Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov

United States Prevention, Pesticides March 2010 

 Environmental Protection and Toxic Substances 

 Agency (7510P) 

 

Decyl Isononyl Dimethyl Ammonium 

Chloride (DIDAC) Summary Document: 

Registration Review 

Docket Number: EPA-HQ-OPP-2010-0005 

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TABLE OF CONTENTS 

Decyl Isononyl Dimethyl Ammonium Chloride (DIDAC) 

Registration Review Team ............................................................................................... 4 

I. PRELIMINARY WORK PLAN – DIDAC................................................................. 5 

II. FACT SHEET ............................................................................................................ 19 

III. GLOSSARY of TERMS & ABBREVIATIONS ................................................... 23 

IV. APPENDIX A............................................................................................................ 25 
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DIDAC Registration Review Team 

Human Health & Environmental Effects 

Tim McMahon 

Srinivas Gowda 

Risk Management

Monisha Harris 

Lance Wormell 

Office of General Counsel

Philip Ross 
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I. PRELIMINARY WORK PLAN – Decyl Isononyl Dimethyl Ammonium Chloride 

(DIDAC) 

Introduction

The Food Quality Protection Act (FQPA) of 1996 mandated the registration 

review program. All pesticides distributed or sold in the United States generally must be 

registered by the U.S. Environmental Protection Agency (USEPA, EPA, or the Agency), 

based on scientific data showing that they will not cause unreasonable risks to human 

health or the environment when used as directed on product labeling. The registration 

review program is intended to make sure that, as the ability to assess risk evolves and as 

policies and practices change, all registered pesticides continue to meet the statutory 

standard of no unreasonable adverse effects to human health or the environment. Changes 

in science, public policy, and pesticide use practices will occur over time. Through the 

registration review program, the Agency periodically reevaluates pesticides to make sure 

that as change occurs, products in the marketplace can be used safely. Information on 

this program is provided at http://www.epa.gov/oppsrrd1/registration_review/. 

The Agency is implementing the registration review program pursuant to Section 

3(g) of the Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA) and will review 

each registered pesticide every 15 years to determine whether it continues to meet the 

FIFRA standard for registration. The Agency will consider benefits information and data 

as required by FIFRA. The public phase of registration review begins when the initial 

docket is opened for each case. The docket is the Agency’s opportunity to state what it 

knows about the pesticide and what additional risk analyses and data or information it 

believes are needed to make a registration review decision. After reviewing and 

responding to comments and data received in the docket during this initial comment 

period, the Agency will develop and commit to a final work plan and schedule for the 

registration review of Decyl Isononyl Dimethyl Ammonium Chloride (DIDAC). 

DIDAC (PC Code 069207) is known by the trade name Bardac 2180. Bardac 

2180 is also known by the chemical name of isobardac. DIDAC is considered 

structurally similar to Didecyl Dimethyl Ammonium Chloride (DDAC) (PC Code 

069149) and data developed for DDAC were used to support the initial registration of 

DIDAC in 1995. DDAC, as well as Alkyl Dimethyl Ethyl Ammonium Bromide, Octyl 

Decyl Dimethyl Ammonium Chloride, and Dioctyl Dimethyl Ammonium Chloride are 

structurally similar and are collectively referred to as the Group I "quaternary 

compounds" or "quats" as published in PR Notice 88-2 on 2/26/88. Therefore, the 

Agency will continue to use information from the DDAC database to support the DIDAC 

registration review. Because DIDAC was first registered after November 1, 1984, a 

reregistration eligibility decision (RED) was not issued. A RED was issued in 2006 for 

DDAC. 

Currently, there are six active products for the active ingredient (AI) DIDAC. 

Registered products contain between 10 and 80% AI. Products containing DIDAC are 

registered for use in/on agricultural premises and equipment, food handling/storage 
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establishment premises and equipment, commercial, institutional and industrial premises 

and equipment, residential and public access premises, materials and preservatives, 

medical premises and equipment, industrial processes and water systems, antifouling 

coatings, wood preservatives, swimming pools, and aquatic areas. DIDAC products are 

also registered for use as disinfectants, sanitizers, fungicides, wood preservatives, and 

water treatment microbiocides (for cooling towers, pools and spas, oil field flood waters, 

and pulp and paper mills), and for use in swimming pools and spas as an algaecide, 

industrial water cooling systems (recirculating/once-through, evaporative condensers, 

heat exchange water systems, commercial and industrial cooling towers, influent systems 

such as flow-through filters and lagoons, industrial water scrubbing systems and brewery 

pasteurizers) and pulp/paper mills for control of algae and slime, and as a slimicide in the 

manufacture of paper and paperboard that does not contact food. 

Risk Assessment Status & Anticipated Data Needs

Human Health Risk Assessment Status and Anticipated Data Needs 

The Agency reviewed the hazard and exposure databases for the DIDAC 

registration review case and anticipates that additional toxicity and exposure studies will 

be needed for registration review. The Agency will need to conduct occupational 

inhalation and dermal risk assessments based on exposure to DIDAC through use in 

antifouling coatings. The Agency will need to conduct a dietary assessment based on 

indirect dietary exposure. There will also be a need for drinking water assessment of 

DIDAC based on the materials preservatives, and industrial slimicides use in 

recirculating cooling water towers and paper mills that potentially pass through waste 

water treatment plants and may be discharged into terrestrial and aquatic environments. 

Dietary and Drinking Water Assessment

Dietary Exposure 

 Because DIDAC products are registered for use in/on agricultural premises and 

equipment and food handling/storage establishment premises and equipment, there is the 

potential for dietary exposure to DIDAC through indirect food contact. A dietary 

assessment was conducted for DDAC for the 2006 DDAC RED. No risk of concern was 

identified in the RED; however, confirmatory data were required. Based on the review of 

the confirmatory data, the Agency anticipates reviewing the dietary risk assessment used 

to support the 2006 DDAC RED and, if necessary, will update the assessment to address 

potential exposure to DIDAC. 

Drinking Water Exposure 

DIDAC end-use registrations that could potentially impact water are registrations 

for use as an algaecide and for control of algal and bacterial slimes in once-through water 

cooling towers, and pulp and paper mills. The current indoor uses of DIDAC are 

expected to result in minimal residues in drinking water supplied by residential wells or 
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municipal sources because re-circulating water cooling towers are expected to have 

infrequent discharges and the effluents from recirculating cooling towers are regulated by 

NPDES permits. 

Tolerances

 Quaternary ammonium compounds have a tolerance exemption in 40 CFR 

180.940 (a) as a food contact sanitizer for use in public eating places, in dairy processing 

equipment, and in food processing plants on equipment and utensils and (c) as a food 

contact sanitizer for use in food processing plants on equipment and utensils. 

Aggregate and Cumulative Exposure

 In examining aggregate exposure, EPA takes into account the available and 

reliable information concerning exposures to pesticide residues in food and drinking 

water, as well as non-occupational pesticide exposures. Based on current use patterns, an 

aggregate risk assessment will be needed for DIDAC for dietary (food and drinking 

water) and residential exposure. 

