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United States Chemical Safety June 2010 

 Environmental Protection and Pollution Prevention 

 Agency (7510P) 

 

Chlorine Gas 

Summary Document: Registration 

Review 

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TABLE OF CONTENTS 

Chlorine Gas Registration Review Team ....................................................................... 4 

I. PRELIMINARY WORK PLAN.................................................................................. 5 

II. FACT SHEET ............................................................................................................ 16

III. GLOSSARY OF TERMS AND ABBREVIATIONS...................................21 

IV. APPENDIX A............................................................................................................ 23 
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Chlorine Gas Registration Review Team

Human Health & Environmental Effects

Tim McMahon 

Srinivas Gowda 

Risk Management

Monisha Harris 

Lance Wormell 

Office of General Counsel

Philip Ross 
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I. PRELIMINARY WORK PLAN 

Introduction

The Food Quality Protection Act (FQPA) of 1996 mandated a registration review 

program. All pesticides distributed or sold in the United States generally must be 

registered by the U.S. Environmental Protection Agency (USEPA, EPA, or the Agency), 

based on scientific data showing that they will not cause unreasonable risks to human 

health or the environment when used as directed on product labeling. The registration 

review program is intended to make sure that, as the ability to assess risk evolves and as 

policies and practices change, all registered pesticides continue to meet the statutory 

standard of no unreasonable adverse effects to human health or the environment. 

Changes in science, public policy, and pesticide use practices will occur over time. 

Through the registration review program, the Agency periodically reevaluates pesticides 

to make sure that as change occurs, products in the marketplace can be used safely. 

Information on this program is provided at 

http://www.epa.gov/oppsrrd1/registration_review/. 

The Agency is implementing the registration review program pursuant to Section 

3(g) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review 

each registered pesticide every 15 years to determine whether it continues to meet the 

FIFRA standard for registration. The Agency will consider benefits information and data 

as required by FIFRA. The public phase of registration review begins when the initial 

docket is opened for each case. The docket is the Agency’s opportunity to state what it 

knows about the pesticide and what additional risk analyses and data or information it 

believes are needed to make a registration review decision. After reviewing and 

responding to comments and data received in the docket during this initial comment 

period, the Agency will develop and commit to a final work plan and schedule for the 

registration review of chlorine gas. 

Chlorine gas, PC Code 020501, was first registered in the United States in 1948. 

Currently there are 43 active chlorine gas products registered for pesticidal use; each 

product lists chlorine at 99.5% active ingredient. The major use sites for chlorine gas 

include commercial and industrial cooling towers (once-through and recirculating), 

municipal water supplies and treatment plants, sewage and wastewater management 

plants, pulp and paper mills, commercial and industrial swimming pools, agricultural 

irrigation systems, and public water systems. Chlorine gas is also used as a chemical 

reactant in the synthesis of chlorinated inorganic chemicals such as sodium and lithium 

hypochlorite. These hypochlorite salts also have registered pesticidal uses including uses 

on terrestrial food crops (for which tolerance exemptions are listed in 40 CFR 180.1235 

and 40 CFR 180.1054) as well as several other uses including swimming pool use. The 

Agency published Reregistration Eligibility Decision documents (REDs) for sodium and 

calcium hypochlorite in 1992 and for lithium hypochlorite in 1993 that included 

assessment of all registered uses for these hypochlorite salts. 
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The Agency issued a Reregistration Eligibility Decision (RED) document for 

chlorine February 1999. The RED can be located at: 

http://www.epa.gov/pesticides/reregistration/status.htm. 

Risk Assessment Status & Anticipated Risk Assessment and Data Needs

Human Health Risk Assessment Status

The Agency has reviewed all the available information on toxicology and human 

exposure regarding chlorine gas. The toxicology and exposure databases for chlorine gas 

are considered adequate. Therefore, the Agency anticipates that no additional toxicity or 

exposure data will be needed for the chlorine gas registration review case. 

Further human health information is available in the document titled “Chlorine 

Gas: Human Health Effects Scoping Document for the Registration Review Decision,” 

dated June 4, 2010. 

Dietary and Drinking Water Exposure and Risk

Dietary Food Exposure

Food exposure to chlorine gas and aqueous chlorine is not expected to occur 

because there is not a reasonable expectation that residues significantly above naturally 

occurring background levels would occur. Due to the high reactivity and water solubility 

of chlorine and chlorine salts, residues are also not expected to accumulate or 

bioaccumulate in the food chain. Therefore, a dietary food risk assessment is not 

anticipated as being needed for chlorine gas in support of this registration review. 

Dietary Drinking Water Exposure

The registered uses of chlorine gas and aqueous chlorine include disinfection of 

municipal drinking water. The EPA's Office of Water has conducted a risk assessment 

for the use of chlorine in disinfection of municipal drinking water as well as disinfection 

byproducts resulting from the use of chlorine in municipal drinking water disinfection 

(Stage 1 Disinfectants and Disinfection Byproducts Rule (Stage 1 DBPR: 63 FR 69390 - 

69476, December 16, 1998, Vol. 63, No. 241). As a result of this assessment, a 

Maximum Residual Disinfectant Level of 4 mg/L for chlorine in municipal drinking 

water was determined as a safe level for human exposure 

(http://www.epa.gov/safewater/mdbp/dbp1.html). Maximum contaminant levels of 

disinfection byproducts were also established as a result of this assessment. As the other 

registered uses of chlorine gas/aqueous chlorine are not likely to result in contamination 

of surface or groundwater, and as the EPA's Office of Water has already assessed the 

drinking water use, the Office of Pesticide Programs does not anticipate conducting a 

drinking water assessment for chlorine gas/aqueous chlorine. 
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Tolerances

There is a tolerance exemption for chlorine gas (40 CFR 180.1095) “when used 

preharvest or postharvest in solution on all raw agricultural commodities.” There are also 

tolerance exemptions for both sodium hypochlorite (40CFR 180.1235) and calcium 

hypochlorite (40CFR 180.1054). 

Aggregate and Cumulative Exposure and Risk

In examining aggregate risk, the Agency takes into account the available and 

reliable information concerning exposures to pesticide residues in food, drinking water, 

and non-occupational pesticide exposures. For the registered uses of chlorine gas, there 

is no expectation that residues above background levels will occur to chlorine in the diet 

from food contact or food uses. Therefore, there is no expectation that exposure in the 

diet from food contact or food uses of chlorine gas will result in an exposure that would 

be considered in an aggregate risk assessment, because this level would be no different 

than background levels that humans are exposed to on a daily basis. With respect to the 

disinfection of municipal drinking water, a maximum residual disinfectant level of 4mg/L 

for chlorine residue has been established by the Agency’s Office of Water which has 

been determined to be a safe level for human exposure. Therefore, this exposure would 

not contribute to an increased aggregate risk, as it has already been pointed out that there 

is no increased dietary exposure over background, and the drinking water disinfectant 

level of 4 mg/L for chlorine had been determined to be a safe level for human exposure. 

Together then, dietary and drinking water exposures do not contribute to an increased 

risk. Non-dietary residential dermal and incidental oral exposures could result from use 

of chlorine gas in swimming pools. The Agency will need to consider the magnitude of 

these exposures, the health effects that have been reported from dermal and incidental 

oral exposures to chlorine, the dose levels at which these effects have been reported, and 

the relationship of these effects to actual human exposures to determine whether an 

aggregate assessment is appropriate. It should be noted that use of proper application 

methods and use of trained personnel in the use of chlorine gas would likely result in 

minimal to no exposure from this use. 

Section 408(b)(2)(D)(v) of FFDCA requires that, when considering whether to 

establish, modify, or revoke a tolerance, the Agency consider “available information” 

concerning the cumulative effects of a particular pesticide's residues and “other 

substances that have a common mechanism of toxicity.” EPA has not yet determined 

whether chlorine gas has a common mechanism with other compounds; consequently, a 

cumulative assessment will not be performed at this time. 

Occupational and Residential Exposure and Risk

An occupational and/or residential exposure assessment is required for an active 

ingredient if (1) certain toxicological criteria are triggered and (2) there is potential 

exposure to handlers (mixers, loaders, applicators, etc.) during use or to persons entering 

treated sites after application is complete. Because chlorine gas is metered into water 
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through closed systems in manufacturing processes or from large stationary containers 

such as tank cars, tank trucks, and cylinders, the Agency believes that occupational and 

post-application exposure to chlorine gas, including exposure of pool service operators 

and bystanders is not significant provided proper application methods are followed. 

These application methods are presented in pamphlets published by the Chlorine 

Institute, available at: 

http://www.chlorineinstitute.org/Bookstore/content.cfm?ItemNumber=3637&navItemNu

mber=3638). 

Anticipated Physical/Chemical Property Data Needs

All product chemistry data requirements have been fulfilled for chlorine gas. 

Therefore, it is anticipated that additional product chemistry data will not be needed for 

the active ingredient chlorine gas. 

Further information is available in the “Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the Chlorine Gas Registration Review 

Decision Document,” dated June 3, 2010. 

Environmental Fate and Ecological Risk Assessment and Data Needs

The Agency has reviewed the environmental fate and ecological hazard databases 

for chlorine gas. Based on its review, EPA believes risk assessments are needed to ensure 

that the chlorine gas registration review case meets FIFRA standards. The Agency will 

complete the environmental fate and ecological hazard risk assessments presented below. 

• Environmental Fate 

• Ecological hazard 

• Endangered species assessment 

Further information is available in the “Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the Chlorine Gas Registration Review 

Decision Document,” dated June 3, 2010. 

The Agency needs to conduct ecological risk assessments for chlorine used in 

once-through water cooling towers for control of microbiological growth and that likely 

would be discharged into effluents and surface waters. Therefore, the Agency anticipates 

needing ecotoxicity data for chlorine that is of potential concern for once-through water 

cooling towers uses of chlorine. The following ecotoxicity data are needed to conduct an 

ecological risk assessment: 

Anticipated Ecological Data Needs 

o (GLN 850.4225) seedling emergence, Tier II - dose response study on rice 

(Oryza sativa); 
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o (GLN 850.4250) vegetative vigor, Tier II - dose response study on rice 

(Oryza sativa); 

o (GLN 850.4400) aquatic plant growth (aquatic vascular plant toxicity), 

Tier II - dose response study on floating macrophyte Lemna gibba; and 

o (GLN 850.5400) aquatic plant growth (algal toxicity), Tier II - dose 

response studies on (Selenastrum capricornutum (green algae), Anabaena 

flos- aquae (blue-green cyanobacteria), Navicula pelliculosa (freshwater 

diatom), and Skeletonema costatum (marine diatom). 

Endangered Species

 The Agency has not conducted a risk assessment that supports a complete 

endangered species determination for chlorine gas. The ecological risk assessment 

planned during registration review will allow the Agency to determine whether chlorine 

gas use has “no effect” or “may affect” federally listed threatened or endangered species 

(listed species) or their designated critical habitats. When an assessment concludes that a 

pesticide’s use “may affect” a listed species or its designated critical habitat, the Agency 

will consult with the U.S. Fish and Wildlife Service and/or National Marine Fisheries 

Services (the Services), as appropriate. 

Incidents

 The toxicological review of chlorine by the Agency for Toxic Substances and 

Disease Registry (ATSDR, 2002) summarizes an extensive database regarding human 

exposure to chlorine gas by the inhalation, oral, and dermal routes of exposure. 

With respect to inhalation exposure, death from chlorine gas used as a chemical 

weapon in World War I was noted. Causes of death from this exposure were bronchopneumonia, lobar pneumonia, purulent pleurisy, and tuberculous meningitis. The 

concentration of exposure causing death was not known in this circumstance. More 

recent incidents involving exposure to chlorine gas as a result of rail car accidents in 

which chlorine gas was released also did not note actual levels producing lethality, but as 

noted in the ATSDR review, “Prater (1990) indicates that concentrations of 400 ppm can 

be lethal to humans in 30 minutes and that immediate death follows inhalation of a 

concentration of 1,000 ppm. Concentrations between 1,000 and 1,200 ppm for 30 

minutes are lethal to humans according to a review of earlier data from various American 

authors by Withers and Lees (1985b).” As might be expected, the respiratory tract is the 

primary target of inhalation exposure to chlorine gas, and toxicity resulting from such 

exposure is manifest upon the tissues and organs of the respiratory tract. 

