40850 Federal Register / Vol. 76, No. 133 / Tuesday, July 12, 2011 / Proposed Rules 

application noting the month to be used 

as the start of the revised payment 

period. The date selected must be before 

the end of the current payment period. 

The unused fee for the period being 

discontinued may be refunded under 

4.7, and the fee for the new payment 

period must be fully paid in advance. 

Except when boxes from two or more 

ZIP Codes are being merged into a single 

location (see 4.5.4), a change of payment 

period date must not be used to 

circumvent a change in box fees. 

* * * * * 

4.6 Fee Groups 

4.6.1 Regular Fee Groups 

[Revise 4.6.1 as follows:] 

For Post Office box fee groups, see 

Notice 123—Price List. Post Office 

boxes are assigned to fee groups and 

classified as competitive or market 

dominant based upon the Post Office 

location. Local Post Offices can provide 

information about fees for a particular 

ZIP Code. 

* * * * * 

We will publish an appropriate 

amendment to 39 CFR part 111 to reflect 

these changes if our proposal is 

adopted. 

Stanley F. Mires, 

Chief Counsel, Legislative. 

[FR Doc. 2011–17386 Filed 7–11–11; 8:45 am] 

BILLING CODE 7710–12–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

40 CFR Part 721 

[EPA–HQ–OPPT–2009–0767; FRL–8877–8] 

RIN 2070–AJ52 

Glymes; Proposed Significant New Use 

Rule 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Proposed rule. 

SUMMARY: EPA is proposing a significant 

new use rule (SNUR) under section 

5(a)(2) of the Toxic Substances Control 

Act (TSCA) for the 14 glymes identified 

in this proposed rule. This action would 

require persons who intend to 

manufacture, import, or process these 

chemical substances for an activity that 

is designated as a significant new use by 

this proposed rule to notify EPA at least 

90 days before commencing that 

activity. The required notification 

would provide EPA with the 

opportunity to evaluate the intended 

use and, if necessary, to prohibit or limit 

that activity before it occurs. 

DATES: Comments must be received on 

or before September 12, 2011. 

ADDRESSES: Submit your comments, 

identified by docket identification (ID) 

number EPA–HQ–OPPT–2009–0767, by 

one of the following methods: 

• Federal eRulemaking Portal: http:// 

www.regulations.gov. Follow the on-line 

instructions for submitting comments. 

• Mail: Document Control Office 

(7407M), Office of Pollution Prevention 

and Toxics (OPPT), Environmental 

Protection Agency, 1200 Pennsylvania 

Ave., NW., Washington, DC 20460– 

0001. 

• Hand Delivery: OPPT Document 

Control Office (DCO), EPA East Bldg., 

Rm. 6428, 1201 Constitution Ave., NW., 

Washington, DC. Attention: Docket ID 

Number EPA–HQ–OPPT–2009–0767. 

The DCO is open from 8 a.m. to 4 p.m., 

Monday through Friday, excluding legal 

holidays. The telephone number for the 

DCO is (202) 564–8930. Such deliveries 

are only accepted during the DCO’s 

normal hours of operation, and special 

arrangements should be made for 

deliveries of boxed information. 

Instructions: Direct your comments to 

docket ID number EPA–HQ–OPPT– 

2009–0767. EPA’s policy is that all 

comments received will be included in 

the docket without change and may be 

made available on-line at http:// 

www.regulations.gov, including any 

personal information provided, unless 

the comment includes information 

claimed to be Confidential Business 

Information (CBI) or other information 

whose disclosure is restricted by statute. 

Do not submit information that you 

consider to be CBI or otherwise 

protected through regulations.gov or 

e-mail. The regulations.gov Web site is 

an ‘‘anonymous access’’ system, which 

means EPA will not know your identity 

or contact information unless you 

provide it in the body of your comment. 

If you send an e-mail comment directly 

to EPA without going through 

regulations.gov, your e-mail address 

will be automatically captured and 

included as part of the comment that is 

placed in the docket and made available 

on the Internet. If you submit an 

electronic comment, EPA recommends 

that you include your name and other 

contact information in the body of your 

comment and with any disk or CD–ROM 

you submit. If EPA cannot read your 

comment due to technical difficulties 

and cannot contact you for clarification, 

EPA may not be able to consider your 

comment. Electronic files should avoid 

the use of special characters, any form 

of encryption, and be free of any defects 

or viruses. 

Docket: All documents in the docket 

are listed in the docket index available 

at http://www.regulations.gov. Although 

listed in the index, some information is 

not publicly available, e.g., CBI or other 

information whose disclosure is 

restricted by statute. Certain other 

material, such as copyrighted material, 

will be publicly available only in hard 

copy. Publicly available docket 

materials are available electronically at 

http://www.regulations.gov, or, if only 

available in hard copy, at the OPPT 

Docket. The OPPT Docket is located in 

the EPA Docket Center (EPA/DC) at 

Rm. 3334, EPA West Bldg., 1301 

Constitution Ave., NW., Washington, 

DC. The EPA/DC Public Reading Room 

hours of operation are 8:30 a.m. to 

4:30 p.m., Monday through Friday, 

excluding legal holidays. The telephone 

number of the EPA/DC Public Reading 

Room is (202) 566–1744, and the 

telephone number for the OPPT Docket 

is (202) 566–0280. Docket visitors are 

required to show photographic 

identification, pass through a metal 

detector, and sign the EPA visitor log. 

All visitor bags are processed through 

an X-ray machine and subject to search. 

Visitors will be provided an EPA/DC 

badge that must be visible at all times 

in the building and returned upon 

departure. 

FOR FURTHER INFORMATION CONTACT: For 

technical information contact: Amy 

Breedlove, Chemical Control Division 

(7405M), Office of Pollution Prevention 

and Toxics, Environmental Protection 

Agency, 1200 Pennsylvania Ave., NW., 

Washington, DC 20460–0001; telephone 

number: 202–564–9823; e-mail address: 

breedlove.amy@epa.gov. 

For general information contact: The 

TSCA-Hotline, ABVI-Goodwill, 422 

South Clinton Ave., Rochester, NY 

14620; telephone number: (202) 554– 

1404; e-mail address: TSCA– 

Hotline@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. General Information 

A. Does this action apply to me? 

You may be potentially affected by 

this action if you manufacture, import, 

or process the chemicals listed in Unit 

III.A. Potentially affected entities may 

include, but are not limited to: 

• Manufacturers, importers, or 

processors of one or more of subject 

chemical substances (North American 

Industrial Classification System 

(NAICS) codes 325 and 324110), e.g., 

chemical manufacturing and petroleum 

refineries; 

• All other basic organic chemical 

manufacturing (NAICS 325199); 

• Printing ink manufacturing (NAICS 

325910); 


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• Paint and Coating Manufacturing 

(NAICS 325510); 

• Adhesive Manufacturing (NAICS 

325520); 

• Primary Battery Manufacturing 

(NAICS 335912); and 

• Motor Vehicle Brake System 

Manufacturing (NAICS 336340). 

This listing is not intended to be 

exhaustive, but rather provides a guide 

for readers regarding entities likely to be 

affected by this action. Other types of 

entities not listed in this unit could also 

be affected. The NAICS codes have been 

provided to assist you and others in 

determining whether this action might 

apply to certain entities. To determine 

whether you or your business may be 

affected by this action, you should 

carefully examine the applicability 

provisions in 40 CFR 721.5. If you have 

any questions regarding the 

applicability of this action to a 

particular entity, consult the technical 

person listed under FOR FURTHER

INFORMATION CONTACT. 

This action may also affect certain 

entities through pre-existing import 

certification and export notification 

rules under TSCA. Persons who import 

any chemical substance governed by a 

final SNUR are subject to the TSCA 

section 13 (15 U.S.C. 2612) import 

certification requirements and the 

corresponding regulations at 19 CFR 

12.118 through 12.127; see also 19 CFR 

127.28. Those persons must certify that 

the shipment of the chemical substance 

complies with all applicable rules and 

orders under TSCA, including any 

SNUR requirements. The EPA policy in 

support of import certification appears 

at 40 CFR part 707, subpart B. In 

addition, any persons who export or 

intend to export a chemical substance 

that is the subject of this proposed rule 

on or after August 11, 2011 are subject 

to the export notification provisions of 

TSCA section 12(b) (15 U.S.C. 2611(b)), 

(see 40 CFR 721.20), and must comply 

with the export notification 

requirements in 40 CFR part 707, 

subpart D. 

B. What should I consider as I prepare 

my comments for EPA? 

1. Submitting CBI. Do not submit 

confidential business information (CBI) 

to EPA through regulations.gov or 

e-mail. Clearly mark the part or all of 

the information that you claim to be 

CBI. For CBI information in a disk or 

CD–ROM that you mail to EPA, mark 

the outside of the disk or CD–ROM as 

CBI and then identify electronically 

within the disk or CD–ROM the specific 

information that is claimed as CBI. In 

addition to one complete version of the 

comment that includes information 

claimed as CBI, a redacted copy of the 

comment that does not contain the 

information claimed as CBI must be 

submitted for inclusion in the public 

docket. Information so marked will not 

be disclosed except in accordance with 

procedures set forth in 40 CFR part 2. 