 Section 40(b)(2)(D)(v) of FFDCA requires that, when considering whether to 

establish, modify, or revoke a tolerance, the Agency considers “available information” 

concerning the cumulative effects of a particular pesticide’s residues and “other 

substances that have a common mechanism of toxicity. The Agency has not made a 

common mechanism of toxicity determination for DIDAC or other quaternary 

ammonium compounds and DIDAC does not appear to produce a toxic metabolite 

produced by other substances. For the purposes of this registration review, therefore, a 

cumulative assessment for DIDAC will not be performed at this time. 

Occupational and Residential Assessment

The Agency reviewed all available data associated with DIDAC and DDAC and 

has determined that the currently registered uses of DIDAC may result in residential and 

occupational exposure. Exposure and risk assessments were conducted for DDAC to 

support the 2006 DDAC RED. The Agency anticipates updating these assessments as 

appropriate to include all registered uses of DIDAC including those such as the 

antifoulant coating use that were not applicable for DDAC and, thus, not included in the 

2006 assessment. The Agency anticipates needing exposure studies to properly assess 

exposure to DIDAC in antifouling coatings. 

Anticipated Human Health Data Needs

The Agency anticipated needing the following toxicity and exposure studies to 

assess the DIDAC registration review case: 

Anticipated Human Health Toxicity Data Needs

o (GLN 870.3465) 90-day Inhalation Toxicity Study 
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Anticipated Occupational/Residential Exposure Data Needs

As noted in the DDAC RED, “The risk assessment noted deficiencies in the 

surrogate dermal and inhalation exposure data available from the Chemical 

Manufacturers Association (CMA) data base. Therefore, the Agency is requiring 

confirmatory data to support the uses assessed with the CMA exposure data within this 

risk assessment. The risk assessment also noted that many of the use parameters (e.g., 

amount handled and duration of use) were based on professional judgments. Therefore, 

descriptions of human activities associated with the uses assessed are required as 

confirmatory.” Based on the review of the confirmatory data, the Agency anticipates 

reviewing the occupational/residential exposure assessment used to support the 2006 

DDAC RED and, if necessary, will update the assessment to address potential exposure 

to DIDAC. 

The Agency anticipates needing the data identified below, for DIDAC. 

o (GLN 875.1200) Dermal Exposure 

o (GLN 875.1400) Inhalation Exposure 

o (GLN 875.1600) Applicator Exposure Monitoring Data Reporting 

o (GLN 875.2300) Fabric Leaching Study 

o (GLN 875.2300) Surface Wood Wipe Study 

o (GLN 875.2800) Description of Human Activity (all uses) 

o (GLN 875.2900) Data Reporting and Calculations 

Anticipated Residue Chemistry Data Needs

o (GLN 860.1460) Food Handling* 

*Dietary-Residues in Food from Treating Countertops with DIDAC (FDA Wipe Study 

Methodology) (FDA, 2003a and 2003b) 

Further information and detailed justifications for the studies that are expected to 

be required are available in “Summary of Human Health Effects Data for the Decyl 

Isononyl Dimethyl Ammonium Chloride (DIDAC) Registration Review Decision 

Document,” dated March 26, 2010.

Product Chemistry Status and Anticipated Data Needs 

The data submitted pertaining to the physical and chemical characteristics of the 

active ingredient DIDAC are adequate. All product chemistry data requirements have 

been fulfilled for the active ingredient DIDAC. Therefore, the Agency does not anticipate 

the need to require additional product chemistry data for DIDAC at this time. 

For further information please refer to the Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the Decyl Isononyl Dimethyl Ammonium 

Chloride Registration Review Decision Document, dated March 29, 2010. 
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Environmental Fate and Ecological Risk Assessment Status and Anticipated Data 

Needs

The Agency has evaluated the available environmental fate and ecological effects 

data on DDAC submitted by the registrant. When DIDAC was first registered in 1995, 

the Agency concluded that the chemical structures of DDAC and DIDAC are structurally 

similar; therefore, the environmental fate and ecological effects studies developed on 

DDAC will be used to evaluate DIDAC as part of this registration review. The Agency 

will complete the environmental fate and ecological hazard risk assessments presented 

below. 

• Environmental fate 

• Ecological hazard 

• Endangered species assessment 

Further information and detailed justification for the studies that are expected to 

be required are available in the document titled, Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the Decyl Isononyl Dimethyl Ammonium 

Chloride Registration Review Decision Document, dated March 29, 2010. 

Environmental fate and ecological risk assessments have not been conducted for 

DIDAC. DIDAC uses that have potential for environmental exposure are swimming 

pools water, material preservatives, industrial slimicides used in recirculating water 

cooling towers, and paper mills discharges. The Agency needs to conduct environmental 

fate and ecological risk assessments for swimming pools water, material preservatives, 

and industrial slimicides used in recirculating water cooling towers and paper mills that 

potentially pass through waste water treatment plants (WWTPs) and may be discharged 

into terrestrial and aquatic environments. Also, the Agency needs to conduct an 

ecological risk assessment for DIDAC used in once-through water cooling towers for 

control of microbiological growth and that likely would be discharged into effluents and 

surface waters. The Agency also needs to conduct an ecological risk assessment for 

DIDAC used in aquatic areas to control or kill slime-forming bacteria, fungi, or algae. In 

addition, the Agency needs to conduct an ecological risk assessment for DIDAC used in 

wood preservatives and antifouling coatings. Therefore, the Agency anticipates requiring 

the identified environmental fate and ecotoxicity data for DIDAC and/or any of its major 

degradation products that are of potential concern for all registered uses of DIDAC. 

Anticipated Environmental Fate Data Needs (Indoor Use) 

o (GLN 850.6800) modified activated sludge respiration inhibition 

o (GLN 835.1110) activated sludge sorption isotherm 

Anticipated Ecological Data Needs (Indoor Use) 

o (GLN 850.4225) seedling emergence, Tier II - dose response study on rice 

(Oryza sativa) 
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o (GLN 850.4250) vegetative vigor, Tier II - dose response study on rice 

(Oryza sativa) 

o (GLN 850.4400) aquatic plant growth (aquatic vascular plant toxicity), 

Tier II - dose response study on floating macrophyte Lemna gibba 

o (GLN 850.5400) aquatic plant growth (algal toxicity), Tier II - dose 

response studies on Anabaena flos- aquae (blue-green cyanobacteria), 

Navicula pelliculosa (freshwater diatom), and Skeletonema costatum 

(marine diatom) 

Anticipated Ecological Effects and Environmental Fate Data Requirements for 

Antifoulant Coatings Uses of DIDAC 

 For use in this registration review, the following ecological effects and 

environmental fate data are anticipated as being needed: 

Anticipated Ecological Effects Data Needs (Outdoor Use): 

