SECURITIES AND EXCHANGE COMMISSION
                     Washington, D.C. 20549

                           FORM 10-K/A
                         AMENDMENT No. 1

[X] ANNUAL REPORT PURSUANT TO SECTION 13 OR 15(d) OF THE
    SECURITIES EXCHANGE ACT OF 1934 FOR THE FISCAL YEAR ENDED
    DECEMBER 31, 2000

                  Commission File Number 1-6247

                          ALZA CORPORATION
     (Exact name of registrant as specified in its charter)

               Delaware                        77-0142070
(State or other jurisdiction of              (I.R.S.Employer
incorporation  of organization)             Identification No.)

1900 Charleston Road, P.O. Box 7210, Mountain View, CA 94039-7210
(Address of principal executive offices)          (Zip Code)

Registrant's telephone number, including area code: (650) 564-5000

Securities registered pursuant to Section 12(b) of the Act:

                                          Name of each exchange
Title of each class                       on which registered

Common Stock                              New York Stock Exchange

5 1/4% Liquid Yield Option-trademark-     New York Stock Exchange
  Notes due 2014 (Zero Coupon-Subordinated)


     Indicate by check mark whether the registrant (1) has filed
all reports required to be filed by Section 13 or 15(d) of the
Securities Exchange Act of 1934 during the preceding 12 months
(or for such shorter period that the registrant was required to
file such reports), and (2) has been subject to such filing
requirements for the past 90 days: Yes [X] No [  ]

     Indicate by check mark if disclosure of delinquent filers
pursuant to Item 405 of Regulation S-K is not contained herein,
and will not be contained, to the best of registrant's knowledge,
in definitive proxy or information statements incorporated by
reference in Part III of this Form 10-K or any amendment to this
Form 10-K.[_]

     State the aggregate market value of the voting stock held by
non-affiliates of the registrant, as of March 1, 2001:
$9,089,328,452

     Indicate the number of shares outstanding of each of the
registrant's classes of common stock, as of March 1, 2001:

     Title of Class                     Number of Shares
     Common Stock                       238,508,480

               DOCUMENTS INCORPORATED BY REFERENCE

     Part I, Item 1 (with respect to financial information of
operating segments) and Part II, Items 5, 6, 7, 7A and 8 are
incorporated by reference to the 2000 Annual Report to
Stockholders.  Part III, Items 10, 11, 12 and 13 are incorporated
by reference to the definitive proxy statement for the
registrant's Annual Meeting of Stockholders to be held on May 3,
2001.


           ALZA CORPORATION FORM 10-K/A ANNUAL REPORT
           FOR THE FISCAL YEAR ENDED DECEMBER 31, 2000

                           TABLE OF CONTENTS

                                                             Page

Part IV.

Item 14. EXHIBITS, FINANCIAL STATEMENT SCHEDULES,
         AND REPORTS ON FORM 8-K                                3

         SIGNATURES                                             6

         EXHIBIT INDEX                                          8


                            PART IV

Item 14.  EXHIBITS, FINANCIAL STATEMENT SCHEDULES, AND REPORTS ON
          FORM 8-K

(a)  Documents filed as part of this Annual Report on Form 10-K:


     3.   Exhibits:

                3.1  Restated Certificate of Incorporation
                of ALZA Corporation filed with the Delaware
                Secretary of State on February 14, 1994 (1)

                3.2 Composite Bylaws of ALZA Corporation as
                restated on February 10, 1994 and amended on
                August 11, 1994, February 16, 1995, February 15,
                1996, August 13, 1996, February 10, 1998 and
                March 17, 1999 (2)

                3.3 Certificate of Amendment of Restated
                Certificate of Incorporation of ALZA
                Corporation, filed with the Delaware Secretary
                of State on November 1, 2000 (12)

                4.1 Indenture dated July 7, 1994 between ALZA
                Corporation and the Chase Manhattan Bank, N.A.
                as Trustee, relating to ALZA's 5 1/4% Liquid
                Yield Option-trademark- Notes (3)

                4.2 Specimen of LYONs-trademark- Certificate
                (included in Exhibit 4.1)

                4.3 Rights Agreement between ALZA Corporation
                and BankBoston, N.A., as Rights Agent (5)

                4.4  Form of Right Certificate (included in
                Exhibit 4.6)

                4.5 Indenture dated July 28, 2000 by and
                between ALZA Corporation and the Chase Manhattan
                Bank and Trust Company, N.A., as Trustee,
                relating to ALZA's Zero Coupon Convertible
                Subordinated Debentures (4)

                4.6 Registration Rights Agreement, dated July
                24, 2000, by and between ALZA Corporation,
                Credit Suisse First Boston Corporation, Chase
                Securities Inc. and Morgan Stanley & Co.
                Incorporated (4)

                10.1 Amended and Restated Executive
                Deferral Plan II (6)*

                10.2 Executive Deferral Plan II for Chief
                Executive Officer(7)*

                10.3 Amendment No. 1998-1 to Executive
                Deferral Plan II (11)*

                10.4 Amendment No. 1999-1 to Executive
                Deferral Plan II (11)*

                10.5 Amendment No. 1999-2 to Executive
                Deferral Plan II (11)*

                10.6 ALZA Corporation Amended and Restated
                Stock Plan (as amended through May 6, 1999)(8)*

                10.7 Amendment No. 1 to ALZA Corporation
                Amended and Restated Stock Plan (11)*

                10.8 Form of Executive Agreement between
                ALZA Corporation and Certain Executive Officers
                (9)*