From oral exposure, death in humans has been reported from ingestion of 200 mL 

of a solution containing 3–6% chlorine (as sodium hypochlorite) (ATSDR, 2002). 

Regarding accidental ingestion, only minor effects on the gastrointestinal tract were 

observed in data compiled by Pike et al. (1963), who reviewed 129 cases of children who 

ingested Clorox® and reported that no complications of consequences were found. Sixtyfive cases were examined by esophagoscopy within 96 hours of the ingestion and only 2 
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showed evidence of esophageal injury. The children were between 12 month and 7 years 

old and the amounts of bleach ingested ranged from “1⁄2 ounce to 1 cup (ATSDR, 2002). 

With respect to dermal exposure, the ATSDR review notes that “No studies were 

located regarding respiratory, cardiovascular, gastrointestinal, hematological, 

musculoskeletal, hepatic, renal, endocrine, and body weight effects in humans or in 

animals following dermal exposure to aqueous chlorine.” However, it is known that 

dermal exposure to chlorine is extremely irritating to skin. 

 From OPP’s Incident Data System, the following information was obtained on 

chlorine gas. The reported routes of exposure for the 324 incident cases involving 

chlorine gas-specific incidents were inhalation (99.7%), ocular (38%), and dermal (10%). 

It should be noted that in many cases, more than one route of exposure applied for an 

individual incident case (e.g., inhalation and ocular). The most common symptoms 

reported for the routes of exposure are listed below: 

• Inhalation exposure ( headache (26%), difficulty breathing/shortness of breath 

(24%), sore throat/throat irritation (22%), coughing (21%), respiratory irritation 

(14%), nausea (11%), chest pain/tightness (10%), nasal irritation (8%), 

asthma/wheezing (7%), vomiting (6%), and dizziness/lightheadedness (6%). In 

many cases more than one symptom was reported for each exposure route. 

• Ocular exposure (eye irritation/burning/pain )(100%). 

• Dermal exposure (skin irritation/burning) (100%). 

Aqueous Chlorine Related Incidents 

 The reported routes of exposure for the 17 incidence cases involving aqueous 

chlorine incidents were inhalation (59%), ingestion (29%), dermal (18%) and ocular 

(12%). It should be noted that in many cases, more than one route of exposure applied 

for an individual incident case (e.g., inhalation and dermal). The most common 

symptoms reported for the routes of exposure are listed below: 

• Inhalation exposure (difficulty breathing/shortness of breath (50%), respiratory 

irritation (30%), skin irritation/burns (30%), sore throat/throat irritation (20%), 

digestive system irritation (20%), headache (20%), coughing (20%), impaired 

cognitive ability/psychological effects (20%), nausea (6%), chest pain/tightness 

(10%), nasal irritation (10%), asthma/wheezing (10%), dizziness/lightheadedness 

(10%), and weakness (10%)). In many cases more than one symptom was 

reported for each exposure route. 

• Ingestion exposure (vomiting (100%), sore throat/throat irritation (60%), and 

digestive system irritation (20%)). 

• Dermal exposure (skin irritation/burns (100%)) 

• Ocular exposure (eye irritation/burning/pain (100%)). 
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Adverse Ecological Incidents 

The Agency maintains a database system (Ecological Incident Information System or 

EIIS) to track and evaluate accidental kills associated with pesticide use. The likelihood that 

a particular pesticide caused the incident is classified as “highly probable”, “probable”, 

“possible”, or “unlikely”, based on the information contained in the incident report. A 

review of the EIIS database for ecological incidents involving chlorine (PC Code 020501) 

was completed on 05/12/2000. A summary of the results are presented below. 

For chlorine, one incident report was filed in which unknown species of fish were 

killed in a lake upon a spill of chlorine from a water treatment plant. The number of fish 

killed were unknown. The certainty index was highly probable for the incident and a 

substantial spill of chlorine will kill fish. The report was filed in 2000. 

This incident data is consistent with the available acute toxicity data indicating that 

chlorine is very highly toxic to fish. 

Timeline

EPA has created the following estimated timeline for the completion of the chlorine gas 

registration review: 

Anticipated Schedule

Activities Estimated Month/Year

Phase 1: Opening the docket 

Open Public Comment Period for Chlorine Gas Docket June 2010 

Close Public Comment Period August 2010 

Phase 2: Case Development 

Develop Final Work Plan (FWP) November 2010 

Issue DCI November 2011 

Data Submission November 2012 

Open Public Comment Period for Preliminary Risk Assessments March 2014 

Close Public Comment Period June 2014 

Phase 3: Registration Review Decision 

Open Public Comment Period for Proposed Reg. Review Decision September 2015 

Close Public Comment Period December 2015 

Final Decision and Begin Post-Decision Follow-up 2015 

Total (years) 6 
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Guidance for Commenters

The public is invited to comment on EPA’s preliminary registration review work 

plan and rationale. The Agency will carefully consider all comments as well as any 

additional information or data provided in a timely manner prior to issuing a final work 

plan for the chlorine gas registration review case. 

Trade Irritants 

Through the registration review process, the Agency intends to solicit information 

on trade irritants and, to the extent feasible, take steps toward facilitating irritant 

resolution. Growers and other stakeholders are asked to comment on any trade irritant 

issues resulting from lack of Maximum Residue Limits (MRLs) or disparities between 

U.S. tolerances and MRLs in key export markets, providing as much specificity as 

possible regarding the nature of the concern. 

Water Quality 

Chlorine gas is not identified as a cause of impairment for any water bodies listed 

as impaired under section 303(d) of the Clean Water Act, based on information provided 

at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_grou

p_id=885. In addition, no Total Maximum Daily Loads (TMDL) have been developed 

for chlorine gas, based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detail?p_pollutant_gr

oup_id=885&p_pollutant_group_name=PESTICIDES. More information on impaired 

water bodies and TMDLs can be found at http://www.epa.gov/owow/tmdl/. The Agency 

invites submission of water quality data for this pesticide. To the extent possible, data 

should conform to the quality standards in Appendix A of the OPP Standard Operating 

Procedure: Inclusion of Impaired Water Body and Other Water Quality Data in OPP’s 

Registration Review Risk Assessment and Management Process (see: 

http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm), in order to 

ensure the data can be used quantitatively or qualitatively in pesticide risk assessments. 

Environmental Justice 

EPA seeks to achieve environmental justice, the fair treatment and meaningful 

involvement of all people, regardless of race, color, national origin, or income, in the 

development, implementation, and enforcement of environmental laws, regulations, and 

policies. To help address potential environmental justice issues, the Agency seeks 

information on any groups or segments of the population who, as a result of their 

location, cultural practices, or other factors, may have atypical, unusually high exposure 

to chlorine gas compared to the general population. Please comment if you are aware of 

any sub-populations that may have atypical, unusually high exposure compared to the 

general population. 
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Structure Activity Relationships 

EPA must rely upon information of appropriate quality and reliability for each 

decision made by the Agency. In the Office of Pesticide Programs (OPP), the evaluation 

process for a pesticide chemical traditionally begins with the applicant’s submission of a 

set of studies conducted with the specific pesticide chemical of interest. The use of the 

results of such testing (measured data) is a logical, scientifically rigorous process that 

identifies the physical, chemical, and environmental fate properties of the pesticide, as 

well as the dose and endpoints at which an adverse effect can occur in various animal 

species. 

Today, there is significant interest in alternative techniques, i.e., techniques other 

than data generation that could significantly inform the Agency’s decision-making 

process. Recently, OPP has made increasing use of structure activity relationship (SAR) 

as part of its regulatory decision-making process. In the SAR process, a chemical's 

molecular structure is compared to that of other chemicals for which data are available. 

These structural similarities are then used to make predictive judgments about a 

chemical’s physical, chemical, and biological properties. Thus, the chemical’s physical, 

chemical, and biological properties are a function of (or directly related to) the chemical’s 

molecular structure. Quantitative SAR is referred to as QSAR. To develop a QSAR, a 

selected set of measured data on a single physical, chemical, or biological property is 

used to derive a model (an equation) to predict the value of that property. 

 Since SAR assessments and QSAR modeling are another set of tools that are 

available to Agency scientists, OPP has begun a process shift that envisions shifting from 

the current study-by-study approach to an approach in which the use of predicted data, 

generated using validated models, is considered along with information from open 

literature and studies specifically generated under Part 161 requirements. All relevant 

information would be considered as part of a weight-of-the-evidence evaluation. 

At this time, EPA believes that for certain endpoints, especially physical/chemical 

and fate properties, that SAR and QSAR might be effectively utilized to fulfill these data 

requirements for many antimicrobial pesticide chemicals. When considering biological 

properties, at this time, EPA believes that SAR and QSAR can be most effectively 

utilized in the evaluation of chemicals that exhibit lower toxicity for human health and/or 

ecotoxicity parameters. This is appropriate because the risk assessment for lower toxicity 

chemicals can be stream-lined, i.e., a screening-level assessment procedure rather than 

multiple tiers of assessments with progressively more data requirements. 

If stakeholders believe that submission of predicted data can fulfill one of the data 

needs for chlorine gas, then the Agency invites submission of this information. The 

submitter would be expected to supply a rationale describing the utility of the information 

and provide documentation on the scientific validity of the information. The 

determination that the predicted data fulfills the data requirement would be at the sole 

discretion of the Agency. Pre-submission consultation with the Agency is encouraged. 
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Endocrine Disruptor Screening Program 

As required under FFDCA section 408(p), EPA has developed the Endocrine 

Disruptor Screening Program (EDSP) to determine whether certain substances (including 

pesticide active and other ingredients) may have an effect in humans or wildlife similar to 

an effect produced by a “naturally occurring estrogen, or other such endocrine effects as 

the Administrator may designate.” The EDSP employs a two-tiered approach to making 

the statutorily required determinations. Tier 1 consists of a battery of 11 screening assays 

to identify the potential of a chemical substance to interact with the estrogen, androgen, 

or thyroid (E, A, or T) hormonal systems. Chemicals that go through Tier 1 screening and 

are found to have the potential to interact with E, A, or T hormonal systems will proceed 

to the next stage of the EDSP where EPA will determine which, if any, of the Tier 2 tests 

are necessary based on the available data. Tier 2 testing is designed to identify any 

adverse endocrine related effects caused by the substance, and establish a quantitative 

relationship between the dose and the E, A, or T effect. 

Between October 2009 and February 2010, EPA issued test orders/data call-ins 

for the first group of 67 chemicals, which contains 58 pesticide active ingredients and 9 

inert ingredients. This list of chemicals was selected based on the potential for human 

exposure through pathways such as food and water, residential activity, and certain postapplication agricultural scenarios. This list should not be construed as a list of known or 

likely endocrine disruptors. 

Chlorine gas is not among the group of 58 pesticide active ingredients on the 

initial list to be screened under the EDSP. Under FFDCA sec. 408(p) the Agency must 

screen all pesticide chemicals. Accordingly, EPA anticipates issuing future EDSP 

orders/data call-ins for all Registration Review cases, including those for which EPA has 

already opened a Registration Review docket for a pesticide active ingredient. 

For further information on the status of the EDSP, the policies and procedures, the 

list of 67 chemicals, the test guidelines and the Tier 1 screening battery, please visit our 

website: http://www.epa.gov/endo/. 

