Draft for Comment Version – March 1, 2014

Appendix B: Inhalation Equivalent 

Concentration Calculations for the 

Registration Review Chemical Analysis

Office of Pesticide Programs

Office of Chemical Safety and Pollution Prevention

U.S. Environmental Protection Agency

Washington, DC

March 1, 2014
Draft for Comment Version – March 1, 2014

2

Appendix Table B1: Inhalation Equivalent Concentration Calculations

Chemical Species: Strain

NOAEL 

(mg/kg/day) A CF D (hours) AF

IEC 

(mg/L)

IEC 

(ug/m3)

2,4-DB Rat: SD 31 1 43.5 6 1 0.1188 118774

Abamectin Rat: SD 0.12 1 43.5 6 1 0.0005 460

Acequinocyl Rabbit 60 1 22.8 6 1 0.4386 438596

Acequinocyl Rabbit 60 1 22.8 6 1 0.4386 438596

Acetochlor Rat: SD 150 1 43.5 6 1 0.5747 574713

Acibenzolar Rat: SD 8.2 1 43.5 6 1 0.0314 31418

Alachlor Rat: SD 150 1 43.5 6 1 0.5747 574713

Aliette Rat: SD 300 1 43.5 6 1 1.1494 1149425

Ametryn Rabbit 10 1 22.8 6 1 0.0731 73099

Amicarbazone Dog 6.28 1 32.6 6 1 0.0321 32106

Atrazine Rat: Wistar 6.25 1 45.2 6 1 0.0230 23046

Azoxystrobin Rat: Wistar 25 1 45.2 6 1 0.0922 92183

Benfluralin Rabbit 100 1 22.8 6 1 0.7310 730994

Bensulfuron-Methyl Dog 19.9 1 32.6 6 1 0.1017 101738

Bensulide Rat: SD 5.5 1 43.5 6 1 0.0211 21073

Bentazon Rat: Wistar 100 1 45.2 6 1 0.3687 368732

Bifenthrin Rat: Long Evans 3 1 44.2 6 1 0.0113 11312

Bispyribac-sodium Rabbit 100 1 22.8 6 1 0.7310 730994

Boscalid Dog 21.8 1 32.6 6 1 0.1115 111452

Bromacil Rat: SD 20 1 43.5 6 1 0.0766 76628

Bromoxynil Rat: SD 4 1 43.5 6 1 0.0153 15326

Buprofezin Rat: SD 13 1 43.5 6 1 0.0498 49808

Butylate Rat: SD 40 1 43.5 6 1 0.1533 153257

Carfentrazone-ethyl Rat: SD 50 1 43.5 6 1 0.1916 191571

Chlorfenapyr Dog 3.9 1 32.6 6 1 0.0199 19939

Chlorpropham Dog 5 1 32.6 6 1 0.0256 25562

Chlorsulfuron Rabbit 75 1 22.8 6 1 0.5482 548246

Clethodim Rat: SD 100 1 43.5 6 1 0.3831 383142

Clodinafop-propargyl Rat: SD 5 1 43.5 6 1 0.0192 19157

Clofencet Dog 5 1 32.6 6 1 0.0256 25562

Clofentezine Rat: SD 2 1 43.5 6 1 0.0077 7663

clomazone Rat: SD 100 1 43.5 6 1 0.3831 383142

Clopyralid Rat: Fischer 344 75 1 47 6 1 0.2660 265957

Clothianidin Rat: SD 9.8 1 43.5 6 1 0.0375 37548

Cyazofamid Rat: SD 100 1 43.5 6 1 0.3831 383142

Cyclanilide Rat: SD 4 1 43.5 6 1 0.0153 15326

Cyflumetofen Rat: Fischer 344 16.5 1 47 6 1 0.0585 58511

Cyhalofop-butyl Mouse 4.3 1 69.5 6 1 0.0103 10312
Draft for Comment Version – March 1, 2014

3

Appendix Table B1: Inhalation Equivalent Concentration Calculations

Chemical Species: Strain

NOAEL 

(mg/kg/day) A CF D (hours) AF

IEC 

(mg/L)

IEC 

(ug/m3)

Cyproconazole Rabbit 2 1 22.8 6 1 0.0146 14620

Cyprodinil Rat: SD 62 1 43.5 6 1 0.2375 237548

Daminozide Rat: SD 0.8 1 43.5 6 1 0.0031 3065

DCNA Dog 2.5 1 32.6 6 1 0.0128 12781

Deltamethrin Rat: Long Evans 1 1 44.2 6 1 0.0038 3771

Desmedipham Rat: Wistar 10 1 45.2 6 1 0.0369 36873

Dicamba Rat: SD 45 1 43.5 6 1 0.1724 172414

Difenoconazole Rat: SD 1.25 1 43.5 6 1 0.0048 4789

Dimethenamid Rat: SD 25 1 43.5 6 1 0.0958 95785

Dimethomorph Rat: SD 60 1 43.5 6 1 0.2299 229885

Diuron Rat: SD 58.7 1 43.5 6 1 0.2249 224904

Dodine Rat: SD 10 1 43.5 6 1 0.0383 38314

Emmamectin benoazate Mouse 0.75 1 69.5 6 1 0.0018 1799

Endothall Rat: SD 9.4 1 43.5 6 1 0.0360 36015

Ethalfluralin Rat: Fischer 344 12.5 1 47 6 1 0.0443 44326

Ethofumesate Rabbit 30 1 22.8 6 1 0.2193 219298

Ethoprop Rat: Wistar 0.14 1 45.2 6 1 0.0005 516

Etoxazole Dog 4.62 1 32.6 6 1 0.0236 23620

Fenamidone Rat: SD 10.4 1 43.5 6 1 0.0398 39847

Fenarimol Rat: Wistar 35 1 45.2 6 1 0.1291 129056

Fenazaquin Rat: SD 10 1 43.5 6 1 0.0383 38314

Fenbuconazole Rat: SD 5.1 1 43.5 6 1 0.0195 19540

Fenbutatin-oxide (Vendex) Rat: SD 5.1 1 43.5 6 1 0.0195 19540

Fenpropathrin Rat: Long Evans 5 1 44.2 6 1 0.0189 18854

Ferbam Rat: Wistar 1.5 1 45.2 6 1 0.0055 5531

Flazasulfuron Dog 2 1 32.6 6 1 0.0102 10225

Flonicamid Rat: Wistar 12 1 45.2 6 1 0.0442 44248

Florasulam Dog 5 1 32.6 6 1 0.0256 25562

Florasulam Dog 5 1 32.6 6 1 0.0256 25562

Flubendiamide Dog 2.6 1 32.6 6 1 0.0133 13292

Fludioxonil Rabbit 10 1 22.8 6 1 0.0731 73099

Flufenacet Rat: SD 1.7 1 43.5 6 1 0.0065 6513

Flumetralin Dog 11.6 1 32.6 6 1 0.0593 59305

Flumetsulam Dog 100 1 32.6 6 1 0.5112 511247

Flumeturon Rat: SD 10 1 43.5 6 1 0.0383 38314

Flumiclorac-pentyl Dog 100 1 32.6 6 1 0.5112 511247

Flumioxazan Rat: SD 3 1 43.5 6 1 0.0115 11494

Fluometuron Rat: SD 10 1 43.5 6 1 0.0383 38314

Fluopicolide Rabbit 20 1 22.8 6 1 0.1462 146199
Draft for Comment Version – March 1, 2014

4

Appendix Table B1: Inhalation Equivalent Concentration Calculations

Chemical Species: Strain

NOAEL 

(mg/kg/day) A CF D (hours) AF

IEC 

(mg/L)

IEC 

(ug/m3)

