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UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549





FORM 10-Q





(Mark One)

|x | Quarterly report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934:
|- | ----------------------------------------------------------------------------------------

For the quarterly period ended March 31, 2008

OR



| ̈ | Transition report pursuant to Section 13 or 15(d) of the Securities Exchange Act of 1934:
|- | -----------------------------------------------------------------------------------------

For the transition period from              to

Commission file number:





Targanta Therapeutics Corporation

(Exact Name of Registrant as Specified in
Its Charter)







|                                                               |  |                                     
|-------------------------------------------------------------- |  | ------------------------------------
|Delaware                                                       |  | 20-3971077                          
|(State or Other Jurisdiction of Incorporation or Organization) |  | (I.R.S. Employer Identification No.)

222 Third Street, Suite 2300, Cambridge, Massachusetts 02142-1122

(Address of Principal Executive Offices) (Zip Code)

(617) 577-9020

(Registrants Telephone Number, Including Area Code)





Indicate by check mark whether the registrant:(1) has filed all reports required to be filed by Section 13 or 15(d) of the Securities
Exchange Act of 1934 during the preceding 12 months (or for such shorter period that the registrant was required to file such reports), and (2) has been subject to such filing requirements for the past
90 days.    Yes  x    No   ̈

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, or a non-accelerated filer. See definition of accelerated filer and large accelerated filer in Rule 12b-2
of the Exchange Act.

Large accelerated filer   ̈    Accelerated
filer   ̈    Non-accelerated filer  x    Smaller reporting company   ̈

Indicate by check mark whether the registrant is a shell company (as defined in Rule 12b-2 of the Exchange Act).   ̈    Yes  x    No

As of
May 9, 2008, there were 20,970,194 shares of the Registrants common stock outstanding.









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TARGANTA THERAPEUTICS CORPORATION

QUARTERLY REPORT

ON FORM 10-Q

INDEX



|                             |  |                                                                                                                                                                                           |  |     
|---------------------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------- |  | ----
|                             |  |                                                                                                                                                                                           |  | Page
|PART 1 FINANCIAL INFORMATION |  |                                                                                                                                                                                          
|Item 1.                      |  | Financial Statements (Unaudited)                                                                                                                                                          |  | 3   
|                             |  | Condensed Consolidated Balance Sheets as of March 31, 2008 and December 31, 2007                                                                                                          |  | 4   
|                             |  | Condensed Consolidated Statements of Operations for the Three Months Ended March 31, 2008 and 2007 and the cumulative period from May 20, 1997 (date of inception) through March 31, 2008 |  | 5   
|                             |  | Condensed Consolidated Statements of Cash Flows for the Three Months Ended March 31, 2008 and 2007 and the cumulative period from May 20, 1997 (date of inception) through March 31, 2008 |  | 6   
|                             |  | Notes to Condensed Consolidated Financial Statements                                                                                                                                      |  | 8   
|Item 2.                      |  | Managements Discussion and Analysis of Financial Condition and Results of Operations                                                                                                     |  | 16  
|Item 3.                      |  | Quantitative and Qualitative Disclosures about Market Risk                                                                                                                                |  | 21  
|Item 4.                      |  | Controls and Procedures                                                                                                                                                                   |  | 22  
|                             | 
|PART II. OTHER INFORMATION   |  |                                                                                                                                                                                          
|Item 1.                      |  | Legal Proceedings                                                                                                                                                                         |  | 23  
|Item 1A.                     |  | Risk Factors                                                                                                                                                                              |  | 23  
|Item 2.                      |  | Unregistered Sales of Equity Securities and Use of Proceeds                                                                                                                               |  | 43  
|Item 3.                      |  | Defaults Upon Senior Securities                                                                                                                                                           |  | 43  
|Item 4.                      |  | Submission of Matters to a Vote of Security Holders                                                                                                                                       |  | 43  
|Item 5.                      |  | Other Information                                                                                                                                                                         |  | 43  
|Item 6.                      |  | Exhibits                                                                                                                                                                                  |  | 43  
|                             | 
|SIGNATURES                   |  | 44                                                                                                                                                                                       



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PART I. FINANCIAL INFORMATION

FORWARD-LOOKING STATEMENTS

This Quarterly Report on Form 10-Q contains forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995 that
involve risks and uncertainties, as well as assumptions that, if they never materialize or prove incorrect, could cause the results of Targanta Therapeutics Corporation to differ materially from those expressed or implied by such forward-looking
statements. All statements other than statements of historical fact are statements that could be deemed forward-looking statements, including any projections of financing needs, revenue, expenses, earnings or losses from operations, or other
financial items; any statements of the plans, strategies and objectives of management for future operations, any statements concerning product research, development and commercialization plans and timelines; any statements regarding safety and
efficacy of product candidates, any statements of expectation or belief; and any statements of assumptions underlying any of the foregoing. In addition, forward looking statements may contain the words believe, anticipate,
expect, estimate, intend, plan, project, will be, will continue, will result, seek, could, may, might, or any
variations of such words or other words with similar meanings.

The risks, uncertainties and assumptions referred to above include risks
that are described in Risk Factors and elsewhere in this quarterly report and that are otherwise described from time to time in our Securities and Exchange Commission reports filed after this report.

The forward-looking statements included in this quarterly report represent our estimates as of the date of this quarterly report. We specifically
disclaim any obligation to update these forward-looking statements in the future. These forward-looking statements should not be relied upon as representing our estimates or views as of any date subsequent to the date of this quarterly report.



|Item 1. | Financial Statements  Unaudited
|------- | --------------------------------

The
financial information set forth below should be read in conjunction with our Managements Discussion and Analysis of Financial Condition and Results of Operations appearing elsewhere in this Quarterly Report on Form 10-Q.



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Targanta Therapeutics Corporation

(A development-stage company)

Condensed Consolidated Balance Sheets

(in thousands, except share and per share amounts)

(Unaudited)



|                                                                                                                                                |  |               |          |   |                  |   |          |  
|----------------------------------------------------------------------------------------------------------------------------------------------- |  | ------------- | -------- | - | ---------------- | - | -------- | -
|                                                                                                                                                |  | March 31,2008 |          |   | December 31,2007 |  
|Assets                                                                                                                                          |  |               |          |   |                  |   |          |  
|Current assets:                                                                                                                                 |  |               |          |   |                  |   |          |  
|Cash and cash equivalents                                                                                                                       |  | $             | 34,141   |   |                  | $ | 32,955   |  
|Short-term investments                                                                                                                          |  |               | 39,121   |   |                  |   | 56,798   |  
|Restricted cash                                                                                                                                 |  |               | 487      |   |                  |   | 506      |  
|Investment tax credits recoverable                                                                                                              |  |               | 436      |   |                  |   | 757      |  
|Prepaid expenses and other current assets                                                                                                       |  |               | 1,780    |   |                  |   | 1,630    |  
|                                                                                                                                                |  |               |          |   |                  |   |          |  
|Total current assets                                                                                                                            |  |               | 75,965   |   |                  |   | 92,646   |  
|Property and equipment, net                                                                                                                     |  |               | 1,267    |   |                  |   | 1,350    |  
|Deferred financing costs                                                                                                                        |  |               | 95       |   |                  |   | 103      |  
|Deposits                                                                                                                                        |  |               | 65       |   |                  |   | 50       |  
|                                                                                                                                                |  |               |          |   |                  |   |          |  
|Total assets                                                                                                                                    |  | $             | 77,392   |   |                  | $ | 94,149   |  
|                                                                                                                                                |  |               |          |   |                  |   |          |  
|                                                                                                                                                |  |              
|Liabilities and Stockholders Equity                                                                                                            |  |               |          |   |                  |   |          |  
|Current liabilities:                                                                                                                            |  |               |          |   |                  |   |          |  
|Accounts payable                                                                                                                                |  | $             | 1,651    |   |                  | $ | 718      |  
|Accrued expenses                                                                                                                                |  |               | 8,419    |   |                  |   | 5,873    |  
|Income tax payable                                                                                                                              |  |               | 665      |   |                  |   | 2,731    |  
|Current portion of deferred rent                                                                                                                |  |               | 29       |   |                  |   | 24       |  
|Current portion of long-term debt                                                                                                               |  |               | 6,591    |   |                  |   | 5,480    |  
|                                                                                                                                                |  |               |          |   |                  |   |          |  
|Total current liabilities                                                                                                                       |  |               | 17,355   |   |                  |   | 14,826   |  
|Deferred rent                                                                                                                                   |  |               | 89       |   |                  |   | 100      |  
|Other long-term liabilities                                                                                                                     |  |               | 122      |   |                  |   | 63       |  
|Long-term debt                                                                                                                                  |  |               | 12,083   |   |                  |   | 14,287   |  
|Commitments (Note 4)                                                                                                                            |  |               |          |   |                  |   |          |  
|Stockholders equity:                                                                                                                           |  |               |          |   |                  |   |          |  
|Preferred Stock, par value $0.0001; 5,000,000 shares authorized, no shares issued and outstanding                                               |  |               |         |   |                  |   |         |  
|Common stock, par value $0.0001; 35,000,000 shares authorized, 20,969,257 shares issued and outstanding at March 31, 2008 and
December 31, 2007 |  |               | 2        |   |                  |   | 2        |  
|Additional paid-in capital                                                                                                                      |  |               | 190,609  |   |                  |   | 190,137  |  
|Accumulated other comprehensive income                                                                                                          |  |               | 1,688    |   |                  |   | 1,665    |  
|Deficit accumulated during the development stage                                                                                                |  |               | (144,556 | ) |                  |   | (126,931 | )
|                                                                                                                                                |  |               |          |   |                  |   |          |  
|Total stockholders equity                                                                                                                      |  |               | 47,743   |   |                  |   | 64,873   |  
|                                                                                                                                                |  |               |          |   |                  |   |          |  
|Total liabilities and stockholders equity                                                                                                      |  | $             | 77,392   |   |                  | $ | 94,149   |  
|                                                                                                                                                |  |               |          |   |                  |   |          |  

The accompanying notes are an integral part of these consolidated financial statements.



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Targanta Therapeutics Corporation

(A development-stage company)

Condensed Consolidated Statements of Operations

(in thousands, except share and per share amounts)

(Unaudited)



|                                                                                      |  |                             |            |   |                                                                         |   |         |   |  |   |          |  
|------------------------------------------------------------------------------------- |  | --------------------------- | ---------- | - | ----------------------------------------------------------------------- | - | ------- | - |  | - | -------- | -
|                                                                                      |  | Three Months EndedMarch 31, |            |   | For the Periodfrom May 20, 1997(date of
inception)through March 31,2008 |  
|                                                                                      |  | 2008                        |            |   | 2007                                                                    |   |        
|Operating expenses                                                                    |  |                             |            |   |                                                                         |   |         |   |  |   |          |  
|Research and development (1)                                                          |  | $                           | 14,279     |   |                                                                         | $ | 5,439   |   |  | $ | 79,674   |  
|Acquired in-process research and development                                          |  |                             |           |   |                                                                         |   | 9,500   |   |  |   | 29,000   |  
|General and administrative (1)                                                        |  |                             | 3,618      |   |                                                                         |   | 1,935   |   |  |   | 24,582   |  
|                                                                                      |  |                             |            |   |                                                                         |   |         |   |  |   |          |  
|Total operating expenses                                                              |  |                             | 17,897     |   |                                                                         |   | 16,874  |   |  |   | 133,256  |  
|                                                                                      |  |                             |            |   |                                                                         |   |         |   |  |   |          |  
|Other income (expense)                                                                |  |                             |            |   |                                                                         |   |         |   |  |   |          |  
|Interest income                                                                       |  |                             | 868        |   |                                                                         |   | 458     |   |  |   | 4,325    |  
|Interest expense                                                                      |  |                             | (643       | ) |                                                                         |   | (2,210  | ) |  |   | (19,758  | )
|Foreign exchange loss                                                                 |  |                             | (19        | ) |                                                                         |   | (64     | ) |  |   | (1,953   | )
|Gain on disposal of property and equipment                                            |  |                             |           |   |                                                                         |   |        |   |  |   | 47       |  
|                                                                                      |  |                             |            |   |                                                                         |   |         |   |  |   |          |  
|Other income (expense), net                                                           |  |                             | 206        |   |                                                                         |   | (1,816  | ) |  |   | (17,339  | )
|                                                                                      |  |                             |            |   |                                                                         |   |         |   |  |   |          |  
|Loss before income tax benefit (expense)                                              |  |                             | (17,691    | ) |                                                                         |   | (18,690 | ) |  |   | (150,595 | )
|Income tax benefit (expense)                                                          |  |                             | 66         |   |                                                                         |   | (29     | ) |  |   | 6,039    |  
|                                                                                      |  |                             |            |   |                                                                         |   |         |   |  |   |          |  
|Net loss                                                                              |  | $                           | (17,625    | ) |                                                                         | $ | (18,719 | ) |  | $ | (144,556 | )
|                                                                                      |  |                             |            |   |                                                                         |   |         |   |  |   |          |  
|Net loss per sharebasic and diluted                                                  |  | $                           | (0.84      | ) |                                                                         | $ | (749.29 | ) |  |   |          |  
|                                                                                      |  |                             |            |   |                                                                         |   |         |   |  |   |          |  
|Weighted average number of common shares used in net loss per sharebasic and diluted |  |                             | 20,969,257 |   |                                                                         |   | 25,282  |   |  |   |          |  
|(1)    Amounts include stock-based compensation expense, as follows:                  |  |                             |            |   |                                                                         |   |         |   |  |   |          |  
|                                                                                      |  |                             |           
|Research and development                                                              |  | $                           | 257        |   |                                                                         | $ | 8       |   |  | $ | 2,149    |  
|General and administrative                                                            |  |                             | 215        |   |                                                                         |   | 11      |   |  |   | 2,001    |  

The accompanying notes are an integral part of these consolidated financial statements.



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##### Table of Contents

Targanta Therapeutics Corporation

(A development-stage company)

Condensed Consolidated Statements of Cash Flows

(in thousands)

(Unaudited)



|                                                                              |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|----------------------------------------------------------------------------- |  | ---------------------------- | ------- | - | ----------------------------------------------------------------------- | - | ------- | - |  | - | -------- | -
|                                                                              |  | Three Months Ended March 31, |         |   | For the Periodfrom May 20, 1997(date of inception)through March 31,2008 |  
|                                                                              |  | 2008                         |         |   | 2007                                                                    |   |        
|Cash flows from operating activities:                                         |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|Net loss                                                                      |  | $                            | (17,625 | ) |                                                                         | $ | (18,719 | ) |  | $ | (144,556 | )
|Adjustments to reconcile net loss to net cash used in operating activities:   |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|Depreciation and amortization                                                 |  |                              | 160     |   |                                                                         |   | 96      |   |  |   | 3,065    |  
|Stock-based compensation expense                                              |  |                              | 472     |   |                                                                         |   | 19      |   |  |   | 4,150    |  
|Gain on disposal of property and equipment                                    |  |                              |        |   |                                                                         |   |        |   |  |   | (47      | )
|Amortization of deferred financing costs                                      |  |                              | 8       |   |                                                                         |   | 338     |   |  |   | 687      |  
|Deferred rent                                                                 |  |                              | (4      | ) |                                                                         |   | 1       |   |  |   | 76       |  
|Acquired in-process research and development                                  |  |                              |        |   |                                                                         |   | 7,500   |   |  |   | 26,000   |  
|Non-cash interest expense                                                     |  |                              | 77      |   |                                                                         |   | 1,691   |   |  |   | 17,404   |  
|Unrealized foreign exchange loss                                              |  |                              | 17      |   |                                                                         |   | 263     |   |  |   | 1,675    |  
|Changes in operating assets and liabilities:                                  |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|Investment tax credits recoverable                                            |  |                              | 308     |   |                                                                         |   | (73     | ) |  |   | 153      |  
|Prepaid expenses and other current assets                                     |  |                              | (154    | ) |                                                                         |   | (1,061  | ) |  |   | (1,683   | )
|Deposits                                                                      |  |                              | (16     | ) |                                                                         |   |        |   |  |   | (63      | )
|Accounts payable                                                              |  |                              | 933     |   |                                                                         |   | (458    | ) |  |   | 1,927    |  
|Accrued expenses                                                              |  |                              | 2,555   |   |                                                                         |   | 319     |   |  |   | 5,883    |  
|Income tax payable                                                            |  |                              | (2,058  | ) |                                                                         |   | 2,336   |   |  |   | 279      |  
|Reimbursement from landlord                                                   |  |                              |        |   |                                                                         |   |        |   |  |   | 30       |  
|Deferred income tax                                                           |  |                              |        |   |                                                                         |   | (2,212  | ) |  |   | (222     | )
|                                                                              |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|Net cash used in operating activities                                         |  |                              | (15,327 | ) |                                                                         |   | (9,960  | ) |  |   | (85,242  | )
|                                                                              |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|                                                                              |  |                              |        
|Cash flows from investing activities:                                         |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|Purchases of property and equipment                                           |  |                              | (77     | ) |                                                                         |   | (110    | ) |  |   | (2,887   | )
|Proceeds from sale of property and equipment                                  |  |                              |        |   |                                                                         |   |        |   |  |   | 105      |  
|Increase in restricted cash                                                   |  |                              |        |   |                                                                         |   |        |   |  |   | (282     | )
|Proceeds from sales and maturities of short-term investments                  |  |                              | 24,909  |   |                                                                         |   |        |   |  |   | 44,198   |  
|Purchases of short-term investments                                           |  |                              | (7,208  | ) |                                                                         |   |        |   |  |   | (82,486  | )
|                                                                              |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|Net cash provided by (used in) investing activities                           |  |                              | 17,624  |   |                                                                         |   | (110    | ) |  |   | (41,352  | )
|                                                                              |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|                                                                              |  |                              |        
|Cash flows from financing activities:                                         |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|Proceeds from bank loan                                                       |  |                              |        |   |                                                                         |   |        |   |  |   | 327      |  
|Payments on bank loan                                                         |  |                              |        |   |                                                                         |   |        |   |  |   | (337     | )
|Proceeds from issuance of note payable                                        |  |                              |        |   |                                                                         |   |        |   |  |   | 6,470    |  
|Payments on note payable                                                      |  |                              |        |   |                                                                         |   |        |   |  |   | (10,044  | )
|Principal payments under capital leases                                       |  |                              |        |   |                                                                         |   |        |   |  |   | (1,273   | )
|Proceeds from issuance of convertible notes                                   |  |                              |        |   |                                                                         |   |        |   |  |   | 11,763   |  
|Payments on convertible notes                                                 |  |                              |        |   |                                                                         |   | (2,177  | ) |  |   | (2,177   | )
|Proceeds from issuance of convertible debentures                              |  |                              |        |   |                                                                         |   |        |   |  |   | 14,028   |  
|Proceeds from issuance of long-term debt                                      |  |                              |        |   |                                                                         |   |        |   |  |   | 20,000   |  
|Payments on long-term debt                                                    |  |                              | (1,111  | ) |                                                                         |   |        |   |  |   | (1,111   | )
|Proceeds from issuance of preferred stock and warrants, net of issuance costs |  |                              |        |   |                                                                         |   | 57,825  |   |  |   | 69,154   |  
|Proceeds from issuance of common stock, net of issuance costs                 |  |                              |        |   |                                                                         |   |        |   |  |   | 53,683   |  
|Deferred financing costs                                                      |  |                              |        |   |                                                                         |   | (83     | ) |  |   | (812     | )
|                                                                              |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|Net cash (used in) provided by financing activities                           |  |                              | (1,111  | ) |                                                                         |   | 55,565  |   |  |   | 159,671  |  
|                                                                              |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|Net increase in cash and cash equivalents                                     |  |                              | 1,186   |   |                                                                         |   | 45,495  |   |  |   | 33,077   |  
|Effect of foreign currency on cash and cash equivalents                       |  |                              |        |   |                                                                         |   |        |   |  |   | 1,064    |  
|                                                                              |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|Cash and cash equivalents, beginning of period                                |  |                              | 32,955  |   |                                                                         |   | 12,104  |   |  |   |         |  
|                                                                              |  |                              |         |   |                                                                         |   |         |   |  |   |          |  
|Cash and cash equivalents, end of period                                      |  | $                            | 34,141  |   |                                                                         | $ | 57,599  |   |  | $ | 34,141   |  
|                                                                              |  |                              |         |   |                                                                         |   |         |   |  |   |          |  