                10.9 Form of Amendment to Executive
                Agreement between ALZA Corporation and Certain
                Executive Officers(10)*

                10.10 Executive Agreement between ALZA Corporation
                and Dr. Ernest Mario (8)*

                10.11 Supplemental ALZA Corporation Retirement
                Plan(11)*

                10.12 Form of Executive Estate Protection Plan
                Agreement(11)*

                10.13 Form of Executive Estate Protection Plan
                Collateral Agreement (11)*

                10.14 Lease Agreement between ALZA and
                P/A Charleston Road LLC for Building One of
                Charleston Road Development Project (a
                substantially identical lease is in effect for
                each of two other office buildings)(6)

                10.15 Construction Agreement between ALZA and P/A
                Charleston Road LLC relating to three office
                building lease agreements (6)

                10.16 Ground Lease between ALZA and the Peery and
                Arrillaga Trusts relating to a seven-acre parcel
                in Mountain View (6)

                10.17 Amendment No. 2000-1 to Executive Deferral
                Plan I*

                10.18 Amendment No. 2000-2 to Executive Deferral
                Plan I*

                10.19 Amendment No. 2000-1 to Executive Deferral
                Plan II*

                10.20 Amendment No. 2000-2 to Executive Deferral
                Plan II*

                13 Portions of Annual Report to Stockholders
                incorporated by reference into Annual Report on
                Form 10-K (12)

                21 Subsidiaries (12)

                23 Consent of Ernst & Young LLP, Independent
                Auditors (12)
_________________________________________________________________

Footnotes to pages 3 and 4
(1)  Incorporated by reference to ALZA's Form 10-K Annual Report
     for the year ended December 31, 1993.
(2)  Incorporated by reference to ALZA's Form 10-Q Quarterly
     Report for the quarter ended March 31, 1999.
(3)  Incorporated by reference to ALZA's Form 10-Q Quarterly
     Report for the quarter ended June 30, 1994.
(4)  Incorporated by reference to ALZA's Form S-3 Registration
     Statement (Commission File No. 333-46496) dated September
     25, 2000, as amended.
(5)  Incorporated by reference to ALZA's Form 8-K Current Report
     filed December 21, 1999.
(6)  Incorporated by reference to ALZA's Form 10-K Annual Report
     for the year ended December 31, 1997.
(7)  Incorporated by reference to ALZA's Form 10-Q Quarterly
     Report for the quarter ended September 30, 1993.
(8)  Incorporated by reference to ALZA's Form 10-Q Quarterly
     Report for the quarter ended June 30, 1999.
(9)  Incorporated by reference to ALZA's Form 10-K Annual Report
     for the year ended December 31, 1995.
(10) Incorporated by reference to ALZA's Form 10-Q/A Quarterly
     Report for the quarter ended June 30, 1999.
(11) Incorporated by reference to ALZA's Form 10-K Annual Report
     for the year ended December 31, 1999.
(12) Incorporated by reference to ALZA's Form 10-K Annual Report
     for the year ended December 31, 2000.

*A management contract or compensatory plan or arrangement
 required to be filed as an Exhibit pursuant to Item 14(c) of
 Form 10-K.






                           SIGNATURES

     Pursuant to the requirements of Section 13 or 15(d) of the
Securities Exchange Act of 1934, the registrant has duly caused
this report to be signed on its behalf by the undersigned,
thereunto duly authorized.



                                       ALZA CORPORATION



                                   By   /s/ Matthew K. Fust
                                           Matthew K. Fust
                                        Senior Vice President,
                                       Chief Financial Officer and
                                      Principal Accounting Officer







Date:   April 17, 2001

                           SIGNATURES

     Pursuant to the requirements of the Securities Exchange Act
of 1934, this report has been signed below by the following
persons on behalf of the registrant and in the capacities and on
the dates indicated.



/s/ Dr. Ernest Mario
Dr. Ernest Mario
Chairman of the Board of
Directors, Director and
Chief Executive Officer
Date: April 17, 2001


/s/ Dr. William R. Brody*               /s/ Dean O. Morton*
Dr. William R. Brody                    Dean O. Morton
Director                                Director
Date: April 17, 2001                    Date: April 17, 2001


/s/ Dr. Robert J. Glaser*               /s/ Denise M. O'Leary*
Dr. Robert J. Glaser                    Denise M. O'Leary
Director                                Director
Date: April 17, 2001                    Date: April 17, 2001


/s/ Dr. I. Craig Henderson*             /s/ Julian N. Stern*
Dr. I. Craig Henderson                  Julian N. Stern
Director                                Director
Date: April 17, 2001                    Date: April 17, 2001


/s/ Jerry T. Jackson*
Jerry T. Jackson
Director
Date: April 17, 2001




*By: Matthew K. Fust
Matthew K. Fust
Attorney-in-fact
Date: April 17, 2001




                          EXHIBIT INDEX


Exhibit

10.17     Amendment No. 2000-1 to Executive Deferral Plan I

10.18     Amendment No. 2000-2 to Executive Deferral Plan I

10.19     Amendment No. 2000-1 to Executive Deferral Plan II

10.20     Amendment No. 2000-2 to Executive Deferral Plan II




_______________________________