### Appendix 6. Key Deltamethrin Studies

A6 - 1 Neurotoxicity Brodie, M. E. (1985) . "Deltamethrin infusion into different sites in the neuraxis of freely - moving rats." Neurobehav Toxicol Teratol 7(1): 51 - 55. Eells, J. T., P. A. Bandettini, et al. (1992). "Pyrethroid insecticide - induced alterations in mammalian synaptic membrane potential." J Pharmacol Exp Ther 262(3): 1173 - 1181. Gray, A. J. and J. Rickard (1982). "Toxicity of pyrethroids to rats after direct injection into the central nervous system." Neu rotoxicology 3(1): 25 - 35. Motomura, H. and T. Narahashi (2001). "Interaction of tetramethrin and deltamethrin at the single sodium channel in rat hippocampal neurons." Neurotoxicology 22(3): 329 - 339. Narahashi, T. (1982). "Cellular and molecular mechanisms of action of insecticides: neurophysiological approach." Neurobehav Toxicol Teratol 4(6): 753 - 758. Narahashi, T., J. M. Frey, et al. (1992). "Sodium and GABA - activated channels as the targets of pyrethroids and cyclodienes." Toxicol Lett 64 - 65 Spec No: 42 9 - 436. Shafer, T. J. and M. F. Hughes (2010). "Accumulation of pyrethroid compounds in primary cultures from rat cortex." Toxicol In Vitro 24(7): 2053 - 2057. Shafer, T. J., S. O. Rijal, et al. (2008). "Complete inhibition of spontaneous activity in neuronal networks in vitro by deltamethrin and permethrin." Neurotoxicology 29(2): 203 - 212. FOB Crofton, K. M. and L. W. Reiter (1984). "Effects of two pyrethroid insecticides on motor activity and the acoustic startle response in the rat." Toxicol Appl Pharmacol 75(2): 318 - 328. Crofton, K. M. and L. W. Reiter (1987). "Pyrethroid insecticides and the gamma - aminobutyric acidA receptor complex: motor activity and the acoustic startle response in the rat." J Pharmacol Exp Ther 243(3): 946 - 954. Crofton, K. M. and L. W. Reiter (1988). "The effects of type I and II pyrethroids on motor activity and the acoustic startle response in the rat." Fundam Appl Toxicol 10(4): 624 - 634. Crofton, K. M. and L. W. Reiter (1984). "Effects of two pyrethroid insecticides on moto r activity and the acoustic startle response in the rat." Toxicol Appl Pharmacol 75(2): 318 - 328. Dayal, M., D. Parmar, et al. (2003). "Effect of pretreatment of cytochrome P450 (P450) modifiers on neurobehavioral toxicity induced by deltamethrin." Food Che m Toxicol 41(3): 431 - 437. Husain, R., V. M. Adhami, et al. (1996). "Behavioral, neurochemical, and neuromorphological effects of deltamethrin in adult rats." J Toxicol Environ Health 48(5): 515 - 526. Lazarini, C. A., J. C. Florio, et al. (2001). "Effects of prenatal exposure to deltamethrin on forced swimming behavior, motor activity, and striatal dopamine levels in male and female rats." Neurotoxicol Teratol 23(6): 665 - 673. Ray, D. E. (1980). "An EEG investigation of decamethrin - induced choreoat hetosis in the rat." Exp Brain Res 38(2): 221 - 227. Sheets, L. P. (2000). "A consideration of age - dependent differences in susceptibility to organophosphorus and pyrethroid insecticides." Neurotoxicology 21(1 - 2): 57 - 63. Sheets, L. P., J. D. Doherty, et al. (1994). "Age - dependent differences in the susceptibility of rats to deltamethrin." Toxicol Appl Pharmacol 126(1): 186 - 190. Wolansky, M. J., C. Gennings, et al. (2006). "Relative potencies for acute effects of pyrethroids on motor function in rats." Toxico l Sci 89(1): 271 - 277.