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##### Table of Contents

Targanta Therapeutics Corporation

(A development-stage company)

Condensed Consolidated Statements of Cash
Flows (continued)

(in thousands)

(Unaudited)



|                                                                                                   |  |                              |       |      |                                                                         |         |   |  |   |         |  
|-------------------------------------------------------------------------------------------------- |  | ---------------------------- | ----- | ---- | ----------------------------------------------------------------------- | ------- | - |  | - | ------- | -
|                                                                                                   |  | Three Months Ended March 31, |       |      | For the Periodfrom May 20, 1997(date of inception)through March 31,2008 |        
|                                                                                                   |  | 2008                         |       | 2007 |                                                                         |        
|Supplemental disclosure of cash flow information                                                   |  |                              |       |      |                                                                         |         |   |  |   |         |  
|Cash paid for interest                                                                             |  | $                            | 557   |      | $                                                                       | 180     |   |  | $ | 1,606   |  
|Cash paid for income taxes                                                                         |  |                              | 2,027 |      |                                                                         |        |   |  |   | 2,027   |  
|                                                                                                   |  |                              |      
|Supplemental disclosure of non-cash financing activities                                           |  |                              |       |      |                                                                         |         |   |  |   |         |  
|Discount to note payable for warrant valuation                                                     |  | $                            |      |      | $                                                                       |        |   |  | $ | 406     |  
|Issuance of InterMune convertible note                                                             |  | $                            |      |      | $                                                                       | 7,500   |   |  | $ | 24,000  |  
|Reduction of InterMune convertible note                                                            |  | $                            |      |      | $                                                                       | (3,000  | ) |  | $ | (3,000  | )
|Discount to convertible notes for warrant valuation and beneficial conversion features             |  | $                            |      |      | $                                                                       |        |   |  | $ | 11,715  |  
|Discount to convertible debentures for beneficial conversion features                              |  | $                            |      |      | $                                                                       |        |   |  | $ | 8,724   |  
|Conversion of convertible debt into preferred stock                                                |  | $                            |      |      | $                                                                       | (38,990 | ) |  | $ | (46,642 | )
|Reversal of beneficial conversion features in connection with conversion of convertible debentures |  | $                            |      |      | $                                                                       | (7,026  | ) |  | $ | (7,026  | )
|Discount to long-term debt for warrant valuation                                                   |  | $                            |      |      | $                                                                       |        |   |  | $ | 253     |  
|Accretion of redeemable convertible preferred stock to redemption value                            |  | $                            |      |      | $                                                                       | 225     |   |  | $ | 5,327   |  
|Conversion of preferred stock into common stock                                                    |  | $                            |      |      | $                                                                       |        |   |  | $ | 121,534 |  

The accompanying notes are an integral part of these consolidated financial statements.



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##### Table of Contents

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial Statements

(in thousands, except share and per share amounts)

(Unaudited)

1. Basis of Presentation

Targanta Therapeutics
Corporation (Parent), a Delaware corporation, was incorporated on December 6, 2005 to become the parent entity of Targanta Therapeutics Inc. (Targanta Québec) (previously PhageTech Inc.) and Targanta Therapeutics
(Ontario) Inc. (Targanta Ontario) as part of a reorganization that was effective December 23, 2005. Targanta Québec, a Canadian company, was incorporated on May 20, 1997 and Targanta Ontario, a Canadian company, was
incorporated on December 22, 2005. Targanta Therapeutics Corporation together with its subsidiaries (the Company) is a biopharmaceutical company focused on developing and commercializing antibacterial drugs to treat serious
infections in the hospital setting. The Companys pipeline includes an array of antibacterial agents in various stages of development. Oritavancin, the Companys lead product candidate, is a once-daily, semi-synthetic lipoglycopeptide
antibiotic with rapid bactericidal activity against all studied clinically relevant serious gram-positive pathogens, including multi-resistant strains. The Company has commenced its planned principal operations; however, the Company has not
generated any revenue from its operations. Accordingly, the Company is considered to be in the development stage as defined in Statement of Financial Accounting Standards (SFAS) No. 7, Accounting and Reporting by Development
Stage Enterprises. The Companys activities are carried out at its facilities in Cambridge, Massachusetts; Indianapolis, Indiana; and Montreal, Québec, Canada.

The accompanying consolidated financial statements have been prepared in accordance with accounting principles generally accepted in the United States
(GAAP) for interim financial reporting and as required by Regulation S-X, Rule 10-01. Accordingly, they do not include all of the information and footnotes required by GAAP for complete financial statements. In the opinion of management,
all adjustments (including those which are normal and recurring) considered necessary for a fair presentation of the interim financial information have been included. When preparing financial statements in conformity with GAAP, the Company must make
estimates and assumptions that affect the reported amounts of assets, liabilities, revenues, expenses and related disclosures at the date of the financial statements. Actual results could differ from those estimates. Additionally, operating results
for the three months ended March 31, 2008 are not necessarily indicative of the results that may be expected for any other interim period or for the year ending December 31, 2008.

The accompanying consolidated financial statements and notes thereto should be read in conjunction with the audited consolidated financial statements for
the year ended December 31, 2007 included in the Companys Annual Report on Form 10-K, which was filed with the Securities and Exchange Commission (SEC) on March 27, 2008.

2. Summary of Significant Accounting Policies

Principles of
Consolidation

The consolidated financial statements include the accounts of the Parent and its wholly-owned subsidiaries. All
significant intercompany accounts and transactions have been eliminated.

Cash and Cash Equivalents

The Company considers all short-term, highly liquid investments with original maturities of three months or less at acquisition date to be cash
equivalents. At March 31, 2008, the Company had invested its excess cash in money market accounts, overnight investment accounts, certificates of deposit, commercial paper, United States treasury bills and debt obligations of government
agencies. At December 31, 2007, the Company had invested its excess cash in money market accounts, overnight investment accounts, certificates of deposit and commercial paper. The Company did not hold any investments in mortgage-backed or
auction rate securities at March 31, 2008.



8



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##### Table of Contents

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial
Statements  (continued)

(in thousands, except share and per share amounts)

(Unaudited)



Short-term Investments

The Company accounts for its investments in accordance with SFAS No. 115, Accounting for Certain Investments in Debt and Equity Securities (SFAS No. 115). In accordance with SFAS
No. 115, the Company has classified all of its investments as available-for-sale at March 31, 2008 and December 31, 2007. The Companys investments are reported at fair value, with any unrealized gains or losses reported as a
separate component of stockholders equity as accumulated other comprehensive income.

Short-term investments included the following
at March 31, 2008 and December 31, 2007:



|                                        |  |               |        |                 |   |                  |  |   |            |   |  |   |       
|--------------------------------------- |  | ------------- | ------ | --------------- | - | ---------------- |  | - | ---------- | - |  | - | ------
|                                        |  | Amortizedcost |        | Unrealizedgains |   | Unrealizedlosses |  |   | Fair value
|March 31, 2008                         |  |               |        |                 |   |                  |  |   |            |   |  |   |       
|Commercial paper                        |  | $             | 18,852 |                 | $ | 96               |  | $ |           |   |  | $ | 18,948
|Corporate obligations                   |  |               | 2,851  |                 |   | 1                |  |   |           |   |  |   | 2,852 
|Asset backed securities                 |  |               | 15,269 |                 |   | 70               |  |   |           |   |  |   | 15,339
|Debt obligations of government agencies |  |               | 1,982  |                 |   |                 |  |   |           |   |  |   | 1,982 
|                                        |  |               |        |                 |   |                  |  |   |            |   |  |   |       
|                                        |  | $             | 38,954 |                 | $ | 167              |  | $ |           |   |  | $ | 39,121
|                                        |  |               |        |                 |   |                  |  |   |            |   |  |   |       
|December 31, 2007                      |  |               |        |                 |   |                  |  |   |            |   |  |   |       
|Commercial paper                        |  | $             | 34,080 |                 | $ | 121              |  | $ |           |   |  | $ | 34,201
|Corporate obligations                   |  |               | 4,861  |                 |   |                 |  |   | (6         | ) |  |   | 4,855 
|Asset backed securities                 |  |               | 17,725 |                 |   | 18               |  |   | (1         | ) |  |   | 17,742
|                                        |  |               |        |                 |   |                  |  |   |            |   |  |   |       
|                                        |  | $             | 56,666 |                 | $ | 139              |  | $ | (7         | ) |  | $ | 56,798
|                                        |  |               |        |                 |   |                  |  |   |            |   |  |   |       

All short-term investments have contractual maturities of less than one year.

The aggregate fair value of investments with unrealized losses was $0 and approximately $6,824 at March 31, 2008 and December 31, 2007,
respectively. At March 31, 2008, no investments were in an unrealized loss position. The Company reviews its investments for other-than-temporary impairment whenever the fair value of an investment is less than amortized cost and evidence
indicates that an investments carrying amount is not recoverable within a reasonable period of time. To determine whether an impairment is other-than-temporary, the Company considers whether it has the ability and intent to hold the investment
until a market price recovery and considers whether evidence indicating the cost of the investment is recoverable outweighs evidence to the contrary.

The cost of securities sold is determined based on the specific identification method for purposes of recording realized gains and losses. Gross realized gains and losses on the sales of investments have not been
material to the Companys consolidated results of operations.

Restricted Cash

The Company maintains restricted cash in the form of a guaranteed investment certificate of approximately $487 (CAN$500) collateralizing an available
credit facility of approximately $487 (CAN$500), comprised of a credit line of approximately $273 (CAN$280) and letters of guarantee maturing in March 2009 amounting to approximately $214 (CAN$220).

Concentration of Credit Risk

The Company maintains
its cash, cash equivalents, short-term investments and restricted cash with high quality financial institutions, and accordingly, is subject to minimal credit risk. The Company performs periodic evaluations of the relative credit quality of
investments and the Companys policy is designed to limit exposure to any one institution or type of investment. The primary objective of the Companys investment strategy is the preservation of the principal invested. Investment tax
credits recoverable were due from the Canadian federal and Québec provincial governments. The Company does not maintain foreign exchange contracts or other off-balance sheet financial instruments.



9



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##### Table of Contents

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial
Statements  (continued)

(in thousands, except share and per share amounts)

(Unaudited)



Fair Value of Financial Instruments

Cash, cash equivalents, short-term investments, restricted cash, investment tax credits recoverable, accounts payable, accrued expenses and the current
portion of long-term debt are carried at amounts that approximate fair value at March 31, 2008 and December 31, 2007 due to their short-term maturities.

Long-term debt approximates fair value at March 31, 2008, as it bears interest at a rate approximating a market interest rate.

On January 1, 2008, the Company adopted the provisions of SFAS No. 157, Fair Value Measurements (SFAS No. 157) for its financial assets and other items that are recognized or
disclosed at fair value on a recurring basis. This statement, among other things, defines fair value, establishes a framework for measuring fair value and expands disclosures about fair value measurements. In February 2008, the Financial Accounting
Standards Board (FASB) issued FASB Staff Position 157-2 (FSP 157-2), which delays the effective date of SFAS No. 157 for all nonfinancial assets and nonfinancial liabilities, except those that are recognized or disclosed
at fair value in the financial statements on a recurring basis, until fiscal years beginning after November 15, 2008 and interim periods within those years. The partial adoption of SFAS No. 157 for financial assets and liabilities
recognized at fair value on a recurring basis, in accordance with FSP 157-2, did not have a material effect on the Companys consolidated financial statements.

SFAS No. 157 clarifies that fair value is an exit price, representing the amount that would be received to sell an asset or paid to transfer a liability in an orderly transaction between market participants. As
such, fair value is a market-based measurement that should be determined based on assumptions that market participants would use in pricing an asset or liability. As a basis for considering such assumption, SFAS No. 157 established a three-tier
fair value hierarchy, which prioritizes the inputs used in measuring fair value as follows:



| |  |  | Level 1  Observable inputs such as quoted prices in active markets;
| | - |  | --------------------------------------------------------------------



| |  |  | Level 2  Inputs, other than the quoted prices in active markets, that are observable either directly or indirectly; and
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | Level 3  Unobservable inputs in which there is little or no market data, which require the reporting entity to develop its own assumptions.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------

The Companys investment portfolio includes many fixed income securities that do not always trade on a daily basis.
As a result, the pricing services used by the Company applied other available information as applicable through processes such as benchmark yields, benchmarking of like securities, sector groupings and matrix pricing to prepare evaluations. In
addition, model processes were used to assess interest rate impact and develop prepayment scenarios. These models take into consideration relevant credit information, perceived market movements, sector news and economic events. The inputs into these
models may include benchmark yields, reported trades, broker-dealer quotes, issuer spreads and other relevant data.

In accordance with the
disclosure provisions of SFAS No. 157, the Company has classified assets measured at fair value on a recurring basis as follows:



|                              |  |               |                                                             |                                                 |                                            |       |                                        |   |        |  |   |  
|----------------------------- |  | ------------- | ----------------------------------------------------------- | ----------------------------------------------- | ------------------------------------------ | ----- | -------------------------------------- | - | ------ |  | - | -
|                              |  | March 31,2008 |                                                             | Fair Value Measurements at Reporting Date Using
|Description                   |  |               | Quoted Prices inActive Markets forIdentical Assets(Level 1) |                                                 | Significant OtherObservableInputs(Level
2) |       | SignificantUnobservableInputs(Level
3)
|Available-for-sale securities |  | $             | 39,121                                                      |                                                 | $                                          | 1,982 |                                        | $ | 37,139 |  | $ | 



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##### Table of Contents

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial
Statements  (continued)

(in thousands, except share and per share amounts)

(Unaudited)



Research and Development Costs

The Company charges research and development costs to operations as incurred in accordance with SFAS No. 2, Accounting for Research and Development Costs and EITF Issue No. 07-3, Accounting for
Nonrefundable Advance Payments for Goods or Services to Be Used in Future Research and Development Activities. Research and development costs are comprised of costs incurred in performing research and development activities, including salaries,
benefits, facilities, research-related overhead, contracted services, license fees, and other external costs. Acquired in-process research and development having no alternative future use is written off at the time of acquisition. In addition, as
pre-established research and development milestones under the Companys various agreements are achieved, they are charged to acquired in-process research and development expense. Acquired in-process research and development expense for the
three months ended March 31, 2007 includes a $2,000 cash payment and the fair value of the securities issued to InterMune, Inc. (InterMune) in connection with the Companys achievement of certain milestones.

Net Loss per Share

The Company calculates net loss
per share in accordance with SFAS No. 128, Earnings Per Share. Basic and diluted net loss per common share was determined by dividing net loss by the weighted average number of shares of common stock outstanding during the period. The
Companys potentially dilutive shares, which include convertible preferred stock, outstanding stock options exercisable for shares of common stock and warrants exercisable for common and preferred stock, have not been included in the
computation of diluted net loss per share for all periods as the result would be anti-dilutive.



|                                                                                                 |  |                              |            |   |      |   |         |  
|------------------------------------------------------------------------------------------------ |  | ---------------------------- | ---------- | - | ---- | - | ------- | -
|                                                                                                 |  | Three Months Ended March 31, |           
|                                                                                                 |  | 2008                         |            |   | 2007 |  
|As reported:                                                                                     |  |                              |            |   |      |   |         |  
|Net loss                                                                                         |  | $                            | (17,625    | ) |      | $ | (18,719 | )
|Accretion of Series B Redeemable Convertible Preferred Stock dividends                           |  |                              |           |   |      |   | (225    | )
|                                                                                                 |  |                              |            |   |      |   |         |  
|Net loss applicable to common stockholders                                                       |  |                              | (17,625    | ) |      |   | (18,944 | )
|                                                                                                 |  |                              |            |   |      |   |         |  
|Weighted-average number of shares of common stock used in net loss per share  basic and diluted |  |                              | 20,969,257 |   |      |   | 25,282  |  
|                                                                                                 |  |                              |            |   |      |   |         |  
|Net loss per share applicable to common stockholders  basic and diluted                         |  | $                            | (0.84      | ) |      | $ | (749.29 | )
|                                                                                                 |  |                              |            |   |      |   |         |  

The following potentially dilutive securities have been excluded from the computation of diluted
weighted average shares outstanding during the three months ended March 31, 2008 and 2007.



|                            |  |                              |  |          
|--------------------------- |  | ---------------------------- |  | ---------
|                            |  | Three Months Ended March 31,
|                            |  | 2008                         |  | 2007     
|Convertible preferred stock |  |                             |  | 9,935,665
|Warrants outstanding        |  | 850,287                      |  | 529,867  
|Options outstanding         |  | 3,531,082                    |  | 57,500   



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##### Table of Contents

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial
Statements  (continued)

(in thousands, except share and per share amounts)

(Unaudited)



Comprehensive Income (Loss)

The Company has applied the provisions of SFAS No. 130, Reporting Comprehensive Income, which requires that all components of comprehensive income (loss) be reported in the period in which they are
recognized. Comprehensive income (loss) is defined as the change in equity of a business enterprise during a period from transactions and other events and circumstances from non-owner sources. Other than the Companys net loss, the other
element of comprehensive income (loss) impacting the Company is unrealized gains on marketable securities.



|                                           |  |                             |         |   |      |   |         |  
|------------------------------------------ |  | --------------------------- | ------- | - | ---- | - | ------- | -
|                                           |  | Three Months EndedMarch 31, |        
|                                           |  | 2008                        |         |   | 2007 |  
|As reported:                               |  |                             |         |   |      |   |         |  
|Net loss applicable to common stockholders |  | $                           | (17,625 | ) |      | $ | (18,944 | )
|Other comprehensive income (loss):         |  |                             |         |   |      |   |         |  
|Unrealized gain on marketable securities   |  |                             | 23      |   |      |   |        |  
|                                           |  |                             |         |   |      |   |         |  
|Comprehensive loss                         |  | $                           | (17,602 | ) |      | $ | (18,944 | )
|                                           |  |                             |         |   |      |   |         |  

Canadian Part VI.I Tax

The Company has accrued the potential Canadian Part VI.I tax related to the cumulative dividend on its Series B Redeemable Convertible Preferred Stock. The Company applied the provisions of EITF Issue No. 95-9,
Accounting for Tax Effects of Dividends in France in Accordance with FASB Statement No. 109, in accounting for the Canadian Part VI.I tax, which states that unless specific criteria are met, taxes on distributions should be treated as an
income tax expense. The Part VI.I tax liability of approximately $2,731 was presented as a current tax liability in the December 31, 2007 consolidated balance sheet. In February 2008, the Company paid approximately $2,026 of the Part VI.I tax
liability to the Canadian tax authority. The Canadian government voted to approve, but has not given final approval to, a reduction in the Part VI.I tax rate. The February 2008 payment was made at the reduced tax rate. The remaining Part VI.I tax
liability of approximately $656 is presented as a current tax liability in the March 31, 2008 consolidated balance sheet and will be reversed if and when the Canadian government finally approves the Part VI.I tax rate reduction.

