EX-10.43



 Exhibit 10.43 

CONFIDENTIAL TREATMENT REQUESTED 

THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES AND EXCHANGE COMMISSION (THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE
SECURITIES ACT OF 1933, AS AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT AND FILED SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS
EXHIBIT WITH “*****”. 
 THIRD AMENDMENT TO THE LICENSE AGREEMENT 

UC Control No. 2011-04-0059 
 THIS THIRD
AMENDMENT (the “Third Amendment”), dated August 30, 2012 (the “Effective Date”), is made by and between THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (“The Regents”), a California corporation
having its statewide administrative offices at 1111 Franklin Street, 12th Floor, Oakland, California 94607-5200, acting through the offices of The University of California, Los Angeles located
at 11000 Kinross Avenue, Suite #200, Los Angeles, CA 90095-1406 and NEUROSIGMA, INC. (“Licensee”) having a principal place of business at 10960 Wilshire Boulevard., Suite 1230, Los Angeles, CA, 90024 and amends the
license agreement with Licensee, dated July 26, 20 l 0 with UC Agreement Control Number 2011-04-0059, the First Amendment dated January 9, 2011, and the Second Amendment dated July 29, 2011 (the “License Agreement”),
in accordance with the terms and conditions of this Third Amendment. 
 RECITALS 

WHEREAS, the parties desire to add UCLA Case No. 2011-311 (“*****”) to the License Agreement; 

NOW THEREFORE, in consideration of the foregoing premise s and the mutual promises, covenants, and agreements hereinafter set forth,
all parties to this Third Amendment mutually agree to amend the License Agreement as follows: 
  

	1.	AMEND the first WHEREAS clause of the RECITALS of the License Agreement by: 

  

	 	a)	adding the following invention to those listed: 

  

	 	“8)	“*****”  

  

	 	    	(UCLA Case No. 2011-311);” 

  

	 	b)	adding the following inventors to the those listed: 

  

	 	“*****”	and “*****” 

  

	2.	ADD the following patent rights to APPENDIX A (REGENTS’ PATENT RIGHTS) of the License Agreement: 

  

	 	“8	UCLA CASE NO. 2011-311: “*****” 


Provisional Patent Application No. 61/620,879 ***** (UCLA Case No. 2011-311-1) *****” 

All other terms and conditions of the License Agreement remain the same. 

  
 FIN XE 3rd AMNT (Neurosigma – 2011-04-0059) 08 30 12 
 THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES
AND EXCHANGE COMMISSION (THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT,
AND HAVE BEEN FILED SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT WITH “*****”. 
  

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 CONFIDENTIAL TREATMENT REQUESTED 

 

 This Third Amendment may be executed in two or more counterparts, each of which shall be
deemed an original but all of which together shall constitute one and the same instrument. Facsimile, Portable Document Format (PDF) or photocopied signatures of the Parties will have the same legal validity as original signatures. 

IN WITNESS WHEREOF, the parties have executed this Third Amendment by their duly authorized representatives for good and valuable
consideration. 
  

									
	NEUROSIGMA, INC.	 		 	THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
					
	By:	 	 /s/ Leon Ekchian
	 		 	By:	 	 /s/ Emily Loughran

	Name:	 	Leon Ekchian	 		 	Name:	 	Emily Loughran
	Title:	 	President & CEO	 		 	Title:	 	Director of Licensing
	Date:	 	August 30, 2012	 		 	Date:	 	August 30, 2012


  
 FIN XE 3rd AMNT (Neurosigma – 2011-04-0059) 08 30 12 
 THE COMPANY HAS REQUESTED AN ORDER FROM THE SECURITIES
AND EXCHANGE COMMISSION (THE “COMMISSION”) PURSUANT TO RULE 406 UNDER THE SECURITIES ACT OF 1933, AS AMENDED, GRANTING CONFIDENTIAL TREATMENT TO SELECTED PORTIONS. ACCORDINGLY, THE CONFIDENTIAL PORTIONS HAVE BEEN OMITTED FROM THIS EXHIBIT,
AND HAVE BEEN FILED SEPARATELY WITH THE COMMISSION. OMITTED PORTIONS ARE INDICATED IN THIS EXHIBIT WITH “*****”. 
  

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