Fluoxastrobin Dog 3 1 32.6 6 1 0.0153 15337

Fluroxypyr Rat: SD 100 1 43.5 6 1 0.3831 383142

Fluthiacet-methyl Mouse 1.3 1 69.5 6 1 0.0031 3118

Flutriafol Rabbit 7.5 1 22.8 6 1 0.0548 54825

Folpet Rabbit 10 1 22.7 6 1 0.0734 73421

Fomesafen Rat: Wistar 0.5 1 45.2 6 1 0.0018 1844

Formetanate Rat: Long Evans 0.032 1 44.2 6 1 0.0001 121

Halosulfuron-Methyl Rabbit 50 1 22.8 6 1 0.3655 365497

Hexazinone Rabbit 50 1 22.8 6 1 0.3655 365497

Hexythiazox Rat: Fischer 344 30 1 47 6 1 0.1064 106383

Imazamethabenz Dog 25 1 32.6 6 1 0.1278 127812

Imazapic Rabbit 350 1 22.8 6 1 2.5585 2558480

Imazapic Rabbit 350 1 22.8 6 1 2.5585 2558480

Imazapyr Dog 250 1 32.6 6 1 1.2781 1278119

Imazaquin Dog 25 1 32.6 6 1 0.1278 127812

Imazethapyr Rabbit 300 1 22.8 6 1 2.1930 2192982

Imidacloprid Rat: SD 10 1 43.5 6 1 0.0383 38314

Indaziflam Dog 7.5 1 32.6 6 1 0.0383 38344

Iodosulfuron-methyl Dog 49 1 32.6 6 1 0.2505 250511

Iprodione Rat: SD 50 1 43.5 6 1 0.1916 191571

Isoxaben Rat: Wistar 200 1 45.2 6 1 0.7375 737463

Kasugamycin Rabbit 10 1 22.8 6 1 0.0731 73099

Lactofen Rabbit 5 1 22.8 6 1 0.0365 36550

Linuron Rat: SD 5.8 1 43.5 6 1 0.0222 22222

Mandipropamid Rat: SD 41 1 45.2 6 1 0.1512 151180

MCPA Rat: SD 4.4 1 45.2 6 1 0.0162 16224

MCPB Rabbit 5 1 22.8 6 1 0.0365 36550

Mepiquat-Chloride Dog 58.4 1 32.6 6 1 0.2986 298569

Mesotrione Rat: SD 100 1 43.5 6 1 0.3831 383142

Metaflumizone Rat: Wistar 20 1 45.2 6 1 0.0737 73746

Metalaxyl Rat: SD 40 1 43.5 6 1 0.1533 153257

Metaldehyde Dog 30 1 32.6 6 1 0.1534 153374

Metconazole Fischer 6.4 1 47 6 1 0.0227 22695

Methidathion Rat: SD 0.2 1 45.2 6 1 0.0007 737

Methoxyfenozide Dog 16.8 1 32.6 6 1 0.0859 85890

Metolachlor Rat: SD 50 1 43.5 6 1 0.1916 191571

Metrafenone Rat: SD 79 1 43.5 6 1 0.3027 302682

Metsulfuron Rat: SD 34 1 43.5 6 1 0.1303 130268

Metsulfuron Rat: SD 34 1 43.5 6 1 0.1303 130268
Draft for Comment Version – March 1, 2014

5

Appendix Table B1: Inhalation Equivalent Concentration Calculations

Chemical Species: Strain

NOAEL 

(mg/kg/day) A CF D (hours) AF

IEC 

(mg/L)

IEC 

(ug/m3)

