EPA BIOPESTICIDES AND POLLUTION PREVENTION DIVISION 

COMPANY NOTICE OF FILING FOR PESTICIDE PETITIONS PUBLISHED IN 

THE FEDERAL REGISTER 

EPA Biopesticides and Pollution Prevention Division contact: [Colin Walsh (703) 

308-0298] 

INSTRUCTIONS: Please utilize this outline in preparing the pesticide petition. In 

cases where the outline element does not apply, please insert “NA-Remove” and 

maintain the outline. Please do not change the margins, font, or format in your 

pesticide petition. Simply replace the instructions that appear in green, i.e., “[insert 

company name],” with the information specific to your action.

SUBMISSION: E-mail the completed template to: hollis.linda@epa.gov.

TEMPLATE: 

[AMVAC Chemical Corporation

[Insert petition number]

 EPA has received a pesticide petition ([insert petition number]) from [AMVAC 

Chemical Corporation [4695 MacArthur Court, Ste. 1250, Newport Beach, CA 

90660] proposing, pursuant to section 408(d) of the Federal Food, Drug, and Cosmetic 

Act (FFDCA), 21 U.S.C. 346a(d), to amend 40 CFR part 180.

(Options (pick one)

 

 2. to establish an exemption from the requirement of a tolerance for 

(Options (pick one)

 2. biochemical pesticide 3-Decen-2-one

in or on potatoes.

Pursuant to section 408(d)(2)(A)(i) of FFDCA, as amended, AMVAC Chemical 

Corporation has submitted the following summary of information, data, and arguments 

in support of their pesticide petition. This summary was prepared by AMVAC Chemical 
2

Corporation, and EPA has not fully evaluated the merits of the pesticide petition. The 

summary may have been edited by EPA if the terminology used was unclear, the 

summary contained extraneous material, or the summary unintentionally made the reader 

conclude that the findings reflected EPA’s position and not the position of the petitioner. 

I. AMVAC Chemical Corporation, Petition Summary

 [Insert petition number]

A. Product Name and Proposed Use Practices

AMV 1018 Technical, AMV-1018 EP contain the biochemical, 3-decen-2-one 

which inhibits potato sprouting. 

B. Product Identity/Chemistry 

 1. Identity of the pesticide and corresponding residues. 3-Decen-2-one is 

naturally occurring in yogurt, tuna, porcini mushrooms, Iberico ham, fruits, spices 

and other food commodities. 3-Decen-2-one is approved as a direct and indirect 

food additive per 21 CFR 172.515. From studies, residues of 3-Decen-2-one are not 

of toxicological concern. 

 2. Magnitude of residues at the time of harvest and method used to determine the 

residue. NA-remove 

 3. A statement of why an analytical method of detecting and measuring the levels 

of the pesticide residue are not needed. NA-remove

C. Mammalian Toxicological Profile

Acute toxicity studies conducted with AMV-1018 Technical (98.0% active 

ingredient) showed no adverse effects by oral, dermal, and inhalation routes of 

exposure. Rats exposed to structurally similar surrogate compounds for 90-days 

exhibited no adverse effects at the highest doses tested. 3-Decen-2-one is 

metabolized to innocuous components, and the long history of dietary exposure is 

not associated with toxicity. 

D. Aggregate Exposure

 1. Dietary exposure. 

 i. Food. The acute oral toxicity study conducted with AMV-1018 Technical 

resulted in the LD50 of greater than 5,000 mg/kg of body weight. Structurally similar 

surrogate compounds administered to rats in the diet for 90-days did not cause 

adverse effects at the highest doses tested. These result support the perspective 

that residues of 3-Decen-2-one are not of toxicological concern following acute or 

repeated exposure via the diet. 
3

 ii. Drinking water. NA-Remove

 2. Non-dietary exposure. NA-Remove

E. Cumulative Effects

 No cumulative effects from the use of 3-Decen-2-one on potatoes are expected 

due to the low toxicity and residue profiles.

F. Safety Determination

 1. U.S. population. There are no safety concerns for using 3-Decen-2-one on 

potatoes on the U.S. population. The results of toxicity testing and the lack of 

residues of toxicological concern on treated potatoes show there is minimal risk to 

human health from 3-decene-2-one. 

 2. Infants and children. There are no safety concerns for using 3-Decen-2-one

on potatoes for infants and children. The results of toxicity testing and the lack of 

residues of toxicological concern on treated potatoes show there is minimal risk to 

infants and children from 3-decene-2-one. 

G. Effects on the Immune and Endocrine Systems 

 There are no reported adverse effects to the immune or endocrine systems 

from 3-Decen-2-one.

H. Existing Tolerances

 There are no existing tolerances for 3-Decen-2-one in the United States.

I. International Tolerances

 There are no existing international tolerances for 3-Decen-2-one.