for establishment of the new food tolerances (DP# 366507, B. Cropp-Kohlligian, 21-Jan-2010). The recommended, established, and revised tolerances are
listed in Table 2 below.

Table 2. Tolerance Summary for Difenoconazole.Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 4 of 19

Commodity Existing/Established Tolerances (ppm) New Recommended Tolerances (ppm)

Almond, nutmeat 1 0.05 0.03 tree nut
Almond, hulls 1 5.0 7.0 Brassica subgroup 5A none 1.9 Brassica subgroup 5B none 35 Citrus, dried pulp none 2.5

Citrus oil none 25 Fruit, citrus, group 10 none 0.6
Grape 0.1 4.0 Grape, raisin none 6.0
Nut, tree, group 14 none 0.03 Onion, bulb, subgroup 3—07A none 0.20 Onion, green, subgroup 3—07B none 6.0

Pistachios none 0.03 Vegetable, cucurbit, group 9 1 1.0 individual RACs 0.7 Fruit, Pome, group 11 1.0
------ Vegetable, Fruiting, Group 8 0.60 ------ Vegetable, Tuberous and Corm, subgroup 1C 0.01 ------

Beet, sugar 2 0.30 ------
Papaya 0.30 ------ Apple, wet pomace 4.5 ------ Beet, sugar, dried pulp 1.9 ------ Potato, processed waste 0.04 ------

Banana 0.2 ------ Barley, grain 0.1 ------ Barley, hay 0.05 ------ Barley, straw 0.05 ------
Canola, seed 0.01 ------

Cattle fat 0.10 ------
Cattle, meat 0.05 ------ Cattle, meat byproducts 0.10 ------
Cattle, liver 0.20 ------ Corn, sweet, forage 0.01 ------ Corn, sweet, kernel plus cob
with husks removed 0.01 ------

Corn, sweet, stover 0.01 ------ Cotton, gin byproducts 0.05 ------
Cotton, undelinted seed 0.05 ------
Egg 3 0.10 ------
Goat, fat 0.10 ------
Goat, meat 0.05 ------ Goat, meat byproducts (except liver) 0.10 ------Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 5 of 19

Table 2. Tolerance Summary for Difenoconazole. Commodity Existing/Established Tolerances (ppm) New Recommended Tolerances (ppm)

Goat, liver 0.20 ------ Hog, fat 0.10 ------
Hog, meat 0.05 ------ Hog, meat byproducts (except liver) 0.1 ------

Hog, liver 0.20 ------
Horse, fat 0.10 ------
Horse, meat 0.05 ------ Horse, meat byproducts (except liver) 0.10 ------

Horse, liver 0.20 ------

Milk 0.01 ------ Rye, grain 0.1 ------ Sheep, fat 0.10 ------ Sheep, meat 0.05 ------ Sheep, meat byproducts (except liver) 0.10 ------

Sheep, liver 0.20 ------ Wheat, forage 0.1 ------ Wheat, grain 0.1 ------
Wheat, straw 0.1 ------ Wax apple None 0.07
Mango None 0.07

1 Section 18 emergency exemption tolerance.

2 The registered tolerance on sugar beet (0.01 ppm) needs to be changed to 0.3 ppm; see “Notes to RD” in memorandum: M. Sahafeya n, D351715, 07-MAY-08.

3 Based on a feeding study, HED recommended th e tolerances for poultry comm odities (except egg) be removed and the egg tolerance be increased to the current level of 0.1 ppm.



### The requested uses of difenoconazole did not result in an increase in dietary exposure estimates for free triazole or conjugated triazoles. Therefore, the last dietary exposure analyses for the triazole metabolites (M. Negussie, 28 Oct. 2009) have not changed

.

Food Residues and processing factors used in the Acute and Chronic Analysis: The acute analysis assumed tolerance-level residues and 100% CT for all the registered and proposed crops. Tolerance-level residues were also assumed for all livestock tissues in this assessment. The chronic analysis assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, and 100 % CT. Those commodities where field trial
data were used are summarized below. HED SOP 2000.1 Guidance for Translation of Field Trial Data from Representative Commodities in the Crop Group Regulation to Other Commodities in Each Crop Group/Subgroup dated 9/12/2000 was used in translating to other commodities in the crop group. Experimental processing factors were used for apple juice (0.04x), grape juice (0.2x), citrus juices (0.1x), potato chips (0.5x), potato granules/flakes (0.5x), raisin (3.5x chronic only), sugar beet molasses (0.6x), tomato paste (1.6x), and tomato pureeDifenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 6 of 19 (0.5x); DEEM TM (ver. 7.81) default processing factors were assumed for other processed
commodities.

No free triazole or conjugated triazole residue data were submitted with the mango residue field trial submission. However, current dietary exposure estimates are conservative enough that submission of this residue data on mango is not expected to result in an increase in aggregate exposure.

Almond: Field trial residues were used from MRID 47586101.

Apple: Field trial residues were used from MRID 46950233.

Broccoli: Field trial residues were used from MRID 47586102. Residues from 1-7 day PHI were used since registered labels allow from 1-7 day PHIs.

Cabbage: Field trial residues were used from 47586102. Residues from 1-7 day PHI were used since registered labels allow from 1-7 day PHIs. To refine the dietary exposure data from only cabbage samples without wrapper leaves were used.

Cantaloupe: Field trial residues were used from MRID 47586103. Residues from 0-1 day PHI were used since registered labels allow from 0-1 day PHI.

Cucumber: Field trial residues were used from MRID 47586103. Residues from 0-1 day PHI were used since registered labels allow from 0-1 day PHI.

Grape: Field trial residues were used from MRID 47586105.

Grapefruit: Field trial residues were used from MRID 47586104.

Leaf Lettuce: Field trial residues were used from MRIDs 47417703 and 47417706.

Lemon: Field trial residues were used from MRID 47586104.

Lime: Field trial residues were used from MRID 47586104.

Mustard Greens: Field trial residues were used from MRIDs 47417704, 47417707, and 47586102. Residues from 1-7 day PHI were used si nce registered labels allow from 1-7 day
PHIs.

Orange: Field trial residues were used from MRID 47586104.

Pear: Field trial residues were used from MRID 46950233.

