Difenoconazole Dietary Exposure Assessment DP#: 371613 

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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

WASHINGTON, D.C. 20460 

OFFICE OF 

PREVENTION, PESTICIDES 

AND TOXIC SUBSTANCES 

MEMORANDUM

Date: 21-Jan-2010 

Subject: Difenoconazole. Acute and Chronic Aggregate Dietary Exposure and Risk 

Assessments for the Section 3 Registration Request for Mango and Wax Apple. 

 

PC Code: 128847 DP Barcode: 371613 

Decision No.: 413927 Registration No.: None 

Petition Nos.: 9E7573 Regulatory Action: Section 3 

Assessment Type: Single Chemical, Dietary Registration Case No.: NA 

TXR No.: None CAS No.: 119446-68-3 

MRID No.: None 40 CFR: 180.475 

Reviewer: Thurston G. Morton, Chemist 

Risk Assessment Branch IV/Health Effects Division (RABIV/HED; 7509P) 

Through: Doug Dotson, PhD., Chemist 

Julie Van Alstine, MPH, Environmental Health Scientist 

Dietary Exposure Science Advisory Council (DESAC) 

 And 

Susan V. Hummel, Senior Chemist 

RABIV/HED (7509P) 

To: Yan Donovan, Risk Assessor 

RABIV/HED (7509P) 

 And 

Tony Kish 

Fungicide Branch/RD (7505P) 

Executive Summary
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Aggregate (food + water) acute and chronic dietary risk assessments were conducted using the 

Dietary Exposure Evaluation Model - Food Consumption Intake Database (DEEM-FCIDTM, ver. 

2.03). This model uses food consumption data from the United States Department of 

Agriculture’s (USDA’s) Continuing Surveys of Food Intakes by Individuals (CSFII; 1994-1996 

and 1998). The analyses were performed to support a Section 3 request for new uses of the 

fungicide difenoconazole [1-[2-[2-chloro-4-(4-chlorophenoxy)phenyl]-4-methyl-1,3-dioxolan-2-

ylmethyl]-1H-1,2,4-triazole] in/on mango and wax apple. 

The unrefined acute analysis assumed tolerance-level residues, 100% crop treated (CT), and the 

available empirical or DEEMTM (ver. 7.81) default processing factors. The resulting acute food 

exposure estimates were less than HED’s level of concern (<100% of the acute populationadjusted dose (aPAD)) at the 95th percentile of the exposure distribution for the general U.S. 

population (7 % aPAD) and all population sub-groups; the most highly exposed population 

subgroup was children1-2 years old with 16 % aPAD. The somewhat refined chronic analysis 

assumed tolerance-level residues for some commodities, average field trial residues for the 

majority of commodities, the available empirical or DEEMTM (ver. 7.81) default processing 

factors, and 100 % CT. The resulting chronic food exposure estimates were less than HED’s 

level of concern (<100% of the chronic population-adjusted dose (cPAD)) for the general U.S. 

population (17 % cPAD) and all population sub-groups; the most highly exposed population 

subgroup was children 1-2 years old with 45 % cPAD. 

The requested uses of difenoconazole did not result in an increase in dietary exposure 

estimates for free triazole or conjugated triazoles. Therefore, the last dietary exposure 

analyses for the triazole metabolites (M. Negussie, 28 Oct. 2009) have not changed. 

I. Introduction

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the PAD. The PAD is equivalent to the point of departure (POD, 

NOAEL, LOAEL, e.g.) divided by the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. HED is generally concerned when estimated cancer risk exceeds one 

in one million. References which discuss the acute and chronic risk assessments in more detail 

are available on the EPA/pesticides web site: “Available Information on Assessing Exposure 

from Pesticides, A User’s Guide,” 21-JUN-2000, web link: http://www.epa.gov/fedrgstr/EPAPEST/2000/July/Day-12/6061.pdf; or see SOP 99.6 (20-AUG-1999). 

The most recent dietary risk assessment for difenoconazole was conducted by T. Morton (22-

September-2009; DP#367383). 

II. Residue Information
Difenoconazole Dietary Exposure Assessment DP#: 371613 

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Difenoconazole tolerances are published in 40 CFR§180.475. 

Residues of Concern in Plants and Livestock: The HED Metabolism Assessment Review 

Committee (MARC) has determined that for tolerance expression and risk assessment purposes, 

the residue of concern is difenoconazole per se for plant and livestock commodities. The 

MARC, however, stated that if tolerances are proposed for difenoconazole resulting from foliar 

uses which result in higher residue levels of CGA-205375 than parent, then the need to include 

CGA-205375 should be reconsidered (Memo, G. Kramer, 22-JUL-1994; No DP#). Because the 

petitioner has now proposed foliar uses of difenoconazole, which result in higher residues in 

crop commodities, the need to include metabolite CGA 205375 in the tolerance expression 

and/or risk assessment has been re-examined. Based upon a review of the previously-submitted 

metabolism data for difenoconazole, HED concludes the residue of concern for both tolerance 

setting and risk assessment for the crops included in this petition is difenoconazole. However, 

HED concludes the residue of concern in livestock for tolerance setting and risk assessment are 

difenoconazole and its metabolite CGA 205375 (for more details, see the summary document, 

DP# 340379). Table 1 below summarizes tolerance expression and the residues of concern in 

plant and livestock commodities. 

Table 1. Difenoconazole Residues of Concern in Plants and Ruminants.

Matrix Residues of Concern

For Risk Assessment For Tolerance Expression

Plants Primary and Rotational crops Parent Only Parent Only

Livestock Ruminant and Poultry Parent and CGA 205375 Parent and CGA 205375

Drinking Water Parent Only NA

Recommended Tolerances: Based on the residue chemistry data submitted with the current 

petitions, HED recommended for establishment of the new food tolerances (DP# 366507, B. 

Cropp-Kohlligian, 21-Jan-2010). The recommended, established, and revised tolerances are 

listed in Table 2 below. 

Table 2. Tolerance Summary for Difenoconazole. 
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Commodity Existing/Established 

Tolerances (ppm) 

New Recommended Tolerances (ppm) 

Almond, nutmeat1 0.05 0.03 tree nut 

Almond, hulls1 5.0 7.0 

Brassica subgroup 5A none 1.9 

Brassica subgroup 5B none 35 

Citrus, dried pulp none 2.5 

Citrus oil none 25 

Fruit, citrus, group 10 none 0.6 

Grape 0.1 4.0 

Grape, raisin none 6.0 

Nut, tree, group 14 none 0.03 

Onion, bulb, subgroup 3—07A none 0.20 

Onion, green, subgroup 3—07B none 6.0 

Pistachios none 0.03 

Vegetable, cucurbit, group 91 1.0 individual RACs 0.7 

Fruit, Pome, group 11 1.0 ------ 

Vegetable, Fruiting, Group 8 0.60 ------ 

Vegetable, Tuberous and Corm, 

subgroup 1C 

0.01 ------ 

Beet, sugar2 0.30 ------ 

Papaya 0.30 ------ 

Apple, wet pomace 4.5 ------ 

Beet, sugar, dried pulp 1.9 ------ 

Potato, processed waste 0.04 ------ 

Banana 0.2 ------ 

Barley, grain 0.1 ------ 

Barley, hay 0.05 ------ 

Barley, straw 0.05 ------ 

Canola, seed 0.01 ------ 

Cattle fat 0.10 ------ 

Cattle, meat 0.05 ------ 

Cattle, meat byproducts 0.10 ------ 

Cattle, liver 0.20 ------ 

Corn, sweet, forage 0.01 ------ 

Corn, sweet, kernel plus cob 

with husks removed 

0.01 ------ 

Corn, sweet, stover 0.01 ------ 

Cotton, gin byproducts 0.05 ------ 

Cotton, undelinted seed 0.05 ------ 

Egg3 0.10 ------ 

Goat, fat 0.10 ------ 

Goat, meat 0.05 ------ 

Goat, meat byproducts (except 

liver) 

0.10 ------ 
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Table 2. Tolerance Summary for Difenoconazole. 

