EX-4.27



 Exhibit 4.27 

CONFIDENTIAL 
 Tier 4

 THIS NOTE HAS NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY STATE SECURITIES LAWS. IT MAY NOT BE SOLD, OFFERED FOR
SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION STATEMENT AS TO THE SECURITIES UNDER SAID ACT OR ANY APPLICABLE STATE SECURITIES LAWS, OR AN OPINION OF COUNSEL SATISFACTORY TO THE CORPORATION THAT SUCH REGISTRATION IS NOT
REQUIRED. 
 NEUROSIGMA, INC. 

PROMISSORY NOTE 

August 4, 2014 
  

					
	 $699,986.56
	  	 	Los Angeles, California	  

 FOR VALUE RECEIVED, NeuroSigma, Inc., a Delaware corporation (the “Company”), promises
to pay to Lodwrick M. Cook (the “Investor”), or its registered assigns, in lawful money of the United States of America the principal sum of $699,986.56, or such lesser amount as shall equal the outstanding principal amount
hereof, together with simple interest from the date of this Promissory Note (the “Note”) on the original principal balance at a rate equal to twelve percent (12%) per annum until June 30, 2015 (the
“Interest Amount”). Principal and the Interest Amount shall be due and payable in full on July 1, 2015. This Note is one of the “Notes” issued pursuant to the Note and Warrant Purchase Agreement
dated as of November 13, 2013 (the “Note Purchase Agreement”). Capitalized terms not otherwise defined herein shall have the meaning set forth in the Note Purchase Agreement. 

The following is a statement of the rights of the Investor and the conditions to which this Note is subject, and to which the Investor, by the
acceptance of this Note, agrees: 
 1. Prepayment. Notwithstanding the foregoing, the Company may, in its sole
discretion, prepay the full outstanding principal balance hereunder, together with the full Interest Amount, at any time prior to July 1, 2015. 

2. Waiver and Amendment. Any provision of this Note may be amended, waived or modified upon the written consent of
Company and a Majority in Interest. Notwithstanding the foregoing, in the event an amendment, waiver, or modification of this Note adversely affects the rights of the Investor in a manner different than the other Investors other than by virtue of
the amount of principal and interest then outstanding owed to such Investors, then the written consent of the Investor shall also be required to enforce such amendment, waiver or modification. 

  
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 CONFIDENTIAL 

Tier 4 
 3.
Notices. All notices, requests, demands, consents, instructions or other communications required or permitted hereunder shall in writing and faxed, mailed or delivered to each party at the respective addresses of the parties as
set forth in the Note Purchase Agreement, or at such other address or facsimile number as Company shall have furnished to the Investor in writing. All such notices and communications shall be effective (a) when sent by Federal Express or other
overnight service of recognized standing, on the business day following the deposit with such service; (b) when mailed, by registered or certified mail, first class postage prepaid and addressed as aforesaid through the United States Postal
Service, upon receipt; (c) when delivered by hand, upon delivery; and (d) when faxed, upon confirmation of receipt. 
 4.
Usury. In the event any interest is paid on this Note is deemed to be in excess of the then legal maximum rate, then that portion of the interest payment representing an amount in excess of the then legal maximum rate shall be
deemed a payment of principal and applied against the principal of this Note. 
 5. Waivers. Company hereby waives
notice of default, presentment or demand for payment, protest or notice of nonpayment or dishonor and all other notices or demands relative to this instrument. 

6. Transfer of this Note. This Note and all rights hereunder may only be transferred, in whole or in part, to an
affiliate of the holder hereof; provided, however, that (x) such affiliate shall have agreed with all parties hereto, in a written instrument reasonably satisfactory to the Company, (1) providing that such affiliate shall be
bound by the terms of this Note and (2) that contains the representations and warranties set forth in Section 3 of the Note Purchase Agreement, and (y) as a condition to such transfer, the holder hereof shall surrender this Note to
the Company to permit the Company to deliver a new Note in such affiliate’s name. Except as set forth in Section 6, this Note may not be transferred without the prior written consent of the Company in its sole discretion. All
transfers of this Note must also be made in accordance with the Securities Act, and applicable state securities laws. Any attempted transfer of this Note in violation of this Section 6 shall be null and void ab initio. Upon
surrender of this Note to the Company, together with instructions by the applicable holder hereof that all or a portion of this Note be assigned, the Company shall execute and deliver a new Note in the name of the affiliate or affiliates named in
such instrument of assignment and, if the applicable holder’s entire interest is not being assigned, in the name of the prior holder, and this Note shall promptly be canceled. Each such new Note shall bear any legend as to the applicable
restrictions on transferability in order to ensure compliance with such laws, including, without limitation, the legend set forth on the face of this Note. Prior to presentation of this Note to the Company for transfer, the Company shall treat the
registered holder hereof as the owner and holder of this Note for the purpose of receiving all payments of principal and interest hereon and for all other purposes whatsoever, whether or not this Note shall be overdue and the Company shall not be
affected by notice to the contrary. 