Investment Tax Credits

Canadian federal and
Québec and Ontario provincial investment tax credits are accounted for as a reduction of the income tax expense in the period in which the credits are earned and when there is reasonable assurance of their recovery.

Segment and Geographic Information

SFAS
No. 131, Disclosures about Segments of an Enterprise and Related Information (SFAS No. 131), established standards for reporting information about operating segments in annual financial statements and requires selected
information about operating segments to be presented in interim financial reports issued to stockholders. SFAS No. 131 also established standards for disclosures about products and services and geographic areas. Operating segments are defined
as components of an enterprise about which separate discrete financial information is available for evaluation by the chief operating decision maker, or decision-making group, in deciding how to allocate resources and in assessing performance. The
Company views its operations and manages its business in one operating segment and the Company operates in only two geographic segments, the United States and Canada.



12



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##### Table of Contents

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial
Statements  (continued)

(in thousands, except share and per share amounts)

(Unaudited)



The Companys long-lived assets included the following:



|         |  |               |       |                  |   |      
|-------- |  | ------------- | ----- | ---------------- | - | -----
|         |  | March 31,2008 |       | December 31,2007
|Domestic |  | $             | 775   |                  | $ | 850  
|Canada   |  |               | 492   |                  |   | 500  
|         |  |               |       |                  |   |      
|         |  | $             | 1,267 |                  | $ | 1,350
|         |  |               |       |                  |   |      

Recent Accounting Pronouncements

In December, 2007, EITF 07-01, Accounting for Collaborative Arrangements Related to the Development and Commercialization of Intellectual Property
(EITF 07-01), was issued. EITF 07-01 prescribes the accounting for collaborations, requiring that, when certain characteristics exist in collaboration relationships, certain transactions between collaborators be recorded within expenses
in the statement of operations on either a gross or net basis. The Company currently has no collaborations that are impacted by EITF 07-01. The Company will evaluate any future collaborations under this guidance, as appropriate.

Reclassifications

Certain reclassifications were
made to prior year balances to conform to the current presentation.

3. Accrued Expenses

Accrued expenses consist of the following:



|                                               |  |               |       |                  |   |      
|---------------------------------------------- |  | ------------- | ----- | ---------------- | - | -----
|                                               |  | March 31,2008 |       | December 31,2007
|Payroll and benefits                           |  | $             | 1,156 |                  | $ | 1,382
|Professional fees                              |  |               | 469   |                  |   | 545  
|Clinical expenses                              |  |               | 3,962 |                  |   | 3,202
|Manufacturing and process development expenses |  |               | 2,062 |                  |   | 301  
|Other                                          |  |               | 770   |                  |   | 443  
|                                               |  |               |       |                  |   |      
|                                               |  | $             | 8,419 |                  | $ | 5,873
|                                               |  |               |       |                  |   |      

4. Commitments

The Company leases its laboratory and office space under operating lease agreements with various terms and renewal options with lease expirations ranging from 2009 through 2012. In addition to minimum lease
commitments, these lease agreements require the Company to pay its pro rata share of property taxes and building operating expenses.

In
March 2008, the Company amended its lease for one of its Montreal, Québec locations to extend the term through March 2009. Also in March 2008, the Company executed a second amendment to its Cambridge, Massachusetts lease, effective no earlier
than May 1, 2008, which amendment provides for an expansion of the rentable space by an additional one-thousand seven-hundred thirty-nine square feet. The amended Cambridge lease has escalating rent payments over the lease term and expires in
October 2009.



13



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##### Table of Contents

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial
Statements  (continued)

(in thousands, except share and per share amounts)

(Unaudited)



5. Stock-Based Compensation

Stock Option Plans

At March 31, 2008, the Companys 2005 Stock Option Plan (2005
Plan) provided for the grant of options for the purchase of 2,360,318 shares of common stock plus any shares of common stock covered by outstanding options under the Re-Amended and Restated Stock Option Plan of Targanta Québec
(Targanta Québec Plan) that are forfeited and returned for reissuance under the Targanta Québec Plan, such number not to exceed 3,597 shares of common stock. As a result, at March 31, 2008, the maximum aggregate number
of shares of common stock available for issuance under the 2005 Plan was 2,363,915. The Company is no longer permitted to make grants under the 2005 Plan or the Targanta Québec Plan. At March 31, 2008, there were 433 shares of common
stock remaining under the 2005 Plan, none of which were available for future grant.

At March 31, 2008, the Companys 2007 Stock
Option and Incentive Plan (2007 Plan) provided for the grant of options for the purchase of 2,006,084 shares of common stock. The 2007 Plan permits the Company to make grants of incentive stock options, non-qualified stock options, stock
appreciation rights, deferred stock awards, restricted stock awards, unrestricted stock awards and cash-based awards. The number of shares available for future grant under the 2007 Plan will automatically increase each year by an amount equal to
3.5% of all shares of the Companys capital stock outstanding on December 31st of each preceding year unless the Companys board of directors takes action in any given year to set this increase at a lesser amount. Accordingly, on
February 6, 2008, the Companys board of directors increased the aggregate number of shares available for grant under the 2007 Plan by 733,921. Generally, shares that are forfeited or canceled from awards under the 2007 Plan also will be
available for future awards. In addition, awards that are returned to the Companys 2005 Plan as a result of their expiration, cancellation, termination or repurchase are automatically made available for issuance under the 2007 Plan.

The Company adopted SFAS No. 123 (revised 2004), Share Based Payment (SFAS No. 123(R)), effective January 1, 2006.
In connection with the adoption of SFAS No. 123(R), the Company reassessed the valuation methodology for stock options and the related input assumptions. The assessment of the valuation methodology resulted in the continued use of the
Black-Scholes model. Prior to October 9, 2007, the date the Companys Registration Statement on Form S-1, as amended, was declared effective, the Company was a private company and did not have relevant historical data to support its
expected term and volatility. As such, the Company analyzed the expected term and volatility of several peer companies to support the assumptions used in its fair value calculations. The Company averaged the volatilities and expected terms of the
peer companies with sufficient trading history, similar vesting terms and similar in-the-money option status to generate the assumptions detailed below.

The following table summarizes the weighted-average assumptions the Company used in its grant date fair value calculations under SFAS No. 123(R):



|                        |  |                              |   |  |           |  
|----------------------- |  | ---------------------------- | - |  | --------- | -
|                        |  | Three Months Ended March 31, |  
|                        |  | 2008                         |   |  | 2007      |  
|Risk-free interest rate |  | 2.90                         | % |  | 4.57      | %
|Expected dividend yield |  | None                         |   |  | None      |  
|Expected option term    |  | 4.98 years                   |   |  | 5.4 years |  
|Volatility              |  | 51.4                         | % |  | 64.1      | %

SFAS No. 123(R) requires the application of an estimated forfeiture rate to current period
expense to recognize compensation expense only for those awards expected to vest. The Company estimates forfeitures based upon comparable companies data and adjusts its estimate of forfeitures if actual forfeitures differ, or are expected to
differ from the Companys estimates. Subsequent changes in estimated forfeitures will be recognized through a cumulative catch-up adjustment in the period of change and will also impact the amount of stock-based compensation expense in future
periods.

The weighted average grant date fair value of options granted during the three months ended March 31, 2008 was $4.01 based
on the assumptions in the Black-Scholes valuation model discussed above. There were no option grants in the three months ended March 31, 2007.



14



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##### Table of Contents

Targanta Therapeutics Corporation

(A development-stage company)

Notes to Condensed Consolidated Financial
Statements  (continued)

(in thousands, except share and per share amounts)

(Unaudited)



As of March 31, 2008, there was $7,332 of unrecognized stock-based compensation expense. These
costs are expected to be recognized over a weighted average period of 3.11 years.

For the three months ended March 31, 2008 and 2007
and the period from May 20, 1997 (date of inception) to March 31, 2008, the total stock-based compensation expense in connection with stock options issued and outstanding amounted to:



|                         |  |                              |     |                                                                          |   |    |  |   |      
|------------------------ |  | ---------------------------- | --- | ------------------------------------------------------------------------ | - | -- |  | - | -----
|                         |  | Three Months Ended March 31, |     | For the Periodfrom May 20, 1997(date of
inception)through March 31, 2008
|                         |  | 2008                         |     | 2007                                                                     |  
|Stock-based compensation |  | $                            | 472 |                                                                          | $ | 19 |  | $ | 4,150

A summary of the status of the Companys stock option plans at March 31, 2008 and
changes during the three months then ended is presented in the table below:



|                                             |  |                                             |   |  |                                        |      |                                                   |      |                         |   |      
|-------------------------------------------- |  | ------------------------------------------- | - |  | -------------------------------------- | ---- | ------------------------------------------------- | ---- | ----------------------- | - | -----
|                                             |  | Shares ofCommon StockAttributable toOptions |   |  | WeightedAverageExercisePrice ofOptions |      | WeightedAverageRemainingContractualTerm(in
years) |      | AggregateIntrinsicValue
|Outstanding at December 31, 2007             |  | 2,538,155                                   |   |  |                                        | 4.44 |                                                   |      |                         |   |      
|Granted                                      |  | 1,026,550                                   |   |  |                                        | 8.45 |                                                   |      |                         |   |      
|Exercised                                    |  |                                            |   |  |                                        |     |                                                   |      |                         |   |      
|Cancelled                                    |  | (33,623                                     | ) |  |                                        | 7.53 |                                                   |      |                         |   |      
|                                             |  |                                             |   |  |                                        |      |                                                   |      |                         |   |      
|Outstanding at March 31, 2008                |  | 3,531,082                                   |   |  | $                                      | 5.57 |                                                   | 9.33 |                         | $ | 8,795
|                                             |  |                                             |   |  |                                        |      |                                                   |      |                         |   |      
|Vested or expected to vest at March 31, 2008 |  | 3,403,005                                   |   |  | $                                      | 5.56 |                                                   | 9.33 |                         | $ | 8,530
|                                             |  |                                             |   |  |                                        |      |                                                   |      |                         |   |      
|Exercisable at March 31, 2008                |  | 969,539                                     |   |  | $                                      | 4.31 |                                                   | 9.05 |                         | $ | 3,505
|                                             |  |                                             |   |  |                                        |      |                                                   |      |                         |   |      



15



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##### Table of Contents

|Item 2. | Managements Discussion and Analysis of Financial Condition and Results of Operations
|------- | -------------------------------------------------------------------------------------

The following discussion contains forward-looking statements, which involve risks and uncertainties. Our actual results could differ materially from
those anticipated in these forward-looking statements as a result of various factors, including those set forth below under Part II, Item 1A, Risk Factors. The interim financial statements and this Managements Discussion and
Analysis of Financial Condition and Results of Operations should be read in conjunction with the financial statements and notes thereto for the year ended December 31, 2007 and the related Managements Discussion and Analysis of Financial
Condition and Results of Operations, both of which are contained in our Annual Report on Form 10-K filed with Securities and Exchange Commission on March 27, 2008. Except as required by law, we assume no obligation to update these
forward-looking statements, whether as a result of new information, future events or otherwise.

Overview

We are a biopharmaceutical company focused on the development and commercialization of innovative antibiotics for serious infections treated or acquired
in hospitals and other institutional settings. Our lead product candidate is oritavancin, a novel intravenous antibiotic, for the treatment of serious gram-positive bacterial infections including complicated skin and skin structure infections
(cSSSI) and bacteremia. In February 2008, we submitted a New Drug Application (NDA) to the U.S. Food and Drug Administration (FDA) seeking to commercialize oritavancin for the treatment of cSSSI, including
infections caused by methicillin-resistant Staphylococcus aureus (MRSA). We are hopeful oritavancin will receive U.S. regulatory approval by the end of 2008. We also expect to file for European approval of oritavancin for the
treatment of complicated skin and soft tissue infections (cSSTI) prior to the middle of July 2008. We plan on commercializing oritavancin through our own direct sales force in the U.S. and in select other countries, and to out-license
oritavancin to third parties in other countries as we deem appropriate. In addition, we have discovered another antibiotic that is currently in pre-clinical development for osteomyelitis, and we continually evaluate opportunities for potential
in-licensing of other antibiotics for the treatment of hospital-based infections.

We acquired worldwide rights to oritavancin from
InterMune, Inc. (InterMune) in December 2005, and believe that since then we have greatly improved the commercial and economic prospects for the drug by resolving several important issues with the FDA and by substantially lowering the
royalty rate that may be payable to Eli Lilly and Company (Lilly), the original discoverer of oritavancin. Our strategy is to capitalize on the unique attributes of oritavancin to develop it into a leading therapy worldwide for the
treatment of serious gram-positive infections, initially for cSSSI and subsequently for other indications.

We were incorporated as a
Delaware corporation on December 6, 2005 and initiated operations through our Québec subsidiary in May 1997 in Montreal, Québec. To date, we have dedicated substantially all of our activities to the research and development of our
drug candidates. Accordingly, we are considered to be in the development stage at March 31, 2008, as defined in SFAS No. 7, Accounting and Reporting by Development Stage Enterprises. Our fiscal year ends on December 31 and we
operate as one reportable segment. Prior to our acquisition of oritavancin in December 2005, we were focused on early-stage research in the area of antibiotics and the application of our proprietary phage technology.

On October 9, 2007, the Securities and Exchange Commission (SEC) declared our Registration Statement on Form S-1, as amended, for our
initial public offering of 5.75 million shares of our common stock (Registration No. 333-142842) effective. We sold the shares of common stock in this initial public offering at a price of $10.00 per share. We received net proceeds of
approximately $51.1 million after deducting underwriting discounts and commissions and offering expenses of approximately $2.3 million.

We
have not generated any revenue to date from product sales and have incurred significant operating losses since our inception in 1997. We incurred net losses of $63.3 million for the year ended December 31, 2007 and $17.6 million for the three
months ended March 31, 2008. As of March 31, 2008, we had a deficit accumulated during the development stage of $144.6 million and we expect to incur losses for the foreseeable future.

We expect to incur substantial expenditures in the foreseeable future for the continued development of our product candidates and, if we obtain
regulatory approval, for the commercialization of those products. We expect to continue to incur operating losses for at least the next several years and we will need additional financing to support our activities. We will seek to fund our
operations through public or private equity or debt financings or other sources, such as collaborations and revenue from the sale of oritavancin, if approved by the FDA. Adequate additional funding may not be available to us on acceptable terms, or
at all. Our failure to raise capital as and when needed could have a negative impact on our financial condition and our ability to pursue our business strategies. If adequate funds are not available to us, we may be required to delay, reduce or
eliminate research and development programs, reduce or eliminate commercialization efforts, obtain funds through arrangements with collaborators or others on terms unfavorable to us or pursue merger or acquisition strategies.



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Critical Accounting Policies

We believe that several accounting policies are important to understanding our historical and future performance. We refer to these policies as critical because these specific areas generally require us to
make judgments and estimates about matters that are uncertain at the time we make the estimate, and different estimates  which also would have been reasonable  could have been used, which would have resulted in different financial
results. It is important that the discussion of our operating results that follows be read in conjunction with the critical accounting policies disclosed in our Annual Report on Form 10-K filed with the SEC on March 27, 2008. There have been no
changes to these critical accounting policies in the three months ended March 31, 2008.

Results of Operations

Three months ended March 31, 2008 compared to three months ended March 31, 2007

Revenue. We recorded no revenue during the three months ended March 31, 2008 or 2007.

Operating
Expenses

The following table summarizes our operating expenses for the three months ended March 31, 2008 and 2007:



|                                                                     |  |                             |        |                              |   |       |  |      |   
|-------------------------------------------------------------------- |  | --------------------------- | ------ | ---------------------------- | - | ----- |  | ---- | --
|                                                                     |  | Three Months EndedMarch 31, |        | PercentageIncrease(Decrease) |  
|                                                                     |  | 2008                        |        | 2007                         |  
|                                                                     |  | (in thousands)              |        |                              |  
|Operating Expenses                                                   |  |                             |        |                              |   |       |  |      |   
|Research and development (1)                                         |  | $                           | 14,279 |                              | $ | 5,439 |  | 163  | % 
|Acquired in-process research and development                         |  | $                           |       |                              | $ | 9,500 |  | (100 | )%
|General and administrative (1)                                       |  | $                           | 3,618  |                              | $ | 1,935 |  | 87   | % 
|(1)    Amounts include stock-based compensation expense, as follows: |  |                             |        |                              |   |       |  |      |   
|Research and development                                             |  | $                           | 257    |                              | $ | 8     | 
|General and administrative                                           |  | $                           | 215    |                              | $ | 11    | 

Research and development expense

Research and development expense for the three months ended March 31, 2008 was $14.3 million, compared to $5.4 million for the three months ended
March 31, 2007. The $8.8 million increase during the three months ended March 31, 2008 was primarily the result of a $5.5 million increase in contract research expense, which included an increase of $3.7 million in clinical trials expense
resulting from clinical trials conducted and in-vitro clinical database work performed for the oritavancin program, as well as an increase of $1.8 million in third-party product manufacturing, validation and process development expense incurred in
preparation for the commercial launch of oritavancin. Additional factors that contributed to the increase in research and development expense were a $1.2 million increase in regulatory filing fees, due to filing of our NDA with the FDA and a $1.0
million increase in salaries and benefits expenses, mainly due an increased number of employees working on the oritavancin program. Our research and development expense also increased as a result of a $0.2 million increase in stock-based
compensation expense and a $0.6 million increase in professional services, primarily due to increased consulting and recruiting fees.



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Acquired in-process research and development expense

We did not record any acquired in-process research and development expense for the three months ended March 31, 2008, compared to $9.5 million for
the three months ended March 31, 2007. The $9.5 million acquired in-process research and development expense we incurred during the three months ended March 31, 2007 was due to a $2.0 million cash milestone payment to InterMune and a total
of $7.5 million of expense related to our achievement of the first milestone under the convertible note we had initially issued to InterMune in December 2005 in connection with our acquisition of oritavancin. This $7.5 million expense reflects the
fair value of the shares of our preferred stock and warrants to purchase shares of our preferred stock that we issued to InterMune upon our achievement of this milestone.

