# Patent

## Title
Three-dimensional structure of isoprene synthase and its use thereof for generating variants

## Abstract

The present invention provides a three-dimensional structures of P. tremuloides isoprene synthase and P. alba isoprene synthase. The invention also provides methods of using the three-dimensional structure to design isoprene synthases with improved activity for increased isoprene production in microbial host cells. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.

## Background
CROSS-REFERENCE TO RELATED APPLICATIONS
This applications claims the benefit of U.S. Provisional patent application 61/172,199, filed on Apr. 23, 2009, and U.S. Provisional patent application 61/255,831, filed on Oct. 28, 2009, the contents of both are hereby incorporated by reference in its entirety.


FIELD OF INVENTION
The present invention is related to the crystallization and three-dimensional structure determination of Populus tremuloides isoprene synthase and Populus alba isoprene synthase. The invention also provides methods of producing variants of isoprene synthase for increased isoprene production in microbial host cells.
BACKGROUND OF THE INVENTION
Isoprenoids are isoprene polymers that find use in pharmaceuticals, neutraceuticals, flavors, fragrances, and rubber products. Natural isoprenoid supplies, however, are limited due to ecological concerns. For this reason, and to provide isoprenoid compositions having fewer impurities and greater uniformity, isoprenoids such as rubber are often produced synthetically.
Isoprene (2-methyl-1,3-butadiene) is a volatile hydrocarbon that is insoluble in water and soluble in alcohol. Commercially viable quantities of isoprene can be obtained by direct isolation from petroleum C5 cracking fractions or by dehydration of C5 isoalkanes or isoalkenes (Weissermel and Arpe, Industrial Organic Chemistry, 4th ed., Wiley-VCH, pp. 117-122, 2003). The C5 skeleton can also be synthesized from smaller subunits. It would be desirable, however, to have a commercially viable method of producing isoprene that was independent of nonrenewable resources.
Biosynthetic production of isoprene occurs by two distinct metabolic pathways (Julsing et al., Appl Microbiol Biotechnol, 75:1377-1384, 2007). In eukaryotes and archae, isoprene is formed via the mevalonate (MVA) pathway, while some eubacteria and higher plants produce isoprene via the methylerythritol phosphate (MEP) pathway. Isoprene emissions from plants are light and temperature-dependent with increases linked to leaf development. An isoprene-producing enzyme, isoprene synthase, has been identified in Aspen trees (Silver and Fall, Plant Physiol, 97:1588-1591, 1991; and Silver and Fall, J Biol Chem, 270:13010-13016, 1995) and is believed to be responsible for the in vivo production of isoprene from whole leaves. Bacterial production of isoprene has also been described (Kuzma et al., Curr Microbiol, 30:97-103, 1995; and Wilkins, Chemosphere, 32:1427-1434, 1996), and varies in amount with the phase of bacterial growth and the nutrient content of the culture medium (U.S. Pat. No. 5,849,970 to Fall et al.; and Wagner et al., J Bacteriol, 181:4700-4703, 1999, both herein incorporated by reference in their entirety). The levels of isoprene obtainable through bacterial systems of the prior art, however, are insufficient for commercial uses.
Polypeptides, e.g. isoprene synthase, have a three-dimensional structure determined by the primary amino acid sequence and the environment surrounding the polypeptide. This three-dimensional structure establishes the polypeptide's activity, stability, binding affinity, binding specificity, and other biochemical attributes. Thus, knowledge of a protein's three-dimensional structure can provide much guidance in designing improvements to its biological activity, for example, greater catalytic activity, dimerization and/or solubility.
The three-dimensional structure of a polypeptide can be determined in a number of ways. Many of the most precise methods employ X-ray crystallography (See, e.g., Van Holde, (1971) Physical Biochemistry, Prentice-Hall, New Jersey, pp. 221-39). This technique relies on the ability of crystalline lattices to diffract X-rays or other forms of radiation. Diffraction experiments suitable for determining the three-dimensional structure of macromolecules typically require high-quality crystals. The crystallization properties of a polypeptide vary greatly (Dale, et al., J. Struct. Biol. 142:88-97, 2003; MacPherson, A., Methods 34:254-265, 2004; and Slabinski, L et al., Protein Science 16:2472-2482, 2007). In some cases polypeptides crystallize readily whereas in other cases polypeptides have proven extremely difficult to obtain. There is no comprehensive theory to guide efforts to crystallize macromolecules and as a result, most efforts macromolecular crystal growth is empirical in nature (MacPherson, 2004).
Previous efforts to utilize the structure of isoprene synthase in order to improve production of isoprene have relied on the structures of other terpene synthases in which three-dimensional structures are available including bornyl diphosphate synthase and 5-epi-aristolochene synthase (See e.g., U.S. patent application Ser. No. 12/429,143 and WO 2008/137092). What is needed is a three-dimensional structure of isoprene synthase to aid in the design of variants of isoprene synthase to allow commercial scale biological production of isoprenoids.
A three-dimensional structure of isoprene synthase is found to have a structurally homologous fold with previously determined synthetases, e.g. bornyl diphosphate synthase and limonene synthase, including conservation in the region involved with the coordinates of required metal ion cofactors, the active and substrate binding sites. The structure has provided insight in the conformational changes that are necessary for these enzyme to bind substrate and catalyze a coordinated series of reactions. Specifically the structure has identified flexible regions that are likely to be shared by all structurally homologous synthetase and that modification of the amino acids found in these regions and the neighboring regions would be expected to effect improved performance of these enzymes. A three-dimensional structure of isoprene synthase may provide a three-dimensional configuration of points, or reaction coordinates, representing the active site of isoprene synthase for the conversion of dimethylallyl diphosphate (DMAPP) into isoprene. Such a configuration of points can aid in the design of synthetic agents for the conversion of DMAPP into isoprene.
BRIEF SUMMARY OF THE INVENTION
The invention provides methods and compositions for generating variants of isoprene synthase with improved activity, expression or stability by utilizing three dimensional structure of isoprene synthase. In one aspect, the invention provides a) using a three dimensional structure of isoprene synthase to identify at least one location in the isoprene synthase for amino acid substitutions that is capable of increasing the activity, expression or stability of isoprene synthase; and b) modifying the isoprene synthase at the location(s) to generate an isoprene synthase variant with improved activity, expression or stability. In one embodiment, the location is selected from the group consisting of: flexible loop, disphosphate/metal binding site, active site, isoprenyl binding site, surface region, negatively charged region, hinge region, and electrostatic patch region.
In another aspect, the invention provides for methods of generating a variant of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying hydrophobic amino acid residues on the surface of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the surface amino acids of isoprene synthase; c) identifying variants with substitutions that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase amino acid sequence of SEQ ID NO:45. In some embodiments, the hydrophobic surface amino acid is selected from the group consisting of I28, V30, L130, G153, L303, L469 and L494.
In other aspects, the invention provides for an isoprene synthase variant produced any of the methods disclosed herein. In some aspects, the isoprene synthase variant is isolated.
In other aspects, the isoprene synthase variant comprises one or more substitution(s) selected from the group consisting of I28W, I28T, I28R, I28Y, V30K, L130W, L130K, L1305, L130Y, L130R, L130V, L130I, L130E, L130D, G153K, G153H, G153L, G153W, L3031, L469A, L469Q, L494P, L494C, L494I, L494V, L494S, L494G, and L494D.
In other aspects, the invention provides for isoprene synthase variant, wherein the variant comprises one or more substitution(s) of a hydrophobic surface amino acid selected from the group consisting of I28, V30, L130, G153, L303, L469 and L494. In some aspects, the mutation is selected from the group consisting of I28W, I28T, I28R, I28Y, V30K, L130W, L130K, L1305, L130Y, L130R, L130V, L130I, L130E, L130D, G153K, G153H, G153L, G153W, L3031, L469A, L469Q, L494P, L494C, L494I, L494V, L494S, L494G, and L494D.
In other aspects, the invention provides for any host cell comprising the nucleic acid encoding for any of the isoprene synthase variants disclosed herein. The invention also provides for host cells that express or are capable of expressing any of the isoprene synthase variants disclosed herein.
In other aspects, the invention provides for methods of generating a variant of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying residues in the hinge region of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the hinge region amino acids of isoprene synthase; c) identifying variants with substitutions that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase amino acid sequence of SEQ ID NO:45. In some embodiments, the hinge region amino acid is selected from the group consisting of R198, I229 and L260.
In other aspects, the invention provides for an isolated isoprene synthase variant, wherein the variant comprises one or more substitution(s) in a hinge region amino acid selected from the group consisting of R198, I229 and L260. In other aspects, the invention provides for variants comprising one or more substitution(s) selected from the group consisting of I229V, I229L, I229C, I229T, I229P, I229N, L260N, L260M, and L260I.
In other aspects, the invention provides for methods of generating a variant of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying amino acid residues in the negatively charged area of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the negatively charged area amino acids of isoprene synthase; c) identifying variants with substitutions that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase amino acid sequence of SEQ ID NO:45. In some embodiments, the negatively charged area amino acid is selected from the group consisting of D311 and D323. In some embodiments, the variant comprises one or more substitution(s) selected from the group consisting of D311M, D311F, D311L, D311G, D311I, D311A, D311T, D311R, D311V, D311E, D323M, D323W, D323Y, D323F, D323I, D323S, D323V, D323A, D323G, and D323Q.
In other aspects, the invention provides for an isoprene synthase variant, wherein the wherein the variant comprises one or more substitution(s) in a negatively charged area amino acid selected from the group consisting of D311 and D323.
In other aspects, the invention provides for methods of generating a variant of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying amino acid residues in the flexible loops of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the flexible loop amino acids of isoprene synthase; and c) identifying variants with substitutions that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase amino acid sequence of SEQ ID NO:45. In some embodiments, the flexible loop amino acid is selected from the group consisting of A443, A453, N454, H515 and A519. In other embodiments, the variant comprises one or more substitution(s) selected from the group consisting of A443S, A443G, A443R, A443Q, A453L, A453N, A453I, A453V, H515M, H515Q, A519H, A519S, A519G, A519W and A519T.
In other aspects, the invention provides for an isoprene synthase variant, wherein the variant comprises one or more substitution(s) in a flexible loop amino acid selected from the group consisting of A443, A453, N454, H515 and A519. In some embodiments, the variant is substituted at amino acid T536. In other embodiments, the variant comprises one or more substitution(s) selected from the group consisting of T536F, T536Y, T536V, T536I, T536M, T536H, T536C, T536L, T536K, T536A, T536S and T536G.
In other aspects, the invention provides for methods of generating a variant of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying amino acid residues in the diphosphate/metal binding site of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the diphosphate/metal binding site amino acids of isoprene synthase; and c) identifying variants with substitutions that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase amino acid sequence of SEQ ID NO:45.
In other aspects, the invention provides for isoprene synthase variants, wherein the variant comprises one or more substitution(s) in a diphosphate/metal binding site amino acid.
In other aspects, the invention provides for methods of generating a variant of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying amino acid residues in the isoprenyl binding site of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the isoprenyl binding site amino acids of isoprene synthase; and c) identifying variants with substitutions that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase amino acid sequence of SEQ ID NO:45).
In other aspects, the invention provides for isoprene synthase variants, wherein the variant comprises one or more substitution(s) in a isoprenyl binding site amino acid.
In other aspects, the invention provides for methods of producing isoprene, comprising: (a) providing a host cell of any one of claims 9, 15, 21, 27, 30, 34, and 38; and (b) culturing the host cell under conditions suitable for producing isoprene.
The invention provides methods of generating a variant of an isoprene synthase with improved activity, expression or stability comprising; a) identifying amino acid residues on the surface of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the surface amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the P. alba isoprene synthase comprising the amino acid sequence of SEQ ID NO: 18. In some embodiments, the amino acid substitutions include one or more of the following: hydrophobic to positively charged, positively charged to hydrophobic, hydrophobic to negatively charged, negatively charged to hydrophobic, hydrophobic to neutral polar, neutral polar to hydrophobic, neutral polar to positively charged, positively charged to neutral polar, neutral polar to negatively charged, negatively charged to neutral polar, positively charged to negatively charged, and negatively charged to positively charged.
The invention provides methods for generating a variant of an isoprene synthase with improved activity comprising a) identifying amino acid residues in or near the diphosphate/metal binding site in the three dimensional structure of P. tremuloides isoprene synthase; b) introducing one or more amino acid substitutions in or near the diphosphate/metal binding site of isoprene synthase; c) identifying mutations that improve the activity of the isoprene synthase compared to the P. tremuloides isoprene synthase comprising the amino acid sequence of SEQ ID NO:11. In some embodiments the invention provides an isolated isoprene synthase variant produced by these methods. In some embodiments, the amino acids in the diphosphate/metal binding site are selected from the group consisting of D293, Y385, S392 and D437.
The invention provides methods of generating a variant of an isoprene synthase with improved activity comprising a) identifying amino acid residues in the isoprenyl binding site in the three dimensional structure of P. tremuloides isoprene synthase; b) introducing one or more amino acid substitutions in the isoprenyl binding site of isoprene synthase; c) identifying mutations that improve the activity of the isoprene synthase compared to the P. tremuloides isoprene synthase comprising the amino acid sequence of SEQ ID NO:11. In some embodiments the invention provides an isolated isoprene synthase variant produced by this method. In some embodiments, the amino acids in the isoprenyl binding site are selected from the group consisting of S261, W264, F285, T289, S393, S394, F432 and Y512.
The invention provides methods of generating a variant of an isoprene synthase with improved activity comprising a) identifying amino acid residues in the substrate access loop in the three dimensional structure of P. tremuloides isoprene synthase; b) introducing one or more amino acid substitutions in the substrate access loop of isoprene synthase; c) identifying mutations that improve the activity of the isoprene synthase compared to the P. tremuloides isoprene synthase comprising the amino acid sequence of SEQ ID NO:11. In some embodiments the invention provides an isolated isoprene synthase variant produced by these methods. In some embodiments the amino acids in the substrate access loop are selected from the group consisting of S440, A441, S442, A443, E444, I445, A446, R447, G448, E449, T450, A451, N452, S453, Y512, H513, N514, G515, D516, A517, H518, T519, S520, P521, D522, E523, and L524.
The invention provides a variant of a parent synthase that is structurally homologous to isoprene synthase and having modified residues corresponding to or analogous to the following residues of the flexible N-terminus and/or adjacent residues; 1-28, 239, 243, 253-257, 259, 260, 293, 295-300, 303, 325, 374 of an isoprene synthase. In some embodiments, the synthase is an isoprene synthase. In some embodiments, the invention provides a variant of a parent synthase that is structurally homologous to isoprene synthase and having modified residues corresponding to or analogous to the following residues of the flexible loop I and/or adjacent residues; 438-453, 293, 295, 297, 370, 371, 373, 374, 378-380, 382, 385, 386, 433-437, 454-458, 469, 472, 476, 512 of isoprene synthase. In some embodiments, the synthase is an isoprene synthase. In some embodiments, the invention provides a variant of a parent synthase that is structurally homologous to isoprene synthase and having modified residues corresponding to or analogous to the following residues of the flexible loop II and/or adjacent residues; 512-526, 187, 188, 255, 257, 270, 271, 273, 274, 285, 288, 439, 440, 442, 508-512, and 528-532 of isoprene synthase the synthase is an isoprene synthase.
The invention provides methods of generating a variant of a parent terpene synthase or terpene synthase structural homolog with improved activity comprising a) identifying amino acid residues in or near one or more substrate access loops in the three dimensional structure of the terpene synthase or terpene synthase structural homolog, b) introducing one or more amino acid substitutions in or near the one or more substrate access loops of the terpene synthase or terpene synthase structural homolog, c) identifying substitutions that improve the activity of the terpene synthase or terpene synthase structural homolog variant compared to the parent terpene synthase or terpene synthase structural homolog. In some embodiments, the terpene synthase or terpene synthase structural homolog is an isoprene synthase. In some embodiments, the isoprene synthase is P. tremuloides isoprene synthase comprising SEQ ID NO:11. In some embodiments, the isoprene synthase is P. alba isoprene synthase comprising SEQ ID NO: 18. In some embodiments, the variant comprises a substitution of one or more of the following amino acid residues L17, L18, S19, S20, S239, R243, F253, A254, R255, D256, R257, I259, E260, D293, Y295, D296, V297, Y298, G299, T300, E303, Y325, L374, Y375, V529, L530, T534, D293, Y295, V297, E370, A371, W373, L374, S378, T379, P380, F382, Y385, F386, R433, L434 C435, N436, D437, V454, S455, C456, Y457, M458, T469, V472, I476, Y512, E187, L188, R255, R257, F270, E271, Q273, Y274, F285, V288, A439, S440, S442, S508, H509, C510, T511, Y512, R528, V529, L530, S531, and V532.
The invention provides methods of generating a variant of isoprene synthase by a) obtaining a crystal comprising an isoprene synthase; b) obtaining the atomic coordinates of the crystal; c) correlating the atomic coordinate data with one or more molecular modeling techniques; d) identifying at least one modification predicted to effect the activity, expression or stability of isoprene synthase; and e) modifying the isoprene synthase based on the prediction. In some embodiments, the isoprene synthase is P. tremuloides isoprene synthase. In some embodiments, the isoprene synthase is a P. alba isoprene synthase.
In some aspects, the invention provides methods of generating a variant of an isoprene synthase comprising a) correlating the atomic coordinate data for P. tremuloides isoprene synthesis of Table 3-7 with one of more molecular modeling techniques b) identifying at least one modification predicted to effect the activity, expression or stability of isoprene synthase; and c) modifying the isoprene synthase based on the prediction obtained in b).
In some aspects, the invention provides methods of generating a variant of an isoprene synthase comprising a) correlating the atomic coordinate data for P. alba isoprene synthesis of Table 4-2 with one of more molecular modeling techniques b) identifying at least one modification predicted to effect the activity, expression or stability of isoprene synthase; and c) modifying the isoprene synthase based on the prediction obtained in b).
In other aspects, the invention provides methods of identifying a candidate variant of an isoprene synthase comprising: a) comparing the atomic structure of the isoprene synthase without a bound ligand to the atomic structure of the isoprene synthase with a bound ligand, and b) computationally identifying candidate variants of the isoprene synthesis for the ability to bind the ligand.
The invention provides methods of generating a variant of an isoprene synthase with improved activity, expression or stability comprising; a) identifying amino acid residues on the surface of isoprene synthase based on the three dimensional structure of P. tremuloides isoprene synthase; b) introducing one or more amino acid substitutions in the surface amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the P. tremuloides isoprene synthase comprising the amino acid sequence of SEQ ID NO: 11. In some embodiments, the amino acid substitutions include one or more of the following: hydrophobic to positively charged, positively charged to hydrophobic, hydrophobic to negatively charged, negatively charged to hydrophobic, hydrophobic to neutral polar, neutral polar to hydrophobic, neutral polar to positively charged, positively charged to neutral polar, neutral polar to negatively charged, negatively charged to neutral polar, positively charged to negatively charged, and negatively charged to positively charged.
The invention provides methods of generating variants of an isoprene synthase with improved activity, expression or stability by a) identifying hydrophobic amino acid residues on the surface of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the surface amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the parent P. alba isoprene synthase.
The invention provides isolated P. alba isoprene synthase variants comprising a mutation of a hydrophobic surface amino acid at one or more of the following residues: I28, V30, L130, G153, L303, L469 and L494. In some embodiments, the variant comprises one or more of the following mutations: I28W, I28T, I28R, I28Y, V30K, L130W, L130K, L1305, L130Y, L130R, L130V, L1301, L130E, L130D, G153K, G153H, G153L, G153W, L3031, L469A, L469Q, L494P, L494C, L494I, L494V, L494S, L494G, and L494D.
The invention provides methods of generating variants of a parent isoprene synthase with improved activity, expression or stability by a) identifying residues in the hinge region of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the hinge region amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the parent P. alba isoprene synthase.
In some aspects, the invention provides isolated P. alba isoprene synthase variants comprising a mutation in or near a hinge region wherein the variant comprises a mutation at one or more of the following residues R198, I229 and L260. In some embodiments, the variant comprises one or more of the following mutations: I229V, I229L, I229C, I229T, I229P, I229N, L260N, L260M, and L260I.
The invention provides methods of generating variants of an isoprene synthase with improved activity, expression or stability by a) identifying amino acid residues in the electrostatic patch of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the electrostatic patch amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the parent P. alba isoprene synthase.
In some aspects, the invention provides isolated P. alba isoprene synthase variants, wherein the wherein the variant comprises a mutation in an electrostatic patch amino acid including, but not limited to residues D311 and D323. In some embodiments, the variant comprises one or more of the following mutations: D311M, D311F, D311L, D311G, D311I, D311A, D311T, D311R, D311V, D311E, D323M, D323W, D323Y, D323F, D323I, D323S, D323V, D323A, D323G, and D323Q.
The invention provides methods of generating variants of an isoprene synthase with improved activity, expression or stability by a) identifying amino acid residues in the flexible loops of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the flexible loop amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the parent P. alba isoprene synthase.
The invention provides isolated P. alba isoprene synthase variants comprises a mutation in a flexible loop at one or more of the following residues: A443, A453, N454, H515, A519 and E525. In some embodiments, the variant comprises one or more of the following mutations: A443S, A443G, A443R, A443Q, A453L, A453N, A453I, A453V, H515M, H515Q, A519H, A519S, A519G, A519W and A519T.
In some aspects, the invention provides isolated P. alba isoprene synthase variants mutated at amino acid T536. In some embodiments, the variant comprises one of the following mutations: T536F, T536Y, T536V, T536I, T536M, T536H, T536C, T536L, T536K, T536A, T536S and T536G.
The invention provides methods of generating variants of an isoprene synthase with improved activity, expression or stability; the method comprising; a) identifying amino acid residues in the diphosphate/metal binding site of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the diphosphate/metal binding site amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the parent P. alba isoprene synthase. In some aspects, the invention provides isolated isoprene synthase variants, comprising a mutation in a diphosphate/metal binding site residue of P. alba isoprene synthase.
The invention provides methods of generating variants of an isoprene synthase with improved activity, expression or stability; the method comprising a) identifying amino acid residues in the isoprenyl binding site of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase; b) introducing one or more amino acid substitutions in the isoprenyl binding site amino acids of isoprene synthase; c) identifying mutations that improve activity, expression or stability of the isoprene synthase compared to the parent P. alba isoprene synthase. In some aspects, the invention provides isolated P. alba isoprene synthase variants comprises a mutation in a isoprenyl binding site amino acid.
In another aspect, the invention provides a crystalline form of an isoprene synthase. In particular, the invention provides methods of improving the activity of a terpene synthase based on the crystalline form of isoprene synthase. In some embodiments, the crystalline form of the isoprene synthase further comprises a ligand, for example dimethylallyl pyrophosphate (DMAPP).
In some aspects, a crystalline form of P. tremuloides isoprene synthase comprises a structure characterized by tetragonal space group symmetry P43212 and unit cell dimensions of a=154.2 angstroms, b=154.2 angstroms and c=142.7 angstroms and wherein the alpha=beta=gamma=90 degrees. In some embodiments, the unit cell dimensions are a=146.5 to 161.9 angstroms, b=146.5 to 161.9 angstroms and c=135.6 to 149.8 angstroms and wherein the alpha=beta=gamma=90 degrees.
In some aspects, a crystalline form of P. alba isoprene synthase comprises a structure characterized by tetragonal space group symmetry P43212 and unit cell dimensions of a=156.8 angstroms, b=156.8 angstroms and c=142.5 angstroms and wherein the alpha=beta=gamma=90 degrees. In some embodiments, the unit cell dimensions are a=148.96 to 164.6 angstroms, b=148.96 to 164.6 angstroms and c=135.4 to 149.6 angstroms and wherein alpha=beta=gamma=90 degrees.
The invention provides a crystalline form of a polypeptide comprising a structure defined by one or more structure coordinates of P. tremuloides isoprene synthase amino acids Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn436, Ser261, Trp264, Phe285, Thr289, Ser393, Phe432 and Tyr512 according to Table 3-7, or similar structural coordinates for said residues comprising a root mean square deviation of less than about 1.5 Å when superimposed on the non-hydrogen atom positions of the corresponding atomic coordinates of Table 3-7. In some embodiments, the root mean square deviation is less than about 0.75 Å when superimposed on the non-hydrogen atom positions of the corresponding atomic coordinates of Table 3-7. In some embodiments, the root mean square deviation is less than about 0.35 Å when superimposed on the non-hydrogen atom positions of the corresponding atomic coordinates of Table 3-7.
In some embodiments of the invention, the invention provides a crystalline form of a P. tremuloides isoprene synthase wherein amino acid residues Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn 436 comprise the diphosphate/metal binding sites of the isoprene synthase. In some embodiments, amino acid residues Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Try 512 comprise the isoprenyl binding site of the isoprene synthase. In some embodiments, amino acid residues 438-453 having the sequence SASAEIARGETANS (SEQ ID NO:40) and residues 512-526 having the sequence YHNGDAHTSPDEL (SEQ ID NO:41) comprise the substrate access loops of the isoprene synthase. In some embodiments, amino acids 1-16 and 17-28 comprise N-terminal loops designated N-terminal loop I and N-terminal loop II.
The invention provides a crystalline form of a polypeptide that comprises an amino acid sequence having at least 75% identity to SEQ ID NO:11. In some embodiments, the polypeptide comprises an amino acid sequence having at least 85% identity to SEQ ID NO:11. In other embodiments, the polypeptide comprises an amino acid sequence having at least 90% identity to SEQ ID NO:11.
The invention provides a crystalline form of a polypeptide that comprises an amino acid sequence having at least 75% identity to SEQ ID NO:18. In some embodiments, the polypeptide comprises an amino acid sequence having at least 85% identity to SEQ ID NO:18. In other embodiments, the polypeptide comprises an amino acid sequence having at least 90% identity to SEQ ID NO:11.
The invention provides a scalable three-dimensional configuration of points, at least a portion of said points derived from structure coordinates of at least a portion of a P. tremuloides isoprene synthase molecule or molecular complex listed in Table 3-7 and having a root mean square deviation of less than about 1.5 Å from said structure coordinates. In some embodiments, at least a portion of the points derived from the P. tremuloides isoprene synthase structure coordinates are derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like diphosphate/metal binding site comprising amino acids Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn436. In some embodiments, at least a portion of the points derived from the P. tremuloides isoprene synthase structure coordinates are derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like isoprenyl binding site, the isoprenyl binding site comprising amino acids Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Tyr 512. In other embodiments, at least a portion of the points derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like flexible loop including but not limited to Loop I amino acid residues 438-453 including the sequence SASAEIARGETANS (SEQ ID NO:40), residues 512-526 having the sequence YHNGDAHTSPDEL (SEQ ID NO:41), amino acids 1-16 forming N-terminal loop I amino acids 17-28 forming N-terminal loop II. In some embodiments, at least a portion of the points derived from the P. tremuloides isoprene synthase structure coordinates are derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like diphosphate/metal binding site, the diphosphate/metal binding site comprising amino acids Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn436; and at least a portion of the points derived from the P. tremuloides isoprene synthase structure coordinates are derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like isoprenyl binding site, the isoprenyl binding site comprising amino acids Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Try 512.
The invention provides a machine-readable medium embedded with information that corresponds to a three-dimensional structural representation of a crystalline form of a P. tremuloides isoprene synthase or of a P. alba isoprene synthase. Additionally, the invention provides a computer system comprising a database containing information on the three dimensional structure of a crystalline form of a P. tremuloides isoprene synthase or a P. alba isoprene synthase and a user interface to view the information. A figure showing the high structural homology between the two coordinate sets included is shown as a stereodisgram in FIG. 64.
The invention provides agents characterized by a three-dimensional configuration of points derived from structure coordinates of at least a portion of a P. tremuloides isoprene synthase molecule or molecular complex listed in Table 3-7 and having a root mean square deviation of less than about 1.5 Å from said structure coordinates. In some embodiments, agents are characterized by a three-dimensional configuration of points derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like diphosphate/metal binding site comprising amino acids Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn436. In some embodiments, agents are characterized by at least a portion of the points derived from the P. tremuloides isoprene synthase structure coordinates are derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like isoprenyl binding site, the isoprenyl binding site comprising amino acids Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Try 512. In other embodiments, agents are characterized by at least a portion of the points derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. tremuloides isoprene synthase or P. tremuloides isoprene synthase-like flexible loop including but not limited to Loop I amino acid residues 438-453 including the sequence SASAEIARGETANS (SEQ ID NO:40), residues 512-526 having the sequence YHNGDAHTSPDEL (SEQ ID NO:41), amino acids 1-16 forming N-terminal loop I amino acids 17-28 forming N-terminal loop II.
The invention provides a scalable three-dimensional configuration of points, at least a portion of the points derived from structure coordinates of a P. alba isoprene synthase molecule or a molecular complex listed in Table 4-2 and having a root mean square deviation of less than about 1.5 Å from said structure coordinates. In some embodiments, at lease a portion of the points derived from the P. alba isoprene synthase structure coordinates are derived from structure coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. alba isoprene synthase or P. alba isoprene synthase-like sites, including but not limited to, a diphosphate/metal binding site, a isoprenyl binding site, a flexible loop, an electrostatic patch and a hinge region.
The invention provides agents characterized by a three-dimensional configuration of points derived from the structure coordinates of at lease a portion of a P. alba isoprene synthase molecule or molecular complex listed in Table 4-2 and having a root mean square deviation of less than about 1.5 Å from said structure coordinates. In some embodiments, agents are characterized by a three-dimensional configuration of points derived from the structural reaction coordinates representing the locations of at least the backbone atoms of a plurality of the amino acids defining at least one P. alba isoprene synthase or P. alba isoprene synthase-like of diphosphate/metal binding site, a flexible loop, an electrostatic patch and a hinge region.
The invention provides methods of producing isoprene by (a) providing a host cell comprising a P. alba isoprene synthase variant and (b) culturing the host cell under conditions suitable for producing isoprene.



BRIEF DESCRIPTION OF THE DRAWINGS
FIG. 1 shows the MVA and DXP metabolic pathways for isoprene (based on F. Bouvier et al., Progress in Lipid Res. 44: 357-429, 2005). The following description includes alternative names for each polypeptide in the pathways and a reference that discloses an assay for measuring the activity of the indicated polypeptide (each of these references are each hereby incorporated by reference in their entireties, particularly with respect to assays for polypeptide activity for polypeptides in the MVA and DXP pathways). Mevalonate Pathway: AACT; Acetyl-CoA acetyltransferase, MvaE, EC 2.3.1.9. Assay: J. Bacteriol., 184: 2116-2122, 2002; HMGS; Hydroxymethylglutaryl-CoA synthase, MvaS, EC 2.3.3.10. Assay: J. Bacteriol., 184: 4065-4070, 2002; HMGR; 3-Hydroxy-3-methylglutaryl-CoA reductase, MvaE, EC 1.1.1.34. Assay: J. Bacteriol., 184: 2116-2122, 2002; MVK; Mevalonate kinase, ERG12, EC 2.7.1.36. Assay: Curr Genet. 19:9-14, 1991. PMK; Phosphomevalonate kinase, ERGS, EC 2.7.4.2, Assay: Mol Cell Biol., 11:620-631, 1991; DPMDC; Diphosphomevalonate decarboxylase, MVD1, EC 4.1.1.33. Assay: Biochemistry, 33:13355-13362, 1994; IDI; Isopentenyl-diphosphate delta-isomerase, IDI1, EC 5.3.3.2. Assay: J. Biol. Chem. 264:19169-19175, 1989. DXP Pathway: DXS; 1-Deoxyxylulose-5-phosphate synthase, dxs, EC 2.2.1.7. Assay: PNAS, 94:12857-62, 1997; DXR; 1-Deoxy-D-xylulose 5-phosphate reductoisomerase, dxr, EC 2.2.1.7. Assay: Eur. J. Biochem. 269:4446-4457, 2002; MCT; 4-Diphosphocytidyl-2C-methyl-D-erythritol synthase, IspD, EC 2.7.7.60. Assay: PNAS, 97: 6451-6456, 2000; CMK; 4-Diphosphocytidyl-2-C-methyl-D-erythritol kinase, IspE, EC 2.7.1.148. Assay: PNAS, 97:1062-1067, 2000; MCS; 2C-Methyl-D-erythritol 2,4-cyclodiphosphate synthase, IspF, EC 4.6.1.12. Assay: PNAS, 96:11758-11763, 1999; HDS; 1-Hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase, ispG, EC 1.17.4.3. Assay: J. Org. Chem., 70:9168-9174, 2005; HDR; 1-Hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate reductase, IspH, EC 1.17.1.2. Assay: JACS, 126:12847-12855, 2004.
FIG. 2 provides a map of plasmid p9795.
FIG. 3 (3A, B) provides the nucleotide sequence (SEQ ID NO:1) of plasmid p9795.
FIG. 4 provides a map of plasmid pTrcKudzu.
FIG. 5 (5A, B, C) provides the nucleotide sequence (SEQ ID NO:2) of plasmid pTrcKudzu.
FIG. 6 provides a map of plasmid pMAL-C4X.
FIG. 7 (7A, B, C) provides the nucleotide sequence (SEQ ID NO:3) of plasmid pMAL-C4X.
FIG. 8 provides a map of plasmid pMAL-C4X-Kudzu.
FIG. 9 (9A, B, C, D) provide the nucleotide sequence (SEQ ID NO:4) of pMAL-C4X-Kudzu.
FIG. 10 provides maps of pET24 P. tremuloides and pET24 P. trichocarpa. 
FIG. 11 provides the amino acid Sequence (SEQ ID NO:5) of P. tremuloides IspS in P. tremuloides pET24a.
FIG. 12 (12A, B, C) provides the nucleotide sequence (SEQ ID NO:6) of plasmid P. tremuloides pET24.
FIG. 13 provides the amino acid sequence (SEQ ID NO:7) of P. trichocarpa IspS in P. trichocarpa pET24a.
FIG. 14 (14A, B, C) provides the nucleotide sequence (SEQ ID NO:8) of plasmid P. trichocarpa pET24.
FIG. 15A provides the map of plasmids pDu30.
FIG. 15B provides the map of plasmids pDu31.
FIG. 15C provides the map of plasmids pDu32.
FIG. 16 provides the amino acid sequence (SEQ ID NO:9) of the P. alba IspS variant in pDu30.
FIG. 17 (17A, B, C) provides the nucleotide sequence (SEQ ID NO:10) of plasmid pDu30.
FIG. 18 provides the amino acid sequence (SEQ ID NO:11) of the P. tremuloides IspS variant in pDu31. The numbering convention for purposes of describing the three-dimensional structure of isoprene synthase is such that the first number of the complete sequence containing the tag is −35, with the first three residues of IspS being MRR (underlined).
FIG. 19 (19A, B, C) provides the nucleotide sequence (SEQ ID NO:12) of plasmid pDu31.
FIG. 20 provides the amino acid sequence (SEQ ID NO:13) of the P. trichocarpa IspS variant in pDu32.
FIG. 21 (21A, B, C) provides the nucleotide sequence (SEQ ID NO:14) of plasmid pDu32.
FIG. 22 (22A, B, C) provides the nucleotide sequence (SEQ ID NO:15) of plasmid pDu27.
FIG. 23 provides the amino acid sequence (SEQ ID NO:16) of full length P. alba IspS in P. alba pET24a.
FIG. 24 (24A, B, C) provides the nucleotide sequence of sequence (SEQ ID NO:17) of P. alba pET24a.
FIG. 25 provides the maps of plasmids MD09-161 and MD09-163.
FIG. 26 provides amino acid sequence (SEQ ID NO:18) of P. alba MEA(+)TEV in MD09-163.
FIG. 27 (A, B, C) provides the nucleotide sequence (SEQ ID NO:19) of plasmid MD09-163. The CDS is underlined and the TEV protease site is bold.
FIG. 28 provides the amino acid sequence (SEQ ID NO:20) of P. alba FL (+) TEV in MD09-161.
FIG. 29 (29A, B, C) provides the nucleotide sequence (SEQ ID NO:21) of MD09-161. The CDS is underlined and the TEV protease site is bold.
FIG. 30 provides the three-dimensional structure of P. tremuloides IspS shown as a dimer. Chain A is in dark gray, chain B is in medium gray and the single magnesium ion found in each active site is light gray.
FIG. 31 provides a monomer view of the structure of P. tremuloides IspS. The magnesium is shown as a light gray sphere and the N- and C-terminals are indicated.
FIG. 32 shows the structural alignments between (A) BdpS and LS, (B) BdpS and P. tremuloides IspS, (C) LS and P. tremuloides IspS, and (D) TEAS and P. tremuloides IspS. In each case the first structure is in light gray and the second is in dark gray. Divalent cations are shown as spheres.
FIG. 33 shows the three dimensional structure of loops in BdpS and LS. Panel A shows the N-terminal loop of Ls in light gray and the N-terminal loop of BdpS in dark gray. Panel B shows that Loop I and Loop II are structurally homologous.
FIG. 34 shows the N-terminal loop of BdpS (dark gray) and P. tremuloides IspS (light gray) are structurally divergent. Panel A shows the N-terminal loop and panel B shows Loop I and Loop II.
FIG. 35 shows the N-terminal loop of LS (light gray) and P. tremuloides IspS (dark gray) are structurally divergent. Panel A shows the N-terminal loop and panel B shows Loop I and Loop II.
FIG. 36 shows the N-terminal loop of TEAS (light gray) and P. tremuloides IspS (dark gray) are structurally divergent. Panel A shows the N-terminal loop and panel B shows Loop I and Loop II. Loop I is disordered in TEAS.
FIG. 37 provides the amino acid sequence (SEQ ID NO:42) of a kudzu isoprene synthase.
FIG. 38 provides the amino acid sequence of a Populus [alba×tremuloides] isoprene synthase (SEQ ID NO:43).
FIG. 39 provides a map of plasmid pCL201 (pET24a P. alba IspS (MEA hairpin disrupt)).
FIG. 40 (40A, B, C) provides the nucleotide sequence (SEQ ID NO:44) of pCL201. The IspS CDS is underlined.
FIG. 41 provides the amino acid sequence of P. alba IspS residues 1 through 544 (SEQ ID NO:45).
FIG. 42 provides the three-dimensional structure of P. alba IspS shown as a dimer. Chain A is in dark gray and chain B is in light gray.
FIG. 43 provides a monomer view of the structure of P. alba IspS.
FIG. 44 provides a view of the structure of 25 sites chosen for SEL in stick diagram on the ribbon diagram backbone of the P. alba IspS monomer.
FIG. 45 shows the layout of a typical 96-well plate containing four complete libraries to be screened for isoprene production and protein concentration.
FIG. 46 provides the location of surface hydrophobic residue sites 469 and 494 of P. alba IspS.
FIG. 47 provides the location of flexible loop residue sites 443, 453 and 515 of P. alba IspS.
FIG. 48 provides the location of negatively charged residue site 323 of P. alba IspS dimer.
FIG. 49 provides the location of hinge residue site 229 of the P. alba IspS.
FIG. 50 provides the location of site 536 of P. alba IspS.
FIG. 51 shows an SDS-PAGE gel showing IspS-L494P at different stages of the purification. Lane 1—molecular weight standard; Lane 2—IspS-L494P prior to treatment with TurboTEV; Lane 3—IspS-L494P treated with TurboTEV; Lanes 4-6—IspS-L494P after final buffer exchange at different dilution levels.
FIG. 52 shows 2FO-2Fc electron density map at residue 494 contoured at 1-sigma. Panel A shows 494L, Panel B shows 494P.
FIG. 53 depicts the alignment of the loop containing residue 494. Wild type IspS is light grey and IspS-L494P is dark grey. The L494P mutation results in an alternate loop structure.
FIG. 54 depicts a SDS-PAGE gel showing purified IspS-T536F at different dilutions (lanes 2-4) and molecular weight standard (lane 1).
FIG. 55 depicts a SDS-PAGE gel showing total cell lysate (lanes 2, 5, 8), supernatant (lanes 3, 6, 9), and purified protein (lanes 4, 7, 10) for wild type IspS, IspS-L494P and IspS-T536F, respectively. A molecular weight marker is in lane 1.
FIG. 56 depicts thermal unfolding curves for wild type IspS, IspS-L494P, and IspS-T536F incubated with buffer only. TM values are indicated for each variant.
FIG. 57 depicts thermal unfolding curves for wild type IspS, IspS-L494P, and IspS-T536F incubated with 5 mM sodium pyrophosphate. TM values are indicated for each variant.
FIG. 58 depicts temperature activity ration curves for wild type IspS (WT), IspS-L494P (LP), and IspS-T536F (TF). Data are plotted as a ratio of the specific activity (nmol/mg/min) of the protein at a given temperature divided by the specific activity at 35° C.
FIG. 59 depicts local alignment of P. alba isoprene synthase and related terpene synthase enzymes (SEQ IDS NOs: 99-112).
FIG. 60 depicts a map of plasmid MD09-163 with A453N, G491S, L494P, and T536C/F mutations.
FIG. 61 depicts a gel showing a dilution series of Isoprene Synthases assayed for rate vs. [DMAPP].
FIG. 62 depicts a graph showing the specific activity of each variant with 4 mM DMAPP assayed at 30° C. The black bar indicates the specific activity of the WT isoprene synthase.
FIG. 63 depicts a graph showing rate vs. [DMAPP] for the P, SP and SPC variants of isoprene synthase and WT isoprene synthase. Each data point on the graph is the average of three independently performed kinetic assays. Error bars are reported as one standard deviation above and below the data point.
FIG. 64 depicts an alignment of the P. tremuloides (black) and P. alba structures (grey) showing high level of structural homology.



DETAILED DESCRIPTION OF THE INVENTION
The present invention provides methods and compositions comprising at least one synthase enzyme with improved activity (e.g., catalytic activity) and/or solubility, variants of synthase and agents characterized by modifications of the amino acid residues in two flexible loops and/or N-terminus and/or their adjacent regions. In particular, the present invention provides for the selective modification of these segments in a three-dimensional structure of an isoprene synthase. Isoprene synthase contemplated by the invention include, but are not limited to plant isoprene synthases; e.g., poplar isoprene synthase, kudzu isoprene synthase, oak isoprene synthase and the like. Poplar isoprene synthase include, but are not limited to, isoprene synthases from P. tremuloides, P. alba, P. alba v. tremuloides, P. trichocharpa, and the like. Variant isoprene synthases for increased isoprene production in microbial host cells are derived based on the three-dimensional structure. Agents which can increase isoprene production can also be modeled using the three-dimensional structure of an isoprene synthase provided herein. Biosynthetically produced isoprene of the present invention finds use in the manufacture of rubber and elastomers.
Unless otherwise indicated, the practice of the present invention involves conventional techniques commonly used in molecular biology, microbiology, and recombinant DNA, which are within the skill of the art. Such techniques are known to those of skill in the art and are described in numerous texts and reference works (See e.g., Sambrook et al., “Molecular Cloning: A Laboratory Manual,” Third Edition, Cold Spring Harbor, 2001; and Ausubel et al., “Current Protocols in Molecular Biology,” 1987). All patents, patent applications, articles and publications mentioned herein, both supra and infra, are hereby expressly incorporated herein by reference.
DEFINITIONS
As used herein, the term isoprene refers to 2-methyl-1,3-butadiene (CAS#78-79-5). Isoprene can be produced as the direct and final volatile C5 hydrocarbon product from the elimination of pyrophosphate from 3,3-dimethylallyl pyrophosphate (DMAPP), and does not involve the linking or polymerization of (an) IPP molecule(s) to (a) DMAPP molecule(s).
As used herein, the terms “isoprene synthase,” and “IspS,” refer to the enzymes that catalyze the elimination or pyrophosphate from diemethylallyl diphosphate (DMAPP) to form isoprene. In some preferred embodiments, the IspS is an enzyme obtained from plants such as kudzu, poplar or red oak. In some embodiments, the term “IspS” refers to a naturally occurring mature enzyme or portion thereof.
As used herein, the term “variant proteins” refers to proteins that differ from a parent protein (e.g., kudzu IspS set forth as SEQ ID NO:42 and P. alba IspS set forth in SEQ ID NO:16 or FIG. 23) and from one another by a small number of amino acid residues. The number of differing amino acid residues may be one or more, preferably 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 20, 30, 40, 50, or more amino acid residues. In some preferred embodiments, the number of different amino acids between variants is between 1 and 10. In some particularly preferred embodiments, related proteins and particularly variant proteins have at least 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, or 99% amino acid sequence identity. Related (and derivative) proteins can comprise “variant proteins.” Additionally, a related protein or a variant protein as used herein refers to a protein that differs from another related protein or a parent protein in the number of prominent regions. For example, in some embodiments, variant proteins have 1, 2, 3, 4, 5, or 10 corresponding prominent regions that differ from the parent protein.
As discussed in greater detail herein, several methods are known in the art that are suitable for generating variants of the enzymes of the present invention, including but not limited to site-saturation mutagenesis, scanning mutagenesis, insertional mutagenesis, random mutagenesis, site-directed mutagenesis, and directed-evolution, as well as various other recombinatorial approaches.
As used herein, the singular form “a”, “an”, and “the” includes plural references unless indicated otherwise.
As used herein, the term “agent” can refer to any type of composition of matter, including but not limited to, polypeptides, nucleotides, small molecules, and synthetic compounds.
As used herein, the term “gene” refers to a polynucleotide (e.g., a DNA segment) that encodes a polypeptide and includes regions preceding and following the coding regions as well as intervening sequences (introns) between individual coding segments (exons).
As used herein, the terms “starting gene” and “parent gene” refer to a gene of interest that encodes a protein of interest that is to be improved and/or changed using the present invention. Likewise, the terms “starting protein” and “parent protein” refer to a protein of interest that is to be improved and/or changed using the present invention.
As used herein, “homologous genes” refers to a pair of genes from different, but usually related species, which correspond to each other and which are identical or very similar to each other. The term encompasses genes that are separated by speciation (i.e., the development of new species) (e.g., orthologous genes), as well as genes that have been separated by genetic duplication (e.g., paralogous genes).
As used herein, “ortholog” and “orthologous genes” refer to genes in different species that have evolved from a common ancestral gene (i.e., a homologous gene) by speciation. Typically, orthologs retain the same function during the course of evolution. Identification of orthologs finds use in the reliable prediction of gene function in newly sequenced genomes.
As used herein, “paralog” and “paralogous genes” refer to genes that are related by duplication within a genome. While orthologs retain the same function through the course of evolution, paralogs evolve new functions, even though some functions are often related to the original one.
As used herein, “homology” refers to sequence similarity or identity, with identity being preferred. This homology is determined using standard techniques known in the art (See e.g., Smith and Waterman, Adv Appl Math, 2:482, 1981; Needleman and Wunsch, J Mol Biol, 48:443, 1970; Pearson and Lipman, Proc Natl Acad Sci USA, 85:2444, 1988; programs such as GAP, BESTFIT, FASTA, and TFASTA in the Wisconsin Genetics Software Package, Genetics Computer Group, Madison, Wis.; and Devereux et al., Nucl Acid Res, 12:387-395, 1984).
As used herein, an “analogous sequence” on an isoprene synthase is one wherein the function of the gene is essentially the same as the gene based on the kudzu isoprene synthase. Additionally, analogous genes include at least 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, 99% or 100% sequence identity with the sequence of the kudzu isoprene synthase. In additional embodiments more than one of the above properties applies to the sequence. Analogous sequences are determined by known methods of sequence alignment. A commonly used alignment method is BLAST, although as indicated above and below, there are other methods that also find use in aligning sequences.
“Percent sequence identity,” “percent amino acid sequence identity,” “percent gene sequence identity,” and/or “percent nucleic acid/polynucleotide sequence identity,” with respect to two amino acids, polynucleotide and/or gene sequences (as appropriate), refer to the percentage of residues that are identical in the two sequences when the sequences are optimally aligned. Thus, 80% amino acid sequence identity means that 80% of the amino acids in two optimally aligned polypeptide sequences are identical.
The phrase “substantially identical” in the context of two nucleic acids or polypeptides thus refers to a polynucleotide or polypeptide that comprising at least 70% sequence identity, preferably at least 75%, preferably at least 80%, preferably at least 85%, preferably at least 90%, preferably at least 95%, preferably at least 97%, preferably at least 98% and preferably at least 99% sequence identity as compared to a reference sequence using the programs or algorithms (e.g., BLAST, ALIGN, CLUSTAL) using standard parameters. One indication that two polypeptides are substantially identical is that the first polypeptide is immunologically cross-reactive with the second polypeptide. Typically, polypeptides that differ by conservative amino acid substitutions are immunologically cross-reactive. Thus, a polypeptide is substantially identical to a second polypeptide, for example, where the two peptides differ only by a conservative substitution. Another indication that two nucleic acid sequences are substantially identical is that the two molecules hybridize to each other under stringent conditions (e.g., within a range of medium to high stringency).
As used herein, the term “crystal lattice” means the array of points defined by the vertices of packed unit cells.
As used herein, the term “unit cell” means a basic parallelipiped shaped block. The entire volume of a crystal can be constructed by regular assembly of such blocks. Each unit cell comprises a complete representation of the unit of pattern, the repetition of which builds up the crystal. Thus, the term “unit cell” means the fundamental portion of a crystal structure that is repeated infinitely by translation in three dimensions. A unit cell is characterized by three vectors a, b, and c, not located in one plane, which form the edges of a parallelepiped. Angles α, β, and γ define the angles between the vectors: angle α is the angle between vectors b and c; angle β is the angle between vectors a and c; and angle γ is the angle between vectors a and b. The entire volume of a crystal can be constructed by regular assembly of unit cells; each unit cell comprises a complete representation of the unit of pattern, the repetition of which builds up the crystal.
The term “structure coordinates” refers to Cartesian coordinates derived from mathematical equations related to the patterns obtained on diffraction of a monochromatic beam of x-rays by the atoms (scattering centers) of an isoprene synthase complex in crystal form. The diffraction data are used to calculate an electron density map of the repeating unit of the crystal. The electron density maps are then used to establish the positions of the individual atoms of the isoprene synthase protein or protein/ligand complex.
As used herein, the terms “active site,” “binding site” or “binding pocket” refer to a region of a polypeptide or a molecular complex comprising the polypeptide that, as a result of the primary amino acid sequence of the polypeptide and/or its three-dimensional shape, favorably associates with another chemical entity or compound including ligands or inhibitors. Thus, an active site may include or consist of features such as interfaces between domains. Chemical entities or compounds that may associate with an active site include, but are not limited to, compounds, ligands, cofactors, substrates, inhibitors, agonists, antagonists, etc.
“Structural reaction residues” refers to a three-dimensional collection of atoms involved in an enzymatic reaction. For example, these would include those forming the active site, those coordinating metal ions and those forming the substrate bind region. In particular, those forming the flexible loops and N-terminus and the adjacent residues that stabilize the flexible segments when substrate is bound.
Structurally equivalent synthases refer to those synthases for which a crystallographic structure has been determined, whose atomic coordinates can be aligned by a publically available software package, such as PYMOL (DeLano Scientific LLC) such that a preponderance of the main chain alpha carbon atoms can be aligned within a rms deviation of 0.2 nm. For this purpose, a preponderance would be defined as either 50%, 60% or 70% of the total alpha carbons of the isoprene synthase structure.
The term “root mean square deviation” means the square root of the arithmetic mean of the squares of the deviations. It is a way to express the deviation or variation from a trend or object. For purposes of this invention, the “root mean square deviation” defines the variation in the backbone of a protein from the backbone of a P. tremuloides isoprene synthase, a P. alba isoprene synthase, or an active site portion thereof, as defined by the structure coordinates described herein.
“Having substantially the same three-dimensional structure” refers to a polypeptide that is characterized by a set of atomic structure coordinates that have a root mean square deviation (r.m.s.d.) of less than or equal to about 1.5 Å when superimposed onto the atomic structure coordinates of an isoprene synthase, e.g. the atomic structure coordinates of Table 3-7 or Table 4-2 when at least about 50% to 100% of the Cα atoms of the coordinates are included in the superposition.
As used herein, “homologous segment” refers to a segment of an enzyme having a root mean square deviation of less than about 1.5 Å in models of related enzymes. For example the model of the P. tremuloides isoprene synthase molecule or molecular complex listed in Table 3-7 can be used to identify homologous segments having a root mean square deviation of less than about 1.5 Å in models of related isoprene synthases.
Slight variations in structure coordinates can be generated by mathematically manipulating the isoprene synthase structure coordinates provided herein. For example, the structure coordinates set forth in Table 3-7 or Table 4-2 could be manipulated by crystallographic permutations of the structure coordinates, fractionalization of the structure coordinates, integer additions or subtractions to sets of the structure coordinates, inversion of the structure coordinates or any combination of the above. Alternatively, modifications in the crystal structure due to mutations, additions, substitutions, and/or deletions of amino acids, or other changes in any of the components that make up the crystal, could also yield variations in structure coordinates. Such slight variations in the individual coordinates will have little effect on overall shape. If such variations are within an acceptable standard error as compared to the original coordinates, the resulting three-dimensional shape is considered to be structurally equivalent. Thus, for the purpose of the structures provided herein, any active site, binding site or binding pocket defined by a set of structure coordinates for a polypeptide or for a homolog of a polypeptide from any source having a root mean square deviation of non-hydrogen atoms of less than about 1.5 Å when superimposed on the non-hydrogen atom positions of the corresponding atomic coordinates of Table 3-7 or Table 4-2, are considered substantially identical or homologous.
As used herein, “equivalent or homologous residues” refers to proteins that share particular amino acid residues. Equivalent residues may be identified by determining homology at the level of tertiary structure for a terpene synthase (e.g., isoprene synthase) whose tertiary structure has been determined by x-ray crystallography. Equivalent residues are defined as those for which the atomic coordinates of two (2) or more of the main chain atoms of a particular amino acid residue of the terpene synthase having putative equivalent residues and the substrate of interest (e.g., N on N, CA on CA, C on C and O on O) are within 0.2 nm and preferably 0.15 nm after alignment. Alignment is achieved after the best model has been oriented and positioned to give the maximum overlap of atomic coordinates of non-hydrogen protein atoms of the terpene synthases and substrates analyzed. The preferred model is the crystallographic model giving the lowest R factor for experimental diffraction data at the highest resolution available, determined using methods known to those skilled in the art of crystallography and protein characterization/analysis. For example, equivalent residues which are functionally analogous to a specific residue of isoprene synthase are defined as those amino acids at a structurally homologous synthase which may adopt a conformation such that they either alter, modify, or contribute to protein structure, substrate binding or catalysis in a manner defined or attributed to a specific residue of isoprene synthase.
Isoprene Synthase
Isoprene monomer is employed in the manufacture of polyisoprene and various copolymers (with isobutylene, butadiene, styrene, or other monomers). To build a strain (prokaryotic or eukaryotic) capable of producing commercially viable levels of isoprene requires optimization of the entire pathway, either MVA to isoprene or DXP to isoprene. A key enzyme in the pathway is isoprene synthase (IspS), which converts the precursor DMAPP to isoprene. The only isoprene synthases (IspS) identified to date are those from plants such as poplar, English oak and kudzu vine. Although some bacteria, such as Bacillus subtilis, also produce isoprene, a prokaryotic IspS has yet to be identified and the native IspS activity in Bacillus is not sufficient for a commercial process. The plant IspS enzymes identified to date have been partially characterized in part by expression in E. coli and some of the kinetic parameters of these enzymes have been determined in vitro with purified protein. However, the kinetic parameters (Km, rate, etc.) of the native IspS enzymes are insufficient for commercial production of isoprene in a biological host.
To solve this problem as described herein, an isoprene synthase is expressed in a bacterial host. In addition, the isoprene synthase is engineered for a change in a property of interest. The invention provides a three-dimensional structure which can aid in the design of variants of isoprene synthase and agents with similar three-dimensional structure and/or reaction coordinates to the three-dimensional structure provided herein. These variants and agents are useful for the commercial production of isoprene in a biological host.
Characterization of wild-type and mutant isoprene synthase is accomplished via any means or “test” suitable and is preferably based on the assessment of properties of interest. Properties of interest include but are not limited to: pH optima, temperature stability (e.g., Tm value), intracellular and extracellular solubility, Km value, kcat value, or specific activity, as well as sensitivity to potential inhibitors including substrate or product inhibition. Oxidative and proteolytic stability are also of interest. Furthermore, activation or inhibition due to metal ion effects and ionic strength is of interest. These properties and parameters can be assessed by the conversion of DMAPP to isoprene in vitro with purified or partially purified isoprene synthase or in vivo in the context of a host organism such as E. coli expressing the DXP pathway, the MVA pathway, or both. It is contemplated that enzymes having various degrees of stability, solubility, activity, and/or expression level in one or more of test conditions will find use in the present invention for the production of isoprene in a diversity of hosts.
The invention features compositions and methods for the production of increased amounts of isoprene. In particular, these compositions and methods increase the rate of isoprene production and increase the total amount of isoprene that is produced. The biosynthetic processes for isoprene production described herein are a desirable alternative to using natural rubber. As discussed further below, the amount of isoprene produced by cells can be greatly increased by introducing a heterologous nucleic acid encoding an isoprene synthase (IspS) polypeptide into the cells. Isoprene synthase polypeptides convert dimethylallyl diphosphate (DMAPP) into isoprene.
Additionally isoprene production by cells containing a heterologous isoprene synthase nucleic acid can be enhanced by increasing the amount of a 1-deoxy-D-xylulose-5-phosphate synthase (DXS) polypeptide, and/or an isopentenyl diphosphate isomerase (IDI) polypeptide, expressed by the cells. For example, a DXS nucleic acid and/or an IDI nucleic acid can be introduced into the cells. The DXS nucleic acid may be a heterologous nucleic acid or a duplicate copy of an endogenous nucleic acid. Similarly, the IDI nucleic acid may be a heterologous nucleic acid or a duplicate copy of an endogenous nucleic acid. In some embodiments, the amount of DXS and/or IDI polypeptide is increased by replacing the endogenous DXS and/or IDI promoters or regulatory regions with other promoters and/or regulatory regions that result in greater transcription of the DXS and/or IDI nucleic acids. In some embodiments, the cells contain both a heterologous nucleic acid encoding an isoprene synthase polypeptide (e.g., a plant isoprene synthase nucleic acid) and a duplicate copy of an endogenous nucleic acid encoding an isoprene synthase polypeptide.
The encoded DXS and IDI polypeptides are part of the DXP pathway for the biosynthesis of isoprene (FIG. 1). DXS polypeptides convert pyruvate and D-glyceraldehyde-3-phosphate into 1-deoxy-D-xylulose-5-phosphate. While not intending to be bound by any particular theory, it is believed that increasing the amount of DXS polypeptide increases the flow of carbon through the DXP pathway, leading to greater isoprene production. IDI polypeptides catalyze the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). While not intending to be bound by any particular theory, it is believed that increasing the amount of IDI polypeptide in cells increases the amount of IPP that is converted into DMAPP, which in turn is converted into isoprene.
In some embodiments, the production of isoprene by cells containing a heterologous isoprene synthase nucleic acid can be augmented by increasing expression of one or more MVA polypeptide(s) in the cells (FIG. 1). Exemplary MVA pathways polypeptides include any of the following polypeptides: acetyl-CoA acetyltransferase (AA-CoA thiolase) polypeptides, 3-hydroxy-3-methylglutaryl-CoA synthase (HMG-CoA synthase) polypeptides, 3-hydroxy-3-methylglutaryl-CoA reductase (HMG-CoA reductase) polypeptides, mevalonate kinase (MVK) polypeptides, phosphomevalonate kinase (PMK) polypeptides, diphosphomevalonte decarboxylase (MVD) polypeptides, IDI polypeptides, and polypeptides (e.g., fusion polypeptides) having an activity of two or more MVA pathway polypeptides. For example, one or more MVA pathway nucleic acids can be introduced into the cells. In some embodiments, the cells contain the upper MVA pathway, which includes AA-CoA thiolase, HMG-CoA synthase, and HMG-CoA reductase nucleic acids. In some embodiments, the cells contain the lower MVA pathway, which includes MVK, PMK, MVD, and IDI nucleic acids. In some embodiments, the cells contain the entire MVA pathway, which includes AA-CoA thiolase, HMG-CoA synthase, HMG-CoA reductase, MVK, PMK, MVD, and IDI nucleic acids. The MVA pathway nucleic acids may be heterologous nucleic acids or duplicate copies of endogenous nucleic acids. In some embodiments, the amount of one or more MVA pathway polypeptides is increased by replacing the endogenous promoters or regulatory regions for the MVA pathway nucleic acids with other promoters and/or regulatory regions that result in greater transcription of the MVA pathway nucleic acids. In some embodiments, the cells contain both a heterologous nucleic acid encoding an isoprene synthase polypeptide (e.g., a plant isoprene synthase nucleic acid) and a duplicate copy of an endogenous nucleic acid encoding an isoprene synthase polypeptide.
In some embodiments, at least a portion of the cells maintain the heterologous isoprene synthase, DXS, IDI, and/or MVA pathway nucleic acid for at least about 5, 10, 20, 50, 75, 100, 200, 300, or more cell divisions in a continuous culture (such as a continuous culture without dilution). In some embodiments of any of the aspects of the invention, the nucleic acid comprising the heterologous or duplicate copy of an endogenous isoprene synthase, DXS, IDI, and/or MVA pathway nucleic acid also comprises a selective marker, such as a kanamycin, ampicillin, carbenicillin, gentamicin, hygromycin, phleomycin, bleomycin, neomycin, or chloramphenicol antibiotic resistance nucleic acid.
Isoprene synthase polypeptides convert dimethylallyl diphosphate (DMAPP) into isoprene. Exemplary isoprene synthase polypeptides include polypeptides, fragments of polypeptides, peptides, and fusions polypeptides that have at least one activity of an isoprene synthase polypeptide. Standard methods can be used to determine whether a polypeptide has isoprene synthase polypeptide activity by measuring the ability of the polypeptide to convert DMAPP into isoprene in vitro, in a cell extract, or in vivo. Isoprene synthase polypeptide activity in the cell extract can be measured, for example, as described in Silver et al., J. Biol. Chem. 270:13010-13016, 1995 and references therein, which are each hereby incorporated by reference in their entireties, particularly with respect to assays for isoprene synthase polypeptide activity.
In one embodiment, DMAPP (Sigma) is evaporated to dryness under a stream of nitrogen and rehydrated to a concentration of 100 mM in 100 mM potassium phosphate buffer pH 8.2 and stored at −20° C. To perform the assay, a solution of 5 μl of 1M MgCl2, 1 mM (250 μg/ml) DMAPP, 65 μl of Plant Extract Buffer (PEB) (50 mM Tris-HCl, pH 8.0, 20 mM MgCl2, 5% glycerol, and 2 mM DTT) is added to 25 μl of cell extract in a 20 ml Headspace vial with a metal screw cap and teflon coated silicon septum (Agilent Technologies) and cultured at 37° C. for 15 minutes with shaking. The reaction is quenched by adding 200 μl of 250 mM EDTA or by heat inactivation, and isoprene is quantified by GC/MS.
Exemplary isoprene synthase nucleic acids include nucleic acids that encode a polypeptide, fragment of a polypeptide, peptide, or fusion polypeptide that has at least one activity of an isoprene synthase polypeptide. Exemplary isoprene synthase polypeptides and nucleic acids include naturally-occurring polypeptides and nucleic acids from any of the source organisms described herein as well as variant polypeptides and nucleic acids derived from any of the source organisms described herein.
In some embodiments, the isoprene synthase polypeptide or nucleic acid is from the family Fabaceae, the family Salicaceae, or the family Fagaceae. In some embodiments, the isoprene synthase polypeptide or nucleic acid is a naturally-occurring polypeptide or nucleic acid from Pueraria montana (kudzu) (Sharkey et al., Plant Physiology 137: 700-712, 2005), poplar (such as Populus alba×tremula CAC35696, Miller et al., Planta 213: 483-487, 2001) or Populus alba, aspen (such as Populus tremuloides) Silver et al., JBC 270(22): 13010-1316, 1995), or English Oak (Quercus robur) (Zimmer et al., WO 98/02550), which are each hereby incorporated by reference in their entireties, particularly with respect to isoprene synthase nucleic acids and the expression of isoprene synthase polypeptides. Suitable isoprene synthases include, but are not limited to, those identified by GenBank Accession Nos. AY341431, AY316691, AB198180, AJ294819.1, EU693027.1, EF638224.1, AM410988.1, EF147555.1, AY279379, AJ457070, and AY182241, which are each hereby incorporated by reference in their entireties, particularly with respect to sequences of isoprene synthase nucleic acids and polypeptides. In some embodiments, the isoprene synthase polypeptide or nucleic acid is not a naturally-occurring polypeptide or nucleic acid from Quercus robur (i.e., the isoprene synthase polypeptide or nucleic acid is an isoprene synthase polypeptide or nucleic acid other than a naturally-occurring polypeptide or nucleic acid from Quercus robur). In some embodiments, the isoprene synthase nucleic acid or polypeptide is not a naturally-occurring polypeptide or nucleic acid from poplar (such as Populus alba×tremula CAC35696).
Three Dimensional Structure and/or Crystallization
Polypeptides, e.g. isoprene synthase, have a three-dimensional structure determined by the primary amino acid sequence and the environment surrounding the polypeptide. This three-dimensional structure establishes the polypeptide's activity, stability, binding affinity, binding specificity, and other biochemical attributes. Thus, knowledge of a protein's three-dimensional structure can provide much guidance in designing improvements to its biological activity; for example, greater catalytic activity and/or solubility.
The three-dimensional structure of a polypeptide can be determined in a number of ways. Many of the most precise methods employ X-ray crystallography (See, e.g., Van Holde, (1971) Physical Biochemistry, Prentice-Hall, New Jersey, pp. 221-39). This technique relies on the ability of crystalline lattices to diffract X-rays or other forms of radiation. Diffraction experiments suitable for determining the three-dimensional structure of macromolecules typically require high-quality crystals. The crystallization properties of a polypeptide vary greatly (Dale, et al., J. Struct. Biol. 142:88-97, 2003; MacPherson, A., Methods 34:254-265, 2004; and Slabinski, L et al., Protein Science 16:2472-2482, 2007). In some cases, polypeptides crystallize readily whereas in other cases, polypeptides have proven extremely difficult to obtain. There is no comprehensive theory to guide efforts to crystallize macromolecules and as a result, most efforts macromolecular crystal growth is empirical in nature (MacPherson, 2004). Factors which can influence the production of crystals including physical, chemical and biochemical factors. These factors include purity of the polypeptide, pH, salt, and concentrations of other precipitants.
Another key variable in the generation of crystals of a polypeptide is the polypeptide itself. Some polypeptides crystallize rather easily while homologous proteins prove to be very difficult to crystallize (Dale et al. 2003). It is generally recognized that rigid, stable proteins are much more likely to crystallize than proteins that are internally flexible or have dynamic surfaces. Solubility is another factor that impacts macromolecular crystallization. Insoluble polypeptides do not readily form crystals because they tend to aggregate. Highly soluble polypeptides, on the other hand, do not readily form crystals because of difficulties in obtaining a supersaturated state. Glycoslyated polypeptides also do not readily form crystals because they tend to be highly soluble. As such, posttranslational modifications can have a large impact on the crystallization of a polypeptide.
Another hurdle in the development of a three-dimensional structure of a polypeptide is the “phase problem.” A crystal behaves like a three-dimensional diffraction grating, which gives rise to both constructive and destructive interference effects in the diffraction pattern, such that it appears on the detector as a series of discrete spots which are known as reflections. Each reflection contains information on all atoms in the structure and conversely each atom contributes to the intensity of each reflection. As with all forms of electro-magnetic radiation, X-rays have wave properties, in other words, they have both an amplitude and a phase. In order to recombine a diffraction pattern, both of these parameters are required for each reflection. Unfortunately, only the amplitudes can be recorded experimentally and as such, all phase information is lost. One method to solve the “phase problem” is to compare the molecular coordinates with the coordinates of a similar protein by a process called Molecular Replacement.
“Molecular Replacement” refers to the method of calculating initial phases for a new crystal of a polypeptide whose structure coordinates are unknown by orienting and positioning a polypeptide whose structure coordinates are known within the unit cell of the new crystal so as to best account for the observed diffraction pattern of the new crystal. Phases are then calculated from the oriented and positioned polypeptide and combined with observed amplitudes to provide an approximate Fourier synthesis of the structure of the polypeptides comprising the new crystal (Jones et al., 1991, Acta Crystallogr. 47:753-70; Brunger et al., 1998, Acta Crystallogr. D. Biol. Crystallogr. 54:905-21).
The isoprene synthases of plants are expected to be homologous to terpene synthases. Previous efforts to utilize the structure of isoprene synthase in order to improve production of isoprene have relied on the structures of other terpene synthases in which three-dimensional structures are available including bornyl diphosphate synthase and 5-epi-aristolochene synthase (see e.g., U.S. Provisional patent application Ser. No. 12/429,143 and WO 2008/137092).
A set of coordinates determined by X-ray crystallography is not without standard error. In general, the error in the coordinates tends to be reduced as the resolution is increased, since more experimental diffraction data is available for the model fitting and refinement. Thus, for example, more diffraction data can be collected from a crystal that diffracts to a resolution of 3.0 angstroms than from a crystal that diffracts to a lower resolution, such as 3.5 angstroms. Consequently, the refined structural coordinates will usually be more accurate when fitted and refined using data from a crystal that diffracts to higher resolution. If the coordinates are not sufficiently accurate, then the design process will be ineffective. In most cases, it is very difficult or impossible to collect sufficient diffraction data to define atomic coordinates precisely when the crystals diffract to a resolution of only 3.5 angstroms or poorer. Thus, in most cases, it is difficult to use X-ray structures in structure-based ligand design when the X-ray structures are based on crystals that diffract to a resolution of only 3.5 angstroms or poorer. However, common experience has shown that crystals diffracting to 3.0 angstroms or better can yield X-ray structures with sufficient accuracy to greatly facilitate structure-based drug design. Further improvement in the resolution can further facilitate structure-based design, but the coordinates obtained at 3.0 angstroms resolution are generally adequate for most purposes. The three-dimensional structure of isoprene synthase provided by the present invention was resolved to 3.05 angstroms (see Example 3).
Three Dimensional Structure and/or Crystallization of IspS
A number of different constructs expressing different isoprene synthases were generated in order to obtain a three-dimensional structure of the enzyme. One construct contained the kudzu isoprene synthase linked to a fragment of the maltose binding protein (MBP) to facilitate purification. The purified MBD-Kudzu isoprene synthase was subjected to commercially available crystallization screens including Crystal Screen (Hampton Research) and JCSG+ Suite (Qiagen). No fewer than 1536 different conditions were surveyed, including ranges of pH, protein concentration and crystallization reagents. In the majority of cases, the MBP-Kudzu isoprene synthase fusion protein precipitated out of solution and no crystals were obtained.
A second attempt to crystallize isoprene synthase focused on isoprene synthase from P. alba. Here the protein was linked to a histidine tag for ease of purification. Over 288 conditions were screened and the nine best crystals were prepared for data collection but the crystals either did not defract or were salt crystals. Likewise, crystals derived from a full-length, untagged P. alba isoprene synthase and an N-terminally truncated P. trichocharpa isoprene synthase did not diffract.
Crystals were obtained from a construct containing a 19 residue N-terminal truncation of P. alba isoprene synthase and linked to a histidine tag. Resolution of the crystal structure was improved from 16 Å to 5 Å. As discussed above, it is preferred that three-dimensional structures are determined in cases where crystal resolution is 3.5 Å or finer. Crystals were obtained from a second N-terminally truncated P. alba isoprene synthase following a screen of 528 variations of pH, precipitating agents, concentrations and inhibitors. In order to improve diffraction, various crystal freezing conditions were tested but the diffraction limits only improved from 10 Å to 6.5 Å. Crystallization conditions were further optimized and a crystal resolution of 2.7 Å was obtained.
An isoprene synthase from P. tremuloides was generated with an N-terminal truncation and a histidine tag and used in commercially available screens. Rod and plate-like crystals were observed and an additional 120 experiments were performed by varying pH, concentration and crystallization reagents. Here, the best crystal has a resolution of 5 Å. Modification of the freezing conditions resulted in a crystal that diffracted at 3.3 Å and ultimately to 3.05 Å using beamline 11-1 of the Stanford Synchroton Radiation Laboratory.
The phasing problem was resolved by molecular replacement using a monomer of limonene synthase as the starting model. Like isoprene synthase, limonene synthase is terpene synthase which has 41.4% sequence identity to P. tremuloides isoprene synthase.
The invention provides a crystalline form of isoprene synthase. In some aspects, the invention provides a crystalline from of P. tremuloides isoprene synthase. The crystals belong to the tetragonal space group P43212, and have unit cell dimensions a is about 154.2 Å, b is about 154.2 Å, c is about 142.7 Å where α=β=γ=90°. Unit cells dimensions may vary; for example, by 5%. In some aspects, the invention provides a crystalline from of P. alba isoprene synthase. The crystals belong to the tetragonal space group P43212, and have unit cell dimensions a is about 156.8 Å, b is about 156.8 Å, c is about 142.5 Å where α=β=γ=90°.
The structure is found to be structurally homologous to other known synthase structures specifically bornyl diphosphate synthase, 5-epi-aritolochene synthase and 4S-limonene synthase. All share a common overall tertiary fold, as measured by a lower than 2.0 Angstrom (0.2 nm) standard deviation for a preponderance of the main chain alpha carbon atoms following alignment. Isoprene synthase has 541 amino acid residues, each with one alpha carbon atom: 433 of these can be aligned with those of limonene synthase with a root mean squared deviation (rms) of 0.12 nm; 418 of these can be aligned with those of bornyl diphosphate synthase with an rms of 0.12 nm; and 395 of these can be aligned with those of 5-epi-aristolochene synthase with an rms of 0.14 nm.
The invention provides the three-dimensional structure of the active site of isoprene synthase. The metal ion and phosphate recognition region comprises amino acid residues Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn436 of the P. tremuloides isoprene synthase. As such, the invention provides the site where dimethylallyl pyrophosphate may bind and react with the isoprene synthase to produce isoprene. Side chains of amino acid residues in the P. tremuloides IspS that are found in proximity to the metal and diphosphate binding side chains include Asp 293, Tyr 385, Ser 392, and Asp 437.
The invention provides the substrate access loops of isoprene synthase. The substrate access loops of P. tremuloides IspS are in regions that deviate from the bornyl diphosphate synthase (BdpS) structure. In the BdpS structure, the residues create a cover over the active site. Upon substrate binding, the structure of P. tremuloides IspS may form a similar structure. In the P. tremuloides IspS enzyme, residues 440-453, which have the sequence SASAEIARGETANS (SEQ ID NO:40), and residues 512-526, which have the sequence YHNGDAHTSPDEL (SEQ ID NO:41), form the substrate access loops.
The invention provides the three-dimensional structure of the isoprenyl binding site of isoprene synthase. These are residues in the P. tremuloides IspS structure that may bind to the product, isoprene. These residues include Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Tyr 512.
In some aspects the invention provides the three-dimensional structure of isoprene synthase which further comprises a ligand; for example, dimethylallyl pyrophosphate. In some cases, the three-dimensional structure of isoprene synthase without a ligand is compared to the three-dimensional structure of isoprene synthase with bound ligand. Such comparisons in the three-dimensional structures of isoprene synthase with or without a ligand may reveal structural perturbations in the enzyme following substrate binding. Molecular modeling may provide clues for designing variants of isoprene synthase for improved activity.
The invention provides structurally equivalent agents that mimic the structure of isoprene synthase or a portion thereof. A structurally equivalent agent is related in terms of its three-dimensional structure. In some cases, the structurally equivalent agent mimics the activity (e.g. catalytic activity) of the isoprene synthase or a structurally equivalent portion of the isoprene synthase. For example, a structurally equivalent agent may be structurally analogous to the active site of an isoprene synthase.
Use of Three-Dimensional Structure of Isoprene Synthase
Structure information, typically in the form of the atomic structure coordinates, can be used in a variety of computational or computer-based methods to, for example, design, screen for and/or identify variants of isoprene synthase for improved activity, expression or stability. Three-dimensional modeling may be performed using the experimentally determined coordinates derived from X-ray diffraction patterns, such as those in Table 3-7 and Table 4-2, for example, wherein such modeling includes, but is not limited to, drawing pictures of the actual structures, building physical models of the actual structures, and determining the structures of related subunits and /ligand and subunit/ligand complexes using the coordinates. Such molecular modeling can utilize known X-ray diffraction molecular modeling algorithms or molecular modeling software to generate atomic coordinates corresponding to the three-dimensional structure of an isoprene synthase.
The structure coordinates generated for P. tremuloides isoprene synthase or one of its active sites shown in Table 3-7, P. alba isoprene synthase or one of its active sites shown in Table 4-2 or the structure coordinates generated by P. tremuloides or P. alba isoprene synthase/ligand complex define a unique configuration of points in space. Those of skill in the art understand that a set of structure coordinates for protein or an protein/ligand complex, or a portion thereof, define a relative set of points that, in turn, define a configuration in three dimensions. A similar or identical configuration can be defined by an entirely different set of coordinates, provided the distances and angles between coordinates remain essentially the same. In addition, a scalable configuration of points can be defined by increasing or decreasing the distances between coordinates by a scalar factor while keeping the angles essentially the same.
The invention provides methods for increasing the production of isoprene in a host cell by increasing the activity, expression or stability of an isoprene synthase in the host cell. Based on the three-dimensional structure of isoprene synthase, one of skill in the art can use computational methods to modify properties of the isoprene synthase including but not limited to pH optima, KM value, kcat value, and specific activity of the enzyme. In other aspects of the invention, the three-dimensional structure of isoprene synthase or agents with similar three-dimensional structures may be used as a guide to improve oxidative and/or proteolytic stability of isoprene synthase. The three-dimensional structure of isoprene synthase may be used to evaluate inhibitors of its enzymatic activity including, but not limited to, substrate and product inhibition. In other aspects of the invention, the three dimensional structure may be used to design isoprene synthase variants agents with similar three-dimensional structures for increased expression; for example, by making amino acid substitutions in the isoprene synthase protein which do not alter the three dimensional structure of the protein but allow more favorable expression for a given host cell.
In some aspects of the invention, a portion of the three dimensional structure of isoprene synthase may be used as a guide to design isoprene synthase variants or to design agents that mimic at least a portion of the isoprene synthase. As such, the invention provides a three dimensional configuration of points of a portion of the points shown in Table 3-7 or Table 4-2 or Table 8-2. Examples of portions of isoprene synthase include, but are not limited to, an active site, a diphosphate/metal binding site, an isoprenyl binding site, a flexible loop, a hinge region, and an electrostatic patch region.
In some aspects, the invention provides a three dimensional configuration of points that are analogous to the three dimensional configuration of points shown in Table 3-7 or Table 4-2 or Table 8-2 or a portion thereof. Analogous three dimensional configuration of points are at least 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, or 100% identical to the three dimensional configuration of points shown in Table 3-7 or Table 4-2 or a portion thereof, such as an active site, a diphosphate/metal binding site, an isoprenyl binding site, a flexible loop, a hinge region or an electrostatic patch region.
The three-dimensional structures of P. tremuloides IspS provide the identification of sites in the P. tremuloides IspS and other poplar isoprene synthases (e.g. P. alba IspS) that are candidates for mutagenesis to produce variant isoprene synthase enzymes with improved performance. The present invention provides sites isoprene synthase that might alter the interaction of the metal binding, diphosphate recognition, DMAPP chain binding, isoprenyl binding and/or the approach to the active site. Variants of isoprene synthase are designed for greater production of isoprene in host cells.
In some aspects, the invention provides methods of developing variants of isoprene synthase with improved enzyme kinetics. Improved enzyme kinetics can be determined by enzymatic assays. An increase in kcat and/or a decrease in Ki or KM compared to wild type isoprene synthase indicated an increase in the specific activity of the variant.
It is to be understood the disclosure herein for generating variants using three dimensional structure of isoprene synthase are equally applicable to other enzymes having substantially the same three-dimensional structure. This can refers to a polypeptide that is characterized by a set of atomic structure coordinates that have a root mean square deviation (r.m.s.d.) of less than or equal to about 1.5 Å when superimposed onto the atomic structure coordinates of an isoprene synthase, e.g. the atomic structure coordinates of Table 3-7 or Table 4-2 or Table 8-2 when at least about 50% to 100% of the Cα atoms of the coordinates are included in the superposition.
The invention also contemplates generating variants using homologous segments to the three dimensional structure of the isoprene synthases disclosed herein. This can refer to a segment of an enzyme having a root mean square deviation of less than about 1.5 Å in models of related enzymes. For example the model of the P. tremuloides isoprene synthase molecule or molecular complex listed in Table 3-7, Table 4-2 or Table 8-2 can be used to identify homologous segments having a root mean square deviation of less than about 1.5 Å in models of related isoprene synthases.
Slight variations in structure coordinates can be generated by mathematically manipulating the isoprene synthase structure coordinates provided herein. For example, the structure coordinates set forth in Table 3-7 or Table 4-2 or Table 8-2 could be manipulated by crystallographic permutations of the structure coordinates, fractionalization of the structure coordinates, integer additions or subtractions to sets of the structure coordinates, inversion of the structure coordinates or any combination of the above. Alternatively, modifications in the crystal structure due to mutations, additions, substitutions, and/or deletions of amino acids, or other changes in any of the components that make up the crystal, could also yield variations in structure coordinates. Such slight variations in the individual coordinates will have little effect on overall shape. If such variations are within an acceptable standard error as compared to the original coordinates, the resulting three-dimensional shape is considered to be structurally equivalent. Thus, for the purpose of the structures provided herein, any active site, binding site or binding pocket defined by a set of structure coordinates for a polypeptide or for a homolog of a polypeptide from any source having a root mean square deviation of non-hydrogen atoms of less than about 1.5 Å when superimposed on the non-hydrogen atom positions of the corresponding atomic coordinates of Table 3-7 or Table 4-2 or Table 8-2, are considered substantially identical or homologous. As such, all variants with equivalent or homologous residues are contemplated within the scope of this invention, regardless if it is has the same amino acid(s) or a different amino acid(s).
As described above, the present invention provides the three-dimensional structure of the active site (diphosphate/metal binding site) of isoprene synthase. The active site includes amino acid residues Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn436 if P. tremuloides isoprene synthase. In addition, based on the three-dimensional structure of P. tremuloides isoprene synthase, the side chains of amino acid residues found in proximity to the diphosphate/metal binding site were identified. These residues include, but are not limited to, Asp 293, Tyr 385, Ser 392, and Asp 437 of P. tremuloides isoprene synthase. Engineering of these sites may result in increased enzyme activity. In some cases, mutation in an active site residue may decrease or completely abolish the activity of the isoprene synthase.
The three-dimensional structure of isoprene synthase may also be used to identify residues that bind the substrate of isoprene synthase, e.g. DMAPP. The residues may be used as a basis to generate isoprene synthase variants that may be used modulate substrate specificity and/or reaction rates (altered on and off rates of substrate and product). These residues include, but are not limited to, Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Try 512 of P. tremuloides isoprene synthase.
The three dimensional structure of isoprene synthase has revealed that several loops forming the active site are flexible. One may exploit the flexibility to enhance enzyme performance by making substitutions in the amino aids forming these segments to facilitate the transitions the enzyme must undergo in the steps of binding substrate and allowing rearrangement of substrate in different kinetic steps that are postulated to occur during enzymatic de-phosphorylation and for electron transfer to convert DMAPP to isoprene. Three segments have been identified that form a considerable portion of the substrate binding pocket, notably the truncated N-terminus, along with two loops comprised of residues 438-453 (Loop I) and residues 512-527 (Loop II) (FIGS. 33-36). These loops may be present in at least two conformations: the “open” form in the absence of substrate and a “closed,” or active form when the substrate is bound. These residues provide targets for the generation of isoprene synthase variants with improved activity. For example, the residues in these loops of P. tremuloides isoprene synthase, including residues 440-453 (SASAEIARGETANS (SEQ ID NO:40)) and 512-524 (YHNGDAHTSPDEL (SEQ ID NO:41)), may be in a position to alter the activity of the isoprene synthase.
The flexible loop residues of isoprene synthase can be targets for Site Evaluation Library analysis. A library can be generated such that a particular amino acid residue(s) are mutated to different amino acid substitutions and then tested for activity (e.g. DMAPP activity) in an appropriate host cell. As exemplified in Example 5 below, residues A443, A453, N545, H515, A519 and E525 of the P. alba IspS (SEQ ID NO:41) were mutated and analyzed for DMAPP activity. P. alba IspS variants with improved activity identified by this analysis include, but are not limited to, A453N, H515M, A453I and A443S. Thus, other mutations in the flexible loop or mutations that affect the flexible loop can be found that increase isoprene synthase activity in the manner described herein. For example, conservative substitutions can be made that result in an increase in isoprene synthase activity.
The three-dimensional structure of isoprene synthase has revealed amino acids on the surface of the enzyme. For example, surface hydrophobic residues may affect protein folding, solubility or activity. In order to enhance the solubility of isoprene synthase, hydrophobic surface residues may be mutated to reduce the tendency of the enzyme to aggregate. In some cases, hydrophobic surface residues may be mutated to neutral of hydrophilic residues to increase the solubility and/or decrease the aggregation of isoprene synthase molecules. One skilled in the art would recognize hydrophobic residues, neutral residues and hydrophilic residues. Examples of surface hydrophobic residues include but are not limited to I28, V30, L130, G153, V299, L303, L469 and L494 of the P. alba IspS (SEQ ID NO:41). P. alba IspS variants with improved activity include, but are not limited to, L494P, L494C, L494V, L494G, L494I and L469A. Thus, other mutations in the surface hydrophobic residues can be found that increase isoprene synthase activity in the manner described herein. For example, conservative substitutions can be made that result in an increase in isoprene synthase activity. It is to be understood that all descriptions of mutations and/or substitutions herein refer to one mutation by itself or a combination (e.g., 2, 3, 4, 5, or more) of mutations. For example, an isoprene synthase variant with L494P is contemplated as well as an isoprene synthase variant with L494P and T536F.
The three dimensional structure of isoprene synthase has a “hinge region” located in a helix that spans the N-terminus and the C-terminus. In one aspect, the three dimensional structure of isoprene synthase has a “hinge region” located in a helix that spans the N-terminus and the C-terminus of the protein monomer. Without being bound by theory, the hinge region may dictate how these two halves of the enzyme may interact with each other. The hinge region includes residues 216-244. Examples of amino acid residues in the hinge region or that may interact with the hinge region include, but are not limited to, R198, I229 and L260 of the P. alba IspS (SEQ ID NO:41). Variants in the hinge region with improved activity include, but are not limited to, I229C, I229T, I229P, I229N, L260N, L260M, and L260I. Thus, other mutations in the hinge residues can be found that increase isoprene synthase activity in the manner described herein. For example, conservative substitutions can be made that result in an increase in isoprene synthase activity.
An electrostatic patch was identified by the three dimensional structure of isoprene synthase by the presence of a high density of acidic residues. Residues in the electrostatic patch include D304, E307, D311, E314 and D323. Without being bound by theory, this region may regulate activity of isoprene synthase. Examples of amino acid residues in the electrostatic patch include but are not limited to D311 and D323 of the P. alba IspS (SEQ ID NO:41). Variants with improved activity include, but are not limited to, D311M, D311F, D311L, D311G, D311I, D311A, D311T, D311R, D311V, D311E, D323W, D323Y, D323F, D323I, D323S, D323V, D323A, D323G, and D323Q. Thus, other mutations in the electrostatic patch residues or that affect the electrostatic patch can be found that increase isoprene synthase activity in the manner described herein. For example, conservative substitutions can be made that result in an increase in isoprene synthase activity.
Analysis of the three dimensional structure of isoprene synthase revealed other regions for targeting variants. For example, variants may be targeted to loop regions of the protein which can absorb structural perturbations to a greater extent than helices. As described in Example 5, residues D345, R528 and T536 of P. alba IspS (SEQ ID NO:41) were targets for SEL analysis. Without being bound by theory, D345 may be involved in dimerization of isoprene synthase. R528 adjacent to the flexible loop described above. Residue T536 is located at the C-terminal residue of the last helix on the C-terminal end of isoprene synthase. Variants with improved isoprene synthase activity include, but are not limited to, T536C, T536I, T536F, T536Y, T536A, T536K, T536L, T536R, T536V and T536M.
In some aspects of the invention, the variant isoprene synthase does not contain mutations at homologous residues corresponding to one or more of the following residues in kudzu isoprene synthase: A20, N21, Y22, Q23, P24, N25, L26, E30, F31, Q33, L35, E36, N37, L39, K40, V41, K43, L44, C57, R61, V62, D63, Q65, K87, E94, N95, L99, D100, N105, K137, E138, G143, E144, N182, L184, K185, G187, N189, T190, P225, H226, K247, T257, E258, M259, D266, R271, W278, C291, F299, V302, Y309, D310, N334, D353, S357, I358I, E361, L377, F381, E384, N389, I392, I393, K398, Y399, E401, N402, A403, S406, S407, S408, G409, A411, L413, C421, Q423, Q424, E425, D426, H430, L432, R433, S434, D437, R443, C446, F449, A456, T457, S458, A459, A460, E461, L462, E463, R464, G465, E466, T467, T468, N469, H476, N478, D479, Q485, D508, P513, A515, M523, S527, Y531, Q532, Y533, L537, G538, R539, Y542, A543, and P557 (based on FIG. 37; SEQ ID NO:42).
In other aspects of the invention, the variant isoprene synthase does not contain mutations at homologous residues corresponding to one or more of the following residues in P. alba v tremuloides isoprene synthase: K272, R274, W281, F302, V305, Y312, D313, L380, F384, E387, Y402, N404, A406, S409, S410, S411, G412, L414, Q415, L416, F449, N453, L454, A455, S456, A457, S4548, A459, E460, I461, A462, R463, G464, E465, T466, N469, C497, L521, S525, S537, E540, and residues 22 to 27 (based on FIG. 38; SEQ ID NO:43).
In other aspects of the invention, the variant isoprene synthase does not contain mutations at homologous residues corresponding to one or more of the following mutations in P. alba isoprene synthase: V10M, F125, T15A, E18G, V58I, V58F, L70Q, L70V, L70T, T71P, V79L, E89D, G94A, S119F, F120L, G127R, E175V, T212I, S257A, R262G, A266G, F280L, N297K, F305L, L319M, E323K, A328T, D342E, A359T, K366N, E368D, L374M, S396T, V4185, K438N, H440R, T442I, T442A, I449V, A469S, K500R, K505Q, G5075, 5509N, F511Y, and N532K (based on SEQ ID NO:16).
In some aspects of the invention, the variant isoprene synthase does not contain combinations of mutations at homologous residues corresponding to one or more of the following combination mutations in a single P. alba isoprene synthase: G127R/F511Y, L70Q/G94A/R262G/F305L, F12S/T15A/E18G/N297K, S396T/T442I, V10M/E323K, F120L/A266G, K438N/K500R, V79L/S509N, E175V/S257A/E368D/A469S, T71P/L374M, F280L/H440R, E89D/H440R, V58F/A328T/N532K, S119F/D342E/I449V, and K366N/G507S (based on SEQ ID NO:16).
It has been shown that mutating amino-acid residues on the surface of protease enzymes can improve their activity, expression, and stability (WO2008/153925, WO2008/153934, WO2008/153935). Surprisingly, we have found that mutating amino-acid residues on the surface of a completely different enzyme, isoprene synthase, can enhance its expression, solubility, and activity. L70R is an example of such a beneficial surface mutation.
Elucidation of the three-dimensional structure of an enzyme is essential for accurately identifying amino-acid residues on its surface. Homology modeling using structures with sequences approximately 40% identical to isoprene synthase (e.g., bornyl synthase and limonene synthase, the enzymes of known structure with closest identity to isoprene synthase) can reveal gross aspects of the modeled enzyme structure, but is insufficient to precisely identify surface-exposed residues and quantify their degree of surface exposure. Surface exposure of an amino-acid residue is quantified by the percentage of solvent-accessible surface area of its side chain.
The following classes of mutations in isoprene synthase may improve solubility of the enzyme by targeting amino-acid residues that are about >50% solvent-exposed, in some cases about >65% solvent-exposed, and in other cases >85% solvent-exposed:

    
    
        Hydrophobic→positively charged, and vice versa
        Hydrophobic→negatively charged, and vice versa
        Hydrophobic→neutral polar, and vice versa
        Neutral polar→positively charged, and vice versa
        Neutral polar→negatively charged, and vice versa
        Positively charged→negatively charged, and vice versa
    
    


These classes of mutations may also be used to improve the activity, substrate stability, dimerization of isoprene synthase.
The three-dimensional structure of isoprene synthase reveals the structural reaction coordinates of isoprene synthesis. As such, the invention provides a three-dimensional configuration of atoms involved in the catalytic conversion of DMAPP to isoprene. In some aspects, the invention provides an agent comprising a three-dimensional configuration of atoms for the catalytic conversion of DMAPP to isoprene. Example of agents include, but are not limited to, synthetic molecules including synthetic polypeptides as well as re-engineered polypeptides. For example, other members of the terpene synthase family may be altered to comprise the three-dimensional configuration of atoms for the catalytic conversion of DMAPP to isoprene.
Machine Readable Storage Media
Transformation of the structure coordinates for all or a portion of P. tremuloides isoprene synthase or an isoprene synthase/ligand complex or one of its active sites, for structurally homologous molecules, or for the structural equivalents of any of these molecules or molecular complexes as defined above, into three-dimensional graphical representations of the molecule or complex can be conveniently achieved through the use of commercially-available software.
The invention thus further provides a machine-readable storage medium including a data storage material encoded with machine readable data which, when using a machine programmed with instructions for using said data, displays a graphical three-dimensional representation of any of the molecule or molecular complexes of this invention that have been described above. In a preferred embodiment, the machine-readable data storage medium includes a data storage material encoded with machine readable data which, when using a machine programmed with instructions for using said data, displays a graphical three-dimensional representation of a molecule or molecular complex including all or any parts of a P. tremuloides isoprene synthase active site or a P. tremuloides-like active site; for example from a poplar isoprene synthase including but not limited to P. alba isoprene synthase, as defined above. In another aspect, the machine-readable data storage medium displays a graphical three-dimensional representation of a molecule or molecular complex defined by the structure coordinates of all of the amino acids in Table 3-7, ±a root mean square deviation from the backbone atoms of said amino acids of not more than 1.5 Å. In another aspect, the machine-readable data storage medium displays a graphical three-dimensional representation of a molecule or molecular complex defined by the structure coordinates of all of the amino acids in Table 4-2, ±a root mean square deviation from the backbone atoms of said amino acids of not more than 1.5 Å.
In an alternative aspect of the invention, the machine-readable data storage medium includes a data storage material encoded with a first set of machine readable data which includes the Fourier transform of the structure coordinates set forth in Table 3-7 or 4-2, and which, when using a machine programmed with instructions for using said data, can be combined with a second set of machine readable data including the x-ray diffraction pattern of a molecule or molecular complex to determine at least a portion of the structure coordinates corresponding to the second set of machine readable data.
For example, a system for reading a data storage medium may include a computer including a central processing unit (“CPU”), a working memory which may be, e.g., RAM (random access memory) or “core” memory, mass storage memory (such as one or more disk drives or CD-ROM drives), one or more display devices (e.g., cathode-ray tube (“CRT”) displays, light emitting diode (“LED”) displays, liquid crystal displays (“LCDs”), electroluminescent displays, vacuum fluorescent displays, field emission displays (“FEDs”), plasma displays, projection panels, etc.), one or more user input devices (e.g., keyboards, microphones, mice, touch screens, etc.), one or more input lines, and one or more output lines, all of which are interconnected by a conventional bidirectional system bus. The system may be a stand-alone computer, or may be networked (e.g., through local area networks, wide area networks, intranets, extranets, or the internet) to other systems (e.g., computers, hosts, servers, etc.). The system may also include additional computer controlled devices such as consumer electronics and appliances.
Input hardware may be coupled to the computer by input lines and may be implemented in a variety of ways. Machine-readable data of this invention may be inputted via the use of a modem or modems connected by a telephone line or dedicated data line. Alternatively or additionally, the input hardware may include CD-ROM drives or disk drives. In conjunction with a display terminal, a keyboard may also be used as an input device.
Output hardware may be coupled to the computer by output lines and may similarly be implemented by conventional devices. By way of example, the output hardware may include a display device for displaying a graphical representation of an active site of this invention using a program such as QUANTA. Output hardware might also include a printer, so that hard copy output may be produced, or a disk drive, to store system output for later use.
In operation, a CPU coordinates the use of the various input and output devices, coordinates data accesses from mass storage devices, accesses to and from working memory, and determines the sequence of data processing steps. A number of programs may be used to process the machine-readable data of this invention. Such programs are discussed in reference to the computational methods of drug discovery as described herein. References to components of the hardware system are included as appropriate throughout the following description of the data storage medium.
Machine-readable storage devices useful in the present invention include, but are not limited to, magnetic devices, electrical devices, optical devices, and combinations thereof. Examples of such data storage devices include, but are not limited to, hard disk devices, CD devices, digital video disk devices, floppy disk devices, removable hard disk devices, magneto-optic disk devices, magnetic tape devices, flash memory devices, bubble memory devices, holographic storage devices, and any other mass storage peripheral device. It should be understood that these storage devices include necessary hardware (e.g., drives, controllers, power supplies, etc.) as well as any necessary media (e.g., disks, flash cards, etc.) to enable the storage of data.
Isoprene Synthase Variants, Agents with Similar 3-D Structures, and their Use
Compositions and methods to make and use variants derived from the three-dimensional structure of isoprene synthase and agents with similar three-dimensional structure to isoprene synthase are provided herein.
The invention provides methods to generate and test candidate variants of isoprene synthesis based on an evaluation of the three-dimensional structure of the protein. Candidate residues for alteration are derived by a computational analysis of the three-dimensional structure with regard to one or more desired characteristics of the variant; for example, increased specific activity, increased stability, increased expression and the like. Candidate variants may then be generated using standard molecular biology techniques. Variants can be assessed based on the desired outcome. For example, a variant isoprene synthase engineered for increased specific activity can be tested for the conversion of DMAPP to isoprene in vitro with purified or partially purified variant isoprene synthase or in vivo in the context of a host organism such as E. coli. In some cases, the E. coli may also express the DXP pathway, the MVA pathway, or both. Improved activity is assessed in comparison with other isoprene synthases; for example, a wild type isoprene synthase. It is contemplated that enzymes having various degrees of stability, solubility, activity, and/or expression level in one or more of test conditions will find use in the present invention for the production of isoprene in a diversity of hosts. High throughput methods may provide an investigation of these properties in an economical manner.
The invention provides compositions and methods for the production of increased amounts of isoprene. In particular, these compositions and methods increase the rate of isoprene production and increase the total amount of isoprene that is produced. In some aspects of the invention, the amount of isoprene produced by cells may be increased by introducing a heterologous nucleic acid encoding a variant isoprene synthase polypeptide into the cells.
Exemplary Polypeptides and Nucleic Acids
Various isoprene synthase polypeptides and nucleic acids can be used in the compositions and methods of the invention. As used herein, “polypeptides” includes polypeptides, proteins, peptides, fragments of polypeptides, and fusion polypeptides that include part or all of a first polypeptide (e.g., an isoprene synthase) and part or all of a second polypeptide (e.g., a peptide that facilitates purification or detection of the fusion polypeptide, such as a His-tag). In various embodiments, a polypeptide has at least or about 50, 100, 150, 175, 200, 250, 300, 350, 400, or more amino acids. In some embodiments, the polypeptide fragment contains at least or about 25, 50, 75, 100, 150, 200, 300, or more contiguous amino acids from a full-length polypeptide and has at least or about 5%, 10%, 20%, 30%, 40%, 50%, 60%, 70%, 80%, 90%, 95%, 100% or greater than 100% of an activity of a corresponding full-length polypeptide. In particular embodiments, the polypeptide includes a segment of or the entire amino acid sequence of any naturally-occurring isoprene synthase. In some embodiments, the polypeptide has one or more mutations compared to the sequence of a wild-type (i.e., a sequence occurring in nature) isoprene synthase.
In some embodiments, the polypeptide is a heterologous polypeptide. By “heterologous polypeptide” is meant a polypeptide whose amino acid sequence is not identical to that of another polypeptide naturally expressed in the same host cell.
In various embodiments, the nucleic acid is a recombinant nucleic acid. For instance, in some embodiments, an isoprene synthase nucleic acid is operably linked to another nucleic acid encoding all or a portion of another polypeptide such that the recombinant nucleic acid encodes a fusion polypeptide that includes an isoprene synthase and all or part of another polypeptide (e.g., a peptide that facilitates purification or detection of the fusion polypeptide, such as a His-tag). In some embodiments, part or all of a recombinant nucleic acid is chemically synthesized. In some aspects, the nucleic acid is a heterologous nucleic acid. By “heterologous nucleic acid” is meant a nucleic acid whose nucleic acid sequence is not identical to that of another nucleic acid naturally found in the same host cell.
In particular embodiments the nucleic acid includes a segment of or the entire nucleic acid sequence of any naturally-occurring isoprene synthase nucleic acid. In some embodiments, the nucleic acid includes at least or about 50, 100, 150, 200, 300, 400, 500, 600, 700, 800, or more contiguous nucleotides from a naturally-occurring isoprene synthase nucleic acid. In some aspects, the nucleic acid has one or more mutations compared to the sequence of a wild-type (i.e., a sequence occurring in nature) isoprene synthase nucleic acid. In some embodiments, the nucleic acid has one or more mutations (e.g., a silent mutation) that increase the transcription or translation of isoprene synthase nucleic acid. In some embodiments, the nucleic acid is a degenerate variant of any nucleic acid encoding an isoprene synthase polypeptide.
An isoprene synthase nucleic acid can be incorporated into a vector, such as an expression vector, using standard techniques (Sambrook et al., Molecular Cloning: A Laboratory Manual, Cold Spring Harbor, 2001, which is hereby incorporated by reference in its entirety, particularly with respect to the screening of appropriate DNA sequences and the construction of vectors). Methods used to ligate the DNA construct comprising a nucleic acid of interest such as isoprene synthase, a promoter, a terminator, and other sequences and to insert them into a suitable vector are well known in the art. Additionally, vectors can be constructed using known recombination techniques (e.g., Invitrogen Life Technologies, Gateway Technology).
In some embodiments, it may be desirable to over-express isoprene synthase nucleic acids at levels far higher than currently found in naturally-occurring cells. This result may be accomplished by the selective cloning of the nucleic acids encoding those polypeptides into multicopy plasmids or placing those nucleic acids under a strong inducible or constitutive promoter. Methods for over-expressing desired polypeptides are common and well known in the art of molecular biology and examples may be found in Sambrook et al., Molecular Cloning: A Laboratory Manual, 2nd ed., Cold Spring Harbor, 2001, which is hereby incorporated by reference in its entirety, particularly with respect to cloning techniques.
The following resources include descriptions of additional general methodology useful in accordance with the invention: Kreigler, Gene Transfer and Expression; A Laboratory Manual, 1990; and Ausubel et al., Eds. Current Protocols in Molecular Biology, 1994, which are each hereby incorporated by reference in their entireties, particularly with respect to molecular biology and cloning techniques.
Exemplary Host Cells
A variety of host cells can be used to express isoprene synthase and to produce isoprene in the methods of the claimed invention. The host cell may be a cell that naturally produces isoprene or a cell that does not naturally produce isoprene. In some embodiments, the host cell naturally produces isoprene using the DXP pathway, and an isoprene synthase, DXS, and/or IDI nucleic acid is added to enhance production of isoprene using this pathway. In some embodiments, the host cell naturally produces isoprene using the MVA pathway, and an isoprene synthase and/or one or more MVA pathway nucleic acids are added to enhance production of isoprene using this pathway. In some embodiments, the host cell naturally produces isoprene using the DXP pathway and one or more MVA pathway nucleic acids are added to produce isoprene using part or all of the MVA pathway as well as the DXP pathway. In some embodiments, the host cell naturally produces isoprene using both the DXP and MVA pathways and one or more isoprene synthase, DXS, IDI, or MVA pathway nucleic acids are added to enhance production of isoprene by one or both of these pathways.
Other exemplary host cells that can be used are described in US Pub. 2009/0203102, WO 2009/076676, WO 2010/003007, WO 2009/132220, WO 2010/031062, WO 2010/031068, WO 2010/031076, WO 2010/031077, and WO 2010/031079.
Exemplary Transformation Methods
Isoprene synthase, DXS, IDI, and/or MVA pathway nucleic acids or vectors containing them can be inserted into a host cell (e.g., a bacterial cell) using standard techniques for expression of the encoded isoprene synthase, DXS, IDI, and/or MVA pathway polypeptide. Introduction of a DNA construct or vector into a host cell can be performed using techniques such as transformation, electroporation, nuclear microinjection, transduction, transfection (e.g., lipofection mediated or DEAE-Dextrin mediated transfection or transfection using a recombinant phage virus), incubation with calcium phosphate DNA precipitate, high velocity bombardment with DNA-coated microprojectiles, and protoplast fusion. General transformation techniques are known in the art (see, e.g., Current Protocols in Molecular Biology (F. M. Ausubel et al. (eds) Chapter 9, 1987; Sambrook et al., Molecular Cloning: A Laboratory Manual, 3rd ed., Cold Spring Harbor, 2001; and Campbell et al., Curr Genet, 16:53-56, 1989, which are each hereby incorporated by reference in their entireties, particularly with respect to transformation methods). The introduced nucleic acids may be integrated into chromosomal DNA or maintained as extrachromosomal replicating sequences.
Other exemplary transformation methods that can be used are described in US Pub. 2009/0203102, WO 2009/076676, WO 2010/003007, WO 2009/132220, WO 2010/031062, WO 2010/031068, WO 2010/031076, WO 2010/031077, and WO 2010/031079.
Exemplary Cell Culture Media
Any carbon source can be used to cultivate the host cells. The term “carbon source” refers to one or more carbon-containing compounds capable of being metabolized by a host cell or organism. For example, the cell medium used to cultivate the host cells may include any carbon source suitable for maintaining the viability or growing the host cells.
In some embodiments, the carbon source is a carbohydrate (such as monosaccharide, disaccharide, oligosaccharide, or polysaccharides), invert sugar (e.g., enzymatically treated sucrose syrup), glycerol, glycerine (e.g., a glycerine byproduct of a biodiesel or soap-making process), dihydroxyacetone, one-carbon source, fatty acid (e.g., a saturated fatty acid, unsaturated fatty acid, or polyunsaturated fatty acid), lipid, phospholipid, glycerolipid, monoglyceride, diglyceride, triglyceride, polypeptide (e.g., a microbial or plant protein or peptide), renewable carbon source (e.g., a biomass carbon source such as a hydrolyzed biomass carbon source; beet sugar or cane sugar molasses), yeast extract, component from a yeast extract, polymer, acid, alcohol, aldehyde, ketone, amino acid, succinate, lactate, acetate, ethanol, or any combination of two or more of the foregoing. In some embodiments, the carbon source is a product of photosynthesis, including, but not limited to, glucose.
Exemplary monosaccharides include glucose and fructose; exemplary oligosaccharides include lactose and sucrose, and exemplary polysaccharides include starch and cellulose. Exemplary carbohydrates include C6 sugars (e.g., fructose, mannose, galactose, or glucose) and C5 sugars (e.g., xylose or arabinose). In some embodiments, the cell medium includes a carbohydrate as well as a carbon source other than a carbohydrate (e.g., glycerol, glycerine, dihydroxyacetone, one-carbon source, fatty acid, lipid, phospholipid, glycerolipid, monoglyceride, diglyceride, triglyceride, renewable carbon source, or a component from a yeast extract). In some embodiments, the cell medium includes a carbohydrate as well as a polypeptide (e.g., a microbial or plant protein or peptide). In some embodiments, the microbial polypeptide is a polypeptide from yeast or bacteria. In some embodiments, the plant polypeptide is a polypeptide from soy, corn, canola, jatropha, palm, peanut, sunflower, coconut, mustard, rapeseed, cottonseed, palm kernel, olive, safflower, sesame, or linseed.
In some embodiments, the concentration of the carbohydrate is at least or about 5 grams per liter of broth (g/L, wherein the volume of broth includes both the volume of the cell medium and the volume of the cells), such as at least or about 10, 15, 20, 30, 40, 50, 60, 80, 100, 150, 200, 300, 400, or more g/L. In some embodiments, the concentration of the carbohydrate is between about 50 and about 400 g/L, such as between about 100 and about 360 g/L, between about 120 and about 360 g/L, or between about 200 and about 300 g/L. In some embodiments, this concentration of carbohydrate includes the total amount of carbohydrate that is added before and/or during the culturing of the host cells.
Exemplary lipids are any substance containing one or more fatty acids that are C4 and above fatty acids that are saturated, unsaturated, or branched.
Exemplary fatty acids include compounds of the formula R—COOH, where “R” is a hydrocarbon. Exemplary unsaturated fatty acids include compounds where “R” includes at least one carbon-carbon double bond. Exemplary unsaturated fatty acids include, but are not limited to, oleic acid, vaccenic acid, linoleic acid, palmitelaidic acid, and arachidonic acid. Exemplary polyunsaturated fatty acids include compounds where “R” includes a plurality of carbon-carbon double bonds. Exemplary saturated fatty acids include compounds where “R” is a saturated aliphatic group. In some embodiments, the carbon source includes one or more C12-C22 fatty acids, such as a C12 saturated fatty acid, a C14 saturated fatty acid, a C16 saturated fatty acid, a C18 saturated fatty acid, a C20 saturated fatty acid, or a C22 saturated fatty acid. In an exemplary embodiment, the fatty acid is palmitic acid. In some embodiments, the carbon source is a salt of a fatty acid (e.g., an unsaturated fatty acid), a derivative of a fatty acid (e.g., an unsaturated fatty acid), or a salt of a derivative of fatty acid (e.g., an unsaturated fatty acid). Suitable salts include, but are not limited to, lithium salts, potassium salts, sodium salts, and the like. Di- and triglycerols are fatty acid esters of glycerol.
In some embodiments, the concentration of the lipid, fatty acid, monoglyceride, diglyceride, or triglyceride is at least or about 1 gram per liter of broth (g/L, wherein the volume of broth includes both the volume of the cell medium and the volume of the cells), such as at least or about 5, 10, 15, 20, 30, 40, 50, 60, 80, 100, 150, 200, 300, 400, or more g/L. In some embodiments, the concentration of the lipid, fatty acid, monoglyceride, diglyceride, or triglyceride is between about 10 and about 400 g/L, such as between about 25 and about 300 g/L, between about 60 and about 180 g/L, or between about 75 and about 150 g/L. In some embodiments, the concentration includes the total amount of the lipid, fatty acid, monoglyceride, diglyceride, or triglyceride that is added before and/or during the culturing of the host cells. In some embodiments, the carbon source includes both (i) a lipid, fatty acid, monoglyceride, diglyceride, or triglyceride and (ii) a carbohydrate, such as glucose. In some embodiments, the ratio of the lipid, fatty acid, monoglyceride, diglyceride, or triglyceride to the carbohydrate is about 1:1 on a carbon basis (i.e., one carbon in the lipid, fatty acid, monoglyceride, diglyceride, or triglyceride per carbohydrate carbon). In particular embodiments, the amount of the lipid, fatty acid, monoglyceride, diglyceride, or triglyceride is between about 60 and 180 g/L, and the amount of the carbohydrate is between about 120 and 360 g/L.
Exemplary microbial polypeptide carbon sources include one or more polypeptides from yeast or bacteria. Exemplary plant polypeptide carbon sources include one or more polypeptides from soy, corn, canola, jatropha, palm, peanut, sunflower, coconut, mustard, rapeseed, cottonseed, palm kernel, olive, safflower, sesame, or linseed.
Exemplary renewable carbon sources include cheese whey permeate, cornsteep liquor, sugar beet molasses, barley malt, and components from any of the foregoing. Exemplary renewable carbon sources also include glucose, hexose, pentose and xylose present in biomass, such as corn, switchgrass, sugar cane, cell waste of fermentation processes, and protein by-product from the milling of soy, corn, or wheat. In some embodiments, the biomass carbon source is a lignocellulosic, hemicellulosic, or cellulosic material such as, but are not limited to, a grass, wheat, wheat straw, bagasse, sugar cane bagasse, soft wood pulp, corn, corn cob or husk, corn kernel, fiber from corn kernels, corn stover, switch grass, rice hull product, or a by-product from wet or dry milling of grains (e.g., corn, sorghum, rye, triticate, barley, wheat, and/or distillers grains). Exemplary cellulosic materials include wood, paper and pulp waste, herbaceous plants, and fruit pulp. In some embodiments, the carbon source includes any plant part, such as stems, grains, roots, or tubers. In some embodiments, all or part of any of the following plants are used as a carbon source: corn, wheat, rye, sorghum, triticate, rice, millet, barley, cassaya, legumes, such as beans and peas, potatoes, sweet potatoes, bananas, sugarcane, and/or tapioca. In some embodiments, the carbon source is a biomass hydrolysate, such as a biomass hydrolysate that includes both xylose and glucose or that includes both sucrose and glucose.
In some embodiments, the renewable carbon source (such as biomass) is pretreated before it is added to the cell culture medium. In some embodiments, the pretreatment includes enzymatic pretreatment, chemical pretreatment, or a combination of both enzymatic and chemical pretreatment (see, for example, Farzaneh et al., Bioresource Technology 96 (18): 2014-2018, 2005; U.S. Pat. No. 6,176,176; U.S. Pat. No. 6,106,888; which are each hereby incorporated by reference in their entireties, particularly with respect to the pretreatment of renewable carbon sources). In some embodiments, the renewable carbon source is partially or completely hydrolyzed before it is added to the cell culture medium.
In some embodiments, the renewable carbon source (such as corn stover) undergoes ammonia fiber expansion (AFEX) pretreatment before it is added to the cell culture medium (see, for example, Farzaneh et al., Bioresource Technology 96 (18): 2014-2018, 2005). During AFEX pretreatment, a renewable carbon source is treated with liquid anhydrous ammonia at moderate temperatures (such as about 60 to about 100° C.) and high pressure (such as about 250 to about 300 psi) for about 5 minutes. Then, the pressure is rapidly released. In this process, the combined chemical and physical effects of lignin solubilization, hemicellulose hydrolysis, cellulose decrystallization, and increased surface area enables near complete enzymatic conversion of cellulose and hemicellulose to fermentable sugars. AFEX pretreatment has the advantage that nearly all of the ammonia can be recovered and reused, while the remaining serves as nitrogen source for microbes in downstream processes. Also, a wash stream is not required for AFEX pretreatment. Thus, dry matter recovery following the AFEX treatment is essentially 100%. AFEX is basically a dry-to-dry process. The treated renewable carbon source is stable for long periods and can be fed at very high solid loadings in enzymatic hydrolysis or fermentation processes. Cellulose and hemicellulose are well preserved in the AFEX process, with little or no degradation. There is no need for neutralization prior to the enzymatic hydrolysis of a renewable carbon source that has undergone AFEX pretreatment. Enzymatic hydrolysis of AFEX-treated carbon sources produces clean sugar streams for subsequent fermentation use.
In some embodiments, the concentration of the carbon source (e.g., a renewable carbon source) is equivalent to at least or about 0.1, 0.5, 1, 1.5 2, 3, 4, 5, 10, 15, 20, 30, 40, or 50% glucose (w/v). The equivalent amount of glucose can be determined by using standard HPLC methods with glucose as a reference to measure the amount of glucose generated from the carbon source. In some embodiments, the concentration of the carbon source (e.g., a renewable carbon source) is equivalent to between about 0.1 and about 20% glucose, such as between about 0.1 and about 10% glucose, between about 0.5 and about 10% glucose, between about 1 and about 10% glucose, between about 1 and about 5% glucose, or between about 1 and about 2% glucose.
In some embodiments, the carbon source includes yeast extract or one or more components of yeast extract. In some embodiments, the concentration of yeast extract is at least 1 gram of yeast extract per liter of broth (g/L, wherein the volume of broth includes both the volume of the cell medium and the volume of the cells), such at least or about 5, 10, 15, 20, 30, 40, 50, 60, 80, 100, 150, 200, 300, or more g/L. In some embodiments, the concentration of yeast extract is between about 1 and about 300 g/L, such as between about 1 and about 200 g/L, between about 5 and about 200 g/L, between about 5 and about 100 g/L, or between about 5 and about 60 g/L. In some embodiments, the concentration includes the total amount of yeast extract that is added before and/or during the culturing of the host cells. In some embodiments, the carbon source includes both yeast extract (or one or more components thereof) and another carbon source, such as glucose. In some embodiments, the ratio of yeast extract to the other carbon source is about 1:5, about 1:10, or about 1:20 (w/w).
Additionally the carbon source may also be one-carbon substrates such as carbon dioxide, or methanol. Glycerol production from single carbon sources (e.g., methanol, formaldehyde, or formate) has been reported in methylotrophic yeasts (Yamada et al., Agric. Biol. Chem., 53(2) 541-543, 1989, which is hereby incorporated by reference in its entirety, particularly with respect to carbon sources) and in bacteria (Hunter et. al., Biochemistry, 24, 4148-4155, 1985, which is hereby incorporated by reference in its entirety, particularly with respect to carbon sources). These organisms can assimilate single carbon compounds, ranging in oxidation state from methane to formate, and produce glycerol. The pathway of carbon assimilation can be through ribulose monophosphate, through serine, or through xylulose-momophosphate (Gottschalk, Bacterial Metabolism, Second Edition, Springer-Verlag: New York, 1986, which is hereby incorporated by reference in its entirety, particularly with respect to carbon sources). The ribulose monophosphate pathway involves the condensation of formate with ribulose-5-phosphate to form a six carbon sugar that becomes fructose and eventually the three carbon product glyceraldehyde-3-phosphate. Likewise, the serine pathway assimilates the one-carbon compound into the glycolytic pathway via methylenetetrahydrofolate.
In addition to one and two carbon substrates, methylotrophic organisms are also known to utilize a number of other carbon containing compounds such as methylamine, glucosamine and a variety of amino acids for metabolic activity. For example, methylotrophic yeast are known to utilize the carbon from methylamine to form trehalose or glycerol (Bellion et al., Microb. Growth Cl Compd., Int. Symp., 7th ed., 415-32. Editors: Murrell et al., Publisher: Intercept, Andover, UK, 1993, which is hereby incorporated by reference in its entirety, particularly with respect to carbon sources). Similarly, various species of Candida metabolize alanine or oleic acid (Sulter et al., Arch. Microbiol. 153(5), 485-9, 1990, which is hereby incorporated by reference in its entirety, particularly with respect to carbon sources).
In some embodiments, cells are cultured in a standard medium containing physiological salts and nutrients (see, e.g., Pourquie, J. et al., Biochemistry and Genetics of Cellulose Degradation, eds. Aubert et al., Academic Press, pp. 71-86, 1988; and Ilmen et al., Appl. Environ. Microbiol. 63:1298-1306, 1997, hereby incorporated by reference, particularly with respect to cell media). Exemplary growth media are common commercially prepared media such as Luria Bertani (LB) broth, Sabouraud Dextrose (SD) broth, or Yeast medium (YM) broth. One skilled in the art of microbiology or fermentation science would know other defined or synthetic growth media that may also be used, and the appropriate medium for growth of particular host cells.
In addition to an appropriate carbon source, the cell medium desirably contains suitable minerals, salts, cofactors, buffers, and other components known to those skilled in the art suitable for the growth of the cultures or the enhancement of isoprene production (see, for example, WO 2004/033646 and references cited therein and WO 96/35796 and references cited therein, which are each hereby incorporated by reference in their entireties, particularly with respect to cell medias and cell culture conditions). In some embodiments where an isoprene synthase, DXS, IDI, and/or MVA pathway nucleic acid is under the control of an inducible promoter, the inducing agent (e.g., a sugar, metal salt or antimicrobial), is desirably added to the medium at a concentration effective to induce expression of an isoprene synthase, DXS, IDI, and/or MVA pathway polypeptide. In some embodiments, cell medium has an antibiotic (such as kanamycin) that corresponds to the antibiotic resistance nucleic acid (such as a kanamycin resistance nucleic acid) on a vector that has one or more DXS, IDI, or MVA pathway nucleic acids.
Other exemplary cell culture media that can be used are described in US Pub. 2009/0203102, WO 2009/076676, WO 2010/003007, WO 2009/132220, WO 2010/031062, WO 2010/031068, WO 2010/031076, WO 2010/031077, and WO 2010/031079.
Exemplary Production of Isoprene
In some embodiments, the cells are cultured in a culture medium under conditions permitting the production of isoprene by the cells. In some embodiments, the cells in culture produce isoprene at greater than or about 1, 10, 25, 50, 100, 150, 200, 250, 300, 400, 500, 600, 700, 800, 900, 1,000, 1,250, 1,500, 1,750, 2,000, 2,500, 3,000, 4,000, 5,000, or more nmole of isoprene/gram of cells for the wet weight of the cells/hour (nmole/gwcm/hr). In some embodiments, the amount of isoprene is between about 2 to about 5,000 nmole/gwcm/hr, such as between about 2 to about 100 nmole/gwcm/hr, about 100 to about 500 nmole/gwcm/hr, about 150 to about 500 nmole/gwcm/hr, about 500 to about 1,000 nmole/gwcm/hr, about 1,000 to about 2,000 nmole/gwcm/hr, or about 2,000 to about 5,000 nmole/gwcm/hr. The amount of isoprene in units of nmole/gwcm/hr can be measured as disclosed in U.S. Pat. No. 5,849,970, which is hereby incorporated by reference in its entirety, particularly with respect to the measurement of isoprene production. For example, two mL of headspace (e.g., headspace from a culture such as 2 mL of culture cultured in sealed vials at 32° C. with shaking at 200 rpm for approximately 3 hours) are analyzed for isoprene using a standard gas chromatography system, such as a system operated isothermally (85° C.) with an n-octane/porasil C column (Alltech Associates, Inc., Deerfield, Ill.) and coupled to a RGD2 mercuric oxide reduction gas detector (Trace Analytical, Menlo Park, Calif.) (see, e.g., Greenberg et al, Atmos. Environ. 27A: 2689-2692, 1993; Silver et al., Plant Physiol. 97:1588-1591, 1991, which are each hereby incorporated by reference in their entireties, particularly with respect to the measurement of isoprene production). The gas chromatography area units are converted to nmol isoprene via a standard isoprene concentration calibration curve. In some embodiments, the value for the grams of cells for the wet weight of the cells is calculated by obtaining the A600 value for a sample of the cell culture, and then converting the A600 value to grams of cells based on a calibration curve of wet weights for cell cultures with a known A600 value. In some embodiments, the grams of the cells is estimated by assuming that one liter of broth (including cell medium and cells) with an A600 value of 1 has a wet cell weight of 1 gram. The value is also divided by the number of hours the culture has been incubating for, such as three hours.
In some embodiments, the cells in culture produce isoprene at greater than or about 1, 10, 25, 50, 100, 150, 200, 250, 300, 400, 500, 600, 700, 800, 900, 1,000, 1,250, 1,500, 1,750, 2,000, 2,500, 3,000, 4,000, 5,000, 10,000, 100,000, or more ng of isoprene/gram of cells for the wet weight of the cells/hr (ng/gwcm/h). In some embodiments, the amount of isoprene is between about 2 to about 5,000 ng/gwcm/h, such as between about 2 to about 100 ng/gwcm/h, about 100 to about 500 ng/gwcm/h, about 500 to about 1,000 ng/gwcm/h, about 1,000 to about 2,000 ng/gwcm/h, or about 2,000 to about 5,000 ng/gwcm/h. The amount of isoprene in ng/gwcm/h can be calculated by multiplying the value for isoprene production in the units of nmole/gwcm/hr discussed above by 68.1 (as described in Equation 5 below).
In some embodiments, the cells in culture produce a cumulative titer (total amount) of isoprene at greater than or about 1, 10, 25, 50, 100, 150, 200, 250, 300, 400, 500, 600, 700, 800, 900, 1,000, 1,250, 1,500, 1,750, 2,000, 2,500, 3,000, 4,000, 5,000, 10,000, 50,000, 100,000, or more mg of isoprene/L of broth (mg/L broth, wherein the volume of broth includes the volume of the cells and the cell medium). In some embodiments, the amount of isoprene is between about 2 to about 5,000 mg/L broth, such as between about 2 to about 100 mg/L broth, about 100 to about 500 mg/L broth, about 500 to about 1,000 mg/L broth, about 1,000 to about 2,000 mg/L broth, or about 2,000 to about 5,000 mg/L broth. The specific productivity of isoprene in mg of isoprene/L of headspace from shake flask or similar cultures can be measured by taking a 1 ml sample from the cell culture at an OD600 value of approximately 1.0, putting it in a 20 mL vial, incubating for 30 minutes, and then measuring the amount of isoprene in the headspace. If the OD600 value is not 1.0, then the measurement can be normalized to an OD600 value of 1.0 by dividing by the OD600 value. The value of mg isoprene/L headspace can be converted to mg/Lbroth/hr/OD600 of culture broth by multiplying by a factor of 38. The value in units of mg/Lbroth/hr/OD600 can be multiplied by the number of hours and the OD600 value to obtain the cumulative titer in units of mg of isoprene/L of broth.
The instantaneous isoprene production rate in mg/L broth/hr in a fermentor can be measured by taking a sample of the fermentor off-gas, analyzing it for the amount of isoprene (in units such as mg of isoprene per L of gas), and multiplying this value by the rate at which off-gas is passed though each liter of broth (e.g., at 1 vvm (volume of air/volume of broth/minute) this is 60 Lgas per hour). Thus, an off-gas level of 1 mg/Lgas corresponds to an instantaneous production rate of 60 mg/Lbroth/hr at air flow of 1 vvm. If desired, the value in the units mg/Lbroth/hr can be divided by the OD600 value to obtain the specific rate in units of mg/Lbroth/hr/OD. The average value of mg isoprene/Lgas can be converted to the total product productivity (grams of isoprene per liter of fermentation broth, mg/Lbroth) by multiplying this average off-gas isoprene concentration by the total amount of off-gas sparged per liter of fermentation broth during the fermentation. Thus, an average off-gas isoprene concentration of 0.5 mg/Lbroth/hr over 10 hours at 1 vvm corresponds to a total product concentration of 300 mg isoprene/Lbroth.
In some embodiments, the cells in culture convert greater than or about 0.0015, 0.002, 0.005, 0.01, 0.02, 0.05, 0.1, 0.12, 0.14, 0.16, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9, 1.0, 1.2, 1.4, or 1.6% of the carbon in the cell culture medium into isoprene. In some embodiments, the percent conversion of carbon into isoprene is between about 0.002 to about 1.6%, such as about 0.002 to about 0.005%, about 0.005 to about 0.01%, about 0.01 to about 0.05%, about 0.05 to about 0.15%, 0.15 to about 0.2%, about 0.2 to about 0.3%, about 0.3 to about 0.5%, about 0.5 to about 0.8%, about 0.8 to about 1.0%, or about 1.0 to about 1.6%. The percent conversion of carbon into isoprene (also referred to as “% carbon yield”) can be measured by dividing the moles carbon in the isoprene produced by the moles carbon in the carbon source (such as the moles of carbon in batched and fed glucose and yeast extract). This number is multiplied by 100% to give a percentage value (as indicated in Equation 1).