Additional Information

Stakeholders are also specifically asked to provide available information and data that 

will assist the Agency in refining the risk assessments. The Agency is interested in 

receiving the following information: 

1. Confirmation on the following label information: 

a. Sites of application 

b. Formulations 

c. Application methods and equipment 

d. Maximum application rates 

e. Frequency of application, application intervals and maximum 

 number of applications 
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f. Geographic limitations on use 

2. Use or potential use distribution 

3. Use history 

4. Usage/use information for non-agricultural uses (e.g., materials preservation) 

5. Typical application interval 

6. State or local use restrictions 

7. Ecological incidents (non-target plant damage and avian, fish, reptilian, 

amphibian and mammalian mortalities) not already reported to the Agency 

8. Monitoring data 

9. Structure Activity Relationships

Next Steps

After the 60-day comment period closes in August 2010, the Agency will review 

and respond to any comments received in a timely manner, and then issue a Final Work 

Plan for chlorine gas. 
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II. FACT SHEET 

Background Information

• Active Ingredient: Chlorine Gas 

• Registration review case number: 4022 

• PC Code: 020501 

• CAS#: 7782-50-5 

• Technical registrants: The Dow Chemical Co., PPG Industries, Inc., Pioneer 

Americas, LLC, Canexus U.S., Inc., Chemical Formulators Inc., Olin 

Corporation, and Brenntag Canada, Inc. 

• First approved for use in a registered product: 1948 

• Antimicrobials Division Chemical Review Manager (CRM): Monisha Harris, 

harris.monisha@epa.gov 

• Antimicrobials Division Product Manager (PM): Wanda Henson, 

henson.wanda@epa.gov 

Chemical Identity/Structure:

Cl-Cl 

Use & Usage Information

• Chlorine gas is an antimicrobial pesticide registered for use as a disinfectant, 

sanitizer, microbiocide, microbiostat, and algaecide in a wide variety of 

applications. 

• Antimicrobial Use Sites: pulp/paper mill water systems, commercial/industrial 

recirculating water cooling systems, sewage systems, swimming pool water 

systems, ornamental ponds/aquaria, human drinking water systems, food 

processing water systems, egg handling equipment, egg plants, hatcheries, and 

brooder rooms. 

Recent Regulatory Actions

A Reregistration Eligibility Decision (RED) for chlorine gas was issued in 

February 1999. 

Human Health Risk Assessment Status

 The Agency does not anticipate requiring additional human health data for 

chlorine gas or aqueous chlorine. Uses of chlorine gas in food and food contact scenarios 

are not reasonably expected to result in residues of chlorine above background levels, and 

EPA has established a tolerance exemption for the use of chlorine gas (40 CFR 180.1095) 

“when used preharvest or postharvest in solution on all raw agricultural commodities.” 

Use of chlorine as a drinking water disinfectant has been assessed for safety by EPA's 

Office of Water, and the 4mg/L level established has been determined to be a safe level 

for human exposure. Occupational and post-application exposure from use of chlorine 

gas is not expected to result in significant exposure when use directions are followed, as 
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noted in the Chlorine Institute's published pamphlets on the safe use of chlorine gas 

(http://www.chlorineinstitute.org/Bookstore/content.cfm?ItemNumber=3637&navItemN

umber=3638) 

Further human health information is available in the document titled “Chlorine 

Gas: Human Health Effects Scoping Document for the Registration Review Decision,” 

dated June 4, 2010. 

Product Chemistry Database Status

The Agency has reviewed the product chemistry database for the chlorine gas 

registration review case and anticipates that no additional product chemistry data will be 

needed for registration review because all product chemistry data requirements have been 

satisfied. 

Further information is available in the “Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the Chlorine Gas Registration Review 

Decision Document,” dated June 3, 2010. 

Environmental Fate & Ecological Risk Assessment Status

The Agency will conduct environmental fate and ecological risk assessments for 

chlorine gas. Prior to conducting the risk assessment, the Agency anticipates requiring 

additional data. 

 The Agency has not conducted a risk assessment that supports a complete 

endangered species determination for chlorine gas. The ecological risk assessment 

planned during registration review will allow the Agency to determine whether chlorine 

gas use has “no effect” or “may affect” federally listed threatened or endangered species 

(listed species) or their designated critical habitats. When an assessment concludes that a 

pesticide’s use “may affect” a listed species or its designated critical habitat, the Agency 

will consult with the U.S. Fish and Wildlife Service and/or National Marine Fisheries 

Services (the Services), as appropriate. 

Further information is available in the “Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the Chlorine Gas Registration Review 

Decision Document,” dated June 3, 2010.

Tolerances 

Chlorine gas is exempt from the requirement of a tolerance when used pre-harvest 

or post-harvest in solution on all raw agricultural commodities (40 CFR §180.1095). 
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Data Call-In Status

 

A Generic Data Call-In (GDCI) for chlorine was issued in March 1999 (data 

requirements satisfied). A Product-Specific Data Call-In (PDCI) for chlorine was issued 

in February 1999 (data requirements satisfied). The Agency anticipates issuing a data 

call-in (DCI) for chlorine gas to support the registration review risk assessment process. 

Labels 

There are 43 registered products that contain chlorine gas. The EPA Registration 

Numbers are provided in Table 1 below. For future reference, during registration review 

a list of product registration numbers will be included in the docket. Product registration 

labels may be obtained from the Pesticide Product Label System (PPLS) website at: 

http://oaspub.epa.gov/pestlabl/ppls.home. 

Table 1. Registered Active Products of Chlorine Gas 

Registration # Registration Name Company Name Formulation 

Type 

% of 

Active 

Ingredient 

148-707 Liquid Chlorine Harcros Chemicals 

Inc. Pressurized Gas 99.5 

266-35 Hill Brothers Chlorine Hill Brothers 

Chemical Co. Pressurized Gas 99.5 

464-99 Chlorine The Dow Chemical 

Co. 

Technical 

Chemical 99.5 

550-200 Chlorine Univar USA Inc. Pressurized Gas 99.5 

748-31 Liquid Chlorine (Under 

Pressure) PPG Industries, Inc Technical Chemical 99.5 

813-10 Chlorine DPC Industries, Inc. Pressurized Gas 99.5 

935-8 Chlorine Liquified Gas Occidental Chemical 

Corporation 

Formulation 

Intermediate 99.5 

1744-10 Sunny Sol Chlorine JCI Jones Chemicals, 

Inc. Pressurized Gas 99.5 

2686-3 Liquid Chlorine Hydrite Chemical Co. Pressurized Gas 99.5 

2792-61 Decco 240 Liquid 

Chlorine 

Decco, Cerexagri, 

Inc. Pressurized Gas 99.5 

6785-1 Compressed Chlorine Gas Brenntag Mid-South, 

Inc. Pressurized Gas 99.5 

7151-4 Chlorine Alexander Chemical 

Corp Pressurized Gas 99.5 

7870-2 Chlorine Hawkins Inc. Pressurized Gas 99.5 
Docket Number: EPA-HQ-OPP-2010-0242 

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8996-6 Chlorine Liquified Gas 

Under Pressure Sierra Chemical Co. Pressurized Gas 99.5 

9768-21 Liquid Chlorine Thatcher Co. Pressurized Gas 100 

33458-1 Compressed Chlorine Gas Allied Universal 

Corp. Pressurized Gas 99.5 

35317-2 Compressed Chlorine Gas Kuehne Chemical 

Company, Inc. Pressurized Gas 99.5 

37982-2 Chlorine Gas Pioneer Americas, 

LLC Pressurized Gas 99.5 

37982-39 

Chlorine Liquefied Gas 

Under Pressure 

Manufacturing Use 

Product 

Pioneer Americas, 

LLC 

Technical 

Chemical 99.5 

41209-4 Chlorine Liquified Gas South Texas 

Chlorine, Inc. 

Pressurized 

Liquid 99.5 

43407-1 Chlorine-Liquefied Gas California Int'l 

Chemical Co, Inc. Pressurized Gas 99.5 

45849-1 Chlorine Liquified Gas 

Under Pressure Pool Chlor Inc. Technical Chemical 99.5 

45851-1 Chlorine Pool Chlor Of 

Nevada, Inc. Pressurized Gas 99.5 

50956-6 Chlorine Erco Worldwide Pressurized Gas 99.5 

52134-1 Chlorine Liquified Gas 

Under Pressure 

Pool Chlor Of 

Arizona Inc. Pressurized Gas 99.5 

52374-12 Chlorine Brenntag Southwest, 

Inc. Pressurized Gas 99.5 

56410-1 Liquefied Chlorine Gas 

Under Pressure 

Riveroaks Chemical 

Company Pressurized Gas 99.5 

56572-2 Chlorine Gas Splash Pool 

Chemicals, Inc. Pressurized Gas 99.5 

56652-1 

Chlorine Gas (Liquefied 

Under Pressure) Non 

Flammable 

Poolman Pressurized Gas 99.5 

57101-1 Chlorine Liquified Gas 

Under Pressure 

Rainbow Pool 

Service & Repair Pressurized Gas 99.5 

58618-1 Chlorine Liquefied Gas 

Under Pressure 

Sun Coast Pool 

Chemical Pressurized Gas 99.5 

58687-1 Chlorine-- Liquified Gas 

Under Pressure 

Georgia Gulf 

Chemicals And 

Vinyls, LLC 

Pressurized Gas 99.9 
Docket Number: EPA-HQ-OPP-2010-0242 

www.regulations.gov

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63802-1 Chlorine US Magnesium LLC Ready-to-Use 

Solution 99.7 

67649-5 Chlorine SG Rowell Chemical 

Corp. Pressurized Gas 99.5 

67799-1 Seachlor 100 Seaco Technologies, 

Inc. Pressurized Gas 99.5 

69874-4 Chlorine Canexus U.S., Inc. Pressurized Gas 99.9 

69874-5 Chlorine-Manufacturing 

Use Canexus U.S., Inc. Technical Chemical 99.9 

70264-1 Chlorine Altivia Corporation Solid Agar 99.5 

70529-1 Chlorine Gas Chemical 

Formulators Inc. 

Technical 

Chemical 99.5 

72315-1 Olin Chlorine Olin Corporation Technical 

Chemical 99.5 

81987-1 Chlorine Liquefied Gas 

Under Pressure 

California Water 

Services 

Ready-to-Use 

Solution 99.5 

84043-1 Liquid Chlorine Equa-Chlor, Inc. Pressurized Gas 99.9 

86027-3 Chlorine Brenntag Canada, 

Inc. 

Technical 

Chemical 99.9 
Docket Number: EPA-HQ-OPP-2010-0242 

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III. GLOSSARY of TERMS & ABBREVIATIONS

ai Active Ingredient 

AR Anticipated Residue 

ASTM American Society for Testing and Materials 

AWPA American Wood Preserver’s Association 

CFR Code of Federal Regulations 

cPAD Chronic Population Adjusted Dose 

CSF Confidential Statement of Formula 

CSFII USDA Continuing Surveys for Food Intake by Individuals 

DCI Data Call-In 

DEEM Dietary Exposure Evaluation Model 

DFR Dislodgeable Foliar Residue 

DNT Developmental Neurotoxicity 

DWLOC Drinking Water Level of Comparison 

EC Emulsifiable Concentrate Formulation 

EDWC Estimated Drinking Water Concentration 

EEC Estimated Environmental Concentration 

EPA Environmental Protection Agency 

EUP End-Use Product 

FDA Food and Drug Administration 

FIFRA Federal Insecticide, Fungicide, and Rodenticide Act 

FFDCA Federal Food, Drug, and Cosmetic Act 

FQPA Food Quality Protection Act 

FOB Functional Observation Battery 

GENEEC Tier I Surface Water Computer Model 

IR Index Reservoir 

LC50 Median Lethal Concentration. A statistically derived concentration of a 

substance that can be expected to cause death in 50% of test animals. It is 

usually expressed as the weight of substance per weight or volume of water, air 

or feed, e.g., mg/l, mg/kg or ppm. 