Commodity Existing/Established 

Tolerances (ppm) 

New Recommended Tolerances (ppm) 

Goat, liver 0.20 ------ 

Hog, fat 0.10 ------ 

Hog, meat 0.05 ------ 

Hog, meat byproducts (except 

liver) 

0.1 ------ 

Hog, liver 0.20 ------ 

Horse, fat 0.10 ------ 

Horse, meat 0.05 ------ 

Horse, meat byproducts (except 

liver) 

0.10 ------ 

Horse, liver 0.20 ------ 

Milk 0.01 ------ 

Rye, grain 0.1 ------ 

Sheep, fat 0.10 ------ 

Sheep, meat 0.05 ------ 

Sheep, meat byproducts (except 

liver) 

0.10 ------ 

Sheep, liver 0.20 ------ 

Wheat, forage 0.1 ------ 

Wheat, grain 0.1 ------ 

Wheat, straw 0.1 ------ 

Wax apple None 0.07 

Mango None 0.07 

1

 Section 18 emergency exemption tolerance. 

2

 The registered tolerance on sugar beet (0.01 ppm) needs to be changed to 0.3 ppm; see “Notes to RD” in memorandum: M. Sahafeyan, 

D351715, 07-MAY-08. 

3

 Based on a feeding study, HED recommended the tolerances for poultry commodities (except egg) be removed and the egg tolerance be 

increased to the current level of 0.1 ppm.

The requested uses of difenoconazole did not result in an increase in dietary exposure 

estimates for free triazole or conjugated triazoles. Therefore, the last dietary exposure 

analyses for the triazole metabolites (M. Negussie, 28 Oct. 2009) have not changed. 

Food Residues and processing factors used in the Acute and Chronic Analysis: The acute 

analysis assumed tolerance-level residues and 100% CT for all the registered and proposed 

crops. Tolerance-level residues were also assumed for all livestock tissues in this assessment. 

The chronic analysis assumed tolerance-level residues for some commodities, average field trial 

residues for the majority of commodities, and 100 % CT. Those commodities where field trial 

data were used are summarized below. HED SOP 2000.1 Guidance for Translation of Field 

Trial Data from Representative Commodities in the Crop Group Regulation to Other 

Commodities in Each Crop Group/Subgroup dated 9/12/2000 was used in translating to other 

commodities in the crop group. Experimental processing factors were used for apple juice 

(0.04x), grape juice (0.2x), citrus juices (0.1x), potato chips (0.5x), potato granules/flakes (0.5x), 

raisin (3.5x chronic only), sugar beet molasses (0.6x), tomato paste (1.6x), and tomato puree 
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(0.5x); DEEMTM (ver. 7.81) default processing factors were assumed for other processed 

commodities. 

No free triazole or conjugated triazole residue data were submitted with the mango residue 

field trial submission. However, current dietary exposure estimates are conservative 

enough that submission of this residue data on mango is not expected to result in an 

increase in aggregate exposure. 

Almond: Field trial residues were used from MRID 47586101. 

Apple: Field trial residues were used from MRID 46950233. 

Broccoli: Field trial residues were used from MRID 47586102. Residues from 1-7 day PHI were 

used since registered labels allow from 1-7 day PHIs. 

Cabbage: Field trial residues were used from 47586102. Residues from 1-7 day PHI were used 

since registered labels allow from 1-7 day PHIs. To refine the dietary exposure data from only 

cabbage samples without wrapper leaves were used. 

Cantaloupe: Field trial residues were used from MRID 47586103. Residues from 0-1 day PHI 

were used since registered labels allow from 0-1 day PHI. 

Cucumber: Field trial residues were used from MRID 47586103. Residues from 0-1 day PHI 

were used since registered labels allow from 0-1 day PHI. 

Grape: Field trial residues were used from MRID 47586105. 

Grapefruit: Field trial residues were used from MRID 47586104. 

Leaf Lettuce: Field trial residues were used from MRIDs 47417703 and 47417706. 

Lemon: Field trial residues were used from MRID 47586104. 

Lime: Field trial residues were used from MRID 47586104. 

Mustard Greens: Field trial residues were used from MRIDs 47417704, 47417707, and 

47586102. Residues from 1-7 day PHI were used since registered labels allow from 1-7 day 

PHIs. 

Orange: Field trial residues were used from MRID 47586104. 

Pear: Field trial residues were used from MRID 46950233. 

Pecan: Field trial residues were used from MRID 47586106. 

Peppers: Field trial residues were used from MRID 46950234. 
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Potato: Field trial residues were used from MRID 46950235. 

Sugar Beet: Field trial residues were used from MRID 46950236. 

Summer Squash: Field trial residues were used from MRID 47586103. Residues from 0-1 day 

PHI were used since registered labels allow from 0-1 day PHIs. 

Tomato: Field trial residues were used from MRIDs 46950234, 47417705, and 47417708. 

III. Drinking Water Data 

The drinking water estimates used in the dietary risk assessment were provided by the 

Environmental Fate and Effects Division (EFED; Memo, I. Maher, 28-MAY-2009; D361398). 

EFED conducted a Tier II drinking water assessment for surface water sources using the 

Pesticide Root Zone/Exposure Analysis Modeling System (PRZM/EXAMS) for the registered 

and proposed new uses. Among all the registered and proposed new uses, the highest estimated 

drinking water concentrations (EDWCs) for surface water sources were derived for aerial 

applications of difenoconazole to New York grapes at the maximum annual application rate of 

0.46 lb ai/acre. The estimated drinking water residues for 1-in-10 year annual peak, 1-in-10 year 

annual mean, and 36-year annual mean are 15.8, 10.4, and 7.62 μg/L (ppb) respectively. 

The highest SCI-GROW estimated drinking water concentration of difenoconazole from shallow 

ground water sources is 1.23 x 10-2 μg/L derived for the maximum proposed application rate to 

citrus fruit (0.50 lb ai/A), i.e. agricultural uses. Based on the previous drinking water 

assessment, this estimate is lower than an estimate for non-agricultural uses of 1.28 x 10-2 μg/L, 

obtained for the maximum application rate for ornamentals (0.52 lb ai/A; D333319). These 

concentrations can be considered as both the acute and chronic groundwater values. 