Guideline Description of Anticipated Data Requirement

Number

850.1045: Acute Penaeid; 

850.1300: Daphnid chronic toxicity test; 

850.1350: Mysid chronic toxicity test - Aquatic invertebrate life cycle 

850.1400: Fish early-life stage toxicity studies 

850.4225: Seedling emergence 

850.4250: Vegetative vigor 

850.4400: Aquatic plant growth using floating macrophyte Lemna gibba 

850.5400: Aquatic plant growth (algal and aquatic plant toxicity) - Tier II 

850.1735: Whole sediment, acute invertebrates (freshwater) 

850.1740: Whole sediment; acute invertebrates (estuarine/marine) 

850.1500: Fish (freshwater and/or estuarine/marine species) life cycle study 

850.1710: Oyster BCF 

850.1730: Fish BCF 

850.1850: Aquatic organism bioavailability/biomagnifications, toxicity tests 

850.1950: Field testing for aquatic organisms (estuarine/marine) 

850.2300: Avian reproductive studies with bobwhite quail and/or mallard duck 

850.4300: Terrestrial Plants Field Study 

850.4450: Aquatic Plants Field Study 

 None: (Special study) Whole sediment - chronic invertebrates (freshwater and/or 

estuarine/marine) 

Anticipated Environmental Fate Data Needs (Outdoor Use): 

Guideline Description of Anticipated Data Requirement

Number

835.6200: Aquatic (sediment) Field Dissipation 

None: (Special study) Special leaching study (ASTM 6903-07) 

None: (Special study) Monitoring of representative U. S. waters (residue of 

concern) 
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Anticipated Ecological Effects and Environmental Fate Data Requirements for 

Outdoor Wood Preservative Uses of DIDAC 

 For DIDAC registered for treatment of wood products used in outdoor scenarios 

(e.g., decks, decking materials, aquatic uses), the Agency anticipates requiring the 

following data in order to conduct the environmental fate and ecological risk 

assessments, including an endangered species assessment. However, note that expected 

data needs may depend on factors such as the quantities of DIDAC (and/or major 

degradates or metabolites) leaching from wood; the types of chemical(s) leaching from 

wood (e.g., parent compound, major degradates or metabolites); the outdoor use 

scenarios in which DIDAC-treated wood may be used; and the Agency's evaluation of 

leaching data along with the available use, effects, and exposure information for DIDAC: 

Anticipated Ecological Effects and Environmental Fate Study Needs1

 For use in this registration review, the following ecological effects and 

environmental fate data are anticipated as being needed: 

Anticipated Ecological Effects Data Needs (Outdoor Use): 

Guideline Description of Anticipated Data Requirement

Number

850.4225: Seedling emergence 

850.4250: Vegetative vigor 

850.4400: Aquatic plant growth using floating macrophyte Lemna gibba 

850.5400: Aquatic plant growth (algal and aquatic plant toxicity) - Tier II 

850.1045: Acute Penaeid 

850.1300: Daphnid chronic toxicity test 

850.1350: Mysid chronic toxicity test 

850.1400: Fish early-life stage toxicity studies 

850.1500: Fish (freshwater and/or estuarine/marine species) life cycle study 

850.1710: Oyster BCF 

850.1730: Fish BCF 

850.1850: Aquatic organism bioavailability/biomagnifications, toxicity tests 

850.1735: Whole sediment, acute invertebrates (freshwater) 

850.1740: Whole sediment; acute invertebrates (estuarine/marine) 

850.1950: Field testing for aquatic organisms (estuarine/marine) 

850.2300: Avian reproductive studies with bobwhite quail and/or mallard duck 

850.3020: Honeybee acute contact LD50

850.3030: Honey Bee Toxicity of Residues on Foliage 

850.4300: Terrestrial Plants Field Study 

850.4450: Aquatic Plants Field Study 

None: (Special study) Whole sediment - chronic invertebrates (freshwater and/or 

estuarine/marine) 

 

1

 Test material for anticipated studies would depend in part on what chemicals are leaching from DIDACtreated wood. 
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Anticipated Environmental Fate Data Needs (Outdoor Use): 

Guideline Description of Anticipated Data Requirement

Number

835.4200: Anaerobic soil metabolism 

835.6200: Aquatic (sediment) Field Dissipation 

None: (Special study) Soil leaching from wood study (AWPA E20-04) 

None: (Special study) Monitoring of representative U. S. waters (residue of 

concern) 

Anticipated Ecological Effects and Environmental Fate Data Requirements for 

Aquatic Areas Use Pattern of DIDAC 

 For use in this registration review, the following ecological effects and 

environmental data are anticipated as being needed: 

Anticipated Ecological Effects Data Needs (Outdoor Use): 

Guideline Description of Anticipated Data Requirement

Number

850.1300 Aquatic invertebrate chronic NOAEC using Daphnia magna 

850.1350 Aquatic invertebrate chronic NOAEC using mysid shrimp 

850.1400: Fish early-life stage and aquatic invertebrate life-cycle 

850.2300: Avian reproductive studies with bobwhite quail and/or mallard duck 

850.4225: Seedling emergence 

850.4250: Vegetative vigor dose response test using rice 

850.4400: Aquatic plant growth using floating macrophyte Lemna gibba - Tier II 

850.5400: Aquatic plant growth (algal and aquatic plant toxicity) - Tier II 

850.1045: Acute Penaeid 

850.1500: Fish (freshwater and/or estuarine/marine species) life cycle study 

850.1710: Oyster BCF 

850.1730: Fish BCF 

850.1850: Aquatic organism bioavailability/biomagnification/toxicity tests 

850.1735: Whole sediment, acute invertebrates (freshwater) 

850.1740: Whole sediment; acute invertebrates (estuarine/marine) 

850.1950: Field testing for aquatic organisms (estuarine/marine) 

850.4300: Terrestrial Plants Field Study 

850.4450: Aquatic Plants Field Study 

None: (Special study) Whole sediment - chronic invertebrates (freshwater and/or 

estuarine/marine) 

Anticipated Environmental Fate Data Needs (Outdoor Use): 

Guideline Description of Anticipated Data Requirement

Number

835.6200: Aquatic (sediment) Field Dissipation 
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None: (Special study) Monitoring of representative U. S. waters (residue of 

concern) 

Anticipated Ecological Effects and Environmental Fate Data Requirements for 

Once-Through Cooling Water Systems Use Pattern of DIDAC 

DIDAC is intended for use in once-through industrial cooling water systems in which the 

water is not re-used, and is released after a single cycle through the system, and therefore, 

the Agency anticipates requiring the following data in order to conduct the environmental 

fate and ecological risk assessments, including an endangered species assessment. 

