EX-10.1





 Exhibit 10.1 

SQZ Biotechnologies Company 

2014 Stock Incentive Plan 
  

	 	1.	 Purpose. 



The purpose of this plan (the “Plan”) is to secure for SQZ Biotechnologies Company., a Delaware corporation (the
“Company”) and its shareholders the benefits arising from capital stock ownership by employees, officers and directors of, and consultants or advisors to, the Company and its parent and subsidiary corporations who are
expected to contribute to the Company’s future growth and success. Under the Plan recipients may be awarded both (i) Options (as defined in Section 2.1) to purchase the Company’s common stock, par value $.001 (“Common
Stock”) and (ii) shares of Common Stock (“Restricted Stock Awards”). Except where the context otherwise requires, the term “Company” shall include any parent and all present and
future subsidiaries of the Company as defined in Sections 424(e) and 424(f) of the Internal Revenue Code of 1986, as amended or replaced from time to time (the “Code”). Those provisions of the Plan which make express
reference to Section 422 of the Code shall apply only to Incentive Stock Options (as that term is defined below). 
  

	 	2.	 Types of Awards and Administration. 



2.1 Options. Options granted pursuant to the Plan (“Options”) shall be authorized by action
of the Board of Directors of the Company (the “Board’’ or “Board of Directors”) and may be either incentive stock options (“Incentive Stock Options”) meeting the
requirements of Section 422 of the Code or non-statutory Options which are not intended to meet the requirements of Section 422. All Options when granted are intended to be non-statutory Options, unless the applicable Option Agreement (as defined in Section 5.1) explicitly states that the Option is intended to be an Incentive Stock Option. The vesting of Options may be conditioned
upon the completion of a specified period of employment with the Company and/or such other conditions or events as the Board may determine. The Board may also provide that Options are immediately exercisable subject to certain repurchase rights in
the Company dependent upon the continued employment of the optionee and/or such other conditions or events as the Board may determine. 

2.1.1 Incentive Stock Options. Incentive Stock Options may only be granted to employees of the Company. For so long as the Code
shall so provide, Options granted to any employee under the Plan (and any other incentive stock option plans of the Company) which are intended to constitute Incentive Stock Options shall not constitute Incentive Stock Options to the extent that
such Options, in the aggregate, become exercisable for the first time in any one calendar year for shares of Common Stock with an aggregate fair market value (determined as of the respective date or dates of grant) of more than $100,000. If an
Option is intended to be an Incentive Stock Option, and if for any reason such Option (or any portion thereof) shall not qualify as an Incentive Stock Option, then, to the extent of such nonqualification, such Option (or portion thereof) shall be
regarded as a non-statutory Option appropriately granted under the Plan provided that such Option (or portion thereof) otherwise meets the Plan’s requirements relating to non-statutory Options. 












 2.2 Restricted Stock Awards. The Board in its discretion may
grant Restricted Stock Awards, entitling the recipient to acquire, for a purchase price determined by the Board, shares of Common Stock subject to such restrictions and conditions as the Board may determine at the time of grant
(“Restricted Stock”), including continued employment and/or achievement of pre-established performance goals and objectives. 

2.3 Administration. The Plan shall be administered by the Board, whose construction and interpretation of the
terms and provisions of the Plan shall be final and conclusive. The Board may in its sole discretion authorize issuance of Restricted Stock, the grant of Options and the issuance of shares upon exercise of such Options as provided in the Plan. The
Board shall have authority, subject to the express provisions of the Plan, to construe Restricted Stock Agreements, Option Agreements and the Plan, to prescribe, amend and rescind rules and regulations relating to the Plan, to determine the terms
and provisions of Restricted Stock Agreements and Option Agreements, and to make all other determinations in the judgment of the Board necessary or desirable for the administration of the Plan. The Board may correct any defect or supply any omission
or reconcile any inconsistency in the Plan or in any Restricted Stock Agreement or Option Agreement in the manner and to the extent it shall deem expedient to carry the Plan into effect and it shall be the sole and final judge of such expediency. No
director or person acting pursuant to authority delegated by the Board shall be liable for any action or determination under the Plan made in good faith. The Board may, to the full extent permitted by or consistent with applicable laws or
regulations, delegate any or all of its powers under the Plan to a committee (the “Committee”) appointed by the Board, and if the Committee is so appointed, to the extent of such delegation, all references to the Board in the
Plan shall mean and relate to such Committee, other than references to the Board in this sentence and in Section 18 (as to amendment or termination of the Plan) and Section 22. 

 

	 	3.	 Eligibility. 



Options may be granted, and Restricted Stock may be issued, to persons who are, at the time of such grant or issuance, employees, officers or
directors of, or consultants or advisors to, the Company; provided that the class of persons to whom Incentive Stock Options may be granted shall be limited to employees of the Company.  

3.1 10% Shareholder. If any employee to whom an Incentive Stock Option is to be granted is, at the time of the
grant of such Option, the owner of stock possessing more than 10% of the total combined voting power of all classes of stock of the Company (after taking into account the attribution of stock ownership rules of Section 424(d) of the Code) (a
“Greater Than 10% Shareholder”), any Incentive Stock Option granted to such individual must: (i) have an exercise price per share of not less than 110% of the fair market value of one share of Common Stock at the time of
grant; and (ii) expire by its terms not more than five years from the date of grant. 

  
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	 	4.	 Stock Subject to Plan. 