LD50 Median Lethal Dose. A statistically derived single dose that can be expected to 

cause death in 50% of the test animals when administered by the route indicated 

(oral, dermal, inhalation). It is expressed as a weight of substance per unit 

weight of animal, e.g., mg/kg. 

LOC Level of Concern 

LOAEL Lowest Observed Adverse Effect Level 

μg/g Micrograms Per Gram 

μg/L Micrograms Per Liter 

mg/kg/day Milligram Per Kilogram Per Day 

mg/L Milligrams Per Liter 

MOE Margin of Exposure 

MRID Master Record Identification (number). EPA's system of recording and tracking 

submitted studies. 

MUP Manufacturing-Use Product 

NA Not Applicable 

NAWQA USGS National Ambient Water Quality Assessment 

NPDES National Pollutant Discharge Elimination System 

NR Not Required 

NOAEL No Observed Adverse Effect Level 

OPP EPA Office of Pesticide Programs 

OPPTS EPA Office of Prevention, Pesticides and Toxic Substances 

PAD Population Adjusted Dose 

PAIRA Pure Active Ingredient Radiolabelled 

PCA Percent Crop Area 

PDP USDA Pesticide Data Program 
Docket Number: EPA-HQ-OPP-2010-0242 

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PHED Pesticide Handler's Exposure Data 

PHI Preharvest Interval 

ppb Parts Per Billion 

PPE Personal Protective Equipment 

ppm Parts Per Million 

PRZM/EXAMS Tier II Surface Water Computer Model 

Q1* The Carcinogenic Potential of a Compound, Quantified by the EPA's Cancer 

Risk Model 

RAC Raw Agriculture Commodity 

RED Reregistration Eligibility Decision 

REI Restricted Entry Interval 

RfD Reference Dose 

RQ Risk Quotient 

SCI-GROW Tier I Ground Water Computer Model 

SAP Science Advisory Panel 

SF Safety Factor 

SLN Special Local Need (Registrations Under Section 24©) of FIFRA) 

TGAI Technical Grade Active Ingredient 

TEP Typical End-Use Product 

USDA United States Department of Agriculture 

UF Uncertainty Factor 

WPS Worker Protection Standard 
Docket Number: EPA-HQ-OPP-2010-0242 

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IV. APPENDIX A

Use Patterns for Chlorine Gas 

Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Industrial Processes and Water Systems Municipal Water Supplies, Sewage and Wastewater Management Plants 

Pressurized Gas 266-35 8996-6 Technical Chemical 748-31 

Dispensing Equipment 

Not Listed Only specifically design

should be used in accorinstructions and accordirecommendations for dolevels which should be site of application. 

Municipal Water Supplies, Sewage and Wastewater Management Plants, Cooling Systems, Paper Mills, and Repacking Portable Cylinders 

Pressurized Gas 148-707 Technical Chemical 72315-1 

Dispensing Equipment 

Not Listed New York use only. On

dispensing equipment swith the manufacturer’s state regulatory agency or residual chlorine levefor each specific site of obtain their own registr

Municipal Water Supplies and Treatment Plants, Sewage and Wastewater Management Plants, Water Cooling Systems, Industrial and Commercial Cooling Systems, Pulp and Paper Mills and Repackaging into Portable Cylinders 

Pressurized Gas 5382-38 35317-2 50956-6 Technical Chemical 41209-4 Ready to Use 63802-1 Solid Agar 

Dispensing Equipment 

Not Listed Only specifically design

should be used in accorinstructions and accordirecommendations for dolevels which should be site of application. Re-pregistration with the EP
Docket Number: EPA-HQ-OPP-2010-0242 

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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

70264-1 Pressurized Gas 7870-2 

Dispensing Equipment 

Refer to the appropriate Chlorine Institute Pamphlet for instructions on the required product use and safety procedures. 

Never tamper with fusibrepair cylinders, tons or dispensing equipment, maccordance with the praapplicable product labelChlorine Institute Pamp

Municipal Water Supplies, Sewage and Wastewater Management Plants, Water Cooling Systems and Paper Mills 

Pressurized Gas 58687-1 

Dispensing Equipment 

Not Listed Only specifically design

should be used in accorinstructions and accordirecommendations for dolevels which should be site of application. This product cannot be cylinders. Pool service cylinders must obtain thEPA. 

Municipal Water Supplies, Sewage and Wastewater Management Plants, Used in Production of Bleach, Plastics, Chlorinated Solvents, Refrigerants and Intermediates for Products Containing no Chlorine 

Formulation Intermediate 935-8 

Dispensing Equipment 

Not Listed Provide special training 

Protect from physical dinspect piping and contaservice. Liquid levels shcapacity. Use in well ve

Municipal Water Supplies, Sewage and Waste Management Plants , Recirculating Cooling Water in Industrial Cooling Systems, Paper Mills and Other Industrial Applications 

Pressurized Gas 550-200 6785-1 

Dispensing Equipment 

Refer to the Chlorine Manual published by the Chlorine Institute for instructions on the required product use and procedures. 

Connection of containermanifold is not recommmanifold a new containtemperature as other cosystem. 
Docket Number: EPA-HQ-OPP-2010-0242 

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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Municipal Water Supplies, Sewage and Waste Management Plants , Recirculating Cooling Water in Industrial Cooling Systems, Paper Mills and Other Industrial Applications (Continued) 

Pressurized Gas 550-200 6785-1 

Dispensing Equipment 

Using Chlorine in Containers (See Diagrams 1-4) Connecting and Disconnecting: Use 500 Psig Copper Tubing filtered with special adapter (4-A Cylinder 4-B for Ton Container) to connect container to piping system. To connect line to container remove valve protection hood. (1) Check to ensure cylinder valve is closed: valve closes clockwise. Adjust packing nut to 1⁄4 to 1⁄2 turn past hand tight. Then use the wrench to attach tubing valve with yoke. Use new gasket supplied with container each time connection is made. Make sure connections are tight. Close auxiliary valve, open cylinder valve one half turn counterclockwise and then close immediately. Test for leaks with ammonia vapor. Appearance of white vapor indicates a chlorine leak. 

If a yoke is indicative tighten yoke and retest. If leak persists remove gasket and replace with a new gasket. Retest using the above procedure. 

Connection of containermanifold is not recommmanifold a new containtemperature as other cosystem. 
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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Municipal Water Supplies, Sewage and Waste Management Plants , Recirculating Cooling Water in Industrial Cooling Systems, Paper Mills and Other Industrial Applications (Continued) 

Pressurized Gas 550-200 6785-1 

Dispensing Equipment 

 If no leaks are detected, open auxiliary valve one turn and cylinder valve one turn. Disconnection: To disconnect close cylinder valve. Close auxiliary valve. Disconnect tubing and yoke. Test for leaks. Apply valve outlet cap with gasket and tighten. Replace valve protection hood on container. Plug or cap the open end of the chlorine line immediately to keep out moisture. 

Connection of containermanifold is not recommmanifold a new containtemperature as other cosystem. 

Municipal Water Supplies, Sewage and Wastewater Management Plants 

Pressurized Gas 7151-4 

Dispensing Equipment 

Using Chlorine in Cylinders, 

See Diagrams 1-4Connecting and Disconnecting: Use 500 psig copper tubing fitted with special adapter (4-A) to connect containers to piping system. To connect line to containers, remove valve protection hood (1) and valve outlet cap (2-A). 

Then use wrench (3) shown to attach tubing to valve with yoke (4-B). Use new gasket supplied with cylinder each time connection is made. Make sure connections are tight. Check for leaks with ammonia vapor. 

Handle and use only in recommended in the ChChlorine Institute. Only dispensing equipment swith the manufacturer’s state regulatory agency or residual chlorine levefor each specific site of 
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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Pressurized Gas 7151-4 

Dispensing Equipment 

Appearance of white vapor indicates Chlorine leak. Never use standard pipe fittings. 

 Handle and use only in recommended in the ChChlorine Institute. Only dispensing equipment swith the manufacturer’s state regulatory agency or residual chlorine levefor each specific site of 

Municipal Water Supplies, Sewage and Wastewater Management Plants (Continued) 

Pressurized Gas 33458-1 Technical Chemical 70529-1 

Dispensing Equipment 

General Instructions: Chlorine cylinders have one valve and will deliver gas chlorine in the upright position. Ton containers have to valves in one head: in the horizontal position with valves in a vertical line the will deliver gas from upper valve and liquid from lower valve. Connecting and Disconnecting: Use 500 psig copper tubing fitted with special adapter to connect container to piping system. To connect line to container, remove valve protection cap and valve outlet cap. Then use wrench shown to attach tubing to valve with yoke. Use new gasket supplied with container each time connection is made. Make sure connections are tight. Check for leaks with ammonia vapor. Never use 

New York use only. UsConnection of containermanifold is not recommmanifold a new containtemperature as other cosystem. Never heat chlonot place them in hot wbates. Be sure no water into container due to prewhen it is nearly emptyopen when chlorine is nHandle and use only in recommended in the ChChlorine Institute. 
Docket Number: EPA-HQ-OPP-2010-0242 

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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Municipal Water Supplies, Sewage and Wastewater Management Plants (Continued) 

Pressurized Gas 33458-1 Technical Chemical 70529-1 

Dispensing Equipment 

standard pipe fittings. Turn stem one full turn counterclockwise to open valve. Do not use container valve to regulate the chlorine. Use of valve for flow control may wear valve seat so that it cannot be tightly closed. Never force the valve stem. Hit wrench handle with the heel of the hand to loosen a stuck valve stem. Never use a hammer or other implements for this purpose. Packing may be loosened slightly to relieve tight stem, but retighten to avoid leak. To disconnect, close valve, test valve for leaks, apply valve outlet cap with gasket and protection hood. Plug or cap the open end of the chlorine line immediately to keep out moisture. 

New York use only. UsConnection of containermanifold is not recommmanifold a new containtemperature as other cosystem. Never heat chlonot place them in hot wbates. Be sure no water into container due to prewhen it is nearly emptyopen when chlorine is nHandle and use only in recommended in the ChChlorine Institute. 

Municipal Water Supplies, Sewage and Wastewater Management Plants and Industrial Water Treatment Systems 

Pressurized Gas 69874-4 84043-1 

Dispensing Equipment 

This product including dispensing equipment must be handled and used in accordance with the practices specified by all applicable product labeling and the Chlorine Manual published by the Chlorine 

Refer to the Chlorine MChlorine Institute for in
Docket Number: EPA-HQ-OPP-2010-0242 

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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Institute. 

Potable and Wastewater Treatment, Repacking into Smaller Containers 

Pressurized Gas 67649-5 

Dispensing Equipment 

Using Chlorine in Containers: Connecting and Disconnecting: Use a special adapter (4-A) to connect container to a piping system. To connect line to container, remove valve protection hood. (1-A) and valve outlet cap (2-A). Then use the wrench (3) shown to attach tubing to valve with yoke (4-B). Use a new gasket with each time a connection is made. Make sure connections are tight. Check for leaks with ammonia vapor. Appearance of white vapor indicates a chlorine leak. Never use standard pipe fittings. Turn the stem on full turn counterclockwise to open valve (2). Don’t use container valve (2) to regulate chlorine flow. Use of valve for flow control may wear valve seat so that it cannot be tightly closed. Never force the valve stem. Hit wrench handle with the heel of the hand to loosen a stuck valve stem. Never use a hammer or other implements for this purpose. Packaging nut may be loosened slightly to relieve tight stem, but retighten promptly to avoid leak. 

The registrant is solely servicing equipment, angas from larger containeton containers. Each re-EPA registration numbeand its own EPA EstablRe-packagers may only portable containers that are appropriately labeleRefer to the appropriate instructions on the requprocedures. 
Docket Number: EPA-HQ-OPP-2010-0242 

www.regulations.gov 30 of 69 

Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Potable and Wastewater Treatment, Repacking into Smaller Containers (Continued) 

Pressurized Gas 67649-5 

Dispensing Equipment 

To disconnect, close valve (2), disconnect yoke and adapter (4-A&4-B), test valve for leaks, apply valve outlet cap (2-A) with gasket. Replace valve protection hood (1) on container. Plug or cap the open end of chlorine line immediately to keep out moisture. 