General and administrative expense

General and administrative expense for the three months
ended March 31, 2008 was $3.6 million, compared to $1.9 million for the three months ended March 31, 2007. The $1.7 million increase during the three months ended March 31, 2008 was primarily the result of a $0.5 million increase in
salaries and benefits expenses resulting from the hiring of additional administrative staff; and a $0.7 million increase in professional and consulting fees, comprised of a $0.3 million increase in consulting fees primarily related to oritavancin
pre-launch expenses, investor relations/public relations and administrative support expenses and a $0.4 million increase in insurance, legal fees and patent expenses. An additional factor contributing to the increase in general and administrative
expense during the three months ended March 31, 2008 was a $0.2 million increase in stock-based compensation expense.

Interest income

Interest income for the three months ended March 31, 2008 was $0.9 million, compared to $0.5 million for the three months ended
March 31, 2007. This $0.4 million, or 80%, increase for the three months ended March 31, 2008 was due to higher average cash, cash equivalents and short-term investments balances due to the receipt of approximately $57.8 million of net
proceeds from the January and February 2007 closings of our Series C financing transaction, the $20.0 million proceeds we received upon our issuance of the term notes to Merrill Lynch Capital and the two other lenders in late September 2007 (the
MLC Term Note) and $51.1 million of net proceeds from our October 2007 initial public offering.

Interest expense

Interest expense for the three months ended March 31, 2008 was $0.6 million, compared to $2.2 million for the period ended March 31, 2007. The
decrease of $1.6 million, or 73%, for the three months ended March 31, 2008 was primarily due to a $1.9 million decrease in interest expense and $0.3 million decrease in amortization of deferred financing costs resulting from the January 2007
conversion of the outstanding convertible notes and convertible debentures into shares of our preferred stock and the repayment of the loan to our former lender Investissement Québec by our Québec subsidiary; partially offset by a $0.6
million increase in interest expense related to the MLC Term Note.

Foreign Exchange loss

Foreign exchange loss for the three months ended March 31, 2008 was $19,000, compared to $64,000 in the three months ended March 31, 2007. This
decrease of $45,000, or 70%, resulted from the strengthening of the Canadian dollar as the foreign exchange loss is primarily a result of the translation adjustments resulting from the financial statements of our Canadian subsidiaries.

Income tax benefit (expense)

Income tax
benefit for the three months ended March 31, 2008 was $66,000, compared to an income tax expense of $29,000 for the three months ended March 31, 2007. The $95,000, or 328%, increase in income tax benefit for the three months ended
March 31, 2008 primarily resulted from no longer recording any Canadian Part VI.I income tax expense on the accumulated dividends related to our Series B Redeemable Convertible Preferred Stock as a result of the January 2007 payment of the
accrued dividend (and the associated termination of the cumulative dividend) on those shares.



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Liquidity and Capital Resources

On October 9, 2007, our Registration Statement on Form S-1, as amended, for our initial public offering of 5.75 million shares of our common stock was declared effective by the SEC. On October 15, 2007,
we sold these 5.75 million registered shares at a price of $10.00 per share. We received net proceeds of approximately $51.1 million from the offering after deducting underwriting discounts and commissions and offering expenses of approximately
$2.3 million.

Prior to our October 9, 2007 initial public offering, we financed our operations primarily through the sale of
preferred stock and common stock, debt financings, interest earned on investments and investment tax credits. Prior to our initial public offering, we had received aggregate gross proceeds of $125.8 million from financings, of which $70.4 million
was from the issuance of preferred stock, $2.7 million was from the issuance of common stock and $52.7 million was from debt financings. Our cash, cash equivalents, short-term investments and restricted cash include amounts held in money market
accounts, overnight investment accounts, guaranteed investment certificates, certificates of deposit, commercial paper, asset backed securities, United States treasury bills, debt obligations of government agencies and corporate obligations, stated
at cost plus accrued interest, which approximates fair market value. We invest cash in excess of immediate requirements in accordance with our investment policy, primarily to achieve liquidity and capital preservation. At March 31, 2008, we did
not own any mortgage backed securities or auction rate securities.

As of March 31, 2008, we had cash, cash equivalents and short-term
investments of approximately $73.3 million. We intend to use our cash to fund internal and external costs related to regulatory filings in Europe; to fund clinical trials for oritavancin in cSSSI using a single administration, including our ongoing
Phase 2 clinical trial entitled Single or Infrequent Doses for the Treatment of Complicated Skin and Skin Structure Infections or SIMPLIFI; and to continue the clinical development of oritavancin for other indications such as bacteremia;
in anticipation of regulatory approval, to fund commercial launch related expenses for oritavancin including manufacturing, marketing, and sales; to make regularly scheduled payments on our existing debt facilities, namely the MLC Term Note; and to
apply the remaining funds for general corporate purposes and the potential acquisition of, or investment in, technologies, products, or companies that complement our business.

The amounts and timing of our actual expenditures will depend upon numerous factors, including whether we obtain FDA approval for oritavancin and, if so,
the timing of such approval; the success of the commercial launch of oritavancin if approved by the FDA; our cash flows from operations; any potential acquisitions of or investments in technologies, products or companies; and the anticipated growth
of our business.

We expect our existing resources to be sufficient to fund our planned operations into the third quarter of 2009.

Cash Flows

The following table
summarizes our net increase in cash and cash equivalents for the three months ended March 31, 2008 and 2007:



|                                          |  |                             |         |   |      |   |        |  
|----------------------------------------- |  | --------------------------- | ------- | - | ---- | - | ------ | -
|                                          |  | Three Months EndedMarch 31, |        
|                                          |  | 2008                        |         |   | 2007 |  
|                                          |  | (in thousands)              |        
|Net cash provided by (used in):           |  |                             |         |   |      |   |        |  
|Operating activities                      |  | $                           | (15,327 | ) |      | $ | (9,960 | )
|Investing activities                      |  |                             | 17,624  |   |      |   | (110   | )
|Financing activities                      |  |                             | (1,111  | ) |      |   | 55,565 |  
|                                          |  |                             |         |   |      |   |        |  
|Net increase in cash and cash equivalents |  | $                           | 1,186   |   |      | $ | 45,495 |  
|                                          |  |                             |         |   |      |   |        |  

Net cash used in operating activities. Net cash used in operating activities was $15.3
million and $10.0 million for the three months ended March 31, 2008 and 2007, respectively, and primarily reflects our net loss for those periods. The increase in net cash used in the three months ended March 31, 2008 compared to the three
months ended March 31, 2007 was due primarily to a $7.5 million decrease in non-cash acquired in-process research and development expense; a $1.6 million decrease in non-cash interest expense; a $0.3 million decrease in amortization of deferred
financing costs expense; a $0.2 million decrease in unrealized foreign exchange loss; partially offset by a $1.1 million decrease in net loss, which was a result of higher interest income and lower interest expense as described above; a $2.7 million
increase in net changes in working capital items relating to operations; and an increase in non-cash stock-based compensation expense of $0.4 million.



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Net cash provided by (used in) investing activities. Net cash provided by investing activities was
$17.6 million for the three months ended March 31, 2008 and net cash used in investing activities was $0.1 million in the three months ended March 31, 2007. Investing activities consist primarily of purchases and sales of short-term
securities and capital purchases. The increase in cash provided by investing activities in the three months ended March 31, 2008 compared to the three months ended March 31, 2007 was primarily due to a $24.9 million increase in the
proceeds from the sales and maturities of short-term investments; partially offset by an increase of $7.2 million of cash used to purchase short-term investments.

Net cash (used in) provided by financing activities. Net cash used in financing activities was $1.1 million for the three months ended March 31, 2008 and net cash provided by financing activities was $55.6
million for the three months ended March 31, 2007. The increase in net cash used in the three months ended March 31, 2008 compared to the three months ended March 31, 2007 was primarily due to a decrease in proceeds from the issuance
of preferred stock and warrants of $57.8 million; an increase of payments on long-term debt of $1.1 million; partially offset by decrease in payments on convertible notes of $2.2 million.

Contractual obligations

In March 2008, the Company
amended its lease for one of its Montreal, Québec locations to extend the term through March 2009. Also in March 2008, the Company executed a second amendment to its Cambridge, Massachusetts lease, effective no earlier than May 1, 2008,
which amendment provides for an expansion of the rentable space by an additional one-thousand seven-hundred thirty-nine square feet. The amended Cambridge lease has escalating rent payments over the lease term and expires in October 2009.

During the fiscal quarter ended March 31, 2008, we did not incur any additional obligations that materially change the disclosure of our
contractual obligations in our Annual Report on Form 10-K filed with the SEC on March 27, 2008.

Off-balance sheet arrangements

We do not have any relationships with unconsolidated entities or financial partnerships, such as entities often referred to as structured finance or
special purpose entities, that would have been established for the purpose of facilitating off-balance sheet arrangements (as that term is defined in Item 303(a)(4)(ii) of Regulation S-K) or other contractually narrow or limited purposes.
As such, we are not exposed to any financing, liquidity, market or credit risk that could arise if we had engaged in those types of relationships.

Recently issued accounting pronouncements

In December, 2007, EITF 07-01,Accounting for Collaborative Arrangements
Related to the Development and Commercialization of Intellectual Property (EITF 07-01), was issued. EITF 07-01 prescribes the accounting for collaborations, requiring that, when certain characteristics exist in collaboration
relationships, certain transactions between collaborators be recorded within expenses in the income statement on either a gross or net basis. EITF 07-01 is effective for all of our collaborations existing after January 1, 2009. We currently
have no collaborations that are impacted by EITF 07-01. We will evaluate any future collaborations under this guidance, as appropriate.



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|Item 3. | Quantitative and Qualitative Disclosures about Market Risk
|------- | ----------------------------------------------------------

Interest Rate Risk

We are exposed to market risk related to changes in interest rates. As of March 31, 2008, we had
cash, cash equivalents and short-term investments of approximately $73.3 million. In accordance with our investment policy, this amount is invested in a mix of cash and highly liquid short-term investments. The goals of our investment policy are
preservation of capital, fulfillment of liquidity needs and fiduciary control of cash and investments. We also seek to maximize income from our investments without assuming significant risk.

Our primary exposure to market risk is interest income sensitivity, which is affected by changes in the general level of interest rates, particularly
because our investments are in short-term marketable securities. Due to the short-term duration of our investment portfolio and the low risk profile of our investments, an immediate 10% change in interest rates would not have a material effect on
the fair market value of our portfolio. Accordingly, we would not expect our operating results or cash flows to be affected to any significant degree by the effect of a sudden change in market interest rates on our securities portfolio.

As of March 31, 2008, our outstanding MLC Term Note has a fixed interest rate and therefore has minimal exposure to changes in interest rates.

Foreign Currency Risk

Most of our transactions are conducted in U.S. dollars, although we do have some development and clinical trial agreements with vendors located outside the U.S. Transactions under certain of these agreements are conducted in U.S. dollars
while others are transacted in the applicable local currency. The expenses and capital spending of our Canadian subsidiaries are transacted in Canadian dollars and subject to foreign exchange rate risk. Our foreign currency transactions are
translated into U.S. dollars at prevailing rates. Gains or losses resulting from foreign currency transactions are included in current period income or loss as incurred. All material transactions are denominated in U.S. dollars and we have not
entered into any material transactions that are denominated in foreign currencies. As a result, we do not believe that an immediate 10% change in the exchange rate applicable to our international business dealings would have a material impact on our
results of operations or cash flows.

Effects of Inflation

We do not believe that inflation and changing prices over the three months ended March 31, 2008 and 2007 had a significant impact on our results of
operations.



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|Item 4. | Controls and Procedures
|------- | -----------------------

Evaluation of Disclosure Controls and
Procedures

As required by Rule 13a15(b) of the Securities and Exchange Act of 1934, as amended (the 1934 Act), our
management, including the principal executive officer and the principal financial officer, conducted an evaluation as of the end of the period covered by this Quarterly Report on Form 10-Q of the effectiveness of the design and operation of our
disclosure controls and procedures. Based on that evaluation, our principal executive officer and principal financial officer concluded that our disclosure controls and procedures are effective at a reasonable assurance level in ensuring that
information required to be disclosed by us in the reports that we file or submit under the 1934 Act is recorded, processed, summarized and reported within the time periods specified in the SECs rules and forms. Disclosure controls and
procedures include, without limitation, controls and procedures designed to ensure that information required to be disclosed by us in the reports we file under the 1934 Act is accumulated and communicated to our management, including our principal
executive officer and principal financial officer, as appropriate to allow timely decisions regarding required disclosure.

Changes in Internal Control

As required by Rule 13a-15(d) of the 1934 Act, our management, including the principal executive officer and the principal financial
officer, conducted an evaluation of the internal control over financial reporting to determine whether any changes occurred during the period covered by this Quarterly Report on Form 10-Q that have materially affected, or are reasonably likely to
materially affect, our internal control over financial reporting. Based on that evaluation, the principal executive officer and principal financial officer concluded no such changes during the fiscal quarter covered by this Quarterly Report on Form
10-Q materially affected, or were reasonably likely to materially affect, our internal control over financial reporting.



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PART II. OTHER INFORMATION



|Item 1. | Legal Proceedings
|------- | -----------------

We are not currently a party to
any material legal proceedings.



|Item 1A. | Risk Factors
|-------- | ------------

Investment in our common stock
involves a high degree of risk and uncertainty. You should carefully consider each of the risks and uncertainties described below before you decide to invest in our common stock. You should also refer to the other information in this quarterly
report, including our financial statements and related notes. If any of the following risks and uncertainties actually occurs, our business, financial condition, and results of operations could be severely harmed. This could cause the market price
of our common stock to decline, and you could lose all or part of your investment.

Risks Related to our Business

We are dependent on the success of our lead product candidate, oritavancin, and we cannot give any assurance that it will receive regulatory approval, which is
necessary before it can be commercialized.

Our near-term prospects are substantially dependent on our ability to obtain FDA approval
to market our lead product candidate, oritavancin, and successfully commercialize this product should it gain approval. We submitted an NDA to the FDA in February 2008 seeking approval to commercialize oritavancin for the treatment of cSSSI. We will
not be able to commercialize oritavancin in the U.S. prior to obtaining FDA approval. Based on the timing of the submission of our NDA to the FDA, we would not expect to receive FDA approval and be able to commercialize this product until the fourth
fiscal quarter of 2008, at the earliest. We cannot assure you that we will be able to obtain FDA approval for this product. If we are not able to commercialize oritavancin for cSSSI or for any other indications, we will not be able to generate
product revenues in the foreseeable future, or at all. Oritavancin is the only one of our product candidates for which clinical trials have been conducted, and we do not expect to advance any other product candidates into clinical trials until 2009,
if at all.

We have limited experience conducting clinical trials, and no prior experience in submitting an NDA to the FDA seeking
regulatory approval to commercialize a drug. The two Phase 3 clinical trials that we have used in support of our NDA for oritavancin for cSSSI were conducted by our predecessors in the development of this drug. These two Phase 3 trials were designed
and conducted as non-inferiority studies in which oritavancin was compared with vancomycin followed by cephalexin, an approved treatment for patients who have serious gram-positive infections. The goal of a non-inferiority study, such as those
conducted with respect to oritavancin, is to show that a product candidate is not statistically less effective than the approved treatment.

Although our NDA has now been submitted to and accepted by the FDA for substantive review, it is possible that the FDA may conclude after review of our data that our application is insufficient to allow approval of oritavancin. If the FDA
does not approve our NDA, it may require that we conduct additional clinical, pre-clinical or manufacturing validation studies and submit those data before it will reconsider our application. Depending on the extent of these or any other
FDA-required studies, approval of any NDA or application that we submit may be delayed by several years, or may require us to expend more resources than we have available. In addition, increased scrutiny by the U.S. Congress of the FDAs
approval process may significantly delay or prevent regulatory approval, as well as impose more stringent product labeling and post-marketing testing requirements on pharmaceutical products generally, and particularly in our areas of focus. Any
delay in obtaining, or an inability to obtain, regulatory approvals would prevent us from commercializing oritavancin or any of our other product candidates, generating revenues, and achieving and sustaining profitability. It is also possible that
additional studies, if performed and completed, may not be considered sufficient by the FDA to approve our application. If any of these outcomes occurs, we may be forced to abandon our application for approval of oritavancin, which would materially
adversely affect our business and could potentially cause us to cease operations.



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We may experience significant delays in the commercial launch of oritavancin, which would delay our generation of
revenues.

We could experience significant delays in the commercial launch of oritavancin due to many factors, including:



| |  |  | any requirement by the FDA that we conduct additional studies to support our NDA or the denial by the FDA of our NDA submission;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------



| |  |  | the FDAs determination that the results from the additional toxicology testing that we performed on existing oritavancin drug product produced by Abbott
Laboratories (Abbott) and Catalent Pharma Solutions, Inc. (formerly Cardinal Health PTS, LLC) (Catalent), our current suppliers, are unsatisfactory;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | any requirement by the FDA that the drug product we use for commercial launch contain a reduced level of impurities, which could potentially render our existing
drug product inventory unusable for our planned commercial launch and would require us to expend considerable time and expense to replace that inventory for commercial launch, which may be impossible or cost-prohibitive;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | any issues raised by the FDA in connection with its pre-approval inspections of the manufacturing facilities of our contract manufacturing partners, which may
result in the FDAs refusal to approve oritavancin for commercial sale or may require additional manufacturing validation studies or restrictions on operations, any of which would be costly and time consuming and require further FDA review and
approval;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | any delay in commencing and completing further Phase 2 and Phase 3 clinical trials of oritavancin for other indications, including for the treatment of cSSSI with a
single, larger dose, which clinical trial is presently underway, or for the treatment of other indications;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the receipt of unsatisfactory or unexpected results from these further clinical trials, which could cause the FDA to require us to perform additional testing or to
deny applications that we intend to submit in the future for additional indications for oritavancin;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | a delay in filing required applications with foreign regulatory authorities and any requirement by a foreign regulatory authority that we conduct further clinical
trials in order to qualify our application for approval; and
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | our failure to establish a sales and marketing force in the time frame that we anticipate and/or any failure or delay in getting oritavancin listed on hospital and
third-party payor formularies.
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

Any one or a combination of these events could significantly delay, or even prevent, our
ability to commercialize oritavancin. If we are not successful in commercializing oritavancin, or if we are significantly delayed in doing so, our business, operating results and financial condition will be materially adversely affected.

Recent FDA and Congressional actions have led to uncertainty as to the standards for obtaining FDA approval of new drugs generally and new antibiotics
specifically, and we cannot assure you that the FDA will not either require us to meet new standards in order to obtain approval for commercial sale of oritavancin or require us to demonstrate to the FDAs satisfaction why trial results under
superseded standards are adequate.