Subject to adjustment as provided in Section 14.2 below, the maximum number of shares of Common Stock which may be issued under the Plan
is 3,859,080 shares, all of which may be issued with respect to Incentive Stock Options. If an Option shall expire or terminate for any reason without having been exercised in full, the unpurchased shares subject to such Option shall again be
available for subsequent Option grants or Restricted Stock Awards under the Plan. If shares of Restricted Stock shall be forfeited to, or otherwise repurchased by, the Company pursuant to a Restricted Stock Agreement, such repurchased shares shall
again be available for subsequent Option grants or Restricted Stock Awards under the Plan. If shares issued upon exercise of an Option are tendered to the Company in payment of the exercise price of an Option, such tendered shares shall again be
available for subsequent Option grants or Restricted Stock Awards under the Plan. 
  

	 	5.	 Forms of Restricted Stock Agreements and Option Agreements. 



5.1 Option Agreement. Each recipient of an Option shall execute an option agreement (“Option Agreement”)
in such form not inconsistent with the Plan as may be approved by the Board of Directors. Such Option Agreements may differ among recipients. 

5.2 Restricted Stock Agreement. Each recipient of a grant of Restricted Stock shall execute an agreement (“Restricted Stock
Agreement”) in such form not inconsistent with the Plan as may be approved by the Board of Directors. Such Restricted Stock Agreements may differ among recipients. 

5.3 “Lock-Up” Agreement. Unless the Board specifies otherwise,
each Restricted Stock Agreement and Option Agreement shall provide that upon the request of the Company or the managing underwriter(s) of any offering of securities of the Company that is the subject of a registration statement filed under the
United States Securities Act of 1933, as amended from time to time (the “Act”), the holder of any Option or the purchaser of any Restricted Stock shall, in connection therewith, agree in writing (in such form as the Company
or such managing underwriter(s) shall request) to the general effect that for a period of time (not to exceed 180 days, plus such additional number of days (not to exceed 35) as may reasonably be requested to enable the underwriter(s) of such
offering to comply with Rule 2711(f) of the Financial Industry Regulatory Authority or any amendment or successor thereto) from the effective date of the registration statement under the Act for such offering, the holder or purchaser will not sell,
make any short sale of, loan, grant any option for the purchase of, or otherwise dispose of any shares of the common stock of the Company owned or controlled by him or her. 
  

	 	6.	 Purchase Price. 



6.1 General. The purchase price per share of Restricted Stock and per share of stock deliverable upon the exercise of an Option
shall be determined by the Board, provided, however, that in the case of any Option, the exercise price shall not be less than 100% of the fair market value of such stock, as determined by the Board, at the time of grant of such Option, or less than
110% of such fair market value in the case of any Incentive Stock Option granted to a Greater Than 10% Shareholder. 

  
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 6.2 Payment of Purchase Price. Option Agreements may provide for the payment
of the exercise price by delivery of cash or a check to the order of the Company in an amount equal to the exercise price of such Options, or, to the extent provided in the applicable Option Agreement, by one of the following methods: 

                (i) with the consent of the
Board, by delivery to the Company of shares of Common Stock; such surrendered shares shall have a fair market value equal in amount to the exercise price of the Options being exercised, 

                (ii) with the consent of the
Board, a personal recourse note issued by the optionee to the Company in a principal amount equal to such aggregate exercise price and with such other terms, including interest rate and maturity, as the Company may determine in its discretion;
provided, however, that the interest rate borne by such note shall not be less than the lowest applicable federal rate, as defined in Section 1274(d) of the Code, 

                (iii) with the consent of the
Board, if the class of Common Stock is registered under the Securities Exchange Act of 1934 at such time, subject to rules as may be established by the Board, by delivery to the Company of a properly executed exercise notice along with irrevocable
instructions to a broker to promptly deliver to the Company cash or a check payable and acceptable to the Company for the purchase price, 

                (iv) with the consent of the
Board, by reducing the number of Option shares otherwise issuable to the optionee upon exercise of the Option by a number of shares of Common Stock having a fair market value equal to such aggregate exercise price, 

                (v) with the consent of the
Board, by any combination of such methods of payment. 
 The fair market value of any shares of Common Stock or other non-cash consideration which may be delivered upon exercise of an Option shall be determined by the Board of Directors. Restricted Stock Agreements may provide for the payment of any purchase price in any manner
approved by the Board of Directors at the time of authorizing the issuance thereof. 
  

	 	7.	 Option Period. 



Notwithstanding any other provision of the Plan or any Option Agreement, each Option and all rights thereunder shall expire on the date
specified in the applicable Option Agreement, provided that such date shall not be later than ten years after the date on which the Option is granted (or five years in the case of an Incentive Stock Option granted to a Greater Than 10% Shareholder),
and in either case, shall be subject to earlier termination as provided in the Plan or Option Agreement. 
  

	 	8.	 Exercise of Options. 



8.1 General. Each Option shall be exercisable either in full or in installments at such time or times and during such period as
shall be set forth in the Option Agreement evidencing such Option, subject to the provisions of the Plan. To the extent not exercised, installments shall accumulate and be exercisable, in whole or in part, at any time after becoming exercisable, but
not later than the date the Option expires. 

  
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 8.2 Notice of Exercise. An Option may be exercised by the optionee by
delivering to the Company on any business day a written notice specifying the number of shares of Common Stock the optionee then desires to purchase and specifying the address to which the certificates for such shares are to be mailed (the
“Notice”), accompanied by payment for such shares. In addition, the Company may require any individual to whom an Option is granted, as a condition of exercising such Option, to give written assurances (the
“Investment Letter”) in a substance and form satisfactory to the Company to the effect that such individual is acquiring the Common Stock subject to the Option for his or her own account for investment and not with a view to
the resale or distribution thereof, and to such other effects as the Company deems necessary or advisable in order to comply with any securities law(s). 