Pecan: Field trial residues were used from MRID 47586106.

Peppers: Field trial residues were used from MRID 46950234.Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 7 of 19 Potato: Field trial residues were used from MRID 46950235.

Sugar Beet: Field trial residues were used from MRID 46950236.

Summer Squash: Field trial residues were used from MRID 47586103. Residues from 0-1 day PHI were used since registered labels allow from 0-1 day PHIs.

Tomato: Field trial residues were used from MRIDs 46950234, 47417705, and 47417708.

III. Drinking Water Data

The drinking water estimates used in the dietary risk assessment were provided by the Environmental Fate and Effects Division (E FED; Memo, I. Maher, 28-MAY-2009; D361398). EFED conducted a Tier II drinking water assessment for surface water sources using the Pesticide Root Zone/Exposure Analysis Modeling System (PRZM/EXAMS) for the registered and proposed new uses. Among all the registered and proposed new uses, the highest estimated drinking water concentrations (EDWCs) for surface water sources were derived for aerial applications of difenoconazole to New York grap es at the maximum annual application rate of 0.46 lb ai/acre. The estimated drinking water resi dues for 1-in-10 year annual peak, 1-in-10 year annual mean, and 36-year annual mean are 15.8, 10.4, and 7.62 μ g/L (ppb) respectively.

The highest SCI-GROW estimated drinking water c oncentration of difenoconazole from shallow ground water sources is 1.23 x 10 -2 

### μg/L derived for the maximum proposed application rate to citrus fruit (0.50 lb ai/A), i.e. agricultural uses. Based on the previous drinking water assessment, this estimate is lower than an estimate for non-agricultural uses of 1.28 x 10 -2 

### μg/L, obtained for the maximum application rate for ornamentals (0.52 lb ai/A; D333319). These concentrations can be considered as both the acute and chronic groundwater values.

The 1-in-10 year annual peak EDWC of 15.8 μ g/L (ppb) was used for the acute dietary exposure analysis and the 1-in-10 year annual mean EDWC of 10.4 μ g/L (ppb) was used for the chronic dietary exposure analysis.

IV. DEEM-FCID TM Program and Consumption Information

Difenoconazole acute and chronic dietary exposure assessments were conducted using the
DEEM-FCID TM (ver. 2.03), which incorporates consumption data from USDA’s CSFII (1994- 1996 and 1998). The 1994-96, 98 data are based on the reported consumption of more than 20,000 individuals over two non-consecutive survey days. Foods “as consumed” ( e.g. , apple pie) are linked to EPA-defined food commodities ( e.g. , apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups, but for acute exposure assessment are retained as individual consumption events. Based on analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns and survey respondents, HED concluded that it is most appropriate to report risk for theDifenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 8 of 19 following population subgroups: the general U.S. population, all infants (<1 year old), children 1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years
old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform ( e.g. , orange or orange juice) on the food commodity residue list is multiplied by the average daily consumption estimate for that food/food form. The resulting residue consumption estimate for each food/food form is summed with the residue consumption estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

For acute exposure assessments, individual one-day food consumption data are used on an individual-by-individual basis. The reported consumption amounts of each food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or “matched” in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the aPAD on both a user ( i.e. , those who reported eating relevant commodities/food forms) and a per-capita ( i.e. , those who reported eating the relevant commodities as well as those who did not) basis. In accordance with HED policy, per capita exposure and risk are reported for all tiers of analysis. However, for Tiers 1 and 2, significant differences in user vs. per capita exposure and risk are identified and noted in the risk

assessment.

V. Toxicological Information

On 08-SEP-1998, HED’s Hazard Identificati on Assessment Review Committee (HIARC) evaluated the toxicology database of difenoconazole and re-assessed the RfD established in 1994, as well as the toxicological endpoints for the dietary and occupational exposure risk assessments that were selected in 1994. At this meeting, the HIARC also addressed the potential enhanced sensitivity of infants and children from exposure to difenoconazole as required by the Food Quality Protection Act (FQPA) of 1996 (HED Doc. No. 012873, 25-SEP-1998). In July, 2007, the RAB1 toxicologists and risk assessment team met to reevaluate the endpoints selected by the HIARC since new studies were submitted. RAB1 toxicologists and risk assessment team also reevaluated FQPA assessments. The risk assessment team concluded that the default 10x FQPA Safety Factor (SF) should be reduced to 1x when assessing acute and chronic dietary exposures (M.Sahafeyan, D333320, 09-AUG-07). The relevant endpoints are shown in Table 3.

For purposes of this action, HED recently revi ewed HED’s 27-JUL-1994 Cancer Peer Review Committee (CPRC) report (Memo, Jess Rowland and Esther Rinde) on difenoconazole and the supporting data-evaluation records (DERs). HED c oncluded that difenoconazole is a very weak carcinogen, showing effects only at excessive dos es. In retrospect, the CPRC should have classified this pesticide as a category C with no linear quantification of cancer risk. The cRfD, based on borderline liver effects in male rats at 24.1 mg/kg and a NOAEL of 0.96 mg/kg, is protective of any carcinogenic effects seen in the mouse (Memo, S. Levy et al. , 05-AUG-2005;Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 9 of 19 DP# 319944). Therefore, a separate cancer dietary assessment is not being conducted for
difenoconazole.

Table 3. Summary of Toxicological Doses and Endpo ints for Difenoconazole for Use in Dietary Risk
Assessments.

Exposure
Scenario Point of Departure Uncertainty/FQPA Safety Factors RfD, PAD, for Risk
Assessment Study and Relevant Toxicological Effects Acute Dietary (All populations) NOAEL =
25 mg/kg UF A = 10X
UF H = 10X FQPA SF = 1X aRfD = aPAD = 0.25 mg/kg/day Acute Neurotoxicity Study
in Rats LOAEL= 200 mg/kg in
males based on reduced fore-limb grip strength in males on day 1.
Chronic Dietary (All populations) NOAEL =
0.96 mg/kg/day UF A = 10X
UF H = 10X FQPA SF = 1X cRfD = cPAD = 0.01mg/kg/day Combined chronic toxicity/carcinogenicity (rat; dietary) LOAEL = 24.1/32.8 mg/kg/day (M/F)
based on cumulative decreases in body-weight gains. Cancer (oral, dermal, inhalation) Difenoconazole is classified as a Group C, possible human carcinogen with a non-linear (MOE) approach for human risk characterization (CP RC Document, 7/27/94, Memo, P. V. Shah dated March 3, 2007, HED Doc. No. 0054532). The chronic dietary exposure assessment is protective of
cancer effects. Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. L OAEL = lowest observed adverse effect level. UF = uncertainty factor. UF A = extrapolation from animal to human (interspecies). UF H = potential variation in sensitivity among members of the human population (intrasp ecies). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic). RfD = reference dose.



### VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the aPAD or cPAD, respectively. The following paragraphs are summaries of the
DEEM-FCID TM (ver. 2.03) acute and chronic exposure analyses.

Acute and chronic aggregate (food + water) analyses were performed using DEEM-FCID TM estimating the dietary exposure of the U.S. population and various population subgroups. The results are summarized in Tables 4 and 5 below for acute and chronic analyses respectively.

The resulting acute food exposure estimates were less than HED’s level of concern (<100% aPAD) at the 95 th 

### percentile of the exposure distribution for general US population (7 % aPAD) and all population sub-groups; the most highly exposed population subgroup was Children 1-2 years old with 16 % aPAD. The resulting chronic food exposure estimates were less than HED’s level of concern (<100% cPAD) for the general U.S. population (17 % cPAD) and all population sub-groups; the most highly exposed population subgroup was children 1-2 years old with 45 % cPAD. A cancer dietary assessment was not conducted for difenoconazole because the cancer NOAEL is higher than the chronic RfD; therefore, the chronic dietary risk estimate is more protective.Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 10 of 19

Table 4. Summary of Acute Dietary Exposu re and Risk for Difenoconazole at the 95 th Percentile.

Population Subgroup aPAD (mg/kg/day) Exposure (mg/kg/day) %aPAD

General U.S. Population

0.25 0.017747 7

All Infants (< 1 year old) 0.0255139 10

Children 1-2 years old 0.039565 16

Children 3-5 years old 0.031818 13

Children 6-12 years old 0.017949 7

Youth 13-19 years old 0.008828 4

Adults 20-49 years old 0.013083 5

Adults 50+ years old 0.017255 7

Females 13-49 years old 0.013281 5

The bolded %aPAD is the highest.

Table 5. Summary of Chronic Dietary Exposure and Risk for Difenoconazole.

Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) %cPAD

General U.S. Population

0.01 0.001709 17

All Infants (< 1 year old) 0.002445 25

Children 1-2 years old 0.004484 45

Children 3-5 years old 0.003624 36

Children 6-12 years old 0.002061 21

Youth 13-19 years old 0.001372 14

Adults 20-49 years old 0.001376 14

Adults 50+ years old 0.001548 16

Females 13-49 years old 0.001402 14

The bolded %cPAD is the highest.



### VII. Characterization of Inputs/Outputs

The acute analysis assumed tolerance-level residues, 100% CT, and empirical or DEEM TM default processing factors. The chronic analysis assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, 100 % CT, and empirical or DEEM TM default processing factors. Therefore, these analyses are considered conservative. They do not warrant the need for further refinement at this time.Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 11 of 19 VIII. Conclusions

An acute aggregate (food + water) dietary risk assessment was conducted for difenoconazole using the DEEM-FCID TM (ver. 2.03) Model and assumed tolerance-level residues, 100% CT, and empirical or DEEM TM default processing factors. The chronic aggregate dietary risk assessment assumed tolerance-level residues for some commodities, average field trial residues for the majority of commodities, 100 % CT, and empirical or DEEM TM default processing factors. The resulting acute and chronic aggregate exposure estimates were less than HED’s level of concern. For the general U.S. population, the aPAD and cPAD were 7 % and 17 %, respectively. The most highly-exposed population subgroups in the acute (at the 95 th 

### percentile of the exposure distribution) and chronic analyses were Child ren 1-2 years old (16 % aPAD) and children 1-2 years old (45 % cPAD), respectively.

IX. Attachments

Attachment 1: DEEM-FCID TM Acute Residue File
Attachment 2: DEEM-FCID TM Acute Exposure Estimates
Attachment 3: DEEM-FCID TM Chronic Residue File
Attachment 4: DEEM-FCID TM Chronic Exposure Estimates

cc with all attachments: T. Morton (RABIV) RDI: D. Dotson and J.Van Alstine - DESAC (7-Jan-2010); S. Hummel (21-Jan-2010) Petition Number(s): PP#8F7482
DP#: 371613
PC Code: 128847 T. Morton:S10922:PY1:(703)305-6691Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 12 of 19 Attachment 1: DEEM-FCID TM Acute Residue File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 DifenocozoleNew Uses of Wax Apple and Mango\difenoconazole_acute-01-10.R98
Chemical: Difenoconazole RfD(Chronic): .01 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 01-12-2010/10:30:55/8 Program ver. 2.03

