<PAGE>



                                                                  EXHIBIT 10.6

                  EMPLOYMENT AGREEMENT FOR DR. GILLES CLOUTIER

         THIS EMPLOYMENT AGREEMENT ("Agreement") is entered into as of the 1st
day of April, 2001 (the "Effective Date"), by and among MoliChem Medicines,
Inc., a Delaware corporation ("MLCM") with its mailing address at 207 South
Elliott Road, PMB No. 231, Chapel Hill, North Carolina 27514, MoliChem R&D,
Inc., a North Carolina corporation (the "Company") with its mailing address at
207 South Elliott Road, PMB No. 231, Chapel Hill, North Carolina 27514 and Dr.
Gilles Cloutier, an individual residing at 100 Chestnut Road, Chapel Hill, North
Carolina 27514 ("Employee"). MLCM, the Company and Employee may be referred to
herein collectively as the "Parties" and individually as a "Party".

                                    RECITALS

         A. The Company wishes to employ Employee and Employee desires to be
employed by the Company in a position of trust and confidence to aid the Company
in its business; and

         B. Prior to employment of Employee, as a condition of employment, and
as part of the initial financial compensation established for Employee, the
parties wish to establish the terms of employment and their respective rights in
and to use certain proprietary and confidential information and intellectual
property, and to enter into an understanding regarding the use of the Company's
assets, information and goodwill to compete with the Company; and

         C. The Company has informed Employee that entering into this Agreement
is a condition of initial employment and the Company would not employ Employee
unless Employee agreed to the terms of this Agreement.

         NOW, THEREFORE, in consideration of the premises, the mutual covenants
contained herein, and other good and valuable consideration, the parties agree
as follows:

         1. Term. The employment created by this Agreement shall be for a two
(2) year term beginning on the Effective Date (the "Term"), and shall
automatically renew for additional one (1) year periods upon the anniversary
date of the initial term and each renewal term, subject, however, to earlier
termination as provided in Section 8 below.

         2. Duties. Employee is initially engaged to act in the capacity of
Chief Business Officer, subject to change as appropriate to the needs of the
Company. Employee's duties and powers as Chief Business Officer shall be
determined from time to time by the Board of Directors of the Company. The
Company and Employee understand and agree that Employee is a part-time employee
and is obligated to provide the Company with a minimum of two (2) days of
service per week. Employee may perform his duties at the Company facilities, the
Employee's home offices (located in both Employee's permanent and temporary
residences) or any other remote location mutually agreed upon by Employee and
Company.




                                     E-109
<PAGE>



          3. Base Compensation. Subject to the terms and conditions of this
Agreement, as partial compensation for services rendered and Employee's
covenants and agreements under this Agreement, the Company shall pay to Employee
a base salary of ninety thousand dollars ($90,000) per year, payable in
accordance with the Company's standard practices. All applicable federal and
state taxes and other governmental assessments shall be deducted from Employee's
salary, as required by law.

          4. Additional Compensation. In addition to the compensation specified
in Section 3 above, Employee shall have the opportunity to earn an annual bonus
in the amount of twenty percent (20%) of base compensation and shall be eligible
for other incentive compensation payments, in accordance with such plans as may
be adopted by the Board of Directors of the Company.

          5. Options. In addition to the compensation under Sections 3 and 4
above, Employee shall be awarded a fully vested option for three hundred fifty
thousand (350,000) shares of the common stock of MLCM at a purchase price of one
dollar and fifty cents ($1.50) per share pursuant to the Option Agreement in the
form of Exhibit A.

         6.       Benefit Plans.

                  A. Personal Leave. Employee shall be entitled to six (6) days
(or an equivalent of three weeks of service) of paid personal leave per calendar
year, which shall accrue at the rate of one and one-half (1.5) days per quarter.
Vacation days not used in one calendar year shall not carry over to the
following calendar year. No compensation shall be due for unused vacation days
that do not carry over.

                  B. Sick Leave. Employee shall be entitled to four (4) days of
sick or personal leave each calendar year, which shall accrue at the rate of one
(1) day per quarter. Sick leave may be used with respect to illness of Employee
or to attend to illness of any member of Employee's immediate family who resides
with Employee. No payment shall be made for unused sick and personal leave upon
termination of Employee's employment.

                  C. Leave Policies. The Company may at its sole option change
its vacation or sick and personal leave policy by providing a new policy in
writing to Employee and specifically referencing it as an amendment to this
Agreement, such amendment to be prospective only.

                  D. Holidays. Employee shall be entitled to such paid holidays
as are provided to other employees of the Company.

                  E. Insurance. The Company shall make available, at Employee's
expense, the standard health, life and disability coverage provided to other
employees, which coverage may vary from time to time or may be eliminated
provided that Employee is treated the same as other employees similarly
situated.