The registrant is solely servicing equipment, angas from larger containeton containers. Each re-EPA registration numbeand its own EPA EstablRe-packagers may only portable containers that are appropriately labeleRefer to the appropriate instructions on the requprocedures. 

Sewage and Waste Water Treatment 

Pressurized Gas 37982-2 52374-12 

Flash Mix Mixing: It is imperative that the 

product and wastewater be instantaneously and completely flash mixed to assure reaction with every chemical active, soluble and particulate component of wastewater. Contacting: Upon flash mixing, 

the flow through the system must be maintained. Dosage/Residual Control: Successful disinfection is extremely dependent on response to fluctuating chlorine demand to maintain a predetermined, desirable chlorine level. Secondary effluent should contain 0.2 to 1.0 

The disinfect ion of sewevaluated by determinincoliforn bacteria and/or determined by the Most procedure, of the chlorito or below the maximuregulatory jurisdiction. 
Docket Number: EPA-HQ-OPP-2010-0242 

www.regulations.gov 31 of 69 

Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Pressurized Gas 37982-2 52374-12 

Flash Mix 

ppm chlorine residual after a 15 to 30 minute contact time. A reasonable average of residual chlorine is 0.5 ppm after 15 minutes contact time. Effluent Slime Control: Apply a 100 to 1,000 ppm available chlorine solution at a location which will allow complete mixing. Once control has become evident apply 15 ppm available chlorine solution. Filter Beds and Slime Control: Remove filter from service and drain. Prepare a 100 to 1,000 ppm available chlorine solution and fill a depth of 1 foot above filter sand. Wait 30 minutes before draining water to a level that is even with the top of the filter. Wait 4 to 6 hours before completely draining backwashing filter. 

The disinfect ion of sewevaluated by determinincoliforn bacteria and/or determined by the Most procedure, of the chlorito or below the maximuregulatory jurisdiction 

Sewage and Waste Water Treatment (Continued) 

Pressurized Gas 37982-39 

Not Listed Refer to the “Chlorine Manual 

published by the Chlorine Institute, Inc. for instructions on the required product use and safety procedures. 

Before working with thtrained how to appropriconforms to OSHA requappropriately handle an
Docket Number: EPA-HQ-OPP-2010-0242 

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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Pulp and Paper Process Water Systems, Potable and Wastewater Treatment, Cooling Tower Water Treatment (For Repackaging into Smaller Containers or for the Manufacture of Sodium Hypochlorite) 

Technical Chemical 464-99 Pressurized Gas 813-10 1744-10 

Dispensing Equipment 

Refer to the appropriate Chlorine Institute pamphlet for instructions and the required product use and safety procedures. 

This product including handled and used in accspecified by all approprappropriate CI pamphle

Pulp and Paper Mill Process Water Systems, Cooling Tower, Air Washer and Evaporative Condenser Water, Pasteurizer, Warmer and Cannery Cooling Water Systems Including Chillers 

Pressurized Gas 37982-2 52374-12 

Slug Feed, Intermittent Feed and Continuous Feed 

Slug Feed Method/ InitialDose: When system is noticeably fouled apply sufficient chlorine to obtain from 5 to 10 ppm available chlorine. Repeat until control is achieved. Badly fouled systems must be cleaned before initial treatment. Subsequent Doses: When microbial controls becomes evident, test daily and maintain a 1 ppm residual. Intermittent Feed Method: Initial Dose: When system is noticeably fouled, apply sufficient chlorine to obtain 5 to 10 ppm available chlorine. Apply half (or 1/3, 1⁄4, or 1/5) of this initial dose when half (or 1/3, 1⁄4, or 1/5) of the water in the system has been lost by blow down. Badly fouled systems 

Not Listed 
Docket Number: EPA-HQ-OPP-2010-0242 

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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Pulp and Paper Mill Process Water Systems, Cooling Tower, Air Washer and Evaporative Condenser Water, Pasteurizer, Warmer and Cannery Cooling Water Systems Including Chillers (Continued) 

Pressurized Gas 37982-2 52374-12 

Slug Feed, Intermittent Feed and Continuous Feed 

must be cleaned before initial treatment. Subsequent Doses: When microbial control is evident, test daily and maintain a residual of 1 ppm Apply half (or 1/3, 1⁄4, or 1/5) of this initial dose when half (or 1/3, 1⁄4, or 1/5) of the water in the system has been lost by blow down. Continuous Feed Method: Initial Dose: When system is noticeably fouled apply sufficient chlorine to obtain 5-10 ppm available chlorine. Repeat until control is achieved. Badly fouled systems must be cleaned before initial treatment. Subsequent Doses: When microbial control becomes evident, start a continuous feed and test daily to maintain 1 ppm residual. 

Not Listed 

Water Cooling Systems and Paper Mills 

Technical Chemical 37982-39 

Not Listed Refer to the Chlorine Manual 

published by the Chlorine Institute for instructions on the required product use and safety procedures. 

Before working with thtrained on how to approconforms to OSHA requappropriately handle an
Docket Number: EPA-HQ-OPP-2010-0242 

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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Pulp and Paper Process Water and Cooling Tower Water Treatment 

Pressurized Gas 67649-5 

Dispensing Equipment 

Refer to the “Chlorine Manual published by the Chlorine Institute, Inc. for instructions on the required product use and safety procedures. Using Chlorine in Containers: Connecting and Disconnecting: Use a special adapter (4-A) to connect container to a piping system. To connect line to container, remove valve protection hood. (1-A) and valve outlet cap (2-A). Then use the wrench (3) shown to attach tubing to valve with yoke (4-B). Use a new gasket with each time a connection is made. Make sure connections are tight. Check for leaks with ammonia vapor. Appearance of white vapor indicates a chlorine leak. Never use standard pipe fittings. Turn the stem on full turn counterclockwise to open valve (2). Don’t use container valve (2) to regulate chlorine flow. Use of valve for flow control may wear valve seat so that it cannot be tightly closed. Never force the valve stem. Hit wrench 

The registrant is solely servicing equipment, angas from larger containeton containers. Each re-EPA registration numbeEstablishment Number may only dispense this that are approved for chlabeled. 
Docket Number: EPA-HQ-OPP-2010-0242 

www.regulations.gov 35 of 69 

Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Pulp and Paper Process Water, Cooling Tower Water Treatment (Continued) 

Pressurized Gas 67649-5 

Dispensing Equipment 

handle with the heel of the hand to loosen a stuck valve stem. Never use a hammer or other implements for this purpose. Packaging nut may be loosened slightly to relieve tight stem, but retighten promptly to avoid leak. To disconnect, close valve (2), disconnect yoke and adapter (4-A&4-B), test valve for leaks, apply valve outlet cap (2-A) with gasket. Replace valve protection hood (1) on container. Plug or cap the open end of chlorine line immediately to keep out moisture. 

The registrant is solely servicing equipment, angas from larger containeton containers. Each re-EPA registration numbeEstablishment Number may only dispense this that are approved for chlabeled. 

Swimming Pool Industrial and Commercial Swimming Pools 

Pressurized Gas 266-35 5382-38 8996-6 50956-6 

Dispensing Equipment 

Not Listed Only specifically design

should be used in accorinstructions and accordirecommendations for dolevels which should be site of application. 
Docket Number: EPA-HQ-OPP-2010-0242 

www.regulations.gov 36 of 69 

Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Ready to Use 63802-1 Solid Agar 70264-1 

Dispensing Equipment 

Not Listed Only specifically design

should be used in accorinstructions and accordirecommendations for dolevels which should be site of application. 

 Industrial and Commercial Swimming Pools (Continued) 

Pressurized Gas 33458-1 Technical Chemical 70529-1 

Dispensing Equipment 

Handle and use only in accordance with practice recommended in the Chlorine Manual published by the Chlorine Institute. General Instructions: Chlorine cylinders have one valve and will deliver gas chlorine in the upright position. Ton containers have to valves in one head: in the horizontal position with valves in a vertical line the will deliver gas from upper valve and liquid from lower valve. 

New York use only. UsConnection of containermanifold is not recommmanifold a new containtemperature as other cosystem. Never heat chlonot place them in hot wbates. Be sure no water into container due to prewhen it is nearly emptyopen when chlorine is n
Docket Number: EPA-HQ-OPP-2010-0242 

www.regulations.gov 37 of 69 

Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Industrial and Commercial Swimming Pools (Continued) 

Pressurized Gas 33458-1 

Dispensing Equipment 

Connecting and Disconnecting: Use 500 psig copper tubing fitted with special adapter to connect container to piping system. To connect line to container, remove valve protection cap and valve outlet cap. Then use wrench shown to attach tubing to valve with yoke. Use new gasket supplied with container each time connection is made. Make sure connections are tight. Check for leaks with ammonia vapor. Never use standard pipe fittings. Turn stem one full turn counterclockwise to open valve. Do not use container valve to regulate the chlorine. Use of valve for flow control may wear valve seat so that it cannot be tightly closed. Never force the valve stem. Hit wrench handle with the heel of the hand to loosen a stuck valve stem. Never use a hammer or other implements for this purpose. Packing may be loosened 

slightly to relieve tight stem, but retighten to avoid leak. 

New York use only. UsConnection of containermanifold is not recommmanifold a new containtemperature as other cosystem. Never heat chlonot place them in hot wbates. Be sure no water into container due to prewhen it is nearly emptyopen when chlorine is n
Docket Number: EPA-HQ-OPP-2010-0242 

www.regulations.gov 38 of 69 

Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Pressurized Gas 33458-1 

Dispensing Equipment 

To disconnect, close valve, test valve for leaks, apply valve outlet cap with gasket and protection hood. Plug or cap the open end of the chlorine line immediately to keep out moisture. 

New York use only. UsConnection of containermanifold is not recommmanifold a new containtemperature as other cosystem. Never heat chlonot place them in hot wbates. Be sure no water into container due to prewhen it is nearly emptyopen when chlorine is n

Technical Chemical 37982-39 

Not Listed Refer to the Chlorine Manual 

published by the Chlorine Institute for instructions on the required product use and safety procedures. 

Before working with thtrained how to appropriconforms to OSHA requappropriately handle an

Pressurized Gas 148-707 Technical Chemical 72315-1 

Dispensing Equipment 

Not Listed New York use only. On

dispensing equipment swith the manufacturer’s state regulatory agency or residual chlorine levefor each specific site of 

Industrial and Commercial Swimming Pools (Continued) 

Pressurized Liquid 41209-4 

Not Listed Not Listed Only certain dispensing 

accordance with the maaccording to state regulfor dosages or residual maintained for each spe
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EPA Reg. no. 

Method of 

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Application Rate/ No. of 

applications 

Use 

Residential and NonResidential Swimming Pools Residential and NonResidential Swimming Pools (Continued) 

Pressurized Gas 813-10 1744-10 Technical Chemical 37982-39 464-99 

Dispensing Equipment Dispensing Equipment 

Refer to the appropriate Chlorine Institute pamphlet for instructions and the required product use and safety procedures. Refer to the appropriate Chlorine Institute pamphlet for instructions and the required product use and safety procedures. 