2. Tips for preparing your comments. 

When submitting comments, remember 

to: 

i. Identify the document by docket ID 

number and other identifying 

information (subject heading, Federal 

Register date and page number). 

ii. Follow directions. The Agency may 

ask you to respond to specific questions 

or organize comments by referencing a 

Code of Federal Regulations (CFR) part 

or section number. 

iii. Explain why you agree or disagree; 

suggest alternatives and substitute 

language for your requested changes. 

iv. Describe any assumptions and 

provide any technical information and/ 

or data that you used. 

v. If you estimate potential costs or 

burdens, explain how you arrived at 

your estimate in sufficient detail to 

allow for it to be reproduced. 

vi. Provide specific examples to 

illustrate your concerns and suggest 

alternatives. 

vii. Explain your views as clearly as 

possible, avoiding the use of profanity 

or personal 

threats. 

viii. Make sure to submit your 

comments by the comment period 

deadline identified. 

II. Background 

A. What is the agency’s authority for 

taking this action? 

Section 5(a)(2) of TSCA (15 U.S.C. 

2604(a)(2)) authorizes EPA to determine 

that a use of a chemical substance is a 

‘‘significant new use.’’ Since on-going 

uses are by definition, not new, they are 

identified and excluded from the SNUR. 

EPA must make the determination of a 

‘‘significant new use’’ by rule after 

considering all relevant factors, 

including those listed in TSCA section 

5(a)(2). The relevant factors to be 

considered are: 

• The projected volume of 

manufacturing and processing of a 

chemical substance. 

• The extent to which a use changes 

the type or form of exposure of human 

beings or the environment to a chemical 

substance. 

• The extent to which a use increases 

the magnitude and duration of exposure 

of human beings or the environment to 

a chemical substance. 

• The reasonably anticipated manner 

and methods of manufacturing, 

processing, distribution in commerce, 

and disposal of a chemical substance. 

• In addition to the factors 

enumerated in TSCA section 5(a)(2), the 

statute authorizes EPA to consider any 

other relevant factors. 

Once EPA determines that a use of a 

chemical substance is a significant new 

use, TSCA section 5(a)(1)(B) requires 

persons to submit a significant new use 

notice (SNUN) to EPA at least 90 days 

before they manufacture, import, or 

process the chemical substance for that 

use (15 U.S.C. 2604(a)(1)(B)). As 

described in Unit VII., the general SNUR 

provisions are found at 40 CFR Part 721, 

Subpart A. 

Section 26(c) of TSCA (15 U.S.C. 

2625(c)) authorizes EPA to take action 

under other sections of TSCA with 

respect to categories of chemical 

substances. 

B. Why is the agency taking this action? 

EPA has concerns about the 14 glymes 

listed in this SNUR, all of which have 

similar chemical structures. EPA is 

concerned about the reproductive and/ 

or developmental toxicity of 

monoglyme, diglyme, and ethylglyme 

and believes that individuals could 

suffer adverse effects from their use. In 

addition, EPA has concerns about the 

remaining 11 glymes due to the lack of 

available use, exposure, and toxicity 

information. Currently, exposure to 

monoglyme in lithium batteries is very 

limited since the batteries are sealed. 

The amount of exposure to diglyme in 

printing inks is less certain, but any 

additional use would increase the 

existing exposure to the chemical. 

Ethylglyme currently has no consumer 

uses but has been found in water 

sources, its production level appears to 

be increasing, and given its toxicity, 

EPA would be concerned if this 

chemical substance became prevalent in 

consumer products. EPA further 

believes that the use of any of these 

chemical substances in consumer 

products, beyond the limited, on-going 

current uses, could significantly 

increase the magnitude and duration of 

exposure to humans and the 

environment over that which would 

otherwise exist and that such increase 

should not occur without opportunity 

for EPA review. Finally, for 

pentaethylene glycol dibutyl ether and 

butyltriglyme, which presently show no 

reported production to the IUR or any 

ongoing uses, EPA believes that any use 

of these chemical substances could be a 

significant increase in the magnitude 

and duration of exposure to humans and 

the environment over that which 

currently exist. 


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On March 18, 2008, EPA published 

risk based prioritization related 

documents on monoglyme and diglyme 

(Refs. 1, 2, 3, and 4), which indicated 

that it appeared these two chemical 

substances are used in consumer 

products and also indicated EPA’s 

concerns about the potential health 

effects of these two chemical 

substances. Studies on monoglyme and 

diglyme indicate adverse health effects 

concerning reproductive and 

developmental toxicity, as well as on 

blood and blood-forming organs. 

Studies on ethylglyme show 

developmental toxicity as well as 

potential for gene mutation. Several 

manufacturers initially responded that, 

with the exception of monoglyme use in 

sealed lithium batteries, there are no 

consumer uses. Follow up contact with 

manufacturers revealed some additional 

potential consumer uses and raised 

questions about some of the other uses. 

For monoglyme, diglyme, and 

ethylglyme, as well as the remaining 11 

chemicals, the level of toxicity is 

uncertain and/or the type and extent of 

the use of the chemical substance is 

unclear. EPA is proposing to issue this 

SNUR to require notification prior to 

any new manufacturing, importing, or 

processing of these chemicals for 

consumer uses (with specified 

exceptions), or in some cases all uses. 

EPA intends to continue to monitor 

production, use and other relevant 

information on the subject substances 

and, where appropriate, initiate further 

action. 

EPA previously published a SNUR on 

November 29, 2005, (70 FR 71401), 

(FRL–7740–7), on a major metabolite of 

monoglyme, 2-methoxyethanol (2-ME), 

CASRN 109–86–4, requiring notice to 

the Agency before 2-ME is used in a 

consumer product (40 CFR 721.10001) 

(Ref. 5). 

III. Significant New Use Determination 

A. What chemicals are included in this 

SNUR? 

The proposed category of glymes to be 

regulated by this SNUR consists of the 

14 chemical substances shown in Table 

1 and Table 2. Specifically, the 

designated significant new use for the 

glymes chemicals in Table 1 of this unit 

would be ‘‘use in a consumer product,’’ 

with the exception of the ongoing uses 

which are the excluded uses listed 

under ‘‘Proposed Excluded Consumer 

Uses,’’ and where the designated 

significant new use for the chemicals in 

Table 2 would be ‘‘any use.’’ ‘‘Consumer 

product’’ is defined at 40 CFR 721.3 as: 

‘‘a chemical substance that is directly, 

or as part of a mixture, sold or made 

available to consumers for their use in 

or around a permanent or temporary 

household or residence, in or around a 

school, or in recreation.’’ 

While hazard data are only currently 

available for 3 of the 14 chemical 

substances in this category (see Unit 

IV.D.), EPA is proposing to designate 

significant new uses for all 14 chemical 

substances listed in Tables 1 and 2 on 

the basis of the available information. 

Consistent with its authority under 

TSCA section 26(c), EPA is proposing to 

make all 14 chemical substances subject 

to the significant new use rule based on 

similarities in the molecular structures, 

physical and chemical properties, uses, 

and potential uses of the chemical 

substances in the category. EPA 

acknowledges that there are differences 

in the ongoing uses of the 14 chemical 

substances, and has accounted for those 

differences by varying the proposed 

significant new use designations for the 

chemical substances, as shown in 

Tables 1 and 2. Nonetheless, EPA 

believes that the chemicals are 

sufficiently similar such that it is 

appropriate, for purposes of this SNUR, 

to act on them together. EPA solicits 

public comment on the scope of the 

chemical substances to be subject to this 

SNUR. Specifically, whether any of the 

chemical substances included in the 

category are sufficiently dissimilar from 

the rest that they should be removed 

from the category, or whether any 

additional chemical substances are 

sufficiently similar that they should be 

added to the category. 

TABLE 1—CHEMICALS WITH USE IN A CONSUMER PRODUCT AS THE PROPOSED SIGNIFICANT NEW USE AND PROPOSED

EXCLUDED CONSUMER USES

Chemical Abstract 

Service 

(CAS) Registry No. 

(CASRN) 

Chemical abstract index name Common name Proposed excluded consumer uses 

110–71–4 ................ Ethane, 1,2-dimethoxy- ........................ Monoglyme or Monoethylene glycol dimethyl ether.In electrolyte solutions for sealed lithium batteries. 

111–96–6 ................ Ethane, 1,1′-oxybis[2-methoxy- ............ Diglyme or Diethylene glycol dimethyl 

ether.

As a solvent in printing inks for consumer products. 

112–36–7 ................ Ethane, 1,1′-oxybis[2-ethoxy- ............... Ethyldiglyme or Diethylene glycol 

diethyl ether.

112–49–2 ................ 2,5,8,11-Tetraoxadodecane ................. Triglyme or Triethylene glycol dimethyl 

ether.

—As a solvent in consumer adhesives. 

—As a component of consumer brake 

fluids. 