The 1-in-10 year annual peak EDWC of 15.8 μg/L (ppb) was used for the acute dietary exposure 

analysis and the 1-in-10 year annual mean EDWC of 10.4 μg/L (ppb) was used for the chronic 

dietary exposure analysis. 

IV. DEEM-FCIDTM Program and Consumption Information

Difenoconazole acute and chronic dietary exposure assessments were conducted using the 

DEEM-FCIDTM (ver. 2.03), which incorporates consumption data from USDA’s CSFII (1994-

1996 and 1998). The 1994-96, 98 data are based on the reported consumption of more than 

20,000 individuals over two non-consecutive survey days. Foods “as consumed” (e.g., apple 

pie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or 

N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe 

translation files developed jointly by USDA/ARS and EPA. For chronic exposure assessment, 

consumption data are averaged for the entire U.S. population and within population subgroups, 

but for acute exposure assessment are retained as individual consumption events. Based on 

analysis of the 1994-96, 98 CSFII consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 
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following population subgroups: the general U.S. population, all infants (<1 year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50+ years 

old. 

For chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form. The resulting residue consumption 

estimate for each food/food form is summed with the residue consumption estimates for all other 

food/food forms on the commodity residue list to arrive at the total average estimated exposure. 

Exposure is expressed in mg/kg body weight/day and as a percent of the cPAD. This procedure 

is performed for each population subgroup. 

For acute exposure assessments, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or “matched” in multiple random pairings with residue 

values and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aPAD on both a user (i.e., those who reported eating relevant 

commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for all tiers of analysis. However, for Tiers 1 and 2, significant 

differences in user vs. per capita exposure and risk are identified and noted in the risk 

assessment. 

V. Toxicological Information

On 08-SEP-1998, HED’s Hazard Identification Assessment Review Committee (HIARC) 

evaluated the toxicology database of difenoconazole and re-assessed the RfD established in 

1994, as well as the toxicological endpoints for the dietary and occupational exposure risk 

assessments that were selected in 1994. At this meeting, the HIARC also addressed the potential 

enhanced sensitivity of infants and children from exposure to difenoconazole as required by the 

Food Quality Protection Act (FQPA) of 1996 (HED Doc. No. 012873, 25-SEP-1998). In July, 

2007, the RAB1 toxicologists and risk assessment team met to reevaluate the endpoints selected 

by the HIARC since new studies were submitted. RAB1 toxicologists and risk assessment team 

also reevaluated FQPA assessments. The risk assessment team concluded that the default 10x 

FQPA Safety Factor (SF) should be reduced to 1x when assessing acute and chronic dietary 

exposures (M.Sahafeyan, D333320, 09-AUG-07). The relevant endpoints are shown in Table 3. 

For purposes of this action, HED recently reviewed HED’s 27-JUL-1994 Cancer Peer Review 

Committee (CPRC) report (Memo, Jess Rowland and Esther Rinde) on difenoconazole and the 

supporting data-evaluation records (DERs). HED concluded that difenoconazole is a very weak 

carcinogen, showing effects only at excessive doses. In retrospect, the CPRC should have 

classified this pesticide as a category C with no linear quantification of cancer risk. The cRfD, 

based on borderline liver effects in male rats at 24.1 mg/kg and a NOAEL of 0.96 mg/kg, is 

protective of any carcinogenic effects seen in the mouse (Memo, S. Levy et al., 05-AUG-2005; 
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DP# 319944). Therefore, a separate cancer dietary assessment is not being conducted for 

difenoconazole. 

Table 3. Summary of Toxicological Doses and Endpoints for Difenoconazole for Use in Dietary Risk 

Assessments. 

Exposure 

Scenario 

Point of 

Departure 

Uncertainty/FQPA 

Safety Factors 

RfD, PAD, for Risk 

Assessment 

Study and Relevant 

Toxicological Effects 

Acute Dietary 

(All 

populations) 

NOAEL = 

25 

mg/kg 

UFA = 10X 

UFH = 10X 

FQPA SF = 1X 

aRfD = aPAD = 0.25 

mg/kg/day 

Acute Neurotoxicity Study 

in Rats 

LOAEL= 200 mg/kg in 

males based on reduced 

fore-limb grip strength in 

males on day 1. 

Chronic 

Dietary (All 

populations) 

NOAEL = 

0.96 

mg/kg/day 

UFA = 10X 

UFH = 10X 

FQPA SF = 1X 

cRfD = cPAD = 

0.01mg/kg/day 

Combined chronic 

toxicity/carcinogenicity 

(rat; dietary) LOAEL = 

24.1/32.8 mg/kg/day (M/F) 

based on cumulative 

decreases in body-weight 

gains.

Cancer (oral, 

dermal, 

inhalation) 

Difenoconazole is classified as a Group C, possible human carcinogen with a non-linear (MOE) 

approach for human risk characterization (CPRC Document, 7/27/94, Memo, P. V. Shah dated 

March 3, 2007, HED Doc. No. 0054532). The chronic dietary exposure assessment is protective of 

cancer effects.

Point of Departure (POD) = A data point or an estimated point that is derived from observed dose-response data and 

 used to mark the beginning of extrapolation to determine risk associated with lower environmentally relevant human 

exposures. NOAEL = no observed adverse effect level. LOAEL = lowest observed adverse effect level. UF = 

uncertainty factor. UFA = extrapolation from animal to human (interspecies). UFH = potential variation in 

sensitivity among members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = 

population adjusted dose (a = acute, c = chronic). RfD = reference dose. 

VI. Results/Discussion

As stated above, for acute and chronic assessments, HED is concerned when dietary risk exceeds 

100% of the aPAD or cPAD, respectively. The following paragraphs are summaries of the 

DEEM-FCIDTM (ver. 2.03) acute and chronic exposure analyses. 

Acute and chronic aggregate (food + water) analyses were performed using DEEM-FCIDTM

estimating the dietary exposure of the U.S. population and various population subgroups. The 

results are summarized in Tables 4 and 5 below for acute and chronic analyses respectively. 

The resulting acute food exposure estimates were less than HED’s level of concern (<100% 

aPAD) at the 95th percentile of the exposure distribution for general US population (7 % aPAD) 

and all population sub-groups; the most highly exposed population subgroup was Children 1-2 

years old with 16 % aPAD. The resulting chronic food exposure estimates were less than HED’s 

level of concern (<100% cPAD) for the general U.S. population (17 % cPAD) and all population 

sub-groups; the most highly exposed population subgroup was children 1-2 years old with 45 % 

cPAD. A cancer dietary assessment was not conducted for difenoconazole because the cancer 

NOAEL is higher than the chronic RfD; therefore, the chronic dietary risk estimate is more 

protective. 
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Table 4. Summary of Acute Dietary Exposure and Risk for Difenoconazole at the 95th Percentile.