In the field of antibiotics, the FDA typically requires either superiority or non-inferiority trial
designs depending on the specific indication for which the product candidate is seeking approval. In the context of the most serious and, if left untreated, potentially life-threatening infections (such as the infections oritavancin seeks to treat),
the FDA often determines that a non-inferiority trial design is appropriate. In 2006, the FDA, for certain types of antibiotics for certain less serious, typically self-resolving infections, refused to accept successfully completed non-inferiority
studies as the basis for approval. Instead, for some antibiotic products or trials involving comparator antibiotics, the FDA required placebo-controlled trials demonstrating the superiority of a drug candidate to placebo before considering approval.
Conducting placebo-controlled trials for antibiotics can be time-consuming, expensive, and difficult to complete. Both the FDA and institutional review boards have ethical concerns about requiring or approving placebo-controlled trials because these
trials would deny some participating patients (those receiving placebo) access to any antibiotic therapy during the course of the trial. Even if FDA and institutional review board approval is obtained, it may be difficult to enroll patients in
placebo-controlled trials, particularly for infections that are serious and, if left untreated, life-threatening, because certain patients would not receive antibiotic therapy. The FDA has not indicated whether all antibiotics would require
placebo-controlled superiority studies for FDA approval. This lack of guidance creates uncertainties about the standards for approval of antibiotics in the U.S.



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Moreover, recent events, including complications arising from FDA-approved drugs, have raised questions
about the safety of marketed drugs and may result in new legislation by the U.S. Congress and increased caution by the FDA and comparable foreign regulatory authorities in reviewing new drugs based on safety, efficacy or other regulatory concerns.
In particular, non-inferiority studies have come under scrutiny from Congress, in part because of a congressional investigation as to the safety of Ketek, an antibiotic approved by the FDA on the basis of non-inferiority studies. Certain key members
of Congress have asked the U.S. Government Accountability Office, an independent, non-partisan arm of Congress, to investigate the FDAs reliance on non-inferiority studies as a basis for approval. It is possible that members of Congress may
draft and introduce, and that Congress may pass, legislation that could significantly change the FDAs approval process for antibiotics. If this were to happen, the path to regulatory approval for oritavancin might be significantly delayed.

The FDA has confirmed to us in writing that clinical trials relying on a non-inferiority trial design, like the two Phase 3 clinical
trials conducted by our predecessors on oritavancin for cSSSI, are the appropriate type of trial design for the study of the safety and efficacy of oritavancin for the treatment of a serious and, if left untreated, life-threatening skin infection
like cSSSI. However, though we have not been asked to date to do so, we cannot assure you that the FDA will not require us to perform additional clinical trials to demonstrate the non-inferiority or superiority of oritavancin as compared either to
placebo or to previously approved treatments like vancomycin. In addition, we cannot assure you that the FDA will, when reviewing our NDA submission, consider the results of the two Phase 3 clinical trials of oritavancin sufficient.

If we cannot justify to the FDA the 15% non-inferiority margin used in the first Phase 3 study of oritavancin with respect to oritavancins benefit over placebo
and its non-inferiority to vancomycin and other approved antibiotics, the FDA may not approve oritavancin without an additional Phase 3 study or at all.

A clinical trial designed to demonstrate non-inferiority aims to demonstrate that, at its lower limit or bound, the experimental drug candidate had efficacy results that fell within an approved range, or
non-inferiority delta, relative to the efficacy results of the comparison drug (often referred to as the comparator or control arm of the trial). The first of the two Phase 3 studies of oritavancin for cSSSI conducted by our predecessors was
designed to demonstrate non-inferiority on a primary endpoint with a delta, or difference, in cure rate of not more than 15% between oritavancin and the comparator (vancomycin followed by cephalexin, an oral antibiotic). A 15% delta was appropriate
for this non-inferiority trial at the time the FDA reviewed the protocol design of this Phase 3 trial, which commenced in 1999. The results of this first Phase 3 trial demonstrated oritavancins efficacy at the lower bound with a 95%
probability of being not more than 14.8% less effective than the comparator arm, which was within the 15% non-inferiority delta for this trial. Although the trial results were within the then accepted 15% non-inferiority delta for this particular
clinical trial, new International Conference on Harmonization (ICH) guidelines now request the sponsor to provide a reliable estimate of the placebo-adjusted cure rate of the control treatment (in our case, vancomycin) in a population
similar to that enrolled in the trial, before selecting the non-inferiority margin. In our Pre-NDA meetings, the FDA noted that our retrospective justification of a 15% non-inferiority margin, based on the new ICH guidelines, would be a critical
element in its review of this Phase 3 clinical trial. In our recently filed NDA, in reliance on assembled scientific data from publications and previous studies, we applied the new ICH guidelines to support retrospectively the 15% non-inferiority
margin. If the FDA does not find the materials and information we submitted to be persuasive and sufficient to support approval of an NDA or does not find our justification for the use of a 15% non-inferiority delta compelling, we may be unable to
obtain FDA approval for oritavancin without additional clinical trials or at all. Any requirement of the FDA that we conduct an additional Phase 3 study of oritavancin would entail substantial expense and delay, and we cannot assure you in such a
case that oritavancin would ever receive FDA approval.

If we are unable to discover, develop or acquire product candidates that are safe and effective,
our business will be adversely affected.

We have never commercialized any of our product candidates. Further, we are uncertain whether
any of our product candidates will meet applicable regulatory standards or whether any of our product candidates other than oritavancin will prove safe and effective in humans. Companies in the biotechnology and pharmaceutical industries, including
companies with greater experience in pre-clinical testing and clinical trials than we have, have suffered significant setbacks in advanced clinical trials, even after demonstrating promising results in earlier trials. The risk of failure for all of
our product candidates is high. The data supporting our drug discovery and development programs is derived solely from laboratory experiments, pre-clinical studies and clinical studies. Further, we have limited experience conducting clinical trials,
and the two Phase 3 clinical trials that we used in support of the NDA we submitted to the FDA in February 2008 for oritavancin for cSSSI were conducted by our predecessors in the development of oritavancin. There can be no assurance that the Phase
3 clinical trials conducted by our predecessors included a sufficiently large population of patients to demonstrate safety and efficacy sufficient for the FDA to approve the dosage levels included in the product label within our NDA submission.



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We anticipate performing further clinical trials of oritavancin over the next several years in an effort
to establish its efficacy in other indications. Beyond oritavancin, our other compounds remain in the lead identification, lead optimization, pre-clinical testing and early clinical testing stages. It is, therefore, impossible to predict when or if
any of our other compounds and product candidates will prove effective or safe in humans or will receive regulatory approval.

In addition
to internal development, an element of our strategy is to seek to in-license other innovative antibiotic product candidates from third parties. Our success in executing on this strategy depends upon our ability to identify, select and acquire the
right product candidates and products on terms that are acceptable to us. Any product candidate we identify, license or acquire may require additional development efforts prior to commercial sale, including extensive clinical testing and approval by
the FDA and applicable foreign regulatory authorities.

If we are unable to discover, develop or acquire medicines that are effective and
safe in humans, our business will fail.

The development and testing of our product candidates are subject to extensive regulation, which can be costly
and time consuming. Any of our product candidates may encounter unanticipated delays or suffer significant setbacks or fail in later clinical studies.

Product candidates that have shown promising results in early pre-clinical or clinical studies may subsequently suffer significant setbacks or fail in later clinical studies. Clinical studies involving our product
candidates may reveal that those candidates are ineffective, inferior to existing approved medicines, unacceptably toxic or have other unacceptable side effects. Negative or inconclusive results from or adverse medical events during a clinical trial
could cause the clinical trial to be repeated or a program to be terminated, even if other studies or trials relating to the program are successful.

Clinical testing is expensive, can take many years to complete and its outcome is uncertain. Failure can occur at any time during the clinical trial process. Additionally, the time required to obtain approval by the
FDA is unpredictable, but typically takes many years following the commencement of clinical trials. If our clinical studies are substantially delayed or fail to prove the safety and effectiveness of our product candidates, we may not receive
regulatory approval of any of our product candidates, and our business, operating results and financial condition will be materially harmed.

Further, we must conduct our clinical trials under protocols that are acceptable to regulatory authorities and to the committees responsible for clinical studies at the hospital sites at which these studies are conducted. We may experience
delays in preparing protocols or receiving approval for them that may delay either or both the start and finish of our clinical trials. In addition, we may receive feedback from regulatory authorities or results from earlier stage clinical studies
that require modifications or delays in planned later stage clinical trials or that cause a termination or suspension of our drug development efforts. If we were to encounter any of these types of delays or suspensions, our drug development costs
would likely increase and the timeline for our receipt of regulatory approvals would likely be delayed.

We may be required to suspend or discontinue
clinical trials due to the occurrence of unacceptable side effects or other safety risks that could preclude or delay approval of our product candidates.

Our clinical trials may be suspended at any time for a number of reasons. We may voluntarily suspend or terminate our clinical trials if at any time we believe that they present an unacceptable risk to participants.
In addition, regulatory agencies may order the temporary or permanent discontinuation of our clinical trials at any time if they believe that the clinical trials are not being conducted in accordance with applicable regulatory requirements or that
they present an unacceptable safety risk to participants.

Many antibiotics produce significant side effects, including, for example,
severe allergic reaction, decreased blood pressure, suppression of the bone marrow, inflammation, swelling at the site of injection, muscle toxicity, optic and peripheral neuropathies and headaches. In clinical trials performed to date, side effects
of oritavancin have included nausea, vomiting, constipation, diarrhea, injection site phlebitis, headache, dizziness, insomnia, rash and histamine-like infusion reactions including itching, hives, flushing, redness, wheezing (sometimes with
shortness of breath), angioedema (or rapid swelling of the skin), hypotension, and muscle spasm. In addition, future clinical trials could reveal other side effects. The incidence of these or other side effects could cause us to interrupt, delay or
halt future clinical trials of our product candidates and could result in the FDA or other regulatory authorities stopping further development of or denying approval of our product candidates for any or all targeted indications. Even if we believe
our product candidates are safe, our data is subject to review by the FDA and comparable foreign regulatory authorities, which may disagree with our conclusions. Moreover, though we have clinical trial insurance, we could be subject to significant
liability if any volunteer or patient suffers, or appears to suffer, adverse health effects as a result of participating in one of our clinical trials.



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In 2004, InterMune, then the developer of oritavancin, requested a voluntary, self-imposed clinical hold
on oritavancin prior to completion of two Phase 1 studies (OCSI-007 and OCSI-008) that were performed to evaluate drug-drug interaction and QT interval prolongation. InterMune requested this self-imposed clinical hold in part due to the observance
of phlebitis, or vascular inflammation, at the infusion site judged to be unexpectedly greater in incidence and severity than anticipated. We have, since our acquisition of the rights to oritavancin from InterMune in December 2005, reexamined the
data from all of the clinical trials with oritavancin and determined that the incidence of phlebitis in the clinical trials of oritavancin for cSSSI was not substantially higher than found with treatment with vancomycin or other glycopeptides.
Further, we submitted our assessment of this data to the FDA and, at a January 2007 Pre-NDA meeting, the FDA accepted our assessment and agreed to lift the voluntary clinical hold on oritavancin, allowing us to complete three clinical trials with
oritavancin during 2007. Although we believe that we have satisfactorily resolved this safety concern, we cannot assure you that this historic safety concern or any other safety concerns will not result in significant delays in obtaining regulatory
approval of our NDA or in more stringent product labeling requirements for the cSSSI indication.

The regulatory approval process for our product
candidates is complex and costly. If oritavancin or the other product candidates that we develop are not approved by regulatory agencies, including the FDA, we will be unable to commercialize them.

Before we can launch our product candidates for commercial distribution, we must provide the FDA and similar foreign regulatory authorities with data
from pre-clinical and clinical studies that demonstrates that our product candidates are safe and effective for a defined indication. Our product candidates may face delays in receiving regulatory approval or may fail to receive regulatory approval
at all for many reasons, including the following:



| |  |  | approval policies, regulations, or the type and amount of clinical data necessary to gain approval may change;
| | - |  | --------------------------------------------------------------------------------------------------------------



| |  |  | we may be unable to demonstrate to the satisfaction of the FDA or comparable foreign regulatory authorities that a product candidate is safe and effective for a
particular indication;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the results of clinical trials may not meet the level of statistical significance required by the FDA or other regulatory authorities for approval;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the FDA or other regulatory authorities may disagree with the design of our clinical trials;
| | - |  | --------------------------------------------------------------------------------------------



| |  |  | we may be unable to demonstrate that a product candidates benefits outweigh its risks or that it presents an advantage over existing therapies, or over
placebo in any indications for which the FDA requires a placebo-controlled trial;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the FDA or comparable foreign regulatory authorities may disagree with our interpretation of data from pre-clinical studies or clinical trials, including our
assessment that the incidence of injection-site phlebitis in healthy volunteers in the clinical trials performed by our predecessors on oritavancin for cSSSI (which trials involved a higher dose of oritavancin than the one we will include in our
initial NDA submission for oritavancin) was not substantially higher than shown for approved treatment protocols like vancomycin and other glycopeptides;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the data collected from clinical trials of our product candidates may not be sufficient to support the submission of an NDA or to obtain regulatory approval in the
U.S. or elsewhere, or may only be sufficient under subsequently superseded regulatory requirements;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | we may encounter difficulty in maintaining contact with patients after treatment, resulting in incomplete clinical trial data;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------



| |  |  | we may face delays in patient enrollment and variability in the number and types of patients available for clinical studies;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------



| |  |  | clinical trials of our product candidates may result in adverse events, safety issues or side effects relating to our product candidates or their formulation into
medicines; and
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the FDA or comparable foreign regulatory authorities may fail to approve the manufacturing processes or facilities of manufacturers with which we contract for
clinical and commercial supplies.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

We will not obtain regulatory approval for a product candidate in the U.S. unless and
until the FDA approves an NDA. In order to market our medicines outside of the U.S., we must obtain separate regulatory approval in each country. However, in the European Union (E.U.), we intend to pursue regulatory approval through the
centralized approval process, which, if successful, would lead to simultaneous approval in all 27 E.U. member states. The approval procedure varies among countries and can involve additional testing. Further, the time required to obtain approval
from foreign regulatory authorities may differ from that required to obtain FDA approval. Approval by the FDA does not ensure approval by regulatory authorities in other countries, and approval by one foreign regulatory authority does not ensure
approval by regulatory authorities in other foreign countries or by the FDA. Satisfaction of these and other regulatory requirements is costly, time consuming, uncertain and subject to unanticipated delays. We submitted an NDA to the FDA for
oritavancin in February 2008 and have not made a comparable submission in any foreign country for any of our product candidates, including oritavancin.



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The FDA or comparable foreign regulatory authorities might decide that our data is insufficient for
approval and require additional clinical trials or other studies. Additionally, recent events have raised questions about the safety of marketed drugs and may result in increased cautiousness by the FDA and/or comparable foreign regulatory
authorities in reviewing new drugs based on safety, efficacy or other regulatory considerations. Further, the FDA and comparable foreign regulatory authorities may decelerate regulatory approvals for new drug candidates and impose more stringent
product labeling requirements in an effort to ensure that approved drugs are safe and efficacious. Any delay in obtaining, or any inability to obtain, applicable regulatory approvals would prevent us from commercializing our product candidates.
Further, even if we do receive regulatory approval to market a commercial product, that approval may be subject to limitations on the indicated uses for the approved drug product. It is possible that none of our existing product candidates or any
product candidates we may seek to develop in the future will ever obtain the necessary regulatory approvals for commercialization.

Oritavancin may not
be accepted by physicians, patients, third-party payors, or the medical community in general.

Even if oritavancin is approved by the
relevant regulatory agencies, the commercial success of oritavancin will depend upon its acceptance by physicians, patients, third-party payors and the medical community in general. If approved, oritavancin will compete with vancomycin, a relatively
inexpensive generic drug that is manufactured by a variety of companies, a number of existing antibiotics manufactured and marketed by major pharmaceutical companies and others, including linezolid (marketed by Pfizer Inc. (Pfizer) as
Zyvox) and daptomycin (marketed by Cubist Pharmaceuticals, Inc. (Cubist Pharmaceuticals) as Cubicin), and potentially new antibiotics that are not yet on the market. Even if the medical community accepts that oritavancin is safe and
efficacious for its approved indications, physicians may not immediately be receptive to the use of oritavancin or may be slow to adopt it as an accepted treatment for gram-positive infections. Moreover, in the future, as has happened with other
antibiotics (including vancomycin), infectious bacteria could develop resistance to oritavancin, particularly if it becomes widely used, which would render it less effective and therefore less appealing to physicians. In the U.S. and elsewhere,
sales of pharmaceutical products depend in significant part on the availability of coverage and reimbursement to providers and the consumer from third-party payors, such as government and private insurance plans. These third-party payors are
increasingly challenging and negotiating the prices charged for medical products and services based on their degree of value to the patient. If not added to hospital and third-party payor formularies, oritavancin will not be available for
prescription by treating physicians.

If we are unable to demonstrate to physicians that, based on experience, clinical data, side-effect
profiles and other factors, oritavancin is preferable to vancomycin and other existing or subsequently developed anti-infective drugs, we may never generate meaningful revenue from oritavancin. The degree of market acceptance of oritavancin depends
on a number of factors, including, but not limited to:



| |  |  | the demonstrated clinical efficacy and safety of oritavancin;
| | - |  | -------------------------------------------------------------



| |  |  | our ability to educate the medical community about the safety and effectiveness of oritavancin;
| | - |  | -----------------------------------------------------------------------------------------------



| |  |  | the cost of treatment using oritavancin in relation to alternative treatments, including vancomycin and other generic antibiotics;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



| |  |  | acceptance by physicians and patients of oritavancin as a safe and effective treatment;
| | - |  | ---------------------------------------------------------------------------------------



| |  |  | the extent to which oritavancin is approved for inclusion on formularies of hospitals and third-party payors;
| | - |  | -------------------------------------------------------------------------------------------------------------



| |  |  | the reimbursement policies of government and third-party payors;
| | - |  | ----------------------------------------------------------------



| |  |  | the perceived advantages of oritavancin over alternative treatments, including its potency, treatment period and side effects as compared to alternative treatments;
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the clinical indications for which oritavancin is approved and whether oritavancin is effective against a broad range of gram-positive infections or only certain
ones;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the extent to which bacteria develop resistance to oritavancin, thereby limiting its efficacy in treating or managing infections;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------



| |  |  | whether oritavancin is designated under physician treatment guidelines as a first-line therapy or as a second- or third-line therapy for particular infections;
| | - |  | ---------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | relative convenience and ease of administration; and
| | - |  | ----------------------------------------------------



| |  |  | prevalence and severity of side effects.
| | - |  | ----------------------------------------



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We have incurred operating losses in each year since our inception and expect to continue to incur substantial losses
for the foreseeable future.

We have been engaged in discovering and developing compounds and product candidates since May 1997. We
only acquired worldwide rights to oritavancin from InterMune in December 2005. To date, we have not generated any product sales revenue from oritavancin or any drug product candidate, and we may never generate revenue from selling pharmaceutical
products. Further, even if we are able to commercialize oritavancin or another product candidate, there can be no assurance that we will ever achieve profitability. As of March 31, 2008, we had a deficit accumulated during the development stage
of approximately $144.6 million.