—As a component of consumer paint/ 

graffiti removers. 

—in consumer paints. 

112–73–2 ................ Butane, 1,1′-[oxybis(2,1- 

ethanediyloxy)]bis-.

Butyldiglyme or Diethylene glycol 

dibutyl ether.

112–98–1 ................ 5,8,11,14,17-Pentaoxaheneicosane ..... Tetraethylene glycol dibutyl ether.

143–24–8 ................ 2,5,8,11,14-Pentaoxapentadecane ...... Tetraglyme or Tetraethylene glycol dimethyl ether.—As an HFC/CFC lubricant. 

—As a solubilizing agent for consumer 

printing inks. 

—As a coalescing agent in consumer 

paints. 

629–14–1 ................ Ethane, 1,2-diethoxy- ........................... Ethylglyme or Ethylene glycol diethyl 

ether.

4353–28–0 .............. 3,6,9,12,15-Pentaoxaheptadecane ...... Tetraethylene glycol diethyl ether.

23601–39–0 ............ 3,6,9,12,15,18-Hexaoxaeicosane ......... Pentaethylene glycol diethyl ether.


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TABLE 1—CHEMICALS WITH USE IN A CONSUMER PRODUCT AS THE PROPOSED SIGNIFICANT NEW USE AND PROPOSED

EXCLUDED CONSUMER USES—Continued 

Chemical Abstract 

Service 

(CAS) Registry No. 

(CASRN) 

Chemical abstract index name Common name Proposed excluded consumer uses 

24991–55–7 ............ Poly(oxy-1,2-ethanediyl), .alpha.-methyl-.omega.-methoxy-.Polyglyme or Polyethylene glycol dimethyl ether.Use in consumer paint strippers. 

31885–97–9 ............ Poly(oxy-1,2-ethanediyl), .alpha.-butyl- 

.omega.-butoxy-.

Polyethylene glycol dibutyl ether.

TABLE 2—CHEMICALS WITH ‘‘ANY USE’’ AS THE PROPOSED SIGNIFICANT NEW USE

Chemical Abstract Service 

(CAS) Registry No. 

(CASRN) 

Chemical abstract index name Common name 

51105–00–1 ......................... 5,8,11,14,17,20-Hexaoxatetracosane ............................. Pentaethylene glycol dibutyl ether. 

63512–36–7 ......................... 5,8,11,14-Tetraoxaoctadecane ....................................... Butyltriglyme or Triethylene glycol dibutyl ether. 

B. What relevant factors were 

considered for this SNUR? 

To develop its preliminary 

determination of what would constitute 

a significant new use of the glymes 

listed in Table 1 and Table 2, EPA 

considered relevant information about 

the toxicity of these substances, likely 

human exposures and environmental 

releases associated with possible uses, 

and the four factors listed in section 

5(a)(2) of TSCA and Unit II.A. of this 

proposed SNUR. 

The latest information available to 

EPA, which is summarized in Unit IV. 

of this SNUR, indicates that based on 

historical production levels of five of 

these chemicals, any production or 

commencement of Inventory Update 

Reporting (IUR) reporting would be 

considered a significant change. For the 

two chemicals which currently do not 

appear to be in production or use, 

commencement of production for any 

use could result in a significant increase 

in the type and form of exposure to both 

humans and the environment. For the 

seven chemicals which currently do not 

have ongoing consumer uses, any 

commencement of use in a consumer 

product would change the type of 

exposure to humans from indirect to 

direct exposure and the form of 

exposure from primarily inhalation to 

both inhalation and skin exposure. 

EPA believes that any shift from a 

status of no uses in a consumer product 

to any use in a consumer product would 

increase the magnitude and duration of 

exposure to consumers than would 

otherwise exist since use of a consumer 

product could result in more frequent, 

direct, and longer exposures than the 

infrequent or indirect exposures that 

currently exist. Additional workers are 

also likely to be exposed, as is the 

surrounding environment at 

manufacturing or processing sites, due 

to possible increases in releases which 

could contribute additional glymes into 

the environment. Finally, EPA believes 

that any changes in the reasonably 

anticipated manner and methods of 

manufacturing, processing, distribution 

in commerce, or disposal of these 

glymes could contribute to the type, 

form, magnitude and duration of 

exposure to humans and the 

environment. 

Based on these relevant factors, EPA 

has preliminarily determined that the 

manufacture, import, or processing of 

ethyldiglyme, butyldiglyme, 

tetraethylene glycol dibutyl ether, 

ethylglyme, tetraethylene glycol diethyl 

ether, pentaethylene glycol diethyl 

ether, and polyethylene glycol dibutyl 

ether for any use in a consumer product 

is a significant new use. EPA has also 

primarily determined that the 

manufacture, import, or processing of 

monoglyme, diglyme, triglyme, 

tetraglyme, polyglyme for any use in a 

consumer product, other than for the 

ongoing uses listed in Table 1, is a 

significant new use. In addition, EPA 

has primarily determined that the 

manufacture, import, or processing of 

pentaethylene glycol dibutyl ether and 

butyltriglyme for any use is a significant 

new use. 

C. What are EPA objectives for this 

SNUR? 

EPA wants to achieve the following 

objectives with regard to the significant 

new use(s) that are designated in this 

proposed rule: 

1. EPA would receive notice of any 

person’s intent to manufacture, import, 

or process the glymes listed in Table 1 

and Table 2 for the described significant 

new uses before that activity begins. 

2. EPA would have an opportunity to 

review and evaluate data submitted in a 

SNUN before the notice submitter 

begins manufacturing, importing or 

processing of the glymes listed in Table 

1 and Table 2 for the described 

significant new uses. 

3. EPA would be able to regulate 

prospective uses of the glymes listed in 

Table 1 and Table 2 before the described 

significant new uses of the chemical 

substance occur, provided that 

regulation is warranted pursuant to 

TSCA sections 5(e), 5(f), 6 or 7. 

IV. Summary of Relevant Available 

Information on the Glymes 

A. What are the ongoing uses of these 

chemicals? 

1. Known Ongoing Uses of Glymes. To 

identify the ongoing consumer uses of 

these glymes, as well as potential 

industrial uses, EPA used information 

submitted under the 2006 IUR rule, 

contacted manufacturers, searched 

business periodicals, and searched other 

available sources. Monoglyme is used in 

consumer products in electrolyte 

solutions for sealed lithium batteries. 

Industrial uses include printed circuit 

board manufacturing; in reactions with 

strong bases; in mixtures where solvent 

separation and recovery is necessary; as 

an inert special solvent; and as a solvent 

in pharmaceutical production (Ref. 6, 

p. 9). 

Diglyme is used as a solvent in 

printing inks for consumer products and 

industrially as a solvent in a variety of 

processes (Ref. 6, p. 10). 

Triglyme is used in consumer 

products in consumer brake fluids, as a 

solvent in consumer adhesives, as a 

component of consumer paint and 

graffiti removers and in consumer 

paints. Industrial uses include 


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generation of chemicals, use as a 

reaction solvent, and use as a binding 

agent in porcelain powders (Ref. 6, 

p. 11). 

Tetraglyme is used in consumer 

products as a solubilizing agent for 

consumer printing inks, as a coalescing 

agent in consumer paints, and as an 

HFC/CFC lubricant which may be used 

in consumer air conditioners. Industrial 

uses include use as a solubilizing agent 

in textiles and plastics, as a dye fixation 

additive for cotton textiles, as a 

fungicide process solvent, and as a gas 

scrubbing agent (Ref. 6, p. 12). 

Polyglyme is used in consumer paint 

strippers. Industrial uses include use as 

special, high boiling solvents for 

chemical reactions, use as a solubilizing 

agent for plastic, textile, and paper 

processes, and use as a gas scrubbing 

agent (Ref. 6, p. 13). 

Ethyldiglyme, butyldiglyme, 

tetraethylene glycol dibutyl ether, 

ethylglyme, tetraethylene glycol diethyl 

ether, pentaethylene glycol diethyl 

ether, and polyethylene glycol dibutyl 

ether, have no known uses in consumer 

products. Industrial uses of these 

glymes can include use: as a highboiling solvent for nitrocellulose, resins, 

and lacquers; as a solubilizer in organic 

synthesis; as a solvent in the production 

of plastic resins and compounds, rubber 

chemicals; as a solvent for conductive 

printing ink; in the production of 

printed circuit etchants; in the 

preparation of and reaction with 

Grignard reagents; in metal extractions; 

as a solvent in pharmaceutical 

syntheses; in the production of coatings; 

and as a gas scrubbing liquid (Ref. 6, pp. 

14–19). 

The chemicals listed in Table 2, 

pentaethylene glycol dibutyl ether and 

butyltriglyme, have no known uses (Ref. 

6, p. 19). 

2. Potential for Other Ongoing Uses of 

Glymes. In order to ascertain if there are 

any ongoing uses of these glymes, EPA 

used information submitted under the 

IUR rule, contacted manufacturers, 

searched business periodicals, and 

searched other available sources. In 

some instances, EPA could confirm the 

existence of an ongoing use in a 

consumer product from the information 

reviewed. In other instances, the results 

of EPA’s search were unclear, and EPA 

could not confirm whether certain 

reported consumer product uses were 

actual ongoing uses. 