### Appendix 6. Key Deltamethrin Studies

A6 - 2 Wolansky, M. J. and J. A. Harrill (2008). "Neurobehavioral toxicology of pyrethroid insecticides in adult animals: a critical review." Neurotoxicol Teratol 30(2): 55 - 78. MOA Breckenridge, C. B., L. Holden, et al. (2009). "Evidence for a separate mechanism of toxicity for the Type I and the Type II pyrethroid insecticides." Neurotoxicology 30 Suppl 1: S17 - 31. Weiner, M. L., M. Nemec, et al. (2009). "Comparative functional observational battery study of twelve commercial pyr ethroid insecticides in male rats following acute oral exposure." Neurotoxicology 30 Suppl 1: S1 - 16. Sodium Channel Cao, Z., T. J. Shafer, et al. (2011). "Additivity of Pyrethroid Actions on Sodium Influx in Cerebrocortical Neurons in Primary Culture." Environ Health Perspect. Choi, J. S. and D. M. Soderlund (2004). "Cyclosporin A and deltamethrin block the downregulation of Nav1.8 sodium channels expressed in Xenopus oocytes." Neurosci Lett 367(3): 389 - 393. Choi, J. S. and D. M. Soderlund (2006). "Structure - activity relationships for the action of 11 pyrethroid insecticides on rat Na v 1.8 sodium channels expressed in Xenopus oocytes." Toxicol Appl Pharmacol 211(3): 233 - 244. Du, Y., Y. Nomura, et al. (2009). "Molecular deter minants on the insect sodium channel for the specific action of type II pyrethroid insecticides." Toxicol Appl Pharmacol 234(2): 266 - 272. Hu, Z., Y. Du, et al. (2011). "A sodium channel mutation identified in Aedes aegypti selectively reduces cockroach sod ium channel sensitivity to type I, but not type II pyrethroids." Insect Biochem Mol Biol 41(1): 9 - 13. Meacham, C. A., P. D. Brodfuehrer, et al. (2008). "Developmentally - regulated sodium channel subunits are differentially sensitive to alpha - cyano containin g pyrethroids." Toxicol Appl Pharmacol 231(3): 273 - 281. Peng, F., I. R. Mellor, et al. (2009). "Single channel study of deltamethrin interactions with wild type and mutated rat Na(V)1.2 sodium channels expressed in Xenopus oocytes." Neurotoxicology 30(3): 358 - 367. Tabarean, I. V. and T. Narahashi (2001). "Kinetics of modulation of tetrodotoxin - sensitive and tetrodotoxin - resistant sodium channels by tetramethrin and deltamethrin." J Pharmacol Exp Ther 299(3): 988 - 997. Tan, J., Z. Liu, et al. (2002). "Alterna tive splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels." J Neurosci 22(13): 5300 - 5309. Tan, J., Z. Liu, et al. (2002). "Novel sodium channel gene mutations in Blattella germanica reduce the sensitivity of expres sed channels to deltamethrin." Insect Biochem Mol Biol 32(4): 445 - 454. Tan, J. and D. M. Soderlund (2010). "Divergent actions of the pyrethroid insecticides S bioallethrin, tefluthrin, and deltamethrin on rat Na(v)1.6 sodium channels." Toxicol Appl Pharmac ol 247(3): 229 - 237. Vais, H., M. S. Williamson, et al. (2001). "The molecular interactions of pyrethroid insecticides with insect and mammalian sodium channels." Pest Manag Sci 57(10): 877 - 888. Vickery, R. G., S. M. Amagasu, et al. (2004). "Comparison of t he pharmacological properties of

### Appendix 6. Key Deltamethrin Studies

A6 - 3 rat Na(V)1.8 with rat Na(V)1.2a and human Na(V)1.5 voltage - gated sodium channel subtypes using a membrane potential sensitive dye and FLIPR." Receptors Channels 10(1): 11 - 23. Wang, S. Y., M. Barile, et al. (2001). "A phenyl alanine residue at segment D3 - S6 in Nav1.4 voltage - gated Na(+) channels is critical for pyrethroid action." Mol Pharmacol 60(3): 620 - 628.