### Draft for Comment Version

– March 1, 2014



# Appendix B: Inhalation Equivalent

Concentration Calculations for the

Registration Review Chemical Analysis

Office of Pesticide Programs

Office of Chemical Safety and Pollution Prevention

U.S. Environmental Protection Agency

Washington, DC

March 1, 2014

### Draft for Comment Version

– March 1, 2014



### 2 Appendix Table B1: Inhalation Equivalent Concentration Calculations

Chemical Species: Strain NOAEL

(mg/kg/day) A CF D (hours) AF IEC

(mg/L) IEC

(ug/m3)

2,4

- DB Rat: SD 31 1 43.5 6 1 0.1188 118774

Abamectin Rat: SD 0.12 1 43.5 6 1 0.0005 460

Acequinocyl Rabbit 60 1 22.8 6 1 0.4386 438596

Acequinocyl Rabbit 60 1 22.8 6 1 0.4386 438596

Acetochlor Rat: SD 150 1 43.5 6 1 0.5747 574713

A cibenzolar Rat: SD 8.2 1 43.5 6 1 0.0314 31418

Alachlor Rat: SD 150 1 43.5 6 1 0.5747 574713

Aliette Rat: SD 300 1 43.5 6 1 1.1494 1149425

Ametryn Rabbit 10 1 22.8 6 1 0.0731 73099

Amicarbazone Dog 6.28 1 32.6 6 1 0.0321 32106

Atrazine Rat: Wistar 6.25 1 45.2 6 1 0.0230 23046

Azoxystrobin Rat: Wistar 25 1 45.2 6 1 0.0922 92183

Benfluralin Rabbit 100 1 22.8 6 1 0.7310 730994

Bensulfuron

- Methyl Dog 19.9 1 32.6 6 1 0.1017 101738

Bensulide Rat: SD 5.5 1 43.5 6 1 0.0211 21073

Bentazon Rat: Wistar 100 1 45.2 6 1 0.3687 368732

Bifenthrin Rat: Long Evans 3 1 44.2 6 1 0.0113 11312

Bispyribac

- sodium Rabbit 100 1 22.8 6 1 0.7310 730994

Boscalid Dog 21.8 1 32.6 6 1 0.1115 111452

Bromacil Rat: SD 20 1 43.5 6 1 0.0766 76628

Bromoxynil Rat: SD 4 1 43.5 6 1 0.0153 15326

Buprofezin Rat: SD 13 1 43.5 6 1 0.0498 49808

Butylate Rat: SD 40 1 43.5 6 1 0.1533 153257

Carfentrazone

- ethyl Rat: SD 50 1 43.5 6 1 0.1916 191571

Chlorfenapyr Dog 3.9 1 32.6 6 1 0.0199 19939

Chlorpropham Dog 5 1 32.6 6 1 0.0256 25562

Chlorsulfuron Rabbit 75 1 22.8 6 1 0.5482 548246

Clethodim Rat: SD 100 1 43.5 6 1 0.3831 383142

Clodinafop

- propargyl Rat: SD 5 1 43.5 6 1 0.0192 19157

Clofencet Dog 5 1 32.6 6 1 0.0256 25562

Clofentezine Rat: SD 2 1 43.5 6 1 0.0077 7663

clomazone Rat: SD 100 1 43.5 6 1 0.3831 383142

Clopyralid Rat: Fischer 344 75 1 47 6 1 0.2660 265957

Clothianidin Rat: SD 9.8 1 43.5 6 1 0.0375 37548

Cyazofamid Rat: SD 100 1 43.5 6 1 0.3831 383142

Cyclanilide Rat: SD 4 1 43.5 6 1 0.0153 15326

Cyflumetofen Rat: Fischer 344 16.5 1 47 6 1 0.0585 58511

Cyhalofop

- butyl Mouse 4.3 1 69.5 6 1 0.0103 10312

### Draft for Comment Version

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### 3 Appendix Table B1: Inhalation Equivalent Concentration Calculations