This product including handled and used in accspecified by all approprappropriate CI pamphleThis product including handled and used in accspecified by all approprappropriate CI pamphle

Residential Swimming Pools Pressurized 

Gas 67649-5 

Dispensing Equipment 

Refer to the appropriate Chlorine Institute pamphlet for instructions and the required product use and safety procedures. Using Chlorine in Containers: Connecting and Disconnecting: Use a special adapter (4-A) to connect container to a piping system. To connect line to container, remove valve protection hood. (1-A) and valve outlet cap (2-A). Then use the wrench (3) shown to attach tubing to valve with yoke (4-B). Use a new gasket with each time a connection is made. Make sure connections 

This product including handled and used in accspecified by all approprappropriate CI pamphle
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Method of 

Application 

Application Rate/ No. of 

applications 

Use 

 Residential Swimming Pools (Continued) 

Pressurized Gas 67649-5 

Dispensing Equipment 

are tight. Check for leaks with ammonia vapor. Appearance of white vapor indicates a chlorine leak. Never use standard pipe fittings. Turn the stem on full turn counterclockwise to open valve (2). Don’t use container valve (2) to regulate chlorine flow. Use of valve for flow control may wear valve seat so that it cannot be tightly closed. Never force the valve stem. Hit wrench handle with the heel of the hand to loosen a stuck valve stem. Never use a hammer or other implements for this purpose. Packaging nut may be loosened slightly to relieve tight stem, but retighten promptly to avoid leak. To disconnect, close valve (2), disconnect yoke and adapter (4-A&4-B), test valve for leaks, apply valve outlet cap (2-A) with gasket. Replace valve protection hood (1) on container. Plug or cap the open end of chlorine line immediately to keep out moisture. 

This product including handled and used in accspecified by all approprappropriate CI pamphle
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EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Pressurized Gas 43407-1 45851-1 56410-1 58618-1 

Dispensing Equipment 

Handle and use only in accordance with practice recommended in the chlorine manual published by the Chlorine Institute. 

Only specifically designshould be used in accorinstructions and accordirecommendations for dolevels which should be site of application. 

Pressurized Gas 52134-1 56652-1 

Dispensing Equipment 

Not Listed. Only specifically design

should be used in accorinstructions and accordirecommendations for dolevels which should be site of application. New 

Residential Swimming Pool (Continued) 

Pressurized Gas 56572-2 

Chlorine Sparger or Injection Systems 

Always adjust pH between 7.8 and 8.2 after the application of this product. Total alkalinity levels should be maintained at between 80 ppm-140 ppm with 100 ppm to 120 ppm considered ideal in most cases. Maintain cynauric acid level between 50 ppm and 100 ppm. For a newly filled pool or spring start-up, super chlorinate as indicated above. Adjust and maintain the alkalinity of the 

Do not use pool for one product or until availabto 4.0 ppm as determine
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Method of 

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Application Rate/ No. of 

applications 

Use 

 pool between 80 ppm to 140 

ppm. Adjust cynauric acid level to 100ppm. 

Residential Swimming Pool (Continued) 

Technical Chemical 70529-1 

Dispensing Equipment 

Handle and use only in accordance with practice recommended in the Chlorine Manual published by the Chlorine Institute. General Instructions: Chlorine cylinders have one valve and will deliver gas chlorine in the upright position. Ton containers have to valves in one head: in the horizontal position with valves in a vertical line that will deliver gas from upper valve and liquid from lower valve. Connecting and Disconnecting: Use 500 psig copper tubing fitted with special adapter to connect container to piping system. To connect line to container, remove valve protection cap and valve outlet cap. Then use wrench shown to attach tubing to valve with yoke. Use new gasket supplied with container each time connection 

New York use only. UsConnection of containermanifold is not recommmanifold a new containtemperature as other cosystem. Never heat chloDo not place them in hodischarge bates. Be sure sucked back into contaiespecially when it is necontainer valves open w
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Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Residential Swimming Pool (Continued) 

Technical Chemical 70529-1 

Dispensing Equipment 

is made. Make sure connections are tight. Check for leaks with ammonia vapor. Never use standard pipe fittings. Turn stem one full turn counterclockwise to open valve. Do not use container valve to regulate the chlorine. Use of valve for flow control may wear valve seat so that it cannot be tightly closed. Never force the valve stem. Hit wrench handle with the heel of the hand to loosen a stuck valve stem. Never use a hammer or other implements for this purpose. Packing may be loosened slightly to relieve tight stem, but retighten to avoid leak. To disconnect, close valve, test valve for leaks, apply valve outlet cap with gasket and protection hood. Plug or cap the open end of the chlorine line immediately to keep out moisture. 

New York use only. UsConnection of containermanifold is not recommmanifold a new containtemperature as other cosystem. Never heat chloDo not place them in hodischarge bates. Be sure sucked back into contaiespecially when it is necontainer valves open w
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Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Commercial Swimming Pools Commercial Swimming Pools (Continued) 

Pressurized Gas 550-200 6785-1 Pressurized Gas 550-200 

Dispensing Equipment Dispensing Equipment 

Refer to the Chlorine Manual published by the Chlorine Institute for instructions on the required product use and procedures. Using Chlorine in Containers (See Diagrams 1-4)Connecting and Disconnecting: Use 500 Psig Copper Tubing filtered with special adapter (4-A Cylinder 4-B for Ton Container) to connect container to piping system.  To connect line to container remove valve protection hood. (1) Check to ensure cylinder valve is closed: valve closes clockwise. Adjust packing nut to 1⁄4 to 1⁄2 turn past hand tight. Then use the wrench to attach tubing valve with yoke. Use new gasket supplied with container each time connection is made. Make sure connections are tight. Close auxiliary valve, open cylinder valve one half turn counterclockwise and then close immediately. Test for leaks with 

Connection of containermanifold is not recommmanifold a new containtemperature as other cosystem. Connection of containermanifold is not recommmanifold a new containtemperature as other cosystem. 
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applications 

Use 

Pressurized Gas 550-200 

Dispensing Equipment 

ammonia vapor. Appearance of white vapor indicates a chlorine leak. If a yoke is indicative tighten yoke and retest. If leak persists remove gasket and replace with a new gasket. Retest using the above procedure. If no leaks are detected, open auxiliary valve one turn and cylinder valve one turn. Disconnection: To disconnect close cylinder valve. Close auxiliary valve. Disconnect tubing and yoke. Test for leaks. Apply valve outlet cap with gasket and tighten. Disconnection: Replace valve protection hood on container. Plug or cap the open end of the chlorine line immediately to keep out moisture. 

Connection of containermanifold is not recommmanifold a new containtemperature as other cosystem. 

Commercial Swimming Pools (Continued) 

Pressurized Gas 7151-4 

Dispensing Equipment 

Using Chlorine in Cylinders, See Diagrams 1-4 Connecting and Disconnecting: Use 500 psig copper tubing fitted with special adapter (4-A) to connect containers to piping system. To connect line to containers, remove valve protection hood (1) and valve outlet cap (2-A). 

Handle and use only in recommended in the ChChlorine Institute. Only dispensing equipment swith the manufacturer’s state regulatory agency or residual chlorine levefor each specific site of 
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Use 

Then use wrench (3) shown to attach tubing to valve with yoke (4-B). Use new gasket supplied with cylinder each time connection is made.  Make sure connections are tight. Check for leaks with ammonia vapor. Appearance of white vapor indicates Chlorine leak. 

Never use standard pipe fittings 

Technical Chemical 45849-1 

Dispenser or Injection System 

This product is to be dispensed into water through the process of diffusion using a chlorine disperser or injection system. Always adjust pH between 7.8 and 8.2 after application of this product. Total alkalinity levels should be maintained between 80 ppm and 140 ppm with 100 ppm to 120 ppm considered ideal in most cases. Maintain cynauric acid level between 50 ppm and 100 ppm. For newly filled pools, adjust and maintain same levels as above. 

Do not use pool for one product or until the free dropped to 5.0 ppm as d

Swimming Pools 

Pressurized Gas 52374-12 

Chlorinator New Pool or Spring Start up: 

Using an appropriate chlorinator and following the manufacturer’s directions, super chlorinate the pool with 5 to 10 ppm available chlorine by weight. Check the level of available chlorine with a test kit. 

Do not enter the pool unbetween 1.0 to 3.0 ppm
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Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Pressurized Gas 52374-12 

Chlorinator 

Adjust and maintain pool water pH between 7.2 and 7.6. Adjust and maintain alkalinity of the pool to between 50 and 100 ppm. Pool Maintenance: Using an appropriate chlorinator and the following manufacturer’s directions, add chlorine to obtain 0.6 to 1.0 ppm available chlorine by weight.  Stabilized pools should maintain a residual of 1.0 to 1.5 ppm available chlorine. Test the pH, available chlorine residual and alkalinity of the water frequently with appropriate test kits. Frequency of water treatment will depend upon temperature and number of swimmers. Every 7 days or as necessary, using an appropriate chlorinator and following manufacturer’s directions super chlorinate the pool water by raising the available chlorine to 5 to 10 ppm available chlorine by weight. Check the level of available chlorine with a test kit. 

Do not enter the pool unbetween 1.0 to 3.0 ppm

Swimming Pools (Continued) 

Technical Chemical 69874-5 

Not Listed This product including 

dispensing equipment must be handled and used in accordance 

Refer to the Chlorine MChlorine Institute, Inc., procedures. 
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EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

with the practices specified by all applicable product labeling and the Chlorine Manual published by the Chlorine Institute. 

Industrial and Commercial Swimming Pools 

Pressurized Gas 266-35 

Not Listed Not Listed Only certain dispensing 

accordance with the maaccording to state regulfor dosages or residual maintained for each spe

Residential Swimming Pools, Spas, Hot Tubs, Hubbard and Immersion Tanks and Hydrotherapy Tanks 

Pressurized Gas 37982-2 

Manually or Feeder Device 

Residential Pools: For new pool or spring start-up, super chlorinate with 5 to 10 ppm available chlorine by weight. Check the level of available chlorine with a test kit. Adjust and maintain pH between 7.2 to 7.6. Adjust and maintain the alkalinity of the pool to between 50 to 100 ppm. To maintain the pool, add manually or by feeder device to yield an available chlorine residual between 0.6 to 1.0 ppm by weight. Stabilized pools should maintain a residual of 1.0 

Do not chlorinate the podischarge. 
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Application Rate/ No. of 

applications 

Use 

Residential Swimming Pools, Spas, Hot Tubs, Hubbard and Immersion Tanks and Hydrotherapy Tanks (Continued) 

Pressurized Gas 37982-2 

Manually or Feeder Device 

to 1.5 ppm available chlorine. Test the pH, available chlorine residual and alkalinity of the water frequently with appropriate test kits. Frequency of water treatment will depend upon temperature and number swimmers. Residential Pools: Every 7 days, or as necessary, super chlorinate the pool by raising the available chlorine to 5 to 10 ppm available chlorine by weight.  Check the level of available chlorine to 5 to 10 ppm available chlorine by weight. Check the level of available chlorine with a test kit. Do not re-enter pool until the chlorine residual is between 1.0 to 3.0 ppm. At the end of the swimming pool season or when water is to be drained from the pool, chlorine must be allowed to dissipate from treated pool water before discharge. 

Spas, Hot-Tubs: Apply 

Do not chlorinate the podischarge. 
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Use 

Residential Swimming Pools, Spas, Hot Tubs, Hubbard and Immersion Tanks and Hydrotherapy Tanks (Continued) 

Pressurized Gas 37982-2 

Manually or Feeder Device 

sufficient chlorine to obtain 5 ppm, as determined by a suitable chlorine test kit. Adjust and maintain pool water pH 7.2 and 7.8. Some oils, lotions, fragrances, cleaners, etc. may cause foaming or cloudy water as well as reduce the efficiency of the product. Maintain the water at 5 ppm available chlorine during use.  During extended periods of disuse, maintain a 3 ppm chlorine concentration. Hubbard and Immersion Tanks: Before patient use adjust bath to obtain chlorine residual 25 ppm as determined by a suitable test kit. Adjust and maintain the water pH to between 7.2 and 7.6. After each use drain the tank. Prepare a fresh 25 ppm available chlorine solution in a bucket and circulate this solution through the agitator of the tank for 15 minutes and then rinse out the solution. Clean tank thoroughly dry with clean cloths. Hydrotherapy Tanks: Adjust to obtain a 1 ppm residual, as determined by a suitable 

Do not chlorinate the podischarge. 
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applications 

Use 

chlorine test kit. Pool should not be entered until the chlorine residual is below 3 ppm. Adjust and maintain the water pH to between 7.2 and 7.6. Operate pool filter continuously. Drain pool weekly and clean before refilling. 

