Rimsu lfuron Dietary Expo sure and Ri sk Assessment DP Number: 418154 PC Code: 129009

UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON , D.C. 20460

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION



### MEMORANDUM

Date: 

### 03/17/2014

SUBJEC T: 

### Rimsulfuron C hr onic Aggregate Dietary (Food and Drinking Water) Exposure and Risk Assessment fo r the Section 3 Registration on Acetolactase Synt h ase (A LS ) Tol erant Grain Sorghum.

PC Code: 129009 Decision No.: 473406 P eti tionNo. : 2F8131 Ri s k Assess Type: NA TXRN o .: NA MRIDNo.: NA DP B arcode: D418154 Registration Nos : 352-7 4 8, 352 -861 Regulatory Action: Sect ion 3 Registration Case No.: NA CAS No.: 122931-48-0 40 CF R: 180.478

FROM:

THROUGH:

TO : 

### Meher et Negussie, Chemist 

## Neltcvcf 

## ;J?Jv.SSrt?.... Risk Assessment Branch III (RA B3) Health Effects Division ( H ED; 7509P)

Douglas Dotson Ph.D.,

# Se**·** r Che mis t

# ~. 

# J;J;;;nv
Kristin Rury
, Biologis t 

# VJ

Di etary Expos ure Science d · Counc il Health Effects Di vis i on (7509P) and Christine Oli n ge r , Bran c h Chi ef /J 

# ;J / .//
RAB3 / HED (7509P)

## (Y-~
Cassi. Walls, Ph.D.
, Senior Bi olog i st/R i sk Assessor HED /RAB3 (7509P) and Kable Davis
, RM 25 Herbicide Branch ( HB ) Registration Division (RD ; 

### 7505P)

Pa ge I of 1 2Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 418154 PC Code: 129009



### I. Executive Summary

A chronic aggregate dietary (food and drinking water) exposure and risk assessment was conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM-FCID) Version 3.16. This software uses 2003-2008 food consumption data from t he U.S. Department of Agriculture's (USDA's) Nationa l Health and Nutrit ion Examination Survey, What We Eat in America, (N HA NES/WWEIA)

. The analysis was conducted in support of a human health risk assessment for the proposed Section 3 request on sorghum tolerant to acetolactate synthase (ALS) inhibitors. This memorandum was reviewed by
two peer reviewers of the DESAC, per DESAC SOP 2012.1.

Acute and Cancer Dietary Exposure

No acute dietary toxicity endpoint could be identified based on the toxicology data currently available for rimsulfuron ; therefore
, an acute assessment was not performed

.

The Cancer Assessment Review Committee (CARC) classified rimsulfuron as "not likely to be carcinogenic to humans;" therefore, a cancer dietary assessment was not performed.

Chronic Dietary Exposure Results and Characterization

The unrefined chronic dietary exposure assessment was based on the assumption that rimsulfuron residues are present at tolerance levels in all commodities for which tolerances have been established and that 100% of t ho se crops are trea t ed. DEEM Version 7

. 81 default processing factors were applied to all processed commodities for whic h they were ava ilabl e. Estimated drinking water concentration (EDWC) values were incorporated directly into the dietary assessment.

The chronic dietary exposure estimates for food and water are well below HED's level of

concern for the general U.S. population and all population subgroups. The dietary exposure is estimated at 0.000807 mg/kg/day for the U.S. population ( < 1% of th e chronic population adjusted dose (cPAD)) and 0.001710 (1.4% of the cPAD) for all infants, the population subgroup with the highest estimated chronic dietary exposure to rimsulfuron.

I

. Introduction

Diet ary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments , the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the point of departure (PoD; e.g. no observed adverse effect level (NOAEL), lowest observed adver se e f fect l eve l (LOAEL), etc.) divided by the required uncertainty or safety factors.

For acute and non-cancer chronic exposures , HED is concerned when estimated dietary risk exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in

more detail are available on the EPA/pesticides website: " Available Information on Assessing

Page 2 of 12Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 418154

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### Exposure from Pesticides, A User’s Guide,” 21

- JUN

- 2000, web link: http:// www.epa.gov/fedrgstr/EPA

- PEST/2000/July/Day

- 12/6061.pdf ; or see SOP 99.6 ( 20

- AUG

- 1999 ).