Assuming we obtain FDA approval for oritavancin in the treatment of cSSSI, we expect that our expenses
will increase as we prepare for the commercial launch of oritavancin and as we conduct further clinical trials on oritavancin for other indications. We also expect that our research and development expenses will continue to increase as we continue
to initiate new discovery programs and expand our development programs. As a result, we expect to continue to incur substantial losses for the foreseeable future, and these losses may be increasing. We are uncertain when or if we will be able to
achieve or sustain profitability. Failure to become and remain profitable would adversely affect the price of our common stock and our ability to raise capital and continue operations.

If we are unable to generate revenues from any product candidates, including oritavancin, or if we are unable to cost-effectively acquire other drug candidates or drug products, our ability to create long-term
stockholder value may be limited.

We have no drug products that have been approved by the FDA. Our product candidate closest to
possible commercialization is oritavancin, for which we filed an NDA with the FDA in February 2008 and for which we must still receive regulatory approval prior to commercial launch. We do not have any product candidates that will generate revenues
in the near term. We note that most drug candidates never make it to the clinical development stage and even those that do make it into clinical development have only a small chance of gaining regulatory approval and becoming approved drug products.
If we are unable to commercialize any of our current or future drug candidates, including oritavancin, or to acquire any marketable drug products, our ability to create long-term stockholder value will be limited.

In the future, we may seek out opportunities to partner with other companies to acquire rights to other drug candidates or drug products, but there is no
guarantee that we will be successful in these efforts. The market to acquire rights to promising drug candidates and drug products is highly competitive, and we would be competing with companies that have significantly more resources and experience
than we have. In addition, proposing, negotiating, completing and integrating an economically viable drug product acquisition or license can be a lengthy, complex and expensive process. We may not be able to acquire or license the rights to
additional product candidates and approved products on terms that we find acceptable, or at all.

We face significant competition from other
biotechnology and pharmaceutical companies and our operating results will suffer if we fail to compete effectively.

The biotechnology
and pharmaceutical industries are intensely competitive. We have competitors both in the U.S. and internationally, including major multinational pharmaceutical companies, biotechnology companies and universities and other research institutions. Many
of our competitors have greater financial and other resources, such as larger research and development staff and more experienced marketing and manufacturing organizations. Our competitors may succeed in developing, acquiring or licensing on an
exclusive basis technologies and drug products that are more effective or less costly than oritavancin or any drug candidate that we are currently developing or that we may develop, which could render our technology obsolete and noncompetitive.

The competition in the market for therapeutic products that address infectious diseases is intense. Oritavancin faces competition in the
U.S. from commercially available drugs such as vancomycin, marketed generically by Abbott, Shionogi & Co., and others; daptomycin, marketed by Cubist Pharmaceuticals as Cubicin; and linezolid, marketed by Pfizer as Zyvox. In particular,
vancomycin has been a widely used and well known antibiotic for over 40 years and is sold in a relatively inexpensive generic form. Vancomycin, daptomycin and linezolid are all approved treatments for serious gram positive infections such as cSSSI.
Further, daptomycin is an approved treatment for bacteremia and right-sided infective endocarditis, linezolid is an approved treatment for nosocomial pneumonia and vancomycin is an approved treatment for both bacteremia and pneumonia.



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In addition, Pfizer is seeking FDA approval to market dalbavancin in the U.S., and, according to filings
made with the SEC, Pfizer received an Approvable letter for dalbavancin in December 2007. Further, according to filings made by Theravance, Inc. (Theravance) with the SEC, Theravance received a letter from the FDA in October 2007
indicating that its NDA for telavancin was approvable, subject to resolution of certain current good manufacturing practices (cGMP) issues related to telavancin at a third-party manufacturer and submission of revised labeling or
re-analyses of clinical data or additional clinical data. Subsequently, in separate press releases and filings with the SEC in March 2008, Theravance announced, first, that the FDA had cancelled a planned review of telavancin by the Anti-Infective
Drugs Advisory Committee and, second, that the FDA had accepted as complete for review Theravances response to the October 2007 Approvable letter. Additionally, Theravance announced in filings with the SEC that its Prescription Drug User Fee
Act (PDUFA) date for telavancin is July 21, 2008. Other drug candidates in development include ceftobiprole (developed by Johnson & Johnson), for which the FDA recently issued an Approvable letter, and iclaprim (developed
by Arpida Ltd. (Arpida)), for which Arpida announced on March 19, 2008 that an NDA had been filed with the FDA. If approved, these drugs would compete in the intravenous antibiotic market and would target indications such as cSSSI.
In addition, oritavancin may face competition from drug candidates currently in clinical development and drug candidates that could receive regulatory approval before oritavancin in countries outside the U.S. and the E.U.

Our ability to compete successfully will depend largely on our ability to leverage our experience in drug discovery and development to:



| |  |  | discover and develop medicines that are superior to other products in the market;
| | - |  | ---------------------------------------------------------------------------------



| |  |  | attract qualified scientific, product development and commercial personnel;
| | - |  | ---------------------------------------------------------------------------



| |  |  | obtain patent and/or other proprietary protection for our medicines and technologies;
| | - |  | -------------------------------------------------------------------------------------



| |  |  | obtain required regulatory approvals; and
| | - |  | -----------------------------------------



| |  |  | successfully collaborate with pharmaceutical companies in the discovery, development and commercialization of new medicines.
| | - |  | ----------------------------------------------------------------------------------------------------------------------------

Any new medicine that competes with a generic market-leading medicine must demonstrate compelling advantages in efficacy, convenience, tolerability
and/or safety in order to overcome severe price competition and be commercially successful. If approved, oritavancin must demonstrate these advantages, as it will compete with vancomycin, a relatively inexpensive generic drug that is manufactured by
a number of companies, and a number of existing antibiotics marketed by major pharmaceutical companies. We will not achieve our business plan if the acceptance of oritavancin is inhibited by price competition or the reluctance of physicians to
switch from existing drug products to oritavancin or if physicians switch to other new drug products, or choose to reserve oritavancin for use in limited circumstances. The inability to compete with existing drug products or subsequently introduced
drug products would have a material adverse impact on our operating results.

Established pharmaceutical companies may invest heavily to
accelerate discovery and development of novel compounds or to in-license novel compounds that could make our product candidates obsolete. Accordingly, our competitors may succeed in obtaining patent protection, receiving FDA approval or discovering,
developing and commercializing medicines before we do. We are also aware of other companies that may currently be engaged in the discovery of medicines that will compete with the product candidates that we are developing.

Reimbursement may not be available for oritavancin or our other product candidates, which could make it difficult for us to sell our products profitably.

Market acceptance and sales of oritavancin or our other product candidates will depend on reimbursement policies and may be affected
by future healthcare reform measures. Government authorities and third-party payors, such as private health insurers and health maintenance organizations, decide which drugs they will pay for and establish reimbursement levels. We cannot be sure
that reimbursement will be available for oritavancin or any of our other product candidates. Also, we cannot be sure that reimbursement amounts will not reduce the demand for, or the price of, our products. If reimbursement is not available or is
available only to limited levels, we may not be able successfully to commercialize oritavancin or any of our other products.

In both the
U.S. and certain foreign jurisdictions, there have been a number of legislative and regulatory changes to the health care system that could impact our ability to sell our products profitably. In particular, the Medicare Modernization Act of 2003
revised the payment methodology for many injectable and infused products under Medicare. This has resulted in lower rates of reimbursement. There have been numerous other federal and state initiatives designed to reduce payment for pharmaceuticals.



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As a result of legislative proposals and the trend towards managed health care in the U.S., third-party
payors are increasingly attempting to contain health care costs by limiting both coverage and the level of reimbursement of new drugs. They may also refuse to provide any coverage of uses of approved products for medical indications other than those
for which the FDA has granted market approvals. As a result, significant uncertainty exists as to whether and how much third-party payors will reimburse patients for their use of newly approved drugs, which in turn will put pressure on the pricing
of drugs. The availability of numerous generic antibiotics at lower prices than branded antibiotics, such as oritavancin, if it were approved for commercial introduction, may also substantially reduce the likelihood of reimbursement for oritavancin.
We expect to experience pricing pressures in connection with the sale of our products due to the trend toward managed health care, the increasing influence of health maintenance organizations and additional legislative proposals.

Our ability to pursue the development and commercialization of oritavancin depends upon the continuation of our license from Lilly.

Our license agreement with Lilly provides us with a worldwide exclusive license to develop and sell oritavancin in fields relating to infectious
diseases. Pursuant to the license agreement, we are required to make certain milestone and royalty payments to Lilly. The license rights to oritavancin granted to us could revert to Lilly if we do not continue to use commercially reasonable efforts
to develop and commercialize an oritavancin drug product or if we otherwise materially breach the agreement. In addition, either we or Lilly may terminate the license agreement upon the other partys insolvency or uncured material breach of the
agreement. If our license agreement with Lilly were terminated, we would lose our rights to develop and commercialize oritavancin, which would materially and adversely affect our business, results of operations and future prospects.

Even if our product candidates receive regulatory approval, commercialization of these products may be adversely affected by regulatory actions.

Even if we receive regulatory approval, this approval may include limitations on the indicated uses for which we can market our medicines. Further, if we
obtain regulatory approval, a marketed medicine and its manufacturer are subject to continual review, including review and approval of manufacturing facilities. Discovery of previously unknown problems with a medicine may result in restrictions on
its permissible uses, or on the manufacturer, including withdrawal of the medicine from the market. The FDA and similar foreign regulatory bodies may also implement new standards or change their interpretation and enforcement of existing standards
and requirements for the manufacture, packaging or testing of products at any time. If we are unable to comply, we may be subject to regulatory or civil actions or penalties that could significantly and adversely affect our business. Any failure to
maintain regulatory approval will limit our ability to commercialize our product candidates, which would materially and adversely affect our business, operating results and financial condition.

We rely on third parties to conduct our clinical trials. If these third parties do not successfully carry out their contractual duties or meet expected deadlines, we
may not be able to obtain regulatory approval for or commercialize our product candidates.

We have agreements with third-party
contract research organizations (CROs) to provide monitors for and to manage data for our ongoing clinical programs. We rely heavily on these parties for execution of our pre-clinical and clinical studies, and control only certain
aspects of their activities. Nevertheless, we are responsible for ensuring that each of our studies is conducted in accordance with the applicable protocol. We and our CROs are required to comply with current good clinical practices
(cGCP), which are regulations and guidelines enforced by the FDA for all of our products in clinical development. The FDA enforces these cGCP regulations through periodic inspections of trial sponsors, principal investigators and trial
sites. If we or our CROs fail to comply with applicable cGCP regulations, the clinical data generated in our clinical trials may be deemed unreliable and the FDA may require us to perform additional clinical trials before approving our marketing
applications. We cannot assure you that, upon inspection, the FDA will determine that any of our clinical trials comply with cGCP regulations. In addition, our clinical trials must be conducted with product produced under cGMP regulations, and will
require a large number of test subjects. Our failure to comply with these regulations may require us to repeat clinical trials, which would delay the regulatory approval process.

Our CROs have the right to terminate their agreements with us in the event of an uncured material breach. In addition, some of our CROs have an ability
to terminate their respective agreements with us if it can be reasonably demonstrated that the safety of the subjects participating in our clinical trials warrants such termination, if we make a general assignment for the benefit of our creditors or
if we are liquidated.



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If any of our relationships with these third-party CROs terminate, we may not be able to enter into
arrangements with alternative CROs. If CROs do not successfully carry out their contractual duties or obligations or meet expected deadlines, if they need to be replaced or if the quality or accuracy of the clinical data they obtain is compromised
due to the failure to adhere to our clinical protocols, regulatory requirements or for other reasons, our clinical trials may be extended, delayed or terminated and we may not be able to obtain regulatory approval for or successfully commercialize
our product candidates. As a result, our financial results and the commercial prospects for our product candidates would be harmed, our costs could increase and our ability to generate revenue could be delayed.

We have recently hired additional CROs to obtain additional resources and expertise to accelerate our progress with regard to on-going clinical programs
and the synthesis of clinical trial data for submission with our recently submitted NDA for oritavancin. Switching or adding additional CROs involves substantial cost and requires extensive management time and focus. In addition, there is a natural
transition period when a new contract research organization commences work. As a result, delays occur, which can materially impact our ability to meet our desired clinical development timelines. Though we carefully manage our relationships with our
CROs, there can be no assurance that we will not encounter similar challenges or delays in the future or that these delays or challenges will not have a material adverse impact on our operating results, financial condition or future prospects.

We will be completely dependent on third parties to manufacture oritavancin, and our commercialization of oritavancin could be stopped, delayed or made
less profitable if those third parties fail to provide us with sufficient quantities of oritavancin or fail to do so at acceptable quality levels or prices.

We do not have the capability to manufacture our own oritavancin active pharmaceutical ingredient (API). As a result, we have entered into a manufacturing and supply agreement with Abbott to manufacture
and supply us with bulk oritavancin API for clinical and commercial purposes. Abbott is our sole provider of our supply of oritavancin API. Pursuant to our agreement with Abbott, Abbott currently stores some oritavancin API at its facilities in
Illinois and the FDA has agreed to consider the use by us of oritavancin API produced by Abbott, upon regulatory approval, for commercial launch. It is possible, however, that if and when we receive regulatory approval to market and sell
oritavancin, our current supply of oritavancin API may have exceeded its useful life and no longer be appropriate for commercial sale.

In
addition, we do not have the capability to package oritavancin finished drug product for distribution to hospitals and other customers. Consequently, we have entered into an agreement with Catalent to supply us with finished product, to be packaged
100 milligrams in 20 cc vials. Prior to commercial launch, we intend to enter into a similar agreement with an alternate fill/finish drug product supplier for oritavancin so that we can ensure proper supply chain management once we are authorized to
make commercial sales of oritavancin. Once finalized, we expect that the selected alternate supplier will provide us with finished drug product, also packaged 100 milligrams in a 20 cc vial. If we receive marketing approval from the FDA, we intend
to sell drug product finished and packaged by either Catalent or this alternate supplier.

We have entered into long-term agreements with
each of Abbott and Catalent. In the case of the agreement with Abbott, either party to this agreement may terminate the agreement with at least two years advance notice if the terminating party determines in good faith that the clinical development
and/or commercialization of oritavancin of the bulk drug substance, before or after the first commercial sale made by us, is not technically or commercially feasible or if it is not economically justifiable. After the initial term of this agreement,
which extends until December 31, 2014, the agreement automatically renews for successive two-year terms unless terminated by either party with at least twelve months notice. If we change the specifications for the bulk drug substance
Abbott is to produce, or the FDA or another regulatory body requires us to change the manufacturing specification for the bulk drug substance, and that change would increase Abbotts manufacturing costs, we must reach an agreement with Abbott
about how to allocate the costs associated with the change. If we cannot reach agreement, Abbott may refuse to implement the change, or may terminate the agreement. Further, Abbott may terminate this agreement if the FDA has not approved an NDA for
oritavancin prior to January 1, 2010. Finally, either we or Abbott may terminate this agreement on 60 days written notice in the event of insolvency of or uncured material breach by the other party.

Our agreement with Catalent provides for an initial three-year term continuing until March 27, 2010. Either party may terminate this agreement on 60
days written notice in the event of an uncured material breach. In addition, Catalent may suspend production under this agreement until any outstanding payments are brought current. Finally, either party may terminate this agreement upon the
other partys insolvency. We have not yet entered into a long-term agreement with any alternate fill/finish suppliers, but we intend to do so prior to commercial launch of oritavancin in order to ensure that we maintain adequate supplies of
finished drug product.



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If, for any reason, these third parties are unable or unwilling to perform, we may not be able to
terminate our agreements with them, and we may not be able to locate alternative manufacturers or formulators or enter into favorable agreements with them. If Catalent or any alternate supplier of finished drug product, or, Abbott, our drug
substance or API supplier, experiences any significant difficulties in its respective manufacturing processes for oritavancin API or finished product, we could experience significant interruptions in the supply of oritavancin. We note that in 2007,
in connection with the production of a series of three validation lots, two of the manufacturing lots failed to meet the required specifications such that they had to be reproduced. Were we to encounter manufacturing issues such as this on a larger
scale in the future, our ability to produce a sufficient supply of oritavancin might be negatively affected. Our inability to coordinate the efforts of our third-party manufacturing partners, or the lack of capacity available at our third-party
manufacturing partners, could impair our ability to supply oritavancin at required levels. Because of the significant regulatory requirements that we would need to satisfy in order to qualify a new bulk or finished product supplier, if we face these
or other difficulties with our current suppliers, we could experience significant interruptions in the supply of oritavancin if we decided to transfer the manufacture of oritavancin to one or more alternative suppliers in an effort to deal with the
difficulties.

We cannot guarantee that Abbott, Catalent or alternative manufacturers will be able to reduce the costs of commercial scale
manufacturing of oritavancin over time. If the manufacturing costs of oritavancin remain at current levels, these costs may significantly impact our operating results. In order to reduce costs, we may need to develop and implement process
improvements. However, in order to do so, we will need, from time to time, to notify or make submissions with regulatory authorities, and the improvements may be subject to approval by such regulatory authorities. We cannot be sure that we will
receive these necessary approvals or that these approvals will be granted in a timely fashion. We also cannot guarantee that we will be able to enhance and optimize output in our commercial manufacturing process. If we cannot enhance and optimize
output, we may not be able to reduce our costs over time.

We believe we have sufficient quantities of bulk drug substance and have
contracted with Catalent to formulate finished drug product to complete all of the currently planned clinical studies of oritavancin. Further, we plan to have Abbott, Catalent and any alternate suppliers later identified, manufacture and package
additional bulk drug substance and finished drug product in connection with commercial launch in the event oritavancin is approved for sale by regulatory authorities. If we are unable to do so in a timely manner, the commercial introduction of
oritavancin, if approved by the FDA, would be adversely affected.

If the FDA does not approve the manufacturing facilities of Abbott, Catalent or any
later identified manufacturing partners, we may be unable to develop or commercialize oritavancin.

We rely on Abbott and Catalent to
manufacture bulk oritavancin API and finished drug product, respectively, and currently have no plans to develop our own manufacturing facility. In addition, we expect to add an alternate fill/finish provider prior to commercial launch of
oritavancin. The facilities used by our contract manufacturers to manufacture our product candidates must be inspected and approved by the FDA, which inspections will commence in the coming months in light of the February 2008 submission of our NDA
to the FDA. We do not control the manufacturing process of oritavancin and are completely dependent on our contract manufacturing partnerscurrently, Abbott and Catalentfor compliance with the FDAs requirements for manufacture of
finished oritavancin drug product. If our contract manufacturers cannot successfully manufacture material that conforms to our specifications and the FDAs strict regulatory requirements, they will not be able to secure FDA approval for the
manufacturing facilities. If the FDA does not approve these facilities for the manufacture of oritavancin, we may need to find alternative manufacturing facilities, which would result in significant delays of up to several years in obtaining
approval for and manufacturing oritavancin.