8.3 Delivery. As promptly as practicable after receipt of the Notice, the Investment Letter (if required) and payment, the
Company shall deliver or cause to be delivered to the optionee certificates for the number of shares with respect to which such Option has been so exercised, issued in the optionee’s name; provided, however, that such delivery shall be deemed
effected for all purposes when the Company or a stock transfer agent shall have deposited such certificates in the United States mail, addressed to the optionee, at the address specified in the Notice. 

 

	 	9.	 Transferability of Options. 



No Incentive Stock Option shall be assignable or transferable by the person to whom it is granted, either voluntarily or by operation of law,
except by will or the laws of descent and distribution, and during the life of an optionee, an Incentive Stock Option shall be exercisable only by the optionee. The Board may, in its discretion, determine the extent to which a non-statutory Option shall be transferable 
 9. Termination of Employment; Disability;
Death. Except as may be otherwise expressly provided in the terms and conditions of the Option Agreement, Options shall terminate on the earliest to occur of: 
  

	 	(i)	 the date of expiration thereof; 



 

	 	(ii)	 90 days after termination of the optionee’s employment with, or provision of services to, the Company by
the Company for Cause (as hereinafter defined); 


  

	 	(iii)	 90 days after the date of voluntary termination of the optionee’s employment with, or provision of
services to, the Company by the optionee (other than for death or permanent disability as defined below); or 


  

	 	(iv)	 90 days after the date of termination of the optionee’s employment with, or provision of services to, the
Company by the Company without Cause (other than for death or permanent disability as defined below). 



  
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 Until the date on which the Option so expires, the optionee may exercise that portion of his or her Option
which is exercisable at the time of termination of the employment or service relationship. 
 An employment or service relationship between
the Company and the optionee shall be deemed to exist during any period during which the optionee is employed by or providing services to the Company. Whether an authorized leave of absence or an absence due to military or government service shall
constitute termination of the employment relationship between the Company and the optionee shall be determined by the Board at the time thereof. 

For purposes of this Section 10, the term “Cause” shall mean (a) any material breach by the
optionee of any agreement to which the optionee and the Company are both parties, (b) any act (other than retirement) or omission to act by the optionee which may have a material and adverse effect on the Company’s business or on the
optionee’s ability to perform services for the Company, including, without limitation, the commission of any crime (other than minor traffic violations), or (c) any material misconduct or material neglect of duties by the optionee in
connection with the business or affairs of the Company. An optionee’s employment shall be deemed to have been terminated for Cause if the Company determines within thirty (30) days of the termination of employment (whether such termination
was voluntary or involuntary) that termination for Cause was warranted. 
 In the event of the permanent and total disability or death of an
optionee while in an employment or other relationship with the Company, any Option held by such optionee shall terminate on the earlier of the date of expiration of the Option or 180 days following the date of such disability or death. After
disability or death, the optionee (or in the case of death, his or her executor, administrator or any person or persons to whom this option may be transferred by will or by laws of descent and distribution) shall have the right, at any time prior to
such termination of an Option , to exercise the Option to the extent the optionee was entitled to exercise such Option as of the date of his or her disability or death. An optionee is permanently and totally disabled if he or she is unable to engage
in any substantial gainful activity by reason of any medically determinable physical or mental impairment which can be expected to last for a continuous period of not less than 12 months; permanent and total disability shall be determined in
accordance with Section 22(e)(3) of the Code and the regulations issued thereunder. 
 10. Rights as a
Shareholder. The holder of an Option shall have no rights as a shareholder with respect to any shares covered by the Option (including, without limitation, any rights to receive dividends or
non-cash distributions with respect to such shares) until the date of issue of a stock certificate to him or her for such shares. No adjustment shall be made for dividends or other rights for which the record
date is prior to the date such stock certificate is issued. 
 11. Additional Provisions. The Board of
Directors may, in its sole discretion, include additional provisions in Restricted Stock Agreements and Option Agreements, including, without limitation, restrictions on transfer, rights of the Company to repurchase shares of Restricted Stock or
shares of Common Stock acquired upon exercise of Options, commitments to pay cash bonuses, to make, arrange for or guaranty loans or to transfer other property to optionees upon exercise of Options, or such other provisions as shall be determined by
the Board of Directors; provided that such additional provisions shall not be inconsistent with any other term or condition of the Plan and such additional provisions shall not be such as to cause any Incentive Stock Option to fail to qualify
as an Incentive Stock Option within the meaning of Section 422 of the Code. 

  
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 12. Acceleration, Extension, Etc. The Board of Directors may, in its
sole discretion, (i) accelerate the date or dates on which all or any particular Option or Options may be exercised or (ii) extend the period or periods oftime during which all, or any particular, Option or Options may be exercised. 