                  F. Other Benefits. Employee shall be entitled to participate
in any other group benefit plans or arrangements made available to the Company's
Employees in the future, subject to and on a basis consistent with the terms,
conditions and overall administration of such plans and



                                     E-110
<PAGE>


arrangements. Nothing paid to Employee under any plan or arrangement shall be
deemed to be in lieu of compensation payable to Employee pursuant to Section 3.
Notwithstanding the foregoing, Employee shall not be entitled to such benefit if
the benefit provided does not provide such coverage to part-time employees
working the amount of time as Employee, and the Company is not reasonably able
to obtain, at comparable cost, another benefit provider.

         7. Expenses. The Company shall reimburse Employee for business expenses
directly and reasonably incurred in the performance of his duties provided that
Employee complies with the Company's policies concerning reimbursement for such
expenses.

         8. Termination.

                  A. Employee may terminate his employment at any time upon
giving one (1) month's prior written notice to the Company.

                  B. The Company may terminate Employee at any time for any
reason upon one (1) month's prior written notice to Employee.

                  C. In the event, (i) Company terminates Employee pursuant to
Section 8.b., (ii) the Employee terminates his employment as a result of his
title or duties being materially diminished, other than for good cause, or (iii)
Employee's position is eliminated as a result of a "change of control" (as
defined below), Employee shall be entitled to a severance payment in the amount
of six (6) months salary to be paid in regular monthly installments.

         For the purpose of this Agreement, "change of control" shall be deemed
to have occurred when, as a result of any merger, consolidation, reorganization
or other similar event, the shareholders of Company immediately prior to such
event own less than fifty percent (50%) of the outstanding securities of the
resulting entity immediately after such event.

                  D. The Company may terminate Employee immediately and without
payment of severance upon the happening of the following:

                           (i) Disability. In the event that (i) Employee is
totally and permanently disabled as determined in accordance with the Company's
long-term disability plan, if any, as in effect at such time, or (ii) if no such
plan is in effect, Employee is unable to perform his duties and responsibilities
hereunder by reason of illness, injury or incapacity for ninety (90) consecutive
days, this Agreement may be terminated by the Company, and the Company shall
have no further liability or obligation to Employee for compensation hereunder;
provided, however, that Employee shall continue to be compensated as provided in
Section 3 of this Agreement during such 90-day period and until termination
under this Section, and provided further, that Employee will be entitled to
receive the payments prescribed under any disability benefits plan in which
Employee was participating.


                           (ii) Death. In the event that Employee dies during
the Term, the Company shall pay to his executors, legal representatives or
administrators an amount equal to the remaining installment of Employee's
compensation set forth in Section 3 hereof for the month in which




                                     E-111
<PAGE>


Employee dies, and thereafter the Company shall have no further liability or
obligation hereunder to Employee's executors, legal representatives,
administrators, heirs or assigns or any other person claiming under or through
Employee; provided, however, that Employee's heirs, legal representatives or
administrators will be entitled to receive the payments prescribed under any
death or disability benefits plan of the Company in which Employee was
participating.

                           (iii) Cause. Nothing in this Agreement shall be
construed to prevent Employee's termination by the Company at any time for
"cause". For purposes of this Agreement, "cause" shall mean (i) the failure of
Employee to perform or observe (other than by reason of illness, injury or
incapacity) any of the material terms or provisions of this Agreement, (ii)
dishonesty or misconduct on the part of Employee that is or is reasonably likely
to be materially damaging or materially detrimental to the business of the
Company, (iii) conviction of a felony, (iv) failure to comply with the
reasonable directions of the Board of Directors or officers of the Company in a
way that is materially damaging or materially detrimental to the business of the
Company, or (v) failure to perform his material duties under this Agreement due
to abuse of alcohol or drugs. Prior to terminating this Agreement on account of
Employee's failure to perform or observe any of the material terms and
conditions of this Agreement (as described in clauses (i), (iv) or (v) of the
preceding sentence), the Company shall give Employee thirty (30) days' written
notice and an opportunity to cure such failure to the satisfaction of the
Company. Upon termination for cause, the Company shall pay to Employee all sums
due Employee through the date of such termination. Following such termination,
the Company shall have no further duty or obligation to Employee.

                  D. Notwithstanding any such termination, the obligations and
restrictions imposed on the Employee pursuant to Sections 9 through 14 and
Sections 21, 22, 23 and 27 shall survive termination of this Agreement and shall
exist in accordance with the terms of those Sections.

