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                            Funding & Awards
 Population Genetics of SNPs for Forensic Purposes
Note:
              This awardee has received supplemental funding. This award detail page includes information about both the original award and supplemental awards.
Award Information
Awardee
              Yale University
Award #
              2007-DN-BX-K197
Funding Category
              Continuation
Location
                    New Haven, CT
Congressional District
              3
Status
              Closed
Funding First Awarded
              2007
Total funding (to date)
              $1,152,430
Original Solicitation
              NIJ FY 07 Forensic DNA Research and Development: Invited Full Proposals
Description of original award (Fiscal Year 2007, $680,516)
The objectives of the principal investigator's current NIJ grant are to develop two panels of single nucleotide polymorphisms (SNPs) for forensic work. These include a panel for individual identification that would be applicable irrespective of ethnicity, and a panel suitable for refined inference of ancestry. The work performed so far has resulted in an Individual Identification SNP (IISNP) panel of 40 SNPs that provide highly probative match probabilities. The preliminary panel of SNPs to be used for Ancestry Identification (AISNPs) consists of 93 SNPs and is a significant improvement over previous SNP panels in that it is much more robust, identifies five geographic regions, and allows good resolution into populations within some of those regions but not within other regions. Fiscal year 2007 funding will allow the principal investigator to improve these panels in order to increase their utility and facilitate their transfer into operational forensic laboratories.
ca/ncf
Supplemental Award 1 (Fiscal Year 2009, $471,914)
The objectives of 2007-DN-BX-K197 are to develop two panels of single nucleotide polymorphisms (SNPs) for forensic work: a panel for individual identification that would be applicable irrespective of ethnicity, and a panel suitable for refined inference of ancestry. The individual identification SNP panel (called the IISNP panel) has been completed. The goal of the continuation is to finalize an optimized panel of SNPs that will allow law enforcement investigators to accurately estimate the ancestral origins of an unknown individual. The final ancestral Identification SNP panel (called the AISNP panel) will be made public immediately upon finalization with all associated allele frequencies.
ca/ncf


  
Grant-Funded Publications
        
                      Defining a Face: What Can DNA Phenotyping Really Tell Us About an Unknown Sample?
                  Current Sequencing Technology Makes Microhaplotypes a Powerful New Type of Genetic Marker for Forensics
                  Expanding Data and Resources for Forensic Use of SNPs in Individual Identification
                  A global view of the OCA2-HERC2 region and pigmentation
                  Exploring genomic structure differences and similarities between the Greek and European HapMap populations: implications for association studies
                  First All-in-One Diagnostic Tool for DNA Intelligence: Genome-wide Inference of Bio-Geographic Ancestry Appearance Relatedness and Sex with the Identitas v1 Forensic Chip
                  Introducing the Forensic Research/Reference on Genetics Knowledge Base FROG-kb
                  Mini-haplotypes as lineage informative SNPs (LISNPs) and ancestry inference SNPs (AISNPs)
                  Mini-haplotypes as lineage informative SNPs and ancestry inference SNPs
                  Population Genetics of SNPs for Forensic Purposes (Updated)
                  Analyses of a set of 128 ancestry informative SNPs (AISNPs) in a global set of 119 population samples
                  Hunter-gatherer genomic diversity suggests a southern African origin for modern humans
                  Selecting SNPs to identify ancestry
                  Selection on the human bitter taste gene, TAS2R16, in Eurasian populations
                  SNPs and haplotypes in Native American populations
                  SNPs for a universal individual identification panel
                  The complex global pattern of genetic variation and linkage disequilibrium at Catechol-O-methyl transferase
                  Global variation in CYP2C8 - CYP2C9 functional haplotypes
                  Low allele frequency of ADH1B*47His in West China and different ADH1B haplotypes in Western and Eastern Asia
                  Multiplexed SNP detection panels for human identification
                  Refined Geographic Distribution of the Oriental ALDH2*504Lys (nee 487Lys) Variant
                  Ethnic Related Selection for an ADH Class I Variant within East Asia
                  Report on ISFG SNP Panel Discussion
                  Candidate SNPs for a Universal Individual Identification Panel

  
Date Created: September 5, 2007
    
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