13. Adjustment Upon Changes in Capitalization 

13.1 No Effect of Options upon Certain Corporate Transactions. The existence of outstanding Options shall not affect in any way
the right or power of the Company to make or authorize any or all adjustments, recapitalizations, reorganizations or other changes in the Company’s capital structure or its business, or any merger or consolidation, or any issue of Common Stock,
or any issue of bonds, debentures, preferred or prior preference stock ahead of or affecting the Common Stock or the rights thereof, or the dissolution or liquidation of the Company, or any sale or transfer of all or any part of its assets or
business, or any other corporate act or proceeding, whether of a similar character or otherwise. 
 13.2 Adjustment
Provisions. If, through or as a result of any merger, consolidation, sale of all or substantially all of the assets of the Company, reorganization, recapitalization, reclassification, stock dividend, stock split, reverse stock split or other
similar transaction, (i) the outstanding shares of Common Stock are increased, decreased or exchanged for a different number or kind of shares or other securities of the Company, or (ii) additional shares or new or different shares or
other securities of the Company or other non-cash assets are distributed with respect to such shares of Common Stock or other securities, an appropriate and proportionate adjustment shall be made in
(x) the maximum number and kind of shares reserved for issuance under the Plan, (y) the number and kind of shares or other securities subject to any then outstanding Options, and (z) the price for each share or other security subject
to any then outstanding Options, so that upon exercise of such Options, in lieu of the shares of Common Stock for which such Options were then exercisable, the relevant optionee shall be entitled to receive, for the same aggregate consideration, the
same total number and kind of shares or other securities, cash or property that the owner of an equal number of outstanding shares of Common Stock immediately prior to the event requiring adjustment would own as a result of the event. If any such
event shall occur, appropriate adjustment shall also be made in the application of the provisions of this Section 14 and Section 15 with respect to Options and the rights of optionees after the event so that the provisions of such Sections
shall be applicable after the event and be as nearly equivalent as practicable in operation after the event as they were before the event. 

13.3 No Adjustment in Certain Cases. Except as hereinbefore expressly provided, the issue by the Company of shares of stock of
any class, or securities convertible into shares of stock of any class, for cash or property or for labor or services, either upon direct sale or upon the exercise of rights or warrants to subscribe therefor, or upon conversion of shares or
obligations ofthe Company convertible into such shares or other securities, shall not affect, and no adjustment by reason thereof shall be made with respect to, the number or price of shares of Common Stock then subject to outstanding options. 

  
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 13.4 Board Authority to Make Adjustments. Any adjustments under
this Section 14 will be made by the Board of Directors, whose determination as to what adjustments, if any, will be made and the extent thereof will be final, binding and conclusive. No fractional shares will be issued under the Plan on account
of any such adjustments. 
 14. Effect of Certain Transactions  

14.1 General. Except as provided in any Option Agreement or Restricted Stock Agreement to the contrary, if the
Company is merged with or into or consolidated with another corporation under circumstances where the stockholders of the Company immediately prior to such merger or consolidation do not own after such merger or consolidation shares representing at
least fifty percent (50%) ofthe voting power of the Company or the surviving or resulting corporation, as the case may be, or if shares representing fifty percent (50%) or more of the voting power of the Company are transferred to an Unrelated Third
Party, as hereinafter defined, or if the Company is liquidated, or sells or otherwise disposes of all or substantially all its assets (each such transaction is referred to herein as a “Change in Control Transaction”), the Board, or the
board of directors of any corporation assuming the obligations of the Company, may, in its discretion, take any one or more of the following actions, as to some or all outstanding Options or Restricted Stock Awards (and need not take the same action
as to each such Option or Restricted Stock Award): (i) provide that such Options shall be assumed, or equivalent Options shall be substituted, by the acquiring or succeeding corporation (or an affiliate thereof), provided that any such
Options substituted for Incentive Stock Options shall meet the requirements of Section 424(a) of the Code, (ii) upon written notice to the optionees, provide that all unexercised Options will terminate immediately prior to the consummation
of the Change in Control Transaction unless exercised by the optionee to the extent otherwise then exercisable within a specified period following the date of such notice, (iii) upon written notice to the grantees, provide that all unvested
shares of Restricted Stock shall be repurchased at cost, (iv) make or provide for a cash payment to the optionees equal to the difference between (A) the fair market value of the per share consideration (whether cash, securities or other
property or any combination of the above) the holder of a share of Common Stock will receive upon consummation of the Change in Control Transaction (the “Per Share Transaction Price”) times the number of shares
of Common Stock subject to outstanding vested Options (to the extent then exercisable at prices not equal to or in excess of the Per Share Transaction Price) and (B) the aggregate exercise price of such outstanding vested Options, in exchange
for the termination of such Options, or (v) provide that all or any outstanding Options shall become exercisable and all or any outstanding Restricted Stock A wards shall vest in part or in full immediately prior to such event. To the extent
that any Options are exercisable at a price equal to or in excess ofthe Per Share Transaction Price, the Board may provide that such Options shall terminate immediately upon the consummation of the Change in Control Transaction without any payment
being made to the holders of such Options. “Unrelated Third Party” shall mean any person who is not, on the date of adoption of this Plan by the Board, a holder of stock of any class or preference or any stock
option of the Company. 

  
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 14.2 Substitute Options. The Company may grant Options in substitution for
options held by employees, officers or directors of, or consultants or advisors to, another corporation who become employees, officers or directors of, or consultants or advisors to, the Company, as the result of a merger or consolidation of the
employing corporation with the Company or as a result of the acquisition by the Company of property or stock of the employing corporation. The Company may direct that substitute Options be granted on such terms and conditions as the Board considers
appropriate in the circumstances. 
 14.3 Restricted Stock. In the event of a business combination or other transaction of the
type detailed in Section 15.1, any securities, cash or other property received in exchange for shares of Restricted Stock shall continue to be governed by the provisions of any Restricted Stock Agreement pursuant to which they were issued,
including any provision regarding vesting, and such securities, cash, or other property may be held in escrow on such terms as the Board of Directors may direct, to insure compliance with the terms of any such Restricted Stock Agreement. 