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 95000230 O Banana 0.200000 1.000 1.000 95000231 O Banana-babyfood 0.200000 1.000 1.000 95000240 O Banana, dried 0.200000 3.900 1.000 95000241 O Banana, dried-babyfood 0.200000 3.900 1.000 95001280 O Cottonseed, oil 0.050000 1.000 1.000 95001281 O Cottonseed, oil-babyfood 0.050000 1.000 1.000 95001750 O Grape 4.000000 1.000 1.000 95001760 O Grape, juice 4.000000 0.200 1.000 95001761 O Grape, juice-babyfood 4.000000 0.200 1.000 95001770 O Grape, leaves 4.000000 1.000 1.000 95001780 O Grape, raisin 6.000000 1.000 1.000 95001790 O Grape, wine and sherry 4.000000 1.000 1.000 95002150 O Mango 0.070000 1.000 1.000 95002151 O Mango-babyfood 0.070000 1.000 1.000 95002160 O Mango, dried 0.070000 1.000 1.000 95002170 O Mango, juice 0.070000 1.000 1.000 95002171 O Mango, juice-babyfood 0.070000 1.000 1.000 95002450 O Papaya 0.300000 1.000 1.000 95002451 O Papaya-babyfood 0.300000 1.000 1.000 95002460 O Papaya, dried 0.300000 1.800 1.000 95002470 O Papaya, juice 0.300000 1.500 1.000 95002830 O Plantain 0.200000 1.000 1.000 95002840 O Plantain, dried 0.200000 3.900 1.000 86010000 O Water, direct, all sources 0.015800 1.000 1.000 86020000 O Water, indirect, all sources 0.015800 1.000 1.000 21000440 M Beef, meat 0.050000 1.000 1.000 21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 21000450 M Beef, meat, dried 0.050000 1.920 1.000 21000460 M Beef, meat byproducts 0.100000 1.000 1.000 21000461 M Beef, meat byproducts-babyfood 0.100000 1.000 1.000 21000470 M Beef, fat 0.100000 1.000 1.000 21000471 M Beef,fat-babyfood 0.100000 1.000 1.000 21000480 M Beef, kidney 0.100000 1.000 1.000 21000490 M Beef, liver 0.200000 1.000 1.000 21000491 M Beef, liver-babyfood 0.200000 1.000 1.000 23001690 M Goat, meat 0.050000 1.000 1.000 23001700 M Goat, meat byproducts 0.100000 1.000 1.000 23001710 M Goat, fat 0.100000 1.000 1.000 23001720 M Goat, kidney 0.100000 1.000 1.000 23001730 M Goat, liver 0.200000 1.000 1.000 24001890 M Horse, meat 0.050000 1.000 1.000 25002900 M Pork, meat 0.050000 1.000 1.000 25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 25002910 M Pork, skin 0.100000 1.000 1.000 25002920 M Pork, meat byproducts 0.100000 1.000 1.000 25002921 M Pork, meat byproducts-babyfood 0.100000 1.000 1.000 25002930 M Pork, fat 0.100000 1.000 1.000 25002931 M Pork, fat-babyfood 0.100000 1.000 1.000 25002940 M Pork, kidney 0.100000 1.000 1.000 25002950 M Pork, liver 0.200000 1.000 1.000 26003390 M Sheep, meat 0.050000 1.000 1.000 26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 26003400 M Sheep, meat byproducts 0.100000 1.000 1.000 26003410 M Sheep, fat 0.100000 1.000 1.000 26003411 M Sheep, fat-babyfood 0.100000 1.000 1.000 26003420 M Sheep, kidney 0.100000 1.000 1.000 26003430 M Sheep, liver 0.200000 1.000 1.000 70001450 P Egg, whole 0.100000 1.000 1.000 70001451 P Egg, whole-babyfood 0.100000 1.000 1.000 70001460 P Egg, white 0.100000 1.000 1.000 70001461 P Egg, white (solids)-babyfood 0.100000 1.000 1.000 70001470 P Egg, yolk 0.100000 1.000 1.000 70001471 P Egg, yolk-babyfood 0.100000 1.000 1.000Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 13 of 19 27002220 D Milk, fat 0.010000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.010000 1.000 1.000 27012230 D Milk, nonfat solids 0.010000 1.000 1.000 27012231 D Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 27022240 D Milk, water 0.010000 1.000 1.000 27022241 D Milk, water-babyfood/infant form 0.010000 1.000 1.000 27032251 D Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 01010520 1A Beet, sugar 0.300000 1.000 1.000 01010521 1A Beet, sugar-babyfood 0.300000 1.000 1.000 01010530 1A Beet, sugar, molasses 0.300000 0.600 1.000 01010531 1A Beet, sugar, molasses-babyfood 0.300000 0.600 1.000 01032960 1C Potato, chips 0.010000 0.500 1.000 01032970 1C Potato, dry (granules/ flakes) 0.010000 0.500 1.000 01032971 1C Potato, dry (granules/ flakes)-b 0.010000 0.500 1.000 01032980 1C Potato, flour 0.010000 0.500 1.000 01032981 1C Potato, flour-babyfood 0.010000 0.500 1.000 01032990 1C Potato, tuber, w/peel 0.010000 1.000 1.000 01032991 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 01033001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 1.000 03001640 3 Garlic 0.200000 1.000 1.000 03001650 3 Garlic, dried 0.200000 1.000 1.000 03001651 3 Garlic, dried-babyfood 0.200000 1.000 1.000
03001980 3 Leek 6.000000 1.000 1.000 03002370 3 Onion, dry bulb 0.200000 1.000 1.000 03002371 3 Onion, dry bulb-babyfood 0.200000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 03002381 3 Onion, dry bulb, dried-babyfood 0.200000 9.000 1.000 03002390 3 Onion, green 6.000000 1.000 1.000
03003380 3 Shallot 0.200000 1.000 1.000 05010610 5A Broccoli 1.900000 1.000 1.000 05010611 5A Broccoli-babyfood 1.900000 1.000 1.000 05010620 5A Broccoli, Chinese 1.900000 1.000 1.000 05020630 5B Broccoli raab 35.000000 1.000 1.000 05010640 5A Brussels sprouts 1.900000 1.000 1.000 05010690 5A Cabbage 1.900000 1.000 1.000 05020700 5B Cabbage, Chinese, bok choy 35.000000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 1.900000 1.000 1.000 05010720 5A Cabbage, Chinese, mustard 1.900000 1.000 1.000 05010830 5A Cauliflower 1.900000 1.000 1.000
05021170 5B Collards 35.000000 1.000 1.000
05021940 5B Kale 35.000000 1.000 1.000 05011960 5A Kohlrabi 1.900000 1.000 1.000 05022290 5B Mustard greens 35.000000 1.000 1.000 05023180 5B Rape greens 35.000000 1.000 1.000 05023890 5B Turnip, greens 35.000000 1.000 1.000 08001480 8 Eggplant 0.600000 1.000 1.000
08002340 8 Okra 0.600000 1.000 1.000 08002700 8 Pepper, bell 0.600000 1.000 1.000 08002701 8 Pepper, bell-babyfood 0.600000 1.000 1.000 08002710 8 Pepper, bell, dried 0.600000 1.000 1.000 08002711 8 Pepper, bell, dried-babyfood 0.600000 1.000 1.000 08002720 8 Pepper, nonbell 0.600000 1.000 1.000 08002721 8 Pepper, nonbell-babyfood 0.600000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.600000 1.000 1.000 08003740 8 Tomatillo 0.600000 1.000 1.000
08003750 8 Tomato 0.600000 1.000 1.000 08003751 8 Tomato-babyfood 0.600000 1.000 1.000 08003760 8 Tomato, paste 0.600000 1.600 1.000 08003761 8 Tomato, paste-babyfood 0.600000 1.600 1.000 08003770 8 Tomato, puree 0.600000 0.500 1.000 08003771 8 Tomato, puree-babyfood 0.600000 0.500 1.000 08003780 8 Tomato, dried 0.600000 14.300 1.000 08003781 8 Tomato, dried-babyfood 0.600000 14.300 1.000 08003790 8 Tomato, juice 0.600000 1.500 1.000 09020210 9B Balsam pear 0.700000 1.000 1.000 09010750 9A Cantaloupe 0.700000 1.000 1.000
09010800 9A Casaba 0.700000 1.000 1.000 09020880 9B Chayote, fruit 0.700000 1.000 1.000 09021020 9B Chinese waxgourd 0.700000 1.000 1.000
09021350 9B Cucumber 0.700000 1.000 1.000 09011870 9A Honeydew melon 0.700000 1.000 1.000 09023080 9B Pumpkin 0.700000 1.000 1.000 09023090 9B Pumpkin, seed 0.700000 1.000 1.000 09023560 9B Squash, summer 0.700000 1.000 1.000 09023561 9B Squash, summer-babyfood 0.700000 1.000 1.000Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 14 of 19 09023570 9B Squash, winter 0.700000 1.000 1.000 09023571 9B Squash, winter-babyfood 0.700000 1.000 1.000
09013990 9A Watermelon 0.700000 1.000 1.000 09014000 9A Watermelon, juice 0.700000 1.000 1.000 10001060 10 Citrus citron 0.600000 1.000 1.000 10001070 10 Citrus hybrids 0.600000 1.000 1.000 10001080 10 Citrus, oil 25.000000 1.000 1.000 10001800 10 Grapefruit 0.600000 1.000 1.000 10001810 10 Grapefruit, juice 0.600000 0.100 1.000 10001970 10 Kumquat 0.600000 1.000 1.000
10001990 10 Lemon 0.600000 1.000 1.000 10002000 10 Lemon, juice 0.600000 0.100 1.000 10002001 10 Lemon, juice-babyfood 0.600000 0.100 1.000 10002010 10 Lemon, peel 0.600000 1.000 1.000 10002060 10 Lime 0.600000 1.000 1.000 10002070 10 Lime, juice 0.600000 0.100 1.000 10002071 10 Lime, juice-babyfood 0.600000 0.100 1.000 10002400 10 Orange 0.600000 1.000 1.000 10002410 10 Orange, juice 0.600000 0.100 1.000 10002411 10 Orange, juice-babyfood 0.600000 0.100 1.000 10002420 10 Orange, peel 0.600000 1.000 1.000
10003070 10 Pummelo 0.600000 1.000 1.000 10003690 10 Tangerine 0.600000 1.000 1.000 10003700 10 Tangerine, juice 0.600000 0.100 1.000 11000070 11 Apple, fruit with peel 1.000000 1.000 1.000 11000080 11 Apple, peeled fruit 1.000000 1.000 1.000 11000081 11 Apple, peeled fruit-babyfood 1.000000 1.000 1.000 11000090 11 Apple, dried 1.000000 8.000 1.000 11000091 11 Apple, dried-babyfood 1.000000 8.000 1.000 11000100 11 Apple, juice 1.000000 0.040 1.000 11000101 11 Apple, juice-babyfood 1.000000 0.040 1.000 11000110 11 Apple, sauce 1.000000 1.000 1.000 11000111 11 Apple, sauce-babyfood 1.000000 1.000 1.000 11001290 11 Crabapple 1.000000 1.000 1.000 11002100 11 Loquat 1.000000 1.000 1.000
11002660 11 Pear 1.000000 1.000 1.000 11002661 11 Pear-babyfood 1.000000 1.000 1.000 11002670 11 Pear, dried 1.000000 6.250 1.000 11002680 11 Pear, juice 1.000000 1.000 1.000 11002681 11 Pear, juice-babyfood 1.000000 1.000 1.000 11003100 11 Quince 1.000000 1.000 1.000
14000030 14 Almond 0.030000 1.000 1.000 14000031 14 Almond-babyfood 0.030000 1.000 1.000 14000040 14 Almond, oil 0.030000 1.000 1.000 14000041 14 Almond, oil-babyfood 0.030000 1.000 1.000 14000590 14 Brazil nut 0.030000 1.000 1.000
14000680 14 Butternut 0.030000 1.000 1.000
14000810 14 Cashew 0.030000 1.000 1.000
14000920 14 Chestnut 0.030000 1.000 1.000 14001550 14 Filbert 0.030000 1.000 1.000 14001560 14 Filbert, oil 0.030000 1.000 1.000 14001850 14 Hickory nut 0.030000 1.000 1.000 14002130 14 Macadamia nut 0.030000 1.000 1.000
14002690 14 Pecan 0.030000 1.000 1.000 14002820 14 Pistachio 0.030000 1.000 1.000
14003910 14 Walnut 0.030000 1.000 1.000 15000250 15 Barley, pearled barley 0.100000 1.000 1.000 15000251 15 Barley, pearled barley-babyfood 0.100000 1.000 1.000 15000260 15 Barley, flour 0.100000 1.000 1.000 15000261 15 Barley, flour-babyfood 0.100000 1.000 1.000 15000270 15 Barley, bran 0.100000 1.000 1.000 15001270 15 Corn, sweet 0.010000 1.000 1.000 15001271 15 Corn, sweet-babyfood 0.010000 1.000 1.000 15003280 15 Rye, grain 0.100000 1.000 1.000 15003290 15 Rye, flour 0.100000 1.000 1.000 15004010 15 Wheat, grain 0.100000 1.000 1.000 15004011 15 Wheat, grain-babyfood 0.100000 1.000 1.000 15004020 15 Wheat, flour 0.100000 1.000 1.000 15004021 15 Wheat, flour-babyfood 0.100000 1.000 1.000 15004030 15 Wheat, germ 0.100000 1.000 1.000 15004040 15 Wheat, bran 0.100000 1.000 1.000Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 15 of 19 Attachment 2: DEEM-FCID TM Acute Exposure Estimates