Population Subgroup aPAD (mg/kg/day) Exposure (mg/kg/day) %aPAD 

General U.S. Population 

0.25 

0.017747 7 

All Infants (< 1 year old) 0.0255139 10 

Children 1-2 years old 0.039565 16 

Children 3-5 years old 0.031818 13 

Children 6-12 years old 0.017949 7 

Youth 13-19 years old 0.008828 4 

Adults 20-49 years old 0.013083 5 

Adults 50+ years old 0.017255 7 

Females 13-49 years old 0.013281 5 

The bolded %aPAD is the highest. 

Table 5. Summary of Chronic Dietary Exposure and Risk for Difenoconazole.

Population Subgroup cPAD (mg/kg/day) Exposure (mg/kg/day) %cPAD 

General U.S. Population 

0.01 

0.001709 17 

All Infants (< 1 year old) 0.002445 25 

Children 1-2 years old 0.004484 45 

Children 3-5 years old 0.003624 36 

Children 6-12 years old 0.002061 21 

Youth 13-19 years old 0.001372 14 

Adults 20-49 years old 0.001376 14 

Adults 50+ years old 0.001548 16 

Females 13-49 years old 0.001402 14 

The bolded %cPAD is the highest. 

 

VII. Characterization of Inputs/Outputs

The acute analysis assumed tolerance-level residues, 100% CT, and empirical or DEEMTM

default processing factors. The chronic analysis assumed tolerance-level residues for some 

commodities, average field trial residues for the majority of commodities, 100 % CT, and 

empirical or DEEMTM default processing factors. Therefore, these analyses are considered 

conservative. They do not warrant the need for further refinement at this time. 
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VIII. Conclusions

An acute aggregate (food + water) dietary risk assessment was conducted for difenoconazole 

using the DEEM-FCIDTM (ver. 2.03) Model and assumed tolerance-level residues, 100% CT, and 

empirical or DEEMTM default processing factors. The chronic aggregate dietary risk assessment 

assumed tolerance-level residues for some commodities, average field trial residues for the 

majority of commodities, 100 % CT, and empirical or DEEMTM default processing factors. The 

resulting acute and chronic aggregate exposure estimates were less than HED’s level of concern. 

 For the general U.S. population, the aPAD and cPAD were 7 % and 17 %, respectively. The 

most highly-exposed population subgroups in the acute (at the 95th percentile of the exposure 

distribution) and chronic analyses were Children 1-2 years old (16 % aPAD) and children 1-2 

years old (45 % cPAD), respectively. 

IX. Attachments 

Attachment 1: DEEM-FCIDTM Acute Residue File 

Attachment 2: DEEM-FCIDTM Acute Exposure Estimates 

Attachment 3: DEEM-FCIDTM Chronic Residue File 

Attachment 4: DEEM-FCIDTM Chronic Exposure Estimates 

cc with all attachments: T. Morton (RABIV) 

RDI: D. Dotson and J.Van Alstine - DESAC (7-Jan-2010); S. Hummel (21-Jan-2010) 

Petition Number(s): PP#8F7482 

DP#: 371613 

PC Code: 128847 

T. Morton:S10922:PY1:(703)305-6691 
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Attachment 1: DEEM-FCIDTM Acute Residue File 

Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 

DifenocozoleNew Uses of Wax Apple and Mango\difenoconazole_acute-01-10.R98 

Chemical: Difenoconazole 

RfD(Chronic): .01 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day 

RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day 

Date created/last modified: 01-12-2010/10:30:55/8 Program ver. 2.03 

-------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ ------- 

95000230 O Banana 0.200000 1.000 1.000 

95000231 O Banana-babyfood 0.200000 1.000 1.000 

95000240 O Banana, dried 0.200000 3.900 1.000 

95000241 O Banana, dried-babyfood 0.200000 3.900 1.000 

95001280 O Cottonseed, oil 0.050000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.050000 1.000 1.000 

95001750 O Grape 4.000000 1.000 1.000 

95001760 O Grape, juice 4.000000 0.200 1.000 

95001761 O Grape, juice-babyfood 4.000000 0.200 1.000 

95001770 O Grape, leaves 4.000000 1.000 1.000 

95001780 O Grape, raisin 6.000000 1.000 1.000 

95001790 O Grape, wine and sherry 4.000000 1.000 1.000 

95002150 O Mango 0.070000 1.000 1.000 

95002151 O Mango-babyfood 0.070000 1.000 1.000 

95002160 O Mango, dried 0.070000 1.000 1.000 

95002170 O Mango, juice 0.070000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.070000 1.000 1.000 

95002450 O Papaya 0.300000 1.000 1.000 

95002451 O Papaya-babyfood 0.300000 1.000 1.000 

95002460 O Papaya, dried 0.300000 1.800 1.000 

95002470 O Papaya, juice 0.300000 1.500 1.000 

95002830 O Plantain 0.200000 1.000 1.000 

95002840 O Plantain, dried 0.200000 3.900 1.000 

86010000 O Water, direct, all sources 0.015800 1.000 1.000 

86020000 O Water, indirect, all sources 0.015800 1.000 1.000 

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 

21000460 M Beef, meat byproducts 0.100000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.100000 1.000 1.000 

21000470 M Beef, fat 0.100000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.100000 1.000 1.000 

21000480 M Beef, kidney 0.100000 1.000 1.000 

21000490 M Beef, liver 0.200000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.200000 1.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.100000 1.000 1.000 

23001710 M Goat, fat 0.100000 1.000 1.000 

23001720 M Goat, kidney 0.100000 1.000 1.000 

23001730 M Goat, liver 0.200000 1.000 1.000 

24001890 M Horse, meat 0.050000 1.000 1.000 

25002900 M Pork, meat 0.050000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 

25002910 M Pork, skin 0.100000 1.000 1.000 

25002920 M Pork, meat byproducts 0.100000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.100000 1.000 1.000 

25002930 M Pork, fat 0.100000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.100000 1.000 1.000 

25002940 M Pork, kidney 0.100000 1.000 1.000 

25002950 M Pork, liver 0.200000 1.000 1.000 

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.100000 1.000 1.000 

26003410 M Sheep, fat 0.100000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.100000 1.000 1.000 

26003420 M Sheep, kidney 0.100000 1.000 1.000 

26003430 M Sheep, liver 0.200000 1.000 1.000 

70001450 P Egg, whole 0.100000 1.000 1.000 

70001451 P Egg, whole-babyfood 0.100000 1.000 1.000 

70001460 P Egg, white 0.100000 1.000 1.000 

70001461 P Egg, white (solids)-babyfood 0.100000 1.000 1.000 

70001470 P Egg, yolk 0.100000 1.000 1.000 

70001471 P Egg, yolk-babyfood 0.100000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 371613 

PC Code: 128847

13 of 19 

27002220 D Milk, fat 0.010000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.010000 1.000 1.000 

27012230 D Milk, nonfat solids 0.010000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 

27022240 D Milk, water 0.010000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.010000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 

01010520 1A Beet, sugar 0.300000 1.000 1.000 

01010521 1A Beet, sugar-babyfood 0.300000 1.000 1.000 

01010530 1A Beet, sugar, molasses 0.300000 0.600 1.000 

01010531 1A Beet, sugar, molasses-babyfood 0.300000 0.600 1.000 

01032960 1C Potato, chips 0.010000 0.500 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.010000 0.500 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.010000 0.500 1.000 