  
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 CONFIDENTIAL 

Tier 4 
 7.
Governing Law. This Note and all actions arising out of or in connection with this Note shall be governed by and construed in accordance with the laws of the State of California, without regard to the conflicts of law provisions
of the State of California, or of any other state. 
 8. Counterparts. This Note may be executed in one or more
counterparts, each of which will be deemed an original, but all of which together will constitute one and the same agreement. Facsimile copies of signed signature pages will be deemed binding originals. 

[Signature Pages Follow] 

  
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 CONFIDENTIAL 

Tier 4 
 IN WITNESS WHEREOF,
the Company has caused this Note to be issued as of the date first written above. 
  

			
	NEUROSIGMA, INC.
	a Delaware corporation
		
	By:	 	 /s/ Leon Ekchian

	Name:	 	 Leon Ekchian

	Title:	 	 President and CEO



 [Signature Pages Continue on the Following Page] 

[Signature Page to the Promissory Note] 







 CONFIDENTIAL 

Tier 4 
 ACKNOWLEDGED AND AGREED:

 FOR INVESTORS THAT ARE INDIVIDUALS: 
  

									
	Date:	 	 August 19, 2014
	 		 	Signature:
		 		 		 	 /s/ Lodwrick M. Cook

			
		 		 	Name (please print):
		 		 	 Lodwrick M. Cook

					
		 		 		 	Address:	 	 13849 Weddington Street

		 		 	
                 Sherman Oaks, CA
91401


 FOR INVESTORS THAT ARE TRUSTS: 
  

									
	Date:	 	  
	 		 	Name of Trust:	 	  

				
		 		 		 	  

				
		 		 		 	  



									
				
		 		 	Signature of Trustee	 	  



									
				
		 		 	If applicable:	 	
				
		 		 	Signature of Co-Trustee:	 	  



FOR INVESTORS THAT ARE CORPORATIONS, LIMITED LIABILITY COMPANIES OR PARTNERSHIPS: 

 

									
	Date:	 	  
	 		 	Name of Entity:	 	  

				
		 		 		 	  



									
					
		 		 		 	Signature:	 	  



									
					
		 		 		 	Title of Signatory:	 	  



[Signature Page to the Promissory Note] 







 CONFIDENTIAL 

Tier 4 
 THIS WARRANT AND THE SECURITIES
ISSUABLE UPON THE EXERCISE HEREOF HAVE NOT BEEN REGISTERED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, OR ANY STATE SECURITIES LAWS. THEY MAY NOT BE SOLD, OFFERED FOR SALE, PLEDGED OR HYPOTHECATED IN THE ABSENCE OF AN EFFECTIVE REGISTRATION
STATEMENT AS TO THE SECURITIES UNDER SAID ACT OR ANY APPLICABLE STATE SECURITIES LAWS, OR AN OPINION OF COUNSEL SATISFACTORY TO THE CORPORATION THAT SUCH REGISTRATION IS NOT REQUIRED. 

THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT ARE SUBJECT TO A LOCKUP PERIOD FOLLOWING THE EFFECTIVE DATE OF A REGISTRATION STATEMENT OF THE
COMPANY FILED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AS SET FORTH IN AN AGREEMENT BETWEEN THE ISSUER AND THE ORIGINAL HOLDER OF THIS WARRANT, A COPY OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF THE ISSUER. SUCH LOCKUP PERIOD IS BINDING
ON TRANSFEREES OF THIS WARRANT OR THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT. 
 NEUROSIGMA, INC. 