          9. Confidential Information. Employee may gain access to or knowledge
of information about the Company that is not generally known or available to the
public ("Confidential Information"). Such information may include trade secrets,
research, development, client information, marketing plans, contractual
arrangements, personnel records, finances, and client lists. Employee will not
disclose any Confidential Information during or after the term of this Agreement
to any person, firm, corporation, association or other entity for any reason or
purpose whatsoever or use such information except as directed or authorized by
the Company. All Confidential Information remains the property of the Company
and no license or other rights to Confidential Information is granted hereby. On
demand of the Company, at any time, Employee shall immediately deliver all
printed or written Confidential Information to the Company.

                  The following information shall not be deemed part of the
Confidential Information: (1) that was in the public domain at the time of
disclosure by the Company to the Employee; or (2) that entered the public domain
through no fault of Employee subsequent to the time of disclosure by the Company
to Employee; or (3) that was in the Employee's possession free of any obligation
of confidence at the time of disclosure by the Company; or (4) that was
rightfully communicated by a third party to Employee free of any obligation of
confidence subsequent to the time of disclosure by the Company to Employee; or
(5) that is deemed not confidential by the Board of Directors of the Company or
is not confidential under any confidentiality policies adopted by the Board of
Directors of the Company.




                                     E-112
<PAGE>



          10. Ownership of Confidential Information and Work Product. Except as
limited by this Section, Employee agrees that all Confidential Information and
all other work product of any type or nature created by Employee or resulting
from work performed by Employee for the Company, using the Company's facilities,
equipment, supplies or other property, during business hours, or related to the
Company's Business (defined below), even if not Confidential Information (such
Confidential Information and work product being defined as "Work Product"),
shall belong to the Company exclusively and without any additional compensation
to Employee. Employee agrees that any original copyrightable Work Product shall
be considered as "works made for hire," and that the Company shall be deemed the
author thereof, provided that to the extent such Work Product is determined not
to constitute "works made for hire" as a matter of law, Employee hereby
irrevocably assigns and transfers to the Company all rights in and to such Work
Product. For the purpose of this Agreement, it is understood by Employee that
the "Company's Business" includes, without limitation, development and
commercialization of treatments for respiratory diseases, including but not
limited to cystic fibrosis, chronic obstructive pulmonary disorders,
tuberculosis, chronic bronchitis and related diseases and treatment of sepsis,
ARDS and related diseases. Any notification of Employee by the Company, oral or
written, or any reasonable knowledge on the part of Employee that the Company's
Business includes other specific aspects shall expand Employee's obligations
under this Agreement to include those additional aspects of the Company's
Business.

         Upon request Employee will execute any instrument required to vest in
the Company complete title and ownership to all Work Product, and will, at the
request and expense of the Company, execute any instruments necessary to obtain
legal protection in the United States and foreign countries for all Work Product
and for the purpose of vesting title thereto in the Company, or its nominee, all
without any additional compensation of any kind to Employee.

         11. Disclosure to the Company. Upon the conception of any Work Product
by Employee (either solely or in conjunction with others) and without waiting to
perfect or complete it, Employee promises and agrees immediately to fully
disclose to an officer of the Company, and to no one else, and thereafter to
treat the Work Product as the property and secret of the Company. This shall
include Work Product made, conceived or reduced to practice after the term of
Employee's employment but which belong to the Company pursuant to Sections 10
and 18. Upon request Employee will reduce any concept in the Work Product to
writing and deliver all copies of the writing to the President of the Company,
or if Employee is the President of the Company, such copies shall be delivered
to the Secretary of the Company. These obligations shall continue beyond the
termination of employment with respect to Work Product conceived or made during
the period of employment.

         12. Collaboration. Employee warrants that Employee will disclose the
participation of any other person in any of Employee's work for the Company.
Absent such disclosure, Employee warrants that all work performed by Employee
will be Employee's own and that no other person shall have any right, title, or
interest in any work submitted to the Company.

         13. Records. Employee agrees that Employee will keep and maintain
adequate and current written records of all Work Product created by Employee.
All written records relating to any Work Product, whether in the form of notes,
data, reference materials, sketches, drawings,




                                     E-113
<PAGE>


memoranda, correspondence, blueprints, manuals, letters, notebooks, reports,
flowcharts, programs, proposals, or any other form, and whether in written,
electronic or other media, concerning the Company's Business or incorporating or
reflecting any of the Work Product, shall be and remain the property of and
available to the Company at all times, and shall be delivered to the Company on
demand or upon Employee leaving the Company's service. The Company may, at any
time and without notice to Employee, take possession of such records regardless
of their location, including Employee's files, desk, computer or other areas
under the control of the Company.