Therefore, EPA is requesting public 

comment on whether any of the 

additional unconfirmed uses listed in 

this unit are actual, ongoing uses in a 

consumer product, and whether there 

are any other ongoing uses in a 

consumer product of the chemicals 

listed in Table 1. For pentaethylene 

glycol dibutyl ether and butyltriglyme, 

EPA is requesting public comment on 

whether there are any ongoing uses at 

all (consumer or industrial). EPA does 

not anticipate that it will add additional 

exclusions to the final rule, beyond 

those listed in Table 1, except where 

public comment adequately 

substantiates the existence of a claimed 

additional ongoing use. 

TABLE 3—REPORTED CONSUMER USES OF GLYMES THAT ARE UNCONFIRMED

Common name Additional unconfirmed reports of use 

(In addition to any confirmed ongoing consumer uses listed in table 1) 

Monoglyme ...................................... Treat aluminum surfaces to ensure surfaces are less reactive, inner and outer layer etching of printed circuit board manufacturing. 

Diglyme ........................................... Component in automotive care products, a component of brake fluid, a component in paints and coatings, 

and a component in adhesives and sealants. 

Ethyldiglyme .................................... Component in paint and paint varnishes, use in coatings manufacturing, use in adhesives manufacturing, 

and as a solvent in printing. 

Triglyme .......................................... None in consumer products. 

Butyldiglyme .................................... None in consumer products. 

Tetraethylene glycol dibutyl ether ... Use as an ingredient in consumer brake fluid. 

Tetraglyme ...................................... Use in fabrics, textiles and apparel. 

Ethylglyme ....................................... Use as a solvent in consumer paint production, use as an adhesive solvent, use as a polycarbonate swelling agent, use in consumer polishes and related products. 

Tetraethylene glycol diethyl ether ... Use as an ingredient in consumer brake fluid. 

Pentaethylene glycol diethyl ether .. Use as an ingredient in consumer brake fluid, use in the soldering of electronic circuit boards. 

Polyglyme ........................................ Use in adhesive removers, use in fragrance production, use in anti-fog compounds, use in brake fluid, use 

in automotive care products, and use in paper products. 

Polyethylene glycol dibutyl ether .... Use in the production of gel laundry detergents. 

Pentaethylene glycol dibutyl ether .. None. 

Butyltriglyme .................................... None. 

B. What are the estimated production 

levels of these chemicals? 

The 2006 IUR regulation required 

manufacturers and importers of certain 

chemical substances included on the 

TSCA Chemical Substance Inventory to 

report site and manufacturing 

information for chemicals manufactured 

(including imported) in amounts of 

25,000 pounds or greater at a single site. 

For monoglyme and diglyme, EPA 

expects that current production levels 

will continue. For triglyme and 

ethylglyme, predicting future 

production is infeasible, although 

ethylglyme production appears to be 

increasing. For ethyldiglyme, 

butyldiglyme, and tetraglyme, EPA 

expects that production will remain at 

the previous levels. Production of 

pentaethylene glycol diethyl ether 

appears to be steadily increasing. For 

polyglyme, EPA expects that production 

will continue to decrease and/or remain 

the same. For tetraethylene glycol 

dibutyl ether, tetraethylene glycol 

diethyl ether, polyethylene glycol 

dibutyl ether, pentaethylene glycol 

dibutyl ether, and butyltriglyme, EPA 

expects that production of these 

chemical substances, if any, will remain 

below reporting levels. Previous IUR 

reporting rules required that chemicals 

produced at amounts of 10,000 pounds 

or greater be reported. Table 3 

summarizes 2006 and prior year IUR 

data for the 14 glymes. The projected 

trends are based on the IUR data from 

1986–2006. The projections may not be 

precise since the IUR data does not 

reflect 100% of chemicals and their 

production and requirements for 

reporting have varied over time. 


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TABLE 4—PRODUCTION REPORTING AMOUNTS TO IUR 1986–2006 (REF. 6) 

Common name 2006 IUR reporting Prior IUR reporting 

Monoglyme ......................................................................... >1 million (M)–<10M lbs ..................... 1986: >10 thousand (K)–<500K lbs. 

1990–2002: >1M–<10M lbs. each year. 

Diglyme .............................................................................. >1M–<10M lbs .................................... 1986–2002: >1M–<10M lbs. each year. 

Ethyldiglyme ....................................................................... >10K–<500K lbs ................................. 1986–2002: >10K–<500K lbs. each year. 

Triglyme .............................................................................. No report ............................................. 1994–2002: >10K–<500K lbs. each year. 

Butyldiglyme ....................................................................... >10K–<500K lbs ................................. 1990–2002: >10K–<500K lbs. each year. 

Tetraethylene glycol dibutyl ether ...................................... No report ............................................. No reports 1986–2002. 

Tetraglyme ......................................................................... >10K–<500K lbs ................................. 1986–2002: >10K–<500K lbs. each year. 

Ethylglyme .......................................................................... >10K–<500K lbs ................................. 1986–2002: No reports. 

Tetraethylene glycol diethyl ether ...................................... No report ............................................. No reports 1986–2002. 

Pentaethylene glycol diethyl ether ..................................... >1M–<10M lbs .................................... 1986 & 1990: >10K–<500K lbs. each year. 

1994: No report. 

1998: >500K–<1M lbs. 

2002: >1M–<10M lbs. 

Polyglyme ........................................................................... 10–500K .............................................. 1986: >1M–<10M lbs. 

1994: No report. 

1998, 2002: >10K–<500K lbs. each year. 

Polyethylene glycol dibutyl ether ....................................... No report ............................................. No reports 1986–2002. 

Pentaethylene glycol dibutyl ether ..................................... No report ............................................. No reports 1986–2002. 

Butyltriglyme ....................................................................... No report ............................................. No reports 1986–2002. 

C. What are the potential routes and 

sources of exposure for these chemicals? 

The following are summaries of the 

potential routes and sources of exposure 

for these chemicals considering ongoing 

current uses. More detailed information 

can be found in the Exposure 

Characterization documents for 

monoglyme and diglyme (Refs. 1, 2) and 

in the description of ethylglyme in the 

Hazardous Substances Data Bank (Ref. 

7). 

1. Potential exposures to the 

environment, consumers, and general 

population. The exposures described in 

this unit reflect the actual and/or 

potential indirect exposures to the 

environment, consumers, and the 

general population resulting from 

ongoing industrial and commercial uses 

of these glymes. Consumer uses, 

however, also potentially allow for the 

direct exposure to skin from product 

handling and more immediate 

inhalation exposures resulting from 

proximity to the product. However, 

little to no data is available for those 

types of use scenarios. 

Monoglyme, diglyme, ethyldiglyme, 

triglyme, butyldiglyme, and ethylglyme 

are included in the category of 

chemicals reported as ‘‘certain glycol 

ethers’’ under the ID number N230 in 

the Toxics Release Inventory (TRI) (Ref. 

8). The total release reported to the TRI 

in 2007 from all reporting sites was 

18,476,420 pounds. This total includes 

air releases of 16,416,033 pounds from 

on-site fugitive and point sources, in 

addition to on-site water releases of 

87,035 pounds. Most of the remaining 

volume of release was deep-well 

injected, sent to land treatment, 

transferred for energy recovery or 

transferred to a Publicly Owned 

Treatment Works (POTW). Release 

information about the individual glymes 

within the larger glycol ether category is 

not known (Ref. 9). Manufacturers, 

importers, or processors are required to 

report releases of chemicals on the TRI 

when total manufacturing, imports or 

processing by a facility equals 25,000 

pounds/year for the chemicals 

combined. 

Ethylglyme was found in the US EPA 

Office of Water Storage and Retrieval 

(STORET) database indicating potential 

environmental exposure since this 

chemical substance was found in 

ground water and/or surface water (Ref. 

9). 

Monitoring data indicate that the 

general population may be exposed to 

diglyme and ethyldiglyme via 

inhalation of vehicle exhaust and 

ingestion of contaminated drinking 

water (Refs. 10 and 11). Diglyme was 

listed as a contaminant found in 

drinking water (Ref. 10). 

Diglyme has been detected in diluted 

vehicle exhaust from a light-duty truck 

using different fuel types (Ref. 10). 

Industrial manufacture and 

processing may result in the release of 

glymes to the environment through 

various waste streams (Ref. 10). 

Diglyme, ethyldiglyme, and ethylglyme 

have been found at measurable 

concentrations in industrial wastewater 

treatment systems (Refs. 10, 11, and 7). 

Wastewater treatment systems discharge 

to either surface waters or publicly 

owned treatment works. Either of these 

two discharge options could result in 

exposures for the general population 

and the environment to these chemicals. 