Chemical Species: Strain NOAEL

(mg/kg/day) A CF D (hours) AF IEC

(mg/L) IEC

(ug/m3)

Cyproconazole Rabbit 2 1 22.8 6 1 0.0146 14620

C yprodinil Rat: SD 62 1 43.5 6 1 0.2375 237548

Daminozide Rat: SD 0.8 1 43.5 6 1 0.0031 3065

DCNA Dog 2.5 1 32.6 6 1 0.0128 12781

Deltamethrin Rat: Long Evans 1 1 44.2 6 1 0.0038 3771

Desmedipham Rat: Wistar 10 1 45.2 6 1 0.0369 36873

Dicamba Rat: SD 45 1 43.5 6 1 0.1724 172414

Difenoconazole Rat: SD 1.25 1 43.5 6 1 0.0048 4789

Dimethenamid Rat: SD 25 1 43.5 6 1 0.0958 95785

Dimethomorph Rat: SD 60 1 43.5 6 1 0.2299 229885

Diuron Rat: SD 58.7 1 43.5 6 1 0.2249 224904

Dodine Rat: SD 10 1 43.5 6 1 0.0383 38314

Emmamectin benoazate Mouse 0.75 1 69.5 6 1 0.0018 1799

Endothall Rat: SD 9.4 1 43.5 6 1 0.0360 36015

Ethalfluralin Rat: Fischer 344 12.5 1 47 6 1 0.0443 44326

Ethofumesate Rabbit 30 1 22.8 6 1 0.2193 219298

Ethoprop Rat: Wistar 0.14 1 45.2 6 1 0.0005 516

Etoxazole Dog 4.62 1 32.6 6 1 0.0236 23620

Fenamidone Rat: SD 10.4 1 43.5 6 1 0.0398 39847

Fenarimol Rat: Wistar 35 1 45.2 6 1 0.1291 129056

Fenazaquin Rat: SD 10 1 43.5 6 1 0.0383 38314

Fenbuconazole Rat: SD 5.1 1 43.5 6 1 0.0195 19540

Fenbutatin

- oxide (Vendex) Rat: SD 5.1 1 43.5 6 1 0.0195 19540

Fenpropathrin Rat: Long Evans 5 1 44.2 6 1 0.0189 18854

Ferbam Rat: Wistar 1.5 1 45.2 6 1 0.0055 5531

Flazasulfuron Dog 2 1 32.6 6 1 0.0102 10225

Flonicamid Rat: Wistar 12 1 45.2 6 1 0.0442 44248

Florasulam Dog 5 1 32.6 6 1 0.0256 25562

Florasulam Dog 5 1 32.6 6 1 0.0256 25562

Flubendiamide Dog 2.6 1 32.6 6 1 0.0133 13292

Fludioxonil Rabbit 10 1 22.8 6 1 0.0731 73099

Flufenacet Rat: SD 1.7 1 43.5 6 1 0.0065 6513

Flumetralin Dog 11.6 1 32.6 6 1 0.0593 59305

Flumetsulam Dog 100 1 32.6 6 1 0.5112 511247

Flumeturon Rat: SD 10 1 43.5 6 1 0.0383 38314

Flumiclorac

- pentyl Dog 100 1 32.6 6 1 0.5112 511247

Flumioxazan Rat: SD 3 1 43.5 6 1 0.0115 11494

Fluometuron Rat: SD 10 1 43.5 6 1 0.0383 38314

Fluopicolide Rabbit 20 1 22.8 6 1 0.1462 146199

### Draft for Comment Version

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### 4 Appendix Table B1: Inhalation Equivalent Concentration Calculations

Chemical Species: Strain NOAEL

(mg/kg/day) A CF D (hours) AF IEC

(mg/L) IEC

(ug/m3)