         14. Assistance After Employment. Employee agrees that if, subsequent to
Employee's employment by the Company, his assistance is needed in regard to
securing, defending, or enforcing any patent or copyright of which Employee is
an inventor, co-inventor, author or co-author Employee shall provide requested
assistance and the Company shall pay reasonable compensation for his time at a
rate to be agreed upon but not higher than 150% of the last salary rate paid to
Employee by the Company during his employment, together with full reimbursement
of reasonable and necessary directly-related expenses.

         15. Third-Party Obligations. Employee acknowledges that the Company
from time to time may have agreements with other person or entities or with
government or other agencies that impose obligations or restrictions on the
Company regarding Inventions, Confidential Information or Work Product created
by Employee or the Company during the course of work thereunder, or regarding
the confidential nature of the work or confidential information of the third
party disclosed during or used as part of such work. Employee agrees to be bound
by all such obligations and restrictions and to take all action necessary to
discharge the obligations of the Company thereunder.

         16. Notices. Any notices to be given hereunder by either Party to the
other may be effected in writing either by personal delivery, via telefacsimile
or by mail, registered or certified, postage prepaid with return receipt
requested to the addresses set forth above, provided however, each Party may
change the address by written notice in accordance with this Section 16. Notices
delivered personally or by telecopier (with answerback received) shall be deemed
communicated as of actual receipt mailed notices shall be deemed communicated as
of three days after mailing.

         17. Noncompetition. Employee agrees that during the term of this
Agreement and for a period of one (1) year after the last payment from the
Company to Employee has been delivered, Employee will not, without the prior
written consent of the Company (which consent may be withheld for any reason),
provide services, within the United States and in locations where Company
customers are located, substantially similar to the services to be provided by
Employee under this Agreement to any person or entity engaged in a business
which is substantially similar to the Company's Business, or which can
reasonably be expected to compete with the Company's Business. Notwithstanding
anything herein which may be construed to the contrary, Employee shall be free
to use and employ Employee's general skills, know-how and expertise, and to use,
disclose and employ any generalized ideas, concepts, know-how, methods,
techniques or skills gained or learned during the course of providing the
services hereunder, so long as Employee acquires and applies this information
without disclosure of any Confidential Information of the Company and without
violating the terms of this Section 17. The term of this noncompetition covenant
shall be tolled during any period of actual competition by the Employee and/or
any period of litigation required to enforce the Employee's obligations under
this Agreement. The Company acknowledges



                                     E-114
<PAGE>


that the Employee is a part-time employee of United Therapeutics Corporation and
Northern Therapeutics Corporation, and the Company agrees that Employee's work
for such companies, as of the Effective Date, does not fall within the scope of
services that competes with the Company's Business; provided however, in the
event the scope of the services provided by Employee to such companies or the
scope of the Company's Business change such that the services provided by
Employee to such companies or other third parties compete with the Company's
Business, the provision of this Paragraph with respect to noncompetition will
apply and may be enforced by the Company.

         18. Warranty by Employee. Employee represents and warrants that his
performance of all terms under this Agreement does not result in a breach of any
duty owed by Employee to another, under contract or otherwise, or violate any
confidence of another. Employee agrees not to disclose to the Company or induce
the Company to use any confidential or proprietary information belonging to any
of the Employee's previous employers or others. Employee warrants that Employee
has executed no prior noncompetition, nondisclosure or confidentiality
agreements that would in any way interfere with his work for or employment by
the Company. Employee agrees to notify the Company in writing before Employee
makes any disclosure to or performs any work on behalf of the Company which
appears to threaten or conflict with any proprietary right Employee claims in
any Work Product and in the event of Employee's failure to give such notice,
Employee shall make no claim against the Company with respect to any such Work
Product.

         19. Exit Interview. Employee agrees that upon termination of Employee's
employment for any reason, Employee shall participate in an exit interview with
Company personnel. At or prior to the time of this interview Employee shall
deliver to the Company all notes, data, reference materials, sketches, drawings,
memoranda, correspondence, manuals, letters, notebooks, reports, programs,
proposals, or any other documents, whether in written, electronic or other
media, concerning the Company's Business or incorporating or reflecting any of
the Confidential Information or Work Product. Employee agrees that, upon
request, Employee will execute a sworn statement that Employee has complied with
the terms of this Section, and that should Employee fail to execute such a
statement the Company may withhold any and all amounts due to Employee for any
reason, except minimum compensation required by law.