WARRANT TO PURCHASE SHARES 

August 4, 2014 
 Void
after 
 August 4, 2019 

This Warrant is issued to Lodwrick M. Cook by NeuroSigma, Inc., a Delaware corporation, (the “Company”), pursuant to
the terms of that certain Note and Warrant Purchase Agreement dated November 13, 2013 (as amended, modified or supplemented, the “Note Purchase Agreement”) in connection with the Company’s issuance to the initial
holder of this Warrant of a Promissory Note (the “Note”). 
 1. Purchase of Shares. Subject to
the terms and conditions hereinafter set forth and set forth in the Note Purchase Agreement, the holder of this Warrant is entitled, upon surrender of this Warrant at the principal office of the Company (or at such other place as the Company shall
notify the holder hereof in writing), to purchase from the Company up to the number of fully paid and nonassessable shares of the Company’s Common Stock (as more fully described below, the “Shares”), that equals the
quotient obtained by dividing (a) the Warrant Coverage Amount (defined below) by (b) the Exercise Price (defined below). 

  
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 CONFIDENTIAL 

Tier 4 
 2.
Definitions. 
 (a) Exercise Price. The exercise price for the Shares shall be $8.33 per share.
Such price shall be subject to adjustment pursuant to Section 6 hereof (such price, as adjusted from time to time, is herein referred to as the “Exercise Price”). 

(b) Exercise Period. This Warrant shall be exercisable, in whole or in part, during the term commencing on the date hereof and ending
on the close of business on the date that is the five year anniversary of the date hereof. 
 (c) Warrant Coverage Amount. The term
“Warrant Coverage Amount” means that amount which equals 25% of the original principal amount of the Note. 
 (d)
Shares. The term “Shares” means the Company’s Common Stock subject to this Warrant. The number of Shares for which this Warrant is exercisable is subject to adjustment pursuant to Sections 6 and 7
hereof. 
 3. Method of Exercise. While this Warrant remains outstanding and exercisable in accordance with
Section 2 above, the holder may exercise, in whole or in part, the purchase rights evidenced hereby. Such exercise shall be effected by: 

(a) the surrender of the Warrant, together with a notice of exercise to the Secretary of the Company at its principal offices; and 

(b) the payment to the Company of an amount equal to the aggregate Exercise Price for the number of Shares being purchased. 

4. Net Exercise. In lieu of cash exercising this Warrant, the holder of this Warrant may elect to receive shares equal to
the value of this Warrant (or the portion thereof being canceled) by surrender of this Warrant at the principal office of the Company together with notice of such election, in which event the Company shall issue to the holder hereof a number of
Shares computed using the following formula: 
  

			
	 X =
	  	Y (A - B)
	  	A

 Where 

X = The number of Shares to be issued to the holder of this Warrant. 

Y = The number of Shares purchasable under this Warrant. 

A = The Fair Market Value (defined below) of one Share. 

B = The Exercise Price (as adjusted to the date of such calculations). 

  
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 CONFIDENTIAL 

Tier 4 
 For purposes of
this Section 4, the “Fair Market Value” of a Share shall be the price per Share that the Company could obtain from a willing buyer for the Shares sold by the Company from authorized but unissued Shares, as such prices shall be
determined in good faith by the Company’s Board of Directors; provided, that, if the Warrant is being exercised upon the closing of the issuance and sale of shares of Common Stock of the Company in the Company’s first underwritten
public offering pursuant to an effective registration statement under the Securities Act of 1933, as amended, the value will be the initial “Price to Public” of one such Share specified in the final prospectus with respect to such offering

 5. Certificates for Shares. Upon the exercise of the purchase rights evidenced by this Warrant, one or more
certificates for the number of Shares so purchased (bearing such legends as are required by any subscription agreement, the Note Purchase Agreement, this Warrant, and applicable state and federal securities laws in the opinion of counsel to the
Company) shall be issued as soon as practicable thereafter, and in any event within thirty (30) days of the delivery of a subscription notice. 

6. Adjustment of Exercise Price and Number of Shares. The number of and kind of securities purchasable upon exercise of
this Warrant and the Exercise Price shall be subject to adjustment from time to time as follows: 
 (a) Subdivisions, Combinations and
Other Issuances. If the Company shall at any time prior to the expiration of this Warrant subdivide its Common Stock, by split-up or otherwise, or combine its Common Stock, or issue additional shares of its Common Stock as a dividend, the number
of Shares issuable on the exercise of this Warrant shall forthwith be proportionately increased in the case of a subdivision or stock dividend, or proportionately decreased in the case of a combination. Appropriate adjustments shall also be made to
the purchase price payable per share, but the aggregate purchase price payable for the total number of Shares purchasable under this Warrant (as adjusted) shall remain the same. Any adjustment under this Section 6(a) shall become
effective at the close of business on the date the subdivision or combination becomes effective, or as of the record date of such dividend, or in the event that no record date is fixed, upon the making of such dividend. 

