**EXHIBIT        4.14**

**AMENDMENT NO.** **2**

THIS        AGREEMENT made the 31st day of March, 2008.

BETWEEN:

ONCOLYTICS BIOTECH INC.

(“Oncolytics”)

 

- and        -

 

GEORGE        GILL, M.D.

(“Gill”)

WHEREAS Oncolytics and Gill entered into a Services Agreement dated the 18th        day of October, 2002, as amended by Amending Agreement No. 1 dated January 6,        2005 (the “Services Agreement)”

AND WHEREAS the parties wish to amend the Services Agreement;

NOW THEREFORE the parties agree as follows:

Section        1 – Amendments

The Services Agreement is hereby amended by revising the first paragraph of        Schedule B as follows;

“Commencing January 1, 2008, Oncolytics shall pay to Gill an        annual retainer of ONE HUNDRED MINE THOUSAND TWO HUNDRED AND SEVENTY-TWO UNITED STATES        DOLLARS AND SEVENTY CENTS (US$109,272.70) per annum, payable in equal monthly installments        of NINE THOUSAND ONE HUNDRED SIX UNITED STATES DOLLARS AND SIX CENTS (US$9,106.06) on the        last day of each month.”

Section        2 - Effective Date

| (1) | This Amending Agreement shall be effective from and after                    January 1, 2008. |
|-----|----------------------------------------------------------------------------------------------------|

(2)          In all other respects the parties confirm that the Services Agreement, as        amended, shall remain in full force and effect.

 

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IN WITNESS WHEREOF the parties have executed this Agreement as of the day        and year first above written.

**ONCOLYTICS BIOTECH INC.**

         

Per:     /s/ Brad        Thompson                                                  

|   | Brad Thompson       |   |
|--------|---------------------|--------|
|   | President & CEO |

         

         

Per:     /s/        Doug Ball                                                          

|   | Doug Ball               |   |
|--------|-------------------------|--------|
|   | Chief Financial Officer |

 

|                                                                                                |                                                                                                                                                                                                                                                                                                                                                                               |
|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| /s/ Karyn C.                    Gill                                                                                                                                                                                                                 | /s/ George                    Gill                                                         |
| WITNESS                                                                                                                                                                                                                                                                                                                                                                                                                                                                          |                                                                                                                                                                                                                                                                                                                                                                                    | GEORGE GILL, M.D. |

 

 

-2-

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