% Carbon Yield=(moles carbon in isoprene produced)/(moles carbon in carbon source)*100  Equation 1

For this calculation, yeast extract can be assumed to contain 50% w/w carbon.

% Carbon Yield=(39.1 g isoprene*1/68.1 mol/g*5 C/mol)/[(181221 g glucose*1/180 mol/g*6 C/mol)+(17780 g yeast extract*0.5*1/12 mol/g)]*100=0.042%  Equation 2

One skilled in the art can readily convert the rates of isoprene production or amount of isoprene produced into any other units. Exemplary equations are listed below for interconverting between units.
Units for Rate of Isoprene Production (Total and Specific)

1 g isoprene/Lbroth/hr=14.7 mmol isoprene/Lbroth/hr (total volumetric rate)  Equation 3

1 nmol isoprene/gwcm/hr=1 nmol isoprene/Lbroth/hr/OD600 (This conversion assumes that one liter of broth with an OD600 value of 1 has a wet cell weight of 1 gram.)  Equation 4

1 nmol isoprene/gwcm/hr=68.1 ng isoprene/gwcm/hr (given the molecular weight of isoprene)  Equation 5

1 nmol isoprene/Lgas O2/hr=90 nmol isoprene/Lbroth/hr (at an O2 flow rate of 90 L/hr per L of culture broth)  Equation 6

1 μg isoprene/Lgas isoprene in off-gas=60 μg isoprene/Lbroth/hr at a flow rate of 60 Lgas per Lbroth (1 vvm)  Equation 7

Units for Titer (total and specific)

1 nmol isoprene/mg cell protein=150 nmol isoprene/Lbroth/OD600 (This conversion assumes that one liter of broth with an OD600 value of 1 has a total cell protein of approximately 150 mg) (specific productivity)  Equation 8

1 g isoprene/Lbroth=14.7 mmol isoprene/Lbroth (total titer)  Equation 9

If desired, Equation 10 can be used to convert any of the units that include the wet weight of the cells into the corresponding units that include the dry weight of the cells.

Dry weight of cells=(wet weight of cells)/3.3  Equation 10

In some embodiments encompassed by the invention, a cell comprising a heterologous nucleic acid encoding an isoprene synthase polypeptide produces an amount of isoprene that is at least or about 2-fold, 3-fold, 5-fold, 10-fold, 25-fold, 50-fold, 100-fold, 150-fold, 200-fold, 400-fold, or greater than the amount of isoprene produced from a corresponding cell grown under essentially the same conditions without the heterologous nucleic acid encoding the isoprene synthase polypeptide.
In some embodiments encompassed by the invention, a cell comprising a heterologous nucleic acid encoding an isoprene synthase polypeptide and one or more heterologous nucleic acids encoding a DXS, IDI, and/or MVA pathway polypeptide produces an amount of isoprene that is at least or about 2-fold, 3-fold, 5-fold, 10-fold, 25-fold, 50-fold, 100-fold, 150-fold, 200-fold, 400-fold, or greater than the amount of isoprene produced from a corresponding cell grown under essentially the same conditions without the heterologous nucleic acids.
Exemplary Isoprene Purification Methods
In some embodiments, any of the methods described herein further include recovering the isoprene. For example, the isoprene produced using the compositions and methods of the invention can be recovered using standard techniques. such as gas stripping, fractionation, adsorption/desorption, pervaporation, thermal or vacuum desorption of isoprene from a solid phase, or extraction of isoprene immobilized or absorbed to a solid phase with a solvent (see, for example, U.S. Pat. Nos. 4,703,007 and 4,570,029, which are each hereby incorporated by reference in their entireties, particularly with respect to isoprene recovery and purification methods). In some embodiments, the recovery of isoprene involves the isolation of isoprene in a liquid form (such as a neat solution of isoprene or a solution of isoprene in a solvent). Gas stripping involves the removal of isoprene vapor from the fermentation off-gas stream in a continuous manner. Such removal can be achieved in several different ways including, but not limited to, adsorption to a solid phase, partition into a liquid phase, or direct condensation. In some embodiments, membrane enrichment of a dilute isoprene vapor stream above the dew point of the vapor resulting in the condensation of liquid isoprene.
The recovery of isoprene may involve one step or multiple steps. In some embodiments, the removal of isoprene vapor from the fermentation off-gas and the conversion of isoprene to a liquid phase are performed simultaneously. For example, isoprene can be directly condensed from the off-gas stream to form a liquid. In some embodiments, the removal of isoprene vapor from the fermentation off-gas and the conversion of isoprene to a liquid phase are performed sequentially. For example, isoprene may be adsorbed to a solid phase and then extracted from the solid phase with a solvent.
In some embodiments, any of the methods described herein further include purifying the isoprene. For example, the isoprene produced using the compositions and methods of the invention can be purified using standard techniques. Purification refers to a process through which isoprene is separated from one or more components that are present when the isoprene is produced. In some embodiments, the isoprene is obtained as a substantially pure liquid. Examples of purification methods include (i) distillation from a solution in a liquid extractant and (ii) chromatography. As used herein, “purified isoprene” means isoprene that has been separated from one or more components that are present when the isoprene is produced. See, e.g. U.S. Patent Application Publication No. 2009/0203102, PCT publication WO 2009/076676 and U.S. patent application Ser. No. 12/496,573. In some embodiments, the isoprene is at least about 20%, by weight, free from other components that are present when the isoprene is produced. In various embodiments, the isoprene is at least or about 25%, 30%, 40%, 50%, 60%, 70%, 75%, 80%, 90%, 95%, or 99%, by weight, pure. Purity can be assayed by any appropriate method, e.g., by column chromatography, HPLC analysis, or GC-MS analysis.
All publications and patents mentioned in the above specification are herein incorporated by reference. Various modifications and variations of the described method and system of the invention will be apparent to those skilled in the art without departing from the scope and spirit of the invention. Although the invention has been described in connection with specific embodiments, it should be understood that the invention as claimed should not be unduly limited to such specific embodiments. It is also to be understood that one, some, or all of the properties of the various embodiments described herein may be combined to form other embodiments of the present invention. These and other aspects of the invention will become apparent to one of skill in the art.
EXAMPLES
The examples, which are intended to be purely exemplary of the invention and should therefore not be considered to limit the invention in any way, also describe and detail aspects and embodiments of the invention discussed above. Unless indicated otherwise, temperature is in degrees Centigrade and pressure is at or near atmospheric. The foregoing examples and detailed description are offered by way of illustration and not by way of limitation. All publications, patent applications, and patents cited in this specification are herein incorporated by reference as if each individual publication, patent application, or patent were specifically and individually indicated to be incorporated by reference. In particular, all publications cited herein are expressly incorporated herein by reference for the purpose of describing and disclosing compositions and methodologies which might be used in connection with the invention. Although the foregoing invention has been described in some detail by way of illustration and example for purposes of clarity of understanding, it will be readily apparent to those of ordinary skill in the art in light of the teachings of this invention that certain changes and modifications may be made thereto without departing from the spirit or scope of the appended claims.
Example 1
Construction of MBD Kudzu IspS
This example describes construction of a vector expressing a maltose-binding protein-kudzu isoprene synthase fusion molecule.
I. Construction of pTrcKudzu
A synthetic gene, coding for isoprene synthase (IspS) of the kudzu vine (Pueraria lobata) and codon-optimized for E. coli, was purchased from DNA2.0 (Menlo Park, Calif.) and provided as plasmid p9795 (FIGS. 2 and 3). The Insert was been removed by digestion with BspLU11I/PstI, gel-purified, and religated into NcoI/PstI-digested pTrcHis2B (Invitrogen, Carlsbad, Calif.). The resulting plasmid was named pTrcKudzu (FIGS. 4 and 5). The stop codon in the insert is before the PstI site, which results in a construct in which the His-Tag is not attached to the IspS protein.
II. Construction of Plasmid pMAL-C4X Kudzu
A PCR reaction was performed to amplify the E. coli codon-optimized kudzu gene using plasmid pTrcKudzu as the DNA template, primers EL-959 and EL-960 Table 1-1, 10 mM dNTP (Roche, Indianapolis, Ind.), and Pfu Ultra II Fusion DNA polymerase (Stratagene, La Jolla, Calif.) according to manufacturer's protocol. PCR conditions were as follows: 95° C. for 2 min (first cycle only), 95° C. for 25 sec, 60° C. for 25 sec, 72° C. for 30 sec, and repeat for 28 cycles, with final extension at 72° C. for 1 min. The PCR product was then purified using the QIAquick PCR Purification Kit (Qiagen Inc, Valencia, Calif.).
The kudzu PCR product (1 μg) was digested using EcoRI and HindIII restriction endonucleases (Roche) according to manufacturer's protocol. The digest was incubated 37° C. for 30 minutes to minimize digestion of the internal EcoRI site that is present in the kudzu gene. The digested PCR fragment was then purified using the QIAquick PCR Purification Kit. The vector pMAL-C4X (0.5 μg) (New England Biolabs, Ipswich, Mass.; FIGS. 6 and 7) was digested using EcoRI and HindIII restriction endonucleases (Roche) according to manufacturer's protocol. The digested vector was then gel purified using the QIAquick Gel Extraction Kit (Qiagen Inc). A DNA ligation reaction was performed using T4 DNA ligase (New England Biolabs) with a 5:1 ratio of digested kudzu PCR product to digested pMAL-C4X vector according to manufacturer's protocol. An aliquot of the ligation reaction was then transformed into TOP10 chemically competent cells (Invitrogen Corp). Transformants were selected on LA+50 μg/μl carbenicillin plates.
Screening of transformants containing the kudzu gene was performed by picking colonies and performing PCR with primers EL-957 and EL-966 using PuReTaq Ready-To-Go PCR beads (GE Healthcare, Piscataway, N.J.) according to manufacturer's protocol. PCR conditions were as follows: 95° C. for 2 min (first cycle only), 95° C. for 30 sec, 50° C. for 30 sec, 72° C. for 40 sec, and repeat for 28 cycles, with final extension at 72° C. for 1 min. PCR products were analyzed on a 2% E-gel (Invitrogen Corp) looking for a 600 by fragment. Colonies containing the correct sized PCR product insert were submitted for DNA sequencing using primers EL-950, EL-951, EL-953, and EL-957. DNA sequencing confirmed the construction of plasmid pMAL-C4X Kudzu (FIGS. 8 and 9).







TABLE 1-1







Primer sequences








Primer



name
Primer sequence





EL-950
CGGTGAACTGAAAGGTGACGTCC



(SEQ ID NO: 22)


 


EL-951
GGACGTTAACGCTATTAACACCCTG



(SEQ ID NO: 23)


 


EL-953
CACATCGTCGATCAGCTCCAGC



(SEQ ID NO: 24)


 


EL-957
GGTCGTCAGACTGTCGATGAAGCC



(SEQ ID NO: 25)


 


EL-959
GCTTATGAATTCTGTGCGACCTCTTCTCAATTTACTCAG



(SEQ ID NO: 26)


 


EL-960
GCTTATAAGCTTAGACATACATCAGCTGGTTAATCGGG



(SEQ ID NO: 27)


 


EL-966
CTCCTCCAGCAGGTTCTCACC



(SEQ ID NO: 28)









III. Expression Strain MBP-Kudzu

Plasmid pMAL-C4X Kudzu was transformed into OneShot BL21(λDE3) chemically competent cells (Invitrogen Corp). Expression strain transformants were selected on LA+50 mg/ml carbenicillin plates.
Example 2
IspS Variants for Crystal Structure Trials
This example describes methods to generate affinity tagged isoprene synthase (IspS) enzymes for expression, purification and crystallization.
I. Strain Construction
For constructs in the pET200D-TOPO vector (Invitrogen), PCR products of the IspS enzymes from P. alba, P. tremuloides, and P. trichocharpa were gel extracted and purified (Qiagen), using 0.8% E-gel (Invitrogen), according to the manufacturer's recommended protocol. PCR reactions for pET200 constructs are as follows: Reaction mixture was 1 μl (Templates)-pET24a-P. alba, 5 μl 10×PfuUltraII Fusion buffer, 1 μl dNTP's (10 mM), 1 μl primer (50 uM) primer F-(MCM219 or 218), 1 μl primer (50 uM) primer R-(MCM182), 41 μl diH2O and 1 μl of PfuUltra II Fusion DNA Polymerase from Stratagene; Cycle Parameter were 95° C. 1 min., 95° C. 1 min, 55° C. 20 sec., 72° C. 27 sec. for 29 cycles followed by 72° C. for 3 min and then 4° C. until cool, using an Eppendorf Mastercycler. Similar reactions were performed for P. tremuloides, P. trichocarpa, and kudzu. 3 μl of purified product was then ligated to the pET200D/TOPO vector (Invitrogen), according to the manufacturer's protocol. The reaction was incubated for 5 minutes at room temperature, and the 6 μl topoisomerase mixture was then transformed into E. coli Top10 chemically competent cells (Invitrogen) according to the manufacturer's protocol. Transformants were selected for on LB Kan50, and incubated at 37° C. overnight. Five colonies per construct were chosen and screened using PuReTaq Ready-To-Go PCR Beads (Amersham) using the T7 Forward and MCM182 primers (Table 2-1). Clones harboring inserts of the correct size were further verified by plasmid miniprep using the QIAPrep Spin Miniprep kit (Qiagen) followed by sequencing using the T7 Forward and T7 Reverse primers (Quintara Biosciences). One fully sequenced construct for each IspS variant (FIGS. 10-14), was chosen for further study. 1 μl of each plasmid was transformed into BL21(λDE3) pLysS (Invitrogen) according to the manufacturer's protocol. Transformants were selected for on LB medium with Kan50+Cm35 and incubated at 37° C. overnight. The resulting strains were used for expression and purification of various IspS enzymes for crystallography studies.
Construction of an N-terminally 6×His-tagged IspS (in pDu27, see FIG. 22) for protein purification was prepared as follows. The following PCR Reaction mixture was used: 1 μl (Template)-P. alba pET24a, 5 μl 10×PfuUltraII Fusion buffer, 1 μl dNTP's (10 mM), 1 μl primer (50 uM) primer F-(MCM219), 1 μl primer (50 uM) primer R-(MCM182) (Table 2-1), 41 μl diH2O and 1 μl of PfuUltra II Fusion DNA Polymerase (Stratagene). PCR Cycling Parameters were as follows: 95° C. 1 min., 95° C. 1 min, 55° C. 20 sec., 72° C. 27 sec. for 29 cycles followed by 72° C. for 3 min and 4° C. until cool, using an Eppendorf Mastercycler. The PCR product of the full length P. alba IspS (from the template P. alba pET24a, FIG. 24) was gel extracted and purified, using 0.8% E-gel (Invitrogen) and Qiagen QIAquick Gel Extraction and QIAprep Spin Miniprep kits, according to the manufacturer's recommended protocol. A 3 μl aliquot of purified product was ligated to the pET200D/TOPO vector (Invitrogen), according to the manufacturer's protocol. The reaction was incubated for 5 minutes at room temperature, and the 6 μl topoisomerase mixture was then transformed into E. coli Top10 chemically competent cells (Invitrogen) according to the manufacturer's protocol. Transformants were selected for on LB plates containing kanamycin (50 ug/ml) (Kan50), and incubated at 37° C. overnight. Five colonies were picked and screened using PuReTaq Ready-To-Go PCR Beads (Amersham) using the T7 Forward and MCM182 primers (Table 2-1). Clones harboring inserts of the correct size were further verified by sequencing using the T7 Forward and T7 Reverse primers (Quintara Biosciences). One construct, pDu27 (see FIG. 22), was chosen for further study. A 1 μl aliquot of the plasmid preparation was transformed into BL21(λDE3)pLysS (Invitrogen) according to the manufacturer's protocol. Transformants were selected for on LB plates containing Kan50+ and chloramphenicol (35 μg/ml) (Cm35) and incubated at 37° C. overnight. The resulting strain was used for expression and purification of N-terminally 6×His-tagged P. alba IspS.
Constructs with affinity (6×His) and proteolysis (TEV, Tobacco Etch Virus) tags were generated using P. alba pET24a as a template for PCR reactions. PCR reaction mixtures were prepared as follows: 1 ul (P. alba pET24a), 5 ul 10× PfuUltraII Fusion buffer, 1 ul dNTP's (10 mM), 1 ul primer (50 uM) Alba FL-NdeI-For or Alba TRC (MEA)-NdeI-F, 1 ul primer (50 uM) Alba FLTRC (+) TEV-R, 41 ul diH2O and 1 ul of PfuUltra II Fusion DNA Polymerase from Stratagene. PCR cycling parameters were as follows: 95° C. 1 min., 95° C. 30 sec., 55° C. 20 sec., 72° C. 25 sec. for one cycle and then repeating 95° C. 30 sec., 55° C. 20 sec., 72° C. 25 sec. for an additional 28 cycles, followed by 72° C. 3 min and then 4° C. After amplification and verification of the correct molecular weight of the product by visualization on 0.8% E-gel (Invitrogen), PCR products were digested with restriction enzymes NdeI and XhoI (Roche) for 2 hours at 37° C., and then gel purified using the Qiaquick Gel Purification system (Qiagen) according to the manufacturer's recommended protocol. 3 ul of purified product was ligated to pET-24a (Invitrogen) that was digested with NdeI and XhoI (Roche), gel purified and dephosphorylated (using SAP, shrimp alkaline phosphatase) (Promega) according to the manufacturer's recommended protocols. T4 ligase (NEB) was used for the ligation reaction, which was incubated overnight at 16° C. The ligation reaction was dialyzed into water for 30 min., and 2 μl of the reaction was used to electroporate MCM331 (see below) competent cells. Cells were allowed to recover at 30° C. for 2 hours, and then selected on Kan50 with 5 mM (R)-(−)-Mevalonolactone (MVA) (Sigma) spread onto the plate. Positive transformants were inoculated into 3 ml of liquid LB Kan50, and plasmids were isolated using the QIAPrep Spin miniprep kit (Qiagen). Inserts were verified by restriction digestion using NdeI and XhoI (Roche) and positive clones were sequenced (Quintara Biosciences) with T7 promoter and T7 terminator sequencing primers. 1 μl of each plasmid (see Table 2-3 for plasmid description; FIGS. 15-29) was transformed into chemically competent E. coli BL21(λDE3) pLysS (Invitrogen) according to the manufacturer's recommended protocol. Transformants were selected on LB Kan50+Cm35 (Chloramphenicol 35 ug/ml) plates and incubated at 37° C. See Table 2-4 for a description of all expression strains.
Preparation of strain MCM331
Strain MCM331 was prepared as follows. A synthetic operon containing mevalonate kinase, mevalonate phosphate kinase, mevalonate pyrophosphate decarboxylase, and the IPP isomerase was integrated into the chromosome of E. coli. If desired, expression may be altered by integrating different promoters 5′ of the operon.
i) Target Vector Construction
The attTn7 site was selected for integration. Regions of homology upstream (attTn7 up) (primers MCM78 and MCM79; Table 2-2) and downstream (attTn7 down) (primers MCM88 and MCM89) were amplified by PCR from MG1655 cells. A 50 μL reaction with 1 μL 10 μM primers, 3 μL ddH2O, 45 μL Invitrogen Platinum PCR Supermix High Fidelity, and a scraped colony of MG1655 was denatured for 2:00 at 94° C., cycled 25 times (2:00 at 94° C., 0:30 at 50° C., and 1:00 at 68° C.), extended for 7:00 at 72° C., and cooled to 4° C. This resulting DNA was cloned into pCR2.1 (Invitrogen) according to the manufacturer's instructions, resulting in plasmids MCM278 (attTn7 up) and MCM252 (attTn7 down). The 832 by ApaI-PvuI fragment digested and gel purified from MCM252 was cloned into ApaI-PvuI digested and gel purified plasmid pR6K, creating plasmid MCM276. The 825 bp PstI-NotI fragment digested and gel purified from MCM278 was cloned into PstI-NotI digested and gel purified MCM276, creating plasmid MCM281.
ii) Cloning of Lower Pathway and Promoter
MVK-PMK-MVD-IDI genes were amplified from pTrcKKDyIkIS with primers MCM104 and MCM105 using Roche Expand Long PCR System according to the manufacturer's instructions. This product was digested with NotI and ApaI and cloned into MCM281 which had been digested with NotI and ApaI and gel purified. Primers MCM120 and MCM127 were used to amplify CMR cassette from the GeneBridges FRT-gb2-Cm-FRT template DNA using Stratagene Pfu Ultra II. A PCR program of denaturing at 95° C. for 4:00, 5 cycles of 95° C. for 0:20, 55° C. for 0:20, 72° C. for 2:00, 25 cycles of 95° C. for 0:20, 58° C. for 0:20, 72° C. for 2:00, 72° C. for 10:00, and then cooling to 4° C. was used with four 50 μL PCR reactions containing 1 uL ̃10 ng/μL template, 1 μL each primer, 1.25 μL 10 mM dNTPs, 5 μL 10× buffer, 1 μL enzyme, and 39.75 μL ddH20. Reactions were pooled, purified on a Qiagen PCR cleanup column, and used to electroporate water-washed Pir1 cells containing plasmid MCM296. Electroporation was carried out in 2 mM cuvettes at 2.5V and 200 ohms. Electroporation reactions were recovered in LB for 3 hr at 30° C. Transformant MCM330 was selected on LA with CMP5, Kan50.
iii) Integration into E. coli Chromosome
Miniprepped DNA (Qiaquick Spin kit) from MCM330 was digested with SnaBI and used to electroporate BL21(DE3) (Novagen) or MG1655 containing GeneBridges plasmid pRedET Carb. Cells were grown at 30° C. to  ̃OD1 then induced with 0.4% L-arabinose at 37° C. for 1.5 hours. These cells were washed three times in 4 C ddH2O before electroporation with 2 μL of DNA. Integrants were selected on L agar with containing chloramphenicol (5 μg/ml) and subsequently confirmed not to grow on L agar+Kanamycin (50 μg/ml). BL21 integrant MCM331 and MG1655 integrant MCM333 were frozen.







TABLE 2-1





Primers


















MCM219
caccatgcgttgtagcgtgtcca




(SEQ ID NO: 29)



 



MCM182
gggcccgtttaaactttaactagactctgcagttagcg




ttcaaacggcagaa




(SEQ ID NO: 30)



 



MCM218
caccatgcgtcgttctgcgaactac




(SEQ ID NO:31)

















TABLE 2-2





Primers of construction of MCM331

















MCM78
attTn7 up rev for integration
gcatgctcgagcggccgcTTTTAATCAAACATCCTGCCAACTC



construct
(SEQ ID NO: 32)


 


MCM79
attTn7 down rev for integration
gatcgaagggcgatcgTGTCACAGTCTGGCGAAACCG



construct
(SEQ ID NO: 33)


 


MCM88
attTn7 up forw for integration
ctgaattctgcagatatcTGTTTTTCCACTCTTCGTTCACTTT



construct
(SEQ ID NO: 34)


 


MCM89
attTn7 down forw for
tctagagggcccAAGAAAAATGCCCCGCTTACG



integration construct
(SEQ ID NO: 35)


 


MCM104
GI1.2 promoter-MVK
Gatcgcggccgcgcccttgacgatgccacatcctgagcaa




Ataattcaaccactaattgtgagcggataacacaaggagg




Aaacagctatgtcattaccgttcttaacttc




(SEQ ID NO: 36)


 


MCM105
aspA terminator-yIDI
Gatcgggccccaagaaaaaaggcacgtcatctgacgtgcc




Ttttttatttgtagacgcgttgttatagcattcta




(SEQ ID NO: 37)


 


MCM120
Forward of attTn7: attTn7
aaagtagccgaagatgacggtttgtcacatggagtt



homology, GB marker
ggcaggatgtttgattaaaagcAATTAACCCTCACTA



homology
AAGGGCGG




(SEQ ID NO: 38)


 


MCM127
Rev complement of 1.2 GI: GB
AGAGTGTTCACCAAAAATAATAACCTTTCCCGGTGCAgaa



marker homology(extra long),
Gttaagaacggtaatgacatagctgtttcctccttgtgtt



promoter, RBS, ATG
Atccgctcacaattagtggttgaattatttgctcaggatg




tggcatcgtcaagggcTAATACGACTCACTATAGGGCTCG




(SEQ ID NO: 39)
















TABLE 2-3





Plasmids
















P. alba pET24a
pET24a with “full length” IspS from P. alba


P. trichocharpa pET24a
pET24a with “full length” IspS from



P. trichocharpa


P. tremuloides pET24a
pET24a with “full length” IspS from



P. tremuloides


MBP-Kudzu


pDu27
P. alba FL-pET200/Top 10


pDu30
P. alba TRC-pET200/Top10


pDu31
P. trem TRC-pET200/Top 10


pDu32
P. trich TRC-pET200/Top10


MD09-161
pET24a-P.alba FL C-Term (+) TEV,



His tag/MCM331


MD09-163
pET24a-P.alba TRC (MEA) C-Term (+) TEV,



His tag/MCM331
















TABLE 2-4







Strains









MBP-Kudzu














MD08-99
BL21 DE3 pLys + pDu27



MD08-100
BL21 DE3 pLys + pDu30



MD08-102
BL21 DE3 pLys + pDu31



MD08-104
BL21 DE3 pLys + pDu32



MD09-165
BL21(DE3)pLysS, pET24a-P.alba




FL C-Term (+) TEV, His tag



MD09-167
BL21(DE3) pLysS, pET24a-P.alba




TRC (MEA) C-Term (+) TEV, His tag










II. Purification of 6×His-Tagged IspS

Expression of 6×His-Tagged IspS

N-terminally 6×His-tagged IspS was expressed and purified from strain MD08-99. The growth procedure is suitable for histidine tagged enzymes expressed in BL21(λDE3)pLysS cells. A 10 ml of overnight culture was prepared for each 1 L of planned growth. The appropriate antibiotics (50 mg/ml kanamycin, 50 mg/ml chloramphenicol, and/or 50 mg/ml Carbenecillin) was added to 10 ml of LB medium in a 25 ml flask and was inoculated with 1 colony from a fresh plate of cells or directly from glycerol frozen cell stock. Cultures were grown at 30° C. overnight with shaking at  ̃220 rpm. Day cultures were prepared in 1 liter of LB medium with appropriate antibiotics for each culture. Each 1 L Day culture was inoculated with 10 ml of overnight culture and grown at 30-37° C. with shaking at  ̃220 rpm until the OD600 reached  ̃0.4-0.6. Day cultures were then induced with 400 μM IPTG and allowed to continue growing at 30° C. with shaking at 220 rpm for  ̃5-6 hours. Cells were then harvested by centrifugation at 10,000×g for 10 min, 4° C. Following Harvest, cells were used directly or stored at −80° C. until ready to process.
Purification of 6×His-Tagged IspS
For purification of histidine tagged enzymes from BL21(λDE3)pLysS cells, cells were gently resuspended in fresh Lysis buffer (Lysis buffer: Ni wash buffer+0.5 mM PMST, 0.01% Tween-20, 1 mg/ml lysozyme, 0.2 mg/ml DNaseI; Ni wash buffer: 50 mM NaH2PO4, 300 mM NaCl, 20 mM Imidazole, pH 8.0). Approximately 40-50 ml of lysis buffer was used per 1 L of cell pellet. Cells were then incubated on ice for approximately 30 min. The cell suspension was then lysed fully by passing 2-3 times through a french pressure cell (large french press cell at 1200 psi/High setting) until lysate started to look clear. A sample of the lysate was saved for activity assay and gel analysis ( ̃100 μl). The lysate was then clarified by centrifuging the lysate at 30,000×g for 30 min, 4° C. in a Sorvall Discovery 90SE ultracentrifuge. The supernatant was removed and retained. A sample of the “clarified lysate” was saved for activity assay and gel analysis ( ̃100 μl).
The clarified lysate was run over HisTrap HP columns (GE Healthcare) using a gradient from 0-100% Ni buffer B. Samples were then analyzed by SDS-PAGE gel (4-12% gel NUPAGE, Invitrogen) according to manufacturer's directions. Desired fractions were concentrated on spin filters (Vivaspin-20, Sartoris,) and then desalted over a HiPrep 26/10 Desalting column (GE healthcare) packed with Sephadex G25 resin. The G-25 buffer consisted of 50 mM HEPES, 50 mM NaCl, and 1 mM DTT, pH 7.4. The desired sample was then purified over a HiTrap Q HP column (GE) using a gradient elution from 0% Q seph buffer A to 100% Q seph buffer B (Q seph buffer A: 50 mM Tris, 0.05 M NaCl, 1 mM DTT, pH 7.6 and Q seph buffer B: 50 mM Tris, 1.0 M NaCl, 1 mM DTT, pH 7.6). Fractions containing the desired protein were analyzed and concentrated. Sample buffer was then exchanged into 50 mM HEPES, 50 mM NaCL, pH 7.4 with 1 mM DTT by passing the sample over a Hi Prep 26/10 Desalting column (GE healthcare) packed with Sephadex G25 resin. A final polishing step of Gel filtration was used when necessary. The sample was passed through a Hi Load 26/60 Superdex 200 prep grade (GE) in gel filtration buffer: (50 mM HEPES, 150 mM NaCl, 1 mM DTT, pH 7.4). Fractions were then analyzed and concentrated. The samples were then stored at −80° C. For preparation for analysis of the band, the sample is run on an SDS-PAGE gel (4-12% NUPAGE gel, Invitrogen), stained and the desired band excised and processed as described below.
III. Digestion of TEV (Tobacco Etch Virus) or EK (Enterokinase)-Tagged Enzymes
TEV Cleavage (IspS from Strains MD09-165 and MD09-167)
For digestion, enzymes were purified through a Ni charged sepharose (GE Healthcare) and desalted into 50 mM HEPES, 50 mM NaCl pH 7.4 buffer containing 1 mM DTT. Digestion was performed with TurboTEV Protease from Eton Bioscience Inc. One unit of TurboTEV per 10 μg of purified protein was used. The digest was performed at 4° C. overnight. Samples were passed through another Ni column equilibrated in the Ni buffer to remove uncleaved enzyme, tag, TurboTEV protease (that is also tagged) and impurities. The Ni column pass though and washes were analyzed using SDS-PAGE gel (NUPAGE, Invitrogen) and DMAPP activity assays. Samples containing pure enzyme were pooled and desalted into 50 mM NaCl pH 7.4 buffer containing 1 mM DTT and stored at −80° C.
EK Cleavage (IspS from Strains MD08-102 and MD08-104)
For digestion enzymes were purified through a Ni charges sepharose (GE Healthcare) and desalted into 50 mM HEPES, 50 mM NaCl pH 7.4 buffer containing 1 mM DTT.
Digestion was performed with EKMax (E180-02) (Invitrogen) using 1 unit of EKMax per 20 ug of purified protein at 4° C. overnight. Samples were passed over EK Away resin (Invitrogen) to remove excess enterokinase. Samples were batched onto Ni charged sepharose resin (equilibrated in the Ni was buffer) and incubated for 30 min at 4° C., with occasional inverting. This removed uncleaved enzyme, tag, and impurities. The Ni column pass though and washes were analyzed using SDS-PAGE gel (4-12% NUPAGE, Invitrogen) and DMAPP activity assays. Samples containing pure enzyme were pooled and desalted into 50 mM NaCl pH 7.4 buffer containing 1 mM DTT. Stored at −80° C.
IV. Purification of MBP-IspS
Construction of pMAL-C4X Kudzu for the expression of MBP-Kudzu isoprene synthase is described in Example 1. MBP-Kudzu isoprene synthase production from E. coli grown in batch culture at the 15-L scale.
Medium Recipe (Per Liter Fermentation Medium):
K2HPO4 7.5 g, MgSO4*7H2O 2 g, citric acid monohydrate 2 g, ferric ammonium citrate 0.3 g, yeast extract 0.5 g, 1000× Modified Trace Metal Solution 1 ml. All of the components were added together and dissolved in diH2O. This solution was autoclaved. The pH was adjusted to 7.0 with ammonium hydroxide (30%) and q.s. to volume. Glucose 10 g, thiamine*HCl 0.1 g, and antibiotics were added after sterilization and pH adjustment.
1000× Modified Trace Metal Solution:
Citric Acids*H2O 40 g, MnSO4*H2O 30 g, NaCl 10 g, FeSO4*7H2O 1 g, CoCl2*6H2O 1 g, ZnSO*7H2O 1 g, CuSO4*5H2O 100 mg, H3BO3 100 mg, NaMoO4*2H2O 100 mg. Each component is dissolved one at a time in diH2O, pH to 3.0 with HCl/NaOH, then q.s. to volume and filter sterilized with 0.22 micron filter.
Fermentation was performed in a 15-L bioreactor with BL21 (DE3) E. coli cells containing the pMAL-C4X plasmid expressing a maltose binding protein (MBP)-Kudzu isoprene synthase fusion molecule. This experiment was carried out to produce isoprene synthase at the desired fermentation pH 7.0 and temperature 30° C. A frozen vial of the E. coli strain was thawed and inoculated into tryptone-yeast extract medium. After the inoculum grew to OD 1.0, measured at 550 nm (OD550), 120 mL was used to inoculate a 15-L bioreactor bringing the initial volume to 9-L.
Expression of the desired molecule was achieved by adding isopropyl-beta-D-1-thiogalactopyranoside (IPTG). The IPTG concentration was brought to 1 mM when the OD550 reached a value of 10. Cells containing the desired product were harvested 3 hrs after IPTG addition.
MBP-IspS Purification
The broth was centrifuged for 15 min at 10000×g. The pellet was collected and frozen at −80° C. until further purification. Cells were resuspended in MBP-Bind Buffer (5% glycerol, 20 mM Tris pH 7.4, 200 mM NaCl, 2 mM DTT, 1 mg/ml lysozyme) and passed through the french press three times at 20000 psi. The lysate was then ultracentrifuged at 100000×g for 1 hour to yield a relatively clear solution. The supernatant was pipetted from the top of the tube without disturbing the gelatinous material on the bottom of the centrifuge tube. Gel filtration was performed on the supernatant using a Superdex-200 26/60 column (GE healthcare). The column was developed using MBP-Bind buffer at a flow rate of 3 mL/min at 23° C. Fractions were tested for DMAPP activity as described below. Active fractions were pooled and loaded onto 25 mL amylose resin (New England Biolabs). The column was washed with 10 column volumes MBP-Bind buffer and the protein was then eluted with 2 column volumes of MBP-Bind buffer containing 10 mM maltose to yield >90% pure MBP-IspS.
V. DMAPP Assay
The following reaction mixture was used for the DMAPP assay: 25 μL lysate mixture, 5 μL MgCl2 (1 M), 5 μL DMAPP (100 mM), and 65 μL 100 mM Tris pH 8, 100 mM NaCl for a total volume of 100 μL. The reaction is performed at 30° C. for 15 minutes in a gas tight 1.8 mL GC tube. Reactions are terminated by the addition of 100 μL 500 mM EDTA (pH 8). The amount of isoprene produced was measured by GC/MS.
The analysis was performed (for the 2 mL and 96-well plate methods) using an Agilent 6890 GC/MS system interfaced with a 5973 MS Leap CTC CombiPAL autosampler operating in headspace mode. An Agilent HP-5 (5% Phenyl Methyl Siloxane (15 m×0.25 mm×0.25 uM)) column was used for separation of analytes. The sampler was set up to inject 100 μL of headspace gas. The GC/MS method utilized helium as the carrier gas at a flow of 1 ml/min. The injection port was held at 250° C. with a split ratio of 50:1. The oven temperature was held at 37° C. for the 2 min duration of the analysis. The Agilent 5793N mass selective detector was run in single ion monitoring (SIM) mode on mass 67. The detector was switched off from 0.00 to 0.44 minutes to allow the elution of permanent gases and on 0.44 mins to 0.60 mins. Under these conditions isoprene (2-methyl-1,3-butadiene) was observed to elute at 0.49 minutes. A calibration table was used to quantify the absolute amount of isoprene and was found to be linear from 0 μg/L to 5600 mg/L (using calibration gas).
Example 3
Three-Dimensional Structure of IspS
Seven constructs of plant isoprene synthase (IspS) were prepared in the hope that one or more would yield crystals suitable for x-ray diffraction. These were: a construct containing N-terminal histidine-tagged maltose binding protein and kudzu IspS (MBP-kudzu), full-length P. alba IspS with N-terminal histidine-tag (MD08-99), P. alba IspS with the first nineteen N-terminal residues removed (MD08-100), this construct also had the N-terminal his-tag removed after purification. Full-length, untagged P. alba IspS (strain RM11608-2). A truncated P. alba IspS construct featuring two additional residues before the twin-arginine motif was generated (MD09-167). P. tricharpa IspS was generated, which contains both an N-terminal his-tag and N-terminal truncation (MD08-104), and another construct composed of IspS from P. tremuloides was generated with an N-terminal his-tag and N-terminal truncation (MD08-102). Construction of strains expressing various isoprene synthases are described above.
Protein from each construct was purified and a concentrated protein solution was then prepared for surveying possible crystallization conditions. Each protein was purified independently and surveyed as described below. All in-house crystallization screens were set up using the hanging drop vapor diffusion method. At a minimum, each protein was surveyed using the following commercial screens: the Crystal Screen from Hampton Research (Aliso Viejo, Calif.) and the JCSG+Suite from Qiagen (Valencia, Calif.).
Purified MBP-kudzu using was set up using the following commercial screens: the Crystal Screen from Hampton Research and the JCSG+Suite from. Additionally, purified MBP-kudzu was sent to the Hauptman-Woodward Institute (Buffalo, N.Y.) for high-throughput screening, where no fewer than 1536 conditions were surveyed. The purified MBP-kudzu fusion precipitated out of solution in the majority of conditions, and no protein crystals were observed.
The next construct used for crystallization screening was MD08-99 (full-length P. alba IspS with N-terminal histidine-tag). MD08-99 was purified and the histidine-tag was removed. The same three initial crystallization screens were performed as for MBP-kudzu. The Hampton Research Crystal Screen and Qiagen JCSG+Suite were each performed at multiple protein concentrations. Small needle-like crystals were observed in some Hampton Research Crystal Screen conditions. Further attempts to improve the crystals involved co-crystallization with the IspS inhibitor sodium ibandronate (Sigma-Aldrich, St Louis, Mo.). Taken together, an additional 288 crystallization conditions were attempted with variations of pH, concentration, and crystallization reagents. The nine best crystals were then prepared for data collection and tested in-house on a Rigaku RU200 rotating anode generator and R-AXIS IV++, and they either did not diffract x-rays or were salt crystals.
The first nineteen N-terminal residues of P. alba IspS were removed to produce construct MD08-100. This construct had the N-terminal histidine-tag removed after purification. In house crystallization screens were performed using the Hampton Research Crystal Screen and Qiagen JCS G+Suite, each with multiple protein concentrations. Initial crystal hits included hexagonal plates that diffracted to 16 Å resolution, and small rods that diffracted to 5 Å resolution using the in-house x-ray generator. In an attempt to improve the crystals, MD08-100 was co-crystallized with either sodium ibandronate or sodium pyrophosphate (Sigma-Aldrich, St Louis, Mo.), both of which are inhibitors of the IspS activity. Neither inhibitor resulted in improved crystals or improved diffraction. An additional 168 crystallization conditions were attempted with variations of pH, concentration, and crystallization reagents. The twenty-one most promising MD08-100 crystals were screened for diffraction, with the best resolution obtained being 5 Å.
Full-length, untagged P. alba IspS (strain RM11608-2) from a fermentation run was purified. An initial screen was set up using the Hampton Research Crystal Screen, and crystals were observed in four different conditions. All four crystals were tested for diffraction in-house, with three being salt crystals and one not diffracting.
A truncated P. alba IspS construct featuring two additional residues before the twin-arginine motif was generated (MD09-167). This construct contains a C-terminal histidine-tag, and crystallization experiments were set up with the tag either cleaved or not cleaved, at varying protein concentrations, and with or without sodium pyrophosphate. Initial crystallization screens were done as per MBP-kudzu. Crystals from this construct were observed in numerous conditions; optimization included 528 variations of pH, precipitating agents, concentrations, and inhibitors. From the optimization experiments, fifteen different MD09-167 crystals were screened in-house for diffraction. In an effort to improve the resolution, various crystal freezing conditions were tested, with the effect of improving the diffraction limits from 10 Å to 6.5 Å.
A new construct containing P. tricharpa IspS was generated, which contains both an N-terminal histidine-tag and an N-terminal truncation (MD08-104). Purified MD08-104 with cleaved histidine-tag was surveyed using the Hampton Research Crystal Screen and the Qiagen JCSG+suite. This construct generated heavier precipitate than the P. alba IspS constructs. Very small needles were observed, with none of the crystals being suitable for diffraction.
Another construct composed of IspS from P. tremuloides was generated with an N-terminal histidine-tag and an N-terminal truncation (MD08-102; SEQ ID NO:11). Purified MD08-102 with and without cleaved histidine-tag was set up using the Hampton Research Crystal Screen and the Qiagen JCSG+Suite at varying protein concentrations. Rod and plate-like crystals were observed in some conditions and an additional 120 experiments were performed to improve the crystals by varying pH, concentration, and crystallization reagents. From the optimization experiments, ten crystals were tested in-house, with the initial best diffraction reaching 5 Å. Upon further modification of the freezing conditions of the crystals, a crystal was found that diffracted to 3.3 Å from the uncleaved histidine-tagged protein. This crystal was grown by mixing 2 μL of protein (10 mg/ml, with 30 mM MgCl2) with 2 μL of precipitant solution [10% (wt/vol) polyethylene glycol 8000, 0.1 M HEPES, pH 7.5, 8% ethylene glycol] and equilibrated against 500 μL of precipitant. A cluster of rod-shaped crystals appeared after three weeks. The crystals belong to the tetragonal space group P43212, and have unit cell dimensions a=154.2, b=154.2, c=142.7.
In-house x-ray diffraction data were collected under a nitrogen stream at 100 K using a Rigaku RU200 generator and R-AXIS IV++ detector. Before flash-freezing the crystal in liquid nitrogen, it was cryoprotected by swiping it through a solution containing 10% (wt/vol) polyethylene glycol 8000, 0.1 M HEPES, pH 7.5, and 25% ethylene glycol. Data were integrated using Mosflm (Leslie, A. (1998) J. of Appl. Crystallography 30, 1036-1040) and scaled using SCALA (Collaborative Computational Project, N. (1994) Acta Crystallographica Section D 50, 760-763). The data were then phased by molecular replacement using MrBUMP (Keegan, R. M., and Winn, M. D. (2007) Acta Crystallographica Section D 63, 447-457; Vagin, A., and Teplyakov, A. (1997) J. of Appl. Crystallography 30, 1022-1025), with a monomer of limonene synthase (Protein Data Bank ID 2ONH) (Berman, H., et al. (2007) Nucl. Acids Res. 35, D301-303) as the starting model. The crystal contains one dimer in the asymmetric unit with a solvent content of 66%.
A 3.05 Å data set from the same crystal was then collected using beamline 11-1 of the Stanford Synchrotron Radiation Laboratory. These data were also processed using Mosflm and SCALA. Data collection and refinement statistics are given in Table 3-1.
Refinement with Refmac5 (Collaborative Computational Project, N. (1994) Acta Crystallographica Section D 50, 760-763) was used with iterative manual rebuilding steps using the visualization program Coot (Emsley, P., and Cowtan, K. (2004) Acta Crystallographica Section D 60, 2126-2132). During refinement, the geometry of the protein was checked using Molprobity (Davis, I. W., et al. (2007) Nucl. Acids Res., gkm216).
The fold of P. tremuloides IspS is similar to bornyl diphosphate synthase (Whittington, D. A., et al. (2002) Proc. Natl. Acad. Sci. USA 99, 15375-15380), limonene synthase (Hyatt, D. C., et al. (2007) Proc. Natl. Acad. Sci. USA 104, 5360-5365), and tobacco 5-epi-aristolochene synthase (Starks, C. M., et al. (1997) Science 277, 1815-1820). The structure consists of two helical domains, a C-terminal domain containing the active site and N-terminal domain with unknown function (FIGS. 30 and 31). Coordinates are provided in Table 3-7.







TABLE 3-1





Data Collection and Refinement Statistics


















Data Collection




Space Group
P43212



Cell dimensions



A, b, c (Å)
154.2, 154.2, 142.7



α, β, γ, (°)
90.0, 90.0, 90.0



Resolution (Å)
37.8-3.05



Rmerge
  16.4 (72.9)a



<I/σI>
10.3 (2.6) 



Completeness (%)
99.8 (100) 



Redundancy
7.3 (7.4)



Refinement



Resolution (Å)
37.8-3.05



No. measured reflections
248741



No. Unique reflections
34201



Rwork
21.1



Rfree
27.1



rmsd bonds, (Å)
0.011



rmsd angles, (°)
1.28



No. of Atoms



Protein, ionsb
8331



Water
18










Flexible Loops

The unique and unexpected discovery coming from the determination of the three-dimensional structure of isoprene synthase is that several crucial loops forming the active site are flexible. The discovery can be immediately seen when the known structure of other terpene synthases are compared with the structure of isoprene synthase (FIG. 32). Overall, the structures are highly conserved in the conformation of secondary structure and connectivity loops. (In this example of the P. tremuloides IspS from construct P.tremTRC-pET200, the numbering convention is such that the first number of the complete sequence containing the tag is −35, with the first residue of IspS being 1.) However, three segments, forming a considerable portion of the substrate binding pocket, notably the truncated N-terminus, along with two loops comprised of residues 438-453 (Loop I) and residues 512-527 (Loop II) are seen to diverge (FIGS. 33 to 36). This has been attributed to the absence of substrate complexed with the enzyme in our structure determination.
In comparing the enzyme with BdpS, for example, we find that the loops corresponding to residues 498-513 and 573-587 are composed of the same number of residues and have a homologous, but not identical amino sequence in these regions. We expect that the related terpene synthases will be found to display similar flexibility in the segments as these structures become more thoroughly studied. The residues in terpene synthases corresponding to these variable loop regions are enumerated in Table 3-2.







TABLE 3-2







Residues corresponding to variable loops in terpene synthases.












P. tremuloides






IspS
LS
BdpS
TEAS

















N-term I
Met 1
Met 57
Ile 54
Val 14




Arg 2
Arg 58
Arg 55
Arg 15




Arg 3
Arg 59
Arg 56
Pro 16




Ser 4
Ser 60
Ser 57
Val 17




Ala 5
Gly 61
Gly 58
Ala 18




Asn 6
Asn 62
Asn 59
Asp 19




Tyr 7
Tyr 63
Tyr 60
Phe 20




Glu 8
Asn 64
Gln 61
Ser 21




Pro 9
Pro 65
Pro 62
Pro 22




Asn 10
Ser 66
Ala 63
Ser 23




Ser 11
Arg 67
Leu 64
Leu 24




Trp 12
Trp 68
Trp 65
Trp 25




Asp 13
Asp 69
Asp 66
Gly 26




Tyr 14
Val 70
Ser 67
Asp 27




Asp 15
Asn 71
Asn 68
Gln 28




Tyr 16
Phe 72
Tyr 69
Phe 29



N-term II
Leu 17
Ile 73
Ile 70
Leu 30




Leu 18
Gln 74
Gln 71
Ser 31




Ser 19
Ser 75
Ser 72
Phe 32




Ser 20
Leu 76
Leu 73
Ser 34




Asp 21
Leu 77
Asn 74
Ile 35




Thr 22
Ser 78
Thr 75
Asp 36




Asp 23
Asp 79
Pro 76
Asn 37




Glu 24
Tyr 80
Tyr 77
Gln 38




Ser 25
Lys 81
Thr 78
Val 39




Ile 26
Glu 82
Glu 79
Ala 40




Glu 27
Asp 83
Glu 80
Glu 41




Val 28
Lys 84
Arg 81
Lys 42



Loop I
Leu 438
Leu 498
Leu 498
Thr 446




Ala 439
Gly 499
Gly 499
Ala 447




Ser 440
Thr 500
Thr 500
The 448




Ala 441
Ser 501
Ser 502
Tyr 449




Ser 442
Val 502
Tyr 503
Glu 450




Ala 443
Glu 503
Phe 504
Val 451




Glu 444
Glu 504
Glu 505
Glu 452




Ile 445
Val 505
Leu 506
Lys 453




Ala 446
Ser 506
Ala 507
Ser 454




Arg 447
Arg 507
Arg 508
Arg 455




Gly 448
Gly 508
Gly 509
Gly 456




Glu 449
Asp 509
Asp 510
Gln 457




Thr 450
Val 510
Val 511
Ile 458




Ala 451
Pro 511
Pro 512
Ala 459




Asn 452
Lys 512
Lys 513
Thr 460




Ser 453
Ser 513
Thr 514
Gly 461



Loop II
Tyr 512
Tyr 576
Tyr 573
Tyr 520







Ile 521




His 513
His 577
Leu 574
His 522




Asn 514
Asn 578
His 575
Asn 523




Gly 515
Gly 579
Gly 576
Leu 524




Asp 516
Asp 580
Asp 577
Asp 525




Ala 517
Gly 581
Gly 578
Gly 526




His 518
His 582
Phe 579
Tyr 527




Thr 519
Gly 583
Gly 580
The 528




Ser 520
Thr 584
Val 581
His 529




Pro 521
Gln 585
Gln 582
Pro 530




Asp 522
His 585
His 583
Glu 531




Glu 523
Pro 586
Ser 584
Lys 532




Leu 524
Ile 587
Lys 585
Val 533




Thr 525
Ile 588
Thr 586
Lue 534




Arg 526
His 589
Tyr 587
Lys 535










This important finding can be exploited for the engineering of improved isoprene synthase in a straightforward manner. It would be desirable to exploit the flexibility to enhance enzyme performance by making substitutions in the amino aids forming these segments to facilitate the transitions the enzyme must undergo in the steps of binding substrate and allowing rearrangement of substrate in different kinetic steps that are postulated to occur during enzymatic de-phosphorylation and for electron transfer to convert DMAPP to isoprene.
The structure provides the new insight that these loops can be present in at least two conformations: the “open” form in the absence of substrate, as we have see in the uncomplexed structure of the isoprene synthase, and a “closed,” or active form when the substrate is bound. It would therefore also be beneficial to modify residues coming in contact with the loops in the active form as described in Table 3-3.







TABLE 3-3







Residues coming within 5 angstroms of flexible elements












P trem IspS
1N1B
2ONG
5EASe















N-term
L17, L18, S19, S20,
70I, 71Q, 72S, 73L,
I73, Q74, S75, L76,
L30, S31, F32, S33,


neighbors
S239, R243, F253,
298S, 302S, 312F,
F299, R303, F313,
S248, K252, Y262,



A254, R255, D256,
313V, 314R, 315D,
A314, R315, A316,
A263, R264, D265,



R257, I259, E260,
316R, 318V, 319E,
R317, V319, E320,
R266, V268, E269,



D293, Y295, D296,
352D, 354Y, 355D,
D353, Y355, D356,
D302, F304, D305,



V297, Y298, G299,
356V, 357Y, 358G,
V357, Y358, G359,
A306, Y307, G308,



T300, E303, Y325,
359T, 362E, 384Y,
T360, E363, Y385,
T309, E312, Y334,



L374, Y375, elements
433Y, 434H, elements
F434, Y435, elements
F383, I384, elements of



of loop I, elements of
of loop I, elements of
of loop I, elements of
loop I, elements of loop



loop II, V529, L530,
loop II, 589I, 590A,
loop II, M590, T591,
II, I538, I538, V543



T534
594F
F595


Loop I
Elements of N-term,
Elements of N-term,
Elements of N-term,
Elements of N-term,


neighbors
D293, Y295, V297,
352D, 354Y, 356V,
D353, Y355, V357,
D304, F304, A306,



E370, A371, W373,
429E, 430A, 432W,
E430, A431, W433,
E379, S380, W382,



L374, S378, T379,
433Y, 437Y, 438T,
F434, H438, K439,
F383, Y387, T388,



P380, F382, Y385,
439P, 441L, 444Y,
P440, L442, Y445,
P389, V391, Y394,



F386, R433, L434
445L, 493R, 494L,
L446, R493, L494,
L395, R441, V442,



C435, N436, D437,
495P, 496D, 497D,
A495, D496, D497,
I443, D444, D445,



V454, S455, C456,
514I, 515Q, 516C,
L514, Q515, C516,
I462, E463, C464,



Y457, M458, T469,
517Y, 518M, 529V,
Y517, M518, R529,
C465, M466, M477,



V472, I476, Y512,
532V, 536I, 572Y,
V532, I536, Y573,
F480, A484, Y520,



elements of loop II
elements of loop II
elements of loop II
elements of loop II


Loop II
Elements of N-
Elements of N-
Elements of N-
Elements of N-


neighbors
terminus, E187, L188,
terminus, 246D, 247L,
terminus, D247, I248,
terminus, E195, Q196,



R255, R257, F270,
314R, 316R, 329E,
R315, R317, E330,
R264, R266, F279,



E271, Q273, Y274,
330S, 332F, 333W,
P331, Q333, H334,
E280, Q282, Y283,



F285, V288, A439,
344I, 348I, 499G,
N345, I347, G499,
I294, I297, A447,



S440, S442, S508,
500T, 503Y, 568A,
T500, V502, A569,
T448, E450, V516,



H509, C510, T511,
569Q, 570F, 571I,
Q570, L571, M572,
E517, V518, T519,



Y512, R528, V529,
572Y, 588H, 589I,
Y573, Q589, M590,
Y520, H537, I538,



L530, S531, V532
590A, 591G, 592L
T591, R592, T593
I539, N540, L541









Selection of Sites for Improvement of Plant Isoprene Synthase

The isoprene synthases of plants were expected to be homologous to the terpene synthases. The three-dimensional structures of three homologous terpene synthases have been determined: Salvia officinalis bornyl diphosphate synthase (BdpS; pdb entry 1N1B), Mentha spicata limonene synthase (LS; pdb entry 2ONG), and tobacco 5-epi-aristolochene synthase (TEAS; pdb entry SEAS). These enzymes share only 33% homology but their tertiary structure is conserved. Sequence identity is shown in Table 3-4, and structural homology between the structures is shown in Table 3-5. In addition, the structures of intermediate complexes with all three related enzymes have shown that not only tertiary folding, but also detailed interactions in the active sites of these enzymes are highly conserved.







TABLE 3-4







Percent Identity of Terpene Cyclases.














P trem IspS
1N1B
2ONG
5EASe

















P alba IspSa
98.6
40.7
41.3
33.2



P trem IspSb

41.0
41.4
33.2



1N1Bc


51.4
33.8



2ONGd



33.3







aPolar alba isoprene synthase



bPolar tremuloides isoprene synthase



cbornyl diphosphate synthase



dlimonene synthase



e5-epi-aristolochene synthase













TABLE 3-5







Structural Alignment of Terpene Synthases.











1N1Bb
2ONGc
5EASd
















P trem IspSa
1.40 (465)e
1.29 (468)
1.62 (458)



1N1B

1.27 (520)
1.97 (476)



2ONG


1.83 (477)







aPolar tremuloides isoprene synthase



bbornyl diphosphate synthase



climonene synthase



d5-epi-aristolochene synthase



eRoot mean square deviation in Å for Cα atoms, with the number of aligned residues in parenthesis






In this example of the P. tremuloides IspS from construct P.tremTRC-pET200, the numbering convention is such that the first number of the complete sequence containing the tag is −35, with the first residue of IspS being 1.
A comparison of the active site from the structure of BdpS and the structure of IspS indicates that the active site involved in metal ion binding and phosphate recognition is conserved. In particular, Arg 255, Asp 292, Asp 296, Glu 370, Arg 433 and Asn 436 of P. tremuloides IspS were observed to overlap equivalent residues in BdpS. The positioning of an intermediate of the BdpS was also compared with the IspS structure. Based on this it was possible to identify the analogous binding region and the approach direction that dimethylallyl pyrophosphate would require in order to bind and react with the IspS enzyme.
Based on the structure of IspS, sites in the IspS were identified as candidates for mutagenesis to produce variant IspS enzymes with improved performance. Briefly, sites were selected in the IspS that might alter the interaction of the metal binding, diphosphate recognition, DMAPP chain binding and/or the approach to the active site.
I. Diphosphate/Metal Binding Sites
The side chains of amino acid residues in the IspS that are found in proximity to the metal and diphosphate binding side chains were identified. These residues include Asp 293, Tyr 385, Ser 392, and Asp 437 of P. tremuloides IspS. Engineering of these sites may result in increased enzyme activity.
II. Substrate Access Loops
The substrate access loops of IspS are in regions that deviate from the BdpS structure. In the BdpS structure the residues create a cover over the active site. It is likely that upon substrate binding the structure of IspS will form a similar structure. As such the residues in these loops, including residues 440-453 and 512-524, may be in a position to alter the activity of the IspS. In the P. tremuloides IspS enzyme, residues 440-453 have the sequence SASAEIARGETANS (SEQ ID NO:40) and residues 512-526 have the sequence YHNGDAHTSPDEL (SEQ ID NO:41).
III. Isoprenyl Binding Site
The complex of BdpS and the product of the reaction, bornyl diphosphate (PDB entry 1N24), was used to identify residues in the IspS structure that with protein engineering may be used modulate substrate specificity and/or reaction rate (altered on and off rates of substrate and product). These residues include Ser 261, Trp 264, Phe 285, Thr 289, Ser 393, Ser 394, Phe 432, and Try 512 P. tremuloides IspS.







TABLE 3-6







Candidate Mutagenesis Sites









P. tremuloides



IspS














DPP/Metal Binding Sites
Asp 293




Tyr 385




Ser 392




Asp 437



Substrate Access Loop I
Ser 440




Ala 441




Ser 442




Ala 443




Glu 444




Ile 445




Ala 446




Arg 447




Gly 448




Glu 449




Thr 450




Ala 451




Asn 452




Ser 453



Substate Access Loop II
Tyr 512




His 513




Asn 514




Gly 515




Asp 516




Ala 517




His 518




Thr 519




Ser 520




Pro 521




Asp 522




Glu 523




Leu 524



Isoprenyl Binding Site
Ser 261




Trp 264




Phe 285




Thr 289




Ser 393




Ser 394




Phe 432




Tyr 512

















TABLE 3-7





Coordinates of P. tremuloides IspS
















HEADER
--- XX-XXX-XX xxxx


COMPND
—


REMARK
3









REMARK
3
REFINEMENT.


REMARK
3
 PROGRAM : REFMAC 5.5.0088


REMARK
3
AUTHORS : MURSHUDOV, VAGIN, DODSON


REMARK
3


REMARK
3
 REFINEMENT TARGET: MAXIMUM LIKELIHOOD


REMARK
3


REMARK
3
DATA USED IN REFINEMENT.


REMARK
3
RESOLUTION RANGE HIGH (ANGSTROMS): 3.05


REMARK
3
RESOLUTION RANGE LOW (ANGSTROMS): 110.17


REMARK
3
DATA CUTOFF (SIGMA(F)): NONE


REMARK
3
COMPLETENESS FOR RANGE (%): 99.67


REMARK
3
NUMBER OF REFLECTIONS : 32446


REMARK
3


REMARK
3
FIT TO DATA USED IN REFINEMENT.


REMARK
3
CROSS-VALIDATION METHOD: THROUGHOUT


REMARK
3
FREE R VALUE TEST SET SELECTION: RANDOM


REMARK
3
R VALUE (WORKING + TEST SET): .21396


REMARK
3
R VALUE (WORKING SET) : .21092


REMARK
3
FREE R VALUE: .27112


REMARK
3
FREE R VALUE TEST SET SIZE (%): 5.1


REMARK
3
FREE R VALUE TEST SET COUNT : 1727


REMARK
3


REMARK
3
FIT IN THE HIGHEST RESOLUTION BIN.


REMARK
3
TOTAL NUMBER OF BINS USED : 20


REMARK
3
BIN RESOLUTION RANGE HIGH : 3.050


REMARK
3
BIN RESOLUTION RANGE LOW : 3.129


REMARK
3
REFLECTION IN BIN (WORKING SET): 2359


REMARK
3
BIN COMPLETENESS (WORKING + TEST) (%): 100.00


REMARK
3
BIN R VALUE (WORKING SET): .288


REMARK
3
BIN FREE R VALUE SET COUNT : 127


REMARK
3
BIN FREE R VALUE : .352


REMARK
3


REMARK
3
NUMBER OF NON-HYDROGEN ATOMS USED IN




REFINEMENT.


REMARK
3
ALL ATOMS : 8349


REMARK
3


REMARK
3
B VALUES.


REMARK
3
FROM WILSON PLOT (A**2): NULL


REMARK
3
MEAN B VALUE (OVERALL, A**2): 24.592


REMARK
3
OVERALL ANISOTROPIC B VALUE.


REMARK
3
 B11 (A**2): .41


REMARK
3
 B22 (A**2): .41


REMARK
3
 B33 (A**2): −.81


REMARK
3
 B12 (A**2): .00


REMARK
3
 B13 (A**2): .00


REMARK
3
 B23 (A**2): .00


REMARK
3


REMARK
3
ESTIMATED OVERALL COORDINATE ERROR.


REMARK
3
ESU BASED ON R VALUE (A): NULL


REMARK
3
ESU BASED ON FREE R VALUE (A): .427


REMARK
3
ESU BASED ON MAXIMUM LIKELIHOOD (A): .327


REMARK
3
ESU FOR B VALUES BASED ON MAXIMUM




LIKELIHOOD (A**2): 39.836


REMARK
3


REMARK
3
CORRELATION COEFFICIENTS.


REMARK
3
CORRELATION COEFFICIENT FO-FC : .916


REMARK
3
CORRELATION COEFFICIENT FO-FC FREE : .868


REMARK
3


REMARK
3
RMS DEVIATIONS FROM IDEAL VALUES COUNT RMS WEIGHT


REMARK
3
BOND LENGTHS REFINED ATOMS (A): 8495; .011;.022


REMARK
3
BOND LENGTHS OTHERS (A): 5804; .001; .020


REMARK
3
BOND ANGLES REFINED ATOMS (DEGREES): 11476; 1.279; 1.953


REMARK
3
BOND ANGLES OTHERS (DEGREES): 14093; .882; 3.000


REMARK
3
TORSION ANGLES, PERIOD 1 (DEGREES): 1020; 7.002; 5.000


REMARK
3
TORSION ANGLES, PERIOD 2 (DEGREES): 435; 35.412; 24.299


REMARK
3
TORSION ANGLES, PERIOD 3 (DEGREES): 1525; 18.250; 15.000


REMARK
3
TORSION ANGLES, PERIOD 4 (DEGREES): 58; 16.811; 15.000


REMARK
3
CHIRAL-CENTER RESTRAINTS (A**3): 1266; .070; .200


REMARK
3
GENERAL PLANES REFINED ATOMS (A): 9416; .005; .020


REMARK
3
GENERAL PLANES OTHERS (A): 1780; .001; .020


REMARK
3


REMARK
3
ISOTROPIC THERMAL FACTOR RESTRAINTS. COUNT RMS WEIGHT


REMARK
3
MAIN-CHAIN BOND REFINED ATOMS (A**2): 5104; .514; 1.500


REMARK
3
MAIN-CHAIN BOND OTHER ATOMS (A**2): 2068; .059; 1.500


REMARK
3
MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 8204; 1.000; 2.000


REMARK
3
SIDE-CHAIN BOND REFINED ATOMS (A**2): 3391; 1.218; 3.000


REMARK
3
SIDE-CHAIN ANGLE REFINED ATOMS (A**2): 3272; 2.157; 4.500


REMARK
3


REMARK
3
NCS RESTRAINTS STATISTICS


REMARK
3
NUMBER OF DIFFERENT NCS GROUPS: 1


REMARK
3


REMARK
3
NCS GROUP NUMBER : 1


REMARK
3
 CHAIN NAMES: A B


REMARK
3
 NUMBER OF COMPONENTS NCS GROUP: 1


REMARK
3
 COMPONENT C SSSEQI TO C SSSEQI CODE


REMARK
3
 1 A 17 A 541 6


REMARK
3
 1 B 17 B 541 6


REMARK
3
 GROUP CHAIN COUNT RMS WEIGHT


REMARK
3
LOOSE POSITIONAL 1 1 (A): 7038; .37; 5.00


REMARK
3
LOOSE THERMAL 1 1 (A**2): 7038; 1.09; 10.00


REMARK
3


REMARK
3
TWIN DETAILS


REMARK
3
NUMBER OF TWIN DOMAINS: NULL


REMARK
3


REMARK
3


REMARK
3
TLS DETAILS


REMARK
3
NUMBER OF TLS GROUPS : 8


REMARK
3
ATOM RECORD CONTAINS RESIDUAL B FACTORS




ONLY


REMARK
3


REMARK
3
TLS GROUP: 1


REMARK
3
 NUMBER OF COMPONENTS GROUP: 1


REMARK
3
 COMPONENTS C SSSEQI TO C SSSEQI


REMARK
3
 RESIDUE RANGE: A 17 A 219


REMARK
3
 ORIGIN FOR THE GROUP (A): −64.7667 37.6643 −.0896


REMARK
3
 T TENSOR


REMARK
3
 T11: .0648 T22: .0357


REMARK
3
 T33: .0787 T12: .0200


REMARK
3
 T13: .0129 T23: −.0089


REMARK
3
 L TENSOR


REMARK
3
 L11: 3.7204 L22: 1.5111


REMARK
3
 L33: 2.6701 L12: .5715


REMARK
3
 L13:  .6692 L23: −.9699


REMARK
3
 S TENSOR


REMARK
3
 S11: .0562 S12: .0478 S13: −.1976


REMARK
3
 S21: −.1702 S22: −.0055 S23: .1376


REMARK
3
 S31: .0900 S32: −.2188 S33: −.0507


REMARK
3


REMARK
3
TLS GROUP: 2


REMARK
3
 NUMBER OF COMPONENTS GROUP: 1


REMARK
3
 COMPONENTS C SSSEQI TO C SSSEQI


REMARK
3
 RESIDUE RANGE: A 220 A 287


REMARK
3
 ORIGIN FOR THE GROUP (A): −59.5787 8.4529 −.7693


REMARK
3
 T TENSOR


REMARK
3
 T11: .1615 T22: .0645


REMARK
3
 T33: .1539 T12: −.0314


REMARK
3
 T13: −.0461 T23: .0198


REMARK
3
 L TENSOR


REMARK
3
 L11: 2.4192 L22: 4.6709


REMARK
3
 L33: .7709 L12: −3.2943


REMARK
3
 L13: −.1814 L23: −.0705


REMARK
3
 S TENSOR


REMARK
3
 S11: .0055 S12: −.0699 S13: −.2073


REMARK
3
 S21: −.1805 S22: .0996 S23: .3781


REMARK
3
 S31: .2596 S32: .0887 S33: −.1051


REMARK
3


REMARK
3
TLS GROUP: 3


REMARK
3
 NUMBER OF COMPONENTS GROUP: 1


REMARK
3
 COMPONENTS C SSSEQI TO C SSSEQI


REMARK
3
 RESIDUE RANGE: A 288 A 374


REMARK
3
 ORIGIN FOR THE GROUP (A): −40.1866 1.6932 .5805


REMARK
3
 T TENSOR


REMARK
3
 T11: .1149 T22: .1003


REMARK
3
 T33: .1629 T12: .0153


REMARK
3
 T13: .0224 T23: .0164


REMARK
3
 L TENSOR


REMARK
3
 L11: .2271 L22: .7399


REMARK
3
 L33: 4.8529 L12: .3413


REMARK
3
 L13: .4755 L23: −.1746


REMARK
3
 S TENSOR


REMARK
3
 S11: −.0449 S12: −.0288 S13: −.1131


REMARK
3
 S21: −.1346 S22: −.0665 S23: −.2749


REMARK
3
 S31: −.0040 S32: .1558 S33: 1114


REMARK
3


REMARK
3
TLS GROUP: 4


REMARK
3
 NUMBER OF COMPONENTS GROUP: 1


REMARK
3
 COMPONENTS C SSSEQI TO C SSSEQI


REMARK
3
 RESIDUE RANGE: A 375 A 541


REMARK
3
 ORIGIN FOR THE GROUP (A): −47.2220 21.5399 6.9217


REMARK
3
 T TENSOR


REMARK
3
 T11: .1551 T22: .1194


REMARK
3
 T33: .1485 T12: −.0666


REMARK
3
 T13: .0275 T23: .0272


REMARK
3
 L TENSOR


REMARK
3
 L11: 2.2352 L22: 2.1698


REMARK
3
 L33: 2.3370 L12: −.4501


REMARK
3
 L13: 2.2662 L23: −.1852


REMARK
3
 S TENSOR


REMARK
3
 S11: .0233 S12: −.3041 S13: −.0323


REMARK
3
 S21: .3375 S22: .0236 S23: .0121


REMARK
3
 S31: .0592 S32: −.2979 S33: −.0469


REMARK
3


REMARK
3
TLS GROUP: 5


REMARK
3
 NUMBER OF COMPONENTS GROUP: 1


REMARK
3
 COMPONENTS C SSSEQI TO C SSSEQI


REMARK
3
 RESIDUE RANGE: B 17 B 219


REMARK
3
 ORIGIN FOR THE GROUP (A): −73.9834 −39.9016 −18.5783


REMARK
3
 T TENSOR


REMARK
3
 T11: .0658 T22: .1153


REMARK
3
 T33: .1251 T12: −.0621


REMARK
3
 T13: −.0164 T23: −.0098


REMARK
3
 L TENSOR


REMARK
3
 L11: 4.6230 L22: 1.7260


REMARK
3
 L33: 3.8816 L12: −.4202


REMARK
3
 L13: −1.8646 L23: −.9046


REMARK
3
 S TENSOR


REMARK
3
 S11: −.0685 S12: .0375 S13: −.0003


REMARK
3
 S21: .1931 S22: .0510 S23: −.0097


REMARK
3
 S31: .0317 S32: −.2047 S33: .0175


REMARK
3


REMARK
3
TLS GROUP: 6


REMARK
3
 NUMBER OF COMPONENTS GROUP: 1


REMARK
3
 COMPONENTS C SSSEQI TO C SSSEQI


REMARK
3
 RESIDUE RANGE: B 220 B 287


REMARK
3
 ORIGIN FOR THE GROUP (A): −62.1586 −12.7634 −18.1912


REMARK
3
 T TENSOR


REMARK
3
 T11: .1825 T22: .0804


REMARK
3
 T33: .1512 T12: .0549


REMARK
3
 T13: .0773 T23: .0208


REMARK
3
 L TENSOR


REMARK
3
 L11: 5.4421 L22: 4.0606


REMARK
3
 L33: 1.5369 L12: 4.6706


REMARK
3
 L13: −2.0058 L23: −1.5537


REMARK
3
 S TENSOR


REMARK
3
 S11: .1622 S12: .0431 S13: .3257


REMARK
3
 S21: .1755 S22: .0292 S23: .2977


REMARK
3
 S31: −.1910 S32: −.0506 S33: −.1914


REMARK
3


REMARK
3
TLS GROUP: 7


REMARK
3
 NUMBER OF COMPONENTS GROUP: 1


REMARK
3
 COMPONENTS C SSSEQI TO C SSSEQI


REMARK
3
 RESIDUE RANGE: B 288 B 374


REMARK
3
 ORIGIN FOR THE GROUP (A): −41.6930 −10.8250 −19.6636


REMARK
3
 T TENSOR


REMARK
3
 T11: .1424 T22: .0604


REMARK
3
 T33: .1153 T12: .0184


REMARK
3
 T13: .0146 T23: .0276


REMARK
3
 L TENSOR


REMARK
3
 L11: .6426 L22: .8163


REMARK
3
 L33: 2.3437 L12: −.1831


REMARK
3
 L13: −.5246 L23: .4917


REMARK
3
 S TENSOR


REMARK
3
 S11: .0592 S12: −.0206 S13: .0071


REMARK
3
 S21: .0906 S22: −.0229 S23: −.1585


REMARK
3
 S31: −.0355 S32 .0262 S33: −.0363


REMARK
3


REMARK
3
TLS GROUP: 8


REMARK
3
 NUMBER OF COMPONENTS GROUP: 1


REMARK
3
 COMPONENTS C SSSEQI TO C SSSEQI


REMARK
3
 RESIDUE RANGE: B 375 B 541


REMARK
3
 ORIGIN FOR THE GROUP (A): −53.4886 −28.3212 −26.0670


REMARK
3
 T TENSOR


REMARK
3
 T11:.1107 T22: .1220


REMARK
3
 T33: .1514 T12 .0692


REMARK
3
 T13: −.0073 T23: .0518


REMARK
3
 L TENSOR


REMARK
3
 L11: 2.6766 L22: 1.8433


REMARK
3
 L33: 2.6389 L12: .1130


REMARK
3
 L13: −2.4696 L23: .6986


REMARK
3
 S TENSOR


REMARK
3
 S11: .1115 S12: .3882 S13: .0569


REMARK
3
 S21: −.0725 S22: −.0724 S23: .1450


REMARK
3
 S31: −.1453 S32: −.4044 S33: −.0392


REMARK
3


REMARK
3


REMARK
3
BULK SOLVENT MODELLING.


REMARK
3
METHOD USED: MASK


REMARK
3
PARAMETERS FOR MASK CALCULATION


REMARK
3
VDW PROBE RADIUS: 1.40


REMARK
3
ION PROBE RADIUS: .80


REMARK
3
SHRINKAGE RADIUS: .80


REMARK
3


REMARK
3
OTHER REFINEMENT REMARKS:


REMARK
3
HYDROGENS HAVE BEEN ADDED IN THE RIDING




POSITIONS


REMARK
3
U VALUES: RESIDUAL ONLY


REMARK
3







CISPEP 1 ALA A 446 ARG A 447 .00


CISPEP 2 GLY A 515 ASP A 516 .00


CISPEP 3 THR B 22 ASP B 23 .00


CISPEP 4 ALA B 446 ARG B 447 .00


CISPEP 5 GLY B 515 ASP B 516 .00


CRYST1 155.800 155.800 143.690 90.00 90.00 90.00 P 43 21 2


SCALE1 .006418 .000000 .000000 .00000


SCALE2 .000000 .006418 .000000 .00000


SCALE3 .000000 .000000 .006959 .00000


















ATOM
1
N
LEU
A
17
−63.930
24.416
−19.202
1.00
30.90
N


ATOM
2
CA
LEU
A
17
−64.132
23.019
−19.731
1.00
31.43
C


ATOM
4
CB
LEU
A
17
−63.308
22.800
−21.021
1.00
31.35
C


ATOM
7
CG
LEU
A
17
−64.002
23.016
−22.386
1.00
31.95
C


ATOM
9
CD1
LEU
A
17
−62.989
23.068
−23.550
1.00
31.88
C


ATOM
13
CD2
LEU
A
17
−65.052
21.915
−22.676
1.00
31.95
C


ATOM
17
C
LEU
A
17
−63.783
21.952
−18.660
1.00
31.39
C


ATOM
18
O
LEU
A
17
−63.142
22.291
−17.651
1.00
31.61
O


ATOM
22
N
LEU
A
18
−64.216
20.693
−18.877
1.00
31.11
N


ATOM
23
CA
LEU
A
18
−63.986
19.529
−17.957
1.00
30.78
C


ATOM
25
CB
LEU
A
18
−62.503
19.072
−17.935
1.00
30.97
C


ATOM
28
CG
LEU
A
18
−61.303
19.949
−17.496
1.00
31.10
C


ATOM
30
CD1
LEU
A
18
−61.406
20.430
−16.064
1.00
30.71
C


ATOM
34
CD2
LEU
A
18
−59.977
19.173
−17.703
1.00
31.87
C


ATOM
38
C
LEU
A
18
−64.531
19.665
−16.522
1.00
30.38
C


ATOM
39
O
LEU
A
18
−64.837
18.667
−15.883
1.00
29.86
O


ATOM
41
N
SER
A
19
−64.587
20.900
−16.023
1.00
30.45
N


ATOM
42
CA
SER
A
19
−65.335
21.276
−14.815
1.00
30.37
C


ATOM
44
CB
SER
A
19
−64.604
22.417
−14.026
1.00
30.02
C


ATOM
47
OG
SER
A
19
−64.881
23.741
−14.489
1.00
28.00
O


ATOM
49
C
SER
A
19
−66.784
21.654
−15.218
1.00
31.03
C


ATOM
50
O
SER
A
19
−67.666
21.711
−14.367
1.00
30.95
O


ATOM
52
N
SER
A
20
−67.023
21.880
−16.519
1.00
31.85
N


ATOM
53
CA
SER
A
20
−68.355
22.247
−17.051
1.00
32.37
C


ATOM
55
CB
SER
A
20
−68.291
22.507
−18.579
1.00
32.39
C


ATOM
58
OG
SER
A
20
−67.387
23.542
−18.931
1.00
31.77
O


ATOM
60
C
SER
A
20
−69.357
21.124
−16.744
1.00
33.04
C


ATOM
61
O
SER
A
20
−69.076
20.254
−15.922
1.00
33.08
O


ATOM
63
N
ASP
A
21
−70.522
21.136
−17.393
1.00
33.88
N


ATOM
64
CA
ASP
A
21
−71.512
20.069
−17.206
1.00
34.48
C


ATOM
66
CB
ASP
A
21
−72.907
20.655
−17.127
1.00
34.59
C


ATOM
69
CG
ASP
A
21
−73.022
21.661
−16.006
1.00
35.54
C


ATOM
70
OD1
ASP
A
21
−72.041
21.836
−15.251
1.00
35.31
O


ATOM
71
OD2
ASP
A
21
−74.082
22.289
−15.870
1.00
38.72
O


ATOM
72
C
ASP
A
21
−71.409
18.975
−18.260
1.00
34.94
C


ATOM
73
O
ASP
A
21
−72.134
18.947
−19.269
1.00
34.58
O


ATOM
75
N
THR
A
22
−70.457
18.086
−17.989
1.00
35.66
N


ATOM
76
CA
THR
A
22
−70.340
16.799
−18.657
1.00
36.27
C


ATOM
78
CB
THR
A
22
−68.895
16.576
−19.168
1.00
36.30
C


ATOM
80
OG1
THR
A
22
−67.968
17.278
−18.322
1.00
36.04
O


ATOM
82
CG2
THR
A
22
−68.755
17.088
−20.604
1.00
36.11
C


ATOM
86
C
THR
A
22
−70.792
15.714
−17.648
1.00
36.83
C


ATOM
87
O
THR
A
22
−69.968
15.022
−17.035
1.00
37.05
O


ATOM
89
N
ASP
A
23
−72.121
15.599
−17.494
1.00
37.27
N


ATOM
90
CA
ASP
A
23
−72.790
14.802
−16.441
1.00
37.25
C


ATOM
92
CB
ASP
A
23
−72.962
15.659
−15.167
1.00
37.17
C


ATOM
95
CG
ASP
A
23
−71.625
16.081
−14.549
1.00
37.74
C


ATOM
96
OD1
ASP
A
23
−70.714
15.241
−14.436
1.00
38.88
O


ATOM
97
OD2
ASP
A
23
−71.472
17.256
−14.164
1.00
38.91
O


ATOM
98
C
ASP
A
23
−74.172
14.351
−16.956
1.00
37.18
C


ATOM
99
O
ASP
A
23
−75.137
15.112
−16.846
1.00
37.10
O


ATOM
101
N
GLU
A
24
−74.280
13.134
−17.501
1.00
37.23
N


ATOM
102
CA
GLU
A
24
−75.406
12.815
−18.410
1.00
37.58
C


ATOM
104
CB
GLU
A
24
−74.941
13.007
−19.865
1.00
37.77
C


ATOM
107
CG
GLU
A
24
−74.424
14.417
−20.239
1.00
37.98
C


ATOM
110
CD
GLU
A
24
−74.121
14.556
−21.746
1.00
38.35
C


ATOM
111
OE1
GLU
A
24
−74.284
13.564
−22.503
1.00
38.12
O


ATOM
112
OE2
GLU
A
24
−73.721
15.661
−22.174
1.00
38.18
O


ATOM
113
C
GLU
A
24
−76.139
11.440
−18.323
1.00
37.79
C


ATOM
114
O
GLU
A
24
−77.323
11.397
−17.960
1.00
37.90
O


ATOM
116
N
SER
A
25
−75.462
10.345
−18.696
1.00
37.92
N


ATOM
117
CA
SER
A
25
−76.140
9.070
−19.048
1.00
38.09
C


ATOM
119
CB
SER
A
25
−75.167
8.076
−19.723
1.00
38.11
C


ATOM
122
OG
SER
A
25
−74.503
7.239
−18.787
1.00
38.02
O


ATOM
124
C
SER
A
25
−76.917
8.374
−17.907
1.00
38.42
C


ATOM
125
O
SER
A
25
−76.635
8.581
−16.724
1.00
38.15
O


ATOM
127
N
ILE
A
26
−77.861
7.511
−18.312
1.00
39.00
N


ATOM
128
CA
ILE
A
26
−78.993
7.042
−17.476
1.00
39.30
C


ATOM
130
CB
ILE
A
26
−78.594
5.965
−16.429
1.00
39.34
C


ATOM
132
CG1
ILE
A
26
−77.892
4.791
−17.120
1.00
39.37
C


ATOM
135
CD1
ILE
A
26
−77.766
3.531
−16.253
1.00
39.46
C


ATOM
139
CG2
ILE
A
26
−79.836
5.423
−15.714
1.00
39.29
C


ATOM
143
C
ILE
A
26
−79.716
8.260
−16.852
1.00
39.66
C


ATOM
144
O
ILE
A
26
−79.274
8.831
−15.838
1.00
39.49
O


ATOM
146
N
GLU
A
27
−80.837
8.623
−17.486
1.00
39.99
N


ATOM
147
CA
GLU
A
27
−81.450
9.965
−17.383
1.00
40.11
C


ATOM
149
CB
GLU
A
27
−82.395
10.183
−18.587
1.00
40.19
C


ATOM
152
CG
GLU
A
27
−81.632
10.311
−19.904
1.00
40.60
C


ATOM
155
CD
GLU
A
27
−82.528
10.434
−21.116
1.00
41.06
C


ATOM
156
OE1
GLU
A
27
−83.328
9.502
−21.367
1.00
41.10
O


ATOM
157
OE2
GLU
A
27
−82.409
11.458
−21.830
1.00
41.36
O


ATOM
158
C
GLU
A
27
−82.144
10.264
−16.042
1.00
40.02
C


ATOM
159
O
GLU
A
27
−81.977
9.518
−15.071
1.00
40.01
O


ATOM
161
N
VAL
A
28
−82.899
11.370
−16.005
1.00
39.84
N


ATOM
162
CA
VAL
A
28
−83.463
11.960
−14.779
1.00
39.65
C


ATOM
164
CB
VAL
A
28
−83.884
10.905
−13.694
1.00
39.78
C


ATOM
166
CG1
VAL
A
28
−84.472
11.596
−12.456
1.00
39.87
C


ATOM
170
CG2
VAL
A
28
−84.887
9.880
−14.274
1.00
39.49
C


ATOM
174
C
VAL
A
28
−82.469
12.980
−14.206
1.00
39.46
C


ATOM
175
O
VAL
A
28
−82.798
13.717
−13.270
1.00
39.38
O


ATOM
177
N
HIS
A
29
−81.264
13.025
−14.786
1.00
39.30
N


ATOM
178
CA
HIS
A
29
−80.236
14.006
−14.412
1.00
39.23
C


ATOM
180
CB
HIS
A
29
−78.866
13.344
−14.186
1.00
39.45
C


ATOM
183
CG
HIS
A
29
−78.910
12.139
−13.296
1.00
41.29
C


ATOM
184
ND1
HIS
A
29
−78.407
12.140
−12.007
1.00
42.51
N


ATOM
186
CE1
HIS
A
29
−78.585
10.942
−11.472
1.00
43.37
C


ATOM
188
NE2
HIS
A
29
−79.181
10.164
−12.365
1.00
43.18
N


ATOM
190
CD2
HIS
A
29
−79.393
10.888
−13.515
1.00
42.55
C


ATOM
192
C
HIS
A
29
−80.090
15.110
−15.464
1.00
38.60
C


ATOM
193
O
HIS
A
29
−79.049
15.774
−15.499
1.00
38.61
O


ATOM
195
N
LYS
A
30
−81.110
15.320
−16.311
1.00
37.87
N


ATOM
196
CA
LYS
A
30
−81.265
16.610
−17.001
1.00
37.22
C


ATOM
198
CB
LYS
A
30
−82.283
16.542
−18.140
1.00
37.09
C


ATOM
201
CG
LYS
A
30
−81.764
15.794
−19.360
1.00
37.00
C


ATOM
204
CD
LYS
A
30
−82.831
15.653
−20.457
1.00
36.89
C


ATOM
207
CE
LYS
A
30
−82.413
14.637
−21.531
1.00
36.48
C


ATOM
210
NZ
LYS
A
30
−83.422
14.458
−22.611
1.00
35.46
N


ATOM
214
C
LYS
A
30
−81.648
17.649
−15.938
1.00
36.88
C


ATOM
215
O
LYS
A
30
−82.516
18.499
−16.136
1.00
36.71
O


ATOM
217
N
ASP
A
31
−80.982
17.506
−14.788
1.00
36.58
N


ATOM
218
CA
ASP
A
31
−80.895
18.476
−13.720
1.00
36.18
C


ATOM
220
CB
ASP
A
31
−80.518
17.751
−12.396
1.00
36.20
C


ATOM
223
CG
ASP
A
31
−79.863
18.669
−11.342
1.00
36.65
C


ATOM
224
OD1
ASP
A
31
−80.055
19.901
−11.390
1.00
38.17
O


ATOM
225
OD2
ASP
A
31
−79.147
18.150
−10.449
1.00
35.46
O


ATOM
226
C
ASP
A
31
−79.811
19.426
−14.226
1.00
35.74
C


ATOM
227
O
ASP
A
31
−78.628
19.279
−13.918
1.00
35.44
O


ATOM
229
N
LYS
A
32
−80.220
20.343
−15.096
1.00
35.30
N


ATOM
230
CA
LYS
A
32
−79.360
21.449
−15.507
1.00
34.69
C


ATOM
232
CB
LYS
A
32
−78.698
21.188
−16.849
1.00
34.63
C


ATOM
235
CG
LYS
A
32
−77.699
20.042
−16.765
1.00
34.51
C


ATOM
238
CD
LYS
A
32
−76.953
19.853
−18.078
1.00
34.48
C


ATOM
241
CE
LYS
A
32
−76.859
18.387
−18.503
1.00
33.77
C


ATOM
244
NZ
LYS
A
32
−77.002
18.244
−19.985
1.00
32.92
N


ATOM
248
C
LYS
A
32
−80.162
22.745
−15.459
1.00
34.01
C


ATOM
249
O
LYS
A
32
−80.468
23.380
−16.473
1.00
33.41
O


ATOM
251
N
ALA
A
33
−80.540
23.051
−14.219
1.00
33.21
N


ATOM
252
CA
ALA
A
33
−80.785
24.381
−13.766
1.00
32.60
C


ATOM
254
CB
ALA
A
33
−81.619
24.347
−12.484
1.00
32.28
C


ATOM
258
C
ALA
A
33
−79.411
25.031
−13.524
1.00
32.31
C


ATOM
259
O
ALA
A
33
−79.335
26.081
−12.901
1.00
32.80
O


ATOM
261
N
LYS
A
34
−78.323
24.389
−13.968
1.00
31.70
N


ATOM
262
CA
LYS
A
34
−77.035
25.071
−14.186
1.00
31.12
C


ATOM
264
CB
LYS
A
34
−75.863
24.089
−14.128
1.00
31.23
C


ATOM
267
CG
LYS
A
34
−75.118
24.077
−12.791
1.00
31.76
C


ATOM
270
CD
LYS
A
34
−73.584
24.412
−12.921
1.00
31.49
C


ATOM
273
CE
LYS
A
34
−72.685
23.269
−12.506
1.00
30.50
C


ATOM
276
NZ
LYS
A
34
−72.951
22.090
−13.348
1.00
29.53
N


ATOM
280
C
LYS
A
34
−77.024
25.884
−15.518
1.00
30.50
C


ATOM
281
O
LYS
A
34
−76.977
25.353
−16.625
1.00
29.82
O


ATOM
283
N
LYS
A
35
−76.927
27.191
−15.337
1.00
29.97
N


ATOM
284
CA
LYS
A
35
−77.632
28.233
−16.098
1.00
29.41
C


ATOM
286
CB
LYS
A
35
−78.852
27.704
−16.867
1.00
29.53
C


ATOM
289
CG
LYS
A
35
−80.166
27.594
−16.077
1.00
30.18
C


ATOM
292
CD
LYS
A
35
−81.030
28.858
−16.203
1.00
31.25
C


ATOM
295
CE
LYS
A
35
−82.375
28.721
−15.486
1.00
31.85
C


ATOM
298
NZ
LYS
A
35
−83.298
29.865
−15.783
1.00
31.73
N


ATOM
302
C
LYS
A
35
−78.053
29.277
−15.026
1.00
28.53
C


ATOM
303
O
LYS
A
35
−78.246
30.460
−15.307
1.00
28.53
O


ATOM
305
N
LEU
A
36
−78.225
28.791
−13.796
1.00
27.29
N


ATOM
306
CA
LEU
A
36
−77.998
29.576
−12.594
1.00
26.21
C


ATOM
308
CB
LEU
A
36
−78.088
28.679
−11.364
1.00
25.76
C


ATOM
311
CG
LEU
A
36
−79.468
28.350
−10.832
1.00
24.08
C


ATOM
313
CD1
LEU
A
36
−79.376
27.233
−9.836
1.00
22.16
C


ATOM
317
CD2
LEU
A
36
−80.051
29.586
−10.213
1.00
23.45
C


ATOM
321
C
LEU
A
36
−76.587
30.137
−12.665
1.00
25.93
C


ATOM
322
O
LEU
A
36
−76.290
31.221
−12.137
1.00
26.11
O


ATOM
324
N
GLU
A
37
−75.714
29.332
−13.260
1.00
25.24
N


ATOM
325
CA
GLU
A
37
−74.381
29.739
−13.650
1.00
24.85
C


ATOM
327
CB
GLU
A
37
−73.678
28.566
−14.313
1.00
24.74
C


ATOM
330
CG
GLU
A
37
−72.182
28.667
−14.285
1.00
23.93
C


ATOM
333
CD
GLU
A
37
−71.519
27.490
−14.937
1.00
22.32
C


ATOM
334
OE1
GLU
A
37
−72.203
26.738
−15.657
1.00
20.57
O


ATOM
335
OE2
GLU
A
37
−70.303
27.322
−14.728
1.00
22.27
O


ATOM
336
C
GLU
A
37
−74.391
30.927
−14.600
1.00
24.69
C


ATOM
337
O
GLU
A
37
−73.666
31.891
−14.389
1.00
24.49
O


ATOM
339
N
ALA
A
38
−75.203
30.850
−15.650
1.00
24.68
N


ATOM
340
CA
ALA
A
38
−75.352
31.960
−16.599
1.00
24.87
C


ATOM
342
CB
ALA
A
38
−76.453
31.656
−17.609
1.00
24.53
C


ATOM
346
C
ALA
A
38
−75.643
33.278
−15.880
1.00
25.08
C


ATOM
347
O
ALA
A
38
−75.009
34.295
−16.135
1.00
25.21
O


ATOM
349
N
GLU
A
39
−76.591
33.228
−14.956
1.00
25.35
N


ATOM
350
CA
GLU
A
39
−77.050
34.400
−14.219
1.00
25.51
C


ATOM
352
CB
GLU
A
39
−78.283
34.014
−13.396
1.00
25.95
C


ATOM
355
CG
GLU
A
39
−79.302
35.119
−13.136
1.00
27.03
C


ATOM
358
CD
GLU
A
39
−80.715
34.557
−12.906
1.00
28.70
C


ATOM
359
OE1
GLU
A
39
−81.006
33.416
−13.346
1.00
27.40
O


ATOM
360
OE2
GLU
A
39
−81.540
35.266
−12.289
1.00
31.12
O


ATOM
361
C
GLU
A
39
−75.970
34.966
−13.306
1.00
25.11
C


ATOM
362
O
GLU
A
39
−75.870
36.167
−13.164
1.00
25.28
O


ATOM
364
N
VAL
A
40
−75.182
34.107
−12.672
1.00
24.86
N


ATOM
365
CA
VAL
A
40
−74.079
34.568
−11.824
1.00
24.69
C


ATOM
367
CB
VAL
A
40
−73.511
33.420
−10.952
1.00
24.56
C


ATOM
369
CG1
VAL
A
40
−72.239
33.857
−10.240
1.00
23.69
C


ATOM
373
CG2
VAL
A
40
−74.553
32.955
−9.955
1.00
24.68
C


ATOM
377
C
VAL
A
40
−72.971
35.148
−12.698
1.00
24.76
C


ATOM
378
O
VAL
A
40
−72.337
36.139
−12.362
1.00
24.16
O


ATOM
380
N
ARG
A
41
−72.744
34.506
−13.831
1.00
25.25
N


ATOM
381
CA
ARG
A
41
−71.727
34.948
−14.769
1.00
25.66
C


ATOM
383
CB
ARG
A
41
−71.576
33.927
−15.896
1.00
25.88
C


ATOM
386
CG
ARG
A
41
−70.726
34.385
−17.062
1.00
27.04
C


ATOM
389
CD
ARG
A
41
−71.519
35.178
−18.095
1.00
27.90
C


ATOM
392
NE
ARG
A
41
−70.653
35.635
−19.180
1.00
29.20
N


ATOM
394
CZ
ARG
A
41
−70.946
36.615
−20.034
1.00
29.94
C


ATOM
395
NH1
ARG
A
41
−70.077
36.945
−20.980
1.00
29.86
N


ATOM
398
NH2
ARG
A
41
−72.096
37.273
−19.957
1.00
30.54
N


ATOM
401
C
ARG
A
41
−72.104
36.301
−15.335
1.00
25.60
C


ATOM
402
O
ARG
A
41
−71.237
37.113
−15.612
1.00
25.77
O


ATOM
404
N
ARG
A
42
−73.400
36.521
−15.537
1.00
25.50
N


ATOM
405
CA
ARG
A
42
−73.900
37.810
−15.979
1.00
25.39
C


ATOM
407
CB
ARG
A
42
−75.389
37.723
−16.313
1.00
25.09
C


ATOM
410
CG
ARG
A
42
−76.077
39.062
−16.445
1.00
23.84
C


ATOM
413
CD
ARG
A
42
−77.459
38.906
−16.980
1.00
22.37
C


ATOM
416
NE
ARG
A
42
−78.448
38.554
−15.965
1.00
21.69
N


ATOM
418
CZ
ARG
A
42
−79.705
38.206
−16.248
1.00
22.99
C


ATOM
419
NH1
ARG
A
42
−80.122
38.146
−17.517
1.00
24.16
N


ATOM
422
NH2
ARG
A
42
−80.557
37.900
−15.275
1.00
22.94
N


ATOM
425
C
ARG
A
42
−73.666
38.889
−14.925
1.00
26.00
C


ATOM
426
O
ARG
A
42
−73.173
39.959
−15.244
1.00
26.17
O


ATOM
428
N
GLU
A
43
−74.014
38.621
−13.673
1.00
26.66
N


ATOM
429
CA
GLU
A
43
−73.930
39.662
−12.650
1.00
27.47
C


ATOM
431
CB
GLU
A
43
−74.749
39.304
−11.401
1.00
27.97
C


ATOM
434
CG
GLU
A
43
−76.274
39.266
−11.661
1.00
31.05
C


ATOM
437
CD
GLU
A
43
−76.869
40.636
−12.063
1.00
34.68
C


ATOM
438
OE1
GLU
A
43
−76.804
41.571
−11.222
1.00
37.63
O


ATOM
439
OE2
GLU
A
43
−77.398
40.773
−13.205
1.00
34.52
O


ATOM
440
C
GLU
A
43
−72.494
40.035
−12.275
1.00
27.15
C


ATOM
441
O
GLU
A
43
−72.292
41.118
−11.716
1.00
27.49
O


ATOM
443
N
ILE
A
44
−71.517
39.166
−12.588
1.00
26.57
N


ATOM
444
CA
ILE
A
44
−70.090
39.456
−12.334
1.00
25.80
C


ATOM
446
CB
ILE
A
44
−69.206
38.187
−12.187
1.00
25.52
C


ATOM
448
CG1
ILE
A
44
−69.624
37.320
−11.010
1.00
24.69
C


ATOM
451
CD1
ILE
A
44
−68.828
36.061
−10.899
1.00
23.08
C


ATOM
455
CG2
ILE
A
44
−67.790
38.581
−11.916
1.00
25.73
C


ATOM
459
C
ILE
A
44
−69.522
40.286
−13.472
1.00
25.40
C


ATOM
460
O
ILE
A
44
−68.745
41.211
−13.236
1.00
25.26
O


ATOM
462
N
ASN
A
45
−69.912
39.945
−14.700
1.00
25.14
N


ATOM
463
CA
ASN
A
45
−69.480
40.669
−15.906
1.00
25.02
C


ATOM
465
CB
ASN
A
45
−69.696
39.813
−17.151
1.00
24.69
C


ATOM
468
CG
ASN
A
45
−68.662
38.735
−17.302
1.00
24.01
C


ATOM
469
OD1
ASN
A
45
−67.470
39.013
−17.395
1.00
23.81
O


ATOM
470
ND2
ASN
A
45
−69.111
37.490
−17.344
1.00
23.28
N


ATOM
473
C
ASN
A
45
−70.177
42.014
−16.114
1.00
25.52
C


ATOM
474
O
ASN
A
45
−69.704
42.836
−16.890
1.00
25.40
O


ATOM
476
N
ASN
A
46
−71.308
42.210
−15.437
1.00
26.33
N


ATOM
477
CA
ASN
A
46
−72.085
43.453
−15.468
1.00
26.72
C


ATOM
479
CB
ASN
A
46
−73.102
43.404
−14.322
1.00
26.31
C


ATOM
482
CG
ASN
A
46
−73.935
44.641
−14.209
1.00
24.24
C


ATOM
483
OD1
ASN
A
46
−73.948
45.472
−15.091
1.00
22.38
O


ATOM
484
ND2
ASN
A
46
−74.645
44.766
−13.106
1.00
21.64
N


ATOM
487
C
ASN
A
46
−71.185
44.680
−15.349
1.00
28.11
C


ATOM
488
O
ASN
A
46
−70.603
44.933
−14.304
1.00
28.16
O


ATOM
490
N
GLU
A
47
−71.084
45.441
−16.433
1.00
29.93
N


ATOM
491
CA
GLU
A
47
−70.128
46.558
−16.544
1.00
31.30
C


ATOM
493
CB
GLU
A
47
−69.933
46.969
−18.013
1.00
31.28
C


ATOM
496
CG
GLU
A
47
−69.737
45.795
−19.020
1.00
32.37
C


ATOM
499
CD
GLU
A
47
−71.060
45.127
−19.545
1.00
32.69
C


ATOM
500
OE1
GLU
A
47
−72.055
45.833
−19.816
1.00
32.16
O


ATOM
501
OE2
GLU
A
47
−71.087
43.880
−19.699
1.00
32.41
O


ATOM
502
C
GLU
A
47
−70.582
47.774
−15.729
1.00
32.47
C


ATOM
503
O
GLU
A
47
−69.760
48.525
−15.230
1.00
32.86
O


ATOM
505
N
LYS
A
48
−71.898
47.945
−15.585
1.00
33.93
N


ATOM
506
CA
LYS
A
48
−72.491
49.075
−14.861
1.00
34.85
C


ATOM
508
CB
LYS
A
48
−73.660
49.672
−15.684
1.00
35.08
C


ATOM
511
CG
LYS
A
48
−73.221
50.119
−17.126
1.00
36.58
C


ATOM
514
CD
LYS
A
48
−74.035
51.277
−17.751
1.00
37.93
C


ATOM
517
CE
LYS
A
48
−75.353
50.799
−18.415
1.00
39.02
C


ATOM
520
NZ
LYS
A
48
−75.159
49.990
−19.669
1.00
39.11
N


ATOM
524
C
LYS
A
48
−72.926
48.632
−13.465
1.00
35.26
C


ATOM
525
O
LYS
A
48
−74.011
48.954
−13.015
1.00
35.04
O


ATOM
527
N
ALA
A
49
−72.051
47.890
−12.790
1.00
36.29
N


ATOM
528
CA
ALA
A
49
−72.321
47.348
−11.456
1.00
37.18
C


ATOM
530
CB
ALA
A
49
−71.828
45.923
−11.353
1.00
37.20
C


ATOM
534
C
ALA
A
49
−71.618
48.191
−10.418
1.00
37.88
C


ATOM
535
O
ALA
A
49
−70.480
48.610
−10.638
1.00
38.17
O


ATOM
537
N
GLU
A
50
−72.278
48.404
−9.280
1.00
38.53
N


ATOM
538
CA
GLU
A
50
−71.730
49.242
−8.213
1.00
39.08
C


ATOM
540
CB
GLU
A
50
−72.790
49.545
−7.146
1.00
39.43
C


ATOM
543
CG
GLU
A
50
−72.708
50.953
−6.600
1.00
40.86
C


ATOM
546
CD
GLU
A
50
−73.089
52.010
−7.639
1.00
42.77
C


ATOM
547
OE1
GLU
A
50
−74.225
52.530
−7.570
1.00
45.07
O


ATOM
548
OE2
GLU
A
50
−72.265
52.320
−8.530
1.00
43.35
O


ATOM
549
C
GLU
A
50
−70.560
48.521
−7.600
1.00
38.89
C


ATOM
550
O
GLU
A
50
−70.699
47.378
−7.201
1.00
39.05
O


ATOM
552
N
PHE
A
51
−69.411
49.181
−7.536
1.00
38.99
N


ATOM
553
CA
PHE
A
51
−68.161
48.502
−7.196
1.00
39.52
C


ATOM
555
CB
PHE
A
51
−67.000
49.494
−7.098
1.00
40.05
C


ATOM
558
CG
PHE
A
51
−66.460
49.948
−8.431
1.00
42.80
C


ATOM
559
CD1
PHE
A
51
−66.135
49.014
−9.435
1.00
45.21
C


ATOM
561
CE1
PHE
A
51
−65.612
49.425
−10.675
1.00
46.12
C


ATOM
563
CZ
PHE
A
51
−65.403
50.790
−10.917
1.00
47.21
C


ATOM
565
CE2
PHE
A
51
−65.726
51.741
−9.913
1.00
46.72
C


ATOM
567
CD2
PHE
A
51
−66.247
51.310
−8.679
1.00
45.05
C


ATOM
569
C
PHE
A
51
−68.223
47.687
−5.905
1.00
39.05
C


ATOM
570
O
PHE
A
51
−67.897
46.506
−5.900
1.00
39.28
O


ATOM
572
N
LEU
A
52
−68.648
48.307
−4.813
1.00
38.42
N


ATOM
573
CA
LEU
A
52
−68.709
47.610
−3.528
1.00
37.94
C


ATOM
575
CB
LEU
A
52
−69.084
48.594
−2.413
1.00
38.53
C


ATOM
578
CG
LEU
A
52
−68.057
49.726
−2.181
1.00
40.46
C


ATOM
580
CD1
LEU
A
52
−68.691
51.101
−1.787
1.00
41.88
C


ATOM
584
CD2
LEU
A
52
−67.020
49.274
−1.141
1.00
41.83
C


ATOM
588
C
LEU
A
52
−69.667
46.406
−3.532
1.00
36.72
C


ATOM
589
O
LEU
A
52
−69.517
45.494
−2.724
1.00
36.84
O


ATOM
591
N
THR
A
53
−70.649
46.398
−4.431
1.00
35.37
N


ATOM
592
CA
THR
A
53
−71.545
45.247
−4.569
1.00
34.11
C


ATOM
594
CB
THR
A
53
−72.867
45.594
−5.277
1.00
33.87
C


ATOM
596
OG1
THR
A
53
−73.339
46.863
−4.828
1.00
33.49
O


ATOM
598
CG2
THR
A
53
−73.917
44.535
−4.983
1.00
33.70
C


ATOM
602
C
THR
A
53
−70.853
44.148
−5.359
1.00
33.04
C


ATOM
603
O
THR
A
53
−70.893
42.977
−4.973
1.00
32.90
O


ATOM
605
N
LEU
A
54
−70.228
44.528
−6.467
1.00
31.76
N


ATOM
606
CA
LEU
A
54
−69.469
43.578
−7.286
1.00
31.13
C


ATOM
608
CB
LEU
A
54
−68.721
44.308
−8.392
1.00
30.92
C


ATOM
611
CG
LEU
A
54
−68.028
43.437
−9.424
1.00
30.27
C


ATOM
613
CD1
LEU
A
54
−69.034
42.769
−10.310
1.00
29.56
C


ATOM
617
CD2
LEU
A
54
−67.108
44.306
−10.242
1.00
31.15
C


ATOM
621
C
LEU
A
54
−68.466
42.808
−6.443
1.00
30.60
C


ATOM
622
O
LEU
A
54
−68.378
41.587
−6.543
1.00
30.30
O


ATOM
624
N
LEU
A
55
−67.725
43.551
−5.618
1.00
30.09
N


ATOM
625
CA
LEU
A
55
−66.730
43.000
−4.695
1.00
29.47
C


ATOM
627
CB
LEU
A
55
−66.006
44.126
−3.944
1.00
29.44
C


ATOM
630
CG
LEU
A
55
−65.069
45.017
−4.781
1.00
29.74
C


ATOM
632
CD1
LEU
A
55
−64.609
46.255
−4.003
1.00
29.43
C


ATOM
636
CD2
LEU
A
55
−63.859
44.234
−5.286
1.00
29.64
C


ATOM
640
C
LEU
A
55
−67.340
42.024
−3.696
1.00
28.87
C


ATOM
641
O
LEU
A
55
−66.746
40.991
−3.383
1.00
28.98
O


ATOM
643
N
GLU
A
56
−68.525
42.330
−3.198
1.00
28.01
N


ATOM
644
CA
GLU
A
56
−69.160
41.419
−2.256
1.00
27.64
C


ATOM
646
CB
GLU
A
56
−70.172
42.173
−1.395
1.00
28.19
C


ATOM
649
CG
GLU
A
56
−69.497
43.167
−.459
1.00
29.75
C


ATOM
652
CD
GLU
A
56
−70.457
43.858
.478
1.00
33.04
C


ATOM
653
OE1
GLU
A
56
−71.667
43.538
.481
1.00
34.46
O


ATOM
654
OE2
GLU
A
56
−69.988
44.737
1.226
1.00
36.78
O


ATOM
655
C
GLU
A
56
−69.776
40.200
−2.945
1.00
26.37
C


ATOM
656
O
GLU
A
56
−69.914
39.146
−2.333
1.00
26.02
O


ATOM
658
N
LEU
A
57
−70.134
40.347
−4.218
1.00
25.30
N


ATOM
659
CA
LEU
A
57
−70.569
39.212
−5.036
1.00
24.17
C


ATOM
661
CB
LEU
A
57
−71.125
39.680
−6.382
1.00
23.71
C


ATOM
664
CG
LEU
A
57
−71.417
38.568
−7.390
1.00
22.27
C


ATOM
666
CD1
LEU
A
57
−72.515
37.675
−6.858
1.00
19.31
C


ATOM
670
CD2
LEU
A
57
−71.752
39.167
−8.768
1.00
20.30
C


ATOM
674
C
LEU
A
57
−69.404
38.267
−5.284
1.00
23.69
C


ATOM
675
O
LEU
A
57
−69.547
37.051
−5.136
1.00
23.83
O


ATOM
677
N
ILE
A
58
−68.261
38.822
−5.682
1.00
22.82
N


ATOM
678
CA
ILE
A
58
−67.070
38.019
−5.925
1.00
22.39
C


ATOM
680
CB
ILE
A
58
−65.884
38.899
−6.355
1.00
22.21
C


ATOM
682
CG1
ILE
A
58
−66.088
39.386
−7.792
1.00
21.83
C


ATOM
685
CD1
ILE
A
58
−65.002
40.314
−8.320
1.00
20.43
C


ATOM
689
CG2
ILE
A
58
−64.565
38.131
−6.245
1.00
22.64
C


ATOM
693
C
ILE
A
58
−66.719
37.227
−4.662
1.00
22.35
C


ATOM
694
O
ILE
A
58
−66.520
36.002
−4.706
1.00
21.95
O


ATOM
696
N
ASP
A
59
−66.676
37.951
−3.543
1.00
22.32
N


ATOM
697
CA
ASP
A
59
−66.396
37.396
−2.215
1.00
22.26
C


ATOM
699
CB
ASP
A
59
−66.570
38.500
−1.171
1.00
22.67
C


ATOM
702
CG
ASP
A
59
−66.126
38.092
.213
1.00
23.91
C


ATOM
703
OD1
ASP
A
59
−65.271
37.182
.338
1.00
23.77
O


ATOM
704
OD2
ASP
A
59
−66.641
38.718
1.178
1.00
27.12
O


ATOM
705
C
ASP
A
59
−67.304
36.216
−1.901
1.00
21.79
C


ATOM
706
O
ASP
A
59
−66.828
35.102
−1.668
1.00
21.71
O


ATOM
708
N
ASN
A
60
−68.610
36.466
−1.926
1.00
21.51
N


ATOM
709
CA
ASN
A
60
−69.619
35.418
−1.759
1.00
21.28
C


ATOM
711
CB
ASN
A
60
−71.012
36.006
−1.958
1.00
21.25
C


ATOM
714
CG
ASN
A
60
−71.476
36.827
−.776
1.00
21.82
C


ATOM
715
OD1
ASN
A
60
−71.067
36.598
.364
1.00
20.81
O


ATOM
716
ND2
ASN
A
60
−72.361
37.783
−1.043
1.00
23.63
N


ATOM
719
C
ASN
A
60
−69.445
34.240
−2.725
1.00
21.22
C


ATOM
720
O
ASN
A
60
−69.444
33.053
−2.303
1.00
20.95
O


ATOM
722
N
VAL
A
61
−69.308
34.566
−4.018
1.00
20.83
N


ATOM
723
CA
VAL
A
61
−69.147
33.536
−5.043
1.00
20.57
C


ATOM
725
CB
VAL
A
61
−68.915
34.122
−6.466
1.00
20.53
C


ATOM
727
CG1
VAL
A
61
−68.382
33.042
−7.430
1.00
19.44
C


ATOM
731
CG2
VAL
A
61
−70.190
34.758
−7.006
1.00
19.75
C


ATOM
735
C
VAL
A
61
−67.981
32.646
−4.644
1.00
20.62
C


ATOM
736
O
VAL
A
61
−68.080
31.431
−4.699
1.00
20.56
O


ATOM
738
N
GLN
A
62
−66.888
33.255
−4.209
1.00
20.76
N


ATOM
739
CA
GLN
A
62
−65.703
32.481
−3.898
1.00
21.18
C


ATOM
741
CB
GLN
A
62
−64.461
33.379
−3.824
1.00
21.39
C


ATOM
744
CG
GLN
A
62
−64.007
33.920
−5.165
1.00
21.64
C


ATOM
747
CD
GLN
A
62
−62.608
34.512
−5.135
1.00
22.04
C


ATOM
748
OE1
GLN
A
62
−61.890
34.483
−6.145
1.00
23.18
O


ATOM
749
NE2
GLN
A
62
−62.217
35.062
−3.989
1.00
20.39
N


ATOM
752
C
GLN
A
62
−65.891
31.681
−2.607
1.00
21.09
C


ATOM
753
O
GLN
A
62
−65.544
30.485
−2.554
1.00
21.30
O


ATOM
755
N
ARG
A
63
−66.448
32.325
−1.583
1.00
20.63
N


ATOM
756
CA
ARG
A
63
−66.590
31.677
−.273
1.00
20.54
C


ATOM
758
CB
ARG
A
63
−67.025
32.686
.786
1.00
20.57
C


ATOM
761
CG
ARG
A
63
−66.031
33.823
.930
1.00
22.55
C


ATOM
764
CD
ARG
A
63
−66.214
34.632
2.179
1.00
24.93
C


ATOM
767
NE
ARG
A
63
−66.123
33.781
3.355
1.00
27.75
N


ATOM
769
CZ
ARG
A
63
−66.496
34.151
4.573
1.00
30.24
C


ATOM
770
NH1
ARG
A
63
−66.971
35.385
4.782
1.00
31.79
N


ATOM
773
NH2
ARG
A
63
−66.399
33.285
5.581
1.00
30.07
N


ATOM
776
C
ARG
A
63
−67.557
30.499
−.338
1.00
19.81
C


ATOM
777
O
ARG
A
63
−67.283
29.431
.209
1.00
19.67
O


ATOM
779
N
LEU
A
64
−68.661
30.684
−1.057
1.00
19.04
N


ATOM
780
CA
LEU
A
64
−69.636
29.617
−1.246
1.00
18.44
C


ATOM
782
CB
LEU
A
64
−70.865
30.167
−1.954
1.00
18.59
C


ATOM
785
CG
LEU
A
64
−71.662
31.170
−1.140
1.00
18.32
C


ATOM
787
CD1
LEU
A
64
−72.669
31.852
−2.034
1.00
18.10
C


ATOM
791
CD2
LEU
A
64
−72.334
30.444
.004
1.00
18.29
C


ATOM
795
C
LEU
A
64
−69.089
28.436
−2.037
1.00
17.80
C


ATOM
796
O
LEU
A
64
−69.802
27.453
−2.252
1.00
17.79
O


ATOM
798
N
GLY
A
65
−67.850
28.573
−2.515
1.00
17.07
N


ATOM
799
CA
GLY
A
65
−67.084
27.480
−3.081
1.00
16.27
C


ATOM
802
C
GLY
A
65
−67.137
27.406
−4.588
1.00
15.77
C


ATOM
803
O
GLY
A
65
−66.893
26.347
−5.154
1.00
15.78
O


ATOM
805
N
LEU
A
66
−67.439
28.521
−5.246
1.00
15.24
N


ATOM
806
CA
LEU
A
66
−67.621
28.537
−6.701
1.00
14.93
C


ATOM
808
CB
LEU
A
66
−68.977
29.146
−7.021
1.00
14.84
C


ATOM
811
CG
LEU
A
66
−70.204
28.334
−6.619
1.00
13.97
C


ATOM
813
CD1
LEU
A
66
−71.391
29.260
−6.650
1.00
13.74
C


ATOM
817
CD2
LEU
A
66
−70.415
27.125
−7.534
1.00
11.22
C


ATOM
821
C
LEU
A
66
−66.533
29.314
−7.454
1.00
15.09
C


ATOM
822
O
LEU
A
66
−66.621
29.497
−8.678
1.00
14.81
O


ATOM
824
N
GLY
A
67
−65.510
29.758
−6.720
1.00
15.21
N


ATOM
825
CA
GLY
A
67
−64.404
30.526
−7.280
1.00
14.98
C


ATOM
828
C
GLY
A
67
−63.873
29.952
−8.569
1.00
14.60
C


ATOM
829
O
GLY
A
67
−63.891
30.619
−9.579
1.00
14.63
O


ATOM
831
N
TYR
A
68
−63.419
28.706
−8.523
1.00
14.57
N


ATOM
832
CA
TYR
A
68
−62.831
28.029
−9.688
1.00
14.72
C


ATOM
834
CB
TYR
A
68
−62.608
26.539
−9.372
1.00
14.73
C


ATOM
837
CG
TYR
A
68
−63.858
25.689
−9.330
1.00
12.47
C


ATOM
838
CD1
TYR
A
68
−64.163
24.826
−10.366
1.00
10.68
C


ATOM
840
CE1
TYR
A
68
−65.310
24.043
−10.340
1.00
10.55
C


ATOM
842
CZ
TYR
A
68
−66.163
24.119
−9.258
1.00
10.41
C


ATOM
843
OH
TYR
A
68
−67.311
23.349
−9.212
1.00
6.97
O


ATOM
845
CE2
TYR
A
68
−65.864
24.979
−8.210
1.00
11.44
C


ATOM
847
CD2
TYR
A
68
−64.722
25.750
−8.252
1.00
11.29
C


ATOM
849
C
TYR
A
68
−63.648
28.141
−10.980
1.00
15.31
C


ATOM
850
O
TYR
A
68
−63.106
28.230
−12.083
1.00
15.01
O


ATOM
852
N
ARG
A
69
−64.959
28.136
−10.816
1.00
16.03
N


ATOM
853
CA
ARG
A
69
−65.884
28.083
−11.922
1.00
16.67
C


ATOM
855
CB
ARG
A
69
−67.224
27.649
−11.348
1.00
16.58
C


ATOM
858
CG
ARG
A
69
−68.332
27.445
−12.335
1.00
16.07
C


ATOM
861
CD
ARG
A
69
−69.378
26.578
−11.701
1.00
14.26
C


ATOM
864
NE
ARG
A
69
−68.915
25.205
−11.677
1.00
12.82
N


ATOM
866
CZ
ARG
A
69
−69.063
24.346
−12.676
1.00
12.42
C


ATOM
867
NH1
ARG
A
69
−69.676
24.694
−13.792
1.00
12.27
N


ATOM
870
NH2
ARG
A
69
−68.601
23.119
−12.553
1.00
13.23
N


ATOM
873
C
ARG
A
69
−66.010
29.409
−12.692
1.00
17.62
C


ATOM
874
O
ARG
A
69
−66.281
29.401
−13.892
1.00
17.10
O


ATOM
876
N
PHE
A
70
−65.811
30.529
−11.985
1.00
19.11
N


ATOM
877
CA
PHE
A
70
−65.936
31.891
−12.530
1.00
19.96
C


ATOM
879
CB
PHE
A
70
−67.024
32.666
−11.763
1.00
19.89
C


ATOM
882
CG
PHE
A
70
−68.365
32.010
−11.784
1.00
18.68
C


ATOM
883
CD1
PHE
A
70
−69.158
32.082
−12.903
1.00
18.05
C


ATOM
885
CE1
PHE
A
70
−70.376
31.452
−12.938
1.00
18.03
C


ATOM
887
CZ
PHE
A
70
−70.825
30.754
−11.851
1.00
17.26
C


ATOM
889
CE2
PHE
A
70
−70.051
30.672
−10.736
1.00
17.60
C


ATOM
891
CD2
PHE
A
70
−68.822
31.300
−10.700
1.00
17.86
C


ATOM
893
C
PHE
A
70
−64.627
32.661
−12.400
1.00
21.34
C


ATOM
894
O
PHE
A
70
−64.629
33.862
−12.171
1.00
21.25
O


ATOM
896
N
GLU
A
71
−63.501
31.977
−12.541
1.00
23.19
N


ATOM
897
CA
GLU
A
71
−62.211
32.591
−12.214
1.00
24.60
C


ATOM
899
CB
GLU
A
71
−61.127
31.524
−12.073
1.00
25.03
C


ATOM
902
CG
GLU
A
71
−59.717
32.059
−11.861
1.00
27.10
C


ATOM
905
CD
GLU
A
71
−58.712
30.949
−11.549
1.00
30.10
C


ATOM
906
OE1
GLU
A
71
−59.084
30.007
−10.796
1.00
32.05
O


ATOM
907
OE2
GLU
A
71
−57.558
31.027
−12.051
1.00
30.50
O


ATOM
908
C
GLU
A
71
−61.809
33.644
−13.241
1.00
25.23
C


ATOM
909
O
GLU
A
71
−61.362
34.717
−12.862
1.00
25.54
O


ATOM
911
N
SER
A
72
−61.979
33.345
−14.530
1.00
25.91
N


ATOM
912
CA
SER
A
72
−61.641
34.294
−15.588
1.00
26.37
C


ATOM
914
CB
SER
A
72
−61.656
33.606
−16.941
1.00
26.32
C


ATOM
917
OG
SER
A
72
−62.985
33.278
−17.291
1.00
27.28
O


ATOM
919
C
SER
A
72
−62.609
35.476
−15.608
1.00
26.84
C


ATOM
920
O
SER
A
72
−62.197
36.601
−15.852
1.00
27.02
O


ATOM
922
N
ASP
A
73
−63.893
35.214
−15.361
1.00
27.45
N


ATOM
923
CA
ASP
A
73
−64.895
36.277
−15.246
1.00
27.87
C


ATOM
925
CB
ASP
A
73
−66.289
35.705
−14.968
1.00
27.99
C


ATOM
928
CG
ASP
A
73
−66.842
34.913
−16.140
1.00
29.49
C


ATOM
929
OD1
ASP
A
73
−67.215
35.530
−17.155
1.00
30.90
O


ATOM
930
OD2
ASP
A
73
−66.916
33.667
−16.054
1.00
31.85
O


ATOM
931
C
ASP
A
73
−64.518
37.221
−14.121
1.00
27.86
C


ATOM
932
O
ASP
A
73
−64.598
38.435
−14.286
1.00
28.05
O


ATOM
934
N
ILE
A
74
−64.118
36.652
−12.985
1.00
27.88
N


ATOM
935
CA
ILE
A
74
−63.698
37.422
−11.821
1.00
27.98
C


ATOM
937
CB
ILE
A
74
−63.348
36.521
−10.637
1.00
27.71
C


ATOM
939
CG1
ILE
A
74
−64.607
36.007
−9.960
1.00
27.60
C


ATOM
942
CD1
ILE
A
74
−64.355
34.846
−9.023
1.00
27.67
C


ATOM
946
CG2
ILE
A
74
−62.551
37.272
−9.621
1.00
26.82
C


ATOM
950
C
ILE
A
74
−62.472
38.252
−12.133
1.00
28.80
C


ATOM
951
O
ILE
A
74
−62.475
39.453
−11.917
1.00
29.00
O


ATOM
953
N
ARG
A
75
−61.415
37.616
−12.628
1.00
29.80
N


ATOM
954
CA
ARG
A
75
−60.197
38.341
−12.968
1.00
30.79
C


ATOM
956
CB
ARG
A
75
−59.286
37.507
−13.841
1.00
31.33
C


ATOM
959
CG
ARG
A
75
−58.506
36.441
−13.115
1.00
34.25
C


ATOM
962
CD
ARG
A
75
−57.286
36.009
−13.929
1.00
37.53
C


ATOM
965
NE
ARG
A
75
−56.238
37.019
−13.799
1.00
40.89
N


ATOM
967
CZ
ARG
A
75
−54.934
36.807
−13.967
1.00
44.24
C


ATOM
968
NH1
ARG
A
75
−54.459
35.602
−14.294
1.00
45.02
N


ATOM
971
NH2
ARG
A
75
−54.089
37.821
−13.796
1.00
45.88
N


ATOM
974
C
ARG
A
75
−60.548
39.596
−13.727
1.00
30.95
C


ATOM
975
O
ARG
A
75
−60.163
40.685
−13.336
1.00
31.27
O


ATOM
977
N
ARG
A
76
−61.293
39.435
−14.815
1.00
31.31
N


ATOM
978
CA
ARG
A
76
−61.712
40.567
−15.638
1.00
31.62
C


ATOM
980
CB
ARG
A
76
−62.593
40.106
−16.794
1.00
31.97
C


ATOM
983
CG
ARG
A
76
−61.833
39.392
−17.895
1.00
32.91
C


ATOM
986
CD
ARG
A
76
−62.615
39.453
−19.205
1.00
34.43
C


ATOM
989
NE
ARG
A
76
−63.925
38.803
−19.128
1.00
35.66
N


ATOM
991
CZ
ARG
A
76
−64.115
37.480
−19.106
1.00
37.15
C


ATOM
992
NH1
ARG
A
76
−63.085
36.632
−19.129
1.00
37.93
N


ATOM
995
NH2
ARG
A
76
−65.347
36.992
−19.048
1.00
37.64
N


ATOM
998
C
ARG
A
76
−62.453
41.629
−14.849
1.00
31.41
C


ATOM
999
O
ARG
A
76
−62.144
42.798
−14.966
1.00
31.35
O


ATOM
1001
N
ALA
A
77
−63.437
41.230
−14.058
1.00
31.53
N


ATOM
1002
CA
ALA
A
77
−64.136
42.177
−13.211
1.00
31.73
C


ATOM
1004
CB
ALA
A
77
−65.074
41.468
−12.275
1.00
31.69
C


ATOM
1008
C
ALA
A
77
−63.107
42.950
−12.423
1.00
32.23
C


ATOM
1009
O
ALA
A
77
−63.116
44.176
−12.411
1.00
32.42
O


ATOM
1011
N
LEU
A
78
−62.198
42.223
−11.786
1.00
32.95
N


ATOM
1012
CA
LEU
A
78
−61.168
42.838
−10.963
1.00
33.51
C


ATOM
1014
CB
LEU
A
78
−60.319
41.775
−10.265
1.00
33.10
C


ATOM
1017
CG
LEU
A
78
−60.959
41.077
−9.081
1.00
32.30
C


ATOM
1019
CD1
LEU
A
78
−59.960
40.104
−8.472
1.00
30.80
C


ATOM
1023
CD2
LEU
A
78
−61.438
42.117
−8.056
1.00
31.89
C


ATOM
1027
C
LEU
A
78
−60.249
43.752
−11.753
1.00
34.70
C


ATOM
1028
O
LEU
A
78
−59.790
44.753
−11.214
1.00
35.18
O


ATOM
1030
N
ASP
A
79
−59.955
43.404
−13.007
1.00
35.91
N


ATOM
1031
CA
ASP
A
79
−59.054
44.205
−13.828
1.00
36.89
C


ATOM
1033
CB
ASP
A
79
−58.637
43.452
−15.083
1.00
37.06
C


ATOM
1036
CG
ASP
A
79
−57.518
44.150
−15.821
1.00
38.41
C


ATOM
1037
OD1
ASP
A
79
−57.800
45.080
−16.615
1.00
39.85
O


ATOM
1038
OD2
ASP
A
79
−56.347
43.775
−15.592
1.00
40.78
O


ATOM
1039
C
ASP
A
79
−59.721
45.505
−14.220
1.00
37.75
C


ATOM
1040
O
ASP
A
79
−59.105
46.568
−14.177
1.00
37.82
O


ATOM
1042
N
ARG
A
80
−60.984
45.401
−14.615
1.00
38.99
N


ATOM
1043
CA
ARG
A
80
−61.814
46.558
−14.923
1.00
39.88
C


ATOM
1045
CB
ARG
A
80
−63.191
46.106
−15.427
1.00
40.41
C


ATOM
1048
CG
ARG
A
80
−64.025
47.183
−16.122
1.00
42.77
C


ATOM
1051
CD
ARG
A
80
−65.347
46.624
−16.718
1.00
45.79
C


ATOM
1054
NE
ARG
A
80
−66.107
45.799
−15.765
1.00
48.55
N


ATOM
1056
CZ
ARG
A
80
−66.136
44.457
−15.742
1.00
50.37
C


ATOM
1057
NH1
ARG
A
80
−65.450
43.724
−16.636
1.00
49.78
N


ATOM
1060
NH2
ARG
A
80
−66.868
43.835
−14.805
1.00
50.77
N


ATOM
1063
C
ARG
A
80
−61.946
47.409
−13.668
1.00
39.80
C


ATOM
1064
O
ARG
A
80
−61.840
48.630
−13.742
1.00
40.37
O


ATOM
1066
N
PHE
A
81
−62.136
46.771
−12.516
1.00
39.62
N


ATOM
1067
CA
PHE
A
81
−62.216
47.505
−11.245
1.00
39.61
C


ATOM
1069
CB
PHE
A
81
−62.392
46.561
−10.053
1.00
39.74
C


ATOM
1072
CG
PHE
A
81
−62.282
47.247
−8.712
1.00
38.81
C


ATOM
1073
CD1
PHE
A
81
−63.238
48.153
−8.315
1.00
39.03
C


ATOM
1075
CE1
PHE
A
81
−63.153
48.787
−7.100
1.00
39.69
C


ATOM
1077
CZ
PHE
A
81
−62.095
48.515
−6.261
1.00
39.54
C


ATOM
1079
CE2
PHE
A
81
−61.134
47.608
−6.647
1.00
38.66
C


ATOM
1081
CD2
PHE
A
81
−61.228
46.986
−7.865
1.00
38.27
C


ATOM
1083
C
PHE
A
81
−61.006
48.378
−10.970
1.00
39.58
C


ATOM
1084
O
PHE
A
81
−61.165
49.535
−10.581
1.00
39.76
O


ATOM
1086
N
VAL
A
82
−59.810
47.817
−11.142
1.00
39.50
N


ATOM
1087
CA
VAL
A
82
−58.575
48.562
−10.892
1.00
39.47
C


ATOM
1089
CB
VAL
A
82
−57.314
47.659
−10.977
1.00
39.37
C


ATOM
1091
CG1
VAL
A
82
−56.108
48.426
−11.521
1.00
39.06
C


ATOM
1095
CG2
VAL
A
82
−57.009
47.079
−9.614
1.00
39.23
C


ATOM
1099
C
VAL
A
82
−58.457
49.755
−11.833
1.00
39.54
C


ATOM
1100
O
VAL
A
82
−58.222
50.884
−11.378
1.00
39.45
O


ATOM
1102
N
SER
A
83
−58.678
49.513
−13.126
1.00
39.65
N


ATOM
1103
CA
SER
A
83
−58.469
50.535
−14.157
1.00
39.82
C


ATOM
1105
CB
SER
A
83
−58.196
49.880
−15.526
1.00
39.84
C


ATOM
1108
OG
SER
A
83
−59.138
48.870
−15.829
1.00
40.00
O


ATOM
1110
C
SER
A
83
−59.617
51.561
−14.219
1.00
39.62
C


ATOM
1111
O
SER
A
83
−60.149
51.853
−15.286
1.00
39.59
O


ATOM
1113
N
SER
A
84
−59.957
52.108
−13.052
1.00
39.44
N


ATOM
1114
CA
SER
A
84
−60.926
53.197
−12.910
1.00
39.13
C


ATOM
1116
CB
SER
A
84
−62.238
52.834
−13.618
1.00
39.03
C


ATOM
1119
OG
SER
A
84
−62.620
51.505
−13.325
1.00
37.97
O


ATOM
1121
C
SER
A
84
−61.243
53.580
−11.446
1.00
39.17
C


ATOM
1122
O
SER
A
84
−62.189
54.341
−11.230
1.00
39.58
O


ATOM
1124
N
GLY
A
85
−60.482
53.077
−10.457
1.00
38.74
N


ATOM
1125
CA
GLY
A
85
−60.795
53.282
−9.024
1.00
38.26
C


ATOM
1128
C
GLY
A
85
−61.724
52.238
−8.413
1.00
37.79
C


ATOM
1129
O
GLY
A
85
−61.529
51.799
−7.273
1.00
36.84
O


ATOM
1131
N
SER
A
94
−63.557
54.187
1.994
1.00
28.27
N


ATOM
1132
CA
SER
A
94
−64.069
52.892
2.476
1.00
28.03
C


ATOM
1134
CB
SER
A
94
−64.856
52.225
1.359
1.00
27.84
C


ATOM
1137
OG
SER
A
94
−65.234
50.921
1.743
1.00
28.20
O


ATOM
1139
C
SER
A
94
−62.992
51.910
2.934
1.00
27.83
C


ATOM
1140
O
SER
A
94
−62.339
51.325
2.090
1.00
28.15
O


ATOM
1142
N
LEU
A
95
−62.815
51.705
4.245
1.00
27.70
N


ATOM
1143
CA
LEU
A
95
−61.813
50.728
4.751
1.00
27.59
C


ATOM
1145
CB
LEU
A
95
−61.692
50.747
6.282
1.00
27.49
C


ATOM
1148
CG
LEU
A
95
−60.871
49.596
6.909
1.00
27.47
C


ATOM
1150
CD1
LEU
A
95
−59.400
49.900
6.902
1.00
27.70
C


ATOM
1154
CD2
LEU
A
95
−61.292
49.274
8.329
1.00
27.50
C


ATOM
1158
C
LEU
A
95
−62.173
49.314
4.318
1.00
27.71
C


ATOM
1159
O
LEU
A
95
−61.303
48.537
3.914
1.00
27.73
O


ATOM
1161
N
HIS
A
96
−63.461
48.989
4.437
1.00
27.74
N


ATOM
1162
CA
HIS
A
96
−64.003
47.715
3.977
1.00
27.54
C


ATOM
1164
CB
HIS
A
96
−65.497
47.680
4.230
1.00
27.57
C


ATOM
1167
CG
HIS
A
96
−66.161
46.482
3.654
1.00
28.65
C


ATOM
1168
ND1
HIS
A
96
−65.790
45.201
3.988
1.00
30.59
N


ATOM
1170
CE1
HIS
A
96
−66.540
44.341
3.325
1.00
31.88
C


ATOM
1172
NE2
HIS
A
96
−67.384
45.021
2.570
1.00
32.06
N


ATOM
1174
CD2
HIS
A
96
−67.166
46.364
2.758
1.00
30.47
C


ATOM
1176
C
HIS
A
96
−63.705
47.450
2.492
1.00
27.09
C


ATOM
1177
O
HIS
A
96
−63.128
46.425
2.150
1.00
27.18
O


ATOM
1179
N
GLY
A
97
−64.079
48.386
1.625
1.00
26.55
N


ATOM
1180
CA
GLY
A
97
−63.760
48.300
.205
1.00
26.26
C


ATOM
1183
C
GLY
A
97
−62.277
48.112
−.088
1.00
26.23
C


ATOM
1184
O
GLY
A
97
−61.918
47.334
−.974
1.00
26.39
O


ATOM
1186
N
THR
A
98
−61.415
48.815
.653
1.00
25.83
N


ATOM
1187
CA
THR
A
98
−59.967
48.755
.435
1.00
25.36
C


ATOM
1189
CB
THR
A
98
−59.204
49.847
1.215
1.00
25.07
C


ATOM
1191
OG1
THR
A
98
−59.796
51.123
.980
1.00
23.62
O


ATOM
1193
CG2
THR
A
98
−57.755
49.905
.780
1.00
24.88
C


ATOM
1197
C
THR
A
98
−59.416
47.389
.845
1.00
25.69
C


ATOM
1198
O
THR
A
98
−58.622
46.802
.111
1.00
25.66
O


ATOM
1200
N
ALA
A
99
−59.847
46.890
2.008
1.00
25.95
N


ATOM
1201
CA
ALA
A
99
−59.468
45.540
2.495
1.00
25.93
C


ATOM
1203
CB
ALA
A
99
−59.945
45.330
3.929
1.00
25.82
C


ATOM
1207
C
ALA
A
99
−59.984
44.404
1.595
1.00
25.64
C


ATOM
1208
O
ALA
A
99
−59.204
43.599
1.102
1.00
25.38
O


ATOM
1210
N
LEU
A
100
−61.290
44.348
1.371
1.00
25.46
N


ATOM
1211
CA
LEU
A
100
−61.856
43.335
.474
1.00
25.55
C


ATOM
1213
CB
LEU
A
100
−63.361
43.540
.326
1.00
25.37
C


ATOM
1216
CG
LEU
A
100
−64.118
42.464
−.443
1.00
25.41
C


ATOM
1218
CD1
LEU
A
100
−64.038
41.115
.281
1.00
26.01
C


ATOM
1222
CD2
LEU
A
100
−65.555
42.893
−.639
1.00
25.19
C


ATOM
1226
C
LEU
A
100
−61.196
43.353
−.919
1.00
25.70
C


ATOM
1227
O
LEU
A
100
−60.819
42.301
−1.469
1.00
25.36
O


ATOM
1229
N
SER
A
101
−61.064
44.550
−1.489
1.00
25.77
N


ATOM
1230
CA
SER
A
101
−60.434
44.688
−2.805
1.00
25.67
C


ATOM
1232
CB
SER
A
101
−60.629
46.098
−3.375
1.00
25.83
C


ATOM
1235
OG
SER
A
101
−59.840
47.064
−2.688
1.00
26.98
O


ATOM
1237
C
SER
A
101
−58.947
44.336
−2.756
1.00
25.01
C


ATOM
1238
O
SER
A
101
−58.427
43.705
−3.672
1.00
24.94
O


ATOM
1240
N
PHE
A
102
−58.270
44.737
−1.687
1.00
24.30
N


ATOM
1241
CA
PHE
A
102
−56.852
44.436
−1.560
1.00
23.99
C


ATOM
1243
CB
PHE
A
102
−56.295
44.963
−.229
1.00
23.84
C


ATOM
1246
CG
PHE
A
102
−54.860
44.606
.027
1.00
23.24
C


ATOM
1247
CD1
PHE
A
102
−53.849
45.504
−.259
1.00
23.56
C


ATOM
1249
CE1
PHE
A
102
−52.507
45.182
−.007
1.00
24.50
C


ATOM
1251
CZ
PHE
A
102
−52.175
43.941
.540
1.00
24.27
C


ATOM
1253
CE2
PHE
A
102
−53.180
43.042
.834
1.00
23.95
C


ATOM
1255
CD2
PHE
A
102
−54.520
43.376
.576
1.00
23.45
C


ATOM
1257
C
PHE
A
102
−56.673
42.928
−1.679
1.00
23.65
C


ATOM
1258
O
PHE
A
102
−55.890
42.442
−2.501
1.00
23.55
O


ATOM
1260
N
ARG
A
103
−57.443
42.202
−.880
1.00
23.20
N


ATOM
1261
CA
ARG
A
103
−57.298
40.765
−.764
1.00
22.84
C


ATOM
1263
CB
ARG
A
103
−58.250
40.231
.291
1.00
23.01
C


ATOM
1266
CG
ARG
A
103
−58.054
38.774
.597
1.00
23.93
C


ATOM
1269
CD
ARG
A
103
−58.703
38.376
1.937
1.00
23.84
C


ATOM
1272
NE
ARG
A
103
−60.150
38.538
1.919
1.00
22.36
N


ATOM
1274
CZ
ARG
A
103
−60.982
37.763
1.240
1.00
20.62
C


ATOM
1275
NH1
ARG
A
103
−60.512
36.773
.490
1.00
20.19
N


ATOM
1278
NH2
ARG
A
103
−62.288
38.003
1.293
1.00
20.32
N


ATOM
1281
C
ARG
A
103
−57.602
40.117
−2.082
1.00
22.34
C


ATOM
1282
O
ARG
A
103
−56.826
39.303
−2.576
1.00
22.37
O


ATOM
1284
N
LEU
A
104
−58.729
40.496
−2.667
1.00
21.98
N


ATOM
1285
CA
LEU
A
104
−59.129
39.926
−3.951
1.00
21.60
C


ATOM
1287
CB
LEU
A
104
−60.503
40.442
−4.378
1.00
21.23
C


ATOM
1290
CG
LEU
A
104
−61.590
39.832
−3.522
1.00
20.30
C


ATOM
1292
CD1
LEU
A
104
−62.949
40.401
−3.856
1.00
19.53
C


ATOM
1296
CD2
LEU
A
104
−61.554
38.344
−3.725
1.00
19.71
C


ATOM
1300
C
LEU
A
104
−58.101
40.198
−5.040
1.00
21.48
C


ATOM
1301
O
LEU
A
104
−57.743
39.294
−5.780
1.00
21.62
O


ATOM
1303
N
LEU
A
105
−57.623
41.432
−5.139
1.00
21.14
N


ATOM
1304
CA
LEU
A
105
−56.655
41.747
−6.173
1.00
21.05
C


ATOM
1306
CB
LEU
A
105
−56.352
43.248
−6.205
1.00
20.94
C


ATOM
1309
CG
LEU
A
105
−57.465
44.165
−6.732
1.00
20.06
C


ATOM
1311
CD1
LEU
A
105
−57.060
45.617
−6.580
1.00
17.92
C


ATOM
1315
CD2
LEU
A
105
−57.804
43.857
−8.174
1.00
19.18
C


ATOM
1319
C
LEU
A
105
−55.372
40.908
−5.997
1.00
21.32
C


ATOM
1320
O
LEU
A
105
−54.840
40.357
−6.976
1.00
21.37
O


ATOM
1322
N
ARG
A
106
−54.893
40.777
−4.763
1.00
21.25
N


ATOM
1323
CA
ARG
A
106
−53.678
40.003
−4.528
1.00
21.33
C


ATOM
1325
CB
ARG
A
106
−53.151
40.211
−3.117
1.00
21.53
C


ATOM
1328
CG
ARG
A
106
−51.772
39.588
−2.917
1.00
22.60
C


ATOM
1331
CD
ARG
A
106
−51.098
40.091
−1.666
1.00
23.60
C


ATOM
1334
NE
ARG
A
106
−50.374
41.330
−1.897
1.00
24.60
N


ATOM
1336
CZ
ARG
A
106
−49.606
41.916
−.989
1.00
26.54
C


ATOM
1337
NH1
ARG
A
106
−49.469
41.380
.225
1.00
26.98
N


ATOM
1340
NH2
ARG
A
106
−48.967
43.041
−1.295
1.00
27.19
N


ATOM
1343
C
ARG
A
106
−53.888
38.517
−4.767
1.00
21.19
C


ATOM
1344
O
ARG
A
106
−52.998
37.821
−5.278
1.00
21.18
O


ATOM
1346
N
GLN
A
107
−55.061
38.028
−4.378
1.00
21.09
N


ATOM
1347
CA
GLN
A
107
−55.425
36.635
−4.618
1.00
20.76
C


ATOM
1349
CB
GLN
A
107
−56.861
36.378
−4.168
1.00
20.51
C


ATOM
1352
CG
GLN
A
107
−57.329
34.941
−4.327
1.00
19.68
C


ATOM
1355
CD
GLN
A
107
−58.790
34.772
−4.010
1.00
18.26
C


ATOM
1356
OE1
GLN
A
107
−59.395
35.591
−3.334
1.00
17.44
O


ATOM
1357
NE2
GLN
A
107
−59.366
33.698
−4.497
1.00
18.48
N


ATOM
1360
C
GLN
A
107
−55.304
36.306
−6.094
1.00
20.93
C


ATOM
1361
O
GLN
A
107
−54.917
35.212
−6.447
1.00
21.45
O


ATOM
1363
N
HIS
A
108
−55.642
37.260
−6.951
1.00
21.09
N


ATOM
1364
CA
HIS
A
108
−55.686
37.030
−8.379
1.00
21.28
C


ATOM
1366
CB
HIS
A
108
−57.024
37.541
−8.913
1.00
21.02
C


ATOM
1369
CG
HIS
A
108
−58.182
36.706
−8.478
1.00
19.70
C


ATOM
1370
ND1
HIS
A
108
−58.637
35.632
−9.210
1.00
19.91
N


ATOM
1372
CE1
HIS
A
108
−59.641
35.060
−8.571
1.00
19.27
C


ATOM
1374
NE2
HIS
A
108
−59.851
35.720
−7.449
1.00
18.10
N


ATOM
1376
CD2
HIS
A
108
−58.950
36.753
−7.367
1.00
18.98
C


ATOM
1378
C
HIS
A
108
−54.456
37.621
−9.108
1.00
22.21
C


ATOM
1379
O
HIS
A
108
−54.505
37.980
−10.304
1.00
21.80
O


ATOM
1381
N
GLY
A
109
−53.345
37.686
−8.375
1.00
23.19
N


ATOM
1382
CA
GLY
A
109
−52.055
38.007
−8.956
1.00
24.17
C


ATOM
1385
C
GLY
A
109
−51.813
39.470
−9.275
1.00
25.25
C


ATOM
1386
O
GLY
A
109
−50.767
39.802
−9.845
1.00
25.26
O


ATOM
1388
N
PHE
A
110
−52.755
40.349
−8.917
1.00
26.42
N


ATOM
1389
CA
PHE
A
110
−52.575
41.783
−9.154
1.00
27.33
C


ATOM
1391
CB
PHE
A
110
−53.895
42.546
−9.067
1.00
27.36
C


ATOM
1394
CG
PHE
A
110
−54.838
42.250
−10.193
1.00
27.83
C


ATOM
1395
CD1
PHE
A
110
−54.633
42.801
−11.439
1.00
28.69
C


ATOM
1397
CE1
PHE
A
110
−55.490
42.529
−12.488
1.00
28.91
C


ATOM
1399
CZ
PHE
A
110
−56.568
41.702
−12.295
1.00
28.85
C


ATOM
1401
CE2
PHE
A
110
−56.787
41.146
−11.060
1.00
28.67
C


ATOM
1403
CD2
PHE
A
110
−55.923
41.418
−10.013
1.00
28.39
C


ATOM
1405
C
PHE
A
110
−51.582
42.369
−8.163
1.00
28.25
C


ATOM
1406
O
PHE
A
110
−51.449
41.890
−7.024
1.00
28.71
O


ATOM
1408
N
GLU
A
111
−50.886
43.411
−8.607
1.00
29.05
N


ATOM
1409
CA
GLU
A
111
−49.951
44.142
−7.760
1.00
29.66
C


ATOM
1411
CB
GLU
A
111
−48.902
44.803
−8.648
1.00
30.37
C


ATOM
1414
CG
GLU
A
111
−47.750
45.509
−7.947
1.00
33.30
C


ATOM
1417
CD
GLU
A
111
−46.916
46.342
−8.946
1.00
38.00
C


ATOM
1418
OE1
GLU
A
111
−46.312
45.750
−9.885
1.00
39.60
O


ATOM
1419
OE2
GLU
A
111
−46.886
47.594
−8.802
1.00
40.87
O


ATOM
1420
C
GLU
A
111
−50.724
45.184
−6.935
1.00
28.98
C


ATOM
1421
O
GLU
A
111
−51.293
46.123
−7.495
1.00
28.45
O


ATOM
1423
N
VAL
A
112
−50.787
44.961
−5.618
1.00
28.47
N


ATOM
1424
CA
VAL
A
112
−51.284
45.950
−4.655
1.00
28.09
C


ATOM
1426
CB
VAL
A
112
−52.564
45.501
−3.908
1.00
27.76
C


ATOM
1428
CG1
VAL
A
112
−53.745
45.466
−4.836
1.00
27.38
C


ATOM
1432
CG2
VAL
A
112
−52.360
44.167
−3.252
1.00
27.80
C


ATOM
1436
C
VAL
A
112
−50.193
46.199
−3.631
1.00
28.15
C


ATOM
1437
O
VAL
A
112
−49.339
45.354
−3.436
1.00
27.90
O


ATOM
1439
N
SER
A
113
−50.241
47.354
−2.974
1.00
28.54
N


ATOM
1440
CA
SER
A
113
−49.194
47.782
−2.047
1.00
28.93
C


ATOM
1442
CB
SER
A
113
−48.563
49.064
−2.564
1.00
29.12
C


ATOM
1445
OG
SER
A
113
−47.692
49.644
−1.619
1.00
29.57
O


ATOM
1447
C
SER
A
113
−49.780
48.041
−.685
1.00
29.13
C


ATOM
1448
O
SER
A
113
−50.937
48.426
−.581
1.00
28.90
O


ATOM
1450
N
GLN
A
114
−48.985
47.857
.367
1.00
29.84
N


ATOM
1451
CA
GLN
A
114
−49.524
48.019
1.736
1.00
30.40
C


ATOM
1453
CB
GLN
A
114
−48.568
47.507
2.830
1.00
30.34
C


ATOM
1456
CG
GLN
A
114
−47.199
48.159
2.844
1.00
30.61
C


ATOM
1459
CD
GLN
A
114
−46.456
47.928
4.147
1.00
30.77
C


ATOM
1460
OE1
GLN
A
114
−46.876
47.129
4.982
1.00
31.92
O


ATOM
1461
NE2
GLN
A
114
−45.341
48.624
4.324
1.00
30.02
N


ATOM
1464
C
GLN
A
114
−49.939
49.440
2.068
1.00
30.62
C


ATOM
1465
O
GLN
A
114
−50.573
49.644
3.094
1.00
30.73
O


ATOM
1467
N
GLU
A
115
−49.592
50.407
1.216
1.00
30.94
N


ATOM
1468
CA
GLU
A
115
−49.963
51.794
1.458
1.00
31.45
C


ATOM
1470
CB
GLU
A
115
−48.881
52.777
.975
1.00
31.86
C


ATOM
1473
CG
GLU
A
115
−48.489
52.723
−.509
1.00
33.48
C


ATOM
1476
CD
GLU
A
115
−47.006
53.100
−.759
1.00
36.13
C


ATOM
1477
OE1
GLU
A
115
−46.106
52.668
.022
1.00
38.72
O


ATOM
1478
OE2
GLU
A
115
−46.741
53.811
−1.754
1.00
35.70
O


ATOM
1479
C
GLU
A
115
−51.338
52.125
.895
1.00
31.45
C


ATOM
1480
O
GLU
A
115
−51.716
53.283
.808
1.00
31.80
O


ATOM
1482
N
ALA
A
116
−52.108
51.105
.549
1.00
31.58
N


ATOM
1483
CA
ALA
A
116
−53.524
51.286
.284
1.00
31.67
C


ATOM
1485
CB
ALA
A
116
−54.071
50.092
−.461
1.00
31.62
C


ATOM
1489
C
ALA
A
116
−54.273
51.473
1.596
1.00
31.88
C


ATOM
1490
O
ALA
A
116
−55.428
51.874
1.604
1.00
31.82
O


ATOM
1492
N
PHE
A
117
−53.608
51.161
2.702
1.00
32.39
N


ATOM
1493
CA
PHE
A
117
−54.193
51.271
4.030
1.00
32.87
C


ATOM
1495
CB
PHE
A
117
−53.884
50.003
4.856
1.00
32.79
C


ATOM
1498
CG
PHE
A
117
−54.539
48.758
4.323
1.00
31.03
C


ATOM
1499
CD1
PHE
A
117
−53.782
47.749
3.760
1.00
28.79
C


ATOM
1501
CE1
PHE
A
117
−54.379
46.620
3.265
1.00
28.36
C


ATOM
1503
CZ
PHE
A
117
−55.754
46.489
3.316
1.00
29.50
C


ATOM
1505
CE2
PHE
A
117
−56.527
47.493
3.872
1.00
29.91
C


ATOM
1507
CD2
PHE
A
117
−55.917
48.613
4.375
1.00
30.09
C


ATOM
1509
C
PHE
A
117
−53.683
52.493
4.773
1.00
33.71
C


ATOM
1510
O
PHE
A
117
−54.012
52.678
5.937
1.00
33.61
O


ATOM
1512
N
SER
A
118
−52.886
53.325
4.107
1.00
35.09
N


ATOM
1513
CA
SER
A
118
−52.186
54.429
4.779
1.00
36.12
C


ATOM
1515
CB
SER
A
118
−51.073
54.990
3.895
1.00
36.09
C


ATOM
1518
OG
SER
A
118
−51.607
55.747
2.820
1.00
35.96
O


ATOM
1520
C
SER
A
118
−53.134
55.552
5.184
1.00
37.17
C


ATOM
1521
O
SER
A
118
−52.873
56.255
6.166
1.00
37.22
O


ATOM
1523
N
GLY
A
119
−54.231
55.705
4.436
1.00
38.40
N


ATOM
1524
CA
GLY
A
119
−55.227
56.735
4.708
1.00
39.47
C


ATOM
1527
C
GLY
A
119
−56.255
56.398
5.778
1.00
40.62
C


ATOM
1528
O
GLY
A
119
−57.259
57.086
5.877
1.00
40.74
O


ATOM
1530
N
PHE
A
120
−56.024
55.344
6.563
1.00
42.13
N


ATOM
1531
CA
PHE
A
120
−56.906
54.971
7.684
1.00
43.27
C


ATOM
1533
CB
PHE
A
120
−57.510
53.586
7.455
1.00
43.21
C


ATOM
1536
CG
PHE
A
120
−58.176
53.439
6.134
1.00
42.36
C


ATOM
1537
CD1
PHE
A
120
−59.418
54.006
5.911
1.00
41.23
C


ATOM
1539
CE1
PHE
A
120
−60.035
53.880
4.691
1.00
40.87
C


ATOM
1541
CZ
PHE
A
120
−59.414
53.182
3.675
1.00
41.03
C


ATOM
1543
CE2
PHE
A
120
−58.167
52.618
3.883
1.00
40.92
C


ATOM
1545
CD2
PHE
A
120
−57.556
52.746
5.106
1.00
41.30
C


ATOM
1547
C
PHE
A
120
−56.179
54.952
9.019
1.00
44.71
C


ATOM
1548
O
PHE
A
120
−56.732
54.489
10.025
1.00
44.80
O


ATOM
1550
N
LYS
A
121
−54.939
55.430
9.021
1.00
46.38
N


ATOM
1551
CA
LYS
A
121
−54.153
55.519
10.235
1.00
47.81
C


ATOM
1553
CB
LYS
A
121
−52.722
55.050
9.957
1.00
47.86
C


ATOM
1556
CG
LYS
A
121
−52.648
53.537
9.648
1.00
48.24
C


ATOM
1559
CD
LYS
A
121
−51.417
53.119
8.823
1.00
49.41
C


ATOM
1562
CE
LYS
A
121
−50.095
53.142
9.621
1.00
49.88
C


ATOM
1565
NZ
LYS
A
121
−49.944
52.005
10.584
1.00
49.89
N


ATOM
1569
C
LYS
A
121
−54.257
56.964
10.735
1.00
49.00
C


ATOM
1570
O
LYS
A
121
−54.712
57.839
10.000
1.00
49.11
O


ATOM
1572
N
ASP
A
122
−53.899
57.206
11.995
1.00
50.51
N


ATOM
1573
CA
ASP
A
122
−54.078
58.537
12.596
1.00
51.46
C


ATOM
1575
CB
ASP
A
122
−54.604
58.443
14.050
1.00
51.29
C


ATOM
1578
CG
ASP
A
122
−53.570
57.919
15.036
1.00
50.73
C


ATOM
1579
OD1
ASP
A
122
−52.353
58.025
14.777
1.00
49.90
O


ATOM
1580
OD2
ASP
A
122
−53.988
57.398
16.088
1.00
49.66
O


ATOM
1581
C
ASP
A
122
−52.792
59.358
12.502
1.00
52.60
C


ATOM
1582
O
ASP
A
122
−51.830
58.953
11.835
1.00
52.65
O


ATOM
1584
N
GLN
A
123
−52.802
60.512
13.172
1.00
53.88
N


ATOM
1585
CA
GLN
A
123
−51.680
61.456
13.195
1.00
54.66
C


ATOM
1587
CB
GLN
A
123
−51.993
62.594
14.178
1.00
55.01
C


ATOM
1590
CG
GLN
A
123
−53.249
63.442
13.831
1.00
56.15
C


ATOM
1593
CD
GLN
A
123
−52.943
64.736
13.064
1.00
57.64
C


ATOM
1594
OE1
GLN
A
123
−51.779
65.102
12.859
1.00
59.10
O


ATOM
1595
NE2
GLN
A
123
−54.001
65.438
12.652
1.00
57.63
N


ATOM
1598
C
GLN
A
123
−50.365
60.772
13.591
1.00
54.87
C


ATOM
1599
O
GLN
A
123
−49.309
61.078
13.034
1.00
54.67
O


ATOM
1601
N
ASN
A
124
−50.458
59.834
14.538
1.00
55.21
N


ATOM
1602
CA
ASN
A
124
−49.300
59.137
15.109
1.00
55.39
C


ATOM
1604
CB
ASN
A
124
−49.421
59.122
16.637
1.00
55.52
C


ATOM
1607
CG
ASN
A
124
−49.833
60.478
17.202
1.00
55.98
C


ATOM
1608
OD1
ASN
A
124
−49.093
61.460
17.091
1.00
56.93
O


ATOM
1609
ND2
ASN
A
124
−51.026
60.540
17.797
1.00
55.99
N


ATOM
1612
C
ASN
A
124
−49.116
57.705
14.589
1.00
55.27
C


ATOM
1613
O
ASN
A
124
−48.530
56.864
15.271
1.00
55.18
O


ATOM
1615
N
GLY
A
125
−49.626
57.430
13.391
1.00
55.18
N


ATOM
1616
CA
GLY
A
125
−49.311
56.190
12.672
1.00
55.08
C


ATOM
1619
C
GLY
A
125
−49.994
54.897
13.119
1.00
54.90
C


ATOM
1620
O
GLY
A
125
−49.543
53.806
12.750
1.00
55.24
O


ATOM
1622
N
ASN
A
126
−51.072
55.008
13.900
1.00
54.23
N


ATOM
1623
CA
ASN
A
126
−51.871
53.853
14.329
1.00
53.39
C


ATOM
1625
CB
ASN
A
126
−51.927
53.782
15.852
1.00
53.27
C


ATOM
1628
CG
ASN
A
126
−50.596
53.425
16.466
1.00
52.81
C


ATOM
1629
OD1
ASN
A
126
−49.636
53.113
15.764
1.00
52.29
O


ATOM
1630
ND2
ASN
A
126
−50.532
53.460
17.789
1.00
52.53
N


ATOM
1633
C
ASN
A
126
−53.274
53.978
13.771
1.00
52.82
C


ATOM
1634
O
ASN
A
126
−53.724
55.081
13.494
1.00
52.69
O


ATOM
1636
N
PHE
A
127
−53.968
52.857
13.607
1.00
52.17
N


ATOM
1637
CA
PHE
A
127
−55.287
52.875
12.962
1.00
51.56
C


ATOM
1639
CB
PHE
A
127
−55.805
51.451
12.721
1.00
51.35
C


ATOM
1642
CG
PHE
A
127
−55.119
50.730
11.587
1.00
50.06
C


ATOM
1643
CD1
PHE
A
127
−54.068
49.856
11.831
1.00
48.90
C


ATOM
1645
CE1
PHE
A
127
−53.437
49.187
10.789
1.00
47.59
C


ATOM
1647
CZ
PHE
A
127
−53.857
49.383
9.495
1.00
47.40
C


ATOM
1649
CE2
PHE
A
127
−54.906
50.244
9.234
1.00
47.96
C


ATOM
1651
CD2
PHE
A
127
−55.533
50.915
10.276
1.00
48.85
C


ATOM
1653
C
PHE
A
127
−56.303
53.690
13.776
1.00
51.35
C


ATOM
1654
O
PHE
A
127
−56.347
53.594
15.002
1.00
51.09
O


ATOM
1656
N
LEU
A
128
−57.100
54.500
13.083
1.00
51.15
N


ATOM
1657
CA
LEU
A
128
−58.143
55.280
13.727
1.00
51.09
C


ATOM
1659
CB
LEU
A
128
−59.039
55.979
12.694
1.00
51.17
C


ATOM
1662
CG
LEU
A
128
−58.463
57.046
11.746
1.00
51.31
C


ATOM
1664
CD1
LEU
A
128
−59.571
57.628
10.855
1.00
50.76
C


ATOM
1668
CD2
LEU
A
128
−57.762
58.157
12.508
1.00
50.98
C


ATOM
1672
C
LEU
A
128
−58.996
54.353
14.581
1.00
51.06
C


ATOM
1673
O
LEU
A
128
−59.573
53.393
14.078
1.00
50.94
O


ATOM
1675
N
GLU
A
129
−59.053
54.637
15.879
1.00
51.12
N


ATOM
1676
CA
GLU
A
129
−59.916
53.913
16.808
1.00
50.99
C


ATOM
1678
CB
GLU
A
129
−60.019
54.665
18.132
1.00
51.14
C


ATOM
1681
CG
GLU
A
129
−58.850
54.431
19.049
1.00
52.04
C


ATOM
1684
CD
GLU
A
129
−58.903
53.069
19.697
1.00
53.22
C


ATOM
1685
OE1
GLU
A
129
−58.040
52.219
19.376
1.00
54.19
O


ATOM
1686
OE2
GLU
A
129
−59.823
52.848
20.516
1.00
53.51
O


ATOM
1687
C
GLU
A
129
−61.314
53.712
16.260
1.00
50.66
C


ATOM
1688
O
GLU
A
129
−61.791
52.587
16.200
1.00
50.83
O


ATOM
1690
N
ASN
A
130
−61.960
54.799
15.839
1.00
50.28
N


ATOM
1691
CA
ASN
A
130
−63.389
54.765
15.486
1.00
50.03
C


ATOM
1693
CB
ASN
A
130
−63.910
56.182
15.193
1.00
50.09
C


ATOM
1696
CG
ASN
A
130
−63.286
56.805
13.960
1.00
50.37
C


ATOM
1697
OD1
ASN
A
130
−62.504
56.177
13.249
1.00
51.44
O


ATOM
1698
ND2
ASN
A
130
−63.634
58.056
13.701
1.00
50.27
N


ATOM
1701
C
ASN
A
130
−63.804
53.782
14.369
1.00
49.56
C


ATOM
1702
O
ASN
A
130
−64.993
53.581
14.131
1.00
49.44
O


ATOM
1704
N
LEU
A
131
−62.828
53.175
13.699
1.00
49.21
N


ATOM
1705
CA
LEU
A
131
−63.087
52.103
12.729
1.00
48.78
C


ATOM
1707
CB
LEU
A
131
−61.846
51.832
11.875
1.00
48.64
C


ATOM
1710
CG
LEU
A
131
−61.445
52.939
10.898
1.00
48.26
C


ATOM
1712
CD1
LEU
A
131
−60.029
52.709
10.375
1.00
47.76
C


ATOM
1716
CD2
LEU
A
131
−62.441
53.039
9.754
1.00
47.32
C


ATOM
1720
C
LEU
A
131
−63.516
50.798
13.394
1.00
48.58
C


ATOM
1721
O
LEU
A
131
−64.093
49.939
12.731
1.00
48.64
O


ATOM
1723
N
LYS
A
132
−63.225
50.645
14.689
1.00
48.23
N


ATOM
1724
CA
LYS
A
132
−63.650
49.474
15.465
1.00
47.80
C


ATOM
1726
CB
LYS
A
132
−63.156
49.587
16.913
1.00
47.71
C


ATOM
1729
CG
LYS
A
132
−63.930
50.615
17.728
1.00
47.80
C


ATOM
1732
CD
LYS
A
132
−63.430
50.779
19.153
1.00
47.75
C


ATOM
1735
CE
LYS
A
132
−64.438
51.577
19.982
1.00
47.22
C


ATOM
1738
NZ
LYS
A
132
−63.769
52.364
21.033
1.00
46.65
N


ATOM
1742
C
LYS
A
132
−65.182
49.308
15.446
1.00
47.56
C


ATOM
1743
O
LYS
A
132
−65.696
48.204
15.616
1.00
47.76
O


ATOM
1745
N
GLU
A
133
−65.901
50.413
15.249
1.00
47.18
N


ATOM
1746
CA
GLU
A
133
−67.371
50.412
15.191
1.00
46.79
C


ATOM
1748
CB
GLU
A
133
−67.898
51.850
15.337
1.00
46.95
C


ATOM
1751
CG
GLU
A
133
−67.840
52.376
16.776
1.00
47.56
C


ATOM
1754
CD
GLU
A
133
−67.613
53.886
16.863
1.00
48.41
C


ATOM
1755
OE1
GLU
A
133
−68.247
54.648
16.093
1.00
47.67
O


ATOM
1756
OE2
GLU
A
133
−66.798
54.304
17.721
1.00
48.92
O


ATOM
1757
C
GLU
A
133
−67.949
49.770
13.918
1.00
46.10
C


ATOM
1758
O
GLU
A
133
−69.140
49.446
13.874
1.00
46.11
O


ATOM
1760
N
ASP
A
134
−67.103
49.601
12.896
1.00
45.11
N


ATOM
1761
CA
ASP
A
134
−67.477
48.995
11.608
1.00
44.06
C


ATOM
1763
CB
ASP
A
134
−66.934
49.868
10.474
1.00
43.97
C


ATOM
1766
CG
ASP
A
134
−67.380
49.411
9.104
1.00
44.08
C


ATOM
1767
OD1
ASP
A
134
−68.072
48.373
8.972
1.00
43.42
O


ATOM
1768
OD2
ASP
A
134
−67.020
50.116
8.141
1.00
44.84
O


ATOM
1769
C
ASP
A
134
−66.910
47.570
11.526
1.00
43.12
C


ATOM
1770
O
ASP
A
134
−65.788
47.357
11.080
1.00
43.19
O


ATOM
1772
N
ILE
A
135
−67.708
46.594
11.944
1.00
41.85
N


ATOM
1773
CA
ILE
A
135
−67.216
45.247
12.216
1.00
40.75
C


ATOM
1775
CB
ILE
A
135
−68.183
44.507
13.170
1.00
40.80
C


ATOM
1777
CG1
ILE
A
135
−68.227
45.226
14.524
1.00
41.21
C


ATOM
1780
CD1
ILE
A
135
−69.353
46.283
14.633
1.00
42.86
C


ATOM
1784
CG2
ILE
A
135
−67.776
43.063
13.373
1.00
40.88
C


ATOM
1788
C
ILE
A
135
−66.980
44.457
10.933
1.00
39.67
C


ATOM
1789
O
ILE
A
135
−66.166
43.537
10.901
1.00
39.37
O


ATOM
1791
N
LYS
A
136
−67.690
44.828
9.877
1.00
38.62
N


ATOM
1792
CA
LYS
A
136
−67.465
44.256
8.554
1.00
37.88
C


ATOM
1794
CB
LYS
A
136
−68.525
44.749
7.561
1.00
38.33
C


ATOM
1797
CG
LYS
A
136
−69.955
44.342
7.879
1.00
40.17
C


ATOM
1800
CD
LYS
A
136
−70.486
43.262
6.911
1.00
42.97
C


ATOM
1803
CE
LYS
A
136
−71.624
42.389
7.536
1.00
44.00
C


ATOM
1806
NZ
LYS
A
136
−72.950
43.086
7.726
1.00
43.82
N


ATOM
1810
C
LYS
A
136
−66.097
44.687
8.047
1.00
36.38
C


ATOM
1811
O
LYS
A
136
−65.399
43.914
7.388
1.00
36.24
O


ATOM
1813
N
ALA
A
137
−65.728
45.931
8.341
1.00
34.51
N


ATOM
1814
CA
ALA
A
137
−64.463
46.474
7.876
1.00
33.41
C


ATOM
1816
CB
ALA
A
137
−64.432
47.981
8.058
1.00
33.43
C


ATOM
1820
C
ALA
A
137
−63.291
45.827
8.600
1.00
32.30
C


ATOM
1821
O
ALA
A
137
−62.288
45.481
7.995
1.00
31.89
O


ATOM
1823
N
ILE
A
138
−63.437
45.662
9.905
1.00
31.41
N


ATOM
1824
CA
ILE
A
138
−62.395
45.074
10.737
1.00
30.60
C


ATOM
1826
CB
ILE
A
138
−62.770
45.131
12.238
1.00
30.20
C


ATOM
1828
CG1
ILE
A
138
−62.914
46.576
12.689
1.00
29.92
C


ATOM
1831
CD1
ILE
A
138
−61.681
47.414
12.417
1.00
30.50
C


ATOM
1835
CG2
ILE
A
138
−61.706
44.470
13.085
1.00
29.73
C


ATOM
1839
C
ILE
A
138
−62.140
43.631
10.320
1.00
30.34
C


ATOM
1840
O
ILE
A
138
−60.972
43.203
10.212
1.00
30.65
O


ATOM
1842
N
LEU
A
139
−63.227
42.884
10.098
1.00
29.69
N


ATOM
1843
CA
LEU
A
139
−63.134
41.523
9.562
1.00
29.23
C


ATOM
1845
CB
LEU
A
139
−64.517
40.917
9.332
1.00
28.92
C


ATOM
1848
CG
LEU
A
139
−65.066
40.185
10.545
1.00
29.06
C


ATOM
1850
CD1
LEU
A
139
−66.541
39.875
10.352
1.00
28.20
C


ATOM
1854
CD2
LEU
A
139
−64.250
38.922
10.813
1.00
28.59
C


ATOM
1858
C
LEU
A
139
−62.382
41.546
8.247
1.00
29.00
C


ATOM
1859
O
LEU
A
139
−61.444
40.773
8.035
1.00
29.50
O


ATOM
1861
N
SER
A
140
−62.790
42.458
7.372
1.00
28.14
N


ATOM
1862
CA
SER
A
140
−62.222
42.526
6.054
1.00
27.40
C


ATOM
1864
CB
SER
A
140
−62.912
43.619
5.260
1.00
27.35
C


ATOM
1867
OG
SER
A
140
−63.310
43.103
4.015
1.00
28.43
O


ATOM
1869
C
SER
A
140
−60.720
42.777
6.123
1.00
26.77
C


ATOM
1870
O
SER
A
140
−59.975
42.269
5.298
1.00
27.29
O


ATOM
1872
N
LEU
A
141
−60.285
43.563
7.105
1.00
25.89
N


ATOM
1873
CA
LEU
A
141
−58.872
43.897
7.283
1.00
25.20
C


ATOM
1875
CB
LEU
A
141
−58.717
45.164
8.155
1.00
25.00
C


ATOM
1878
CG
LEU
A
141
−57.298
45.670
8.489
1.00
24.35
C


ATOM
1880
CD1
LEU
A
141
−56.497
45.974
7.232
1.00
22.75
C


ATOM
1884
CD2
LEU
A
141
−57.329
46.893
9.385
1.00
22.81
C


ATOM
1888
C
LEU
A
141
−58.140
42.721
7.920
1.00
24.92
C


ATOM
1889
O
LEU
A
141
−57.034
42.380
7.521
1.00
24.77
O


ATOM
1891
N
TYR
A
142
−58.751
42.101
8.921
1.00
24.51
N


ATOM
1892
CA
TYR
A
142
−58.163
40.913
9.514
1.00
24.36
C


ATOM
1894
CB
TYR
A
142
−59.120
40.325
10.538
1.00
24.18
C


ATOM
1897
CG
TYR
A
142
−58.774
38.941
11.046
1.00
23.72
C


ATOM
1898
CD1
TYR
A
142
−57.878
38.763
12.091
1.00
22.97
C


ATOM
1900
CE1
TYR
A
142
−57.593
37.500
12.582
1.00
24.25
C


ATOM
1902
CZ
TYR
A
142
−58.229
36.386
12.030
1.00
25.75
C


ATOM
1903
OH
TYR
A
142
−57.967
35.100
12.500
1.00
26.97
O


ATOM
1905
CE2
TYR
A
142
−59.120
36.551
10.988
1.00
25.02
C


ATOM
1907
CD2
TYR
A
142
−59.390
37.820
10.511
1.00
24.01
C


ATOM
1909
C
TYR
A
142
−57.877
39.896
8.423
1.00
24.39
C


ATOM
1910
O
TYR
A
142
−56.822
39.276
8.380
1.00
24.19
O


ATOM
1912
N
GLU
A
143
−58.841
39.760
7.527
1.00
24.59
N


ATOM
1913
CA
GLU
A
143
−58.820
38.728
6.521
1.00
24.70
C


ATOM
1915
CB
GLU
A
143
−60.194
38.636
5.853
1.00
24.69
C


ATOM
1918
CG
GLU
A
143
−60.651
37.219
5.547
1.00
27.21
C


ATOM
1921
CD
GLU
A
143
−61.127
36.426
6.774
1.00
30.20
C


ATOM
1922
OE1
GLU
A
143
−60.261
35.776
7.393
1.00
33.40
O


ATOM
1923
OE2
GLU
A
143
−62.351
36.421
7.097
1.00
30.50
O


ATOM
1924
C
GLU
A
143
−57.701
39.010
5.518
1.00
24.08
C


ATOM
1925
O
GLU
A
143
−56.984
38.090
5.126
1.00
24.53
O


ATOM
1927
N
ALA
A
144
−57.537
40.281
5.147
1.00
23.30
N


ATOM
1928
CA
ALA
A
144
−56.515
40.715
4.173
1.00
22.79
C


ATOM
1930
CB
ALA
A
144
−56.787
42.154
3.740
1.00
22.49
C


ATOM
1934
C
ALA
A
144
−55.073
40.598
4.701
1.00
22.42
C


ATOM
1935
O
ALA
A
144
−54.128
40.380
3.935
1.00
22.36
O


ATOM
1937
N
SER
A
145
−54.909
40.713
6.012
1.00
21.80
N


ATOM
1938
CA
SER
A
145
−53.593
40.822
6.600
1.00
21.36
C


ATOM
1940
CB
SER
A
145
−53.726
41.170
8.066
1.00
21.21
C


ATOM
1943
OG
SER
A
145
−54.337
40.100
8.753
1.00
21.59
O


ATOM
1945
C
SER
A
145
−52.797
39.537
6.476
1.00
21.30
C


ATOM
1946
O
SER
A
145
−51.571
39.533
6.701
1.00
21.50
O


ATOM
1948
N
PHE
A
146
−53.488
38.439
6.154
1.00
21.00
N


ATOM
1949
CA
PHE
A
146
−52.827
37.127
6.030
1.00
20.41
C


ATOM
1951
CB
PHE
A
146
−53.796
35.979
6.338
1.00
20.20
C


ATOM
1954
CG
PHE
A
146
−54.130
35.873
7.798
1.00
19.91
C


ATOM
1955
CD1
PHE
A
146
−53.382
35.087
8.637
1.00
20.48
C


ATOM
1957
CE1
PHE
A
146
−53.679
35.012
9.992
1.00
20.59
C


ATOM
1959
CZ
PHE
A
146
−54.731
35.740
10.508
1.00
19.15
C


ATOM
1961
CE2
PHE
A
146
−55.464
36.536
9.691
1.00
19.10
C


ATOM
1963
CD2
PHE
A
146
−55.155
36.615
8.343
1.00
20.16
C


ATOM
1965
C
PHE
A
146
−52.174
36.964
4.680
1.00
19.76
C


ATOM
1966
O
PHE
A
146
−51.305
36.116
4.523
1.00
19.46
O


ATOM
1968
N
LEU
A
147
−52.550
37.819
3.729
1.00
19.34
N


ATOM
1969
CA
LEU
A
147
−51.933
37.804
2.402
1.00
19.13
C


ATOM
1971
CB
LEU
A
147
−52.905
38.367
1.347
1.00
18.67
C


ATOM
1974
CG
LEU
A
147
−53.964
37.334
.919
1.00
18.11
C


ATOM
1976
CD1
LEU
A
147
−55.090
37.248
1.961
1.00
15.10
C


ATOM
1980
CD2
LEU
A
147
−54.494
37.609
−.499
1.00
16.50
C


ATOM
1984
C
LEU
A
147
−50.582
38.525
2.369
1.00
19.10
C


ATOM
1985
O
LEU
A
147
−49.992
38.715
1.311
1.00
19.44
O


ATOM
1987
N
ALA
A
148
−50.075
38.882
3.542
1.00
19.13
N


ATOM
1988
CA
ALA
A
148
−48.967
39.806
3.664
1.00
18.84
C


ATOM
1990
CB
ALA
A
148
−48.762
40.167
5.117
1.00
18.78
C


ATOM
1994
C
ALA
A
148
−47.723
39.184
3.113
1.00
18.85
C


ATOM
1995
O
ALA
A
148
−47.548
37.975
3.206
1.00
18.80
O


ATOM
1997
N
LEU
A
149
−46.869
40.013
2.523
1.00
19.08
N


ATOM
1998
CA
LEU
A
149
−45.507
39.601
2.215
1.00
19.32
C


ATOM
2000
CB
LEU
A
149
−45.056
40.145
.863
1.00
19.14
C


ATOM
2003
CG
LEU
A
149
−45.819
39.650
−.364
1.00
19.16
C


ATOM
2005
CD1
LEU
A
149
−45.036
39.929
−1.645
1.00
18.43
C


ATOM
2009
CD2
LEU
A
149
−46.089
38.175
−.259
1.00
20.09
C


ATOM
2013
C
LEU
A
149
−44.527
40.029
3.304
1.00
19.60
C


ATOM
2014
O
LEU
A
149
−44.797
40.916
4.113
1.00
19.20
O


ATOM
2016
N
GLU
A
150
−43.384
39.361
3.309
1.00
20.42
N


ATOM
2017
CA
GLU
A
150
−42.286
39.674
4.215
1.00
21.03
C


ATOM
2019
CB
GLU
A
150
−41.098
38.741
3.948
1.00
21.03
C


ATOM
2022
CG
GLU
A
150
−40.491
38.176
5.205
1.00
22.23
C


ATOM
2025
CD
GLU
A
150
−39.433
37.117
4.941
1.00
24.34
C


ATOM
2026
OE1
GLU
A
150
−39.189
36.786
3.753
1.00
24.53
O


ATOM
2027
OE2
GLU
A
150
−38.843
36.625
5.940
1.00
25.82
O


ATOM
2028
C
GLU
A
150
−41.887
41.130
4.011
1.00
21.29
C


ATOM
2029
O
GLU
A
150
−41.619
41.544
2.885
1.00
21.13
O


ATOM
2031
N
GLY
A
151
−41.893
41.903
5.094
1.00
21.89
N


ATOM
2032
CA
GLY
A
151
−41.636
43.341
5.030
1.00
22.25
C


ATOM
2035
C
GLY
A
151
−42.871
44.221
5.152
1.00
22.67
C


ATOM
2036
O
GLY
A
151
−42.757
45.397
5.462
1.00
22.84
O


ATOM
2038
N
GLU
A
152
−44.055
43.669
4.918
1.00
23.19
N


ATOM
2039
CA
GLU
A
152
−45.263
44.474
4.937
1.00
23.76
C


ATOM
2041
CB
GLU
A
152
−46.350
43.813
4.100
1.00
23.79
C


ATOM
2044
CG
GLU
A
152
−46.037
43.890
2.615
1.00
23.98
C


ATOM
2047
CD
GLU
A
152
−47.147
43.368
1.749
1.00
23.72
C


ATOM
2048
OE1
GLU
A
152
−47.226
43.771
.574
1.00
22.11
O


ATOM
2049
OE2
GLU
A
152
−47.939
42.542
2.241
1.00
25.41
O


ATOM
2050
C
GLU
A
152
−45.722
44.719
6.365
1.00
24.47
C


ATOM
2051
O
GLU
A
152
−46.586
44.006
6.906
1.00
24.70
O


ATOM
2053
N
ASN
A
153
−45.134
45.744
6.969
1.00
25.00
N


ATOM
2054
CA
ASN
A
153
−45.287
45.978
8.404
1.00
25.59
C


ATOM
2056
CB
ASN
A
153
−44.221
46.957
8.902
1.00
25.55
C


ATOM
2059
CG
ASN
A
153
−44.386
48.331
8.308
1.00
25.57
C


ATOM
2060
OD1
ASN
A
153
−44.114
48.557
7.128
1.00
24.52
O


ATOM
2061
ND2
ASN
A
153
−44.867
49.256
9.117
1.00
27.05
N


ATOM
2064
C
ASN
A
153
−46.679
46.486
8.772
1.00
25.92
C


ATOM
2065
O
ASN
A
153
−47.172
46.238
9.872
1.00
26.02
O


ATOM
2067
N
ILE
A
154
−47.310
47.197
7.847
1.00
26.35
N


ATOM
2068
CA
ILE
A
154
−48.638
47.751
8.082
1.00
26.57
C


ATOM
2070
CB
ILE
A
154
−49.013
48.779
7.007
1.00
26.45
C


ATOM
2072
CG1
ILE
A
154
−48.159
50.023
7.164
1.00
26.36
C


ATOM
2075
CD1
ILE
A
154
−48.060
50.790
5.883
1.00
27.92
C


ATOM
2079
CG2
ILE
A
154
−50.467
49.152
7.089
1.00
26.25
C


ATOM
2083
C
ILE
A
154
−49.674
46.643
8.111
1.00
26.96
C


ATOM
2084
O
ILE
A
154
−50.650
46.741
8.851
1.00
27.12
O


ATOM
2086
N
LEU
A
155
−49.467
45.588
7.320
1.00
27.35
N


ATOM
2087
CA
LEU
A
155
−50.422
44.475
7.304
1.00
27.76
C


ATOM
2089
CB
LEU
A
155
−50.238
43.594
6.067
1.00
27.73
C


ATOM
2092
CG
LEU
A
155
−51.090
43.990
4.875
1.00
27.31
C


ATOM
2094
CD1
LEU
A
155
−50.980
45.456
4.683
1.00
28.13
C


ATOM
2098
CD2
LEU
A
155
−50.633
43.262
3.623
1.00
27.79
C


ATOM
2102
C
LEU
A
155
−50.340
43.642
8.582
1.00
28.22
C


ATOM
2103
O
LEU
A
155
−51.361
43.237
9.112
1.00
27.95
O


ATOM
2105
N
ASP
A
156
−49.128
43.395
9.068
1.00
28.95
N


ATOM
2106
CA
ASP
A
156
−48.944
42.723
10.348
1.00
29.71
C


ATOM
2108
CB
ASP
A
156
−47.450
42.461
10.639
1.00
30.23
C


ATOM
2111
CG
ASP
A
156
−46.938
41.125
10.027
1.00
32.82
C


ATOM
2112
OD1
ASP
A
156
−47.765
40.240
9.658
1.00
36.27
O


ATOM
2113
OD2
ASP
A
156
−45.700
40.961
9.923
1.00
34.48
O


ATOM
2114
C
ASP
A
156
−49.570
43.539
11.469
1.00
29.66
C


ATOM
2115
O
ASP
A
156
−50.109
42.969
12.425
1.00
29.81
O


ATOM
2117
N
GLU
A
157
−49.514
44.866
11.345
1.00
29.69
N


ATOM
2118
CA
GLU
A
157
−50.129
45.768
12.329
1.00
29.57
C


ATOM
2120
CB
GLU
A
157
−49.581
47.186
12.178
1.00
29.71
C


ATOM
2123
CG
GLU
A
157
−48.164
47.326
12.712
1.00
30.53
C


ATOM
2126
CD
GLU
A
157
−47.455
48.544
12.169
1.00
31.96
C


ATOM
2127
OE1
GLU
A
157
−48.167
49.491
11.741
1.00
33.56
O


ATOM
2128
OE2
GLU
A
157
−46.195
48.546
12.166
1.00
31.54
O


ATOM
2129
C
GLU
A
157
−51.649
45.771
12.230
1.00
29.16
C


ATOM
2130
O
GLU
A
157
−52.330
45.819
13.241
1.00
29.00
O


ATOM
2132
N
ALA
A
158
−52.172
45.716
11.010
1.00
28.86
N


ATOM
2133
CA
ALA
A
158
−53.606
45.570
10.792
1.00
28.79
C


ATOM
2135
CB
ALA
A
158
−53.893
45.456
9.301
1.00
28.44
C


ATOM
2139
C
ALA
A
158
−54.171
44.352
11.536
1.00
28.93
C


ATOM
2140
O
ALA
A
158
−55.265
44.402
12.098
1.00
28.77
O


ATOM
2142
N
LYS
A
159
−53.416
43.260
11.528
1.00
29.19
N


ATOM
2143
CA
LYS
A
159
−53.849
42.022
12.143
1.00
29.57
C


ATOM
2145
CB
LYS
A
159
−52.929
40.880
11.710
1.00
29.62
C


ATOM
2148
CG
LYS
A
159
−53.297
39.513
12.258
1.00
30.27
C


ATOM
2151
CD
LYS
A
159
−52.765
38.365
11.387
1.00
31.78
C


ATOM
2154
CE
LYS
A
159
−51.259
38.132
11.525
1.00
33.15
C


ATOM
2157
NZ
LYS
A
159
−50.911
36.696
11.248
1.00
33.88
N


ATOM
2161
C
LYS
A
159
−53.866
42.160
13.670
1.00
29.99
C


ATOM
2162
O
LYS
A
159
−54.767
41.642
14.332
1.00
30.29
O


ATOM
2164
N
VAL
A
160
−52.886
42.862
14.236
1.00
30.07
N


ATOM
2165
CA
VAL
A
160
−52.840
43.047
15.696
1.00
30.03
C


ATOM
2167
CB
VAL
A
160
−51.520
43.691
16.162
1.00
29.88
C


ATOM
2169
CG1
VAL
A
160
−51.515
43.863
17.671
1.00
28.94
C


ATOM
2173
CG2
VAL
A
160
−50.341
42.848
15.707
1.00
30.23
C


ATOM
2177
C
VAL
A
160
−53.996
43.925
16.149
1.00
30.05
C


ATOM
2178
O
VAL
A
160
−54.544
43.752
17.234
1.00
30.31
O


ATOM
2180
N
PHE
A
161
−54.355
44.862
15.290
1.00
30.08
N


ATOM
2181
CA
PHE
A
161
−55.407
45.808
15.558
1.00
30.09
C


ATOM
2183
CB
PHE
A
161
−55.255
46.993
14.598
1.00
29.92
C


ATOM
2186
CG
PHE
A
161
−56.370
47.974
14.654
1.00
28.52
C


ATOM
2187
CD1
PHE
A
161
−56.347
49.005
15.554
1.00
27.92
C


ATOM
2189
CE1
PHE
A
161
−57.361
49.903
15.600
1.00
28.06
C


ATOM
2191
CZ
PHE
A
161
−58.411
49.783
14.733
1.00
28.76
C


ATOM
2193
CE2
PHE
A
161
−58.441
48.757
13.826
1.00
28.31
C


ATOM
2195
CD2
PHE
A
161
−57.429
47.869
13.789
1.00
28.16
C


ATOM
2197
C
PHE
A
161
−56.746
45.123
15.388
1.00
30.55
C


ATOM
2198
O
PHE
A
161
−57.598
45.203
16.258
1.00
30.53
O


ATOM
2200
N
ALA
A
162
−56.930
44.438
14.271
1.00
31.34
N


ATOM
2201
CA
ALA
A
162
−58.193
43.770
14.023
1.00
32.26
C


ATOM
2203
CB
ALA
A
162
−58.217
43.139
12.643
1.00
32.31
C


ATOM
2207
C
ALA
A
162
−58.500
42.734
15.118
1.00
33.09
C


ATOM
2208
O
ALA
A
162
−59.557
42.814
15.735
1.00
33.83
O


ATOM
2210
N
ILE
A
163
−57.587
41.799
15.393
1.00
33.59
N


ATOM
2211
CA
ILE
A
163
−57.826
40.799
16.438
1.00
34.02
C


ATOM
2213
CB
ILE
A
163
−56.597
39.907
16.745
1.00
33.98
C


ATOM
2215
CG1
ILE
A
163
−56.235
39.008
15.566
1.00
34.37
C


ATOM
2218
CD1
ILE
A
163
−54.878
38.317
15.722
1.00
34.38
C


ATOM
2222
CG2
ILE
A
163
−56.883
38.995
17.919
1.00
33.38
C


ATOM
2226
C
ILE
A
163
−58.225
41.472
17.744
1.00
34.75
C


ATOM
2227
O
ILE
A
163
−59.189
41.064
18.373
1.00
35.03
O


ATOM
2229
N
SER
A
164
−57.501
42.504
18.156
1.00
35.76
N


ATOM
2230
CA
SER
A
164
−57.763
43.117
19.463
1.00
36.59
C


ATOM
2232
CB
SER
A
164
−56.828
44.293
19.735
1.00
36.59
C


ATOM
2235
OG
SER
A
164
−57.350
45.485
19.164
1.00
36.46
O


ATOM
2237
C
SER
A
164
−59.196
43.611
19.556
1.00
37.42
C


ATOM
2238
O
SER
A
164
−59.860
43.420
20.571
1.00
37.38
O


ATOM
2240
N
HIS
A
165
−59.661
44.251
18.486
1.00
38.51
N


ATOM
2241
CA
HIS
A
165
−60.990
44.851
18.467
1.00
39.40
C


ATOM
2243
CB
HIS
A
165
−61.008
46.097
17.574
1.00
39.76
C


ATOM
2246
CG
HIS
A
165
−60.467
47.323
18.251
1.00
42.06
C


ATOM
2247
ND1
HIS
A
165
−59.205
47.821
18.000
1.00
44.21
N


ATOM
2249
CE1
HIS
A
165
−58.998
48.893
18.748
1.00
45.04
C


ATOM
2251
NE2
HIS
A
165
−60.080
49.106
19.478
1.00
44.99
N


ATOM
2253
CD2
HIS
A
165
−61.011
48.135
19.192
1.00
43.76
C


ATOM
2255
C
HIS
A
165
−62.078
43.872
18.060
1.00
39.38
C


ATOM
2256
O
HIS
A
165
−63.248
44.244
18.067
1.00
39.43
O


ATOM
2258
N
LEU
A
166
−61.683
42.632
17.745
1.00
39.54
N


ATOM
2259
CA
LEU
A
166
−62.589
41.550
17.326
1.00
39.55
C


ATOM
2261
CB
LEU
A
166
−62.001
40.766
16.154
1.00
39.28
C


ATOM
2264
CG
LEU
A
166
−62.156
41.339
14.752
1.00
38.23
C


ATOM
2266
CD1
LEU
A
166
−61.361
40.501
13.805
1.00
37.53
C


ATOM
2270
CD2
LEU
A
166
−63.594
41.367
14.332
1.00
37.21
C


ATOM
2274
C
LEU
A
166
−62.842
40.555
18.438
1.00
40.08
C


ATOM
2275
O
LEU
A
166
−63.991
40.220
18.733
1.00
40.42
O


ATOM
2277
N
LYS
A
167
−61.766
40.074
19.052
1.00
40.58
N


ATOM
2278
CA
LYS
A
167
−61.875
39.090
20.133
1.00
41.09
C


ATOM
2280
CB
LYS
A
167
−60.491
38.632
20.595
1.00
41.13
C


ATOM
2283
CG
LYS
A
167
−59.897
39.399
21.768
1.00
42.16
C


ATOM
2286
CD
LYS
A
167
−58.421
39.035
22.013
1.00
44.45
C


ATOM
2289
CE
LYS
A
167
−58.070
37.561
21.654
1.00
45.56
C


ATOM
2292
NZ
LYS
A
167
−56.610
37.237
21.798
1.00
46.20
N


ATOM
2296
C
LYS
A
167
−62.678
39.584
21.337
1.00
41.23
C


ATOM
2297
O
LYS
A
167
−62.994
38.793
22.215
1.00
41.47
O


ATOM
2299
N
GLU
A
168
−62.995
40.884
21.352
1.00
41.49
N


ATOM
2300
CA
GLU
A
168
−63.704
41.583
22.437
1.00
41.42
C


ATOM
2302
CB
GLU
A
168
−65.201
41.730
22.100
1.00
41.27
C


ATOM
2305
CG
GLU
A
168
−65.995
40.424
22.016
1.00
41.01
C


ATOM
2308
CD
GLU
A
168
−66.928
40.328
20.787
1.00
40.84
C


ATOM
2309
OE1
GLU
A
168
−66.701
41.040
19.770
1.00
39.82
O


ATOM
2310
OE2
GLU
A
168
−67.884
39.509
20.845
1.00
39.04
O


ATOM
2311
C
GLU
A
168
−63.484
41.004
23.843
1.00
41.66
C


ATOM
2312
O
GLU
A
168
−62.435
41.231
24.469
1.00
41.46
O


ATOM
2314
N
GLU
A
172
−71.668
38.961
21.192
1.00
55.65
N


ATOM
2315
CA
GLU
A
172
−73.052
39.153
20.721
1.00
56.00
C


ATOM
2317
CB
GLU
A
172
−73.876
37.880
20.937
1.00
56.27
C


ATOM
2320
CG
GLU
A
172
−73.198
36.620
20.390
1.00
57.12
C


ATOM
2323
CD
GLU
A
172
−74.056
35.363
20.516
1.00
58.18
C


ATOM
2324
OE1
GLU
A
172
−75.300
35.480
20.622
1.00
58.84
O


ATOM
2325
OE2
GLU
A
172
−73.480
34.249
20.498
1.00
58.98
O


ATOM
2326
C
GLU
A
172
−73.766
40.386
21.334
1.00
55.70
C


ATOM
2327
O
GLU
A
172
−74.956
40.347
21.688
1.00
54.95
O


ATOM
2329
N
LYS
A
173
−72.987
41.458
21.486
1.00
55.58
N


ATOM
2330
CA
LYS
A
173
−73.496
42.831
21.466
1.00
55.43
C


ATOM
2332
CB
LYS
A
173
−72.649
43.741
22.357
1.00
55.51
C


ATOM
2335
CG
LYS
A
173
−72.527
43.223
23.793
1.00
56.07
C


ATOM
2338
CD
LYS
A
173
−72.803
44.291
24.868
1.00
55.87
C


ATOM
2341
CE
LYS
A
173
−73.111
43.642
26.221
1.00
55.20
C


ATOM
2344
NZ
LYS
A
173
−72.893
44.576
27.348
1.00
54.63
N


ATOM
2348
C
LYS
A
173
−73.449
43.297
20.009
1.00
55.01
C


ATOM
2349
O
LYS
A
173
−74.091
44.274
19.625
1.00
54.97
O


ATOM
2351
N
ILE
A
174
−72.647
42.581
19.223
1.00
54.57
N


ATOM
2352
CA
ILE
A
174
−72.713
42.550
17.767
1.00
54.22
C


ATOM
2354
CB
ILE
A
174
−71.429
41.845
17.227
1.00
54.21
C


ATOM
2356
CG1
ILE
A
174
−70.196
42.724
17.474
1.00
54.73
C


ATOM
2359
CD1
ILE
A
174
−68.858
41.949
17.553
1.00
55.78
C


ATOM
2363
CG2
ILE
A
174
−71.532
41.504
15.759
1.00
54.06
C


ATOM
2367
C
ILE
A
174
−73.957
41.744
17.384
1.00
53.88
C


ATOM
2368
O
ILE
A
174
−74.587
41.134
18.250
1.00
53.83
O


ATOM
2370
N
GLY
A
175
−74.332
41.747
16.107
1.00
53.59
N


ATOM
2371
CA
GLY
A
175
−75.351
40.817
15.613
1.00
53.51
C


ATOM
2374
C
GLY
A
175
−75.130
39.395
16.126
1.00
53.43
C


ATOM
2375
O
GLY
A
175
−74.119
39.105
16.760
1.00
53.80
O


ATOM
2377
N
LYS
A
176
−76.070
38.495
15.861
1.00
53.10
N


ATOM
2378
CA
LYS
A
176
−75.926
37.098
16.286
1.00
52.68
C


ATOM
2380
CB
LYS
A
176
−77.291
36.522
16.677
1.00
52.99
C


ATOM
2383
CG
LYS
A
176
−78.003
37.387
17.746
1.00
54.12
C


ATOM
2386
CD
LYS
A
176
−79.201
36.697
18.436
1.00
54.57
C


ATOM
2389
CE
LYS
A
176
−79.503
37.369
19.792
1.00
54.79
C


ATOM
2392
NZ
LYS
A
176
−80.458
36.598
20.653
1.00
55.20
N


ATOM
2396
C
LYS
A
176
−75.246
36.267
15.196
1.00
51.83
C


ATOM
2397
O
LYS
A
176
−74.393
35.433
15.486
1.00
51.69
O


ATOM
2399
N
GLU
A
177
−75.609
36.520
13.940
1.00
50.90
N


ATOM
2400
CA
GLU
A
177
−74.975
35.854
12.800
1.00
50.19
C


ATOM
2402
CB
GLU
A
177
−75.792
36.062
11.507
1.00
50.41
C


ATOM
2405
CG
GLU
A
177
−75.506
37.368
10.735
1.00
51.03
C


ATOM
2408
CD
GLU
A
177
−76.403
37.572
9.507
1.00
52.17
C


ATOM
2409
OE1
GLU
A
177
−75.955
38.276
8.569
1.00
52.63
O


ATOM
2410
OE2
GLU
A
177
−77.546
37.048
9.479
1.00
52.03
O


ATOM
2411
C
GLU
A
177
−73.549
36.369
12.607
1.00
49.10
C


ATOM
2412
O
GLU
A
177
−72.626
35.597
12.321
1.00
49.53
O


ATOM
2414
N
LEU
A
178
−73.388
37.681
12.770
1.00
47.39
N


ATOM
2415
CA
LEU
A
178
−72.110
38.371
12.575
1.00
45.63
C


ATOM
2417
CB
LEU
A
178
−72.352
39.877
12.615
1.00
45.59
C


ATOM
2420
CG
LEU
A
178
−71.280
40.809
12.085
1.00
45.45
C


ATOM
2422
CD1
LEU
A
178
−70.969
40.515
10.620
1.00
45.45
C


ATOM
2426
CD2
LEU
A
178
−71.765
42.233
12.279
1.00
44.63
C


ATOM
2430
C
LEU
A
178
−71.095
37.979
13.634
1.00
44.06
C


ATOM
2431
O
LEU
A
178
−69.902
38.012
13.387
1.00
43.70
O


ATOM
2433
N
ALA
A
179
−71.586
37.611
14.810
1.00
42.54
N


ATOM
2434
CA
ALA
A
179
−70.753
37.041
15.847
1.00
41.66
C


ATOM
2436
CB
ALA
A
179
−71.545
36.884
17.122
1.00
41.69
C


ATOM
2440
C
ALA
A
179
−70.193
35.695
15.416
1.00
40.75
C


ATOM
2441
O
ALA
A
179
−69.078
35.351
15.769
1.00
40.61
O


ATOM
2443
N
GLU
A
180
−70.974
34.931
14.664
1.00
39.88
N


ATOM
2444
CA
GLU
A
180
−70.518
33.639
14.143
1.00
39.40
C


ATOM
2446
CB
GLU
A
180
−71.710
32.781
13.718
1.00
39.74
C


ATOM
2449
CG
GLU
A
180
−72.650
32.415
14.865
1.00
40.88
C


ATOM
2452
CD
GLU
A
180
−73.913
31.710
14.398
1.00
42.02
C


ATOM
2453
OE1
GLU
A
180
−74.380
32.022
13.271
1.00
43.05
O


ATOM
2454
OE2
GLU
