EX-10.4.3





 Exhibit 10.4.3 

NOTICE OF EXERCISE 
  

			
	 Biodesix, Inc.
 2970 Wilderness Place, Suite
100
 Boulder, CO 80301
	  	Date of Exercise:                         

 This constitutes notice to Biodesix, Inc. (the “Company”) under my stock option that I elect to
purchase the below number of shares of Common Stock of the Company (the “Shares”) for the price set forth below. 
  

					
	Type of option (check one):	  	Incentive ☐	  	Nonstatutory ☐
			
	Stock option dated:	  		  	
			
	 Number of Shares
 as to which option is

exercised:
	  		  	
			
	 Certificates to be
 issued in name of:
	  		  	
			
	Total exercise price:	  	$    	  	$    
			
	 Cash payment delivered
 herewith:
	  	$    	  	$    
			
	 Value of                    
Shares
 delivered herewith1:
	  	$    	  	$    
			
	 Value of                     

Shares pursuant to net exercise2:
	  	$    	  	$    
			
	 Regulation T Program (cashless
 exercise3):
	  	$    	  	$    

 By this exercise, I agree (i) to provide such additional documents as you may require pursuant to the terms of the 2016
Equity Incentive Plan, (ii) to provide for the payment by me to you (in the manner designated by you) of your withholding obligation, if any, relating to the exercise of this option, and (iii) if this exercise relates to an incentive stock
option, to notify you in writing within 15 days after the date of any disposition of any of the Shares issued upon exercise of this option that occurs within two years after the date of grant of this option or within one year after such Shares are
issued upon exercise of this option. 
  
  

	1 	 Shares must meet the public trading requirements set forth in the option. Shares must be valued in accordance
with the terms of the option being exercised, and must be owned free and clear of any liens, claims, encumbrances or security interests. Certificates must be endorsed or accompanied by an executed assignment separate from certificate.




	2 	 The option must be a Nonstatutory Stock Option, and Biodesix, Inc. must have established net exercise
procedures at the time of exercise, in order to utilize this payment method. 



	3 	 Shares must meet the public trading requirements set forth in the option. 














 I hereby make the following certifications and representations with respect to the number of Shares listed
above, which are being acquired by me for my own account upon exercise of the option as set forth above: 
 I acknowledge that the Shares have not been
registered under the Securities Act of 1933, as amended (the “Securities Act”), and are deemed to constitute “restricted securities” under Rule 701 and Rule 144 promulgated under the Securities Act. I warrant and
represent to the Company that I have no present intention of distributing or selling said Shares, except as permitted under the Securities Act and any applicable state securities laws. 

I further acknowledge that I will not be able to resell the Shares for at least 90 days after the stock of the Company becomes publicly traded (i.e.,
subject to the reporting requirements of Section 13 or 15(d) of the Securities Exchange Act of 1934) under Rule 701 and that more restrictive conditions apply to affiliates of the Company under Rule 144. 

I further acknowledge that all certificates representing any of the Shares subject to the provisions of the Option shall have endorsed thereon appropriate
legends reflecting the foregoing limitations, as well as any legends reflecting restrictions pursuant to the Company’s Articles of Incorporation, Bylaws and/or applicable securities laws. 

I further agree that, if required by the Company (or a representative of the underwriters) in connection with the first underwritten registration of the
offering of any securities of the Company under the Securities Act, I will not sell, dispose of, transfer, make any short sale of, grant any option for the purchase of, or enter into any hedging or similar transaction with the same economic effect
as a sale with respect to any shares of Common Stock or other securities of the Company for a period of 180 days following the effective date of a registration statement of the Company filed under the Securities Act (or such longer period as the
underwriters or the Company shall request to facilitate compliance with FINRA Rule 2711 or NYSE Member Rule 472 or any successor or similar rule or regulation) (the “Lock-Up Period”). I
further agree to execute and deliver such other agreements as may be reasonably requested by the Company or the underwriters that are consistent with the foregoing or that are necessary to give further effect thereto. In order to enforce the
foregoing covenant, the Company may impose stop-transfer instructions with respect to securities subject to the foregoing restrictions until the end of such period. 

 

	
	Very truly yours,
	
	   

	














 BIODESIX, INC. 

VOTING AGREEMENT 

Counterpart Signature Page 

Reference is hereby made to that certain Sixth Amended and Restated Voting Agreement, dated as of April 12, 2017, by and among Biodesix,
Inc. (the “Company”) and each of the parties listed on the signature pages thereto, as such agreement may be amended from time to time (the “Voting Agreement”). 

By execution of this Counterpart Signature Page to the Voting Agreement, the undersigned hereby: 

(a) acknowledges receipt of a copy of the Voting Agreement; and (b) agrees to become a party to, be bound by and obtain the benefit of the rights and
restrictions of the Voting Agreement as an “Investor” under the Voting Agreement. 
 IN WITNESS WHEREOF, the undersigned has
executed this Counterpart Signature Page as of the     day of                , 20    . 

 

	
	INVESTOR: