### UNITED STA **TES ENVIRONMENTA L PROTECTION A** **GENCY WA** **SHINGTON, D.C. 20460 OFFICE OF**  **CHEMICAL SAFETY AND POLLUTION PREVENTION** 



### MEMORANDUM **Date :**  December 3, 2013 **SUBJECT: Chlorantraniliprole**  Chronic Dietary (Food and Drinking Water) Exposure and Risk Assessment for the Section (3) Registration Action s on Green Onion Subgroup 3 - 07b, and Peanut; and for the Requests to Update the Crop Groups of Stone Fruit, Tree Nut, and Spices; and to Shorten the Pre - Harvest Intervals for Papaya, Passionfruit, and May haw. **PC Code:** 090100 **DP Barcode s**  **:** D 416093 **Decision No s**  **.:** 476038, 477960,477964, 477967, 477972, 477952, 477965, 477970, 477957, 477963, 477954, 477966, 477971 **Registration No s**  **. :**  352 - 729, 352 - 728, 352 - 730 **Petition No s**  **.:** 3E8170 , 3F8158 **Regulatory Action:** Section 3 **Risk A**  **ss essment Type:**  Dietary **Case No.:** N/A **T XR**  **No.:** N/A **CAS No.:** 500008 - 45 - 7 **MRID No.:** N/A **40 CFR:** §180. 628 **FROM:** Kristin Rury , Biologist

Risk Assessment Branch III Health Effects Division (7509P) **THROUGH:** William Cutchin , Chemist

Id eliz Encarnacion , Chemist Dietary Exposure Science Advisory Council (DESAC) And Christine Olinger , Chief Risk Assessment Branch III Health Effects Division **TO:** Kristin Rury , Risk Assessor

Risk Assessment Branch III Health Effects Division (7509P)Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

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### And Laura Nollen, Risk Manager Risk Integration Minor Use and Emergency Response Branch Division (7505P) And Jennifer Urbanski Insecticide/Rodenticide Branch (IRB) Registration Division (7505P) **Executive Summary** A c hronic aggregate dietary food and drinking water exposure and risk assessment w as conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database (DEEM - FCID) Version 3.16 , which uses food consumption data collected from 2003 - 2008 from the U.S. Department of Agriculture’s (USDA’s) National Health and Nutrition Examination Survey, What We Eat in America, (NHANES/WWEIA). The anal ys is was conducted to support a human health risk assessment for (1) the proposed uses on green o nion s ubgroup 3 - 07b, and p eanut; (2) to update the existing s tone f ruit, tree nut, and spices crop groups to correspond with new crop group definitions ; and (3) to s horten the p re - harvest intervals (PHIs) for p apaya, p assionfruit, and m ayhaw. This memo was reviewed by two peer reviewed of the Dietary

Exposure Sci ence Advisory Council (DESAC), per the DESAC Standard Operating Procedure (SOP) 2012.1. Acute Dietary Exposure Assessment : An acute dietary toxicity endpoint was not identified in the toxicity database for chlorantraniliprole; therefore, chlorantraniliprole do es not pose an acute dietary risk and an acute dietary assessment is not required. Chronic Dietary Exposure Assessment : The chronic dietary (food and drinking water) exposure assessment for chlorantraniliprole assumed recommended and/or established tolerance - level residues , 100% crop treated (%CT) , and used DEEM default processing factors. Estimated drinking water concentrations (EDWCs) from the Environmental Fate and Effects Division (EFED) ( 207 ppb) were also included. The results of the chronic anal ys is indicate that chronic dietary (food and drinking water) exposure and risk is not of concern to HED [i.e., <100% chronic population adjusted dose (cPAD)] for the general U.S. population and all population subgroups. The resulting chronic dietary (food and drinking water) risk estimates utilized 2. 3 % of the cPAD for the general U.S. population and 6. 7 % for children 1 - 2 ye ars old , the most highly exposed population subgroup. Cancer Dietary Exposure Assessment : Chlorantraniliprole is classified as “Not Likel y to be Carcinogenic to Humans”; therefore, a cancer dietary risk assessment was not performed.Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

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### I. **Introduction** Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose (i.e., the dose that HED has concluded will result in no unreasonab le adverse health effects). This dose is referred to as the population adjusted dose (PAD). The PAD is equivalent to the point of departure (POD ; no observed adverse effect level, NOAEL ; lowest observed adverse effect level, LOAEL, e.g.) divided by the required uncertainty or safety factors. For acute and non - cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% of the PAD. References that discuss the acute and chronic risk assessments in more detail are available on the EPA/pesticides web site: “Available Information on Assessing Exposure from Pesticides, A User’s Guide,” 21 - JUN - 2000, web link: http://www.epa.gov/fedrgstr/EPA - PEST/2000/July /Day- 12/6061.pdf

; or see SOP 99.6 (20 - AUG 1999). The most recent dietary

risk as sessment for chlorantraniliprole was conducted by Kristin Rury (05/29 /201 3 , D411997 ). **II. Residue Information**  Residues of Concern: Chlorantraniliprole is an insecticide that was developed by DuPont for control of lepidopteran pests. The residue of co ncern for tolerance enforcement in plants, livestock, and water is the parent compound. The residue of concern for risk assessment in plants is the parent compound. The residues of concern for risk assessment in ruminants are the parent compound, IN - HXH4 4 , and IN - K9T00 . T he Risk Assessment team has decided that the residue of concern in poultry commodities for risk assessment will include the parent and the following metabolites: IN - H2H20, IN - K7H29 , IN - F9N04 , and IN - GAZ70. See Attachment 3 for names and structures. Attachment 3 also shows the calculation of the poultry and egg residue levels for dietary

risk assessment. HED also recalculated the dietary burdens for beef and dairy cattle . The resulting residue estimates were below the established to lerances for ruminants ; therefore, tolerance - levels were used in the dietary risk assessment for cattle. Established Tolerances: Permanent tolerances for chlorantraniliprole are currentl y established in/on a wide variety of crops (40 CFR §180.628 ). Re commended Tolerances: E.I. D u Pont de Nemours and Company (DuPont) has submitted an application for the use of chlorantraniliprole on peanuts (PP# 3F8158). Additionally, the Interregional Research Project No. 4 (IR- 4) submitted a petition (PP# 3E8170) to update the existing stone fruit, tree nut, and spices crop group s to correspond with new crop group definitions, and a proposed shorter PHIs for the existing uses on papaya, passionfruit, and may haw. The tolerance recommendations are outlined in Table 1. Residue Data used for Chronic Assessments: HED used tolerance - level residues for the proposed and registered crops and 100% crop treated w as assumed for all commodities included in this assessment ; therefore, this assessment is considered conservative . Where processing dataChlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

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### indicated a reduction (or no increase) in residue upon processing, the residue level of the raw agricultural commodity

( RAC ) was used without reduction, for example mint oil from spearmint. Where processing data indicated an increa se in residue in the processed commodity, a tolerance was established and used, e.g., raisins from grapes. Where adequate processing data did not exist, DEEM default concentration factors w ere used if available. DEEM default concentration factors were us ed for the following: dried apple, apple juice, dried apricot, dried banana, dried beef meat, cherry

juice, field corn s yrup, cranberry juice, grape juice, grapefruit juice, lemon juice, lime juice, dried l ychee, dried (dehydrated) bulb onion, orange juic e, dried peach, dried pear, peanut butter, dried pineapple, pineapple juice, dried plantain, dried plum prune, plum juice, dried potato (flakes, granules), potato flour, tangerine juice, tomato paste, tomato puree, dried tomato, and tomato juice. Table 1 lists all changes to tolerance values and HED recommended tolerances for the prop osed crops used in the dietary assessment. Meat, Milk, Poultry and Eggs : There are no livestock feed items associated with the current petitions. Therefore, the previous livestock dietary intake calculations and resulting tolerance recommendations remain unchanged. **Table 1. Tolerance Summary for Chlorantraniliprole**  **. Comm**  **o dity**  **Established/Proposed Tolerance (ppm)**  **HED -**  **Recommended Tolerance (ppm)**  **Comments**

**( correct commodity definition**  **)** Papaya 2.0 4.0 Passionfruit 2.0 4.0 Peanut, nutmeat 0.06 0.06 Peanut, hay 90 90 Translation from alfalfa hay Onion, green, subgroup 3 - 07B 3.0 3.0 Spice subgroup 19B 14 established/40 proposed 90 Nut, tree, group 14 - 12 0.04 0.02 Crop group conversion. International harmonization. Nut, tree, group 14 0.04 Remove Replaced by crop group 14 - 12 Pistachio 0.04 Remove Replaced by crop group 14 - 12 Fruit, pome, group 11 -