Ethyldiglyme has been qualitatively 

detected in drinking water from 

Cincinnati, OH; in ground water from 

the Hipps Road Landfill in Jacksonville, 

FL; in trench leachates from Maxey 

Flats, KY and West Valley, NY low-level 

radioactive waste disposal sites and in 

advanced waste treatment water from 

Lake Tahoe, CA, Pomona, CA, and Blue 

Plains, Washington, DC (Ref. 11). 

Ethylglyme has been detected in 

western Cleveland, OH wastewater 

influents at 140 μg/L and it was 

identified in Chicago Central water 

works water (treated and untreated) at 

2 μg/L (Ref. 7). 

Monitoring data for ethylglyme 

indicates that the general population 

may be exposed to the chemical 

substance through releases from 

manufacturing facilities. The general 

population can then be exposed via 

inhalation of ambient air, ingestion of 

drinking water, and dermal contact with 

these substances and other products 

containing these chemicals. Evidence of 

releases from industrial manufacturing 

and processing is demonstrated by 

concentrations of 400 milligrams per 

liter (mg/L) of diglyme which have been 

found in activated sludge from the 

waste treatment facility of the industry 

producing the chemical substance 

(Ref. 7). 

For the remaining chemicals in Table 

1 or Table 2, little or no release 

information was found. 

EPA’s Source Ranking Databank (Ref. 

12) shows metal polish and polishing 

cloths and papers as containing 

ethylglyme. Most of the entries in this 

databank for consumer products are 

from the late 1990s and therefore may 

not still be current. If ethylglyme is still 


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found in these products, however, there 

is potential that consumers and children 

might be exposed to this chemical 

substance from these consumer 

products. Furthermore, production of 

ethylglyme appears to be increasing. 

Based on IUR data and 

communications with manufacturers, 

EPA believes that monoglyme is used as 

a component of lithium batteries and 

diglyme is used in printing inks, both of 

which are consumer applications of 

monoglyme. It is believed that disposal 

of the lithium batteries containing 

monoglyme and paper with printing 

inks containing diglyme could present 

the potential for release of these 

chemicals to environmental media and 

subsequent exposure to humans and 

ecological receptors. 

2. Potential occupational exposure. 

Occupational exposure to these 

chemicals may occur through inhalation 

and dermal contact at workplaces where 

the chemicals are produced or used. 

Monoglyme, diglyme, ethylglyme, 

ethyldiglyme, triglyme, and 

tetraethylene glycol diethyl ether all 

have vapor pressures high enough to 

potentially result in significant 

exposures to workers if they are near the 

chemical substance (Refs. 1, 2, 9, and 

13). Based on IUR data, ethyldiglyme, 

butyldiglyme, tetraglyme, pentaethylene 

glycol diethyl ether, and polyglyme are 

manufactured in liquid forms, and 

worker exposures through dermal 

contact are possible (Ref. 13). 

These chemicals do not have 

Occupational Safety and Health 

Administration (OSHA) Permissible 

Exposure Limits (PELs) (Refs. 1, 2, and 

9). Ferro Corporation, in their 

publications, recommended a Threshold 

Limit Value (TLV) for glycol ethers of 5 

parts per million (ppm) (Time Weighted 

Average (TWA)) with a Short Term 

Exposure Limit (STEL) of 25 ppm. The 

15-minute STEL should not be achieved 

more than 4 times in 8 hours. For 

women of child-bearing potential, Ferro 

recommended a TLV of 1 ppm with a 

STEL of 5 ppm (Ref. 14). 

Based on the 2006 IUR reports, the 

maximum total number of potentially 

exposed industrial workers to 

monoglyme and ethylglyme during 

manufacturing and industrial processing 

and use is less than 100 each, and the 

maximum total number of workers 

likely to be exposed to diglyme was 

between 100 and 999 workers. There 

may, however, be additional potentially 

exposed industrial workers who are not 

included in these estimates since not all 

production volume may have been 

accounted for in the IUR (production 

below 25,000 pounds at a site does not 

have to be reported to the IUR), and 

commercial workers may be exposed as 

well (Refs. 1, 2, and 15). 

D. What are the potential health effects 

of these chemicals? 

The following are summaries of the 

potential health effects of these 

chemicals considering ongoing current 

uses. More detailed information can be 

found in the Hazard Characterization 

documents for monoglyme and diglyme 

(Refs. 3, 4) and in the description of 

ethylglyme in the Hazardous Substances 

Data Bank (Ref. 7). 

Toxicology studies in laboratory 

animals have shown that exposure to 

monoglyme results in hemolytic effects 

(destruction of red blood cells), and 

developmental and reproductive 

toxicity. The acute toxicity of 

monoglyme is low via oral, dermal and 

inhalation routes of exposure. 

Monoglyme’s chronic adverse health 

effects generally fall into the moderate 

to high hazard range based on the 

classification ranges used in the 

Globally Harmonized System for 

Classification and Labeling of Chemicals 

(GHS). The potential toxicity from 

repeated exposure to monoglyme was 

assessed using a major metabolite, 2- 

methoxyethanol (CASRN 109–86–4). 

Oral 90-day studies of 2- 

methoxyethanol in rats and mice 

showed testicular degeneration and 

adverse effects on the process of blood 

cell formation. The lowest observed 

adverse effect level (LOAEL) in rats was 

70 milligrams/kilograms (mg/kg)-day; 

the LOAEL in mice was 300 mg/kg-day. 

An oral prenatal developmental toxicity 

study of monoglyme in rats showed fetal 

mortality at doses as low as 60 mg/kgday, and edema at doses as low as 30 

mg/kg-day. An oral prenatal 

developmental toxicity study of 

monoglyme in mice showed reduced 

fetal body weight and increased skeletal 

defects at 250 mg/kg-day. Available data 

also suggest that monoglyme has the 

potential to be genotoxic (Ref. 3). 

Toxicology studies in laboratory 

animals have shown that exposure to 

diglyme results in hemolytic effects 

(destruction of red blood cells), and 

developmental and reproductive 

toxicity. The acute toxicity of diglyme to 

rats via the oral and inhalation routes of 

exposure is low. The chronic adverse 

health effects of diglyme generally fall 

into the moderate to high hazard range 

based on the classification ranges used 

in the GHS. The toxicity profile 

following repeated exposures to diglyme 

is similar to the profile for monoglyme. 

Rats showed testicular degeneration and 

hemolytic effects following inhalation 

exposure to diglyme for two weeks at 

concentrations as low as 0.6 mg/L-day; 

a NOAEL was not established. An 

inhalation dominant-lethal study in rats 

showed a reduced pregnancy rate at 5.5 

mg/L-day (5.5 ppm in air). An oral 

prenatal developmental toxicity study 

in mice showed effects on fetal growth 

and viability, and an increase in 

malformations at 125 mg/kg-day; the 

NOAEL was 62.5 mg/kg-day. In vitro 

gene mutation and in vivo chromosomal 

aberration tests were negative (Ref. 4). 

Toxicology studies in laboratory 

animals have shown that exposure to 

ethylglyme results in developmental 

toxicity. The acute toxicity of 

ethylglyme is low in rats. Oral prenatal 

developmental toxicity studies of 

ethylglyme in mice and rabbits showed 

a significant decrease in fetal body 

weight and viability, and a significant 

increase in malformations; the NOAEL 

for developmental toxicity was 50 mg/ 

kg-day in mice and 25 mg/kg-day in 

rabbits (Ref. 7), both falling into the high 

chronic hazard range based on the GHS. 

Based on a review of the literature, 

there is insufficient information 

available to arrive at any health effects 

related conclusions for the remaining 

chemicals in Table 1 or Table 2. 

V. Alternatives Considered for This 

SNUR 

Before proposing this SNUR, EPA 

considered promulgating a TSCA 

section 8(a) reporting rule for these 

glymes. Under a TSCA section 8(a) rule, 

EPA could, among other things, 

generally require persons to report 

information to the Agency when they 

intend to manufacture, import, or 

process a listed chemical substance for 

a specific use or any use. However, for 

these glymes, the use of TSCA section 

8(a) rather than SNUR authority would 

have several limitations. First, if EPA 

was to require reporting under TSCA 

section 8(a) instead of TSCA section 

5(a), EPA would not have the 

opportunity to review human and 

environmental hazards and exposures 

associated with the proposed significant 

new use and, if necessary, take 

immediate follow-up regulatory action 

under TSCA sections 5(e) or 5(f) to 

prohibit or limit the activity before it 

begins. In addition, EPA may not 

receive important information from 

small businesses, because such firms 

generally are exempt from TSCA section 

8(a) reporting requirements. In view of 

the level of health and environmental 

concerns about monoglyme, diglyme, 

and ethylglyme if used for the proposed 

significant new use, and the lack of 

information to be able to judge exposure 

for the remaining glymes, EPA believes 

that a TSCA section 8(a) rule for this 


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substance would not meet EPA’s 

regulatory objectives. 