         20. Extraordinary Relief. Nothing in this Agreement shall be construed
as prohibiting the Company from pursuing all remedies available to the Company
for breach of this Agreement. Employee recognizes and agrees that because of the
unique nature of the Confidential Information and the competitive position of
the Company his breach of this Agreement will irreparably injure the Company,
for which the Company could not adequately be compensated by remedies at law.
Should Employee at any time reveal or use for the benefit of other than the
Company or threaten to so reveal or use any Confidential Information in
violation of Section 9, or during any restricted period violate or threaten to
violate any of the restrictions in Section 17, the Company shall be entitled to
an injunction restraining Employee from doing or continuing to do or performing
any such acts, and Employee hereby consents to the issuance of such injunction
against Employee. Employee further agrees to waive any bond requirement that may
arise if the Company is forced to seek injunctive relief to enforce the terms of
this Agreement.



                                     E-115
<PAGE>

         21. Accounting for Profits; Indemnification. Employee covenants and
agrees that if Employee shall violate any of Employee's covenants or agreements
under this Agreement, the Company shall be entitled to an accounting and
repayment of all profits, compensation, royalties, commissions, remunerations or
benefits which Employee directly or indirectly shall have realized or may
realize relating to, growing out of or in connection with any such violation;
such remedy shall be in addition to and not in limitation of any injunctive
relief or other rights or remedies to which the Company is or may be entitled at
law or in equity or otherwise under this Agreement. Employee hereby agrees to
defend, indemnify and hold harmless the Company against and in respect of: (i)
any and all losses and damages resulting from, relating or incident to, or
arising out of any misrepresentation or breach by Employee of any warranty,
covenant or agreement made or contained in this Agreement; and (ii) any and all
actions, suits, proceedings, claims, demands, judgments, payments, costs and
expenses (including reasonable attorneys' fees) incident to the foregoing.

         22. Successor Employers. Employee hereby authorizes the Company to
provide a copy of this Agreement, including any Exhibits, to any and all future
employers, and to notify any and all future employers that the Company intends
to exercise its legal rights arising out of or in conjunction with the Agreement
and/or any breach or any inducement of breach of it.

         23. Reasonableness and Enforceability. EMPLOYEE HAS READ AND CAREFULLY
CONSIDERED THE TERMS OF THIS AGREEMENT, HAS HAD THE OPPORTUNITY TO CONTACT
EMPLOYEE'S OWN LEGAL COUNSEL TO ADVISE EMPLOYEE REGARDING THE TERMS OF THIS
AGREEMENT, AND EMPLOYEE NOW AGREES THAT THE TERMS OF THIS AGREEMENT ARE FAIR AND
REASONABLE AND ARE REASONABLY REQUIRED FOR THE PROTECTION OF THE INTEREST OF THE
COMPANY AND ITS MEMBERS. EMPLOYEE FURTHER AGREES THAT THE RESTRICTIONS AND
COVENANTS OF THIS AGREEMENT WILL NOT IMPAIR THE ABILITY OF EMPLOYEE TO SECURE
EMPLOYMENT SO AS TO BE ABLE TO MAKE A REASONABLE LIVING. The provisions of this
Agreement shall be enforceable notwithstanding the existence of any claim or
cause of action of Employee against the Company whether predicated on this
Agreement or otherwise. Failure of the Company to enforce
at any time or for any period of time any of the conditions or covenants of this
Agreement shall not be construed as a waiver of such provisions or of the right
of the Company to enforce subsequent breaches of the same or other conditions
and covenants, unless such permanent waiver is provided to Employee in writing
and signed by the President of the Company or, if Employee is the President of
the Company, such writing is to be signed by the Secretary of the Company.

         24. Reformation/Severability of Agreement. If any provision of this
Agreement shall for any reason be adjudged by any court of competent
jurisdiction or arbiter to be illegal, invalid or otherwise unenforceable, such
judgment shall not affect, impair or invalidate the remainder of this Agreement
but shall be confined in its operation to the provision of this Agreement
directly involved in the controversy in which such judgment shall have been
rendered. The invalid or unenforceable provision shall be reformed so that each
party shall have the obligation to perform reasonably alternatively to give the
other party the benefit of its bargain. In the event the invalid or
unenforceable provision cannot be reformed, the other provisions or applications
of this Agreement shall be given full effect, and the invalid or unenforceable
provision shall be deemed struck.



                                     E-116
<PAGE>


         25. Construction of Terms. Any reference herein to the masculine shall
include the feminine or neuter, and any reference herein to the singular or
plural may be construed as plural or singular wherever the context requires.

         26. Successor and Assigns. This Agreement shall inure to the benefit of
and be binding upon the Company, its successors and assigns, including without
limitation any entity which may acquire all or substantially all of the
Company's assets and business or into which the Company may be consolidated or
merged, and the Employee, his heirs, executors, administrators and legal
representatives. Employee may not assign any of his obligations under this
Agreement.