In addition, our contract manufacturers will be subject to ongoing periodic unannounced
inspections by the FDA and corresponding state and foreign agencies for compliance with the cGMP regulations, and similar regulatory requirements. These cGMP regulations cover all aspects of the manufacturing, testing, quality control and record
keeping relating to our product candidates. We do not have control over our contract manufacturers compliance with these regulations and standards. Failure by any of our contract manufacturers to comply with applicable regulations could result
in sanctions being imposed on us, including fines, injunctions, civil penalties, failure to grant approval to market our product candidates, delays, suspensions or withdrawals of approvals, operating restrictions and criminal prosecutions, any of
which could significantly and adversely affect our business. In addition, we have no control over the ability of our contract manufacturers to maintain adequate quality control, quality assurance and qualified personnel. Failure by our contract
manufacturers to comply with or maintain any of these standards could adversely affect our ability to have produced, obtain regulatory approval for or market our product candidates.



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In order to satisfy regulatory authorities, we may need to reformulate the way in which our oritavancin API is created
to remove animal source product.

Presently, our oritavancin API is manufactured using animal-sourced productsnamely
porcine-sourced products. Certain non-U.S. regulatory authorities have historically objected to the use of animal-sourced productsparticularly bovine-sourced productsduring the preparation of finished drug product. As a result and in
order to best position oritavancin for approval in foreign jurisdictions, we have entered into an agreement with Abbott whereby we, along with Abbott, are seeking to develop a manufacturing process for oritavancin API that does not rely on the use
of any animal-sourced products.

Although we believe that we can develop a manufacturing process for oritavancin API that does not rely on
the use of animal-sourced product, there can be no assurance that we, along with Abbott, will be successful in this endeavor. If we are unable to remove animal-sourced product from the manufacturing process for oritavancin API, it is possible that
we will be unable to receive regulatory authority for oritavancin in certain foreign jurisdictions, which would likely have a negative impact on our ability to achieve our business objectives.

We may encounter delays in filling customer orders or incur substantial losses if our supply of bulk and finished drug product, which are produced and packaged for us
by third-party manufacturers, is interrupted.

Once Abbott has completed production of oritavancin bulk drug substance at its
facilities in Illinois, the material is shipped to Catalents facilities in Arizona for processing, packaging and labeling as final drug product. These shipments are of significant value and, while in transit, could be lost or damaged.
Moreover, at any time after being shipped, our oritavancin API or finished drug product could be lost or damaged as it is stored with Catalent, our current finished product manufacturer, or, additionally, in the future, when it is stored at the
facilities of any alternate fill/finish supplier. Depending on when in this process the API or finished drug product is lost or damaged, we may have limited recourse for recovery from our manufacturers or insurers. As a result, our financial
performance could be impacted by any such loss of or damage to our oritavancin API.

We also may experience interruption or significant
delay in the supply of oritavancin API or finished drug product due to natural disasters, acts of war or terrorism, shipping embargoes, labor unrest or political instability. In any such event, the supply of oritavancin API stored at Abbott and the
oritavancin finished drug product stored with Catalent or any alternate fill/finish supplier could also be impacted. We may also be subject to financial risk from volatile fuel costs associated with shipping oritavancin API or finished drug product
within the U.S. and, once we have received necessary foreign approvals, to our international distribution partners for packaging, labeling and distribution.

If we fail to obtain the capital necessary to fund our operations, we may be unable to develop our product candidates and we could be forced to share our rights to commercialize our product candidates with third parties on terms that may
not be favorable to us.

We need large amounts of capital to support our research and development efforts. If we are unable to secure
capital to fund our operations, we will not be able to continue our discovery and development efforts and we might have to enter into strategic collaborations that could require us to share commercial rights to our products and product candidates
with third parties in ways that we currently do not intend. Based on our current operating plans, we believe that our cash, cash equivalents and short-term investments will be sufficient to meet our anticipated operating needs into the third quarter
of 2009. Depending on the status of regulatory approval or, if approved, commercialization of oritavancin, as well as the progress we make in selling that product candidate, we may require additional capital to fund operating needs thereafter.

Further, we are party to a license agreement with Lilly pursuant to which we are obligated to make certain cash milestone payments to
Lilly upon the receipt of certain regulatory approvals of our oritavancin product. In addition, we are required to make certain cash royalty payments upon our achievement of target levels of commercial sales of our oritavancin product. We are also
obligated to make a future cash milestone payment to InterMune upon our receipt from the FDA of all approvals necessary for the commercial launch of oritavancin. Though we believe that these royalty rates and milestone payments are reasonable in
light of our business plan, we will require large amounts of capital to satisfy these obligations.



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We may also need to raise additional funds sooner if we choose to expand more rapidly than we presently
anticipate. To raise additional funds, we may seek to sell additional equity or debt securities, or both, or incur other indebtedness. Further, under the terms of our credit agreement with Merrill Lynch Capital and two other lenders, we may not
incur additional indebtedness in excess of $250,000 without Merrill Lynch Capitals prior written consent. The sale of additional equity or debt securities, if convertible, could result in the issuance of additional shares of our capital stock
and could result in dilution to our stockholders. The incurrence of indebtedness would result in increased fixed payment obligations and could also result in certain restrictive covenants, such as limitations on our ability to incur additional debt,
limitations on our ability to acquire or license intellectual property rights and other operating restrictions that could adversely impact our ability to conduct our business. We cannot guarantee that future financing will be available in sufficient
amounts or on terms acceptable to us, if at all. If we are unable to raise additional capital in sufficient amounts or on terms acceptable to us, we will be prevented from pursuing research and development efforts. This could harm our business,
operating results and financial condition and cause the price of our common stock to fall.

If we are unable to establish satisfactory sales and
marketing capabilities, we may not succeed in commercializing oritavancin.

In anticipation of receiving FDA approval for the
commercial launch of oritavancin, we hired a Chief Commercial Officer in March 2008 and anticipate beginning to hire additional sales and marketing personnel to establish our own sales and marketing capabilities in the U.S. in time for our
anticipated commercial launch of oritavancin. We plan to add our first sales representatives after we receive FDA approval of our NDA for oritavancin in cSSSI. Therefore, at the time of our anticipated commercial launch of oritavancin, assuming
regulatory approval of the drug by the FDA, our sales and marketing team will have worked together for only a limited period of time. We cannot guarantee that we will be successful in marketing oritavancin in the U.S.

We may not be able to establish a direct sales force in a cost effective manner or realize a positive return on this investment. In addition, we will
have to compete with other pharmaceutical and biotechnology companies to recruit, hire, train and retain sales and marketing personnel. Factors that may inhibit our efforts to commercialize our products without strategic partners or licensees
include:



| |  |  | our inability to recruit and retain adequate numbers of effective sales and marketing personnel;
| | - |  | ------------------------------------------------------------------------------------------------



| |  |  | the inability of sales personnel to obtain access to or persuade adequate numbers of physicians to prescribe our products;
| | - |  | --------------------------------------------------------------------------------------------------------------------------



| |  |  | the lack of complementary products to be offered by sales personnel, which may put us at a competitive disadvantage relative to companies with more extensive
product lines; and
| | - |  | --------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | unforeseen costs and expenses associated with creating an independent sales and marketing organization.
| | - |  | -------------------------------------------------------------------------------------------------------

If appropriate regulatory approvals are obtained, we intend to commercialize oritavancin and our other product candidates in international markets
through collaboration arrangements with third parties. We have not yet entered into any agreements related to the marketing of oritavancin or any of our other product candidates in international markets and we may not be able to enter into any
arrangements with respect to international collaborations on favorable terms or at all. In addition, these arrangements could result in lower levels of income to us than if we marketed our product candidates entirely on our own. If we are unable to
enter into appropriate marketing arrangements for our product candidates in international markets, we may not be able to develop an effective international sales force to commercialize oritavancin and our other product candidates in international
markets. If we fail to enter into marketing arrangements for our products and are unable to develop an effective international sales force, our ability to generate revenue would be limited as a significant portion of the market opportunity for
oritavancin and our other product candidates is likely to be in international markets.

If we are not successful in recruiting sales and
marketing personnel or in building a sales and marketing infrastructure or if we do not successfully enter into appropriate collaboration arrangements with third parties, we will have difficulty commercializing oritavancin and our other product
candidates, which would adversely affect our business, operating results and financial condition.



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A variety of risks associated with our international operations could materially adversely affect our business.

If approved for commercialization, we expect oritavancin to be marketed worldwide. Consequently, we expect that we will be subject to
additional risks related to operating in foreign countries including:



| |  |  | differing regulatory requirements for drug approvals in foreign countries;
| | - |  | --------------------------------------------------------------------------



| |  |  | the potential for so-called parallel importing, which is what happens when a local seller, faced with high or higher local prices, opts to import goods from a
foreign market (with low or lower prices) rather than buying them locally;
| | - |  | -----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | unexpected changes in tariffs, trade barriers and regulatory requirements;
| | - |  | --------------------------------------------------------------------------



| |  |  | economic weakness, including inflation or political instability in particular foreign economies and markets;
| | - |  | ------------------------------------------------------------------------------------------------------------



| |  |  | compliance with tax, employment, immigration and labor laws for employees living or traveling abroad;
| | - |  | -----------------------------------------------------------------------------------------------------



| |  |  | foreign taxes, including withholding of payroll taxes;
| | - |  | ------------------------------------------------------



| |  |  | foreign currency fluctuations, which could result in increased operating expenses and reduced revenues, and other obligations incident to doing business in another
country;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | workforce uncertainty in countries where labor unrest is more common than in the U.S.;
| | - |  | --------------------------------------------------------------------------------------



| |  |  | production shortages resulting from any events affecting raw material supply or manufacturing capabilities abroad; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------



| |  |  | business interruptions resulting from geo-political actions, including war and terrorism.
| | - |  | -----------------------------------------------------------------------------------------

These and other risks associated with our international operations may materially adversely affect our ability to attain or maintain profitable
operations.

In order to establish our sales and marketing infrastructure, we will need to grow the size of our organization, and we may experience
difficulties in managing this growth.

As of April 30, 2008, we employed 93 employees. As our development and commercialization
plans and strategies develop, we expect to need to expand the size of our employee base for managerial, operational, sales, marketing, financial and other resources. Future growth would impose significant added responsibilities on members of
management, including the need to identify, recruit, maintain, motivate and integrate additional employees. Also, our management may have to divert a disproportionate amount of its attention away from our day-to-day activities and devote a
substantial amount of time to managing these growth activities. Our future financial performance and our ability to commercialize oritavancin and our other product candidates and compete effectively will depend, in part, on our ability to
effectively manage any future growth.

If we are not successful in attracting and retaining highly qualified personnel, we may not be able to
successfully implement our business strategy.

Our ability to compete in the highly competitive biotechnology and pharmaceutical
industries depends in large part upon our ability to attract and retain highly qualified managerial, scientific and medical personnel. We are highly dependent on our management, scientific and medical personnel. In order to induce valuable employees
to remain at Targanta, we have provided options that vest over time. The value to employees of options that vest over time is significantly affected by movements in our stock price that we cannot control and may at any time be insufficient to
counteract more lucrative offers from other companies.

Our scientific team has expertise in many different aspects of drug discovery and
development. We conduct our operations at our facilities in Cambridge, Massachusetts; Indianapolis, Indiana; and Montreal, Québec. These areas are headquarters to many other biopharmaceutical companies and many academic and research
institutions and, as a result, there is currently a shortage of experienced scientists, which is likely to continue. Competition for skilled personnel in our market is very intense and competition for experienced scientists may limit our
ability to hire and retain highly qualified personnel on acceptable terms.

Despite our efforts to retain valuable employees, members of
our management, scientific and medical teams may terminate their employment with us on short notice. While we have employment agreements with certain of our employees, these employment arrangements provide for at-will employment, which means that
any of our employees could leave our employment at any time, with or without notice. The loss of the services of any of our executive officers or other key employees could potentially harm our business, operating results or financial condition. Our
success also depends on our ability to continue to attract, retain and motivate highly skilled junior, mid-level, and senior managers as well as junior, mid-level, and senior scientific and medical personnel.



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Other biotechnology and pharmaceutical companies with which we compete for qualified personnel have
greater financial and other resources, different risk profiles, and a longer history in the industry than we do. They also may provide more diverse opportunities and better chances for career advancement. Some of these characteristics may be more
appealing to high quality candidates than what we have to offer. If we are unable to continue to attract and retain high quality personnel, the rate and success at which we can discover, develop and commercialize drug candidates would be limited.

We may acquire additional businesses or form strategic alliances in the future, and we may not realize the benefits of such acquisitions.

We may acquire additional businesses or products, form strategic alliances or create joint ventures with third parties that we believe
will complement or augment our existing business. If we acquire businesses with promising markets or technologies, we may not be able to realize the benefit of acquiring such businesses if we are unable to successfully integrate them with our
existing operations and company culture. We may have difficulty in developing, manufacturing and marketing the products of a newly acquired company that enhances the performance of our combined businesses or product lines to realize value from
expected synergies. We cannot assure that, following an acquisition, we will achieve the revenues or specific net income that justifies the acquisition.

Risks Related to Legal Uncertainty

If our efforts to protect the proprietary nature of the intellectual property
related to our technologies are not adequate, we may not be able to compete effectively in our market.

We rely upon a combination of
patents, trade secret protection and confidentiality agreements to protect the intellectual property related to our technologies. Any involuntary disclosure to or misappropriation by third parties of our confidential proprietary information could
enable competitors to quickly duplicate or surpass our technological achievements, thus eroding our competitive position in our market. The strength of patents in the biotechnology and pharmaceutical field involves complex legal and scientific
questions and can be uncertain.

As of March 31, 2008, through our license agreement with Lilly, we licensed from Lilly 37 issued,
unexpired U.S. patents, three pending U.S. patent applications, approximately 439 granted, unexpired foreign patents and approximately 73 pending foreign patent applications. We also have two pending U.S. patent applications and two pending
international patent applications filed in relation to aspects of oritavancin discovered by our scientists. After the patent related to the composition of oritavancin expires on November 24, 2015, we will not be able to use this patent to block
others from marketing oritavancin in the U.S. We believe, however, that under Hatch-Waxman legislation, the composition of matter patent covering oritavancin may be eligible to be extended for up to an additional five years.

Third parties may challenge the patents we license or own. Further, the patent applications that we license or have filed may fail to result in issued
patents. Some claims in pending patent applications filed or licensed by us have been rejected by patent examiners. These claims may need to be amended and, even after amendment, a patent may not be permitted to issue. Further, the existing or
future patents to which we have rights based on our agreement with Lilly may be too narrow to prevent third parties from developing or designing around these patents. Additionally, we may lose our rights to the patents and patent applications we
license in the event of a breach or termination of the license agreement. Manufacturers of generic drugs may also seek to obtain approval to sell a generic version of oritavancin prior to the expiration of the patent on the composition of
oritavancin. If the sufficiency of the breadth or strength of protection provided by the patents we license with respect to oritavancin or the patents we pursue related to another product candidate is threatened, that could dissuade companies from
collaborating with us to develop, and threaten our ability to commercialize, oritavancin and our other product candidates. Further, if we encounter delays in our clinical trials, the period of time during which we could market our drug candidates
under patent protection would be reduced.

In addition to the protection afforded by patents, we rely on trade secret protection and
confidentiality agreements to protect proprietary know-how that is not patentable, for processes for which patents are difficult to enforce and for any other elements of our drug discovery and development processes that involve proprietary know-how,
information and technology that is not covered by patents. Although we require all of our employees, consultants, advisors and any third parties who have access to our proprietary know-how, information and technology to enter into confidentiality
agreements, we cannot be certain that this know-how, information and technology will not be disclosed or that competitors will not otherwise gain access to our trade secrets or independently develop the same or substantially equivalent information
and techniques. Further, the laws of some foreign countries do not protect proprietary rights to the same extent as the laws of the U.S. and Canada. As a result, we may encounter significant problems in protecting and defending our intellectual
property both in the U.S. and abroad. If we are unable to prevent material disclosure of the intellectual property related to our technologies to third parties, we will not be able to establish or, if established, maintain a competitive advantage in
our market, which could materially adversely affect our business, operating results and financial condition.



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Third-party claims of intellectual property infringement may prevent or delay our drug discovery, development and
commercialization efforts.

Our commercial success depends in part on our avoiding infringement of the patents and proprietary rights
of third parties. Third parties may assert that we are employing their proprietary technology without authorization. There may be third-party patents or patent applications with claims to materials, methods of manufacture or methods for treatment
related to the use or manufacture of oritavancin and/or our other product candidates. At present, we are not aware of any patent claims with merit that would adversely and materially affect our ability to develop our product candidates. We are,
however, aware of two U.S. patents, and European, Canadian and Japanese counterpart patents, with claims to naturally occurring molecules that may be produced in trace amounts as contaminants during the manufacture of oritavancin. Derivatives of
these molecules may also be present in the final oritavancin product. Based on our review of the U.S. patents and their issued claims, we do not believe that their existence would block our ability to manufacture or commercialize oritavancin in the
U.S., assuming we receive regulatory approval to market oritavancin in the U.S. Furthermore, both of these third-party U.S. patents will expire by the end of December 2008. Thus, it is likely that at least one, if not both, of the U.S. patents will
be expired by the time we obtain approval to market oritavancin in the U.S. We cannot rule out the possibility of third-party allegations related to these or any other patents. If these or any other patents were held by a court of competent
jurisdiction to cover the oritavancin manufacturing process, any molecules formed during the manufacturing process or the final oritavancin product itself, the holders of any such patents might be able to block our ability to commercialize
oritavancin unless we obtained a license under the applicable patent or patents, or until such patents expire. We cannot predict whether we would be able to obtain a license on commercially reasonable terms, if at all. Any inability to obtain such a
license under the applicable patents on commercially reasonable terms, or at all, may have a material adverse effect on our ability to commercialize oritavancin until such patents expire.

In addition, third parties may obtain patents in the future and claim that use of our product candidates or technologies infringes upon these patents.
Furthermore, parties making claims against us may obtain injunctive or other equitable relief, which could effectively block our ability to further develop and commercialize one or more of our product candidates. Defense of these claims, regardless
of their merit, would involve substantial litigation expense and would be a substantial diversion of employee resources from our business. In the event of a successful claim of infringement against us, we may have to pay substantial damages, obtain
one or more licenses from third parties or pay royalties, or we may be enjoined from further developing or commercializing our product candidates and technologies. In addition, even in the absence of litigation, we may need to obtain licenses from
third parties to advance our research or allow commercialization of our product candidates, and we have done so from time to time. We may fail to obtain future licenses at a reasonable cost or on reasonable terms, if at all. In that event, we may be
unable to further develop and commercialize one or more of our product candidates, which could harm our business significantly.

We may become involved
in lawsuits to protect or enforce our patents or the patents of our licensors, which could be expensive, time consuming and unsuccessful.

Competitors may infringe our patents or the patents of our licensors. To counter infringement or unauthorized use, we may be required to file infringement claims, which can be expensive and time-consuming. In addition, in an infringement
proceeding, a court may decide that a patent of ours or our licensors is not valid or is unenforceable, or may refuse to stop the other party from using the technology at issue on the grounds that our patents do not cover the technology in question.
An adverse result in any litigation or defense proceedings could put one or more of our patents at risk of being invalidated or interpreted narrowly and could put our patent applications at risk of not issuing.