10 1.2 1.2 Crop group conversion Fruit, pome, group 11, except mayhaw 1.2 Remove Replaced by crop group 11 - 10 May haw 0.6 Remove Replaced by crop group 11 - 10 Fruit, stone group 12 - 12, except cherry, Chickasaw plum, and damson plum 4.0 4.0 Crop group conversion Fruit, stone group 12, except cherry, Chickasaw plum, and damson plum 4.0 Remove Replaced by crop group 12 - 12 Crayfish 8.0 0.01 

### I **I I.**  **Percent Crop Treated Information** The chronic dietary

exposure assessment assumed 100% CT for all commodities.Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

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### IV. Drinking Water Data The drinking water residues used in the dietary risk assessment were provided by EFED (C. Koper , 0 7 /24 /2013, D 411577 ; and C. Koper, 09 /23 /201 3 , D 414837 ) and incorporated directl y into this dietary

assessment. Water residues were incorporated in the DEEM - FCID into the food categories “water, direct, all sources” and “water, indirect, all sources.” The EDWC for groundwater from the assessment evaluating the proposed uses is greater than the surface and groundwater estimates from the previous assessment. Thus, the groundwater concentration of 207 ppb was used for this assessment . This value of 207 ppb is the one in ten - year annual mean. EDWCs for the chronic assessments were estimated using two EFED screening models: the Pesticide Root Zone Model ( PRZM ) - Exposure Analy sis Modeling Sy stem ( EXAMS ) and PRZM - Ground Water (GW) . The recommended EDWCs for risk assessment are listed in Table 2 . The model s and their description s are available at the EPA internet site: http://www.epa.gov/oppefed1/models/water/ . **Table 2**  **. Summary of Estimated Surface Water and Groundwater Concentrations**  **(EDWCs) for** 

**Chlora ntraniliprole Used on Cranberries.**  Surface Water Conc., ppb a Groundwater Conc., ppb b Ac ute 55.30 **207** Chronic (non - cancer, 1 in 10 year annual average) 39.87 Chronic (cancer, 30 - year annual average) 39.87 a Pesticide Root Zone Model (PRZM v3.12.2, May 12, 2005) and Exposure Analysis Modeling System (EXAMS v2.98.04.06, April 25, 2005), simulation models, were coupled with the input PE5.pl.shell. The Provisional Cranberry Model was used to assess cranberry. The model does incorporate a degradation component b From the PRZM - GW model. 

### V. **DEEM -**  **FCID Program and Consumption Information** Chlorantraniliprole chronic dietary exposure assessments were conducted using the Dietary Exposure Evaluation Model software with the Food Commodity Intake Database DEEM - FCID, Version 3.16 , which incorporates consumption data from 2003 to 2008 from USDA’s NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 individuals over two non - consecutive survey day s. Foods “as consumed” (e.g., apple pie) are linked to EPA - defined food commodities (e.g. , apples, peeled fruit - cooked; fresh or N/S; baked; or wheat flour - cooked; fresh or N/S, baked) using publicl y available recipe translation files developed jointly

by USDA/ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgrou ps . However , for acute exposure assessment , consumption data are retained as individual consumption events. Based on anal ys is of the 2003 - 2008 WWEIA consumption data, which took into account dietary patterns and survey

respondents, HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, adults 20 - 49, females 13 - 49, and adults 50 - 99 ye ars old.Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

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### For a chronic dietary

exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the average dail y consumption estimate for that food/food form to produce a residue intake estimate. The resulting residue intake estimate for each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expres sed in mg/kg body weight/day and as a percent of the cPAD. This procedure is performed for each population subgroup. **VI. Toxicological Information**  The toxicity

database for chlorantraniliprole is complete. No acute hazard, attributable to a single dose, was identified; therefore, an acute dietary endpoint was not selected for quantitative risk assessment. A composite uncertainty factor of 100 to account for interspecies extrapolation and intraspecies variability

is applied to the NOAEL to derive a cPAD of 1.58 mg/kg/day . The chlorantraniliprole risk assessment team evaluated the quality of the toxicity and exposure data and, based on these data, recommended that the Food Quality Protection Act (FQPA) Safety Factor be reduced to 1 X . Based on the weight of evidence of the available scientific data, and in accordance with EPA’s Final Guidelines for Carcinogen Risk Assessment (March 2005), chlorantraniliprole may be classified as “Not Likely

to Be Carcinogenic to Humans . ” The toxicity

endpoints pertinent for human risk assessment are summarized in Table 3 . **Table 3**  **. Summary of Toxicological Doses and Endpoints for Chlorantraniliprole for Use in Dietary Hum**  **an**

**Health Risk Assessments .**  **Exposure/ Scenario**  **Point of**

**Departure Uncertainty/FQPA** 

**Safety Factors RfD, PAD,**  **Level of Concern for**  **Risk Assessment**  **Study and Toxicological Effects** Ac ute Dietary (All Populations) NA NA NA No acute hazard, attributable to a single dose, was identified; therefore, an acute dietary endpoint was not selected for quantitative risk assessment. Chronic Dietary (All Populations) NOAEL=

158 mg/kg/day UF A= 10x

UF H=10x FQPA SF= 1x Chronic RfD = 1.58 mg/kg/day cPAD = 1.58 mg/kg/day 18 - Month Oral (feeding)/mouse

LOAEL = 935 mg/kg/day based on eosinophilic foci accompanied by hepatocellular hypertrophy and increased liver weight (males only). Cancer (oral, dermal, inhalation) Classification: “Not likely to be Carcinogenic to Humans” based on weight of evidence of data:

no treatment - related tumors were reported in the submitted chronic and oncogenicity studies in rats and mice or in the subchronic studies in mice, dogs and rats; and no mutagenic concern was reported in the genotoxicity studies. Abbreviations: UF = uncertainty factor, UF A = extrapolation from animal to human (interspecies), UF H = potential variation in sensitivity among members of the human population (intraspecies), UF FQPA = FQPA Safety Factor, NOAEL = no - observed adverse - effect level, LOAEL = lowest - observed adverse - effect level, RfD = reference dose (a = acute, c = chronic), PAD = population - adjusted dose, LOC = level of concern.Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

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### VII. **Results/Discussion** As stated above, for chronic assessments, HED is concerned when dietary risk exceeds 100% of the PAD. The DEEM - FCID anal ys es estimate the dietary exposure of the U.S. population and various population subgroups. The results reported in Table 4 are for the general U.S. Population, all infants (<1 year old), children 1 - 2, children 3 - 5, children 6 - 12, youth 13 - 19, females 13 - 49, adults 20 - 49, and adults 50 + years. Results of Chronic Dietary (Food and Drinking Water) Exposure Analysis : The results of the chronic dietary

exposure anal ys is are reported in the summary table below. **Table 4**  **. Summary of Dietary** (Food and Drinking Water) **Exposure and Risk for Chlorantraniliprole.** 

**Population Subgroup Chronic Dietary**  **Dietary Exposure (m**  **g/kg/day) % cPAD** * General U.S. Population 0.036 207 2.3 All Infants (<1 year old) 0.0608 11 3.8 Children 1 - 2 years old* **0. 105269**  **6.7** Children 3 - 5 years old 0. 081499 5.2 Children 6 - 12 years old 0.046 110 2.9 Youth 13 - 19 years old 0.027 234 1.7 Adults 20 - 49 years old 0.03 0559 1.9 Adults 50 - 99 years old 0. 030166 1.9 Females 13 - 49 years old 0. 029398 1.9 *T he subpopulation (s) wi th the highest risk estimate . 