Anticipated Ecological Effects and Environmental Fate Study Needs

For use in this registration review, the following ecological effects and environmental 

data are anticipated as being needed: 

Anticipated Ecological Effects Data Needs (Outdoor Use): 

Guideline Description of Anticipated Data Requirement

Number

850.1300 Aquatic invertebrate chronic NOAEC using Daphnia magna 

850.1350 Aquatic invertebrate chronic NOAEC using mysid shrimp 

850.1400: Fish early-life stage and aquatic invertebrate life-cycle studies 

850.4225: Seedling emergence 

850.4400: Aquatic plant growth using floating macrophyte Lemna gibba - Tier II 

850.5400: Aquatic plant growth (algal and aquatic plant toxicity) - Tier II 

850.1045: Acute Penaeid 

850.1500: Fish (freshwater and/or estuarine/marine species) life cycle study 

850.1710: Oyster BCF 

850.1730: Fish BCF 

850.1850: Aquatic organism bioavailability/biomagnification/toxicity tests 

850.1735: Whole sediment, acute invertebrates (freshwater) 

850.1740: Whole sediment; acute invertebrates (estuarine/marine) 

850.1950: Field testing for aquatic organisms (estuarine/marine) 

850.2300: Avian reproductive studies with bobwhite quail and/or mallard duck 

850.4250: Vegetative vigor dose response test using rice – Tier II (Oryza sativa) 

850.4300: Terrestrial Plants Field Study 

850.4450: Aquatic Plants Field Study 

None: (Special study) Whole sediment - chronic invertebrates (freshwater and/or 

estuarine/marine) 

Anticipated Environmental Fate Data Needs (Outdoor Use): 

Guideline Description of Anticipated Data Requirement

Number

835.1110: Activated sludge sorption isotherm 

850.6800: Modified activated sludge, respiration inhibition 
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835.6200: Aquatic (sediment) Field Dissipation 

None: (Special study) Monitoring of representative U. S. waters (residue of 

concern) 

Endangered Species 

The Agency has not conducted a risk assessment that supports a complete 

endangered species determination. The ecological risk assessment planned during 

registration review will allow the Agency to determine whether use of DIDAC has “no 

effect” or “may affect” federally listed threatened or endangered species (listed species) 

or their designated critical habitats. When an assessment concludes that a pesticide’s use 

“may affect” a listed species or its designated critical habitat, the Agency will consult 

with the U.S. Fish and Wildlife Service and/or National Marine Fisheries Service (the 

Services), as appropriate. 

Incidents:

As discussed in the DDAC RED, there were many reported incidents associated 

with exposure to end-use products containing quats. However, as also noted, for the 

available incident information, it was difficult to differentiate the specific members of the 

quats involved in each incident. Therefore, all the quats are discussed together. 

Most of the incidents are related to irritation. Allergic type reactions have also 

been reported in some incidents. Symptoms associated with eye irritation are the most 

commonly reported associated with quaternary ammonium exposure. The most common 

symptoms reported for cases of ocular exposure were eye irritation/burning, eye pain, 

conjunctivitis, swelling eye and swelling of eyelid. The most common symptoms 

reported for cases of inhalation exposure were respiratory irritation/burning, irritation to 

mouth/throat/nose, coughing/choking, chest pain, disorientation, dizziness, shortness of 

breath. The most common symptoms reported for cases of dermal exposure were skin 

irritation/burning, rash, itching, and blistering. Allergic type reactions including hives 

and allergic contact dermatitis, have also been reported. Although oral exposure is 

considered a minor route of exposure for quats use, irritation to mouth/throat/nose, 

vomiting/nausea/abdominal pain, dizziness, and headache have been reported in the cases 

of ingestion. 
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Timeline:

EPA has created the following estimated timeline for the completion of the 

DIDAC registration review: 

Anticipated Schedule

Activities Estimated Month/Year

Phase 1: Opening the docket 

Open Public Comment Period for DIDAC Docket March 2010 

Close Public Comment Period May 2010 

Phase 2: Case Development 

Develop Final Work Plan (FWP) September 2010 

Issue DCI September 2011 

Data Submission September 2015 

Open Public Comment Period for Preliminary Risk Assessments March 2016 

Close Public Comment Period June 2016 

Phase 3: Registration Review Decision 

Open Public Comment Period for Proposed Reg. Review Decision September 2016 

Close Public Comment Period December 2016 

Final Decision and Begin Post-Decision Follow-up 2017 

Total (years) 7 

Guidance for Respondents:

The public is invited to comment on EPA’s preliminary registration review work 

plan and rationale. The Agency will carefully consider all comments as well as any 

additional information or data provided in a timely manner prior to issuing a final work 

plan for the DIDAC registration review case. 

Trade Irritants 

Through the registration review process, the Agency intends to solicit information 

on trade irritants and, to the extent feasible, take steps toward facilitating irritant 

resolution. Growers and other stakeholders are asked to comment on any trade irritant 

issues resulting from lack of Maximum Residue Limits (MRLs) or disparities between 

U.S. tolerances and MRLs in key export markets, providing as much specificity as 

possible regarding the nature of the concern. 

Water Quality 

DIDAC is not identified as a cause of impairment for any water bodies listed as 

impaired under section 303(d) of the Clean Water Act, based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation_cy.cause_detail_303d?p_cause_grou

p_id=885. In addition, no Total Maximum Daily Loads (TMDL) have been developed 
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for [insert pesticide], based on information provided at 

http://iaspub.epa.gov/tmdl_waters10/attains_nation.tmdl_pollutant_detail?p_pollutant_gr

oup_id=885&p_pollutant_group_name=PESTICIDES. More information on impaired 

water bodies and TMDLs can be found at http://www.epa.gov/owow/tmdl/. The Agency 

invites submission of water quality data for this pesticide. To the extent possible, data 

should conform to the quality standards in Appendix A of the OPP Standard Operating 

Procedure: Inclusion of Impaired Water Body and Other Water Quality Data in OPP’s 

Registration Review Risk Assessment and Management Process (see: 

http://www.epa.gov/oppsrrd1/registration_review/water_quality_sop.htm) in order to 

ensure they can be used quantitatively or qualitatively in pesticide risk assessments. 

Environmental Justice 

EPA seeks to achieve environmental justice, the fair treatment and meaningful 

involvement of all people, regardless of race, color, national origin, or income, in the 

development, implementation, and enforcement of environmental laws, regulations, and 

policies. To help address potential environmental justice issues, the Agency seeks 

information on any groups or segments of the population who, as a result of their 

location, cultural practices, or other factors, may have atypical, unusually high exposure 

to DIDAC compared to the general population. Please comment if you are aware of any 

sub-populations that may have atypical, unusually high exposure compared to the general 

population. 

Structure Activity Relationships 

EPA must rely upon information of appropriate quality and reliability for each 

decision made by the Agency. In the Office of Pesticide Programs (OPP), the evaluation 

process for a pesticide chemical traditionally begins with the applicant’s submission of a 

set of studies conducted with the specific pesticide chemical of interest. The use of the 

results of such testing (measured data) is a logical, scientifically rigorous process that 

identifies the physical, chemical, and environmental fate properties of the pesticide, as 

well as the dose and endpoints at which an adverse effect can occur in various animal 

species. 