         27. Governing Law and Venue. This Agreement shall be governed by and
construed in accordance with the laws of North Carolina applicable to contracts
between residents of North Carolina which are wholly executed and performed in
North Carolina. Any lawsuit brought under the terms of this Agreement shall have
exclusive venue in the state and federal courts of Orange County, North
Carolina; provided, however, that with respect to any proceeding for injunctive
relief the Company may, at its option, bring the proceeding before a court where
Employee resides at the time of such proceeding.

         28. Merger. This Agreement constitutes the entire Agreement between the
parties with respect to the subject matter hereof; and supersedes and replaces
any oral or written communications and any undertakings otherwise made between
the parties relating to the subject matter. Except as specified in Section 24,
no changes, modifications, or amendments of any terms and conditions of this
Agreement are valid or binding unless agreed to in a writing signed by Employee
and the President of the Company or, if Employee is the President or the
Secretary of the Company.

         This Agreement is effective as of the date first above written and is
executed in duplicate originals.

                         [Signatures on following page]




                                     E-117
<PAGE>



MOLICHEM MEDICINES, INC.                    MOLICHEM R&D, INC.


By: ______________________________          By:_______________________________
         President                                   President

                                            EMPLOYEE:

                                            ----------------------------------
                                            Dr. Gilles Cloutier




                                     E-118
<PAGE>

                                                                       Exhibit A

                      NON-STATUTORY STOCK OPTION AGREEMENT


         This Nonstatutory Stock Option Agreement, dated as of June __, 2001
(this "Agreement") is entered into by and between MoliChem Medicines, Inc., a
Delaware corporation (the "Company") and Dr. Gilles Cloutier, an employee of
MoliChem R&D, Inc. ("R&D"), a wholly owned subsidiary of the Company
("Optionee").

                              W I T N E S S E T H:
                              - - - - - - - - - -

         WHEREAS, Optionee is now an employee of the Company's wholly owned
subsidiary MoliChem R&D, Inc., and the Company desires to afford employees of
its subsidiary the opportunity to acquire, or enlarge, their stock ownership in
the Company so that Optionee may have a direct proprietary interest in the
success of the Company and its subsidiary;

         NOW, THEREFORE, in consideration of the premises and of the mutual
covenants and agreements hereinafter set forth, the parties mutually covenant
and agree as follows:

         1. Grant of Option. Subject to the terms and conditions set forth
herein, Company grants to Optionee, during the period commencing with the date
of this Agreement and ending June __, 2011, unless terminated in accordance with
Paragraph 8 (the "Option Period"), the option to purchase from the Company (the
"Option"), at a price of one and a half dollars ($1.50) per share (the "Option
Price") three hundred and fifty thousand (350,000) shares of the Company's
Common Stock (the "Shares"). The Option granted herein is in connection with and
in furtherance of the Company's compensatory benefit plan for participation of
the Company's employees, officers, directors and consultants and is intended to
comply with the provisions of Rule 701 promulgated by the Securities and
Exchange Commission under the Securities Act. The Option granted herein is not
intended to be an "incentive stock option" under Section 422 of the Code.

         2. Exercise of Option

         (a) The Option may be exercised, from time to time, during the Option
Period, to purchase all or any portion of the number of Shares as follows:

                                                          Number of Shares that
Period from Date of Grant of the Option                   May be Purchased
---------------------------------------                   -----------------

On or after June __, 2001                                     350,000

         (b) No fewer than one hundred (100) Shares may be purchased upon any
one exercise of the Option, unless the number of Shares to be purchased at such
time is the total number of Shares remaining subject to the Option. Any exercise
of less than the total number of Shares identified in the Option shall be deemed
an exercise in part, and the Option may again be exercised at such time or times
determined by Optionee, provided that at such times the Option is still
exercisable.

         (c) In no event shall any option granted hereunder be exercisable for a
fractional share.



                                     E-119
<PAGE>


         (d) The Option is exercised by Optionee delivering to the Secretary of
the Company, on any business day, a written notice signed by Optionee specifying
the number of Shares to be purchased, together with the Option Price, in the
manner specified in Paragraph 4(a).

         (e) The Option, or any unexercised part thereof, shall not be
exercisable after expiration or termination of the Option Period.

         3. Termination of Employment. Termination of Employment shall not
affect the exercisability of this Option.

         4. Payment of Option Price and Related Taxes.

         (a) Payment in full of the Option Price must be made at the time the
Option is exercised, and shall be paid in U.S. dollars in cash or by certified
or bank check; provided, however, that in the discretion of the Committee, but
only after an Initial Public Offering has occurred, payment may be made by
surrendering shares of Common Stock of the Company owned by Optionee in one or
more sequential surrenders, regardless of whether such shares were acquired
pursuant to the exercise or partial exercise of the Option or any other option
and regardless of whether a stock certificate for such shares shall have been
received by Optionee. Shares received in payment shall be valued at Fair Market
Value as of the date of the exercise of the Option. Any overpayment shall
promptly be refunded in cash.