### VIII. **Characterization of Inputs/Outputs** The chlorantraniliprole dietary exposure risk estimates are unrefined and considered conservative since they : (1) assume that 100% of the registered/proposed crops were treated with chlorantraniliprole; (2) use established or recommended tolerance level residues for all crops; (3) use default/conservative processing factors for processed commodities ; and (4) use conservative, modeled drinking water estimates . The tolerances are deriv ed from crop field trials or conservative data translations and default processing factors. At this time, the dietary risks (food and water) of chlorantraniliprole are < 6. 7 % and are not of concern to HED ; therefore no further refinement is required . **IX. Conclusions**  A conservative dietary

(food and drinking water) exposure and risk assessment was performed for chlorantraniliprole. The assumptions incorporated into the assessment included 100% CT, default processing factors, established/proposed tolerance level residues, and conservative EDWCs. The chronic dietary (food and drinking water) exposure estimates are below HED’s level of concern (<100% cPAD) for the general U.S. population and all population subgroups. Chlorantraniliprole dietary (food and drinking water) risk is 2. 3 % of the cPAD for the generalChlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

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### U.S. population and 6. 7 % for children 1 - 2 years old, the most highly exposed population subgroup. HED is confident that the assessment does not underestimate risk to the general U.S. population o r any

population subgroup. **X. List of Attachments**   Chronic Residue Input file  Chronic Results File  Structures of Chlorantraniliprole and Possible MetabolitesChlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

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### Attachment 1: Chronic Food Plus Water Input File Filename: C: \ Documents and Settings \ krury \ My Documents \ My Work Files \ Chlorantraniliprole \ Peanut and Green Onion \ DEEM Files \ CHLORANTRANILIPROLECHRONIC green onion peanut 110813.R08 Chemical: chlorantraniliprole RfD(Chronic): 1.58 mg/kg bw/day NOEL(Chronic): 158 mg/kg bw/day RfD(Acute): 0 mg/kg bw/day NOEL(Acute): 0 mg/kg bw/day Date created/last modified: 11 - 08 - 2013/13:25:05 Program ver. 3.16, 03 - 08 - d Comment: Only a chronic endpoint; there is no acute endpoint

--------------------------------------------------------- -------------------------- EPA Crop Def Res Adj.Factors Comment Code Grp Commodity Name (ppm) #1 #2

