SAT Report

PMN Number: P-15-0098

SAT Date: 12/23/2014

Print Date: 2/27/2015

Related cases: Yes

Health related cases: 

Ecotox related cases: 8.

Concern levels:

Type of Concern: Health Eco Comments

Level of Concern: 1-2 2

 Persistence Bioaccum Toxicity Comments

2 11

Exposure Based Review:

Health: No

Ecotox: Yes Exposure based testing (eco): Acute Aquatic Base Set Testing

Routes of exposure: Health: Dermal Inhalation 

Ecotox: All releases to water

Fate: ;

P2Rec Comments:

Comment: P2REC: SAT: Forward

Keywords:

 Keywords: NEURO; AQUATOX; GLOBAL WARMING; OZONE 

DEPLETION

Summary of Assessment:

 Fate:

Fate Summary: P-15-0098

FATE: Estimations for typical 

Liquid with MP < 25 C (E)

log Kow = 2.98 (E) 

S = 37.7 mg/L at 25 C (E)

VP = 27.8 torr at 25 C (E)
BP = 107 C (E)

H = 2.25E-2 (E)

log Koc = 2.38 (E)

log Fish BCF = 1.63 (E)

log Fish BAF = 1.92 (E) 

POTW removal (%) = 90 via stripping and sorption

Time for complete ultimate aerobic biodeg ≥ mo

Sorption to soils/sediments = moderate

Volatilization half-life from a standard river = 1 hrs

Volatilization half-life from a standard lake = 5 da

Atmospheric Oxidation Half-life = 360 hr via OH radical

PBT Potential: P2B1

*CEB FATE: Migration to ground water = moderate

 Health:

 Health Summary: Absorption is good all routes (analog). Concern for 

anesthesia at inhalation high doses.

 Test Data: : (-) in yeast, Salmonella, and E. Coli with and 

without activation

 (-) Salmonella with and without activation; (-) E. 

coli with and without activation; nonclastogenic in a human lymphocyte assay with and without 

activation; (-) inhalation mouse micronucleus assay; rat inhalation LC0 = 360,000 ppm, rats 

were anesthetized at this dose; rat 31-day inhalation NOEL = 10,000 ppm, anesthetic effects 

during the exposure period at 50,000 ppm; rat 13-week inhalation NOEC = 5000 ppm (M) or 

15,000 ppm (F) with anesthetic effects at 15,000 ppm (M) or 50,000 ppm (F); rat 2-year 

inhalation NOAEL = 50,000 ppm; evaluation of the same 2-year inhalation study showed no 

carcinogenic effects at doses up to 50,000 ppm; mouse 13-week inhalation NOEL = 15,000 ppm

with anesthetic effects at 50,000 ppm; rat inhalation developmental range finding NOEL = 

50,000 ppm; rat inhalation developmental NOEL = 15,000 ppm (dams, reduced feed 

consumption and reduced body weight gain) and 50,000 ppm (developmental); rabbit inhalation 

developmental range finding NOEL = 50,000 ppm; rabbit inhalation developmental NOEL = 

15,000 ppm (dams, feed consumption), 50,000 ppm (developmental); closed chamber gas uptake 

exposure of rats, mice, and hamsters, were determined and 

was identified as the major 

 Ecotox:

Test Organism Test 

Type

Test End 

Point

Predicted Measured Comments

fish 96-h LC50 11.4-34.7

daphnid 48-h LC50 7.3-20.9

green algal 96-h EC50 8.9-20.1

fish _ chronic value 1.3-3.6

daphnid _ chronic 0.99-2.4
value

algal _ chronic 

value

3.0-6.0

Sewage Sludge 3-h EC50 _

Sewage Sludge _ Chronic 

Value

_

Ecotox Values Comments: Predictions are based on SARs for SAR 

chemical class = solid with unknown mp(P); log Kow = 1.6 (P, 

; S = >1000 mg/L at 20 C (P, PMN); pH7; effective concentrations based on 100% 

active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and 

<2.0 mg/L;

Factors Values Comments

Assessment Factor 10

Concentration of Concern 

(ppb)

99

SARs

SAR Class

Ecotox Category 

Ecotox Factors Comments: 

 SAT Chair: L Keifer 564-8916