A
180
−74.437
30.857
15.166
1.00
41.93
O


ATOM
2455
C
GLU
A
180
−69.565
33.805
12.960
1.00
38.29
C


ATOM
2456
O
GLU
A
180
−68.739
32.940
12.699
1.00
38.23
O


ATOM
2458
N
GLN
A
181
−69.704
34.911
12.240
1.00
36.92
N


ATOM
2459
CA
GLN
A
181
−68.748
35.299
11.223
1.00
35.74
C


ATOM
2461
CB
GLN
A
181
−69.272
36.516
10.463
1.00
35.94
C


ATOM
2464
CG
GLN
A
181
−68.931
36.537
8.975
1.00
36.93
C


ATOM
2467
CD
GLN
A
181
−69.693
35.492
8.176
1.00
37.72
C


ATOM
2468
OE1
GLN
A
181
−70.769
35.067
8.567
1.00
38.78
O


ATOM
2469
NE2
GLN
A
181
−69.139
35.083
7.050
1.00
38.11
N


ATOM
2472
C
GLN
A
181
−67.406
35.632
11.881
1.00
34.64
C


ATOM
2473
O
GLN
A
181
−66.348
35.411
11.294
1.00
34.73
O


ATOM
2475
N
VAL
A
182
−67.448
36.158
13.102
1.00
33.29
N


ATOM
2476
CA
VAL
A
182
−66.224
36.488
13.842
1.00
32.28
C


ATOM
2478
CB
VAL
A
182
−66.433
37.653
14.855
1.00
32.10
C


ATOM
2480
CG1
VAL
A
182
−66.328
38.991
14.166
1.00
31.51
C


ATOM
2484
CG2
VAL
A
182
−65.420
37.594
15.957
1.00
31.69
C


ATOM
2488
C
VAL
A
182
−65.613
35.298
14.575
1.00
31.49
C


ATOM
2489
O
VAL
A
182
−64.396
35.230
14.668
1.00
31.43
O


ATOM
2491
N
SER
A
183
−66.422
34.378
15.106
1.00
30.56
N


ATOM
2492
CA
SER
A
183
−65.860
33.174
15.744
1.00
30.16
C


ATOM
2494
CB
SER
A
183
−66.926
32.253
16.327
1.00
30.29
C


ATOM
2497
OG
SER
A
183
−67.796
32.934
17.214
1.00
32.35
O


ATOM
2499
C
SER
A
183
−65.111
32.403
14.692
1.00
29.30
C


ATOM
2500
O
SER
A
183
−63.974
31.981
14.903
1.00
29.32
O


ATOM
2502
N
HIS
A
184
−65.768
32.252
13.546
1.00
28.24
N


ATOM
2503
CA
HIS
A
184
−65.215
31.578
12.379
1.00
27.36
C


ATOM
2505
CB
HIS
A
184
−66.245
31.653
11.254
1.00
27.41
C


ATOM
2508
CG
HIS
A
184
−65.930
30.807
10.064
1.00
26.90
C


ATOM
2509
ND1
HIS
A
184
−65.484
29.511
10.166
1.00
27.76
N


ATOM
2511
CE1
HIS
A
184
−65.321
29.009
8.955
1.00
27.47
C


ATOM
2513
NE2
HIS
A
184
−65.661
29.929
8.075
1.00
26.52
N


ATOM
2515
CD2
HIS
A
184
−66.059
31.058
8.742
1.00
26.61
C


ATOM
2517
C
HIS
A
184
−63.898
32.200
11.940
1.00
26.69
C


ATOM
2518
O
HIS
A
184
−62.881
31.525
11.862
1.00
26.44
O


ATOM
2520
N
ALA
A
185
−63.909
33.498
11.675
1.00
26.11
N


ATOM
2521
CA
ALA
A
185
−62.711
34.176
11.205
1.00
25.63
C


ATOM
2523
CB
ALA
A
185
−62.970
35.627
11.109
1.00
25.74
C


ATOM
2527
C
ALA
A
185
−61.552
33.917
12.153
1.00
25.33
C


ATOM
2528
O
ALA
A
185
−60.451
33.572
11.725
1.00
25.79
O


ATOM
2530
N
LEU
A
186
−61.814
34.066
13.450
1.00
24.77
N


ATOM
2531
CA
LEU
A
186
−60.776
33.940
14.470
1.00
24.05
C


ATOM
2533
CB
LEU
A
186
−61.256
34.498
15.814
1.00
23.63
C


ATOM
2536
CG
LEU
A
186
−61.516
36.012
15.903
1.00
22.51
C


ATOM
2538
CD1
LEU
A
186
−62.057
36.399
17.266
1.00
20.79
C


ATOM
2542
CD2
LEU
A
186
−60.273
36.793
15.613
1.00
21.13
C


ATOM
2546
C
LEU
A
186
−60.316
32.497
14.613
1.00
24.02
C


ATOM
2547
O
LEU
A
186
−59.169
32.250
14.943
1.00
24.27
O


ATOM
2549
N
GLU
A
187
−61.201
31.543
14.347
1.00
23.88
N


ATOM
2550
CA
GLU
A
187
−60.836
30.117
14.348
1.00
23.53
C


ATOM
2552
CB
GLU
A
187
−62.029
29.270
13.919
1.00
23.66
C


ATOM
2555
CG
GLU
A
187
−61.945
27.828
14.316
1.00
25.26
C


ATOM
2558
CD
GLU
A
187
−63.049
26.971
13.693
1.00
28.04
C


ATOM
2559
OE1
GLU
A
187
−63.672
27.393
12.681
1.00
28.67
O


ATOM
2560
OE2
GLU
A
187
−63.288
25.858
14.225
1.00
29.72
O


ATOM
2561
C
GLU
A
187
−59.686
29.838
13.395
1.00
22.92
C


ATOM
2562
O
GLU
A
187
−58.765
29.091
13.729
1.00
22.53
O


ATOM
2564
N
LEU
A
188
−59.763
30.446
12.209
1.00
22.46
N


ATOM
2565
CA
LEU
A
188
−58.799
30.246
11.121
1.00
22.07
C


ATOM
2567
CB
LEU
A
188
−58.802
28.794
10.635
1.00
22.11
C


ATOM
2570
CG
LEU
A
188
−57.876
28.362
9.493
1.00
22.17
C


ATOM
2572
CD1
LEU
A
188
−56.456
28.051
9.961
1.00
21.62
C


ATOM
2576
CD2
LEU
A
188
−58.464
27.134
8.822
1.00
22.40
C


ATOM
2580
C
LEU
A
188
−59.237
31.137
9.985
1.00
21.69
C


ATOM
2581
O
LEU
A
188
−60.380
31.075
9.563
1.00
21.53
O


ATOM
2583
N
PRO
A
189
−58.333
31.973
9.474
1.00
21.46
N


ATOM
2584
CA
PRO
A
189
−58.745
32.935
8.472
1.00
21.18
C


ATOM
2586
CB
PRO
A
189
−57.592
33.936
8.486
1.00
21.03
C


ATOM
2589
CG
PRO
A
189
−56.423
33.118
8.757
1.00
21.21
C


ATOM
2592
CD
PRO
A
189
−56.873
31.992
9.668
1.00
21.61
C


ATOM
2595
C
PRO
A
189
−58.946
32.314
7.076
1.00
20.96
C


ATOM
2596
O
PRO
A
189
−58.418
31.247
6.793
1.00
21.02
O


ATOM
2597
N
LEU
A
190
−59.714
32.994
6.226
1.00
20.89
N


ATOM
2598
CA
LEU
A
190
−60.018
32.533
4.867
1.00
20.74
C


ATOM
2600
CB
LEU
A
190
−60.597
33.690
4.053
1.00
20.76
C


ATOM
2603
CG
LEU
A
190
−62.090
33.924
4.259
1.00
21.35
C


ATOM
2605
CD1
LEU
A
190
−62.537
35.196
3.578
1.00
20.54
C


ATOM
2609
CD2
LEU
A
190
−62.889
32.712
3.720
1.00
23.39
C


ATOM
2613
C
LEU
A
190
−58.814
31.971
4.112
1.00
20.35
C


ATOM
2614
O
LEU
A
190
−58.859
30.871
3.546
1.00
20.08
O


ATOM
2616
N
HIS
A
191
−57.734
32.746
4.132
1.00
19.81
N


ATOM
2617
CA
HIS
A
191
−56.537
32.448
3.364
1.00
18.89
C


ATOM
2619
CB
HIS
A
191
−55.548
33.592
3.536
1.00
18.92
C


ATOM
2622
CG
HIS
A
191
−54.372
33.520
2.623
1.00
18.51
C


ATOM
2623
ND1
HIS
A
191
−54.482
33.647
1.258
1.00
18.08
N


ATOM
2625
CE1
HIS
A
191
−53.281
33.544
.718
1.00
18.96
C


ATOM
2627
NE2
HIS
A
191
−52.397
33.371
1.684
1.00
17.01
N


ATOM
2629
CD2
HIS
A
191
−53.054
33.355
2.884
1.00
17.94
C


ATOM
2631
C
HIS
A
191
−55.889
31.142
3.759
1.00
18.32
C


ATOM
2632
O
HIS
A
191
−55.217
30.531
2.942
1.00
17.98
O


ATOM
2634
N
ARG
A
192
−56.093
30.719
5.006
1.00
18.06
N


ATOM
2635
CA
ARG
A
192
−55.502
29.480
5.523
1.00
17.99
C


ATOM
2637
CB
ARG
A
192
−54.940
29.722
6.909
1.00
17.77
C


ATOM
2640
CG
ARG
A
192
−53.822
30.683
6.881
1.00
18.47
C


ATOM
2643
CD
ARG
A
192
−53.082
30.748
8.196
1.00
19.80
C


ATOM
2646
NE
ARG
A
192
−52.174
31.900
8.224
1.00
20.33
N


ATOM
2648
CZ
ARG
A
192
−51.176
32.048
9.077
1.00
20.10
C


ATOM
2649
NH1
ARG
A
192
−50.928
31.113
9.972
1.00
21.72
N


ATOM
2652
NH2
ARG
A
192
−50.407
33.119
9.019
1.00
20.79
N


ATOM
2655
C
ARG
A
192
−56.477
28.311
5.590
1.00
18.00
C


ATOM
2656
O
ARG
A
192
−56.067
27.170
5.871
1.00
18.21
O


ATOM
2658
N
ARG
A
193
−57.758
28.588
5.335
1.00
17.59
N


ATOM
2659
CA
ARG
A
193
−58.779
27.563
5.382
1.00
17.16
C


ATOM
2661
CB
ARG
A
193
−60.141
28.164
5.741
1.00
17.45
C


ATOM
2664
CG
ARG
A
193
−61.109
27.132
6.322
1.00
18.70
C


ATOM
2667
CD
ARG
A
193
−62.479
27.682
6.686
1.00
20.20
C


ATOM
2670
NE
ARG
A
193
−62.423
28.682
7.751
1.00
22.59
N


ATOM
2672
CZ
ARG
A
193
−62.386
28.435
9.067
1.00
24.12
C


ATOM
2673
NH1
ARG
A
193
−62.395
27.198
9.575
1.00
22.66
N


ATOM
2676
NH2
ARG
A
193
−62.348
29.469
9.898
1.00
26.36
N


ATOM
2679
C
ARG
A
193
−58.871
26.842
4.058
1.00
16.63
C


ATOM
2680
O
ARG
A
193
−58.861
27.461
3.005
1.00
15.93
O


ATOM
2682
N
THR
A
194
−58.955
25.518
4.149
1.00
16.72
N


ATOM
2683
CA
THR
A
194
−59.332
24.638
3.051
1.00
16.88
C


ATOM
2685
CB
THR
A
194
−59.520
23.250
3.592
1.00
16.43
C


ATOM
2687
OG1
THR
A
194
−58.252
22.605
3.583
1.00
17.74
O


ATOM
2689
CG2
THR
A
194
−60.454
22.441
2.754
1.00
18.43
C


ATOM
2693
C
THR
A
194
−60.607
25.112
2.384
1.00
17.28
C


ATOM
2694
O
THR
A
194
−61.441
25.734
3.022
1.00
17.44
O


ATOM
2696
N
GLN
A
195
−60.765
24.855
1.091
1.00
18.05
N


ATOM
2697
CA
GLN
A
195
−61.925
25.402
.397
1.00
18.76
C


ATOM
2699
CB
GLN
A
195
−61.768
25.381
−1.114
1.00
18.87
C


ATOM
2702
CG
GLN
A
195
−63.145
25.523
−1.761
1.00
20.75
C


ATOM
2705
CD
GLN
A
195
−63.095
25.922
−3.179
1.00
23.41
C


ATOM
2706
OE1
GLN
A
195
−62.031
26.088
−3.733
1.00
27.07
O


ATOM
2707
NE2
GLN
A
195
−64.248
26.090
−3.791
1.00
25.02
N


ATOM
2710
C
GLN
A
195
−63.243
24.704
.765
1.00
18.93
C


ATOM
2711
O
GLN
A
195
−64.169
25.333
1.291
1.00
19.42
O


ATOM
2713
N
ARG
A
196
−63.345
23.418
.443
1.00
18.90
N


ATOM
2714
CA
ARG
A
196
−64.577
22.685
.663
1.00
18.68
C


ATOM
2716
CB
ARG
A
196
−64.356
21.186
.454
1.00
18.53
C


ATOM
2719
CG
ARG
A
196
−64.851
20.644
−.888
1.00
18.31
C


ATOM
2722
CD
ARG
A
196
−64.705
21.622
−2.037
1.00
17.93
C


ATOM
2725
NE
ARG
A
196
−65.930
21.720
−2.834
1.00
18.52
N


ATOM
2727
CZ
ARG
A
196
−66.480
22.857
−3.256
1.00
18.63
C


ATOM
2728
NH1
ARG
A
196
−65.938
24.014
−2.937
1.00
19.84
N


ATOM
2731
NH2
ARG
A
196
−67.582
22.844
−3.999
1.00
18.53
N


ATOM
2734
C
ARG
A
196
−65.070
22.982
2.061
1.00
19.02
C


ATOM
2735
O
ARG
A
196
−66.276
23.085
2.284
1.00
19.30
O


ATOM
2737
N
LEU
A
197
−64.127
23.152
2.990
1.00
19.09
N


ATOM
2738
CA
LEU
A
197
−64.444
23.432
4.379
1.00
19.19
C


ATOM
2740
CB
LEU
A
197
−63.203
23.346
5.262
1.00
19.14
C


ATOM
2743
CG
LEU
A
197
−63.135
22.097
6.130
1.00
19.99
C


ATOM
2745
CD1
LEU
A
197
−64.476
21.899
6.811
1.00
21.56
C


ATOM
2749
CD2
LEU
A
197
−62.016
22.198
7.161
1.00
20.06
C


ATOM
2753
C
LEU
A
197
−65.071
24.781
4.553
1.00
19.52
C


ATOM
2754
O
LEU
A
197
−66.052
24.902
5.252
1.00
19.85
O


ATOM
2756
N
GLU
A
198
−64.488
25.803
3.941
1.00
20.11
N


ATOM
2757
CA
GLU
A
198
−65.051
27.147
3.986
1.00
20.47
C


ATOM
2759
CB
GLU
A
198
−64.079
28.156
3.385
1.00
20.84
C


ATOM
2762
CG
GLU
A
198
−64.659
29.539
3.069
1.00
22.30
C


ATOM
2765
CD
GLU
A
198
−65.206
30.260
4.283
1.00
24.40
C


ATOM
2766
OE1
GLU
A
198
−64.852
29.894
5.418
1.00
25.34
O


ATOM
2767
OE2
GLU
A
198
−65.991
31.217
4.106
1.00
26.83
O


ATOM
2768
C
GLU
A
198
−66.360
27.186
3.226
1.00
20.57
C


ATOM
2769
O
GLU
A
198
−67.212
28.009
3.529
1.00
20.65
O


ATOM
2771
N
ALA
A
199
−66.519
26.298
2.240
1.00
20.76
N


ATOM
2772
CA
ALA
A
199
−67.751
26.229
1.452
1.00
20.52
C


ATOM
2774
CB
ALA
A
199
−67.521
25.492
.166
1.00
20.44
C


ATOM
2778
C
ALA
A
199
−68.907
25.611
2.232
1.00
20.55
C


ATOM
2779
O
ALA
A
199
−69.988
26.158
2.202
1.00
20.17
O


ATOM
2781
N
VAL
A
200
−68.701
24.493
2.933
1.00
21.10
N


ATOM
2782
CA
VAL
A
200
−69.791
23.935
3.774
1.00
21.51
C


ATOM
2784
CB
VAL
A
200
−69.509
22.576
4.485
1.00
21.18
C


ATOM
2786
CG1
VAL
A
200
−69.618
21.460
3.525
1.00
21.27
C


ATOM
2790
CG2
VAL
A
200
−68.161
22.569
5.200
1.00
21.23
C


ATOM
2794
C
VAL
A
200
−70.170
24.905
4.860
1.00
21.99
C


ATOM
2795
O
VAL
A
200
−71.338
25.022
5.186
1.00
22.99
O


ATOM
2797
N
TRP
A
201
−69.204
25.590
5.440
1.00
22.10
N


ATOM
2798
CA
TRP
A
201
−69.551
26.565
6.433
1.00
22.58
C


ATOM
2800
CB
TRP
A
201
−68.315
27.144
7.121
1.00
22.92
C


ATOM
2803
CG
TRP
A
201
−68.667
27.957
8.310
1.00
23.65
C


ATOM
2804
CD1
TRP
A
201
−68.758
27.520
9.588
1.00
25.08
C


ATOM
2806
NE1
TRP
A
201
−69.127
28.549
10.417
1.00
26.35
N


ATOM
2808
CE2
TRP
A
201
−69.290
29.683
9.669
1.00
25.48
C


ATOM
2809
CD2
TRP
A
201
−69.010
29.344
8.332
1.00
24.77
C


ATOM
2810
CE3
TRP
A
201
−69.095
30.336
7.355
1.00
24.92
C


ATOM
2812
CZ3
TRP
A
201
−69.450
31.616
7.739
1.00
24.96
C


ATOM
2814
CH2
TRP
A
201
−69.720
31.918
9.078
1.00
25.08
C


ATOM
2816
CZ2
TRP
A
201
−69.648
30.968
10.056
1.00
24.68
C


ATOM
2818
C
TRP
A
201
−70.351
27.662
5.758
1.00
22.71
C


ATOM
2819
O
TRP
A
201
−71.482
27.921
6.140
1.00
22.76
O


ATOM
2821
N
SER
A
202
−69.776
28.272
4.727
1.00
23.04
N


ATOM
2822
CA
SER
A
202
−70.335
29.500
4.165
1.00
23.29
C


ATOM
2824
CB
SER
A
202
−69.304
30.205
3.290
1.00
23.20
C


ATOM
2827
OG
SER
A
202
−68.306
30.807
4.111
1.00
23.07
O


ATOM
2829
C
SER
A
202
−71.666
29.341
3.432
1.00
23.66
C


ATOM
2830
O
SER
A
202
−72.392
30.310
3.265
1.00
23.38
O


ATOM
2832
N
ILE
A
203
−71.996
28.124
3.016
1.00
24.49
N


ATOM
2833
CA
ILE
A
203
−73.321
27.859
2.460
1.00
25.07
C


ATOM
2835
CB
ILE
A
203
−73.391
26.530
1.653
1.00
24.74
C


ATOM
2837
CG1
ILE
A
203
−72.494
26.587
.423
1.00
24.36
C


ATOM
2840
CD1
ILE
A
203
−72.344
25.255
−.281
1.00
23.81
C


ATOM
2844
CG2
ILE
A
203
−74.795
26.292
1.156
1.00
24.45
C


ATOM
2848
C
ILE
A
203
−74.338
27.858
3.607
1.00
25.91
C


ATOM
2849
O
ILE
A
203
−75.350
28.554
3.546
1.00
26.26
O


ATOM
2851
N
GLU
A
204
−74.051
27.104
4.662
1.00
26.69
N


ATOM
2852
CA
GLU
A
204
−74.929
27.053
5.824
1.00
27.40
C


ATOM
2854
CB
GLU
A
204
−74.286
26.217
6.931
1.00
27.65
C


ATOM
2857
CG
GLU
A
204
−75.132
26.032
8.183
1.00
29.02
C


ATOM
2860
CD
GLU
A
204
−76.530
25.491
7.903
1.00
30.44
C


ATOM
2861
OE1
GLU
A
204
−76.746
24.858
6.844
1.00
31.22
O


ATOM
2862
OE2
GLU
A
204
−77.417
25.703
8.753
1.00
31.96
O


ATOM
2863
C
GLU
A
204
−75.258
28.451
6.342
1.00
27.61
C


ATOM
2864
O
GLU
A
204
−76.409
28.778
6.526
1.00
27.78
O


ATOM
2866
N
ALA
A
205
−74.240
29.274
6.547
1.00
28.15
N


ATOM
2867
CA
ALA
A
205
−74.416
30.637
7.050
1.00
28.41
C


ATOM
2869
CB
ALA
A
205
−73.062
31.285
7.274
1.00
28.41
C


ATOM
2873
C
ALA
A
205
−75.234
31.520
6.136
1.00
28.84
C


ATOM
2874
O
ALA
A
205
−76.050
32.302
6.610
1.00
28.54
O


ATOM
2876
N
TYR
A
206
−74.978
31.408
4.832
1.00
29.84
N


ATOM
2877
CA
TYR
A
206
−75.581
32.281
3.805
1.00
30.41
C


ATOM
2879
CB
TYR
A
206
−74.801
32.170
2.493
1.00
30.20
C


ATOM
2882
CG
TYR
A
206
−75.180
33.173
1.425
1.00
29.62
C


ATOM
2883
CD1
TYR
A
206
−74.721
34.482
1.484
1.00
30.32
C


ATOM
2885
CE1
TYR
A
206
−75.047
35.412
.489
1.00
29.70
C


ATOM
2887
CZ
TYR
A
206
−75.830
35.028
−.578
1.00
28.41
C


ATOM
2888
OH
TYR
A
206
−76.155
35.956
−1.548
1.00
26.74
O


ATOM
2890
CE2
TYR
A
206
−76.291
33.724
−.659
1.00
28.16
C


ATOM
2892
CD2
TYR
A
206
−75.958
32.806
.335
1.00
28.39
C


ATOM
2894
C
TYR
A
206
−77.038
31.918
3.561
1.00
31.15
C


ATOM
2895
O
TYR
A
206
−77.858
32.781
3.268
1.00
31.30
O


ATOM
2897
N
ARG
A
207
−77.341
30.631
3.676
1.00
32.05
N


ATOM
2898
CA
ARG
A
207
−78.691
30.128
3.555
1.00
32.81
C


ATOM
2900
CB
ARG
A
207
−78.684
28.623
3.813
1.00
32.86
C


ATOM
2903
CG
ARG
A
207
−80.028
27.941
3.673
1.00
34.01
C


ATOM
2906
CD
ARG
A
207
−80.066
26.632
4.450
1.00
35.11
C


ATOM
2909
NE
ARG
A
207
−79.096
25.669
3.939
1.00
35.35
N


ATOM
2911
CZ
ARG
A
207
−79.353
24.737
3.022
1.00
36.00
C


ATOM
2912
NH1
ARG
A
207
−80.562
24.611
2.478
1.00
35.55
N


ATOM
2915
NH2
ARG
A
207
−78.381
23.918
2.640
1.00
37.05
N


ATOM
2918
C
ARG
A
207
−79.609
30.826
4.550
1.00
33.57
C


ATOM
2919
O
ARG
A
207
−80.783
31.003
4.263
1.00
33.82
O


ATOM
2921
N
LYS
A
208
−79.064
31.223
5.707
1.00
34.58
N


ATOM
2922
CA
LYS
A
208
−79.835
31.830
6.812
1.00
35.21
C


ATOM
2924
CB
LYS
A
208
−79.137
31.599
8.159
1.00
35.05
C


ATOM
2927
CG
LYS
A
208
−78.847
30.147
8.496
1.00
34.78
C


ATOM
2930
CD
LYS
A
208
−78.583
29.974
9.980
1.00
34.44
C


ATOM
2933
CE
LYS
A
208
−77.992
28.619
10.309
1.00
34.16
C


ATOM
2936
NZ
LYS
A
208
−76.540
28.693
10.572
1.00
33.81
N


ATOM
2940
C
LYS
A
208
−80.075
33.333
6.663
1.00
36.06
C


ATOM
2941
O
LYS
A
208
−81.032
33.857
7.226
1.00
36.19
O


ATOM
2943
N
LYS
A
209
−79.197
34.032
5.946
1.00
36.93
N


ATOM
2944
CA
LYS
A
209
−79.412
35.445
5.652
1.00
37.77
C


ATOM
2946
CB
LYS
A
209
−78.284
35.998
4.779
1.00
38.18
C


ATOM
2949
CG
LYS
A
209
−76.928
36.134
5.458
1.00
39.90
C


ATOM
2952
CD
LYS
A
209
−75.982
37.023
4.621
1.00
42.39
C


ATOM
2955
CE
LYS
A
209
−74.531
37.016
5.169
1.00
44.21
C


ATOM
2958
NZ
LYS
A
209
−74.350
37.688
6.509
1.00
44.75
N


ATOM
2962
C
LYS
A
209
−80.738
35.600
4.911
1.00
37.89
C


ATOM
2963
O
LYS
A
209
−81.049
34.785
4.036
1.00
38.20
O


ATOM
2965
N
GLU
A
210
−81.518
36.632
5.243
1.00
37.87
N


ATOM
2966
CA
GLU
A
210
−82.847
36.797
4.630
1.00
37.72
C


ATOM
2968
CB
GLU
A
210
−83.821
37.578
5.549
1.00
38.19
C


ATOM
2971
CG
GLU
A
210
−83.850
39.130
5.404
1.00
39.68
C


ATOM
2974
CD
GLU
A
210
−85.270
39.736
5.534
1.00
41.27
C


ATOM
2975
OE1
GLU
A
210
−86.172
39.100
6.136
1.00
41.67
O


ATOM
2976
OE2
GLU
A
210
−85.482
40.859
5.019
1.00
42.17
O


ATOM
2977
C
GLU
A
210
−82.760
37.394
3.219
1.00
36.68
C


ATOM
2978
O
GLU
A
210
−83.605
37.103
2.371
1.00
36.39
O


ATOM
2980
N
ASP
A
211
−81.725
38.198
2.969
1.00
35.65
N


ATOM
2981
CA
ASP
A
211
−81.481
38.777
1.632
1.00
34.94
C


ATOM
2983
CB
ASP
A
211
−81.064
40.257
1.740
1.00
35.22
C


ATOM
2986
CG
ASP
A
211
−79.811
40.477
2.599
1.00
35.84
C


ATOM
2987
OD1
ASP
A
211
−79.379
39.557
3.341
1.00
35.60
O


ATOM
2988
OD2
ASP
A
211
−79.276
41.606
2.536
1.00
36.73
O


ATOM
2989
C
ASP
A
211
−80.451
37.989
.811
1.00
33.73
C


ATOM
2990
O
ASP
A
211
−79.753
38.556
−.021
1.00
33.40
O


ATOM
2992
N
ALA
A
212
−80.366
36.682
1.057
1.00
32.53
N


ATOM
2993
CA
ALA
A
212
−79.506
35.783
.293
1.00
31.40
C


ATOM
2995
CB
ALA
A
212
−79.569
34.382
.889
1.00
30.79
C


ATOM
2999
C
ALA
A
212
−79.940
35.762
−1.176
1.00
30.60
C


ATOM
3000
O
ALA
A
212
−81.124
35.594
−1.467
1.00
30.37
O


ATOM
3002
N
ASN
A
213
−79.000
35.967
−2.097
1.00
29.71
N


ATOM
3003
CA
ASN
A
213
−79.304
35.809
−3.520
1.00
29.27
C


ATOM
3005
CB
ASN
A
213
−78.144
36.315
−4.402
1.00
29.30
C


ATOM
3008
CG
ASN
A
213
−78.442
36.217
−5.911
1.00
29.07
C


ATOM
3009
OD1
ASN
A
213
−78.437
37.215
−6.624
1.00
29.38
O


ATOM
3010
ND2
ASN
A
213
−78.691
35.015
−6.389
1.00
28.37
N


ATOM
3013
C
ASN
A
213
−79.634
34.328
−3.785
1.00
28.81
C


ATOM
3014
O
ASN
A
213
−78.784
33.455
−3.658
1.00
29.04
O


ATOM
3016
N
GLN
A
214
−80.880
34.053
−4.145
1.00
28.04
N


ATOM
3017
CA
GLN
A
214
−81.376
32.692
−4.191
1.00
27.32
C


ATOM
3019
CB
GLN
A
214
−82.906
32.700
−4.178
1.00
27.47
C


ATOM
3022
CG
GLN
A
214
−83.505
33.269
−2.889
1.00
27.68
C


ATOM
3025
CD
GLN
A
214
−83.294
32.359
−1.688
1.00
27.54
C


ATOM
3026
OE1
GLN
A
214
−83.940
31.320
−1.571
1.00
28.19
O


ATOM
3027
NE2
GLN
A
214
−82.392
32.748
−.790
1.00
26.90
N


ATOM
3030
C
GLN
A
214
−80.858
31.902
−5.385
1.00
26.71
C


ATOM
3031
O
GLN
A
214
−80.863
30.668
−5.355
1.00
26.91
O


ATOM
3033
N
VAL
A
215
−80.439
32.600
−6.442
1.00
25.81
N


ATOM
3034
CA
VAL
A
215
−79.789
31.947
−7.588
1.00
24.88
C


ATOM
3036
CB
VAL
A
215
−79.651
32.894
−8.808
1.00
24.81
C


ATOM
3038
CG1
VAL
A
215
−78.459
32.483
−9.680
1.00
24.94
C


ATOM
3042
CG2
VAL
A
215
−80.935
32.907
−9.620
1.00
23.74
C


ATOM
3046
C
VAL
A
215
−78.415
31.427
−7.176
1.00
24.18
C


ATOM
3047
O
VAL
A
215
−78.073
30.282
−7.430
1.00
23.74
O


ATOM
3049
N
LEU
A
216
−77.650
32.283
−6.510
1.00
23.78
N


ATOM
3050
CA
LEU
A
216
−76.299
31.961
−6.036
1.00
23.33
C


ATOM
3052
CB
LEU
A
216
−75.680
33.195
−5.373
1.00
23.10
C


ATOM
3055
CG
LEU
A
216
−74.194
33.192
−5.059
1.00
22.91
C


ATOM
3057
CD1
LEU
A
216
−73.383
32.962
−6.312
1.00
22.88
C


ATOM
3061
CD2
LEU
A
216
−73.826
34.518
−4.424
1.00
22.03
C


ATOM
3065
C
LEU
A
216
−76.333
30.797
−5.050
1.00
22.92
C


ATOM
3066
O
LEU
A
216
−75.598
29.826
−5.201
1.00
23.38
O


ATOM
3068
N
LEU
A
217
−77.214
30.890
−4.060
1.00
22.09
N


ATOM
3069
CA
LEU
A
217
−77.367
29.851
−3.054
1.00
21.14
C


ATOM
3071
CB
LEU
A
217
−78.488
30.225
−2.090
1.00
21.11
C


ATOM
3074
CG
LEU
A
217
−78.782
29.236
−.961
1.00
21.08
C


ATOM
3076
CD1
LEU
A
217
−77.703
29.267
.101
1.00
19.87
C


ATOM
3080
CD2
LEU
A
217
−80.146
29.535
−.360
1.00
21.46
C


ATOM
3084
C
LEU
A
217
−77.682
28.517
−3.685
1.00
20.38
C


ATOM
3085
O
LEU
A
217
−77.133
27.508
−3.286
1.00
20.04
O


ATOM
3087
N
GLU
A
218
−78.579
28.512
−4.661
1.00
19.97
N


ATOM
3088
CA
GLU
A
218
−79.027
27.260
−5.273
1.00
19.72
C


ATOM
3090
CB
GLU
A
218
−80.220
27.499
−6.212
1.00
19.87
C


ATOM
3093
CG
GLU
A
218
−81.005
26.228
−6.627
1.00
21.03
C


ATOM
3096
CD
GLU
A
218
−82.303
26.535
−7.424
1.00
22.59
C


ATOM
3097
OE1
GLU
A
218
−82.643
27.730
−7.619
1.00
23.61
O


ATOM
3098
OE2
GLU
A
218
−82.983
25.578
−7.863
1.00
22.31
O


ATOM
3099
C
GLU
A
218
−77.854
26.613
−6.009
1.00
19.03
C


ATOM
3100
O
GLU
A
218
−77.522
25.452
−5.764
1.00
18.97
O


ATOM
3102
N
LEU
A
219
−77.203
27.381
−6.878
1.00
18.06
N


ATOM
3103
CA
LEU
A
219
−76.012
26.907
−7.573
1.00
17.15
C


ATOM
3105
CB
LEU
A
219
−75.439
28.029
−8.418
1.00
16.75
C


ATOM
3108
CG
LEU
A
219
−74.196
27.717
−9.231
1.00
16.01
C


ATOM
3110
CD1
LEU
A
219
−74.511
26.832
−10.404
1.00
12.99
C


ATOM
3114
CD2
LEU
A
219
−73.577
29.028
−9.675
1.00
16.20
C


ATOM
3118
C
LEU
A
219
−74.973
26.409
−6.570
1.00
16.75
C


ATOM
3119
O
LEU
A
219
−74.377
25.355
−6.757
1.00
16.47
O


ATOM
3121
N
ALA
A
220
−74.786
27.169
−5.496
1.00
16.40
N


ATOM
3122
CA
ALA
A
220
−73.858
26.808
−4.422
1.00
16.15
C


ATOM
3124
CB
ALA
A
220
−73.906
27.830
−3.302
1.00
16.13
C


ATOM
3128
C
ALA
A
220
−74.137
25.436
−3.862
1.00
16.03
C


ATOM
3129
O
ALA
A
220
−73.253
24.603
−3.799
1.00
16.30
O


ATOM
3131
N
ILE
A
221
−75.371
25.201
−3.447
1.00
16.24
N


ATOM
3132
CA
ILE
A
221
−75.731
23.916
−2.857
1.00
16.33
C


ATOM
3134
CB
ILE
A
221
−77.203
23.895
−2.352
1.00
15.94
C


ATOM
3136
CG1
ILE
A
221
−77.410
24.879
−1.203
1.00
15.36
C


ATOM
3139
CD1
ILE
A
221
−78.842
25.234
−.962
1.00
14.49
C


ATOM
3143
CG2
ILE
A
221
−77.571
22.537
−1.836
1.00
15.18
C


ATOM
3147
C
ILE
A
221
−75.509
22.841
−3.911
1.00
17.06
C


ATOM
3148
O
ILE
A
221
−74.899
21.819
−3.653
1.00
16.51
O


ATOM
3150
N
LEU
A
222
−75.981
23.138
−5.117
1.00
18.53
N


ATOM
3151
CA
LEU
A
222
−76.006
22.207
−6.243
1.00
19.25
C


ATOM
3153
CB
LEU
A
222
−76.657
22.891
−7.445
1.00
19.18
C


ATOM
3156
CG
LEU
A
222
−77.037
21.972
−8.597
1.00
19.65
C


ATOM
3158
CD1
LEU
A
222
−78.318
22.489
−9.268
1.00
19.24
C


ATOM
3162
CD2
LEU
A
222
−75.869
21.788
−9.597
1.00
18.75
C


ATOM
3166
C
LEU
A
222
−74.618
21.751
−6.630
1.00
20.07
C


ATOM
3167
O
LEU
A
222
−74.381
20.558
−6.778
1.00
20.55
O


ATOM
3169
N
ASP
A
223
−73.710
22.711
−6.797
1.00
20.92
N


ATOM
3170
CA
ASP
A
223
−72.330
22.427
−7.189
1.00
21.43
C


ATOM
3172
CB
ASP
A
223
−71.621
23.723
−7.585
1.00
21.63
C


ATOM
3175
CG
ASP
A
223
−70.202
23.495
−8.070
1.00
22.51
C


ATOM
3176
OD1
ASP
A
223
−69.296
23.282
−7.225
1.00
24.67
O


ATOM
3177
OD2
ASP
A
223
−69.990
23.544
−9.296
1.00
22.73
O


ATOM
3178
C
ASP
A
223
−71.573
21.722
−6.060
1.00
21.79
C


ATOM
3179
O
ASP
A
223
−70.843
20.764
−6.313
1.00
21.73
O


ATOM
3181
N
TYR
A
224
−71.755
22.182
−4.820
1.00
22.14
N


ATOM
3182
CA
TYR
A
224
−71.120
21.529
−3.686
1.00
22.22
C


ATOM
3184
CB
TYR
A
224
−71.462
22.190
−2.355
1.00
22.38
C


ATOM
3187
CG
TYR
A
224
−70.673
21.542
−1.249
1.00
22.65
C


ATOM
3188
CD1
TYR
A
224
−69.356
21.864
−1.053
1.00
22.59
C


ATOM
3190
CE1
TYR
A
224
−68.622
21.258
−.098
1.00
23.38
C


ATOM
3192
CZ
TYR
A
224
−69.177
20.288
.670
1.00
23.22
C


ATOM
3193
OH
TYR
A
224
−68.402
19.684
1.620
1.00
23.93
O


ATOM
3195
CE2
TYR
A
224
−70.483
19.931
.500
1.00
23.36
C


ATOM
3197
CD2
TYR
A
224
−71.221
20.547
−.464
1.00
23.41
C


ATOM
3199
C
TYR
A
224
−71.485
20.065
−3.605
1.00
22.52
C


ATOM
3200
O
TYR
A
224
−70.641
19.233
−3.311
1.00
22.93
O


ATOM
3202
N
ASN
A
225
−72.742
19.749
−3.856
1.00
22.94
N


ATOM
3203
CA
ASN
A
225
−73.187
18.374
−3.801
1.00
23.44
C


ATOM
3205
CB
ASN
A
225
−74.706
18.310
−3.729
1.00
23.34
C


ATOM
3208
CG
ASN
A
225
−75.210
18.579
−2.352
1.00
22.62
C


ATOM
3209
OD1
ASN
A
225
−74.749
17.977
−1.407
1.00
23.33
O


ATOM
3210
ND2
ASN
A
225
−76.146
19.494
−2.223
1.00
22.52
N


ATOM
3213
C
ASN
A
225
−72.694
17.523
−4.959
1.00
24.26
C


ATOM
3214
O
ASN
A
225
−72.408
16.328
−4.767
1.00
24.88
O


ATOM
3216
N
MET
A
226
−72.607
18.119
−6.150
1.00
24.67
N


ATOM
3217
CA
MET
A
226
−72.167
17.395
−7.349
1.00
24.95
C


ATOM
3219
CB
MET
A
226
−72.421
18.237
−8.594
1.00
25.37
C


ATOM
3222
CG
MET
A
226
−71.785
17.713
−9.873
1.00
27.23
C


ATOM
3225
SD
MET
A
226
−70.837
19.010
−10.708
1.00
31.73
S


ATOM
3226
CE
MET
A
226
−72.185
20.000
−11.367
1.00
31.30
C


ATOM
3230
C
MET
A
226
−70.688
17.045
−7.247
1.00
24.70
C


ATOM
3231
O
MET
A
226
−70.291
15.929
−7.568
1.00
24.91
O


ATOM
3233
N
ILE
A
227
−69.873
17.995
−6.799
1.00
24.43
N


ATOM
3234
CA
ILE
A
227
−68.456
17.726
−6.598
1.00
24.18
C


ATOM
3236
CB
ILE
A
227
−67.656
18.971
−6.154
1.00
24.15
C


ATOM
3238
CG1
ILE
A
227
−67.628
20.021
−7.253
1.00
23.64
C


ATOM
3241
CD1
ILE
A
227
−66.853
21.246
−6.880
1.00
23.11
C


ATOM
3245
CG2
ILE
A
227
−66.229
18.603
−5.827
1.00
24.36
C


ATOM
3249
C
ILE
A
227
−68.329
16.645
−5.546
1.00
23.98
C


ATOM
3250
O
ILE
A
227
−67.609
15.689
−5.747
1.00
24.35
O


ATOM
3252
N
GLN
A
228
−69.048
16.779
−4.439
1.00
23.79
N


ATOM
3253
CA
GLN
A
228
−69.020
15.754
−3.382
1.00
23.66
C


ATOM
3255
CB
GLN
A
228
−70.077
16.010
−2.305
1.00
23.64
C


ATOM
3258
CG
GLN
A
228
−69.972
15.049
−1.145
1.00
22.91
C


ATOM
3261
CD
GLN
A
228
−70.891
15.417
−.033
1.00
23.26
C


ATOM
3262
OE1
GLN
A
228
−72.082
15.098
−.069
1.00
25.64
O


ATOM
3263
NE2
GLN
A
228
−70.357
16.083
.978
1.00
21.77
N


ATOM
3266
C
GLN
A
228
−69.243
14.349
−3.893
1.00
23.54
C


ATOM
3267
O
GLN
A
228
−68.664
13.412
−3.357
1.00
23.59
O


ATOM
3269
N
SER
A
229
−70.105
14.194
−4.893
1.00
23.27
N


ATOM
3270
CA
SER
A
229
−70.394
12.868
−5.406
1.00
23.35
C


ATOM
3272
CB
SER
A
229
−71.753
12.812
−6.095
1.00
23.31
C


ATOM
3275
OG
SER
A
229
−71.836
13.823
−7.060
1.00
24.31
O


ATOM
3277
C
SER
A
229
−69.287
12.394
−6.331
1.00
23.19
C


ATOM
3278
O
SER
A
229
−69.130
11.194
−6.512
1.00
23.44
O


ATOM
3280
N
VAL
A
230
−68.512
13.306
−6.914
1.00
23.14
N


ATOM
3281
CA
VAL
A
230
−67.269
12.874
−7.552
1.00
23.00
C


ATOM
3283
CB
VAL
A
230
−66.469
13.998
−8.253
1.00
22.75
C


ATOM
3285
CG1
VAL
A
230
−65.091
13.470
−8.667
1.00
21.87
C


ATOM
3289
CG2
VAL
A
230
−67.222
14.539
−9.459
1.00
21.74
C


ATOM
3293
C
VAL
A
230
−66.417
12.268
−6.452
1.00
23.35
C


ATOM
3294
O
VAL
A
230
−65.917
11.173
−6.589
1.00
23.68
O


ATOM
3296
N
TYR
A
231
−66.284
12.968
−5.340
1.00
23.96
N


ATOM
3297
CA
TYR
A
231
−65.414
12.509
−4.274
1.00
24.60
C


ATOM
3299
CB
TYR
A
231
−65.486
13.426
−3.051
1.00
24.69
C


ATOM
3302
CG
TYR
A
231
−64.963
14.837
−3.211
1.00
24.11
C


ATOM
3303
CD1
TYR
A
231
−64.071
15.190
−4.214
1.00
24.31
C


ATOM
3305
CE1
TYR
A
231
−63.592
16.491
−4.322
1.00
24.63
C


ATOM
3307
CZ
TYR
A
231
−63.994
17.441
−3.406
1.00
25.13
C


ATOM
3308
OH
TYR
A
231
−63.554
18.754
−3.456
1.00
24.64
O


ATOM
3310
CE2
TYR
A
231
−64.863
17.086
−2.402
1.00
25.76
C


ATOM
3312
CD2
TYR
A
231
−65.329
15.800
−2.308
1.00
24.28
C


ATOM
3314
C
TYR
A
231
−65.785
11.111
−3.833
1.00
25.26
C


ATOM
3315
O
TYR
A
231
−64.917
10.315
−3.488
1.00
25.44
O


ATOM
3317
N
GLN
A
232
−67.079
10.819
−3.833
1.00
26.04
N


ATOM
3318
CA
GLN
A
232
−67.566
9.532
−3.362
1.00
26.57
C


ATOM
3320
CB
GLN
A
232
−69.060
9.621
−3.057
1.00
26.44
C


ATOM
3323
CG
GLN
A
232
−69.339
10.397
−1.778
1.00
26.25
C


ATOM
3326
CD
GLN
A
232
−70.786
10.819
−1.630
1.00
26.53
C


ATOM
3327
OE1
GLN
A
232
−71.667
10.305
−2.318
1.00
27.77
O


ATOM
3328
NE2
GLN
A
232
−71.040
11.759
−.723
1.00
25.51
N


ATOM
3331
C
GLN
A
232
−67.238
8.414
−4.351
1.00
27.44
C


ATOM
3332
O
GLN
A
232
−66.852
7.319
−3.935
1.00
27.33
O


ATOM
3334
N
ARG
A
233
−67.373
8.691
−5.649
1.00
28.66
N


ATOM
3335
CA
ARG
A
233
−66.905
7.768
−6.685
1.00
29.86
C


ATOM
3337
CB
ARG
A
233
−67.212
8.292
−8.090
1.00
30.08
C


ATOM
3340
CG
ARG
A
233
−66.378
7.634
−9.179
1.00
32.80
C


ATOM
3343
CD
ARG
A
233
−66.913
7.923
−10.572
1.00
36.74
C


ATOM
3346
NE
ARG
A
233
−66.962
9.363
−10.860
1.00
40.33
N


ATOM
3348
CZ
ARG
A
233
−68.069
10.119
−10.891
1.00
43.12
C


ATOM
3349
NH1
ARG
A
233
−69.276
9.600
−10.655
1.00
44.55
N


ATOM
3352
NH2
ARG
A
233
−67.971
11.418
−11.169
1.00
43.38
N


ATOM
3355
C
ARG
A
233
−65.401
7.518
−6.514
1.00
30.34
C


ATOM
3356
O
ARG
A
233
−64.962
6.374
−6.412
1.00
30.55
O


ATOM
3358
N
ASP
A
234
−64.621
8.591
−6.461
1.00
31.00
N


ATOM
3359
CA
ASP
A
234
−63.187
8.487
−6.205
1.00
31.48
C


ATOM
3361
CB
ASP
A
234
−62.594
9.870
−5.942
1.00
31.56
C


ATOM
3364
CG
ASP
A
234
−62.573
10.741
−7.167
1.00
32.78
C


ATOM
3365
OD1
ASP
A
234
−62.911
10.249
−8.276
1.00
34.25
O


ATOM
3366
OD2
ASP
A
234
−62.215
11.930
−7.011
1.00
34.81
O


ATOM
3367
C
ASP
A
234
−62.885
7.596
−5.010
1.00
31.70
C


ATOM
3368
O
ASP
A
234
−61.985
6.780
−5.053
1.00
31.56
O


ATOM
3370
N
LEU
A
235
−63.647
7.766
−3.943
1.00
32.43
N


ATOM
3371
CA
LEU
A
235
−63.366
7.102
−2.685
1.00
33.04
C


ATOM
3373
CB
LEU
A
235
−64.072
7.833
−1.553
1.00
32.57
C


ATOM
3376
CG
LEU
A
235
−63.884
7.252
−.167
1.00
30.85
C


ATOM
3378
CD1
LEU
A
235
−62.428
7.261
.174
1.00
28.78
C


ATOM
3382
CD2
LEU
A
235
−64.703
8.050
.823
1.00
29.93
C


ATOM
3386
C
LEU
A
235
−63.789
5.637
−2.686
1.00
34.69
C


ATOM
3387
O
LEU
A
235
−63.123
4.812
−2.065
1.00
35.29
O


ATOM
3389
N
ARG
A
236
−64.893
5.299
−3.354
1.00
36.09
N


ATOM
3390
CA
ARG
A
236
−65.290
3.893
−3.458
1.00
37.26
C


ATOM
3392
CB
ARG
A
236
−66.672
3.736
−4.103
1.00
37.64
C


ATOM
3395
CG
ARG
A
236
−67.839
4.000
−3.157
1.00
39.15
C


ATOM
3398
CD
ARG
A
236
−69.162
3.528
−3.741
1.00
40.25
C


ATOM
3401
NE
ARG
A
236
−69.385
4.046
−5.095
1.00
41.64
N


ATOM
3403
CZ
ARG
A
236
−69.837
5.269
−5.392
1.00
42.54
C


ATOM
3404
NH1
ARG
A
236
−70.115
6.147
−4.430
1.00
42.18
N


ATOM
3407
NH2
ARG
A
236
−70.012
5.621
−6.668
1.00
43.04
N


ATOM
3410
C
ARG
A
236
−64.266
3.108
−4.262
1.00
37.81
C


ATOM
3411
O
ARG
A
236
−64.104
1.912
−4.060
1.00
38.07
O


ATOM
3413
N
GLU
A
237
−63.584
3.801
−5.168
1.00
38.69
N


ATOM
3414
CA
GLU
A
237
−62.639
3.189
−6.102
1.00
39.45
C


ATOM
3416
CB
GLU
A
237
−62.452
4.108
−7.338
1.00
40.25
C


ATOM
3419
CG
GLU
A
237
−62.268
3.387
−8.710
1.00
43.02
C


ATOM
3422
CD
GLU
A
237
−60.835
3.458
−9.287
1.00
46.64
C


ATOM
3423
OE1
GLU
A
237
−60.093
4.440
−8.997
1.00
48.03
O


ATOM
3424
OE2
GLU
A
237
−60.466
2.519
−10.047
1.00
48.35
O


ATOM
3425
C
GLU
A
237
−61.310
2.905
−5.408
1.00
38.70
C


ATOM
3426
O
GLU
A
237
−60.832
1.782
−5.440
1.00
38.33
O


ATOM
3428
N
THR
A
238
−60.726
3.908
−4.764
1.00
38.40
N


ATOM
3429
CA
THR
A
238
−59.504
3.669
−4.009
1.00
38.74
C


ATOM
3431
CB
THR
A
238
−58.710
4.965
−3.593
1.00
38.78
C


ATOM
3433
OG1
THR
A
238
−59.294
5.583
−2.444
1.00
38.38
O


ATOM
3435
CG2
THR
A
238
−58.612
5.963
−4.743
1.00
38.94
C


ATOM
3439
C
THR
A
238
−59.802
2.834
−2.773
1.00
39.05
C


ATOM
3440
O
THR
A
238
−58.886
2.294
−2.153
1.00
39.17
O


ATOM
3442
N
SER
A
239
−61.076
2.717
−2.408
1.00
39.34
N


ATOM
3443
CA
SER
A
239
−61.443
1.841
−1.304
1.00
39.47
C


ATOM
3445
CB
SER
A
239
−62.844
2.149
−.792
1.00
39.34
C


ATOM
3448
OG
SER
A
239
−63.087
1.428
.396
1.00
39.94
O


ATOM
3450
C
SER
A
239
−61.313
.367
−1.699
1.00
39.53
C


ATOM
3451
O
SER
A
239
−60.834
−.439
−.900
1.00
39.53
O


ATOM
3453
N
ARG
A
240
−61.728
.021
−2.921
1.00
39.69
N


ATOM
3454
CA
ARG
A
240
−61.559
−1.341
−3.439
1.00
39.79
C


ATOM
3456
CB
ARG
A
240
−62.105
−1.492
−4.867
1.00
40.34
C


ATOM
3459
CG
ARG
A
240
−63.624
−1.715
−4.947
1.00
43.03
C


ATOM
3462
CD
ARG
A
240
−64.104
−2.125
−6.364
1.00
46.66
C


ATOM
3465
NE
ARG
A
240
−63.780
−1.136
−7.416
1.00
50.46
N


ATOM
3467
CZ
ARG
A
240
−64.535
−.082
−7.775
1.00
53.13
C


ATOM
3468
NH1
ARG
A
240
−64.112
.732
−8.749
1.00
53.13
N


ATOM
3471
NH2
ARG
A
240
−65.707
.178
−7.178
1.00
54.02
N


ATOM
3474
C
ARG
A
240
−60.089
−1.704
−3.414
1.00
38.94
C


ATOM
3475
O
ARG
A
240
−59.732
−2.795
−2.978
1.00
39.09
O


ATOM
3477
N
TRP
A
241
−59.246
−.775
−3.862
1.00
37.92
N


ATOM
3478
CA
TRP
A
241
−57.787
−.947
−3.842
1.00
36.93
C


ATOM
3480
CB
TRP
A
241
−57.099
.318
−4.388
1.00
36.57
C


ATOM
3483
CG
TRP
A
241
−55.624
.333
−4.209
1.00
34.71
C


ATOM
3484
CD1
TRP
A
241
−54.702
−.312
−4.969
1.00
33.50
C


ATOM
3486
NE1
TRP
A
241
−53.441
−.068
−4.482
1.00
32.62
N


ATOM
3488
CE2
TRP
A
241
−53.538
.747
−3.392
1.00
31.16
C


ATOM
3489
CD2
TRP
A
241
−54.896
1.022
−3.191
1.00
32.61
C


ATOM
3490
CE3
TRP
A
241
−55.268
1.837
−2.117
1.00
32.63
C


ATOM
3492
CZ3
TRP
A
241
−54.293
2.345
−1.307
1.00
31.31
C


ATOM
3494
CH2
TRP
A
241
−52.956
2.053
−1.537
1.00
31.81
C


ATOM
3496
CZ2
TRP
A
241
−52.560
1.252
−2.577
1.00
31.18
C


ATOM
3498
C
TRP
A
241
−57.263
−1.274
−2.444
1.00
36.67
C


ATOM
3499
O
TRP
A
241
−56.540
−2.247
−2.252
1.00
36.32
O


ATOM
3501
N
TRP
A
242
−57.647
−.460
−1.471
1.00
36.59
N


ATOM
3502
CA
TRP
A
242
−57.150
−.593
−.100
1.00
36.80
C


ATOM
3504
CB
TRP
A
242
−57.694
.582
.734
1.00
36.47
C


ATOM
3507
CG
TRP
A
242
−57.113
.754
2.107
1.00
35.59
C


ATOM
3508
CD1
TRP
A
242
−57.806
.831
3.270
1.00
35.14
C


ATOM
3510
NE1
TRP
A
242
−56.950
.999
4.328
1.00
34.47
N


ATOM
3512
CE2
TRP
A
242
−55.667
1.032
3.859
1.00
34.64
C


ATOM
3513
CD2
TRP
A
242
−55.728
.884
2.461
1.00
35.26
C


ATOM
3514
CE3
TRP
A
242
−54.531
.882
1.732
1.00
35.22
C


ATOM
3516
CZ3
TRP
A
242
−53.342
1.024
2.409
1.00
34.30
C


ATOM
3518
CH2
TRP
A
242
−53.318
1.169
3.799
1.00
34.70
C


ATOM
3520
CZ2
TRP
A
242
−54.467
1.173
4.542
1.00
34.63
C


ATOM
3522
C
TRP
A
242
−57.482
−1.975
.524
1.00
37.34
C


ATOM
3523
O
TRP
A
242
−56.628
−2.623
1.126
1.00
36.53
O


ATOM
3525
N
ARG
A
243
−58.720
−2.421
.348
1.00
38.54
N


ATOM
3526
CA
ARG
A
243
−59.149
−3.734
.822
1.00
39.71
C


ATOM
3528
CB
ARG
A
243
−60.669
−3.896
.687
1.00
40.10
C


ATOM
3531
CG
ARG
A
243
−61.495
−3.134
1.747
1.00
42.18
C


ATOM
3534
CD
ARG
A
243
−62.826
−2.623
1.169
1.00
45.18
C


ATOM
3537
NE
ARG
A
243
−63.506
−3.656
.369
1.00
48.22
N


ATOM
3539
CZ
ARG
A
243
−64.374
−3.431
−.629
1.00
49.95
C


ATOM
3540
NH1
ARG
A
243
−64.717
−2.182
−.991
1.00
50.13
N


ATOM
3543
NH2
ARG
A
243
−64.911
−4.477
−1.273
1.00
49.77
N


ATOM
3546
C
ARG
A
243
−58.438
−4.852
.068
1.00
40.08
C


ATOM
3547
O
ARG
A
243
−58.084
−5.870
.665
1.00
40.45
O


ATOM
3549
N
ARG
A
244
−58.236
−4.663
−1.236
1.00
40.42
N


ATOM
3550
CA
ARG
A
244
−57.499
−5.621
−2.063
1.00
40.65
C


ATOM
3552
CB
ARG
A
244
−57.370
−5.100
−3.503
1.00
41.29
C


ATOM
3555
CG
ARG
A
244
−56.939
−6.126
−4.560
1.00
43.27
C


ATOM
3558
CD
ARG
A
244
−58.090
−7.062
−4.952
1.00
46.01
C


ATOM
3561
NE
ARG
A
244
−57.595
−8.337
−5.485
1.00
48.77
N


ATOM
3563
CZ
ARG
A
244
−57.075
−9.332
−4.752
1.00
51.17
C


ATOM
3564
NH1
ARG
A
244
−56.968
−9.234
−3.422
1.00
51.63
N


ATOM
3567
NH2
ARG
A
244
−56.656
−10.448
−5.353
1.00
52.11
N


ATOM
3570
C
ARG
A
244
−56.120
−5.861
−1.465
1.00
40.12
C


ATOM
3571
O
ARG
A
244
−55.728
−7.000
−1.235
1.00
39.96
O


ATOM
3573
N
VAL
A
245
−55.399
−4.778
−1.201
1.00
39.78
N


ATOM
3574
CA
VAL
A
245
−54.099
−4.858
−.543
1.00
39.68
C


ATOM
3576
CB
VAL
A
245
−53.430
−3.458
−.437
1.00
39.70
C


ATOM
3578
CG1
VAL
A
245
−53.133
−2.914
−1.824
1.00
39.54
C


ATOM
3582
CG2
VAL
A
245
−52.145
−3.507
.395
1.00
39.41
C


ATOM
3586
C
VAL
A
245
−54.262
−5.472
.841
1.00
39.73
C


ATOM
3587
O
VAL
A
245
−53.455
−6.291
1.253
1.00
39.53
O


ATOM
3589
N
GLY
A
246
−55.312
−5.051
1.544
1.00
40.11
N


ATOM
3590
CA
GLY
A
246
−55.705
−5.617
2.839
1.00
40.35
C


ATOM
3593
C
GLY
A
246
−54.621
−5.648
3.894
1.00
40.58
C


ATOM
3594
O
GLY
A
246
−54.396
−6.676
4.510
1.00
40.68
O


ATOM
3596
N
LEU
A
247
−53.963
−4.522
4.129
1.00
41.15
N


ATOM
3597
CA
LEU
A
247
−52.778
−4.519
4.982
1.00
41.71
C


ATOM
3599
CB
LEU
A
247
−51.808
−3.422
4.537
1.00
41.60
C


ATOM
3602
CG
LEU
A
247
−50.334
−3.815
4.441
1.00
40.83
C


ATOM
3604
CD1
LEU
A
247
−50.158
−5.014
3.539
1.00
40.54
C


ATOM
3608
CD2
LEU
A
247
−49.534
−2.644
3.918
1.00
39.92
C


ATOM
3612
C
LEU
A
247
−53.136
−4.385
6.471
1.00
42.60
C


ATOM
3613
O
LEU
A
247
−52.588
−5.111
7.313
1.00
42.06
O


ATOM
3615
N
ALA
A
248
−54.064
−3.475
6.788
1.00
43.75
N


ATOM
3616
CA
ALA
A
248
−54.603
−3.352
8.162
1.00
44.52
C


ATOM
3618
CB
ALA
A
248
−55.712
−2.296
8.210
1.00
44.31
C


ATOM
3622
C
ALA
A
248
−55.129
−4.706
8.695
1.00
45.10
C


ATOM
3623
O
ALA
A
248
−54.969
−5.041
9.875
1.00
44.96
O


ATOM
3625
N
THR
A
249
−55.742
−5.477
7.802
1.00
45.91
N


ATOM
3626
CA
THR
A
249
−56.328
−6.768
8.154
1.00
46.50
C


ATOM
3628
CB
THR
A
249
−57.303
−7.277
7.041
1.00
46.48
C


ATOM
3630
OG1
THR
A
249
−56.583
−8.039
6.063
1.00
46.20
O


ATOM
3632
CG2
THR
A
249
−58.033
−6.102
6.350
1.00
46.70
C


ATOM
3636
C
THR
A
249
−55.257
−7.840
8.447
1.00
47.06
C


ATOM
3637
O
THR
A
249
−55.531
−8.813
9.159
1.00
47.22
O


ATOM
3639
N
LYS
A
250
−54.049
−7.661
7.905
1.00
47.52
N


ATOM
3640
CA
LYS
A
250
−52.952
−8.620
8.096
1.00
47.91
C


ATOM
3642
CB
LYS
A
250
−52.319
−8.976
6.744
1.00
48.09
C


ATOM
3645
CG
LYS
A
250
−52.911
−10.229
6.088
1.00
48.91
C


ATOM
3648
CD
LYS
A
250
−52.210
−11.510
6.585
1.00
49.88
C


ATOM
3651
CE
LYS
A
250
−53.066
−12.760
6.349
1.00
50.12
C


ATOM
3654
NZ
LYS
A
250
−52.385
−14.011
6.791
1.00
49.99
N


ATOM
3658
C
LYS
A
250
−51.880
−8.129
9.078
1.00
48.13
C


ATOM
3659
O
LYS
A
250
−51.252
−8.939
9.759
1.00
47.89
O


ATOM
3661
N
LEU
A
251
−51.667
−6.812
9.134
1.00
48.63
N


ATOM
3662
CA
LEU
A
251
−50.758
−6.187
10.114
1.00
48.83
C


ATOM
3664
CB
LEU
A
251
−49.981
−5.020
9.485
1.00
48.74
C


ATOM
3667
CG
LEU
A
251
−48.569
−5.296
8.960
1.00
48.51
C


ATOM
3669
CD1
LEU
A
251
−48.472
−6.594
8.174
1.00
47.96
C


ATOM
3673
CD2
LEU
A
251
−48.102
−4.115
8.116
1.00
48.76
C


ATOM
3677
C
LEU
A
251
−51.559
−5.703
11.324
1.00
49.17
C


ATOM
3678
O
LEU
A
251
−52.176
−4.632
11.304
1.00
49.28
O


ATOM
3680
N
HIS
A
252
−51.521
−6.486
12.393
1.00
49.53
N


ATOM
3681
CA
HIS
A
252
−52.470
−6.322
13.494
1.00
50.02
C


ATOM
3683
CB
HIS
A
252
−52.598
−7.647
14.266
1.00
50.42
C


ATOM
3686
CG
HIS
A
252
−52.860
−8.834
13.380
1.00
52.23
C


ATOM
3687
ND1
HIS
A
252
−54.032
−8.989
12.667
1.00
53.75
N


ATOM
3689
CE1
HIS
A
252
−53.978
−10.113
11.973
1.00
54.43
C


ATOM
3691
NE2
HIS
A
252
−52.810
−10.689
12.201
1.00
54.52
N


ATOM
3693
CD2
HIS
A
252
−52.090
−9.910
13.077
1.00
53.70
C


ATOM
3695
C
HIS
A
252
−52.161
−5.147
14.441
1.00
49.64
C


ATOM
3696
O
HIS
A
252
−52.951
−4.849
15.336
1.00
49.61
O


ATOM
3698
N
PHE
A
253
−51.027
−4.483
14.229
1.00
49.37
N


ATOM
3699
CA
PHE
A
253
−50.652
−3.273
14.973
1.00
49.15
C


ATOM
3701
CB
PHE
A
253
−49.144
−3.273
15.260
1.00
49.07
C


ATOM
3704
CG
PHE
A
253
−48.307
−3.112
14.025
1.00
48.30
C


ATOM
3705
CD1
PHE
A
253
−48.028
−1.851
13.518
1.00
48.10
C


ATOM
3707
CE1
PHE
A
253
−47.290
−1.702
12.349
1.00
48.21
C


ATOM
3709
CZ
PHE
A
253
−46.825
−2.825
11.675
1.00
47.88
C


ATOM
3711
CE2
PHE
A
253
−47.101
−4.090
12.175
1.00
47.66
C


ATOM
3713
CD2
PHE
A
253
−47.842
−4.226
13.338
1.00
47.74
C


ATOM
3715
C
PHE
A
253
−50.974
−2.006
14.176
1.00
49.31
C


ATOM
3716
O
PHE
A
253
−50.846
−.893
14.702
1.00
49.01
O


ATOM
3718
N
ALA
A
254
−51.365
−2.185
12.910
1.00
49.48
N


ATOM
3719
CA
ALA
A
254
−51.412
−1.095
11.931
1.00
49.63
C


ATOM
3721
CB
ALA
A
254
−51.344
−1.663
10.524
1.00
49.64
C


ATOM
3725
C
ALA
A
254
−52.650
−.224
12.061
1.00
49.77
C


ATOM
3726
O
ALA
A
254
−53.761
−.735
12.219
1.00
49.86
O


ATOM
3728
N
ARG
A
255
−52.452
1.090
11.975
1.00
49.93
N


ATOM
3729
CA
ARG
A
255
−53.562
2.042
11.908
1.00
50.27
C


ATOM
3731
CB
ARG
A
255
−53.094
3.468
12.237
1.00
50.43
C


ATOM
3734
CG
ARG
A
255
−52.678
3.736
13.696
1.00
50.82
C


ATOM
3737
CD
ARG
A
255
−52.242
5.211
13.887
1.00
51.32
C


ATOM
3740
NE
ARG
A
255
−51.003
5.522
13.155
1.00
51.81
N


ATOM
3742
CZ
ARG
A
255
−50.571
6.746
12.829
1.00
51.67
C


ATOM
3743
NH1
ARG
A
255
−51.264
7.839
13.146
1.00
51.63
N


ATOM
3746
NH2
ARG
A
255
−49.427
6.877
12.162
1.00
51.52
N


ATOM
3749
C
ARG
A
255
−54.160
2.040
10.497
1.00
50.32
C


ATOM
3750
O
ARG
A
255
−53.416
2.081
9.504
1.00
50.35
O


ATOM
3752
N
ASP
A
256
−55.492
2.005
10.412
1.00
50.17
N


ATOM
3753
CA
ASP
A
256
−56.190
2.090
9.128
1.00
50.18
C


ATOM
3755
CB
ASP
A
256
−57.259
1.009
9.037
1.00
50.37
C


ATOM
3758
CG
ASP
A
256
−58.095
1.130
7.780
1.00
50.96
C


ATOM
3759
OD1
ASP
A
256
−59.252
1.601
7.881
1.00
52.00
O


ATOM
3760
OD2
ASP
A
256
−57.581
.787
6.693
1.00
50.94
O


ATOM
3761
C
ASP
A
256
−56.838
3.470
8.945
1.00
49.85
C


ATOM
3762
O
ASP
A
256
−57.812
3.804
9.624
1.00
50.13
O


ATOM
3764
N
ARG
A
257
−56.315
4.263
8.013
1.00
49.11
N


ATOM
3765
CA
ARG
A
257
−56.712
5.665
7.913
1.00
48.59
C


ATOM
3767
CB
ARG
A
257
−55.622
6.553
8.529
1.00
48.79
C


ATOM
3770
CG
ARG
A
257
−55.318
6.275
10.006
1.00
49.85
C


ATOM
3773
CD
ARG
A
257
−56.538
6.480
10.908
1.00
51.01
C


ATOM
3776
NE
ARG
A
257
−56.198
7.274
12.089
1.00
51.80
N


ATOM
3778
CZ
ARG
A
257
−55.779
6.791
13.260
1.00
52.00
C


ATOM
3779
NH1
ARG
A
257
−55.643
5.486
13.468
1.00
51.64
N


ATOM
3782
NH2
ARG
A
257
−55.501
7.638
14.245
1.00
52.62
N


ATOM
3785
C
ARG
A
257
−56.988
6.112
6.477
1.00
47.58
C


ATOM
3786
O
ARG
A
257
−56.476
7.144
6.031
1.00
47.40
O


ATOM
3788
N
LEU
A
258
−57.814
5.352
5.761
1.00
46.18
N


ATOM
3789
CA
LEU
A
258
−58.094
5.672
4.358
1.00
44.78
C


ATOM
3791
CB
LEU
A
258
−58.777
4.508
3.629
1.00
44.57
C


ATOM
3794
CG
LEU
A
258
−58.917
4.731
2.121
1.00
43.79
C


ATOM
3796
CD1
LEU
A
258
−57.557
4.661
1.478
1.00
43.89
C


ATOM
3800
CD2
LEU
A
258
−59.850
3.733
1.492
1.00
42.88
C


ATOM
3804
C
LEU
A
258
−58.970
6.907
4.259
1.00
43.52
C


ATOM
3805
O
LEU
A
258
−58.643
7.849
3.545
1.00
43.42
O


ATOM
3807
N
ILE
A
259
−60.080
6.895
4.983
1.00
41.98
N


ATOM
3808
CA
ILE
A
259
−61.072
7.948
4.843
1.00
40.89
C


ATOM
3810
CB
ILE
A
259
−62.349
7.703
5.693
1.00
41.02
C


ATOM
3812
CG1
ILE
A
259
−62.846
6.248
5.570
1.00
41.82
C


ATOM
3815
CD1
ILE
A
259
−64.029
5.872
6.508
1.00
42.29
C


ATOM
3819
CG2
ILE
A
259
−63.446
8.662
5.262
1.00
40.47
C


ATOM
3823
C
ILE
A
259
−60.424
9.253
5.273
1.00
39.74
C


ATOM
3824
O
ILE
A
259
−60.607
10.291
4.635
1.00
39.25
O


ATOM
3826
N
GLU
A
260
−59.650
9.191
6.355
1.00
38.46
N


ATOM
3827
CA
GLU
A
260
−58.951
10.366
6.846
1.00
37.44
C


ATOM
3829
CB
GLU
A
260
−58.183
10.072
8.140
1.00
37.74
C


ATOM
3832
CG
GLU
A
260
−59.041
9.934
9.393
1.00
38.71
C


ATOM
3835
CD
GLU
A
260
−59.469
8.501
9.693
1.00
41.00
C


ATOM
3836
OE1
GLU
A
260
−59.273
7.594
8.842
1.00
42.70
O


ATOM
3837
OE2
GLU
A
260
−60.012
8.281
10.800
1.00
42.43
O


ATOM
3838
C
GLU
A
260
−57.995
10.841
5.764
1.00
35.94
C


ATOM
3839
O
GLU
A
260
−57.981
12.020
5.418
1.00
36.10
O


ATOM
3841
N
SER
A
261
−57.222
9.908
5.212
1.00
34.02
N


ATOM
3842
CA
SER
A
261
−56.263
10.229
4.152
1.00
32.47
C


ATOM
3844
CB
SER
A
261
−55.407
9.015
3.774
1.00
32.51
C


ATOM
3847
OG
SER
A
261
−54.253
8.940
4.584
1.00
33.14
O


ATOM
3849
C
SER
A
261
−56.894
10.764
2.889
1.00
30.82
C


ATOM
3850
O
SER
A
261
−56.199
11.306
2.062
1.00
30.79
O


ATOM
3852
N
PHE
A
262
−58.194
10.589
2.713
1.00
29.25
N


ATOM
3853
CA
PHE
A
262
−58.861
11.091
1.514
1.00
27.98
C


ATOM
3855
CB
PHE
A
262
−60.011
10.185
1.119
1.00
27.57
C


ATOM
3858
CG
PHE
A
262
−60.473
10.423
−.251
1.00
26.11
C


ATOM
3859
CD1
PHE
A
262
−59.763
9.914
−1.318
1.00
25.14
C


ATOM
3861
CE1
PHE
A
262
−60.169
10.147
−2.605
1.00
24.32
C


ATOM
3863
CZ
PHE
A
262
−61.284
10.917
−2.840
1.00
24.36
C


ATOM
3865
CE2
PHE
A
262
−61.987
11.445
−1.785
1.00
25.23
C


ATOM
3867
CD2
PHE
A
262
−61.575
11.201
−.492
1.00
25.61
C


ATOM
3869
C
PHE
A
262
−59.394
12.507
1.707
1.00
27.29
C


ATOM
3870
O
PHE
A
262
−59.275
13.359
.821
1.00
27.39
O


ATOM
3872
N
TYR
A
263
−60.025
12.723
2.856
1.00
26.19
N


ATOM
3873
CA
TYR
A
263
−60.415
14.052
3.310
1.00
25.22
C


ATOM
3875
CB
TYR
A
263
−60.975
13.942
4.735
1.00
25.21
C


ATOM
3878
CG
TYR
A
263
−61.037
15.199
5.578
1.00
25.37
C


ATOM
3879
CD1
TYR
A
263
−62.020
16.152
5.385
1.00
24.95
C


ATOM
3881
CE1
TYR
A
263
−62.084
17.282
6.197
1.00
26.54
C


ATOM
3883
CZ
TYR
A
263
−61.158
17.455
7.229
1.00
27.44
C


ATOM
3884
OH
TYR
A
263
−61.186
18.567
8.059
1.00
28.97
O


ATOM
3886
CE2
TYR
A
263
−60.185
16.512
7.438
1.00
27.10
C


ATOM
3888
CD2
TYR
A
263
−60.136
15.390
6.626
1.00
26.91
C


ATOM
3890
C
TYR
A
263
−59.190
14.946
3.238
1.00
24.29
C


ATOM
3891
O
TYR
A
263
−59.267
16.077
2.757
1.00
24.13
O


ATOM
3893
N
TRP
A
264
−58.055
14.415
3.682
1.00
23.01
N


ATOM
3894
CA
TRP
A
264
−56.789
15.121
3.567
1.00
22.32
C


ATOM
3896
CB
TRP
A
264
−55.642
14.261
4.119
1.00
22.26
C


ATOM
3899
CG
TRP
A
264
−54.326
14.874
3.860
1.00
22.16
C


ATOM
3900
CD1
TRP
A
264
−53.614
14.821
2.699
1.00
22.68
C


ATOM
3902
NE1
TRP
A
264
−52.456
15.538
2.818
1.00
23.08
N


ATOM
3904
CE2
TRP
A
264
−52.407
16.083
4.072
1.00
23.07
C


ATOM
3905
CD2
TRP
A
264
−53.579
15.686
4.753
1.00
22.18
C


ATOM
3906
CE3
TRP
A
264
−53.782
16.119
6.066
1.00
22.57
C


ATOM
3908
CZ3
TRP
A
264
−52.824
16.925
6.657
1.00
23.43
C


ATOM
3910
CH2
TRP
A
264
−51.656
17.297
5.955
1.00
24.14
C


ATOM
3912
CZ2
TRP
A
264
−51.433
16.886
4.663
1.00
23.64
C


ATOM
3914
C
TRP
A
264
−56.485
15.523
2.112
1.00
21.50
C


ATOM
3915
O
TRP
A
264
−56.179
16.682
1.820
1.00
21.29
O


ATOM
3917
N
ALA
A
265
−56.561
14.547
1.213
1.00
20.41
N


ATOM
3918
CA
ALA
A
265
−56.242
14.760
−.187
1.00
19.63
C


ATOM
3920
CB
ALA
A
265
−56.298
13.437
−.953
1.00
19.39
C


ATOM
3924
C
ALA
A
265
−57.176
15.792
−.798
1.00
19.07
C


ATOM
3925
O
ALA
A
265
−56.760
16.573
−1.633
1.00
18.99
O


ATOM
3927
N
VAL
A
266
−58.431
15.814
−.359
1.00
18.78
N


ATOM
3928
CA
VAL
A
266
−59.396
16.828
−.818
1.00
18.56
C


ATOM
3930
CB
VAL
A
266
−60.839
16.541
−.278
1.00
18.41
C


ATOM
3932
CG1
VAL
A
266
−61.405
15.298
−.935
1.00
18.88
C


ATOM
3936
CG2
VAL
A
266
−61.780
17.709
−.505
1.00
17.21
C


ATOM
3940
C
VAL
A
266
−58.947
18.257
−.450
1.00
18.43
C


ATOM
3941
O
VAL
A
266
−59.250
19.200
−1.171
1.00
18.83
O


ATOM
3943
N
GLY
A
267
−58.230
18.411
.663
1.00
17.96
N


ATOM
3944
CA
GLY
A
267
−57.714
19.712
1.067
1.00
17.45
C


ATOM
3947
C
GLY
A
267
−56.687
20.180
.070
1.00
17.20
C


ATOM
3948
O
GLY
A
267
−56.574
21.365
−.215
1.00
17.41
O


ATOM
3950
N
VAL
A
268
−55.959
19.219
−.480
1.00
16.88
N


ATOM
3951
CA
VAL
A
268
−54.822
19.487
−1.319
1.00
16.62
C


ATOM
3953
CB
VAL
A
268
−53.833
18.300
−1.290
1.00
16.19
C


ATOM
3955
CG1
VAL
A
268
−52.691
18.536
−2.240
1.00
15.50
C


ATOM
3959
CG2
VAL
A
268
−53.310
18.121
.103
1.00
15.30
C


ATOM
3963
C
VAL
A
268
−55.262
19.788
−2.736
1.00
17.15
C


ATOM
3964
O
VAL
A
268
−54.748
20.710
−3.350
1.00
17.12
O


ATOM
3966
N
ALA
A
269
−56.217
19.014
−3.243
1.00
17.99
N


ATOM
3967
CA
ALA
A
269
−56.688
19.158
−4.622
1.00
18.79
C


ATOM
3969
CB
ALA
A
269
−55.958
18.183
−5.551
1.00
18.26
C


ATOM
3973
C
ALA
A
269
−58.196
18.938
−4.672
1.00
19.70
C


ATOM
3974
O
ALA
A
269
−58.665
17.834
−4.958
1.00
19.50
O


ATOM
3976
N
PHE
A
270
−58.945
20.011
−4.417
1.00
21.09
N


ATOM
3977
CA
PHE
A
270
−60.393
19.910
−4.211
1.00
22.32
C


ATOM
3979
CB
PHE
A
270
−60.925
21.108
−3.404
1.00
22.49
C


ATOM
3982
CG
PHE
A
270
−61.193
22.321
−4.246
1.00
23.31
C


ATOM
3983
CD1
PHE
A
270
−62.423
22.483
−4.883
1.00
24.16
C


ATOM
3985
CE1
PHE
A
270
−62.662
23.569
−5.683
1.00
23.84
C


ATOM
3987
CZ
PHE
A
270
−61.675
24.497
−5.871
1.00
23.93
C


ATOM
3989
CE2
PHE
A
270
−60.448
24.349
−5.242
1.00
23.33
C


ATOM
3991
CD2
PHE
A
270
−60.213
23.268
−4.443
1.00
23.11
C


ATOM
3993
C
PHE
A
270
−61.173
19.820
−5.515
1.00
23.21
C


ATOM
3994
O
PHE
A
270
−62.142
19.069
−5.599
1.00
23.48
O


ATOM
3996
N
GLU
A
271
−60.771
20.599
−6.522
1.00
24.16
N


ATOM
3997
CA
GLU
A
271
−61.595
20.744
−7.741
1.00
25.01
C


ATOM
3999
CB
GLU
A
271
−61.065
21.863
−8.655
1.00
25.19
C


ATOM
4002
CG
GLU
A
271
−59.563
21.909
−8.794
1.00
27.45
C


ATOM
4005
CD
GLU
A
271
−58.857
22.910
−7.857
1.00
30.03
C


ATOM
4006
OE1
GLU
A
271
−58.905
24.145
−8.147
1.00
29.41
O


ATOM
4007
OE2
GLU
A
271
−58.227
22.431
−6.865
1.00
30.71
O


ATOM
4008
C
GLU
A
271
−61.799
19.391
−8.484
1.00
24.95
C


ATOM
4009
O
GLU
A
271
−60.972
18.480
−8.352
1.00
25.70
O


ATOM
4011
N
PRO
A
272
−62.918
19.242
−9.224
1.00
24.59
N


ATOM
4012
CA
PRO
A
272
−63.399
17.915
−9.656
1.00
24.38
C


ATOM
4014
CB
PRO
A
272
−64.675
18.243
−10.430
1.00
24.25
C


ATOM
4017
CG
PRO
A
272
−65.105
19.536
−9.869
1.00
24.53
C


ATOM
4020
CD
PRO
A
272
−63.855
20.295
−9.639
1.00
24.42
C


ATOM
4023
C
PRO
A
272
−62.475
17.111
−10.549
1.00
24.29
C


ATOM
4024
O
PRO
A
272
−62.406
15.886
−10.410
1.00
24.45
O


ATOM
4025
N
GLN
A
273
−61.777
17.781
−11.462
1.00
24.13
N


ATOM
4026
CA
GLN
A
273
−60.998
17.064
−12.461
1.00
24.13
C


ATOM
4028
CB
GLN
A
273
−60.523
17.983
−13.567
1.00
23.84
C


ATOM
4031
CG
GLN
A
273
−59.556
19.041
−13.117
1.00
24.37
C


ATOM
4034
CD
GLN
A
273
−60.222
20.360
−12.775
1.00
25.22
C


ATOM
4035
OE1
GLN
A
273
−61.392
20.412
−12.367
1.00
25.71
O


ATOM
4036
NE2
GLN
A
273
−59.468
21.441
−12.932
1.00
24.95
N


ATOM
4039
C
GLN
A
273
−59.808
16.327
−11.877
1.00
24.33
C


ATOM
4040
O
GLN
A
273
−59.224
15.486
−12.555
1.00
24.91
O


ATOM
4042
N
TYR
A
274
−59.462
16.607
−10.626
1.00
24.27
N


ATOM
4043
CA
TYR
A
274
−58.211
16.119
−10.067
1.00
24.38
C


ATOM
4045
CB
TYR
A
274
−57.639
17.180
−9.138
1.00
24.36
C


ATOM
4048
CG
TYR
A
274
−57.066
18.398
−9.819
1.00
24.35
C


ATOM
4049
CD1
TYR
A
274
−56.249
18.291
−10.935
1.00
24.13
C


ATOM
4051
CE1
TYR
A
274
−55.716
19.409
−11.542
1.00
23.75
C


ATOM
4053
CZ
TYR
A
274
−55.968
20.646
−11.019
1.00
24.14
C


ATOM
4054
OH
TYR
A
274
−55.431
21.762
−11.597
1.00
24.45
O


ATOM
4056
CE2
TYR
A
274
−56.755
20.780
−9.903
1.00
24.92
C


ATOM
4058
CD2
TYR
A
274
−57.297
19.658
−9.308
1.00
24.74
C


ATOM
4060
C
TYR
A
274
−58.319
14.796
−9.310
1.00
24.63
C


ATOM
4061
O
TYR
A
274
−57.681
14.613
−8.276
1.00
24.47
O


ATOM
4063
N
SER
A
275
−59.097
13.852
−9.821
1.00
25.00
N


ATOM
4064
CA
SER
A
275
−59.254
12.575
−9.116
1.00
25.11
C


ATOM
4066
CB
SER
A
275
−60.244
11.664
−9.842
1.00
25.14
C


ATOM
4069
OG
SER
A
275
−61.537
12.252
−9.852
1.00
25.96
O


ATOM
4071
C
SER
A
275
−57.907
11.885
−8.963
1.00
24.94
C


ATOM
4072
O
SER
A
275
−57.544
11.439
−7.877
1.00
24.57
O


ATOM
4074
N
ASP
A
276
−57.149
11.822
−10.052
1.00
25.01
N


ATOM
4075
CA
ASP
A
276
−55.840
11.187
−9.990
1.00
24.92
C


ATOM
4077
CB
ASP
A
276
−55.102
11.257
−11.324
1.00
25.02
C


ATOM
4080
CG
ASP
A
276
−55.827
10.495
−12.407
1.00
26.27
C


ATOM
4081
OD1
ASP
A
276
−56.372
9.411
−12.080
1.00
26.65
O


ATOM
4082
OD2
ASP
A
276
−55.880
10.991
−13.563
1.00
28.21
O


ATOM
4083
C
ASP
A
276
−55.026
11.798
−8.881
1.00
24.30
C


ATOM
4084
O
ASP
A
276
−54.454
11.064
−8.099
1.00
24.64
O


ATOM
4086
N
CYS
A
277
−55.005
13.124
−8.772
1.00
23.61
N


ATOM
4087
CA
CYS
A
277
−54.210
13.746
−7.715
1.00
22.91
C


ATOM
4089
CB
CYS
A
277
−54.262
15.268
−7.748
1.00
22.83
C


ATOM
4092
SG
CYS
A
277
−53.048
15.994
−6.615
1.00
22.43
S


ATOM
4094
C
CYS
A
277
−54.653
13.251
−6.357
1.00
22.39
C


ATOM
4095
O
CYS
A
277
−53.822
12.833
−5.559
1.00
22.23
O


ATOM
4097
N
ARG
A
278
−55.962
13.262
−6.115
1.00
22.01
N


ATOM
4098
CA
ARG
A
278
−56.519
12.813
−4.829
1.00
21.40
C


ATOM
4100
CB
ARG
A
278
−58.021
13.053
−4.753
1.00
21.07
C


ATOM
4103
CG
ARG
A
278
−58.382
14.509
−4.754
1.00
20.39
C


ATOM
4106
CD
ARG
A
278
−59.852
14.698
−4.527
1.00
20.05
C


ATOM
4109
NE
ARG
A
278
−60.683
14.331
−5.675
1.00
18.86
N


ATOM
4111
CZ
ARG
A
278
−60.993
15.144
−6.679
1.00
18.58
C


ATOM
4112
NH1
ARG
A
278
−60.530
16.391
−6.730
1.00
18.45
N


ATOM
4115
NH2
ARG
A
278
−61.775
14.702
−7.647
1.00
19.04
N


ATOM
4118
C
ARG
A
278
−56.224
11.358
−4.530
1.00
21.12
C


ATOM
4119
O
ARG
A
278
−55.804
11.050
−3.434
1.00
21.59
O


ATOM
4121
N
ASN
A
279
−56.412
10.467
−5.493
1.00
20.94
N


ATOM
4122
CA
ASN
A
279
−56.168
9.044
−5.243
1.00
21.08
C


ATOM
4124
CB
ASN
A
279
−56.672
8.182
−6.401
1.00
21.54
C


ATOM
4127
CG
ASN
A
279
−58.199
8.346
−6.642
1.00
23.94
C


ATOM
4128
OD1
ASN
A
279
−58.920
8.941
−5.823
1.00
26.47
O


ATOM
4129
ND2
ASN
A
279
−58.685
7.825
−7.769
1.00
25.52
N


ATOM
4132
C
ASN
A
279
−54.699
8.798
−4.972
1.00
20.30
C


ATOM
4133
O
ASN
A
279
−54.337
8.200
−3.977
1.00
19.95
O


ATOM
4135
N
SER
A
280
−53.851
9.297
−5.856
1.00
20.02
N


ATOM
4136
CA
SER
A
280
−52.409
9.335
−5.612
1.00
19.32
C


ATOM
4138
CB
SER
A
280
−51.725
10.304
−6.580
1.00
19.35
C


ATOM
4141
OG
SER
A
280
−50.624
9.705
−7.212
1.00
19.77
O


ATOM
4143
C
SER
A
280
−52.122
9.745
−4.166
1.00
18.55
C


ATOM
4144
O
SER
A
280
−51.514
8.976
−3.436
1.00
18.98
O


ATOM
4146
N
VAL
A
281
−52.580
10.923
−3.743
1.00
17.45
N


ATOM
4147
CA
VAL
A
281
−52.235
11.444
−2.416
1.00
17.01
C


ATOM
4149
CB
VAL
A
281
−52.650
12.934
−2.235
1.00
17.20
C


ATOM
4151
CG1
VAL
A
281
−52.492
13.376
−.787
1.00
16.76
C


ATOM
4155
CG2
VAL
A
281
−51.826
13.847
−3.128
1.00
17.13
C


ATOM
4159
C
VAL
A
281
−52.861
10.607
−1.301
1.00
16.82
C


ATOM
4160
O
VAL
A
281
−52.217
10.314
−.289
1.00
16.81
O


ATOM
4162
N
ALA
A
282
−54.118
10.225
−1.481
1.00
16.55
N


ATOM
4163
CA
ALA
A
282
−54.774
9.304
−.559
1.00
16.31
C


ATOM
4165
CB
ALA
A
282
−56.174
8.951
−1.060
1.00
16.08
C


ATOM
4169
C
ALA
A
282
−53.946
8.036
−.355
1.00
16.31
C


ATOM
4170
O
ALA
A
282
−53.671
7.653
.762
1.00
16.16
O


ATOM
4172
N
LYS
A
283
−53.539
7.395
−1.443
1.00
16.92
N


ATOM
4173
CA
LYS
A
283
−52.773
6.139
−1.368
1.00
17.39
C


ATOM
4175
CB
LYS
A
283
−52.454
5.596
−2.773
1.00
17.31
C


ATOM
4178
CG
LYS
A
283
−53.680
5.066
−3.519
1.00
17.85
C


ATOM
4181
CD
LYS
A
283
−53.389
4.527
−4.941
1.00
18.98
C


ATOM
4184
CE
LYS
A
283
−54.709
4.275
−5.718
1.00
19.79
C


ATOM
4187
NZ
LYS
A
283
−54.695
3.091
−6.625
1.00
20.11
N


ATOM
4191
C
LYS
A
283
−51.483
6.338
−.591
1.00
17.82
C


ATOM
4192
O
LYS
A
283
−51.170
5.577
.331
1.00
17.37
O


ATOM
4194
N
MET
A
284
−50.744
7.381
−.964
1.00
18.49
N


ATOM
4195
CA
MET
A
284
−49.434
7.622
−.373
1.00
18.82
C


ATOM
4197
CB
MET
A
284
−48.688
8.795
−1.047
1.00
18.84
C


ATOM
4200
CG
MET
A
284
−48.118
8.506
−2.444
1.00
18.47
C


ATOM
4203
SD
MET
A
284
−47.540
6.819
−2.718
1.00
19.50
S


ATOM
4204
CE
MET
A
284
−49.088
5.982
−3.094
1.00
19.36
C


ATOM
4208
C
MET
A
284
−49.575
7.848
1.115
1.00
18.95
C


ATOM
4209
O
MET
A
284
−48.901
7.166
1.892
1.00
19.29
O


ATOM
4211
N
PHE
A
285
−50.465
8.762
1.507
1.00
18.94
N


ATOM
4212
CA
PHE
A
285
−50.671
9.082
2.930
1.00
19.26
C


ATOM
4214
CB
PHE
A
285
−51.714
10.185
3.073
1.00
19.72
C


ATOM
4217
CG
PHE
A
285
−51.575
11.016
4.328
1.00
21.97
C


ATOM
4218
CD1
PHE
A
285
−50.335
11.202
4.954
1.00
24.49
C


ATOM
4220
CE1
PHE
A
285
−50.209
11.996
6.086
1.00
25.11
C


ATOM
4222
CZ
PHE
A
285
−51.321
12.634
6.597
1.00
26.40
C


ATOM
4224
CE2
PHE
A
285
−52.566
12.470
5.977
1.00
26.44
C


ATOM
4226
CD2
PHE
A
285
−52.678
11.670
4.846
1.00
24.55
C


ATOM
4228
C
PHE
A
285
−51.097
7.879
3.770
1.00
18.74
C


ATOM
4229
O
PHE
A
285
−50.700
7.729
4.924
1.00
18.31
O


ATOM
4231
N
SER
A
286
−51.903
7.019
3.169
1.00
18.49
N


ATOM
4232
CA
SER
A
286
−52.281
5.772
3.791
1.00
18.38
C


ATOM
4234
CB
SER
A
286
−53.302
5.065
2.926
1.00
18.45
C


ATOM
4237
OG
SER
A
286
−54.389
5.949
2.687
1.00
19.82
O


ATOM
4239
C
SER
A
286
−51.070
4.888
4.048
1.00
18.08
C


ATOM
4240
O
SER
A
286
−50.931
4.376
5.146
1.00
18.18
O


ATOM
4242
N
PHE
A
287
−50.195
4.714
3.054
1.00
17.72
N


ATOM
4243
CA
PHE
A
287
−48.911
4.024
3.279
1.00
17.23
C


ATOM
4245
CB
PHE
A
287
−48.133
3.801
1.977
1.00
17.09
C


ATOM
4248
CG
PHE
A
287
−48.513
2.555
1.258
1.00
17.26
C


ATOM
4249
CD1
PHE
A
287
−48.220
1.315
1.802
1.00
18.31
C


ATOM
4251
CE1
PHE
A
287
−48.583
.129
1.131
1.00
18.47
C


ATOM
4253
CZ
PHE
A
287
−49.237
.198
−.091
1.00
17.88
C


ATOM
4255
CE2
PHE
A
287
−49.530
1.441
−.642
1.00
17.57
C


ATOM
4257
CD2
PHE
A
287
−49.168
2.608
.031
1.00
17.79
C


ATOM
4259
C
PHE
A
287
−48.022
4.787
4.277
1.00
16.92
C


ATOM
4260
O
PHE
A
287
−47.369
4.173
5.143
1.00
17.18
O


ATOM
4262
N
VAL
A
288
−47.989
6.113
4.174
1.00
16.00
N


ATOM
4263
CA
VAL
A
288
−47.148
6.883
5.080
1.00
15.45
C


ATOM
4265
CB
VAL
A
288
−47.289
8.399
4.863
1.00
15.21
C


ATOM
4267
CG1
VAL
A
288
−46.433
9.162
5.852
1.00
14.24
C


ATOM
4271
CG2
VAL
A
288
−46.898
8.757
3.450
1.00
14.46
C


ATOM
4275
C
VAL
A
288
−47.479
6.499
6.527
1.00
15.46
C


ATOM
4276
O
VAL
A
288
−46.590
6.160
7.299
1.00
14.79
O


ATOM
4278
N
THR
A
289
−48.759
6.494
6.880
1.00
15.62
N


ATOM
4279
CA
THR
A
289
−49.110
6.272
8.274
1.00
16.09
C


ATOM
4281
CB
THR
A
289
−50.602
6.557
8.588
1.00
15.72
C


ATOM
4283
OG1
THR
A
289
−51.422
5.827
7.708
1.00
16.52
O


ATOM
4285
CG2
THR
A
289
−50.927
8.007
8.371
1.00
16.56
C


ATOM
4289
C
THR
A
289
−48.677
4.879
8.727
1.00
16.34
C


ATOM
4290
O
THR
A
289
−48.234
4.707
9.881
1.00
16.68
O


ATOM
4292
N
ILE
A
290
−48.737
3.904
7.820
1.00
16.29
N


ATOM
4293
CA
ILE
A
290
−48.347
2.538
8.166
1.00
16.56
C


ATOM
4295
CB
ILE
A
290
−48.734
1.516
7.096
1.00
16.48
C


ATOM
4297
CG1
ILE
A
290
−50.247
1.440
6.944
1.00
16.91
C


ATOM
4300
CD1
ILE
A
290
−50.677
.564
5.811
1.00
16.52
C


ATOM
4304
CG2
ILE
A
290
−48.262
.145
7.488
1.00
16.52
C


ATOM
4308
C
ILE
A
290
−46.842
2.456
8.402
1.00
16.94
C


ATOM
4309
O
ILE
A
290
−46.404
1.968
9.443
1.00
17.06
O


ATOM
4311
N
ILE
A
291
−46.048
2.942
7.451
1.00
17.22
N


ATOM
4312
CA
ILE
A
291
−44.595
2.969
7.640
1.00
17.20
C


ATOM
4314
CB
ILE
A
291
−43.842
3.534
6.405
1.00
17.32
C


ATOM
4316
CG1
ILE
A
291
−44.172
2.744
5.125
1.00
17.61
C


ATOM
4319
CD1
ILE
A
291
−44.004
1.265
5.250
1.00
18.21
C


ATOM
4323
CG2
ILE
A
291
−42.336
3.550
6.637
1.00
16.64
C


ATOM
4327
C
ILE
A
291
−44.262
3.794
8.886
1.00
17.36
C


ATOM
4328
O
ILE
A
291
−43.420
3.413
9.670
1.00
17.06
O


ATOM
4330
N
ASP
A
292
−44.950
4.906
9.093
1.00
18.12
N


ATOM
4331
CA
ASP
A
292
−44.627
5.755
10.227
1.00
18.83
C


ATOM
4333
CB
ASP
A
292
−45.511
7.017
10.285
1.00
19.22
C


ATOM
4336
CG
ASP
A
292
−45.185
7.920
11.485
1.00
19.93
C


ATOM
4337
OD1
ASP
A
292
−44.062
8.460
11.544
1.00
21.80
O


ATOM
4338
OD2
ASP
A
292
−46.048
8.080
12.375
1.00
20.46
O


ATOM
4339
C
ASP
A
292
−44.745
4.947
11.509
1.00
18.96
C


ATOM
4340
O
ASP
A
292
−43.902
5.094
12.394
1.00
19.05
O


ATOM
4342
N
ASP
A
293
−45.774
4.097
11.610
1.00
19.05
N


ATOM
4343
CA
ASP
A
293
−45.951
3.273
12.817
1.00
18.99
C


ATOM
4345
CB
ASP
A
293
−47.237
2.443
12.790
1.00
18.95
C


ATOM
4348
CG
ASP
A
293
−48.496
3.272
12.921
1.00
19.27
C


ATOM
4349
OD1
ASP
A
293
−48.483
4.361
13.523
1.00
21.51
O


ATOM
4350
OD2
ASP
A
293
−49.536
2.812
12.421
1.00
19.61
O


ATOM
4351
C
ASP
A
293
−44.783
2.322
12.935
1.00
19.07
C


ATOM
4352
O
ASP
A
293
−44.244
2.135
14.024
1.00
19.35
O


ATOM
4354
N
ILE
A
294
−44.390
1.730
11.805
1.00
19.10
N


ATOM
4355
CA
ILE
A
294
−43.320
.727
11.786
1.00
19.04
C


ATOM
4357
CB
ILE
A
294
−43.137
.109
10.386
1.00
18.49
C


ATOM
4359
CG1
ILE
A
294
−44.343
−.754
10.038
1.00
17.60
C


ATOM
4362
CD1
ILE
A
294
−44.204
−1.504
8.752
1.00
16.77
C


ATOM
4366
CG2
ILE
A
294
−41.895
−.745
10.348
1.00
18.77
C


ATOM
4370
C
ILE
A
294
−41.974
1.273
12.298
1.00
19.55
C


ATOM
4371
O
ILE
A
294
−41.234
.550
12.974
1.00
19.75
O


ATOM
4373
N
TYR
A
295
−41.649
2.525
11.983
1.00
19.75
N


ATOM
4374
CA
TYR
A
295
−40.411
3.103
12.476
1.00
19.91
C


ATOM
4376
CB
TYR
A
295
−39.856
4.178
11.542
1.00
19.66
C


ATOM
4379
CG
TYR
A
295
−39.206
3.695
10.245
1.00
18.19
C


ATOM
4380
CD1
TYR
A
295
−37.821
3.727
10.075
1.00
16.19
C


ATOM
4382
CE1
TYR
A
295
−37.222
3.331
8.882
1.00
14.68
C


ATOM
4384
CZ
TYR
A
295
−38.004
2.906
7.828
1.00
15.04
C


ATOM
4385
OH
TYR
A
295
−37.428
2.485
6.631
1.00
12.25
O


ATOM
4387
CE2
TYR
A
295
−39.383
2.871
7.975
1.00
16.48
C


ATOM
4389
CD2
TYR
A
295
−39.975
3.271
9.172
1.00
17.01
C


ATOM
4391
C
TYR
A
295
−40.647
3.677
13.858
1.00
20.73
C


ATOM
4392
O
TYR
A
295
−39.749
3.635
14.717
1.00
21.64
O


ATOM
4394
N
ASP
A
296
−41.843
4.200
14.103
1.00
21.38
N


ATOM
4395
CA
ASP
A
296
−42.100
4.865
15.391
1.00
22.20
C


ATOM
4397
CB
ASP
A
296
−43.421
5.644
15.391
1.00
22.69
C


ATOM
4400
CG
ASP
A
296
−43.567
6.548
16.607
1.00
23.85
C


ATOM
4401
OD1
ASP
A
296
−42.568
7.179
17.014
1.00
25.49
O


ATOM
4402
OD2
ASP
A
296
−44.689
6.648
17.145
1.00
26.12
O


ATOM
4403
C
ASP
A
296
−42.106
3.890
16.549
1.00
22.10
C


ATOM
4404
O
ASP
A
296
−41.376
4.082
17.506
1.00
22.14
O


ATOM
4406
N
VAL
A
297
−42.900
2.828
16.435
1.00
22.25
N


ATOM
4407
CA
VAL
A
297
−43.163
1.937
17.570
1.00
22.22
C


ATOM
4409
CB
VAL
A
297
−44.635
2.116
18.057
1.00
22.07
C


ATOM
4411
CG1
VAL
A
297
−44.958
3.587
18.215
1.00
21.63
C


ATOM
4415
CG2
VAL
A
297
−45.618
1.459
17.099
1.00
20.76
C


ATOM
4419
C
VAL
A
297
−42.861
.422
17.373
1.00
22.49
C


ATOM
4420
O
VAL
A
297
−42.517
−.255
18.343
1.00
22.40
O


ATOM
4422
N
TYR
A
298
−42.990
−.117
16.157
1.00
22.69
N


ATOM
4423
CA
TYR
A
298
−43.065
−1.579
15.993
1.00
22.90
C


ATOM
4425
CB
TYR
A
298
−44.089
−1.974
14.934
1.00
22.77
C


ATOM
4428
CG
TYR
A
298
−44.341
−3.469
14.932
1.00
23.74
C


ATOM
4429
CD1
TYR
A
298
−45.249
−4.043
15.819
1.00
25.72
C


ATOM
4431
CE1
TYR
A
298
−45.484
−5.435
15.833
1.00
26.12
C


ATOM
4433
CZ
TYR
A
298
−44.798
−6.247
14.954
1.00
25.59
C


ATOM
4434
OH
TYR
A
298
−45.027
−7.593
14.970
1.00
25.33
O


ATOM
4436
CE2
TYR
A
298
−43.890
−5.702
14.062
1.00
24.79
C


ATOM
4438
CD2
TYR
A
298
−43.661
−4.317
14.061
1.00
24.20
C


ATOM
4440
C
TYR
A
298
−41.750
−2.258
15.649
1.00
23.02
C


ATOM
4441
O
TYR
A
298
−41.387
−3.257
16.256
1.00
22.80
O


ATOM
4443
N
GLY
A
299
−41.069
−1.747
14.634
1.00
23.47
N


ATOM
4444
CA
GLY
A
299
−39.839
−2.361
14.149
1.00
23.36
C


ATOM
4447
C
GLY
A
299
−38.631
−1.978
14.984
1.00
23.27
C


ATOM
4448
O
GLY
A
299
−38.532
−.858
15.501
1.00
23.35
O


ATOM
4450
N
THR
A
300
−37.702
−2.918
15.098
1.00
23.11
N


ATOM
4451
CA
THR
A
300
−36.459
−2.682
15.797
1.00
22.90
C


ATOM
4453
CB
THR
A
300
−35.869
−3.957
16.386
1.00
22.83
C


ATOM
4455
OG1
THR
A
300
−35.328
−4.756
15.328
1.00
22.61
O


ATOM
4457
CG2
THR
A
300
−36.928
−4.732
17.162
1.00
22.18
C


ATOM
4461
C
THR
A
300
−35.482
−2.120
14.796
1.00
23.00
C


ATOM
4462
O
THR
A
300
−35.606
−2.364
13.602
1.00
23.13
O


ATOM
4464
N
LEU
A
301
−34.496
−1.394
15.309
1.00
23.07
N


ATOM
4465
CA
LEU
A
301
−33.596
−.572
14.498
1.00
22.84
C


ATOM
4467
CB
LEU
A
301
−32.515
.007
15.403
1.00
22.80
C


ATOM
4470
CG
LEU
A
301
−31.965
1.412
15.182
1.00
22.39
C


ATOM
4472
CD1
LEU
A
301
−32.983
2.365
14.587
1.00
22.44
C


ATOM
4476
CD2
LEU
A
301
−31.482
1.919
16.536
1.00
22.19
C


ATOM
4480
C
LEU
A
301
−32.964
−1.358
13.361
1.00
22.95
C


ATOM
4481
O
LEU
A
301
−32.910
−.888
12.232
1.00
22.50
O


ATOM
4483
N
ASP
A
302
−32.511
−2.569
13.673
1.00
23.35
N


ATOM
4484
CA
ASP
A
302
−31.929
−3.469
12.670
1.00
23.65
C


ATOM
4486
CB
ASP
A
302
−31.332
−4.747
13.328
1.00
24.12
C


ATOM
4489
CG
ASP
A
302
−29.984
−4.498
14.057
1.00
25.23
C


ATOM
4490
OD1
ASP
A
302
−29.003
−4.051
13.409
1.00
26.43
O


ATOM
4491
OD2
ASP
A
302
−29.896
−4.780
15.277
1.00
26.92
O


ATOM
4492
C
ASP
A
302
−32.945
−3.859
11.581
1.00
23.11
C


ATOM
4493
O
ASP
A
302
−32.544
−4.086
10.445
1.00
23.05
O


ATOM
4495
N
GLU
A
303
−34.235
−3.965
11.927
1.00
22.63
N


ATOM
4496
CA
GLU
A
303
−35.295
−4.248
10.931
1.00
22.40
C


ATOM
4498
CB
GLU
A
303
−36.625
−4.675
11.589
1.00
22.20
C


ATOM
4501
CG
GLU
A
303
−36.537
−5.956
12.426
1.00
22.66
C


ATOM
4504
CD
GLU
A
303
−37.832
−6.341
13.159
1.00
22.69
C


ATOM
4505
OE1
GLU
A
303
−38.614
−5.449
13.568
1.00
22.23
O


ATOM
4506
OE2
GLU
A
303
−38.051
−7.558
13.338
1.00
21.64
O


ATOM
4507
C
GLU
A
303
−35.533
−3.017
10.067
1.00
22.35
C


ATOM
4508
O
GLU
A
303
−35.658
−3.105
8.841
1.00
22.27
O


ATOM
4510
N
LEU
A
304
−35.597
−1.866
10.724
1.00
22.34
N


ATOM
4511
CA
LEU
A
304
−35.776
−.607
10.040
1.00
22.26
C


ATOM
4513
CB
LEU
A
304
−35.861
.537
11.052
1.00
22.49
C


ATOM
4516
CG
LEU
A
304
−37.089
.517
11.973
1.00
23.05
C


ATOM
4518
CD1
LEU
A
304
−37.109
1.708
12.932
1.00
23.46
C


ATOM
4522
CD2
LEU
A
304
−38.353
.511
11.142
1.00
23.96
C


ATOM
4526
C
LEU
A
304
−34.634
−.383
9.063
1.00
22.09
C


ATOM
4527
O
LEU
A
304
−34.873
.094
7.969
1.00
22.32
O


ATOM
4529
N
GLU
A
305
−33.408
−.740
9.450
1.00
21.91
N


ATOM
4530
CA
GLU
A
305
−32.259
−.685
8.541
1.00
21.93
C


ATOM
4532
CB
GLU
A
305
−30.988
−1.194
9.219
1.00
22.35
C


ATOM
4535
CG
GLU
A
305
−30.363
−.258
10.249
1.00
24.12
C


ATOM
4538
CD
GLU
A
305
−29.751
1.002
9.649
1.00
26.11
C


ATOM
4539
OE1
GLU
A
305
−29.275
1.846
10.454
1.00
25.68
O


ATOM
4540
OE2
GLU
A
305
−29.756
1.146
8.391
1.00
27.67
O


ATOM
4541
C
GLU
A
305
−32.475
−1.524
7.295
1.00
21.54
C


ATOM
4542
O
GLU
A
305
−32.010
−1.162
6.220
1.00
21.75
O


ATOM
4544
N
LEU
A
306
−33.155
−2.660
7.448
1.00
21.21
N


ATOM
4545
CA
LEU
A
306
−33.459
−3.557
6.316
1.00
20.66
C


ATOM
4547
CB
LEU
A
306
−33.880
−4.956
6.795
1.00
20.26
C


ATOM
4550
CG
LEU
A
306
−32.725
−5.854
7.220
1.00
19.57
C


ATOM
4552
CD1
LEU
A
306
−33.261
−7.150
7.777
1.00
20.18
C


ATOM
4556
CD2
LEU
A
306
−31.791
−6.120
6.061
1.00
18.29
C


ATOM
4560
C
LEU
A
306
−34.535
−2.967
5.416
1.00
20.23
C


ATOM
4561
O
LEU
A
306
−34.412
−2.966
4.197
1.00
19.97
O


ATOM
4563
N
PHE
A
307
−35.588
−2.457
6.023
1.00
19.99
N


ATOM
4564
CA
PHE
A
307
−36.635
−1.861
5.237
1.00
20.00
C


ATOM
4566
CB
PHE
A
307
−37.771
−1.388
6.118
1.00
20.08
C


ATOM
4569
CG
PHE
A
307
−39.011
−1.115
5.370
1.00
19.05
C


ATOM
4570
CD1
PHE
A
307
−39.895
−2.118
5.119
1.00
18.77
C


ATOM
4572
CE1
PHE
A
307
−41.037
−1.873
4.421
1.00
20.07
C


ATOM
4574
CZ
PHE
A
307
−41.296
−.621
3.959
1.00
19.63
C


ATOM
4576
CE2
PHE
A
307
−40.411
.391
4.199
1.00
19.27
C


ATOM
4578
CD2
PHE
A
307
−39.278
.142
4.900
1.00
19.17
C


ATOM
4580
C
PHE
A
307
−36.087
−.695
4.447
1.00
20.25
C


ATOM
4581
O
PHE
A
307
−36.356
−.589
3.242
1.00
20.08
O


ATOM
4583
N
THR
A
308
−35.325
.167
5.137
1.00
20.51
N


ATOM
4584
CA
THR
A
308
−34.737
1.379
4.538
1.00
20.60
C


ATOM
4586
CB
THR
A
308
−33.860
2.177
5.541
1.00
20.41
C


ATOM
4588
OG1
THR
A
308
−34.672
2.661
6.611
1.00
20.05
O


ATOM
4590
CG2
THR
A
308
−33.198
3.376
4.864
1.00
20.38
C


ATOM
4594
C
THR
A
308
−33.895
1.009
3.331
1.00
20.82
C


ATOM
4595
O
THR
A
308
−34.057
1.571
2.243
1.00
20.45
O


ATOM
4597
N
ASP
A
309
−33.020
.031
3.522
1.00
21.32
N


ATOM
4598
CA
ASP
A
309
−32.138
−.399
2.449
1.00
21.88
C


ATOM
4600
CB
ASP
A
309
−31.042
−1.324
2.971
1.00
22.44
C


ATOM
4603
CG
ASP
A
309
−30.164
−1.847
1.857
1.00
25.69
C


ATOM
4604
OD1
ASP
A
309
−29.599
−1.010
1.089
1.00
28.02
O


ATOM
4605
OD2
ASP
A
309
−30.076
−3.100
1.730
1.00
30.59
O


ATOM
4606
C
ASP
A
309
−32.928
−1.085
1.357
1.00
21.17
C


ATOM
4607
O
ASP
A
309
−32.601
−.948
.188
1.00
20.95
O


ATOM
4609
N
ALA
A
310
−33.965
−1.818
1.757
1.00
20.99
N


ATOM
4610
CA
ALA
A
310
−34.885
−2.474
.828
1.00
20.91
C


ATOM
4612
CB
ALA
A
310
−35.931
−3.244
1.591
1.00
20.77
C


ATOM
4616
C
ALA
A
310
−35.567
−1.501
−.123
1.00
21.08
C


ATOM
4617
O
ALA
A
310
−35.745
−1.816
−1.305
1.00
20.76
O


ATOM
4619
N
VAL
A
311
−35.958
−.334
.402
1.00
21.51
N


ATOM
4620
CA
VAL
A
311
−36.594
.719
−.396
1.00
21.50
C


ATOM
4622
CB
VAL
A
311
−37.424
1.715
.477
1.00
21.73
C


ATOM
4624
CG1
VAL
A
311
−38.724
1.076
.941
1.00
21.01
C


ATOM
4628
CG2
VAL
A
311
−37.765
2.993
−.292
1.00
21.88
C


ATOM
4632
C
VAL
A
311
−35.553
1.445
−1.230
1.00
21.67
C


ATOM
4633
O
VAL
A
311
−35.811
1.728
−2.389
1.00
21.71
O


ATOM
4635
N
GLU
A
312
−34.381
1.724
−.663
1.00
22.25
N


ATOM
4636
CA
GLU
A
312
−33.248
2.284
−1.443
1.00
23.00
C


ATOM
4638
CB
GLU
A
312
−31.951
2.331
−.608
1.00
23.36
C


ATOM
4641
CG
GLU
A
312
−31.897
3.383
.511
1.00
24.72
C


ATOM
4644
CD
GLU
A
312
−30.526
3.469
1.189
1.00
27.09
C


ATOM
4645
OE1
GLU
A
312
−30.083
4.608
1.458
1.00
30.07
O


ATOM
4646
OE2
GLU
A
312
−29.885
2.418
1.454
1.00
27.86
O


ATOM
4647
C
GLU
A
312
−32.954
1.498
−2.731
1.00
23.13
C


ATOM
4648
O
GLU
A
312
−32.851
2.064
−3.803
1.00
22.88
O


ATOM
4650
N
ARG
A
313
−32.819
.188
−2.615
1.00
23.74
N


ATOM
4651
CA
ARG
A
313
−32.400
−.628
−3.743
1.00
24.46
C


ATOM
4653
CB
ARG
A
313
−31.758
−1.916
−3.232
1.00
25.01
C


ATOM
4656
CG
ARG
A
313
−30.421
−1.667
−2.481
1.00
27.74
C


ATOM
4659
CD
ARG
A
313
−29.715
−2.963
−2.072
1.00
31.41
C


ATOM
4662
NE
ARG
A
313
−30.675
−3.921
−1.499
1.00
34.94
N


ATOM
4664
CZ
ARG
A
313
−31.203
−4.974
−2.138
1.00
37.87
C


ATOM
4665
NH1
ARG
A
313
−30.861
−5.282
−3.402
1.00
38.35
N


ATOM
4668
NH2
ARG
A
313
−32.079
−5.746
−1.495
1.00
38.82
N


ATOM
4671
C
ARG
A
313
−33.523
−.914
−4.739
1.00
24.27
C


ATOM
4672
O
ARG
A
313
−33.257
−1.178
−5.898
1.00
24.17
O


ATOM
4674
N
TRP
A
314
−34.770
−.873
−4.282
1.00
24.59
N


ATOM
4675
CA
TRP
A
314
−35.939
−1.042
−5.142
1.00
24.66
C


ATOM
4677
CB
TRP
A
314
−36.175
.234
−5.961
1.00
24.39
C


ATOM
4680
CG
TRP
A
314
−37.575
.382
−6.386
1.00
22.61
C


ATOM
4681
CD1
TRP
A
314
−38.073
.204
−7.635
1.00
21.66
C


ATOM
4683
NE1
TRP
A
314
−39.429
.403
−7.634
1.00
21.42
N


ATOM
4685
CE2
TRP
A
314
−39.829
.707
−6.360
1.00
20.99
C


ATOM
4686
CD2
TRP
A
314
−38.683
.701
−5.550
1.00
21.41
C


ATOM
4687
CE3
TRP
A
314
−38.817
.991
−4.191
1.00
21.48
C


ATOM
4689
CZ3
TRP
A
314
−40.080
1.277
−3.693
1.00
21.38
C


ATOM
4691
CH2
TRP
A
314
−41.204
1.269
−4.523
1.00
20.84
C


ATOM
4693
CZ2
TRP
A
314
−41.099
.985
−5.857
1.00
20.87
C


ATOM
4695
C
TRP
A
314
−35.831
−2.286
−6.038
1.00
25.65
C


ATOM
4696
O
TRP
A
314
−36.069
−2.238
−7.259
1.00
25.69
O


ATOM
4698
N
ASP
A
315
−35.480
−3.400
−5.404
1.00
26.79
N


ATOM
4699
CA
ASP
A
315
−35.253
−4.667
−6.087
1.00
28.01
C


ATOM
4701
CB
ASP
A
315
−33.801
−5.097
−5.890
1.00
28.07
C


ATOM
4704
CG
ASP
A
315
−33.553
−6.536
−6.296
1.00
29.92
C


ATOM
4705
OD1
ASP
A
315
−34.262
−7.026
−7.197
1.00
32.58
O


ATOM
4706
OD2
ASP
A
315
−32.648
−7.194
−5.722
1.00
32.73
O


ATOM
4707
C
ASP
A
315
−36.202
−5.710
−5.518
1.00
28.91
C


ATOM
4708
O
ASP
A
315
−36.019
−6.163
−4.399
1.00
29.17
O


ATOM
4710
N
VAL
A
316
−37.218
−6.091
−6.283
1.00
30.25
N


ATOM
4711
CA
VAL
A
316
−38.233
−7.012
−5.778
1.00
31.47
C


ATOM
4713
CB
VAL
A
316
−39.396
−7.156
−6.755
1.00
31.56
C


ATOM
4715
CG1
VAL
A
316
−40.668
−7.590
−6.027
1.00
30.99
C


ATOM
4719
CG2
VAL
A
316
−39.033
−8.141
−7.862
1.00
31.84
C


ATOM
4723
C
VAL
A
316
−37.663
−8.405
−5.540
1.00
32.86
C


ATOM
4724
O
VAL
A
316
−38.170
−9.153
−4.708
1.00
32.99
O


ATOM
4726
N
ASN
A
317
−36.607
−8.750
−6.278
1.00
34.55
N


ATOM
4727
CA
ASN
A
317
−35.940
−10.060
−6.160
1.00
35.53
C


ATOM
4729
CB
ASN
A
317
−35.013
−10.298
−7.367
1.00
35.68
C


ATOM
4732
CG
ASN
A
317
−35.752
−10.264
−8.713
1.00
35.92
C


ATOM
4733
OD1
ASN
A
317
−36.634
−11.092
−8.971
1.00
36.95
O


ATOM
4734
ND2
ASN
A
317
−35.368
−9.323
−9.585
1.00
34.17
N


ATOM
4737
C
ASN
A
317
−35.126
−10.225
−4.871
1.00
36.40
C


ATOM
4738
O
ASN
A
317
−34.385
−11.195
−4.747
1.00
36.47
O


ATOM
4740
N
ALA
A
318
−35.239
−9.265
−3.944
1.00
37.52
N


ATOM
4741
CA
ALA
A
318
−34.614
−9.335
−2.613
1.00
38.45
C


ATOM
4743
CB
ALA
A
318
−33.371
−8.465
−2.557
1.00
38.43
C


ATOM
4747
C
ALA
A
318
−35.631
−8.902
−1.554
1.00
39.28
C


ATOM
4748
O
ALA
A
318
−35.361
−8.094
−.662
1.00
39.55
O


ATOM
4750
N
ILE
A
319
−36.823
−9.456
−1.698
1.00
40.17
N


ATOM
4751
CA
ILE
A
319
−37.905
−9.310
−.740
1.00
40.49
C


ATOM
4753
CB
ILE
A
319
−39.275
−9.588
−1.469
1.00
40.64
C


ATOM
4755
CG1
ILE
A
319
−40.473
−9.078
−.683
1.00
40.88
C


ATOM
4758
CD1
ILE
A
319
−41.799
−9.535
−1.280
1.00
40.86
C


ATOM
4762
CG2
ILE
A
319
−39.460
−11.082
−1.801
1.00
40.50
C


ATOM
4766
C
ILE
A
319
−37.656
−10.319
.393
1.00
40.69
C


ATOM
4767
O
ILE
A
319
−38.136
−10.138
1.504
1.00
40.88
O


ATOM
4769
N
ASN
A
320
−36.886
−11.374
.104
1.00
40.79
N


ATOM
4770
CA
ASN
A
320
−36.689
−12.483
1.049
1.00
40.64
C


ATOM
4772
CB
ASN
A
320
−36.240
−13.761
.314
1.00
40.73
C


ATOM
4775
CG
ASN
A
320
−37.370
−14.422
−.468
1.00
40.98
C


ATOM
4776
OD1
ASN
A
320
−38.556
−14.309
−.119
1.00
40.77
O


ATOM
4777
ND2
ASN
A
320
−37.001
−15.131
−1.529
1.00
41.31
N


ATOM
4780
C
ASN
A
320
−35.711
−12.175
2.169
1.00
40.16
C


ATOM
4781
O
ASN
A
320
−35.546
−12.978
3.077
1.00
40.15
O


ATOM
4783
N
ASP
A
321
−35.067
−11.017
2.101
1.00
39.66
N


ATOM
4784
CA
ASP
A
321
−34.111
−10.615
3.126
1.00
39.51
C


ATOM
4786
CB
ASP
A
321
−33.114
−9.571
2.575
1.00
40.17
C


ATOM
4789
CG
ASP
A
321
−32.595
−9.904
1.152
1.00
42.12
C


ATOM
4790
OD1
ASP
A
321
−32.425
−11.115
.820
1.00
44.15
O


ATOM
4791
OD2
ASP
A
321
−32.354
−8.934
.375
1.00
43.28
O


ATOM
4792
C
ASP
A
321
−34.851
−10.030
4.337
1.00
38.27
C


ATOM
4793
O
ASP
A
321
−34.304
−9.987
5.443
1.00
38.15
O


ATOM
4795
N
LEU
A
322
−36.089
−9.583
4.108
1.00
36.72
N


ATOM
4796
CA
LEU
A
322
−36.887
−8.875
5.104
1.00
35.38
C


ATOM
4798
CB
LEU
A
322
−37.894
−7.942
4.422
1.00
35.15
C


ATOM
4801
CG
LEU
A
322
−37.370
−6.840
3.503
1.00
34.83
C


ATOM
4803
CD1
LEU
A
322
−38.479
−6.286
2.626
1.00
34.45
C


ATOM
4807
CD2
LEU
A
322
−36.742
−5.740
4.316
1.00
34.89
C


ATOM
4811
C
LEU
A
322
−37.683
−9.834
5.963
1.00
34.57
C


ATOM
4812
O
LEU
A
322
−37.975
−10.933
5.527
1.00
34.27
O


ATOM
4814
N
PRO
A
323
−38.039
−9.402
7.189
1.00
33.93
N


ATOM
4815
CA
PRO
A
323
−39.070
−9.917
8.067
1.00
33.49
C


ATOM
4817
CB
PRO
A
323
−39.151
−8.840
9.141
1.00
33.31
C


ATOM
4820
CG
PRO
A
323
−37.791
−8.419
9.311
1.00
33.67
C


ATOM
4823
CD
PRO
A
323
−37.154
−8.496
7.941
1.00
34.20
C


ATOM
4826
C
PRO
A
323
−40.429
−10.036
7.425
1.00
33.33
C


ATOM
4827
O
PRO
A
323
−40.776
−9.232
6.579
1.00
33.35
O


ATOM
4828
N
ASP
A
324
−41.209
−11.005
7.891
1.00
33.37
N


ATOM
4829
CA
ASP
A
324
−42.511
−11.329
7.313
1.00
33.36
C


ATOM
4831
CB
ASP
A
324
−43.137
−12.542
8.037
1.00
33.59
C


ATOM
4834
CG
ASP
A
324
−42.496
−13.881
7.619
1.00
34.18
C


ATOM
4835
OD1
ASP
A
324
−41.885
−13.915
6.518
1.00
36.44
O


ATOM
4836
OD2
ASP
A
324
−42.607
−14.887
8.371
1.00
32.19
O


ATOM
4837
C
ASP
A
324
−43.484
−10.149
7.289
1.00
32.90
C


ATOM
4838
O
ASP
A
324
−44.108
−9.885
6.255
1.00
33.36
O


ATOM
4840
N
TYR
A
325
−43.606
−9.423
8.392
1.00
32.10
N


ATOM
4841
CA
TYR
A
325
−44.515
−8.279
8.400
1.00
31.65
C


ATOM
4843
CB
TYR
A
325
−44.718
−7.726
9.815
1.00
31.68
C


ATOM
4846
CG
TYR
A
325
−43.618
−6.846
10.352
1.00
31.35
C


ATOM
4847
CD1
TYR
A
325
−42.507
−7.389
10.992
1.00
31.31
C


ATOM
4849
CE1
TYR
A
325
−41.497
−6.574
11.504
1.00
31.46
C


ATOM
4851
CZ
TYR
A
325
−41.613
−5.192
11.392
1.00
32.41
C


ATOM
4852
OH
TYR
A
325
−40.637
−4.336
11.893
1.00
32.78
O


ATOM
4854
CE2
TYR
A
325
−42.723
−4.644
10.769
1.00
32.17
C


ATOM
4856
CD2
TYR
A
325
−43.713
−5.470
10.261
1.00
31.47
C


ATOM
4858
C
TYR
A
325
−44.094
−7.179
7.424
1.00
31.17
C


ATOM
4859
O
TYR
A
325
−44.947
−6.458
6.920
1.00
31.09
O


ATOM
4861
N
MET
A
326
−42.796
−7.068
7.145
1.00
30.73
N


ATOM
4862
CA
MET
A
326
−42.277
−6.036
6.225
1.00
30.49
C


ATOM
4864
CB
MET
A
326
−40.832
−5.702
6.565
1.00
30.16
C


ATOM
4867
CG
MET
A
326
−40.725
−4.918
7.830
1.00
29.57
C


ATOM
4870
SD
MET
A
326
−39.057
−4.376
8.166
1.00
28.39
S


ATOM
4871
CE
MET
A
326
−39.407
−2.787
8.933
1.00
26.18
C


ATOM
4875
C
MET
A
326
−42.371
−6.418
4.748
1.00
30.59