---------- ---- ------------------------------- ---------- ------ -- ---- ------- 0101050000 1AB Beet, garden, roots 0.300000 1.000 1.000 0101050001 1AB Beet, garden, roots - babyfood 0.300000 1.000 1.000 0101052000 1A Beet, sugar 0.300000 1.000 1.000 0101052001 1A Beet, sugar - babyfood 0.300000 1.000 1.000 0101053000 1A Beet, sugar, molasses 9.000000 1.000 1.000 0101053001 1A Beet, sugar, molasses - babyfood 9.000000 1.000 1.000 0101067000 1AB Burdock 0.300000 1.000 1.000 0101078000 1AB Carrot 0.300000 1.000 1.000 0101078001 1AB Carrot - babyfood 0.300000 1.000 1.000 0101079000 1AB Carrot, juice 0.300000 1.000 1.000 0101084000 1AB Celeriac 0.300000 1.000 1.000 0101100000 1AB Chicory, roots 0.300000 1.000 1.000 0101168000 1AB Ginseng, dried 0.300000 1.000 1.000 010119000 0 1AB Horseradish 0.300000 1.000 1.000 0101250000 1AB Parsley, turnip rooted 0.300000 1.000 1.000 0101251000 1AB Parsnip 0.300000 1.000 1.000 0101251001 1AB Parsnip - babyfood 0.300000 1.000 1.000 0101314000 1AB Radish, roots 0.300000 1.000 1.000 0101316000 1AB Radish, Oriental, roots 0.300000 1.000 1.000 0101327000 1AB Rutabaga 0.300000 1.000 1.000 0101331000 1AB Salsify, roots 0.300000 1.000 1.000 0101388000 1AB Turnip, roots 0.300000 1.000 1.000 0103015000 1CD Arrowroot, flour 0.300000 1.000 1.000 0103015001 1CD Arrowroot, flour - babyfood 0.300000 1.000 1.000 0103017000 1CD Artichoke, Jerusalem 0.300000 1.000 1.000 0103082000 1CD Cassava 0.300000 1.000 1.000 0103082001 1CD Cassava - b abyfood 0.300000 1.000 1.000 0103139000 1CD Dasheen, corm 0.300000 1.000 1.000 0103166000 1CD Ginger 0.300000 1.000 1.000 0103166001 1CD Ginger - babyfood 0.300000 1.000 1.000 0103167000 1CD Ginger, dried 0.300000 1.000 1.000 0103296000 1C Potato, chips 0.300000 1.000 1.000 0103297000 1C Potato, dry (granules/ flakes) 0.300000 6.500 1.000 0103297001 1C Potato, dry (granules/ flakes) - b 0.300000 6.500 1.000 0103298000 1C Potato, flour 0.300000 6.500 1.000 0103298001 1C Potato, flour - babyfood 0.300000 6.500 1.000 0103299000 1C Potato, tuber, w/peel 0.300000 1.000 1.000 0103299001 1C Potato, tuber, w/peel - babyfood 0.300000 1.000 1.000 0103300000 1C Potato, tuber, w/o peel 0.300000 1.000 1.000 0103300001 1C Potato, tuber, w/o peel - babyfood 0.300000 1.000 1.000 0103366000 1CD Sweet potato 0.300000 1.000 1.000 0103366001 1CD Sweet potato - babyfood 0.300000 1.000 1.000 0103371000 1CD Tanier, corm 0.300000 1.000 1.00 0 0103387000 1CD Turmeric 0.300000 1.000 1.000 0103406000 1CD Yam, true 0.300000 1.000 1.000 0103407000 1CD Yam bean 0.300000 1.000 1.000 0200051000 2 Beet, garden, tops 40.000000 1.000 1.000 0200101000 2 Chicory, tops 40.000000 1.000 1.000 0200140000 2 Dasheen, leaves 40.000000 1.000 1.000 0200315000 2 Radish, tops 40.000000 1.000 1.000 0200317000 2 Radish, Oriental, tops 40.000000 1.000 1.000 0200332000 2 Salsify, tops 40.000000 1.000 1.000Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 10 of 22 0301165000 3A Garlic, b ulb 0.300000 1.000 1.000 0301165001 3A Garlic, bulb - babyfood 0.300000 1.000 1.000 0301237000 3A Onion, bulb 0.300000 1.000 1.000 0301237001 3A Onion, bulb - babyfood 0.300000 1.000 1.000 0301238000 3A Onion, bulb, dried 0.300000 9.000 1.000 0301238001 3A Onion, bulb, dried - babyfood 0.300000 9.000 1.000 0301338000 3A Shallot, bulb 0.300000 1.000 1.000 0302103000 3B Chive, fresh leaves 25.000000 1.000 1.000 0302198000 3B Leek 3.000000 1.000 1.000 0302239000 3B Onion, green 3.000000 1.000 1.000 0302338500 3B Shallot , fresh leaves 3.000000 1.000 1.000 0401005000 4A Amaranth, leafy 13.000000 1.000 1.000 0401018000 4A Arugula 13.000000 1.000 1.000 0401104000 4A Chrysanthemum, garland 13.000000 1.000 1.000 0401133000 4A Cress, garden 13.000000 1.000 1.000 0401134000 4A Cress, upland 13.000000 1.000 1.000 0401138000 4A Dandelion, leaves 13.000000 1.000 1.00 0 0401150000 4A Endive 13.000000 1.000 1.000 0401204000 4A Lettuce, head 13.000000 1.000 1.000 0401205000 4A Lettuce, leaf 13.000000 1.000 1.000 0401248000 4A Parsl ey, leaves 13.000000 1.000 1.000 0401313000 4A Radicchio 13.000000 1.000 1.000 0401355000 4A Spinach 13.000000 1.000 1.000 0401355001 4A Spinach - babyfood 13.000000 1.000 1.000 0402076000 4B Cardoon 13.000000 1.000 1.000 0402085000 4B Celery 13.000000 1.000 1.000 0402085001 4B Celery - babyfood 13.000000 1.000 1.000 0402086000 4B Celery, juice 13.000000 1.000 1.000 0402087000 4B Celtuce 13.000000 1.000 1.000 0402152000 4B Fennel, F lorence 13.000000 1.000 1.000 0402322000 4B Rhubarb 13.000000 1.000 1.000 0402367000 4B Swiss chard 13.000000 1.000 1.000 0501061000 5A Broccoli 4.000000 1.000 1.000 0501061001 5A Broccoli - babyfood 4.000000 1.000 1.000 0501062000 5A Broccoli, Chinese 4.000000 1.000 1.000 0501064000 5A Brussels sprouts 4.000000 1.000 1.000 0501069000 5A Cabbage 4.000000 1.000 1.000 0501071000 5A Cabbage, Chinese, napa 4.000000 1.000 1.000 0501072000 5A Cabbage, Chinese, mustard 4.000000 1.000 1.000 0501083000 5A Caulifl ower 4.000000 1.000 1.000 0501196000 5A Kohlrabi 4.000000 1.000 1.000 0502063000 5B Broccoli raab 11.000000 1.000 1.000 0502070000 5B Cabbage, Chinese, bok choy 11.000000 1.000 1.000 0502117000 5B Collards 11.000000 1.000 1.000 0502194000 5B Kale 11.000000 1.000 1.000 0502229000 5B Mustard greens 11.000000 1.000 1.00 0 0502318000 5B Rape greens 11.000000 1.000 1.000 0502389000 5B Turnip, greens 11.000000 1.000 1.000 0600347000 6 Soybean, seed 2.000000 1.000 1.000 0600349000 6 Soybe an, soy milk 2.000000 1.000 1.000 0600349001 6 Soybean, soy milk - babyfood or in 2.000000 1.000 1.000 0600350000 6 Soybean, oil 2.000000 1.000 1.000 0600350001 6 Soybean, oil - babyfood 2.000000 1.000 1.000 0601043000 6A Bean, snap, succulent 2.000000 1.000 1.000 0601043001 6A Bean, snap, succulent - babyfood 2.000000 1.000 1.000 0601257000 6A Pea, edib le podded, succulent 2.000000 1.000 1.000 0601349500 6AB Soybean, vegetable 2.000000 1.000 1.000 0602031000 6B Bean, broad, succulent 2.000000 1.000 1.000 0602033000 6B Bean, cowpea, succulent 2.000000 1.000 1.000 0602037000 6B Bean, lima, succulent 2.000000 1.000 1.000 0602255000 6B Pea, succulent 2.000000 1.000 1.000 0602255001 6B Pea, succulent - babyfood 2.000000 1.000 1.000 0602259000 6B Pea, pigeon, succulent 2.000000 1.000 1.000 0603030000 6C Bean, black, seed 2.000000 1.000 1.000 0603032000 6C Bean, broad, seed 2.000000 1.000 1.000 0603034000 6C Bean, c owpea, seed 2.000000 1.000 1.000 0603035000 6C Bean, great northern, seed 2.000000 1.000 1.000Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 11 of 22 0603036000 6C Bean, kidney, seed 2.000000 1.000 1.000 0603038000 6C Bean, lima, seed 2.000000 1.000 1.000 0603039000 6C Bean, mung, seed 2.000000 1.000 1.000 0603040000 6C Bean, navy, seed 2.000000 1.000 1.000 0603041000 6C Bean, pink, seed 2.000000 1.000 1.00 0 0603042000 6C Bean, pinto, seed 2.000000 1.000 1.000 0603098000 6C Chickpea, seed 2.000000 1.000 1.000 0603098001 6C Chickpea, seed - babyfood 2.000000 1.000 1.000 0603099000 6C Chick pea, flour 2.000000 1.000 1.000 0603182000 6C Guar, seed 2.000000 1.000 1.000 0603182001 6C Guar, seed - babyfood 2.000000 1.000 1.000 0603203000 6C Lentil, seed 2.000000 1.000 1.000 0603256000 6C Pea, dry 2.000000 1.000 1.000 0603256001 6C Pea, dry - babyfood 2.000000 1.000 1.000 0603258000 6C Pea, pigeon, seed 2.000000 1.000 1.000 0603348000 6C Soybean, flour 2.000000 1.000 1.000 0603348001 6C Soybean, flour - babyfood 2.000000 1.000 1.000 0801374000 8A Tomatillo 1.400000 1.000 1.000 0801375000 8A Tomato 1.400000 1.000 1.000 0801375001 8A Tomato - babyfood 1.400000 1.000 1.000 0801376000 8A Tomato, paste 1.400000 5.400 1.000 0801376001 8A Tomato, paste - babyfood 1.400000 5.400 1.000 0801377000 8A Tomato, puree 1.400000 3.300 1.000 0801377001 8A Tomato, puree - babyfood 1.400000 3.300 1.000 0801378000 8A Tomato, dried 1.400000 14.300 1.000 0801378001 8A Tomato, dried - babyfood 1.400000 14.300 1.000 0801379000 8A Tomato, juice 1.400000 1.500 1.000 0801380000 8A Tomato, Tree 1.400000 1.000 1.000 0802148000 8BC Eggplant 1.400000 1.000 1.000 0802234000 8BC Okra 1.400000 1.000 1.000 0802270000 8B Pepper, bell 1.400000 1.000 1.000 0802270001 8B Pepper, bell - babyfood 1.400000 1.000 1.000 0802271000 8B Pepper, bell, dried 1.400000 1.000 1.000 0802271001 8B Pepper, bell, dried - babyfood 1.400000 1.000 1.00 0 0802272000 8BC Pepper, nonbell 1.400000 1.000 1.000 0802272001 8BC Pepper, nonbell - babyfood 1.400000 1.000 1.000 0802273000 8BC Pepper, nonbell, dried 1.400000 1.000 1.000 0901075000 9A Canta loupe 0.500000 1.000 1.000 0901187000 9A Honeydew melon 0.500000 1.000 1.000 0901399000 9A Watermelon 0.500000 1.000 1.000 0901400000 9A Watermelon, juice 0.500000 1.000 1.000 0902021000 9B Balsam pear 0.500000 1.000 1.000 0902088000 9B Chayote, fruit 0.500000 1.000 1.000 0902102000 9B Chinese waxgourd 0.500000 1.000 1.000 0902135000 9B Cucumber 0.500000 1.000 1.000 0902308000 9B Pumpkin 0.500000 1.000 1.000 0902309000 9B Pumpkin, seed 0.500000 1.000 1.000 0902356000 9B Squash, summer 0.500000 1.000 1.000 0902356001 9B Squash, summer - babyfood 0.500000 1.000 1.000 0902357000 9B Squash, winter 0.500000 1.000 1.000 0902357001 9B Squash, winter - babyfood 0.500000 1.000 1.000 