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# OAR Box 1112 Prepped by Ryan Dugan



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# 22 ) ll-C- 1

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£ - A \ UNITE D STATE S ENVIRONMENTA L PROTECTIO N AGENC Y I ^S52 Z * Offic e o f Ai r Qualit

y Plannin g an d Standard s \T** ^ Research Triangl e Park , Nort h Carolin a 2771 1 /} -$ J - Z-

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### jl-C- t ENVIRONMENTA L PROTECTIO N

AGENC Y 

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4
Dr
. Pau l Kotin , Chairma n CENTRAL

. DOCKE T Subcommitte e on Ris k Assessmen t ^ SECTIO N Clea n Ai r Scientifi c Advisor y Committe e ••«•?* » 450 5 Sout h Yosemlt e #33 9 Denver , Colorad o 8023 7 Dea r Dr
. Kotin : Enclose dfo r you r revie w ar e tw o document s (Keeney , 1982 ; Smith , 1982 ) tha t describ e approache s t o th e conduc t o f a healt hris k assessmen t fo r carbo nmonoxid e an d a thir ddocumen t (Whitfield , 1982 ) evaluatin g th e tw o approaches . Als o enclose dar e material s (McCurdy , 1983 ; Wallsten , 1983 ) providin g backgroun dInformatio no nth e developmen t o f a healt h ris k assessmen t fo r lead . Additiona l document s specifi c t o component s o f th e lea dris k assessmen t wil l b e maile dt o th e Subcommitte e b y th e end o f thi s month . W e woul dlik e t o discus s thes e material s wit hth e Subcommitte e a t th e meetin g schedule dfo r Septembe r 14-15 , 1983 . A s yo u hav e discusse dwit hDr . Terry Yosi e 1 nth e preparatio no f th e agenda , w

e woul dlik e t o divid e th e meetin g Int o tw o subjec t areas : a revie w o f th e carbo nmonoxid e (CO ) projec t an d a statu s repor t o

nth e lea dris k assessment . I nth e forme r case , th e C O revie w serve s tw o purposes : firs t t o provid e relevan t backgroun donth e analyti c approache s andencodin g technique s tha t wil l b e applie di nth e lea dproject ; and , second , t o complet e th e wor k o f th e predecesso r advisor y committe e o

n healt hris k assessment . Th e Offic e o f Ai r Qualit y Plannin g an

d Standard s (OAQPS ) ris k assessmen t progra m ha s bee nunde r developmen t fo r severa l years . Durin g thi s time w e hav e consulte dperiodicall y wit hth e forme r Scienc e Advisor y Boar d (SAB ) Subcommitte e onHealt hRis k Assessment . O nth e recommendatio no f thi s Subcommittee , w e examine da numbe r o f analytica l approache s t o healt hris k assessmen t fo r criteri a pollutants . Tw o approache s wer e selecte dfo r applicatio ni na tria l assessmen t o f alternativ e NAAQ S fo r CO . Whil e some problem s exis t 1 nth e underlyin g dat a bas e an d exposur e calculation s use dt o deriv e th e ris k estimate s presente di nth e C O reports , w e believ e thes e d o no t detrac t fro m th e objectiv e o f th e study whic h wa s t o compar e th e tw o developmenta l approache s and asses s th e feasibilit y o f thei r us e 1 nsettin g futur e NAAQS . I t shoul db e note dtha t th e C O study ha s no t bee nuse d1 nth e curren t C O NAAQ S review . Th e fina l report s o neac happroac hand a nevaluatio no f thei r relativ e merit s ar e amon g th e material s enclosed . W e woul dappreciat e th e Subcommittee' s revie w and comment s onth e desig nan d conduc t o f th e C O tria l assessment .P. 3

Inapplyin g ou r ris k assessmen t methodolog y t o th e revie w

o f th e nationa l ambien t ai r qualit y standard s (NAAQS ) fo r lead , w e wil l b e relyin g heavil y

onth e relevan t portion s o f th e lea dcriteri a documen t fo r th e necessar y

Inpu t data . Sinc e thi s documen t ha s no t ye t bee nrelease d fo r externa l review , ou r Initia l presentatio nt o th e Subcommitte e wil l focu s onth e conceptua l basi s fo r andorganizatio no f th e componen t models . W e loo k fowar dt o th e Septembe r meetin g andth e receip t o f you r comment s o

nth e ris k assessmen t progra m an dit s applicatio nt o th e revie w o f th e lea dNAAQS . By copy o f thi s letter , I a m fowardin g th e enclose d material s t o th e member s o f th e Subcommittee . Sincerel y

yours ,

D i recto r Strategie s andA1 r Standard s Divisio n Enclosure s

cc : Subcommitte e Member s T . Yosi eP. 4

Informatio nPackag e fo r Ma i lou t t o CASA C Ris k Assessmen t Subcommitte e

$ Fo r Ma i lou t by 8/24/83 :
T . McCurdy

andH . Richmond . "Descriptio no f th e OAQP S Ris k Program and th e Ongoin g Lea dNAAQ S Ris k Assessmen t Project. " Pape r 83-7- 1 a t APC A Meeting , 1983 . R . L . Keeney , e t al. , Developmen t an dApplicatio no f a Ris k Assessmen t Methodolog y

t o Stud

y Alternativ e Nationa l Ambien t Carbo nMonoxid e Standards . Woodwar dan dClyd e Consultants , 198 2 (Draft) . A . E . Smith , e t al. , Developmen t o f Decisio nAnalysi s Methodolog y fo r Healt hRis k Assessment . SR I International , 198 2 (Draft) . T . S . Wallsten , e t al . Stabilit y andCoherenc e o f Healt hExperts ' Uppe r an dLower , Subjectiv e Probabilitie s abou t Dose-Respons e Functions . Organizationa l Behavio r andHuma nPerformance , 1983 . R . G . Whitfield . "Lette r Report : Evaluatio no f Two Ris k Assessmen t Methodologies. " Argonn e Nationa l Laboratories , Septembe r 16 , 1982 .

Fo r Ma i lou t b

y 8/31/83 :
W . F . Biller . "Descriptio no f Lea dExposur e Mode l (Draft). " Augus t 1983 . W.F . Biller . "Descriptio no f Lea dPhysiologica l Mode l (Draft). " Augus t 1983 . R.G . Whitfield . "Descriptio no f th e Dose-Respons e andRis k Modelin g Effort. " Argonn e Nationa l Laboratories , Augus t 1983 .