Interference proceedings brought by the U.S. Patent and Trademark Office may be necessary to determine the priority of inventions with respect to our
patents and patent applications or those of our collaborators or licensors. An unfavorable outcome could require us to cease using the technology or to attempt to license rights to it from the prevailing party. Our business could be harmed if a
prevailing party does not offer us a license on terms that are acceptable to us. Litigation or interference proceedings may fail and, even if successful, may result in substantial costs and distraction of our management. We may not be able to
prevent, alone or with our licensors, misappropriation of our proprietary rights, particularly in countries where the laws may not protect those rights as fully as in the U.S.

Furthermore, because of the substantial amount of discovery required in connection with intellectual property litigation, there is a risk that some of
our confidential information could be compromised by disclosure during this type of litigation. In addition, there could be public announcements of the results of hearings, motions or other interim proceedings or developments. If securities analysts
or investors perceive these results to be negative, that could have a substantial adverse effect on the price of our common stock.



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Product liability lawsuits could divert our resources, result in substantial liabilities and reduce the commercial
potential of our medicines.

The risk that we may be sued on product liability claims is inherent in the development of pharmaceutical
products. These lawsuits may divert our management from pursuing our business strategy and may be costly to defend. In addition, if we are held liable in any of these lawsuits, we may incur substantial liabilities and may be forced to limit or
forgo further commercialization of those products.

Although we maintain general liability and product liability insurance, this insurance
may not fully cover potential liabilities. In addition, inability to obtain or maintain sufficient insurance coverage at an acceptable cost or to otherwise protect against potential product liability claims could prevent or inhibit the commercial
production and sale of our products, which could adversely affect our business, operating results and financial condition.

If we use hazardous and
biological materials in a manner that causes injury or violates applicable law, we may be liable for damages.

Our research and
development activities involve the controlled use of potentially hazardous substances, including chemical, biological and radioactive materials and viruses. In addition, our operations produce hazardous waste products. Federal, state and local laws
and regulations in both the U.S. and Canada govern the use, manufacture, storage, handling and disposal of hazardous materials. Although we believe that our procedures for use, handling, storing and disposing of these materials comply with legally
prescribed standards, we may incur significant additional costs to comply with applicable laws in the future. Also, even if we are in compliance with applicable laws, we cannot completely eliminate the risk of contamination or injury resulting from
hazardous materials and we may incur liability as a result of any such contamination or injury. In the event of an accident, we could be held liable for damages or penalized with fines, and the liability could exceed our resources. We only have
limited insurance for liabilities arising from hazardous materials. Compliance with applicable environmental laws and regulations is expensive, and current or future environmental regulations may impair our research, development and production
efforts, which could harm our business, operating results and financial condition.

General Company-Related Risks

Our stock price may be volatile, and the value of our stock could decline.

The trading price of our common stock is likely to be volatile. Our stock price could be subject to wide fluctuations in response to a variety of factors, including the following:



| |  |  | any adverse development or perceived adverse development with respect to the FDAs review of our NDA, including without limitation a request for additional
information;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | failure to meet or exceed revenue and financial projections we provide to the public;
| | - |  | -------------------------------------------------------------------------------------



| |  |  | actual or anticipated variations in quarterly operating results;
| | - |  | ----------------------------------------------------------------



| |  |  | failure to meet or exceed the estimates and projections of the investment community;
| | - |  | ------------------------------------------------------------------------------------



| |  |  | adverse results or delays in clinical trials;
| | - |  | ---------------------------------------------



| |  |  | changes in laws or regulations applicable to our products, including but not limited to clinical trial requirements for approvals;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



| |  |  | our decision to initiate a clinical trial, not to initiate a clinical trial or to terminate an existing clinical trial;
| | - |  | -----------------------------------------------------------------------------------------------------------------------



| |  |  | inability to obtain adequate product supply for any approved drug product or inability to do so at acceptable prices;
| | - |  | ---------------------------------------------------------------------------------------------------------------------



| |  |  | developments concerning our collaborations, including but not limited to those with our sources of manufacturing supply and our international commercialization
partners;
| | - |  | -------------------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | the termination of a collaboration or the inability to establish additional collaborations;
| | - |  | -------------------------------------------------------------------------------------------



| |  |  | adverse regulatory decisions;
| | - |  | -----------------------------



| |  |  | unanticipated serious safety concerns related to the use of oritavancin or any of our other product candidates;
| | - |  | ---------------------------------------------------------------------------------------------------------------



| |  |  | introduction of new products or services offered by us or our competitors;
| | - |  | --------------------------------------------------------------------------



| |  |  | announcements of significant acquisitions, strategic partnerships, joint ventures or capital commitments by us or our competitors;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------



| |  |  | disputes or other developments relating to proprietary rights, including patents, litigation matters and our ability to obtain patent protection for our
technologies;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------



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| |  |  | our failure to commercialize oritavancin, develop additional drug candidates and commercialize additional drug products;
| | - |  | ------------------------------------------------------------------------------------------------------------------------



| |  |  | additions or departures of key scientific or management personnel;
| | - |  | ------------------------------------------------------------------



| |  |  | issuances of debt or equity securities;
| | - |  | ---------------------------------------



| |  |  | significant lawsuits, including patent or stockholder litigation;
| | - |  | -----------------------------------------------------------------



| |  |  | changes in the market valuations of similar companies;
| | - |  | ------------------------------------------------------



| |  |  | sales of our common stock by us or our stockholders in the future;
| | - |  | ------------------------------------------------------------------



| |  |  | trading volume of our common stock; and
| | - |  | ---------------------------------------



| |  |  | other events or factors, many of which are beyond our control.
| | - |  | --------------------------------------------------------------

In addition, the stock market in general, and The Nasdaq Global Market and biotechnology companies in particular, have experienced extreme price and volume fluctuations that have often been unrelated or
disproportionate to the operating performance of these companies. Broad market and industry factors may negatively affect the market price of our common stock, regardless of our actual operating performance. In the past, following periods of
volatility in the market price of a companys securities, securities class action litigation has often been instituted against companies. This type of litigation, if instituted, could result in substantial costs and a diversion of
managements attention and resources, which would harm our business, operating results or financial condition.

We are incurring and will continue
to incur significant increased costs as a result of operating as a public company, and our management will be required to devote substantial time to new compliance initiatives.

As a public company, we will incur significant legal, accounting and other expenses that we did not incur as a private company. In addition, the
Sarbanes-Oxley Act, as well as rules subsequently implemented by the SEC and The Nasdaq Global Market, have imposed various new requirements on public companies, including requiring establishment and maintenance of effective disclosure and financial
controls and changes in corporate governance practices. Our management and other personnel will need to devote a substantial amount of time to these new compliance initiatives. Moreover, these rules and regulations will increase our legal and
financial compliance costs and will make some activities more time-consuming and costly. For example, we expect these rules and regulations to make it more difficult and more expensive for us to obtain director and officer liability insurance and we
may be required to incur substantial costs to maintain the same or similar coverage.

The Sarbanes-Oxley Act requires, among other things,
that we maintain effective internal controls for financial reporting and disclosure controls and procedures. In particular, we will be required to perform system and process evaluation and testing of our internal controls over financial reporting to
allow management and our independent registered public accounting firm to report, commencing in our Annual Report on Form 10-K for the fiscal year ending December 31, 2008, on the effectiveness of our internal controls over financial reporting,
as required by Section 404 of the Sarbanes-Oxley Act. Our testing, or the subsequent testing by our independent registered public accounting firm, may reveal deficiencies in our internal controls over financial reporting that are deemed to be
material weaknesses. Our compliance with Section 404 will require that we incur substantial accounting expense and expend significant management efforts. We currently do not have an internal audit group, and we will need to hire additional
accounting and financial staff with appropriate public company experience and technical accounting knowledge. Moreover, if we are not able to comply with the requirements of Section 404 in a timely manner or if we or our independent registered
public accounting firm identifies deficiencies in our internal controls over financial reporting that are deemed to be material weaknesses, the market price of our stock could decline and we could be subject to sanctions or investigations by Nasdaq,
the SEC or other regulatory authorities, which would require additional financial and management resources.

Sales of a substantial number of shares of
our common stock in the public market could cause our stock price to fall.

Sales of a substantial number of shares of our common stock
in the public market, or the perception that these sales might occur, could depress the market price of our common stock and could impair our ability to raise capital through the sale of additional equity securities. We are unable to predict the
effect that sales may have on the prevailing market price of our common stock.

Certain holders of shares of our common stock are entitled
to rights with respect to the registration of their shares under the Securities Act of 1933, as amended (the Securities Act). Registration of these shares under the Securities Act would result in the shares becoming freely tradable
without restriction under the Securities Act, except for shares purchased by affiliates. In addition, in March 2008, we filed a registration statement to permit the sale of shares of our common stock that we may issue under our stock option plans.
As a result, shares issued under our stock option plans may be freely sold in the public market upon issuance, subject to restrictions under the Securities Act.



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The 5.75 million shares of our common stock that were registered in connection with our initial
public offering are, except for those shares held by affiliates, freely tradable. Due to the expiration in the middle of April 2008 of the lock-up in effect with the underwriters following our initial public offering, the approximately
15.2 million remaining shares of our outstanding common stock as of April 30, 2008 are now tradable, subject to compliance with Rule 144 of the Securities Act. In addition to those outstanding shares, as of April 30, 2008, we had
outstanding warrants to purchase up to 850,287 shares of our common stock at exercise prices ranging from $8.36 to CAN $15.14 ($15.00 as of April 30, 2008) per share, and outstanding options to purchase up to 2.4 million shares of our
common stock, which options are subject to vesting conditions and have exercise prices below the market price of our common stock as of April 30, 2008.

If the number of outstanding shares of our common stock increases as a result of option exercises or the issuance of additional shares of our common stock in capital raising transactions, the market price of shares of
our common stock may be adversely affected. Further, any sales of securities by our stockholders could have a material adverse effect on the trading price of our common stock.

Future sales and issuances of our common stock or rights to purchase common stock, including pursuant to our equity incentive plans, could result in additional dilution of the percentage ownership of our
stockholders and could cause our stock price to fall.

We expect that significant additional capital will be needed in the future to
continue our planned operations. To the extent we raise additional capital by issuing equity securities, our stockholders may experience substantial dilution. We may sell common stock, convertible securities or other equity securities in one or more
transactions at prices and in a manner we determine from time to time. If we sell common stock, convertible securities or other equity securities in more than one transaction, investors may be materially diluted by subsequent sales. Such sales may
also result in material dilution to our existing stockholders, and new investors could gain rights superior to existing stockholders.

Pursuant to our 2007 Stock Option and Incentive Plan (the 2007 Plan), our management is authorized to grant stock options to our employees, directors and consultants. Our board of directors may elect to increase the number of
shares available for future grant under the 2007 Plan each year by an amount equal to up to 3.5% of all shares of our capital stock outstanding as of December 31st of each preceding year. In February 2008, our board of directors increased the
number of shares available for grant under the 2007 Plan by 733,921 shares, which equaled 3.5% of the total shares of the Companys capital stock outstanding as of December 31, 2007. As a result of this increase and the return of shares to
the 2007 Plan due to forfeitures of previously granted options under a predecessor option plan, the aggregate number of shares at March 31, 2008 available for grant under the 2007 Plan (including currently outstanding grants) is now 2,006,084.

All of the shares of common stock sold in our initial public offering will be freely tradable without restrictions or further registration
under the Securities Act, except for any shares purchased by our affiliates as defined in Rule 144 under the Securities Act. Rule 144 defines an affiliate as a person that directly, or indirectly through one or more intermediaries, controls, or is
controlled by, or is under common control with, us and would include persons such as our directors and executive officers.

Our ability to utilize our
net operating loss carryforwards and certain other tax attributes may be limited.

Under Section 382 of the Internal Revenue Code
of 1986, as amended, if a corporation undergoes an ownership change (generally defined as a greater than 50% change (by value) in its equity ownership over a three year period), the corporations ability to use its pre-change net
operating loss carryforwards and other pre-change tax attributes to offset its post-change income may be limited. We believe that, with our initial public offering, our most recent private placement and other transactions that have occurred over the
past three years, we have triggered an ownership change limitation. We may also experience ownership changes in the future as a result of subsequent shifts in our stock ownership. As a result, some of our net operating loss carryforwards
may expire before we are able to utilize them to offset taxable income.



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Some provisions of our charter documents and Delaware law may have anti-takeover effects that could discourage an
acquisition of us by others, even if an acquisition would be beneficial to our stockholders.

Provisions in our certificate of
incorporation and bylaws, as well as provisions of Delaware law, could make it more difficult for a third-party to acquire us or increase the cost of acquiring us, even if doing so would benefit our stockholders. These provisions include:



| |  |  | authorizing the issuance of blank check preferred stock, the terms of which may be established and shares of which may be issued without stockholder
approval;
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | limiting the removal of directors by the stockholders;
| | - |  | ------------------------------------------------------



| |  |  | creating a staggered board of directors;
| | - |  | ----------------------------------------



| |  |  | prohibiting stockholder action by written consent, thereby requiring all stockholder actions to be taken at a meeting of our stockholders;
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | eliminating the ability of stockholders to call a special meeting of stockholders;
| | - |  | ----------------------------------------------------------------------------------



| |  |  | permitting our board of directors to accelerate the vesting of outstanding option grants upon certain transactions that result in a change of control; and
| | - |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------



| |  |  | establishing advance notice requirements for nominations for election to the board of directors or for proposing matters that can be acted upon at stockholder
meetings.
| | - |  | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------

In addition, we are subject to Section 203 of the Delaware General Corporation Law, which generally
prohibits a Delaware corporation from engaging in any of a broad range of business combinations with an interested stockholder for a period of three years following the date on which the stockholder became an interested stockholder, unless such
transactions are approved by our board of directors. This provision could have the effect of delaying or preventing a change of control, whether or not it is desired by or beneficial to our stockholders. Further, other provisions of Delaware law may
also discourage, delay or prevent someone from acquiring us or merging with us.

Our officers and directors and other affiliates may be able to exert
significant control over the company.

Our executive officers, directors, 5% stockholders and their affiliates control more than 80% of
our outstanding common stock. Therefore, these stockholders have the ability to influence the company through this ownership position.

These stockholders may be able to determine all matters requiring stockholder approval. For example, these stockholders may be able to control elections of directors; amendments of our organizational documents; or approval of any merger,
sale of assets or other major corporation transaction. This may prevent or discourage unsolicited acquisition proposals or offers for our common stock that our stockholders may feel are in their best interest.

Our corporate compliance program cannot ensure that we are in compliance with all applicable fraud and abuse laws and regulations and other applicable
laws and regulations in the jurisdictions in which we may sell oritavancin or other product candidates, and a failure to comply with these regulations or prevail in litigation related to noncompliance could harm our business.

Our general operations, and the research, development, manufacture, sale and marketing of our products, are subject to extensive laws and regulation,
including but not limited to, health care fraud and abuse laws, such as the federal false claims act, the federal anti-kickback statute, and other state and federal laws and regulations. While we have developed and implemented a
corporate compliance program based upon what we believe are current best practices, we cannot guarantee that this program will protect us from governmental investigations or other actions or lawsuits stemming from a failure to be in compliance with
such laws or regulations. If any such actions are instituted against us and we are not successful in defending ourselves or asserting our rights, those actions could have a significant impact on our business, including the imposition of significant
fines or other sanctions.



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##### Table of Contents

|Item 2. | Unregistered Sales of Equity Securities and Use of Proceeds.
|------- | ------------------------------------------------------------

Unregistered Sales of Equity Securities

None.

Use of Proceeds

On October 9, 2007, our Registration Statement on Form S-1, as amended (File
No. 333-142842), relating to the initial public offering was declared effective by the SEC. On October 15, 2007, we closed the sale of 5,750,000 shares of common stock in the initial public offering for net proceeds to us of approximately
$51.1 million. As of March 31, 2008, $51.1 million of the net proceeds remained available and were primarily invested in highly liquid short-term investments, including money market accounts, overnight investment accounts, certificates of
deposit, commercial paper, corporate bonds, asset backed securities, United States Treasury bill and debt obligations of various government agencies, pending their use to fund our operations and expansion. There has been no material change in our
planned use of proceeds from the initial public offering from that described in the Annual Report on Form 10-K filed with the SEC on March 27, 2008.



|Item 3. | Defaults Upon Senior Securities
|------- | -------------------------------

None.



|Item 4. | Submission of Matters to a Vote of Security Holders
|------- | ---------------------------------------------------

None.



|Item 5. | Other Information
|------- | -----------------

None



|Item 6. | Exhibits
|------- | --------

The Exhibits listed in the Exhibit Index
immediately preceding the Exhibits are filed as a part of this Quarterly Report on Form 10-Q.



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SIGNATURES

Pursuant to the requirements of the Securities Exchange Act of 1934, as amended, the registrant
has duly caused this report to be signed on its behalf by the undersigned thereunto duly authorized.



|                   |  |                                   |  |                                                                                                                                                           
|------------------ |  | --------------------------------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------
|                   |  | TARGANTA THERAPEUTICS CORPORATION
|                   |  |                                  
|Date: May 13, 2008 |  | By:                               |  | /s/ Mark W. Leuchtenberger                                                                                                                                
|                   |  |                                   |  | Mark W. Leuchtenberger                                                                                                                                    
|                   |  |                                   |  | Director, President and Chief Executive Officer (principal executive officer)                                                                             
|                   |  |                                  
|Date: May 13, 2008 |  | By:                               |  | /s/ George A. Eldridge                                                                                                                                    
|                   |  |                                   |  | George A. Eldridge                                                                                                                                        
|                   |  |                                   |  | Senior Vice President, Finance and Administration, Chief Financial Officer, Treasurer and Assistant Secretary (principal accounting and financial officer)



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EXHIBIT INDEX



|            |  |                                                                                                                                                                             
|----------- |  | ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
|Exhibit No: |  | Description                                                                                                                                                                 
|            | 
|*10.1       |  | Employment Agreement, dated August 10, 2006, by and between the Registrant and Roger Miller                                                                                 
|            | 
|*10.2       |  | Employment Agreement, dated February 7, 2008, by and between the Registrant and Mona Haynes                                                                                 
|            | 
|*10.3       |  | Second Amendment to Lease, dated March 12, 2008, by and between the Registrant and American Twine Limited Partnership                                                       
|            | 
|*#10.4      |  | Amendment No. 1 to Manufacturing Services Agreement, dated March 3, 2008, by and between the Registrant and Catalent Pharma Solutions, Inc. (f/k/a Cardinal Health PTS, LLC)
|            | 
|31.1        |  | Certification of Chief Executive Officer pursuant to Rules 13a-14 or 15d-14 of the 1934 Act                                                                                 
|            | 
|31.2        |  | Certification of Chief Financial Officer pursuant to Rules 13a-14 or 15d-14 of the 1934 Act                                                                                 
|            | 
|32.1        |  | Certifications of Chief Executive Officer and Chief Financial Officer pursuant to Rules 13a-14(b) or 15d-14(b) of the 1934 Act and 18 U.S.C. Section 1350                   
|            | 
|*           |  | Incorporated by reference to the Registrants Annual Report on Form 10-K, as filed with the SEC on March 27, 2008                                                           
|            | 
|#           |  | Confidential Treatment requested for portions of this document                                                                                                              



45