1001106000 10A Citron 1.400000 1.000 1.000 1001107000 10A Citrus hybrids 1.400000 1.000 1.000 1001108000 10A Citrus, oil 1.400000 1.000 1.000 1001240000 10A Orange 1.400000 1.000 1.000 1001241000 10A Orange, juice 1.400000 1.800 1.000 1001241001 10A Orange, juice - babyfood 1.400000 1.800 1.000 1001242000 10A Orange, peel 1.400000 1.000 1.000 1001369000 10A Tangerine 1.400000 1.000 1.000 1001370000 10A Tangerine, juice 1.400000 2.300 1.000 1002197000 10B Kumquat 1.400000 1.000 1.000 1002199000 10B Lemon 1.400000 1.000 1.000 1002200000 10B Lemon, juice 1.400000 2.000 1.00 0 1002200001 10B Lemon, juice - babyfood 1.400000 2.000 1.000 1002201000 10B Lemon, peel 1.400000 1.000 1.000 1002206000 10B Lime 1.400000 1.000 1.000 1002207000 10B Lime, juice 1.400000 2.000 1.000Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 12 of 22 1002207001 10B Lime, juice - babyfood 1.400000 2.000 1.000 1003180000 10C Grapefruit 1.400000 1.000 1.000 1003181000 10C Grapefruit, juice 1.400000 2.100 1.000 1003307000 10C Pummelo 1.400000 1.000 1.000 1100007000 11 Apple, fruit with peel 1.200000 1.000 1.000 1100008000 11 Apple, pe eled fruit 1.200000 1.000 1.000 1100008001 11 Apple, peeled fruit - babyfood 1.200000 1.000 1.000 1100009000 11 Apple, dried 1.200000 8.000 1.000 1100009001 11 Apple, dried - babyfood 1.200000 8.000 1.000 1100010000 11 Apple, juice 1.200000 1.300 1.000 1100010001 11 Apple, juice - babyfood 1.200000 1.300 1.000 1100011000 11 Apple, sauce 1.200000 1.000 1.000 1100011001 11 Apple, sauce - babyfood 1.200000 1.000 1.000 1100129000 11 Crabapple 1.200000 1.000 1.000 1100173500 11 Goji berry 1.400000 1.000 1.000 1100210000 11 Loquat 1.200000 1.000 1.000 1100266000 11 Pear 1.200000 1.000 1.000 1100266001 11 Pear - babyfood 1.200000 1.000 1.000 1100267000 11 Pear, dried 1.200000 6.250 1.000 1100268000 11 Pear, juice 1.200000 1.000 1.000 1100268001 11 Pear, juice - babyfood 1.200000 1.000 1.000 1100310000 11 Quince 1.200000 1.000 1.00 0 1201090000 12A Cherry 2.000000 1.000 1.000 1201090001 12A Cherry - babyfood 2.000000 1.000 1.000 1201091000 12A Cherry, juice 2.000000 1.500 1.000 1201091001 12A Cherr y, juice - babyfood 2.000000 1.500 1.000 1202012000 12B Apricot 4.000000 1.000 1.000 1202012001 12B Apricot - babyfood 4.000000 1.000 1.000 1202013000 12B Apricot, dried 4.000000 6.000 1.000 1202014000 12B Apricot, juice 4.000000 1.000 1.000 1202014001 12B Apricot, juice - babyfood 4.000000 1.000 1.000 1202230000 12B Nectarine 4.000000 1.000 1.000 1202260000 12B Peach 4.000000 1.000 1.000 1202260001 12B Peach - babyfood 4.000000 1.000 1.000 1202261000 12B Peach, dr ied 4.000000 7.000 1.000 1202261001 12B Peach, dried - babyfood 4.000000 7.000 1.000 1202262000 12B Peach, juice 4.000000 1.000 1.000 1202262001 12B Peach, juice - babyfood 4.000000 1.000 1.000 1203285000 12C Plum 4.000000 1.000 1.000 1203285001 12C Plum - babyfood 4.000000 1.000 1.000 1203286000 12C Plum, prune, fresh 4.000000 1.000 1.000 1203286001 12C Plum, prune, fresh - babyfood 4.000000 1.000 1.000 1203287000 12C Plum, prune, dried 4.000000 5.000 1.000 1203287001 12C Plum, prune, dried - babyfood 4.000000 5.000 1.000 1203288000 12C Plum, p rune, juice 4.000000 1.400 1.000 1203288001 12C Plum, prune, juice - babyfood 4.000000 1.400 1.000 1301055000 13A Blackberry 1.800000 1.000 1.000 1301056000 13A Blackberry, juice 1.800000 1.000 1.000 1301056001 13A Blackberry, juice - babyfood 1.800000 1.000 1.000 1301058000 13A Boysenberry 1.800000 1.000 1.000 1301208000 13A Loganberry 1.800000 1.000 1.00 0 1301320000 13A Raspberry 1.800000 1.000 1.000 1301320001 13A Raspberry - babyfood 1.800000 1.000 1.000 1301321000 13A Raspberry, juice 1.800000 1.000 1.000 1301321001 13A Raspb erry, juice - babyfood 1.800000 1.000 1.000 1302057000 13B Blueberry 2.500000 1.000 1.000 1302057001 13B Blueberry - babyfood 2.500000 1.000 1.000 1302136000 13B Currant 2.500000 1.000 1.000 1302137000 13B Currant, dried 2.500000 1.000 1.000 1302149000 13B Elderberry 2.500000 1.000 1.000 1302174000 13B Gooseberry 2.500000 1.000 1.000 1302191000 13B Huckleberry 2.500000 1.000 1.000 1303227000 13C Mulberry 2.500000 1.000 1.000 1304175000 13D Grape 2.500000 1.000 1.000 1304176000 13D Grape, juice 2.500000 1.200 1.000 1304176001 13D Grape, juice - babyfood 2.500000 1.200 1.000 1304179000 13D Grape, wine and sherry 2.500000 1.000 1.000Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 13 of 22 1307130000 13G Cranberry 1.000000 1.000 1.000 1307130001 13G Cranberry - babyfood 1.000000 1.000 1.000 1307131000 13G Cranberry, dried 1.000000 1.000 1.000 1307132000 13G Cranberry, juice 1.000000 1.100 1.000 1307132001 13G Cranberry, juice - babyfood 1.000000 1.100 1.000 1307359000 13G Strawberry 1.000000 1.000 1.000 1307359001 13G Strawbe rry - babyfood 1.000000 1.000 1.000 1307360000 13G Strawberry, juice 1.000000 1.000 1.000 1307360001 13G Strawberry, juice - babyfood 1.000000 1.000 1.000 1400003000 14 Almond 0.020000 1.000 1.000 1400003001 14 Almond - babyfood 0.020000 1.000 1.000 1400004000 14 Almond, oil 0.020000 1.000 1.000 1400004001 14 Almond, oil - babyfood 0.020000 1.000 1.00 0 1400059000 14 Brazil nut 0.020000 1.000 1.000 1400068000 14 Butternut 0.020000 1.000 1.000 1400081000 14 Cashew 0.020000 1.000 1.000 1400092000 14 Chest nut 0.020000 1.000 1.000 1400155000 14 Hazelnut 0.020000 1.000 1.000 1400156000 14 Hazelnut, oil 0.020000 1.000 1.000 1400185000 14 Hickory nut 0.020000 1.000 1.000 1400213000 14 Macadamia nut 0.020000 1.000 1.000 1400269000 14 Pecan 0.020000 1.000 1.000 1400278000 14 Pine nut 0.020000 1.000 1.000 1400282000 14 Pistachio 0.020000 1.000 1.000 1400391000 14 Walnut 0.020000 1.000 1.000 1500025000 15 Barley, pearled barley 6.000000 1.000 1.000 1500025001 15 Barley, pearled barley - babyfood 6.000000 1.000 1.000 1500026000 15 Barley, flour 6.000000 1.000 1.000 1500026001 15 Barley, flour - babyfood 6.000000 1.000 1.000 1500027000 15 Barley, bran 6.000000 1.000 1.000 1500065000 15 Buckwheat 6.000000 1.000 1.000 1500066000 15 Buckwheat, flour 6.000000 1.000 1.000 1500120000 15 Corn, f ield, flour 0.040000 1.000 1.000 1500120001 15 Corn, field, flour - babyfood 0.040000 1.000 1.000 1500121000 15 Corn, field, meal 0.040000 1.000 1.000 1500121001 15 Corn, field, meal - babyfood 0.040000 1.000 1.000 1500122000 15 Corn, field, bran 0.040000 1.000 1.000 1500123000 15 Corn, field, starch 0.040000 1.000 1.000 1500123001 15 Corn, field, starch - babyfood 0.040000 1.000 1.00 0 1500124000 15 Corn, field, syrup 0.040000 1.500 1.000 1500124001 15 Corn, field, syrup - babyfood 0.040000 1.500 1.000 1500125000 15 Corn, field, oil 0.040000 1.000 1.000 1500125001 15 Corn, field, oil - babyfood 0.040000 1.000 1.000 1500126000 15 Corn, pop 0.040000 1.000 1.000 1500127000 15 Corn, sweet 0.040000 1.000 1.000 1500127001 15 Corn, sweet - babyfood 0.040000 1.000 1.000 1500226000 15 Millet, grain 6.000000 1.000 1.000 1500231000 15 Oat, bran 6.000000 1.000 1.000 1500232000 15 Oat, flour 6.000000 1.000 1.000 1500232001 15 Oat, flour - babyfood 6.000000 1.000 1.000 1500233000 15 Oat, groats/rolled oats 6.000000 1.000 1.000 1500233001 15 Oat, groa ts/rolled oats - babyfood 6.000000 1.000 1.000 1500323000 15 Rice, white 0.150000 1.000 1.000 1500323001 15 Rice, white - babyfood 0.150000 1.000 1.000 1500324000 15 Rice, brown 0.150000 1.000 1.000 1500324001 15 Rice, brown - babyfood 0.150000 1.000 1.000 1500325000 15 Rice, flour 0.150000 1.000 1.000 1500325001 15 Rice, flour - babyfood 0.150000 1.000 1.000 1500326000 15 Rice, bran 0.150000 1.000 1.000 1500326001 15 Rice, bran - babyfood 0.150000 1.000 1.000 1500328000 15 Rye, grain 6.000000 1.000 1.000 1500329000 15 Rye, fl our 6.000000 1.000 1.000 1500344000 15 Sorghum, grain 6.000000 1.000 1.000 1500345000 15 Sorghum, syrup 6.000000 1.000 1.000 1500381000 15 Triticale, flour 6.000000 1.000 1.000 1500381001 15 Triticale, flour - babyfood 6.000000 1.000 1.000 1500401000 15 Wheat, grain 6.000000 1.000 1.000Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 14 of 22 1500401001 15 Wheat, grain - babyfood 6.000000 1.000 1.00 0 1500402000 15 Wheat, flour 0.160000 1.000 1.000 1500402001 15 Wheat, flour - babyfood 0.160000 1.000 1.000 1500403000 15 Wheat, germ 0.490000 1.000 1.000 1500404000 15 Wheat , bran 0.450000 1.000 1.000 1500405000 15 Wild rice 0.150000 1.000 1.000 1800002000 18 Alfalfa, seed 7.000000 1.000 1.000 1901028000 19A Basil, fresh leaves 25.000000 1.000 1.000 1901028001 19A Basil, fresh leaves - babyfood 25.000000 1.000 1.000 1901029000 19A Basil, dried leaves 90.000000 1.000 1.000 1901029001 19A Basil, dried leaves - babyfood 90.000000 1.000 1.000 1901102500 19A Chive, dried leaves 90.000000 1.000 1.000 1901118000 19A Cilantro, leaves 25.000000 1.000 1.000 1901118001 19A Cilantro, leaves - babyfood 25.000000 1.000 1.000 1901144000 19A Dillweed 25.000000 1.000 1.000 1901184000 19A Herbs, other 25.000000 1.000 1.000 1901184001 19A Herbs, other - babyfood 25.000000 1.000 1.000 1901202000 19A Lemongrass 25.000000 1.000 1.000 1901220000 19A Marjoram 25.000000 1.000 1.000 1901220001 19A Marjoram - babyfood 25.000000 1.000 1.000 1901249000 19A Parsley, dried leaves 90.000000 1.000 1.000 1901249001 19A Parsley, dried