[Federal Register Volume 89, Number 208 (Monday, October 28, 2024)]
[Notices]
[Pages 85537-85538]
From the Federal Register Online via the Government Publishing Office [www.gpo.gov]
[FR Doc No: 2024-24983]


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DEPARTMENT OF HEALTH AND HUMAN SERVICES

Centers for Disease Control and Prevention

[Docket Number CDC-2024-0085, NIOSH-153-F]


Request for Public Comment on the Draft Skin Notation Profiles: 
Allyl Alcohol, Formamide, Formic Acid, Phenothiazine, and Picric Acid

AGENCY: Centers for Disease Control and Prevention (CDC), Department of 
Health and Human Services (HHS).

ACTION: Request for comment.

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SUMMARY: The National Institute for Occupational Safety and Health 
(NIOSH) in the Centers for Disease Control and Prevention (CDC), an 
Operating Division of the Department of Health and Human Services 
(HHS), requests public comment on the draft Skin Notation Profiles: 
Allyl alcohol, Formamide, Formic Acid, Phenothiazine, and Picric Acid.

DATES: Electronic or written comments must be received by December 27, 
2024.

ADDRESSES: You may submit comments, identified by docket number CDC-
2024-0085 and docket number NIOSH-153-F, by either of the following 
methods:
    <bullet> Federal eRulemaking Portal: https://www.regulations.gov. 
Follow the instructions for submitting comments.
    <bullet> Mail: National Institute for Occupational Safety and 
Health, NIOSH Docket Office, 1090 Tusculum Avenue, MS C-34, Cincinnati, 
OH 45226-1998.
    Instructions: All information received in response to this notice 
must include the agency name and docket number (CDC-2024-0085; NIOSH-
153-F). All relevant comments, including any personal information 
provided, will be posted without change to https://www.regulations.gov. 
Do not submit comments by email. CDC does not accept comments by email. 
For access to the docket to read background documents or comments 
received, go to https://www.regulations.gov.

FOR FURTHER INFORMATION CONTACT: Naomi Hudson, DrPH, National Institute 
for Occupational Safety and Health, MS C-15, 1090 Tusculum Avenue, 
Cincinnati, OH 45226-1998. Telephone: (513) 533-8388.

SUPPLEMENTARY INFORMATION: NIOSH is requesting public comment on draft 
Skin Notation Profile documents for the chemicals Allyl alcohol, 
Formamide, Formic Acid, Phenothiazine, and Picric Acid. To facilitate 
the review of these documents, NIOSH requests responses to the 
following specific questions for each draft Profile document:
    1. Does this document clearly outline the systemic health hazards 
associated with exposures of the skin to the chemical? If not, what 
specific information is missing from the document?
    2. If the SYS or SYS (FATAL) notations are assigned, are the 
rationale and logic behind the assignment clear? If not assigned, is 
the logic clear why it was not (e.g., insufficient data, no identified 
health hazard)? If not clear, what clarification is suggested?
    3. Does this document clearly outline the direct (localized) health 
hazards associated with exposures of the skin to the chemical? If not, 
what specific information is missing from the document?
    4. If the DIR, DIR (IRR), or DIR (COR) notations are assigned, are 
the rationale and logic behind the assignment clear? If not assigned, 
is the logic clear why it was not (e.g., insufficient data, no 
identified health hazard)? If not clear, what clarification is 
suggested?
    5. Does this document clearly outline the immune-mediated responses 
(allergic response) associated with exposures of the skin to the 
chemical? If not, what specific information is missing from the 
document?
    6. If the SEN notation is assigned, are the rationale and logic 
behind the assignment clear? If not assigned, is the logic clear why it 
was not assigned (e.g., insufficient data, no identified health 
hazard)? If not clear, what clarification is suggested?
    7. If the ID (SK) or SK were assigned, are the rationale and logic 
outlined clearly within the document? If not clear, what clarification 
is suggested?
    8. Are the conclusions supported by the data? If not, what changes 
are suggested?
    9. Are the tables clear and appropriate? If not, what changes are 
suggested?
    10. Are you aware of any scientific data reported in governmental 
publications, databases, peer-reviewed journals, or other sources that 
should be considered within this document? Please include the full 
reference citation for any additional scientific data to be considered.
    11. There have been considerable improvements and advancements in 
dermal absorption studies and modeling since the publication of NIOSH 
Current Intelligence Bulletin 61: A Strategy for Assigning New NIOSH 
Skin Notations [NIOSH 2017]. In response to expert external peer 
reviewers' comments regarding the limitation of the skin to inhalation 
dose (SI) ratio information, the SI ratio was removed from the 
individual skin notation profile documents. Do you have any information 
to support removing or including the SI ratio information in these 
NIOSH documents?
    The draft Skin Notation Profiles were developed to provide the 
scientific rationale behind the development of skin notation 
designations for the following chemicals:

<bullet> Allyl alcohol (CAS: 107-18-6)
<bullet> Formamide (CAS: 75-12-7)
<bullet> Formic acid (CAS: 64-18-6)
<bullet> Picric acid (CAS: 88-89-1)
<bullet> Phenothiazine (CAS: 92-84-2)

    The Skin Notation Profiles provide a detailed summary of the health 
hazards

[[Page 85538]]

of chemical exposure to the skin. The final publication, which will 
address public comments, will be available on the NIOSH website and in 
the NIOSH docket (153-F) and in Regulations.gov (CDC-2024-0085).
    Background: In 2009, NIOSH published Current Intelligence Bulletin 
(CIB) 61: A Strategy for Assigning New NIOSH Skin Notations [NIOSH 
2009]. The CIB presents a strategic framework that is a form of hazard 
identification designed to do the following:

<bullet> Ensure that the assigned skin notations reflect the 
contemporary state of scientific knowledge
<bullet> Provide transparency behind the assignment process
<bullet> Communicate the hazards of chemical exposures of the skin
<bullet> Meet the needs of health professionals, employers, and other 
interested parties in protecting workers from chemical contact with the 
skin.

    This strategy involves the assignment of multiple skin notations 
for distinguishing systemic (SYS), direct (DIR), and sensitizing (SEN) 
effects caused by exposure of skin (SK) to chemicals. Chemicals that 
are highly or extremely toxic and may be potentially lethal or life-
threatening following exposures of the skin are designated with the 
systemic subnotation (FATAL). Potential irritants and corrosive 
chemicals are indicated by the direct effects subnotations (IRR) and 
(COR), respectively. The five draft Skin Notation Profiles available 
for review were developed following the framework in NIOSH CIB 61.

Reference

NIOSH [2009]. Current Intelligence Bulletin 61: A strategy for 
assigning new NIOSH skin notations. Cincinnati, OH: U.S. Department of 
Health and Human Services, Centers for Disease Control and Prevention, 
National Institute for Occupational Safety and Health, DHHS (NIOSH) 
Publication 2009-147, https://www.cdc.gov/niosh/docs/2009-147/.

    Dated: October 23, 2024.
John J. Howard,
Director, National Institute for Occupational Safety and Health, 
Centers for Disease Control and Prevention, Department of Health and 
Human Services.
[FR Doc. 2024-24983 Filed 10-25-24; 8:45 am]
BILLING CODE 4163-18-P