U.S. Environmental Protection Agency Ver. 2.02 DEEM-FCID ACUTE Analysis for DIFENOCONAZOLE (1994-98 data) Residue file: difenoconazole_acute-01-10.R98 Adjustment factor #2 used. Analysis Date: 01-12-2010/14:29:03 Residue file dated: 01-12-2010/14:23:34/8 Daily totals for food and foodform consumption used.

Run Comment: ""

===============================================================================

Summary calculations (per capita):

95th Percentile 99th Percentile 99.9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD

---------- -------- ---------- -------- ---------- -------- U.S. Population:
0.017747 7.10 0.051415 20.57 0.142474 56.99 All infants:
0.025139 10.06 0.040570 16.23 0.118410 47.36 Children 1-2 yrs:
0.039565 15.83 0.087361 34.94 0.251716 100.69 Children 3-5 yrs:
0.031818 12.73 0.070329 28.13 0.373423 149.37 Children 6-12 yrs:
0.017949 7.18 0.038892 15.56 0.148702 59.48 Youth 13-19 yrs:
0.008828 3.53 0.039549 15.82 0.137882 55.15 Adults 20-49 yrs:
0.013083 5.23 0.041933 16.77 0.109522 43.81 Adults 50+ yrs:
0.017255 6.90 0.062629 25.05 0.138639 55.46 Females 13-49 yrs:
0.013281 5.31 0.042028 16.81 0.116292 46.52Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 16 of 19 Attachment 3: DEEM-FCID TM Chronic Residue File

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 DifenocozoleNew Uses of Wax Apple and Mango\difenoconazole_chronic-01-10AverageFT.R98
Chemical: Difenoconazole RfD(Chronic): .01 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 01-12-2010/10:31:20/8 Program ver. 2.03

