UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGT O N , D
. C

. 20460 

## JUN 12 

## 2013

MEMORANDUM OFF I CE OF CHEMICAL SAFETY A N D POLLUTIO N PR EVE N T I O N



### SUBJECT: BEAD Chemical Profile for Registration Review: Metofluthrin (1 09709) FROM:

THRU: David Brassard , Senior Entomologist Biological Analysis Branch Jihad Alsadek , Ph.D. , Economist

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# J-**v~~ /f~**  Science Information and Analysis Branch John Faulkner, Ph.D., Economist Economic Analysis Branch Biological and Economic Analysis Division (7503P) Arnet Jones , Chief 

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# :fo~, Biological Analysis Br £c"h / , Diann S ims , Chief**~~ ..-L** **~** 

### Science Inf ormat ion and Analysis Branch



# .. Timothy Kiely, Chief

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# Q Economic Analysis Branch v v \ 

# D Biological and Economic Analysis D" ision (7503P) TO: Veronica Dutch, Chemical Review Manager Risk Management and Impl ementation Branch 5 Pesticide Reevaluation Division (7508P)


### Product Review Pa
. nel date: March 6, 2012 INTRODUCTION The purpose of this document is to convey usage information and a broad overview of the pest management roles of pesticides that are beginnin g to undergo registration review. The anticipated audience consists of the team of EPA staff currentl y evaluating the registration status of metofluthrin, and eventua lly the general public. This document builds upon the data already provided in the " Usage and Label Use D ata Packages" that are also provided to Registration 

### 1Review teams by B EAD. The document is based on information and data available to BEAD as of March 6, 2012. Metofluthrin is a vap or - active Type I pyrethroid ester insectici d e that i s u sed as a mosquito repellant. Metofluthrin has a high vapor pressure and vaporizes at room temperature without heating. Metofluthrin i s markete d as vapor emanator de vice which clips on to the bel t of the (human) user and as an impregnated paper strip containing metofluthrin for use on patios, campsites, decks , cabanas , and other outdoor areas. USE SITES Agricultural Crops Metofluthrin is not r egistere d for u se on any agricultural crop. Non

- Agricultural Use Sites Metofluthrin is registered for use on human s (belt clip-on emanator device ), domestic dwellings (outdoor), patios , camps ites , decks, cabanas , and other outdoor areas.
COMMON FORMULATIONS AND APPLICATION METHODS Metoflut hrin i s fo rmul ated as an impregnated material. Currently there are two end use product s containing metofluthrin. The first product , Off Clip-On Mos quito Repellent® (aka Norm -1 ®) , is for use on humans as a personal outdoor insect repellent emanator consi s ting of a ho l der containing a replaceable cartridge insert coate d with metofluthrin. The product is ac t ivated by turning on a battery powered fan to release the metofluthrin into the air surro un ding the individual
. The d evice can be wo rn by adults or children and prov ide s up to 12 hours of protection against mos q uitoes. The second product, Deckmate®, is an impregnated paper strip containin g metofluthrin for us e on patios, camp sites , decks , cabanas, and other outdoor areas. The Deckrnate Mosquito Repellent strips claim to repel biting mosquitoes for up to 36 hour s per strip
. USAGE Available usage data from Kline and CalDPR databases did not report usage for this chemical on any non -agri cultural s ite s. BEAD's spot inspection of retail stores (hardware , department, grocery, and drug stores) in Virginia (Annandal e, Alexandria, Arlington, and Springfield) Massachusetts (Chicopee and Billerica) , and M a in e (K ittery and Kenn e bunkport ) revealed that these products are widely marketed in the se areas.

2BIOLOGICAL ASPECTS RELEVANT TO METOFLUTHRIN Metofluthrin product labeling claims that the se products are effective against mosquitoes that may carry West Nile virus, western equine encephalitis, and California viral encephalitis which suggests that this product may be useful in preventing mosquito vectored di sease . There are conflicting reports of metofluthrin efficacy against mosquitoes in the literature. Independent testing of t he Off Clip-on Mosquito Repellent® product re sulted in volunte ers being protected for only two hours , not 1 2 hours as specified on the label (Consumer Reports , 2010). Other skin applied inse ct repellent products tested by Consumer Reports repelled mosquitoes for 7 or more hours. Other researchers found metofluthrin emanators to provide 98 to 97% reductions in mosquito landing/biting rates (Lucas et al, 2005; 2007). Kawada et al (2005) and Rapley et al. (2009) reported t hat metofluthrin impregnated strips were effective against mosquitoes when used indoors. The Registration Division considers Clip-on Mosquito Repellent devices as outdoor spatial repellents/ air column treatments which are subject to a 90% repellency performance standard. Traditional skin applied mosquito repellents , in contrast, must comp letely protect test subjects for the specified period of time. EPAs review of efficacy data submitted from two field trials concluded that metofluthrin reduced the incidence of mosquito bites by more than 90% over a 12 hour use period (Suarez, 2007).
INFORMATION THAT MAY BE USEFUL FOR BEAD 'S FUTURE WORK ON METOFLUTHRIN Obtaining additional information on the following items would improve future BEAD assessmen ts of the importance of Metofluthrin and may be required as part of the registration review of this pesticide. BEAD lacks information regarding the usage of the two metofluthrin products (e.g. number of units sold annually)
. This information would be helpful in assessing what proportion oftlhe pop ulation uses these products and how frequently these products are applied to users (e.g. t ypical number of applications pre year).

REFERENCES
CalDPR. 2007. California Department of Pe sticide Regulation Public Report 2007-6: Active Ingredient: Metofluthrin. http ://www.cdpr.ca.gov/docs/registration/ais/pub li creports/ 5943.pdf Consumer Reports. 2010. Best insect repellents: Consumer Report s Test of Mosquito Repellents. http: //www.consumerreports.o r g/healthlhealthy

- li v ing/beauty-personal

care /insect -repe llen t/ov erview /index.htm



### 3Kawada, H. et al. 2005
. Field Evaluation of Spa t ial Repellency Of Metofluthrin I mpregnated P lastic Strip s Against Mosquitoes in Hai Phong City , V ietnam
. Am. J. Trop. Med
. Hyg. , 73(2), 2005 , pp. 350-353 http: //www.ajtmh.org/ content/73 / 2/ 350.full.pdf + html Lucas, 

### J.R. et al. 200 7. U. S. l aboratory and field trials o f metofluthrin (S umi One) emanators for red ucing mosquito biting outdoors. JAm Mosq Control Assoc. 2007 Mar ; 23(1):47

- 54. http: //www.ncbi.nlrn.nih.gov/pubmed/17536367 L ucas , 

### J.R. et al, 2 005. Field Ef ficacy of Metofluthrin

- A New Mosquito Rep e llent. Proceedings of the Fifth International Conferen ce on Urban P ests. http: //www.icup.org.uk/reports%5CICUP047.pdf Rapl ey, L.P. et al. 2009. The Ef fects of Sustained Rel ease Metofluthrin on the Biting, Move men t , and M ortali ty of Aedes aegyp ti in a Domestic Setting. Am. J
. Trop. Me d
. Hyg. , 81(1) , 2009 , pp. 94-99. http: //www.ajtmh.org/content/81 / l / 94.full.pdf + htrnl Suarez, M. 2007. Efficacy Review of NORM I Metofluthrin Ins ect Repellent (MRID 46402003 ). U.S. EPA. 2006
. P estic ide Fact Sheet for Metofluthrin. http: //www.epa.gov / opprd001 /factsheets /metofluthrin.pdf



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