01032980 1C Potato, flour 0.010000 0.500 1.000 

01032981 1C Potato, flour-babyfood 0.010000 0.500 1.000 

01032990 1C Potato, tuber, w/peel 0.010000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.010000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.010000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.010000 1.000 1.000 

03001640 3 Garlic 0.200000 1.000 1.000 

03001650 3 Garlic, dried 0.200000 1.000 1.000 

03001651 3 Garlic, dried-babyfood 0.200000 1.000 1.000 

03001980 3 Leek 6.000000 1.000 1.000 

03002370 3 Onion, dry bulb 0.200000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.200000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.200000 9.000 1.000 

03002390 3 Onion, green 6.000000 1.000 1.000 

03003380 3 Shallot 0.200000 1.000 1.000 

05010610 5A Broccoli 1.900000 1.000 1.000 

05010611 5A Broccoli-babyfood 1.900000 1.000 1.000 

05010620 5A Broccoli, Chinese 1.900000 1.000 1.000 

05020630 5B Broccoli raab 35.000000 1.000 1.000 

05010640 5A Brussels sprouts 1.900000 1.000 1.000 

05010690 5A Cabbage 1.900000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 35.000000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 1.900000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 1.900000 1.000 1.000 

05010830 5A Cauliflower 1.900000 1.000 1.000 

05021170 5B Collards 35.000000 1.000 1.000 

05021940 5B Kale 35.000000 1.000 1.000 

05011960 5A Kohlrabi 1.900000 1.000 1.000 

05022290 5B Mustard greens 35.000000 1.000 1.000 

05023180 5B Rape greens 35.000000 1.000 1.000 

05023890 5B Turnip, greens 35.000000 1.000 1.000 

08001480 8 Eggplant 0.600000 1.000 1.000 

08002340 8 Okra 0.600000 1.000 1.000 

08002700 8 Pepper, bell 0.600000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.600000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.600000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.600000 1.000 1.000 

08002720 8 Pepper, nonbell 0.600000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.600000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.600000 1.000 1.000 

08003740 8 Tomatillo 0.600000 1.000 1.000 

08003750 8 Tomato 0.600000 1.000 1.000 

08003751 8 Tomato-babyfood 0.600000 1.000 1.000 

08003760 8 Tomato, paste 0.600000 1.600 1.000 

08003761 8 Tomato, paste-babyfood 0.600000 1.600 1.000 

08003770 8 Tomato, puree 0.600000 0.500 1.000 

08003771 8 Tomato, puree-babyfood 0.600000 0.500 1.000 

08003780 8 Tomato, dried 0.600000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.600000 14.300 1.000 

08003790 8 Tomato, juice 0.600000 1.500 1.000 

09020210 9B Balsam pear 0.700000 1.000 1.000 

09010750 9A Cantaloupe 0.700000 1.000 1.000 

09010800 9A Casaba 0.700000 1.000 1.000 

09020880 9B Chayote, fruit 0.700000 1.000 1.000 

09021020 9B Chinese waxgourd 0.700000 1.000 1.000 

09021350 9B Cucumber 0.700000 1.000 1.000 

09011870 9A Honeydew melon 0.700000 1.000 1.000 

09023080 9B Pumpkin 0.700000 1.000 1.000 

09023090 9B Pumpkin, seed 0.700000 1.000 1.000 

09023560 9B Squash, summer 0.700000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.700000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 371613 

PC Code: 128847

14 of 19 

09023570 9B Squash, winter 0.700000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.700000 1.000 1.000 

09013990 9A Watermelon 0.700000 1.000 1.000 

09014000 9A Watermelon, juice 0.700000 1.000 1.000 

10001060 10 Citrus citron 0.600000 1.000 1.000 

10001070 10 Citrus hybrids 0.600000 1.000 1.000 

10001080 10 Citrus, oil 25.000000 1.000 1.000 

10001800 10 Grapefruit 0.600000 1.000 1.000 

10001810 10 Grapefruit, juice 0.600000 0.100 1.000 

10001970 10 Kumquat 0.600000 1.000 1.000 

10001990 10 Lemon 0.600000 1.000 1.000 

10002000 10 Lemon, juice 0.600000 0.100 1.000 

10002001 10 Lemon, juice-babyfood 0.600000 0.100 1.000 

10002010 10 Lemon, peel 0.600000 1.000 1.000 

10002060 10 Lime 0.600000 1.000 1.000 

10002070 10 Lime, juice 0.600000 0.100 1.000 

10002071 10 Lime, juice-babyfood 0.600000 0.100 1.000 

10002400 10 Orange 0.600000 1.000 1.000 

10002410 10 Orange, juice 0.600000 0.100 1.000 

10002411 10 Orange, juice-babyfood 0.600000 0.100 1.000 

10002420 10 Orange, peel 0.600000 1.000 1.000 

10003070 10 Pummelo 0.600000 1.000 1.000 

10003690 10 Tangerine 0.600000 1.000 1.000 

10003700 10 Tangerine, juice 0.600000 0.100 1.000 

11000070 11 Apple, fruit with peel 1.000000 1.000 1.000 

11000080 11 Apple, peeled fruit 1.000000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 1.000000 1.000 1.000 

11000090 11 Apple, dried 1.000000 8.000 1.000 

11000091 11 Apple, dried-babyfood 1.000000 8.000 1.000 

11000100 11 Apple, juice 1.000000 0.040 1.000 

11000101 11 Apple, juice-babyfood 1.000000 0.040 1.000 

11000110 11 Apple, sauce 1.000000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 1.000000 1.000 1.000 

11001290 11 Crabapple 1.000000 1.000 1.000 

11002100 11 Loquat 1.000000 1.000 1.000 

11002660 11 Pear 1.000000 1.000 1.000 

11002661 11 Pear-babyfood 1.000000 1.000 1.000 

11002670 11 Pear, dried 1.000000 6.250 1.000 

11002680 11 Pear, juice 1.000000 1.000 1.000 

11002681 11 Pear, juice-babyfood 1.000000 1.000 1.000 

11003100 11 Quince 1.000000 1.000 1.000 

14000030 14 Almond 0.030000 1.000 1.000 

14000031 14 Almond-babyfood 0.030000 1.000 1.000 

14000040 14 Almond, oil 0.030000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.030000 1.000 1.000 

14000590 14 Brazil nut 0.030000 1.000 1.000 

14000680 14 Butternut 0.030000 1.000 1.000 

14000810 14 Cashew 0.030000 1.000 1.000 

14000920 14 Chestnut 0.030000 1.000 1.000 

14001550 14 Filbert 0.030000 1.000 1.000 

14001560 14 Filbert, oil 0.030000 1.000 1.000 

14001850 14 Hickory nut 0.030000 1.000 1.000 

14002130 14 Macadamia nut 0.030000 1.000 1.000 

14002690 14 Pecan 0.030000 1.000 1.000 

14002820 14 Pistachio 0.030000 1.000 1.000 

14003910 14 Walnut 0.030000 1.000 1.000 

15000250 15 Barley, pearled barley 0.100000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 0.100000 1.000 1.000 