Today, there is significant interest in alternative techniques, i.e., techniques other 

than data generation that could significantly inform the Agency’s decision-making 

process. Recently, OPP has made increasing use of structure activity relationship (SAR) 

as part of its regulatory decision-making process. In the SAR process, a chemical's 

molecular structure is compared to that of other chemicals for which data are available. 

These structural similarities are then used to make predictive judgments about a 

chemical’s physical, chemical, and biological properties. Thus, the chemical’s physical, 

chemical, and biological properties are a function of (or directly related to) the chemical’s 

molecular structure. Quantitative SAR is referred to as QSAR. To develop a QSAR, a 

selected set of measured data on a single physical, chemical, or biological property is 

used to derive a model (an equation) to predict the value of that property. 
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 Since SAR assessments and QSAR modeling are another set of tools that are 

available to Agency scientists, OPP has begun a process shift that envisions shifting from 

the current study-by-study approach to an approach in which the use of predicted data, 

generated using validated models, is considered along with information from open 

literature and studies specifically generated under Part 161 requirements. All relevant 

information would be considered as part of a weight-of-the-evidence evaluation. 

At this time, EPA believes that for certain endpoints, especially physical/chemical 

and fate properties, that SAR and QSAR might be effectively utilized to fulfill these data 

requirements for many antimicrobial pesticide chemicals. When considering biological 

properties, at this time, EPA believes that SAR and QSAR can be most effectively 

utilized in the evaluation of chemicals that exhibit lower toxicity for human health and/or 

ecotoxicity parameters. This is appropriate because the risk assessment for lower toxicity 

chemicals can be stream-lined, i.e., a screening-level assessment procedure rather than 

multiple tiers of assessments with progressively more data requirements. 

If stakeholders believe that submission of predicted data can fulfill one of the data 

needs for DIDAC, then the Agency invites submission of this information. The submitter 

would be expected to supply a rationale describing the utility of the information and 

provide documentation on the scientific validity of the information. The determination 

that the predicted data fulfills the data requirement would be at the sole discretion of the 

Agency. Pre-submission consultation with the Agency is encouraged. 

Endocrine Disruptor Screening Program 

As required under FFDCA section 408(p), EPA has developed the Endocrine 

Disruptor Screening Program (EDSP) to determine whether certain substances (including 

pesticide active and other ingredients) may have an effect in humans or wildlife similar to 

an effect produced by a “naturally occurring estrogen, or other such endocrine effects as 

the Administrator may designate.” The EDSP employs a two-tiered approach to making 

the statutorily required determinations. Tier 1 consists of a battery of 11 screening assays 

to identify the potential of a chemical substance to interact with the estrogen, androgen, 

or thyroid (E, A, or T) hormonal systems. Chemicals that go through Tier 1 screening 

and are found to have the potential to interact with E, A, or T hormonal systems will 

proceed to the next stage of the EDSP where EPA will determine which, if any, of the 

Tier 2 tests are necessary based on the available data. Tier 2 testing is designed to 

identify any adverse endocrine related effects caused by the substance, and establish a 

dose-response relationship between the dose and the E, A, or T effect. 

Between October 2009 and February 2010, EPA issued test orders/data call-ins 

for the first group of 67 chemicals, which contains 58 pesticide active ingredients and 9 

inert ingredients. This list of chemicals was selected based on the potential for human 

exposure through pathways such as food and water, residential activity, and certain postapplication agricultural scenarios. This list should not be construed as a list of known or 

likely endocrine disruptors. 
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DIDAC is not among the group of 58 pesticide active ingredients on the initial list 

to be screened under the EDSP. Under FFDCA sec. 408(p) the Agency must screen all 

pesticide chemicals. Accordingly, EPA anticipates issuing future EDSP test orders/data 

call-ins for all pesticide active ingredients. 

For further information on the status of the EDSP, the policies and procedures, the 

list of 67 chemicals, the test guidelines and the Tier 1 screening battery, please visit our 

website: http://www.epa.gov/endo/. 

Additional Information 

Stakeholders are also specifically asked to provide available information and data 

in the following areas: 

1. Confirmation on the following label information: 

a. Sites of application 

b. Formulations 

c. Application methods and equipment 

d. Maximum application rates 

e. Frequency of application, application intervals and maximum 

number of applications 

f. Geographic limitations on use 

2. Use or potential use distribution 

3. Use history 

4. Usage/use information for non-agricultural uses (e.g., materials 

preservation) 

5. Typical application interval 

6. State or local use restrictions 

7. Ecological incidents (non-target plant damage and avian, fish, 

reptilian, amphibian and mammalian mortalities) not already reported 

to the Agency 

8. Monitoring data 

9. Structure Activity Relationships 

Next Steps: 

After the 60-day comment period closes, the Agency will review and respond to 

any comments received in a timely manner, and then issue a Final Work Plan for 

DIDAC. 
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II. FACT SHEET 

Background Information

• Chemical Name: Decyl Isononyl Dimethyl Ammonium Chloride (DIDAC) 

• Common Names: 1-Decanaminium, N-isononyl-N,N-dimethyl-, chloride 

• Trade Name: Bardac 2180 

• Registration review case number: 5013 

• PC Code: 069207 

• CAS#: 138698-36-9 

• Technical Registrant: Lonza Inc. 

• First approved for use in a registered product: 1995 

• Six active registrations 

• Antimicrobials Division Chemical Review Manager (CRM): Monisha Harris, 

harris.monisha@epa.gov 

• Antimicrobials Division Product Manager (PM): Velma Noble, 

noble.velma@epa.gov 

Chemical Structure:

N+

CH3

R1 CH3

ClR2 

N+

CH3

R CH3

ClR

 DIDAC DDAC 

 R1 = C10H21 (decyl) R = C10H21 (decyl) 

 R2 = Iso-C9H19 (isononyl)
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Use & Usage Information

• Type of Pesticide: algaecide, disinfectant, fungicide, fungicide/fungistat, 

microbicide/microbistat, molluscicide and tadpole shrimp and sanitizer 

• Antimicrobial Use Sites:

o agricultural premises and equipment 

o food handling/storage establishment premises and equipment 

o commercial, institutional and industrial premises and equipment 

o residential and public access premises 

o materials and preservatives 

o medical premises and equipment 

o industrial processes and water systems 

o antifouling coatings 

o wood preservatives 

o swimming pools and aquatic areas. 

o water treatment microbiocides 

 for cooling towers, pools and spas, oil field flood waters, pulp and 

paper mills 

Recent Regulatory Actions

There are no recent regulatory actions for DIDAC. Products containing DIDAC 

was first registered with the EPA on May 11th 1995. 