         (b) To the extent Optionee (or other person exercising this Option)
recognizes income as a result of the exercise of the Option, he or she shall pay
the Company an amount equal to the federal, state and local withholding taxes on
income so recognized within ten (10) days of the exercise of the Option.

         5. Issuance of Shares.

         (a) Within fifteen business days after receiving notice of exercise and
payment of the aggregate Option Price, and subject to Optionee's payment or
arrangement for payment of the applicable taxes as specified in Paragraph 4(b),
the Company shall issue to Optionee the number of Shares with respect to which
the Option was exercised, and shall deliver to Optionee, a certificate for such
Shares.

         (b) Notwithstanding anything to the contrary contained in this
Agreement, this Option may not be exercised if at any time the Board of
Directors determines it is necessary or desirable as a condition of, or in
connection with, the issuance of the Shares that (i) the Shares be listed,
registered or qualified upon any securities exchange or under any state or
federal law, or (ii) the consent or approval of any governmental authority be
received, then the issuance of the Shares may not be consummated in whole or in
part unless such listing, registration, qualification, consent or approval has
been effected or obtained free of any conditions not acceptable to the Board of
Directors. The inability of the Company to obtain from any regulatory body
having jurisdiction the authority deemed by the Company's counsel to be
necessary to the lawful issuance of any shares of its Common Stock hereunder
shall relieve the Company of any liability in respect of the nonissuance or sale
of such stock as to which such requisite authority shall not have been obtained.
Notwithstanding the foregoing, the Company shall not be required to register
under the Securities Act any Common Stock to be issued pursuant to exercise of
the Option.


                                     E-120
<PAGE>


         (c) Notwithstanding anything to the contrary contained in this
Agreement, if at any time specified herein for the issuance of shares to
Optionee, any law, or any regulation or requirement of the Securities and
Exchange Commission or any other federal, state or local governmental authority
having jurisdiction, shall require either the Company or Optionee to take any
action in connection with the shares then to be issued, the issuance of such
shares shall be deferred until such action shall have been taken. The Company
shall be under no obligation to take such action and the Company shall have no
liability whatsoever as a result of the non-issuance of such shares as a result
of not taking such action, except to refund to the Optionee any consideration
tendered in respect of the Option Price.

         6. Transfer of Option. This Option is not transferable by Optionee
except by will or intestate succession, and is exercisable during Optionee's
lifetime only by Optionee. No assignment or transfer of this Option or of the
rights represented thereby in contravention of the foregoing, whether voluntary
or involuntary, by operation of law or otherwise, shall vest in the assignee or
transferee any interest or right herein whatsoever. Immediately upon any attempt
to assign or transfer this Option, this Option shall terminate and be of no
force or effect.

         7. Adjustments Upon Changes in Capitalization or Mergers.

         (a) The Shares with respect to which this Option is granted are shares
of the Common Stock of the Company as constituted on the date of this Agreement,
but if, and whenever, prior to the delivery by the Company of all of the Shares
with respect to which this Option is granted, the Company shall pay a stock
dividend or effect a subdivision or combination of shares, or other capital
readjustment, then (i) in the event of any increase in the number of shares of
common stock outstanding, the number of Shares then remaining subject to the
Option shall be proportionately increased (except that any fraction of a share
resulting from any such adjustment shall be excluded from the operation of this
Agreement), and the Option Price payable per share shall be proportionately
reduced, and (ii) in the event of a reduction in the number of shares of Common
Stock outstanding, the number of Shares then remaining subject to the Option
shall be proportionately reduced (except that any fractional share resulting
from any such adjustment shall be excluded from the operation of this
Agreement), and the Option Price payable per share shall be proportionately
increased.

         (b) Upon a merger or consolidation of the Company with or into or with
one or more other corporations, or any other corporate reorganization of any
form involving the Company as a party and an exchange, conversion, adjustment or
other modification of the outstanding Common Stock, Optionee shall thereafter
have the right, upon exercise of the Option, provided that such Option is
currently exercisable and has not otherwise been terminated, to receive the kind
and amount of shares of stock or other securities or property to which Optionee
would have been entitled if Optionee had received Shares by exercise of the
Option immediately prior to or simultaneously with such merger or consolidation
or similar transaction, and the Option Price shall be adjusted accordingly.
Comparable rights shall accrue to Optionee in the event of successive
transactions of the type described above. These adjustments and the manner of
their application shall be determined by the Committee in its sole discretion.
Any such adjustments may provide for the elimination of fractional shares.

