### SAT Report PMN Number: P-12-0404 SAT Date: Print Date: 4/1/2014

Related cases :

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 2 2

Persistence Bioaccum Toxicity Comments 3 12

Exposure Based Review : Health: N o Ecotox: N o
Routes of exposure : Health: Dermal Drinking Water Inhalation Ecotox: All releases to water Fate: ; Keywords : Keywords: DEVEL, THYMUS, LIVER, LUNG, IRR, AQUATOX-A,C
Summary of Assessment :

Fate : Fate Summary: P-12-0404 FATE:

log Koc = 2.23 (E) log Fish BCF = 1.39 (E) log Fish BAF = 1.57 (E)POTW removal (%) = 90 via unknown biodeg; All Analogs: Substance C: OPPTS835.3200/835.3210: Inherently Biodegradable; Substance B: OECD301B(Mod Sturm CO2 ev): 6-11%/28d NRB. Time for complete ultimate aerobic biodeg > mo Sorption to soils/sediments = low PBT Potential: P3B1 *CEB FATE: Migration to ground water = rapid

Health : Health Summary: Absorption is nil through the skin as the neat material, moderate through the skin when in solution, and good through the lungs and GI tract based on p hysical/chemical properties. There is concern for lung effects if inhaled and irritation based on the properties of the PMN material. There is concern for liver and thymus effects and developmental toxicity based on the submitted study for an analog with a paternal NOEL = 10 mg/kg and a developmental NOEL = 50 mg /kg. Moderate concern. Test Data: Substance B

negative in Salmonella and E coli with and without activation oral absorption /metabolism study in rats - serum half-life is approximately 6 hours (males only) corrosive to the rabbit eye mild skin irritant in rabbits not a dermal sensitizer in guinea pigs, Magnusson and Kligman acute oral study in rats - 2 of 6 died at 2000 mg/kg, lethargy, ventro-lateral recumbency, hunched p osture, uncoordinated movements, flat gait, shallow respiration, p iloerection, salivation

negative for induction of chromosome aberrations in cultured human lymphocytes with and without activation oral combined repeated dose toxicity study with reproduction/developmental screening toxicity test in rats (10, 50, 250 mg/kg) - salivation, p erioral substance and urine-stained abdominal fur at 250 mg/kg; reduced body weight gain and feed consumption at 50 and 250 mg/kg, microscopic changes in liver at 50 and 250 mg/kg; microscopic changes in thymus at 250 mg/kg; no effects on FOB and motor activity; no reproductive effects; reduced number of liveborn pups and increase in stillborn pups at 250 mg/kg; reduced viability of pups and reduced pup weights at 250 mg/kg; p aternal NOEL = 10 mg/kg; developmental NOEL = 50 mg/kg oral absorption/metabolism study in rats (males and females only) - analytic phase of study not completed due to problems with the animals no skin irritation in rabbits oral absorption/metabolism study in rats (male and female) - halflife in serum = 17 hours slight eye irritant in rabbits not a dermal sensitizer in guinea pigs, Magnusson and Kligman acute oral study in rats - no deaths at 2000 mg/kg, lethargy, uncoordinated movements, hunched p osture, chromodacryorrhea28-day oral study in rats (15, 30 mg/kg) - hunched posture, slight increase in severity of haemopoiesis of the spleen, haemolytic serum samples at 30 mg/kg

Ecotox :
Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 28 daphnid 48-h LC50 34 green algal 96-h EC50 2.3 fish

_ chronic value 0.21 daphnid

_ chronic value 4.4

algal

_ chronic value 0.48
Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for amides; SAR chemical class = amide; MW 343; p H7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and TOC <2.0 mg/L;

Factors Values Comments Assessment Factor 10 Concentration of Concern ( p pb) 21

SARs amides SAR Class amide Ecotox Category N one
Ecotox Factors Comments:

SAT Chair: Becky Jones