15000260 15 Barley, flour 0.100000 1.000 1.000 

15000261 15 Barley, flour-babyfood 0.100000 1.000 1.000 

15000270 15 Barley, bran 0.100000 1.000 1.000 

15001270 15 Corn, sweet 0.010000 1.000 1.000 

15001271 15 Corn, sweet-babyfood 0.010000 1.000 1.000 

15003280 15 Rye, grain 0.100000 1.000 1.000 

15003290 15 Rye, flour 0.100000 1.000 1.000 

15004010 15 Wheat, grain 0.100000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.100000 1.000 1.000 

15004020 15 Wheat, flour 0.100000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.100000 1.000 1.000 

15004030 15 Wheat, germ 0.100000 1.000 1.000 

15004040 15 Wheat, bran 0.100000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 371613 

PC Code: 128847

15 of 19 

Attachment 2: DEEM-FCIDTM Acute Exposure Estimates

U.S. Environmental Protection Agency Ver. 2.02 

DEEM-FCID ACUTE Analysis for DIFENOCONAZOLE (1994-98 data) 

Residue file: difenoconazole_acute-01-10.R98 Adjustment factor #2 used. 

Analysis Date: 01-12-2010/14:29:03 Residue file dated: 01-12-2010/14:23:34/8 

Daily totals for food and foodform consumption used. 

Run Comment: "" 

=============================================================================== 

Summary calculations (per capita): 

 95th Percentile 99th Percentile 99.9th Percentile 

 Exposure % aRfD Exposure % aRfD Exposure % aRfD 

 ---------- -------- ---------- -------- ---------- -------- 

U.S. Population: 

 0.017747 7.10 0.051415 20.57 0.142474 56.99 

All infants: 

 0.025139 10.06 0.040570 16.23 0.118410 47.36 

Children 1-2 yrs: 

 0.039565 15.83 0.087361 34.94 0.251716 100.69 

Children 3-5 yrs: 

 0.031818 12.73 0.070329 28.13 0.373423 149.37 

Children 6-12 yrs: 

 0.017949 7.18 0.038892 15.56 0.148702 59.48 

Youth 13-19 yrs: 

 0.008828 3.53 0.039549 15.82 0.137882 55.15 

Adults 20-49 yrs: 

 0.013083 5.23 0.041933 16.77 0.109522 43.81 

Adults 50+ yrs: 

 0.017255 6.90 0.062629 25.05 0.138639 55.46 

Females 13-49 yrs: 

 0.013281 5.31 0.042028 16.81 0.116292 46.52 
Difenoconazole Dietary Exposure Assessment DP#: 371613 

PC Code: 128847

16 of 19 

Attachment 3: DEEM-FCIDTM Chronic Residue File 

 Filename: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 

DifenocozoleNew Uses of Wax Apple and Mango\difenoconazole_chronic-01-10AverageFT.R98 