-------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

-------- ---- ------------------------------- ---------- ------ ------ ------- 95000230 O Banana 0.200000 1.000 1.000 95000231 O Banana-babyfood 0.200000 1.000 1.000 95000240 O Banana, dried 0.200000 3.900 1.000 95000241 O Banana, dried-babyfood 0.200000 3.900 1.000 95001280 O Cottonseed, oil 0.050000 1.000 1.000 95001281 O Cottonseed, oil-babyfood 0.050000 1.000 1.000 95001750 O Grape 0.613000 1.000 1.000 95001760 O Grape, juice 0.613000 0.200 1.000 95001761 O Grape, juice-babyfood 0.613000 0.200 1.000 95001770 O Grape, leaves 0.613000 1.000 1.000 95001780 O Grape, raisin 0.613000 3.500 1.000 95001790 O Grape, wine and sherry 0.613000 1.000 1.000 95002150 O Mango 0.070000 1.000 1.000 95002151 O Mango-babyfood 0.070000 1.000 1.000 95002160 O Mango, dried 0.070000 1.000 1.000 95002170 O Mango, juice 0.070000 1.000 1.000 95002171 O Mango, juice-babyfood 0.070000 1.000 1.000 95002450 O Papaya 0.300000 1.000 1.000 95002451 O Papaya-babyfood 0.300000 1.000 1.000 95002460 O Papaya, dried 0.300000 1.800 1.000 95002470 O Papaya, juice 0.300000 1.500 1.000 95002830 O Plantain 0.200000 1.000 1.000 95002840 O Plantain, dried 0.200000 3.900 1.000 86010000 O Water, direct, all sources 0.010400 1.000 1.000 86020000 O Water, indirect, all sources 0.010400 1.000 1.000 21000440 M Beef, meat 0.050000 1.000 1.000 21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 21000450 M Beef, meat, dried 0.050000 1.920 1.000 21000460 M Beef, meat byproducts 0.100000 1.000 1.000 21000461 M Beef, meat byproducts-babyfood 0.100000 1.000 1.000 21000470 M Beef, fat 0.100000 1.000 1.000 21000471 M Beef,fat-babyfood 0.100000 1.000 1.000 21000480 M Beef, kidney 0.100000 1.000 1.000 21000490 M Beef, liver 0.200000 1.000 1.000 21000491 M Beef, liver-babyfood 0.200000 1.000 1.000 23001690 M Goat, meat 0.050000 1.000 1.000 23001700 M Goat, meat byproducts 0.100000 1.000 1.000 23001710 M Goat, fat 0.100000 1.000 1.000 23001720 M Goat, kidney 0.100000 1.000 1.000 23001730 M Goat, liver 0.200000 1.000 1.000 24001890 M Horse, meat 0.050000 1.000 1.000 25002900 M Pork, meat 0.050000 1.000 1.000 25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 25002910 M Pork, skin 0.100000 1.000 1.000 25002920 M Pork, meat byproducts 0.100000 1.000 1.000 25002921 M Pork, meat byproducts-babyfood 0.100000 1.000 1.000 25002930 M Pork, fat 0.100000 1.000 1.000 25002931 M Pork, fat-babyfood 0.100000 1.000 1.000 25002940 M Pork, kidney 0.100000 1.000 1.000 25002950 M Pork, liver 0.200000 1.000 1.000 26003390 M Sheep, meat 0.050000 1.000 1.000 26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 26003400 M Sheep, meat byproducts 0.100000 1.000 1.000 26003410 M Sheep, fat 0.100000 1.000 1.000 26003411 M Sheep, fat-babyfood 0.100000 1.000 1.000 26003420 M Sheep, kidney 0.100000 1.000 1.000 26003430 M Sheep, liver 0.200000 1.000 1.000 70001450 P Egg, whole 0.100000 1.000 1.000 70001451 P Egg, whole-babyfood 0.100000 1.000 1.000 70001460 P Egg, white 0.100000 1.000 1.000 70001461 P Egg, white (solids)-babyfood 0.100000 1.000 1.000 70001470 P Egg, yolk 0.100000 1.000 1.000 70001471 P Egg, yolk-babyfood 0.100000 1.000 1.000Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 17 of 19 27002220 D Milk, fat 0.010000 1.000 1.000 27002221 D Milk, fat - baby food/infant for 0.010000 1.000 1.000 27012230 D Milk, nonfat solids 0.010000 1.000 1.000 27012231 D Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 27022240 D Milk, water 0.010000 1.000 1.000 27022241 D Milk, water-babyfood/infant form 0.010000 1.000 1.000 27032251 D Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 01010520 1A Beet, sugar 0.300000 1.000 1.000 01010521 1A Beet, sugar-babyfood 0.300000 1.000 1.000 01010530 1A Beet, sugar, molasses 0.300000 0.600 1.000 01010531 1A Beet, sugar, molasses-babyfood 0.300000 0.600 1.000 01032960 1C Potato, chips 0.005000 0.500 1.000 01032970 1C Potato, dry (granules/ flakes) 0.005000 0.500 1.000 01032971 1C Potato, dry (granules/ flakes)-b 0.005000 0.500 1.000 01032980 1C Potato, flour 0.005000 0.500 1.000 01032981 1C Potato, flour-babyfood 0.005000 0.500 1.000 01032990 1C Potato, tuber, w/peel 0.005000 1.000 1.000 01032991 1C Potato, tuber, w/peel-babyfood 0.005000 1.000 1.000 01033000 1C Potato, tuber, w/o peel 0.005000 1.000 1.000 01033001 1C Potato, tuber, w/o peel-babyfood 0.005000 1.000 1.000 03001640 3 Garlic 0.200000 1.000 1.000 03001650 3 Garlic, dried 0.200000 1.000 1.000 03001651 3 Garlic, dried-babyfood 0.200000 1.000 1.000
03001980 3 Leek 6.000000 1.000 1.000 03002370 3 Onion, dry bulb 0.200000 1.000 1.000 03002371 3 Onion, dry bulb-babyfood 0.200000 1.000 1.000 03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 03002381 3 Onion, dry bulb, dried-babyfood 0.200000 9.000 1.000 03002390 3 Onion, green 6.000000 1.000 1.000
03003380 3 Shallot 0.200000 1.000 1.000 05010610 5A Broccoli 0.221000 1.000 1.000 05010611 5A Broccoli-babyfood 0.221000 1.000 1.000 05010620 5A Broccoli, Chinese 0.221000 1.000 1.000 05020630 5B Broccoli raab 5.100000 1.000 1.000 05010640 5A Brussels sprouts 29.000000 1.000 1.000 05010690 5A Cabbage 0.029000 1.000 1.000 05020700 5B Cabbage, Chinese, bok choy 5.100000 1.000 1.000 05010710 5A Cabbage, Chinese, napa 0.029000 1.000 1.000 05010720 5A Cabbage, Chinese, mustard 0.221000 1.000 1.000 05010830 5A Cauliflower 0.221000 1.000 1.000