C


ATOM
4876
O
MET
A
326
−42.786
−5.603
3.920
1.00
30.48
O


ATOM
4878
N
LYS
A
327
−41.936
−7.643
4.438
1.00
30.68
N


ATOM
4879
CA
LYS
A
327
−42.170
−8.299
3.143
1.00
30.56
C


ATOM
4881
CB
LYS
A
327
−42.267
−9.830
3.326
1.00
30.84
C


ATOM
4884
CG
LYS
A
327
−41.052
−10.607
2.844
1.00
32.35
C


ATOM
4887
CD
LYS
A
327
−40.990
−12.019
3.412
1.00
34.43
C


ATOM
4890
CE
LYS
A
327
−40.221
−12.941
2.462
1.00
35.77
C


ATOM
4893
NZ
LYS
A
327
−39.691
−14.162
3.150
1.00
37.20
N


ATOM
4897
C
LYS
A
327
−43.453
−7.811
2.515
1.00
29.89
C


ATOM
4898
O
LYS
A
327
−43.447
−7.220
1.436
1.00
29.85
O


ATOM
4900
N
LEU
A
328
−44.544
−8.046
3.230
1.00
29.10
N


ATOM
4901
CA
LEU
A
328
−45.871
−7.781
2.730
1.00
28.77
C


ATOM
4903
CB
LEU
A
328
−46.899
−8.336
3.709
1.00
28.81
C


ATOM
4906
CG
LEU
A
328
−48.349
−8.364
3.257
1.00
28.82
C


ATOM
4908
CD1
LEU
A
328
−48.519
−9.260
2.046
1.00
29.09
C


ATOM
4912
CD2
LEU
A
328
−49.202
−8.845
4.411
1.00
29.16
C


ATOM
4916
C
LEU
A
328
−46.057
−6.291
2.564
1.00
28.61
C


ATOM
4917
O
LEU
A
328
−46.582
−5.828
1.554
1.00
29.00
O


ATOM
4919
N
CYS
A
329
−45.612
−5.532
3.557
1.00
28.24
N


ATOM
4920
CA
CYS
A
329
−45.737
−4.086
3.504
1.00
27.95
C


ATOM
4922
CB
CYS
A
329
−45.311
−3.459
4.834
1.00
28.21
C


ATOM
4925
SG
CYS
A
329
−45.280
−1.630
4.817
1.00
32.39
S


ATOM
4927
C
CYS
A
329
−44.921
−3.541
2.327
1.00
26.34
C


ATOM
4928
O
CYS
A
329
−45.459
−2.853
1.475
1.00
26.23
O


ATOM
4930
N
PHE
A
330
−43.642
−3.882
2.269
1.00
24.82
N


ATOM
4931
CA
PHE
A
330
−42.790
−3.514
1.130
1.00
23.82
C


ATOM
4933
CB
PHE
A
330
−41.397
−4.137
1.283
1.00
23.64
C


ATOM
4936
CG
PHE
A
330
−40.492
−3.873
.117
1.00
22.63
C


ATOM
4937
CD1
PHE
A
330
−39.845
−2.658
−.008
1.00
21.68
C


ATOM
4939
CE1
PHE
A
330
−39.020
−2.393
−1.082
1.00
21.07
C


ATOM
4941
CZ
PHE
A
330
−38.829
−3.343
−2.046
1.00
22.00
C


ATOM
4943
CE2
PHE
A
330
−39.474
−4.568
−1.944
1.00
22.60
C


ATOM
4945
CD2
PHE
A
330
−40.309
−4.824
−.865
1.00
22.36
C


ATOM
4947
C
PHE
A
330
−43.348
−3.863
−.281
1.00
22.99
C


ATOM
4948
O
PHE
A
330
−43.350
−3.012
−1.182
1.00
22.98
O


ATOM
4950
N
LEU
A
331
−43.789
−5.101
−.492
1.00
21.65
N


ATOM
4951
CA
LEU
A
331
−44.306
−5.484
−1.816
1.00
20.74
C


ATOM
4953
CB
LEU
A
331
−44.573
−6.990
−1.912
1.00
20.57
C


ATOM
4956
CG
LEU
A
331
−44.959
−7.575
−3.277
1.00
19.82
C


ATOM
4958
CD1
LEU
A
331
−43.936
−7.246
−4.329
1.00
19.00
C


ATOM
4962
CD2
LEU
A
331
−45.128
−9.092
−3.165
1.00
19.11
C


ATOM
4966
C
LEU
A
331
−45.568
−4.710
−2.159
1.00
19.98
C


ATOM
4967
O
LEU
A
331
−45.753
−4.324
−3.300
1.00
20.15
O


ATOM
4969
N
ALA
A
332
−46.431
−4.495
−1.172
1.00
19.09
N


ATOM
4970
CA
ALA
A
332
−47.619
−3.675
−1.353
1.00
18.46
C


ATOM
4972
CB
ALA
A
332
−48.406
−3.587
−.045
1.00
18.20
C


ATOM
4976
C
ALA
A
332
−47.248
−2.279
−1.856
1.00
17.91
C


ATOM
4977
O
ALA
A
332
−47.890
−1.745
−2.744
1.00
17.98
O


ATOM
4979
N
LEU
A
333
−46.197
−1.706
−1.295
1.00
17.62
N


ATOM
4980
CA
LEU
A
333
−45.753
−.353
−1.637
1.00
17.60
C


ATOM
4982
CB
LEU
A
333
−44.725
.132
−.598
1.00
17.59
C


ATOM
4985
CG
LEU
A
333
−44.122
1.533
−.761
1.00
17.16
C


ATOM
4987
CD1
LEU
A
333
−45.166
2.629
−.554
1.00
16.99
C


ATOM
4991
CD2
LEU
A
333
−42.979
1.704
.200
1.00
15.89
C


ATOM
4995
C
LEU
A
333
−45.100
−.320
−3.005
1.00
17.70
C


ATOM
4996
O
LEU
A
333
−45.321
.603
−3.795
1.00
17.86
O


ATOM
4998
N
TYR
A
334
−44.248
−1.319
−3.234
1.00
17.63
N


ATOM
4999
CA
TYR
A
334
−43.542
−1.531
−4.489
1.00
17.44
C


ATOM
5001
CB
TYR
A
334
−42.893
−2.908
−4.444
1.00
17.50
C


ATOM
5004
CG
TYR
A
334
−41.897
−3.169
−5.523
1.00
18.03
C


ATOM
5005
CD1
TYR
A
334
−40.698
−2.473
−5.569
1.00
18.83
C


ATOM
5007
CE1
TYR
A
334
−39.764
−2.725
−6.542
1.00
18.13
C


ATOM
5009
CZ
TYR
A
334
−40.016
−3.678
−7.478
1.00
18.78
C


ATOM
5010
OH
TYR
A
334
−39.096
−3.929
−8.439
1.00
21.71
O


ATOM
5012
CE2
TYR
A
334
−41.180
−4.391
−7.462
1.00
19.74
C


ATOM
5014
CD2
TYR
A
334
−42.118
−4.139
−6.472
1.00
19.59
C


ATOM
5016
C
TYR
A
334
−44.500
−1.497
−5.649
1.00
17.43
C


ATOM
5017
O
TYR
A
334
−44.264
−.803
−6.636
1.00
17.64
O


ATOM
5019
N
ASN
A
335
−45.589
−2.253
−5.504
1.00
17.30
N


ATOM
5020
CA
ASN
A
335
−46.574
−2.448
−6.553
1.00
17.23
C


ATOM
5022
CB
ASN
A
335
−47.544
−3.551
−6.166
1.00
17.32
C


ATOM
5025
CG
ASN
A
335
−46.952
−4.920
−6.332
1.00
18.16
C


ATOM
5026
OD1
ASN
A
335
−45.913
−5.090
−6.989
1.00
18.99
O


ATOM
5027
ND2
ASN
A
335
−47.616
−5.921
−5.749
1.00
18.49
N


ATOM
5030
C
ASN
A
335
−47.365
−1.218
−6.812
1.00
17.12
C


ATOM
5031
O
ASN
A
335
−47.613
−.852
−7.965
1.00
17.36
O


ATOM
5033
N
THR
A
336
−47.789
−.602
−5.722
1.00
17.20
N


ATOM
5034
CA
THR
A
336
−48.601
.593
−5.779
1.00
17.36
C


ATOM
5036
CB
THR
A
336
−48.888
1.104
−4.381
1.00
17.20
C


ATOM
5038
OG1
THR
A
336
−49.611
.103
−3.657
1.00
16.26
O


ATOM
5040
CG2
THR
A
336
−49.688
2.384
−4.452
1.00
17.18
C


ATOM
5044
C
THR
A
336
−47.893
1.691
−6.550
1.00
17.84
C


ATOM
5045
O
THR
A
336
−48.511
2.388
−7.360
1.00
18.07
O


ATOM
5047
N
ILE
A
337
−46.595
1.831
−6.298
1.00
18.14
N


ATOM
5048
CA
ILE
A
337
−45.817
2.904
−6.895
1.00
18.50
C


ATOM
5050
CB
ILE
A
337
−44.584
3.209
−6.066
1.00
18.31
C


ATOM
5052
CG1
ILE
A
337
−45.014
3.997
−4.837
1.00
18.58
C


ATOM
5055
CD1
ILE
A
337
−44.043
3.866
−3.735
1.00
20.66
C


ATOM
5059
CG2
ILE
A
337
−43.570
3.988
−6.867
1.00
16.98
C


ATOM
5063
C
ILE
A
337
−45.447
2.548
−8.314
1.00
19.29
C


ATOM
5064
O
ILE
A
337
−45.556
3.387
−9.214
1.00
19.17
O


ATOM
5066
N
ASN
A
338
−45.033
1.299
−8.513
1.00
20.16
N


ATOM
5067
CA
ASN
A
338
−44.861
.767
−9.864
1.00
20.93
C


ATOM
5069
CB
ASN
A
338
−44.409
−.695
−9.830
1.00
21.07
C


ATOM
5072
CG
ASN
A
338
−42.953
−.845
−9.439
1.00
21.61
C


ATOM
5073
OD1
ASN
A
338
−42.232
.143
−9.308
1.00
22.40
O


ATOM
5074
ND2
ASN
A
338
−42.509
−2.086
−9.260
1.00
21.92
N


ATOM
5077
C
ASN
A
338
−46.123
.914
−10.719
1.00
21.44
C


ATOM
5078
O
ASN
A
338
−46.022
1.202
−11.904
1.00
21.25
O


ATOM
5080
N
GLU
A
339
−47.303
.747
−10.128
1.00
22.21
N


ATOM
5081
CA
GLU
A
339
−48.532
1.000
−10.880
1.00
23.31
C


ATOM
5083
CB
GLU
A
339
−49.768
.464
−10.164
1.00
24.13
C


ATOM
5086
CG
GLU
A
339
−50.146
−.936
−10.660
1.00
28.69
C


ATOM
5089
CD
GLU
A
339
−50.939
−1.740
−9.638
1.00
35.06
C


ATOM
5090
OE1
GLU
A
339
−51.899
−1.136
−9.067
1.00
39.51
O


ATOM
5091
OE2
GLU
A
339
−50.596
−2.952
−9.414
1.00
36.64
O


ATOM
5092
C
GLU
A
339
−48.725
2.463
−11.269
1.00
22.71
C


ATOM
5093
O
GLU
A
339
−49.215
2.743
−12.372
1.00
22.48
O


ATOM
5095
N
ILE
A
340
−48.339
3.390
−10.390
1.00
22.19
N


ATOM
5096
CA
ILE
A
340
−48.406
4.813
−10.734
1.00
21.64
C


ATOM
5098
CB
ILE
A
340
−48.135
5.739
−9.538
1.00
21.33
C


ATOM
5100
CG1
ILE
A
340
−49.229
5.596
−8.482
1.00
21.29
C


ATOM
5103
CD1
ILE
A
340
−48.925
6.306
−7.150
1.00
20.00
C


ATOM
5107
CG2
ILE
A
340
−48.091
7.177
−9.982
1.00
20.28
C


ATOM
5111
C
ILE
A
340
−47.414
5.128
−11.861
1.00
21.78
C


ATOM
5112
O
ILE
A
340
−47.786
5.826
−12.818
1.00
22.13
O


ATOM
5114
N
ALA
A
341
−46.179
4.609
−11.771
1.00
21.34
N


ATOM
5115
CA
ALA
A
341
−45.147
4.892
−12.787
1.00
21.03
C


ATOM
5117
CB
ALA
A
341
−43.837
4.268
−12.406
1.00
20.55
C


ATOM
5121
C
ALA
A
341
−45.592
4.426
−14.183
1.00
21.32
C


ATOM
5122
O
ALA
A
341
−45.228
5.036
−15.217
1.00
21.11
O


ATOM
5124
N
TYR
A
342
−46.393
3.355
−14.196
1.00
21.45
N


ATOM
5125
CA
TYR
A
342
−47.008
2.861
−15.414
1.00
21.41
C


ATOM
5127
CB
TYR
A
342
−47.627
1.468
−15.208
1.00
21.31
C


ATOM
5130
CG
TYR
A
342
−48.336
.957
−16.450
1.00
19.60
C


ATOM
5131
CD1
TYR
A
342
−47.613
.463
−17.521
1.00
16.69
C


ATOM
5133
CE1
TYR
A
342
−48.231
.032
−18.643
1.00
15.50
C


ATOM
5135
CZ
TYR
A
342
−49.595
.085
−18.728
1.00
15.88
C


ATOM
5136
OH
TYR
A
342
−50.196
−.352
−19.877
1.00
16.46
O


ATOM
5138
CE2
TYR
A
342
−50.352
.558
−17.681
1.00
16.50
C


ATOM
5140
CD2
TYR
A
342
−49.725
.997
−16.556
1.00
18.17
C


ATOM
5142
C
TYR
A
342
−48.064
3.830
−15.899
1.00
22.08
C


ATOM
5143
O
TYR
A
342
−48.094
4.169
−17.048
1.00
22.07
O


ATOM
5145
N
ASP
A
343
−48.942
4.283
−15.032
1.00
23.41
N


ATOM
5146
CA
ASP
A
343
−49.970
5.211
−15.481
1.00
24.66
C


ATOM
5148
CB
ASP
A
343
−50.851
5.674
−14.318
1.00
25.10
C


ATOM
5151
CG
ASP
A
343
−51.720
4.552
−13.732
1.00
26.06
C


ATOM
5152
OD1
ASP
A
343
−52.107
3.613
−14.477
1.00
26.39
O


ATOM
5153
OD2
ASP
A
343
−52.032
4.642
−12.516
1.00
27.29
O


ATOM
5154
C
ASP
A
343
−49.316
6.420
−16.142
1.00
25.22
C


ATOM
5155
O
ASP
A
343
−49.755
6.874
−17.192
1.00
25.47
O


ATOM
5157
N
ASN
A
344
−48.260
6.936
−15.528
1.00
25.87
N


ATOM
5158
CA
ASN
A
344
−47.508
8.042
−16.127
1.00
26.41
C


ATOM
5160
CB
ASN
A
344
−46.498
8.605
−15.134
1.00
26.56
C


ATOM
5163
CG
ASN
A
344
−47.152
9.407
−14.073
1.00
26.95
C


ATOM
5164
OD1
ASN
A
344
−47.495
10.568
−14.296
1.00
29.13
O


ATOM
5165
ND2
ASN
A
344
−47.367
8.799
−12.916
1.00
26.36
N


ATOM
5168
C
ASN
A
344
−46.785
7.674
−17.416
1.00
26.53
C


ATOM
5169
O
ASN
A
344
−46.658
8.508
−18.304
1.00
26.74
O


ATOM
5171
N
LEU
A
345
−46.280
6.448
−17.510
1.00
26.56
N


ATOM
5172
CA
LEU
A
345
−45.634
6.019
−18.739
1.00
26.37
C


ATOM
5174
CB
LEU
A
345
−44.890
4.693
−18.550
1.00
26.32
C


ATOM
5177
CG
LEU
A
345
−43.995
4.339
−19.750
1.00
25.96
C


ATOM
5179
CD1
LEU
A
345
−42.706
5.133
−19.665
1.00
25.07
C


ATOM
5183
CD2
LEU
A
345
−43.724
2.835
−19.874
1.00
24.75
C


ATOM
5187
C
LEU
A
345
−46.679
5.908
−19.856
1.00
26.38
C


ATOM
5188
O
LEU
A
345
−46.435
6.335
−20.966
1.00
26.52
O


ATOM
5190
N
LYS
A
346
−47.839
5.340
−19.563
1.00
26.59
N


ATOM
5191
CA
LYS
A
346
−48.880
5.176
−20.572
1.00
26.89
C


ATOM
5193
CB
LYS
A
346
−50.065
4.367
−20.011
1.00
26.80
C


ATOM
5196
CG
LYS
A
346
−51.073
3.931
−21.062
1.00
26.26
C


ATOM
5199
CD
LYS
A
346
−52.210
3.080
−20.517
1.00
26.15
C


ATOM
5202
CE
LYS
A
346
−53.227
3.849
−19.689
1.00
26.40
C


ATOM
5205
NZ
LYS
A
346
−53.136
3.506
−18.223
1.00
27.67
N


ATOM
5209
C
LYS
A
346
−49.372
6.537
−21.071
1.00
27.52
C


ATOM
5210
O
LYS
A
346
−49.562
6.742
−22.272
1.00
27.57
O


ATOM
5212
N
ASP
A
347
−49.567
7.472
−20.148
1.00
28.10
N


ATOM
5213
CA
ASP
A
347
−50.309
8.689
−20.465
1.00
28.58
C


ATOM
5215
CB
ASP
A
347
−51.305
9.017
−19.329
1.00
28.85
C


ATOM
5218
CG
ASP
A
347
−52.426
7.950
−19.197
1.00
30.01
C


ATOM
5219
OD1
ASP
A
347
−52.827
7.349
−20.223
1.00
30.51
O


ATOM
5220
OD2
ASP
A
347
−52.910
7.704
−18.069
1.00
32.61
O


ATOM
5221
C
ASP
A
347
−49.407
9.871
−20.804
1.00
28.22
C


ATOM
5222
O
ASP
A
347
−49.778
10.710
−21.611
1.00
28.39
O


ATOM
5224
N
LYS
A
348
−48.228
9.930
−20.206
1.00
28.03
N


ATOM
5225
CA
LYS
A
348
−47.301
11.021
−20.467
1.00
28.01
C


ATOM
5227
CB
LYS
A
348
−46.785
11.648
−19.164
1.00
28.39
C


ATOM
5230
CG
LYS
A
348
−47.834
12.305
−18.257
1.00
30.18
C


ATOM
5233
CD
LYS
A
348
−47.143
12.898
−17.003
1.00
32.40
C


ATOM
5236
CE
LYS
A
348
−48.124
13.121
−15.874
1.00
33.59
C


ATOM
5239
NZ
LYS
A
348
−49.319
13.878
−16.341
1.00
35.48
N


ATOM
5243
C
LYS
A
348
−46.107
10.551
−21.260
1.00
27.25
C


ATOM
5244
O
LYS
A
348
−45.241
11.345
−21.566
1.00
27.60
O


ATOM
5246
N
GLY
A
349
−46.036
9.271
−21.583
1.00
26.47
N


ATOM
5247
CA
GLY
A
349
−44.863
8.742
−22.261
1.00
26.01
C


ATOM
5250
C
GLY
A
349
−43.559
9.109
−21.587
1.00
25.67
C


ATOM
5251
O
GLY
A
349
−42.613
9.472
−22.250
1.00
25.85
O


ATOM
5253
N
GLU
A
350
−43.498
9.032
−20.269
1.00
25.55
N


ATOM
5254
CA
GLU
A
350
−42.272
9.374
−19.555
1.00
25.76
C


ATOM
5256
CB
GLU
A
350
−42.332
10.814
−19.021
1.00
26.34
C


ATOM
5259
CG
GLU
A
350
−42.179
11.928
−20.106
1.00
29.04
C


ATOM
5262
CD
GLU
A
350
−40.745
12.101
−20.598
1.00
32.08
C


ATOM
5263
OE1
GLU
A
350
−39.853
12.170
−19.716
1.00
35.46
O


ATOM
5264
OE2
GLU
A
350
−40.516
12.174
−21.839
1.00
31.64
O


ATOM
5265
C
GLU
A
350
−42.084
8.414
−18.400
1.00
24.87
C


ATOM
5266
O
GLU
A
350
−43.067
8.046
−17.760
1.00
25.16
O


ATOM
5268
N
ASN
A
351
−40.833
8.009
−18.145
1.00
23.71
N


ATOM
5269
CA
ASN
A
351
−40.494
7.189
−16.980
1.00
22.88
C


ATOM
5271
CB
ASN
A
351
−39.351
6.229
−17.287
1.00
22.88
C


ATOM
5274
CG
ASN
A
351
−39.141
5.215
−16.184
1.00
22.98
C


ATOM
5275
OD1
ASN
A
351
−39.006
5.584
−15.035
1.00
22.68
O


ATOM
5276
ND2
ASN
A
351
−39.139
3.924
−16.529
1.00
24.38
N


ATOM
5279
C
ASN
A
351
−40.126
8.058
−15.786
1.00
22.40
C


ATOM
5280
O
ASN
A
351
−39.097
8.741
−15.785
1.00
22.66
O


ATOM
5282
N
ILE
A
352
−40.965
8.021
−14.760
1.00
21.55
N


ATOM
5283
CA
ILE
A
352
−40.770
8.860
−13.591
1.00
20.75
C


ATOM
5285
CB
ILE
A
352
−42.002
9.788
−13.360
1.00
20.95
C


ATOM
5287
CG1
ILE
A
352
−43.263
8.970
−13.022
1.00
20.82
C


ATOM
5290
CD1
ILE
A
352
−44.237
9.698
−12.122
1.00
20.21
C


ATOM
5294
CG2
ILE
A
352
−42.266
10.669
−14.582
1.00
19.85
C


ATOM
5298
C
ILE
A
352
−40.516
8.016
−12.339
1.00
20.37
C


ATOM
5299
O
ILE
A
352
−40.574
8.513
−11.224
1.00
20.55
O


ATOM
5301
N
LEU
A
353
−40.236
6.733
−12.519
1.00
19.98
N


ATOM
5302
CA
LEU
A
353
−40.061
5.828
−11.387
1.00
19.42
C


ATOM
5304
CB
LEU
A
353
−39.894
4.392
−11.870
1.00
19.27
C


ATOM
5307
CG
LEU
A
353
−39.989
3.318
−10.799
1.00
19.01
C


ATOM
5309
CD1
LEU
A
353
−41.164
3.574
−9.867
1.00
18.35
C


ATOM
5313
CD2
LEU
A
353
−40.085
1.938
−11.468
1.00
18.74
C


ATOM
5317
C
LEU
A
353
−38.890
6.240
−10.523
1.00
19.11
C


ATOM
5318
O
LEU
A
353
−39.022
6.319
−9.314
1.00
18.96
O


ATOM
5320
N
PRO
A
354
−37.746
6.549
−11.142
1.00
19.06
N


ATOM
5321
CA
PRO
A
354
−36.631
7.069
−10.367
1.00
19.29
C


ATOM
5323
CB
PRO
A
354
−35.749
7.717
−11.438
1.00
19.25
C


ATOM
5326
CG
PRO
A
354
−35.997
6.942
−12.638
1.00
19.08
C


ATOM
5329
CD
PRO
A
354
−37.409
6.472
−12.572
1.00
19.00
C


ATOM
5332
C
PRO
A
354
−37.024
8.122
−9.328
1.00
19.33
C


ATOM
5333
O
PRO
A
354
−36.534
8.057
−8.193
1.00
19.73
O


ATOM
5334
N
TYR
A
355
−37.891
9.063
−9.721
1.00
18.83
N


ATOM
5335
CA
TYR
A
355
−38.206
10.221
−8.898
1.00
18.79
C


ATOM
5337
CB
TYR
A
355
−38.836
11.359
−9.707
1.00
19.10
C


ATOM
5340
CG
TYR
A
355
−38.142
11.708
−11.009
1.00
20.15
C


ATOM
5341
CD1
TYR
A
355
−36.940
12.403
−11.027
1.00
20.78
C


ATOM
5343
CE1
TYR
A
355
−36.321
12.719
−12.232
1.00
22.19
C


ATOM
5345
CZ
TYR
A
355
−36.918
12.347
−13.438
1.00
22.19
C


ATOM
5346
OH
TYR
A
355
−36.341
12.660
−14.657
1.00
23.29
O


ATOM
5348
CE2
TYR
A
355
−38.113
11.677
−13.430
1.00
21.62
C


ATOM
5350
CD2
TYR
A
355
−38.720
11.371
−12.227
1.00
21.05
C


ATOM
5352
C
TYR
A
355
−39.155
9.864
−7.777
1.00
18.43
C


ATOM
5353
O
TYR
A
355
−39.081
10.460
−6.709
1.00
18.61
O


ATOM
5355
N
LEU
A
356
−40.058
8.917
−8.023
1.00
17.92
N


ATOM
5356
CA
LEU
A
356
−40.993
8.467
−6.994
1.00
17.38
C


ATOM
5358
CB
LEU
A
356
−42.136
7.658
−7.597
1.00
17.17
C


ATOM
5361
CG
LEU
A
356
−42.956
8.366
−8.682
1.00
17.56
C


ATOM
5363
CD1
LEU
A
356
−43.933
7.419
−9.371
1.00
17.47
C


ATOM
5367
CD2
LEU
A
356
−43.698
9.548
−8.112
1.00
18.08
C


ATOM
5371
C
LEU
A
356
−40.241
7.623
−5.978
1.00
17.10
C


ATOM
5372
O
LEU
A
356
−40.332
7.859
−4.783
1.00
17.62
O


ATOM
5374
N
THR
A
357
−39.464
6.656
−6.442
1.00
16.64
N


ATOM
5375
CA
THR
A
357
−38.775
5.769
−5.513
1.00
16.18
C


ATOM
5377
CB
THR
A
357
−38.104
4.554
−6.213
1.00
16.04
C


ATOM
5379
OG1
THR
A
357
−37.092
4.996
−7.123
1.00
15.93
O


ATOM
5381
CG2
THR
A
357
−39.142
3.732
−6.962
1.00
14.99
C


ATOM
5385
C
THR
A
357
−37.764
6.544
−4.686
1.00
16.16
C


ATOM
5386
O
THR
A
357
−37.599
6.278
−3.506
1.00
16.07
O


ATOM
5388
N
LYS
A
358
−37.107
7.524
−5.291
1.00
16.20
N


ATOM
5389
CA
LYS
A
358
−36.186
8.365
−4.543
1.00
16.46
C


ATOM
5391
CB
LYS
A
358
−35.518
9.386
−5.453
1.00
16.80
C


ATOM
5394
CG
LYS
A
358
−34.612
10.388
−4.741
1.00
18.30
C


ATOM
5397
CD
LYS
A
358
−33.352
9.738
−4.168
1.00
20.21
C


ATOM
5400
CE
LYS
A
358
−32.335
10.811
−3.768
1.00
21.96
C


ATOM
5403
NZ
LYS
A
358
−31.163
10.275
−3.019
1.00
22.95
N


ATOM
5407
C
LYS
A
358
−36.936
9.083
−3.440
1.00
16.26
C


ATOM
5408
O
LYS
A
358
−36.448
9.161
−2.320
1.00
16.15
O


ATOM
5410
N
ALA
A
359
−38.126
9.593
−3.763
1.00
16.11
N


ATOM
5411
CA
ALA
A
359
−38.937
10.332
−2.798
1.00
16.10
C


ATOM
5413
CB
ALA
A
359
−40.221
10.768
−3.406
1.00
15.71
C


ATOM
5417
C
ALA
A
359
−39.215
9.476
−1.588
1.00
16.52
C


ATOM
5418
O
ALA
A
359
−39.247
9.970
−.442
1.00
16.82
O


ATOM
5420
N
TRP
A
360
−39.398
8.187
−1.843
1.00
16.79
N


ATOM
5421
CA
TRP
A
360
−39.704
7.247
−.780
1.00
17.25
C


ATOM
5423
CB
TRP
A
360
−40.390
6.006
−1.352
1.00
17.41
C


ATOM
5426
CG
TRP
A
360
−41.852
6.129
−1.318
1.00
17.06
C


ATOM
5427
CD1
TRP
A
360
−42.664
6.451
−2.346
1.00
17.94
C


ATOM
5429
NE1
TRP
A
360
−43.967
6.489
−1.926
1.00
18.03
N


ATOM
5431
CE2
TRP
A
360
−44.002
6.193
−.592
1.00
17.72
C


ATOM
5432
CD2
TRP
A
360
−42.684
5.965
−.179
1.00
16.60
C


ATOM
5433
CE3
TRP
A
360
−42.441
5.654
1.155
1.00
16.65
C


ATOM
5435
CZ3
TRP
A
360
−43.508
5.573
2.022
1.00
16.91
C


ATOM
5437
CH2
TRP
A
360
−44.811
5.807
1.586
1.00
17.82
C


ATOM
5439
CZ2
TRP
A
360
−45.080
6.114
.282
1.00
18.49
C


ATOM
5441
C
TRP
A
360
−38.490
6.865
.073
1.00
17.52
C


ATOM
5442
O
TRP
A
360
−38.603
6.767
1.297
1.00
17.38
O


ATOM
5444
N
ALA
A
361
−37.344
6.651
−.568
1.00
17.82
N


ATOM
5445
CA
ALA
A
361
−36.122
6.336
.157
1.00
18.11
C


ATOM
5447
CB
ALA
A
361
−34.982
6.050
−.805
1.00
17.92
C


ATOM
5451
C
ALA
A
361
−35.781
7.507
1.063
1.00
18.52
C


ATOM
5452
O
ALA
A
361
−35.434
7.327
2.229
1.00
18.48
O


ATOM
5454
N
ASP
A
362
−35.911
8.711
.521
1.00
19.16
N


ATOM
5455
CA
ASP
A
362
−35.627
9.925
1.276
1.00
19.90
C


ATOM
5457
CB
ASP
A
362
−35.797
11.167
.387
1.00
20.39
C


ATOM
5460
CG
ASP
A
362
−34.596
11.424
−.530
1.00
21.84
C


ATOM
5461
OD1
ASP
A
362
−33.630
10.625
−.561
1.00
22.88
O


ATOM
5462
OD2
ASP
A
362
−34.630
12.453
−1.231
1.00
24.83
O


ATOM
5463
C
ASP
A
362
−36.532
10.039
2.510
1.00
19.91
C


ATOM
5464
O
ASP
A
362
−36.074
10.427
3.591
1.00
19.76
O


ATOM
5466
N
LEU
A
363
−37.813
9.707
2.346
1.00
19.95
N


ATOM
5467
CA
LEU
A
363
−38.747
9.688
3.478
1.00
19.85
C


ATOM
5469
CB
LEU
A
363
−40.175
9.415
3.006
1.00
19.70
C


ATOM
5472
CG
LEU
A
363
−41.219
9.293
4.123
1.00
18.58
C


ATOM
5474
CD1
LEU
A
363
−41.189
10.551
4.965
1.00
18.37
C


ATOM
5478
CD2
LEU
A
363
−42.597
9.073
3.551
1.00
16.43
C


ATOM
5482
C
LEU
A
363
−38.368
8.613
4.488
1.00
20.24
C


ATOM
5483
O
LEU
A
363
−38.314
8.875
5.691
1.00
20.52
O


ATOM
5485
N
CYS
A
364
−38.129
7.397
3.997
1.00
20.29
N


ATOM
5486
CA
CYS
A
364
−37.741
6.308
4.874
1.00
20.39
C


ATOM
5488
CB
CYS
A
364
−37.595
4.985
4.111
1.00
20.37
C


ATOM
5491
SG
CYS
A
364
−39.208
4.201
3.666
1.00
20.69
S


ATOM
5493
C
CYS
A
364
−36.467
6.683
5.646
1.00
20.59
C


ATOM
5494
O
CYS
A
364
−36.386
6.445
6.863
1.00
20.82
O


ATOM
5496
N
ASN
A
365
−35.495
7.314
4.980
1.00
20.35
N


ATOM
5497
CA
ASN
A
365
−34.282
7.716
5.697
1.00
20.14
C


ATOM
5499
CB
ASN
A
365
−33.188
8.203
4.754
1.00
20.18
C


ATOM
5502
CG
ASN
A
365
−32.359
7.064
4.184
1.00
20.55
C


ATOM
5503
OD1
ASN
A
365
−31.706
6.316
4.925
1.00
20.40
O


ATOM
5504
ND2
ASN
A
365
−32.365
6.938
2.854
1.00
21.25
N


ATOM
5507
C
ASN
A
365
−34.590
8.746
6.779
1.00
19.92
C


ATOM
5508
O
ASN
A
365
−33.997
8.685
7.857
1.00
19.94
O


ATOM
5510
N
ALA
A
366
−35.531
9.658
6.507
1.00
19.58
N


ATOM
5511
CA
ALA
A
366
−36.036
10.578
7.537
1.00
19.39
C


ATOM
5513
CB
ALA
A
366
−37.083
11.507
6.971
1.00
18.79
C


ATOM
5517
C
ALA
A
366
−36.597
9.784
8.730
1.00
19.75
C


ATOM
5518
O
ALA
A
366
−36.215
10.049
9.891
1.00
19.53
O


ATOM
5520
N
PHE
A
367
−37.460
8.797
8.447
1.00
19.69
N


ATOM
5521
CA
PHE
A
367
−37.985
7.925
9.502
1.00
20.11
C


ATOM
5523
CB
PHE
A
367
−38.952
6.857
8.967
1.00
20.47
C


ATOM
5526
CG
PHE
A
367
−40.293
7.370
8.494
1.00
21.35
C


ATOM
5527
CD1
PHE
A
367
−40.985
8.347
9.180
1.00
21.54
C


ATOM
5529
CE1
PHE
A
367
−42.224
8.775
8.732
1.00
21.47
C


ATOM
5531
CZ
PHE
A
367
−42.798
8.213
7.612
1.00
21.87
C


ATOM
5533
CE2
PHE
A
367
−42.135
7.230
6.924
1.00
22.60
C


ATOM
5535
CD2
PHE
A
367
−40.894
6.798
7.373
1.00
22.90
C


ATOM
5537
C
PHE
A
367
−36.871
7.179
10.252
1.00
20.12
C


ATOM
5538
O
PHE
A
367
−36.940
7.009
11.476
1.00
19.88
O


ATOM
5540
N
LEU
A
368
−35.868
6.696
9.516
1.00
20.30
N


ATOM
5541
CA
LEU
A
368
−34.775
5.931
10.133
1.00
20.19
C


ATOM
5543
CB
LEU
A
368
−33.783
5.413
9.085
1.00
20.08
C


ATOM
5546
CG
LEU
A
368
−32.743
4.363
9.514
1.00
19.30
C


ATOM
5548
CD1
LEU
A
368
−33.384
3.227
10.260
1.00
18.66
C


ATOM
5552
CD2
LEU
A
368
−31.968
3.807
8.319
1.00
18.16
C


ATOM
5556
C
LEU
A
368
−34.063
6.812
11.128
1.00
20.41
C


ATOM
5557
O
LEU
A
368
−33.842
6.407
12.257
1.00
20.01
O


ATOM
5559
N
GLN
A
369
−33.751
8.036
10.711
1.00
20.89
N


ATOM
5560
CA
GLN
A
369
−33.037
8.970
11.564
1.00
21.49
C


ATOM
5562
CB
GLN
A
369
−32.782
10.280
10.832
1.00
21.58
C


ATOM
5565
CG
GLN
A
369
−32.071
11.359
11.677
1.00
21.20
C


ATOM
5568
CD
GLN
A
369
−30.639
11.006
11.976
1.00
20.04
C


ATOM
5569
OE1
GLN
A
369
−30.282
10.650
13.108
1.00
19.10
O


ATOM
5570
NE2
GLN
A
369
−29.803
11.095
10.956
1.00
18.75
N


ATOM
5573
C
GLN
A
369
−33.763
9.265
12.870
1.00
22.21
C


ATOM
5574
O
GLN
A
369
−33.122
9.343
13.909
1.00
22.41
O


ATOM
5576
N
GLU
A
370
−35.080
9.455
12.822
1.00
23.05
N


ATOM
5577
CA
GLU
A
370
−35.856
9.718
14.046
1.00
23.71
C


ATOM
5579
CB
GLU
A
370
−37.329
10.041
13.726
1.00
24.04
C


ATOM
5582
CG
GLU
A
370
−37.484
11.293
12.862
1.00
26.84
C


ATOM
5585
CD
GLU
A
370
−38.897
11.910
12.834
1.00
30.36
C


ATOM
5586
OE1
GLU
A
370
−39.886
11.161
12.586
1.00
31.90
O


ATOM
5587
OE2
GLU
A
370
−38.992
13.164
13.014
1.00
31.62
O


ATOM
5588
C
GLU
A
370
−35.755
8.523
14.994
1.00
23.60
C


ATOM
5589
O
GLU
A
370
−35.534
8.689
16.199
1.00
23.33
O


ATOM
5591
N
ALA
A
371
−35.904
7.322
14.435
1.00
23.72
N


ATOM
5592
CA
ALA
A
371
−35.771
6.091
15.201
1.00
23.91
C


ATOM
5594
CB
ALA
A
371
−35.991
4.868
14.312
1.00
23.76
C


ATOM
5598
C
ALA
A
371
−34.392
6.051
15.840
1.00
24.20
C


ATOM
5599
O
ALA
A
371
−34.277
5.804
17.035
1.00
24.54
O


ATOM
5601
N
LYS
A
372
−33.355
6.333
15.049
1.00
24.38
N


ATOM
5602
CA
LYS
A
372
−31.979
6.273
15.530
1.00
24.39
C


ATOM
5604
CB
LYS
A
372
−30.970
6.466
14.393
1.00
24.43
C


ATOM
5607
CG
LYS
A
372
−30.623
5.164
13.645
1.00
25.20
C


ATOM
5610
CD
LYS
A
372
−29.188
5.149
13.069
1.00
26.09
C


ATOM
5613
CE
LYS
A
372
−29.114
5.437
11.557
1.00
27.01
C


ATOM
5616
NZ
LYS
A
372
−29.002
4.200
10.709
1.00
26.82
N


ATOM
5620
C
LYS
A
372
−31.717
7.268
16.645
1.00
24.59
C


ATOM
5621
O
LYS
A
372
−31.096
6.908
17.627
1.00
25.13
O


ATOM
5623
N
TRP
A
373
−32.181
8.507
16.520
1.00
24.78
N


ATOM
5624
CA
TRP
A
373
−32.006
9.473
17.610
1.00
24.90
C


ATOM
5626
CB
TRP
A
373
−32.565
10.863
17.266
1.00
24.75
C


ATOM
5629
CG
TRP
A
373
−31.701
11.677
16.338
1.00
23.59
C


ATOM
5630
CD1
TRP
A
373
−30.344
11.663
16.259
1.00
22.38
C


ATOM
5632
NE1
TRP
A
373
−29.915
12.539
15.298
1.00
21.59
N


ATOM
5634
CE2
TRP
A
373
−30.999
13.162
14.744
1.00
21.69
C


ATOM
5635
CD2
TRP
A
373
−32.147
12.644
15.376
1.00
22.41
C


ATOM
5636
CE3
TRP
A
373
−33.409
13.110
14.976
1.00
21.98
C


ATOM
5638
CZ3
TRP
A
373
−33.480
14.072
13.979
1.00
22.08
C


ATOM
5640
CH2
TRP
A
373
−32.313
14.567
13.366
1.00
22.31
C


ATOM
5642
CZ2
TRP
A
373
−31.067
14.124
13.736
1.00
21.87
C


ATOM
5644
C
TRP
A
373
−32.678
8.970
18.881
1.00
25.53
C


ATOM
5645
O
TRP
A
373
−32.101
9.072
19.972
1.00
25.99
O


ATOM
5647
N
LEU
A
374
−33.881
8.420
18.739
1.00
25.84
N


ATOM
5648
CA
LEU
A
374
−34.667
7.980
19.893
1.00
26.29
C


ATOM
5650
CB
LEU
A
374
−36.070
7.562
19.443
1.00
26.32
C


ATOM
5653
CG
LEU
A
374
−37.227
7.646
20.444
1.00
26.39
C


ATOM
5655
CD1
LEU
A
374
−38.456
8.286
19.761
1.00
26.95
C


ATOM
5659
CD2
LEU
A
374
−37.583
6.281
21.050
1.00
26.24
C


ATOM
5663
C
LEU
A
374
−33.982
6.824
20.623
1.00
26.77
C


ATOM
5664
O
LEU
A
374
−33.995
6.758
21.860
1.00
26.95
O


ATOM
5666
N
TYR
A
375
−33.383
5.919
19.854
1.00
27.23
N


ATOM
5667
CA
TYR
A
375
−32.706
4.761
20.425
1.00
27.74
C


ATOM
5669
CB
TYR
A
375
−32.195
3.814
19.328
1.00
27.78
C


ATOM
5672
CG
TYR
A
375
−31.526
2.556
19.848
1.00
28.74
C


ATOM
5673
CD1
TYR
A
375
−32.264
1.394
20.090
1.00
29.61
C


ATOM
5675
CE1
TYR
A
375
−31.652
.232
20.573
1.00
29.89
C


ATOM
5677
CZ
TYR
A
375
−30.287
.226
20.817
1.00
30.15
C


ATOM
5678
OH
TYR
A
375
−29.676
−.917
21.286
1.00
30.57
O


ATOM
5680
CE2
TYR
A
375
−29.530
1.367
20.579
1.00
30.05
C


ATOM
5682
CD2
TYR
A
375
−30.152
2.522
20.096
1.00
29.74
C


ATOM
5684
C
TYR
A
375
−31.553
5.248
21.275
1.00
27.97
C


ATOM
5685
O
TYR
A
375
−31.404
4.837
22.422
1.00
28.00
O


ATOM
5687
N
ASN
A
376
−30.763
6.158
20.719
1.00
28.32
N


ATOM
5688
CA
ASN
A
376
−29.531
6.590
21.368
1.00
28.71
C


ATOM
5690
CB
ASN
A
376
−28.569
7.161
20.329
1.00
28.60
C


ATOM
5693
CG
ASN
A
376
−28.215
6.159
19.255
1.00
28.32
C


ATOM
5694
OD1
ASN
A
376
−27.961
4.977
19.527
1.00
25.72
O


ATOM
5695
ND2
ASN
A
376
−28.195
6.631
18.015
1.00
29.29
N


ATOM
5698
C
ASN
A
376
−29.728
7.617
22.484
1.00
29.05
C


ATOM
5699
O
ASN
A
376
−28.752
8.021
23.136
1.00
29.03
O


ATOM
5701
N
LYS
A
377
−30.977
8.021
22.716
1.00
29.16
N


ATOM
5702
CA
LYS
A
377
−31.254
9.178
23.549
1.00
29.27
C


ATOM
5704
CB
LYS
A
377
−31.051
8.879
25.050
1.00
29.52
C


ATOM
5707
CG
LYS
A
377
−32.202
8.112
25.723
1.00
30.36
C


ATOM
5710
CD
LYS
A
377
−32.202
6.638
25.340
1.00
31.54
C


ATOM
5713
CE
LYS
A
377
−33.322
5.862
26.031
1.00
32.30
C


ATOM
5716
NZ
LYS
A
377
−33.559
4.509
25.411
1.00
32.13
N


ATOM
5720
C
LYS
A
377
−30.337
10.299
23.080
1.00
28.92
C


ATOM
5721
O
LYS
A
377
−29.590
10.867
23.875
1.00
28.94
O


ATOM
5723
N
SER
A
378
−30.377
10.575
21.776
1.00
28.52
N


ATOM
5724
CA
SER
A
378
−29.652
11.700
21.201
1.00
28.30
C


ATOM
5726
CB
SER
A
378
−29.623
11.620
19.678
1.00
28.33
C


ATOM
5729
OG
SER
A
378
−28.919
10.482
19.237
1.00
29.36
O


ATOM
5731
C
SER
A
378
−30.355
12.977
21.594
1.00
27.97
C


ATOM
5732
O
SER
A
378
−31.483
12.947
22.108
1.00
27.91
O


ATOM
5734
N
THR
A
379
−29.684
14.098
21.344
1.00
27.60
N


ATOM
5735
CA
THR
A
379
−30.257
15.422
21.581
1.00
27.24
C


ATOM
5737
CB
THR
A
379
−29.929
15.950
23.002
1.00
27.23
C


ATOM
5739
OG1
THR
A
379
−28.512
16.102
23.158
1.00
26.85
O


ATOM
5741
CG2
THR
A
379
−30.467
15.007
24.067
1.00
27.48
C


ATOM
5745
C
THR
A
379
−29.738
16.414
20.548
1.00
26.83
C


ATOM
5746
O
THR
A
379
−28.834
17.190
20.844
1.00
26.69
O


ATOM
5748
N
PRO
A
380
−30.305
16.390
19.331
1.00
26.56
N


ATOM
5749
CA
PRO
A
380
−29.884
17.315
18.278
1.00
26.52
C


ATOM
5751
CB
PRO
A
380
−30.380
16.648
16.992
1.00
26.46
C


ATOM
5754
CG
PRO
A
380
−31.281
15.533
17.408
1.00
26.41
C


ATOM
5757
CD
PRO
A
380
−31.395
15.508
18.887
1.00
26.53
C


ATOM
5760
C
PRO
A
380
−30.469
18.728
18.386
1.00
26.55
C


ATOM
5761
O
PRO
A
380
−31.472
18.966
19.063
1.00
26.69
O


ATOM
5762
N
THR
A
381
−29.840
19.661
17.692
1.00
26.51
N


ATOM
5763
CA
THR
A
381
−30.299
21.034
17.699
1.00
26.51
C


ATOM
5765
CB
THR
A
381
−29.261
21.955
17.033
1.00
26.99
C


ATOM
5767
OG1
THR
A
381
−28.919
21.431
15.732
1.00
27.65
O


ATOM
5769
CG2
THR
A
381
−28.003
22.082
17.930
1.00
26.41
C


ATOM
5773
C
THR
A
381
−31.635
21.167
16.970
1.00
26.06
C


ATOM
5774
O
THR
A
381
−31.972
20.347
16.112
1.00
26.03
O


ATOM
5776
N
PHE
A
382
−32.386
22.218
17.294
1.00
25.52
N


ATOM
5777
CA
PHE
A
382
−33.681
22.436
16.654
1.00
24.83
C


ATOM
5779
CB
PHE
A
382
−34.284
23.793
17.011
1.00
24.53
C


ATOM
5782
CG
PHE
A
382
−35.495
24.113
16.211
1.00
23.77
C


ATOM
5783
CD1
PHE
A
382
−36.745
23.715
16.637
1.00
24.50
C


ATOM
5785
CE1
PHE
A
382
−37.873
23.977
15.878
1.00
24.49
C


ATOM
5787
CZ
PHE
A
382
−37.744
24.630
14.673
1.00
24.41
C


ATOM
5789
CE2
PHE
A
382
−36.490
25.014
14.235
1.00
23.88
C


ATOM
5791
CD2
PHE
A
382
−35.381
24.752
14.999
1.00
23.29
C


ATOM
5793
C
PHE
A
382
−33.542
22.342
15.150
1.00
24.49
C


ATOM
5794
O
PHE
A
382
−34.361
21.731
14.485
1.00
24.32
O


ATOM
5796
N
ASP
A
383
−32.498
22.969
14.627
1.00
24.42
N


ATOM
5797
CA
ASP
A
383
−32.257
23.005
13.190
1.00
24.19
C


ATOM
5799
CB
ASP
A
383
−31.101
23.966
12.867
1.00
24.21
C


ATOM
5802
CG
ASP
A
383
−31.473
25.423
13.050
1.00
23.72
C


ATOM
5803
OD1
ASP
A
383
−32.634
25.794
12.837
1.00
25.60
O


ATOM
5804
OD2
ASP
A
383
−30.594
26.220
13.383
1.00
24.03
O


ATOM
5805
C
ASP
A
383
−31.982
21.612
12.599
1.00
24.06
C


ATOM
5806
O
ASP
A
383
−32.393
21.342
11.473
1.00
24.00
O


ATOM
5808
N
ASP
A
384
−31.298
20.739
13.336
1.00
23.78
N


ATOM
5809
CA
ASP
A
384
−31.078
19.379
12.848
1.00
24.11
C


ATOM
5811
CB
ASP
A
384
−29.981
18.651
13.632
1.00
24.54
C


ATOM
5814
CG
ASP
A
384
−28.573
19.009
13.159
1.00
26.32
C


ATOM
5815
OD1
ASP
A
384
−28.441
19.852
12.232
1.00
28.55
O


ATOM
5816
OD2
ASP
A
384
−27.599
18.451
13.728
1.00
27.18
O


ATOM
5817
C
ASP
A
384
−32.351
18.550
12.905
1.00
23.83
C


ATOM
5818
O
ASP
A
384
−32.670
17.825
11.955
1.00
24.24
O


ATOM
5820
N
TYR
A
385
−33.070
18.637
14.017
1.00
23.31
N


ATOM
5821
CA
TYR
A
385
−34.294
17.861
14.179
1.00
22.89
C


ATOM
5823
CB
TYR
A
385
−34.833
17.979
15.608
1.00
22.86
C


ATOM
5826
CG
TYR
A
385
−36.144
17.245
15.807
1.00
22.65
C


ATOM
5827
CD1
TYR
A
385
−36.163
15.868
16.030
1.00
22.36
C


ATOM
5829
CE1
TYR
A
385
−37.351
15.189
16.206
1.00
22.77
C


ATOM
5831
CZ
TYR
A
385
−38.545
15.887
16.146
1.00
23.54
C


ATOM
5832
OH
TYR
A
385
−39.733
15.212
16.309
1.00
24.38
O


ATOM
5834
CE2
TYR
A
385
−38.554
17.258
15.913
1.00
22.76
C


ATOM
5836
CD2
TYR
A
385
−37.360
17.923
15.744
1.00
22.12
C


ATOM
5838
C
TYR
A
385
−35.375
18.299
13.190
1.00
22.55
C


ATOM
5839
O
TYR
A
385
−36.050
17.467
12.584
1.00
22.85
O


ATOM
5841
N
PHE
A
386
−35.537
19.609
13.042
1.00
22.08
N


ATOM
5842
CA
PHE
A
386
−36.626
20.155
12.248
1.00
21.62
C


ATOM
5844
CB
PHE
A
386
−36.857
21.628
12.568
1.00
21.73
C


ATOM
5847
CG
PHE
A
386
−38.033
22.209
11.851
1.00
21.54
C


ATOM
5848
CD1
PHE
A
386
−39.311
21.933
12.273
1.00
21.29
C


ATOM
5850
CE1
PHE
A
386
−40.380
22.444
11.623
1.00
22.11
C


ATOM
5852
CZ
PHE
A
386
−40.193
23.240
10.517
1.00
23.28
C


ATOM
5854
CE2
PHE
A
386
−38.920
23.502
10.069
1.00
23.10
C


ATOM
5856
CD2
PHE
A
386
−37.853
22.989
10.737
1.00
22.15
C


ATOM
5858
C
PHE
A
386
−36.369
19.987
10.769
1.00
21.09
C


ATOM
5859
O
PHE
A
386
−37.278
19.700
10.006
1.00
20.91
O


ATOM
5861
N
GLY
A
387
−35.127
20.177
10.362
1.00
20.68
N


ATOM
5862
CA
GLY
A
387
−34.747
19.917
8.985
1.00
20.43
C


ATOM
5865
C
GLY
A
387
−35.151
18.521
8.544
1.00
19.95
C


ATOM
5866
O
GLY
A
387
−35.553
18.327
7.398
1.00
20.24
O


ATOM
5868
N
ASN
A
388
−35.032
17.554
9.451
1.00
19.12
N


ATOM
5869
CA
ASN
A
388
−35.451
16.182
9.202
1.00
18.73
C


ATOM
5871
CB
ASN
A
388
−34.744
15.272
10.205
1.00
18.90
C


ATOM
5874
CG
ASN
A
388
−34.863
13.795
9.871
1.00
18.35
C


ATOM
5875
OD1
ASN
A
388
−34.163
13.284
8.993
1.00
17.24
O


ATOM
5876
ND2
ASN
A
388
−35.714
13.092
10.614
1.00
17.01
N


ATOM
5879
C
ASN
A
388
−36.968
16.033
9.350
1.00
18.65
C


ATOM
5880
O
ASN
A
388
−37.624
15.370
8.551
1.00
18.82
O


ATOM
5882
N
ALA
A
389
−37.527
16.670
10.371
1.00
18.38
N


ATOM
5883
CA
ALA
A
389
−38.926
16.477
10.728
1.00
18.02
C


ATOM
5885
CB
ALA
A
389
−39.203
17.107
12.084
1.00
17.83
C


ATOM
5889
C
ALA
A
389
−39.949
16.966
9.700
1.00
17.90
C


ATOM
5890
O
ALA
A
389
−41.095
16.544
9.760
1.00
17.74
O


ATOM
5892
N
TRP
A
390
−39.585
17.860
8.783
1.00
18.11
N


ATOM
5893
CA
TRP
A
390
−40.543
18.254
7.731
1.00
18.46
C


ATOM
5895
CB
TRP
A
390
−40.459
19.737
7.329
1.00
18.59
C


ATOM
5898
CG
TRP
A
390
−39.143
20.224
6.821
1.00
19.26
C


ATOM
5899
CD1
TRP
A
390
−38.224
20.947
7.519
1.00
20.64
C


ATOM
5901
NE1
TRP
A
390
−37.138
21.224
6.729
1.00
20.62
N


ATOM
5903
CE2
TRP
A
390
−37.352
20.694
5.485
1.00
19.57
C


ATOM
5904
CD2
TRP
A
390
−38.607
20.066
5.504
1.00
19.15
C


ATOM
5905
CE3
TRP
A
390
−39.060
19.448
4.344
1.00
20.13
C


ATOM
5907
CZ3
TRP
A
390
−38.254
19.477
3.224
1.00
20.27
C


ATOM
5909
CH2
TRP
A
390
−37.017
20.110
3.239
1.00
19.38
C


ATOM
5911
CZ2
TRP
A
390
−36.549
20.724
4.356
1.00
19.49
C


ATOM
5913
C
TRP
A
390
−40.407
17.343
6.527
1.00
18.73
C


ATOM
5914
O
TRP
A
390
−41.369
17.143
5.788
1.00
18.32
O


ATOM
5916
N
LYS
A
391
−39.200
16.806
6.336
1.00
19.30
N


ATOM
5917
CA
LYS
A
391
−38.969
15.692
5.404
1.00
19.70
C


ATOM
5919
CB
LYS
A
391
−37.459
15.392
5.244
1.00
19.92
C


ATOM
5922
CG
LYS
A
391
−36.812
15.953
3.935
1.00
22.08
C


ATOM
5925
CD
LYS
A
391
−35.257
16.217
4.040
1.00
23.92
C


ATOM
5928
CE
LYS
A
391
−34.918
17.698
4.426
1.00
24.43
C


ATOM
5931
NZ
LYS
A
391
−33.699
17.901
5.307
1.00
23.23
N


ATOM
5935
C
LYS
A
391
−39.731
14.441
5.861
1.00
19.46
C


ATOM
5936
O
LYS
A
391
−40.284
13.709
5.032
1.00
20.07
O


ATOM
5938
N
SER
A
392
−39.793
14.202
7.170
1.00
18.95
N


ATOM
5939
CA
SER
A
392
−40.455
12.998
7.666
1.00
18.63
C


ATOM
5941
CB
SER
A
392
−39.850
12.508
9.000
1.00
18.75
C


ATOM
5944
OG
SER
A
392
−40.314
13.230
10.126
1.00
18.94
O


ATOM
5946
C
SER
A
392
−41.964
13.152
7.771
1.00
18.20
C


ATOM
5947
O
SER
A
392
−42.654
12.182
8.031
1.00
18.12
O


ATOM
5949
N
SER
A
393
−42.477
14.360
7.567
1.00
18.07
N


ATOM
5950
CA
SER
A
393
−43.929
14.591
7.556
1.00
18.02
C


ATOM
5952
CB
SER
A
393
−44.229
16.078
7.504
1.00
18.08
C


ATOM
5955
OG
SER
A
393
−43.995
16.558
6.192
1.00
18.01
O


ATOM
5957
C
SER
A
393
−44.594
13.971
6.340
1.00
17.87
C


ATOM
5958
O
SER
A
393
−45.778
13.661
6.372
1.00
18.03
O


ATOM
5960
N
SER
A
394
−43.823
13.841
5.264
1.00
17.69
N


ATOM
5961
CA
SER
A
394
−44.284
13.306
3.989
1.00
17.59
C


ATOM
5963
CB
SER
A
394
−45.329
12.180
4.149
1.00
17.61
C


ATOM
5966
OG
SER
A
394
−46.648
12.681
4.294
1.00
17.18
O


ATOM
5968
C
SER
A
394
−44.828
14.415
3.115
1.00
17.42
C


ATOM
5969
O
SER
A
394
−45.345
14.146
2.024
1.00
17.31
O


ATOM
5971
N
GLY
A
395
−44.711
15.654
3.592
1.00
17.23
N


ATOM
5972
CA
GLY
A
395
−45.088
16.827
2.807
1.00
17.26
C


ATOM
5975
C
GLY
A
395
−44.478
16.749
1.415
1.00
17.29
C


ATOM
5976
O
GLY
A
395
−45.203
16.653
.413
1.00
18.06
O


ATOM
5978
N
PRO
A
396
−43.145
16.754
1.331
1.00
16.72
N


ATOM
5979
CA
PRO
A
396
−42.582
16.610
.006
1.00
16.40
C


ATOM
5981
CB
PRO
A
396
−41.080
16.549
.259
1.00
16.62
C


ATOM
5984
CG
PRO
A
396
−40.903
16.749
1.775
1.00
17.11
C


ATOM
5987
CD
PRO
A
396
−42.157
17.252
2.296
1.00
16.87
C


ATOM
5990
C
PRO
A
396
−43.053
15.374
−.748
1.00
15.89
C


ATOM
5991
O
PRO
A
396
−43.501
15.498
−1.894
1.00
15.90
O


ATOM
5992
N
LEU
A
397
−42.973
14.197
−.135
1.00
15.27
N


ATOM
5993
CA
LEU
A
397
−43.287
12.976
−.886
1.00
14.57
C


ATOM
5995
CB
LEU
A
397
−43.332
11.733
−.008
1.00
14.36
C


ATOM
5998
CG
LEU
A
397
−43.541
10.431
−.781
1.00
14.02
C


ATOM
6000
CD1
LEU
A
397
−42.690
9.348
−.206
1.00
15.04
C


ATOM
6004
CD2
LEU
A
397
−44.985
9.976
−.805
1.00
13.75
C


ATOM
6008
C
LEU
A
397
−44.618
13.182
−1.542
1.00
14.39
C


ATOM
6009
O
LEU
A
397
−44.736
12.999
−2.745
1.00
14.57
O


ATOM
6011
N
GLN
A
398
−45.604
13.607
−.751
1.00
14.08
N


ATOM
6012
CA
GLN
A
398
−46.962
13.828
−1.245
1.00
13.91
C


ATOM
6014
CB
GLN
A
398
−47.860
14.363
−.136
1.00
13.99
C


ATOM
6017
CG
GLN
A
398
−48.274
13.321
.909
1.00
14.01
C


ATOM
6020
CD
GLN
A
398
−49.189
13.902
1.983
1.00
13.41
C


ATOM
6021
OE1
GLN
A
398
−49.941
14.847
1.740
1.00
14.65
O


ATOM
6022
NE2
GLN
A
398
−49.122
13.344
3.168
1.00
12.17
N


ATOM
6025
C
GLN
A
398
−47.015
14.800
−2.403
1.00
13.84
C


ATOM
6026
O
GLN
A
398
−47.677
14.547
−3.396
1.00
13.46
O


ATOM
6028
N
LEU
A
399
−46.319
15.922
−2.272
1.00
14.11
N


ATOM
6029
CA
LEU
A
399
−46.359
16.942
−3.315
1.00
14.37
C


ATOM
6031
CB
LEU
A
399
−45.900
18.282
−2.756
1.00
14.26
C


ATOM
6034
CG
LEU
A
399
−46.882
18.830
−1.704
1.00
14.44
C


ATOM
6036
CD1
LEU
A
399
−46.250
19.960
−.919
1.00
16.43
C


ATOM
6040
CD2
LEU
A
399
−48.191
19.304
−2.317
1.00
12.20
C


ATOM
6044
C
LEU
A
399
−45.582
16.525
−4.578
1.00
14.68
C


ATOM
6045
O
LEU
A
399
−46.043
16.784
−5.687
1.00
14.70
O


ATOM
6047
N
ILE
A
400
−44.443
15.844
−4.419
1.00
14.92
N


ATOM
6048
CA
ILE
A
400
−43.748
15.221
−5.564
1.00
15.08
C


ATOM
6050
CB
ILE
A
400
−42.549
14.355
−5.129
1.00
15.35
C


ATOM
6052
CG1
ILE
A
400
−41.406
15.254
−4.611
1.00
16.83
C


ATOM
6055
CD1
ILE
A
400
−40.234
14.490
−3.958
1.00
17.18
C


ATOM
6059
CG2
ILE
A
400
−42.060
13.486
−6.292
1.00
14.03
C


ATOM
6063
C
ILE
A
400
−44.682
14.329
−6.358
1.00
15.08
C


ATOM
6064
O
ILE
A
400
−44.672
14.362
−7.574
1.00
15.18
O


ATOM
6066
N
PHE
A
401
−45.474
13.524
−5.650
1.00
15.16
N


ATOM
6067
CA
PHE
A
401
−46.501
12.674
−6.258
1.00
14.90
C


ATOM
6069
CB
PHE
A
401
−47.052
11.663
−5.240
1.00
14.51
C


ATOM
6072
CG
PHE
A
401
−46.294
10.378
−5.201
1.00
12.92
C


ATOM
6073
CD1
PHE
A
401
−46.727
9.282
−5.931
1.00
11.98
C


ATOM
6075
CE1
PHE
A
401
−46.032
8.093
−5.917
1.00
11.20
C


ATOM
6077
CZ
PHE
A
401
−44.881
7.985
−5.165
1.00
12.03
C


ATOM
6079
CE2
PHE
A
401
−44.431
9.078
−4.428
1.00
11.98
C


ATOM
6081
CD2
PHE
A
401
−45.143
10.263
−4.453
1.00
12.09
C


ATOM
6083
C
PHE
A
401
−47.641
13.509
−6.806
1.00
15.39
C


ATOM
6084
O
PHE
A
401
−48.183
13.215
−7.858
1.00
15.51
O


ATOM
6086
N
ALA
A
402
−48.022
14.545
−6.080
1.00
16.15
N


ATOM
6087
CA
ALA
A
402
−49.110
15.393
−6.525
1.00
16.90
C


ATOM
6089
CB
ALA
A
402
−49.391
16.473
−5.505
1.00
16.99
C


ATOM
6093
C
ALA
A
402
−48.722
16.003
−7.856
1.00
17.50
C


ATOM
6094
O
ALA
A
402
−49.549
16.100
−8.770
1.00
17.48
O


ATOM
6096
N
TYR
A
403
−47.444
16.367
−7.963
1.00
18.28
N


ATOM
6097
CA
TYR
A
403
−46.916
17.046
−9.142
1.00
18.94
C


ATOM
6099
CB
TYR
A
403
−45.412
17.252
−9.043
1.00
19.03
C


ATOM
6102
CG
TYR
A
403
−44.823
17.801
−10.314
1.00
19.79
C


ATOM
6103
CD1
TYR
A
403
−44.973
19.138
−10.652
1.00
20.80
C


ATOM
6105
CE1
TYR
A
403
−44.436
19.643
−11.827
1.00
20.73
C


ATOM
6107
CZ
TYR
A
403
−43.759
18.804
−12.674
1.00
21.16
C


ATOM
6108
OH
TYR
A
403
−43.231
19.283
−13.836
1.00
22.98
O


ATOM
6110
CE2
TYR
A
403
−43.608
17.476
−12.370
1.00
21.23
C


ATOM
6112
CD2
TYR
A
403
−44.137
16.980
−11.195
1.00
20.93
C


ATOM
6114
C
TYR
A
403
−47.198
16.293
−10.413
1.00
19.39
C


ATOM
6115
O
TYR
A
403
−47.567
16.904
−11.422
1.00
19.57
O


ATOM
6117
N
PHE
A
404
−47.023
14.976
−10.376
1.00
19.74
N


ATOM
6118
CA
PHE
A
404
−47.239
14.177
−11.573
1.00
20.35
C


ATOM
6120
CB
PHE
A
404
−46.533
12.841
−11.466
1.00
19.96
C


ATOM
6123
CG
PHE
A
404
−45.048
12.971
−11.387
1.00
18.81
C


ATOM
6124
CD1
PHE
A
404
−44.292
13.115
−12.528
1.00
17.42
C


ATOM
6126
CE1
PHE
A
404
−42.935
13.239
−12.457
1.00
17.24
C


ATOM
6128
CZ
PHE
A
404
−42.312
13.237
−11.237
1.00
17.40
C


ATOM
6130
CE2
PHE
A
404
−43.056
13.106
−10.093
1.00
17.72
C


ATOM
6132
CD2
PHE
A
404
−44.413
12.975
−10.170
1.00
17.93
C


ATOM
6134
C
PHE
A
404
−48.713
13.994
−11.894
1.00
21.59
C


ATOM
6135
O
PHE
A
404
−49.072
13.717
−13.046
1.00
21.71
O


ATOM
6137
N
ALA
A
405
−49.572
14.169
−10.896
1.00
22.87
N


ATOM
6138
CA
ALA
A
405
−50.990
13.939
−11.099
1.00
24.06
C


ATOM
6140
CB
ALA
A
405
−51.604
13.408
−9.833
1.00
24.15
C


ATOM
6144
C
ALA
A
405
−51.724
15.192
−11.556
1.00
25.21
C


ATOM
6145
O
ALA
A
405
−52.876
15.114
−11.939
1.00
25.51
O


ATOM
6147
N
VAL
A
406
−51.056
16.336
−11.530
1.00
26.52
N


ATOM
6148
CA
VAL
A
406
−51.713
17.617
−11.759
1.00
27.68
C


ATOM
6150
CB
VAL
A
406
−51.694
18.406
−10.434
1.00
27.60
C


ATOM
6152
CG1
VAL
A
406
−51.654
19.913
−10.663
1.00
28.07
C


ATOM
6156
CG2
VAL
A
406
−52.883
18.009
−9.596
1.00
27.41
C


ATOM
6160
C
VAL
A
406
−51.097
18.429
−12.925
1.00
29.10
C


ATOM
6161
O
VAL
A
406
−51.810
19.104
−13.678
1.00
28.53
O


ATOM
6163
N
VAL
A
407
−49.772
18.356
−13.059
1.00
30.90
N


ATOM
6164
CA
VAL
A
407
−49.052
19.003
−14.151
1.00
32.15
C


ATOM
6166
CB
VAL
A
407
−47.574
19.228
−13.777
1.00
32.25
C


ATOM
6168
CG1
VAL
A
407
−46.770
19.780
−14.964
1.00
32.22
C


ATOM
6172
CG2
VAL
A
407
−47.490
20.154
−12.583
1.00
32.25
C


ATOM
6176
C
VAL
A
407
−49.134
18.160
−15.421
1.00
33.36
C


ATOM
6177
O
VAL
A
407
−48.688
17.009
−15.454
1.00
33.40
O


ATOM
6179
N
GLN
A
408
−49.693
18.767
−16.463
1.00
34.93
N


ATOM
6180
CA
GLN
A
408
−49.930
18.102
−17.749
1.00
36.16
C


ATOM
6182
CB
GLN
A
408
−50.779
19.016
−18.638
1.00
36.63
C


ATOM
6185
CG
GLN
A
408
−51.625
18.270
−19.672
1.00
38.95
C


ATOM
6188
CD
GLN
A
408
−52.991
18.930
−19.887
1.00
41.80
C


ATOM
6189
OE1
GLN
A
408
−53.739
19.150
−18.921
1.00
43.40
O


ATOM
6190
NE2
GLN
A
408
−53.323
19.244
−21.151
1.00
41.68
N


ATOM
6193
C
GLN
A
408
−48.630
17.725
−18.470
1.00
36.22
C


ATOM
6194
O
GLN
A
408
−48.456
16.588
−18.920
1.00
35.86
O


ATOM
6196
N
ASN
A
409
−47.726
18.694
−18.578
1.00
36.64
N


ATOM
6197
CA
ASN
A
409
−46.400
18.441
−19.136
1.00
36.85
C


ATOM
6199
CB
ASN
A
409
−46.134
19.306
−20.373
1.00
36.73
C


ATOM
6202
CG
ASN
A
409
−46.808
18.752
−21.604
1.00
36.19
C


ATOM
6203
OD1
ASN
A
409
−46.178
18.072
−22.420
1.00
35.00
O


ATOM
6204
ND2
ASN
A
409
−48.110
18.994
−21.720
1.00
34.99
N


ATOM
6207
C
ASN
A
409
−45.312
18.613
−18.095
1.00
36.96
C


ATOM
6208
O
ASN
A
409
−45.032
19.720
−17.618
1.00
36.81
O


ATOM
6210
N
ILE
A
410
−44.713
17.488
−17.734
1.00
37.10
N


ATOM
6211
CA
ILE
A
410
−43.625
17.508
−16.792
1.00
37.27
C


ATOM
6213
CB
ILE
A
410
−43.265
16.092
−16.295
1.00
37.38
C


ATOM
6215
CG1
ILE
A
410
−42.745
15.209
−17.426
1.00
37.84
C


ATOM
6218
CD1
ILE
A
410
−42.416
13.824
−16.985
1.00
38.96
C


ATOM
6222
CG2
ILE
A
410
−44.491
15.437
−15.676
1.00
37.67
C


ATOM
6226
C
ILE
A
410
−42.467
18.179
−17.492
1.00
37.12
C


ATOM
6227
O
ILE
A
410
−42.150
17.839
−18.617
1.00
36.87
O


ATOM
6229
N
LYS
A
411
−41.896
19.187
−16.851
1.00
37.38
N


ATOM
6230
CA
LYS
A
411
−40.680
19.813
−17.332
1.00
37.73
C


ATOM
6232
CB
LYS
A
411
−40.756
21.332
−17.171
1.00
38.15
C


ATOM
6235
CG
LYS
A
411
−41.979
21.962
−17.837
1.00
39.89
C


ATOM
6238
CD
LYS
A
411
−41.797
23.463
−18.080
1.00
42.48
C


ATOM
6241
CE
LYS
A
411
−43.029
24.069
−18.795
1.00
44.22
C


ATOM
6244
NZ
LYS
A
411
−42.977
25.576
−18.904
1.00
45.31
N


ATOM
6248
C
LYS
A
411
−39.562
19.244
−16.489
1.00
37.38
C


ATOM
6249
O
LYS
A
411
−39.721
19.112
−15.281
1.00
37.28
O


ATOM
6251
N
LYS
A
412
−38.445
18.886
−17.122
1.00
37.24
N


ATOM
6252
CA
LYS
A
412
−37.333
18.243
−16.413
1.00
36.95
C


ATOM
6254
CB
LYS
A
412
−36.286
17.701
−17.384
1.00
37.14
C


ATOM
6257
CG
LYS
A
412
−35.233
16.818
−16.720
1.00
37.89
C


ATOM
6260
CD
LYS
A
412
−34.334
16.125
−17.757
1.00
39.54
C


ATOM
6263
CE
LYS
A
412
−33.263
17.068
−18.348
1.00
40.08
C


ATOM
6266
NZ
LYS
A
412
−32.161
17.399
−17.376
1.00
40.16
N


ATOM
6270
C
LYS
A
412
−36.664
19.177
−15.419
1.00
36.42
C


ATOM
6271
O
LYS
A
412
−36.246
18.728
−14.357
1.00
36.56
O


ATOM
6273
N
GLU
A
413
−36.570
20.466
−15.744
1.00
35.77
N


ATOM
6274
CA
GLU
A
413
−35.948
21.423
−14.820
1.00
35.38
C


ATOM
6276
CB
GLU
A
413
−35.688
22.792
−15.489
1.00
35.73
C


ATOM
6279
CG
GLU
A
413
−36.510
24.013
−14.973
1.00
37.10
C


ATOM
6282
CD
GLU
A
413
−35.621
25.235
−14.633
1.00
38.51
C


ATOM
6283
OE1
GLU
A
413
−34.778
25.125
−13.714
1.00
39.24
O


ATOM
6284
OE2
GLU
A
413
−35.768
26.306
−15.266
1.00
39.04
O


ATOM
6285
C
GLU
A
413
−36.760
21.551
−13.522
1.00
34.43
C


ATOM
6286
O
GLU
A
413
−36.196
21.801
−12.460
1.00
34.34
O


ATOM
6288
N
GLU
A
414
−38.074
21.360
−13.616
1.00
33.45
N


ATOM
6289
CA
GLU
A
414
−38.956
21.407
−12.452
1.00
32.80
C


ATOM
6291
CB
GLU
A
414
−40.435
21.425
−12.864
1.00
32.83
C


ATOM
6294
CG
GLU
A
414
−40.923
22.736
−13.478
1.00
33.15
C


ATOM
6297
CD
GLU
A
414
−42.360
22.668
−14.003
1.00
33.82
C


ATOM
6298
OE1
GLU
A
414
−42.876
21.560
−14.231
1.00
35.31
O


ATOM
6299
OE2
GLU
A
414
−42.985
23.727
−14.204
1.00
33.98
O


ATOM
6300
C
GLU
A
414
−38.715
20.222
−11.536
1.00
32.18
C


ATOM
6301
O
GLU
A
414
−38.407
20.409
−10.372
1.00
32.25
O


ATOM
6303
N
ILE
A
415
−38.863
19.002
−12.044
1.00
31.63
N


ATOM
6304
CA
ILE
A
415
−38.725
17.819
−11.181
1.00
31.28
C


ATOM
6306
CB
ILE
A
415
−39.131
16.472
−11.852
1.00
31.14
C


ATOM
6308
CG1
ILE
A
415
−38.349
16.204
−13.133
1.00
31.13
C


ATOM
6311
CD1
ILE
A
415
−38.786
14.926
−13.836
1.00
30.72
C


ATOM
6315
CG2
ILE
A
415
−40.611
16.454
−12.160
1.00
31.12
C


ATOM
6319
C
ILE
A
415
−37.316
17.705
−10.636
1.00
31.08
C


ATOM
6320
O
ILE
A
415
−37.105
17.188
−9.539
1.00
31.22
O


ATOM
6322
N
GLU
A
416
−36.345
18.208
−11.381
1.00
30.67
N


ATOM
6323
CA
GLU
A
416
−34.998
18.270
−10.850
1.00
30.55
C


ATOM
6325
CB
GLU
A
416
−34.011
18.654
−11.955
1.00
30.91
C


ATOM
6328
CG
GLU
A
416
−32.654
17.967
−11.845
1.00
32.55
C


ATOM
6331
CD
GLU
A
416
−31.802
18.130
−13.109
1.00
34.91
C


ATOM
6332
OE1
GLU
A
416
−32.337
18.563
−14.161
1.00
35.53
O


ATOM
6333
OE2
GLU
A
416
−30.590
17.816
−13.052
1.00
36.45
O


ATOM
6334
C
GLU
A
416
−34.962
19.249
−9.650
1.00
29.74
C


ATOM
6335
O
GLU
A
416
−34.143
19.097
−8.738
1.00
29.73
O


ATOM
6337
N
ASN
A
417
−35.864
20.234
−9.652
1.00
28.69
N


ATOM
6338
CA
ASN
A
417
−36.060
21.134
−8.503
1.00
27.92
C


ATOM
6340
CB
ASN
A
417
−36.632
22.477
−8.963
1.00
27.75
C


ATOM
6343
CG
ASN
A
417
−35.572
23.532
−9.095
1.00
26.84
C


ATOM
6344
OD1
ASN
A
417
−35.160
24.132
−8.105
1.00
24.88
O


ATOM
6345
ND2
ASN
A
417
−35.117
23.765
−10.318
1.00
26.28
N


ATOM
6348
C
ASN
A
417
−36.917
20.580
−7.356
1.00
27.41
C


ATOM
6349
O
ASN
A
417
−36.650
20.838
−6.187
1.00
27.15
O


ATOM
6351
N
LEU
A
418
−37.955
19.834
−7.675
1.00
27.09
N


ATOM
6352
CA
LEU
A
418
−38.694
19.156
−6.628
1.00
27.02
C


ATOM
6354
CB
LEU
A
418
−39.921
18.423
−7.200
1.00
26.95
C


ATOM
6357
CG
LEU
A
418
−41.030
19.284
−7.826
1.00
25.97
C


ATOM
6359
CD1
LEU
A
418
−42.127
18.429
−8.447
1.00
24.88
C


ATOM
6363
CD2
LEU
A
418
−41.623
20.226
−6.803
1.00
24.50
C


ATOM
6367
C
LEU
A
418
−37.763
18.196
−5.860
1.00
27.26
C


ATOM
6368
O
LEU
A
418
−37.834
18.123
−4.644
1.00
27.07
O


ATOM
6370
N
GLN
A
419
−36.873
17.494
−6.561
1.00
27.67
N


ATOM
6371
CA
GLN
A
419
−35.924
16.575
−5.909
1.00
28.28
C


ATOM
6373
CB
GLN
A
419
−35.155
15.758
−6.945
1.00
28.36
C


ATOM
6376
CG
GLN
A
419
−35.747
14.375
−7.146
1.00
29.43
C


ATOM
6379
CD
GLN
A
419
−35.052
13.573
−8.215
1.00
29.76
C


ATOM
6380
OE1
GLN
A
419
−34.355
14.112
−9.066
1.00
29.93
O


ATOM
6381
NE2
GLN
A
419
−35.252
12.270
−8.184
1.00
31.33
N


ATOM
6384
C
GLN
A
419
−34.922
17.219
−4.947
1.00
28.73
C


ATOM
6385
O
GLN
A
419
−34.540
16.608
−3.952
1.00
28.90
O


ATOM
6387
N
LYS
A
420
−34.490
18.440
−5.240
1.00
29.27
N


ATOM
6388
CA
LYS
A
420
−33.608
19.166
−4.335
1.00
29.81
C


ATOM
6390
CB
LYS
A
420
−32.758
20.163
−5.129
1.00
30.24
C


ATOM
6393
CG
LYS
A
420
−31.592
19.513
−5.867
1.00
31.75
C


ATOM
6396
CD
LYS
A
420
−31.259
20.217
−7.183
1.00
34.14
C


ATOM
6399
CE
LYS
A
420
−30.140
19.463
−7.953
1.00
36.21
C


ATOM
6402
NZ
LYS
A
420
−30.073
19.759
−9.439
1.00
36.76
N


ATOM
6406
C
LYS
A
420
−34.375
19.872
−3.204
1.00
29.98
C


ATOM
6407
O
LYS
A
420
−33.759
20.547
−2.384
1.00
30.44
O


ATOM
6409
N
TYR
A
421
−35.706
19.694
−3.162
1.00
30.07
N


ATOM
6410
CA
TYR
A
421
−36.646
20.309
−2.171
1.00
29.73
C


ATOM
6412
CB
TYR
A
421
−36.298
19.949
−.712
1.00
29.59
C


ATOM
6415
CG
TYR
A
421
−36.386
18.468
−.470
1.00
30.57
C


ATOM
6416
CD1
TYR
A
421
−37.582
17.785
−.643
1.00
30.87
C


ATOM
6418
CE1
TYR
A
421
−37.665
16.414
−.448
1.00
31.28
C


ATOM
6420
CZ
TYR
A
421
−36.549
15.705
−.068
1.00
31.90
C


ATOM
6421
OH
TYR
A
421
−36.620
14.347
.124
1.00
32.43
O


ATOM
6423
CE2
TYR
A
421
−35.355
16.354
.119
1.00
32.68
C


ATOM
6425
CD2
TYR
A
421
−35.274
17.736
−.095
1.00
32.42
C


ATOM
6427
C
TYR
A
421
−36.850
21.816
−2.347
1.00
29.24
C


ATOM
6428
O
TYR
A
421
−36.709
22.590
−1.401
1.00
29.26
O


ATOM
6430
N
HIS
A
422
−37.219
22.214
−3.563
1.00
28.65
N


ATOM
6431
CA
HIS
A
422
−37.540
23.604
−3.859
1.00
28.26
C


ATOM
6433
CB
HIS
A
422
−38.150
23.715
−5.256
1.00
28.33
C


ATOM
6436
CG
HIS
A
422
−38.299
25.124
−5.748
1.00
28.44
C


ATOM
6437
ND1
HIS
A
422
−37.225
25.904
−6.106
1.00
28.97
N


ATOM
6439
CE1
HIS
A
422
−37.660
27.082
−6.520
1.00
29.40
C


ATOM
6441
NE2
HIS
A
422
−38.977
27.090
−6.443
1.00
28.14
N


ATOM
6443
CD2
HIS
A
422
−39.399
25.879
−5.965
1.00
27.76
C


ATOM
6445
C
HIS
A
422
−38.511
24.147
−2.816
1.00
27.74
C


ATOM
6446
O
HIS
A
422
−39.357
23.408
−2.310
1.00
27.53
O


ATOM
6448
N
ASP
A
423
−38.384
25.437
−2.505
1.00
27.12
N


ATOM
6449
CA
ASP
A
423
−39.186
26.072
−1.454
1.00
26.63
C


ATOM
6451
CB
ASP
A
423
−38.877
27.575
−1.349
1.00
27.05
C


ATOM
6454
CG
ASP
A
423
−37.456
27.875
−.851
1.00
28.35
C


ATOM
6455
OD1
ASP
A
423
−36.951
27.121
.018
1.00
30.99
O


ATOM
6456
OD2
ASP
A
423
−36.860
28.884
−1.322
1.00
27.89
O


ATOM
6457
C
ASP
A
423
−40.689
25.883
−1.698
1.00
25.71
C


ATOM
6458
O
ASP
A
423
−41.487
25.831
−.749
1.00
26.26
O


ATOM
6460
N
ILE
A
424
−41.075
25.781
−2.966
1.00
24.01
N


ATOM
6461
CA
ILE
A
424
−42.479
25.596
−3.327
1.00
22.72
C


ATOM
6463
CB
ILE
A
424
−42.639
25.391
−4.843
1.00
22.40
C


ATOM
6465
CG1
ILE
A
424
−44.029
25.668
−5.318
1.00
21.78
C


ATOM
6468
CD1
ILE
A
424
−44.086
25.499
−6.793
1.00
22.22
C


ATOM
6472
CG2
ILE
A
424
−42.340
23.985
−5.255
1.00
22.87
C


ATOM
6476
C
ILE
A
424
−43.103
24.442
−2.562
1.00
21.91
C


ATOM
6477
O
ILE
A
424
−44.238
24.574
−2.115
1.00
21.73
O


ATOM
6479
N
ILE
A
425
−42.365
23.334
−2.399
1.00
21.23
N


ATOM
6480
CA
ILE
A
425
−42.853
22.173
−1.634
1.00
20.73
C


ATOM
6482
CB
ILE
A
425
−42.622
20.820
−2.330
1.00
20.10
C


ATOM
6484
CG1
ILE
A
425
−41.158
20.409
−2.290
1.00
18.72
C


ATOM
6487
CD1
ILE
A
425
−40.923
19.075
−2.948
1.00
18.27
C


ATOM
6491
CG2
ILE
A
425
−43.146
20.840
−3.741
1.00
19.57
C


ATOM
6495
C
ILE
A
425
−42.252
22.060
−.242
1.00
21.21
C


ATOM
6496
O
ILE
A
425
−42.810
21.370
.613
1.00
21.30
O


ATOM
6498
N
SER
A
426
−41.129
22.721
−.002
1.00
21.56
N


ATOM
6499
CA
SER
A
426
−40.492
22.620
1.299
1.00
22.23
C


ATOM
6501
CB
SER
A
426
−39.043
23.082
1.234
1.00
22.36
C


ATOM
6504
OG
SER
A
426
−38.977
24.501
1.342
1.00
24.09
O


ATOM
6506
C
SER
A
426
−41.242
23.460
2.334
1.00
22.39
C


ATOM
6507
O
SER
A
426
−41.390
23.051
3.491
1.00
22.95
O


ATOM
6509
N
ARG
A
427
−41.701
24.643
1.937
1.00
22.08
N


ATOM
6510
CA
ARG
A
427
−42.332
25.541
2.905
1.00
21.87
C


ATOM
6512
CB
ARG
A
427
−42.466
26.955
2.345
1.00
21.99
C


ATOM
6515
CG
ARG
A
427
−41.170
27.696
2.493
1.00
23.36
C


ATOM
6518
CD
ARG
A
427
−40.954
28.727
1.433
1.00
26.07
C


ATOM
6521
NE
ARG
A
427
−39.680
29.407
1.667
1.00
28.18
N


ATOM
6523
CZ
ARG
A
427
−39.127
30.298
.844
1.00
29.21
C


ATOM
6524
NH1
ARG
A
427
−39.723
30.633
−.298
1.00
28.60
N


ATOM
6527
NH2
ARG
A
427
−37.962
30.854
1.173
1.00
30.48
N


ATOM
6530
C
ARG
A
427
−43.651
25.003
3.434
1.00
21.21
C


ATOM
6531
O
ARG
A
427
−43.817
24.891
4.645
1.00
21.11
O


ATOM
6533
N
PRO
A
428
−44.573
24.622
2.541
1.00
20.52
N


ATOM
6534
CA
PRO
A
428
−45.789
23.999
3.040
1.00
20.27
C


ATOM
6536
CB
PRO
A
428
−46.410
23.369
1.791
1.00
20.44
C


ATOM
6539
CG
PRO
A
428
−45.864
24.119
.666
1.00
20.63
C


ATOM
6542
CD
PRO
A
428
−44.521
24.644
1.074
1.00
20.54
C


ATOM
6545
C
PRO
A
428
−45.450
22.917
4.050
1.00
19.75
C


ATOM
6546
O
PRO
A
428
−46.089
22.834
5.095
1.00
19.77
O


ATOM
6547
N
SER
A
429
−44.424
22.123
3.747
1.00
18.97
N


ATOM
6548
CA
SER
A
429
−44.008
21.045
4.636
1.00
18.45
C


ATOM
6550
CB
SER
A
429
−42.954
20.180
3.972
1.00
18.35
C


ATOM
6553
OG
SER
A
429
−43.452
19.716
2.733
1.00
19.12
O


ATOM
6555
C
SER
A
429
−43.519
21.525
5.985
1.00
17.97
C


ATOM
6556
O
SER
A
429
−43.733
20.846
6.968
1.00
17.88
O


ATOM
6558
N
HIS
A
430
−42.879
22.689
6.053
1.00
17.73
N


ATOM
6559
CA
HIS
A
430
−42.593
23.289
7.359
1.00
17.71
C


ATOM
6561
CB
HIS
A
430
−41.937
24.668
7.241
1.00
17.97
C


ATOM
6564
CG
HIS
A
430
−40.558
24.663
6.651
1.00
18.87
C


ATOM
6565
ND1
HIS
A
430
−39.940
23.524
6.186
1.00
19.85
N


ATOM
6567
CE1
HIS
A
430
−38.746
23.836
5.709
1.00
19.43
C


ATOM
6569
NE2
HIS
A
430
−38.573
25.137
5.838
1.00
19.06
N


ATOM
6571
CD2
HIS
A
430
−39.693
25.681
6.418
1.00
19.32
C


ATOM
6573
C
HIS
A
430
−43.914
23.444
8.131
1.00
17.31
C


ATOM
6574
O
HIS
A
430
−44.023
23.013
9.287
1.00
17.06
O


ATOM
6576
N
ILE
A
431
−44.913
24.050
7.475
1.00
16.74
N


ATOM
6577
CA
ILE
A
431
−46.218
24.304
8.091
1.00
16.15
C


ATOM
6579
CB
ILE
A
431
−47.174
25.057
7.174
1.00
16.18
C


ATOM
6581
CG1
ILE
A
431
−46.613
26.428
6.801
1.00
17.05
C


ATOM
6584
CD1
ILE
A
431
−46.441
27.352
7.994
1.00
18.34
C


ATOM
6588
CG2
ILE
A
431
−48.496
25.263
7.860
1.00
15.28
C


ATOM
6592
C
ILE
A
431
−46.899
23.021
8.476
1.00
15.75
C


ATOM
6593
O
ILE
A
431
−47.624
22.980
9.445
1.00
15.95
O


ATOM
6595
N
PHE
A
432
−46.663
21.969
7.714
1.00
15.59
N


ATOM
6596
CA
PHE
A
432
−47.192
20.652
8.041
1.00
15.52
C


ATOM
6598
CB
PHE
A
432
−46.837
19.683
6.913
1.00
15.23
C


ATOM
6601
CG
PHE
A
432
−47.451
18.318
7.031
1.00
15.98
C


ATOM
6602
CD1
PHE
A
432
−48.324
17.972
8.052
1.00
16.55
C


ATOM
6604
CE1
PHE
A
432
−48.867
16.700
8.102
1.00
16.04
C


ATOM
6606
CZ
PHE
A
432
−48.559
15.774
7.130
1.00
15.29
C


ATOM
6608
CE2
PHE
A
432
−47.718
16.107
6.114
1.00
15.37
C


ATOM
6610
CD2
PHE
A
432
−47.172
17.364
6.061
1.00
16.74
C


ATOM
6612
C
PHE
A
432
−46.640
20.191
9.392
1.00
15.54
C


ATOM
6613
O
PHE
A
432
−47.383
20.006
10.343
1.00
15.37
O


ATOM
6615
N
ARG
A
433
−45.328
20.041
9.483
1.00
15.98
N


ATOM
6616
CA
ARG
A
433
−44.695
19.542
10.709
1.00
16.20
C


ATOM
6618
CB
ARG
A
433
−43.176
19.476
10.526
1.00
15.85
C


ATOM
6621
CG
ARG
A
433
−42.411
19.183
11.804
1.00
16.11
C


ATOM
6624
CD
ARG
A
433
−42.848
17.890
12.489
1.00
15.70
C


ATOM
6627
NE
ARG
A
433
−42.811
16.747
11.588
1.00
15.64
N


ATOM
6629
CZ
ARG
A
433
−43.377
15.571
11.838
1.00
16.27
C


ATOM
6630
NH1
ARG
A
433
−44.029
15.359
12.965
1.00
16.82
N


ATOM
6633
NH2
ARG
A
433
−43.302
14.598
10.948
1.00
16.96
N


ATOM
6636
C
ARG
A
433
−45.029
20.411
11.935
1.00
16.46
C


ATOM
6637
O
ARG
A
433
−45.296
19.890
13.031
1.00
16.31
O


ATOM
6639
N
LEU
A
434
−45.006
21.731
11.724
1.00
16.47
N


ATOM
6640
CA
LEU
A
434
−45.123
22.701
12.800
1.00
15.98
C


ATOM
6642
CB
LEU
A
434
−44.771
24.114
12.303
1.00
15.83
C


ATOM
6645
CG
LEU
A
434
−43.287
24.486
12.218
1.00
14.95
C


ATOM
6647
CD1
LEU
A
434
−43.130
25.918
11.826
1.00
15.09
C


ATOM
6651
CD2
LEU
A
434
−42.600
24.281
13.536
1.00
14.37
C


ATOM
6655
C
LEU
A
434
−46.517
22.660
13.387
1.00
16.19
C


ATOM
6656
O
LEU
A
434
−46.669
22.564
14.604
1.00
15.92
O


ATOM
6658
N
CYS
A
435
−47.529
22.715
12.520
1.00
16.78
N


ATOM
6659
CA
CYS
A
435
−48.936
22.591
12.940
1.00
17.48
C


ATOM
6661
CB
CYS
A
435
−49.870
22.617
11.726
1.00
17.54
C


ATOM
6664
SG
CYS
A
435
−50.110
24.233
10.985
1.00
18.80
S


ATOM
6666
C
CYS
A
435
−49.192
21.296
13.708
1.00
17.84
C


ATOM
6667
O
CYS
A
435
−50.043
21.250
14.597
1.00
17.92
O


ATOM
6669
N
ASN
A
436
−48.446
20.257
13.333
1.00
18.24
N


ATOM
6670
CA
ASN
A
436
−48.603
18.913
13.846
1.00
18.50
C


ATOM
6672
CB
ASN
A
436
−47.936
17.949
12.867
1.00
18.63
C


ATOM
6675
CG
ASN
A
436
−48.156
16.487
13.213
1.00
18.58
C


ATOM
6676
OD1
ASN
A
436
−48.810
16.129
14.185
1.00
18.80
O


ATOM
6677
ND2
ASN
A
436
−47.588
15.633
12.398
1.00
19.29
N


ATOM
6680
C
ASN
A
436
−47.975
18.755
15.210
1.00
18.83
C


ATOM
6681
O
ASN
A
436
−48.551
18.153
16.115
1.00
19.00
O


ATOM
6683
N
ASP
A
437
−46.763
19.255
15.351
1.00
19.29
N


ATOM
6684
CA
ASP
A
437
−46.097
19.179
16.634
1.00
19.62
C


ATOM
6686
CB
ASP
A
437
−44.615
19.522
16.510
1.00
19.45
C


ATOM
6689
CG
ASP
A
437
−43.849
18.480
15.734
1.00
19.36
C


ATOM
6690
OD1
ASP
A
437
−44.491
17.586
15.158
1.00
19.89
O


ATOM
6691
OD2
ASP
A
437
−42.608
18.543
15.699
1.00
19.86
O


ATOM
6692
C
ASP
A
437
−46.799
20.106
17.597
1.00
20.01
C


ATOM
6693
O
ASP
A
437
−46.916
19.790
18.779
1.00
20.30
O


ATOM
6695
N
LEU
A
438
−47.288
21.233
17.092
1.00
20.40
N


ATOM
6696
CA
LEU
A
438
−47.996
22.174
17.940
1.00
21.03
C


ATOM
6698
CB
LEU
A
438
−48.510
23.363
17.126
1.00
21.01
C


ATOM
6701
CG
LEU
A
438
−47.575
24.565
17.078
1.00
20.32
C


ATOM
6703
CD1
LEU
A
438
−47.938
25.524
15.952
1.00
19.14
C


ATOM
6707
CD2
LEU
A
438
−47.611
25.263
18.415
1.00
19.73
C


ATOM
6711
C
LEU
A
438
−49.153
21.496
18.679
1.00
21.81
C


ATOM
6712
O
LEU
A
438
−49.277
21.633
19.902
1.00
21.55
O


ATOM
6714
N
ALA
A
439
−49.973
20.754
17.932
1.00
22.76
N


ATOM
6715
CA
ALA
A
439
−51.138
20.055
18.486
1.00
23.58
C


ATOM
6717
CB
ALA
A
439
−51.905
19.360
17.386
1.00
23.57
C


ATOM
6721
C
ALA
A
439
−50.746
19.042
19.542
1.00
24.47
C


ATOM
6722
O
ALA
A
439
−51.386
18.951
20.575
1.00
24.63
O


ATOM
6724
N
SER
A
440
−49.685
18.291
19.276
1.00
25.78
N


ATOM
6725
CA
SER
A
440
−49.242
17.227
20.168
1.00
26.84
C


ATOM
6727
CB
SER
A
440
−48.566
16.130
19.353
1.00
26.92
C


ATOM
6730
OG
SER
A
440
−47.321
16.582
18.859
1.00
27.46
O


ATOM
6732
C
SER
A
440
−48.270
17.691
21.244
1.00
27.68
C


ATOM
6733
O
SER
A
440
−47.934
16.923
22.132
1.00
28.00
O


ATOM
6735
N
ALA
A
441
−47.822
18.935
21.174
1.00
28.83
N


ATOM
6736
CA
ALA
A
441
−46.760
19.419
22.056
1.00
29.73
C


ATOM
6738
CB
ALA
A
441
−46.529
20.910
21.841
1.00
29.84
C


ATOM
6742
C
ALA
A
441
−46.982
19.132
23.539
1.00
30.57
C


ATOM
6743
O
ALA
A
441
−46.306
18.274
24.093
1.00
30.50
O


ATOM
6745
N
SER
A
442
−47.929
19.827
24.172
1.00
31.90
N


ATOM
6746
CA
SER
A
442
−47.999
19.862
25.654
1.00
32.95
C


ATOM
6748
CB
SER
A
442
−49.043
20.870
26.169
1.00
32.91
C


ATOM
6751
OG
SER
A
442
−50.331
20.614
25.650
1.00
33.50
O


ATOM
6753
C
SER
A
442
−48.219
18.497
26.289
1.00
33.69
C


ATOM
6754
O
SER
A
442
−47.754
18.246
27.397
1.00
33.59
O


ATOM
6756
N
ALA
A
443
−48.922
17.623
25.578
1.00
34.93
N


ATOM
6757
CA
ALA
A
443
−49.050
16.231
25.980
1.00
35.81
C


ATOM
6759
CB
ALA
A
443
−49.981
15.488
25.030
1.00
35.72
C


ATOM
6763
C
ALA
A
443
−47.663
15.580
25.996
1.00
36.71
C


ATOM
6764
O
ALA
A
443
−47.198
15.115
27.047
1.00
36.94
O


ATOM
6766
N
GLU
A
444
−46.999
15.567
24.838
1.00
37.47
N


ATOM
6767
CA
GLU
A
444
−45.688
14.930
24.718
1.00
37.93
C


ATOM
6769
CB
GLU
A
444
−45.164
14.996
23.277
1.00
37.99
C


ATOM
6772
CG
GLU
A
444
−45.952
14.100
22.326
1.00
39.24
C


ATOM
6775
CD
GLU
A
444
−45.419
14.080
20.886
1.00
41.03
C


ATOM
6776
OE1
GLU
A
444
−44.612
14.958
20.510
1.00
42.16
O


ATOM
6777
OE2
GLU
A
444
−45.827
13.178
20.119
1.00
42.36
O


ATOM
6778
C
GLU
A
444
−44.694
15.534
25.708
1.00
38.09
C


ATOM
6779
O
GLU
A
444
−43.924
14.803
26.324
1.00
38.17
O


ATOM
6781
N
ILE
A
445
−44.739
16.851
25.889
1.00
38.41
N


ATOM
6782
CA
ILE
A
445
−43.829
17.530
26.814
1.00
38.75
C


ATOM
6784
CB
ILE
A
445
−43.802
19.065
26.587
1.00
38.69
C


ATOM
6786
CG1
ILE
A
445
−43.314
19.396
25.170
1.00
38.18
C


ATOM
6789
CD1
ILE
A
445
−43.702
20.775
24.712
1.00
37.58
C


ATOM
6793
CG2
ILE
A
445
−42.909
19.753
27.617
1.00
38.26
C


ATOM
6797
C
ILE
A
445
−44.243
17.194
28.246
1.00
39.35
C


ATOM
6798
O
ILE
A
445
−45.039
17.901
28.870
1.00
39.44
O


ATOM
6800
N
ALA
A
446
−43.696
16.092
28.750
1.00
40.02
N


ATOM
6801
CA
ALA
A
446
−44.082
15.540
30.045
1.00
40.51
C


ATOM
6803
CB
ALA
A
446
−43.815
16.552
31.170
1.00
40.55
C


ATOM
6807
C
ALA
A
446
−45.559
15.130
30.029
1.00
40.86
C


ATOM
6808
O
ALA
A
446
−46.407
16.021
30.121
1.00
40.77
O


ATOM
6810
N
ARG
A
447
−45.925
13.842
29.899
1.00
41.31
N


ATOM
6811
CA
ARG
A
447
−45.072
12.633
29.691
1.00
41.58
C


ATOM
6813
CB
ARG
A
447
−45.272
12.092
28.258
1.00
41.84
C


ATOM
6816
CG
ARG
A
447
−46.667
11.495
27.991
1.00
42.69
C


ATOM
6819
CD
ARG
A
447
−46.778
10.901
26.582
1.00
43.92
C


ATOM
6822
NE
ARG
A
447
−47.764
11.589
25.744
1.00
45.34
N


ATOM
6824
CZ
ARG
A
447
−47.887
11.435
24.420
1.00
46.56
C


ATOM
6825
NH1
ARG
A
447
−47.077
10.623
23.742
1.00
46.71
N


ATOM
6828
NH2
ARG
A
447
−48.828
12.107
23.757
1.00
46.97
N


ATOM
6831
C
ARG
A
447
−43.581
12.728
30.054
1.00
41.38
C


ATOM
6832
O
ARG
A
447
−43.231
12.747
31.238
1.00
41.92
O


ATOM
6834
N
GLY
A
448
−42.710
12.736
29.051
1.00
40.88
N


ATOM
6835
CA
GLY
A
448
−41.312
13.128
29.234
1.00
40.44
C


ATOM
6838
C
GLY
A
448
−40.579
13.316
27.915
1.00
40.08
C


ATOM
6839
O
GLY
A
448
−39.364
13.488
27.901
1.00
40.05
O


ATOM
6841
N
GLU
A
449
−41.323
13.332
26.809
1.00
39.56
N


ATOM
6842
CA
GLU
A
449
−40.750
13.132
25.486
1.00
39.19
C


ATOM
6844
CB
GLU
A
449
−41.827
12.668
24.502
1.00
39.52
C


ATOM
6847
CG
GLU
A
449
−42.403
11.290
24.810
1.00
40.61
C


ATOM
6850
CD
GLU
A
449
−43.348
10.782
23.715
1.00
42.21
C


ATOM
6851
OE1
GLU
A
449
−43.068
11.019
22.503
1.00
41.83
O


ATOM
6852
OE2
GLU
A
449
−44.368
10.141
24.082
1.00
42.41
O


ATOM
6853
C
GLU
A
449
−40.037
14.365
24.921
1.00
38.34
C


ATOM
6854
O
GLU
A
449
−40.511
15.497
25.031
1.00
38.01
O


ATOM
6856
N
THR
A
450
−38.904
14.106
24.279
1.00
37.37
N


ATOM
6857
CA
THR
A
450
−38.047
15.138
23.726
1.00
36.37
C


ATOM
6859
CB
THR
A
450
−36.607
14.985
24.285
1.00
36.39
C


ATOM
6861
OG1
THR
A
450
−35.846
16.153
23.982
1.00
36.63
O


ATOM
6863
CG2
THR
A
450
−35.888
13.749
23.706
1.00
36.52
C


ATOM
6867
C
THR
A
450
−38.013
15.100
22.190
1.00
35.36
C


ATOM
6868
O
THR
A
450
−37.175
15.764
21.583
1.00
35.43
O


ATOM
6870
N
ALA
A
451
−38.917
14.338
21.563
1.00
33.98
N


ATOM
6871
CA
ALA
A
451
−38.920
14.182
20.096
1.00
32.81
C


ATOM
6873
CB
ALA
A
451
−39.030
12.708
19.708
1.00
32.99
C


ATOM
6877
C
ALA
A
451
−40.043
14.987
19.459
1.00
31.46
C


ATOM
6878
O
ALA
A
451
−41.050
14.432
18.996
1.00
31.06
O


ATOM
6880
N
ASN
A
452
−39.848
16.302
19.432
1.00
29.88
N


ATOM
6881
CA
ASN
A
452
−40.881
17.225
18.973
1.00
28.81
C


ATOM
6883
CB
ASN
A
452
−41.957
17.329
20.051
1.00
28.57
C


ATOM
6886
CG
ASN
A
452
−42.969
18.380
19.757
1.00
28.30
C


ATOM
6887
OD1
ASN
A
452
−42.622
19.517
19.468
1.00
29.35
O


ATOM
6888
ND2
ASN
A
452
−44.236
18.018
19.836
1.00
28.36
N


ATOM
6891
C
ASN
A
452
−40.285
18.590
18.641
1.00
27.76
C


ATOM
6892
O
ASN
A
452
−39.365
19.018
19.296
1.00
28.04
O


ATOM
6894
N
SER
A
453
−40.807
19.269
17.630
1.00
26.77
N


ATOM
6895
CA
SER
A
453
−40.226
20.533
17.182
1.00
26.38
C


ATOM
6897
CB
SER
A
453
−40.912
21.015
15.903
1.00
26.40
C


ATOM
6900
OG
SER
A
453
−40.796
20.044
14.876
1.00
25.79
O


ATOM
6902
C
SER
A
453
−40.253
21.643
18.233
1.00
26.12
C


ATOM
6903
O
SER
A
453
−39.280
22.361
18.385
1.00
25.97
O


ATOM
6905
N
VAL
A
454
−41.368
21.784
18.942
1.00
26.15
N


ATOM
6906
CA
VAL
A
454
−41.518
22.780
20.022
1.00
26.21
C


ATOM
6908
CB
VAL
A
454
−42.975
22.818
20.532
1.00
26.04
C


ATOM
6910
CG1
VAL
A
454
−43.122
23.787
21.694
1.00
25.24
C


ATOM
6914
CG2
VAL
A
454
−43.913
23.190
19.401
1.00
26.32
C


ATOM
6918
C
VAL
A
454
−40.617
22.451
21.211
1.00
26.63
C


ATOM
6919
O
VAL
A
454
−40.173
23.328
21.959
1.00
26.53
O


ATOM
6921
N
SER
A
455
−40.374
21.160
21.380
1.00
27.21
N


ATOM
6922
CA
SER
A
455
−39.541
20.651
22.437
1.00
27.60
C


ATOM
6924
CB
SER
A
455
−39.677
19.141
22.490
1.00
27.31
C


ATOM
6927
OG
SER
A
455
−38.922
18.625
23.545
1.00
28.13
O


ATOM
6929
C
SER
A
455
−38.096
21.045
22.181
1.00
28.29
C


ATOM
6930
O
SER
A
455
−37.445
21.628
23.043
1.00
28.63
O


ATOM
6932
N
CYS
A
456
−37.599
20.748
20.988
1.00
29.04
N


ATOM
6933
CA
CYS
A
456
−36.219
21.082
20.640
1.00
29.65
C


ATOM
6935
CB
CYS
A
456
−35.868
20.535
19.256
1.00
29.52
C


ATOM
6938
SG
CYS
A
456
−35.959
18.734
19.163
1.00
29.71
S


ATOM
6940
C
CYS
A
456
−35.955
22.589
20.710
1.00
30.26
C


ATOM
6941
O
CYS
A
456
−34.887
23.007
21.162
1.00
30.49
O


ATOM
6943
N
TYR
A
457
−36.924
23.399
20.283
1.00
30.88
N


ATOM
6944
CA
TYR
A
457
−36.767
24.850
20.308
1.00
31.45
C


ATOM
6946
CB
TYR
A
457
−37.967
25.557
19.648
1.00
31.55
C


ATOM
6949
CG
TYR
A
457
−37.691
26.991
19.178
1.00
32.09
C


ATOM
6950
CD1
TYR
A
457
−37.378
27.269
17.843
1.00
31.69
C


ATOM
6952
CE1
TYR
A
457
−37.128
28.569
17.418
1.00
31.73
C


ATOM
6954
CZ
TYR
A
457
−37.186
29.613
18.328
1.00
32.84
C


ATOM
6955
OH
TYR
A
457
−36.945
30.917
17.927
1.00
33.81
O


ATOM
6957
CE2
TYR
A
457
−37.492
29.364
19.658
1.00
32.72
C


ATOM
6959
CD2
TYR
A
457
−37.746
28.064
20.074
1.00
32.44
C


ATOM
6961
C
TYR
A
457
−36.571
25.295
21.758
1.00
31.99
C


ATOM
6962
O
TYR
A
457
−35.648
26.053
22.052
1.00
31.98
O


ATOM
6964
N
MET
A
458
−37.419
24.799
22.661
1.00
32.76
N


ATOM
6965
CA
MET
A
458
−37.211
24.987
24.105
1.00
33.37
C


ATOM
6967
CB
MET
A
458
−38.151
24.097
24.921
1.00
33.43
C


ATOM
6970
CG
MET
A
458
−39.570
24.593
25.059
1.00
33.70
C


ATOM
6973
SD
MET
A
458
−40.641
23.312
25.737
1.00
34.59
S


ATOM
6974
CE
MET
A
458
−39.709
22.763
27.179
1.00
34.71
C


ATOM
6978
C
MET
A
458
−35.784
24.641
24.517
1.00
33.78
C


ATOM
6979
O
MET
A
458
−35.101
25.437
25.151
1.00
33.73
O


ATOM
6981
N
ARG
A
459
−35.347
23.445
24.145
1.00
34.46
N


ATOM
6982
CA
ARG
A
459
−34.051
22.926
24.581
1.00
35.15
C


ATOM
6984
CB
ARG
A
459
−33.876
21.447
24.171
1.00
35.68
C


ATOM
6987
CG
ARG
A
459
−32.494
20.864
24.500
1.00
37.23
C


ATOM
6990
CD
ARG
A
459
−32.491
19.345
24.752
1.00
39.80
C


ATOM
6993
NE
ARG
A
459
−33.140
18.538
23.711
1.00
42.88
N


ATOM
6995
CZ
ARG
A
459
−32.704
18.407
22.453
1.00
45.43
C


ATOM
6996
NH1
ARG
A
459
−31.615
19.062
22.035
1.00
47.50
N


ATOM
6999
NH2
ARG
A
459
−33.366
17.629
21.595
1.00
44.77
N


ATOM
7002
C
ARG
A
459
−32.878
23.749
24.072
1.00
34.92
C


ATOM
7003
O
ARG
A
459
−32.007
24.109
24.849
1.00
35.06
O


ATOM
7005
N
THR
A
460
−32.854
24.047
22.778
1.00
34.96
N


ATOM
7006
CA
THR
A
460
−31.674
24.678
22.163
1.00
34.91
C


ATOM
7008
CB
THR
A
460
−31.494
24.263
20.680
1.00
34.88
C


ATOM
7010
OG1
THR
A
460
−32.330
25.067
19.841
1.00
34.39
O


ATOM
7012
CG2
THR
A
460
−31.825
22.776
20.488
1.00
35.44
C


ATOM
7016
C
THR
A
460
−31.672
26.210
22.258
1.00
34.78
C


ATOM
7017
O
THR
A
460
−30.673
26.837
21.911
1.00
34.92
O


ATOM
7019
N
LYS
A
461
−32.781
26.806
22.701
1.00
34.41
N


ATOM
7020
CA
LYS
A
461
−32.811
28.231
23.039
1.00
34.25
C


ATOM
7022
CB
LYS
A
461
−33.921
28.947
22.265
1.00
34.56
C


ATOM
7025
CG
LYS
A
461
−33.717
28.986
20.750
1.00
35.84
C


ATOM
7028
CD
LYS
A
461
−32.519
29.859
20.347
1.00
37.64
C


ATOM
7031
CE
LYS
A
461
−32.232
29.804
18.838
1.00
38.44
C


ATOM
7034
NZ
LYS
A
461
−33.141
30.671
18.027
1.00
38.31
N


ATOM
7038
C
LYS
A
461
−32.974
28.476
24.544
1.00
33.73
C


ATOM
7039
O
LYS
A
461
−32.994
29.626
24.983
1.00
33.23
O


ATOM
7041
N
GLY
A
462
−33.078
27.395
25.321
1.00
33.48
N


ATOM
7042
CA
GLY
A
462
−33.173
27.464
26.784
1.00
33.23
C


ATOM
7045
C
GLY
A
462
−34.332
28.320
27.239
1.00
32.95
C


ATOM
7046
O
GLY
A
462
−34.144
29.258
28.004
1.00
33.17
O


ATOM
7048
N
ILE
A
463
−35.528
28.000
26.757
1.00
32.52
N


ATOM
7049
CA
ILE
A
463
−36.694
28.843
26.971
1.00
32.32
C


ATOM
7051
CB
ILE
A
463
−37.006
29.724
25.734
1.00
32.47
C


ATOM
7053
CG1
ILE
A
463
−37.152
28.866
24.463
1.00
32.41
C


ATOM
7056
CD1
ILE
A
463
−37.359
29.675
23.191
1.00
32.02
C


ATOM
7060
CG2
ILE
A
463
−35.937
30.810
25.571
1.00
32.44
C


ATOM
7064
C
ILE
A
463
−37.902
28.006
27.309
1.00
32.15
C


ATOM
7065
O
ILE
A
463
−37.886
26.799
27.145
1.00
32.01
O


ATOM
7067
N
SER
A
464
−38.950
28.670
27.780
1.00
32.27
N


ATOM
7068
CA
SER
A
464
−40.163
28.006
28.239
1.00
32.52
C


ATOM
7070
CB
SER
A
464
−40.964
28.974
29.110
1.00
32.65
C


ATOM
7073
OG
SER
A
464
−41.112
30.224
28.457
1.00
32.69
O


ATOM
7075
C
SER
A
464
−41.036
27.522
27.079
1.00
32.53
C


ATOM
7076
O
SER
A
464
−40.968
28.069
25.986
1.00
32.62
O


ATOM
7078
N
GLU
A
465
−41.857
26.500
27.332
1.00
32.47
N


ATOM
7079
CA
GLU
A
465
−42.836
26.010
26.353
1.00
32.33
C


ATOM
7081
CB
GLU
A
465
−43.689
24.868
26.935
1.00
32.34
C


ATOM
7084
CG
GLU
A
465
−44.756
24.312
25.974
1.00
32.37
C


ATOM
7087
CD
GLU
A
465
−45.675
23.279
26.611
1.00
32.47
C


ATOM
7088
OE1
GLU
A
465
−45.297
22.659
27.630
1.00
31.63
O


ATOM
7089
OE2
GLU
A
465
−46.785
23.086
26.074
1.00
32.77
O


ATOM
7090
C
GLU
A
465
−43.758
27.124
25.864
1.00
32.33
C


ATOM
7091
O
GLU
A
465
−44.078
27.183
24.676
1.00
32.60
O


ATOM
7093
N
GLU
A
466
−44.196
28.001
26.767
1.00
32.08
N


ATOM
7094
CA
GLU
A
466
−45.085
29.097
26.380
1.00
31.79
C


ATOM
7096
CB
GLU
A
466
−45.606
29.832
27.624
1.00
31.91
C


ATOM
7099
CG
GLU
A
466
−46.503
31.041
27.304
1.00
32.82
C


ATOM
7102
CD
GLU
A
466
−47.426
31.472
28.452
1.00
33.67
C


ATOM
7103
OE1
GLU
A
466
−47.519
30.756
29.478
1.00
35.09
O


ATOM
7104
OE2
GLU
A
466
−48.077
32.533
28.312
1.00
33.12
O


ATOM
7105
C
GLU
A
466
−44.392
30.052
25.386
1.00
31.13
C


ATOM
7106
O
GLU
A
466
−45.032
30.603
24.492
1.00
30.87
O


ATOM
7108
N
LEU
A
467
−43.077
30.194
25.531
1.00
30.57
N


ATOM
7109
CA
LEU
A
467
−42.265
31.102
24.708
1.00
30.18
C


ATOM
7111
CB
LEU
A
467
−41.055
31.604
25.524
1.00
30.38
C


ATOM
7114
CG
LEU
A
467
−40.674
33.087
25.463
1.00
30.39
C


ATOM
7116
CD1
LEU
A
467
−41.608
33.900
26.362
1.00
30.23
C


ATOM
7120
CD2
LEU
A
467
−39.214
33.308
25.872
1.00
30.31
C


ATOM
7124
C
LEU
A
467
−41.773
30.401
23.439
1.00
29.47
C


ATOM
7125
O
LEU
A
467
−41.660
31.010
22.382
1.00
29.17
O


ATOM
7127
N
ALA
A
468
−41.445
29.121
23.562
1.00
28.93
N


ATOM
7128
CA
ALA
A
468
−41.095
28.310
22.404
1.00
28.45
C


ATOM
7130
CB
ALA
A
468
−40.613
26.935
22.830
1.00
28.10
C


ATOM
7134
C
ALA
A
468
−42.306
28.193
21.494
1.00
28.08
C


ATOM
7135
O
ALA
A
468
−42.179
28.321
20.285
1.00
28.24
O


ATOM
7137
N
THR
A
469
−43.479
27.964
22.080
1.00
27.58
N


ATOM
7138
CA
THR
A
469
−44.719
27.870
21.322
1.00
27.26
C


ATOM
7140
CB
THR
A
469
−45.928
27.710
22.261
1.00
27.28
C


ATOM
7142
OG1
THR
A
469
−46.063
26.330
22.627
1.00
27.55
O


ATOM
7144
CG2
THR
A
469
−47.222
28.185
21.597
1.00
27.34
C


ATOM
7148
C
THR
A
469
−44.916
29.099
20.449
1.00
27.10
C


ATOM
7149
O
THR
A
469
−45.176
28.989
19.250
1.00
27.11
O


ATOM
7151
N
GLU
A
470
−44.774
30.267
21.061
1.00
26.88
N


ATOM
7152
CA
GLU
A
470
−44.944
31.542
20.376
1.00
26.84
C


ATOM
7154
CB
GLU
A
470
−44.832
32.663
21.400
1.00
27.07
C


ATOM
7157
CG
GLU
A
470
−45.357
34.003
20.958
1.00
28.47
C


ATOM
7160
CD
GLU
A
470
−45.140
35.087
22.008
1.00
30.51
C


ATOM
7161
OE1
GLU
A
470
−45.029
34.775
23.221
1.00
31.53
O


ATOM
7162
OE2
GLU
A
470
−45.083
36.269
21.608
1.00
32.59
O


ATOM
7163
C
GLU
A
470
−43.926
31.750
19.239
1.00
26.48
C


ATOM
7164
O
GLU
A
470
−44.261
32.296
18.184
1.00
26.29
O


ATOM
7166
N
SER
A
471
−42.686
31.316
19.452
1.00
26.12
N


ATOM
7167
CA
SER
A
471
−41.660
31.386
18.408
1.00
25.85
C


ATOM
7169
CB
SER
A
471
−40.296
30.933
18.941
1.00
25.96
C


ATOM
7172
OG
SER
A
471
−39.656
31.939
19.711
1.00
26.53
O


ATOM
7174
C
SER
A
471
−42.036
30.529
17.208
1.00
25.35
C


ATOM
7175
O
SER
A
471
−41.761
30.899
16.067
1.00
25.43
O


ATOM
7177
N
VAL
A
472
−42.653
29.381
17.482
1.00
24.95
N


ATOM
7178
CA
VAL
A
472
−43.097
28.451
16.438
1.00
24.65
C


ATOM
7180
CB
VAL
A
472
−43.485
27.055
17.024
1.00
24.57
C


ATOM
7182
CG1
VAL
A
472
−44.257
26.222
16.016
1.00
23.23
C


ATOM
7186
CG2
VAL
A
472
−42.232
26.309
17.494
1.00
23.83
C


ATOM
7190
C
VAL
A
472
−44.252
29.039
15.631
1.00
24.71
C


ATOM
7191
O
VAL
A
472
−44.369
28.776
14.440
1.00
24.63
O


ATOM
7193
N
MET
A
473
−45.073
29.866
16.269
1.00
24.79
N


ATOM
7194
CA
MET
A
473
−46.143
30.591
15.565
1.00
24.94
C


ATOM
7196
CB
MET
A
473
−47.059
31.266
16.576
1.00
25.11
C


ATOM
7199
CG
MET
A
473
−47.683
30.335
17.560
1.00
25.11
C


ATOM
7202
SD
MET
A
473
−48.967
29.391
16.780
1.00
25.35
S


ATOM
7203
CE
MET
A
473
−50.064
29.163
18.189
1.00
26.11
C


ATOM
7207
C
MET
A
473
−45.613
31.672
14.605
1.00
24.86
C


ATOM
7208
O
MET
A
473
−46.132
31.849
13.513
1.00
24.57
O


ATOM
7210
N
ASN
A
474
−44.589
32.405
15.032
1.00
24.89
N


ATOM
7211
CA
ASN
A
474
−43.951
33.383
14.166
1.00
25.00
C


ATOM
7213
CB
ASN
A
474
−43.009
34.278
14.966
1.00
25.12
C


ATOM
7216
CG
ASN
A
474
−43.700
34.966
16.127
1.00
25.77
C


ATOM
7217
OD1
ASN
A
474
−43.058
35.312
17.114
1.00
26.96
O


ATOM
7218
ND2
ASN
A
474
−45.015
35.163
16.021
1.00
26.31
N


ATOM
7221
C
ASN
A
474
−43.195
32.707
13.024
1.00
24.84
C


ATOM
7222
O
ASN
A
474
−42.979
33.313
11.973
1.00
25.07
O


ATOM
7224
N
LEU
A
475
−42.792
31.455
13.227
1.00
24.46
N


ATOM
7225
CA
LEU
A
475
−42.218
30.671
12.142
1.00
24.06
C


ATOM
7227
CB
LEU
A
475
−41.596
29.367
12.653
1.00
24.27
C


ATOM
7230
CG
LEU
A
475
−40.307
29.072
11.886
1.00
25.08
C


ATOM
7232
CD1
LEU
A
475
−39.207
30.000
12.419
1.00
25.89
C


ATOM
7236
CD2
LEU
A
475
−39.887
27.622
11.985
1.00
25.33
C


ATOM
7240
C
LEU
A
475
−43.278
30.365
11.085
1.00
23.26
C


ATOM
7241
O
LEU
A
475
−43.018
30.479
9.884
1.00
22.90
O


ATOM
7243
N
ILE
A
476
−44.471
29.978
11.534
1.00
22.53
N


ATOM
7244
CA
ILE
A
476
−45.544
29.632
10.606
1.00
21.93
C


ATOM
7246
CB
ILE
A
476
−46.773
29.017
11.308
1.00
21.58
C


ATOM
7248
CG1
ILE
A
476
−46.499
27.550
11.664
1.00
21.32
C


ATOM
7251
CD1
ILE
A
476
−47.552
26.902
12.598
1.00
20.33
C


ATOM
7255
CG2
ILE
A
476
−47.994
29.104
10.428
1.00
20.46
C


ATOM
7259
C
ILE
A
476
−45.926
30.887
9.853
1.00
22.07
C


ATOM
7260
O
ILE
A
476
−46.007
30.869
8.626
1.00
22.47
O


ATOM
7262
N
ASP
A
477
−46.122
31.982
10.584
1.00
21.81
N


ATOM
7263
CA
ASP
A
477
−46.483
33.245
9.970
1.00
21.56
C


ATOM
7265
CB
ASP
A
477
−46.643
34.337
11.032
1.00
21.89
C


ATOM
7268
CG
ASP
A
477
−47.962
34.217
11.817
1.00
23.39
C


ATOM
7269
OD1
ASP
A
477
−48.854
33.441
11.375
1.00
24.41
O


ATOM
7270
OD2
ASP
A
477
−48.103
34.902
12.875
1.00
23.80
O


ATOM
7271
C
ASP
A
477
−45.425
33.626
8.947
1.00
21.06
C


ATOM
7272
O
ASP
A
477
−45.759
33.913
7.795
1.00
20.78
O


ATOM
7274
N
GLU
A
478
−44.156
33.591
9.361
1.00
20.63
N


ATOM
7275
CA
GLU
A
478
−43.027
33.919
8.467
1.00
20.45
C


ATOM
7277
CB
GLU
A
478
−41.680
33.793
9.200
1.00
20.66
C


ATOM
7280
CG
GLU
A
478
−40.422
34.044
8.339
1.00
22.27
C


ATOM
7283
CD
GLU
A
478
−39.107
33.579
9.018
1.00
24.72
C


ATOM
7284
OE1
GLU
A
478
−38.553
34.367
9.817
1.00
26.19
O


ATOM
7285
OE2
GLU
A
478
−38.619
32.442
8.745
1.00
25.66
O


ATOM
7286
C
GLU
A
478
−43.041
33.042
7.217
1.00
19.54
C


ATOM
7287
O
GLU
A
478
−42.879
33.544
6.102
1.00
19.02
O


ATOM
7289
N
THR
A
479
−43.250
31.743
7.413