Chemical: Difenoconazole 

RfD(Chronic): .01 mg/kg bw/day NOEL(Chronic): 0 mg/kg bw/day 

RfD(Acute): .25 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day 

Date created/last modified: 01-12-2010/10:31:20/8 Program ver. 2.03 

-------------------------------------------------------------------------------- 

 EPA Crop Def Res Adj.Factors Comment 

 Code Grp Commodity Name (ppm) #1 #2 

-------- ---- ------------------------------- ---------- ------ ------ ------- 

95000230 O Banana 0.200000 1.000 1.000 

95000231 O Banana-babyfood 0.200000 1.000 1.000 

95000240 O Banana, dried 0.200000 3.900 1.000 

95000241 O Banana, dried-babyfood 0.200000 3.900 1.000 

95001280 O Cottonseed, oil 0.050000 1.000 1.000 

95001281 O Cottonseed, oil-babyfood 0.050000 1.000 1.000 

95001750 O Grape 0.613000 1.000 1.000 

95001760 O Grape, juice 0.613000 0.200 1.000 

95001761 O Grape, juice-babyfood 0.613000 0.200 1.000 

95001770 O Grape, leaves 0.613000 1.000 1.000 

95001780 O Grape, raisin 0.613000 3.500 1.000 

95001790 O Grape, wine and sherry 0.613000 1.000 1.000 

95002150 O Mango 0.070000 1.000 1.000 

95002151 O Mango-babyfood 0.070000 1.000 1.000 

95002160 O Mango, dried 0.070000 1.000 1.000 

95002170 O Mango, juice 0.070000 1.000 1.000 

95002171 O Mango, juice-babyfood 0.070000 1.000 1.000 

95002450 O Papaya 0.300000 1.000 1.000 

95002451 O Papaya-babyfood 0.300000 1.000 1.000 

95002460 O Papaya, dried 0.300000 1.800 1.000 

95002470 O Papaya, juice 0.300000 1.500 1.000 

95002830 O Plantain 0.200000 1.000 1.000 

95002840 O Plantain, dried 0.200000 3.900 1.000 

86010000 O Water, direct, all sources 0.010400 1.000 1.000 

86020000 O Water, indirect, all sources 0.010400 1.000 1.000 

21000440 M Beef, meat 0.050000 1.000 1.000 

21000441 M Beef, meat-babyfood 0.050000 1.000 1.000 

21000450 M Beef, meat, dried 0.050000 1.920 1.000 

21000460 M Beef, meat byproducts 0.100000 1.000 1.000 

21000461 M Beef, meat byproducts-babyfood 0.100000 1.000 1.000 

21000470 M Beef, fat 0.100000 1.000 1.000 

21000471 M Beef,fat-babyfood 0.100000 1.000 1.000 

21000480 M Beef, kidney 0.100000 1.000 1.000 

21000490 M Beef, liver 0.200000 1.000 1.000 

21000491 M Beef, liver-babyfood 0.200000 1.000 1.000 

23001690 M Goat, meat 0.050000 1.000 1.000 

23001700 M Goat, meat byproducts 0.100000 1.000 1.000 

23001710 M Goat, fat 0.100000 1.000 1.000 

23001720 M Goat, kidney 0.100000 1.000 1.000 

23001730 M Goat, liver 0.200000 1.000 1.000 

24001890 M Horse, meat 0.050000 1.000 1.000 

25002900 M Pork, meat 0.050000 1.000 1.000 

25002901 M Pork, meat-babyfood 0.050000 1.000 1.000 

25002910 M Pork, skin 0.100000 1.000 1.000 

25002920 M Pork, meat byproducts 0.100000 1.000 1.000 

25002921 M Pork, meat byproducts-babyfood 0.100000 1.000 1.000 

25002930 M Pork, fat 0.100000 1.000 1.000 

25002931 M Pork, fat-babyfood 0.100000 1.000 1.000 

25002940 M Pork, kidney 0.100000 1.000 1.000 

25002950 M Pork, liver 0.200000 1.000 1.000 

26003390 M Sheep, meat 0.050000 1.000 1.000 

26003391 M Sheep, meat-babyfood 0.050000 1.000 1.000 

26003400 M Sheep, meat byproducts 0.100000 1.000 1.000 

26003410 M Sheep, fat 0.100000 1.000 1.000 

26003411 M Sheep, fat-babyfood 0.100000 1.000 1.000 

26003420 M Sheep, kidney 0.100000 1.000 1.000 

26003430 M Sheep, liver 0.200000 1.000 1.000 

70001450 P Egg, whole 0.100000 1.000 1.000 

70001451 P Egg, whole-babyfood 0.100000 1.000 1.000 

70001460 P Egg, white 0.100000 1.000 1.000 

70001461 P Egg, white (solids)-babyfood 0.100000 1.000 1.000 

70001470 P Egg, yolk 0.100000 1.000 1.000 

70001471 P Egg, yolk-babyfood 0.100000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 371613 

PC Code: 128847

17 of 19 

27002220 D Milk, fat 0.010000 1.000 1.000 

27002221 D Milk, fat - baby food/infant for 0.010000 1.000 1.000 

27012230 D Milk, nonfat solids 0.010000 1.000 1.000 

27012231 D Milk, nonfat solids-baby food/in 0.010000 1.000 1.000 

27022240 D Milk, water 0.010000 1.000 1.000 

27022241 D Milk, water-babyfood/infant form 0.010000 1.000 1.000 

27032251 D Milk, sugar (lactose)-baby food/ 0.010000 1.000 1.000 

01010520 1A Beet, sugar 0.300000 1.000 1.000 

01010521 1A Beet, sugar-babyfood 0.300000 1.000 1.000 

01010530 1A Beet, sugar, molasses 0.300000 0.600 1.000 

01010531 1A Beet, sugar, molasses-babyfood 0.300000 0.600 1.000 

01032960 1C Potato, chips 0.005000 0.500 1.000 

01032970 1C Potato, dry (granules/ flakes) 0.005000 0.500 1.000 

01032971 1C Potato, dry (granules/ flakes)-b 0.005000 0.500 1.000 

01032980 1C Potato, flour 0.005000 0.500 1.000 

01032981 1C Potato, flour-babyfood 0.005000 0.500 1.000 

01032990 1C Potato, tuber, w/peel 0.005000 1.000 1.000 

01032991 1C Potato, tuber, w/peel-babyfood 0.005000 1.000 1.000 

01033000 1C Potato, tuber, w/o peel 0.005000 1.000 1.000 

01033001 1C Potato, tuber, w/o peel-babyfood 0.005000 1.000 1.000 

03001640 3 Garlic 0.200000 1.000 1.000 

03001650 3 Garlic, dried 0.200000 1.000 1.000 

03001651 3 Garlic, dried-babyfood 0.200000 1.000 1.000 

03001980 3 Leek 6.000000 1.000 1.000 

03002370 3 Onion, dry bulb 0.200000 1.000 1.000 

03002371 3 Onion, dry bulb-babyfood 0.200000 1.000 1.000 

03002380 3 Onion, dry bulb, dried 0.200000 9.000 1.000 

03002381 3 Onion, dry bulb, dried-babyfood 0.200000 9.000 1.000 

03002390 3 Onion, green 6.000000 1.000 1.000 

03003380 3 Shallot 0.200000 1.000 1.000 

05010610 5A Broccoli 0.221000 1.000 1.000 

05010611 5A Broccoli-babyfood 0.221000 1.000 1.000 

05010620 5A Broccoli, Chinese 0.221000 1.000 1.000 

05020630 5B Broccoli raab 5.100000 1.000 1.000 

05010640 5A Brussels sprouts 29.000000 1.000 1.000 

05010690 5A Cabbage 0.029000 1.000 1.000 

05020700 5B Cabbage, Chinese, bok choy 5.100000 1.000 1.000 

05010710 5A Cabbage, Chinese, napa 0.029000 1.000 1.000 

05010720 5A Cabbage, Chinese, mustard 0.221000 1.000 1.000 

05010830 5A Cauliflower 0.221000 1.000 1.000 

05021170 5B Collards 5.100000 1.000 1.000 

05021940 5B Kale 5.100000 1.000 1.000 

05011960 5A Kohlrabi 0.029000 1.000 1.000 

05022290 5B Mustard greens 5.100000 1.000 1.000 

05023180 5B Rape greens 5.100000 1.000 1.000 

05023890 5B Turnip, greens 5.100000 1.000 1.000 

08001480 8 Eggplant 0.133000 1.000 1.000 

08002340 8 Okra 0.600000 1.000 1.000 

08002700 8 Pepper, bell 0.133000 1.000 1.000 

08002701 8 Pepper, bell-babyfood 0.133000 1.000 1.000 

08002710 8 Pepper, bell, dried 0.133000 1.000 1.000 

08002711 8 Pepper, bell, dried-babyfood 0.133000 1.000 1.000 

08002720 8 Pepper, nonbell 0.133000 1.000 1.000 

08002721 8 Pepper, nonbell-babyfood 0.133000 1.000 1.000 

08002730 8 Pepper, nonbell, dried 0.133000 1.000 1.000 

08003740 8 Tomatillo 0.165000 1.000 1.000 

08003750 8 Tomato 0.165000 1.000 1.000 

08003751 8 Tomato-babyfood 0.165000 1.000 1.000 

08003760 8 Tomato, paste 0.165000 1.600 1.000 

08003761 8 Tomato, paste-babyfood 0.165000 1.600 1.000 

08003770 8 Tomato, puree 0.165000 0.500 1.000 

08003771 8 Tomato, puree-babyfood 0.165000 0.500 1.000 

08003780 8 Tomato, dried 0.165000 14.300 1.000 

08003781 8 Tomato, dried-babyfood 0.165000 14.300 1.000 

08003790 8 Tomato, juice 0.165000 1.500 1.000 

09020210 9B Balsam pear 0.055000 1.000 1.000 

09010750 9A Cantaloupe 0.137000 1.000 1.000 

09010800 9A Casaba 0.137000 1.000 1.000 

09020880 9B Chayote, fruit 0.310000 1.000 1.000 

09021020 9B Chinese waxgourd 0.055000 1.000 1.000 

09021350 9B Cucumber 0.055000 1.000 1.000 

09011870 9A Honeydew melon 0.137000 1.000 1.000 

09023080 9B Pumpkin 0.031000 1.000 1.000 

09023090 9B Pumpkin, seed 0.031000 1.000 1.000 

09023560 9B Squash, summer 0.031000 1.000 1.000 

09023561 9B Squash, summer-babyfood 0.031000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 371613 