leaves - babyfood 90.000000 1.000 1.000 1901334000 19A Savory 25.000000 1.000 1.000 1902105000 19B Cinnamo n 90.000000 1.000 1.000 1902105001 19B Cinnamon - babyfood 90.000000 1.000 1.000 1902119000 19B Coriander, seed 90.000000 1.000 1.000 1902119001 19B Coriander, seed - babyfood 90.000000 1.000 1.000 1902143000 19B Dill, seed 90.000000 1.000 1.000 1902274000 19B Pepper, black and white 90.000000 1.000 1.000 1902274001 19B Pepper, black and white - babyfood 90.000000 1.000 1.00 0 1902354000 19B Spices, other 90.000000 1.000 1.000 1902354001 19B Spices, other - babyfood 90.000000 1.000 1.000 2001163000 20A Flax seed, oil 2.000000 1.000 1.000 2001319000 20A Rapes eed, oil 2.000000 1.000 1.000 2001319001 20A Rapeseed, oil - babyfood 2.000000 1.000 1.000 2001336000 20A Sesame, seed 0.300000 1.000 1.000 2001336001 20A Sesame, seed - babyfood 0.300000 1.000 1.000 2001337000 20A Sesame, oil 0.300000 1.000 1.000 2001337001 20A Sesame, oil - babyfood 0.300000 1.000 1.000 2002330000 20B Safflower , oil 2.000000 1.000 1.000 2002330001 20B Safflower, oil - babyfood 2.000000 1.000 1.000 2002364000 20B Sunflower, seed 2.000000 1.000 1.000 2002365000 20B Sunflower, oil 2.000000 1.000 1.000 2002365001 20B Sunflower, oil - babyfood 2.000000 1.000 1.000 2003128000 20C Cottonseed, oil 0.300000 1.000 1.000 2003128001 20C Cottonseed, oil - babyfood 0.300000 1.000 1.000 3100044000 31 Beef, meat 0.100000 1.000 1.000 3100044001 31 Beef, meat - babyfood 0.100000 1.000 1.000 3100045000 31 Beef, meat, dried 0.100000 1.920 1.000 3100046000 31 Beef, m eat byproducts 0.500000 1.000 1.000 3100046001 31 Beef, meat byproducts - babyfood 0.500000 1.000 1.000 3100047000 31 Beef, fat 0.500000 1.000 1.000 3100047001 31 Beef, fat - babyfood 0.500000 1.000 1.000 3100048000 31 Beef, kidney 0.500000 1.000 1.000 3100049000 31 Beef, liver 0.500000 1.000 1.000 3100049001 31 Beef, liver - babyfood 0.500000 1.000 1.00 0 3200169000 32 Goat, meat 0.100000 1.000 1.000 3200170000 32 Goat, meat byproducts 0.500000 1.000 1.000 3200171000 32 Goat, fat 0.500000 1.000 1.000 3200172000 32 Goat, kidney 0.500000 1.000 1.000 3200173000 32 Goat, liver 0.500000 1.000 1.000 3300189000 33 Horse, meat 0.100000 1.000 1.000 3400290000 34 Pork, meat 0.020000 1.000 1.000 3400290001 34 Pork, meat - babyfood 0.020000 1.000 1.000 3400291000 34 Pork, skin 0.050000 1.000 1.000 3400292000 34 Pork, meat byproducts 0.050000 1.000 1.000 3400292001 34 Pork, meat byproducts - babyfood 0.050000 1.000 1.000Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 15 of 22 3400293000 34 Pork, fat 0.050000 1.000 1.000 3400293001 34 Pork, fat - babyfood 0.050000 1.000 1.000 3400294000 34 Pork, kidney 0.050000 1.000 1.000 3400295000 34 Pork, liver 0.050000 1.000 1.000 3500339000 35 Sheep, meat 0.100000 1.000 1.000 3500339001 35 Sheep, meat - babyfood 0.100000 1.000 1.000 3500340000 35 Sheep, meat byproducts 0.500000 1.000 1.000 3500341000 35 Sheep, fat 0.500000 1.000 1.000 3500341001 35 Sheep, fat - babyfood 0.500000 1.000 1.000 3500342000 35 Sheep, kidney 0.500000 1.000 1.000 3500343000 35 Sheep, liver 0.500000 1.000 1.000 3600222000 36 Milk, f at 0.100000 1.000 1.000 3600222001 36 Milk, fat - baby food/infant formu 0.100000 1.000 1.000 3600223000 36 Milk, nonfat solids 0.100000 1.000 1.000 3600223001 36 Milk, nonfat solids - baby food/in 0.100000 1.000 1.000 3600224000 36 Milk, water 0.100000 1.000 1.000 3600224001 36 Milk, water - babyfood/infant form 0.100000 1.000 1.000 3600225001 36 Milk, sugar (lactose) - baby food/ 0.100000 1.000 1.00 0 3800221000 38 Meat, game 0.100000 1.000 1.000 3900312000 39 Rabbit, meat 0.100000 1.000 1.000 4000093000 40 Chicken, meat 0.100000 1.000 1.000 4000093001 40 Chick en, meat - babyfood 0.100000 1.000 1.000 4000094000 40 Chicken, liver 0.310000 1.000 1.000 4000095000 40 Chicken, meat byproducts 0.310000 1.000 1.000 4000095001 40 Chicken, meat byproducts - babyf oo 0.310000 1.000 1.000 4000096000 40 Chicken, fat 0.310000 1.000 1.000 4000096001 40 Chicken, fat - babyfood 0.310000 1.000 1.000 4000097000 40 Chicken, skin 0.310000 1.000 1.000 4000097001 40 Chicken, skin - babyfood 0.310000 1.000 1.000 5000382000 50 Turkey, meat 0.100000 1.000 1.000 5000382001 50 Turkey, m eat - babyfood 0.100000 1.000 1.000 5000383000 50 Turkey, liver 0.310000 1.000 1.000 5000383001 50 Turkey, liver - babyfood 0.310000 1.000 1.000 5000384000 50 Turkey, meat byproducts 0.310000 1.000 1.000 5000384001 50 Turkey, meat byproducts - babyfood 0.310000 1.000 1.000 5000385000 50 Turkey, fat 0.310000 1.000 1.000 5000385001 50 Turkey, fat - babyfood 0.310000 1.000 1.000 5000386000 50 Turkey, skin 0.310000 1.000 1.000 5000386001 50 Turkey, skin - babyfood 0.310000 1.000 1.000 6000301000 60 Poultry, other, meat 0.100000 1.000 1.000 6000302000 60 Poultry , other, liver 0.310000 1.000 1.000 6000303000 60 Poultry, other, meat byproducts 0.310000 1.000 1.000 6000304000 60 Poultry, other, fat 0.310000 1.000 1.000 6000305000 60 Poultry, other, skin 0.310000 1.000 1.000 7000145000 70 Egg, whole 0.840000 1.000 1.000 7000145001 70 Egg, whole - babyfood 0.840000 1.000 1.000 7000146000 70 Egg, white 0.840000 1.000 1.00 0 7000146001 70 Egg, white (solids) - babyfood 0.840000 1.000 1.000 7000147000 70 Egg, yolk 0.840000 1.000 1.000 7000147001 70 Egg, yolk - babyfood 0.840000 1.000 1.000 8000161000 80 Fish - shellfish, crustacean 0.100000 1.000 1.000 8601000000 86A Water, direct, all sources 0.207000 1.000 1.000 8602000000 86B Water, indirect, all sources 0.207000 1.000 1.000 9500001000 O Acerola 2.000000 1.000 1.000 9500016000 O Artichoke, globe 4.000000 1.000 1.000 9500019000 O Asparagus 13.000000 1.000 1.000 9500020000 O Avocado 4.000000 1.000 1.000 9500023000 O Banana 4.000000 1.000 1.000 9500023001 O Banana - babyfood 4.000000 1.000 1.000 9500024000 O Banana, dried 4.000000 3.900 1.000 9500024001 O Banana, dried - babyfood 4.000000 3.900 1.000 9500073000 O Cactus 13.000000 1.000 1.000 9500074000 O Canistel 4.000000 1.000 1.000 9500089000 O Cherimoya 4.000000 1.000 1.000 9500109000 O Cocoa bean, chocolate 1.500000 1.000 1.000 9500110000 O Cocoa bean, powder 1.500000 1.000 1.000 9500111000 O Coconut , meat 0.020000 1.000 1.000Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 16 of 22 9500111001 O Coconut, meat - babyfood 0.020000 1.000 1.000 9500112000 O Coconut, dried 0.020000 1.000 1.000 9500113000 O Coconut, milk 0.020000 1.000 1.000 9500114000 O Coconut, oil 0.020000 1.000 1.000 9500115000 O Coffee, roasted bean 0.400000 1.000 1.000 9500116000 O Coffee, instant 2.000000 1.000 1.00 0 9500151000 O Feijoa 4.000000 1.000 1.000 9500153000 O Fig 4.000000 1.000 1.000 9500154000 O Fig, dried 4.000000 1.000 1.000 9500177000 O Grape , leaves 2.400000 1.000 1.000 9500178000 O Grape, raisin 5.000000 1.000 1.000 9500183000 O Guava 4.000000 1.000 1.000 9500183001 O Guava - babyfood 4.000000 1.000 1.000 9500188000 O Hop 90.000000 1.000 1.000 9500209000 O Longan 4.000000 1.000 1.000 9500211000 O Lychee 2.000000 1.000 1.000 9500212000 O Lychee, dried 2.000000 1.850 1.000 9500215000 O Mango 4.000000 1.000 1.000 9500215001 O Mango - bab yfood 4.000000 1.000 1.000 9500216000 O Mango, dried 4.000000 1.000 1.000 9500217000 O Mango, juice 4.000000 1.000 1.000 9500217001 O Mango, juice - babyfood 4.000000 1.000 1.000 9500235000 O Olive 4.000000 1.000 1.000 9500236000 O Olive, oil 40.000000 1.000 1.000 9500245000 O Papaya 4.000000 1.000 1.000 9500245001 O Papaya - babyfood 4.000000 1.000 1.000 9500246000 O Papaya, dried 4.000000 1.800 1.000 9500247000 O Papaya, juice 4.000000 1.500 1.000 9500252000 O Passion fruit 4.000000 1.000 1.000 9500252001 O Passionfruit - babyfood 4.000000 1.000 1.000 9500253000 O Passionfruit, juice 4.000000 1.000 1.000 9500253001 O Passionfruit, juice - babyfood 4.000000 1.000 1.000 9500263000 O Peanut 0.060000 1.000 1.000 9500264000 O Peanut, butter 0.060000 1.890 1.000 9500265000 O Peanut, oil 0.060000 1.000 1.00 0 9500275000 O Peppermint 9.000000 1.000 1.000 9500276000 O Peppermint, oil 9.000000 1.000 1.000 9500277000 O Persimmon 4.000000 1.000 1.000 9500279000 O Pinea pple 1.500000 1.000 1.000 9500279001 O Pineapple - babyfood 1.500000 1.000 1.000 9500280000 O Pineapple, dried 1.500000 5.000 1.000 9500281000 O Pineapple, juice 1.500000 1.700 1.000 9500281001 O Pineapple, juice - babyfood 1.500000 1.700 1.000 9500283000 O Plantain 4.000000 1.000 1.000 9500284000 O Plantain, dried 4.000000 3.900 1.000 9500289000 O Pomegranate 4.000000 1.000 1.000 9500333000 O Sapote, Mamey 4.000000 1.000 1.000 9500346000 O Soursop 4.000000 1.000 1.000 9500351000 O Spanish lime 4.000000 1.000 1.000 9500352000 O Spearmint 9.000000 1.000 1.000 9500353000 O Spearmint, oil 9.000000 1.000 1.000 9500358000 O Starfruit 4.000000 1.000 1.000 9500361000 O Sugar apple 4.000000 1.000 1.000 9500362000 O Sugarcane, sugar 14.000000 1.000 1.000 9500362001 O Sugarcane, sugar - babyfood 14.000000 1.000 1.000 9500363000 O Sugarcane, molasses 420.000000 1.000 1.000 9500363001 O Sugarcane, molasses - babyfood 420.000000 1.000 1.000 9500372000 O Tea, dr ied 50.000000 1.000 1.000 9500373000 O Tea, instant 50.000000 1.000 1.000Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 17 of 22 