Food Handling/Storage Establishments Premises and Equipment Wash Water Treatment of Food Handling Premises Equipment and Food Commodities 

Technical Chemical 464-99 Pressurized Gas 813-10 1744-10 

Dispensing Equipment 

Not Listed This product including 

handled and used in accspecified by all approprappropriate CI pamphle

Packing House Equipment for Meat, Fish, Poultry, Egg, Winery, Cannery and other Food Processing and Packing Plants 

Pressurized Gas 2686-3 

Rinse, Immersion, Slug Feed, Intermitted Feed and Continuous Feed 

Sanitization of Nonporous 

Food Contact Surfaces 

Rinse and Immersion Method: A solution of 100 ppm available chlorine may be used in sanitizing solution. Solutions containing an initial concentration of 100 ppm available chlorine must be tested and adjusted periodically to insure that available chlorine does drop below 50 ppm. 

Do not rinse equipment do not soak equipment o Sanitizers used in automof non-porous food congeneral cleaning but mapurposes. If additional additives, santi-foam agents and otdo not reuse this water ounless these additives h
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Method of 

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Application Rate/ No. of 

applications 

Use 

Packing House Equipment for Meat, Fish, Poultry, Egg, Winery, Cannery and other Food Processing and Packing Plants (Continued) 

Pressurized Gas 2686-3 

Rinse, Immersion, Slug Feed, Intermitted Feed and Continuous Feed 

Check the concentration of available chlorine using a chlorine test kit. Rinse Method: Clean equipment surfaces in the normal manner. Prior to use, rinse all surfaces thoroughly with the sanitizing solutions, maintaining contact with the sanitizer for at least 2 minutes.  If solution contains less than 50 ppm available chlorine, as determined by a suitable test kit, discard the solutions. Immersion Method: Clean equipment surfaces in the normal manner. Prior to use, immerse equipment in sanitizing solution for at least 2 minutes and allow sanitizer to drain.  If solution contains less than 50 ppm available chlorine, as determined by a suitable test kit, discard the solutions. 

Sanitization of Porous Food 

Contact Surfaces 

Rinse Method: A solution of 600 ppm available chlorine may be used to sanitize food contact surfaces. Clean surfaces in the 

Do not rinse equipment do not soak equipment oSanitizers used in automnon-porous food contacgeneral cleaning but mapurposes. If additional additives, santi-foam agents and otdo not reuse this water ounless these additives h
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Application Rate/ No. of 

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Use 

Packing House Equipment for Meat, Fish, Poultry, Egg, Winery, Cannery and other Food Processing and Packing Plants (Continued) 

Pressurized Gas 2686-3 

Rinse, Immersion, Slug Feed, Intermitted Feed and Continuous Feed 

normal manner. Prior to use, rinse all surfaces thoroughly with 600 ppm sanitizing solution, maintaining contact with sanitizer for at least 2 minutes. Prior to using equipment, rinse all surfaces with a 200 ppm available chlorine solution. Immersion Method: Prepare a solution containing 600 ppm available chlorine. Clean equipment in the normal manner. Prior to use, immerse equipment sanitizing solution for at least 2 minutes and allow the sanitizer to drain. Prior to using equipment, immerse all surfaces in 200 ppm available chlorine solution. Slug and Intermitted Feed Method/Initial Dose: When system is noticeably fouled, maintain 5-10 ppm available chlorine in the water. Subsequent Dose: When 

microbial control is evident, maintain the chlorine residual at 1 ppm. Badly fouled systems must be cleaned before treatment 

Do not rinse equipment do not soak equipment oSanitizers used in automnon-porous food contacgeneral cleaning but mapurposes. If additional additives, santi-foam agents and otdo not reuse this water ounless these additives h
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Method of 

Application 

Application Rate/ No. of 

applications 

Use 

 Packing House Equipment for Meat, Fish, Poultry, Egg, Winery, Cannery and other Food Processing and Packing Plants (Continued) 

Pressurized Gas 2686-3 

 Rinse, Immersion, Slug Feed, Intermitted Feed and Continuous Feed 

is begun. Continuous Feed Method/Initial Dose: When system is noticeably fouled, maintain 5-10 ppm available chlorine in the water. Subsequent Dose: Adjust the chlorinator to deliver chlorine continuously so a level of 1 ppm available chlorine can be maintained in the water. Badly fouled systems must be cleaned before treatment is begun. Chlorination of Incoming Water: For entire incoming 

water supply, to be used in plant chlorination, maintain in the water a free available chlorine residual of 5-7 ppm. Can-Cooling Water: Maintain 

1 ppm available chlorine in water use for cooling sealed cans after heat sterilization. 

Do not rinse equipment do not soak equipment oSanitizers used in automnon-porous food contacgeneral cleaning but mapurposes. If additional additives, santi-foam agents and otdo not reuse this water o

unless these additives h
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Application Rate/ No. of 

applications 

Use 

Egg Handling Equipment, Fish and Seafood Processing Equipment, Meat Processing Equipment, Poultry Processing Equipment 

Pressurized Gas 37982-2 

Spray Spray Method: Cover or 

remove all food and packaging materials. Pre-clean equipment with an appropriate cleaning solution and rinse. Spray the equipment with a 50 ppm available chlorine solution. 

Not Listed 

Food Processing Water Systems Food Processing Water Systems 

Pressurized Gas 37982-2 Pressurized Gas 37982-2 

Slug Feed, Intermittent Feed, Continuous Feed Slug Feed, Intermittent Feed, Continuous Feed 

Slug Feed Method: Initial Dose: when system is noticeably fouled apply sufficient chlorine to obtain 20 ppm available chlorine. Repeat until control is achieved. Badly fouled systems must be cleaned before initial treatment. Subsequent Doses: When microbial controls become evident, test daily and maintain a 1 ppm residual. Intermittent Feed Method/Initial Dose: When system is noticeably fouled, apply sufficient chlorine to obtain 20 ppm available chlorine. Apply half (or 1/3, 1⁄4, or 1/5) of this initial dose when half (or 1/3, 1⁄4, or 1/5) of the water in the system has been lost by blow down. Badly fouled systems must be cleaned before initial treatment. 

Not Listed Not Listed 
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Method of 

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Application Rate/ No. of 

applications 

Use 

Food Processing Water Systems Pressurized 

Gas 37982-2 

Slug Feed, Intermittent Feed, Continuous Feed 

Subsequent Doses: When microbial control becomes evident, test daily and maintain a 1 ppm residual. Apply (or 1/3, 1⁄4, or 1/5) of this initial dose when half (or 1/3, 1⁄4, or 1/5) of the water in the system has been lost by blow down. Continuous Feed Method/ Initial Dose: When system is noticeably fouled apply sufficient chlorine to obtain from 20 ppm available chlorine. Repeat until control is achieved. Badly fouled systems must be cleaned before initial treatment. Subsequent Doses: When microbial control becomes evident, start a continuous feed test daily to maintain 1 ppm residual. 

Not Listed 

Food Processing Plant, Food Contact and Non-Contact Surfaces 

Technical Chemical 37982-39 

Not Listed Refer to the Chlorine Manual 

published by the Chlorine Institute for instructions on the required product use and safety procedures. 

Before working with thtrained how to appropriconforms to OSHA requappropriately handle an

Sanitation of Packing House Equipment, Meat, Fish, Poultry, and Egg Processing Plants 

Pressurized Gas 67799-1 

Dispensing Equipment 

Not Listed This product is intended 

personnel or under the sSeaco Technologies. Re(Seachlor 100 Chlorine specific application inst

Agricultural Premises and Equipment 
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Method of 

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Application Rate/ No. of 

applications 

Use 

Wash Water for Raw Agricultural Commodities 

Technical Chemical 464-99 Pressurized Gas 813-10 

Dispensing Equipment 

Not Listed This product including 

handled and used in accspecified by all approprappropriate CI pamphle

Wash Water for Raw Agricultural Commodities and Repacking into Smaller Containers 

Technical Chemical 37982-39 

Not Listed Refer to the Chlorine Manual 

published by the Chlorine Institute for instructions on the required product use and safety procedures. 

Before working with thtrained how to appropriconforms to OSHA requappropriately handle an

Wash Water for Raw Agricultural Commodities, Repacking into Smaller Container and to Manufacture Sodium Hypochlorite 

Pressurized Gas 67649-5 

Dispensing Equipment 

Refer to the Chlorine Manual published by the Chlorine Institute for instructions on the required product use and safety procedures. Using Chlorine in Containers: Connecting and Disconnecting: Use a special adapter (4-A) to connect container to a piping system. To connect line to container, remove valve protection hood. (1-A) and valve outlet cap (2-A). Then use the wrench (3) shown to attach tubing to valve with yoke (4-B). Use a new gasket with each time a connection is made. Make sure connections 

The registrant is solely servicing equipment, angas from larger containeton containers. Each re-EPA registration numbeand its own EPA EstablRe-packagers may only portable containers that are appropriately labele
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Method of 

Application 

Application Rate/ No. of 

applications 

Use 

 Wash Water for Raw Agricultural Commodities, Repacking into Smaller Containers and to Manufacture Sodium Hypochlorite 

Pressurized Gas 67649-5 

Dispensing Equipment 

are tight. Check for leaks with ammonia vapor. Appearance of white vapor indicates a chlorine leak. Never use standard pipe fittings. Turn the stem on full turn counterclockwise to open valve (2). Don’t use container valve (2) to regulate chlorine flow. Use of valve for flow control may wear valve seat so that it cannot be tightly closed. Never force the valve stem. Hit wrench handle with the heel of the hand to loosen a stuck valve stem. Never use a hammer or other implements for this purpose. Packaging nut may be loosened slightly to relieve tight stem, but retighten promptly to avoid leak. To disconnect, close valve (2), disconnect yoke and adapter (4-A&4-B), test valve for leaks, apply valve outlet cap (2-A) with gasket. Replace valve protection hood (1) on container. Plug or cap the open end of chlorine line immediately to keep out moisture. 

 The registrant is solely servicing equipment, angas from larger containeton containers. Each re-EPA registration numbeand its own EPA EstablRe-packagers may only portable containers that are appropriately labele

Egg Plant, Hatcheries, Brooder Rooms, Shoe Baths and Post Harvest Treatment of Fruits and 

Pressurized Gas 37982-2 

Spray Spray Method: Cover or 

remove all food and packaging materials. Pre-clean equipment 

Not Listed 
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Method of 

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Application Rate/ No. of 

applications 

Use 

Vegetables  Egg Plant, Hatcheries, Brooder Rooms, Shoe Baths and Post Harvest Treatment of Fruits and Vegetables 

Pressurized Gas 37982-2 

Spray 

with an appropriate cleaning solution and rinse. Spray the equipment with a 50 ppm available chlorine solution. Post Harvest Treatment of Fruits and Vegetables: For the control of microorganisms causing decay of fruits and vegetables please refer to the following tables (see label) for the recommended concentration levels of available chlorine. Post Harvest Treatment of Fruits and Vegetables: For treatment of fruit and vegetable commodities, do not rinse with fresh water after treatment. After treatment, moisture must be removed by centrifuging. Mushrooms must be treated with an anti-oxidant after chlorine treatment to prevent browning. 

Not Listed 

Post Harvest Process for Fruits and Vegetables and Sanitation of Farm Buildings 

Pressurized Gas 67799-1 

 Dispensing Equipment 

Not Listed This product is intended 

personnel or under the sSeaco Technologies. Re(Seachlor 100 Chlorine specific application inst

Sanitizing Use for Fruits and Vegetable Wash Water Treatment 

Technical Chemical 69874-5 

Dispensing Equipment 

This product including dispensing equipment must be handled and used in accordance 

Refer to the Chlorine MChlorine Institute for in
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EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

with the practices specified by all applicable product labeling and the Chlorine Manual published by the Chlorine Institute. 