The most recent HED dietary risk assessment for rimsulfuron was conducted by E. Holman (DP# D 394389
, 10/28/2011 )

.

II. Residue Information

Plants/Livestock: The nature of the residue of rimsulfuron in plants and livestock c ommodities is rimsulfu r on ( D360852, D. Rate
, 8 / 13 /2009
, and Metabolism Assessment Review Committee ( MARC ) report, 0 2/11/ 19 98).

Drinking Water : T he residue s of concern for drinking water includ e rimsulfuron and major degradates IN

- 70941 and IN

- 70942 ( D P# D 416833 , C. Walls, 12/18/2013).

Tolerances: Permanent tolerances are established for residues of rimsulfuron at levels ranging from 0.01 ppm in/on various tree fruits, tree nuts and grapes to 0.1 ppm in/on potatoes and field corn commodities [40 CFR §180.478(a)].
For the proposed new use o n sorghum, a tolerance level of 0.0 1 ppm is recommended ( DP# D 4 18153 , M. Negussie, 03 / 17 /2014 ).

Residue Data used for the Chronic Assessment: The unrefin ed chronic dietary assessment is based on the assum ption that rimsulfuron residues are present at the proposed or registered tolerance levels in all commodities and that 100% of those crops are treated. D EEM Version 7.81 default processing factors were ap plied to all processed commodities for which they were available

. In the processing study for soybean oil, residues did not concentrate. Therefore, the processing factor was left at 1.0.

The USDA Pesticide Data Program (PDP) monitored pesticide residu es in catfish in 2008, 2009, and 2010. In general, pesticide residues would not be expected to be found in fish unless the pesticide bioaccumulates or has an aquatic use. To determine whether or not residues are present in fish, HED now routinely checks PDP monitoring data regardless of the pesticide’s uses and physicochemical properties. However, PDP did not analyze catfish samples for rimsulfuron. As a result, residues in fish were not included in the assessment.

III. Percent Crop Treated Inform ation

100% CT was assumed for all crops.

IV. Drinking Water Data

The drinking water residues used in t he dietary risk assessment were provided by the Environmental Fate and Effects Division ( EFED; M. Barrett, D414506, 03/13 /20 14 )

. W aterRimsulfuron Dietary Exposure and Risk Assessment DP Number: 418154

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### residues wer e incorporated directly in to the DEEM

- FCID assessment under the food categories “water, direct, all sources” and “w ater, indirect, all sources.”

Rimsulfuron foliar applications using ground and aerial sprays impact both surface and ground water drinking water sources given that it possesses similar physical chemical properties and persistence to other chemicals which are known to translocate to these media.

The residue of concern in drinking water is parent rimsulfuron including the degra dates (IN

70941 and IN

- 70942 ) ( ( D P# D 416833, C. Walls, 12/18/2013). The estimate is based on

a ssessment of all registered uses using the Tier 1 model PRZM

- GW ( Pesticide Root Zone Model

- Ground Water)

. The model s and their description s are available at the EPA internet s ite: http://www.epa.gov/oppefed1/models/water/

. The maximum estimated drinking water concentrations (EDWCs) are presented below in Table 1

. In this updated drinking water exposure assessment it has been determined that exposure from the current and proposed uses should not exceed 19.7 μg/L (ppb) for chronic and cancer exposure. A value of 22.2 ppb was provided for an acute assessment; however, an acute assessment was not performed. These values ref lect a predicted higher potential exposure level from groundwater sourced drinking water supplies than surface water supplies. The Table 1 values are based on uses from several crop sites with higher single and seasonal maximum application rates than is p roposed for the new use on ALS tolerant sorghum.

Table 1. Maximum Tier I Rimsulfuron EDWCs for drinking water based on application of rimsulfuron to crops with highest rates and exposure potential.

Crops (scenario) Highest Daily Value (Acute) Post

- Br eakthrough Average (Chronic and Cancer) All 22.2 19.7 Based upon the highest values from six standard Tier 1 groundwater scenarios (i.e., a WI scenario based upon a predominantly corn production area ) . The EDWCs are representative for crop use sites wit h higher allowed application rates than for the proposed use on ALS tolerant sorghum.