15. No Special Employment Rights. Nothing contained in the Plan or in any Option Agreement or Restricted Stock Agreement
shall confer upon any optionee or holder of Restricted Stock any right with respect to the continuation of his or her employment by the Company or interfere in any way with the right of the Company at any time to terminate such employment or to
increase or decrease his or her compensation. 
 16. Other Employee Benefits. The amount of any compensation deemed to
be received by an employee as a result of the issuance of shares of Restricted Stock or the grant or exercise of an Option or the sale of shares received upon issuance of a Restricted Stock Award or exercise of an Option will not constitute
compensation with respect to which any other employee benefits of such employee are determined, including, without limitation, benefits under any bonus, pension, profit-sharing, life insurance or salary continuation plan, except as otherwise
specifically determined by the Board of Directors. 
 17. Amendment of the Plan. 

17.1 The Board may at any time, and from time to time, modify or amend in any respect or terminate the Plan. If shareholder approval is not
obtained within twelve months after any amendment increasing the number of shares authorized under the Plan or changing the class of persons eligible to receive Options under the Plan, no Options granted pursuant to such amendments shall be deemed
to be Incentive Stock Options and no Incentive Stock Options shall be issued pursuant to such amendments thereafter. 
 17.2 The termination
or any modification or amendment of the Plan shall not, without the consent of an optionee or the holder of Restricted Stock, adversely affect his or her rights under an Option or Restricted Stock Award previously granted to him or her. With the
consent of the recipient of Restricted Stock or optionee affected, the Board may amend outstanding Restricted Stock Agreements or Option Agreements in a manner not inconsistent with the Plan. 

  
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 18. Withholding. The Company shall have the right to
deduct from payments of any kind otherwise due to the optionee or recipient of Restricted Stock, any federal, state or local taxes of any kind required by law to be withheld with respect to issuance of any shares of Restricted Stock or shares issued
upon exercise of Options. Prior to delivery of any Common Stock pursuant to the terms of this Plan, the Board has the right to require that the optionee or recipient of Restricted Stock remit to the Company an amount sufficient to satisfy any
minimum tax withholding obligation. Subject to the prior approval of the Company, which may be withheld by the Company in its sole discretion, the obligor may elect to satisfy any minimum withholding obligations, in whole or in part, (i) by
causing the Company to withhold shares of Common Stock otherwise issuable, or (ii) by delivering to the Company a sufficient number of shares of Common Stock. The shares so withheld shall have a fair market value equal to such minimum
withholding obligation. The fair market value of the shares used to satisfy such minimum withholding obligation shall be determined by the Company as of the date that the amount of tax to be withheld is to be determined. A person who has made an
election pursuant to this Section 19 may only satisfy his or her withholding obligation with shares of Common Stock which are not subject to any repurchase, forfeiture, unfulfilled vesting or other similar restrictions. 

19. Effective Date and Duration of the Plan.  

19.1 Effective Date. The Plan shall become effective when adopted by the Board of Directors. If shareholder
approval is not obtained within twelve months after the date of the Board’s adoption of the Plan, no Options previously granted under the Plan shall be deemed to be Incentive Stock Options and no Incentive Stock Options shall be granted
thereafter. Amendments to the Plan not requiring shareholder approval shall become effective when adopted by the Board. Amendments requiring shareholder approval shall become effective when adopted by the Board, but if shareholder approval is not
obtained within twelve months of the Board’s adoption of such amendment, any Incentive Stock Options granted pursuant to such amendment shall be deemed to be non-statutory Options provided that such
Options are authorized by the Plan. Subject to this limitation, Options may be granted under the Plan at any time after the effective date and before the date fixed for termination of the Plan. 

19.2 Termination. Unless sooner terminated by action of the Board of Directors, the Plan shall terminate upon the
close of business on the day next preceding the tenth anniversary of the date of its adoption by the Board of Directors. 
 20.
Provision for Foreign Participants. The Board of Directors may, without amending the Plan, modify the terms of Option Agreements or Restricted Stock Agreements to differ from those specified in the Plan with respect to
participants who are foreign nationals or employed outside the United States to recognize differences in laws, rules, regulations or customs of such foreign jurisdictions with respect to tax, securities, currency, employee benefit or other matters.


  
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 21. Requirements of Law. The Company shall not be required to
sell or issue any shares under any Option or Restricted Stock Award if the issuance of such shares shall constitute a violation by the optionee, the Restricted Stock Award recipient, or by the Company of any provision of any law or regulation of any
governmental authority. In addition, in connection with the Act, the Company shall not be required to issue any shares upon exercise of any Option unless the Company has received evidence satisfactory to it to the effect that the holder of such
Option will not transfer such shares except pursuant to a registration statement in effect under the Act or unless an opinion of counsel satisfactory to the Company has been received by the Company to the effect that such registration is not
required in connection with any such transfer. Any determination in this connection by the Board shall be final, binding and conclusive. In the event the shares issuable on exercise of an Option are not registered under the Act or under the
securities laws of each relevant state or other jurisdiction, the Company may imprint on the certificate(s) appropriate legends that counsel for the Company considers necessary or advisable to comply with the Act or any such state or other
securities law. The Company may register, but in no event shall be obligated to register, any securities covered by the Plan pursuant to the Act; and in the event any shares are so registered the Company may remove any legend on certificates
representing such shares. The Company shall not be obligated to take any affirmative action in order to cause the exercise of an Option, the grant of any Restricted Stock Award or the issuance of shares pursuant thereto to comply with any law or
regulation of any governmental authority. 
 22. Conversion of Incentive Stock Options into
Non-Qualified Options; Termination. The Board of Directors, with the consent of any optionee, may in its discretion take such actions as may be necessary to convert such optionee’s
Incentive Stock Options (or any installments or portions of installments thereof) that have not been exercised on the date of conversion into non-statutory Options at any time prior to the expiration of such
Incentive Stock Options, regardless of whether the optionee is an employee of the Company or a parent or subsidiary of the Company at the time of such conversion. At the time of such conversion, the Board of Directors (with the consent of the
optionee) may impose such conditions on the exercise of the resulting non-statutory Options as the Board of Directors in its discretion may determine, provided that such conditions shall not be inconsistent
with this Plan. Nothing in this Plan shall be deemed to give any optionee the right to have such optionee’s Incentive Stock Options converted into non-statutory Options, and no such conversion shall occur
until and unless the Board of Directors takes appropriate action. The Board of Directors, with the consent of the optionee, may also terminate any portion of any Incentive Stock Option that has not been exercised at the time of such termination.

