##### 



Addendum 1
to
LICENSE AND SUPPLY AGREEMENT
 th st
 th st
 8.2. Final Product
Price 8.3. Payment th
 8. Prices and Terms
 8.2.
    
    Final Product Prices
     divided  less  times




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divided  less   times  minus
  8.3.
    
    Payment
    th
 HAMELN PHARMA PLUS GMBH
    
    
    
    AKORN, INCBy:
    
    /s/ Stefan Gliwitzki
    
    
    
    By:
    
    /s/ Arthur S. PrzybylName:
    
    STEFAN GLIWITZKI
    
    
    
    Name:
    
    ARTHUR S. PRZYBYLTitle:
    
    Managing Director
    
    
    
    Title:
    
    Pres + CEOBy:
    
    /s/ Jens Borner
    
    
    
    By:
    
    /s/ ABU ALAMName:
    
    JENS BORNER
    
    
    
    Name:
    
    ABU ALAMTitle:
    
    Marketing Manager
    
    
    
    Title:
    
    svp business development




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##### 



ADDENDUM 1 to the LICENSE AND SUPPLY AGREEMENT of 11th November 2004
between HAMELN PHARMACETICALS GMBH and AKORN INC.
 Appendix D
 Example for calculation of Final Product Price
 Valid
as of October 1st 2006
 A given Quarter
 1.
Delivery to AKORN in Quarter
 Units delivered
    
    
    5.000Initial Transfer Price per unit
    
    $
    50.00Invoice to AKORN
    
    $
    250.000,00
 2.
Single large by AKORN to the market in given Quarter
 Number of units invoiced
    
    
    4.000Total Gross Sales Price
    
    $
    2.000.000,00
 3. Aggregate sales by AKORN to the market in given Quarter
 Number of units invoiced
    
    
    4.200Total Gross Sales Price
    
    $
    2.100.000,00
 4. Formula for calculating Final Product Price for single large
sales transactions in excess of $250.000,00
 Total Gross Sales Price of single transaction divided by two
    
    
    ($2.000.000,00 /2)=
    
    
    $
    1.000.000,00lessthe number
of Products invoiced from HAMELN to AKORN for this
transaction
    
    
    (4.000 * $50,00 ) =
    
    
    $
    200.000,00times the then applicable Initial Transfer PriceEquals
    
    
    
    
    
    $
    800.000,00$800.000,00
are to be paid by AKORN to HAMELN within 5 days of receiving
payments from customers
 4. Formula for calculating Final Product Price for
aggregate sales in Quarter
 Total Gross Sales Price in quarter divided by two
    
    
    ($2.100.000,00 /2)=
    
    
    $
    1.050.000,00lessthe number of Products invoiced from HAMELN to AKORN
for sales transactions to market in quarter times the
then applicable Initial Transfer Price
    
    
    (4.200 * $50,00)=
    
    
    $
    210.000,00Equals
    
    
    
    
    
    $
    840.000,00minus sum transferred for single transactions in
excess of $250,000.00 in this quarter
    
    
    
    
    
    $
    800.000,00Equals
Total
    
    
    
    
    
    $
    40.000,00$40.000,00 are to be paid by AKORN to HAMELN
within 30 days after close of the quarter
 5. Total payments from AKORN
to HAMELN in Quarter
    
    $
    800.000,00
    
    for large single transactions in excess of $250,000.00$
    40.000,00
    
    for remaining sales activities in Quarter$
    840.000,00
    
    Grandtotal
 HAMELN PHARMA PLUS GMBH
    
    
    
    AKORN, INCBy:
    
    /s/ Stefan Gliwitzki
    
    
    
    By:
    
    /s/ Arthur S. PrzybylName:
    
    STEFAN GLIWITZKI
    
    
    
    Name:
    
    ARTHUR S. PRZYBYLTitle:
    
    Managing Director
    
    
    
    Title:
    
    Pres + CEOBy:
    
    /s/ Jens Borner
    
    
    
    By:
    
    /s/ ABU ALAMName:
    
    JENS BORNER
    
    
    
    Name:
    
    ABU ALAMTitle:
    
    Marketing Manager
    
    
    
    Title:
    
    svp business development




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##### 



Appendix B-2
Product List
 st
 Shelf Life
    
    
    
    Initial Transfer PriceProduct /Strength
    
    Presentation
    
    (years)
    
    one Unit
    
    (US Dollar) per UnitCa-DTPA 
200mg/ml 
10x5ml
    
    Ampoule
    
    
    10
    
    
    10 ampoules
per pack
    
    $50 per packZn-DTPA 
200mg/ml 
10x5ml
    
    Ampoule
    
    
    10
    
    
    10 ampoules
per pack
    
    $50 perpack
 HAMELN PHARMA PLUS GMBH
 HAMELN PHARMA PLUS GMBH
    
    
    
    AKORN, INCBy:
    
    /s/ Stefan Gliwitzki
    
    
    
    By:
    
    /s/ Arthur S. PrzybylName:
    
    STEFAN GLIWITZKI
    
    
    
    Name:
    
    ARTHUR S. PRZYBYLTitle:
    
    Managing Director
    
    
    
    Title:
    
    Pres + CEOBy:
    
    /s/ Jens Borner
    
    
    
    By:
    
    /s/ Abu AlamName:
    
    JENS BORNER
    
    
    
    Name:
    
    ABU ALAMTitle:
    
    Marketing Manager
    
    
    
    Title:
    
    svp business development