### V. DEEM

- FCID Program and Consumption Information

A r imsulfuron chronic dietary exposure assessment was conducted using the DEEM

- FCID, Version 3.16, which incorporates 2 003

- 2008 consumption data from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non

- consecutive survey days. Foods “as consumed” (e.g., apple pie) are linked to EPA

- defined food commodities (e.g ., apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged fo r the entire U.S. population and within population subgroups. However, for acute exposure assessment, consumption data are retained as individual consumption events. Based on analysis of the 2003

- 2008 WWEIA consumption data, which took into account dieta ry patterns and survey respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), childrenRimsulfuron Dietary Exposure and Risk Assessment DP Number: 418154

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### 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, adults 20

- 4 9, females 13

- 49, and adults 50

- 99 years old.

For chronic dietary exposure assessment, an estimate of the residue level in each food or food

form (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average daily consumpt ion estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at t he total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup.

VI. Toxicological Information

No acute hazard, attributable to a single dose, wa s identified; therefore, an acute dietary endpoint was not selected for quantitative risk assessment.

The Cancer Assessment Review Committee (CARC) classified rimsulfuron as “ n ot likely to be carcinogenic to humans ; ” therefore, a cancer assessment was not performed.

The toxicity endpoints pertinent for human health dietary risk assessment are summarized in Table 2

.

Table 2

. Summary of Toxicological Doses and Endpoints for Rimsulfuron for Use in Human Dietary Risk Assessments
Exposure Scenario Point of

Departure/Uncertainty, FQPA Safety Factors RfD, PAD, Level of Concern Study and Toxicological Effects

Acute Dietary (females 13

- 49) Acute Dietary (general population) None No appropriate endpoint attributable to a single dose is available.

Chr onic Dietary (all populations) NOAEL=1 1.8 mg/kg/day

UF A = 10X UF H = 10X FQPA SF = 1X cPAD = 0.1 18 mg/kg/day Combined Chronic/Carcinogenicity

Rat LOAEL= 121 mg/kg/day in males; 568 mg/kg/day in females (NOAEL=163 mg/kg/day), based on decre ased body weight gains and liver effects. Cancer (oral, dermal, inhalation) Classificat i on:

Rimsulfuron is classified as a “ not l ikely “human carcinogen. Point of Departure (P o D) = A data point or an estimated point that is derived from observed dose

- response data and used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = uncertainty fa ctor. UF A = extrapolation from animal to human (int er species). UF H = potential variation inRimsulfuron Dietary Exposure and Risk Assessment DP Number: 418154

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Page 6 of 12 sensitivity among members of the human population (int ra species). FQPA SF = FQPA Safety Factor. PAD = population adjusted dose (a = acute, c = chronic).



### V I I. Results/Discussion

As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of the c PAD. The DEEM

- FCI D analyses estimate the dietary exposure of the U.S. population and various population subgroups. The results reporte d in Table 3 are for the general U.S. Population, all infants (<1 year old), children 1

- 2, children 3

- 5, children 6

- 12, youth 13

- 19, females 13

- 49, adults 20

- 49, and adults 50

- 99 years.
Rimsulfuron chronic dietary (food + water) exposure estimates using the DEEM

- FCID software are well below HED’s level of concern for the U.S. population and each of the population subgroups. Dietary exposure was estimated to be 0.000807 mg/kg/day for the U.S. population (<1% of the cPAD) and 0.00 1710 mg/kg/day (1 .4 % of t he cPAD) for all infants, the most high ly exposed population subgroup

. The estimated exposures and risks f rom residues of rimsulfuron in food and water are summarized in Table 3

.

Table 3 . Chronic Aggregate Dietary (Food + Drinking Water) Exposure and Ri sk for Rimsulfuron

Population Subgroup Exposure (mg/kg/day) % cPAD

General U.S. Population 0.000 8 07 <1
All Infants (< 1 year old) 0.00 17 10 1. 4

Children 1

- 2 years old 0.001658 1.4

Children 3

- 5 years old 0.00 1 4 73 1. 2

Children 6

- 12 years old 0.00 100 2 < 1

Youth 13

- 19 years old 0.000 7 24 <1

Adults 20

- 49 years old 0.000 7 43 <1

Adults 50

- 99 years old 0.000 6 52 <1

Females 13

- 49 years old 0.000 7 2 4 <1

1 The population subgroup with the highest estimated chronic dietary (food + drinking water) exposure and risk is indicated by bold text.