Fluoxastrobin Dog 3 1 32.6 6 1 0.0153 15337

Fluroxypyr Rat: SD 100 1 43.5 6 1 0.3831 383142

Fluthiacet

- methyl Mouse 1.3 1 69.5 6 1 0.0031 3118

Flutriafol Rabbit 7.5 1 22.8 6 1 0.0548 54825

Folpet Rabbit 10 1 22.7 6 1 0.0734 73421

Fomesafen Rat: Wistar 0.5 1 45.2 6 1 0.0018 1844

Formetanate Rat: Long Evans 0.032 1 44.2 6 1 0.0001 121

Halosulfuron

- Methyl Rabbit 50 1 22.8 6 1 0.3655 365497

Hexazinone Rabbit 50 1 22.8 6 1 0.3655 365497

Hexythiazox Rat: Fischer 344 30 1 47 6 1 0.1064 106383

Imazamethabenz Dog 25 1 32.6 6 1 0.1278 127812

Imazapic Rabbit 350 1 22.8 6 1 2.5585 2558480

Imazapic Rabbit 350 1 22.8 6 1 2.5585 2558480

Imazapyr Dog 250 1 32.6 6 1 1.2781 1278119

Imazaquin Dog 25 1 32.6 6 1 0.1278 127812

Imazethapyr Rabbit 300 1 22.8 6 1 2.1930 2192982

Imidacloprid Rat: SD 10 1 43.5 6 1 0.0383 38314

Indaziflam Dog 7.5 1 32.6 6 1 0.0383 38344

Iodosulfuron

- methyl Dog 49 1 32.6 6 1 0.2505 250511

Iprodione Rat: SD 50 1 43.5 6 1 0.1916 191571

Isoxaben Rat: Wistar 200 1 45.2 6 1 0.7375 737463

Kasugamycin Rabbit 10 1 22.8 6 1 0.0731 73099

Lactofen Rabbit 5 1 22.8 6 1 0.0365 36550

Linuron Rat: SD 5.8 1 43.5 6 1 0.0222 22222

Mandipropamid Rat: SD 41 1 45.2 6 1 0.1512 151180

MCPA Rat: SD 4.4 1 45.2 6 1 0.0162 16224

MCPB Rabbit 5 1 22.8 6 1 0.0365 36550

Mepiquat

- Chloride Dog 58.4 1 32.6 6 1 0.2986 298569

Mesotrione Rat: SD 100 1 43.5 6 1 0.3831 383142

Metaflumizone Rat: Wistar 20 1 45.2 6 1 0.0737 73746

Metalaxyl Rat: SD 40 1 43.5 6 1 0.1533 153257

Metaldehyde Dog 30 1 32.6 6 1 0.1534 153374

Metconazole Fischer 6.4 1 47 6 1 0.0227 22695

Methidathion Rat: SD 0.2 1 45.2 6 1 0.0007 737

Methoxyfenozide Dog 16.8 1 32.6 6 1 0.0859 85890

Metolachlor Rat: SD 50 1 43.5 6 1 0.1916 191571

Metrafenone Rat: SD 79 1 43.5 6 1 0.3027 302682

Metsulfuron Rat: SD 34 1 43.5 6 1 0.1303 130268

Metsulfuron Rat: SD 34 1 43.5 6 1 0.1303 130268

### Draft for Comment Version

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### 5 Appendix Table B1: Inhalation Equivalent Concentration Calculations

Chemical Species: Strain NOAEL

(mg/kg/day) A CF D (hours) AF IEC

(mg/L) IEC

(ug/m3)