         8. Early Termination of Options.

         (a) Anything contained herein to the contrary notwithstanding, upon a
sale or transfer of all or substantially all of the assets of the Company or R&D
to another corporation (other than a



                                     E-121
<PAGE>


wholly-owned subsidiary), person or entity, or upon a distribution by the
Company of its assets as a liquidating or partial liquidating dividend with
respect to its Common Stock, or the happening of any other similar event
affecting its Common Stock, then following a determination by the Board of
Directors to effect or proceed with such event or transaction, the Board of
Directors, upon at least ten (10) days' written notice to the holder, may in its
sole discretion provide that such Option or any unexercised portion thereof
shall terminate as of the effective date of such event or transaction.

         (b) Anything contained herein to the contrary notwithstanding, upon the
happening of an "Initial Public Offering" (defined as an underwritten offering
of the Company's Common Stock pursuant to a registration statement under the
Securities Act of 1933, as amended, in which the net proceeds to the Company are
at least $5,000,000), then following a determination by the Board of Directors
to effect or proceed with the Initial Public Offering, the Board of Directors,
in its sole discretion, upon at least ten (10) days' written notice to the
holder, may provide that such Option or any unexercised portion thereof shall
terminate as of the effective date of the Initial Public Offering.

         (c) Anything contained herein to the contrary notwithstanding, in the
event of a merger or consolidation of the Company with or into any other
corporation or organization as a result of which the holders of the voting
capital stock of the Company prior to such merger or consolidation would receive
or hold less than a majority of the shares of voting capital stock of the
resulting or surviving corporation or organization, then, following a
determination by the Board of Directors to effect or proceed with such merger or
consolidation, the Board of Directors, upon at least ten (10) days' written
notice to the holder, may in its sole discretion provide that such Option or any
unexercised portion thereof shall terminate as of the effective date of such
merger or consolidation.

         9. Optionee Not Stockholder. Optionee shall not be deemed for any
purpose to be a stockholder of the Company with respect to any shares covered by
this Option unless this Option shall have been exercised and the Option Price
paid in the manner provided herein. No adjustment will be made for dividends or
other rights where the record date is prior to the date of exercise and payment.

         10. No Effect. Neither the Option granted hereunder nor this Agreement
shall affect in any way the right or power of the Company or its stockholders to
make or authorize any or all adjustments, recapitalization, reorganizations or
other changes in the Company's capital structure or its business, or any merger
or consolidation of the Company, or any issuance of bonds, debentures, preferred
or prior preference stocks ahead of or convertible into, or otherwise affecting
the common stock or the rights thereof, or the dissolution or liquidation of the
Company, or any sale or transfer of all or any part of its assets or business,
or any other corporate act or proceeding, whether of a similar character or
otherwise.

         11. Notices. Any notice which either party hereto may be required or
permitted to give to the other shall be in writing, and may be delivered
personally or by mail, postage prepaid, addressed as follows: (a) if to the
Company: MoliChem Medicines, Inc., 207 South Elliot Road, PMB No. 231, Chapel
Hill, North Carolina 27514, Attention President, or at such other address as the
Company, by notice to Optionee, may designate in writing from time to time; and
(b) if to Optionee, to Optionee's address appearing below or at such other
address as Optionee, by notice to the Company, may designate in writing from
time to time.

         12. Entire Agreement; Rights and Interest. This Non-Statutory Stock
Option Agreement, including its exhibits, and the Plan pursuant to which it was
issued, constitute the entire agreement of the parties with respect to the
matters covered hereby, and supersede any previous agreements,



                                     E-122
<PAGE>


whether written or oral. Each party hereby stipulates and acknowledges that
there are no other understandings, expectations or agreements, either written or
oral, respecting Optionee's rights and entitlements as a stockholder or option
holder of the Company, including, without limitation, any understandings,
expectations, or agreements regarding any employment, compensation or other
benefits, governance of the Company or the payment of dividends, except as
expressly set forth in Optionee's employment agreement with the Company, if any.
Optionee hereby covenants and agrees, for himself or herself and for his or her
successors and assigns, that no such understandings, expectations or agreements
which may hereafter arise shall be cognizable or enforceable unless the same
shall be reduced to a writing signed by the parties to be charged.

         IN WITNESS WHEREOF, the Company has caused this Agreement to be
executed by its duly authorized officer, and Optionee has hereunto set his or
her hand and seal, all on the day and year first above written.


                                              Molichem Medicines, Inc.
(CORPORATE SEAL)

                                              --------------------------------
                                              President

ATTEST:

---------------------------
Secretary
                                              OPTIONEE:


                                                                        (SEAL)
                                              --------------------------
                                              Dr. Gilles Cloutier
                                              100 Chestnut Road
                                              Chapel Hill, North Carolina 27514




                                     E-123