VI. Applicability of Rule to Uses 

Occurring Before Effective Date of the 

Final Rule 

As discussed in the Federal Register 

of April 24, 1990 (55 FR 17376), EPA 

has decided that the intent of section 

5(a)(1)(B) of TSCA is best served by 

designating a use as a significant new 

use as of the date of publication of the 

proposed rule rather than as of the 

effective date of the final rule. If uses 

begun after publication of the proposed 

rule were considered ongoing rather 

than new, it would be difficult for EPA 

to establish SNUR notice requirements, 

because a person could defeat the SNUR 

by initiating the proposed significant 

new use before the rule became final, 

and then argue that the use was ongoing 

as of the effective date of the final rule. 

Thus, persons who begin commercial 

manufacture, import, or processing of 

the chemical substance(s) that would be 

regulated through this proposed rule, if 

finalized, would have to cease any such 

activity before the effective date of the 

rule if and when finalized. To resume 

their activities, these persons would 

have to comply with all applicable 

SNUR notice requirements and wait 

until the notice review period, 

including all extensions, expires. EPA 

has promulgated provisions to allow 

persons to comply with this SNUR 

before the effective date. If a person 

were to meet the conditions of advance 

compliance under section 721.45(h), 

that person would be considered to have 

met the requirements of the final SNUR 

for those activities. 

VII. Applicability of General Provisions 

General provisions for SNURs appear 

under 40 CFR part 721, subpart A. 

These provisions describe persons 

subject to the rule, recordkeeping 

requirements, exemptions to reporting 

requirements, and applicability of the 

rule to uses occurring before the 

effective date of the final rule. 

Provisions relating to user fees appear at 

40 CFR part 700. According to 40 CFR 

721.1(c), persons subject to SNURs must 

comply with the same notice 

requirements and EPA regulatory 

procedures as submitters of 

Premanufacture Notices (PMNs) under 

TSCA section 5(a)(1)(A). In particular, 

these requirements include the 

information submissions requirements 

of TSCA section 5(b) and 5(d)(1), the 

exemptions authorized by TSCA section 

5(h)(1), (h)(2), (h)(3), and (h)(5), and the 

regulations at 40 CFR part 720. Once 

EPA receives a SNUN, EPA may take 

regulatory action under TSCA section 

5(e), 5(f), 6 or 7 to control the activities 

on which it has received the SNUN. If 

EPA does not take action, EPA is 

required under TSCA section 5(g) to 

explain in the Federal Register its 

reasons for not taking action. 

Persons who export or intend to 

export a chemical substance identified 

in a proposed or final SNUR are subject 

to the export notification provisions of 

TSCA section 12(b). The regulations that 

interpret TSCA section 12(b) appear at 

40 CFR part 707, subpart D. Persons 

who import a chemical substance 

identified in a final SNUR are subject to 

the TSCA section 13 import certification 

requirements, codified at 19 CFR 12.118 

through 12.127; see also 19 CFR 127.28. 

Such persons must certify that the 

shipment of the chemical substance 

complies with all applicable rules and 

orders under TSCA, including any 

SNUR requirements. The EPA policy in 

support of import certification appears 

at 40 CFR part 707, subpart B. 

VIII. Test Data and Other Information 

EPA recognizes that TSCA section 5 

does not require developing any 

particular test data before submission of 

a SNUN. There are two exceptions: i. 

development of test data is required 

where the chemical substance subject to 

the SNUR is also subject to a test rule 

under TSCA section 4 (see TSCA 

section 5(b)(1)); and ii. development of 

test data may be necessary where the 

chemical substance has been listed 

under TSCA section 5(b)(4) (see TSCA 

section 5(b)(2)). In the absence of a 

section 4 test rule or a section 5(b)(4) 

listing covering the chemical substance, 

persons are required only to submit test 

data in their possession or control and 

to describe any other data known to or 

reasonably ascertainable by them (15 

U.S.C. 2604(d); 40 CFR 721.25, and 40 

CFR 720.50). However, as a general 

matter, EPA recommends that SNUN 

submitters include data that would 

permit a reasoned evaluation of risks 

posed by the chemical substance during 

its manufacture, import, processing, use, 

distribution in commerce, or disposal. 

EPA encourages persons to consult with 

the Agency before submitting a SNUN. 

As part of this optional pre-notice 

consultation, EPA would discuss 

specific data it believes may be useful 

in evaluating a significant new use. 

SNUNs submitted for significant new 

uses without any test data may increase 

the likelihood that EPA will take action 

under TSCA section 5(e) to prohibit or 

limit activities associated with this 

chemical. 

SNUN submitters should be aware 

that EPA will be better able to evaluate 

SNUNs that provide detailed 

information on: 

1. Human exposure and 

environmental releases that may result 

from the significant new uses of the 

chemical substances. 

2. Potential benefits of the chemical 

substances. 

3. Information on risks posed by the 

chemical substances compared to risks 

posed by potential substitutes. 

IX. SNUN Submissions 

EPA recommends that submitters 

consult with the Agency prior to 

submitting a SNUN to discuss what data 

may be useful in evaluating a significant 

new use. Discussions with the Agency 

prior to submission can afford ample 

time to conduct any tests that might be 

helpful in evaluating risks posed by the 

substance. According to 40 CFR 

721.1(c), persons submitting a SNUN 

must comply with the same notice 

requirements and EPA regulatory 

procedures as persons submitting a 

PMN, including submission of test data 

on health and environmental effects as 

described in 40 CFR 720.50. SNUNs 

must be submitted to EPA, on EPA Form 

No. 7710–25 in accordance with the 

procedures set forth in 40 CFR 721.25 

and 720.40. 

Readers are reminded that EPA 

published a final rule at 75 FR 773 on 

January 6, 2010, (FRL–8794–5) that 

established standards and requirements 

for the use of the electronic-PMN 

(e-PMN) software and EPA’s Central 

Data Exchange (CDX) to electronically 

submit these notices. The Agency is 

introducing electronic reporting via 

CDX using the e-PMN in three phases 

over a two-year period. The effective 

date of the rule was April 6, 2010. 

During the first year following the 

effective date of the final rule, 

submissions will be permitted via CDX, 

optical disc, or paper. After April 6, 

2011, paper submissions will no longer 

be accepted. After April 6, 2012, all 

submissions will be required to be 

submitted electronically via CDX. 

Regardless of the delivery method, after 

April 6, 2010, EPA requires that all 

submissions be generated using the new 

e-PMN software. For additional 

information and instructions go to: 

http://www.epa.gov/opptintr/

newchems//epmn/epmn-index.htm. 

Until April 6, 2012, SNUNs may still be 

mailed to the Environmental Protection 

Agency, OPPT Document Control Office 

(7407M), 1200 Pennsylvania Avenue, 

NW., Washington, DC 20460–0001. 


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X. Economic Analysis 

A. SNUNs 

EPA has evaluated the potential costs 

of establishing SNUR reporting 

requirements for potential 

manufacturers, importers, and 

processors of the chemical substances 

included in this proposed rule. While 

most businesses are subject to a 

$2,500 user fee required by 40 CFR 

700.45(b)(2)(iii), small businesses with 

annual sales of less than $40 million 

when combined with those of the parent 

company (if any) are subject to a 

reduced user fee of $100 (40 CFR 

700.45(b)(1)). The costs of submission of 

SNUNs will not be incurred by any 

company unless a company decides to 

pursue a significant new use as defined 

in this proposed SNUR. Furthermore, 

EPA believes that the expense of 

submitting a notice (approximately 

$6,000 plus the user fee) is unlikely to 

discourage innovations of high potential 

value. EPA’s complete economic 

analysis is available in the public docket 

for this proposed rule (Ref. 16). 

B. Export Notification 

Under section 12(b) of TSCA and the 

implementing regulations at 40 CFR part 

707, subpart D, exporters must notify 

EPA if they export or intend to export 

a chemical substance or mixture for 

which, among other things, a rule has 

been proposed or promulgated under 

TSCA section 5. For persons exporting 

a substance the subject of a SNUR, a 

one-time notice must be provided for 

the first export or intended export to a 

particular country. EPA estimates the 

one-time cost to be approximately $937 

per exporter including mailing costs. 

The total costs of export notification 

will vary by chemical, depending on the 

number of required notifications (i.e., 

the number of countries to which the 

chemical substance is exported). 

Because EPA is unable to make an 

estimate of the likely number of export 

notifications for the chemicals covered 

in this proposed SNUR, a total export 

notification cost is not available. 

XI. Request for Public Comment 

EPA welcomes comment on all 

aspects of this proposed rule. In 

addition, EPA is particularly interested 

in receiving stakeholder input on a 

number of issues that were identified for 

public comment earlier in this proposed 

rule. Please provide comments on the 

following issues: 

1. Scope of the chemical substances to 

be subject to this SNUR. While hazard 

data are only currently available for 3 of 

the 14 chemical substances in the 

glymes chemical category identified in 

this proposed rule (see Unit IV.D.), EPA 

is proposing to designate significant 

new uses for all 14 chemical substances 

listed in Tables 1 and 2 in Unit III.A. on 

the basis of the available information. 