Myclobutinol Rat: SD 10 1 43.5 6 1 0.0383 38314

Napropamide Rat: SD 30 1 43.5 6 1 0.1149 114943

Nicosulfuron Dog 125 1 32.6 6 1 0.6391 639059

Nitrapyrin Rabbit 10 1 22.8 6 1 0.0731 73099

Norflurazon Rabbit 10 1 22.8 6 1 0.0731 73099

Novaluron Rat: SD 4.38 1 43.5 6 1 0.0168 16782

Novaluron Rat: SD 4.38 1 43.5 6 1 0.0168 16782

Orthosulfamuron Rat: Wistar 88.6 1 45.2 6 1 0.3267 326696

Oryzalin Rabbit 25 1 22.7 6 1 0.1836 183554

Oxyflourfen Rabbit 30 1 22.7 6 1 0.2203 220264

Paraquat dichloride Rat: SD 1.25 1 43.5 6 1 0.0048 4789

PBO Rat: SD 630 1 43.5 6 1 2.4138 2413793

PCNB Rat: Wistar 1 1 45.2 6 1 0.0037 3687

PCNB Rat: SD 1 1 43.5 6 1 0.0038 3831

Pendimethalin Rat: SD 10 1 43.5 6 1 0.0383 38314

Penoxsulam Dog 17.8 1 32.6 6 1 0.0910 91002

Phenmedipham Rat: Wistar 24 1 45.2 6 1 0.0885 88496

Phorate Rat: SD 0.25 1 43.5 6 1 0.0010 958

Phosmet Rat: SD 0.6 1 43.5 6 1 0.0023 2299

Picloram Rat: Fischer 344 50 1 47 6 1 0.1773 177305

Primisulfuron-methyl Rat: SD 50 1 43.5 6 1 0.1916 191571

prodiamine Rat: SD 7.2 1 43.5 6 1 0.0276 27586

Prohexadione calcium Rabbit 40 1 22.8 6 1 0.2924 292398

Prometryn Rabbit 12 1 22.8 6 1 0.0877 87719

Pronamide Rabbit 8.46 1 22.8 6 1 0.0618 61842

Propachlor Rat: SD 175 1 43.5 6 1 0.6705 670498

Propamocarb Rat: SD 65.41 1 43.5 6 1 0.2506 250613

Propanil Rat: SD 9 1 43.5 6 1 0.0345 34483

Propazine Rat: Wistar 6.25 1 45.2 6 1 0.0230 23046

Propiconazole Rat: Wistar 30 1 45.2 6 1 0.1106 110619

Propoxycarbazone-sodium Rabbit 100 1 22.8 6 1 0.7310 730994

Prosulfuron Dog 5.3 1 32.6 6 1 0.0271 27096

Prothioconazole Rabbit 2 1 22.8 6 1 0.0146 14620

Pymetrozine Rat: SD 8.1 1 43.5 6 1 0.0310 31034

Pyraflufen-ethyl Rabbit 20 1 22.8 6 1 0.1462 146199

Pyrasulfotole Rat: Wistar 1 1 45.2 6 1 0.0037 3687

Pyridalyl Rat: SD 2.8 1 43.5 6 1 0.0107 10728

Pyridate Dog 20 1 32.6 6 1 0.1022 102249

Pyrimethanil Rat: SD 23.1 1 43.5 6 1 0.0885 88506
Draft for Comment Version – March 1, 2014

6

Appendix Table B1: Inhalation Equivalent Concentration Calculations

Chemical Species: Strain

NOAEL 

(mg/kg/day) A CF D (hours) AF

IEC 

(mg/L)

IEC 

(ug/m3)