### Attachment 2: Chronic Food Plus Water Results U.S. EPA Ver. 3.16, 03 - 08 - d DEEM - FCID Chronic analysis for CHLORANTRANILIPROLE NHANES 2003 - 2008 2 - day Residue file name: C: \ Documents and Settings \ krury \ My Documents \ My Work Files \ Chlorantraniliprole \ Peanut and Green Onion \ DEEM Files \ CHLORANTRANILIPROLECHRONIC green o nion peanut 110813.R08 Adjustment factor #2 NOT used. Analysis Date 11 - 08 - 2013/13:26:12 Residue file dated: 11 - 08 - 2013/13:25:05 Reference dose (RfD, Chronic) = 1.58 mg/kg bw/day COMMENT 1: Only a chronic endpoint; there is no acute endpoint

=============================================================================== Total exposure by population subgroup

------------------------------------------------------------------------------- Total Exposure

----------------------------------- Population mg/kg Percent of Subgroup body wt/day Rfd

-------------------------------------- ------------- ---------------- Total US Population 0.036207 2.3% Hispanic 0.039090 2.5% Non - Hisp - White 0.035842 2.3% Non - Hisp - Black 0.033738 2.1% Non - Hisp - Other 0.039447 2.5% Nursing Infants 0.034638 2.2% Non - Nursing Infants 0.072500 4.6% Female 13+ PREG 0.032447 2.1% Children 1 - 6 0.087507 5.5% Children 7 - 12 0.042475 2.7% Male 13 - 19 0.027688 1.8% Female 13 - 19/NP 0.026858 1.7% Male 20+ 0.030448 1.9% Female 20+/NP 0.030256 1.9% Seniors 55+ 0.029870 1.9% All Infants 0.060 811 3.8% Female 13 - 50 0.029395 1.9% Children 1 - 2 0.105269 6.7% Children 3 - 5 0.081499 5.2% Children 6 - 12 0.046110 2.9% Youth 13 - 19 0.027234 1.7% Adults 20 - 49 0.030559 1.9% Adults 50 - 99 0.030166 1.9% Female 13 - 49 0.029398 1.9%

-------------------------------------------------------------------------------Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 18 of 22 

### Attachment 3: Structures of Chlorantraniliprole and Possible Metaboli**tes**

**Structures of C**  **hlorantraniliprole and P**  **ossible M**  **etabolites .**  

### Chemical Name; Company Code Structure 3 - Bromo -N

- [4 - chloro - 2 - methyl - 6 - [(methylamino)carbonyl]phenyl] - 1 - (3 - chloro - 2 - py ridinyl) - 1 H