M yclobutinol Rat: SD 10 1 43.5 6 1 0.0383 38314

Napropamide Rat: SD 30 1 43.5 6 1 0.1149 114943

Nicosulfuron Dog 125 1 32.6 6 1 0.6391 639059

Nitrapyrin Rabbit 10 1 22.8 6 1 0.0731 73099

Norflurazon Rabbit 10 1 22.8 6 1 0.0731 73099

Novaluron Rat: SD 4.38 1 43.5 6 1 0.0168 16782

Novaluron Rat: SD 4.38 1 43.5 6 1 0.0168 16782

Orthosulfamuron Rat: Wistar 88.6 1 45.2 6 1 0.3267 326696

O ryzalin Rabbit 25 1 22.7 6 1 0.1836 183554

Oxyflourfen Rabbit 30 1 22.7 6 1 0.2203 220264

P araquat dichloride Rat: SD 1.25 1 43.5 6 1 0.0048 4789

PBO Rat: SD 630 1 43.5 6 1 2.4138 2413793

PCNB Rat: Wistar 1 1 45.2 6 1 0.0037 3687

PCNB Rat: SD 1 1 43.5 6 1 0.0038 3831

Pendimethalin Rat: SD 10 1 43.5 6 1 0.0383 38314

Penoxsulam Dog 17.8 1 32.6 6 1 0.0910 91002

Phenmedipham Rat: Wistar 24 1 45.2 6 1 0.0885 88496

Phorate Rat: SD 0.25 1 43.5 6 1 0.0010 958

Phosmet Rat: SD 0.6 1 43.5 6 1 0.0023 2299

Picloram Rat: Fischer 344 50 1 47 6 1 0.1773 177305

Primisulfuron

- methyl Rat: SD 50 1 43.5 6 1 0.1916 191571

prodiamine Rat: SD 7.2 1 43.5 6 1 0.0276 27586

Prohexadione calcium Rabbit 40 1 22.8 6 1 0.2924 292398

Prometryn Rabbit 12 1 22.8 6 1 0.0877 87719

Pronamide Rabbit 8.46 1 22.8 6 1 0.0618 61842

Propachlor Rat: SD 175 1 43.5 6 1 0.6705 670498

Propamocarb Rat: SD 65.41 1 43.5 6 1 0.2506 250613

Propanil Rat: SD 9 1 43.5 6 1 0.0345 34483

Propazine Rat: Wistar 6.25 1 45.2 6 1 0.0230 23046

Propiconazole Rat: Wistar 30 1 45.2 6 1 0.1106 110619

Propoxycarbazone

- sodium Rabbit 100 1 22.8 6 1 0.7310 730994

Prosulfuron Dog 5.3 1 32.6 6 1 0.0271 27096

Prothioconazole Rabbit 2 1 22.8 6 1 0.0146 14620

Pymetrozine Rat: SD 8.1 1 43.5 6 1 0.0310 31034

Pyraflufen

- ethyl Rabbit 20 1 22.8 6 1 0.1462 146199

Pyrasulfotole Rat: Wistar 1 1 45.2 6 1 0.0037 3687

Pyridalyl Rat: SD 2.8 1 43.5 6 1 0.0107 10728

Pyridate Dog 20 1 32.6 6 1 0.1022 102249

Pyrimethanil Rat: SD 23.1 1 43.5 6 1 0.0885 88506

### Draft for Comment Version

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### 6 Appendix Table B1: Inhalation Equivalent Concentration Calculations

Chemical Species: Strain NOAEL

(mg/kg/day) A CF D (hours) AF IEC

(mg/L) IEC

(ug/m3)