 23. Non-Exclusivity of this Plan;
Non-Uniform Determinations. Neither the adoption of this Plan by the Board of Directors nor the approval of this Plan by the stockholders of the Company shall be construed as creating any
limitations on the power of the Board of Directors to adopt such other incentive arrangements as it may deem desirable, including, without limitation, the granting of stock options otherwise than under this Plan, and such arrangements may be either
applicable generally or only in specific cases. 
 The determinations of the Board of Directors under this Plan need not be uniform and may
be made by it selectively among persons who receive or are eligible to receive Options or Restricted Stock Awards under this Plan (whether or not such persons are similarly situated). Without limiting the generality of the foregoing, the Board of
Directors shall be entitled, among 

  
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other things, to make non-uniform and selective determinations, and to enter into non-uniform and selective Option
Agreements and Restricted Stock Agreements, as to (a) the persons to receive Options or Restricted Stock Awards under this Plan, (b) the terms and provisions of Options or Restricted Stock Awards, (c) the exercise by the Board of
Directors of its discretion in respect of the exercise of Options pursuant to the terms of this Plan, and (d) the treatment of leaves of absence pursuant to Section 10 hereof. 

24. Governing Law. This Plan and each Option or Restricted Stock Award shall be governed by the laws of The Commonwealth of
Massachusetts, without regard to its principles of conflicts of law. 

  
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 APPENDIX A 

TO SQZ BIOTECHNOLOGIES COMPANY 2014 STOCK INCENTIVE PLAN 

FOR CALIFORNIA RESIDENTS ONLY 

This Appendix to the SQZ Biotechnologies Company 2014 Stock Incentive Plan (the “Plan”) shall have application only to participants
in the Plan who are residents of the State of California. Capitalized terms contained herein shall have the same meanings given to them in the Plan, unless otherwise provided in this Appendix. Notwithstanding any provision contained in the Plan
to the contrary and to the extent required by applicable law, the following terms and conditions shall apply to all Options and Restricted Stock Awards (collectively “Awards”) granted to residents of the State of California, until such
time as the Common Stock becomes subject to registration under the Securities Act of 1933:  
 1. Awards shall be nontransferable other
than by will or the laws of descent and distribution. Notwithstanding the foregoing, and to the extent permitted by Section 422 of the Code, the Board, in its discretion, may permit distribution of an Award to an inter vivos or testamentary
trust in which the Award is to be passed to beneficiaries upon the death of the trustor (settlor), or by gift to “immediate family” as that term is defined in Rule 16a-1 (e) of the United States
Exchange Act of 1934. 
 2. Unless employment is terminated for Cause, the right to exercise an Option in the event of termination of
employment, to the extent that the optionee is otherwise entitled to exercise an Option on the date employment terminates, shall be 
 (a)
at least six months from the date of termination of employment if termination was caused by death or permanent disability; and 
 (b) at
least 30 days from the date of termination if termination of employment was caused by other than death or permanent disability; 
 (c) but
in no event later than the remaining term of the Option. 
 3. Any Award exercised before shareholder approval is obtained shall be
rescinded if shareholder approval is not obtained within 12 months of the Board’s adoption of the Plan. 












 SQZ Biotechnologies Company (the “Company”)

 STOCK OPTION AGREEMENT 

The Option described in this Stock Option Agreement (the “Option Agreement”) was granted by the Company on the date of
grant set forth below (the “Date of Grant”) pursuant to the Company’s 2014 Stock Incentive Plan, as amended from time to time (the “Plan”), which is incorporated herein by reference and made a
part hereof. The holder of this Option (the “Holder”) hereby accepts this Option subject to all the terms and provisions of the Plan and this Option Agreement and agrees that (a) in the event of any conflict between the
terms hereof and those of the Plan, the terms of the Plan shall prevail, and (b) all decisions under and interpretations of the Plan by the Board of Directors of the Company (the “Board”) or of a committee that the Board
appoints (the “Committee”) shall be final, binding and conclusive upon the Holder and his or her heirs and legal representatives. 
  

	1.	 Name of Holder:  



 

	2.	 Date of Grant:1 



 

	3.	 Vesting Commencement Date:  



 

	4.	 Maximum number of shares for  



	    	 which this Option is exercisable: 



 

	5.	 Exercise (purchase) price per share:  



 

	6.	 Type of Option: [Incentive Stock Option/Non-statutory Stock
Option] 


  

	7.	 Expiration Date of Option (the “Expiration Date”):2  


  

	8.	 Vesting Schedule: [Vesting schedule to be specified in individual Option Agreements.]



 Notwithstanding the foregoing, all vesting shall cease upon the date the Holder is no longer a Service
Provider and the Option will immediately terminate and be forfeited as to any portion that is not vested as of such date. For purposes of this Option Agreement, “Service Provider” means an employee, advisor, director or consultant of the
Company or one of its subsidiaries. 
  