1.00
18.76
N


ATOM
7290
CA
THR
A
479
−43.358
30.808
6.294
1.00
18.45
C


ATOM
7292
CB
THR
A
479
−43.503
29.339
6.774
1.00
18.26
C


ATOM
7294
OG1
THR
A
479
−42.334
28.955
7.494
1.00
17.30
O


ATOM
7296
CG2
THR
A
479
−43.669
28.394
5.592
1.00
17.93
C


ATOM
7300
C
THR
A
479
−44.504
31.173
5.314
1.00
18.39
C


ATOM
7301
O
THR
A
479
−44.280
31.200
4.103
1.00
18.58
O


ATOM
7303
N
TRP
A
480
−45.709
31.457
5.818
1.00
17.85
N


ATOM
7304
CA
TRP
A
480
−46.801
31.909
4.942
1.00
17.44
C


ATOM
7306
CB
TRP
A
480
−48.086
32.225
5.728
1.00
17.67
C


ATOM
7309
CG
TRP
A
480
−48.969
31.042
5.888
1.00
17.09
C


ATOM
7310
CD1
TRP
A
480
−48.996
30.195
6.936
1.00
16.76
C


ATOM
7312
NE1
TRP
A
480
−49.914
29.216
6.724
1.00
17.08
N


ATOM
7314
CE2
TRP
A
480
−50.501
29.410
5.507
1.00
17.86
C


ATOM
7315
CD2
TRP
A
480
−49.930
30.559
4.954
1.00
17.15
C


ATOM
7316
CE3
TRP
A
480
−50.356
30.980
3.696
1.00
18.31
C


ATOM
7318
CZ3
TRP
A
480
−51.337
30.244
3.039
1.00
19.10
C


ATOM
7320
CH2
TRP
A
480
−51.897
29.107
3.622
1.00
18.83
C


ATOM
7322
CZ2
TRP
A
480
−51.493
28.673
4.855
1.00
18.86
C


ATOM
7324
C
TRP
A
480
−46.426
33.124
4.097
1.00
17.10
C


ATOM
7325
O
TRP
A
480
−46.824
33.215
2.943
1.00
17.22
O


ATOM
7327
N
LYS
A
481
−45.675
34.062
4.659
1.00
16.60
N


ATOM
7328
CA
LYS
A
481
−45.275
35.215
3.886
1.00
16.23
C


ATOM
7330
CB
LYS
A
481
−44.566
36.243
4.747
1.00
16.42
C


ATOM
7333
CG
LYS
A
481
−45.417
36.954
5.769
1.00
16.42
C


ATOM
7336
CD
LYS
A
481
−44.555
37.979
6.505
1.00
16.40
C


ATOM
7339
CE
LYS
A
481
−45.199
38.504
7.782
1.00
16.66
C


ATOM
7342
NZ
LYS
A
481
−44.184
38.717
8.846
1.00
16.72
N


ATOM
7346
C
LYS
A
481
−44.357
34.782
2.767
1.00
15.94
C


ATOM
7347
O
LYS
A
481
−44.451
35.291
1.674
1.00
16.09
O


ATOM
7349
N
LYS
A
482
−43.461
33.849
3.034
1.00
15.98
N


ATOM
7350
CA
LYS
A
482
−42.559
33.369
1.996
1.00
16.30
C


ATOM
7352
CB
LYS
A
482
−41.409
32.563
2.594
1.00
16.51
C


ATOM
7355
CG
LYS
A
482
−40.354
33.445
3.286
1.00
17.46
C


ATOM
7358
CD
LYS
A
482
−39.486
32.647
4.241
1.00
18.48
C


ATOM
7361
CE
LYS
A
482
−38.625
33.548
5.096
1.00
18.94
C


ATOM
7364
NZ
LYS
A
482
−37.865
32.773
6.129
1.00
20.40
N


ATOM
7368
C
LYS
A
482
−43.296
32.561
.938
1.00
16.40
C


ATOM
7369
O
LYS
A
482
−42.941
32.614
−.229
1.00
16.85
O


ATOM
7371
N
MET
A
483
−44.328
31.824
1.332
1.00
16.57
N


ATOM
7372
CA
MET
A
483
−45.149
31.100
.366
1.00
16.67
C


ATOM
7374
CB
MET
A
483
−46.128
30.156
1.057
1.00
16.55
C


ATOM
7377
CG
MET
A
483
−45.496
28.923
1.675
1.00
16.50
C


ATOM
7380
SD
MET
A
483
−46.715
27.684
2.194
1.00
17.39
S


ATOM
7381
CE
MET
A
483
−47.937
28.704
3.025
1.00
17.27
C


ATOM
7385
C
MET
A
483
−45.928
32.069
−.495
1.00
17.06
C


ATOM
7386
O
MET
A
483
−46.027
31.867
−1.688
1.00
17.17
O


ATOM
7388
N
ASN
A
484
−46.483
33.110
.118
1.00
17.72
N


ATOM
7389
CA
ASN
A
484
−47.305
34.093
−.587
1.00
18.35
C


ATOM
7391
CB
ASN
A
484
−47.861
35.129
.397
1.00
18.26
C


ATOM
7394
CG
ASN
A
484
−48.994
34.601
1.248
1.00
17.35
C


ATOM
7395
OD1
ASN
A
484
−49.597
33.577
.934
1.00
17.54
O


ATOM
7396
ND2
ASN
A
484
−49.304
35.317
2.331
1.00
14.10
N


ATOM
7399
C
ASN
A
484
−46.541
34.839
−1.677
1.00
19.51
C


ATOM
7400
O
ASN
A
484
−47.123
35.250
−2.685
1.00
19.49
O


ATOM
7402
N
LYS
A
485
−45.243
35.035
−1.463
1.00
20.86
N


ATOM
7403
CA
LYS
A
485
−44.394
35.681
−2.456
1.00
22.12
C


ATOM
7405
CB
LYS
A
485
−43.070
36.092
−1.823
1.00
22.08
C


ATOM
7408
CG
LYS
A
485
−42.229
37.060
−2.641
1.00
23.09
C


ATOM
7411
CD
LYS
A
485
−40.783
37.072
−2.109
1.00
25.38
C


ATOM
7414
CE
LYS
A
485
−40.098
38.460
−2.135
1.00
26.12
C


ATOM
7417
NZ
LYS
A
485
−38.943
38.555
−3.086
1.00
26.61
N


ATOM
7421
C
LYS
A
485
−44.164
34.743
−3.656
1.00
23.36
C


ATOM
7422
O
LYS
A
485
−44.120
35.191
−4.802
1.00
23.00
O


ATOM
7424
N
GLU
A
486
−44.027
33.442
−3.400
1.00
24.99
N


ATOM
7425
CA
GLU
A
486
−43.902
32.479
−4.491
1.00
26.35
C


ATOM
7427
CB
GLU
A
486
−43.627
31.061
−3.978
1.00
26.55
C


ATOM
7430
CG
GLU
A
486
−42.985
30.130
−5.033
1.00
28.29
C


ATOM
7433
CD
GLU
A
486
−41.466
30.324
−5.191
1.00
31.11
C


ATOM
7434
OE1
GLU
A
486
−40.981
30.466
−6.341
1.00
32.07
O


ATOM
7435
OE2
GLU
A
486
−40.744
30.335
−4.159
1.00
33.04
O


ATOM
7436
C
GLU
A
486
−45.157
32.501
−5.362
1.00
27.13
C


ATOM
7437
O
GLU
A
486
−45.064
32.618
−6.583
1.00
27.57
O


ATOM
7439
N
LYS
A
487
−46.325
32.422
−4.739
1.00
28.12
N


ATOM
7440
CA
LYS
A
487
−47.582
32.378
−5.485
1.00
29.12
C


ATOM
7442
CB
LYS
A
487
−48.788
32.260
−4.542
1.00
29.21
C


ATOM
7445
CG
LYS
A
487
−50.167
32.296
−5.235
1.00
28.57
C


ATOM
7448
CD
LYS
A
487
−50.403
31.040
−6.036
1.00
27.91
C


ATOM
7451
CE
LYS
A
487
−51.615
31.141
−6.936
1.00
28.38
C


ATOM
7454
NZ
LYS
A
487
−52.874
31.460
−6.211
1.00
28.03
N


ATOM
7458
C
LYS
A
487
−47.756
33.603
−6.352
1.00
30.18
C


ATOM
7459
O
LYS
A
487
−48.308
33.514
−7.446
1.00
30.21
O


ATOM
7461
N
LEU
A
488
−47.295
34.743
−5.844
1.00
31.64
N


ATOM
7462
CA
LEU
A
488
−47.422
36.026
−6.532
1.00
32.65
C


ATOM
7464
CB
LEU
A
488
−47.426
37.144
−5.494
1.00
32.43
C


ATOM
7467
CG
LEU
A
488
−48.091
38.446
−5.907
1.00
32.50
C


ATOM
7469
CD1
LEU
A
488
−49.593
38.288
−5.943
1.00
32.66
C


ATOM
7473
CD2
LEU
A
488
−47.707
39.554
−4.943
1.00
33.38
C


ATOM
7477
C
LEU
A
488
−46.286
36.242
−7.542
1.00
33.99
C


ATOM
7478
O
LEU
A
488
−46.536
36.539
−8.705
1.00
33.72
O


ATOM
7480
N
GLY
A
489
−45.046
36.045
−7.091
1.00
35.85
N


ATOM
7481
CA
GLY
A
489
−43.845
36.361
−7.874
1.00
37.37
C


ATOM
7484
C
GLY
A
489
−43.278
35.221
−8.709
1.00
38.76
C


ATOM
7485
O
GLY
A
489
−42.414
34.467
−8.250
1.00
39.06
O


ATOM
7487
N
GLY
A
490
−43.760
35.119
−9.947
1.00
40.26
N


ATOM
7488
CA
GLY
A
490
−43.285
34.130
−10.927
1.00
41.03
C


ATOM
7491
C
GLY
A
490
−42.193
33.194
−10.436
1.00
41.61
C


ATOM
7492
O
GLY
A
490
−41.010
33.547
−10.423
1.00
41.62
O


ATOM
7494
N
SER
A
491
−42.590
31.996
−10.023
1.00
42.17
N


ATOM
7495
CA
SER
A
491
−41.619
30.962
−9.662
1.00
42.54
C


ATOM
7497
CB
SER
A
491
−42.279
29.909
−8.741
1.00
42.63
C


ATOM
7500
OG
SER
A
491
−43.451
29.345
−9.294
1.00
42.44
O


ATOM
7502
C
SER
A
491
−41.032
30.349
−10.952
1.00
42.50
C


ATOM
7503
O
SER
A
491
−41.117
30.961
−12.030
1.00
42.57
O


ATOM
7505
N
LEU
A
492
−40.405
29.177
−10.843
1.00
42.18
N


ATOM
7506
CA
LEU
A
492
−40.185
28.333
−12.021
1.00
41.96
C


ATOM
7508
CB
LEU
A
492
−39.110
27.270
−11.782
1.00
42.39
C


ATOM
7511
CG
LEU
A
492
−37.695
27.671
−11.353
1.00
44.21
C


ATOM
7513
CD1
LEU
A
492
−36.783
26.438
−11.498
1.00
45.26
C


ATOM
7517
CD2
LEU
A
492
−37.120
28.896
−12.129
1.00
45.51
C


ATOM
7521
C
LEU
A
492
−41.479
27.610
−12.356
1.00
40.88
C


ATOM
7522
O
LEU
A
492
−41.713
27.244
−13.504
1.00
40.78
O


ATOM
7524
N
PHE
A
493
−42.308
27.409
−11.339
1.00
39.61
N


ATOM
7525
CA
PHE
A
493
−43.500
26.595
−11.460
1.00
38.85
C


ATOM
7527
CB
PHE
A
493
−43.783
25.911
−10.124
1.00
38.62
C


ATOM
7530
CG
PHE
A
493
−42.725
24.937
−9.713
1.00
37.16
C


ATOM
7531
CD1
PHE
A
493
−42.901
23.587
−9.916
1.00
35.26
C


ATOM
7533
CE1
PHE
A
493
−41.934
22.698
−9.546
1.00
34.86
C


ATOM
7535
CZ
PHE
A
493
−40.769
23.143
−8.966
1.00
35.09
C


ATOM
7537
CE2
PHE
A
493
−40.574
24.482
−8.759
1.00
35.45
C


ATOM
7539
CD2
PHE
A
493
−41.549
25.374
−9.130
1.00
36.36
C


ATOM
7541
C
PHE
A
493
−44.714
27.412
−11.890
1.00
38.62
C


ATOM
7542
O
PHE
A
493
−44.756
28.621
−11.702
1.00
38.86
O


ATOM
7544
N
ALA
A
494
−45.698
26.731
−12.469
1.00
38.32
N


ATOM
7545
CA
ALA
A
494
−46.977
27.337
−12.843
1.00
38.09
C


ATOM
7547
CB
ALA
A
494
−47.658
26.486
−13.906
1.00
38.17
C


ATOM
7551
C
ALA
A
494
−47.891
27.479
−11.623
1.00
37.76
C


ATOM
7552
O
ALA
A
494
−48.039
26.541
−10.845
1.00
38.15
O


ATOM
7554
N
LYS
A
495
−48.541
28.629
−11.484
1.00
37.15
N


ATOM
7555
CA
LYS
A
495
−49.321
28.947
−10.270
1.00
36.53
C


ATOM
7557
CB
LYS
A
495
−50.116
30.258
−10.477
1.00
36.90
C


ATOM
7560
CG
LYS
A
495
−49.235
31.524
−10.582
1.00
37.72
C


ATOM
7563
CD
LYS
A
495
−50.061
32.826
−10.585
1.00
38.87
C


ATOM
7566
CE
LYS
A
495
−49.140
34.065
−10.665
1.00
39.78
C


ATOM
7569
NZ
LYS
A
495
−49.786
35.369
−10.282
1.00
39.78
N


ATOM
7573
C
LYS
A
495
−50.238
27.809
−9.724
1.00
35.25
C


ATOM
7574
O
LYS
A
495
−50.261
27.563
−8.523
1.00
34.91
O


ATOM
7576
N
PRO
A
496
−50.978
27.107
−10.599
1.00
33.76
N


ATOM
7577
CA
PRO
A
496
−51.846
26.015
−10.162
1.00
32.74
C


ATOM
7579
CB
PRO
A
496
−52.222
25.340
−11.474
1.00
32.99
C


ATOM
7582
CG
PRO
A
496
−52.337
26.470
−12.385
1.00
33.75
C


ATOM
7585
CD
PRO
A
496
−51.196
27.400
−12.022
1.00
33.83
C


ATOM
7588
C
PRO
A
496
−51.194
24.998
−9.267
1.00
31.24
C


ATOM
7589
O
PRO
A
496
−51.822
24.522
−8.331
1.00
31.54
O


ATOM
7590
N
PHE
A
497
−49.954
24.642
−9.566
1.00
29.40
N


ATOM
7591
CA
PHE
A
497
−49.229
23.726
−8.708
1.00
27.76
C


ATOM
7593
CB
PHE
A
497
−48.162
22.948
−9.474
1.00
27.62
C


ATOM
7596
CG
PHE
A
497
−47.351
22.040
−8.597
1.00
26.33
C


ATOM
7597
CD1
PHE
A
497
−47.944
20.969
−7.974
1.00
24.96
C


ATOM
7599
CE1
PHE
A
497
−47.218
20.151
−7.156
1.00
25.04
C


ATOM
7601
CZ
PHE
A
497
−45.875
20.396
−6.940
1.00
24.79
C


ATOM
7603
CE2
PHE
A
497
−45.274
21.457
−7.549
1.00
24.73
C


ATOM
7605
CD2
PHE
A
497
−46.010
22.282
−8.366
1.00
25.48
C


ATOM
7607
C
PHE
A
497
−48.592
24.407
−7.494
1.00
26.59
C


ATOM
7608
O
PHE
A
497
−48.361
23.738
−6.500
1.00
26.77
O


ATOM
7610
N
VAL
A
498
−48.291
25.704
−7.535
1.00
24.83
N


ATOM
7611
CA
VAL
A
498
−47.869
26.338
−6.289
1.00
23.86
C


ATOM
7613
CB
VAL
A
498
−47.181
27.722
−6.455
1.00
23.47
C


ATOM
7615
CG1
VAL
A
498
−48.163
28.755
−6.759
1.00
24.57
C


ATOM
7619
CG2
VAL
A
498
−46.151
27.690
−7.551
1.00
23.54
C


ATOM
7623
C
VAL
A
498
−49.094
26.396
−5.355
1.00
22.97
C


ATOM
7624
O
VAL
A
498
−48.978
26.130
−4.161
1.00
23.39
O


ATOM
7626
N
GLU
A
499
−50.268
26.687
−5.903
1.00
21.68
N


ATOM
7627
CA
GLU
A
499
−51.473
26.719
−5.106
1.00
20.84
C


ATOM
7629
CB
GLU
A
499
−52.677
27.136
−5.930
1.00
20.99
C


ATOM
7632
CG
GLU
A
499
−53.957
27.352
−5.099
1.00
21.25
C


ATOM
7635
CD
GLU
A
499
−53.930
28.630
−4.265
1.00
21.77
C


ATOM
7636
OE1
GLU
A
499
−52.982
29.448
−4.383
1.00
20.74
O


ATOM
7637
OE2
GLU
A
499
−54.876
28.812
−3.476
1.00
22.76
O


ATOM
7638
C
GLU
A
499
−51.766
25.371
−4.497
1.00
20.35
C


ATOM
7639
O
GLU
A
499
−52.137
25.308
−3.318
1.00
20.78
O


ATOM
7641
N
THR
A
500
−51.629
24.286
−5.264
1.00
19.40
N


ATOM
7642
CA
THR
A
500
−51.894
22.970
−4.667
1.00
18.94
C


ATOM
7644
CB
THR
A
500
−51.993
21.782
−5.683
1.00
18.96
C


ATOM
7646
OG1
THR
A
500
−50.708
21.475
−6.202
1.00
19.44
O


ATOM
7648
CG2
THR
A
500
−52.991
22.071
−6.835
1.00
18.75
C


ATOM
7652
C
THR
A
500
−50.895
22.674
−3.526
1.00
18.20
C


ATOM
7653
O
THR
A
500
−51.280
22.100
−2.519
1.00
17.68
O


ATOM
7655
N
ALA
A
501
−49.646
23.119
−3.666
1.00
17.49
N


ATOM
7656
CA
ALA
A
501
−48.663
23.021
−2.593
1.00
17.18
C


ATOM
7658
CB
ALA
A
501
−47.348
23.563
−3.051
1.00
16.98
C


ATOM
7662
C
ALA
A
501
−49.120
23.770
−1.338
1.00
17.38
C


ATOM
7663
O
ALA
A
501
−49.098
23.219
−.230
1.00
17.45
O


ATOM
7665
N
ILE
A
502
−49.517
25.031
−1.508
1.00
17.29
N


ATOM
7666
CA
ILE
A
502
−49.971
25.857
−.386
1.00
17.07
C


ATOM
7668
CB
ILE
A
502
−50.353
27.304
−.846
1.00
17.09
C


ATOM
7670
CG1
ILE
A
502
−49.092
28.069
−1.286
1.00
17.17
C


ATOM
7673
CD1
ILE
A
502
−49.345
29.345
−2.116
1.00
16.25
C


ATOM
7677
CG2
ILE
A
502
−51.110
28.076
.265
1.00
16.14
C


ATOM
7681
C
ILE
A
502
−51.155
25.168
.285
1.00
17.24
C


ATOM
7682
O
ILE
A
502
−51.265
25.163
1.516
1.00
17.03
O


ATOM
7684
N
ASN
A
503
−52.022
24.559
−.522
1.00
17.32
N


ATOM
7685
CA
ASN
A
503
−53.167
23.823
.022
1.00
17.75
C


ATOM
7687
CB
ASN
A
503
−53.986
23.221
−1.121
1.00
17.70
C


ATOM
7690
CG
ASN
A
503
−54.760
24.261
−1.888
1.00
18.41
C


ATOM
7691
OD1
ASN
A
503
−55.058
25.334
−1.382
1.00
18.94
O


ATOM
7692
ND2
ASN
A
503
−55.107
23.939
−3.119
1.00
20.42
N


ATOM
7695
C
ASN
A
503
−52.803
22.727
1.075
1.00
17.74
C


ATOM
7696
O
ASN
A
503
−53.619
22.387
1.949
1.00
17.96
O


ATOM
7698
N
LEU
A
504
−51.589
22.185
.993
1.00
17.23
N


ATOM
7699
CA
LEU
A
504
−51.105
21.249
1.994
1.00
17.10
C


ATOM
7701
CB
LEU
A
504
−49.745
20.686
1.583
1.00
17.28
C


ATOM
7704
CG
LEU
A
504
−49.213
19.528
2.426
1.00
17.29
C


ATOM
7706
CD1
LEU
A
504
−49.570
18.196
1.762
1.00
17.22
C


ATOM
7710
CD2
LEU
A
504
−47.708
19.686
2.616
1.00
16.83
C


ATOM
7714
C
LEU
A
504
−50.971
21.939
3.347
1.00
16.97
C


ATOM
7715
O
LEU
A
504
−51.237
21.330
4.379
1.00
16.84
O


ATOM
7717
N
ALA
A
505
−50.535
23.201
3.330
1.00
16.90
N


ATOM
7718
CA
ALA
A
505
−50.433
24.015
4.540
1.00
16.68
C


ATOM
7720
CB
ALA
A
505
−49.739
25.309
4.243
1.00
16.54
C


ATOM
7724
C
ALA
A
505
−51.826
24.281
5.074
1.00
16.77
C


ATOM
7725
O
ALA
A
505
−52.087
24.123
6.266
1.00
16.80
O


ATOM
7727
N
ARG
A
506
−52.726
24.664
4.172
1.00
16.82
N


ATOM
7728
CA
ARG
A
506
−54.128
24.875
4.521
1.00
16.84
C


ATOM
7730
CB
ARG
A
506
−54.944
25.274
3.286
1.00
16.86
C


ATOM
7733
CG
ARG
A
506
−54.649
26.661
2.795
1.00
16.27
C


ATOM
7736
CD
ARG
A
506
−55.586
27.090
1.726
1.00
15.26
C


ATOM
7739
NE
ARG
A
506
−55.240
28.436
1.273
1.00
15.31
N


ATOM
7741
CZ
ARG
A
506
−54.744
28.758
.082
1.00
14.28
C


ATOM
7742
NH1
ARG
A
506
−54.519
27.856
−.856
1.00
14.12
N


ATOM
7745
NH2
ARG
A
506
−54.471
30.018
−.176
1.00
15.94
N


ATOM
7748
C
ARG
A
506
−54.732
23.631
5.122
1.00
16.96
C


ATOM
7749
O
ARG
A
506
−55.480
23.707
6.089
1.00
16.71
O


ATOM
7751
N
GLN
A
507
−54.415
22.481
4.542
1.00
17.37
N


ATOM
7752
CA
GLN
A
507
−54.962
21.233
5.048
1.00
17.87
C


ATOM
7754
CB
GLN
A
507
−54.712
20.075
4.087
1.00
17.80
C


ATOM
7757
CG
GLN
A
507
−55.293
18.740
4.571
1.00
17.24
C


ATOM
7760
CD
GLN
A
507
−56.777
18.805
4.860
1.00
16.23
C


ATOM
7761
OE1
GLN
A
507
−57.506
19.585
4.250
1.00
16.66
O


ATOM
7762
NE2
GLN
A
507
−57.233
17.980
5.790
1.00
14.96
N


ATOM
7765
C
GLN
A
507
−54.401
20.890
6.423
1.00
18.28
C


ATOM
7766
O
GLN
A
507
−55.148
20.419
7.287
1.00
18.53
O


ATOM
7768
N
SER
A
508
−53.096
21.113
6.609
1.00
18.50
N


ATOM
7769
CA
SER
A
508
−52.435
20.924
7.908
1.00
18.54
C


ATOM
7771
CB
SER
A
508
−50.979
21.385
7.856
1.00
18.40
C


ATOM
7774
OG
SER
A
508
−50.259
20.694
6.857
1.00
18.51
O


ATOM
7776
C
SER
A
508
−53.147
21.752
8.942
1.00
18.78
C


ATOM
7777
O
SER
A
508
−53.535
21.278
10.006
1.00
18.33
O


ATOM
7779
N
HIS
A
509
−53.324
23.014
8.599
1.00
19.37
N


ATOM
7780
CA
HIS
A
509
−54.014
23.922
9.466
1.00
19.92
C


ATOM
7782
CB
HIS
A
509
−54.126
25.295
8.818
1.00
20.07
C


ATOM
7785
CG
HIS
A
509
−53.000
26.188
9.174
1.00
19.82
C


ATOM
7786
ND1
HIS
A
509
−52.079
26.631
8.255
1.00
19.73
N


ATOM
7788
CE1
HIS
A
509
−51.187
27.383
8.866
1.00
20.25
C


ATOM
7790
NE2
HIS
A
509
−51.485
27.426
10.149
1.00
21.66
N


ATOM
7792
CD2
HIS
A
509
−52.615
26.682
10.368
1.00
20.98
C


ATOM
7794
C
HIS
A
509
−55.389
23.448
9.839
1.00
20.41
C


ATOM
7795
O
HIS
A
509
−55.821
23.694
10.934
1.00
20.22
O


ATOM
7797
N
CYS
A
510
−56.093
22.808
8.918
1.00
21.33
N


ATOM
7798
CA
CYS
A
510
−57.470
22.396
9.189
1.00
22.03
C


ATOM
7800
CB
CYS
A
510
−58.278
22.383
7.894
1.00
21.90
C


ATOM
7803
SG
CYS
A
510
−58.522
24.055
7.270
1.00
21.93
S


ATOM
7805
C
CYS
A
510
−57.527
21.054
9.908
1.00
22.60
C


ATOM
7806
O
CYS
A
510
−58.423
20.822
10.706
1.00
22.23
O


ATOM
7808
N
THR
A
511
−56.553
20.194
9.627
1.00
23.67
N


ATOM
7809
CA
THR
A
511
−56.421
18.920
10.305
1.00
24.81
C


ATOM
7811
CB
THR
A
511
−55.437
18.000
9.565
1.00
24.70
C


ATOM
7813
OG1
THR
A
511
−56.071
17.485
8.394
1.00
24.45
O


ATOM
7815
CG2
THR
A
511
−55.003
16.844
10.448
1.00
24.23
C


ATOM
7819
C
THR
A
511
−55.965
19.086
11.756
1.00
26.22
C


ATOM
7820
O
THR
A
511
−56.685
18.717
12.679
1.00
26.12
O


ATOM
7822
N
TYR
A
512
−54.775
19.643
11.959
1.00
28.08
N


ATOM
7823
CA
TYR
A
512
−54.177
19.657
13.298
1.00
29.63
C


ATOM
7825
CB
TYR
A
512
−52.663
19.783
13.238
1.00
29.67
C


ATOM
7828
CG
TYR
A
512
−52.117
18.579
12.560
1.00
29.56
C


ATOM
7829
CD1
TYR
A
512
−51.965
17.395
13.246
1.00
29.66
C


ATOM
7831
CE1
TYR
A
512
−51.507
16.273
12.614
1.00
30.94
C


ATOM
7833
CZ
TYR
A
512
−51.217
16.326
11.263
1.00
32.04
C


ATOM
7834
OH
TYR
A
512
−50.757
15.209
10.608
1.00
33.78
O


ATOM
7836
CE2
TYR
A
512
−51.390
17.492
10.557
1.00
31.29
C


ATOM
7838
CD2
TYR
A
512
−51.847
18.600
11.205
1.00
30.53
C


ATOM
7840
C
TYR
A
512
−54.812
20.676
14.206
1.00
31.11
C


ATOM
7841
O
TYR
A
512
−55.494
20.277
15.139
1.00
31.34
O


ATOM
7843
N
HIS
A
513
−54.583
21.969
13.966
1.00
32.89
N


ATOM
7844
CA
HIS
A
513
−55.505
23.023
14.442
1.00
34.48
C


ATOM
7846
CB
HIS
A
513
−56.372
23.461
13.225
1.00
35.13
C


ATOM
7849
CG
HIS
A
513
−57.704
24.108
13.529
1.00
37.10
C


ATOM
7850
ND1
HIS
A
513
−58.265
25.040
12.678
1.00
38.69
N


ATOM
7852
CE1
HIS
A
513
−59.442
25.416
13.151
1.00
39.23
C


ATOM
7854
NE2
HIS
A
513
−59.678
24.751
14.268
1.00
38.18
N


ATOM
7856
CD2
HIS
A
513
−58.615
23.915
14.519
1.00
38.17
C


ATOM
7858
C
HIS
A
513
−56.337
22.503
15.610
1.00
35.00
C


ATOM
7859
O
HIS
A
513
−56.302
23.074
16.712
1.00
35.48
O


ATOM
7861
N
ASN
A
514
−57.079
21.419
15.351
1.00
35.23
N


ATOM
7862
CA
ASN
A
514
−57.934
20.768
16.347
1.00
35.46
C


ATOM
7864
CB
ASN
A
514
−58.342
19.343
15.903
1.00
35.39
C


ATOM
7867
CG
ASN
A
514
−59.383
19.345
14.786
1.00
34.01
C


ATOM
7868
OD1
ASN
A
514
−59.336
20.185
13.896
1.00
33.36
O


ATOM
7869
ND2
ASN
A
514
−60.315
18.406
14.833
1.00
31.13
N


ATOM
7872
C
ASN
A
514
−57.464
20.751
17.818
1.00
36.15
C


ATOM
7873
O
ASN
A
514
−56.397
20.211
18.153
1.00
36.13
O


ATOM
7875
N
GLY
A
515
−58.277
21.430
18.640
1.00
36.95
N


ATOM
7876
CA
GLY
A
515
−58.427
21.235
20.079
1.00
37.43
C


ATOM
7879
C
GLY
A
515
−59.724
20.470
20.381
1.00
38.18
C


ATOM
7880
O
GLY
A
515
−59.636
19.418
21.021
1.00
38.57
O


ATOM
7882
N
ASP
A
516
−60.930
20.921
19.969
1.00
38.73
N


ATOM
7883
CA
ASP
A
516
−61.249
22.194
19.293
1.00
39.26
C


ATOM
7885
CB
ASP
A
516
−61.607
21.904
17.845
1.00
39.51
C


ATOM
7888
CG
ASP
A
516
−60.523
22.291
16.894
1.00
42.32
C


ATOM
7889
OD1
ASP
A
516
−59.613
23.084
17.286
1.00
45.56
O


ATOM
7890
OD2
ASP
A
516
−60.578
21.797
15.740
1.00
45.52
O


ATOM
7891
C
ASP
A
516
−62.466
22.913
19.884
1.00
39.38
C


ATOM
7892
O
ASP
A
516
−63.032
22.454
20.880
1.00
39.74
O


ATOM
7894
N
ALA
A
517
−62.850
24.038
19.259
1.00
39.40
N


ATOM
7895
CA
ALA
A
517
−64.140
24.752
19.481
1.00
39.50
C


ATOM
7897
CB
ALA
A
517
−65.117
24.403
18.333
1.00
39.27
C


ATOM
7901
C
ALA
A
517
−64.837
24.566
20.863
1.00
39.90
C


ATOM
7902
O
ALA
A
517
−64.173
24.428
21.899
1.00
39.89
O


ATOM
7904
N
HIS
A
518
−66.175
24.617
20.876
1.00
40.33
N


ATOM
7905
CA
HIS
A
518
−66.973
24.112
22.016
1.00
40.73
C


ATOM
7907
CB
HIS
A
518
−68.091
25.092
22.396
1.00
41.22
C


ATOM
7910
CG
HIS
A
518
−67.578
26.419
22.866
1.00
43.58
C


ATOM
7911
ND1
HIS
A
518
−67.426
26.725
24.207
1.00
45.88
N


ATOM
7913
CE1
HIS
A
518
−66.938
27.950
24.320
1.00
46.42
C


ATOM
7915
NE2
HIS
A
518
−66.760
28.446
23.102
1.00
46.25
N


ATOM
7917
CD2
HIS
A
518
−67.145
27.506
22.174
1.00
45.24
C


ATOM
7919
C
HIS
A
518
−67.526
22.725
21.655
1.00
40.17
C


ATOM
7920
O
HIS
A
518
−68.738
22.501
21.571
1.00
40.02
O


ATOM
7922
N
THR
A
519
−66.581
21.812
21.448
1.00
39.64
N


ATOM
7923
CA
THR
A
519
−66.808
20.466
20.918
1.00
39.16
C


ATOM
7925
CB
THR
A
519
−67.414
20.469
19.453
1.00
39.16
C


ATOM
7927
OG1
THR
A
519
−66.847
21.529
18.665
1.00
39.04
O


ATOM
7929
CG2
THR
A
519
−68.942
20.633
19.480
1.00
38.82
C


ATOM
7933
C
THR
A
519
−65.428
19.771
20.978
1.00
38.85
C


ATOM
7934
O
THR
A
519
−64.391
20.433
20.878
1.00
38.66
O


ATOM
7936
N
SER
A
520
−65.407
18.455
21.170
1.00
38.37
N


ATOM
7937
CA
SER
A
520
−64.160
17.745
21.500
1.00
38.08
C


ATOM
7939
CB
SER
A
520
−64.514
16.320
21.931
1.00
38.06
C


ATOM
7942
OG
SER
A
520
−64.560
15.475
20.805
1.00
38.66
O


ATOM
7944
C
SER
A
520
−63.136
17.771
20.327
1.00
37.86
C


ATOM
7945
O
SER
A
520
−63.420
18.369
19.289
1.00
37.50
O


ATOM
7947
N
PRO
A
521
−61.948
17.122
20.482
1.00
37.98
N


ATOM
7948
CA
PRO
A
521
−60.944
17.170
19.379
1.00
37.92
C


ATOM
7950
CB
PRO
A
521
−59.674
16.527
19.987
1.00
37.87
C


ATOM
7953
CG
PRO
A
521
−60.091
15.919
21.330
1.00
38.28
C


ATOM
7956
CD
PRO
A
521
−61.577
16.137
21.526
1.00
38.13
C


ATOM
7959
C
PRO
A
521
−61.432
16.446
18.110
1.00
37.96
C


ATOM
7960
O
PRO
A
521
−61.769
17.118
17.140
1.00
38.09
O


ATOM
7961
N
ASP
A
522
−61.483
15.108
18.107
1.00
38.07
N


ATOM
7962
CA
ASP
A
522
−62.351
14.393
17.161
1.00
38.14
C


ATOM
7964
CB
ASP
A
522
−62.132
12.877
17.204
1.00
38.31
C


ATOM
7967
CG
ASP
A
522
−60.769
12.456
16.640
1.00
39.45
C


ATOM
7968
OD1
ASP
A
522
−60.160
13.200
15.827
1.00
39.72
O


ATOM
7969
OD2
ASP
A
522
−60.302
11.361
17.025
1.00
41.59
O


ATOM
7970
C
ASP
A
522
−63.760
14.780
17.591
1.00
37.92
C


ATOM
7971
O
ASP
A
522
−63.908
15.608
18.474
1.00
38.01
O


ATOM
7973
N
GLU
A
523
−64.799
14.239
16.974
1.00
37.79
N


ATOM
7974
CA
GLU
A
523
−66.150
14.818
17.121
1.00
37.83
C


ATOM
7976
CB
GLU
A
523
−66.618
14.919
18.591
1.00
37.85
C


ATOM
7979
CG
GLU
A
523
−66.346
13.678
19.483
1.00
39.40
C


ATOM
7982
CD
GLU
A
523
−66.916
13.802
20.931
1.00
41.49
C


ATOM
7983
OE1
GLU
A
523
−67.714
14.737
21.207
1.00
42.81
O


ATOM
7984
OE2
GLU
A
523
−66.566
12.957
21.800
1.00
42.04
O


ATOM
7985
C
GLU
A
523
−66.242
16.203
16.430
1.00
37.51
C


ATOM
7986
O
GLU
A
523
−67.338
16.751
16.283
1.00
37.70
O


ATOM
7988
N
LEU
A
524
−65.097
16.775
16.043
1.00
37.03
N


ATOM
7989
CA
LEU
A
524
−65.044
17.863
15.067
1.00
36.58
C


ATOM
7991
CB
LEU
A
524
−64.174
19.022
15.559
1.00
36.56
C


ATOM
7994
CG
LEU
A
524
−63.963
20.225
14.624
1.00
36.35
C


ATOM
7996
CD1
LEU
A
524
−63.400
21.376
15.418
1.00
35.74
C


ATOM
8000
CD2
LEU
A
524
−65.242
20.681
13.910
1.00
36.53
C


ATOM
8004
C
LEU
A
524
−64.478
17.287
13.782
1.00
36.20
C


ATOM
8005
O
LEU
A
524
−65.106
17.363
12.733
1.00
36.14
O


ATOM
8007
N
THR
A
525
−63.298
16.686
13.869
1.00
35.83
N


ATOM
8008
CA
THR
A
525
−62.756
15.935
12.748
1.00
35.66
C


ATOM
8010
CB
THR
A
525
−61.585
15.015
13.173
1.00
35.48
C


ATOM
8012
OG1
THR
A
525
−60.776
15.678
14.152
1.00
35.55
O


ATOM
8014
CG2
THR
A
525
−60.720
14.641
11.978
1.00
34.73
C


ATOM
8018
C
THR
A
525
−63.875
15.098
12.123
1.00
35.89
C


ATOM
8019
O
THR
A
525
−64.040
15.095
10.909
1.00
35.98
O


ATOM
8021
N
ARG
A
526
−64.667
14.420
12.954
1.00
36.06
N


ATOM
8022
CA
ARG
A
526
−65.739
13.574
12.448
1.00
36.18
C


ATOM
8024
CB
ARG
A
526
−66.340
12.718
13.555
1.00
36.56
C


ATOM
8027
CG
ARG
A
526
−67.416
11.754
13.054
1.00
38.35
C


ATOM
8030
CD
ARG
A
526
−67.781
10.702
14.092
1.00
41.00
C


ATOM
8033
NE
ARG
A
526
−67.740
11.207
15.470
1.00
43.08
N


ATOM
8035
CZ
ARG
A
526
−68.637
12.033
16.024
1.00
44.51
C


ATOM
8036
NH1
ARG
A
526
−69.681
12.500
15.336
1.00
44.46
N


ATOM
8039
NH2
ARG
A
526
−68.476
12.406
17.288
1.00
45.02
N


ATOM
8042
C
ARG
A
526
−66.834
14.384
11.774
1.00
35.68
C


ATOM
8043
O
ARG
A
526
−67.253
14.035
10.675
1.00
35.84
O


ATOM
8045
N
LYS
A
527
−67.309
15.447
12.424
1.00
35.06
N


ATOM
8046
CA
LYS
A
527
−68.285
16.343
11.780
1.00
34.61
C


ATOM
8048
CB
LYS
A
527
−68.680
17.528
12.683
1.00
34.74
C


ATOM
8051
CG
LYS
A
527
−69.818
17.225
13.651
1.00
35.40
C


ATOM
8054
CD
LYS
A
527
−70.301
18.452
14.441
1.00
35.99
C


ATOM
8057
CE
LYS
A
527
−71.280
18.021
15.556
1.00
36.42
C


ATOM
8060
NZ
LYS
A
527
−71.652
19.095
16.530
1.00
36.31
N


ATOM
8064
C
LYS
A
527
−67.723
16.860
10.457
1.00
33.77
C


ATOM
8065
O
LYS
A
527
−68.377
16.763
9.423
1.00
33.75
O


ATOM
8067
N
ARG
A
528
−66.501
17.388
10.499
1.00
32.71
N


ATOM
8068
CA
ARG
A
528
−65.840
17.929
9.310
1.00
31.79
C


ATOM
8070
CB
ARG
A
528
−64.425
18.464
9.644
1.00
31.74
C


ATOM
8073
CG
ARG
A
528
−64.419
19.844
10.330
1.00
30.90
C


ATOM
8076
CD
ARG
A
528
−63.021
20.439
10.527
1.00
29.75
C


ATOM
8079
NE
ARG
A
528
−63.098
21.745
11.190
1.00
29.55
N


ATOM
8081
CZ
ARG
A
528
−62.056
22.513
11.528
1.00
29.96
C


ATOM
8082
NH1
ARG
A
528
−60.801
22.145
11.284
1.00
29.74
N


ATOM
8085
NH2
ARG
A
528
−62.269
23.677
12.130
1.00
30.71
N


ATOM
8088
C
ARG
A
528
−65.796
16.904
8.172
1.00
30.99
C


ATOM
8089
O
ARG
A
528
−66.226
17.206
7.068
1.00
30.97
O


ATOM
8091
N
VAL
A
529
−65.313
15.694
8.450
1.00
30.12
N


ATOM
8092
CA
VAL
A
529
−65.239
14.631
7.438
1.00
29.43
C


ATOM
8094
CB
VAL
A
529
−64.557
13.354
7.972
1.00
29.39
C


ATOM
8096
CG1
VAL
A
529
−64.785
12.187
7.023
1.00
28.89
C


ATOM
8100
CG2
VAL
A
529
−63.062
13.589
8.186
1.00
29.44
C


ATOM
8104
C
VAL
A
529
−66.609
14.243
6.887
1.00
28.95
C


ATOM
8105
O
VAL
A
529
−66.755
14.016
5.690
1.00
29.09
O


ATOM
8107
N
LEU
A
530
−67.615
14.153
7.744
1.00
28.18
N


ATOM
8108
CA
LEU
A
530
−68.956
13.874
7.246
1.00
27.72
C


ATOM
8110
CB
LEU
A
530
−69.971
13.715
8.395
1.00
27.75
C


ATOM
8113
CG
LEU
A
530
−70.334
12.274
8.775
1.00
27.36
C


ATOM
8115
CD1
LEU
A
530
−69.096
11.415
9.050
1.00
26.86
C


ATOM
8119
CD2
LEU
A
530
−71.273
12.279
9.968
1.00
27.14
C


ATOM
8123
C
LEU
A
530
−69.401
14.963
6.256
1.00
27.16
C


ATOM
8124
O
LEU
A
530
−69.861
14.652
5.161
1.00
27.42
O


ATOM
8126
N
SER
A
531
−69.230
16.229
6.635
1.00
26.21
N


ATOM
8127
CA
SER
A
531
−69.730
17.359
5.853
1.00
25.12
C


ATOM
8129
CB
SER
A
531
−69.519
18.657
6.618
1.00
25.01
C


ATOM
8132
OG
SER
A
531
−68.167
18.791
6.985
1.00
23.94
O


ATOM
8134
C
SER
A
531
−69.055
17.476
4.507
1.00
24.48
C


ATOM
8135
O
SER
A
531
−69.687
17.886
3.538
1.00
24.14
O


ATOM
8137
N
VAL
A
532
−67.774
17.115
4.461
1.00
23.89
N


ATOM
8138
CA
VAL
A
532
−66.962
17.226
3.246
1.00
23.53
C


ATOM
8140
CB
VAL
A
532
−65.470
17.437
3.575
1.00
23.09
C


ATOM
8142
CG1
VAL
A
532
−64.633
17.355
2.348
1.00
22.32
C


ATOM
8146
CG2
VAL
A
532
−65.268
18.773
4.198
1.00
23.07
C


ATOM
8150
C
VAL
A
532
−67.100
16.028
2.316
1.00
23.67
C


ATOM
8151
O
VAL
A
532
−67.137
16.209
1.099
1.00
23.58
O


ATOM
8153
N
ILE
A
533
−67.187
14.824
2.886
1.00
23.85
N


ATOM
8154
CA
ILE
A
533
−67.172
13.578
2.107
1.00
24.08
C


ATOM
8156
CB
ILE
A
533
−66.172
12.555
2.691
1.00
24.10
C


ATOM
8158
CG1
ILE
A
533
−64.745
13.079
2.631
1.00
23.47
C


ATOM
8161
CD1
ILE
A
533
−64.178
13.083
1.255
1.00
23.42
C


ATOM
8165
CG2
ILE
A
533
−66.254
11.231
1.932
1.00
24.56
C


ATOM
8169
C
ILE
A
533
−68.522
12.859
1.990
1.00
24.27
C


ATOM
8170
O
ILE
A
533
−68.991
12.620
.887
1.00
24.34
O


ATOM
8172
N
THR
A
534
−69.133
12.487
3.111
1.00
24.57
N


ATOM
8173
CA
THR
A
534
−70.279
11.564
3.072
1.00
24.92
C


ATOM
8175
CB
THR
A
534
−70.200
10.522
4.207
1.00
24.93
C


ATOM
8177
OG1
THR
A
534
−70.491
11.149
5.458
1.00
25.28
O


ATOM
8179
CG2
THR
A
534
−68.804
9.885
4.257
1.00
24.75
C


ATOM
8183
C
THR
A
534
−71.673
12.209
3.083
1.00
25.00
C


ATOM
8184
O
THR
A
534
−72.601
11.646
2.522
1.00
24.94
O


ATOM
8186
N
GLU
A
535
−71.821
13.374
3.708
1.00
25.26
N


ATOM
8187
CA
GLU
A
535
−73.132
14.024
3.833
1.00
25.34
C


ATOM
8189
CB
GLU
A
535
−73.333
14.523
5.255
1.00
25.44
C


ATOM
8192
CG
GLU
A
535
−73.753
13.424
6.196
1.00
25.80
C


ATOM
8195
CD
GLU
A
535
−74.307
13.963
7.468
1.00
25.72
C


ATOM
8196
OE1
GLU
A
535
−75.375
13.487
7.881
1.00
24.50
O


ATOM
8197
OE2
GLU
A
535
−73.678
14.877
8.039
1.00
27.03
O


ATOM
8198
C
GLU
A
535
−73.363
15.179
2.859
1.00
25.26
C


ATOM
8199
O
GLU
A
535
−72.686
16.206
2.939
1.00
25.02
O


ATOM
8201
N
PRO
A
536
−74.351
15.030
1.959
1.00
25.25
N


ATOM
8202
CA
PRO
A
536
−74.655
16.111
1.050
1.00
25.18
C


ATOM
8204
CB
PRO
A
536
−75.661
15.484
.076
1.00
25.15
C


ATOM
8207
CG
PRO
A
536
−75.825
14.077
.476
1.00
24.98
C


ATOM
8210
CD
PRO
A
536
−75.363
13.965
1.868
1.00
25.26
C


ATOM
8213
C
PRO
A
536
−75.289
17.265
1.801
1.00
25.30
C


ATOM
8214
O
PRO
A
536
−75.826
17.070
2.883
1.00
25.57
O


ATOM
8215
N
ILE
A
537
−75.213
18.458
1.230
1.00
25.36
N


ATOM
8216
CA
ILE
A
537
−75.807
19.638
1.827
1.00
25.34
C


ATOM
8218
CB
ILE
A
537
−75.201
20.918
1.221
1.00
25.14
C


ATOM
8220
CG1
ILE
A
537
−73.787
21.131
1.744
1.00
24.32
C


ATOM
8223
CD1
ILE
A
537
−73.228
22.472
1.406
1.00
23.22
C


ATOM
8227
CG2
ILE
A
537
−76.030
22.131
1.569
1.00
25.54
C


ATOM
8231
C
ILE
A
537
−77.313
19.603
1.611
1.00
25.67
C


ATOM
8232
O
ILE
A
537
−77.786
19.132
.579
1.00
25.47
O


ATOM
8234
N
LEU
A
538
−78.071
20.088
2.586
1.00
26.22
N


ATOM
8235
CA
LEU
A
538
−79.514
20.051
2.467
1.00
26.65
C


ATOM
8237
CB
LEU
A
538
−80.213
20.525
3.749
1.00
26.78
C


ATOM
8240
CG
LEU
A
538
−80.162
19.609
4.989
1.00
26.64
C


ATOM
8242
CD1
LEU
A
538
−81.218
20.033
6.007
1.00
26.16
C


ATOM
8246
CD2
LEU
A
538
−80.346
18.138
4.633
1.00
26.12
C


ATOM
8250
C
LEU
A
538
−79.925
20.881
1.262
1.00
27.08
C


ATOM
8253
N
PRO
A
539
−80.786
20.306
.414
1.00
28.03
N


ATOM
8254
CA
PRO
A
539
−81.117
20.855
−.888
1.00
28.44
C


ATOM
8256
CB
PRO
A
539
−82.093
19.828
−1.449
1.00
28.40
C


ATOM
8259
CG
PRO
A
539
−82.793
19.328
−.253
1.00
28.30
C


ATOM
8262
CD
PRO
A
539
−81.720
19.228
.787
1.00
28.11
C


ATOM
8265
C
PRO
A
539
−81.813
22.194
−.804
1.00
28.89
C


ATOM
8266
O
PRO
A
539
−82.396
22.535
.226
1.00
28.97
O


ATOM
8267
N
PHE
A
540
−81.774
22.932
−1.906
1.00
29.32
N


ATOM
8268
CA
PHE
A
540
−82.380
24.245
−1.962
1.00
29.50
C


ATOM
8270
CB
PHE
A
540
−82.146
24.874
−3.326
1.00
29.56
C


ATOM
8273
CG
PHE
A
540
−82.757
26.227
−3.463
1.00
29.75
C


ATOM
8274
CD1
PHE
A
540
−83.874
26.429
−4.255
1.00
29.47
C


ATOM
8276
CE1
PHE
A
540
−84.441
27.681
−4.364
1.00
29.46
C


ATOM
8278
CZ
PHE
A
540
−83.901
28.743
−3.674
1.00
29.81
C


ATOM
8280
CE2
PHE
A
540
−82.791
28.553
−2.877
1.00
30.21
C


ATOM
8282
CD2
PHE
A
540
−82.229
27.300
−2.770
1.00
30.17
C


ATOM
8284
C
PHE
A
540
−83.865
24.129
−1.722
1.00
29.66
C


ATOM
8285
O
PHE
A
540
−84.568
23.551
−2.545
1.00
29.66
O


ATOM
8287
N
GLU
A
541
−84.337
24.673
−.601
1.00
29.90
N


ATOM
8288
CA
GLU
A
541
−85.761
24.605
−.233
1.00
30.06
C


ATOM
8290
CB
GLU
A
541
−85.951
23.724
1.017
1.00
30.15
C


ATOM
8293
CG
GLU
A
541
−87.411
23.361
1.367
1.00
30.64
C


ATOM
8296
CD
GLU
A
541
−88.091
24.351
2.322
1.00
31.35
C


ATOM
8297
OE1
GLU
A
541
−87.468
25.370
2.680
1.00
32.67
O


ATOM
8298
OE2
GLU
A
541
−89.254
24.114
2.719
1.00
30.48
O


ATOM
8299
C
GLU
A
541
−86.315
26.011
−.010
1.00
29.89
C


ATOM
8300
O
GLU
A
541
−86.835
26.636
−.936
1.00
29.71
O


ATOM
8302
N
LEU
B
17
−69.666
−25.325
2.227
1.00
33.20
N


ATOM
8303
CA
LEU
B
17
−69.356
−25.417
.755
1.00
33.49
C


ATOM
8305
CB
LEU
B
17
−70.240
−26.475
.048
1.00
33.44
C


ATOM
8308
CG
LEU
B
17
−70.077
−27.986
.328
1.00
33.60
C


ATOM
8310
CD1
LEU
B
17
−71.285
−28.778
−.217
1.00
32.76
C


ATOM
8314
CD2
LEU
B
17
−68.763
−28.553
−.230
1.00
33.21
C


ATOM
8318
C
LEU
B
17
−69.513
−24.044
.055
1.00
33.54
C


ATOM
8319
O
LEU
B
17
−70.550
−23.380
.195
1.00
33.77
O


ATOM
8323
N
LEU
B
18
−68.481
−23.637
−.696
1.00
33.44
N


ATOM
8324
CA
LEU
B
18
−68.476
−22.362
−1.454
1.00
33.07
C


ATOM
8326
CB
LEU
B
18
−67.029
−21.960
−1.840
1.00
33.21
C


ATOM
8329
CG
LEU
B
18
−66.065
−21.488
−.721
1.00
34.06
C


ATOM
8331
CD1
LEU
B
18
−64.607
−21.351
−1.235
1.00
34.51
C


ATOM
8335
CD2
LEU
B
18
−66.516
−20.164
−.061
1.00
33.43
C


ATOM
8339
C
LEU
B
18
−69.379
−22.400
−2.714
1.00
32.37
C


ATOM
8340
O
LEU
B
18
−69.710
−21.355
−3.274
1.00
32.29
O


ATOM
8342
N
SER
B
19
−69.765
−23.597
−3.153
1.00
31.62
N


ATOM
8343
CA
SER
B
19
−70.711
−23.749
−4.253
1.00
31.16
C


ATOM
8345
CB
SER
B
19
−70.443
−25.067
−5.033
1.00
31.09
C


ATOM
8348
OG
SER
B
19
−70.977
−26.243
−4.421
1.00
29.36
O


ATOM
8350
C
SER
B
19
−72.168
−23.663
−3.759
1.00
31.45
C


ATOM
8351
O
SER
B
19
−73.076
−23.432
−4.551
1.00
31.13
O


ATOM
8353
N
SER
B
20
−72.386
−23.824
−2.451
1.00
31.91
N


ATOM
8354
CA
SER
B
20
−73.749
−23.900
−1.879
1.00
32.34
C


ATOM
8356
CB
SER
B
20
−73.706
−24.122
−.357
1.00
32.35
C


ATOM
8359
OG
SER
B
20
−73.393
−25.473
−.055
1.00
32.34
O


ATOM
8361
C
SER
B
20
−74.601
−22.670
−2.204
1.00
32.69
C


ATOM
8362
O
SER
B
20
−74.072
−21.600
−2.487
1.00
32.89
O


ATOM
8364
N
ASP
B
21
−75.921
−22.831
−2.119
1.00
33.13
N


ATOM
8365
CA
ASP
B
21
−76.874
−21.901
−2.745
1.00
33.40
C


ATOM
8367
CB
ASP
B
21
−78.179
−22.628
−3.045
1.00
33.64
C


ATOM
8370
CG
ASP
B
21
−77.943
−23.883
−3.828
1.00
35.35
C


ATOM
8371
OD1
ASP
B
21
−77.031
−23.866
−4.684
1.00
38.26
O


ATOM
8372
OD2
ASP
B
21
−78.631
−24.890
−3.590
1.00
37.55
O


ATOM
8373
C
ASP
B
21
−77.141
−20.649
−1.940
1.00
33.23
C


ATOM
8374
O
ASP
B
21
−78.039
−20.616
−1.106
1.00
32.91
O


ATOM
8376
N
THR
B
22
−76.348
−19.621
−2.229
1.00
33.46
N


ATOM
8377
CA
THR
B
22
−76.443
−18.307
−1.593
1.00
33.79
C


ATOM
8379
CB
THR
B
22
−76.460
−18.378
−.016
1.00
33.74
C


ATOM
8381
OG1
THR
B
22
−75.426
−19.250
.460
1.00
32.97
O


ATOM
8383
CG2
THR
B
22
−77.805
−18.838
.535
1.00
33.55
C


ATOM
8387
C
THR
B
22
−75.217
−17.479
−2.018
1.00
34.24
C


ATOM
8388
O
THR
B
22
−74.102
−17.988
−1.892
1.00
33.95
O


ATOM
8390
N
ASP
B
23
−75.361
−16.248
−2.543
1.00
34.99
N


ATOM
8391
CA
ASP
B
23
−76.603
−15.620
−3.103
1.00
35.61
C


ATOM
8393
CB
ASP
B
23
−77.242
−16.538
−4.170
1.00
35.51
C


ATOM
8396
CG
ASP
B
23
−76.196
−17.236
−5.034
1.00
36.08
C


ATOM
8397
OD1
ASP
B
23
−75.084
−16.685
−5.194
1.00
35.58
O


ATOM
8398
OD2
ASP
B
23
−76.473
−18.344
−5.541
1.00
37.65
O


ATOM
8399
C
ASP
B
23
−77.662
−15.083
−2.097
1.00
36.10
C


ATOM
8400
O
ASP
B
23
−78.644
−15.770
−1.799
1.00
36.13
O


ATOM
8402
N
GLU
B
24
−77.487
−13.845
−1.616
1.00
36.74
N


ATOM
8403
CA
GLU
B
24
−78.358
−13.316
−.543
1.00
37.59
C


ATOM
8405
CB
GLU
B
24
−77.765
−13.666
.838
1.00
37.88
C


ATOM
8408
CG
GLU
B
24
−77.624
−15.173
1.120
1.00
38.51
C


ATOM
8411
CD
GLU
B
24
−77.314
−15.510
2.588
1.00
39.48
C


ATOM
8412
OE1
GLU
B
24
−77.171
−14.581
3.434
1.00
39.60
O


ATOM
8413
OE2
GLU
B
24
−77.221
−16.725
2.884
1.00
39.51
O


ATOM
8414
C
GLU
B
24
−78.730
−11.809
−.559
1.00
38.11
C


ATOM
8415
O
GLU
B
24
−79.840
−11.453
−.972
1.00
38.20
O


ATOM
8417
N
SER
B
25
−77.825
−10.941
−.089
1.00
38.70
N


ATOM
8418
CA
SER
B
25
−78.192
−9.560
.312
1.00
39.21
C


ATOM
8420
CB
SER
B
25
−76.995
−8.783
.916
1.00
39.29
C


ATOM
8423
OG
SER
B
25
−76.267
−8.037
−.056
1.00
39.40
O


ATOM
8425
C
SER
B
25
−78.853
−8.738
−.802
1.00
39.69
C


ATOM
8426
O
SER
B
25
−78.707
−9.050
−1.995
1.00
39.75
O


ATOM
8428
N
ILE
B
26
−79.544
−7.670
−.378
1.00
40.21
N


ATOM
8429
CA
ILE
B
26
−80.554
−6.962
−1.189
1.00
40.55
C


ATOM
8431
CB
ILE
B
26
−79.925
−6.082
−2.319
1.00
40.66
C


ATOM
8433
CG1
ILE
B
26
−79.083
−4.951
−1.700
1.00
40.73
C


ATOM
8436
CD1
ILE
B
26
−78.596
−3.877
−2.698
1.00
40.68
C


ATOM
8440
CG2
ILE
B
26
−81.018
−5.475
−3.203
1.00
40.88
C


ATOM
8444
C
ILE
B
26
−81.575
−7.999
−1.714
1.00
40.72
C


ATOM
8445
O
ILE
B
26
−81.311
−8.710
−2.690
1.00
40.80
O


ATOM
8447
N
GLU
B
27
−82.729
−8.070
−1.037
1.00
40.86
N


ATOM
8448
CA
GLU
B
27
−83.694
−9.190
−1.160
1.00
40.88
C


ATOM
8450
CB
GLU
B
27
−84.782
−9.060
−.061
1.00
40.95
C


ATOM
8453
CG
GLU
B
27
−84.235
−9.257
1.379
1.00
41.28
C


ATOM
8456
CD
GLU
B
27
−85.123
−8.657
2.484
1.00
41.74
C


ATOM
8457
OE1
GLU
B
27
−85.593
−7.504
2.344
1.00
41.14
O


ATOM
8458
OE2
GLU
B
27
−85.332
−9.337
3.514
1.00
42.36
O


ATOM
8459
C
GLU
B
27
−84.290
−9.355
−2.587
1.00
40.75
C


ATOM
8460
O
GLU
B
27
−83.664
−8.936
−3.569
1.00
40.88
O


ATOM
8462
N
VAL
B
28
−85.461
−9.994
−2.712
1.00
40.40
N


ATOM
8463
CA
VAL
B
28
−86.033
−10.361
−4.027
1.00
39.97
C


ATOM
8465
CB
VAL
B
28
−86.034
−9.157
−5.053
1.00
40.03
C


ATOM
8467
CG1
VAL
B
28
−86.494
−9.600
−6.444
1.00
39.63
C


ATOM
8471
CG2
VAL
B
28
−86.900
−7.994
−4.525
1.00
39.86
C


ATOM
8475
C
VAL
B
28
−85.335
−11.600
−4.625
1.00
39.63
C


ATOM
8476
O
VAL
B
28
−85.858
−12.204
−5.567
1.00
39.63
O


ATOM
8478
N
HIS
B
29
−84.175
−11.980
−4.069
1.00
39.21
N


ATOM
8479
CA
HIS
B
29
−83.431
−13.177
−4.504
1.00
38.81
C


ATOM
8481
CB
HIS
B
29
−81.914
−12.913
−4.665
1.00
38.97
C


ATOM
8484
CG
HIS
B
29
−81.571
−11.721
−5.512
1.00
39.99
C


ATOM
8485
ND1
HIS
B
29
−81.181
−11.825
−6.834
1.00
40.79
N


ATOM
8487
CE1
HIS
B
29
−80.931
−10.615
−7.312
1.00
40.76
C


ATOM
8489
NE2
HIS
B
29
−81.134
−9.734
−6.346
1.00
40.27
N


ATOM
8491
CD2
HIS
B
29
−81.525
−10.400
−5.209
1.00
40.17
C


ATOM
8493
C
HIS
B
29
−83.611
−14.340
−3.523
1.00
38.05
C


ATOM
8494
O
HIS
B
29
−82.782
−15.259
−3.526
1.00
38.02
O


ATOM
8496
N
LYS
B
30
−84.667
−14.321
−2.694
1.00
37.06
N


ATOM
8497
CA
LYS
B
30
−85.107
−15.559
−2.022
1.00
36.33
C


ATOM
8499
CB
LYS
B
30
−86.056
−15.286
−.836
1.00
36.27
C


ATOM
8502
CG
LYS
B
30
−85.352
−14.818
.461
1.00
36.09
C


ATOM
8505
CD
LYS
B
30
−86.355
−14.599
1.612
1.00
36.03
C


ATOM
8508
CE
LYS
B
30
−85.811
−13.659
2.701
1.00
36.24
C


ATOM
8511
NZ
LYS
B
30
−86.802
−13.356
3.789
1.00
35.65
N


ATOM
8515
C
LYS
B
30
−85.710
−16.510
−3.094
1.00
35.69
C


ATOM
8516
O
LYS
B
30
−86.706
−17.205
−2.879
1.00
35.35
O


ATOM
8518
N
ASP
B
31
−85.075
−16.484
−4.268
1.00
35.13
N


ATOM
8519
CA
ASP
B
31
−85.145
−17.519
−5.282
1.00
34.64
C


ATOM
8521
CB
ASP
B
31
−84.592
−16.962
−6.623
1.00
34.60
C


ATOM
8524
CG
ASP
B
31
−84.419
−18.032
−7.725
1.00
34.24
C


ATOM
8525
OD1
ASP
B
31
−84.914
−19.165
−7.570
1.00
34.58
O


ATOM
8526
OD2
ASP
B
31
−83.776
−17.732
−8.761
1.00
31.56
O


ATOM
8527
C
ASP
B
31
−84.304
−18.675
−4.721
1.00
34.31
C


ATOM
8528
O
ASP
B
31
−83.122
−18.838
−5.038
1.00
34.03
O


ATOM
8530
N
LYS
B
32
−84.917
−19.429
−3.813
1.00
33.94
N


ATOM
8531
CA
LYS
B
32
−84.380
−20.710
−3.369
1.00
33.36
C


ATOM
8533
CB
LYS
B
32
−83.772
−20.607
−1.973
1.00
33.45
C


ATOM
8536
CG
LYS
B
32
−82.540
−19.693
−1.951
1.00
33.56
C


ATOM
8539
CD
LYS
B
32
−82.025
−19.455
−.532
1.00
34.17
C


ATOM
8542
CE
LYS
B
32
−81.671
−17.987
−.283
1.00
34.16
C


ATOM
8545
NZ
LYS
B
32
−80.746
−17.437
−1.311
1.00
34.07
N


ATOM
8549
C
LYS
B
32
−85.490
−21.764
−3.499
1.00
32.57
C


ATOM
8550
O
LYS
B
32
−85.908
−22.412
−2.538
1.00
32.10
O


ATOM
8552
N
ALA
B
33
−85.976
−21.859
−4.738
1.00
31.66
N


ATOM
8553
CA
ALA
B
33
−86.576
−23.055
−5.259
1.00
30.94
C


ATOM
8555
CB
ALA
B
33
−87.247
−22.773
−6.597
1.00
30.47
C


ATOM
8559
C
ALA
B
33
−85.442
−24.081
−5.403
1.00
30.55
C


ATOM
8560
O
ALA
B
33
−85.684
−25.230
−5.751
1.00
31.12
O


ATOM
8562
N
LYS
B
34
−84.200
−23.660
−5.161
1.00
29.73
N


ATOM
8563
CA
LYS
B
34
−83.107
−24.585
−4.839
1.00
29.09
C


ATOM
8565
CB
LYS
B
34
−81.776
−23.817
−4.865
1.00
29.30
C


ATOM
8568
CG
LYS
B
34
−80.678
−24.474
−5.726
1.00
29.76
C


ATOM
8571
CD
LYS
B
34
−79.633
−23.458
−6.283
1.00
28.74
C


ATOM
8574
CE
LYS
B
34
−78.417
−24.186
−6.890
1.00
27.56
C


ATOM
8577
NZ
LYS
B
34
−78.745
−25.174
−7.935
1.00
26.16
N


ATOM
8581
C
LYS
B
34
−83.376
−25.320
−3.472
1.00
28.37
C


ATOM
8582
O
LYS
B
34
−83.254
−24.755
−2.374
1.00
27.82
O


ATOM
8584
N
LYS
B
35
−83.635
−26.620
−3.604
1.00
27.53
N


ATOM
8585
CA
LYS
B
35
−84.629
−27.429
−2.851
1.00
26.77
C


ATOM
8587
CB
LYS
B
35
−85.729
−26.602
−2.170
1.00
26.81
C


ATOM
8590
CG
LYS
B
35
−87.089
−26.520
−2.907
1.00
27.05
C


ATOM
8593
CD
LYS
B
35
−88.096
−27.604
−2.452
1.00
27.41
C


ATOM
8596
CE
LYS
B
35
−89.394
−27.636
−3.300
1.00
27.21
C


ATOM
8599
NZ
LYS
B
35
−90.501
−26.792
−2.762
1.00
26.28
N


ATOM
8603
C
LYS
B
35
−85.257
−28.357
−3.920
1.00
26.03
C


ATOM
8604
O
LYS
B
35
−85.853
−29.386
−3.626
1.00
26.00
O


ATOM
8606
N
LEU
B
36
−85.171
−27.909
−5.168
1.00
24.98
N


ATOM
8607
CA
LEU
B
36
−85.095
−28.783
−6.319
1.00
24.02
C


ATOM
8609
CB
LEU
B
36
−85.004
−27.930
−7.594
1.00
23.83
C


ATOM
8612
CG
LEU
B
36
−86.208
−27.103
−8.062
1.00
22.23
C


ATOM
8614
CD1
LEU
B
36
−85.762
−25.873
−8.802
1.00
19.93
C


ATOM
8618
CD2
LEU
B
36
−87.092
−27.930
−8.951
1.00
22.11
C


ATOM
8622
C
LEU
B
36
−83.834
−29.659
−6.185
1.00
23.58
C


ATOM
8623
O
LEU
B
36
−83.840
−30.842
−6.508
1.00
23.38
O


ATOM
8625
N
GLU
B
37
−82.742
−29.046
−5.739
1.00
23.18
N


ATOM
8626
CA
GLU
B
37
−81.510
−29.753
−5.396
1.00
22.88
C


ATOM
8628
CB
GLU
B
37
−80.466
−28.766
−4.855
1.00
22.76
C


ATOM
8631
CG
GLU
B
37
−79.038
−29.297
−4.874
1.00
22.24
C


ATOM
8634
CD
GLU
B
37
−78.085
−28.505
−4.009
1.00
21.06
C


ATOM
8635
OE1
GLU
B
37
−78.368
−27.331
−3.737
1.00
19.65
O


ATOM
8636
OE2
GLU
B
37
−77.037
−29.059
−3.615
1.00
20.62
O


ATOM
8637
C
GLU
B
37
−81.748
−30.856
−4.364
1.00
22.95
C


ATOM
8638
O
GLU
B
37
−81.164
−31.933
−4.458
1.00
22.99
O


ATOM
8640
N
ALA
B
38
−82.591
−30.575
−3.372
1.00
23.02
N


ATOM
8641
CA
ALA
B
38
−82.973
−31.565
−2.364
1.00
22.93
C


ATOM
8643
CB
ALA
B
38
−83.966
−30.959
−1.374
1.00
22.73
C


ATOM
8647
C
ALA
B
38
−83.580
−32.778
−3.044
1.00
23.05
C


ATOM
8648
O
ALA
B
38
−83.170
−33.909
−2.813
1.00
22.52
O


ATOM
8650
N
GLU
B
39
−84.546
−32.506
−3.912
1.00
23.66
N


ATOM
8651
CA
GLU
B
39
−85.273
−33.534
−4.642
1.00
24.08
C


ATOM
8653
CB
GLU
B
39
−86.403
−32.891
−5.453
1.00
24.28
C


ATOM
8656
CG
GLU
B
39
−87.405
−33.869
−6.075
1.00
25.14
C


ATOM
8659
CD
GLU
B
39
−88.773
−33.227
−6.341
1.00
26.43
C


ATOM
8660
OE1
GLU
B
39
−89.232
−32.381
−5.519
1.00
25.90
O


ATOM
8661
OE2
GLU
B
39
−89.387
−33.584
−7.375
1.00
26.99
O


ATOM
8662
C
GLU
B
39
−84.362
−34.359
−5.545
1.00
24.18
C


ATOM
8663
O
GLU
B
39
−84.483
−35.579
−5.575
1.00
24.32
O


ATOM
8665
N
VAL
B
40
−83.450
−33.710
−6.269
1.00
24.43
N


ATOM
8666
CA
VAL
B
40
−82.533
−34.437
−7.153
1.00
24.59
C


ATOM
8668
CB
VAL
B
40
−81.734
−33.496
−8.087
1.00
24.65
C


ATOM
8670
CG1
VAL
B
40
−80.611
−34.258
−8.792
1.00
24.14
C


ATOM
8674
CG2
VAL
B
40
−82.662
−32.852
−9.106
1.00
23.89
C


ATOM
8678
C
VAL
B
40
−81.592
−35.304
−6.328
1.00
24.99
C


ATOM
8679
O
VAL
B
40
−81.265
−36.407
−6.717
1.00
24.77
O


ATOM
8681
N
ARG
B
41
−81.184
−34.811
−5.171
1.00
25.79
N


ATOM
8682
CA
ARG
B
41
−80.387
−35.613
−4.248
1.00
26.75
C


ATOM
8684
CB
ARG
B
41
−80.032
−34.823
−2.998
1.00
27.38
C


ATOM
8687
CG
ARG
B
41
−78.568
−34.777
−2.757
1.00
30.18
C


ATOM
8690
CD
ARG
B
41
−78.281
−34.610
−1.273
1.00
34.43
C


ATOM
8693
NE
ARG
B
41
−76.896
−34.198
−1.016
1.00
37.07
N


ATOM
8695
CZ
ARG
B
41
−76.350
−33.045
−1.416
1.00
38.54
C


ATOM
8696
NH1
ARG
B
41
−75.083
−32.797
−1.112
1.00
40.04
N


ATOM
8699
NH2
ARG
B
41
−77.037
−32.145
−2.128
1.00
38.45
N


ATOM
8702
C
ARG
B
41
−81.081
−36.860
−3.762
1.00
26.60
C


ATOM
8703
O
ARG
B
41
−80.446
−37.894
−3.627
1.00
26.89
O


ATOM
8705
N
ARG
B
42
−82.363
−36.733
−3.423
1.00
26.41
N


ATOM
8706
CA
ARG
B
42
−83.159
−37.870
−3.002
1.00
26.09
C


ATOM
8708
CB
ARG
B
42
−84.588
−37.452
−2.674
1.00
25.99
C


ATOM
8711
CG
ARG
B
42
−85.426
−38.562
−2.049
1.00
25.45
C


ATOM
8714
CD
ARG
B
42
−86.783
−38.078
−1.645
1.00
24.26
C


ATOM
8717
NE
ARG
B
42
−87.549
−37.602
−2.794
1.00
23.73
N


ATOM
8719
CZ
ARG
B
42
−88.547
−36.722
−2.717
1.00
24.51
C


ATOM
8720
NH1
ARG
B
42
−88.912
−36.195
−1.545
1.00
24.99
N


ATOM
8723
NH2
ARG
B
42
−89.185
−36.354
−3.816
1.00
24.46
N


ATOM
8726
C
ARG
B
42
−83.167
−38.894
−4.118
1.00
26.28
C


ATOM
8727
O
ARG
B
42
−82.864
−40.054
−3.888
1.00
26.39
O


ATOM
8729
N
GLU
B
43
−83.476
−38.460
−5.334
1.00
26.52
N


ATOM
8730
CA
GLU
B
43
−83.476
−39.370
−6.479
1.00
27.00
C


ATOM
8732
CB
GLU
B
43
−83.982
−38.676
−7.753
1.00
27.50
C


ATOM
8735
CG
GLU
B
43
−85.469
−38.275
−7.699
1.00
29.78
C


ATOM
8738
CD
GLU
B
43
−86.342
−39.301
−6.974
1.00
32.52
C


ATOM
8739
OE1
GLU
B
43
−86.388
−40.455
−7.445
1.00
35.06
O


ATOM
8740
OE2
GLU
B
43
−86.966
−38.963
−5.936
1.00
33.80
O


ATOM
8741
C
GLU
B
43
−82.147
−40.059
−6.769
1.00
26.37
C


ATOM
8742
O
GLU
B
43
−82.162
−41.126
−7.355
1.00
26.63
O


ATOM
8744
N
ILE
B
44
−81.018
−39.472
−6.373
1.00
25.85
N


ATOM
8745
CA
ILE
B
44
−79.717
−40.126
−6.555
1.00
25.55
C


ATOM
8747
CB
ILE
B
44
−78.547
−39.121
−6.692
1.00
25.26
C


ATOM
8749
CG1
ILE
B
44
−78.706
−38.273
−7.953
1.00
24.47
C


ATOM
8752
CD1
ILE
B
44
−77.690
−37.163
−8.114
1.00
23.21
C


ATOM
8756
CG2
ILE
B
44
−77.207
−39.863
−6.778
1.00
25.35
C


ATOM
8760
C
ILE
B
44
−79.404
−41.109
−5.428
1.00
25.84
C


ATOM
8761
O
ILE
B
44
−78.925
−42.208
−5.698
1.00
25.97
O


ATOM
8763
N
ASN
B
45
−79.663
−40.708
−4.177
1.00
26.25
N


ATOM
8764
CA
ASN
B
45
−79.403
−41.542
−2.983
1.00
26.34
C


ATOM
8766
CB
ASN
B
45
−79.284
−40.681
−1.719
1.00
26.01
C


ATOM
8769
CG
ASN
B
45
−78.072
−39.789
−1.723
1.00
24.65
C


ATOM
8770
OD1
ASN
B
45
−76.957
−40.226
−1.434
1.00
22.47
O


ATOM
8771
ND2
ASN
B
45
−78.288
−38.516
−2.009
1.00
23.36
N


ATOM
8774
C
ASN
B
45
−80.488
−42.586
−2.731
1.00
27.18
C


ATOM
8775
O
ASN
B
45
−80.374
−43.390
−1.806
1.00
27.30
O


ATOM
8777
N
ASN
B
46
−81.553
−42.541
−3.527
1.00
28.17
N


ATOM
8778
CA
ASN
B
46
−82.619
−43.536
−3.489
1.00
29.02
C


ATOM
8780
CB
ASN
B
46
−83.558
−43.289
−4.665
1.00
29.05
C


ATOM
8783
CG
ASN
B
46
−84.615
−44.345
−4.806
1.00
28.82
C


ATOM
8784
OD1
ASN
B
46
−84.861
−45.132
−3.895
1.00
28.14
O


ATOM
8785
ND2
ASN
B
46
−85.255
−44.369
−5.968
1.00
29.67
N


ATOM
8788
C
ASN
B
46
−82.076
−44.958
−3.549
1.00
30.14
C


ATOM
8789
O
ASN
B
46
−81.566
−45.408
−4.581
1.00
30.30
O


ATOM
8791
N
GLU
B
47
−82.218
−45.674
−2.446
1.00
31.36
N


ATOM
8792
CA
GLU
B
47
−81.575
−46.968
−2.295
1.00
32.61
C


ATOM
8794
CB
GLU
B
47
−81.617
−47.430
−.823
1.00
33.09
C


ATOM
8797
CG
GLU
B
47
−80.974
−46.466
.218
1.00
34.19
C


ATOM
8800
CD
GLU
B
47
−81.919
−45.337
.721
1.00
34.57
C


ATOM
8801
OE1
GLU
B
47
−82.911
−45.012
.029
1.00
34.53
O


ATOM
8802
OE2
GLU
B
47
−81.652
−44.762
1.805
1.00
34.30
O


ATOM
8803
C
GLU
B
47
−82.205
−48.046
−3.172
1.00
33.18
C


ATOM
8804
O
GLU
B
47
−81.604
−49.088
−3.370
1.00
33.44
O


ATOM
8806
N
LYS
B
48
−83.408
−47.808
−3.692
1.00
34.11
N


ATOM
8807
CA
LYS
B
48
−84.164
−48.853
−4.396
1.00
34.85
C


ATOM
8809
CB
LYS
B
48
−85.379
−49.254
−3.542
1.00
35.09
C


ATOM
8812
CG
LYS
B
48
−85.003
−49.723
−2.127
1.00
36.00
C


ATOM
8815
CD
LYS
B
48
−86.174
−50.338
−1.350
1.00
37.13
C


ATOM
8818
CE
LYS
B
48
−87.312
−49.340
−1.094
1.00
37.90
C


ATOM
8821
NZ
LYS
B
48
−86.908
−48.161
−.272
1.00
38.31
N


ATOM
8825
C
LYS
B
48
−84.586
−48.487
−5.835
1.00
35.13
C


ATOM
8826
O
LYS
B
48
−85.544
−49.030
−6.361
1.00
34.60
O


ATOM
8828
N
ALA
B
49
−83.858
−47.576
−6.474
1.00
36.09
N


ATOM
8829
CA
ALA
B
49
−84.093
−47.261
−7.886
1.00
36.87
C


ATOM
8831
CB
ALA
B
49
−83.550
−45.880
−8.238
1.00
36.73
C


ATOM
8835
C
ALA
B
49
−83.406
−48.325
−8.714
1.00
37.56
C


ATOM
8836
O
ALA
B
49
−82.315
−48.761
−8.363
1.00
37.62
O


ATOM
8838
N
GLU
B
50
−84.028
−48.754
−9.807
1.00
38.54
N


ATOM
8839
CA
GLU
B
50
−83.399
−49.772
−10.652
1.00
39.40
C


ATOM
8841
CB
GLU
B
50
−84.380
−50.384
−11.673
1.00
39.71
C


ATOM
8844
CG
GLU
B
50
−83.959
−51.808
−12.179
1.00
41.33
C


ATOM
8847
CD
GLU
B
50
−83.733
−52.860
−11.039
1.00
42.88
C


ATOM
8848
OE1
GLU
B
50
−84.683
−53.628
−10.718
1.00
42.94
O


ATOM
8849
OE2
GLU
B
50
−82.603
−52.921
−10.472
1.00
42.96
O


ATOM
8850
C
GLU
B
50
−82.171
−49.163
−11.330
1.00
39.43
C


ATOM
8851
O
GLU
B
50
−82.211
−48.017
−11.791
1.00
39.66
O


ATOM
8853
N
PHE
B
51
−81.084
−49.929
−11.376
1.00
39.32
N


ATOM
8854
CA
PHE
B
51
−79.763
−49.360
−11.636
1.00
39.32
C


ATOM
8856
CB
PHE
B
51
−78.675
−50.429
−11.476
1.00
39.62
C


ATOM
8859
CG
PHE
B
51
−78.470
−50.889
−10.032
1.00
41.82
C


ATOM
8860
CD1
PHE
B
51
−78.093
−49.978
−9.032
1.00
42.93
C


ATOM
8862
CE1
PHE
B
51
−77.892
−50.391
−7.705
1.00
43.30
C


ATOM
8864
CZ
PHE
B
51
−78.059
−51.729
−7.359
1.00
44.33
C


ATOM
8866
CE2
PHE
B
51
−78.430
−52.659
−8.341
1.00
44.75
C


ATOM
8868
CD2
PHE
B
51
−78.633
−52.234
−9.677
1.00
44.06
C


ATOM
8870
C
PHE
B
51
−79.646
−48.625
−12.976
1.00
38.57
C


ATOM
8871
O
PHE
B
51
−79.045
−47.564
−13.046
1.00
38.50
O


ATOM
8873
N
LEU
B
52
−80.262
−49.155
−14.024
1.00
37.99
N


ATOM
8874
CA
LEU
B
52
−80.176
−48.539
−15.351
1.00
37.42
C


ATOM
8876
CB
LEU
B
52
−80.774
−49.476
−16.399
1.00
37.66
C


ATOM
8879
CG
LEU
B
52
−80.502
−49.168
−17.876
1.00
38.39
C


ATOM
8881
CD1
LEU
B
52
−80.171
−50.452
−18.652
1.00
38.46
C


ATOM
8885
CD2
LEU
B
52
−81.703
−48.432
−18.500
1.00
39.23
C


ATOM
8889
C
LEU
B
52
−80.824
−47.143
−15.431
1.00
36.69
C


ATOM
8890
O
LEU
B
52
−80.383
−46.312
−16.224
1.00
36.59
O


ATOM
8892
N
THR
B
53
−81.859
−46.879
−14.625
1.00
35.87
N


ATOM
8893
CA
THR
B
53
−82.409
−45.510
−14.513
1.00
34.91
C


ATOM
8895
CB
THR
B
53
−83.784
−45.421
−13.805
1.00
34.72
C


ATOM
8897
OG1
THR
B
53
−84.724
−46.269
−14.455
1.00
34.04
O


ATOM
8899
CG2
THR
B
53
−84.316
−43.981
−13.855
1.00
34.81
C


ATOM
8903
C
THR
B
53
−81.454
−44.642
−13.722
1.00
34.05
C


ATOM
8904
O
THR
B
53
−81.170
−43.513
−14.121
1.00
34.16
O


ATOM
8906
N
LEU
B
54
−80.987
−45.167
−12.593
1.00
32.84
N


ATOM
8907
CA
LEU
B
54
−80.027
−44.461
−11.772
1.00
32.16
C


ATOM
8909
CB
LEU
B
54
−79.506
−45.354
−10.662
1.00
32.27
C


ATOM
8912
CG
LEU
B
54
−78.521
−44.702
−9.698
1.00
32.56
C


ATOM
8914
CD1
LEU
B
54
−79.275
−43.760
−8.769
1.00
32.38
C


ATOM
8918
CD2
LEU
B
54
−77.755
−45.789
−8.917
1.00
33.29
C


ATOM
8922
C
LEU
B
54
−78.870
−44.006
−12.634
1.00
31.50
C


ATOM
8923
O
LEU
B
54
−78.509
−42.840
−12.607
1.00
31.98
O


ATOM
8925
N
LEU
B
55
−78.297
−44.914
−13.418
1.00
30.43
N


ATOM
8926
CA
LEU
B
55
−77.220
−44.540
−14.333
1.00
29.36
C


ATOM
8928
CB
LEU
B
55
−76.765
−45.733
−15.173
1.00
29.23
C


ATOM
8931
CG
LEU
B
55
−76.157
−46.902
−14.391
1.00
28.60
C


ATOM
8933
CD1
LEU
B
55
−75.697
−48.004
−15.348
1.00
27.60
C


ATOM
8937
CD2
LEU
B
55
−75.020
−46.440
−13.469
1.00
27.20
C


ATOM
8941
C
LEU
B
55
−77.678
−43.406
−15.230
1.00
28.60
C


ATOM
8942
O
LEU
B
55
−77.063
−42.365
−15.267
1.00
28.17
O


ATOM
8944
N
GLU
B
56
−78.786
−43.594
−15.919
1.00
28.23
N


ATOM
8945
CA
GLU
B
56
−79.326
−42.530
−16.759
1.00
28.64
C


ATOM
8947
CB
GLU
B
56
−80.567
−43.031
−17.524
1.00
29.27
C


ATOM
8950
CG
GLU
B
56
−80.229
−43.783
−18.829
1.00
31.73
C


ATOM
8953
CD
GLU
B
56
−81.265
−44.860
−19.206
1.00
35.52
C


ATOM
8954
OE1
GLU
B
56
−82.474
−44.693
−18.889
1.00
36.97
O


ATOM
8955
OE2
GLU
B
56
−80.856
−45.877
−19.825
1.00
37.55
O


ATOM
8956
C
GLU
B
56
−79.632
−41.203
−15.995
1.00
27.77
C


ATOM
8957
O
GLU
B
56
−79.561
−40.103
−16.582
1.00
27.84
O


ATOM
8959
N
LEU
B
57
−79.976
−41.303
−14.710
1.00
26.29
N


ATOM
8960
CA
LEU
B
57
−80.158
−40.120
−13.895
1.00
25.06
C


ATOM
8962
CB
LEU
B
57
−80.724
−40.462
−12.514
1.00
24.83
C


ATOM
8965
CG
LEU
B
57
−80.952
−39.298
−11.544
1.00
23.72
C


ATOM
8967
CD1
LEU
B
57
−81.909
−38.278
−12.117
1.00
21.43
C


ATOM
8971
CD2
LEU
B
57
−81.477
−39.830
−10.227
1.00
22.41
C


ATOM
8975
C
LEU
B
57
−78.801
−39.459
−13.780
1.00
24.40
C


ATOM
8976
O
LEU
B
57
−78.591
−38.373
−14.306
1.00
24.70
O


ATOM
8978
N
ILE
B
58
−77.855
−40.133
−13.144
1.00
23.56
N


ATOM
8979
CA
ILE
B
58
−76.509
−39.574
−12.991
1.00
22.91
C


ATOM
8981
CB
ILE
B
58
−75.454
−40.635
−12.599
1.00
22.49
C


ATOM
8983
CG1
ILE
B
58
−75.753
−41.251
−11.235
1.00
22.09
C


ATOM
8986
CD1
ILE
B
58
−74.936
−42.464
−10.926
1.00
20.88
C


ATOM
8990
CG2
ILE
B
58
−74.103
−39.992
−12.534
1.00
22.63
C


ATOM
8994
C
ILE
B
58
−76.062
−38.927
−14.302
1.00
22.64
C


ATOM
8995
O
ILE
B
58
−75.603
−37.796
−14.315
1.00
22.38
O


ATOM
8997
N
ASP
B
59
−76.228
−39.646
−15.404
1.00
22.56
N


ATOM
8998
CA
ASP
B
59
−75.715
−39.196
−16.684
1.00
22.76
C


ATOM
9000
CB
ASP
B
59
−75.926
−40.269
−17.757
1.00
22.93
C


ATOM
9003
CG
ASP
B
59
−75.274
−39.904
−19.088
1.00
24.58
C


ATOM
9004
OD1
ASP
B
59
−74.157
−39.322
−19.081
1.00
25.70
O


ATOM
9005
OD2
ASP
B
59
−75.897
−40.186
−20.142
1.00
27.51
O


ATOM
9006
C
ASP
B
59
−76.343
−37.863
−17.104
1.00
22.40
C


ATOM
9007
O
ASP
B
59
−75.634
−36.939
−17.520
1.00
22.40
O


ATOM
9009
N
ASN
B
60
−77.662
−37.767
−16.991
1.00
21.91
N


ATOM
9010
CA
ASN
B
60
−78.349
−36.500
−17.217
1.00
21.70
C


ATOM
9012
CB
ASN
B
60
−79.867
−36.674
−17.088
1.00
22.12
C


ATOM
9015
CG
ASN
B
60
−80.477
−37.390
−18.268
1.00
22.76
C


ATOM
9016
OD1
ASN
B
60
−80.027
−37.233
−19.393
1.00
24.28
O


ATOM
9017
ND2
ASN
B
60
−81.515
−38.172
−18.017
1.00
24.36
N


ATOM
9020
C
ASN
B
60
−77.898
−35.427
−16.234
1.00
21.17
C


ATOM
9021
O
ASN
B
60
−77.700
−34.273
−16.614
1.00
20.85
O


ATOM
9023
N
VAL
B
61
−77.745
−35.805
−14.968
1.00
20.60
N


ATOM
9024
CA
VAL
B
61
−77.382
−34.841
−13.942
1.00
20.48
C


ATOM
9026
CB
VAL
B
61
−77.277
−35.490
−12.551
1.00
20.26
C


ATOM
9028
CG1
VAL
B
61
−76.585
−34.562
−11.565
1.00
19.92
C


ATOM
9032
CG2
VAL
B
61
−78.668
−35.857
−12.049
1.00
20.66
C


ATOM
9036
C
VAL
B
61
−76.068
−34.208
−14.335
1.00
20.66
C


ATOM
9037
O
VAL
B
61
−75.871
−32.998
−14.182
1.00
20.74
O


ATOM
9039
N
GLN
B
62
−75.187
−35.048
−14.875
1.00
20.92
N


ATOM
9040
CA
GLN
B
62
−73.854
−34.636
−15.285
1.00
20.69
C


ATOM
9042
CB
GLN
B
62
−72.917
−35.847
−15.404
1.00
20.77
C


ATOM
9045
CG
GLN
B
62
−72.456
−36.369
−14.035
1.00
20.91
C


ATOM
9048
CD
GLN
B
62
−71.328
−37.383
−14.112
1.00
20.75
C


ATOM
9049
OE1
GLN
B
62
−70.512
−37.498
−13.192
1.00
20.93
O


ATOM
9050
NE2
GLN
B
62
−71.291
−38.135
−15.195
1.00
20.39
N


ATOM
9053
C
GLN
B
62
−73.900
−33.834
−16.567
1.00
20.32
C


ATOM
9054
O
GLN
B
62
−73.410
−32.712
−16.569
1.00
20.79
O


ATOM
9056
N
ARG
B
63
−74.512
−34.373
−17.625
1.00
19.87
N


ATOM
9057
CA
ARG
B
63
−74.520
−33.696
−18.940
1.00
19.81
C


ATOM
9059
CB
ARG
B
63
−75.240
−34.536
−20.013
1.00
19.75
C


ATOM
9062
CG
ARG
B
63
−74.492
−35.846
−20.345
1.00
21.69
C


ATOM
9065
CD
ARG
B
63
−75.158
−36.786
−21.368
1.00
24.89
C


ATOM
9068
NE
ARG
B
63
−74.674
−36.558
−22.741
1.00
29.32
N


ATOM
9070
CZ
ARG
B
63
−75.323
−35.878
−23.702
1.00
33.71
C


ATOM
9071
NH1
ARG
B
63
−76.537
−35.345
−23.510
1.00
36.67
N


ATOM
9074
NH2
ARG
B
63
−74.761
−35.736
−24.894
1.00
34.58
N


ATOM
9077
C
ARG
B
63
−75.099
−32.276
−18.822
1.00
19.39
C


ATOM
9078
O
ARG
B
63
−74.553
−31.310
−19.395
1.00
19.63
O


ATOM
9080
N
LEU
B
64
−76.155
−32.148
−18.017
1.00
18.62
N


ATOM
9081
CA
LEU
B
64
−76.811
−30.856
−17.753
1.00
17.96
C


ATOM
9083
CB
LEU
B
64
−78.136
−31.077
−17.008
1.00
17.97
C


ATOM
9086
CG
LEU
B
64
−79.264
−31.737
−17.809
1.00
17.08
C


ATOM
9088
CD1
LEU
B
64
−80.276
−32.354
−16.879
1.00
15.15
C


ATOM
9092
CD2
LEU
B
64
−79.904
−30.734
−18.737
1.00
15.30
C


ATOM
9096
C
LEU
B
64
−75.975
−29.847
−16.966
1.00
17.39
C


ATOM
9097
O
LEU
B
64
−76.370
−28.685
−16.825
1.00
17.38
O


ATOM
9099
N
GLY
B
65
−74.848
−30.286
−16.432
1.00
16.73
N


ATOM
9100
CA
GLY
B
65
−73.917
−29.374
−15.818
1.00
16.65
C


ATOM
9103
C
GLY
B
65
−74.077
−29.249
−14.319
1.00
16.68
C


ATOM
9104
O
GLY
B
65
−73.565
−28.302
−13.718
1.00
16.79
O


ATOM
9106
N
LEU
B
66
−74.758
−30.209
−13.702
1.00
16.60
N


ATOM
9107
CA
LEU
B
66
−74.978
−30.177
−12.264
1.00
16.58
C


ATOM
9109
CB
LEU
B
66
−76.465
−30.389
−11.957
1.00
16.35
C


ATOM
9112
CG
LEU
B
66
−77.363
−29.187
−12.234
1.00
15.57
C


ATOM
9114
CD1
LEU
B
66
−78.828
−29.602
−12.163
1.00
15.26
C


ATOM
9118
CD2
LEU
B
66
−77.063
−28.051
−11.270
1.00
13.66
C


ATOM
9122
C
LEU
B
66
−74.129
−31.203
−11.513
1.00
16.94
C


ATOM
9123
O
LEU
B
66
−74.152
−31.251
−10.279
1.00
17.50
O


ATOM
9125
N
GLY
B
67
−73.373
−32.017
−12.236
1.00
17.03
N


ATOM
9126
CA
GLY
B
67
−72.541
−33.036
−11.602
1.00
17.13
C


ATOM
9129
C
GLY
B
67
−71.642
−32.557
−10.461
1.00
17.08
C


ATOM
9130
O
GLY
B
67
−71.378
−33.317
−9.522
1.00
17.33
O


ATOM
9132
N
TYR
B
68
−71.159
−31.316
−10.541
1.00
16.83
N


ATOM
9133
CA
TYR
B
68
−70.217
−30.804
−9.552
1.00
16.64
C


ATOM
9135
CB
TYR
B
68
−69.654
−29.437
−9.951
1.00
16.25
C


ATOM
9138
CG
TYR
B
68
−70.609
−28.273
−9.802
1.00
13.51
C


ATOM
9139
CD1
TYR
B
68
−70.521
−27.411
−8.738
1.00
10.49
C


ATOM
9141
CE1
TYR
B
68
−71.407
−26.342
−8.608
1.00
10.25
C


ATOM
9143
CZ
TYR
B
68
−72.382
−26.135
−9.555
1.00
9.74
C


ATOM
9144
OH
TYR
B
68
−73.253
−25.086
−9.450
1.00
7.62
O


ATOM
9146
CE2
TYR
B
68
−72.484
−26.978
−10.625
1.00
11.14
C


ATOM
9148
CD2
TYR
B
68
−71.603
−28.037
−10.748
1.00
12.56
C


ATOM
9150
C
TYR
B
68
−70.828
−30.700
−8.172
1.00
17.79
C


ATOM
9151
O
TYR
B
68
−70.107
−30.811
−7.182
1.00
18.00
O


ATOM
9153
N
ARG
B
69
−72.146
−30.485
−8.090
1.00
18.85
N


ATOM
9154
CA
ARG
B
69
−72.784
−30.269
−6.789
1.00
19.46
C


ATOM
9156
CB
ARG
B
69
−73.708
−29.047
−6.819
1.00
19.23
C


ATOM
9159
CG
ARG
B
69
−75.030
−29.219
−7.509
1.00
18.83
C


ATOM
9162
CD
ARG
B
69
−76.053
−28.192
−6.985
1.00
17.73
C


ATOM
9165
NE
ARG
B
69
−75.642
−26.830
−7.297
1.00
16.01
N


ATOM
9167
CZ
ARG
B
69
−75.330
−25.889
−6.417
1.00
14.68
C


ATOM
9168
NH1
ARG
B
69
−75.400
−26.093
−5.112
1.00
14.99
N


ATOM
9171
NH2
ARG
B
69
−74.959
−24.707
−6.861
1.00
15.04
N


ATOM
9174
C
ARG
B
69
−73.490
−31.489
−6.234
1.00
20.50
C


ATOM
9175
O
ARG
B
69
−74.084
−31.418
−5.163
1.00
20.67
O


ATOM
9177
N
PHE
B
70
−73.416
−32.607
−6.959
1.00
22.04
N


ATOM
9178
CA
PHE
B
70
−73.853
−33.917
−6.450
1.00
23.03
C


ATOM
9180
CB
PHE
B
70
−75.081
−34.428
−7.211
1.00
22.94
C


ATOM
9183
CG
PHE
B
70
−76.236
−33.503
−7.157
1.00
21.78
C


ATOM
9184
CD1
PHE
B
70
−77.024
−33.441
−6.028
1.00
20.54
C


ATOM
9186
CE1
PHE
B
70
−78.076
−32.571
−5.959
1.00
20.32
C


ATOM
9188
CZ
PHE
B
70
−78.353
−31.752
−7.025
1.00
20.73
C


ATOM
9190
CE2
PHE
B
70
−77.564
−31.796
−8.160
1.00
21.24
C


ATOM
9192
CD2
PHE
B
70
−76.511
−32.665
−8.220
1.00
21.22
C


ATOM
9194
C
PHE
B
70
−72.765
−34.962
−6.570
1.00
24.33
C


ATOM
9195
O
PHE
B
70
−73.069
−36.142
−6.614
1.00
24.56
O


ATOM
9197
N
GLU
B
71
−71.500
−34.547
−6.624
1.00
26.01
N


ATOM
9198
CA
GLU
B
71
−70.413
−35.506
−6.804
1.00
27.04
C


ATOM
9200
CB
GLU
B
71
−69.042
−34.824
−6.885
1.00
27.48
C


ATOM
9203
CG
GLU
B
71
−67.851
−35.816
−6.794
1.00
28.94
C


ATOM
9206
CD
GLU
B
71
−66.491
−35.192
−7.081
1.00
30.38
C


ATOM
9207
OE1
GLU
B
71
−66.398
−34.192
−7.835
1.00
30.52
O


ATOM
9208
OE2
GLU
B
71
−65.501
−35.730
−6.544
1.00
32.16
O


ATOM
9209
C
GLU
B
71
−70.436
−36.531
−5.680
1.00
27.46
C


ATOM
9210
O
GLU
B
71
−70.449
−37.723
−5.937
1.00
27.67
O


ATOM
9212
N
SER
B
72
−70.464
−36.087
−4.435
1.00
28.04
N


ATOM
9213
CA
SER
B
72
−70.381
−37.044
−3.348
1.00
28.86
C


ATOM
9215
CB
SER
B
72
−70.388
−36.340
−1.983
1.00
29.09
C


ATOM
9218
OG
SER
B
72
−71.649
−35.751
−1.687
1.00
30.21
O


ATOM
9220
C
SER
B
72
−71.519
−38.058
−3.481
1.00
29.30
C


ATOM
9221
O
SER
B
72
−71.304
−39.265
−3.384
1.00
29.24
O


ATOM
9223
N
ASP
B
73
−72.719
−37.560
−3.756
1.00
30.03
N


ATOM
9224
CA
ASP
B
73
−73.897
−38.417
−3.874
1.00
30.63
C


ATOM
9226
CB
ASP
B
73
−75.184
−37.598
−4.116
1.00
30.74
C


ATOM
9229
CG
ASP
B
73
−75.419
−36.509
−3.052
1.00
31.84
C


ATOM
9230
OD1
ASP
B
73
−75.562
−36.830
−1.841
1.00
31.70
O


ATOM
9231
OD2
ASP
B
73
−75.473
−35.317
−3.443
1.00
33.81
O


ATOM
9232
C
ASP
B
73
−73.722
−39.443
−4.994
1.00
30.81
C


ATOM
9233
O
ASP
B
73
−74.130
−40.590
−4.835
1.00
31.39
O


ATOM
9235
N
ILE
B
74
−73.122
−39.031
−6.112
1.00
30.96
N


ATOM
9236
CA
ILE
B
74
−72.917
−39.912
−7.282
1.00
31.04
C


ATOM
9238
CB
ILE
B
74
−72.461
−39.114
−8.524
1.00
30.88
C


ATOM
9240
CG1
ILE
B
74
−73.585
−38.213
−9.018
1.00
30.99
C


ATOM
9243
CD1
ILE
B
74
−73.105
−37.120
−9.923
1.00
31.54
C


ATOM
9247
CG2
ILE
B
74
−72.052
−40.035
−9.642
1.00
29.85
C


ATOM
9251
C
ILE
B
74
−71.885
−41.005
−6.999
1.00
31.45
C


ATOM
9252
O
ILE
B
74
−72.098
−42.165
−7.347
1.00
31.31
O


ATOM
9254
N
ARG
B
75
−70.768
−40.628
−6.380
1.00
31.93
N


ATOM
9255
CA
ARG
B
75
−69.778
−41.601
−5.947
1.00
32.38
C


ATOM
9257
CB
ARG
B
75
−68.629
−40.959
−5.137
1.00
32.87
C


ATOM
9260
CG
ARG
B
75
−67.310
−40.751
−5.915
1.00
35.01
C


ATOM
9263
CD
ARG
B
75
−66.089
−40.489
−5.003
1.00
37.62
C


ATOM
9266
NE
ARG
B
75
−65.260
−41.687
−4.783
1.00
41.03
N


ATOM
9268
CZ
ARG
B
75
−64.461
−42.253
−5.700
1.00
44.29
C


ATOM
9269
NH1
ARG
B
75
−64.385
−41.751
−6.931
1.00
46.22
N


ATOM
9272
NH2
ARG
B
75
−63.741
−43.341
−5.404
1.00
44.30
N


ATOM
9275
C
ARG
B
75
−70.478
−42.673
−5.126
1.00
32.18
C


ATOM
9276
O
ARG
B
75
−70.307
−43.849
−5.398
1.00
32.19
O


ATOM
9278
N
ARG
B
76
−71.280
−42.275
−4.143
1.00
32.21
N


ATOM
9279
CA
ARG
B
76
−71.975
−43.256
−3.307
1.00
32.61
C


ATOM
9281
CB
ARG
B
76
−72.737
−42.582
−2.162
1.00
32.75
C


ATOM
9284
CG
ARG
B
76
−71.880
−42.320
−.929
1.00
33.44
C


ATOM
9287
CD
ARG
B
76
−72.720
−42.046
.334
1.00
34.16
C


ATOM
9290
NE
ARG
B
76
−73.797
−41.074
.124
1.00
34.53
N


ATOM
9292
CZ
ARG
B
76
−73.627
−39.765
−.063
1.00
34.38
C


ATOM
9293
NH1
ARG
B
76
−72.414
−39.219
−.092
1.00
34.34
N


ATOM
9296
NH2
ARG
B
76
−74.689
−38.993
−.241
1.00
34.71
N


ATOM
9299
C
ARG
B
76
−72.918
−44.159
−4.112
1.00
32.81
C


ATOM
9300
O
ARG
B
76
−72.863
−45.379
−3.995
1.00
32.86
O


ATOM
9302
N
ALA
B
77
−73.780
−43.559
−4.923
1.00
33.10
N


ATOM
9303
CA
ALA
B
77
−74.655
−44.307
−5.813
1.00
33.27
C


ATOM
9305
CB
ALA
B
77
−75.321
−43.366
−6.770
1.00
33.26
C


ATOM
9309
C
ALA
B
77
−73.884
−45.370
−6.578
1.00
33.80
C


ATOM
9310
O
ALA
B
77
−74.235
−46.542
−6.559
1.00
33.75
O


ATOM
9312
N
LEU
B
78
−72.816
−44.952
−7.242
1.00
34.77
N


ATOM
9313
CA
LEU
B
78
−71.987
−45.868
−8.019
1.00
35.41
C


ATOM
9315
CB
LEU
B
78
−70.845
−45.109
−8.702
1.00
35.01
C


ATOM
9318
CG
LEU
B
78
−71.220
−44.092
−9.782
1.00
34.37
C


ATOM
9320
CD1
LEU
B
78
−69.945
−43.502
−10.381
1.00
33.93
C


ATOM
9324
CD2
LEU
B
78
−72.109
−44.692
−10.873
1.00
32.94
C


ATOM
9328
C
LEU
B
78
−71.409
−46.974
−7.142
1.00
36.50
C


ATOM
9329
O
LEU
B
78
−71.336
−48.124
−7.552
1.00
36.87
O


ATOM
9331
N
ASP
B
79
−71.005
−46.619
−5.931
1.00
37.74
N


ATOM
9332
CA
ASP
B
79
−70.308
−47.545
−5.056
1.00
38.74
C


ATOM
9334
CB
ASP
B
79
−69.787
−46.810
−3.819
1.00
38.99
C


ATOM
9337
CG
ASP
B
79
−68.499
−47.386
−3.313
1.00
40.08
C


ATOM
9338
OD1
ASP
B
79
−68.494
−48.591
−2.976
1.00
42.32
O


ATOM
9339
OD2
ASP
B
79
−67.494
−46.638
−3.261
1.00
41.24
O


ATOM
9340
C
ASP
B
79
−71.207
−48.705
−4.645
1.00
39.42
C


ATOM
9341
O
ASP
B
79
−70.736
−49.835
−4.505
1.00
39.58
O


ATOM
9343
N
ARG
B
80
−72.495
−48.424
−4.450
1.00
40.26
N


ATOM
9344
CA
ARG
B
80
−73.471
−49.470
−4.143
1.00
40.92
C


ATOM
9346
CB
ARG
B
80
−74.823
−48.881
−3.716
1.00
41.46
C


ATOM
9349
CG
ARG
B
80
−74.871
−48.247
−2.308
1.00
42.87
C


ATOM
9352
CD
ARG
B
80
−76.316
−47.826
−1.936
1.00
44.62
C


ATOM
9355
NE
ARG
B
80
−76.946
−46.968
−2.949
1.00
45.87
N


ATOM
9357
CZ
ARG
B
80
−76.741
−45.651
−3.089
1.00
46.82
C


ATOM
9358
NH1
ARG
B
80
−75.905
−44.989
−2.282
1.00
46.27
N


ATOM
9361
NH2
ARG
B
80
−77.378
−44.988
−4.059
1.00
47.22
N


ATOM
9364
C
ARG
B
80
−73.667
−50.341
−5.371
1.00
40.77
C


ATOM
9365
O
ARG
B
80
−73.642
−51.563
−5.275
1.00
41.06
O


ATOM
9367
N
PHE
B
81
−73.863
−49.705
−6.520
1.00
40.56
N


ATOM
9368
CA
PHE
B
81
−73.986
−50.418
−7.787
1.00
40.59
C


ATOM
9370
CB
PHE
B
81
−73.984
−49.426
−8.956
1.00
40.73
C


ATOM
9373
CG
PHE
B
81
−73.898
−50.063
−10.323
1.00
40.84
C


ATOM
9374
CD1
PHE
B
81
−75.000
−50.668
−10.893
1.00
41.39
C


ATOM
9376
CE1
PHE
B
81
−74.925
−51.236
−12.167
1.00
41.67
C


ATOM
9378
CZ
PHE
B
81
−73.741
−51.191
−12.877
1.00
41.33
C


ATOM
9380
CE2
PHE
B
81
−72.638
−50.580
−12.326
1.00
41.19
C


ATOM
9382
CD2
PHE
B
81
−72.720
−50.012
−11.057
1.00
41.39
C


ATOM
9384
C
PHE
B
81
−72.871
−51.441
−7.953
1.00
40.47
C


ATOM
9385
O
PHE
B
81
−73.134
−52.583
−8.311
1.00
40.85
O


ATOM
9387
N
VAL
B
82
−71.633
−51.051
−7.683
1.00
40.26
N


ATOM
9388
CA
VAL
B
82
−70.522
−51.986
−7.821
1.00
40.24
C


ATOM
9390
CB
VAL
B
82
−69.173
−51.386
−7.379
1.00
40.28
C


ATOM
9392
CG1
VAL
B
82
−68.164
−52.493
−7.063
1.00
39.98
C


ATOM
9396
CG2
VAL
B
82
−68.644
−50.462
−8.451
1.00
40.09
C


ATOM
9400
C
VAL
B
82
−70.788
−53.230
−7.005
1.00
40.16
C


ATOM
9401
O
VAL
B
82
−70.880
−54.313
−7.559
1.00
40.13
O


ATOM
9403
N
SER
B
83
−70.953
−53.056
−5.698
1.00
40.26
N


ATOM
9404
CA
SER
B
83
−71.070
−54.174
−4.749
1.00
40.43
C


ATOM
9406
CB
SER
B
83
−70.797
−53.666
−3.331
1.00
40.54
C


ATOM
9409
OG
SER
B
83
−71.256
−52.330
−3.191
1.00
40.89
O


ATOM
9411
C
SER
B
83
−72.415
−54.912
−4.831
1.00
40.34
C


ATOM
9412
O
SER
B
83
−73.137
−55.046
−3.845
1.00
39.99
O


ATOM
9414
N
SER
B
84
−72.698
−55.400
−6.038
1.00
40.57
N


ATOM
9415
CA
SER
B
84
−73.902
−56.154
−6.411
1.00
40.63
C


ATOM
9417
CB
SER
B
84
−75.154
−55.679
−5.651
1.00
40.56
C


ATOM
9420
OG
SER
B
84
−75.292
−54.268
−5.663
1.00
39.82
O


ATOM
9422
C
SER
B
84
−74.104
−56.026
−7.940
1.00
40.85
C


ATOM
9423
O
SER
B
84
−75.104
−55.462
−8.395
1.00
41.24
O


ATOM
9425
N
GLY
B
85
−73.136
−56.524
−8.720
1.00
40.75
N


ATOM
9426
CA
GLY
B
85
−73.201
−56.506
−10.191
1.00
40.64
C


ATOM
9429
C
GLY
B
85
−73.225
−55.120
−10.815
1.00
40.64
C


ATOM
9430
O
GLY
B
85
−74.133
−54.794
−11.590
1.00
40.32
O


ATOM
9432
N
THR
B
93
−74.847
−57.360
−18.759
1.00
36.30
N


ATOM
9433
CA
THR
B
93
−75.593
−58.129
−19.774
1.00
35.99
C


ATOM
9435
CB
THR
B
93
−76.251
−59.379
−19.152
1.00
35.87
C


ATOM
9437
OG1
THR
B
93
−76.347
−60.389
−20.158
1.00
35.64
O


ATOM
9439
CG2
THR
B
93
−77.646
−59.062
−18.548
1.00
34.95
C


ATOM
9443
C
THR
B
93
−76.625
−57.274
−20.583
1.00
35.90
C


ATOM
9444
O
THR
B
93
−77.764
−57.688
−20.843
1.00
35.74
O


ATOM
9446
N
SER
B
94
−76.175
−56.076
−20.963
1.00
35.58
N


ATOM
9447
CA
SER
B
94
−76.874
−55.150
−21.866
1.00
34.97
C


ATOM
9449
CB
SER
B
94
−78.074
−54.472
−21.190
1.00
35.06
C


ATOM
9452
OG
SER
B
94
−77.702
−53.260
−20.541
1.00
34.37
O


ATOM
9454
C
SER
B
94
−75.831
−54.097
−22.232
1.00
34.39
C


ATOM
9455
O
SER
B
94
−75.212
−53.518
−21.341
1.00
34.11
O


ATOM
9457
N
LEU
B
95
−75.619
−53.864
−23.522
1.00
33.77
N


ATOM
9458
CA
LEU
B
95
−74.490
−53.045
−23.952
1.00
33.33
C


ATOM
9460
CB
LEU
B
95
−74.373
−53.010
−25.475
1.00
33.30
C


ATOM
9463
CG
LEU
B
95
−73.154
−52.246
−26.006
1.00
33.27
C


ATOM
9465
CD1
LEU
B
95
−71.909
−52.455
−25.137
1.00
32.89
C


ATOM
9469
CD2
LEU
B
95
−72.864
−52.649
−27.438
1.00
33.19
C


ATOM
9473
C
LEU
B
95
−74.551
−51.623
−23.413
1.00
33.00
C


ATOM
9474
O
LEU
B
95
−73.588
−51.151
−22.809
1.00
32.83
O


ATOM
9476
N
HIS
B
96
−75.678
−50.949
−23.633
1.00
32.64
N


ATOM
9477
CA
HIS
B
96
−75.853
−49.576
−23.171
1.00
32.39
C


ATOM
9479
CB
HIS
B
96
−77.246
−49.069
−23.527
1.00
32.64
C


ATOM
9482
CG
HIS
B
96
−77.528
−47.689
−23.025
1.00
34.16
C


ATOM
9483
ND1
HIS
B
96
−76.565
−46.703
−22.981
1.00
36.21
N


ATOM
9485
CE1
HIS
B
96
−77.096
−45.594
−22.496
1.00
36.92
C


ATOM
9487
NE2
HIS
B
96
−78.371
−45.827
−22.227
1.00
37.06
N


ATOM
9489
CD2
HIS
B
96
−78.664
−47.130
−22.548
1.00
35.43
C


ATOM
9491
C
HIS
B
96
−75.612
−49.445
−21.665
1.00
31.78
C


ATOM
9492
O
HIS
B
96
−74.936
−48.523
−21.215
1.00
31.95
O


ATOM
9494
N
GLY
B
97
−76.156
−50.372
−20.887
1.00
31.10
N


ATOM
9495
CA
GLY
B
97
−75.907
−50.396
−19.446
1.00
30.52
C


ATOM
9498
C
GLY
B
97
−74.434
−50.532
−19.085
1.00
29.95
C


ATOM
9499
O
GLY
B
97
−73.936
−49.797
−18.241
1.00
30.21
O


ATOM
9501
N
THR
B
98
−73.740
−51.470
−19.726
1.00
29.15
N


ATOM
9502
CA
THR
B
98
−72.314
−51.690
−19.490
1.00
28.55
C


ATOM
9504
CB
THR
B
98
−71.803
−52.955
−20.248
1.00
28.48
C


ATOM
9506
OG1
THR
B
98
−72.678
−54.066
−19.997
1.00
28.41
O


ATOM
9508
CG2
THR
B
98
−70.405
−53.331
−19.816
1.00
27.74
C


ATOM
9512
C
THR
B
98
−71.492
−50.452
−19.894
1.00
28.31
C


ATOM
9513
O
THR
B
98
−70.658
−49.979
−19.127
1.00
28.13
O


ATOM
9515
N
ALA
B
99
−71.750
−49.910
−21.080
1.00
28.04
N


ATOM
9516
CA
ALA
B
99
−70.984
−48.758
−21.578
1.00
27.88
C


ATOM
9518
CB
ALA
B
99
−71.387
−48.406
−23.014
1.00
27.78
C


ATOM
9522
C
ALA
B
99
−71.127
−47.538
−20.684
1.00
27.62
C


ATOM
9523
O
ALA
B
99
−70.135
−46.885
−20.361
1.00
27.84
O


ATOM
9525
N
LEU
B
100
−72.357
−47.233
−20.290
1.00
27.20
N


ATOM
9526
CA
LEU
B
100
−72.613
−46.088
−19.422
1.00
27.08
C


ATOM
9528
CB
LEU
B
100
−74.122
−45.900
−19.230
1.00
26.95
C


ATOM
9531
CG
LEU
B
100
−74.560
−44.715
−18.367
1.00
26.27
C


ATOM
9533
CD1
LEU
B
100
−73.753
−43.478
−18.734
1.00
26.19
C


ATOM
9537
CD2
LEU
B
100
−76.052
−44.445
−18.504
1.00
25.20
C


ATOM
9541
C
LEU
B
100
−71.928
−46.221
−18.046
1.00
27.23
C


ATOM
9542
O
LEU
B
100
−71.368
−45.243
−17.523
1.00
27.16
O


ATOM
9544
N
SER
B
101
−71.980
−47.429
−17.472
1.00
27.00
N


ATOM
9545
CA
SER
B
101
−71.475
−47.682
−16.117
1.00
26.63
C


ATOM
9547
CB
SER
B
101
−72.039
−48.992
−15.568
1.00
26.49
C


ATOM
9550
OG
SER
B
101
−71.758
−50.063
−16.442
1.00
26.38
O


ATOM
9552
C
SER
B
101
−69.956
−47.740
−16.090
1.00
26.47
C


ATOM
9553
O
SER
B
101
−69.326
−47.324
−15.121
1.00
26.35
O


ATOM
9555
N
PHE
B
102
−69.381
−48.288
−17.154
1.00
26.29
N


ATOM
9556
CA
PHE
B
102
−67.934
−48.332
−17.322
1.00
25.91
C


ATOM
9558
CB
PHE
B
102
−67.588
−49.005
−18.652
1.00
25.96
C


ATOM
9561
CG
PHE
B
102
−66.133
−49.020
−18.958
1.00
25.81
C


ATOM
9562
CD1
PHE
B
102
−65.360
−50.115
−18.633
1.00
25.96
C


ATOM
9564
CE1
PHE
B
102
−63.999
−50.122
−18.909
1.00
26.94
C


ATOM
9566
CZ
PHE
B
102
−63.403
−49.026
−19.519
1.00
26.27
C


ATOM
9568
CE2
PHE
B
102
−64.174
−47.930
−19.848
1.00
26.19
C


ATOM
9570
CD2
PHE
B
102
−65.531
−47.933
−19.573
1.00
26.04
C


ATOM
9572
C
PHE
B
102
−67.416
−46.911
−17.315
1.00
25.56
C


ATOM
9573
O
PHE
B
102
−66.486
−46.564
−16.568
1.00
25.37
O


ATOM
9575
N
ARG
B
103
−68.050
−46.095
−18.152
1.00
25.20
N


ATOM
9576
CA
ARG
B
103
−67.663
−44.696
−18.322
1.00
25.09
C


ATOM
9578
CB
ARG
B
103
−68.510
−44.026
−19.400
1.00
25.12
C


ATOM
9581
CG
ARG
B
103
−68.194
−42.561
−19.572
1.00
25.41
C


ATOM
9584
CD
ARG
B
103
−68.744
−42.035
−20.889
1.00
26.68
C


ATOM
9587
NE
ARG
B
103
−70.197
−41.843
−20.877
1.00
27.49
N


ATOM
9589
CZ
ARG
B
103
−70.826
−40.851
−20.246
1.00
26.56
C


ATOM
9590
NH1
ARG
B
103
−70.139
−39.963
−19.531
1.00
27.11
N


ATOM
9593
NH2
ARG
B
103
−72.148
−40.759
−20.310
1.00
25.20
N


ATOM
9596
C
ARG
B
103
−67.785
−43.898
−17.033
1.00
24.61
C


ATOM
9597
O
ARG
B
103
−66.865
−43.168
−16.659
1.00
24.67
O


ATOM
9599
N
LEU
B
104
−68.927
−44.013
−16.371
1.00
23.79
N


ATOM
9600
CA
LEU
B
104
−69.125
−43.263
−15.148
1.00
23.23
C


ATOM
9602
CB
LEU
B
104
−70.591
−43.342
−14.693
1.00
23.01
C


ATOM
9605
CG
LEU
B
104
−71.607
−42.620
−15.584
1.00
21.36
C


ATOM
9607
CD1
LEU
B
104
−73.002
−42.860
−15.067
1.00
19.31
C


ATOM
9611
CD2
LEU
B
104
−71.310
−41.157
−15.633
1.00
19.57
C


ATOM
9615
C
LEU
B
104
−68.156
−43.781
−14.071
1.00
23.15
C


ATOM
9616
O
LEU
B
104
−67.445
−43.007
−13.423
1.00
23.40
O


ATOM
9618
N
LEU
B
105
−68.106
−45.091
−13.894
1.00
22.79
N


ATOM
9619
CA
LEU
B
105
−67.203
−45.659
−12.916
1.00
22.40
C


ATOM
9621
CB
LEU
B
105
−67.303
−47.178
−12.912
1.00
22.42
C


ATOM
9624
CG
LEU
B
105
−68.505
−47.709
−12.163
1.00
21.82
C


ATOM
9626
CD1
LEU
B
105
−68.810
−49.120
−12.591
1.00
21.95
C


ATOM
9630
CD2
LEU
B
105
−68.201
−47.648
−10.692
1.00
22.14
C


ATOM
9634
C
LEU
B
105
−65.767
−45.239
−13.196
1.00
22.33
C


ATOM
9635
O
LEU
B
105
−65.049
−44.823
−12.275
1.00
22.13
O


ATOM
9637
N
ARG
B
106
−65.331
−45.342
−14.451
1.00
22.08
N


ATOM
9638
CA
ARG
B
106
−63.953
−44.973
−14.730
1.00
22.20
C


ATOM
9640
CB
ARG
B
106
−63.521
−45.266
−16.151
1.00
22.33
C


ATOM
9643
CG
ARG
B
106
−62.075
−44.827
−16.329
1.00
23.60
C


ATOM
9646
CD
ARG
B
106
−61.383
−45.445
−17.513
1.00
24.71
C


ATOM
9649
NE
ARG
B
106
−61.078
−46.852
−17.319
1.00
24.66
N


ATOM
9651
CZ
ARG
B
106
−60.418
−47.582
−18.206
1.00
25.75
C


ATOM
9652
NH1
ARG
B
106
−59.995
−47.028
−19.337
1.00
26.41
N


ATOM
9655
NH2
ARG
B
106
−60.182
−48.866
−17.971
1.00
26.54
N


ATOM
9658
C
ARG
B
106
−63.732
−43.504
−14.438
1.00
21.75
C


ATOM
9659
O
ARG
B
106
−62.801
−43.145
−13.725
1.00
21.50
O


ATOM
9661
N
GLN
B
107
−64.609
−42.680
−15.003
1.00
21.69
N


ATOM
9662
CA
GLN
B
107
−64.630
−41.239
−14.794
1.00
21.64
C


ATOM
9664
CB
GLN
B
107
−65.964
−40.664
−15.261
1.00
21.71
C


ATOM
9667
CG
GLN
B
107
−66.169
−39.178
−14.929
1.00
21.97
C


ATOM
9670
CD
GLN
B
107
−67.588
−38.723
−15.172
1.00
21.54
C


ATOM
9671
OE1
GLN
B
107
−68.355
−39.365
−15.906
1.00
20.08
O


ATOM
9672
NE2
GLN
B
107
−67.948
−37.600
−14.556
1.00
21.45
N


ATOM
9675
C
GLN
B
107
−64.454
−40.850
−13.352
1.00
21.70
C


ATOM
9676
O
GLN
B
107
−63.776
−39.865
−13.078
1.00
22.14
O


ATOM
9678
N
HIS
B
108
−65.091
−41.599
−12.450
1.00
21.53
N


ATOM
9679
CA
HIS
B
108
−65.049
−41.326
−11.019
1.00
21.63
C


ATOM
9681
CB
HIS
B
108
−66.447
−41.535
−10.429
1.00
21.47
C


ATOM
9684
CG
HIS
B
108
−67.416
−40.445
−10.752
1.00
20.91
C


ATOM
9685
ND1
HIS
B
108
−67.541
−39.315
−9.976
1.00
20.66
N


ATOM
9687
CE1
HIS
B
108
−68.476
−38.535
−10.490
1.00
20.90
C


ATOM
9689
NE2
HIS
B
108
−68.966
−39.118
−11.567
1.00
19.67
N


ATOM
9691
CD2
HIS
B
108
−68.326
−40.320
−11.747
1.00
20.76
C


ATOM
9693
C
HIS
B
108
−64.024
−42.209
−10.269
1.00
22.22
C


ATOM
9694
O
HIS
B
108
−64.220
−42.553
−9.104
1.00
22.17
O


ATOM
9696
N
GLY
B
109
−62.950
−42.613
−10.933
1.00
22.91
N


ATOM
9697
CA
GLY
B
109
−61.846
−43.288
−10.245
1.00
23.85
C


ATOM
9700
C
GLY
B
109
−61.986
−44.748
−9.800
1.00
24.50
C


ATOM
9701
O
GLY
B
109
−61.053
−45.306
−9.189
1.00
24.12
O


ATOM
9703
N
PHE
B
110
−63.128
−45.371
−10.094
1.00
25.16
N


ATOM
9704
CA
PHE
B
110
−63.309
−46.791
−9.800
1.00
25.67
C


ATOM
9706
CB
PHE
B
110
−64.782
−47.187
−9.891
1.00
25.80
C


ATOM
9709
CG
PHE
B
110
−65.625
−46.656
−8.772
1.00
26.12
C


ATOM
9710
CD1
PHE
B
110
−65.564
−47.230
−7.510
1.00
27.13
C


ATOM
9712
CE1
PHE
B
110
−66.353
−46.751
−6.468
1.00
27.42
C


ATOM
9714
CZ
PHE
B
110
−67.215
−45.691
−6.692
1.00
26.93
C


ATOM
9716
CE2
PHE
B
110
−67.284
−45.119
−7.954
1.00
26.49
C


ATOM
9718
CD2
PHE
B
110
−66.494
−45.601
−8.981
1.00
25.96
C


ATOM
9720
C
PHE
B
110
−62.505
−47.615
−10.793
1.00
25.92
C


ATOM
9721
O
PHE
B
110
−62.232
−47.157
−11.898
1.00
26.41
O


ATOM
9723
N
GLU
B
111
−62.134
−48.832
−10.406
1.00
26.06
N


ATOM
9724
CA
GLU
B
111
−61.403
−49.724
−11.304
1.00
26.17
C


ATOM
9726
CB
GLU
B
111
−60.444
−50.609
−10.511
1.00
26.50
C


ATOM
9729
CG
GLU
B
111
−59.372
−51.272
−11.374
1.00
28.11
C


ATOM
9732
CD
GLU
B
111
−58.607
−52.377
−10.646
1.00
30.70
C


ATOM
9733
OE1
GLU
B
111
−58.660
−52.436
−9.390
1.00
31.99
O


ATOM