Pyrithiobac Rat: SD 58.7 1 43.5 6 1 0.2249 224904

Pyroxsulam Mouse 100 1 69.5 6 1 0.2398 239808

Q uinclorac Rabbit 75 1 22.8 6 1 0.5482 548246

Quinoxyfen Rat: SD 20 1 43.5 6 1 0.0766 76628

Quizalofop Rat: SD 0.9 1 43.5 6 1 0.0034 3448

Rimsulfuron Dog 6.25 1 32.6 6 1 0.0320 31953

Saflufenacil Rat: SD 5 1 43.5 6 1 0.0192 19157

Simazine Rat: Wistar 6.25 1 45.2 6 1 0.0230 23046

Sodium Acifluorfen Rat: SD 20 1 43.5 6 1 0.0766 76628

Spinetoram Dog 2.49 1 32.6 6 1 0.0127 12730

Spinosad Dog 2.49 1 32.6 6 1 0.0127 12730

Spirodiclofen Dog 8.4 1 32.6 6 1 0.0429 42945

Spirodiclofen Dog 8.4 1 32.6 6 1 0.0429 42945

Spirotetramat Rabbit 10 1 22.8 6 1 0.0731 73099

Sulfentrazone Rat: SD 10 1 43.5 6 1 0.0383 38314

Sulfosate Dog 25 1 32.6 6 1 0.1278 127812

S ulfosulfuron Rat: SD 24 1 43.5 6 1 0.0920 91954

Tebuconazole Rat: SD 8.8 1 43.5 6 1 0.0337 33716

Tebufenozide Dog 2 1 32.6 6 1 0.0102 10225

Tembotrione Rat: Wistar 0.8 1 45.2 6 1 0.0029 2950

Tepraloxydim Rat: SD 40 1 43.5 6 1 0.1533 153257

Terbacil Rat: SD 2 1 43.5 6 1 0.0077 7663

Thiabendazole Rat: SD 10 1 43.5 6 1 0.0383 38314

Thiamethoxam Rat: Wistar 1.2 1 45.2 6 1 0.0044 4425

Thiazopyr Dog 2 1 32.6 6 1 0.0102 10225

Thidiazuron Rabbit 25 1 22.8 6 1 0.1827 182749

Thiencarbazone Dog 159 1 32.6 6 1 0.8129 812883

Thifensulfuron methyl Rat: Wistar 7 1 45.2 6 1 0.0258 25811

Thiobencarb Rat: SD 2 1 43.5 6 1 0.0077 7663

Thiophanate

- methyl Rabbit 10 1 22.8 6 1 0.0731 73099

Topramezone Rat: Wistar 0.4 1 45.2 6 1 0.0015 1475

Topramezone Rat: Wistar 0.4 1 45.2 6 1 0.0015 1475

Tralkoxydim Rat: Wistar 30 1 45.2 6 1 0.1106 110619

Triadimefon Rat: Wistar 3.4 1 45.2 6 1 0.0125 12537

Triallate Rabbit 5 1 22.8 6 1 0.0365 36550

Triasulfuron Rat: SD 100 1 43.5 6 1 0.3831 383142

Tribenuron methyl Rabbit 20 1 22.8 6 1 0.1462 146199

Triclopyr Rat: SD 5 1 43.5 6 1 0.0192 19157

Trifloxystrobin Rat: SD 3.8 1 43.5 6 1 0.0146 14559

### Draft for Comment Version

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### 7 Appendix Table B1: Inhalation Equivalent Concentration Calculations

Chemical Species: Strain NOAEL

(mg/kg/day) A CF D (hours) AF IEC

(mg/L) IEC

(ug/m3)

Trifloxysulfuron

- sodium Rabbit 100 1 22.8 6 1 0.7310 730994

Triflumizole Rat: SD 3.5 1 43.5 6 1 0.0134 13410

T riflusulfuron Rat: SD 6.56 1 43.5 6 1 0.0251 25134

Trinexapec

- ethyl Rabbit 60 1 22.8 6 1 0.4386 438596

Uniconazole Rat: SD 5 1 43.5 6 1 0.0192 19157

Vinclozolin Rat: Long Evans 3 1 44.2 6 1 0.0113 11312

Zoxamide Dog 48 1 32.6 6 1 0.2454 245399

NOAEL = No Observed Adverse Effect Level

A = Absorption

– ratio of deposition and absorption in the respiratory tract compared to absorption by the oral route

(assumed to be equal)

CF = Conversion factor which accounts for respiratory volume and body weight for a given species/strain

D = Duration of exposure f or animal

AF = Activity factor (default is 1)

IEC = Inhalation equivalent concentration