	9.	 Method of Exercise: This Option may be exercised by the delivery to the Company of written notice in a
form acceptable to the Company setting forth the number of shares of Common Stock, par value $0.001 per share (the “Common Stock”), of the Company (the “Shares”) with respect to which the Option is to
be exercised, together with payment by one of the following methods: 


 cash or a personal, certified or bank check or
postal money order payable to the order of the Company for an amount equal to the exercise price for the number of Shares being purchased; or 

 

	1 	 The Date of Grant should be the date that the Board approves the option. 



	2 	 The Expiration Date should be the day prior to the 10th
anniversary of the Date of Grant. 














 with the consent of the Company, any of the other methods set forth in the
Plan. 
 As an additional condition to exercise of this Option, the Holder shall deliver to the Company an investment letter
in form and substance satisfactory to the Company. No such investment letter shall be required as a condition to such exercise at any time when there shall be an effective registration statement under the Securities Act of 1933, as amended (the
“Act”) covering the Shares for which this Option may be exercised. 
 If required by the Company, the
Holder shall, as a condition precedent to exercising this Option, become a party to (i) the Voting Agreement, dated as of June 15, 2015, by and among the Company and the parties thereto, as may be amended and/or restated from time to time,
and (ii) the Right of First Refusal and Co-Sale Agreement, dated as of June 15, 2015, by and among the Company and the parties thereto, as may be amended and/or restated from time to time, and shall
execute and deliver to the Company a joinder to such agreements in a form acceptable to the Company. 
  

	10.	 Termination of Option. This Option may not be exercised to any extent after, and shall terminate on, the
earliest to occur of: 


  

	 	(i)	 the Expiration Date; 



 

	 	(ii)	 immediately upon the Holder’s termination as a Service Provider for Cause (as defined in the Plan);



  

	 	(iii)	 90 days after the Holder ceases to be a Service Provider for any reason other than Cause or due to death or
“permanent and total disability” (within the meaning of the Plan); or 


  

	 	(iv)	 180 days after the Holder ceases to be a Service Provider due to the Holder’s “permanent and total
disability” or death. 


 Holder acknowledges that an Incentive Stock Option exercised more than three months after
Holder’s termination of status as an employee of the Company, other than by reason of death or “permanent and total disability,” will be taxed as a non-statutory Stock Option. 

 

	11.	 Company’s Right of First Refusal. Any Shares issued pursuant to exercise of this Option shall be
subject to the Company’s right of first refusal as set forth at Appendix A. 


  

	12.	 Lock-Up Agreement. The Holder agrees that upon the request of
the Company or the managing underwriter(s) of any offering of securities of the Company that is the subject of a registration statement filed under the Act, for a period of time (not to exceed 180 days, plus such additional number of days (not to
exceed 35) as may reasonably be 



  
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requested to enable the underwriter(s) of such offering to comply with Rule 2711(f) of the Financial Industry Regulatory Authority or any amendment or successor thereto) from the effective date
of the registration statement under the Act for such offering, the Holder will not sell, make any short sale of, loan, grant any option for the purchase of, or otherwise dispose of any Shares issued pursuant to the exercise of this Option, without
the prior written consent of the Company and such underwriters. The Holder further agrees to execute such agreements as may be reasonably requested by the underwriters that are consistent with this Section 12 or that are necessary to give
further effect hereto. 

  

	13.	 Tax Withholding. The Company’s obligation to deliver Shares shall be subject to the Holder’s
satisfaction of any federal, state and local income and employment tax withholding requirements arising in connection with the Option. 


  

	14.	 Special Tax Consequences. If this Option is designated as an Incentive Stock Option:



  

	 	(i)	 The Holder acknowledges that to the extent the aggregate fair market value of shares (determined as of the time
the option with respect to the shares is granted) with respect to which stock options intended to qualify as “incentive stock options” under Section 422 of the Internal Revenue Code of 1986, as amended (the
“Code”), including the Option, are exercisable for the first time by the Holder during any calendar year exceeds $100,000 or if for any other reason such stock options do not qualify or cease to qualify for treatment as
“incentive stock options” under Section 422 of the Code, such stock options (including this Option) will be treated as non-qualified stock options. The Holder further acknowledges that the rule
set forth in the preceding sentence will be applied by taking this Option and other stock options into account in the order in which they were granted, as determined under Section 422(d) of the Code. 



 

	 	(ii)	 The Holder will give prompt written notice to the Company of any disposition or other transfer of any Shares
acquired under this Option Agreement if such disposition or other transfer is made (a) within two (2) years from the Date of Grant or (b) within one (1) year after the transfer of such Shares to the Holder. Such notice will
specify the date of such disposition or other transfer and the amount realized, in cash, other property, assumption of indebtedness or other consideration, by the Holder in such disposition or other transfer. 



 

	15.	 Notice. Any notice to be given to the Company hereunder shall be deemed sufficient if addressed to the
Company and delivered to the office of the Company, SQZ Biotechnologies Company, 100 Morrissey Blvd, Venture Development Center, Boston, MA 02125, attention of the Chief Executive Officer, or such other address as the Company may hereafter
designate. 



  
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 Any notice to be given to the Holder hereunder shall be deemed sufficient if addressed to
and delivered in person to the Holder at his or her address furnished to the Company or when deposited in the mail, postage prepaid, addressed to the Holder at such address. 