PC Code: 128847

18 of 19 

09023570 9B Squash, winter 0.031000 1.000 1.000 

09023571 9B Squash, winter-babyfood 0.031000 1.000 1.000 

09013990 9A Watermelon 0.137000 1.000 1.000 

09014000 9A Watermelon, juice 0.137000 1.000 1.000 

10001060 10 Citrus citron 0.208000 1.000 1.000 

10001070 10 Citrus hybrids 0.208000 1.000 1.000 

10001080 10 Citrus, oil 25.000000 1.000 1.000 

10001800 10 Grapefruit 0.120000 1.000 1.000 

10001810 10 Grapefruit, juice 0.120000 0.100 1.000 

10001970 10 Kumquat 0.208000 1.000 1.000 

10001990 10 Lemon 0.176000 1.000 1.000 

10002000 10 Lemon, juice 0.176000 0.100 1.000 

10002001 10 Lemon, juice-babyfood 0.176000 0.100 1.000 

10002010 10 Lemon, peel 0.176000 1.000 1.000 

10002060 10 Lime 0.176000 1.000 1.000 

10002070 10 Lime, juice 0.176000 0.100 1.000 

10002071 10 Lime, juice-babyfood 0.176000 0.100 1.000 

10002400 10 Orange 0.208000 1.000 1.000 

10002410 10 Orange, juice 0.208000 0.100 1.000 

10002411 10 Orange, juice-babyfood 0.208000 0.100 1.000 

10002420 10 Orange, peel 0.208000 1.000 1.000 

10003070 10 Pummelo 0.120000 1.000 1.000 

10003690 10 Tangerine 0.208000 1.000 1.000 

10003700 10 Tangerine, juice 0.208000 0.100 1.000 

11000070 11 Apple, fruit with peel 0.203000 1.000 1.000 

11000080 11 Apple, peeled fruit 0.203000 1.000 1.000 

11000081 11 Apple, peeled fruit-babyfood 0.203000 1.000 1.000 

11000090 11 Apple, dried 0.203000 8.000 1.000 

11000091 11 Apple, dried-babyfood 0.203000 8.000 1.000 

11000100 11 Apple, juice 0.203000 0.040 1.000 

11000101 11 Apple, juice-babyfood 0.203000 0.040 1.000 

11000110 11 Apple, sauce 0.203000 1.000 1.000 

11000111 11 Apple, sauce-babyfood 0.203000 1.000 1.000 

11001290 11 Crabapple 0.203000 1.000 1.000 

11002100 11 Loquat 0.123000 1.000 1.000 

11002660 11 Pear 0.123000 1.000 1.000 

11002661 11 Pear-babyfood 0.123000 1.000 1.000 

11002670 11 Pear, dried 0.123000 6.250 1.000 

11002680 11 Pear, juice 0.123000 1.000 1.000 

11002681 11 Pear, juice-babyfood 0.123000 1.000 1.000 

11003100 11 Quince 0.123000 1.000 1.000 

14000030 14 Almond 0.005000 1.000 1.000 

14000031 14 Almond-babyfood 0.005000 1.000 1.000 

14000040 14 Almond, oil 0.005000 1.000 1.000 

14000041 14 Almond, oil-babyfood 0.005000 1.000 1.000 

14000590 14 Brazil nut 0.007000 1.000 1.000 

14000680 14 Butternut 0.007000 1.000 1.000 

14000810 14 Cashew 0.007000 1.000 1.000 

14000920 14 Chestnut 0.005000 1.000 1.000 

14001550 14 Filbert 0.007000 1.000 1.000 

14001560 14 Filbert, oil 0.007000 1.000 1.000 

14001850 14 Hickory nut 0.007000 1.000 1.000 

14002130 14 Macadamia nut 0.007000 1.000 1.000 

14002690 14 Pecan 0.007000 1.000 1.000 

14002820 14 Pistachio 0.005000 1.000 1.000 

14003910 14 Walnut 0.007000 1.000 1.000 

15000250 15 Barley, pearled barley 0.100000 1.000 1.000 

15000251 15 Barley, pearled barley-babyfood 0.100000 1.000 1.000 

15000260 15 Barley, flour 0.100000 1.000 1.000 

15000261 15 Barley, flour-babyfood 0.100000 1.000 1.000 

15000270 15 Barley, bran 0.100000 1.000 1.000 

15001270 15 Corn, sweet 0.010000 1.000 1.000 

15001271 15 Corn, sweet-babyfood 0.010000 1.000 1.000 

15003280 15 Rye, grain 0.100000 1.000 1.000 

15003290 15 Rye, flour 0.100000 1.000 1.000 

15004010 15 Wheat, grain 0.100000 1.000 1.000 

15004011 15 Wheat, grain-babyfood 0.100000 1.000 1.000 

15004020 15 Wheat, flour 0.100000 1.000 1.000 

15004021 15 Wheat, flour-babyfood 0.100000 1.000 1.000 

15004030 15 Wheat, germ 0.100000 1.000 1.000 

15004040 15 Wheat, bran 0.100000 1.000 1.000 
Difenoconazole Dietary Exposure Assessment DP#: 371613 

PC Code: 128847

19 of 19 

Attachment 4: DEEM-FCIDTM Chronic Exposure Estimates

U.S. Environmental Protection Agency Ver. 2.00 

DEEM-FCID Chronic analysis for DIFENOCONAZOLE (1994-98 data) 

Residue file name: C:\Documents and Settings\tmorton\My Documents\MyFiles\DEEM Files\128847 

DifenocozoleNew Uses of Wax Apple and Mango\difenoconazole_chronic-01-10AverageFT.R98 

 Adjustment factor #2 used. 

Analysis Date 01-12-2010/14:26:21 Residue file dated: 01-12-2010/14:24:16/8 

Reference dose (RfD, Chronic) = .01 mg/kg bw/day 

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 Total exposure by population subgroup 

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 Total Exposure 

 ----------------------------------- 

 Population mg/kg Percent of 

 Subgroup body wt/day Rfd 

-------------------------------------- ------------- --------------- 

U.S. Population (total) 0.001709 17.1% 

U.S. Population (spring season) 0.001689 16.9% 

U.S. Population (summer season) 0.001761 17.6% 

U.S. Population (autumn season) 0.001678 16.8% 

U.S. Population (winter season) 0.001710 17.1% 

Northeast region 0.001653 16.5% 

Midwest region 0.001671 16.7% 

Southern region 0.001610 16.1% 

Western region 0.001958 19.6% 

Hispanics 0.001635 16.3% 

Non-hispanic whites 0.001626 16.3% 

Non-hispanic blacks 0.002000 20.0% 

Non-hisp/non-white/non-black 0.002426 24.3% 

All infants (< 1 year) 0.002445 24.5% 

Nursing infants 0.001287 12.9% 

Non-nursing infants 0.002885 28.9% 

Children 1-6 yrs 0.003762 37.6% 

Children 7-12 yrs 0.001941 19.4% 

Females 13-19 (not preg or nursing) 0.001233 12.3% 

Females 20+ (not preg or nursing) 0.001490 14.9% 

Females 13-50 yrs 0.001475 14.7% 

Females 13+ (preg/not nursing) 0.001295 13.0% 

Females 13+ (nursing) 0.001522 15.2% 

Males 13-19 yrs 0.001506 15.1% 

Males 20+ yrs 0.001385 13.9% 

Seniors 55+ 0.001574 15.7% 

Children 1-2 yrs 0.004484 44.8% 

Children 3-5 yrs 0.003624 36.2% 

Children 6-12 yrs 0.002061 20.6% 

Youth 13-19 yrs 0.001372 13.7% 

Adults 20-49 yrs 0.001376 13.8% 

Adults 50+ yrs 0.001548 15.5% 

Females 13-49 yrs 0.001402 14.0% 

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