### SAT Report PMN Number: P-15-0098 SAT Date: 12/23/2014 Print Date: 2/27/2015

Related cases : Yes Health related cases: Ecotox related cases: 8.

Concern levels : Type of Concern: Health Eco Comments Level of Concern: 1-2 2

Persistence Bioaccum Toxicity Comments 2 11

Exposure Based Review : Health: N o Ecotox: Yes Exposure based testing (eco): Acute Aquatic Base Set Testing

Routes of exposure : Health: Dermal Inhalation Ecotox: All releases to water Fate: ;

P 2 Rec Comments : Comment: P2REC: SAT: Forward

Keywords : Keywords: N EURO; AQUATOX; GLOBAL WARMING; OZONE DEPLETION
Summary of Assessment :

Fate : Fate Summary: P-15-0098 FATE: Estimations for typical Liquid with MP < 25 C (E) log Kow = 2.98 (E) S = 37.7 mg/L at 25 C (E) VP = 27.8 torr at 25 C (E)BP = 107 C (E) H = 2.25E-2 (E) log Koc = 2.38 (E) log Fish BCF = 1.63 (E) log Fish BAF = 1.92 (E) POTW removal (%) = 90 via stripping and sorption Time for complete ultimate aerobic biodeg ≥ mo Sorption to soils/sediments = moderate Volatilization half-life from a standard river = 1 hrs Volatilization half-life from a standard lake = 5 da Atmospheric Oxidation Half-life = 360 hr via OH radical PBT Potential: P2B1 *CEB FATE: Migration to ground water = moderate

Health : Health Summary: Absorption is good all routes (analog). Concern for anesthesia at inhalation high doses. Test Data: : (-) in yeast, Salmonella, and E. Coli with and without activation

(-) Salmonella with and without activation; (-) E. coli with and without activation; nonclastogenic in a human lymphocyte assay with and without activation; (-) inhalation mouse micronucleus assay; rat inhalation LC0 = 360,000 p p m , rats were anesthetized at this dose; rat 31-day inhalation NOEL = 10,000 p p m , anesthetic effects during the exposure period at 50,000 p p m ; rat 13-week inhalation NOEC = 5000 p p m (M) or 15,000 p p m (F) with anesthetic effects at 15,000 p p m (M) or 50,000 p p m (F); rat 2-year inhalation NOAEL = 50,000 p p m ; evaluation of the same 2-year inhalation study showed no carcinogenic effects at doses up to 50,000 p p m ; mouse 13-week inhalation NOEL = 15,000 p p m with anesthetic effects at 50,000 p p m ; rat inhalation developmental range finding NOEL = 50,000 p p m ; rat inhalation developmental NOEL = 15,000 p p m (dams, reduced feed consumption and reduced body weight gain) and 50,000 p p m (developmental); rabbit inhalation developmental range finding NOEL = 50,000 p p m ; rabbit inhalation developmental NOEL = 15,000 p p m (dams, feed consumption), 50,000 p p m (developmental); closed chamber gas uptake exposure of rats, mice, and hamsters, were determined and was identified as the major

Ecotox :
Test Organism Test Type Test End Point Predicted Measured Comments

fish 96-h LC50 11.4-34.7 daphnid 48-h LC50 7.3-20.9 green algal 96-h EC50 8.9-20.1 fish

_ chronic value 1.3-3.6 daphnid

_ chronic 0.99-2.4value algal

_ chronic value 3.0-6.0

Sewage Sludge 3-h EC50

_ Sewage Sludge

_ Chronic Value _

Ecotox Values Comments: Predictions are based on SARs for SAR chemical class = solid with unknown mp(P); log Kow = 1.6 (P, ; S = >1000 mg/L at 20 C (P, PMN); p H7; effective concentrations based on 100% active ingredients and mean measured concentrations; hardness <150.0 mg/L as CaCO3; and <2.0 mg/L;

Factors Values Comments

Assessment Factor 10 Concentration of Concern ( p pb) 99

SARs SAR Class Ecotox Category

Ecotox Factors Comments:

SAT Chair: L Keifer 564-8916