[signature page follows] 

  
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 IN WITNESS WHEREOF, the parties have executed this Option Agreement, or caused this Option
Agreement to be executed, as of the Date of Grant. 
  

			
	SQZ Biotechnologies Company


 
			
		
	By:	 	 


 
			
	Name:	 	Armon Sharei, Ph.D.


 
			
	Title:	 	Chief Executive Officer


 The undersigned Holder hereby acknowledges receipt of a copy of the Plan and this Option Agreement (including Appendix A
hereto), and agrees to the terms of the Option, this Option Agreement and the Plan. 

	
	
	   

	Name:


  
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 APPENDIX A 

Right of First Refusal 

1. General. Prior to the effective date of a registration statement under the Act covering any shares of the
Company’s Common Stock and until such time as the Company shall have effected a public offering of its Common Stock registered under the Act, in the event that, at any time when the Holder (which term for purposes of this Appendix A shall mean
the Holder and his or her executors, administrators and any other person to whom this Option may be transferred by will or the laws of descent and distribution) is permitted to do so, the Holder desires to sell, assign or otherwise transfer any of
the Shares issued upon the exercise of this Option, the Holder shall first offer such Shares to the Company by giving written notice of the Holder’s desire so to sell, assign or transfer such Shares. 

2. Notice of Intended Transfer. The notice shall state the number of Shares offered, the name of the person or
persons to whom it is proposed to sell, assign or transfer such Shares and the price at which such Shares are intended to be sold, assigned or transferred. Such notice shall constitute an offer to the Company for the Company to purchase the number
of Shares set forth in the notice at a price per share equal to the price stated therein. 
 3. Company to Accept or Decline
Within 30 Days. The Company may accept the offer as to all, but not less than all, such Shares by notifying the Holder in writing within 30 days after receipt of such notice of its acceptance of the offer. If the offer is accepted,
the Company shall have 60 days after such acceptance within which to purchase the offered Shares at a price per share as aforesaid. Upon the closing of such purchase, the Holder shall transfer to the Company the Shares offered in the notice, free of
all liens, encumbrances and rights of others, and shall deliver any certificate(s) representing such Shares, as well as the duly executed stock powers accompanying such certificate(s), to the Company. If within the applicable time periods the Holder
does not receive notice of the Company’s intention to purchase the offered Shares, or if payment in full of the purchase price is not made by the Company, the offer shall be deemed to have been rejected and the Holder may transfer title to such
Shares within 90 days from the date of the Holder’s written notice to the Company of the Holder’s intention to sell, but such transfer shall be made only to the proposed transferee and at the proposed price as stated in such notice and
after compliance with any other provisions of this Option applicable to the transfer of such Shares. 
 4. Transferred Shares
to Remain Subject to Rights of the Company. Shares that are so transferred to such transferee shall remain subject to the provisions of the Plan and the Option Agreement, including the rights of the Company set forth in this Appendix
A, and any other applicable agreements governing the Shares that are transferred. As a condition to such transfer, such transferee shall execute and deliver all such documents as the Company may require to evidence the binding agreement of such
transferee so to remain subject to the rights of the Company. 

  
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 5. Remedies of Company. No sale, assignment, pledge or other
transfer of any of the Shares covered by this Option shall be effective or given effect on the books of the Company unless all of the applicable provisions of this Appendix A have been duly complied with, and the Company may inscribe on the face of
any certificate representing any of such Shares a legend referring to the provisions of this Appendix A. If any transfer of Shares is made or attempted in violation of the foregoing restrictions, or if Shares are not offered to the Company as
required hereby, the Company shall have the right to purchase such Shares from the owner thereof or his transferee at any time before or after the transfer, as herein provided. In addition to any other legal or equitable remedies which it may have,
the Company may enforce its rights by actions for specific performance (to the extent permitted by law) and may refuse to recognize any transferee as one of its stockholders for any purpose, including, without limitation, for purposes of dividend
and voting rights, until all applicable provisions hereof have been complied with. 
 6. Shares Subject to Right of First
Refusal. For purposes of the Company’s right of first refusal pursuant to this Appendix A, the term “Shares” shall include any and all new, substituted or additional securities or other property issued to the Holder, by
reason of his or her ownership of Common Stock pursuant to the exercise of this Option, in connection with any stock dividend, liquidating dividend, stock split or other change in the character or amount of any of the outstanding securities of the
Company, or any consolidation, merger or sale of all or substantially all of the assets of the Company. 
 7. Legends on Stock
Certificates. Any certificate representing Shares subject to the provisions of this Appendix A may have endorsed thereon one or more legends, substantially as follows: 

 

	 	(i)	 “Any disposition of any interest in the securities represented by this certificate is subject to
restrictions, and the securities represented by this certificate are subject to certain options, contained in a certain agreement between the record holder hereof and the Company, a copy of which will be mailed to any holder of this certificate
without charge upon receipt by the Company of a written request therefor.” 


  

	 	(ii)	 “The shares of stock represented by this certificate have not been registered under the Securities Act of
1933 (the “Act”) or under the securities laws of any state and may not be pledged, hypothecated, sold or otherwise transferred unless such shares have been registered under the Act or unless the Company has received an opinion of counsel
satisfactory to the Company, in form and substance satisfactory to the Company, that such registration is not required.” 



8. Right of First Refusal to Lapse Upon Registration. The restrictions imposed by this Appendix A shall terminate
in all respects upon the effective date of a registration statement under the Act covering any of the Company’s Common Stock. 
 * * * *
* 

  
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