05021170 5B Collards 5.100000 1.000 1.000
05021940 5B Kale 5.100000 1.000 1.000 05011960 5A Kohlrabi 0.029000 1.000 1.000 05022290 5B Mustard greens 5.100000 1.000 1.000 05023180 5B Rape greens 5.100000 1.000 1.000 05023890 5B Turnip, greens 5.100000 1.000 1.000 08001480 8 Eggplant 0.133000 1.000 1.000
08002340 8 Okra 0.600000 1.000 1.000 08002700 8 Pepper, bell 0.133000 1.000 1.000 08002701 8 Pepper, bell-babyfood 0.133000 1.000 1.000 08002710 8 Pepper, bell, dried 0.133000 1.000 1.000 08002711 8 Pepper, bell, dried-babyfood 0.133000 1.000 1.000 08002720 8 Pepper, nonbell 0.133000 1.000 1.000 08002721 8 Pepper, nonbell-babyfood 0.133000 1.000 1.000 08002730 8 Pepper, nonbell, dried 0.133000 1.000 1.000 08003740 8 Tomatillo 0.165000 1.000 1.000
08003750 8 Tomato 0.165000 1.000 1.000 08003751 8 Tomato-babyfood 0.165000 1.000 1.000 08003760 8 Tomato, paste 0.165000 1.600 1.000 08003761 8 Tomato, paste-babyfood 0.165000 1.600 1.000 08003770 8 Tomato, puree 0.165000 0.500 1.000 08003771 8 Tomato, puree-babyfood 0.165000 0.500 1.000 08003780 8 Tomato, dried 0.165000 14.300 1.000 08003781 8 Tomato, dried-babyfood 0.165000 14.300 1.000 08003790 8 Tomato, juice 0.165000 1.500 1.000 09020210 9B Balsam pear 0.055000 1.000 1.000 09010750 9A Cantaloupe 0.137000 1.000 1.000
09010800 9A Casaba 0.137000 1.000 1.000 09020880 9B Chayote, fruit 0.310000 1.000 1.000 09021020 9B Chinese waxgourd 0.055000 1.000 1.000
09021350 9B Cucumber 0.055000 1.000 1.000 09011870 9A Honeydew melon 0.137000 1.000 1.000 09023080 9B Pumpkin 0.031000 1.000 1.000 09023090 9B Pumpkin, seed 0.031000 1.000 1.000 09023560 9B Squash, summer 0.031000 1.000 1.000 09023561 9B Squash, summer-babyfood 0.031000 1.000 1.000Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 18 of 19 09023570 9B Squash, winter 0.031000 1.000 1.000 09023571 9B Squash, winter-babyfood 0.031000 1.000 1.000
09013990 9A Watermelon 0.137000 1.000 1.000 09014000 9A Watermelon, juice 0.137000 1.000 1.000 10001060 10 Citrus citron 0.208000 1.000 1.000 10001070 10 Citrus hybrids 0.208000 1.000 1.000 10001080 10 Citrus, oil 25.000000 1.000 1.000 10001800 10 Grapefruit 0.120000 1.000 1.000 10001810 10 Grapefruit, juice 0.120000 0.100 1.000 10001970 10 Kumquat 0.208000 1.000 1.000
10001990 10 Lemon 0.176000 1.000 1.000 10002000 10 Lemon, juice 0.176000 0.100 1.000 10002001 10 Lemon, juice-babyfood 0.176000 0.100 1.000 10002010 10 Lemon, peel 0.176000 1.000 1.000 10002060 10 Lime 0.176000 1.000 1.000 10002070 10 Lime, juice 0.176000 0.100 1.000 10002071 10 Lime, juice-babyfood 0.176000 0.100 1.000 10002400 10 Orange 0.208000 1.000 1.000 10002410 10 Orange, juice 0.208000 0.100 1.000 10002411 10 Orange, juice-babyfood 0.208000 0.100 1.000 10002420 10 Orange, peel 0.208000 1.000 1.000
10003070 10 Pummelo 0.120000 1.000 1.000 10003690 10 Tangerine 0.208000 1.000 1.000 10003700 10 Tangerine, juice 0.208000 0.100 1.000 11000070 11 Apple, fruit with peel 0.203000 1.000 1.000 11000080 11 Apple, peeled fruit 0.203000 1.000 1.000 11000081 11 Apple, peeled fruit-babyfood 0.203000 1.000 1.000 11000090 11 Apple, dried 0.203000 8.000 1.000 11000091 11 Apple, dried-babyfood 0.203000 8.000 1.000 11000100 11 Apple, juice 0.203000 0.040 1.000 11000101 11 Apple, juice-babyfood 0.203000 0.040 1.000 11000110 11 Apple, sauce 0.203000 1.000 1.000 11000111 11 Apple, sauce-babyfood 0.203000 1.000 1.000 11001290 11 Crabapple 0.203000 1.000 1.000 11002100 11 Loquat 0.123000 1.000 1.000
11002660 11 Pear 0.123000 1.000 1.000 11002661 11 Pear-babyfood 0.123000 1.000 1.000 11002670 11 Pear, dried 0.123000 6.250 1.000 11002680 11 Pear, juice 0.123000 1.000 1.000 11002681 11 Pear, juice-babyfood 0.123000 1.000 1.000 11003100 11 Quince 0.123000 1.000 1.000
14000030 14 Almond 0.005000 1.000 1.000 14000031 14 Almond-babyfood 0.005000 1.000 1.000 14000040 14 Almond, oil 0.005000 1.000 1.000 14000041 14 Almond, oil-babyfood 0.005000 1.000 1.000 14000590 14 Brazil nut 0.007000 1.000 1.000
14000680 14 Butternut 0.007000 1.000 1.000
14000810 14 Cashew 0.007000 1.000 1.000
14000920 14 Chestnut 0.005000 1.000 1.000 14001550 14 Filbert 0.007000 1.000 1.000 14001560 14 Filbert, oil 0.007000 1.000 1.000 14001850 14 Hickory nut 0.007000 1.000 1.000 14002130 14 Macadamia nut 0.007000 1.000 1.000
14002690 14 Pecan 0.007000 1.000 1.000 14002820 14 Pistachio 0.005000 1.000 1.000
14003910 14 Walnut 0.007000 1.000 1.000 15000250 15 Barley, pearled barley 0.100000 1.000 1.000 15000251 15 Barley, pearled barley-babyfood 0.100000 1.000 1.000 15000260 15 Barley, flour 0.100000 1.000 1.000 15000261 15 Barley, flour-babyfood 0.100000 1.000 1.000 15000270 15 Barley, bran 0.100000 1.000 1.000 15001270 15 Corn, sweet 0.010000 1.000 1.000 15001271 15 Corn, sweet-babyfood 0.010000 1.000 1.000 15003280 15 Rye, grain 0.100000 1.000 1.000 15003290 15 Rye, flour 0.100000 1.000 1.000 15004010 15 Wheat, grain 0.100000 1.000 1.000 15004011 15 Wheat, grain-babyfood 0.100000 1.000 1.000 15004020 15 Wheat, flour 0.100000 1.000 1.000 15004021 15 Wheat, flour-babyfood 0.100000 1.000 1.000 15004030 15 Wheat, germ 0.100000 1.000 1.000 15004040 15 Wheat, bran 0.100000 1.000 1.000Difenoconazole Dietary Exposure Assessment DP#: 371613
PC Code: 128847



