### SAT Report PMN Number: P-10-0009 SAT Date: 10/20/2009

Print Date: 3/3/2010

Related cases : Health related cases : Ecotox related cases:

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 2-3 3

Persistence Bioaccum Toxicity Comments 1 1 1 Exposure Based Review : Health: N o Ecotox: N o Routes of exposure : Health: Dermal Inhalation Ecotox: All releases to water Fate: ; Keywords : Keywords: SENS-S,L, IRR-E,S, SYSTEMIC, MUTA, ONCO, DEVEL, MALE REPRO, LIVER, KIDNEY, AQUATOX-A,C Summary of Assessment :
Fate : Fate Summary: P-10-0009 FATE: Solid with MP = 25-30 EC (M) log Kow = 3.1 (M); S = 19 mg/L at 25 EC (M) VP = 9.6E-6 torr at 25 EC (E) BP = 397 EC (E) H < 1.00E-8 (E) log Koc = 2.89 (E) log Fish BCF = 1.71 (E) log Fish BAF = 1.47 (E) POTW removal (%) = 0-90 via possible partial biodegTime for complete ultimate aerobic biodeg $ mo Sorption to soils/sediments = moderate PBT Potential: P1B1 *CEB FATE: Migration to ground water = moderate

Health : Health Summary: Expect poor absorption through the skin, moderate absorption from the lung and GI tract ( p che m ), expect reaction via all routes. Concern for skin and lung sensitization, mutagenicity, oncogenicity, developmental toxicity, male reproductive, liver, and kidney toxicity based on the and analogue test data. Also concern for skin and eye irritation and unspecified systemic toxicity ( N OEL = 3 mg/kg) based on analogue test data. Moderate high concern. Test Data: PMN: (+) Salmonella with and without activation; (+) E. coli with and without activation; (+) chromosomal aberration in CHL cells with and without activation For analogues:
: (+) Salmonella with and without activation; (+) E. coli with and without activation : (+) skin sensitization in guinea pigs : (+) skin sensitization in guinea pigs; moderate eye irritation in rabbits; moderate skin irritation in rabbits : (+) Sister chromatid exchange in Chinese hamster bone marrow cells; (+) N ucleus Anomaly Test in Chinese hamster bone marrow cells; (+) in a mouse lymphoma assay; (+) Salmonella with and without activation; (+) in Saccharomyces strain D4 with and without activation; rat 28-day oral NOEL = 3 mg/kg, effects not provided in the 8E submission : (+) Salmonella with and without activation; (+) in a mouse lymphoma assay; moderate skin irritation in rabbits; no skin sensitization in guinea pigs

Ecotox :

Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 0.90 2.7 N OEC = 1.5 daphnid 48-h LC50 4.1 0.47 N OEC = 0.33 green algal 96-h EC50 9.0 1.9 N OEC = 0.025; LOEC = 0.12 fish

_ chronic value 0.030 daphnid

_ chronic value 0.30 algal

_ chronic value 4.1 Sewage Sludge 3-h EC50

_Sewage Sludge

_ Chronic Value

_ Ecotox Values Comments: Predictions are based on SARs for ; SAR chemical class = MW 297; solid with mp = 30 C (M); log Kow = 3.1 (M) S = 19 mg/L at 25 C (M); p H7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L; This PMN was accompanied by ecotoxicity studies from the submitter . These studies were reviewed and conclusions are provided below. Complete details are provided in the attached spreadsheet.
The three tests are considered valid. This PMN, , was tested at nominal concentrations that were verified analytically. Tested concentrations were marginally lower than the estimated water solubility limit of 19 mg/L and the measured concentrations were generally within 75 - 105% of nominals. Daphnia is the most sensitive species with a measured 48 hour EC50 of 0.47 mg/L. To derive the COC, this value may be divided by 10 (default acute to chronic ratio for algae) to simulate a chronic toxicity concentration of 0.047 mg/L. This latter value is divided by an assessment (uncertainty) factor of 10 to yield a COC of 0.0047 mg/L or 5 μg/L ( p pb). This value replaces the COC of 3 p pb estimated from ECOSA R

- p redicted toxicity. This PMN is of high concern for aquatic toxicity.

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 5 ECOSAR predicted 3 p pb

SARs SAR Class

Ecotox Factors Comments:
SAT Chair: Becky Jones