### VI I I. Characterization of Inputs/Outputs

These chronic dietary exposure and risk estimates are highly conservative

. T hey are based on the assum ption that 100% of crops with tolerances are treated with rimsulfuron
, and that re sidues in foods “ as eaten ” are present at tolerance levels

. In addition, d rinking water exposure estimates

are conservative estimates generated by the PR Z M

- GW M odel.Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 418154

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### Dietary exposure estimates could be refined through the use of anticipated residues
, p ercent crop treated data, empirical processing factors, and/or refined estimated drinking water concentrations. However, a s estimated exposures and risks using conservative assumptions are well below HED’s level of concern, such refinement is not warrante d.

I X

. Conclusions

This unrefined chronic dietary ex posure analysis using DEEM

- FC ID indicates that chronic dietary exposure to rimsulfuron from food and drinking water is well below HED’s level of concern for this pesticide. Estimated chronic dietary ex posures are ≤ 1 .4 % of the cPAD for the general U.S. population and all population subgroups.

X. List of Attachments

1. Attachment 1

. Chronic Food and Water Residue Input file

. 2. Attachment 2

. C hronic Results files: Food and Water

. 3. Attachment 3

. C hronic Results files: F ood Alone.Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 418154

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### Attachment 1

. Chronic Food and Water Input File

Filename: C: \ Users \ mnegussi \ Documents \ DEEM Version 3.16 \ Rimsulfuron \ Chronic_Rimsulfuron2013.R08 Chemical: Rimsulfuron RfD(Chronic): .118 mg/kg bw/day NOEL(Chronic): 11.8 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 03

- 04

- 2014/13:43:02 Program ver. 3.16, 03

- 08

- d Comment: Use on sorghum

----------------------------------------------------------------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ ------ ------- 9500177000 O Grape, leaves 0.010000 1.000 1.000 9500178000 O Grape, raisin 0.010000 4.300 1.000 0101100000 1AB Chicory, roots 0.010000 1.000 1.000 0103296000 1C Potato, chips 0.100000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.100000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes)

- b 0.100000 6.500 1.000 0103298000 1C Potato, flour 0.100000 6.500 1.000 0103298 001 1C Potato, flour

- babyfood 0.100000 6.500 1.000 0103300000 1C Potato, tuber, w/o peel 0.100000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel

- babyfood 0.100000 1.000 1.000 0103299000 1C Potato, tuber, w /peel 0.100000 1.000 1.000 0103299001 1C Potato, tuber, w/peel

- babyfood 0.100000 1.000 1.000 0200101000 2 Chicory, tops 0.010000 1.000 1.000 0603348000 6C Soybean , flour 0.0100 00 1.000 1.000 0603348001 6C Soybean, flour

- babyfood 0.010000 1.000 1.000 0600350000 6 Soybean, oil 0.010000 1.000 1.000 0600350001 6 Soybean, oil

- babyfood 0.010000 1.000 1.000 06003 47000 6 Soybean, seed 0.010000 1.000 1.000 0600349000 6 Soybean, soy milk 0.010000 1.000 1.000 0600349001 6 Soybean, soy milk

- babyfood or in 0.010000 1.000 1.000 0600349001 6 Soybean, veget able 0.010000 1.000 1.000 0801374000 8A Tomatillo 0.050000 1.000 1.000 0801375000 8A Tomato 0.050000 1.000 1.000 0801380000 8A Tomato, Tree 0.0500 00 1.000 1.000 0801378000 8A Tomato, dried 0.050000 14.300 1.000 0801378001 8A Tomato, dried

- babyfood 0.050000 14.300 1.000 0801379000 8A Tomato, juice 0.050000 1.500 1.000 08013 76000 8A Tomato, paste 0.050000 5.400 1.000 0801376001 8A Tomato, paste