9734
OE2
GLU
B
111
−57.948
−53.190
−11.338
1.00
32.09
O


ATOM
9735
C
GLU
B
111
−62.355
−50.598
−12.130
1.00
25.60
C


ATOM
9736
O
GLU
B
111
−63.116
−51.388
−11.585
1.00
25.48
O


ATOM
9738
N
VAL
B
112
−62.314
−50.439
−13.447
1.00
25.24
N


ATOM
9739
CA
VAL
B
112
−63.026
−51.331
−14.357
1.00
24.90
C


ATOM
9741
CB
VAL
B
112
−64.308
−50.712
−14.908
1.00
24.92
C


ATOM
9743
CG1
VAL
B
112
−65.268
−50.437
−13.771
1.00
25.26
C


ATOM
9747
CG2
VAL
B
112
−63.999
−49.450
−15.706
1.00
24.77
C


ATOM
9751
C
VAL
B
112
−62.144
−51.701
−15.522
1.00
24.66
C


ATOM
9752
O
VAL
B
112
−61.217
−50.964
−15.862
1.00
23.80
O


ATOM
9754
N
SER
B
113
−62.467
−52.842
−16.132
1.00
24.88
N


ATOM
9755
CA
SER
B
113
−61.604
−53.494
−17.109
1.00
25.21
C


ATOM
9757
CB
SER
B
113
−61.286
−54.913
−16.654
1.00
24.94
C


ATOM
9760
OG
SER
B
113
−60.357
−55.523
−17.528
1.00
24.31
O


ATOM
9762
C
SER
B
113
−62.233
−53.532
−18.492
1.00
25.88
C


ATOM
9763
O
SER
B
113
−63.446
−53.651
−18.630
1.00
25.86
O


ATOM
9765
N
GLN
B
114
−61.406
−53.438
−19.526
1.00
26.92
N


ATOM
9766
CA
GLN
B
114
−61.928
−53.491
−20.880
1.00
27.83
C


ATOM
9768
CB
GLN
B
114
−60.846
−53.194
−21.917
1.00
27.75
C


ATOM
9771
CG
GLN
B
114
−59.559
−53.952
−21.726
1.00
28.05
C


ATOM
9774
CD
GLN
B
114
−58.739
−54.077
−23.007
1.00
28.39
C


ATOM
9775
OE1
GLN
B
114
−59.086
−53.515
−24.051
1.00
29.05
O


ATOM
9776
NE2
GLN
B
114
−57.637
−54.808
−22.925
1.00
27.62
N


ATOM
9779
C
GLN
B
114
−62.615
−54.827
−21.158
1.00
28.78
C


ATOM
9780
O
GLN
B
114
−63.484
−54.905
−22.022
1.00
29.10
O


ATOM
9782
N
GLU
B
115
−62.248
−55.861
−20.401
1.00
29.99
N


ATOM
9783
CA
GLU
B
115
−62.888
−57.181
−20.505
1.00
30.89
C


ATOM
9785
CB
GLU
B
115
−62.252
−58.202
−19.549
1.00
31.10
C


ATOM
9788
CG
GLU
B
115
−60.740
−58.394
−19.697
1.00
32.35
C


ATOM
9791
CD
GLU
B
115
−60.320
−58.796
−21.106
1.00
34.20
C


ATOM
9792
OE1
GLU
B
115
−60.965
−59.699
−21.688
1.00
34.94
O


ATOM
9793
OE2
GLU
B
115
−59.348
−58.201
−21.634
1.00
35.60
O


ATOM
9794
C
GLU
B
115
−64.380
−57.120
−20.224
1.00
31.26
C


ATOM
9795
O
GLU
B
115
−65.125
−57.971
−20.691
1.00
31.54
O


ATOM
9797
N
ALA
B
116
−64.825
−56.127
−19.465
1.00
31.91
N


ATOM
9798
CA
ALA
B
116
−66.255
−55.937
−19.259
1.00
32.69
C


ATOM
9800
CB
ALA
B
116
−66.521
−54.648
−18.513
1.00
32.62
C


ATOM
9804
C
ALA
B
116
−66.999
−55.950
−20.597
1.00
33.33
C


ATOM
9805
O
ALA
B
116
−68.156
−56.364
−20.668
1.00
33.26
O


ATOM
9807
N
PHE
B
117
−66.316
−55.521
−21.655
1.00
34.16
N


ATOM
9808
CA
PHE
B
117
−66.889
−55.498
−22.996
1.00
34.98
C


ATOM
9810
CB
PHE
B
117
−66.310
−54.314
−23.766
1.00
35.02
C


ATOM
9813
CG
PHE
B
117
−66.868
−52.997
−23.345
1.00
35.06
C


ATOM
9814
CD1
PHE
B
117
−66.061
−52.046
−22.729
1.00
35.33
C


ATOM
9816
CE1
PHE
B
117
−66.576
−50.825
−22.342
1.00
35.16
C


ATOM
9818
CZ
PHE
B
117
−67.907
−50.544
−22.570
1.00
35.37
C


ATOM
9820
CE2
PHE
B
117
−68.723
−51.488
−23.187
1.00
35.28
C


ATOM
9822
CD2
PHE
B
117
−68.201
−52.701
−23.571
1.00
34.68
C


ATOM
9824
C
PHE
B
117
−66.676
−56.766
−23.830
1.00
35.86
C


ATOM
9825
O
PHE
B
117
−66.934
−56.755
−25.037
1.00
35.91
O


ATOM
9827
N
SER
B
118
−66.215
−57.853
−23.212
1.00
36.98
N


ATOM
9828
CA
SER
B
118
−65.924
−59.086
−23.960
1.00
37.76
C


ATOM
9830
CB
SER
B
118
−64.836
−59.907
−23.262
1.00
37.73
C


ATOM
9833
OG
SER
B
118
−65.272
−60.346
−21.987
1.00
37.77
O


ATOM
9835
C
SER
B
118
−67.178
−59.939
−24.215
1.00
38.48
C


ATOM
9836
O
SER
B
118
−67.207
−60.724
−25.157
1.00
38.42
O


ATOM
9838
N
GLY
B
119
−68.221
−59.765
−23.407
1.00
39.51
N


ATOM
9839
CA
GLY
B
119
−69.481
−60.473
−23.629
1.00
40.51
C


ATOM
9842
C
GLY
B
119
−70.287
−60.034
−24.848
1.00
41.51
C


ATOM
9843
O
GLY
B
119
−71.444
−60.433
−25.002
1.00
41.53
O


ATOM
9845
N
PHE
B
120
−69.688
−59.210
−25.709
1.00
42.79
N


ATOM
9846
CA
PHE
B
120
−70.382
−58.621
−26.864
1.00
43.81
C


ATOM
9848
CB
PHE
B
120
−70.643
−57.121
−26.601
1.00
43.76
C


ATOM
9851
CG
PHE
B
120
−71.367
−56.853
−25.293
1.00
43.65
C


ATOM
9852
CD1
PHE
B
120
−72.762
−56.874
−25.230
1.00
43.48
C


ATOM
9854
CE1
PHE
B
120
−73.437
−56.650
−24.023
1.00
43.03
C


ATOM
9856
CZ
PHE
B
120
−72.717
−56.413
−22.865
1.00
43.09
C


ATOM
9858
CE2
PHE
B
120
−71.323
−56.397
−22.909
1.00
43.38
C


ATOM
9860
CD2
PHE
B
120
−70.655
−56.619
−24.120
1.00
43.41
C


ATOM
9862
C
PHE
B
120
−69.607
−58.832
−28.175
1.00
44.81
C


ATOM
9863
O
PHE
B
120
−69.930
−58.238
−29.205
1.00
44.65
O


ATOM
9865
N
LYS
B
121
−68.602
−59.705
−28.126
1.00
46.19
N


ATOM
9866
CA
LYS
B
121
−67.757
−60.004
−29.272
1.00
47.31
C


ATOM
9868
CB
LYS
B
121
−66.275
−59.928
−28.870
1.00
47.47
C


ATOM
9871
CG
LYS
B
121
−65.743
−58.495
−28.637
1.00
48.13
C


ATOM
9874
CD
LYS
B
121
−64.532
−58.439
−27.675
1.00
48.89
C


ATOM
9877
CE
LYS
B
121
−63.261
−59.094
−28.241
1.00
49.20
C


ATOM
9880
NZ
LYS
B
121
−62.541
−58.232
−29.218
1.00
49.04
N


ATOM
9884
C
LYS
B
121
−68.096
−61.400
−29.810
1.00
48.15
C


ATOM
9885
O
LYS
B
121
−68.199
−62.361
−29.043
1.00
48.36
O


ATOM
9887
N
ASP
B
122
−68.270
−61.510
−31.126
1.00
49.04
N


ATOM
9888
CA
ASP
B
122
−68.611
−62.788
−31.754
1.00
49.60
C


ATOM
9890
CB
ASP
B
122
−69.070
−62.596
−33.217
1.00
49.52
C


ATOM
9893
CG
ASP
B
122
−67.989
−62.015
−34.126
1.00
49.18
C


ATOM
9894
OD1
ASP
B
122
−66.792
−62.306
−33.938
1.00
48.96
O


ATOM
9895
OD2
ASP
B
122
−68.351
−61.268
−35.057
1.00
48.82
O


ATOM
9896
C
ASP
B
122
−67.455
−63.785
−31.651
1.00
50.31
C


ATOM
9897
O
ASP
B
122
−66.369
−63.441
−31.171
1.00
50.33
O


ATOM
9899
N
GLN
B
123
−67.705
−65.014
−32.098
1.00
51.05
N


ATOM
9900
CA
GLN
B
123
−66.716
−66.095
−32.057
1.00
51.61
C


ATOM
9902
CB
GLN
B
123
−67.263
−67.330
−32.785
1.00
51.82
C


ATOM
9905
CG
GLN
B
123
−68.483
−67.986
−32.117
1.00
52.32
C


ATOM
9908
CD
GLN
B
123
−68.117
−69.137
−31.184
1.00
52.64
C


ATOM
9909
OE1
GLN
B
123
−67.146
−69.062
−30.432
1.00
53.02
O


ATOM
9910
NE2
GLN
B
123
−68.904
−70.207
−31.230
1.00
52.04
N


ATOM
9913
C
GLN
B
123
−65.358
−65.694
−32.659
1.00
51.78
C


ATOM
9914
O
GLN
B
123
−64.309
−66.000
−32.090
1.00
51.67
O


ATOM
9916
N
ASN
B
124
−65.388
−65.004
−33.799
1.00
52.05
N


ATOM
9917
CA
ASN
B
124
−64.166
−64.547
−34.473
1.00
52.25
C


ATOM
9919
CB
ASN
B
124
−64.486
−64.042
−35.884
1.00
52.25
C


ATOM
9922
CG
ASN
B
124
−64.911
−65.158
−36.819
1.00
51.88
C


ATOM
9923
OD1
ASN
B
124
−65.918
−65.825
−36.592
1.00
51.43
O


ATOM
9924
ND2
ASN
B
124
−64.144
−65.364
−37.880
1.00
51.23
N


ATOM
9927
C
ASN
B
124
−63.382
−63.466
−33.716
1.00
52.43
C


ATOM
9928
O
ASN
B
124
−62.189
−63.287
−33.959
1.00
52.33
O


ATOM
9930
N
GLY
B
125
−64.051
−62.747
−32.815
1.00
52.66
N


ATOM
9931
CA
GLY
B
125
−63.396
−61.745
−31.968
1.00
52.68
C


ATOM
9934
C
GLY
B
125
−63.916
−60.329
−32.135
1.00
52.63
C


ATOM
9935
O
GLY
B
125
−63.539
−59.447
−31.367
1.00
52.57
O


ATOM
9937
N
ASN
B
126
−64.782
−60.117
−33.129
1.00
52.54
N


ATOM
9938
CA
ASN
B
126
−65.343
−58.793
−33.443
1.00
52.41
C


ATOM
9940
CB
ASN
B
126
−65.575
−58.671
−34.949
1.00
52.40
C


ATOM
9943
CG
ASN
B
126
−64.322
−58.951
−35.751
1.00
52.64
C


ATOM
9944
OD1
ASN
B
126
−63.426
−59.665
−35.297
1.00
52.77
O


ATOM
9945
ND2
ASN
B
126
−64.249
−58.390
−36.952
1.00
53.00
N


ATOM
9948
C
ASN
B
126
−66.656
−58.524
−32.712
1.00
52.10
C


ATOM
9949
O
ASN
B
126
−67.253
−59.432
−32.153
1.00
52.27
O


ATOM
9951
N
PHE
B
127
−67.111
−57.279
−32.724
1.00
51.61
N


ATOM
9952
CA
PHE
B
127
−68.362
−56.936
−32.055
1.00
51.23
C


ATOM
9954
CB
PHE
B
127
−68.506
−55.416
−31.905
1.00
51.21
C


ATOM
9957
CG
PHE
B
127
−67.702
−54.848
−30.770
1.00
50.58
C


ATOM
9958
CD1
PHE
B
127
−66.513
−54.192
−31.003
1.00
50.15
C


ATOM
9960
CE1
PHE
B
127
−65.777
−53.686
−29.948
1.00
50.15
C


ATOM
9962
CZ
PHE
B
127
−66.225
−53.839
−28.647
1.00
49.71
C


ATOM
9964
CE2
PHE
B
127
−67.399
−54.496
−28.405
1.00
49.50
C


ATOM
9966
CD2
PHE
B
127
−68.132
−54.999
−29.459
1.00
49.99
C


ATOM
9968
C
PHE
B
127
−69.537
−57.505
−32.821
1.00
50.99
C


ATOM
9969
O
PHE
B
127
−69.468
−57.641
−34.040
1.00
50.92
O


ATOM
9971
N
LEU
B
128
−70.609
−57.840
−32.106
1.00
50.83
N


ATOM
9972
CA
LEU
B
128
−71.799
−58.422
−32.731
1.00
50.76
C


ATOM
9974
CB
LEU
B
128
−72.780
−58.953
−31.669
1.00
50.80
C


ATOM
9977
CG
LEU
B
128
−72.341
−60.098
−30.734
1.00
50.91
C


ATOM
9979
CD1
LEU
B
128
−73.483
−60.532
−29.813
1.00
50.61
C


ATOM
9983
CD2
LEU
B
128
−71.818
−61.303
−31.497
1.00
50.79
C


ATOM
9987
C
LEU
B
128
−72.500
−57.407
−33.646
1.00
50.55
C


ATOM
9988
O
LEU
B
128
−73.105
−56.455
−33.171
1.00
50.34
O


ATOM
9990
N
GLU
B
129
−72.402
−57.628
−34.957
1.00
50.50
N


ATOM
9991
CA
GLU
B
129
−73.038
−56.783
−35.982
1.00
50.48
C


ATOM
9993
CB
GLU
B
129
−73.150
−57.551
−37.310
1.00
50.68
C


ATOM
9996
CG
GLU
B
129
−72.262
−57.024
−38.434
1.00
51.36
C


ATOM
9999
CD
GLU
B
129
−72.799
−55.745
−39.060
1.00
51.88
C


ATOM
10000
OE1
GLU
B
129
−72.110
−54.707
−38.961
1.00
52.72
O


ATOM
10001
OE2
GLU
B
129
−73.906
−55.773
−39.643
1.00
51.58
O


ATOM
10002
C
GLU
B
129
−74.428
−56.264
−35.629
1.00
50.25
C


ATOM
10003
O
GLU
B
129
−74.737
−55.110
−35.899
1.00
50.18
O


ATOM
10005
N
ASN
B
130
−75.263
−57.125
−35.047
1.00
50.06
N


ATOM
10006
CA
ASN
B
130
−76.678
−56.806
−34.785
1.00
49.71
C


ATOM
10008
CB
ASN
B
130
−77.477
−58.100
−34.550
1.00
49.69
C


ATOM
10011
CG
ASN
B
130
−77.053
−58.837
−33.291
1.00
49.39
C


ATOM
10012
OD1
ASN
B
130
−76.357
−59.848
−33.361
1.00
48.74
O


ATOM
10013
ND2
ASN
B
130
−77.468
−58.329
−32.134
1.00
48.99
N


ATOM
10016
C
ASN
B
130
−76.934
−55.800
−33.646
1.00
49.37
C


ATOM
10017
O
ASN
B
130
−78.083
−55.456
−33.366
1.00
49.29
O


ATOM
10019
N
LEU
B
131
−75.868
−55.336
−32.996
1.00
48.98
N


ATOM
10020
CA
LEU
B
131
−75.957
−54.279
−31.988
1.00
48.56
C


ATOM
10022
CB
LEU
B
131
−74.797
−54.392
−30.991
1.00
48.44
C


ATOM
10025
CG
LEU
B
131
−74.759
−55.671
−30.148
1.00
48.19
C


ATOM
10027
CD1
LEU
B
131
−73.382
−55.852
−29.523
1.00
47.23
C


ATOM
10031
CD2
LEU
B
131
−75.861
−55.670
−29.083
1.00
47.77
C


ATOM
10035
C
LEU
B
131
−75.968
−52.875
−32.604
1.00
48.29
C


ATOM
10036
O
LEU
B
131
−76.022
−51.895
−31.874
1.00
48.44
O


ATOM
10038
N
LYS
B
132
−75.927
−52.771
−33.934
1.00
47.95
N


ATOM
10039
CA
LYS
B
132
−76.020
−51.471
−34.621
1.00
47.64
C


ATOM
10041
CB
LYS
B
132
−75.548
−51.590
−36.080
1.00
47.63
C


ATOM
10044
CG
LYS
B
132
−76.595
−52.235
−36.998
1.00
48.19
C


ATOM
10047
CD
LYS
B
132
−76.111
−52.483
−38.429
1.00
48.16
C


ATOM
10050
CE
LYS
B
132
−77.239
−53.040
−39.290
1.00
47.23
C


ATOM
10053
NZ
LYS
B
132
−76.725
−53.936
−40.331
1.00
47.01
N


ATOM
10057
C
LYS
B
132
−77.449
−50.907
−34.597
1.00
47.13
C


ATOM
10058
O
LYS
B
132
−77.683
−49.772
−35.005
1.00
46.87
O


ATOM
10060
N
GLU
B
133
−78.403
−51.716
−34.149
1.00
46.77
N


ATOM
10061
CA
GLU
B
133
−79.806
−51.315
−34.107
1.00
46.49
C


ATOM
10063
CB
GLU
B
133
−80.691
−52.458
−34.622
1.00
46.56
C


ATOM
10066
CG
GLU
B
133
−80.732
−52.515
−36.155
1.00
47.01
C


ATOM
10069
CD
GLU
B
133
−80.737
−53.926
−36.715
1.00
47.40
C


ATOM
10070
OE1
GLU
B
133
−81.500
−54.775
−36.206
1.00
47.97
O


ATOM
10071
OE2
GLU
B
133
−79.983
−54.177
−37.679
1.00
47.22
O


ATOM
10072
C
GLU
B
133
−80.260
−50.830
−32.723
1.00
45.92
C


ATOM
10073
O
GLU
B
133
−81.369
−50.308
−32.600
1.00
46.14
O


ATOM
10075
N
ASP
B
134
−79.424
−51.002
−31.691
1.00
44.98
N


ATOM
10076
CA
ASP
B
134
−79.611
−50.277
−30.428
1.00
44.14
C


ATOM
10078
CB
ASP
B
134
−79.375
−51.162
−29.197
1.00
43.95
C


ATOM
10081
CG
ASP
B
134
−79.646
−50.419
−27.883
1.00
43.57
C


ATOM
10082
OD1
ASP
B
134
−80.014
−49.230
−27.919
1.00
42.21
O


ATOM
10083
OD2
ASP
B
134
−79.488
−51.011
−26.802
1.00
43.69
O


ATOM
10084
C
ASP
B
134
−78.662
−49.073
−30.426
1.00
43.47
C


ATOM
10085
O
ASP
B
134
−77.478
−49.196
−30.104
1.00
43.55
O


ATOM
10087
N
ILE
B
135
−79.198
−47.908
−30.776
1.00
42.47
N


ATOM
10088
CA
ILE
B
135
−78.375
−46.739
−31.033
1.00
41.65
C


ATOM
10090
CB
ILE
B
135
−79.080
−45.783
−32.012
1.00
41.45
C


ATOM
10092
CG1
ILE
B
135
−78.877
−46.313
−33.434
1.00
41.74
C


ATOM
10095
CD1
ILE
B
135
−79.174
−45.331
−34.540
1.00
42.77
C


ATOM
10099
CG2
ILE
B
135
−78.533
−44.391
−31.905
1.00
41.68
C


ATOM
10103
C
ILE
B
135
−77.901
−46.059
−29.746
1.00
41.14
C


ATOM
10104
O
ILE
B
135
−76.752
−45.624
−29.676
1.00
41.11
O


ATOM
10106
N
LYS
B
136
−78.742
−45.998
−28.714
1.00
40.53
N


ATOM
10107
CA
LYS
B
136
−78.281
−45.480
−27.409
1.00
40.10
C


ATOM
10109
CB
LYS
B
136
−79.431
−45.361
−26.375
1.00
40.40
C


ATOM
10112
CG
LYS
B
136
−79.910
−46.697
−25.786
1.00
42.49
C


ATOM
10115
CD
LYS
B
136
−81.002
−46.574
−24.698
1.00
44.79
C


ATOM
10118
CE
LYS
B
136
−81.599
−47.994
−24.363
1.00
46.03
C


ATOM
10121
NZ
LYS
B
136
−82.231
−48.149
−22.994
1.00
46.23
N


ATOM
10125
C
LYS
B
136
−77.104
−46.327
−26.863
1.00
38.85
C


ATOM
10126
O
LYS
B
136
−76.246
−45.806
−26.143
1.00
38.91
O


ATOM
10128
N
ALA
B
137
−77.062
−47.617
−27.219
1.00
37.27
N


ATOM
10129
CA
ALA
B
137
−75.935
−48.486
−26.864
1.00
35.88
C


ATOM
10131
CB
ALA
B
137
−76.255
−49.952
−27.116
1.00
35.69
C


ATOM
10135
C
ALA
B
137
−74.708
−48.085
−27.645
1.00
34.63
C


ATOM
10136
O
ALA
B
137
−73.647
−47.894
−27.055
1.00
34.70
O


ATOM
10138
N
ILE
B
138
−74.845
−47.946
−28.965
1.00
33.12
N


ATOM
10139
CA
ILE
B
138
−73.693
−47.597
−29.805
1.00
31.97
C


ATOM
10141
CB
ILE
B
138
−74.020
−47.572
−31.296
1.00
31.50
C


ATOM
10143
CG1
ILE
B
138
−74.433
−48.955
−31.774
1.00
31.28
C


ATOM
10146
CD1
ILE
B
138
−73.460
−50.052
−31.417
1.00
30.86
C


ATOM
10150
CG2
ILE
B
138
−72.819
−47.138
−32.073
1.00
30.61
C


ATOM
10154
C
ILE
B
138
−73.124
−46.245
−29.413
1.00
31.57
C


ATOM
10155
O
ILE
B
138
−71.909
−46.090
−29.305
1.00
31.77
O


ATOM
10157
N
LEU
B
139
−73.997
−45.268
−29.192
1.00
30.92
N


ATOM
10158
CA
LEU
B
139
−73.555
−43.962
−28.713
1.00
30.29
C


ATOM
10160
CB
LEU
B
139
−74.732
−43.000
−28.530
1.00
30.13
C


ATOM
10163
CG
LEU
B
139
−74.778
−41.890
−29.574
1.00
29.96
C


ATOM
10165
CD1
LEU
B
139
−73.496
−41.060
−29.508
1.00
28.26
C


ATOM
10169
CD2
LEU
B
139
−76.022
−41.019
−29.397
1.00
29.48
C


ATOM
10173
C
LEU
B
139
−72.835
−44.136
−27.397
1.00
29.95
C


ATOM
10174
O
LEU
B
139
−71.709
−43.687
−27.232
1.00
30.45
O


ATOM
10176
N
SER
B
140
−73.492
−44.807
−26.463
1.00
29.33
N


ATOM
10177
CA
SER
B
140
−72.916
−45.061
−25.150
1.00
28.84
C


ATOM
10179
CB
SER
B
140
−73.900
−45.878
−24.298
1.00
28.93
C


ATOM
10182
OG
SER
B
140
−73.527
−45.870
−22.930
1.00
30.33
O


ATOM
10184
C
SER
B
140
−71.555
−45.770
−25.243
1.00
27.78
C


ATOM
10185
O
SER
B
140
−70.637
−45.454
−24.489
1.00
27.46
O


ATOM
10187
N
LEU
B
141
−71.432
−46.719
−26.167
1.00
26.82
N


ATOM
10188
CA
LEU
B
141
−70.178
−47.433
−26.348
1.00
26.34
C


ATOM
10190
CB
LEU
B
141
−70.366
−48.658
−27.256
1.00
26.16
C


ATOM
10193
CG
LEU
B
141
−69.098
−49.472
−27.584
1.00
26.09
C


ATOM
10195
CD1
LEU
B
141
−68.355
−49.960
−26.330
1.00
24.64
C


ATOM
10199
CD2
LEU
B
141
−69.455
−50.643
−28.481
1.00
25.94
C


ATOM
10203
C
LEU
B
141
−69.124
−46.476
−26.914
1.00
25.89
C


ATOM
10204
O
LEU
B
141
−68.025
−46.346
−26.366
1.00
25.77
O


ATOM
10206
N
TYR
B
142
−69.471
−45.809
−28.008
1.00
25.41
N


ATOM
10207
CA
TYR
B
142
−68.609
−44.804
−28.610
1.00
25.03
C


ATOM
10209
CB
TYR
B
142
−69.399
−43.982
−29.617
1.00
24.80
C


ATOM
10212
CG
TYR
B
142
−68.736
−42.695
−30.043
1.00
24.47
C


ATOM
10213
CD1
TYR
B
142
−67.761
−42.686
−31.029
1.00
24.18
C


ATOM
10215
CE1
TYR
B
142
−67.166
−41.516
−31.438
1.00
24.70
C


ATOM
10217
CZ
TYR
B
142
−67.548
−40.315
−30.871
1.00
25.80
C


ATOM
10218
OH
TYR
B
142
−66.940
−39.129
−31.279
1.00
27.63
O


ATOM
10220
CE2
TYR
B
142
−68.522
−40.299
−29.890
1.00
25.57
C


ATOM
10222
CD2
TYR
B
142
−69.110
−41.485
−29.485
1.00
24.73
C


ATOM
10224
C
TYR
B
142
−68.095
−43.883
−27.537
1.00
25.17
C


ATOM
10225
O
TYR
B
142
−66.886
−43.732
−27.360
1.00
25.40
O


ATOM
10227
N
GLU
B
143
−69.038
−43.293
−26.807
1.00
25.12
N


ATOM
10228
CA
GLU
B
143
−68.744
−42.256
−25.828
1.00
25.10
C


ATOM
10230
CB
GLU
B
143
−70.046
−41.726
−25.226
1.00
25.33
C


ATOM
10233
CG
GLU
B
143
−70.006
−40.244
−24.849
1.00
27.57
C


ATOM
10236
CD
GLU
B
143
−70.321
−39.313
−26.023
1.00
30.43
C


ATOM
10237
OE1
GLU
B
143
−69.343
−38.764
−26.583
1.00
32.89
O


ATOM
10238
OE2
GLU
B
143
−71.526
−39.130
−26.377
1.00
30.86
O


ATOM
10239
C
GLU
B
143
−67.794
−42.746
−24.729
1.00
24.43
C


ATOM
10240
O
GLU
B
143
−67.026
−41.959
−24.179
1.00
24.06
O


ATOM
10242
N
ALA
B
144
−67.840
−44.050
−24.449
1.00
24.01
N


ATOM
10243
CA
ALA
B
144
−67.033
−44.681
−23.399
1.00
23.74
C


ATOM
10245
CB
ALA
B
144
−67.726
−45.943
−22.883
1.00
23.48
C


ATOM
10249
C
ALA
B
144
−65.631
−45.025
−23.864
1.00
23.57
C


ATOM
10250
O
ALA
B
144
−64.720
−45.171
−23.060
1.00
23.69
O


ATOM
10252
N
SER
B
145
−65.455
−45.168
−25.165
1.00
23.45
N


ATOM
10253
CA
SER
B
145
−64.168
−45.568
−25.701
1.00
23.44
C


ATOM
10255
CB
SER
B
145
−64.300
−45.856
−27.214
1.00
23.63
C


ATOM
10258
OG
SER
B
145
−64.822
−44.748
−27.952
1.00
24.24
O


ATOM
10260
C
SER
B
145
−63.065
−44.520
−25.416
1.00
23.24
C


ATOM
10261
O
SER
B
145
−61.877
−44.848
−25.288
1.00
23.25
O


ATOM
10263
N
PHE
B
146
−63.454
−43.257
−25.285
1.00
22.92
N


ATOM
10264
CA
PHE
B
146
−62.464
−42.189
−25.170
1.00
22.35
C


ATOM
10266
CB
PHE
B
146
−63.090
−40.837
−25.478
1.00
22.09
C


ATOM
10269
CG
PHE
B
146
−63.505
−40.717
−26.911
1.00
22.40
C


ATOM
10270
CD1
PHE
B
146
−62.619
−40.229
−27.868
1.00
21.98
C


ATOM
10272
CE1
PHE
B
146
−62.985
−40.156
−29.201
1.00
21.80
C


ATOM
10274
CZ
PHE
B
146
−64.241
−40.579
−29.594
1.00
21.91
C


ATOM
10276
CE2
PHE
B
146
−65.123
−41.098
−28.649
1.00
22.29
C


ATOM
10278
CD2
PHE
B
146
−64.751
−41.170
−27.323
1.00
22.34
C


ATOM
10280
C
PHE
B
146
−61.762
−42.208
−23.837
1.00
21.91
C


ATOM
10281
O
PHE
B
146
−60.669
−41.683
−23.733
1.00
22.30
O


ATOM
10283
N
LEU
B
147
−62.361
−42.864
−22.841
1.00
21.27
N


ATOM
10284
CA
LEU
B
147
−61.727
−43.050
−21.535
1.00
20.49
C


ATOM
10286
CB
LEU
B
147
−62.791
−43.333
−20.478
1.00
20.14
C


ATOM
10289
CG
LEU
B
147
−63.609
−42.109
−20.102
1.00
18.87
C


ATOM
10291
CD1
LEU
B
147
−64.813
−42.020
−20.959
1.00
15.94
C


ATOM
10295
CD2
LEU
B
147
−63.988
−42.189
−18.642
1.00
18.62
C


ATOM
10299
C
LEU
B
147
−60.678
−44.163
−21.498
1.00
20.41
C


ATOM
10300
O
LEU
B
147
−60.243
−44.552
−20.415
1.00
20.44
O


ATOM
10302
N
ALA
B
148
−60.268
−44.664
−22.662
1.00
20.28
N


ATOM
10303
CA
ALA
B
148
−59.330
−45.784
−22.745
1.00
20.33
C


ATOM
10305
CB
ALA
B
148
−59.188
−46.231
−24.194
1.00
20.15
C


ATOM
10309
C
ALA
B
148
−57.952
−45.462
−22.170
1.00
20.54
C


ATOM
10310
O
ALA
B
148
−57.435
−44.366
−22.341
1.00
20.23
O


ATOM
10312
N
LEU
B
149
−57.366
−46.435
−21.486
1.00
21.19
N


ATOM
10313
CA
LEU
B
149
−55.969
−46.354
−21.067
1.00
22.02
C


ATOM
10315
CB
LEU
B
149
−55.768
−47.073
−19.725
1.00
21.90
C


ATOM
10318
CG
LEU
B
149
−56.541
−46.496
−18.523
1.00
21.50
C


ATOM
10320
CD1
LEU
B
149
−55.979
−47.006
−17.223
1.00
20.96
C


ATOM
10324
CD2
LEU
B
149
−56.520
−44.974
−18.505
1.00
20.95
C


ATOM
10328
C
LEU
B
149
−55.054
−46.930
−22.159
1.00
22.84
C


ATOM
10329
O
LEU
B
149
−55.507
−47.678
−23.017
1.00
22.91
O


ATOM
10331
N
GLU
B
150
−53.781
−46.550
−22.163
1.00
23.93
N


ATOM
10332
CA
GLU
B
150
−52.858
−47.071
−23.174
1.00
25.03
C


ATOM
10334
CB
GLU
B
150
−51.472
−46.431
−23.012
1.00
25.41
C


ATOM
10337
CG
GLU
B
150
−50.530
−46.608
−24.213
1.00
27.44
C


ATOM
10340
CD
GLU
B
150
−49.132
−45.987
−23.992
1.00
30.04
C


ATOM
10341
OE1
GLU
B
150
−48.925
−45.330
−22.943
1.00
31.41
O


ATOM
10342
OE2
GLU
B
150
−48.242
−46.161
−24.867
1.00
30.34
O


ATOM
10343
C
GLU
B
150
−52.787
−48.600
−23.024
1.00
25.36
C


ATOM
10344
O
GLU
B
150
−52.613
−49.098
−21.911
1.00
25.58
O


ATOM
10346
N
GLY
B
151
−52.968
−49.337
−24.122
1.00
25.79
N


ATOM
10347
CA
GLY
B
151
−52.959
−50.816
−24.086
1.00
26.11
C


ATOM
10350
C
GLY
B
151
−54.323
−51.522
−24.047
1.00
26.44
C


ATOM
10351
O
GLY
B
151
−54.393
−52.747
−24.135
1.00
26.91
O


ATOM
10353
N
GLU
B
152
−55.407
−50.768
−23.899
1.00
26.58
N


ATOM
10354
CA
GLU
B
152
−56.757
−51.319
−23.971
1.00
26.57
C


ATOM
10356
CB
GLU
B
152
−57.697
−50.531
−23.065
1.00
26.74
C


ATOM
10359
CG
GLU
B
152
−57.291
−50.595
−21.596
1.00
27.63
C


ATOM
10362
CD
GLU
B
152
−58.271
−49.893
−20.668
1.00
28.86
C


ATOM
10363
OE1
GLU
B
152
−58.239
−50.192
−19.449
1.00
28.80
O


ATOM
10364
OE2
GLU
B
152
−59.066
−49.044
−21.154
1.00
29.26
O


ATOM
10365
C
GLU
B
152
−57.254
−51.303
−25.415
1.00
26.53
C


ATOM
10366
O
GLU
B
152
−57.937
−50.381
−25.869
1.00
26.00
O


ATOM
10368
N
ASN
B
153
−56.888
−52.354
−26.127
1.00
26.77
N


ATOM
10369
CA
ASN
B
153
−57.189
−52.498
−27.545
1.00
27.05
C


ATOM
10371
CB
ASN
B
153
−56.345
−53.640
−28.104
1.00
27.12
C


ATOM
10374
CG
ASN
B
153
−56.770
−54.992
−27.549
1.00
27.81
C


ATOM
10375
OD1
ASN
B
153
−56.540
−55.307
−26.379
1.00
27.65
O


ATOM
10376
ND2
ASN
B
153
−57.426
−55.782
−28.382
1.00
29.43
N


ATOM
10379
C
ASN
B
153
−58.659
−52.788
−27.873
1.00
27.09
C


ATOM
10380
O
ASN
B
153
−59.053
−52.658
−29.029
1.00
27.11
O


ATOM
10382
N
ILE
B
154
−59.448
−53.223
−26.884
1.00
27.17
N


ATOM
10383
CA
ILE
B
154
−60.865
−53.544
−27.100
1.00
27.11
C


ATOM
10385
CB
ILE
B
154
−61.454
−54.369
−25.956
1.00
26.99
C


ATOM
10387
CG1
ILE
B
154
−60.811
−55.750
−25.907
1.00
27.16
C


ATOM
10390
CD1
ILE
B
154
−61.309
−56.622
−24.746
1.00
27.41
C


ATOM
10394
CG2
ILE
B
154
−62.953
−54.519
−26.124
1.00
26.65
C


ATOM
10398
C
ILE
B
154
−61.704
−52.284
−27.229
1.00
27.43
C


ATOM
10399
O
ILE
B
154
−62.718
−52.279
−27.939
1.00
27.39
O


ATOM
10401
N
LEU
B
155
−61.296
−51.226
−26.522
1.00
27.76
N


ATOM
10402
CA
LEU
B
155
−61.964
−49.918
−26.609
1.00
27.75
C


ATOM
10404
CB
LEU
B
155
−61.578
−49.024
−25.430
1.00
27.31
C


ATOM
10407
CG
LEU
B
155
−61.968
−49.544
−24.052
1.00
26.64
C


ATOM
10409
CD1
LEU
B
155
−61.444
−48.631
−22.981
1.00
25.82
C


ATOM
10413
CD2
LEU
B
155
−63.465
−49.674
−23.944
1.00
26.45
C


ATOM
10417
C
LEU
B
155
−61.620
−49.226
−27.924
1.00
28.32
C


ATOM
10418
O
LEU
B
155
−62.499
−48.672
−28.583
1.00
28.72
O


ATOM
10420
N
ASP
B
156
−60.348
−49.264
−28.309
1.00
28.84
N


ATOM
10421
CA
ASP
B
156
−59.934
−48.737
−29.601
1.00
29.43
C


ATOM
10423
CB
ASP
B
156
−58.423
−48.928
−29.823
1.00
29.92
C


ATOM
10426
CG
ASP
B
156
−57.566
−47.912
−29.045
1.00
31.35
C


ATOM
10427
OD1
ASP
B
156
−57.803
−46.680
−29.162
1.00
33.23
O


ATOM
10428
OD2
ASP
B
156
−56.640
−48.351
−28.324
1.00
33.08
O


ATOM
10429
C
ASP
B
156
−60.719
−49.411
−30.717
1.00
29.36
C


ATOM
10430
O
ASP
B
156
−61.075
−48.768
−31.697
1.00
29.33
O


ATOM
10432
N
GLU
B
157
−60.981
−50.705
−30.558
1.00
29.63
N


ATOM
10433
CA
GLU
B
157
−61.845
−51.457
−31.479
1.00
29.98
C


ATOM
10435
CB
GLU
B
157
−61.729
−52.971
−31.234
1.00
30.30
C


ATOM
10438
CG
GLU
B
157
−60.664
−53.647
−32.087
1.00
31.79
C


ATOM
10441
CD
GLU
B
157
−60.075
−54.901
−31.439
1.00
33.87
C


ATOM
10442
OE1
GLU
B
157
−60.793
−55.560
−30.640
1.00
35.07
O


ATOM
10443
OE2
GLU
B
157
−58.894
−55.223
−31.743
1.00
33.70
O


ATOM
10444
C
GLU
B
157
−63.304
−51.030
−31.349
1.00
29.53
C


ATOM
10445
O
GLU
B
157
−63.999
−50.878
−32.351
1.00
29.53
O


ATOM
10447
N
ALA
B
158
−63.758
−50.853
−30.112
1.00
29.11
N


ATOM
10448
CA
ALA
B
158
−65.104
−50.370
−29.840
1.00
28.87
C


ATOM
10450
CB
ALA
B
158
−65.307
−50.195
−28.351
1.00
28.82
C


ATOM
10454
C
ALA
B
158
−65.383
−49.065
−30.567
1.00
28.73
C


ATOM
10455
O
ALA
B
158
−66.485
−48.857
−31.065
1.00
28.80
O


ATOM
10457
N
LYS
B
159
−64.385
−48.197
−30.642
1.00
28.65
N


ATOM
10458
CA
LYS
B
159
−64.553
−46.910
−31.296
1.00
28.98
C


ATOM
10460
CB
LYS
B
159
−63.439
−45.950
−30.857
1.00
29.16
C


ATOM
10463
CG
LYS
B
159
−63.558
−44.536
−31.426
1.00
29.82
C


ATOM
10466
CD
LYS
B
159
−62.812
−43.493
−30.592
1.00
30.96
C


ATOM
10469
CE
LYS
B
159
−61.295
−43.610
−30.691
1.00
31.57
C


ATOM
10472
NZ
LYS
B
159
−60.630
−42.426
−30.079
1.00
31.49
N


ATOM
10476
C
LYS
B
159
−64.594
−47.041
−32.826
1.00
29.08
C


ATOM
10477
O
LYS
B
159
−65.385
−46.372
−33.486
1.00
28.73
O


ATOM
10479
N
VAL
B
160
−63.736
−47.891
−33.386
1.00
29.53
N


ATOM
10480
CA
VAL
B
160
−63.686
−48.087
−34.836
1.00
29.89
C


ATOM
10482
CB
VAL
B
160
−62.466
−48.971
−35.282
1.00
29.93
C


ATOM
10484
CG1
VAL
B
160
−62.576
−49.375
−36.756
1.00
29.58
C


ATOM
10488
CG2
VAL
B
160
−61.152
−48.244
−35.040
1.00
29.41
C


ATOM
10492
C
VAL
B
160
−65.001
−48.723
−35.263
1.00
30.32
C


ATOM
10493
O
VAL
B
160
−65.507
−48.459
−36.362
1.00
30.41
O


ATOM
10495
N
PHE
B
161
−65.558
−49.540
−34.371
1.00
30.83
N


ATOM
10496
CA
PHE
B
161
−66.854
−50.178
−34.599
1.00
31.34
C


ATOM
10498
CB
PHE
B
161
−67.090
−51.321
−33.599
1.00
31.34
C


ATOM
10501
CG
PHE
B
161
−68.492
−51.834
−33.603
1.00
31.09
C


ATOM
10502
CD1
PHE
B
161
−68.940
−52.636
−34.633
1.00
31.61
C


ATOM
10504
CE1
PHE
B
161
−70.249
−53.098
−34.649
1.00
31.48
C


ATOM
10506
CZ
PHE
B
161
−71.114
−52.748
−33.628
1.00
30.76
C


ATOM
10508
CE2
PHE
B
161
−70.677
−51.944
−32.606
1.00
30.19
C


ATOM
10510
CD2
PHE
B
161
−69.378
−51.486
−32.597
1.00
30.70
C


ATOM
10512
C
PHE
B
161
−67.992
−49.173
−34.504
1.00
31.65
C


ATOM
10513
O
PHE
B
161
−68.785
−49.038
−35.432
1.00
31.62
O


ATOM
10515
N
ALA
B
162
−68.068
−48.483
−33.373
1.00
32.26
N


ATOM
10516
CA
ALA
B
162
−69.135
−47.519
−33.129
1.00
32.84
C


ATOM
10518
CB
ALA
B
162
−68.948
−46.854
−31.778
1.00
32.66
C


ATOM
10522
C
ALA
B
162
−69.224
−46.474
−34.245
1.00
33.40
C


ATOM
10523
O
ALA
B
162
−70.229
−46.408
−34.937
1.00
33.45
O


ATOM
10525
N
ILE
B
163
−68.164
−45.697
−34.444
1.00
34.38
N


ATOM
10526
CA
ILE
B
163
−68.166
−44.610
−35.439
1.00
35.23
C


ATOM
10528
CB
ILE
B
163
−66.734
−44.062
−35.733
1.00
35.18
C


ATOM
10530
CG1
ILE
B
163
−66.092
−43.457
−34.488
1.00
35.21
C


ATOM
10533
CD1
ILE
B
163
−64.620
−43.171
−34.663
1.00
35.96
C


ATOM
10537
CG2
ILE
B
163
−66.778
−42.977
−36.799
1.00
34.72
C


ATOM
10541
C
ILE
B
163
−68.778
−45.052
−36.766
1.00
36.18
C


ATOM
10542
O
ILE
B
163
−69.588
−44.335
−37.360
1.00
35.87
O


ATOM
10544
N
SER
B
164
−68.379
−46.240
−37.217
1.00
37.67
N


ATOM
10545
CA
SER
B
164
−68.761
−46.752
−38.539
1.00
38.74
C


ATOM
10547
CB
SER
B
164
−68.104
−48.117
−38.815
1.00
38.80
C


ATOM
10550
OG
SER
B
164
−68.733
−49.158
−38.077
1.00
39.07
O


ATOM
10552
C
SER
B
164
−70.277
−46.861
−38.699
1.00
39.51
C


ATOM
10553
O
SER
B
164
−70.820
−46.494
−39.737
1.00
39.96
O


ATOM
10555
N
HIS
B
165
−70.962
−47.363
−37.680
1.00
40.28
N


ATOM
10556
CA
HIS
B
165
−72.410
−47.485
−37.767
1.00
41.07
C


ATOM
10558
CB
HIS
B
165
−72.911
−48.686
−36.957
1.00
41.38
C


ATOM
10561
CG
HIS
B
165
−72.571
−50.005
−37.587
1.00
42.65
C


ATOM
10562
ND1
HIS
B
165
−71.647
−50.875
−37.046
1.00
43.54
N


ATOM
10564
CE1
HIS
B
165
−71.535
−51.938
−37.825
1.00
43.54
C


ATOM
10566
NE2
HIS
B
165
−72.346
−51.785
−38.858
1.00
43.25
N


ATOM
10568
CD2
HIS
B
165
−73.001
−50.582
−38.737
1.00
43.31
C


ATOM
10570
C
HIS
B
165
−73.125
−46.193
−37.380
1.00
41.21
C


ATOM
10571
O
HIS
B
165
−74.257
−45.980
−37.805
1.00
41.53
O


ATOM
10573
N
LEU
B
166
−72.459
−45.326
−36.614
1.00
41.32
N


ATOM
10574
CA
LEU
B
166
−73.042
−44.039
−36.201
1.00
41.31
C


ATOM
10576
CB
LEU
B
166
−72.317
−43.460
−34.973
1.00
41.14
C


ATOM
10579
CG
LEU
B
166
−72.732
−43.975
−33.589
1.00
40.03
C


ATOM
10581
CD1
LEU
B
166
−71.673
−43.634
−32.579
1.00
38.86
C


ATOM
10585
CD2
LEU
B
166
−74.077
−43.421
−33.151
1.00
38.52
C


ATOM
10589
C
LEU
B
166
−73.045
−42.992
−37.313
1.00
41.80
C


ATOM
10590
O
LEU
B
166
−74.006
−42.230
−37.442
1.00
41.73
O


ATOM
10592
N
LYS
B
167
−71.982
−42.947
−38.116
1.00
42.47
N


ATOM
10593
CA
LYS
B
167
−71.847
−41.891
−39.137
1.00
43.00
C


ATOM
10595
CB
LYS
B
167
−70.416
−41.822
−39.702
1.00
43.12
C


ATOM
10598
CG
LYS
B
167
−69.937
−43.068
−40.450
1.00
44.12
C


ATOM
10601
CD
LYS
B
167
−69.138
−42.725
−41.736
1.00
45.36
C


ATOM
10604
CE
LYS
B
167
−67.898
−41.842
−41.483
1.00
45.65
C


ATOM
10607
NZ
LYS
B
167
−67.267
−41.400
−42.762
1.00
44.94
N


ATOM
10611
C
LYS
B
167
−72.873
−41.950
−40.283
1.00
42.99
C


ATOM
10612
O
LYS
B
167
−72.826
−41.124
−41.182
1.00
42.95
O


ATOM
10614
N
GLU
B
168
−73.791
−42.912
−40.244
1.00
43.23
N


ATOM
10615
CA
GLU
B
168
−74.928
−42.940
−41.167
1.00
43.44
C


ATOM
10617
CB
GLU
B
168
−74.652
−43.969
−42.272
1.00
43.58
C


ATOM
10620
CG
GLU
B
168
−73.918
−43.363
−43.501
1.00
44.36
C


ATOM
10623
CD
GLU
B
168
−72.618
−44.082
−43.895
1.00
44.53
C


ATOM
10624
OE1
GLU
B
168
−71.853
−44.494
−42.992
1.00
44.71
O


ATOM
10625
OE2
GLU
B
168
−72.351
−44.197
−45.115
1.00
43.31
O


ATOM
10626
C
GLU
B
168
−76.263
−43.214
−40.442
1.00
43.24
C


ATOM
10627
O
GLU
B
168
−76.932
−42.291
−39.942
1.00
42.54
O


ATOM
10629
N
GLY
B
175
−83.548
−42.037
−36.239
1.00
49.43
N


ATOM
10630
CA
GLY
B
175
−84.473
−41.266
−35.416
1.00
49.54
C


ATOM
10633
C
GLY
B
175
−84.709
−39.884
−36.001
1.00
49.76
C


ATOM
10634
O
GLY
B
175
−84.828
−39.741
−37.220
1.00
49.70
O


ATOM
10636
N
LYS
B
176
−84.766
−38.870
−35.131
1.00
49.95
N


ATOM
10637
CA
LYS
B
176
−85.014
−37.468
−35.534
1.00
50.05
C


ATOM
10639
CB
LYS
B
176
−86.522
−37.225
−35.730
1.00
50.27
C


ATOM
10642
CG
LYS
B
176
−87.301
−36.813
−34.460
1.00
51.33
C


ATOM
10645
CD
LYS
B
176
−88.553
−37.658
−34.202
1.00
52.21
C


ATOM
10648
CE
LYS
B
176
−88.841
−37.754
−32.695
1.00
52.36
C


ATOM
10651
NZ
LYS
B
176
−90.029
−38.607
−32.422
1.00
52.15
N


ATOM
10655
C
LYS
B
176
−84.427
−36.432
−34.554
1.00
49.75
C


ATOM
10656
O
LYS
B
176
−83.990
−35.370
−34.972
1.00
49.88
O


ATOM
10658
N
GLU
B
177
−84.473
−36.729
−33.254
1.00
49.46
N


ATOM
10659
CA
GLU
B
177
−83.769
−35.959
−32.221
1.00
48.92
C


ATOM
10661
CB
GLU
B
177
−84.628
−35.813
−30.946
1.00
49.03
C


ATOM
10664
CG
GLU
B
177
−84.196
−36.691
−29.732
1.00
49.60
C


ATOM
10667
CD
GLU
B
177
−85.278
−36.871
−28.662
1.00
50.10
C


ATOM
10668
OE1
GLU
B
177
−84.998
−37.576
−27.670
1.00
49.78
O


ATOM
10669
OE2
GLU
B
177
−86.401
−36.336
−28.808
1.00
50.78
O


ATOM
10670
C
GLU
B
177
−82.469
−36.703
−31.924
1.00
48.19
C


ATOM
10671
O
GLU
B
177
−81.421
−36.085
−31.721
1.00
48.68
O


ATOM
10673
N
LEU
B
178
−82.557
−38.037
−31.900
1.00
46.98
N


ATOM
10674
CA
LEU
B
178
−81.398
−38.924
−31.817
1.00
45.91
C


ATOM
10676
CB
LEU
B
178
−81.838
−40.387
−31.945
1.00
45.70
C


ATOM
10679
CG
LEU
B
178
−81.111
−41.408
−31.074
1.00
45.24
C


ATOM
10681
CD1
LEU
B
178
−81.498
−41.225
−29.609
1.00
44.88
C


ATOM
10685
CD2
LEU
B
178
−81.413
−42.826
−31.539
1.00
44.19
C


ATOM
10689
C
LEU
B
178
−80.423
−38.571
−32.934
1.00
45.27
C


ATOM
10690
O
LEU
B
178
−79.211
−38.624
−32.759
1.00
44.99
O


ATOM
10692
N
ALA
B
179
−80.970
−38.203
−34.088
1.00
44.75
N


ATOM
10693
CA
ALA
B
179
−80.174
−37.661
−35.181
1.00
44.24
C


ATOM
10695
CB
ALA
B
179
−81.088
−37.069
−36.231
1.00
44.30
C


ATOM
10699
C
ALA
B
179
−79.192
−36.602
−34.683
1.00
43.65
C


ATOM
10700
O
ALA
B
179
−78.028
−36.604
−35.061
1.00
43.56
O


ATOM
10702
N
GLU
B
180
−79.675
−35.707
−33.827
1.00
43.01
N


ATOM
10703
CA
GLU
B
180
−78.863
−34.610
−33.311
1.00
42.49
C


ATOM
10705
CB
GLU
B
180
−79.749
−33.477
−32.789
1.00
42.85
C


ATOM
10708
CG
GLU
B
180
−80.574
−32.800
−33.881
1.00
44.23
C


ATOM
10711
CD
GLU
B
180
−80.991
−31.382
−33.519
1.00
45.80
C


ATOM
10712
OE1
GLU
B
180
−80.098
−30.580
−33.156
1.00
46.69
O


ATOM
10713
OE2
GLU
B
180
−82.203
−31.065
−33.610
1.00
46.71
O


ATOM
10714
C
GLU
B
180
−77.944
−35.075
−32.210
1.00
41.39
C


ATOM
10715
O
GLU
B
180
−76.843
−34.562
−32.071
1.00
41.27
O


ATOM
10717
N
GLN
B
181
−78.404
−36.035
−31.419
1.00
40.20
N


ATOM
10718
CA
GLN
B
181
−77.570
−36.632
−30.394
1.00
39.45
C


ATOM
10720
CB
GLN
B
181
−78.280
−37.809
−29.736
1.00
39.88
C


ATOM
10723
CG
GLN
B
181
−78.005
−37.959
−28.249
1.00
41.64
C


ATOM
10726
CD
GLN
B
181
−78.873
−37.036
−27.404
1.00
44.00
C


ATOM
10727
OE1
GLN
B
181
−80.109
−36.992
−27.581
1.00
45.65
O


ATOM
10728
NE2
GLN
B
181
−78.235
−36.291
−26.474
1.00
43.41
N


ATOM
10731
C
GLN
B
181
−76.270
−37.120
−31.003
1.00
38.28
C


ATOM
10732
O
GLN
B
181
−75.203
−36.767
−30.523
1.00
38.27
O


ATOM
10734
N
VAL
B
182
−76.358
−37.911
−32.072
1.00
37.05
N


ATOM
10735
CA
VAL
B
182
−75.160
−38.515
−32.675
1.00
36.20
C


ATOM
10737
CB
VAL
B
182
−75.486
−39.661
−33.681
1.00
36.11
C


ATOM
10739
CG1
VAL
B
182
−76.493
−40.641
−33.080
1.00
36.13
C


ATOM
10743
CG2
VAL
B
182
−75.977
−39.106
−35.004
1.00
36.06
C


ATOM
10747
C
VAL
B
182
−74.238
−37.495
−33.364
1.00
35.44
C


ATOM
10748
O
VAL
B
182
−73.012
−37.682
−33.375
1.00
35.19
O


ATOM
10750
N
SER
B
183
−74.811
−36.432
−33.936
1.00
34.41
N


ATOM
10751
CA
SER
B
183
−73.998
−35.416
−34.630
1.00
33.74
C


ATOM
10753
CB
SER
B
183
−74.858
−34.438
−35.422
1.00
33.58
C


ATOM
10756
OG
SER
B
183
−76.003
−35.085
−35.925
1.00
34.52
O


ATOM
10758
C
SER
B
183
−73.184
−34.644
−33.625
1.00
32.88
C


ATOM
10759
O
SER
B
183
−72.055
−34.251
−33.906
1.00
33.25
O


ATOM
10761
N
HIS
B
184
−73.788
−34.427
−32.461
1.00
31.83
N


ATOM
10762
CA
HIS
B
184
−73.150
−33.787
−31.326
1.00
30.98
C


ATOM
10764
CB
HIS
B
184
−74.188
−33.627
−30.212
1.00
31.14
C


ATOM
10767
CG
HIS
B
184
−73.710
−32.849
−29.030
1.00
31.91
C


ATOM
10768
ND1
HIS
B
184
−73.326
−31.527
−29.114
1.00
33.18
N


ATOM
10770
CE1
HIS
B
184
−72.960
−31.107
−27.914
1.00
33.10
C


ATOM
10772
NE2
HIS
B
184
−73.106
−32.102
−27.056
1.00
31.85
N


ATOM
10774
CD2
HIS
B
184
−73.583
−33.200
−27.727
1.00
31.86
C


ATOM
10776
C
HIS
B
184
−71.968
−34.632
−30.865
1.00
30.13
C


ATOM
10777
O
HIS
B
184
−70.863
−34.122
−30.709
1.00
29.95
O


ATOM
10779
N
ALA
B
185
−72.194
−35.931
−30.683
1.00
29.27
N


ATOM
10780
CA
ALA
B
185
−71.123
−36.856
−30.281
1.00
28.64
C


ATOM
10782
CB
ALA
B
185
−71.689
−38.233
−29.986
1.00
28.44
C


ATOM
10786
C
ALA
B
185
−70.017
−36.965
−31.330
1.00
28.08
C


ATOM
10787
O
ALA
B
185
−68.839
−37.043
−30.992
1.00
28.26
O


ATOM
10789
N
LEU
B
186
−70.394
−36.984
−32.602
1.00
27.40
N


ATOM
10790
CA
LEU
B
186
−69.412
−37.101
−33.674
1.00
26.84
C


ATOM
10792
CB
LEU
B
186
−70.088
−37.481
−35.000
1.00
26.75
C


ATOM
10795
CG
LEU
B
186
−70.085
−38.983
−35.320
1.00
26.70
C


ATOM
10797
CD1
LEU
B
186
−70.214
−39.868
−34.075
1.00
27.07
C


ATOM
10801
CD2
LEU
B
186
−71.179
−39.306
−36.303
1.00
26.29
C


ATOM
10805
C
LEU
B
186
−68.594
−35.822
−33.815
1.00
26.45
C


ATOM
10806
O
LEU
B
186
−67.449
−35.875
−34.237
1.00
26.48
O


ATOM
10808
N
GLU
B
187
−69.186
−34.685
−33.454
1.00
25.93
N


ATOM
10809
CA
GLU
B
187
−68.479
−33.406
−33.403
1.00
25.57
C


ATOM
10811
CB
GLU
B
187
−69.447
−32.310
−32.962
1.00
25.61
C


ATOM
10814
CG
GLU
B
187
−69.035
−30.899
−33.325
1.00
26.29
C


ATOM
10817
CD
GLU
B
187
−69.930
−29.857
−32.671
1.00
27.10
C


ATOM
10818
OE1
GLU
B
187
−70.312
−30.057
−31.487
1.00
26.51
O


ATOM
10819
OE2
GLU
B
187
−70.251
−28.846
−33.344
1.00
27.54
O


ATOM
10820
C
GLU
B
187
−67.307
−33.490
−32.418
1.00
25.13
C


ATOM
10821
O
GLU
B
187
−66.155
−33.165
−32.749
1.00
24.85
O


ATOM
10823
N
LEU
B
188
−67.625
−33.938
−31.204
1.00
24.58
N


ATOM
10824
CA
LEU
B
188
−66.644
−34.137
−30.148
1.00
24.06
C


ATOM
10826
CB
LEU
B
188
−66.343
−32.817
−29.451
1.00
24.12
C


ATOM
10829
CG
LEU
B
188
−65.042
−32.714
−28.670
1.00
23.61
C


ATOM
10831
CD1
LEU
B
188
−63.895
−32.872
−29.629
1.00
23.12
C


ATOM
10835
CD2
LEU
B
188
−64.976
−31.368
−27.964
1.00
23.18
C


ATOM
10839
C
LEU
B
188
−67.248
−35.087
−29.140
1.00
23.70
C


ATOM
10840
O
LEU
B
188
−68.392
−34.901
−28.743
1.00
23.68
O


ATOM
10842
N
PRO
B
189
−66.493
−36.106
−28.713
1.00
23.34
N


ATOM
10843
CA
PRO
B
189
−67.031
−36.983
−27.692
1.00
23.08
C


ATOM
10845
CB
PRO
B
189
−66.018
−38.115
−27.638
1.00
22.96
C


ATOM
10848
CG
PRO
B
189
−64.743
−37.452
−27.940
1.00
23.22
C


ATOM
10851
CD
PRO
B
189
−65.059
−36.350
−28.929
1.00
23.54
C


ATOM
10854
C
PRO
B
189
−67.053
−36.229
−26.387
1.00
22.86
C


ATOM
10855
O
PRO
B
189
−66.284
−35.285
−26.215
1.00
23.03
O


ATOM
10856
N
LEU
B
190
−67.912
−36.628
−25.465
1.00
22.56
N


ATOM
10857
CA
LEU
B
190
−68.152
−35.773
−24.323
1.00
22.41
C


ATOM
10859
CB
LEU
B
190
−69.567
−35.970
−23.766
1.00
23.04
C


ATOM
10862
CG
LEU
B
190
−69.853
−37.136
−22.848
1.00
23.41
C


ATOM
10864
CD1
LEU
B
190
−69.303
−36.733
−21.481
1.00
25.02
C


ATOM
10868
CD2
LEU
B
190
−71.342
−37.411
−22.820
1.00
21.69
C


ATOM
10872
C
LEU
B
190
−67.065
−35.899
−23.266
1.00
21.56
C


ATOM
10873
O
LEU
B
190
−66.860
−34.976
−22.477
1.00
21.67
O


ATOM
10875
N
HIS
B
191
−66.320
−36.998
−23.283
1.00
20.39
N


ATOM
10876
CA
HIS
B
191
−65.089
−37.037
−22.490
1.00
19.40
C


ATOM
10878
CB
HIS
B
191
−64.399
−38.393
−22.597
1.00
19.19
C


ATOM
10881
CG
HIS
B
191
−63.222
−38.530
−21.689
1.00
19.32
C


ATOM
10882
ND1
HIS
B
191
−63.347
−38.562
−20.317
1.00
20.95
N


ATOM
10884
CE1
HIS
B
191
−62.145
−38.659
−19.771
1.00
21.15
C


ATOM
10886
NE2
HIS
B
191
−61.245
−38.689
−20.741
1.00
19.36
N


ATOM
10888
CD2
HIS
B
191
−61.893
−38.604
−21.948
1.00
19.49
C


ATOM
10890
C
HIS
B
191
−64.094
−35.913
−22.841
1.00
18.62
C


ATOM
10891
O
HIS
B
191
−63.150
−35.677
−22.085
1.00
18.59
O


ATOM
10893
N
ARG
B
192
−64.307
−35.216
−23.957
1.00
17.72
N


ATOM
10894
CA
ARG
B
192
−63.394
−34.150
−24.394
1.00
17.57
C


ATOM
10896
CB
ARG
B
192
−62.838
−34.504
−25.773
1.00
17.81
C


ATOM
10899
CG
ARG
B
192
−61.971
−35.736
−25.781
1.00
18.59
C


ATOM
10902
CD
ARG
B
192
−61.484
−36.067
−27.181
1.00
20.10
C


ATOM
10905
NE
ARG
B
192
−60.462
−37.116
−27.165
1.00
21.62
N


ATOM
10907
CZ
ARG
B
192
−59.919
−37.648
−28.254
1.00
22.77
C


ATOM
10908
NH1
ARG
B
192
−60.304
−37.248
−29.454
1.00
24.20
N


ATOM
10911
NH2
ARG
B
192
−58.987
−38.581
−28.149
1.00
23.37
N


ATOM
10914
C
ARG
B
192
−63.983
−32.726
−24.440
1.00
17.01
C


ATOM
10915
O
ARG
B
192
−63.242
−31.739
−24.526
1.00
15.78
O


ATOM
10917
N
ARG
B
193
−65.309
−32.634
−24.392
1.00
17.01
N


ATOM
10918
CA
ARG
B
193
−66.015
−31.350
−24.453
1.00
16.99
C


ATOM
10920
CB
ARG
B
193
−67.476
−31.582
−24.892
1.00
17.29
C


ATOM
10923
CG
ARG
B
193
−68.192
−30.318
−25.377
1.00
18.42
C


ATOM
10926
CD
ARG
B
193
−69.664
−30.559
−25.646
1.00
19.63
C


ATOM
10929
NE
ARG
B
193
−69.912
−31.592
−26.648
1.00
21.16
N


ATOM
10931
CZ
ARG
B
193
−69.868
−31.398
−27.971
1.00
23.56
C


ATOM
10932
NH1
ARG
B
193
−69.575
−30.210
−28.496
1.00
23.37
N


ATOM
10935
NH2
ARG
B
193
−70.112
−32.413
−28.789
1.00
25.37
N


ATOM
10938
C
ARG
B
193
−65.974
−30.658
−23.087
1.00
16.46
C


ATOM
10939
O
ARG
B
193
−66.040
−31.323
−22.034
1.00
16.47
O


ATOM
10941
N
THR
B
194
−65.864
−29.335
−23.078
1.00
15.84
N


ATOM
10942
CA
THR
B
194
−65.886
−28.629
−21.799
1.00
15.67
C


ATOM
10944
CB
THR
B
194
−65.354
−27.199
−21.884
1.00
15.48
C


ATOM
10946
OG1
THR
B
194
−66.077
−26.478
−22.882
1.00
15.55
O


ATOM
10948
CG2
THR
B
194
−63.877
−27.189
−22.211
1.00
14.65
C


ATOM
10952
C
THR
B
194
−67.310
−28.613
−21.270
1.00
15.79
C


ATOM
10953
O
THR
B
194
−68.264
−28.652
−22.030
1.00
15.73
O


ATOM
10955
N
GLN
B
195
−67.444
−28.557
−19.957
1.00
16.20
N


ATOM
10956
CA
GLN
B
195
−68.737
−28.711
−19.328
1.00
16.84
C


ATOM
10958
CB
GLN
B
195
−68.601
−28.781
−17.816
1.00
17.07
C


ATOM
10961
CG
GLN
B
195
−69.921
−28.440
−17.153
1.00
18.86
C


ATOM
10964
CD
GLN
B
195
−69.999
−28.875
−15.746
1.00
20.95
C


ATOM
10965
OE1
GLN
B
195
−69.099
−29.511
−15.245
1.00
24.63
O


ATOM
10966
NE2
GLN
B
195
−71.071
−28.529
−15.082
1.00
22.36
N


ATOM
10969
C
GLN
B
195
−69.757
−27.623
−19.669
1.00
16.93
C


ATOM
10970
O
GLN
B
195
−70.858
−27.931
−20.136
1.00
16.98
O


ATOM
10972
N
ARG
B
196
−69.430
−26.366
−19.386
1.00
16.92
N


ATOM
10973
CA
ARG
B
196
−70.358
−25.301
−19.685
1.00
17.06
C


ATOM
10975
CB
ARG
B
196
−69.719
−23.932
−19.459
1.00
17.00
C


ATOM
10978
CG
ARG
B
196
−70.095
−23.289
−18.120
1.00
17.09
C


ATOM
10981
CD
ARG
B
196
−70.283
−24.320
−16.995
1.00
17.56
C


ATOM
10984
NE
ARG
B
196
−71.452
−24.043
−16.146
1.00
17.64
N


ATOM
10986
CZ
ARG
B
196
−72.289
−24.965
−15.664
1.00
17.93
C


ATOM
10987
NH1
ARG
B
196
−72.136
−26.244
−15.966
1.00
17.72
N


ATOM
10990
NH2
ARG
B
196
−73.305
−24.611
−14.878
1.00
18.27
N


ATOM
10993
C
ARG
B
196
−70.881
−25.481
−21.098
1.00
17.42
C


ATOM
10994
O
ARG
B
196
−72.079
−25.519
−21.317
1.00
17.66
O


ATOM
10996
N
LEU
B
197
−69.984
−25.676
−22.044
1.00
18.04
N


ATOM
10997
CA
LEU
B
197
−70.379
−25.925
−23.425
1.00
18.51
C


ATOM
10999
CB
LEU
B
197
−69.133
−26.085
−24.289
1.00
18.52
C


ATOM
11002
CG
LEU
B
197
−68.998
−25.185
−25.508
1.00
18.06
C


ATOM
11004
CD1
LEU
B
197
−68.209
−23.932
−25.205
1.00
15.52
C


ATOM
11008
CD2
LEU
B
197
−68.293
−26.002
−26.574
1.00
20.21
C


ATOM
11012
C
LEU
B
197
−71.290
−27.163
−23.580
1.00
19.14
C


ATOM
11013
O
LEU
B
197
−72.226
−27.150
−24.372
1.00
19.52
O


ATOM
11015
N
GLU
B
198
−71.030
−28.235
−22.842
1.00
19.72
N


ATOM
11016
CA
GLU
B
198
−71.918
−29.396
−22.909
1.00
20.43
C


ATOM
11018
CB
GLU
B
198
−71.272
−30.631
−22.270
1.00
20.65
C


ATOM
11021
CG
GLU
B
198
−72.176
−31.880
−22.172
1.00
22.51
C


ATOM
11024
CD
GLU
B
198
−72.635
−32.460
−23.522
1.00
25.57
C


ATOM
11025
OE1
GLU
B
198
−72.315
−31.896
−24.581
1.00
28.90
O


ATOM
11026
OE2
GLU
B
198
−73.326
−33.506
−23.540
1.00
28.09
O


ATOM
11027
C
GLU
B
198
−73.271
−29.101
−22.259
1.00
20.72
C


ATOM
11028
O
GLU
B
198
−74.281
−29.693
−22.644
1.00
20.82
O


ATOM
11030
N
ALA
B
199
−73.282
−28.199
−21.270
1.00
20.86
N


ATOM
11031
CA
ALA
B
199
−74.508
−27.814
−20.565
1.00
20.66
C


ATOM
11033
CB
ALA
B
199
−74.176
−27.013
−19.326
1.00
20.36
C


ATOM
11037
C
ALA
B
199
−75.472
−27.033
−21.461
1.00
20.84
C


ATOM
11038
O
ALA
B
199
−76.644
−27.404
−21.590
1.00
20.84
O


ATOM
11040
N
VAL
B
200
−75.002
−25.961
−22.092
1.00
21.12
N


ATOM
11041
CA
VAL
B
200
−75.903
−25.177
−22.942
1.00
21.60
C


ATOM
11043
CB
VAL
B
200
−75.215
−24.042
−23.701
1.00
21.30
C


ATOM
11045
CG1
VAL
B
200
−74.660
−23.055
−22.738
1.00
21.26
C


ATOM
11049
CG2
VAL
B
200
−74.135
−24.575
−24.626
1.00
21.28
C


ATOM
11053
C
VAL
B
200
−76.603
−26.077
−23.944
1.00
22.32
C


ATOM
11054
O
VAL
B
200
−77.791
−25.908
−24.218
1.00
22.32
O


ATOM
11056
N
TRP
B
201
−75.872
−27.047
−24.472
1.00
23.16
N


ATOM
11057
CA
TRP
B
201
−76.441
−27.946
−25.454
1.00
24.02
C


ATOM
11059
CB
TRP
B
201
−75.348
−28.718
−26.195
1.00
24.36
C


ATOM
11062
CG
TRP
B
201
−75.898
−29.510
−27.331
1.00
24.84
C


ATOM
11063
CD1
TRP
B
201
−76.060
−29.092
−28.613
1.00
25.41
C


ATOM
11065
NE1
TRP
B
201
−76.599
−30.094
−29.374
1.00
25.61
N


ATOM
11067
CE2
TRP
B
201
−76.807
−31.184
−28.579
1.00
25.34
C


ATOM
11068
CD2
TRP
B
201
−76.374
−30.847
−27.279
1.00
25.56
C


ATOM
11069
CE3
TRP
B
201
−76.466
−31.800
−26.264
1.00
27.13
C


ATOM
11071
CZ3
TRP
B
201
−76.989
−33.046
−26.574
1.00
28.66
C


ATOM
11073
CH2
TRP
B
201
−77.419
−33.347
−27.885
1.00
28.01
C


ATOM
11075
CZ2
TRP
B
201
−77.332
−32.425
−28.894
1.00
26.09
C


ATOM
11077
C
TRP
B
201
−77.411
−28.938
−24.833
1.00
24.22
C


ATOM
11078
O
TRP
B
201
−78.473
−29.172
−25.383
1.00
24.83
O


ATOM
11080
N
SER
B
202
−77.034
−29.541
−23.715
1.00
24.39
N


ATOM
11081
CA
SER
B
202
−77.818
−30.626
−23.144
1.00
24.50
C


ATOM
11083
CB
SER
B
202
−76.968
−31.455
−22.184
1.00
24.42
C


ATOM
11086
OG
SER
B
202
−75.848
−32.021
−22.848
1.00
23.80
O


ATOM
11088
C
SER
B
202
−79.067
−30.099
−22.441
1.00
24.98
C


ATOM
11089
O
SER
B
202
−80.057
−30.816
−22.324
1.00
24.73
O


ATOM
11091
N
ILE
B
203
−79.032
−28.849
−21.982
1.00
25.60
N


ATOM
11092
CA
ILE
B
203
−80.219
−28.255
−21.372
1.00
25.98
C


ATOM
11094
CB
ILE
B
203
−79.908
−26.967
−20.591
1.00
25.85
C


ATOM
11096
CG1
ILE
B
203
−79.086
−27.326
−19.348
1.00
25.76
C


ATOM
11099
CD1
ILE
B
203
−78.779
−26.159
−18.431
1.00
26.28
C


ATOM
11103
CG2
ILE
B
203
−81.212
−26.253
−20.206
1.00
24.51
C


ATOM
11107
C
ILE
B
203
−81.280
−28.016
−22.443
1.00
26.67
C


ATOM
11108
O
ILE
B
203
−82.428
−28.398
−22.260
1.00
26.96
O


ATOM
11110
N
GLU
B
204
−80.879
−27.412
−23.563
1.00
27.30
N


ATOM
11111
CA
GLU
B
204
−81.758
−27.205
−24.720
1.00
27.49
C


ATOM
11113
CB
GLU
B
204
−81.036
−26.384
−25.804
1.00
27.67
C


ATOM
11116
CG
GLU
B
204
−81.849
−26.077
−27.073
1.00
28.50
C


ATOM
11119
CD
GLU
B
204
−82.987
−25.072
−26.855
1.00
29.81
C


ATOM
11120
OE1
GLU
B
204
−83.158
−24.600
−25.711
1.00
31.40
O


ATOM
11121
OE2
GLU
B
204
−83.710
−24.750
−27.832
1.00
29.57
O


ATOM
11122
C
GLU
B
204
−82.201
−28.542
−25.287
1.00
27.52
C


ATOM
11123
O
GLU
B
204
−83.321
−28.667
−25.738
1.00
27.67
O


ATOM
11125
N
ALA
B
205
−81.326
−29.539
−25.266
1.00
27.74
N


ATOM
11126
CA
ALA
B
205
−81.684
−30.872
−25.728
1.00
28.09
C


ATOM
11128
CB
ALA
B
205
−80.472
−31.789
−25.726
1.00
27.75
C


ATOM
11132
C
ALA
B
205
−82.771
−31.448
−24.839
1.00
28.81
C


ATOM
11133
O
ALA
B
205
−83.811
−31.877
−25.325
1.00
28.90
O


ATOM
11135
N
TYR
B
206
−82.517
−31.433
−23.531
1.00
29.72
N


ATOM
11136
CA
TYR
B
206
−83.408
−32.020
−22.527
1.00
30.30
C


ATOM
11138
CB
TYR
B
206
−82.760
−31.915
−21.149
1.00
30.24
C


ATOM
11141
CG
TYR
B
206
−83.276
−32.889
−20.127
1.00
29.79
C


ATOM
11142
CD1
TYR
B
206
−83.055
−34.245
−20.286
1.00
30.71
C


ATOM
11144
CE1
TYR
B
206
−83.498
−35.161
−19.360
1.00
30.78
C


ATOM
11146
CZ
TYR
B
206
−84.159
−34.731
−18.238
1.00
30.03
C


ATOM
11147
OH
TYR
B
206
−84.582
−35.684
−17.343
1.00
30.51
O


ATOM
11149
CE2
TYR
B
206
−84.394
−33.379
−18.042
1.00
29.42
C


ATOM
11151
CD2
TYR
B
206
−83.945
−32.463
−18.989
1.00
29.05
C


ATOM
11153
C
TYR
B
206
−84.744
−31.308
−22.467
1.00
31.19
C


ATOM
11154
O
TYR
B
206
−85.790
−31.930
−22.311
1.00
31.44
O


ATOM
11156
N
ARG
B
207
−84.683
−29.988
−22.558
1.00
32.21
N


ATOM
11157
CA
ARG
B
207
−85.853
−29.128
−22.521
1.00
33.04
C


ATOM
11159
CB
ARG
B
207
−85.394
−27.700
−22.843
1.00
32.86
C


ATOM
11162
CG
ARG
B
207
−86.441
−26.637
−22.846
1.00
32.82
C


ATOM
11165
CD
ARG
B
207
−85.905
−25.360
−23.462
1.00
32.76
C


ATOM
11168
NE
ARG
B
207
−85.148
−24.561
−22.504
1.00
32.80
N


ATOM
11170
CZ
ARG
B
207
−85.676
−23.709
−21.628
1.00
33.40
C


ATOM
11171
NH1
ARG
B
207
−86.989
−23.526
−21.555
1.00
34.29
N


ATOM
11174
NH2
ARG
B
207
−84.884
−23.030
−20.808
1.00
33.89
N


ATOM
11177
C
ARG
B
207
−86.971
−29.606
−23.478
1.00
34.14
C


ATOM
11178
O
ARG
B
207
−88.144
−29.521
−23.128
1.00
34.34
O


ATOM
11180
N
LYS
B
208
−86.607
−30.137
−24.652
1.00
35.32
N


ATOM
11181
CA
LYS
B
208
−87.581
−30.535
−25.688
1.00
36.16
C


ATOM
11183
CB
LYS
B
208
−86.960
−30.468
−27.090
1.00
36.01
C


ATOM
11186
CG
LYS
B
208
−86.126
−29.234
−27.368
1.00
35.85
C


ATOM
11189
CD
LYS
B
208
−85.934
−29.023
−28.861
1.00
35.98
C


ATOM
11192
CE
LYS
B
208
−84.774
−28.086
−29.186
1.00
35.63
C


ATOM
11195
NZ
LYS
B
208
−83.566
−28.843
−29.596
1.00
35.17
N


ATOM
11199
C
LYS
B
208
−88.166
−31.937
−25.490
1.00
37.25
C


ATOM
11200
O
LYS
B
208
−89.212
−32.250
−26.054
1.00
37.50
O


ATOM
11202
N
LYS
B
209
−87.484
−32.788
−24.730
1.00
38.58
N


ATOM
11203
CA
LYS
B
209
−88.026
−34.106
−24.383
1.00
39.89
C


ATOM
11205
CB
LYS
B
209
−87.013
−34.923
−23.578
1.00
40.23
C


ATOM
11208
CG
LYS
B
209
−85.914
−35.604
−24.373
1.00
41.47
C


ATOM
11211
CD
LYS
B
209
−84.858
−36.178
−23.417
1.00
43.71
C


ATOM
11214
CE
LYS
B
209
−84.448
−37.612
−23.764
1.00
45.15
C


ATOM
11217
NZ
LYS
B
209
−85.390
−38.621
−23.163
1.00
45.73
N


ATOM
11221
C
LYS
B
209
−89.288
−33.950
−23.530
1.00
40.51
C


ATOM
11222
O
LYS
B
209
−89.230
−33.367
−22.441
1.00
40.84
O


ATOM
11224
N
GLU
B
210
−90.418
−34.477
−24.000
1.00
40.92
N


ATOM
11225
CA
GLU
B
210
−91.652
−34.386
−23.223
1.00
41.27
C


ATOM
11227
CB
GLU
B
210
−92.855
−34.935
−23.998
1.00
41.77
C


ATOM
11230
CG
GLU
B
210
−92.822
−36.446
−24.265
1.00
43.47
C


ATOM
11233
CD
GLU
B
210
−94.049
−36.922
−25.032
1.00
45.23
C


ATOM
11234
OE1
GLU
B
210
−95.188
−36.590
−24.612
1.00
45.02
O


ATOM
11235
OE2
GLU
B
210
−93.863
−37.629
−26.053
1.00
46.74
O


ATOM
11236
C
GLU
B
210
−91.494
−35.121
−21.895
1.00
40.71
C


ATOM
11237
O
GLU
B
210
−91.996
−34.667
−20.864
1.00
40.99
O


ATOM
11239
N
ASP
B
211
−90.773
−36.240
−21.924
1.00
39.76
N


ATOM
11240
CA
ASP
B
211
−90.533
−37.050
−20.721
1.00
38.96
C


ATOM
11242
CB
ASP
B
211
−90.151
−38.476
−21.123
1.00
39.10
C


ATOM
11245
CG
ASP
B
211
−89.101
−38.499
−22.212
1.00
40.26
C


ATOM
11246
OD1
ASP
B
211
−89.327
−37.827
−23.254
1.00
41.25
O


ATOM
11247
OD2
ASP
B
211
−88.055
−39.160
−22.020
1.00
41.66
O


ATOM
11248
C
ASP
B
211
−89.440
−36.468
−19.826
1.00
37.75
C


ATOM
11249
O
ASP
B
211
−89.009
−37.131
−18.892
1.00
37.62
O


ATOM
11251
N
ALA
B
212
−88.989
−35.245
−20.115
1.00
36.47
N


ATOM
11252
CA
ALA
B
212
−87.941
−34.587
−19.335
1.00
35.36
C


ATOM
11254
CB
ALA
B
212
−87.516
−33.294
−20.011
1.00
35.23
C


ATOM
11258
C
ALA
B
212
−88.423
−34.307
−17.920
1.00
34.40
C


ATOM
11259
O
ALA
B
212
−89.559
−33.870
−17.728
1.00
34.42
O


ATOM
11261
N
ASN
B
213
−87.565
−34.574
−16.937
1.00
33.24
N


ATOM
11262
CA
ASN
B
213
−87.890
−34.333
−15.533
1.00
32.67
C


ATOM
11264
CB
ASN
B
213
−86.840
−34.986
−14.623
1.00
32.58
C


ATOM
11267
CG
ASN
B
213
−87.204
−34.912
−13.152
1.00
32.67
C


ATOM
11268
OD1
ASN
B
213
−87.891
−33.994
−12.722
1.00
32.62
O


ATOM
11269
ND2
ASN
B
213
−86.734
−35.882
−12.371
1.00
33.18
N


ATOM
11272
C
ASN
B
213
−87.990
−32.825
−15.266
1.00
32.19
C


ATOM
11273
O
ASN
B
213
−87.010
−32.092
−15.376
1.00
32.38
O


ATOM
11275
N
GLN
B
214
−89.182
−32.356
−14.923
1.00
31.48
N


ATOM
11276
CA
GLN
B
214
−89.389
−30.924
−14.756
1.00
30.85
C


ATOM
11278
CB
GLN
B
214
−90.889
−30.581
−14.693
1.00
30.82
C


ATOM
11281
CG
GLN
B
214
−91.684
−30.869
−16.002
1.00
30.80
C


ATOM
11284
CD
GLN
B
214
−90.990
−30.378
−17.291
1.00
29.69
C


ATOM
11285
OE1
GLN
B
214
−90.893
−29.174
−17.543
1.00
29.07
O


ATOM
11286
NE2
GLN
B
214
−90.526
−31.321
−18.113
1.00
27.71
N


ATOM
11289
C
GLN
B
214
−88.638
−30.369
−13.543
1.00
30.37
C


ATOM
11290
O
GLN
B
214
−88.263
−29.200
−13.533
1.00
30.80
O


ATOM
11292
N
VAL
B
215
−88.393
−31.200
−12.532
1.00
29.54
N


ATOM
11293
CA
VAL
B
215
−87.566
−30.779
−11.395
1.00
28.56
C


ATOM
11295
CB
VAL
B
215
−87.564
−31.818
−10.260
1.00
28.64
C


ATOM
11297
CG1
VAL
B
215
−86.758
−31.299
−9.075
1.00
27.94
C


ATOM
11301
CG2
VAL
B
215
−88.999
−32.167
−9.856
1.00
28.26
C


ATOM
11305
C
VAL
B
215
−86.124
−30.545
−11.845
1.00
27.63
C


ATOM
11306
O
VAL
B
215
−85.566
−29.472
−11.615
1.00
27.58
O


ATOM
11308
N
LEU
B
216
−85.546
−31.548
−12.504
1.00
26.37
N


ATOM
11309
CA
LEU
B
216
−84.143
−31.509
−12.930
1.00
25.47
C


ATOM
11311
CB
LEU
B
216
−83.714
−32.866
−13.490
1.00
25.46
C


ATOM
11314
CG
LEU
B
216
−82.274
−32.995
−13.979
1.00
24.97
C


ATOM
11316
CD1
LEU
B
216
−81.289
−32.640
−12.883
1.00
24.62
C


ATOM
11320
CD2
LEU
B
216
−82.042
−34.407
−14.472
1.00
24.55
C


ATOM
11324
C
LEU
B
216
−83.861
−30.447
−13.972
1.00
24.68
C


ATOM
11325
O
LEU
B
216
−82.819
−29.820
−13.929
1.00
24.91
O


ATOM
11327
N
LEU
B
217
−84.776
−30.269
−14.916
1.00
23.79
N


ATOM
11328
CA
LEU
B
217
−84.625
−29.260
−15.960
1.00
23.13
C


ATOM
11330
CB
LEU
B
217
−85.765
−29.384
−16.972
1.00
23.36
C


ATOM
11333
CG
LEU
B
217
−85.808
−28.374
−18.123
1.00
23.18
C


ATOM
11335
CD1
LEU
B
217
−84.462
−28.268
−18.796
1.00
22.69
C


ATOM
11339
CD2
LEU
B
217
−86.861
−28.786
−19.126
1.00
23.38
C


ATOM
11343
C
LEU
B
217
−84.631
−27.853
−15.383
1.00
22.51
C


ATOM
11344
O
LEU
B
217
−83.903
−26.973
−15.855
1.00
22.08
O


ATOM
11346
N
GLU
B
218
−85.481
−27.647
−14.375
1.00
21.84
N


ATOM
11347
CA
GLU
B
218
−85.619
−26.339
−13.725
1.00
21.26
C


ATOM
11349
CB
GLU
B
218
−86.813
−26.341
−12.768
1.00
21.27
C


ATOM
11352
CG
GLU
B
218
−87.206
−24.956
−12.246
1.00
21.35
C


ATOM
11355
CD
GLU
B
218
−88.501
−24.964
−11.441
1.00
20.89
C


ATOM
11356
OE1
GLU
B
218
−89.097
−26.052
−11.263
1.00
20.47
O


ATOM
11357
OE2
GLU
B
218
−88.915
−23.874
−10.986
1.00
20.15
O


ATOM
11358
C
GLU
B
218
−84.348
−26.001
−12.969
1.00
20.58
C


ATOM
11359
O
GLU
B
218
−83.877
−24.865
−12.982
1.00
20.31
O


ATOM
11361
N
LEU
B
219
−83.802
−27.015
−12.312
1.00
19.87
N


ATOM
11362
CA
LEU
B
219
−82.559
−26.885
−11.592
1.00
19.12
C


ATOM
11364
CB
LEU
B
219
−82.310
−28.132
−10.746
1.00
18.58
C


ATOM
11367
CG
LEU
B
219
−81.159
−28.054
−9.762
1.00
17.07
C


ATOM
11369
CD1
LEU
B
219
−81.321
−26.847
−8.872
1.00
16.10
C


ATOM
11373
CD2
LEU
B
219
−81.107
−29.311
−8.954
1.00
15.22
C


ATOM
11377
C
LEU
B
219
−81.443
−26.675
−12.599
1.00
19.16
C


ATOM
11378
O
LEU
B
219
−80.684
−25.721
−12.478
1.00
19.42
O


ATOM
11380
N
ALA
B
220
−81.368
−27.546
−13.606
1.00
19.04
N


ATOM
11381
CA
ALA
B
220
−80.356
−27.431
−14.669
1.00
19.04
C


ATOM
11383
CB
ALA
B
220
−80.648
−28.398
−15.817
1.00
18.64
C


ATOM
11387
C
ALA
B
220
−80.257
−26.004
−15.196
1.00
19.06
C


ATOM
11388
O
ALA
B
220
−79.159
−25.472
−15.321
1.00
19.08
O


ATOM
11390
N
ILE
B
221
−81.410
−25.393
−15.475
1.00
19.19
N


ATOM
11391
CA
ILE
B
221
−81.473
−24.016
−15.963
1.00
19.22
C


ATOM
11393
CB
ILE
B
221
−82.898
−23.638
−16.423
1.00
19.03
C


ATOM
11395
CG1
ILE
B
221
−83.229
−24.323
−17.755
1.00
18.52
C


ATOM
11398
CD1
ILE
B
221
−84.687
−24.645
−17.928
1.00
17.52
C


ATOM
11402
CG2
ILE
B
221
−83.024
−22.121
−16.564
1.00
18.03
C


ATOM
11406
C
ILE
B
221
−81.030
−23.013
−14.906
1.00
19.62
C


ATOM
11407
O
ILE
B
221
−80.137
−22.190
−15.136
1.00
19.53
O


ATOM
11409
N
LEU
B
222
−81.666
−23.096
−13.745
1.00
20.27
N


ATOM
11410
CA
LEU
B
222
−81.412
−22.161
−12.654
1.00
20.63
C


ATOM
11412
CB
LEU
B
222
−82.203
−22.561
−11.412
1.00
20.50
C


ATOM
11415
CG
LEU
B
222
−82.195
−21.523
−10.296
1.00
20.76
C


ATOM
11417
CD1
LEU
B
222
−83.439
−21.675
−9.431
1.00
21.02
C


ATOM
11421
CD2
LEU
B
222
−80.924
−21.625
−9.453
1.00
20.21
C


ATOM
11425
C
LEU
B
222
−79.925
−22.089
−12.341
1.00
20.98
C


ATOM
11426
O
LEU
B
222
−79.337
−21.011
−12.381
1.00
21.40
O


ATOM
11428
N
ASP
B
223
−79.319
−23.240
−12.064
1.00
21.24
N


ATOM
11429
CA
ASP
B
223
−77.907
−23.298
−11.709
1.00
21.48
C


ATOM
11431
CB
ASP
B
223
−77.509
−24.724
−11.314
1.00
21.66
C


ATOM
11434
CG
ASP
B
223
−76.168
−24.792
−10.589
1.00
22.70
C


ATOM
11435
OD1
ASP
B
223
−75.095
−24.775
−11.244
1.00
24.25
O


ATOM
11436
OD2
ASP
B
223
−76.190
−24.893
−9.349
1.00
24.85
O


ATOM
11437
C
ASP
B
223
−77.017
−22.768
−12.835
1.00
21.64
C


ATOM
11438
O
ASP
B
223
−76.035
−22.104
−12.548
1.00
21.66
O


ATOM
11440
N
TYR
B
224
−77.361
−23.023
−14.100
1.00
22.07
N


ATOM
11441
CA
TYR
B
224
−76.517
−22.561
−15.218
1.00
22.47
C


ATOM
11443
CB
TYR
B
224
−76.980
−23.111
−16.589
1.00
22.35
C


ATOM
11446
CG
TYR
B
224
−76.032
−22.733
−17.724
1.00
22.25
C


ATOM
11447
CD1
TYR
B
224
−75.002
−23.576
−18.116
1.00
21.46
C


ATOM
11449
CE1
TYR
B
224
−74.126
−23.216
−19.135
1.00
21.43
C


ATOM
11451
CZ
TYR
B
224
−74.260
−21.991
−19.761
1.00
21.62
C


ATOM
11452
OH
TYR
B
224
−73.387
−21.618
−20.760
1.00
20.46
O


ATOM
11454
CE2
TYR
B
224
−75.270
−21.132
−19.387
1.00
22.04
C


ATOM
11456
CD2
TYR
B
224
−76.144
−21.500
−18.373
1.00
22.73
C


ATOM
11458
C
TYR
B
224
−76.414
−21.023
−15.262
1.00
23.06
C


ATOM
11459
O
TYR
B
224
−75.323
−20.467
−15.507
1.00
22.89
O


ATOM
11461
N
ASN
B
225
−77.543
−20.350
−15.027
1.00
23.66
N


ATOM
11462
CA
ASN
B
225
−77.593
−18.884
−15.072
1.00
24.16
C


ATOM
11464
CB
ASN
B
225
−79.040
−18.367
−15.107
1.00
24.12
C


ATOM
11467
CG
ASN
B
225
−79.778
−18.761
−16.365
1.00
23.89
C


ATOM
11468
OD1
ASN
B
225
−79.182
−18.877
−17.437
1.00
24.33
O


ATOM
11469
ND2
ASN
B
225
−81.088
−18.965
−16.244
1.00
22.05
N


ATOM
11472
C
ASN
B
225
−76.880
−18.265
−13.881
1.00
24.73
C


ATOM
11473
O
ASN
B
225
−76.195
−17.247
−14.027
1.00
25.09
O


ATOM
11475
N
MET
B
226
−77.067
−18.864
−12.703
1.00
25.15
N


ATOM
11476
CA
MET
B
226
−76.423
−18.390
−11.479
1.00
25.53
C


ATOM
11478
CB
MET
B
226
−76.806
−19.278
−10.282
1.00
26.11
C


ATOM
11481
CG
MET
B
226
−75.905
−19.169
−9.023
1.00
27.59
C


ATOM
11484
SD
MET
B
226
−75.676
−20.788
−8.214
1.00
30.67
S


ATOM
11485
CE
MET
B
226
−77.308
−21.005
−7.476
1.00
29.78
C


ATOM
11489
C
MET
B
226
−74.920
−18.380
−11.692
1.00
25.16
C


ATOM
11490
O
MET
B
226
−74.258
−17.387
−11.391
1.00
25.10
O


ATOM
11492
N
ILE
B
227
−74.388
−19.473
−12.239
1.00
24.88
N


ATOM
11493
CA
ILE
B
227
−72.944
−19.564
−12.501
1.00
24.70
C


ATOM
11495
CB
ILE
B
227
−72.476
−20.994
−12.882
1.00
24.45
C


ATOM
11497
CG1
ILE
B
227
−72.656
−21.947
−11.695
1.00
23.80
C


ATOM
11500
CD1
ILE
B
227
−72.094
−23.332
−11.885
1.00
21.97
C


ATOM
11504
CG2
ILE
B
227
−71.030
−20.969
−13.266
1.00
24.90
C


ATOM
11508
C
ILE
B
227
−72.529
−18.550
−13.566
1.00
24.45
C


ATOM
11509
O
ILE
B
227
−71.578
−17.810
−13.373
1.00
24.42
O


ATOM
11511
N
GLN
B
228
−73.264
−18.484
−14.668
1.00
24.31
N


ATOM
11512
CA
GLN
B
228
−73.038
−17.414
−15.639
1.00
24.19
C


ATOM
11514
CB
GLN
B
228
−74.143
−17.363
−16.688
1.00
24.02
C


ATOM
11517
CG
GLN
B
228
−73.788
−16.488
−17.864
1.00
23.42
C


ATOM
11520
CD
GLN
B
228
−74.807
−16.567
−18.983
1.00
23.70
C


ATOM
11521
OE1
GLN
B
228
−75.790
−15.813
−19.015
1.00
24.07
O


ATOM
11522
NE2
GLN
B
228
−74.564
−17.465
−19.927
1.00
23.49
N


ATOM
11525
C
GLN
B
228
−72.913
−16.037
−14.987
1.00
24.37
C


ATOM
11526
O
GLN
B
228
−72.145
−15.210
−15.470
1.00
24.45
O


ATOM
11528
N
SER
B
229
−73.653
−15.776
−13.909
1.00
24.45
N


ATOM
11529
CA
SER
B
229
−73.578
−14.459
−13.264
1.00
24.76
C


ATOM
11531
CB
SER
B
229
−74.815
−14.163
−12.397
1.00
24.84
C


ATOM
11534
OG
SER
B
229
−74.711
−14.718
−11.096
1.00
25.81
O


ATOM
11536
C
SER
B
229
−72.270
−14.279
−12.469
1.00
24.64
C


ATOM
11537
O
SER
B
229
−71.726
−13.172
−12.408
1.00
24.95
O


ATOM
11539
N
VAL
B
230
−71.751
−15.350
−11.878
1.00
24.20
N


ATOM
11540
CA
VAL
B
230
−70.415
−15.277
−11.299
1.00
23.99
C


ATOM
11542
CB
VAL
B
230
−70.006
−16.581
−10.574
1.00
23.92
C


ATOM
11544
CG1
VAL
B
230
−68.546
−16.510
−10.105
1.00
23.71
C


ATOM
11548
CG2
VAL
B
230
−70.923
−16.853
−9.409
1.00
23.52
C


ATOM
11552
C
VAL
B
230
−69.386
−14.966
−12.400
1.00
24.12
C


ATOM
11553
O
VAL
B
230
−68.397
−14.291
−12.136
1.00
24.01
O


ATOM
11555
N
TYR
B
231
−69.612
−15.461
−13.621
1.00
24.30
N


ATOM
11556
CA
TYR
B
231
−68.672
−15.235
−14.728
1.00
24.53
C


ATOM
11558
CB
TYR
B
231
−68.997
−16.104
−15.946
1.00
24.08
C


ATOM
11561
CG
TYR
B
231
−68.892
−17.605
−15.754
1.00
23.29
C


ATOM
11562
CD1
TYR
B
231
−68.173
−18.168
−14.706
1.00
23.08
C


ATOM
11564
CE1
TYR
B
231
−68.073
−19.547
−14.565
1.00
22.01
C


ATOM
11566
CZ
TYR
B
231
−68.685
−20.369
−15.479
1.00
21.16
C


ATOM
11567
OH
TYR
B
231
−68.607
−21.746
−15.353
1.00
20.18
O


ATOM
11569
CE2
TYR
B
231
−69.387
−19.825
−16.523
1.00
21.64
C


ATOM
11571
CD2
TYR
B
231
−69.476
−18.464
−16.662
1.00
22.15
C


ATOM
11573
C
TYR
B
231
−68.658
−13.772
−15.166
1.00
25.37
C


ATOM
11574
O
TYR
B
231
−67.602
−13.221
−15.528
1.00
25.25
O


ATOM
11576
N
GLN
B
232
−69.832
−13.148
−15.129
1.00
26.11
N


ATOM
11577
CA
GLN
B
232
−69.978
−11.797
−15.622
1.00
26.68
C


ATOM
11579
CB
GLN
B
232
−71.430
−11.541
−15.995
1.00
26.45
C


ATOM
11582
CG
GLN
B
232
−71.883
−12.385
−17.176
1.00
25.67
C


ATOM
11585
CD
GLN
B
232
−73.388
−12.394
−17.381
1.00
24.91
C


ATOM
11586
OE1
GLN
B
232
−74.140
−11.761
−16.637
1.00
24.81
O


ATOM
11587
NE2
GLN
B
232
−73.834
−13.113
−18.407
1.00
23.39
N


ATOM
11590
C
GLN
B
232
−69.445
−10.802
−14.593
1.00
27.90
C


ATOM
11591
O
GLN
B
232
−68.909
−9.752
−14.958
1.00
27.96
O


ATOM
11593
N
ARG
B
233
−69.572
−11.145
−13.312
1.00
29.35
N


ATOM
11594
CA
ARG
B
233
−68.908
−10.396
−12.241
1.00
30.59
C


ATOM
11596
CB
ARG
B
233
−69.490
−10.775
−10.867
1.00
30.99
C


ATOM
11599
CG
ARG
B
233
−68.824
−10.114
−9.661
1.00
32.72
C


ATOM
11602
CD
ARG
B
233
−69.695
−10.210
−8.391
1.00
35.70
C


ATOM
11605
NE
ARG
B
233
−70.162
−11.578
−8.086
1.00
38.29
N


ATOM
11607
CZ
ARG
B
233
−71.403
−12.053
−8.276
1.00
39.65
C


ATOM
11608
NH1
ARG
B
233
−72.367
−11.287
−8.787
1.00
40.23
N


ATOM
11611
NH2
ARG
B
233
−71.687
−13.320
−7.949
1.00
39.61
N


ATOM
11614
C
ARG
B
233
−67.390
−10.632
−12.303
1.00
31.10
C


ATOM
11615
O
ARG
B
233
−66.615
−9.693
−12.181
1.00
31.19
O


ATOM
11617
N
ASP
B
234
−66.954
−11.868
−12.517
1.00
31.91
N


ATOM
11618
CA
ASP
B
234
−65.530
−12.102
−12.750
1.00
32.63
C


ATOM
11620
CB
ASP
B
234
−65.220
−13.566
−13.090
1.00
32.53
C


ATOM
11623
CG
ASP
B
234
−65.336
−14.493
−11.894
1.00
32.90
C


ATOM
11624
OD1
ASP
B
234
−65.477
−14.028
−10.746
1.00
33.06
O


ATOM
11625
OD2
ASP
B
234
−65.293
−15.713
−12.107
1.00
34.22
O


ATOM
11626
C
ASP
B
234
−65.058
−11.206
−13.886
1.00
33.10
C


ATOM
11627
O
ASP
B
234
−64.097
−10.458
−13.723
1.00
33.55
O


ATOM
11629
N
LEU
B
235
−65.753
−11.256
−15.017
1.00
33.49
N


ATOM
11630
CA
LEU
B
235
−65.311
−10.550
−16.216
1.00
34.06
C


ATOM
11632
CB
LEU
B
235
−66.139
−10.996
−17.422
1.00
33.80
C


ATOM
11635
CG
LEU
B
235
−65.769
−10.403
−18.775
1.00
32.13
C


ATOM
11637
CD1
LEU
B
235
−64.303
−10.679
−19.050
1.00
30.94
C


ATOM
11641
CD2
LEU
B
235
−66.670
−10.959
−19.870
1.00
29.93
C


ATOM
11645
C
LEU
B
235
−65.345
−9.023
−16.103
1.00
35.40
C


ATOM
11646
O
LEU
B
235
−64.500
−8.352
−16.682
1.00
35.61
O


ATOM
11648
N
ARG
B
236
−66.327
−8.473
−15.386
1.00
36.92
N


ATOM
11649
CA
ARG
B
236
−66.380
−7.019
−15.137
1.00
38.06
C


ATOM
11651
CB
ARG
B
236
−67.650
−6.607
−14.367
1.00
38.43
C


ATOM
11654
CG
ARG
B
236
−68.882
−6.321
−15.230
1.00
39.58
C


ATOM
11657
CD
ARG
B
236
−69.958
−5.520
−14.459
1.00
40.93
C


ATOM
11660
NE
ARG
B
236
−70.383
−6.149
−13.199
1.00
41.74
N


ATOM
11662
CZ
ARG
B
236
−71.208
−7.195
−13.095
1.00
42.20
C


ATOM
11663
NH1
ARG
B
236
−71.719
−7.784
−14.175
1.00
41.61
N


ATOM
11666
NH2
ARG
B
236
−71.517
−7.672
−11.892
1.00
42.99
N


ATOM
11669
C
ARG
B
236
−65.170
−6.550
−14.343
1.00
38.57
C


ATOM
11670
O
ARG
B
236
−64.593
−5.524
−14.665
1.00
38.61
O


ATOM
11672
N
GLU
B
237
−64.822
−7.292
−13.291
1.00
39.42
N


ATOM
11673
CA
GLU
B
237
−63.625
−7.017
−12.480
1.00
40.18
C


ATOM
11675
CB
GLU
B
237
−63.471
−8.033
−11.317
1.00
40.67
C


ATOM
11678
CG
GLU
B
237
−64.336
−7.750
−10.057
1.00
42.61
C


ATOM
11681
CD
GLU
B
237
−64.258
−8.858
−8.961
1.00
45.07
C


ATOM
11682
OE1
GLU
B
237
−64.051
−10.066
−9.282
1.00
46.74
O


ATOM
11683
OE2
GLU
B
237
−64.436
−8.511
−7.764
1.00
45.87
O


ATOM
11684
C
GLU
B
237
−62.352
−7.024
−13.344
1.00
39.93
C


ATOM
11685
O
GLU
B
237
−61.593
−6.050
−13.332
1.00
39.96
O


ATOM
11687
N
THR
B
238
−62.123
−8.104
−14.095
1.00
39.56
N


ATOM
11688
CA
THR
B
238
−60.900
−8.200
−14.895
1.00
39.42
C


ATOM
11690
CB
THR
B
238
−60.492
−9.666
−15.268
1.00
39.39
C


ATOM
11692
OG1
THR
B
238
−61.222
−10.123
−16.413
1.00
39.37
O


ATOM
11694
CG2
THR
B
238
−60.683
−10.612
−14.095
1.00
38.73
C


ATOM
11698
C
THR
B
238
−60.961
−7.326
−16.156
1.00
39.48
C


ATOM
11699
O
THR
B
238
−59.930
−7.062
−16.761
1.00
39.48
O


ATOM
11701
N
SER
B
239
−62.149
−6.871
−16.549
1.00
39.62
N


ATOM
11702
CA
SER
B
239
−62.264
−5.882
−17.631
1.00
39.63
C


ATOM
11704
CB
SER
B
239
−63.689
−5.810
−18.172
1.00
39.56
C


ATOM
11707
OG
SER
B
239
−63.945
−6.917
−19.010
1.00
38.96
O


ATOM
11709
C
SER
B
239
−61.796
−4.496
−17.181
1.00
39.99
C


ATOM
11710
O
SER
B
239
−61.108
−3.807
−17.933
1.00
40.10
O


ATOM
11712
N
ARG
B
240
−62.168
−4.088
−15.965
1.00
40.35
N


ATOM
11713
CA
ARG
B
240
−61.624
−2.864
−15.363
1.00
40.68
C


ATOM
11715
CB
ARG
B
240
−62.025
−2.712
−13.881
1.00
41.26
C


ATOM
11718
CG
ARG
B
240
−63.231
−1.782
−13.621
1.00
43.86
C


ATOM
11721
CD
ARG
B
240
−63.334
−1.375
−12.130
1.00
47.07
C


ATOM
11724
NE
ARG
B
240
−63.365
−2.537
−11.222
1.00
50.14
N


ATOM
11726
CZ
ARG
B
240
−64.462
−3.077
−10.671
1.00
52.32
C


ATOM
11727
NH1
ARG
B
240
−64.342
−4.141
−9.875
1.00
53.16
N


ATOM
11730
NH2
ARG
B
240
−65.677
−2.577
−10.899
1.00
53.18
N


ATOM
11733
C
ARG
B
240
−60.113
−2.914
−15.464
1.00
39.91
C


ATOM
11734
O
ARG
B
240
−59.490
−2.000
−15.988
1.00
39.86
O


ATOM
11736
N
TRP
B
241
−59.541
−4.002
−14.962
1.00
39.14
N


ATOM
11737
CA
TRP
B
241
−58.105
−4.217
−15.004
1.00
38.37
C


ATOM
11739
CB
TRP
B
241
−57.773
−5.635
−14.521
1.00
38.17
C


ATOM
11742
CG
TRP
B
241
−56.373
−6.005
−14.773
1.00
36.58
C


ATOM
11743
CD1
TRP
B
241
−55.290
−5.668
−14.022
1.00
36.32
C


ATOM
11745
NE1
TRP
B
241
−54.152
−6.176
−14.587
1.00
35.63
N


ATOM
11747
CE2
TRP
B
241
−54.494
−6.846
−15.731
1.00
34.31
C


ATOM
11748
CD2
TRP
B
241
−55.883
−6.757
−15.874
1.00
33.99
C


ATOM
11749
CE3
TRP
B
241
−56.484
−7.357
−16.977
1.00
33.28
C


ATOM
11751
CZ3
TRP
B
241
−55.691
−8.034
−17.883
1.00
32.79
C


ATOM
11753
CH2
TRP
B
241
−54.313
−8.101
−17.720
1.00
33.06
C


ATOM
11755
CZ2
TRP
B
241
−53.697
−7.515
−16.648
1.00
34.16
C


ATOM
11757
C
TRP
B
241
−57.561
−3.999
−16.409
1.00
38.25
C


ATOM
11758
O
TRP
B
241
−56.607
−3.252
−16.603
1.00
38.13
O


ATOM
11760
N
TRP
B
242
−58.186
−4.644
−17.386
1.00
38.21
N


ATOM
11761
CA
TRP
B
242
−57.695
−4.628
−18.765
1.00
38.27
C


ATOM
11763
CB
TRP
B
242
−58.479
−5.640
−19.609
1.00
38.31
C


ATOM
11766
CG
TRP
B
242
−57.948
−5.872
−20.990
1.00
38.61
C


ATOM
11767
CD1
TRP
B
242
−58.642
−5.754
−22.156
1.00
39.11
C


ATOM
11769
NE1
TRP
B
242
−57.828
−6.046
−23.224
1.00
39.31
N


ATOM
11771
CE2
TRP
B
242
−56.582
−6.363
−22.759
1.00
38.95
C


ATOM
11772
CD2
TRP
B
242
−56.617
−6.263
−21.356
1.00
38.66
C


ATOM
11773
CE3
TRP
B
242
−55.454
−6.528
−20.637
1.00
38.98
C


ATOM
11775
CZ3
TRP
B
242
−54.314
−6.886
−21.326
1.00
39.20
C


ATOM
11777
CH2
TRP
B
242
−54.313
−6.985
−22.716
1.00
39.12
C


ATOM
11779
CZ2
TRP
B
242
−55.434
−6.724
−23.451
1.00
39.22
C


ATOM
11781
C
TRP
B
242
−57.739
−3.241
−19.400
1.00
38.27
C


ATOM
11782
O
TRP
B
242
−56.814
−2.873
−20.108
1.00
37.81
O


ATOM
11784
N
ARG
B
243
−58.809
−2.489
−19.140
1.00
38.79
N


ATOM
11785
CA
ARG
B
243
−58.936
−1.097
−19.607
1.00
39.37
C


ATOM
11787
CB
ARG
B
243
−60.351
−.552
−19.346
1.00
39.66
C


ATOM
11790
CG
ARG
B
243
−61.324
−.792
−20.520
1.00
41.96
C


ATOM
11793
CD
ARG
B
243
−62.687
−1.338
−20.085
1.00
44.82
C


ATOM
11796
NE
ARG
B
243
−63.461
−.380
−19.296
1.00
47.15
N


ATOM
11798
CZ
ARG
B
243
−64.389
−.704
−18.386
1.00
49.26
C


ATOM
11799
NH1
ARG
B
243
−64.685
−1.976
−18.109
1.00
49.18
N


ATOM
11802
NH2
ARG
B
243
−65.028
.262
−17.729
1.00
50.40
N


ATOM
11805
C
ARG
B
243
−57.890
−.183
−18.980
1.00
39.28
C


ATOM
11806
O
ARG
B
243
−57.246
.577
−19.681
1.00
39.40
O


ATOM
11808
N
ARG
B
244
−57.724
−.282
−17.665
1.00
39.52
N


ATOM
11809
CA
ARG
B
244
−56.734
.489
−16.888
1.00
39.61
C


ATOM
11811
CB
ARG
B
244
−56.774
.041
−15.409
1.00
40.25
C


ATOM
11814
CG
ARG
B
244
−56.115
.971
−14.383
1.00
42.01
C


ATOM
11817
CD
ARG
B
244
−57.029
2.154
−14.017
1.00
44.39
C


ATOM
11820
NE
ARG
B
244
−56.391
3.115
−13.103
1.00
46.36
N


ATOM
11822
CZ
ARG
B
244
−55.434
3.984
−13.441
1.00
48.06
C


ATOM
11823
NH1
ARG
B
244
−54.951
4.043
−14.686
1.00
48.90
N


ATOM
11826
NH2
ARG
B
244
−54.947
4.805
−12.519
1.00
48.82
N


ATOM
11829
C
ARG
B
244
−55.323
.322
−17.437
1.00
38.83
C


ATOM
11830
O
ARG
B
244
−54.594
1.300
−17.567
1.00
38.39
O


ATOM
11832
N
VAL
B
245
−54.953
−.922
−17.738
1.00
38.52
N


ATOM
11833
CA
VAL
B
245
−53.694
−1.241
−18.437
1.00
38.43
C


ATOM
11835
CB
VAL
B
245
−53.491
−2.760
−18.614
1.00
38.31
C


ATOM
11837
CG1
VAL
B
245
−53.247
−3.426
−17.283
1.00
37.77
C


ATOM
11841
CG2
VAL
B
245
−52.344
−3.036
−19.561
1.00
37.66
C


ATOM
11845
C
VAL
B
245
−53.650
−.638
−19.832
1.00
38.68
C


ATOM
11846
O
VAL
B
245
−52.615
−.153
−20.247
1.00
38.57
O


ATOM
11848
N
GLY
B
246
−54.765
−.724
−20.559
1.00
39.26
N


ATOM
11849
CA
GLY
B
246
−54.974
−.012
−21.834
1.00
39.62
C


ATOM
11852
C
GLY
B
246
−53.962
−.262
−22.942
1.00
40.08
C


ATOM
11853
O
GLY
B
246
−53.617
.650
−23.700
1.00
39.89
O


ATOM
11855
N
LEU
B
247
−53.502
−1.500
−23.062
1.00
40.75
N


ATOM
11856
CA
LEU
B
247
−52.347
−1.778
−23.905
1.00
41.34
C


ATOM
11858
CB
LEU
B
247
−51.655
−3.065
−23.459
1.00
41.15
C


ATOM
11861
CG
LEU
B
247
−50.132
−3.026
−23.298
1.00
40.49
C


ATOM
11863
CD1
LEU
B
247
−49.622
−1.769
−22.605
1.00
39.50
C


ATOM
11867
CD2
LEU
B
247
−49.695
−4.242
−22.526
1.00
39.98
C


ATOM
11871
C
LEU
B
247
−52.744
−1.836
−25.370
1.00
42.50
C


ATOM
11872
O
LEU
B
247
−52.005
−1.358
−26.225
1.00
42.33
O


ATOM
11874
N
ALA
B
248
−53.925
−2.390
−25.654
1.00
44.14
N


ATOM
11875
CA
ALA
B
248
−54.439
−2.494
−27.041
1.00
45.16
C


ATOM
11877
CB
ALA
B
248
−55.705
−3.347
−27.087
1.00
45.15
C


ATOM
11881
C
ALA
B
248
−54.692
−1.140
−27.739
1.00
45.98
C


ATOM
11882
O
ALA
B
248
−54.604
−1.053
−28.971
1.00
46.37
O


ATOM
11884
N
THR
B
249
−55.004
−.095
−26.975
1.00
46.64
N


ATOM
11885
CA
THR
B
249
−55.142
1.234
−27.570
1.00
47.25
C


ATOM
11887
CB
THR
B
249
−55.905
2.253
−26.655
1.00
47.44
C


ATOM
11889
OG1
THR
B
249
−55.001
2.845
−25.706
1.00
47.52
O


ATOM
11891
CG2
THR
B
249
−57.104
1.592
−25.928
1.00
47.44
C


ATOM
11895
C
THR
B
249
−53.756
1.793
−27.931
1.00
47.59
C


ATOM
11896
O
THR
B
249
−53.553
2.279
−29.049
1.00
48.07
O


ATOM
11898
N
LYS
B
250
−52.808
1.710
−26.995
1.00
47.67
N


ATOM
11899
CA
LYS
B
250
−51.469
2.299
−27.185
1.00
47.68
C


ATOM
11901
CB
LYS
B
250
−50.793
2.553
−25.833
1.00
47.68
C


ATOM
11904
CG
LYS
B
250
−51.428
3.673
−24.999
1.00
47.77
C


ATOM
11907
CD
LYS
B
250
−51.142
5.086
−25.552
1.00
47.59
C


ATOM
11910
CE
LYS
B
250
−49.676
5.496
−25.441
1.00
46.75
C


ATOM
11913
NZ
LYS
B
250
−49.479
6.878
−25.948
1.00
46.49
N


ATOM
11917
C
LYS
B
250
−50.541
1.465
−28.082
1.00
47.72
C


ATOM
11918
O
LYS
B
250
−49.591
1.988
−28.663
1.00
47.54
O


ATOM
11920
N
LEU
B
251
−50.804
.169
−28.184
1.00
47.82
N


ATOM
11921
CA
LEU
B
251
−50.072
−.675
−29.118
1.00
47.96
C


ATOM
11923
CB
LEU
B
251
−49.584
−1.970
−28.447
1.00
48.04
C


ATOM
11926
CG
LEU
B
251
−48.109
−2.064
−28.033
1.00
47.39
C


ATOM
11928
CD1
LEU
B
251
−47.659
−.881
−27.186
1.00
46.47
C


ATOM
11932
CD2
LEU
B
251
−47.894
−3.376
−27.304
1.00
46.78
C


ATOM
11936
C
LEU
B
251
−50.985
−.964
−30.306
1.00
48.19
C


ATOM
11937
O
LEU
B
251
−51.975
−1.693
−30.194
1.00
48.38
O


ATOM
11939
N
HIS
B
252
−50.627
−.396
−31.449
1.00
48.42
N


ATOM
11940
CA
HIS
B
252
−51.521
−.329
−32.601
1.00
48.62
C


ATOM
11942
CB
HIS
B
252
−51.110
.850
−33.492
1.00
48.99
C


ATOM
11945
CG
HIS
B
252
−51.000
2.145
−32.742
1.00
50.56
C


ATOM
11946
ND1
HIS
B
252
−52.095
2.935
−32.453
1.00
52.11
N


ATOM
11948
CE1
HIS
B
252
−51.704
3.993
−31.766
1.00
52.68
C


ATOM
11950
NE2
HIS
B
252
−50.397
3.912
−31.585
1.00
52.86
N


ATOM
11952
CD2
HIS
B
252
−49.932
2.764
−32.181
1.00
51.68
C


ATOM
11954
C
HIS
B
252
−51.582
−1.636
−33.383
1.00
48.14
C


ATOM
11955
O
HIS
B
252
−52.615
−1.975
−33.935
1.00
48.02
O


ATOM
11957
N
PHE
B
253
−50.481
−2.372
−33.405
1.00
48.10
N


ATOM
11958
CA
PHE
B
253
−50.422
−3.702
−34.044
1.00
48.18
C


ATOM
11960
CB
PHE
B
253
−48.965
−4.070
−34.375
1.00
48.16
C


ATOM
11963
CG
PHE
B
253
−48.119
−4.311
−33.163
1.00
47.85
C


ATOM
11964
CD1
PHE
B
253
−47.900
−5.596
−32.702
1.00
48.56
C


ATOM
11966
CE1
PHE
B
253
−47.140
−5.812
−31.576
1.00
48.98
C


ATOM
11968
CZ
PHE
B
253
−46.602
−4.729
−30.895
1.00
48.50
C


ATOM
11970
CE2
PHE
B
253
−46.817
−3.454
−31.349
1.00
47.40
C


ATOM
11972
CD2
PHE
B
253
−47.569
−3.249
−32.465
1.00
47.22
C


ATOM
11974
C
PHE
B
253
−51.038
−4.819
−33.185
1.00
48.30
C


ATOM
11975
O
PHE
B
253
−51.344
−5.903
−33.691
1.00
47.63
O


ATOM
11977
N
ALA
B
254
−51.204
−4.541
−31.888
1.00
48.86
N


ATOM
11978
CA
ALA
B
254
−51.653
−5.531
−30.903
1.00
49.13
C


ATOM
11980
CB
ALA
B
254
−51.290
−5.071
−29.494
1.00
49.02
C


ATOM
11984
C
ALA
B
254
−53.153
−5.806
−30.982
1.00
49.46
C


ATOM
11985
O
ALA
B
254
−53.967
−4.870
−31.011
1.00
49.50
O


ATOM
11987
N
ARG
B
255
−53.501
−7.097
−31.006
1.00
49.75
N


ATOM
11988
CA
ARG
B
255
−54.896
−7.549
−30.918
1.00
49.89
C


ATOM
11990
CB
ARG
B
255
−55.028
−9.051
−31.245
1.00
49.94
C


ATOM
11993
CG
ARG
B
255
−54.839
−9.439
−32.724
1.00
49.93
C


ATOM
11996
CD
ARG
B
255
−54.709
−10.967
−32.904
1.00
49.79
C


ATOM
11999
NE
ARG
B
255
−53.527
−11.505
−32.219
1.00
50.11
N


ATOM
12001
CZ
ARG
B
255
−53.276
−12.801
−32.010
1.00
50.54
C


ATOM
12002
NH1
ARG
B
255
−54.117
−13.736
−32.439
1.00
51.36
N


ATOM
12005
NH2
ARG
B
255
−52.175
−13.172
−31.360
1.00
50.21
N


ATOM
12008
C
ARG
B
255
−55.425
−7.308
−29.511
1.00
49.83
C


ATOM
12009
O
ARG
B
255
−54.666
−6.975
−28.599
1.00
49.95
O


ATOM
12011
N
ASP
B
256
−56.736
−7.463
−29.350
1.00
49.72
N


ATOM
12012
CA
ASP
B
256
−57.360
−7.483
−28.034
1.00
49.55
C


ATOM
12014
CB
ASP
B
256
−58.183
−6.222
−27.812
1.00
49.52
C


ATOM
12017
CG
ASP
B
256
−59.134
−6.362
−26.654
1.00
50.30
C


ATOM
12018
OD1
ASP
B
256
−60.310
−5.944
−26.780
1.00
50.45
O


ATOM
12019
OD2
ASP
B
256
−58.702
−6.926
−25.622
1.00
51.68
O


ATOM
12020
C
ASP
B
256
−58.254
−8.721
−27.931
1.00
49.15
C


ATOM
12021
O
ASP
B
256
−59.159
−8.901
−28.737
1.00
49.28
O


ATOM
12023
N
ARG
B
257
−57.998
−9.565
−26.937
1.00
48.61
N


ATOM
12024
CA
ARG
B
257
−58.743
−10.809
−26.765
1.00
48.20
C


ATOM
12026
CB
ARG
B
257
−57.949
−11.984
−27.373
1.00
48.41
C


ATOM
12029
CG
ARG
B
257
−57.505
−11.799
−28.821
1.00
49.37
C


ATOM
12032
CD
ARG
B
257
−58.693
−11.636
−29.784
1.00
50.80
C


ATOM
12035
NE
ARG
B
257
−58.908
−12.814
−30.627
1.00
52.11
N


ATOM
12037
CZ
ARG
B
257
−58.678
−12.876
−31.944
1.00
52.99
C


ATOM
12038
NH1
ARG
B
257
−58.214
−11.820
−32.623
1.00
52.37
N


ATOM
12041
NH2
ARG
B
257
−58.918
−14.016
−32.596
1.00
52.97
N


ATOM
12044
C
ARG
B
257
−59.032
−11.089
−25.280
1.00
47.32
C


ATOM
12045
O
ARG
B
257
−58.579
−12.101
−24.735
1.00
47.46
O


ATOM
12047
N
LEU
B
258
−59.770
−10.201
−24.616
1.00
45.94
N


ATOM
12048
CA
LEU
B
258
−60.108
−10.430
−23.205
1.00
44.67
C


ATOM
12050
CB
LEU
B
258
−60.332
−9.130
−22.438
1.00
44.61
C


ATOM
12053
CG
LEU
B
258
−60.422
−9.323
−20.920
1.00
43.83
C


ATOM
12055
CD1
LEU
B
258
−59.045
−9.552
−20.339
1.00
43.48
C


ATOM
12059
CD2
LEU