http://www.epa.gov/pesticides/reregistration/status.htm

Human Health Risk Assessment Status

The Agency reviewed the hazard and exposure databases for the DIDAC 

registration review case and anticipates that additional toxicity and exposure studies will 

be needed for registration review. The EPA anticipates that there is potential 

occupational inhalation and dermal exposure through use of DIDAC in antifouling 

coatings. The Agency will need to conduct a dietary assessment based on indirect dietary 

exposure. There will also be a need for drinking water assessment of DIDAC based on 

the conclusion of the environmental assessment. Further information and detailed 

justifications for the studies that are expected to be required are available in “Summary 

of Human Health Effects Data for the Decyl Isononyl Dimethyl Ammonium Chloride 

(DIDAC) Registration Review Decision Document,” dated March 26, 2010. 
Docket Number: EPA-HQ-OPP-2010-0005 

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 21 of 37 

Environmental Fate & Ecological Risk Assessment Status

 The Agency has reviewed the environmental fate and ecotoxicity databases for 

the DIDAC registration review case and anticipates requiring additional environmental 

fate and ecotoxity data to complete a risk assessment for DIDAC and/or any of its major 

degradation products that are of potential concern for all registered uses of DIDAC. 

The Agency has not conducted a risk assessment that supports a complete 

endangered species determination. The ecological risk assessment planned during 

registration review will allow the Agency to determine whether DIDAC’s use has “no 

effect or “may affect” federally listed threatened or endangered species (listed species) or 

their designed critical habitats. When an assessment concludes that a pesticide’s use 

“may affect” a listed species or its designated critical habitat, the Agency will consult 

with the U.S. Fish and Wildlife Service and/or National Marine Fisheries Services (the 

Services), as appropriate. 

Further information and detailed justification for the studies that are expected to 

be required are available in the document titled, Summary of Product Chemistry, 

Environmental Fate, and Ecotoxicity Data for the Decyl Isononyl Dimethyl Ammonium 

Chloride Registration Review Decision Document, dated March 29, 2010. 

Tolerances 

There are no tolerances or exemptions from tolerances for DIDAC and no 

registered food uses. DDAC has a tolerance exemption in 40 CFR 180.940 (a) as a food 

contact sanitizer for use in public eating places, in dairy processing equipment, and in 

food processing plants on equipment and utensils and 40 CFR 180.940 (c) as a food 

contact sanitizer for use in food processing plants on equipment and utensils.

Data Call-In Status

 

The Agency anticipates requiring additional data to complete a risk assessment 

during the registration review of this case. 

Labels 

There are 6 registered products that contain DIDAC. The EPA registration 

numbers are provided in Table 1 below. For future reference, during registration review 

a list of product registration numbers will be included in the docket. Product registration 

labels may be obtained from the Pesticide Product Label System (PPLS) website at: 

http://oaspub.epa.gov/pestlabl/ppls.home. 
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Table 1. Registered Active Products of DIDAC 

Registration 

 # 

Registration 

Name 

Company 

Name Formulation Type % of Active Ingredient 

6836-209 Bardac 2180 Lonza Inc. Formulation intermediate 80 

6836-218 Bardac RW-10 Lonza Inc. Ready-to-use solution 10 

6836-219 Bardac CW-10 Lonza Inc. Ready-to-use solution 10 

6836-220 Bardac CW-50 Lonza Inc. Ready-to-use solution 50 

6836-221 Bardac RW-50 Lonza Inc. Ready-to-use solution 50 

6836-228 Bardac 2150 LA Lonza Inc. Soluble concentrate for 

Formulating Uses 50 
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 23 of 37 

III. GLOSSARY of TERMS & ABBREVIATIONS

ai Active Ingredient 

AR Anticipated Residue 

ASTM American Society for Testing and Materials 

AWPA American Wood Preserver’s Association 

CFR Code of Federal Regulations 

cPAD Chronic Population Adjusted Dose 

CSF Confidential Statement of Formula 

CSFII USDA Continuing Surveys for Food Intake by Individuals 

DCI Data Call-In 

DEEM Dietary Exposure Evaluation Model 

DFR Dislodgeable Foliar Residue 

DNT Developmental Neurotoxicity 

DWLOC Drinking Water Level of Comparison 

EC Emulsifiable Concentrate Formulation 

EDWC Estimated Drinking Water Concentration 

EEC Estimated Environmental Concentration 

EPA Environmental Protection Agency 

EUP End-Use Product 

FDA Food and Drug Administration 

FIFRA Federal Insecticide, Fungicide, and Rodenticide Act 

FFDCA Federal Food, Drug, and Cosmetic Act 

FQPA Food Quality Protection Act 

FOB Functional Observation Battery 

GENEEC Tier I Surface Water Computer Model 

IR Index Reservoir 

LC50 Median Lethal Concentration. A statistically derived concentration of a 

substance that can be expected to cause death in 50% of test animals. It is 

usually expressed as the weight of substance per weight or volume of water, air 

or feed, e.g., mg/l, mg/kg or ppm. 

LD50 Median Lethal Dose. A statistically derived single dose that can be expected to 

cause death in 50% of the test animals when administered by the route indicated 

(oral, dermal, inhalation). It is expressed as a weight of substance per unit 

weight of animal, e.g., mg/kg. 

LOC Level of Concern 

LOAEL Lowest Observed Adverse Effect Level 

μg/g Micrograms Per Gram 

μg/L Micrograms Per Liter 

mg/kg/day Milligram Per Kilogram Per Day 

mg/L Milligrams Per Liter 

MOE Margin of Exposure 

MRID Master Record Identification (number). EPA's system of recording and tracking 

submitted studies. 

MUP Manufacturing-Use Product 

NA Not Applicable 

NAWQA USGS National Ambient Water Quality Assessment 

NPDES National Pollutant Discharge Elimination System 

NR Not Required 

NOAEL No Observed Adverse Effect Level 

OPP EPA Office of Pesticide Programs 

OPPTS EPA Office of Prevention, Pesticides and Toxic Substances 

PAD Population Adjusted Dose 

PAIRA Pure Active Ingredient Radiolabelled 

PCA Percent Crop Area 

PDP USDA Pesticide Data Program 
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 24 of 37 

PHED Pesticide Handler's Exposure Data 

PHI Preharvest Interval 

ppb Parts Per Billion 

PPE Personal Protective Equipment 

ppm Parts Per Million 

PRZM/EXAMS Tier II Surface Water Computer Model 

Q1* The Carcinogenic Potential of a Compound, Quantified by the EPA's Cancer 

Risk Model 

RAC Raw Agriculture Commodity 

RED Reregistration Eligibility Decision 

REI Restricted Entry Interval 

RfD Reference Dose 

RQ Risk Quotient 

SCI-GROW Tier I Ground Water Computer Model 

SAP Science Advisory Panel 

SF Safety Factor 

SLN Special Local Need (Registrations Under Section 24©) of FIFRA) 

TGAI Technical Grade Active Ingredient 

TEP Typical End-Use Product 

USDA United States Department of Agriculture 

UF Uncertainty Factor 

WPS Worker Protection Standard 
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 25 of 37 

IV. APPENDIX A

Use Patterns for Decyl Isononyl Dimethyl Ammonium Chloride (DIDAC) 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Agricultural Premises and Equipment Agriculture Premises and Equipment 

Formulation Intermediate 6836-209 

Not listed on the label. 