As discussed in Unit III.A. of this 

document, EPA believes that the 

chemicals are sufficiently similar such 

that it is appropriate, for purposes of 

this SNUR and consistent with TSCA 

section 26(c), to act on them together. 

However, EPA would be interested in 

hearing whether any of the chemical 

substances included in the category are 

sufficiently dissimilar from the rest such 

that they should be removed from the 

category, or whether any additional 

chemical substances are sufficiently 

similar such that they should be added 

to the category. 

2. Ongoing uses. EPA solicits 

comment on whether any of the 

additional unconfirmed uses listed in 

this proposed rule are actual ongoing 

uses in a consumer product, and 

whether there are any other ongoing 

uses in a consumer product of the 

chemicals listed in Table 1 in Unit III.A. 

For pentaethylene glycol dibutyl ether 

and butyltriglyme, EPA is soliciting 

comment on whether there are any 

ongoing uses at all (consumer or 

industrial). In providing comments on 

ongoing uses, it would be most helpful 

if you provide sufficient information for 

EPA to adequately substantiate the 

existence of a claimed additional 

ongoing use. 

XII. References 

The following is a list of the 

documents that are specifically 

referenced in this proposed rule and 

placed in the public docket that was 

established under Docket ID No. EPA– 

HQ–OPPT–2009–0767. The docket 

includes information considered by EPA 

in developing this proposed rule. In 

addition, interested parties should 

consult documents that are referenced 

in the documents that EPA has placed 

in the public docket, regardless of 

whether these referenced documents are 

physically located in the public docket. 

1. US EPA. Screening-Level Exposure 

Characterization of High Production 

Volume Chemicals: 1,2- 

Dimethoxyethane 

(CAS No. 110–71–4), [9th CI Name: 

Ethane, 1,2-dimethoxy-]. March 2008, 

page 21. http://www.epa.gov/chemrtk/

hpvis/rbp/Monoglyme.110714.Web.

SupportDocs.31408.pdf. 

2. US EPA. Screening-Level Exposure 

Characterization of High Production 

Volume Chemicals: Diglyme 

(CAS No. 111–96–6), [9th CI Name: 

Bis(2-methoxyethyl) Ether]. March 2008, 

page 16. http://www.epa.gov/chemrtk/

hpvis/rbp/Diglyme.111966.Web.Support

Docs.031808.pdf. 

3. US EPA. Screening-Level Hazard 

Characterization of High Production 

Volume Chemicals: 1,2- 

Dimethoxyethane (CAS No. 110–71–4), 

[9th CI Name: Ethane, 1,2-dimethoxy-]. 

February 2008, page 6. http:// 

www.epa.gov/chemrtk/hpvis/rbp/

Monoglyme.110714.Web.Support

Docs.31408.pdf. 

4. US EPA. Screening-Level Hazard 

Characterization of High Production 

Volume Chemicals: Diglyme (CAS No. 

111–96–6), [9th CI Name: Bis(2- 

methoxyethyl) Ether]. February 2008, 

page 6. http://www.epa.gov/chemrtk/

hpvis/rbp/Diglyme.111966.Web.Support

Docs.031808.pdf 

5. US EPA. ‘‘2-ethoxyethanol, 2- 

ethoxyethanol acetate, 2- 

methoxyethanol, and 2-methoxyethanol 

acetate; Significant New Use Rule.’’ 70 

FR 71401. November 29, 2005. 

6. Wilson, Kimberly; Tome, Alice; and 

Narayan, Tulika, Abt Associates, Inc. 

‘‘Memorandum to EPA, Nishkam 

Agarwal, ‘Actual and Potential Uses of 

Fourteen Selected Glymes.’ ’’ September 

9, 2009. 

7. Hazardous Substances Data Bank (HSDB). 

Entry for Ethylene glycol diethyl ether, 

CASRN 629–14–1. Accessed on October 

30, 2009. http://toxnet.nlm.nih.gov. 

8. US EPA. TRI Web site. http:// 

www.epa.gov/ttn/atw/glycol2000.pdf. 

9. US EPA. Exposure Characterization for 

Ethylglyme. November 6, 2009. 

10. Hazardous Substances Data Bank (HSDB). 

Hazardous Substances Data Bank. Entry 

for diglyme. Accessed October 30, 2009. 

http://toxnet.nlm.nih.gov. 

11. Hazardous Substances Data Bank (HSDB). 

Entry for CASRN 112–36–7. Accessed on 

October 28, 2009. http:// 

toxnet.nlm.nih.gov. 

12. The Source Ranking Database is an EPA 

database that performs a systematic 

screening-level review of over 12,000 

potential indoor pollution sources to 

identify high-priority product and 

material categories for further evaluation. 

It can also identify the products that 

have contained a specific chemical. May 

1997. http://www.epa.gov/oppt/

exposure/pubs/srd_apdx.pdf. 

13. US EPA. Physical-Chemical Properties 

and Fate Characterization: Glycol Ethers. 

Washington, DC: U.S. EPA/OPPT/EETD/ 

EAB. August 2009. 

14. Ferro Corporation. 1,2-Dimethoxyethane 

US EPA HPV Challenge Program 

Submission. December 2001, pages 7–8 

of 93. 

15. US EPA. IUR database search results for 

number of workers exposed to 

ethylglyme, http://cfpub.epa.gov/ 

iursearch/ 

2006_iur_natlcheminfo.cfm?id=3975. 

Accessed on October 21, 2009. 

16. US EPA. Economic Analysis of the 

Proposed Significant New Use Rule for 

14 Glymes. Washington, DC: U.S. EPA/ 

OPPT/EETD/EPAB. January 12, 2010. 


jdjones on DSK8KYBLC1PROD with PROPOSALS-1
Federal Register / Vol. 76, No. 133 / Tuesday, July 12, 2011 / Proposed Rules 40859 

XIII. Statutory and Executive Order 

Reviews 

A. Regulatory Planning and Review 

Under Executive Order 12866, 

entitled Regulatory Planning and 

Review (58 FR 51735, October 4, 1993), 

the Office of Management and Budget 

(OMB) has designated this a ‘‘significant 

regulatory action’’ under section 3(f) of 

the Executive Order. Accordingly, this 

action was submitted to OMB for review 

under Executive Order 12866 and any 

changes made in response to OMB 

recommendations have been 

documented in the docket for this 

rulemaking as required by section 

6(a)(3)(E) of the Executive Order. 

B. Paperwork Reduction Act 

According to the Paperwork 

Reduction Act (PRA), 44 U.S.C. 3501 et 

seq., an Agency may not conduct or 

sponsor, and a person is not required to 

respond to a collection of information 

that requires OMB approval under the 

PRA, unless it has been approved by 

OMB and displays a currently valid 

OMB control number. The OMB control 

numbers for EPA’s regulations in Title 

40 of the CFR, after appearing in the 

Federal Register, are listed in 40 CFR, 

part 9, and included on the related 

collection instrument, or form, if 

applicable. The information collection 

requirements related to this action have 

already been approved by OMB 

pursuant to the PRA under OMB control 

number 2070–0038 (EPA ICR No. 1188). 

This action does not impose any burden 

requiring additional OMB approval. If 

an entity were to submit a SNUN to the 

Agency, the annual burden is estimated 

to average 110 hours per response. This 

burden estimate includes the time 

needed to review instructions, search 

existing data sources, gather and 

maintain the data needed, and 

complete, review, and submit the 

required SNUN. Send any comments 

about the accuracy of the burden 

estimate, and any suggested methods for 

minimizing respondent burden, 

including through the use of automated 

collection techniques, to the Director, 

Collection Strategies Division, Office of 

Environmental Information (2822T), 

Environmental Protection Agency, 1200 

Pennsylvania Ave., NW., Washington, 

DC 20460–0001. Please remember to 

include the OMB control number in any 

correspondence, but do not submit any 

completed forms to this address. 

C. Small Entity Impacts 

Pursuant to section 605(b) of the 

Regulatory Flexibility Act (RFA), 5 

U.S.C. 601 et seq., the Agency hereby 

certifies that this action will not have a 

significant adverse economic impact on 

a substantial number of small entities. 

Under RFA, small entities include small 

businesses, small organizations, and 

small governmental jurisdictions. For 

purposes of assessing the impacts of this 

proposed rule on small entities, small 

entity is defined in accordance with 

RFA section 601 as: 

1. A small business as defined by the 

Small Business Administration’s (SBA) 

regulations at 13 CFR 121.201. 

2. A small governmental jurisdiction 

that is a government of a city, county, 

town, school district or special district 

with a population of less than 50,000. 

3. A small organization that is any 

not-for-profit enterprise which is 

independently owned and operated and 

is not dominant in its field. 

A SNUR applies to any person 

(including small or large entities) who 

intends to engage in any activity 

described in the rule as a ‘‘significant 

new use.’’ By definition of the word 

‘‘new’’ and based on all information 

currently available to EPA, it appears 

that no small or large entities presently 

engage in such activity. Since this 

proposed SNUR would require a person 

who intends to engage in such activity 

in the future to first notify EPA by 

submitting a SNUN, no economic 

impact will occur unless someone files 

a SNUN to pursue a significant new use 

in the future or forgoes profits by 

avoiding or delaying the significant new 

use. Although some small entities may 

decide to conduct such activities in the 

future, EPA cannot presently determine 

how many, if any, there may be. 