-py razole - 5 - carboxamide Chlorantraniliprole DPX - E2Y45 3 - Bromo - 1 - (3 - chloro - 2 -py ridinyl) - 1 H

- py razole - 5 - carbox yl ic acid IN - DBC80

2 - [3 - Bromo - 1 - (3 - chloro - 2 -py ridinyl) - 1 H

- py razol - 5 - yl ] - 6 - chloro - 3, 8 - dimethyl - 4(3 H ) - quinazolinone IN - EQW78

5 - Bromo -N

- methyl - 1 H

-py razole - 3 - carboxamide IN - F6 L99

N - [2 - (Aminocarbonyl ) - 4 - chloro - 6 - methylphenyl] - 3 - bromo - 1 - (3 - chloro - 2 -py

ridinyl)1 H

-py razole - 5 - carboxamide IN - F9N04

2 - [3 - Bromo - 1 - (3 - chloro - 2 -py ridinyl) - 1 H

- py razol - 5 - yl ] - 6 - chloro - 8 - methyl - 4(3 H

) - quinazolinone IN - GAZ70 **N N**  **N N** **H O**  **Cl Br**  **N H**  **O Cl** 

**N N**  **N O** 

**Cl Br**  **O H** 

**N N**  **N N**  **N Br**  **O**

**Cl Cl** 

**N**

**H N**  **H O**  **N Br** 

**N N**  **N N**  **H O**  **Cl Br**  **O Cl**  **N H**  **2**

**N**

**N H**  **N N**  **N Br**  **O**

**Cl Cl** Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 19 of 22 

### Structures of **C hlorantraniliprole and**  **P ossible**  **M etabolites**  **.** 

### Chemical Name; Company Code Structure 3 - Bromo -N

- [4 - chloro - 2 - [[(hydrox ym ethyl )amino]carbonyl] - 6 - methylphenyl] - 1 - (3 - chloro - 2 -py

ridinyl) - 1 H

-py razole - 5 - carboxamide IN - H2H20

N - [2 - Aminocarbonyl ] - 4 - chloro - 6 - (hydroxy methyl)phenyl] - 3 - bromo - 1 - (3 - chloro - 2 - py ridinyl) - 1 H

-py razole - 5 - carboxamide IN - HXH40

3 - Bromo -N

- [4 - chloro - 2 - (hydrox ym ethyl) - 6 - [(methylamino)carbonyl]phenyl] - 1 - (3 - chloro - 2 - py ridinyl) - 1 H

-py razole - 5 - carboxamide IN - HXH44

2 - [3 - Bromo - 1 - (3 - chloro - 2 -py ridinyl) - 1 H

- py razol - 5 - yl ] - 6 - chloro - 8 - (hydrox ym ethyl) - 4(3 H ) - quinazolinone IN - K7H29 3 - Bromo -N

- [4 - chloro - 2 - (hydrox ym ethyl) - 6 - [[(hydrox ym ethyl )amino)carbonyl ]phenyl] - 1 - (3 - chloro - 2 -py

ridinyl) - 1 H

-py razole - 5 - carboxamide IN - K9T00 **N N**  **N N** **H O**  **Cl Br**  **N H**  **O Cl**  **O H** 

**N N**  **N N** **H O**  **Cl Br**  **N H**  **2 O**  **Cl**

**O H** 

**N N**  **N N** **H O**  **Cl Br**  **N H**  **O Cl** 

**O H** 

**N**

**N H**  **N N**  **N Br**  **O**

**Cl Cl** 

**O H** 

**N N**  **N N** **H O**  **Cl Br**  **N H**  **O Cl** 

**O H**  **O H** Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 20 of 22 

### Structures of **C hlorantraniliprole and**  **P ossible**  **M etabolites**  **.** 

### Chemical Name; Company Code Structure 6 - Chloro - 1, 2, 3, 4 - tetrahydro - 2, 4 - dioxo - 8 - quinazolinecarbox yl ic acid IN - K9X71 2 - [[[3 - Bromo - 1 - (3 - chloro - 2 -py ridinyl) - 1 H

- py razol - 5 - yl ]carbonyl]amino] - 5 - chloro - 3 - [(methylamino)carbonyl]benzoic acid IN - KAA24

2 - Amino - 5 - chloro - 3 - [(methylamino)carbonyl ]benzoic acid IN - L8 F56

IN - E5F18 Not provided **N H**  **N H**  **O**

**O Cl** 

**O H**  **O**

**N N**  **N N** **H O**  **Cl Br**  **N H**  **O Cl**  **O H**  **O**



### O **Cl**

**O H**  **O N** 

**N H**  **2**Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 21 of 22 **Table A.3. 1.**  **Poultry Residue Level Calculations Commodity**  **Nominal**

**Dose (m**  **/k/d )**  **Average Residue Level (ppm) Total (ppm)**  **Chlorantraniliprole IN**  **** **H2H20 IN**  **- K7H29**  **IN**   ** GAZ70** **IN**  

** F9N04** **Eggs** 9 0.296 0.149 0.024 0.139 0.138 Adjusted to 10ppm 0.329 0.165 0.027 0.154 0.153 MW Factor 483/483 =1 483/499 = 0.97 483/467 =

1.03 483/451

= 1.07 483/469

= 1.03 10 Chlorantraniliprole Equivalents 0.329 0.160 0.028 0.165 0.157 0.84 **Liver** 9 0.092 0.092 0.06 0.018 0.0153 Adjusted to 10 ppm 0.102 0.102 0.067 0.02 0.017 MW Factor 1 0.97 1.03 1.07 1.03 10 Chlorantraniliprole Equivalents 0.102 0.099 0.068 0.021 0.018 0.31 **Muscle (Meat)** 9 0.027 0.028 0.002 0.001 0.031 Adjusted to 10 ppm 0.03 0.031 0.002 0.001 0.034 MW Factor 1 0.97 1.03 1.07 1.03 10 Chlorantraniliprole Equivalents 0.03 0.302 0.0023 0.0012 0.035 0.10 **Skin/Fat** 9 0.096 0.068 0.004 0.008 0.103 Adjusted to 10 ppm 0.107 0.076 0.0044 0.0089 0.11 MW Factor 1 0.97 1.03 1.07 1.03 10 Chlorantraniliprole Equivalents 0.1067 0.073 0.0046 0.0095 0.12 0.31 1 . The day that gives the highest residue value was day 14

– which was chosen to calculate the residue levels. Using only average values as this is a chronic dietary analysis. For additional details see D407350; D410513; D412173 .Chlorantraniliprole Dietary Exposure and Risk Assessment DP Number: D416093

Page 22 of 22 **Table A.3. 2**  **Ruminant Residue Level Calculations**  **1 Commodity**  **Nominal Dose**  **(m /k**  **/d) Average Residue Level (ppm)**  **Current Tolerance**  **(ppm) Chlorantraniliprole**  **IN**   ** HXH44** **IN -**  **K9T00 Total**  **(ppm) Mi** **lk** 50 0.027 0.03 0.012 Adjusted to 80ppm 0.043 0.048 0.019 MW Factor 483/483 = 1 483/499 = 0.97 483/515 =

0.94 10 Chlorantraniliprole Equivalents 0.043 0.047 0.018 0.11 0.1 **Liver** 0.13 0.045 0.005 Adjusted to 115 ppm 50 0.299 0.104 0.012 MW Factor 1 0.97 0.94 10 Chlorantraniliprole Equivalents 0.299 0.1003 0.012 0.41 0.5 **Kidney** 50 0.068 0.039 0.012 Adjusted to 1 15 ppm 0.1564 0.0897 0.0276 MW Factor 1 0.97 0.94 10 Chlorantraniliprole Equivalents 0.1564 0.08700 9 0.025844 0.27 0.5 **Fat** 50 0.14 0.012 0 Adjusted to 1 15 ppm 0.322 0.0276 0 MW Factor 1 0.97 0.94 10 Chlorantraniliprole Equivalents 0.322 0.02677 2 0 0.35 0.5 **Meat (m uscle)**  50 0.019 0.009 0 Adjusted to 1 15 ppm 0.0437 0.0207 0 MW Factor 1 0.97 0.94 10 Chlorantraniliprole Equivalents 0.0437 0.02007 9 0 0.06 0.1 1. The latest ruminant burden levels are 80 ppm for diary cattle and 115 ppm for beef cattle (D404708, 09/10/2013). The highest feeding level was 50 ppm (Monograph B7, IIA.B.7.8.1, page 700 ff) .