(b) Reclassification, Reorganization and Consolidation. In case of any reclassification, capital reorganization, or change in the
Common Stock of the Company (other than as a result of a subdivision, combination, or stock dividend provided for in Section 6(a) above), then, as a condition of such reclassification, reorganization, or change, lawful provision shall be
made, and duly executed documents evidencing the same from the Company or its successor shall be delivered to the holder of this Warrant, so that the holder of this Warrant shall have the right at any time prior to the expiration of this Warrant to
purchase, at a total price equal to that payable upon the exercise of this Warrant, the kind and amount of shares of stock and other securities and property receivable in connection with such reclassification, reorganization, or


  
 3 








 
CONFIDENTIAL 
 Tier 4 

change by a holder of the same number of Shares as were purchasable by the holder of this Warrant immediately prior to such reclassification, reorganization,
or change. In any such case appropriate provisions shall be made with respect to the rights and interest of the holder of this Warrant so that the provisions hereof shall thereafter be applicable with respect to any shares of stock or other
securities and property deliverable upon exercise hereof, and appropriate adjustments shall be made to the purchase price per share payable hereunder, provided the aggregate purchase price shall remain the same. 

(c) Notice of Adjustment. When any adjustment is required to be made in the number or kind of shares purchasable upon exercise of the
Warrant, or in the Exercise Price, the Company shall promptly notify the holder of such event and of the number of Shares or other securities or property thereafter purchasable upon exercise of this Warrant. 

7. No Fractional Shares or Scrip. No fractional shares or scrip representing fractional shares shall be issued upon the
exercise of this Warrant, but in lieu of such fractional shares the Company shall make a cash payment therefor on the basis of the Exercise Price then in effect. 

8. No Stockholder Rights. Prior to exercise of this Warrant, the holder shall not be entitled to any rights of a
stockholder with respect to the Shares, including (without limitation) the right to vote such Shares, receive dividends or other distributions thereon, exercise preemptive rights or be notified of stockholder meetings, and such holder shall not be
entitled to any notice or other communication concerning the business or affairs of the Company. 
 9. Amendments and
Waivers. Any term of this Warrant may be amended and the observance of any term of this Warrant may be waived (either generally or in a particular instance and either retroactively or prospectively), with the written consent of the
Company and the holders of a majority of securities issued or issuable upon exercise of the Warrants issued pursuant to the Note Purchase Agreement. Notwithstanding the foregoing, in the event an amendment or waiver of this Agreement adversely
affects the rights of the holder in a manner different than the other holders other than by virtue of the number of shares exercisable under the Warrants, then the written consent of the holder shall also be required to enforce such amendment or
waiver. 
 10. Transfer. This Warrant, the shares of Common Stock issued upon exercise of this Warrant and all other
rights hereunder may only be transferred, in whole or in part, to an affiliate of the holder of this Warrant, without charge (except for transfer taxes); provided, however, that (x) such affiliate shall have agreed with all
parties hereto, in a written instrument reasonably satisfactory to the Company, that (1) provides that such affiliate shall be bound by the terms of this Warrant, and (2) contains the representations and warranties set forth in
Section 3 of the Note Purchase Agreement, and (y) as a condition to such transfer, such affiliate shall surrender this Warrant to the Company to permit the Company to deliver a new Warrant in such affiliate’s name. Except as set forth
in Section 10, this Warrant may not be transferred without the prior written consent of the Company in its sole discretion. All transfers of this Warrant, or any shares of 