### 19 of 19 Attachment 4: DEEM-FCID TM Chronic Exposure Estimates

U.S. Environmental Protection Agency Ver. 2.00 DEEM-FCID Chronic analysis for DIFENOCONAZOLE (1994-98 data) Residue file name: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 DifenocozoleNew Uses of Wax Apple and Mango\difenoconazole_chronic-01-10AverageFT.R98 Adjustment factor #2 used. Analysis Date 01-12-2010/14:26:21 Residue file dated: 01-12-2010/14:24:16/8 Reference dose (RfD, Chronic) = .01 mg/kg bw/day

=============================================================================== Total exposure by population subgroup

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Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --------------- U.S. Population (total) 0.001709 17.1%

U.S. Population (spring season) 0.001689 16.9% U.S. Population (summer season) 0.001761 17.6% U.S. Population (autumn season) 0.001678 16.8% U.S. Population (winter season) 0.001710 17.1%

Northeast region 0.001653 16.5% Midwest region 0.001671 16.7% Southern region 0.001610 16.1% Western region 0.001958 19.6%

Hispanics 0.001635 16.3% Non-hispanic whites 0.001626 16.3% Non-hispanic blacks 0.002000 20.0% Non-hisp/non-white/non-black 0.002426 24.3%

All infants (< 1 year) 0.002445 24.5% Nursing infants 0.001287 12.9% Non-nursing infants 0.002885 28.9% Children 1-6 yrs 0.003762 37.6% Children 7-12 yrs 0.001941 19.4%

Females 13-19 (not preg or nursing) 0.001233 12.3% Females 20+ (not preg or nursing) 0.001490 14.9% Females 13-50 yrs 0.001475 14.7% Females 13+ (preg/not nursing) 0.001295 13.0% Females 13+ (nursing) 0.001522 15.2%

Males 13-19 yrs 0.001506 15.1% Males 20+ yrs 0.001385 13.9% Seniors 55+ 0.001574 15.7%

Children 1-2 yrs 0.004484 44.8% Children 3-5 yrs 0.003624 36.2% Children 6-12 yrs 0.002061 20.6% Youth 13-19 yrs 0.001372 13.7% Adults 20-49 yrs 0.001376 13.8% Adults 50+ yrs 0.001548 15.5% Females 13-49 yrs 0.001402 14.0%

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