However, EPA’s experience to date is 

that, in response to the promulgation of 

over 1,000 SNURs, the Agency receives 

on average only 5 notices per year. Of 

those SNUNs submitted, only one 

appears to be from a small entity in 

response to any SNUR. Therefore, EPA 

believes that the potential economic 

impact of complying with this SNUR is 

not expected to be significant or 

adversely impact a substantial number 

of small entities. In a SNUR that 

published as a final rule on August 8, 

1997 (62 FR 42690) (FRL–5735–4), the 

Agency presented its general 

determination that proposed and final 

SNURs are not expected to have a 

significant economic impact on a 

substantial number of small entities, 

which was provided to the Chief 

Counsel for Advocacy of the Small 

Business Administration. 

D. Unfunded Mandates Reform Act 

Based on EPA’s experience with 

proposing and finalizing SNURs, State, 

local, and Tribal governments have not 

been impacted by these rulemakings, 

and EPA does not have any reason to 

believe that any State, local, or Tribal 

government would be impacted by this 

rulemaking. As such, EPA has 

determined that this regulatory action 

would not impose any enforceable duty, 

contain any unfunded mandate, or 

otherwise have any effect on small 

governments subject to the requirements 

of sections 202, 203, 204, or 205 of the 

Unfunded Mandates Reform Act of 1995 

(UMRA), 2 U.S.C. 1531–1538. 

E. Federalism 

This action would not have a 

substantial direct effect on States, on the 

relationship between the national 

government and the States, or on the 

distribution of power and 

responsibilities among the various 

levels of government, as specified in 

Executive Order 13132, entitled 

Federalism (64 FR 43255, August 10, 

1999). 

F. Tribal Implications 

This proposed rule would not have 

Tribal implications because it is not 

expected to have substantial direct 

effects on Indian Tribes. This proposed 

rule would not significantly or uniquely 

affect the communities of Indian Tribal 

governments, nor would it involve or 

impose any requirements that affect 

Indian Tribes. Accordingly, the 

requirements of Executive Order 13175, 

entitled Consultation and Coordination 

with Indian Tribal Governments (65 FR 

67249, November 9, 2000), do not apply 

to this proposed rule. 

G. Children’s Health Protections 

This action is not subject to Executive 

Order 13045, entitled Protection of 

Children from Environmental Health 

Risks and Safety Risks (62 FR 19885, 

April 23, 1997), because this is not an 

economically significant regulatory 

action as defined by Executive Order 

12866, and this action does not address 

environmental health or safety risks 

disproportionately affecting children. 

H. Affect on Energy Supply, 

Distribution, or Use 

This proposed rule is not subject to 

Executive Order 13211, entitled Actions 

Concerning Regulations That 

Significantly Affect Energy Supply, 

Distribution, or Use (66 FR 28355, May 

22, 2001), because this action is not 

expected to affect energy supply, 

distribution, or use. 

I. Technical Standards 

Because this action does not involve 

any technical standards, section 12(d) of 

the National Technology Transfer and 

Advancement Act of 1995 (NTTAA) (15 


jdjones on DSK8KYBLC1PROD with PROPOSALS-1
40860 Federal Register / Vol. 76, No. 133 / Tuesday, July 12, 2011 / Proposed Rules 

U.S.C. 272 note), does not apply to this 

action. 

J. Environmental Justice 

This action does not entail special 

considerations of environmental justice 

related issues as delineated by 

Executive Order 12898, entitled Federal 

Actions to Address Environmental 

Justice in Minority Populations and 

Low-Income Populations (59 FR 7629, 

February 16, 1994). 

List of Subjects in 40 CFR Part 721 

Environmental protection, Chemicals, 

Hazardous substances, Reporting and 

recordkeeping requirements. 

Dated: June 30, 2011. 

Wendy C. Hamnett, 

Director, Office of Pollution Prevention and 

Toxics. 

Therefore, it is proposed that 40 CFR 

chapter I be amended as follows: 

PART 721—[AMENDED] 

1. The authority citation for part 721 

continues to read as follows: 

Authority: 15 U.S.C. 2604, 2607, and 

2625(c). 

2. Add § 721.10229 to subpart E to 

read as follows: 

§ 721.10229 Glymes. 

Chemical substances and significant 

new uses subject to reporting. The 

chemical substances identified in Table 

1 are subject to reporting under this 

section for the significant new uses 

described in Table 1, Column 3 

‘‘Significant New Use.’’ 

TABLE 1—CHEMICALS SUBJECT TO REPORTING AND DESIGNATED SIGNIFICANT NEW USES

CAS Registry No. 

(CASRN) CA index name Significant new use 

110–71–4 ............................. Ethane, 1,2-dimethoxy- ................................................... Any use in a consumer product except in electrolyte solutions for sealed lithium batteries. 

111–96–6 ............................. Ethane, 1,1′-oxybis[2-methoxy- ....................................... Any use in a consumer product except as a solvent in 

printing inks for consumer products. 

112–36–7 ............................. Ethane, 1,1′-oxybis[2-ethoxy- .......................................... Any use in a consumer product. 

112–49–2 ............................. 2,5,8,11-Tetraoxadodecane ............................................ Any use in a consumer product except: 

—As a solvent in consumer adhesives. 

—As a component of consumer brake fluids. 

—As a component of consumer paint/graffiti removers. 

—In consumer paints. 

112–73–2 ............................. Butane, 1,1′-[oxybis(2,1-ethanediyloxy)]bis- ................... Any use in a consumer product. 

112–98–1 ............................. 5,8,11,14,17-Pentaoxaheneicosane ................................ Any use in a consumer product. 

143–24–8 ............................. 2,5,8,11,14-Pentaoxapentadecane ................................. Any use in a consumer product except: 

—As an HFC/CFC lubricant. 

—As a solubilizing agent for consumer printing 

inks. 

—As a coalescing agent in consumer paints. 

629–14–1 ............................. Ethane, 1,2-diethoxy- ...................................................... Any use in a consumer product. 

4353–28–0 ........................... 3,6,9,12,15-Pentaoxaheptadecane ................................. Any use in a consumer product. 

23601–39–0 ......................... 3,6,9,12,15,18-Hexaoxaeicosane .................................... Any use in a consumer product. 

24991–55–7 ......................... Poly(oxy-1,2-ethanediyl), .alpha.-methyl-.omega.- 

methoxy-.

Any use in a consumer product except in consumer 

paint strippers. 

31885–97–9 ......................... Poly(oxy-1,2-ethanediyl), .alpha.-butyl-.omega.-butoxy- Any use in a consumer product. 

51105–00–1 ......................... 5,8,11,14,17,20-Hexaoxatetracosane ............................. Any use. 

63512–36–7 ......................... 5,8,11,14-Tetraoxaoctadecane ....................................... Any use. 

[FR Doc. 2011–17084 Filed 7–11–11; 8:45 am] 

BILLING CODE 6560–50–P 

DEPARTMENT OF TRANSPORTATION 

National Highway Traffic Safety 

Administration 

49 CFR Part 571 

[Docket No. NHTSA–2011–0100] 

Notice of Intent To Prepare an 

Environmental Assessment for 

Pedestrian Safety Enhancement Act of 

2010 Rulemaking 

AGENCY: National Highway Traffic 

Safety Administration (NHTSA), 

Department of Transportation (DOT). 

ACTION: Notice of intent; request for 

scoping comments. 

SUMMARY: Pursuant to the National 

Environmental Policy Act (NEPA), 

NHTSA plans to analyze the potential 

environmental impacts of the agency’s 

rulemaking to implement the Pedestrian 

Safety Enhancement Act of 2010. The 

Pedestrian Safety Enhancement Act 

mandates a rulemaking to establish a 

standard requiring electric and hybrid 

vehicles to be equipped with a 

pedestrian alert sound system that 

would activate in certain vehicle 

operating conditions to aid visuallyimpaired and other pedestrians in 

detecting the presence, direction, 

location, and operation of those 

vehicles. 

Under NEPA, once an agency 

determines the purpose and need of the 

proposed federal action, it engages in 

scoping. This is the process by which 

the scope of the issues and the 

alternatives to be examined are 

determined. This notice initiates the 

scoping process by inviting comments 

from Federal, State, and local agencies, 

Indian Tribes, and the public to help 

identify the environmental issues and 

reasonable alternatives to be examined 

under NEPA. This notice also provides 

guidance for participating in the scoping 

process and additional information 

about the alternatives NHTSA expects to 

consider in its NEPA analysis. 

DATES: The scoping process will 

culminate in the preparation and 

issuance of an Environmental 

Assessment (EA), which will be made 

available for public comment. To ensure 

that NHTSA has an opportunity to 

consider scoping comments fully and to 


jdjones on DSK8KYBLC1PROD with PROPOSALS-1