  
 4 








 
CONFIDENTIAL 
 Tier 4 

Common Stock issued upon exercise of this Warrant, must also be made in accordance with the Securities Act, and applicable state securities laws. Any
attempted transfer of this Warrant, or any shares of Common Stock issued upon exercise of this Warrant, in violation of this Section 10 shall be null and void ab initio. Upon surrender of this Warrant to the Company, together with
instructions by the applicable holder hereof that all or a portion of this Warrant be assigned, the Company shall execute and deliver a new Warrant in the name of the assignee or assignees named in such instrument of assignment and, if the
applicable holder’s entire interest is not being assigned, in the name of the transferring holder, and this Warrant shall promptly be canceled. Each certificate representing the shares of Common Stock issued upon exercise of this Warrant
transferred in accordance with this Section 10 shall bear any legend as to the applicable restrictions on transferability in order to ensure compliance with such laws, including, without limitation, the legends set forth in Sections
12 and 13. 
 11. Governing Law. This Warrant shall be governed by and construed in accordance with the laws
of the State of California, without regard to the conflicts of law provisions of the State of California, or of any other state. 
 12.
Lock-Up Agreement. The holder of this Warrant agrees, in connection with the Company’s initial public offering of the Company’s securities, upon request of the Company or the underwriters managing any underwritten
offering of the Company’s securities, not to sell, make any short sale of, loan, grant any option for the purchase of, or otherwise dispose of any of the Company’s securities (other than those included in the registration) without the
prior written consent of the Company or such underwriters, as the case may be, for such period of time (not to exceed one hundred eighty (180) days) from the effective date of such registration as may be requested by the underwriters;
provided, however, that such 180 day period may be extended to the extent necessary to permit any managing underwriter to comply with NASD Rule 2711(f)(4) or any successor rule thereto. The holder of this Warrant acknowledges that the
Company will cause to be placed on any securities issued directly or indirectly upon exercise this Warrant the following legend: 
 “THE
SECURITIES REPRESENTED BY THIS CERTIFICATE ARE SUBJECT TO A LOCKUP PERIOD FOLLOWING THE EFFECTIVE DATE OF A REGISTRATION STATEMENT OF THE COMPANY FILED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AS SET FORTH IN AN AGREEMENT BETWEEN THE ISSUER AND
THE ORIGINAL HOLDER OF THESE SECURITIES, A COPY OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF THE ISSUER. SUCH LOCKUP PERIOD IS BINDING ON TRANSFEREES OF THESE SHARES.” 

  
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 CONFIDENTIAL 

Tier 4 
 13. Other
Restrictive Legends. The holder of this Warrant acknowledges that the Company will cause to be placed on any securities issued directly or indirectly upon exercise this Warrant the following legend: 

“THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT ARE SUBJECT TO A LOCKUP PERIOD FOLLOWING THE EFFECTIVE DATE OF A REGISTRATION
STATEMENT OF THE COMPANY FILED UNDER THE SECURITIES ACT OF 1933, AS AMENDED, AS SET FORTH IN AN AGREEMENT BETWEEN THE ISSUER AND THE ORIGINAL HOLDER OF THIS WARRANT, A COPY OF WHICH MAY BE OBTAINED AT THE PRINCIPAL OFFICE OF THE ISSUER. SUCH LOCKUP
PERIOD IS BINDING ON TRANSFEREES OF THIS WARRANT OR THE SECURITIES ISSUABLE UPON EXERCISE OF THIS WARRANT.” 
 14.
Counterparts. This Warrant may be executed in one or more counterparts, each of which will be deemed an original, but all of which together will constitute one and the same agreement. Facsimile copies of signed signature pages
will be deemed binding originals. 
 [Signature Pages Follow] 

  
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 CONFIDENTIAL 

Tier 4 
 IN WITNESS WHEREOF,
Company has caused this Warrant to be issued as of the date first written above. 
  

			
	NEUROSIGMA, INC.
	a Delaware corporation
		
	By:	 	  

	Name:	 	  

	Title:	 	  



 [Signatures Pages Continue on the Following Page] 

  
 [Signature Page to the
Warrant] 








 ACKNOWLEDGED AND AGREED: 

FOR INVESTORS THAT ARE INDIVIDUALS: 
  

									
	Date:	 	  
	 		 	Signature:	 	
		 		 		 	  

				
		 		 		 	Name (please print):
		 		 		 	  


 FOR INVESTORS THAT ARE TRUSTS: 
  

									
	Date:	 	  
	 		 	Name of Trust:	 	  

				
		 		 		 	  

				
		 		 		 	  



									
					
		 		 		 	Signature of Trustee	 	  

				
		 		 		 	If applicable:


									
					
		 		 		 	Signature of Co-Trustee:	 	  


 FOR INVESTORS THAT ARE CORPORATIONS, LIMITED LIABILITY COMPANIES OR PARTNERSHIPS: 

 

									
	Date:	 	  
	 		 	Name of Entity:	 	  

				
		 		 		 	  



									
					
		 		 		 	Signature:	 	  



									
					
		 		 		 	Title of Signatory:	 	  



  
 [Signature Page to the
Warrant]