- babyfood 0.050000 5.400 1.000 0801377000 8A Tomato, puree 0.050000 3.300 1.000 0801377001 8A Tomato, puree

- babyfood 0.050000 3.300 1.000 0801375001 8A Tomato

- babyfood 0.050000 1.000 1.000 1001106000 10A Citron 0.010000 1.000 1.000 1001107000 10A Citrus hybrids 0.01 0000 1.000 1.000 1001108000 10A Citrus, oil 0.010000 1.000 1.000 1003180000 10C Grapefruit 0.010000 1.000 1.000 1003181000 10C Grapefruit, juice 0.010000 2.100 1.000 100 2197000 10B Kumquat 0.010000 1.000 1.000 1002199000 10B Lemon 0.010000 1.000 1.000 1002200000 10B Lemon, juice 0.010000 2.000 1.000 1002200001 10B Lemon, juice

- babyfood 0.010000 2.000 1.000 1002201000 10B Lemon, peel 0.010000 1.000 1.000 1002206000 10B Lime 0.010000 1.000 1.000 1002207000 10B Lime, juice 0. 010000 2.000 1.000 1002207001 10B Lime, juice

- babyfood 0.010000 2.000 1.000 1001240000 10A Orange 0.010000 1.000 1.000 1001241000 10A Orange, juice 0.010000 1.800 1.000 1 001241001 10A Orange, juice

- babyfood 0.010000 1.800 1.000 1001242000 10A Orange, peel 0.010000 1.000 1.000 1003307000 10C Pummelo 0.010000 1.000 1.000 1001369000 10A Tangerine 0.010000 1.000 1.000 1001370000 10A Tangerine, juice 0.010000 2.300 1.000Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 418154

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Page 9 of 12 1100009000 11 Apple, dried 0.010000 8.000 1.000 1100009001 11 Apple, dried

- babyfood 0.010000 8.000 1.000 1100007000 11 Apple, fruit with peel 0.010000 1.000 1.000 1100010000 11 Apple, juice 0.010000 1.300 1.000 1100010001 11 Apple, juice

- babyfood 0.010000 1.300 1.000 1100008000 11 Apple, peeled fruit 0.010000 1.000 1.000 1100008001 11 Apple, peeled fruit

- babyfood 0.010000 1.000 1.000 1100011000 11 Apple, sauce 0.010000 1.000 1.000 1100011001 11 Apple, s auce
- babyfood 0.010000 1.000 1.000 1100129000 11 Crabapple 0.010000 1.000 1.000 1100173500 11 Goji berry 0.050000 1.000 1.000 1100210000 11 Loquat 0.010000 1.000 1.000 1100266000 11 Pear 0.010000 1.000 1.000 1100267000 11 Pear, dried 0.010000 6.250 1.000 1100268000 11 Pear, juice 0.010000 1.000 1.000 1100268001 11 Pear, juice

- babyfood 0.010000 1.000 1.000 1100266001 11 Pear

- babyfood 0.010000 1.000 1.000 1100310000 11 Quince 0.010000 1.000 1.000 1202012000 12B Aprico t 0.010000 1.000 1.000 1202013000 12B Apricot, dried 0.010000 6.000 1.000 1202014000 12B Apricot, juice 0.010000 1.000 1.000 1202014001 12B Apricot, juice

- babyfood 0.010000 1.000 1.000 1202012001 12B Apricot

- babyfood 0.010000 1.000 1.000 1201090000 12A Cherry 0.010000 1.000 1.000 1201091000 12A Cherry, juice 0.010000 1.500 1.0 00 1201091001 12A Cherry, juice

- babyfood 0.010000 1.500 1.000 1201090001 12A Cherry

- babyfood 0.010000 1.000 1.000 1202230000 12B Nectarine 0.010000 1.000 1.000 1202260000 12B Peac h 0.010000 1.000 1.000 1202261000 12B Peach, dried 0.010000 7.000 1.000 1202261001 12B Peach, dried

- babyfood 0.010000 7.000 1.000 1202262000 12B Peach, juice 0.010000 1.000 1.000 1202262001 12B Peach, juice