Not listed on the label. This product is a concen

only. This product shouwith any reducing or oxhypochlorite, solid percsuch mixtures may be econjunction with soap oFormulators using this pproviding data for the Eformulated products. Thformulate products for slabel if the formulator ocompiled with U.S. EPA the support of such use(

 Food Handling/Storage Establishments Premises and Equipment Food Handling/Storage Establishments and Equipment 

Formulation Intermediate 6836-209 

Not listed on the label. 

Not listed on the label. This product is a concen

only. This product shouwith any reducing or oxhypochlorite, solid percsuch mixtures may be econjunction with soap oFormulators using this pproviding data for the Eformulated products. Thformulate products for slabel if the formulator ocompiled with U.S. EPA the support of such use(
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 26 of 37 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Commercial, Institutional and Industrial Premises and EquipmentCommercial, Institutional and Industrial Premises and Equipment 

Formulation Intermediate 6836-209 

Not listed on the label.

Not listed on the label. This product is a concen

only. This product shouwith any reducing or oxhypochlorite, solid percsuch mixtures may be econjunction with soap oFormulators using this pproviding data for the Eformulated products. Thformulate products for slabel if the formulator ocompiled with U.S. EPA the support of such use(

Residential and Public Access Premises Residential and Public Access Premises 

Formulation Intermediate 6836-209 

Not listed on the label.

Not listed on the label. This product is a concen

only. This product shouwith any reducing or oxhypochlorite, solid percsuch mixtures may be econjunction with soap oFormulators using this pproviding data for the Eformulated products. Thformulate products for slabel if the formulator ocompiled with U.S. EPA the support of such use(
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 27 of 37 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Medical Premises and Equipment Medical Premises and Equipment 

Formulation Intermediate 6836-209 

Not listed on the label.

Not listed on the label. This product is a concen

only. This product shouwith any reducing or oxhypochlorite, solid percsuch mixtures may be econjunction with soap oFormulators using this pproviding data for the Eformulated products. Thformulate products for slabel if the formulator ocompiled with U.S. EPA the support of such use(

Materials Preservatives Materials Preservatives Formulation 

Intermediate 6836-209 

Not listed on the label.

Not listed on the label. This product is a concen

only. This product shouwith any reducing or oxhypochlorite, solid percsuch mixtures may be econjunction with soap oFormulators using this pproviding data for the Eformulated products. Thformulate products for slabel if the formulator ocompiled with U.S. EPA the support of such use(
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 28 of 37 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Industrial Processes and Water Systems Industrial Processes and Water Systems 

Formulation Intermediate 6836-209 

Not listed on the label. 

Not listed on the label. This product is a concen

only. This product shouwith any reducing or oxhypochlorite, solid percsuch mixtures may be econjunction with soap oFormulators using this pproviding data for the Eformulated products. Thformulate products for slabel if the formulator ocompiled with U.S. EPA the support of such use(

Water Treatment Microbiocides Soluble 

Concentrate 6836-228 

Not listed on the label. 

Not listed on the label. This product is a concen

only. Use only in accordTechnical Bulletin from should not be used or coor oxidizing agents (sucsolid perchlorate, or nitrmany be explosive. Do soap or any anionic wet

Recirculating Water Cooling Systems, Evaporative Condensers, Heat Exchange Water Systems, Commercial and Industrial Cooling Towers, Influent Systems such as Flow Through Filters and Lagoons, Industrial Water Scrubbing Systems and Brewery Pasteurizers, Pulp and Paper Mills, Once Through Cooling Water 

Ready to Use 6836-219 6836-220 

 Feed Pumps, Meters and Feed lines, Sump Dose, Intermittent/Slug Dosing, Continuous Feed 

Recirculating Water Cooling Initial Treatments: For initial treatment apply product to a visually clean system or when algae or slime is first visible. Add 1.5 to 80 fluid ounces of this product for each 1,000 gallons of water (5 to 60 ppm active) in the system to the sump water near pump suction. Repeat initial dose until algae and slime control are evident. 

Pulp and Paper Mill: N

of food-contact paper oOnce Through Coolinin accordance will all en
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 29 of 37 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Recirculating Water Cooling Systems, Evaporative Condensers, Heat Exchange Water Systems, Commercial and Industrial Cooling Towers, Influent Systems such as Flow Through Filters and Lagoons, Industrial Water Scrubbing Systems and Brewery Pasteurizers, Pulp and Paper Mills, Once Through Cooling Water (Continued) 

Ready to use 6836-219 6836-220 

Feed Pumps, Meters and Feed lines, Sump Dose, Intermittent/Slug Dosing, Continuous Feed 

Badly fouled systems should be cleaned before initiating treatment. Maintenance Treatments: The frequency at which additional dosages must be added to control slime and algal growth can only be determined by experience, since each system will vary in water composition and in amounts and types of organisms present. After initial control is achieved, maintenance doses 0.5 to 65 fluid ounces for each 1,000 gallons of water (1.5-50 ppm active) should be provided daily, weekly, or bimonthly as required. The dosage frequency for algae control is typically less than that required for control of bacterial slimes. Biweekly treatment is frequently sufficient to control green algae. Feeding: This product may be fed directly from the drum or diluted with water and fed by a suitable feed system. Dose directly into sump or any other convenient location providing 

good distribution of treatment. 

Pulp and Paper Mill: Nof food-contact paper oOnce Through Coolinin accordance will all en
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 30 of 37 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Recirculating Water Cooling Systems, Evaporative Condensers, Heat Exchange Water Systems, Commercial and Industrial Cooling Towers, Influent Systems such as Flow Through Filters and Lagoons, Industrial Water Scrubbing Systems and Brewery Pasteurizers, Pulp and Paper Mills, Once Through Cooling Water (Continued) 

Ready to use 6836-219 6836-220 

Feed Pumps, Meters and Feed lines, Sump Dose, Intermittent/Slug Dosing, Continuous Feed 

Pulp and Paper Mills: This product can be used as a slimicide in the manufacture of paper and paperboard that does not contact food. Apply 0.05-50 gallons of this product per ton of paper produced. Alternatively, apply 0.05-100 gallons of this product per 100,000 gallons of white water to be treated, which corresponds to a concentration of 0.5-100 ppm active ingredient. Additions of this product should be made at a point in the system where mixing action is good. Once Through Cooling Water: The product may be fed directly from its container, or system. Feed pumps meters and feed lines may be stainless steel, neoprene, glass, plastic or unpigmented fiberglass. Dose directly into the sump, near the inlet to the recirculating pump if possible, or any other convenient location providing good distribution. If deactivation is required, bentonite clay may be 

used. A10 ppm clay to 1 ppm active quaternary ration is typical. 

