```

[Federal Register Volume 89, Number 220 (Thursday, November 14, 2024)]
[Notices]
[Pages 90019-90020]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2024-26451]

-----------------------------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES

National Institutes of Health

Government Owned Inventions Available for Licensing or 
Collaboration: Single Source-Detector Separation Approach To Calculate 
Tissue Oxygen Saturation

AGENCY: National Institutes of Health, HHS.

ACTION: Notice.

-----------------------------------------------------------------------

SUMMARY: The National Institute of Child Health and Human Development 
(NICHD), an institute of the National Institutes of Health (NIH), 
Department of Health and Human Services (HHS), is giving notice of the 
licensing or collaboration opportunities for the inventions listed 
below, which are owned by an agency of the U.S. Government and are 
available for licensing and collaboration to achieve expeditious 
commercialization of results of federally-funded research and 
development.

FOR FURTHER INFORMATION CONTACT: Inquiries related to these licensing 
or collaboration opportunities should be directed to: Zarpheen Jinnah, 
Ph.D., Technology Transfer Manager, NCI, Technology Transfer Center, 
Email: [email protected] or Phone: 240-620-0586.

SUPPLEMENTARY INFORMATION: Tissue oxygen saturation (StO2) is an 
important parameter to assess oxygen delivery and uptake. Hypoxia, a 
term used to indicate inadequate StO2, is often seen in patients with 
cardiac problems, respiratory infections or pulmonary diseases. 
Prolonged hypoxia can damage vital organs such as the brain, lungs, and 
heart and can be fatal. Currently available tissue oximeters to monitor 
StO2 are expensive and cumbersome.
    NICHD has developed a novel method, which uses a single source-
detector separation to calculate StO2. With this technique, a simple 
tissue oximeter can be made with just a LED and a photodetector, which 
enables the development of a miniaturized device. As a result, it can 
be used independently or implemented on existing technologies to 
measure StO2 without any hardware modifications. It can be applied in 
wearable devices, implantable medicines or endoscopies to measure 
tissue oxygenation in different tissues such as muscle, brain, spinal 
cord, internal organs, fetus and placenta.
    This Notice is in accordance with 35 U.S.C. 209 and 37 CFR part 
404.
    NIH Reference Number: E-037-2023-0.
    Product Type: Device.
    Therapeutic Area(s): Respiratory, Neurology or Cardiac.
    Potential Commercial Applications:
     Miniaturized tissue oximeter for implantation or 
endoscopy.
     Measure tissue oxygen saturation.
     Multilayer tissue oximeter.
    Competitive Advantages:
     Simpler and more compact as it only requires a single 
light source such as LED and a single photodetector such as a 
photodetector to build a tissue oximeter.
     Multilayer measurement.
     Implementation with existing technologies without any 
hardware modifications.
    Publication: Nguyen, T., et al. Application of the Single Source--
Detector Separation Algorithm in Wearable Neuroimaging Devices: A Step 
toward Miniaturized Biosensor for Hypoxia Detection. (PMID 38671806).

[[Page 90020]]

    Patent Status: PCT Application PCT/US2023/085725 filed on December 
22, 2023.
    Development Stage: Clinical Phase I.

    Dated: November 8, 2024.
Richard U. Rodriguez,
Associate Director, Technology Transfer Center, National Cancer 
Institute.
[FR Doc. 2024-26451 Filed 11-13-24; 8:45 am]
BILLING CODE 4140-01-P
```