- babyfood 0.010000 1.000 1.000 1202260001 12B Peach

- babyfood 0.010000 1.000 1.000 1203285000 12C Plum 0.010000 1.000 1 .000 1203287000 12C Plum, prune, dried 0.010000 5.000 1.000 1203287001 12C Plum, prune, dried

- babyfood 0.010000 5.000 1.000 1203286000 12C Plum, prune, fresh 0.010000 1.000 1.000 1203286001 12C Pl um, prune, fresh

- babyfood 0.010000 1.000 1.000 1203288000 12C Plum, prune, juice 0.010000 1.400 1.000 1203288001 12C Plum, prune, juice

- babyfood 0.010000 1.400 1.000 1203285001 12C Plum

- babyfood 0.010000 1.000 1.000 1301055000 13A Blackberry 0.010000 1.000 1.000 1301056000 13A Blackberry, juice 0.010000 1.000 1.000 1301056001 13A Blackberry, juice

- babyfood 0.010000 1.000 1.000 1302057000 13B Blueberry 0.010000 1.000 1.000 1302057001 13B Blueberry

- babyfood 0.010000 1.000 1.000 1301058000 13A Boysenberry 0.010000 1.000 1.000 1302136000 13B Currant 0.010000 1.000 1.000 1302137000 13B Currant, dried 0.010000 1.000 1.000 1302149000 13B Elderberry 0.010000 1.000 1.000 1302174000 13B Gooseberry 0.010000 1.000 1.000 1304175000 13D Grape 0.010000 1.000 1.000 1304176000 13D Grape, juice 0.010000 1.200 1.000 1304176001 13D Grape, juice

- babyfood 0.010000 1.20 0 1.000 1304179000 13D Grape, wine and sherry 0.010000 1.000 1.000 1302191000 13B Huckleberry 0.010000 1.000 1.000 1301208000 13A Loganberry 0.010000 1.000 1.000 1301320000 13A Raspberry 0.010000 1.000 1.000 1301321000 13A Raspberry, juice 0.010000 1.000 1.000 1301321001 13A Raspberry, juice

- babyfood 0.010000 1.000 1.000 1301320001 13A Raspberry

- babyfood 0.010000 1.000 1.000 1400003000 14 Almond 0.010000 1.000 1.000 1400004000 14 Almond, oil 0.010000 1.000 1.000 1400004001 14 Almond, oil

- babyfood 0.010000 1. 000 1.000 1400003001 14 Almond

- babyfood 0.010000 1.000 1.000Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 418154

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Page 10 of 12 1400059000 14 Brazil nut 0.010000 1.000 1.000 1400068000 14 Butternut 0.010000 1.000 1.000 1400081000 1 4 Cashew 0.010000 1.000 1.000 1400092000 14 Chestnut 0.010000 1.000 1.000 1400155000 14 Hazelnut 0.010000 1.000 1.000 1400156000 14 Hazelnut, oil 0.010000 1.000 1.000 1400185000 14 Hickory nut 0.010000 1.000 1.000 1400213000 14 Macadamia nut 0.010000 1.000 1.000 1400269000 14 Pecan 0.010000 1.000 1.000 1400278000 14 Pine nut 0.010000 1.000 1.000 1400282000 14 Pistachio 0.010000 1.000 1.000 1400391000 14 Walnut 0.010000 1.000 1.000 1500122000 15 Corn, field, bran 0.100000 1.000 1.000 1500120000 15 Corn, field, flour 0.100000 1.000 1.000 1500120001 15 Corn, field, flour

- babyfood 0.100000 1.000 1.000 1500121000 15 Corn, field, meal 0.100000 1.000 1.000 1500121001 15 Corn, field, meal

- babyfood 0.100000 1.000 1.000 1500125000 15 Corn, field, oil 0.100000 1.000 1.000 1500125001 15 Corn, field, oil

- babyfood 0.100000 1.000 1.000 1500123000 15 Corn, field, starch 0.100000 1.000 1.000 1500123001 15 Corn, field, starch

- babyfood 0.100000 1.000 1.000 1500124000 15 Corn, field, syrup 0.100000 1.500 1.000 15001240 01 15 Corn, field, syrup