Pulp and Paper Mill: Nof food-contact paper oOnce Through Coolinin accordance will all en
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 31 of 37 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Recirculating Water Cooling Systems, Evaporative Condensers, Heat Exchange Water Systems, Commercial and Industrial Cooling Towers, Influent Systems such as Flow Through Filters and Lagoons, Industrial Water Scrubbing Systems and Brewery Pasteurizers, Pulp and Paper Mills, Once Through Cooling Water (Continued) 

Ready to use 6836-219 6836-220 

Feed Pumps, Meters and Feed lines, Sump Dose, Intermittent/Slug Dosing, Continuous Feed 

Once Through Cooling Water Initial Treatment: Add 1.4 to 130 fluid ounces of this product for each 10,000 gallons of system cooling water (0.5 to 10 ppm active quaternary). Repeat initial dose until biological control is evident. Maintenance Treatment Intermittent/Slug Dosing: The frequency of maintenance doses can only be determined by experience, since each cooling system will vary in water composition and in amounts and types of organisms present. After initial control has been achieved, maintenance doses of 1.4 to 65 fluid ounces of this product for each 10,000 gallons of system cooling water (0.5 to 5 ppm active quaternary) should be added daily, weekly or monthly as required. Continuous Feed: After initial control has been achieved, apply 0.5 to 65 fluid ounces of this product for each 10,000 gallons of system cooling water (0.2 to 5 ppm active quaternary) to maintain biological control. 

Pulp and Paper Mill: N

of food-contact paper oOnce Through Coolinin accordance will all en
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 32 of 37 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Antifouling Coatings Antifouling Coatings Formulation 

Intermediate 6836-209 

Not listed on the label.

Not listed on the label. This product is a concen

only. This product shouwith any reducing or oxhypochlorite, solid percsuch mixtures may be econjunction with soap oFormulators using this pproviding data for the Eformulated products. Thformulate products for slabel if the formulator ocompiled with U.S. EPA the support of such use(

Wood Preservatives Wood Preservatives Formulation 

Intermediate 6836-209 

Not listed on the label.

Not listed on the label. This product is a concen

only. This product shouwith any reducing or oxhypochlorite, solid percsuch mixtures may be econjunction with soap oFormulators using this pproviding data for the Eformulated products. Thformulate products for slabel if the formulator ocompiled with U.S. EPA the support of such use(
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 33 of 37 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Wood Preservatives Soluble 

Concentrate 6836-228 

Not listed on the label. 

Not listed on the label. This product is a concen

only. Use only in accordTechnical Bulletin from should not be used or coor oxidizing agents (sucsolid perchlorate, or nitrmany be explosive. Do soap or any anionic wet

 Swimming Pools Swimming Pools and Spas Ready to Use 

6836-218 

Add Pools and Spas: For visible 

algae add 0.5 gallons to each 10,000 gallons of water. After 24 hours remove dead algae by cleaning algae still present. Repeat doses as necessary. Initial Treatment: Clean pools and spas. Add 1 quart to each 10,000 gallons of water or ratio thereof. Maintenance additions of 0.25-0.5 quarts per 10,000 gallons should be added every 7days or more frequently depending on water and use. Booster dose of 0.25 quarts per 10,000 gallons should be provided after each rain of consequence. Winterization: Test for proper balance of minerals, pH and presence of metals. Take corrective action if necessary. 

Danger: Corrosive. Caudamage. Do not get in egoggles or face shield ahandling. May be fatal i
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 34 of 37 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Swimming Pools and Spas (Continued) 

Ready to Use 6836-218 

Add Winterization: Superchlorinate 

the pool using recommended winter shock treatment according to label directions. Apply when pool is out of service and allow pump to recirculate a minimum of one hour, preferably several hours overnight. Apply this algaecide directly to the pool water, pouring along the edge of the pool. Use 0.5 gallons per 10,000 gallons of water and allow to circulate 2-4 hours. Clean the pool water line and filter. In areas with severe freezing, drain pool equipment and plumbing lines or use antifreeze recommended for swimming pool plumbing and equipment. Pools without covers or mesh covers may need a second treatment in mid-winter or just prior to freezing. 

Danger: Corrosive. Caudamage. Do not get in egoggles or face shield ahandling. May be fatal i
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 35 of 37 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Swimming Pools and Spas Ready to Use 

6836-221 

Add Pools and Spas: For visible 

algae add 16 fluid ounces to each 10,000 gallons of water or ratio thereof. After 24 hours remove dead algae by cleaning. If algae is still present, repeat doses as necessary. Initial Treatment: Clean pools and spas. Add 8 fluid ounces to each 10,000 gallons of water or ratio thereof. Maintenance additions of 1.5-3.0 fluid ounces per 10,000 gallons should be added every 7 days or more frequently depending on water and use and use factors. A booster dose of 1.5 fluid ounces per 10,000 gallons should be provided after each rain of consequence. Winterization: Test for proper balance of minerals, pH and presence of metals. Take corrective action if necessary. Superchlorinate the pool using recommended winter shock treatment according to label 

directions. Apply when pool is out of service and allow pump to recirculate a minimum of one hour, preferably several hours overnight. 

Danger: Corrosive. Caudamage. Do not get in egoggles or face shield ahandling. May be fatal i
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 36 of 37 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Swimming Pools and Spas Ready to Use 

6836-221 

Add Winterization: Apply this 

algaecide directly to the pool water, pouring along the edge of the pool. Use 13 fluid ounces per 10,000 gallons of water and allow to circulate 2-4 hours. Clean the pool water line and filter. In areas with severe freezing, drain pool equipment and plumbing lines or use antifreeze recommended for swimming pool plumbing and equipment. Pools without covers or mesh covers may need a second treatment in mid-winter or just prior to freezing. 

Danger: Corrosive. Caudamage. Do not get in egoggles or face shield ahandling. May be fatal i
Docket Number: EPA-HQ-OPP-2010-0005 

www.regulations.gov 37 of 37 

Use Site Formulation Method of 

Application 

Application Rate/ No. of 

applications 

Use 

Swimming Pools Formulation 

Intermediate 6836-209 

Not listed on the label. 

Not listed on the label. This product is a concen

only. This product shouwith any reducing or oxhypochlorite, solid percsuch mixtures may be econjunction with soap oFormulators using this pproviding data for the Eformulated products. Thformulate products for slabel if the formulator ocompiled with U.S. EPA the support of such use(

Aquatic Areas Formulation 

Intermediate 6836-209 

Not listed on the label. 

Not listed on the label. This product is a concen

only. This product shouwith any reducing or oxhypochlorite, solid percsuch mixtures may be econjunction with soap oFormulators using this pproviding data for the Eformulated products. Thformulate products for slabel if the formulator ocompiled with U.S. EPA the support of such use(