Agricultural Irrigation Systems Agricultural Irrigation Systems (Continued) 

Pressurized Gas 37982-2 Pressurized Gas 37982-2 

Drip/Trickle or Sprinkler Drip/Trickle or Sprinkler 

Calibration: If the irrigation water has high levels of nutrients causing bacterial, algae, or other 

bio-fouling that reduces system performance, continuous chlorination may be necessary. The recommended level of free residual chlorine for continuous feed is 1 to 2 ppm, measured at the end of the farthest lateral using a good quality test kit for free chlorine (also called “free residual” or “free available” chlorine). Periodic shock treatments at a higher chlorine rate of up to 20 ppm free residual may be appropriate where bacteria and/or algae clogging and buildup are not managed by maintaining a continuous residual. The frequency of the chlorine shock application 

Do not connect any irriggreenhouse systems into to a public water system prescribed by the state DDrinking Water Branchprotection are in place. Do not connect any irriggreenhouse systems into to a public water system 

prescribed by the state DDrinking Water Branchprotection are in place. 
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Application Rate/ No. of 

applications 

Use 

Agricultural Irrigation Systems (Continued) 

Pressurized Gas 37982-2 

Drip/Trickle or Sprinkler 

depends upon the frequency and extent bio-clogging. Super chlorination, bringing chlorine concentrations to as much 100 ppm total chlorine, is recommended for reclaiming low-volume irrigation systems if clogged by algae and bacterial slimes. Set the chlorinator to deliver 100 ppm in the drip system and monitor the free chlorine residual at the end of the farthest lateral. As soon as it is established that the free residual reading between 10 to 20 ppm, shut the system down and leave it undisturbed for up to 24 hours. Then flush all sub-mains and laterals with fresh waster. Super chlorination will not dissolve or remove scale or inorganic sediment fouling. 

Do not connect any irriggreenhouse systems into to a public water system prescribed by the state DDrinking Water Branchprotection are in place 

Human Drinking Water Systems Public Systems, Public Water Systems, Dug Wells, Drilled, Driven and Bored Wells and Flowing Artesian Wells 

Pressurized Gas 37982-2 52374-12 

Feed with a Hypochlorinator. Spray Public Systems: Prepare a 100 ppm available chlorine solution. 

Begin feeding this solution with a hypochlorinator until free available chlorine residual of at least 0.2 ppm and no more than 0.6 ppm is attained throughout the distribution system. Check 

Chlorine must be applieconcentration for sufficthe required disinfectionfree chlorine must be mexceed 4.0 ppm at any c
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applications 

Use 

Public Systems, Public Water Systems, Dug Wells, Drilled, Driven and Bored Wells and Flowing Artesian Wells 

Pressurized Gas 37982-2 52374-12 

Feed with a Hypochlorinator, Spray 

water frequently with a chlorine test kit. Bacteriological sampling must be conducted at a frequency no less than that prescribed by National Interim Primary Drinking Water Regulations. Individual Systems-Dug Wells:Upon completion of the casing (lining) wash the interior of casing (lining) with a 100 ppm available chlorine solution using a stiff brush. After covering the well, pour sanitizing solution into well through both the pipe sleeve opening and the pipeline. Wash the exterior of the pump cylinder 

also with the sanitizing solution. Start pump and pump water until strong odor if chlorine water in water is noted. Stop pump and wait at least 24 hours. After 24 hours flush well until all traces of chlorine have been removed from the water. 

Individual Systems-Drilled, Driven, and Bored Wells: Run pump until water is as free from turbidity as possible. Pour a 100 

Chlorine must be applieconcentration for sufficthe required disinfectionfree chlorine must be mexceed 4.0 ppm at any c
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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Public Systems, Public Water Systems, Dug Wells, Drilled, Driven and Bored Wells and Flowing Artesian Wells 

Pressurized Gas 37982-2 52374-12 

 Feed with a Hypochlorinator, Spray 

ppm available chlorine sanitizing solution into the well. Add 5 to 10 gallons of clean chlorinated water to the well in order to force the sanitizer into rock formation. Wash the exterior of pump cylinder with the sanitizer. Drop pipeline into well, start pump and pump water until strong odor of chlorine is noted. Stop pump and wait at least 24 hours. Individual Systems-Drilled, Driven, and Bored Wells: After 24 hours flush well until all traces of chlorine have been removed from the water. Deep wells with high water levels may necessitate the use of special methods for introduction of the sanitizer into the well. Individual Systems-Flowing Artesian Wells: Artesian wells generally do not require disinfection. If analyses indicate 

persistent contamination, the well should be disinfected. Emergency Disinfection: When 

Chlorine must be applieconcentration for sufficthe required disinfectionfree chlorine must be mexceed 4.0 ppm at any c
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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Public Systems, Public Water Dug Wells, Drilled, Driven, Bored Wells and Flowing Artesian Wells 

Pressurized Gas 37982-2 52374-12 

Feed with a Hypochlorinator, Spray 

boiling of water for 1 minute is not practical, water can be made potable by using this product. Prior to addition of the sanitizer, remove all suspended material by filtration or by allowing it to settle to the bottom. Emergency Disinfection:Decant the clarified, contaminated water to a clean container and add sufficient chlorine to obtain 0.5 ppm. Allow the treated water to stand for 30 minutes. Properly treated water should have a slight chlorine odor, if not repeat dosage and allow the water to stand an additional 15 minutes.  The treated water can then be made palatable by pouring it between clean containers several times. Public Water Systems:Algae Control in Reservoirs:Hypochlorinate streams feeding 

the reservoir. Suitable feeding points should be selected on each stream at least 50 yards upstream from the points of 

Chlorine must be applieconcentration for sufficthe required disinfectionfree chlorine must be mexceed 4.0 ppm at any c
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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

 Public Systems, Public Water Dug Wells, Drilled, Driven, Bored Wells and Flowing Artesian Wells 

Pressurized Gas 37982-2 52374-12 

Feed with a Hypochlorinator, Spray 

entry into the reservoir. Mains: Thoroughly flush section to be sanitized by discharging from hydrants. Permit a water flow of at 2.5 feet per minute to continue under pressure while injecting this product by means of a hypochlorinator. Stop water flow when chlorine a chlorine when a chlorine residual test of 50 ppm is obtained at the low pressure end of the new main section after 24 hours retention time. When chlorination is completed, the system must be flushed free of all heavily chlorinated water. New Tanks, Basins: Remove all 

physical soil from surfaces. Prepare a 500 ppm available chlorine solution. Fill to working capacity and allow solution to stand for at least 4 hours. Drain and flush potable water and place in service. New Filter Sand: Before 

placing filter in service, prepare a 100 to 1000 ppm available chlorine solution and fill to a depth of 1 foot above filter sand. 

Chlorine must be applieconcentration for sufficthe required disinfectionfree chlorine must be mexceed 4.0 ppm at any c
Docket Number: EPA-HQ-OPP-2010-0242 

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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

 Public Systems, Public Water Dug Wells, Drilled, Driven and Bored Wells and Flowing Artesian Wells 

Pressurized Gas 37982-2 52374-12 

Feed with a Hypochlorinator, Spray 

Wait 30 minutes before draining water to a level that is even with the top filter. Wait for 4 to 6 hours before completely draining and backwashing filter. New Wells: Flush the casing with a 50 ppm available chlorine solution. The solution should be pumped or fed by gravity into the well after thorough mixing with agitation. The well should stand for several hours or overnight under chlorination. It may then be pumped until a representative raw water sample is obtained.  Bacterial examination of the water will indicate whether further treatment is necessary. Existing Equipment: Remove 

equipment from service and thoroughly clean surfaces of all physical soil. Sanitize with a 500 ppm available chlorine solution. Fill working capacity and let stand at least 4 hours. Drain and return to service. If the previous treatment is not practical, surfaces may be sprayed with a solution containing 1000 ppm available chlorine. After drying, flush with water and return to service. 

Chlorine must be applieconcentration for sufficthe required disinfectionfree chlorine must be mexceed 4.0 ppm at any c
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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Municipal Drinking water Supplies 

Pressurized Gas 37982-39 

Not Listed Refer to the Chlorine Manual 

published by the Chlorine Institute for instructions on the required product use and safety procedures. 

 Before working with ttrained how to appropriconforms to OSHA requappropriately handle an

Human Drinking Water Treatment 

Technical Chemical 69874-5 

Not Listed This product including 

dispensing equipment must be handled and used in accordance with the practices specified by all applicable product labeling and the Chlorine Manual published by the Chlorine Institute. 

Refer to the Chlorine MChlorine Institute for in

Aquatic Areas Agricultural Irrigation Systems Pressurized 

Gas 37982-2 

Drip/Trickle or Sprinkler 

Calibration: If the irrigation water has high levels of nutrients causing bacterial, algae, or other 

bio-fouling that reduces system performance, continuous chlorination may be necessary. The recommended level of free residual chlorine for continuous feed is 1 to 2 ppm, measured at the end of the farthest lateral using a good quality test kit for free chlorine (also called “free residual” or “free available” chlorine). Periodic shock treatments at a higher chlorine rate of up to 20 

 Do not connect any irrgreenhouse systems into to a public water system prescribed by the state DDrinking Water Branchprotection are in place. 
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www.regulations.gov 68 of 69 

Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Pressurized Gas 37982-2 

Drip/Trickle or Sprinkler 

ppm free residual may be appropriate where bacteria and/or algae clogging and buildup are not managed by maintaining a continuous residual. The frequency of the chlorine shock application depends upon the frequency and extent bio-clogging. Super chlorination, bringing chlorine concentrations to as much 100 ppm total chlorine, is recommended for reclaiming low-volume irrigation systems if clogged by algae and bacterial slimes. Set the chlorinator to deliver 100 ppm in the drip system and monitor the free chlorine residual at the end of the farthest lateral. As soon as it is established that the free residual reading between 10 to 20 ppm, shut the system down and leave it undisturbed for up to 24 hours. Then flush all sub-mains and laterals with fresh waster. Super chlorination will not dissolve or remove scale or inorganic sediment fouling. 

Do not connect any irriggreenhouse systems into to a public water system prescribed by the state DDrinking Water Branchprotection are in place. 

Agricultural Irrigation Systems (Continued) 

Ready-to-Use 81987-1 

Drip, Trickle or Sprinkler , Vacuum Regulator, Ejector 

Refer to the Chlorine Manual published by the Chlorine Institute for instructions on the 

Do not connect any irriggreenhouse systems into to a public water system 
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Use Site Formulation/ 

EPA Reg. no. 

Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Device required product use and safety 

procedures. 

prescribed by the state DDrinking Water Branchprotection are in place. 

Drip Irrigation Systems Pressurized 

Gas 67799-1 

Dispensing Equipment 

Not Listed This product is intended 

personnel or under the sSeaco Technologies. Re(Seachlor 100 Chlorine specific application inst

Fountains, Ponds, and Ornamental Lakes 

Pressurized Gas 37982-2 

Manually or Feeder Device 

Fountains, Ponds and Ornamental Lakes: The recommended concentration level of available chlorine for the control of algae and slime in fountains, ponds and ornamental lakes containing no fish or wildlife is 3-5 ppm. 

Do not chlorinate the podischarge. 

Reservoirs Pressurized 

Gas 37982-2 

Hypochlorinator Algae Control in Reservoirs:

Hypochlorinate streams feeding the reservoir. Suitable feeding points should be selected on each stream at least 50 yards upstream from the points of entry into the reservoir. 

Not Listed 

Decorative Lakes, Fountains and Ponds 

Pressurized Gas 56410-1 58618-1 

Dispensing Equipment 

Handle and use only in accordance with practice recommended in the Chlorine Manual published by the Chlorine Institute. 

Only specifically designshould be used in accorinstructions and accordirecommendations for dolevels which should be site of application.