- babyfood 0.100000 1.500 1.000 1500344000 15 Sorghum, grain 0.010000 1.000 1.000 1500345000 15 Sorghum, syrup 0.010000 1.000 1.000 8601000000 86A Water, direct, al l sources 0.019700 1.000 1.000 8602000000 86B Water, indirect, all sources 0.019700 1.000 1.000Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 418154

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### Attachment 2

. Chronic Food and Water Output File

U.S. EPA Ver. 3.16, 03

- 08

- d DEEM

- FCID Chronic analysis for RIMSULFURON NHANES 2003

- 2008 2

- day Residue file name: C: \ Documents and Settings \ MNEGUSSI \ My Documents \ DEEM Version 3.16 \ Rimsulfuron \ Chronic_Rimsulfuron2013.R08 Adjustment factor #2 NOT used. Analysis Date 03

- 17

- 2014/10:25:24 Residue file dated: 03

- 17

- 2014/10:22:42 Reference dose (RfD, Chronic) = .118 mg/kg bw/day COMMENT 1: Use on sorghum

=========================================== ==================================== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.000807 0.7% Hispanic 0.000869 0.7% Non

- Hisp

- White 0.000802 0.7% Non

- Hisp

- Black 0.000753 0.6% Non

- Hisp

- Other 0.000843 0.7% Nursing Infants 0.000659 0.6% Non

- Nursing Infants 0.002179 1.8% Female 13+ PREG 0.000756 0.6% Children 1

- 6 0.001508 1.3% Children 7

- 12 0.000952 0.8% Male 13

- 19 0.000753 0.6% Female 13

- 19/NP 0.000694 0.6% Male 20+ 0.000707 0.6% Female 20+/NP 0.000700 0.6% Seniors 55+ 0.000637 0.5% All Infants 0.001710 1.4% Female 13

- 50 0.000723 0.6% Children 1

- 2 0.001658 1.4% Children 3

- 5 0.001473 1.2% Children 6

- 12 0.001002 0.8% Youth 13

- 19 0.000724 0.6% Adults 20

- 49 0.000743 0.6% Adults 50

- 99 0.000652 0.6% Female 13

- 49 0.0007 24 0.6%

-------------------------------------------------------------------------------Rimsulfuron Dietary Exposure and Risk Assessment DP Number: 418154

PC Code: 129009

____________________________________________________________________________________________

Page 12 of 12 

### Attachment 3

. Chronic Food o nly Output File

U.S. EPA Ver. 3.16, 03

- 08

- d DEEM

- FC ID Chronic analysis for RIMSULFURON NHANES 2003

- 2008 2

- day Residue file name: C: \ Documents and Settings \ MNEGUSSI \ My Documents \ DEEM Version 3.16 \ Rimsulfuron \ ChronicFoodAlone_Rimsulfuron2013.R08 Adjustment factor #2 NOT used. Analysis Date 03

- 17

- 2014/10:42:47 Residue file dated: 03

- 04

- 2014/13:44:02 Reference dose (RfD, Chronic) = .118 mg/kg bw/day COMMENT 1: Use on sorghum

===================================================================== ========== Total exposure by population subgroup

-------------------------------------------------------------------------------

Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- --- ------------- Total US Population 0.000395 0.3% Hispanic 0.000475 0.4% Non

- Hisp

- White 0.000378 0.3% Non

- Hisp

- Black 0.000413 0.3% Non

- Hisp

- Other 0.000367 0.3% Nursing Infants 0.000286 0.2% Non

- Nursing Infants 0.000807 0.7% Female 13+ PREG 0.000368 0.3% Children 1

- 6 0.000980 0.8% Children 7

- 12 0.000608 0.5% Male 13

- 19 0.000470 0.4% Female 13

- 19/NP 0.000376 0.3% Male 20+ 0.000323 0.3% Female 20+/NP 0.00 0267 0.2% Seniors 55+ 0.000238 0.2% All Infants 0.000646 0.5% Female 13

- 50 0.000313 0.3% Children 1

- 2 0.001063 0.9% Children 3

- 5 0.000971 0.8% Children 6

- 12 0.000640 0.5% Youth 13

- 19 0.000423 0.4% Adults 20

- 49 0.000331 0.3% Adults 50

- 99 0.000245 0.2% Female 13

- 49 0.000314 0.3%

- ------------------------------------------------------------------------------