Pyrithiobac Rat: SD 58.7 1 43.5 6 1 0.2249 224904

Pyroxsulam Mouse 100 1 69.5 6 1 0.2398 239808

Quinclorac Rabbit 75 1 22.8 6 1 0.5482 548246

Quinoxyfen Rat: SD 20 1 43.5 6 1 0.0766 76628

Quizalofop Rat: SD 0.9 1 43.5 6 1 0.0034 3448

Rimsulfuron Dog 6.25 1 32.6 6 1 0.0320 31953

Saflufenacil Rat: SD 5 1 43.5 6 1 0.0192 19157

Simazine Rat: Wistar 6.25 1 45.2 6 1 0.0230 23046

Sodium Acifluorfen Rat: SD 20 1 43.5 6 1 0.0766 76628

Spinetoram Dog 2.49 1 32.6 6 1 0.0127 12730

Spinosad Dog 2.49 1 32.6 6 1 0.0127 12730

Spirodiclofen Dog 8.4 1 32.6 6 1 0.0429 42945

Spirodiclofen Dog 8.4 1 32.6 6 1 0.0429 42945

Spirotetramat Rabbit 10 1 22.8 6 1 0.0731 73099

Sulfentrazone Rat: SD 10 1 43.5 6 1 0.0383 38314

Sulfosate Dog 25 1 32.6 6 1 0.1278 127812

Sulfosulfuron Rat: SD 24 1 43.5 6 1 0.0920 91954

Tebuconazole Rat: SD 8.8 1 43.5 6 1 0.0337 33716

Tebufenozide Dog 2 1 32.6 6 1 0.0102 10225

Tembotrione Rat: Wistar 0.8 1 45.2 6 1 0.0029 2950

Tepraloxydim Rat: SD 40 1 43.5 6 1 0.1533 153257

Terbacil Rat: SD 2 1 43.5 6 1 0.0077 7663

Thiabendazole Rat: SD 10 1 43.5 6 1 0.0383 38314

Thiamethoxam Rat: Wistar 1.2 1 45.2 6 1 0.0044 4425

Thiazopyr Dog 2 1 32.6 6 1 0.0102 10225

Thidiazuron Rabbit 25 1 22.8 6 1 0.1827 182749

Thiencarbazone Dog 159 1 32.6 6 1 0.8129 812883

Thifensulfuron methyl Rat: Wistar 7 1 45.2 6 1 0.0258 25811

Thiobencarb Rat: SD 2 1 43.5 6 1 0.0077 7663

Thiophanate-methyl Rabbit 10 1 22.8 6 1 0.0731 73099

Topramezone Rat: Wistar 0.4 1 45.2 6 1 0.0015 1475

Topramezone Rat: Wistar 0.4 1 45.2 6 1 0.0015 1475

Tralkoxydim Rat: Wistar 30 1 45.2 6 1 0.1106 110619

Triadimefon Rat: Wistar 3.4 1 45.2 6 1 0.0125 12537

Triallate Rabbit 5 1 22.8 6 1 0.0365 36550

Triasulfuron Rat: SD 100 1 43.5 6 1 0.3831 383142

Tribenuron methyl Rabbit 20 1 22.8 6 1 0.1462 146199

Triclopyr Rat: SD 5 1 43.5 6 1 0.0192 19157

Trifloxystrobin Rat: SD 3.8 1 43.5 6 1 0.0146 14559
Draft for Comment Version – March 1, 2014

7

Appendix Table B1: Inhalation Equivalent Concentration Calculations

Chemical Species: Strain

NOAEL 

(mg/kg/day) A CF D (hours) AF

IEC 

(mg/L)

IEC 

(ug/m3)

Trifloxysulfuron-sodium Rabbit 100 1 22.8 6 1 0.7310 730994

Triflumizole Rat: SD 3.5 1 43.5 6 1 0.0134 13410

Triflusulfuron Rat: SD 6.56 1 43.5 6 1 0.0251 25134

Trinexapec-ethyl Rabbit 60 1 22.8 6 1 0.4386 438596

Uniconazole Rat: SD 5 1 43.5 6 1 0.0192 19157

Vinclozolin Rat: Long Evans 3 1 44.2 6 1 0.0113 11312

Zoxamide Dog 48 1 32.6 6 1 0.2454 245399

NOAEL = No Observed Adverse Effect Level

A = Absorption – ratio of deposition and absorption in the respiratory tract compared to absorption by the oral route 

(assumed to be equal)

CF = Conversion factor which accounts for respiratory volume and body weight for a given species/strain

D = Duration of exposure for animal

AF = Activity factor (default is 1)

IEC = Inhalation equivalent concentration