B
258
−61.073
−8.139
−20.262
1.00
43.85
C


ATOM
12063
C
LEU
B
258
−61.347
−11.286
−23.090
1.00
43.49
C


ATOM
12064
O
LEU
B
258
−61.375
−12.220
−22.295
1.00
43.84
O


ATOM
12066
N
ILE
B
259
−62.364
−10.968
−23.883
1.00
41.92
N


ATOM
12067
CA
ILE
B
259
−63.617
−11.711
−23.841
1.00
40.80
C


ATOM
12069
CB
ILE
B
259
−64.718
−11.132
−24.783
1.00
41.05
C


ATOM
12071
CG1
ILE
B
259
−64.852
−9.598
−24.653
1.00
41.61
C


ATOM
12074
CD1
ILE
B
259
−65.200
−8.874
−25.985
1.00
42.16
C


ATOM
12078
CG2
ILE
B
259
−66.065
−11.816
−24.496
1.00
40.46
C


ATOM
12082
C
ILE
B
259
−63.319
−13.151
−24.250
1.00
39.50
C


ATOM
12083
O
ILE
B
259
−63.782
−14.082
−23.598
1.00
39.30
O


ATOM
12085
N
GLU
B
260
−62.524
−13.318
−25.316
1.00
37.99
N


ATOM
12086
CA
GLU
B
260
−62.120
−14.652
−25.812
1.00
36.60
C


ATOM
12088
CB
GLU
B
260
−61.329
−14.574
−27.142
1.00
36.75
C


ATOM
12091
CG
GLU
B
260
−62.167
−14.319
−28.425
1.00
37.79
C


ATOM
12094
CD
GLU
B
260
−62.134
−12.851
−28.905
1.00
39.47
C


ATOM
12095
OE1
GLU
B
260
−62.207
−11.923
−28.055
1.00
39.97
O


ATOM
12096
OE2
GLU
B
260
−62.033
−12.628
−30.139
1.00
40.31
O


ATOM
12097
C
GLU
B
260
−61.282
−15.381
−24.770
1.00
34.83
C


ATOM
12098
O
GLU
B
260
−61.465
−16.568
−24.544
1.00
34.69
O


ATOM
12100
N
SER
B
261
−60.365
−14.669
−24.131
1.00
32.89
N


ATOM
12101
CA
SER
B
261
−59.508
−15.292
−23.139
1.00
31.48
C


ATOM
12103
CB
SER
B
261
−58.341
−14.376
−22.768
1.00
31.55
C


ATOM
12106
OG
SER
B
261
−57.298
−14.493
−23.728
1.00
31.75
O


ATOM
12108
C
SER
B
261
−60.294
−15.716
−21.900
1.00
30.04
C


ATOM
12109
O
SER
B
261
−59.921
−16.674
−21.208
1.00
29.70
O


ATOM
12111
N
PHE
B
262
−61.389
−15.021
−21.618
1.00
28.25
N


ATOM
12112
CA
PHE
B
262
−62.203
−15.404
−20.480
1.00
26.75
C


ATOM
12114
CB
PHE
B
262
−63.111
−14.278
−20.009
1.00
26.36
C


ATOM
12117
CG
PHE
B
262
−63.532
−14.453
−18.603
1.00
24.33
C


ATOM
12118
CD1
PHE
B
262
−62.697
−14.092
−17.584
1.00
22.66
C


ATOM
12120
CE1
PHE
B
262
−63.047
−14.283
−16.301
1.00
22.65
C


ATOM
12122
CZ
PHE
B
262
−64.245
−14.873
−16.007
1.00
23.93
C


ATOM
12124
CE2
PHE
B
262
−65.076
−15.267
−17.010
1.00
24.08
C


ATOM
12126
CD2
PHE
B
262
−64.711
−15.067
−18.304
1.00
23.96
C


ATOM
12128
C
PHE
B
262
−63.017
−16.660
−20.751
1.00
26.02
C


ATOM
12129
O
PHE
B
262
−63.074
−17.546
−19.909
1.00
26.32
O


ATOM
12131
N
TYR
B
263
−63.652
−16.732
−21.915
1.00
24.98
N


ATOM
12132
CA
TYR
B
263
−64.299
−17.969
−22.396
1.00
24.14
C


ATOM
12134
CB
TYR
B
263
−64.701
−17.756
−23.853
1.00
24.00
C


ATOM
12137
CG
TYR
B
263
−65.080
−18.961
−24.667
1.00
24.32
C


ATOM
12138
CD1
TYR
B
263
−66.302
−19.604
−24.489
1.00
25.03
C


ATOM
12140
CE1
TYR
B
263
−66.666
−20.694
−25.285
1.00
25.81
C


ATOM
12142
CZ
TYR
B
263
−65.798
−21.132
−26.287
1.00
27.06
C


ATOM
12143
OH
TYR
B
263
−66.106
−22.191
−27.123
1.00
27.14
O


ATOM
12145
CE2
TYR
B
263
−64.590
−20.489
−26.479
1.00
26.80
C


ATOM
12147
CD2
TYR
B
263
−64.250
−19.404
−25.680
1.00
25.65
C


ATOM
12149
C
TYR
B
263
−63.351
−19.162
−22.256
1.00
23.35
C


ATOM
12150
O
TYR
B
263
−63.712
−20.219
−21.740
1.00
22.80
O


ATOM
12152
N
TRP
B
264
−62.119
−18.955
−22.702
1.00
22.64
N


ATOM
12153
CA
TRP
B
264
−61.047
−19.918
−22.523
1.00
21.95
C


ATOM
12155
CB
TRP
B
264
−59.737
−19.334
−23.061
1.00
21.84
C


ATOM
12158
CG
TRP
B
264
−58.603
−20.278
−22.964
1.00
22.90
C


ATOM
12159
CD1
TRP
B
264
−57.700
−20.387
−21.943
1.00
23.98
C


ATOM
12161
NE1
TRP
B
264
−56.800
−21.386
−22.214
1.00
23.95
N


ATOM
12163
CE2
TRP
B
264
−57.124
−21.949
−23.417
1.00
23.51
C


ATOM
12164
CD2
TRP
B
264
−58.252
−21.273
−23.915
1.00
23.40
C


ATOM
12165
CE3
TRP
B
264
−58.776
−21.652
−25.147
1.00
23.68
C


ATOM
12167
CZ3
TRP
B
264
−58.178
−22.669
−25.826
1.00
24.44
C


ATOM
12169
CH2
TRP
B
264
−57.060
−23.324
−25.310
1.00
24.97
C


ATOM
12171
CZ2
TRP
B
264
−56.521
−22.978
−24.103
1.00
24.44
C


ATOM
12173
C
TRP
B
264
−60.897
−20.326
−21.050
1.00
21.11
C


ATOM
12174
O
TRP
B
264
−60.768
−21.511
−20.748
1.00
20.98
O


ATOM
12176
N
ALA
B
265
−60.916
−19.344
−20.147
1.00
20.17
N


ATOM
12177
CA
ALA
B
265
−60.774
−19.602
−18.712
1.00
19.36
C


ATOM
12179
CB
ALA
B
265
−60.621
−18.305
−17.944
1.00
19.30
C


ATOM
12183
C
ALA
B
265
−61.947
−20.397
−18.171
1.00
18.63
C


ATOM
12184
O
ALA
B
265
−61.763
−21.349
−17.434
1.00
18.64
O


ATOM
12186
N
VAL
B
266
−63.159
−20.034
−18.557
1.00
18.11
N


ATOM
12187
CA
VAL
B
266
−64.335
−20.758
−18.075
1.00
17.60
C


ATOM
12189
CB
VAL
B
266
−65.652
−20.221
−18.675
1.00
17.38
C


ATOM
12191
CG1
VAL
B
266
−65.902
−18.803
−18.199
1.00
17.09
C


ATOM
12195
CG2
VAL
B
266
−66.817
−21.120
−18.312
1.00
15.40
C


ATOM
12199
C
VAL
B
266
−64.221
−22.246
−18.376
1.00
17.67
C


ATOM
12200
O
VAL
B
266
−64.766
−23.058
−17.647
1.00
18.27
O


ATOM
12202
N
GLY
B
267
−63.516
−22.607
−19.444
1.00
17.43
N


ATOM
12203
CA
GLY
B
267
−63.316
−24.013
−19.789
1.00
16.98
C


ATOM
12206
C
GLY
B
267
−62.253
−24.683
−18.947
1.00
16.55
C


ATOM
12207
O
GLY
B
267
−62.360
−25.859
−18.609
1.00
16.37
O


ATOM
12209
N
VAL
B
268
−61.215
−23.939
−18.608
1.00
16.30
N


ATOM
12210
CA
VAL
B
268
−60.160
−24.500
−17.794
1.00
16.23
C


ATOM
12212
CB
VAL
B
268
−58.893
−23.651
−17.840
1.00
15.68
C


ATOM
12214
CG1
VAL
B
268
−57.857
−24.194
−16.894
1.00
15.01
C


ATOM
12218
CG2
VAL
B
268
−58.361
−23.674
−19.235
1.00
15.01
C


ATOM
12222
C
VAL
B
268
−60.654
−24.718
−16.374
1.00
16.86
C


ATOM
12223
O
VAL
B
268
−60.421
−25.784
−15.813
1.00
16.93
O


ATOM
12225
N
ALA
B
269
−61.362
−23.733
−15.817
1.00
17.64
N


ATOM
12226
CA
ALA
B
269
−61.911
−23.838
−14.461
1.00
18.46
C


ATOM
12228
CB
ALA
B
269
−60.958
−23.215
−13.472
1.00
18.15
C


ATOM
12232
C
ALA
B
269
−63.312
−23.213
−14.340
1.00
19.34
C


ATOM
12233
O
ALA
B
269
−63.448
−22.030
−14.047
1.00
19.78
O


ATOM
12235
N
PHE
B
270
−64.347
−24.028
−14.529
1.00
20.34
N


ATOM
12236
CA
PHE
B
270
−65.724
−23.535
−14.631
1.00
21.21
C


ATOM
12238
CB
PHE
B
270
−66.564
−24.483
−15.482
1.00
21.34
C


ATOM
12241
CG
PHE
B
270
−67.083
−25.667
−14.718
1.00
22.46
C


ATOM
12242
CD1
PHE
B
270
−68.294
−25.596
−14.039
1.00
23.19
C


ATOM
12244
CE1
PHE
B
270
−68.756
−26.672
−13.315
1.00
23.27
C


ATOM
12246
CZ
PHE
B
270
−68.003
−27.836
−13.258
1.00
23.35
C


ATOM
12248
CE2
PHE
B
270
−66.794
−27.918
−13.932
1.00
22.73
C


ATOM
12250
CD2
PHE
B
270
−66.340
−26.843
−14.646
1.00
22.88
C


ATOM
12252
C
PHE
B
270
−66.464
−23.366
−13.316
1.00
21.98
C


ATOM
12253
O
PHE
B
270
−67.408
−22.583
−13.268
1.00
21.93
O


ATOM
12255
N
GLU
B
271
−66.102
−24.126
−12.275
1.00
23.01
N


ATOM
12256
CA
GLU
B
271
−66.929
−24.142
−11.037
1.00
23.99
C


ATOM
12258
CB
GLU
B
271
−66.679
−25.353
−10.113
1.00
24.25
C


ATOM
12261
CG
GLU
B
271
−65.286
−25.877
−10.092
1.00
26.22
C


ATOM
12264
CD
GLU
B
271
−65.013
−26.914
−11.183
1.00
29.01
C


ATOM
12265
OE1
GLU
B
271
−65.563
−28.032
−11.090
1.00
31.36
O


ATOM
12266
OE2
GLU
B
271
−64.232
−26.622
−12.121
1.00
30.98
O


ATOM
12267
C
GLU
B
271
−66.795
−22.831
−10.281
1.00
23.90
C


ATOM
12268
O
GLU
B
271
−65.702
−22.296
−10.181
1.00
24.29
O


ATOM
12270
N
PRO
B
272
−67.913
−22.316
−9.745
1.00
24.09
N


ATOM
12271
CA
PRO
B
272
−68.005
−20.885
−9.428
1.00
24.11
C


ATOM
12273
CB
PRO
B
272
−69.380
−20.751
−8.751
1.00
24.03
C


ATOM
12276
CG
PRO
B
272
−70.083
−22.069
−8.997
1.00
24.12
C


ATOM
12279
CD
PRO
B
272
−69.013
−23.083
−9.132
1.00
23.99
C


ATOM
12282
C
PRO
B
272
−66.900
−20.386
−8.501
1.00
24.28
C


ATOM
12283
O
PRO
B
272
−66.421
−19.261
−8.676
1.00
24.40
O


ATOM
12284
N
GLN
B
273
−66.480
−21.222
−7.547
1.00
24.20
N


ATOM
12285
CA
GLN
B
273
−65.500
−20.809
−6.551
1.00
24.20
C


ATOM
12287
CB
GLN
B
273
−65.437
−21.840
−5.426
1.00
24.42
C


ATOM
12290
CG
GLN
B
273
−64.750
−23.176
−5.775
1.00
25.17
C


ATOM
12293
CD
GLN
B
273
−65.717
−24.334
−6.007
1.00
26.13
C


ATOM
12294
OE1
GLN
B
273
−66.857
−24.141
−6.453
1.00
27.46
O


ATOM
12295
NE2
GLN
B
273
−65.251
−25.554
−5.721
1.00
25.05
N


ATOM
12298
C
GLN
B
273
−64.086
−20.546
−7.088
1.00
24.27
C


ATOM
12299
O
GLN
B
273
−63.221
−20.151
−6.329
1.00
24.32
O


ATOM
12301
N
TYR
B
274
−63.842
−20.759
−8.380
1.00
24.59
N


ATOM
12302
CA
TYR
B
274
−62.509
−20.551
−8.962
1.00
24.85
C


ATOM
12304
CB
TYR
B
274
−62.129
−21.724
−9.880
1.00
24.62
C


ATOM
12307
CG
TYR
B
274
−62.009
−23.054
−9.184
1.00
24.35
C


ATOM
12308
CD1
TYR
B
274
−61.395
−23.169
−7.946
1.00
24.62
C


ATOM
12310
CE1
TYR
B
274
−61.280
−24.391
−7.314
1.00
25.10
C


ATOM
12312
CZ
TYR
B
274
−61.771
−25.525
−7.920
1.00
24.92
C


ATOM
12313
OH
TYR
B
274
−61.661
−26.748
−7.299
1.00
24.73
O


ATOM
12315
CE2
TYR
B
274
−62.366
−25.437
−9.150
1.00
24.76
C


ATOM
12317
CD2
TYR
B
274
−62.477
−24.203
−9.779
1.00
24.70
C


ATOM
12319
C
TYR
B
274
−62.409
−19.235
−9.745
1.00
25.27
C


ATOM
12320
O
TYR
B
274
−61.956
−19.210
−10.895
1.00
25.42
O


ATOM
12322
N
SER
B
275
−62.808
−18.134
−9.121
1.00
25.40
N


ATOM
12323
CA
SER
B
275
−62.755
−16.849
−9.802
1.00
25.43
C


ATOM
12325
CB
SER
B
275
−63.615
−15.814
−9.071
1.00
25.53
C


ATOM
12328
OG
SER
B
275
−65.006
−16.068
−9.291
1.00
25.52
O


ATOM
12330
C
SER
B
275
−61.300
−16.403
−9.948
1.00
25.36
C


ATOM
12331
O
SER
B
275
−60.885
−15.903
−10.996
1.00
25.17
O


ATOM
12333
N
ASP
B
276
−60.517
−16.617
−8.901
1.00
25.41
N


ATOM
12334
CA
ASP
B
276
−59.095
−16.353
−8.979
1.00
25.42
C


ATOM
12336
CB
ASP
B
276
−58.390
−16.794
−7.712
1.00
25.44
C


ATOM
12339
CG
ASP
B
276
−58.728
−15.925
−6.558
1.00
26.32
C


ATOM
12340
OD1
ASP
B
276
−59.302
−14.857
−6.818
1.00
27.50
O


ATOM
12341
OD2
ASP
B
276
−58.442
−16.299
−5.398
1.00
30.16
O


ATOM
12342
C
ASP
B
276
−58.495
−17.069
−10.157
1.00
25.20
C


ATOM
12343
O
ASP
B
276
−57.745
−16.461
−10.929
1.00
25.66
O


ATOM
12345
N
CYS
B
277
−58.814
−18.353
−10.305
1.00
24.60
N


ATOM
12346
CA
CYS
B
277
−58.228
−19.110
−11.391
1.00
24.30
C


ATOM
12348
CB
CYS
B
277
−58.684
−20.561
−11.392
1.00
24.28
C


ATOM
12351
SG
CYS
B
277
−57.737
−21.574
−12.569
1.00
23.82
S


ATOM
12353
C
CYS
B
277
−58.593
−18.448
−12.698
1.00
24.09
C


ATOM
12354
O
CYS
B
277
−57.727
−18.013
−13.450
1.00
23.87
O


ATOM
12356
N
ARG
B
278
−59.893
−18.329
−12.933
1.00
24.22
N


ATOM
12357
CA
ARG
B
278
−60.400
−17.746
−14.171
1.00
23.98
C


ATOM
12359
CB
ARG
B
278
−61.917
−17.556
−14.123
1.00
23.93
C


ATOM
12362
CG
ARG
B
278
−62.662
−18.871
−14.283
1.00
24.07
C


ATOM
12365
CD
ARG
B
278
−64.132
−18.670
−14.607
1.00
24.48
C


ATOM
12368
NE
ARG
B
278
−64.874
−18.141
−13.472
1.00
23.75
N


ATOM
12370
CZ
ARG
B
278
−65.254
−18.856
−12.419
1.00
23.72
C


ATOM
12371
NH1
ARG
B
278
−64.973
−20.149
−12.326
1.00
22.86
N


ATOM
12374
NH2
ARG
B
278
−65.927
−18.262
−11.443
1.00
25.08
N


ATOM
12377
C
ARG
B
278
−59.701
−16.453
−14.491
1.00
23.56
C


ATOM
12378
O
ARG
B
278
−59.296
−16.265
−15.628
1.00
23.87
O


ATOM
12380
N
ASN
B
279
−59.512
−15.593
−13.495
1.00
23.24
N


ATOM
12381
CA
ASN
B
279
−58.854
−14.301
−13.734
1.00
23.48
C


ATOM
12383
CB
ASN
B
279
−59.055
−13.340
−12.574
1.00
24.05
C


ATOM
12386
CG
ASN
B
279
−60.510
−13.017
−12.346
1.00
26.58
C


ATOM
12387
OD1
ASN
B
279
−61.378
−13.310
−13.189
1.00
28.96
O


ATOM
12388
ND2
ASN
B
279
−60.799
−12.416
−11.194
1.00
30.30
N


ATOM
12391
C
ASN
B
279
−57.376
−14.404
−14.027
1.00
22.58
C


ATOM
12392
O
ASN
B
279
−56.903
−13.749
−14.941
1.00
22.73
O


ATOM
12394
N
SER
B
280
−56.648
−15.205
−13.251
1.00
21.62
N


ATOM
12395
CA
SER
B
280
−55.243
−15.483
−13.550
1.00
20.73
C


ATOM
12397
CB
SER
B
280
−54.696
−16.597
−12.659
1.00
20.85
C


ATOM
12400
OG
SER
B
280
−53.805
−16.099
−11.683
1.00
21.55
O


ATOM
12402
C
SER
B
280
−55.091
−15.896
−15.004
1.00
20.04
C


ATOM
12403
O
SER
B
280
−54.293
−15.312
−15.738
1.00
19.87
O


ATOM
12405
N
VAL
B
281
−55.875
−16.893
−15.413
1.00
19.24
N


ATOM
12406
CA
VAL
B
281
−55.720
−17.491
−16.720
1.00
18.77
C


ATOM
12408
CB
VAL
B
281
−56.482
−18.834
−16.815
1.00
18.74
C


ATOM
12410
CG1
VAL
B
281
−56.467
−19.404
−18.251
1.00
18.34
C


ATOM
12414
CG2
VAL
B
281
−55.863
−19.844
−15.848
1.00
18.13
C


ATOM
12418
C
VAL
B
281
−56.142
−16.486
−17.787
1.00
18.89
C


ATOM
12419
O
VAL
B
281
−55.483
−16.364
−18.832
1.00
18.75
O


ATOM
12421
N
ALA
B
282
−57.210
−15.739
−17.505
1.00
18.85
N


ATOM
12422
CA
ALA
B
282
−57.709
−14.723
−18.439
1.00
18.80
C


ATOM
12424
CB
ALA
B
282
−59.051
−14.191
−17.991
1.00
18.32
C


ATOM
12428
C
ALA
B
282
−56.718
−13.576
−18.615
1.00
18.94
C


ATOM
12429
O
ALA
B
282
−56.582
−13.021
−19.700
1.00
19.16
O


ATOM
12431
N
LYS
B
283
−56.022
−13.211
−17.553
1.00
19.24
N


ATOM
12432
CA
LYS
B
283
−55.037
−12.145
−17.658
1.00
19.62
C


ATOM
12434
CB
LYS
B
283
−54.649
−11.615
−16.276
1.00
19.68
C


ATOM
12437
CG
LYS
B
283
−55.779
−10.923
−15.518
1.00
19.95
C


ATOM
12440
CD
LYS
B
283
−55.265
−10.398
−14.196
1.00
21.72
C


ATOM
12443
CE
LYS
B
283
−56.364
−10.236
−13.164
1.00
23.83
C


ATOM
12446
NZ
LYS
B
283
−56.129
−9.003
−12.351
1.00
24.72
N


ATOM
12450
C
LYS
B
283
−53.802
−12.643
−18.396
1.00
19.77
C


ATOM
12451
O
LYS
B
283
−53.237
−11.929
−19.208
1.00
20.05
O


ATOM
12453
N
MET
B
284
−53.387
−13.871
−18.117
1.00
19.88
N


ATOM
12454
CA
MET
B
284
−52.136
−14.367
−18.652
1.00
19.90
C


ATOM
12456
CB
MET
B
284
−51.719
−15.676
−17.960
1.00
20.08
C


ATOM
12459
CG
MET
B
284
−51.125
−15.505
−16.560
1.00
20.62
C


ATOM
12462
SD
MET
B
284
−49.782
−14.295
−16.485
1.00
23.69
S


ATOM
12463
CE
MET
B
284
−50.600
−12.872
−15.754
1.00
23.82
C


ATOM
12467
C
MET
B
284
−52.257
−14.572
−20.145
1.00
19.82
C


ATOM
12468
O
MET
B
284
−51.326
−14.269
−20.889
1.00
20.21
O


ATOM
12470
N
PHE
B
285
−53.401
−15.088
−20.579
1.00
19.72
N


ATOM
12471
CA
PHE
B
285
−53.620
−15.428
−21.986
1.00
19.66
C


ATOM
12473
CB
PHE
B
285
−54.863
−16.324
−22.114
1.00
20.09
C


ATOM
12476
CG
PHE
B
285
−54.986
−17.077
−23.427
1.00
21.18
C


ATOM
12477
CD1
PHE
B
285
−53.877
−17.362
−24.232
1.00
22.86
C


ATOM
12479
CE1
PHE
B
285
−54.013
−18.070
−25.424
1.00
22.58
C


ATOM
12481
CZ
PHE
B
285
−55.254
−18.518
−25.806
1.00
23.49
C


ATOM
12483
CE2
PHE
B
285
−56.365
−18.254
−25.002
1.00
23.36
C


ATOM
12485
CD2
PHE
B
285
−56.222
−17.551
−23.823
1.00
21.76
C


ATOM
12487
C
PHE
B
285
−53.781
−14.148
−22.781
1.00
19.18
C


ATOM
12488
O
PHE
B
285
−53.333
−14.046
−23.914
1.00
18.98
O


ATOM
12490
N
SER
B
286
−54.410
−13.161
−22.164
1.00
18.92
N


ATOM
12491
CA
SER
B
286
−54.488
−11.843
−22.753
1.00
19.15
C


ATOM
12493
CB
SER
B
286
−55.292
−10.894
−21.863
1.00
19.38
C


ATOM
12496
OG
SER
B
286
−56.684
−11.180
−21.957
1.00
20.24
O


ATOM
12498
C
SER
B
286
−53.106
−11.267
−23.032
1.00
18.91
C


ATOM
12499
O
SER
B
286
−52.894
−10.668
−24.087
1.00
19.48
O


ATOM
12501
N
PHE
B
287
−52.172
−11.446
−22.102
1.00
18.48
N


ATOM
12502
CA
PHE
B
287
−50.768
−11.065
−22.339
1.00
18.30
C


ATOM
12504
CB
PHE
B
287
−49.958
−11.035
−21.044
1.00
18.27
C


ATOM
12507
CG
PHE
B
287
−50.040
−9.740
−20.324
1.00
18.59
C


ATOM
12508
CD1
PHE
B
287
−49.375
−8.624
−20.813
1.00
20.02
C


ATOM
12510
CE1
PHE
B
287
−49.456
−7.410
−20.152
1.00
20.57
C


ATOM
12512
CZ
PHE
B
287
−50.208
−7.308
−18.985
1.00
20.02
C


ATOM
12514
CE2
PHE
B
287
−50.869
−8.417
−18.503
1.00
19.78
C


ATOM
12516
CD2
PHE
B
287
−50.781
−9.623
−19.164
1.00
19.05
C


ATOM
12518
C
PHE
B
287
−50.067
−11.978
−23.339
1.00
18.01
C


ATOM
12519
O
PHE
B
287
−49.374
−11.498
−24.229
1.00
18.00
O


ATOM
12521
N
VAL
B
288
−50.236
−13.286
−23.194
1.00
17.69
N


ATOM
12522
CA
VAL
B
288
−49.720
−14.206
−24.197
1.00
17.66
C


ATOM
12524
CB
VAL
B
288
−50.168
−15.649
−23.930
1.00
17.37
C


ATOM
12526
CG1
VAL
B
288
−49.937
−16.529
−25.134
1.00
16.24
C


ATOM
12530
CG2
VAL
B
288
−49.414
−16.185
−22.758
1.00
17.21
C


ATOM
12534
C
VAL
B
288
−50.081
−13.761
−25.633
1.00
18.08
C


ATOM
12535
O
VAL
B
288
−49.207
−13.710
−26.492
1.00
18.08
O


ATOM
12537
N
THR
B
289
−51.327
−13.396
−25.895
1.00
18.42
N


ATOM
12538
CA
THR
B
289
−51.683
−13.001
−27.256
1.00
19.33
C


ATOM
12540
CB
THR
B
289
−53.171
−12.736
−27.401
1.00
19.35
C


ATOM
12542
OG1
THR
B
289
−53.573
−11.895
−26.321
1.00
21.59
O


ATOM
12544
CG2
THR
B
289
−53.973
−14.046
−27.350
1.00
19.09
C


ATOM
12548
C
THR
B
289
−50.901
−11.766
−27.723
1.00
19.71
C


ATOM
12549
O
THR
B
289
−50.469
−11.707
−28.891
1.00
19.88
O


ATOM
12551
N
ILE
B
290
−50.689
−10.796
−26.829
1.00
19.94
N


ATOM
12552
CA
ILE
B
290
−49.943
−9.585
−27.225
1.00
20.39
C


ATOM
12554
CB
ILE
B
290
−50.069
−8.410
−26.221
1.00
20.50
C


ATOM
12556
CG1
ILE
B
290
−51.510
−8.137
−25.823
1.00
21.25
C


ATOM
12559
CD1
ILE
B
290
−51.650
−6.854
−25.002
1.00
21.58
C


ATOM
12563
CG2
ILE
B
290
−49.546
−7.134
−26.853
1.00
20.39
C


ATOM
12567
C
ILE
B
290
−48.434
−9.840
−27.438
1.00
20.45
C


ATOM
12568
O
ILE
B
290
−47.853
−9.317
−28.393
1.00
20.76
O


ATOM
12570
N
ILE
B
291
−47.808
−10.616
−26.546
1.00
20.21
N


ATOM
12571
CA
ILE
B
291
−46.375
−10.869
−26.618
1.00
19.87
C


ATOM
12573
CB
ILE
B
291
−45.840
−11.603
−25.407
1.00
19.79
C


ATOM
12575
CG1
ILE
B
291
−46.205
−10.879
−24.102
1.00
19.71
C


ATOM
12578
CD1
ILE
B
291
−45.326
−9.734
−23.748
1.00
19.77
C


ATOM
12582
CG2
ILE
B
291
−44.336
−11.747
−25.516
1.00
18.91
C


ATOM
12586
C
ILE
B
291
−46.134
−11.735
−27.825
1.00
20.44
C


ATOM
12587
O
ILE
B
291
−45.233
−11.481
−28.600
1.00
20.35
O


ATOM
12589
N
ASP
B
292
−46.965
−12.751
−28.005
1.00
21.33
N


ATOM
12590
CA
ASP
B
292
−46.915
−13.563
−29.228
1.00
22.13
C


ATOM
12592
CB
ASP
B
292
−48.120
−14.508
−29.316
1.00
22.40
C


ATOM
12595
CG
ASP
B
292
−47.847
−15.741
−30.160
1.00
23.47
C


ATOM
12596
OD1
ASP
B
292
−46.852
−15.765
−30.923
1.00
24.83
O


ATOM
12597
OD2
ASP
B
292
−48.637
−16.707
−30.038
1.00
25.22
O


ATOM
12598
C
ASP
B
292
−46.856
−12.716
−30.507
1.00
22.28
C


ATOM
12599
O
ASP
B
292
−46.088
−13.033
−31.399
1.00
22.73
O


ATOM
12601
N
ASP
B
293
−47.656
−11.658
−30.611
1.00
22.22
N


ATOM
12602
CA
ASP
B
293
−47.630
−10.828
−31.822
1.00
22.43
C


ATOM
12604
CB
ASP
B
293
−48.840
−9.894
−31.885
1.00
23.03
C


ATOM
12607
CG
ASP
B
293
−50.157
−10.644
−31.959
1.00
24.69
C


ATOM
12608
OD1
ASP
B
293
−50.113
−11.900
−32.025
1.00
28.66
O


ATOM
12609
OD2
ASP
B
293
−51.231
−9.986
−31.930
1.00
23.57
O


ATOM
12610
C
ASP
B
293
−46.354
−9.997
−31.921
1.00
21.94
C


ATOM
12611
O
ASP
B
293
−45.898
−9.674
−33.019
1.00
22.31
O


ATOM
12613
N
ILE
B
294
−45.783
−9.643
−30.780
1.00
21.05
N


ATOM
12614
CA
ILE
B
294
−44.513
−8.941
−30.770
1.00
20.53
C


ATOM
12616
CB
ILE
B
294
−44.166
−8.448
−29.344
1.00
20.42
C


ATOM
12618
CG1
ILE
B
294
−45.150
−7.349
−28.945
1.00
19.66
C


ATOM
12621
CD1
ILE
B
294
−45.057
−6.956
−27.536
1.00
18.81
C


ATOM
12625
CG2
ILE
B
294
−42.726
−7.924
−29.253
1.00
19.99
C


ATOM
12629
C
ILE
B
294
−43.416
−9.845
−31.343
1.00
20.44
C


ATOM
12630
O
ILE
B
294
−42.650
−9.431
−32.205
1.00
20.17
O


ATOM
12632
N
TYR
B
295
−43.355
−11.088
−30.886
1.00
20.65
N


ATOM
12633
CA
TYR
B
295
−42.313
−12.008
−31.353
1.00
20.76
C


ATOM
12635
CB
TYR
B
295
−42.145
−13.198
−30.412
1.00
20.29
C


ATOM
12638
CG
TYR
B
295
−41.393
−12.926
−29.129
1.00
17.92
C


ATOM
12639
CD1
TYR
B
295
−40.117
−13.409
−28.936
1.00
17.62
C


ATOM
12641
CE1
TYR
B
295
−39.427
−13.195
−27.747
1.00
17.12
C


ATOM
12643
CZ
TYR
B
295
−40.022
−12.493
−26.730
1.00
16.61
C


ATOM
12644
OH
TYR
B
295
−39.357
−12.281
−25.528
1.00
14.46
O


ATOM
12646
CE2
TYR
B
295
−41.296
−12.008
−26.911
1.00
16.82
C


ATOM
12648
CD2
TYR
B
295
−41.972
−12.235
−28.102
1.00
16.39
C


ATOM
12650
C
TYR
B
295
−42.619
−12.519
−32.749
1.00
21.65
C


ATOM
12651
O
TYR
B
295
−41.698
−12.751
−33.540
1.00
22.13
O


ATOM
12653
N
ASP
B
296
−43.905
−12.677
−33.049
1.00
22.47
N


ATOM
12654
CA
ASP
B
296
−44.327
−13.316
−34.285
1.00
23.52
C


ATOM
12656
CB
ASP
B
296
−45.761
−13.851
−34.185
1.00
23.99
C


ATOM
12659
CG
ASP
B
296
−46.134
−14.744
−35.369
1.00
26.22
C


ATOM
12660
OD1
ASP
B
296
−45.508
−15.832
−35.538
1.00
27.70
O


ATOM
12661
OD2
ASP
B
296
−47.052
−14.348
−36.128
1.00
28.78
O


ATOM
12662
C
ASP
B
296
−44.228
−12.392
−35.478
1.00
23.68
C


ATOM
12663
O
ASP
B
296
−43.673
−12.784
−36.502
1.00
24.01
O


ATOM
12665
N
VAL
B
297
−44.765
−11.178
−35.364
1.00
23.90
N


ATOM
12666
CA
VAL
B
297
−44.801
−10.273
−36.524
1.00
23.99
C


ATOM
12668
CB
VAL
B
297
−46.251
−10.003
−36.973
1.00
23.87
C


ATOM
12670
CG1
VAL
B
297
−46.949
−11.310
−37.197
1.00
23.75
C


ATOM
12674
CG2
VAL
B
297
−47.002
−9.136
−35.966
1.00
23.05
C


ATOM
12678
C
VAL
B
297
−44.060
−8.940
−36.383
1.00
24.27
C


ATOM
12679
O
VAL
B
297
−43.485
−8.465
−37.342
1.00
23.84
O


ATOM
12681
N
TYR
B
298
−44.058
−8.347
−35.199
1.00
24.87
N


ATOM
12682
CA
TYR
B
298
−43.760
−6.926
−35.078
1.00
25.67
C


ATOM
12684
CB
TYR
B
298
−44.656
−6.294
−34.010
1.00
26.06
C


ATOM
12687
CG
TYR
B
298
−44.520
−4.789
−33.932
1.00
27.95
C


ATOM
12688
CD1
TYR
B
298
−45.097
−3.968
−34.901
1.00
29.74
C


ATOM
12690
CE1
TYR
B
298
−44.982
−2.574
−34.843
1.00
29.93
C


ATOM
12692
CZ
TYR
B
298
−44.282
−1.991
−33.806
1.00
29.96
C


ATOM
12693
OH
TYR
B
298
−44.165
−.631
−33.746
1.00
30.01
O


ATOM
12695
CE2
TYR
B
298
−43.697
−2.777
−32.829
1.00
30.39
C


ATOM
12697
CD2
TYR
B
298
−43.811
−4.181
−32.899
1.00
29.96
C


ATOM
12699
C
TYR
B
298
−42.318
−6.592
−34.755
1.00
25.76
C


ATOM
12700
O
TYR
B
298
−41.696
−5.830
−35.470
1.00
26.54
O


ATOM
12702
N
GLY
B
299
−41.798
−7.111
−33.653
1.00
25.89
N


ATOM
12703
CA
GLY
B
299
−40.473
−6.706
−33.167
1.00
25.78
C


ATOM
12706
C
GLY
B
299
−39.346
−7.341
−33.951
1.00
25.52
C


ATOM
12707
O
GLY
B
299
−39.513
−8.410
−34.525
1.00
26.04
O


ATOM
12709
N
THR
B
300
−38.196
−6.685
−33.990
1.00
25.32
N


ATOM
12710
CA
THR
B
300
−37.063
−7.237
−34.716
1.00
25.16
C


ATOM
12712
CB
THR
B
300
−36.088
−6.164
−35.295
1.00
25.08
C


ATOM
12714
OG1
THR
B
300
−35.191
−5.710
−34.281
1.00
25.07
O


ATOM
12716
CG2
THR
B
300
−36.833
−4.978
−35.875
1.00
25.08
C


ATOM
12720
C
THR
B
300
−36.324
−8.139
−33.771
1.00
25.13
C


ATOM
12721
O
THR
B
300
−36.335
−7.950
−32.570
1.00
25.28
O


ATOM
12723
N
LEU
B
301
−35.662
−9.129
−34.332
1.00
25.50
N


ATOM
12724
CA
LEU
B
301
−34.918
−10.093
−33.538
1.00
25.42
C


ATOM
12726
CB
LEU
B
301
−34.148
−11.020
−34.479
1.00
25.17
C


ATOM
12729
CG
LEU
B
301
−33.624
−12.338
−33.941
1.00
24.95
C


ATOM
12731
CD1
LEU
B
301
−34.715
−13.233
−33.437
1.00
24.42
C


ATOM
12735
CD2
LEU
B
301
−32.900
−12.998
−35.080
1.00
26.50
C


ATOM
12739
C
LEU
B
301
−33.995
−9.425
−32.485
1.00
25.54
C


ATOM
12740
O
LEU
B
301
−33.843
−9.959
−31.394
1.00
25.35
O


ATOM
12742
N
ASP
B
302
−33.417
−8.257
−32.782
1.00
25.68
N


ATOM
12743
CA
ASP
B
302
−32.598
−7.550
−31.774
1.00
26.02
C


ATOM
12745
CB
ASP
B
302
−31.800
−6.377
−32.378
1.00
26.37
C


ATOM
12748
CG
ASP
B
302
−30.563
−6.833
−33.167
1.00
28.27
C


ATOM
12749
OD1
ASP
B
302
−29.508
−6.156
−33.048
1.00
29.05
O


ATOM
12750
OD2
ASP
B
302
−30.652
−7.852
−33.910
1.00
31.04
O


ATOM
12751
C
ASP
B
302
−33.472
−7.037
−30.630
1.00
25.69
C


ATOM
12752
O
ASP
B
302
−33.110
−7.142
−29.447
1.00
25.90
O


ATOM
12754
N
GLU
B
303
−34.622
−6.473
−30.993
1.00
25.04
N


ATOM
12755
CA
GLU
B
303
−35.600
−6.029
−30.011
1.00
24.33
C


ATOM
12757
CB
GLU
B
303
−36.783
−5.346
−30.697
1.00
24.20
C


ATOM
12760
CG
GLU
B
303
−36.399
−4.109
−31.466
1.00
24.23
C


ATOM
12763
CD
GLU
B
303
−37.589
−3.382
−32.063
1.00
24.23
C


ATOM
12764
OE1
GLU
B
303
−38.496
−4.065
−32.604
1.00
22.66
O


ATOM
12765
OE2
GLU
B
303
−37.592
−2.121
−31.995
1.00
23.93
O


ATOM
12766
C
GLU
B
303
−36.103
−7.212
−29.193
1.00
23.87
C


ATOM
12767
O
GLU
B
303
−36.396
−7.058
−28.011
1.00
23.59
O


ATOM
12769
N
LEU
B
304
−36.204
−8.383
−29.825
1.00
23.39
N


ATOM
12770
CA
LEU
B
304
−36.766
−9.570
−29.166
1.00
23.23
C


ATOM
12772
CB
LEU
B
304
−37.180
−10.624
−30.208
1.00
22.83
C


ATOM
12775
CG
LEU
B
304
−38.381
−10.217
−31.074
1.00
22.06
C


ATOM
12777
CD1
LEU
B
304
−38.822
−11.321
−32.037
1.00
20.11
C


ATOM
12781
CD2
LEU
B
304
−39.551
−9.800
−30.163
1.00
21.94
C


ATOM
12785
C
LEU
B
304
−35.810
−10.147
−28.106
1.00
23.37
C


ATOM
12786
O
LEU
B
304
−36.248
−10.785
−27.141
1.00
23.22
O


ATOM
12788
N
GLU
B
305
−34.514
−9.892
−28.283
1.00
23.30
N


ATOM
12789
CA
GLU
B
305
−33.512
−10.308
−27.324
1.00
23.18
C


ATOM
12791
CB
GLU
B
305
−32.114
−10.176
−27.899
1.00
23.58
C


ATOM
12794
CG
GLU
B
305
−31.832
−11.142
−29.047
1.00
25.27
C


ATOM
12797
CD
GLU
B
305
−31.306
−12.488
−28.585
1.00
27.91
C


ATOM
12798
OE1
GLU
B
305
−30.946
−13.303
−29.470
1.00
29.87
O


ATOM
12799
OE2
GLU
B
305
−31.244
−12.728
−27.351
1.00
29.28
O


ATOM
12800
C
GLU
B
305
−33.633
−9.440
−26.104
1.00
22.52
C


ATOM
12801
O
GLU
B
305
−33.793
−9.956
−25.005
1.00
23.39
O


ATOM
12803
N
LEU
B
306
−33.576
−8.124
−26.274
1.00
21.51
N


ATOM
12804
CA
LEU
B
306
−33.715
−7.224
−25.114
1.00
20.70
C


ATOM
12806
CB
LEU
B
306
−33.899
−5.764
−25.544
1.00
20.59
C


ATOM
12809
CG
LEU
B
306
−32.769
−5.065
−26.293
1.00
20.12
C


ATOM
12811
CD1
LEU
B
306
−32.992
−3.576
−26.203
1.00
19.89
C


ATOM
12815
CD2
LEU
B
306
−31.402
−5.437
−25.739
1.00
19.81
C


ATOM
12819
C
LEU
B
306
−34.896
−7.645
−24.237
1.00
19.91
C


ATOM
12820
O
LEU
B
306
−34.771
−7.778
−23.031
1.00
19.53
O


ATOM
12822
N
PHE
B
307
−36.030
−7.883
−24.872
1.00
19.48
N


ATOM
12823
CA
PHE
B
307
−37.231
−8.267
−24.170
1.00
19.36
C


ATOM
12825
CB
PHE
B
307
−38.400
−8.406
−25.138
1.00
19.54
C


ATOM
12828
CG
PHE
B
307
−39.729
−8.296
−24.482
1.00
19.66
C


ATOM
12829
CD1
PHE
B
307
−40.365
−7.079
−24.400
1.00
21.03
C


ATOM
12831
CE1
PHE
B
307
−41.590
−6.968
−23.787
1.00
21.62
C


ATOM
12833
CZ
PHE
B
307
−42.182
−8.072
−23.248
1.00
20.25
C


ATOM
12835
CE2
PHE
B
307
−41.553
−9.292
−23.329
1.00
20.07
C


ATOM
12837
CD2
PHE
B
307
−40.338
−9.400
−23.939
1.00
19.62
C


ATOM
12839
C
PHE
B
307
−37.039
−9.577
−23.443
1.00
19.22
C


ATOM
12840
O
PHE
B
307
−37.354
−9.684
−22.260
1.00
19.50
O


ATOM
12842
N
THR
B
308
−36.532
−10.583
−24.143
1.00
18.96
N


ATOM
12843
CA
THR
B
308
−36.321
−11.874
−23.511
1.00
18.84
C


ATOM
12845
CB
THR
B
308
−35.774
−12.879
−24.490
1.00
18.62
C


ATOM
12847
OG1
THR
B
308
−36.687
−12.988
−25.579
1.00
18.88
O


ATOM
12849
CG2
THR
B
308
−35.626
−14.228
−23.833
1.00
18.74
C


ATOM
12853
C
THR
B
308
−35.384
−11.737
−22.317
1.00
19.04
C


ATOM
12854
O
THR
B
308
−35.686
−12.244
−21.233
1.00
18.69
O


ATOM
12856
N
ASP
B
309
−34.264
−11.031
−22.511
1.00
19.36
N


ATOM
12857
CA
ASP
B
309
−33.335
−10.751
−21.421
1.00
19.65
C


ATOM
12859
CB
ASP
B
309
−32.121
−9.983
−21.942
1.00
19.92
C


ATOM
12862
CG
ASP
B
309
−31.171
−9.536
−20.814
1.00
23.51
C


ATOM
12863
OD1
ASP
B
309
−30.520
−10.412
−20.175
1.00
27.27
O


ATOM
12864
OD2
ASP
B
309
−31.076
−8.299
−20.561
1.00
27.40
O


ATOM
12865
C
ASP
B
309
−34.048
−9.977
−20.295
1.00
19.08
C


ATOM
12866
O
ASP
B
309
−33.912
−10.308
−19.124
1.00
18.55
O


ATOM
12868
N
ALA
B
310
−34.836
−8.975
−20.665
1.00
18.93
N


ATOM
12869
CA
ALA
B
310
−35.546
−8.151
−19.688
1.00
19.12
C


ATOM
12871
CB
ALA
B
310
−36.346
−7.062
−20.380
1.00
18.79
C


ATOM
12875
C
ALA
B
310
−36.462
−8.965
−18.784
1.00
19.36
C


ATOM
12876
O
ALA
B
310
−36.560
−8.696
−17.577
1.00
19.58
O


ATOM
12878
N
VAL
B
311
−37.143
−9.942
−19.370
1.00
19.61
N


ATOM
12879
CA
VAL
B
311
−37.996
−10.845
−18.611
1.00
19.68
C


ATOM
12881
CB
VAL
B
311
−38.867
−11.682
−19.555
1.00
19.46
C


ATOM
12883
CG1
VAL
B
311
−39.948
−10.825
−20.123
1.00
18.49
C


ATOM
12887
CG2
VAL
B
311
−39.469
−12.863
−18.843
1.00
19.31
C


ATOM
12891
C
VAL
B
311
−37.161
−11.726
−17.673
1.00
20.46
C


ATOM
12892
O
VAL
B
311
−37.479
−11.843
−16.494
1.00
20.25
O


ATOM
12894
N
GLU
B
312
−36.085
−12.317
−18.189
1.00
21.67
N


ATOM
12895
CA
GLU
B
312
−35.198
−13.168
−17.384
1.00
22.65
C


ATOM
12897
CB
GLU
B
312
−34.056
−13.708
−18.239
1.00
23.03
C


ATOM
12900
CG
GLU
B
312
−34.454
−14.764
−19.261
1.00
24.88
C


ATOM
12903
CD
GLU
B
312
−33.335
−15.077
−20.267
1.00
27.34
C


ATOM
12904
OE1
GLU
B
312
−33.485
−16.057
−21.028
1.00
29.07
O


ATOM
12905
OE2
GLU
B
312
−32.316
−14.342
−20.313
1.00
28.63
O


ATOM
12906
C
GLU
B
312
−34.598
−12.443
−16.167
1.00
23.09
C


ATOM
12907
O
GLU
B
312
−34.506
−13.007
−15.082
1.00
23.04
O


ATOM
12909
N
ARG
B
313
−34.186
−11.199
−16.335
1.00
23.67
N


ATOM
12910
CA
ARG
B
313
−33.590
−10.486
−15.222
1.00
24.60
C


ATOM
12912
CB
ARG
B
313
−32.609
−9.436
−15.735
1.00
25.26
C


ATOM
12915
CG
ARG
B
313
−31.333
−10.030
−16.398
1.00
27.83
C


ATOM
12918
CD
ARG
B
313
−30.289
−8.943
−16.754
1.00
31.87
C


ATOM
12921
NE
ARG
B
313
−30.922
−7.793
−17.430
1.00
35.71
N


ATOM
12923
CZ
ARG
B
313
−31.341
−6.661
−16.837
1.00
38.42
C


ATOM
12924
NH1
ARG
B
313
−31.189
−6.452
−15.522
1.00
39.15
N


ATOM
12927
NH2
ARG
B
313
−31.919
−5.711
−17.576
1.00
39.25
N


ATOM
12930
C
ARG
B
313
−34.638
−9.879
−14.280
1.00
24.67
C


ATOM
12931
O
ARG
B
313
−34.359
−9.645
−13.117
1.00
24.09
O


ATOM
12933
N
TRP
B
314
−35.843
−9.635
−14.781
1.00
25.60
N


ATOM
12934
CA
TRP
B
314
−36.971
−9.180
−13.951
1.00
26.20
C


ATOM
12936
CB
TRP
B
314
−37.488
−10.339
−13.097
1.00
25.90
C


ATOM
12939
CG
TRP
B
314
−38.912
−10.184
−12.662
1.00
23.93
C


ATOM
12940
CD1
TRP
B
314
−39.355
−9.854
−11.424
1.00
22.76
C


ATOM
12942
NE1
TRP
B
314
−40.727
−9.804
−11.412
1.00
21.93
N


ATOM
12944
CE2
TRP
B
314
−41.189
−10.107
−12.659
1.00
20.38
C


ATOM
12945
CD2
TRP
B
314
−40.074
−10.352
−13.473
1.00
21.17
C


ATOM
12946
CE3
TRP
B
314
−40.277
−10.684
−14.811
1.00
20.19
C


ATOM
12948
CZ3
TRP
B
314
−41.549
−10.766
−15.280
1.00
19.79
C


ATOM
12950
CH2
TRP
B
314
−42.640
−10.512
−14.445
1.00
21.00
C


ATOM
12952
CZ2
TRP
B
314
−42.474
−10.179
−13.130
1.00
20.60
C


ATOM
12954
C
TRP
B
314
−36.620
−7.966
−13.076
1.00
27.57
C


ATOM
12955
O
TRP
B
314
−36.890
−7.935
−11.870
1.00
27.56
O


ATOM
12957
N
ASP
B
315
−36.039
−6.959
−13.718
1.00
29.12
N


ATOM
12958
CA
ASP
B
315
−35.452
−5.822
−13.027
1.00
30.46
C


ATOM
12960
CB
ASP
B
315
−33.935
−5.796
−13.315
1.00
30.84
C


ATOM
12963
CG
ASP
B
315
−33.227
−4.551
−12.772
1.00
32.75
C


ATOM
12964
OD1
ASP
B
315
−33.747
−3.904
−11.830
1.00
35.67
O


ATOM
12965
OD2
ASP
B
315
−32.128
−4.222
−13.295
1.00
34.91
O


ATOM
12966
C
ASP
B
315
−36.157
−4.592
−13.557
1.00
31.10
C


ATOM
12967
O
ASP
B
315
−35.888
−4.157
−14.674
1.00
31.35
O


ATOM
12969
N
VAL
B
316
−37.088
−4.044
−12.781
1.00
32.06
N


ATOM
12970
CA
VAL
B
316
−37.864
−2.896
−13.262
1.00
32.65
C


ATOM
12972
CB
VAL
B
316
−39.016
−2.510
−12.334
1.00
32.45
C


ATOM
12974
CG1
VAL
B
316
−39.911
−1.499
−13.012
1.00
32.15
C


ATOM
12978
CG2
VAL
B
316
−38.490
−1.960
−11.040
1.00
32.91
C


ATOM
12982
C
VAL
B
316
−36.964
−1.692
−13.442
1.00
33.43
C


ATOM
12983
O
VAL
B
316
−37.228
−.854
−14.294
1.00
33.74
O


ATOM
12985
N
ASN
B
317
−35.881
−1.628
−12.663
1.00
34.29
N


ATOM
12986
CA
ASN
B
317
−34.937
−.510
−12.730
1.00
34.63
C


ATOM
12988
CB
ASN
B
317
−33.995
−.526
−11.505
1.00
34.50
C


ATOM
12991
CG
ASN
B
317
−34.692
−.084
−10.201
1.00
34.08
C


ATOM
12992
OD1
ASN
B
317
−35.198
1.042
−10.104
1.00
33.72
O


ATOM
12993
ND2
ASN
B
317
−34.690
−.961
−9.193
1.00
31.22
N


ATOM
12996
C
ASN
B
317
−34.124
−.481
−14.029
1.00
35.21
C


ATOM
12997
O
ASN
B
317
−33.196
.296
−14.127
1.00
35.52
O


ATOM
12999
N
ALA
B
318
−34.470
−1.318
−15.013
1.00
35.89
N


ATOM
13000
CA
ALA
B
318
−33.757
−1.382
−16.299
1.00
36.48
C


ATOM
13002
CB
ALA
B
318
−32.727
−2.508
−16.253
1.00
36.49
C


ATOM
13006
C
ALA
B
318
−34.695
−1.525
−17.534
1.00
37.02
C


ATOM
13007
O
ALA
B
318
−34.297
−1.984
−18.616
1.00
36.52
O


ATOM
13009
N
ILE
B
319
−35.952
−1.137
−17.339
1.00
37.76
N


ATOM
13010
CA
ILE
B
319
−36.848
−.733
−18.424
1.00
38.08
C


ATOM
13012
CB
ILE
B
319
−37.926
.247
−17.893
1.00
38.11
C


ATOM
13014
CG1
ILE
B
319
−39.110
−.495
−17.293
1.00
38.08
C


ATOM
13017
CD1
ILE
B
319
−40.068
.451
−16.596
1.00
38.27
C


ATOM
13021
CG2
ILE
B
319
−38.408
1.189
−18.996
1.00
37.84
C


ATOM
13025
C
ILE
B
319
−36.134
.053
−19.516
1.00
38.29
C


ATOM
13026
O
ILE
B
319
−36.192
−.324
−20.677
1.00
38.68
O


ATOM
13028
N
ASN
B
320
−35.460
1.141
−19.125
1.00
38.36
N


ATOM
13029
CA
ASN
B
320
−34.977
2.168
−20.074
1.00
38.17
C


ATOM
13031
CB
ASN
B
320
−34.278
3.331
−19.331
1.00
38.16
C


ATOM
13034
CG
ASN
B
320
−35.258
4.207
−18.514
1.00
37.87
C


ATOM
13035
OD1
ASN
B
320
−36.366
4.542
−18.955
1.00
36.50
O


ATOM
13036
ND2
ASN
B
320
−34.827
4.589
−17.322
1.00
38.12
N


ATOM
13039
C
ASN
B
320
−34.082
1.643
−21.206
1.00
37.78
C


ATOM
13040
O
ASN
B
320
−33.856
2.332
−22.181
1.00
37.76
O


ATOM
13042
N
ASP
B
321
−33.600
.416
−21.083
1.00
37.46
N


ATOM
13043
CA
ASP
B
321
−32.852
−.224
−22.162
1.00
37.25
C


ATOM
13045
CB
ASP
B
321
−32.091
−1.467
−21.629
1.00
37.83
C


ATOM
13048
CG
ASP
B
321
−31.351
−1.207
−20.285
1.00
39.33
C


ATOM
13049
OD1
ASP
B
321
−31.247
−.021
−19.871
1.00
40.72
O


ATOM
13050
OD2
ASP
B
321
−30.887
−2.199
−19.648
1.00
39.62
O


ATOM
13051
C
ASP
B
321
−33.764
−.636
−23.339
1.00
35.99
C


ATOM
13052
O
ASP
B
321
−33.273
−.904
−24.436
1.00
35.87
O


ATOM
13054
N
LEU
B
322
−35.076
−.674
−23.111
1.00
34.66
N


ATOM
13055
CA
LEU
B
322
−36.024
−1.263
−24.061
1.00
33.77
C


ATOM
13057
CB
LEU
B
322
−37.180
−1.961
−23.327
1.00
33.65
C


ATOM
13060
CG
LEU
B
322
−36.994
−3.260
−22.544
1.00
32.41
C


ATOM
13062
CD1
LEU
B
322
−38.223
−3.482
−21.693
1.00
31.54
C


ATOM
13066
CD2
LEU
B
322
−36.769
−4.432
−23.460
1.00
30.73
C


ATOM
13070
C
LEU
B
322
−36.670
−.243
−24.982
1.00
33.32
C


ATOM
13071
O
LEU
B
322
−36.910
.893
−24.570
1.00
33.37
O


ATOM
13073
N
PRO
B
323
−37.005
−.667
−26.218
1.00
32.72
N


ATOM
13074
CA
PRO
B
323
−37.856
.068
−27.126
1.00
32.42
C


ATOM
13076
CB
PRO
B
323
−38.239
−.985
−28.158
1.00
32.28
C


ATOM
13079
CG
PRO
B
323
−37.098
−1.849
−28.231
1.00
32.46
C


ATOM
13082
CD
PRO
B
323
−36.498
−1.891
−26.857
1.00
32.79
C


ATOM
13085
C
PRO
B
323
−39.115
.576
−26.453
1.00
32.50
C


ATOM
13086
O
PRO
B
323
−39.655
−.083
−25.550
1.00
32.46
O


ATOM
13087
N
ASP
B
324
−39.590
1.725
−26.923
1.00
32.44
N


ATOM
13088
CA
ASP
B
324
−40.729
2.387
−26.318
1.00
32.44
C


ATOM
13090
CB
ASP
B
324
−41.059
3.678
−27.071
1.00
32.91
C


ATOM
13093
CG
ASP
B
324
−40.241
4.873
−26.576
1.00
34.17
C


ATOM
13094
OD1
ASP
B
324
−39.507
4.728
−25.562
1.00
35.83
O


ATOM
13095
OD2
ASP
B
324
−40.351
5.960
−27.196
1.00
35.42
O


ATOM
13096
C
ASP
B
324
−41.967
1.504
−26.186
1.00
31.78
C


ATOM
13097
O
ASP
B
324
−42.546
1.440
−25.102
1.00
31.77
O


ATOM
13099
N
TYR
B
325
−42.368
.821
−27.258
1.00
30.99
N


ATOM
13100
CA
TYR
B
325
−43.519
−.086
−27.167
1.00
30.49
C


ATOM
13102
CB
TYR
B
325
−43.941
−.640
−28.536
1.00
30.28
C


ATOM
13105
CG
TYR
B
325
−43.027
−1.688
−29.134
1.00
30.25
C


ATOM
13106
CD1
TYR
B
325
−41.917
−1.332
−29.893
1.00
29.81
C


ATOM
13108
CE1
TYR
B
325
−41.089
−2.300
−30.449
1.00
29.74
C


ATOM
13110
CZ
TYR
B
325
−41.371
−3.643
−30.258
1.00
30.22
C


ATOM
13111
OH
TYR
B
325
−40.565
−4.625
−30.805
1.00
31.28
O


ATOM
13113
CE2
TYR
B
325
−42.466
−4.015
−29.519
1.00
30.23
C


ATOM
13115
CD2
TYR
B
325
−43.288
−3.038
−28.963
1.00
30.49
C


ATOM
13117
C
TYR
B
325
−43.284
−1.221
−26.168
1.00
30.14
C


ATOM
13118
O
TYR
B
325
−44.219
−1.638
−25.483
1.00
30.19
O


ATOM
13120
N
MET
B
326
−42.048
−1.700
−26.060
1.00
29.74
N


ATOM
13121
CA
MET
B
326
−41.755
−2.820
−25.155
1.00
29.82
C


ATOM
13123
CB
MET
B
326
−40.461
−3.541
−25.549
1.00
29.69
C


ATOM
13126
CG
MET
B
326
−40.650
−4.510
−26.686
1.00
28.83
C


ATOM
13129
SD
MET
B
326
−39.123
−5.272
−27.204
1.00
26.99
S


ATOM
13130
CE
MET
B
326
−39.761
−6.499
−28.328
1.00
29.13
C


ATOM
13134
C
MET
B
326
−41.696
−2.402
−23.683
1.00
29.92
C


ATOM
13135
O
MET
B
326
−42.032
−3.204
−22.801
1.00
29.75
O


ATOM
13137
N
LYS
B
327
−41.251
−1.166
−23.429
1.00
29.68
N


ATOM
13138
CA
LYS
B
327
−41.318
−.578
−22.088
1.00
29.46
C


ATOM
13140
CB
LYS
B
327
−41.016
.921
−22.114
1.00
29.93
C


ATOM
13143
CG
LYS
B
327
−39.572
1.305
−21.951
1.00
31.63
C


ATOM
13146
CD
LYS
B
327
−39.410
2.803
−22.249
1.00
34.93
C


ATOM
13149
CE
LYS
B
327
−37.986
3.291
−22.021
1.00
36.86
C


ATOM
13152
NZ
LYS
B
327
−37.642
4.436
−22.917
1.00
37.83
N


ATOM
13156
C
LYS
B
327
−42.708
−.752
−21.531
1.00
28.46
C


ATOM
13157
O
LYS
B
327
−42.879
−1.314
−20.461
1.00
28.54
O


ATOM
13159
N
LEU
B
328
−43.696
−.258
−22.268
1.00
27.39
N


ATOM
13160
CA
LEU
B
328
−45.056
−.216
−21.785
1.00
26.79
C


ATOM
13162
CB
LEU
B
328
−45.946
.519
−22.773
1.00
26.68
C


ATOM
13165
CG
LEU
B
328
−47.265
1.034
−22.212
1.00
26.00
C


ATOM
13167
CD1
LEU
B
328
−47.010
1.964
−21.036
1.00
24.88
C


ATOM
13171
CD2
LEU
B
328
−48.051
1.740
−23.308
1.00
24.55
C


ATOM
13175
C
LEU
B
328
−45.560
−1.628
−21.587
1.00
26.70
C


ATOM
13176
O
LEU
B
328
−46.110
−1.983
−20.543
1.00
27.03
O


ATOM
13178
N
CYS
B
329
−45.341
−2.453
−22.591
1.00
26.39
N


ATOM
13179
CA
CYS
B
329
−45.750
−3.843
−22.524
1.00
26.12
C


ATOM
13181
CB
CYS
B
329
−45.382
−4.526
−23.838
1.00
26.47
C


ATOM
13184
SG
CYS
B
329
−45.857
−6.236
−23.880
1.00
30.60
S


ATOM
13186
C
CYS
B
329
−45.124
−4.568
−21.319
1.00
24.45
C


ATOM
13187
O
CYS
B
329
−45.829
−5.105
−20.486
1.00
23.93
O


ATOM
13189
N
PHE
B
330
−43.801
−4.553
−21.228
1.00
23.30
N


ATOM
13190
CA
PHE
B
330
−43.087
−5.220
−20.141
1.00
22.47
C


ATOM
13192
CB
PHE
B
330
−41.575
−5.019
−20.267
1.00
22.42
C


ATOM
13195
CG
PHE
B
330
−40.800
−5.518
−19.076
1.00
22.37
C


ATOM
13196
CD1
PHE
B
330
−40.502
−6.864
−18.940
1.00
22.47
C


ATOM
13198
CE1
PHE
B
330
−39.799
−7.339
−17.836
1.00
21.64
C


ATOM
13200
CZ
PHE
B
330
−39.379
−6.472
−16.866
1.00
21.50
C


ATOM
13202
CE2
PHE
B
330
−39.659
−5.122
−16.983
1.00
21.92
C


ATOM
13204
CD2
PHE
B
330
−40.374
−4.648
−18.084
1.00
22.29
C


ATOM
13206
C
PHE
B
330
−43.524
−4.739
−18.765
1.00
21.87
C


ATOM
13207
O
PHE
B
330
−43.779
−5.552
−17.875
1.00
21.98
O


ATOM
13209
N
LEU
B
331
−43.594
−3.427
−18.573
1.00
20.88
N


ATOM
13210
CA
LEU
B
331
−43.997
−2.894
−17.276
1.00
20.25
C


ATOM
13212
CB
LEU
B
331
−43.927
−1.354
−17.257
1.00
20.06
C


ATOM
13215
CG
LEU
B
331
−44.124
−.628
−15.912
1.00
19.21
C


ATOM
13217
CD1
LEU
B
331
−43.542
−1.408
−14.737
1.00
18.78
C


ATOM
13221
CD2
LEU
B
331
−43.555
.770
−15.957
1.00
15.75
C


ATOM
13225
C
LEU
B
331
−45.398
−3.408
−16.902
1.00
19.99
C


ATOM
13226
O
LEU
B
331
−45.606
−3.860
−15.771
1.00
19.67
O


ATOM
13228
N
ALA
B
332
−46.336
−3.373
−17.860
1.00
19.56
N


ATOM
13229
CA
ALA
B
332
−47.695
−3.882
−17.629
1.00
19.24
C


ATOM
13231
CB
ALA
B
332
−48.528
−3.802
−18.891
1.00
18.58
C


ATOM
13235
C
ALA
B
332
−47.637
−5.321
−17.108
1.00
19.23
C


ATOM
13236
O
ALA
B
332
−48.235
−5.650
−16.079
1.00
19.18
O


ATOM
13238
N
LEU
B
333
−46.891
−6.162
−17.816
1.00
19.16
N


ATOM
13239
CA
LEU
B
333
−46.727
−7.554
−17.438
1.00
19.08
C


ATOM
13241
CB
LEU
B
333
−45.830
−8.260
−18.462
1.00
18.97
C


ATOM
13244
CG
LEU
B
333
−45.511
−9.758
−18.307
1.00
19.18
C


ATOM
13246
CD1
LEU
B
333
−46.779
−10.611
−18.121
1.00
18.09
C


ATOM
13250
CD2
LEU
B
333
−44.676
−10.262
−19.499
1.00
17.17
C


ATOM
13254
C
LEU
B
333
−46.111
−7.616
−16.042
1.00
19.16
C


ATOM
13255
O
LEU
B
333
−46.629
−8.279
−15.137
1.00
18.97
O


ATOM
13257
N
TYR
B
334
−45.013
−6.887
−15.884
1.00
19.23
N


ATOM
13258
CA
TYR
B
334
−44.212
−6.906
−14.664
1.00
19.33
C


ATOM
13260
CB
TYR
B
334
−43.092
−5.873
−14.785
1.00
19.43
C


ATOM
13263
CG
TYR
B
334
−42.190
−5.748
−13.596
1.00
19.44
C


ATOM
13264
CD1
TYR
B
334
−41.006
−6.464
−13.524
1.00
20.60
C


ATOM
13266
CE1
TYR
B
334
−40.148
−6.347
−12.442
1.00
20.77
C


ATOM
13268
CZ
TYR
B
334
−40.474
−5.503
−11.417
1.00
21.51
C


ATOM
13269
OH
TYR
B
334
−39.628
−5.387
−10.353
1.00
21.42
O


ATOM
13271
CE2
TYR
B
334
−41.646
−4.768
−11.466
1.00
22.15
C


ATOM
13273
CD2
TYR
B
334
−42.495
−4.892
−12.565
1.00
20.55
C


ATOM
13275
C
TYR
B
334
−45.065
−6.614
−13.443
1.00
19.37
C


ATOM
13276
O
TYR
B
334
−44.980
−7.337
−12.441
1.00
19.94
O


ATOM
13278
N
ASN
B
335
−45.888
−5.565
−13.527
1.00
18.83
N


ATOM
13279
CA
ASN
B
335
−46.784
−5.236
−12.443
1.00
18.37
C


ATOM
13281
CB
ASN
B
335
−47.452
−3.896
−12.675
1.00
18.52
C


ATOM
13284
CG
ASN
B
335
−46.493
−2.742
−12.518
1.00
19.27
C


ATOM
13285
OD1
ASN
B
335
−45.421
−2.906
−11.953
1.00
21.25
O


ATOM
13286
ND2
ASN
B
335
−46.872
−1.566
−13.022
1.00
19.24
N


ATOM
13289
C
ASN
B
335
−47.812
−6.333
−12.291
1.00
18.22
C


ATOM
13290
O
ASN
B
335
−47.966
−6.891
−11.207
1.00
18.53
O


ATOM
13292
N
THR
B
336
−48.481
−6.697
−13.379
1.00
17.95
N


ATOM
13293
CA
THR
B
336
−49.525
−7.728
−13.301
1.00
17.61
C


ATOM
13295
CB
THR
B
336
−49.980
−8.204
−14.676
1.00
17.36
C


ATOM
13297
OG1
THR
B
336
−50.249
−7.065
−15.500
1.00
17.02
O


ATOM
13299
CG2
THR
B
336
−51.228
−9.044
−14.551
1.00
16.07
C


ATOM
13303
C
THR
B
336
−49.065
−8.941
−12.501
1.00
17.75
C


ATOM
13304
O
THR
B
336
−49.788
−9.429
−11.621
1.00
18.09
O


ATOM
13306
N
ILE
B
337
−47.859
−9.411
−12.785
1.00
17.69
N


ATOM
13307
CA
ILE
B
337
−47.384
−10.630
−12.165
1.00
17.74
C


ATOM
13309
CB
ILE
B
337
−46.228
−11.245
−12.949
1.00
17.40
C


ATOM
13311
CG1
ILE
B
337
−46.795
−11.865
−14.227
1.00
18.44
C


ATOM
13314
CD1
ILE
B
337
−45.767
−12.192
−15.300
1.00
19.26
C


ATOM
13318
CG2
ILE
B
337
−45.568
−12.320
−12.152
1.00
16.25
C


ATOM
13322
C
ILE
B
337
−47.053
−10.395
−10.699
1.00
18.32
C


ATOM
13323
O
ILE
B
337
−47.497
−11.175
−9.838
1.00
18.06
O


ATOM
13325
N
ASN
B
338
−46.321
−9.311
−10.404
1.00
18.89
N


ATOM
13326
CA
ASN
B
338
−45.985
−8.978
−9.007
1.00
19.49
C


ATOM
13328
CB
ASN
B
338
−45.189
−7.690
−8.917
1.00
19.43
C


ATOM
13331
CG
ASN
B
338
−43.789
−7.836
−9.444
1.00
20.83
C


ATOM
13332
OD1
ASN
B
338
−43.292
−8.954
−9.634
1.00
21.52
O


ATOM
13333
ND2
ASN
B
338
−43.124
−6.697
−9.676
1.00
22.32
N


ATOM
13336
C
ASN
B
338
−47.229
−8.835
−8.146
1.00
20.05
C


ATOM
13337
O
ASN
B
338
−47.182
−9.055
−6.953
1.00
19.81
O


ATOM
13339
N
GLU
B
339
−48.337
−8.459
−8.770
1.00
20.81
N


ATOM
13340
CA
GLU
B
339
−49.589
−8.347
−8.086
1.00
21.81
C


ATOM
13342
CB
GLU
B
339
−50.563
−7.544
−8.933
1.00
22.69
C


ATOM
13345
CG
GLU
B
339
−51.240
−6.422
−8.148
1.00
27.28
C


ATOM
13348
CD
GLU
B
339
−52.571
−5.959
−8.768
1.00
32.79
C


ATOM
13349
OE1
GLU
B
339
−52.761
−4.713
−8.897
1.00
36.20
O


ATOM
13350
OE2
GLU
B
339
−53.416
−6.837
−9.114
1.00
34.35
O


ATOM
13351
C
GLU
B
339
−50.170
−9.732
−7.762
1.00
21.59
C


ATOM
13352
O
GLU
B
339
−50.690
−9.946
−6.666
1.00
21.38
O


ATOM
13354
N
ILE
B
340
−50.094
−10.676
−8.700
1.00
21.48
N


ATOM
13355
CA
ILE
B
340
−50.486
−12.049
−8.384
1.00
21.27
C


ATOM
13357
CB
ILE
B
340
−50.437
−12.990
−9.603
1.00
21.17
C


ATOM
13359
CG1
ILE
B
340
−51.478
−12.589
−10.643
1.00
20.99
C


ATOM
13362
CD1
ILE
B
340
−51.245
−13.202
−12.017
1.00
19.72
C


ATOM
13366
CG2
ILE
B
340
−50.702
−14.444
−9.177
1.00
21.09
C


ATOM
13370
C
ILE
B
340
−49.557
−12.585
−7.278
1.00
21.40
C


ATOM
13371
O
ILE
B
340
−50.023
−13.238
−6.334
1.00
21.74
O


ATOM
13373
N
ALA
B
341
−48.256
−12.301
−7.380
1.00
20.90
N


ATOM
13374
CA
ALA
B
341
−47.312
−12.721
−6.349
1.00
20.62
C


ATOM
13376
CB
ALA
B
341
−45.922
−12.260
−6.694
1.00
20.53
C


ATOM
13380
C
ALA
B
341
−47.720
−12.195
−4.969
1.00
20.59
C


ATOM
13381
O
ALA
B
341
−47.606
−12.901
−3.950
1.00
20.57
O


ATOM
13383
N
TYR
B
342
−48.208
−10.958
−4.949
1.00
20.62
N


ATOM
13384
CA
TYR
B
342
−48.600
−10.303
−3.707
1.00
20.59
C


ATOM
13386
CB
TYR
B
342
−48.790
−8.792
−3.907
1.00
20.05
C


ATOM
13389
CG
TYR
B
342
−49.309
−8.143
−2.674
1.00
18.29
C


ATOM
13390
CD1
TYR
B
342
−48.443
−7.683
−1.698
1.00
17.62
C


ATOM
13392
CE1
TYR
B
342
−48.914
−7.111
−.518
1.00
17.91
C


ATOM
13394
CZ
TYR
B
342
−50.285
−7.005
−.298
1.00
18.18
C


ATOM
13395
OH
TYR
B
342
−50.763
−6.433
.877
1.00
16.00
O


ATOM
13397
CE2
TYR
B
342
−51.169
−7.467
−1.275
1.00
18.10
C


ATOM
13399
CD2
TYR
B
342
−50.670
−8.037
−2.450
1.00
17.67
C


ATOM
13401
C
TYR
B
342
−49.863
−10.928
−3.118
1.00
21.48
C


ATOM
13402
O
TYR
B
342
−49.960
−11.089
−1.913
1.00
20.91
O


ATOM
13404
N
ASP
B
343
−50.832
−11.273
−3.959
1.00
22.93
N


ATOM
13405
CA
ASP
B
343
−52.048
−11.925
−3.470
1.00
24.30
C


ATOM
13407
CB
ASP
B
343
−53.010
−12.282
−4.608
1.00
24.59
C


ATOM
13410
CG
ASP
B
343
−53.577
−11.060
−5.334
1.00
26.66
C


ATOM
13411
OD1
ASP
B
343
−53.619
−9.936
−4.756
1.00
28.24
O


ATOM
13412
OD2
ASP
B
343
−54.004
−11.247
−6.506
1.00
29.56
O


ATOM
13413
C
ASP
B
343
−51.660
−13.208
−2.761
1.00
24.97
C


ATOM
13414
O
ASP
B
343
−52.128
−13.495
−1.658
1.00
24.95
O


ATOM
13416
N
ASN
B
344
−50.792
−13.973
−3.413
1.00
25.90
N


ATOM
13417
CA
ASN
B
344
−50.322
−15.252
−2.884
1.00
26.59
C


ATOM
13419
CB
ASN
B
344
−49.623
−16.043
−3.978
1.00
26.74
C


ATOM
13422
CG
ASN
B
344
−50.594
−16.639
−4.933
1.00
28.21
C


ATOM
13423
OD1
ASN
B
344
−51.080
−17.737
−4.688
1.00
32.10
O


ATOM
13424
ND2
ASN
B
344
−50.923
−15.916
−6.016
1.00
28.40
N


ATOM
13427
C
ASN
B
344
−49.421
−15.146
−1.655
1.00
26.78
C


ATOM
13428
O
ASN
B
344
−49.424
−16.053
−.821
1.00
27.06
O


ATOM
13430
N
LEU
B
345
−48.647
−14.067
−1.533
1.00
26.74
N


ATOM
13431
CA
LEU
B
345
−47.970
−13.793
−.261
1.00
26.59
C


ATOM
13433
CB
LEU
B
345
−47.005
−12.618
−.396
1.00
26.25
C


ATOM
13436
CG
LEU
B
345
−46.046
−12.376
.764
1.00
24.65
C


ATOM
13438
CD1
LEU
B
345
−45.258
−13.621
1.115
1.00
22.50
C


ATOM
13442
CD2
LEU
B
345
−45.119
−11.251
.387
1.00
23.54
C


ATOM
13446
C
LEU
B
345
−49.004
−13.503
.840
1.00
27.00
C


ATOM
13447
O
LEU
B
345
−48.903
−14.014
1.947
1.00
26.93
O


ATOM
13449
N
LYS
B
346
−50.008
−12.697
.518
1.00
27.54
N


ATOM
13450
CA
LYS
B
346
−51.012
−12.300
1.491
1.00
27.96
C


ATOM
13452
CB
LYS
B
346
−51.998
−11.288
.889
1.00
28.13
C


ATOM
13455
CG
LYS
B
346
−52.822
−10.527
1.926
1.00
28.70
C


ATOM
13458
CD
LYS
B
346
−53.781
−9.526
1.281
1.00
29.73
C


ATOM
13461
CE
LYS
B
346
−55.205
−10.063
1.133
1.00
31.17
C


ATOM
13464
NZ
LYS
B
346
−55.839
−9.661
−.171
1.00
32.83
N


ATOM
13468
C
LYS
B
346
−51.788
−13.498
1.984
1.00
28.31
C


ATOM
13469
O
LYS
B
346
−52.074
−13.600
3.177
1.00
28.52
O


ATOM
13471
N
ASP
B
347
−52.149
−14.396
1.075
1.00
28.56
N


ATOM
13472
CA
ASP
B
347
−53.102
−15.441
1.427
1.00
29.11
C


ATOM
13474
CB
ASP
B
347
−54.068
−15.736
.268
1.00
29.50
C


ATOM
13477
CG
ASP
B
347
−54.902
−14.500
−.150
1.00
31.04
C


ATOM
13478
OD1
ASP
B
347
−54.961
−13.500
.616
1.00
31.35
O


ATOM
13479
OD2
ASP
B
347
−55.496
−14.534
−1.261
1.00
33.39
O


ATOM
13480
C
ASP
B
347
−52.403
−16.699
1.891
1.00
28.79
C


ATOM
13481
O
ASP
B
347
−52.824
−17.321
2.854
1.00
29.02
O


ATOM
13483
N
LYS
B
348
−51.326
−17.068
1.222
1.00
28.74
N


ATOM
13484
CA
LYS
B
348
−50.612
−18.293
1.564
1.00
28.84
C


ATOM
13486
CB
LYS
B
348
−50.290
−19.101
.299
1.00
29.24
C


ATOM
13489
CG
LYS
B
348
−51.513
−19.470
−.576
1.00
30.97
C


ATOM
13492
CD
LYS
B
348
−51.051
−20.300
−1.803
1.00
33.66
C


ATOM
13495
CE
LYS
B
348
−52.033
−20.244
−2.989
1.00
34.52
C


ATOM
13498
NZ
LYS
B
348
−53.445
−20.542
−2.607
1.00
35.61
N


ATOM
13502
C
LYS
B
348
−49.330
−18.029
2.358
1.00
27.97
C


ATOM
13503
O
LYS
B
348
−48.763
−18.948
2.925
1.00
27.88
O


ATOM
13505
N
GLY
B
349
−48.874
−16.785
2.403
1.00
27.21
N


ATOM
13506
CA
GLY
B
349
−47.625
−16.473
3.075
1.00
26.87
C


ATOM
13509
C
GLY
B
349
−46.437
−17.227
2.514
1.00
26.71
C


ATOM
13510
O
GLY
B
349
−45.576
−17.669
3.271
1.00
26.65
O


ATOM
13512
N
GLU
B
350
−46.409
−17.390
1.191
1.00
26.61
N


ATOM
13513
CA
GLU
B
350
−45.263
−17.953
.470
1.00
26.43
C


ATOM
13515
CB
GLU
B
350
−45.624
−19.310
−.128
1.00
26.85
C


ATOM
13518
CG
GLU
B
350
−45.685
−20.453
.888
1.00
29.63
C


ATOM
13521
CD
GLU
B
350
−44.304
−21.036
1.227
1.00
34.21
C


ATOM
13522
OE1
GLU
B
350
−43.417
−21.045
.328
1.00
36.93
O


ATOM
13523
OE2
GLU
B
350
−44.106
−21.498
2.384
1.00
35.89
O


ATOM
13524
C
GLU
B
350
−44.900
−16.981
−.637
1.00
25.49
C


ATOM
13525
O
GLU
B
350
−45.774
−16.312
−1.181
1.00
25.35
O


ATOM
13527
N
ASN
B
351
−43.616
−16.866
−.955
1.00
24.74
N


ATOM
13528
CA
ASN
B
351
−43.206
−16.046
−2.090
1.00
24.47
C


ATOM
13530
CB
ASN
B
351
−41.851
−15.369
−1.867
1.00
24.94
C


ATOM
13533
CG
ASN
B
351
−41.428
−14.489
−3.062
1.00
26.98
C


ATOM
13534
OD1
ASN
B
351
−41.976
−14.605
−4.170
1.00
28.96
O


ATOM
13535
ND2
ASN
B
351
−40.457
−13.601
−2.834
1.00
29.55
N


ATOM
13538
C
ASN
B
351
−43.095
−16.918
−3.303
1.00
23.33
C


ATOM
13539
O
ASN
B
351
−42.120
−17.641
−3.429
1.00
23.47
O


ATOM
13541
N
ILE
B
352
−44.060
−16.823
−4.208
1.00
22.09
N


ATOM
13542
CA
ILE
B
352
−44.048
−17.644
−5.410
1.00
21.22
C


ATOM
13544
CB
ILE
B
352
−45.452
−18.213
−5.675
1.00
21.23
C


ATOM
13546
CG1
ILE
B
352
−46.464
−17.080
−5.913
1.00
21.11
C


ATOM
13549
CD1
ILE
B
352
−47.346
−17.305
−7.126
1.00
20.33
C


ATOM
13553
CG2
ILE
B
352
−45.875
−19.116
−4.519
1.00
19.79
C


ATOM
13557
C
ILE
B
352
−43.508
−16.947
−6.689
1.00
20.88
C


ATOM
13558
O
ILE
B
352
−43.486
−17.553
−7.758
1.00
20.76
O


ATOM
13560
N
LEU
B
353
−43.030
−15.705
−6.574
1.00
20.44
N


ATOM
13561
CA
LEU
B
353
−42.603
−14.907
−7.750
1.00
19.84
C


ATOM
13563
CB
LEU
B
353
−42.055
−13.527
−7.325
1.00
19.67
C


ATOM
13566
CG
LEU
B
353
−42.003
−12.339
−8.311
1.00
18.47
C


ATOM
13568
CD1
LEU
B
353
−43.306
−12.083
−9.008
1.00
17.03
C


ATOM
13572
CD2
LEU
B
353
−41.604
−11.064
−7.597
1.00
17.08
C


ATOM
13576
C
LEU
B
353
−41.587
−15.628
−8.633
1.00
19.81
C


ATOM
13577
O
LEU
B
353
−41.720
−15.596
−9.851
1.00
19.55
O


ATOM
13579
N
PRO
B
354
−40.578
−16.299
−8.024
1.00
20.01
N


ATOM
13580
CA
PRO
B
354
−39.571
−17.010
−8.822
1.00
19.73
C


ATOM
13582
CB
PRO
B
354
−38.781
−17.796
−7.779
1.00
19.55
C


ATOM
13585
CG
PRO
B
354
−38.928
−17.037
−6.542
1.00
19.61
C


ATOM
13588
CD
PRO
B
354
−40.289
−16.413
−6.578
1.00
19.90
C


ATOM
13591
C
PRO
B
354
−40.187
−17.971
−9.804
1.00
19.87
C


ATOM
13592
O
PRO
B
354
−39.693
−18.103
−10.918
1.00
20.08
O


ATOM
13593
N
TYR
B
355
−41.264
−18.636
−9.387
1.00
20.14
N


ATOM
13594
CA
TYR
B
355
−41.909
−19.665
−10.216
1.00
20.24
C


ATOM
13596
CB
TYR
B
355
−42.878
−20.520
−9.394
1.00
20.40
C


ATOM
13599
CG
TYR
B
355
−42.189
−21.153
−8.214
1.00
21.82
C


ATOM
13600
CD1
TYR
B
355
−41.119
−21.999
−8.412
1.00
22.86
C


ATOM
13602
CE1
TYR
B
355
−40.457
−22.564
−7.353
1.00
25.07
C


ATOM
13604
CZ
TYR
B
355
−40.850
−22.285
−6.053
1.00
25.58
C


ATOM
13605
OH
TYR
B
355
−40.153
−22.887
−5.020
1.00
27.33
O


ATOM
13607
CE2
TYR
B
355
−41.918
−21.433
−5.815
1.00
23.93
C


ATOM
13609
CD2
TYR
B
355
−42.577
−20.867
−6.900
1.00
23.10
C


ATOM
13611
C
TYR
B
355
−42.625
−19.001
−11.361
1.00
19.67
C


ATOM
13612
O
TYR
B
355
−42.455
−19.405
−12.510
1.00
19.75
O


ATOM
13614
N
LEU
B
356
−43.385
−17.954
−11.030
1.00
18.97
N


ATOM
13615
CA
LEU
B
356
−44.180
−17.205
−12.004
1.00
18.26
C


ATOM
13617
CB
LEU
B
356
−45.039
−16.157
−11.293
1.00
18.03
C


ATOM
13620
CG
LEU
B
356
−46.056
−16.727
−10.312
1.00
18.13
C


ATOM
13622
CD1
LEU
B
356
−46.691
−15.613
−9.500
1.00
19.37
C


ATOM
13626
CD2
LEU
B
356
−47.106
−17.521
−11.046
1.00
17.93
C


ATOM
13630
C
LEU
B
356
−43.298
−16.536
−13.056
1.00
17.76
C


ATOM
13631
O
LEU
B
356
−43.598
−16.567
−14.259
1.00
16.93
O


ATOM
13633
N
THR
B
357
−42.201
−15.949
−12.600
1.00
17.56
N


ATOM
13634
CA
THR
B
357
−41.335
−15.215
−13.501
1.00
17.63
C


ATOM
13636
CB
THR
B
357
−40.438
−14.236
−12.759
1.00
17.69
C


ATOM
13638
OG1
THR
B
357
−39.530
−14.974
−11.934
1.00
18.39
O


ATOM
13640
CG2
THR
B
357
−41.288
−13.242
−11.927
1.00
16.47
C


ATOM
13644
C
THR
B
357
−40.477
−16.145
−14.356
1.00
17.55
C


ATOM
13645
O
THR
B
357
−40.154
−15.793
−15.498
1.00
17.17
O


ATOM
13647
N
LYS
B
358
−40.127
−17.321
−13.824
1.00
17.37
N


ATOM
13648
CA
LYS
B
358
−39.462
−18.337
−14.649
1.00
17.55
C


ATOM
13650
CB
LYS
B
358
−39.030
−19.542
−13.827
1.00
17.87
C


ATOM
13653
CG
LYS
B
358
−38.450
−20.718
−14.640
1.00
18.75
C


ATOM
13656
CD
LYS
B
358
−37.013
−20.497
−15.112
1.00
20.18
C


ATOM
13659
CE
LYS
B
358
−36.361
−21.843
−15.457
1.00
21.49
C


ATOM
13662
NZ
LYS
B
358
−35.189
−21.702
−16.361
1.00
22.89
N


ATOM
13666
C
LYS
B
358
−40.403
−18.777
−15.754
1.00
17.43
C


ATOM
13667
O
LYS
B
358
−40.031
−18.775
−16.926
1.00
17.52
O


ATOM
13669
N
ALA
B
359
−41.633
−19.120
−15.384
1.00
17.42
N


ATOM
13670
CA
ALA
B
359
−42.654
−19.471
−16.359
1.00
17.52
C


ATOM
13672
CB
ALA
B
359
−44.011
−19.434
−15.738
1.00
17.16
C


ATOM
13676
C
ALA
B
359
−42.585
−18.521
−17.531
1.00
18.18
C


ATOM
13677
O
ALA
B
359
−42.513
−18.956
−18.675
1.00
18.50
O


ATOM
13679
N
TRP
B
360
−42.556
−17.223
−17.245
1.00
19.14
N


ATOM
13680
CA
TRP
B
360
−42.526
−16.206
−18.301
1.00
19.77
C


ATOM
13682
CB
TRP
B
360
−42.922
−14.837
−17.746
1.00
20.15
C


ATOM
13685
CG
TRP
B
360
−44.377
−14.653
−17.813
1.00
20.50
C


ATOM
13686
CD1
TRP
B
360
−45.259
−14.729
−16.788
1.00
22.15
C


ATOM
13688
NE1
TRP
B
360
−46.536
−14.533
−17.248
1.00
22.84
N


ATOM
13690
CE2
TRP
B
360
−46.487
−14.348
−18.603
1.00
21.68
C


ATOM
13691
CD2
TRP
B
360
−45.134
−14.418
−18.987
1.00
20.85
C


ATOM
13692
CE3
TRP
B
360
−44.802
−14.253
−20.334
1.00
21.21
C


ATOM
13694
CZ3
TRP
B
360
−45.821
−14.025
−21.245
1.00
20.75
C


ATOM
13696
CH2
TRP
B
360
−47.166
−13.961
−20.827
1.00
21.21
C


ATOM
13698
CZ2
TRP
B
360
−47.515
−14.123
−19.516
1.00
20.97
C


ATOM
13700
C
TRP
B
360
−41.215
−16.110
−19.081
1.00
19.96
C


ATOM
13701
O
TRP
B
360
−41.242
−15.791
−20.271
1.00
19.94
O


ATOM
13703
N
ALA
B
361
−40.089
−16.368
−18.420
1.00
20.14
N


ATOM
13704
CA
ALA
B
361
−38.790
−16.437
−19.102
1.00
20.41
C


ATOM
13706
CB
ALA
B
361
−37.676
−16.581
−18.102
1.00
20.67
C


ATOM
13710
C
ALA
B
361
−38.763
−17.618
−20.041
1.00
20.55
C


ATOM
13711
O
ALA
B
361
−38.330
−17.510
−21.187
1.00
20.76
O


ATOM
13713
N
ASP
B
362
−39.230
−18.749
−19.534
1.00
20.57
N


ATOM
13714
CA
ASP
B
362
−39.360
−19.965
−20.326
1.00
20.97
C


ATOM
13716
CB
ASP
B
362
−39.984
−21.082
−19.470
1.00
21.39
C


ATOM
13719
CG
ASP
B
362
−38.938
−21.902
−18.693
1.00
22.80
C


ATOM
13720
OD1
ASP
B
362
−38.836
−23.109
−18.970
1.00
28.57
O


ATOM
13721
OD2
ASP
B
362
−38.210
−21.384
−17.825
1.00
22.78
O


ATOM
13722
C
ASP
B
362
−40.179
−19.748
−21.618
1.00
20.66
C


ATOM
13723
O
ASP
B
362
−39.740
−20.141
−22.701
1.00
20.69
O


ATOM
13725
N
LEU
B
363
−41.346
−19.110
−21.501
1.00
20.22
N


ATOM
13726
CA
LEU
B
363
−42.245
−18.885
−22.648
1.00
19.82
C


ATOM
13728
CB
LEU
B
363
−43.592
−18.327
−22.164
1.00
19.11
C


ATOM
13731
CG
LEU
B
363
−44.644
−17.945
−23.209
1.00
17.02
C


ATOM
13733
CD1
LEU
B
363
−44.829
−19.033
−24.214
1.00
16.20
C


ATOM
13737
CD2
LEU
B
363
−45.979
−17.618
−22.586
1.00
14.21
C


ATOM
13741
C
LEU
B
363
−41.633
−17.950
−23.706
1.00
20.76
C


ATOM
13742
O
LEU
B
363
−41.656
−18.235
−24.910
1.00
21.00
O


ATOM
13744
N
CYS
B
364
−41.088
−16.826
−23.253
1.00
21.42
N


ATOM
13745
CA
CYS
B
364
−40.427
−15.884
−24.147
1.00
21.67
C


ATOM
13747
CB
CYS
B
364
−39.969
−14.639
−23.376
1.00
21.86
C


ATOM
13750
SG
CYS
B
364
−41.327
−13.638
−22.722
1.00
23.36
S


ATOM
13752
C
CYS
B
364
−39.229
−16.547
−24.835
1.00
21.52
C


ATOM
13753
O
CYS
B
364
−39.010
−16.323
−26.037
1.00
21.67
O


ATOM
13755
N
ASN
B
365
−38.454
−17.352
−24.095
1.00
20.83
N


ATOM
13756
CA
ASN
B
365
−37.306
−18.025
−24.713
1.00
20.65
C


ATOM
13758
CB
ASN
B
365
−36.425
−18.756
−23.691
1.00
20.74
C


ATOM
13761
CG
ASN
B
365
−35.330
−17.865
−23.100
1.00
20.53
C


ATOM
13762
OD1
ASN
B
365
−34.553
−17.229
−23.830
1.00
18.26
O


ATOM
13763
ND2
ASN
B
365
−35.252
−17.841
−21.763
1.00
20.69
N


ATOM
13766
C
ASN
B
365
−37.756
−18.987
−25.811
1.00
20.43
C


ATOM
13767
O
ASN
B
365
−36.998
−19.253
−26.759
1.00
20.11
O


ATOM
13769
N
ALA
B
366
−38.987
−19.492
−25.667
1.00
20.01
N


ATOM
13770
CA
ALA
B
366
−39.618
−20.340
−26.665
1.00
19.70
C


ATOM
13772
CB
ALA
B
366
−40.766
−21.113
−26.045
1.00
19.53
C


ATOM
13776
C
ALA
B
366
−40.099
−19.494
−27.838
1.00
19.74
C


ATOM
13777
O
ALA
B
366
−39.846
−19.824
−28.989
1.00
19.61
O


ATOM
13779
N
PHE
B
367
−40.791
−18.399
−27.553
1.00
19.99
N


ATOM
13780
CA
PHE
B
367
−41.138
−17.446
−28.606
1.00
20.36
C


ATOM
13782
CB
PHE
B
367
−41.805
−16.194
−28.026
1.00
20.62
C


ATOM
13785
CG
PHE
B
367
−43.200
−16.403
−27.537
1.00
21.75
C


ATOM
13786
CD1
PHE
B
367
−44.136
−17.071
−28.315
1.00
23.00
C


ATOM
13788
CE1
PHE
B
367
−45.435
−17.242
−27.874
1.00
23.60
C


ATOM
13790
CZ
PHE
B
367
−45.819
−16.731
−26.648
1.00
23.64
C


ATOM
13792
CE2
PHE
B
367
−44.901
−16.049
−25.871
1.00
23.56
C


ATOM
13794
CD2
PHE
B
367
−43.599
−15.883
−26.316
1.00
22.91
C


ATOM
13796
C
PHE
B
367
−39.906
−16.986
−29.393
1.00
20.19
C


ATOM
13797
O
PHE
B
367
−39.934
−16.903
−30.615
1.00
19.98
O


ATOM
13799
N
LEU
B
368
−38.839
−16.659
−28.675
1.00
20.24
N


ATOM
13800
CA
LEU
B
368
−37.629
−16.161
−29.298
1.00
20.31
C


ATOM
13802
CB
LEU
B
368
−36.569
−15.900
−28.232
1.00
20.27
C


ATOM
13805
CG
LEU
B
368
−35.235
−15.313
−28.694
1.00
20.12
C


ATOM
13807
CD1
LEU
B
368
−35.417
−14.069
−29.592
1.00
20.05
C


ATOM
13811
CD2
LEU
B
368
−34.409
−14.987
−27.465
1.00
18.60
C


ATOM
13815
C
LEU
B
368
−37.122
−17.179
−30.295
1.00
20.53
C


ATOM
13816
O
LEU
B
368
−36.844
−16.844
−31.446
1.00
20.49
O


ATOM
13818
N
GLN
B
369
−37.032
−18.426
−29.832
1.00
20.80
N


ATOM
13819
CA
GLN
B
369
−36.565
−19.557
−30.638
1.00
20.90
C


ATOM
13821
CB
GLN
B
369
−36.614
−20.857
−29.815
1.00
20.98
C


ATOM
13824
CG
GLN
B
369
−36.343
−22.159
−30.576
1.00
20.75
C


ATOM
13827
CD
GLN
B
369
−34.946
−22.238
−31.126
1.00
20.29
C


ATOM
13828
OE1
GLN
B
369
−34.718
−21.984
−32.305
1.00
20.17
O


ATOM
13829
NE2
GLN
B
369
−33.996
−22.581
−30.272
1.00
20.33
N


ATOM
13832
C
GLN
B
369
−37.365
−19.718
−31.910
1.00
21.04
C


ATOM
13833
O
GLN
B
369
−36.803
−20.097
−32.929
1.00
20.82
O


ATOM
13835
N
GLU
B
370
−38.668
−19.453
−31.863
1.00
21.80
N


ATOM
13836
CA
GLU
B
370
−39.480
−19.512
−33.087
1.00
22.73
C


ATOM
13838
CB
GLU
B
370
−40.996
−19.518
−32.801
1.00
23.18
C


ATOM
13841
CG
GLU
B
370
−41.449
−20.608
−31.809
1.00
25.92
C


ATOM
13844
CD
GLU
B
370
−42.927
−21.064
−31.957
1.00
29.74
C


ATOM
13845
OE1
GLU
B
370
−43.840
−20.191
−32.101
1.00
30.13
O


ATOM
13846
OE2
GLU
B
370
−43.156
−22.316
−31.892
1.00
31.94
O


ATOM
13847
C
GLU
B
370
−39.079
−18.358
−34.016
1.00
22.62
C


ATOM
13848
O
GLU
B
370
−38.933
−18.565
−35.221
1.00
22.53
O


ATOM
13850
N
ALA
B
371
−38.864
−17.166
−33.456
1.00
22.65
N


ATOM
13851
CA
ALA
B
371
−38.427
−16.023
−34.254
1.00
22.95
C


ATOM
13853
CB
ALA
B
371
−38.375
−14.753
−33.424
1.00
22.97
C


ATOM
13857
C
ALA
B
371
−37.070
−16.296
−34.891
1.00
23.13
C


ATOM
13858
O
ALA
B
371
−36.900
−16.063
−36.091
1.00
23.38
O


ATOM
13860
N
LYS
B
372
−36.113
−16.804
−34.107
1.00
23.15
N


ATOM
13861
CA
LYS
B
372
−34.776
−17.102
−34.640
1.00
23.10
C


ATOM
13863
CB
LYS
B
372
−33.808
−17.633
−33.575
1.00
22.85
C


ATOM
13866
CG
LYS
B
372
−33.414
−16.616
−32.514
1.00
24.28
C


ATOM
13869
CD
LYS
B
372
−31.973
−16.806
−31.969
1.00
26.34
C


ATOM
13872
CE
LYS
B
372
−31.919
−17.407
−30.544
1.00
27.84
C


ATOM
13875
NZ
LYS
B
372
−31.673
−16.405
−29.458
1.00
27.93
N


ATOM
13879
C
LYS
B
372
−34.887
−18.093
−35.790
1.00
23.16
C


ATOM
13880
O
LYS
B
372
−34.231
−17.920
−36.804
1.00
23.73
O


ATOM
13882
N
TRP
B
373
−35.720
−19.122
−35.658
1.00
23.11
N


ATOM
13883
CA
TRP
B
373
−35.844
−20.094
−36.742
1.00
22.99
C


ATOM
13885
CB
TRP
B
373
−36.746
−21.274
−36.370
1.00
22.71
C


ATOM
13888
CG
TRP
B
373
−36.081
−22.343
−35.562
1.00
20.71
C


ATOM
13889
CD1
TRP
B
373
−34.770
−22.740
−35.623
1.00
19.89
C


ATOM
13891
NE1
TRP
B
373
−34.540
−23.757
−34.734
1.00
19.05
N


ATOM
13893
CE2
TRP
B
373
−35.715
−24.050
−34.090
1.00
18.91
C


ATOM
13894
CD2
TRP
B
373
−36.707
−23.184
−34.599
1.00
18.41
C


ATOM
13895
CE3
TRP
B
373
−38.007
−23.288
−34.105
1.00
15.66
C


ATOM
13897
CZ3
TRP
B
373
−38.271
−24.216
−33.130
1.00
15.41
C


ATOM
13899
CH2
TRP
B
373
−37.276
−25.069
−32.647
1.00
16.33
C


ATOM
13901
CZ2
TRP
B
373
−35.994
−25.005
−33.112
1.00
17.53
C


ATOM
13903
C
TRP
B
373
−36.374
−19.416
−37.991
1.00
23.59
C


ATOM
13904
O
TRP
B
373
−35.878
−19.653
−39.096
1.00
23.60
O


ATOM
13906
N
LEU
B
374
−37.374
−18.559
−37.801
1.00
24.32
N


ATOM
13907
CA
LEU
B
374
−38.008
−17.859
−38.915
1.00
24.66
C


ATOM
13909
CB
LEU
B
374
−39.181
−17.019
−38.428
1.00
24.85
C


ATOM
13912
CG
LEU
B
374
−40.112
−16.449
−39.496
1.00
25.45
C


ATOM
13914
CD1
LEU
B
374
−41.002
−17.535
−40.070
1.00
24.83
C


ATOM
13918
CD2
LEU
B
374
−40.959
−15.293
−38.885
1.00
26.92
C


ATOM
13922
C
LEU
B
374
−37.009
−16.975
−39.618
1.00
24.64
C


ATOM
13923
O
LEU
B
374
−36.934
−16.992
−40.830
1.00
24.33
O


ATOM
13925
N
TYR
B
375
−36.232
−16.220
−38.850
1.00
25.09
N


ATOM
13926
CA
TYR
B
375
−35.283
−15.274
−39.433
1.00
25.71
C


ATOM
13928
CB
TYR
B
375
−34.534
−14.479
−38.349
1.00
25.91
C


ATOM
13931
CG
TYR
B
375
−33.536
−13.468
−38.892
1.00
27.11
C


ATOM
13932
CD1
TYR
B
375
−33.950
−12.200
−39.305
1.00
27.98
C


ATOM
13934
CE1
TYR
B
375
−33.039
−11.271
−39.811
1.00
28.61
C


ATOM
13936
CZ
TYR
B
375
−31.693
−11.605
−39.904
1.00
29.13
C


ATOM
13937
OH
TYR
B
375
−30.790
−10.685
−40.397
1.00
29.83
O


ATOM
13939
CE2
TYR
B
375
−31.256
−12.863
−39.501
1.00
28.79
C


ATOM
13941
CD2
TYR
B
375
−32.177
−13.783
−38.995
1.00
28.03
C


ATOM
13943
C
TYR
B
375
−34.305
−16.036
−40.301
1.00
25.64
C


ATOM
13944
O
TYR
B
375
−34.201
−15.788
−41.503
1.00
25.74
O


ATOM
13946
N
ASN
B
376
−33.635
−17.000
−39.685
1.00
25.73
N


ATOM
13947
CA
ASN
B
376
−32.599
−17.777
−40.346
1.00
25.78
C


ATOM
13949
CB
ASN
B
376
−31.739
−18.497
−39.303
1.00
25.73
C


ATOM
13952
CG
ASN
B
376
−31.155
−17.565
−38.273
1.00
25.13
C


ATOM
13953
OD1
ASN
B
376
−30.491
−16.590
−38.601
1.00
25.53
O


ATOM
13954
ND2
ASN
B
376
−31.389
−17.874
−37.013
1.00
24.64
N


ATOM
13957
C
ASN
B
376
−33.126
−18.824
−41.332
1.00
26.04
C


ATOM
13958
O
ASN
B
376
−32.343
−19.644
−41.807
1.00
26.36
O


ATOM
13960
N
LYS
B
377
−34.428
−18.824
−41.632
1.00
26.16
N


ATOM
13961
CA
LYS
B
377
−35.012
−19.811
−42.552
1.00
26.27
C


ATOM
13963
CB
LYS
B
377
−34.575
−19.538
−44.010
1.00
26.51
C


ATOM
13966
CG
LYS
B
377
−35.470
−18.561
−44.802
1.00
28.01
C


ATOM
13969
CD
LYS
B
377
−34.629
−17.592
−45.667
1.00
29.99
C


ATOM
13972
CE
LYS
B
377
−35.493
−16.605
−46.465
1.00
31.02
C


ATOM
13975
NZ
LYS
B
377
−36.420
−15.819
−45.589
1.00
32.17
N


ATOM
13979
C
LYS
B
377
−34.647
−21.243
−42.150
1.00
25.93
C


ATOM
13980
O
LYS
B
377
−34.380
−22.084
−43.003
1.00
25.82
O


ATOM
13982
N
SER
B
378
−34.637
−21.522
−40.852
1.00
25.65
N


ATOM
13983
CA
SER
B
378
−34.324
−22.860
−40.385
1.00
25.54
C


ATOM
13985
CB
SER
B
378
−34.132
−22.877
−38.882
1.00
25.41
C


ATOM
13988
OG
SER
B
378
−32.905
−22.269
−38.570
1.00
25.67
O


ATOM
13990
C
SER
B
378
−35.412
−23.838
−40.790
1.00
25.62
C


ATOM
13991
O
SER
B
378
−36.495
−23.435
−41.199
1.00
25.70
O


ATOM
13993
N
THR
B
379
−35.108
−25.129
−40.690
1.00
25.66
N


ATOM
13994
CA
THR
B
379
−36.038
−26.175
−41.097
1.00
25.55
C


ATOM
13996
CB
THR
B
379
−35.788
−26.635
−42.546
1.00
25.59
C


ATOM
13998
OG1
THR
B
379
−34.391
−26.899
−42.736
1.00
25.46
O


ATOM
14000
CG2
THR
B
379
−36.255
−25.574
−43.528
1.00
25.88
C


ATOM
14004
C
THR
B
379
−35.886
−27.348
−40.160
1.00
25.45
C


ATOM
14005
O
THR
B
379
−35.372
−28.393
−40.548
1.00
25.70
O


ATOM
14007
N
PRO
B
380
−36.335
−27.179
−38.915
1.00
25.37
N


ATOM
14008
CA
PRO
B
380
−36.144
−28.182
−37.876
1.00
25.22
C


ATOM
14010
CB
PRO
B
380
−36.500
−27.437
−36.583
1.00
25.19
C


ATOM
14013
CG
PRO
B
380
−36.643
−26.021
−36.955
1.00
25.83
C


ATOM
14016
CD
PRO
B
380
−37.025
−25.998
−38.390
1.00
25.71
C


ATOM
14019
C
PRO
B
380
−37.052
−29.379
−38.009
1.00
24.82
C


ATOM
14020
O
PRO
B
380
−38.143
−29.280
−38.575
1.00
24.84
O


ATOM
14021
N
THR
B
381
−36.607
−30.493
−37.436
1.00
24.42
N


ATOM
14022
CA
THR
B
381
−37.386
−31.712
−37.429
1.00
23.99
C


ATOM
14024
CB
THR
B
381
−36.614
−32.873
−36.789
1.00
23.99
C


ATOM
14026
OG1
THR
B
381
−36.339
−32.575
−35.418
1.00
24.02
O


ATOM
14028
CG2
THR
B
381
−35.302
−33.117
−37.524
1.00
23.76
C


ATOM
14032
C
THR
B
381
−38.649
−31.461
−36.636
1.00
23.78
C


ATOM
14033
O
THR
B
381
−38.700
−30.548
−35.813
1.00
23.89
O


ATOM
14035
N
PHE
B
382
−39.672
−32.267
−36.889
1.00
23.53
N


ATOM
14036
CA
PHE
B
382
−40.905
−32.204
−36.105
1.00
22.97
C


ATOM
14038
CB
PHE
B
382
−41.870
−33.305
−36.527
1.00
22.89
C


ATOM
14041
CG
PHE
B
382
−43.079
−33.394
−35.655
1.00
22.26
C


ATOM
14042
CD1
PHE
B
382
−44.189
−32.601
−35.910
1.00
21.65
C


ATOM
14044
CE1
PHE
B
382
−45.300
−32.672
−35.099
1.00
20.87
C


ATOM
14046
CZ
PHE
B
382
−45.310
−33.534
−34.016
1.00
20.36
C


ATOM
14048
CE2
PHE
B
382
−44.204
−34.317
−33.744
1.00
20.52
C


ATOM
14050
CD2
PHE
B
382
−43.098
−34.243
−34.556
1.00
21.17
C


ATOM
14052
C
PHE
B
382
−40.677
−32.329
−34.605
1.00
22.69
C


ATOM
14053
O
PHE
B
382
−41.341
−31.657
−33.834
1.00
22.44
O


ATOM
14055
N
ASP
B
383
−39.764
−33.205
−34.191
1.00
22.52
N


ATOM
14056
CA
ASP
B
383
−39.491
−33.375
−32.765
1.00
22.50
C


ATOM
14058
CB
ASP
B
383
−38.531
−34.525
−32.527
1.00
22.43
C


ATOM
14061
CG
ASP
B
383
−39.174
−35.863
−32.711
1.00
22.71
C


ATOM
14062
OD1
ASP
B
383
−40.359
−35.945
−33.074
1.00
22.89
O


ATOM
14063
OD2
ASP
B
383
−38.470
−36.856
−32.492
1.00
25.17
O


ATOM
14064
C
ASP
B
383
−38.954
−32.116
−32.091
1.00
22.43
C


ATOM
14065
O
ASP
B
383
−39.438
−31.758
−31.014
1.00
22.40
O


ATOM
14067
N
ASP
B
384
−37.966
−31.464
−32.713
1.00
22.37
N


ATOM
14068
CA
ASP
B
384
−37.422
−30.191
−32.213
1.00
22.61
C


ATOM
14070
CB
ASP
B
384
−36.317
−29.648
−33.124
1.00
22.82
C


ATOM
14073
CG
ASP
B
384
−34.963
−30.208
−32.807
1.00
23.40
C


ATOM
14074
OD1
ASP
B
384
−34.847
−30.973
−31.832
1.00
25.33
O


ATOM
14075
OD2
ASP
B
384
−34.009
−29.891
−33.545
1.00
24.26
O


ATOM
14076
C
ASP
B
384
−38.482
−29.113
−32.130
1.00
22.56
C


ATOM
14077
O
ASP
B
384
−38.598
−28.429
−31.108
1.00
22.48
O


ATOM
14079
N
TYR
B
385
−39.227
−28.963
−33.227
1.00
22.36
N


ATOM
14080
CA
TYR
B
385
−40.170
−27.870
−33.402
1.00
22.18
C


ATOM
14082
CB
TYR
B
385
−40.738
−27.867
−34.812
1.00
22.05
C


ATOM
14085
CG
TYR
B
385
−41.818
−26.834
−35.019
1.00
22.60
C


ATOM
14086
CD1
TYR
B
385
−41.493
−25.553
−35.437
1.00
23.64
C


ATOM
14088
CE1
TYR
B
385
−42.462
−24.580
−35.630
1.00
25.00
C


ATOM
14090
CZ
TYR
B
385
−43.788
−24.882
−35.410
1.00
26.86
C


ATOM
14091
OH
TYR
B
385
−44.734
−23.883
−35.622
1.00
28.48
O


ATOM
14093
CE2
TYR
B
385
−44.149
−26.171
−34.980
1.00
25.95
C


ATOM
14095
CD2
TYR
B
385
−43.158
−27.133
−34.790
1.00
23.94
C


ATOM
14097
C
TYR
B
385
−41.319
−27.986
−32.446
1.00
22.13
C


ATOM
14098
O
TYR
B
385
−41.703
−27.017
−31.808
1.00
22.95
O


ATOM
14100
N
PHE
B
386
−41.899
−29.169
−32.380
1.00
21.80
N


ATOM
14101
CA
PHE
B
386
−43.048
−29.394
−31.525
1.00
21.62
C


ATOM
14103
CB
PHE
B
386
−43.624
−30.795
−31.768
1.00
21.73
C


ATOM
14106
CG
PHE
B
386
−44.834
−31.104
−30.952
1.00
21.27
C


ATOM
14107
CD1
PHE
B
386
−46.034
−30.447
−31.196
1.00
22.55
C


ATOM
14109
CE1
PHE
B
386
−47.164
−30.732
−30.448
1.00
23.14
C


ATOM
14111
CZ
PHE
B
386
−47.095
−31.699
−29.446
1.00
23.20
C


ATOM
14113
CE2
PHE
B
386
−45.896
−32.358
−29.208
1.00
21.57
C


ATOM
14115
CD2
PHE
B
386
−44.781
−32.057
−29.959
1.00
20.29
C


ATOM
14117
C
PHE
B
386
−42.630
−29.226
−30.073
1.00
21.34
C


ATOM
14118
O
PHE
B
386
−43.353
−28.639
−29.284
1.00
21.44
O


ATOM
14120
N
GLY
B
387
−41.447
−29.725
−29.736
1.00
20.84
N


ATOM
14121
CA
GLY
B
387
−40.935
−29.618
−28.387
1.00
20.57
C


ATOM
14124
C
GLY
B
387
−40.854
−28.186
−27.916
1.00
20.26
C


ATOM
14125
O
GLY
B
387
−40.930
−27.908
−26.724
1.00
20.86
O


ATOM
14127
N
ASN
B
388
−40.691
−27.268
−28.852
1.00
19.81
N


ATOM
14128
CA
ASN
B
388
−40.758
−25.853
−28.536
1.00
19.51
C


ATOM
14130
CB
ASN
B
388
−39.877
−25.086
−29.508
1.00
19.42
C


ATOM
14133
CG
ASN
B
388
−39.593
−23.700
−29.045
1.00
19.26
C


ATOM
14134
OD1
ASN
B
388
−38.916
−23.513
−28.038
1.00
18.93
O


ATOM
14135
ND2
ASN
B
388
−40.105
−22.709
−29.774
1.00
17.99
N


ATOM
14138
C
ASN
B
388
−42.200
−25.320
−28.604
1.00
19.41
C


ATOM
14139
O
ASN
B
388
−42.591
−24.447
−27.833
1.00
19.58
O


ATOM
14141
N
ALA
B
389
−42.989
−25.848
−29.532
1.00
19.11
N


ATOM
14142
CA
ALA
B
389
−44.313
−25.307
−29.808
1.00
18.87
C


ATOM
14144
CB
ALA
B
389
−44.897
−25.949
−31.060
1.00
18.87
C


ATOM
14148
C
ALA
B
389
−45.264
−25.460
−28.634
1.00
18.51
C


ATOM
14149
O
ALA
B
389
−45.916
−24.511
−28.262
1.00
18.33
O


ATOM
14151
N
TRP
B
390
−45.344
−26.652
−28.054
1.00
18.73
N


ATOM
14152
CA
TRP
B
390
−46.258
−26.887
−26.935
1.00
18.74
C


ATOM
14154
CB
TRP
B
390
−46.389
−28.377
−26.569
1.00
18.75
C


ATOM
14157
CG
TRP
B
390
−45.166
−29.122
−26.019
1.00
18.46
C


ATOM
14158
CD1
TRP
B
390
−44.390
−30.001
−26.705
1.00
18.75
C


ATOM
14160
NE1
TRP
B
390
−43.417
−30.519
−25.897
1.00
17.56
N


ATOM
14162
CE2
TRP
B
390
−43.559
−30.005
−24.642
1.00
16.67
C


ATOM
14163
CD2
TRP
B
390
−44.661
−29.124
−24.674
1.00
17.50
C


ATOM
14164
CE3
TRP
B
390
−45.008
−28.448
−23.505
1.00
18.38
C


ATOM
14166
CZ3
TRP
B
390
−44.251
−28.685
−22.347
1.00
18.34
C


ATOM
14168
CH2
TRP
B
390
−43.164
−29.573
−22.361
1.00
16.75
C


ATOM
14170
CZ2
TRP
B
390
−42.805
−30.234
−23.495
1.00
15.75
C


ATOM
14172
C
TRP
B
390
−45.861
−26.066
−25.727
1.00
18.91
C


ATOM
14173
O
TRP
B
390
−46.707
−25.691
−24.919
1.00
19.02
O


ATOM
14175
N
LYS
B
391
−44.570
−25.787
−25.612
1.00
18.95
N


ATOM
14176
CA
LYS
B
391
−44.085
−24.810
−24.643
1.00
18.85
C


ATOM
14178
CB
LYS
B
391
−42.544
−24.888
−24.508
1.00
19.52
C


ATOM
14181
CG
LYS
B
391
−42.023
−25.373
−23.143
1.00
21.17
C


ATOM
14184
CD
LYS
B
391
−40.516
−25.689
−23.191
1.00
22.87
C


ATOM
14187
CE
LYS
B
391
−40.251
−27.159
−23.508
1.00
23.91
C


ATOM
14190
NZ
LYS
B
391
−38.938
−27.354
−24.191
1.00
25.44
N


ATOM
14194
C
LYS
B
391
−44.537
−23.400
−25.032
1.00
17.57
C


ATOM
14195
O
LYS
B
391
−44.937
−22.629
−24.180
1.00
17.66
O


ATOM
14197
N
SER
B
392
−44.490
−23.068
−26.314
1.00
16.65
N


ATOM
14198
CA
SER
B
392
−44.879
−21.718
−26.764
1.00
16.27
C


ATOM
14200
CB
SER
B
392
−44.241
−21.375
−28.119
1.00
16.22
C


ATOM
14203
OG
SER
B
392
−44.937
−21.969
−29.207
1.00
15.94
O


ATOM
14205
C
SER
B
392
−46.384
−21.504
−26.866
1.00
15.87
C


ATOM
14206
O
SER
B
392
−46.825
−20.395
−27.093
1.00
15.56
O


ATOM
14208
N
SER
B
393
−47.167
−22.568
−26.724
1.00
15.92
N


ATOM
14209
CA
SER
B
393
−48.629
−22.474
−26.718
1.00
15.80
C


ATOM
14211
CB
SER
B
393
−49.240
−23.867
−26.630
1.00
15.78
C


ATOM
14214
OG
SER
B
393
−49.025
−24.426
−25.348
1.00
15.00
O


ATOM
14216
C
SER
B
393
−49.097
−21.646
−25.533
1.00
15.94
C


ATOM
14217
O
SER
B
393
−50.115
−20.948
−25.599
1.00
15.60
O


ATOM
14219
N
SER
B
394
−48.296
−21.740
−24.471
1.00
16.14
N


ATOM
14220
CA
SER
B
394
−48.487
−21.091
−23.177
1.00
16.31
C


ATOM
14222
CB
SER
B
394
−49.062
−19.662
−23.271
1.00
16.18
C


ATOM
14225
OG
SER
B
394
−50.472
−19.649
−23.358
1.00
16.57
O


ATOM
14227
C
SER
B
394
−49.316
−22.006
−22.297
1.00
16.34
C


ATOM
14228
O
SER
B
394
−49.822
−21.595
−21.261
1.00
16.47
O


ATOM
14230
N
GLY
B
395
−49.403
−23.268
−22.702
1.00
16.55
N


ATOM
14231
CA
GLY
B
395
−50.103
−24.282
−21.927
1.00
16.79
C


ATOM
14234
C
GLY
B
395
−49.543
−24.391
−20.534
1.00
16.80
C


ATOM
14235
O
GLY
B
395
−50.222
−24.083
−19.556
1.00
16.74
O


ATOM
14237
N
PRO
B
396
−48.291
−24.824
−20.430
1.00
17.07
N


ATOM
14238
CA
PRO
B
396
−47.698
−24.930
−19.103
1.00
17.18
C


ATOM
14240
CB
PRO
B
396
−46.273
−25.399
−19.386
1.00
17.09
C


ATOM
14243
CG
PRO
B
396
−46.087
−25.237
−20.874
1.00
17.77
C


ATOM
14246
CD
PRO
B
396
−47.424
−25.390
−21.470
1.00
17.20
C


ATOM
14249
C
PRO
B
396
−47.707
−23.615
−18.313
1.00
17.17
C


ATOM
14250
O
PRO
B
396
−47.921
−23.644
−17.089
1.00
17.10
O


ATOM
14251
N
LEU
B
397
−47.499
−22.475
−18.983
1.00
17.04
N


ATOM
14252
CA
LEU
B
397
−47.513
−21.183
−18.261
1.00
16.77
C


ATOM
14254
CB
LEU
B
397
−47.116
−19.969
−19.135
1.00
16.84
C


ATOM
14257
CG
LEU
B
397
−47.145
−18.576
−18.458
1.00
16.91
C


ATOM
14259
CD1
LEU
B
397
−46.577
−18.641
−17.096
1.00
18.36
C


ATOM
14263
CD2
LEU
B
397
−46.373
−17.515
−19.196
1.00
16.88
C


ATOM
14267
C
LEU
B
397
−48.894
−20.988
−17.682
1.00
16.24
C


ATOM
14268
O
LEU
B
397
−49.051
−20.710
−16.494
1.00
16.09
O


ATOM
14270
N
GLN
B
398
−49.902
−21.173
−18.515
1.00
15.72
N


ATOM
14271
CA
GLN
B
398
−51.262
−21.093
−18.024
1.00
15.49
C


ATOM
14273
CB
GLN
B
398
−52.267
−21.387
−19.120
1.00
15.51
C


ATOM
14276
CG
GLN
B
398
−52.371
−20.275
−20.118
1.00
16.12
C


ATOM
14279
CD
GLN
B
398
−53.436
−20.545
−21.114
1.00
17.86
C


ATOM
14280
OE1
GLN
B
398
−54.509
−21.028
−20.757
1.00
20.99
O


ATOM
14281
NE2
GLN
B
398
−53.170
−20.239
−22.374
1.00
18.31
N


ATOM
14284
C
GLN
B
398
−51.471
−22.040
−16.873
1.00
15.03
C


ATOM
14285
O
GLN
B
398
−51.974
−21.638
−15.843
1.00
15.21
O


ATOM
14287
N
LEU
B
399
−51.065
−23.291
−17.022
1.00
14.72
N


ATOM
14288
CA
LEU
B
399
−51.361
−24.254
−15.978
1.00
14.65
C


ATOM
14290
CB
LEU
B
399
−51.201
−25.688
−16.475
1.00
14.44
C


ATOM
14293
CG
LEU
B
399
−52.250
−26.191
−17.478
1.00
14.28
C


ATOM
14295
CD1
LEU
B
399
−51.907
−27.633
−17.846
1.00
15.50
C


ATOM
14299
CD2
LEU
B
399
−53.713
−26.077
−16.986
1.00
10.96
C


ATOM
14303
C
LEU
B
399
−50.554
−23.995
−14.704
1.00
14.88
C


ATOM
14304
O
LEU
B
399
−51.100
−24.161
−13.618
1.00
15.21
O


ATOM
14306
N
ILE
B
400
−49.291
−23.562
−14.810
1.00
14.91
N


ATOM
14307
CA
ILE
B
400
−48.532
−23.174
−13.607
1.00
14.89
C


ATOM
14309
CB
ILE
B
400
−47.158
−22.574
−13.907
1.00
15.19
C


ATOM
14311
CG1
ILE
B
400
−46.189
−23.674
−14.353
1.00
16.76
C


ATOM
14314
CD1
ILE
B
400
−44.777
−23.162
−14.716
1.00
18.19
C


ATOM
14318
CG2
ILE
B
400
−46.603
−21.906
−12.665
1.00
13.65
C


ATOM
14322
C
ILE
B
400
−49.288
−22.137
−12.819
1.00
14.77
C


ATOM
14323
O
ILE
B
400
−49.485
−22.302
−11.632
1.00
15.36
O


ATOM
14325
N
PHE
B
401
−49.717
−21.071
−13.486
1.00
14.59
N


ATOM
14326
CA
PHE
B
401
−50.491
−20.001
−12.844
1.00
14.22
C


ATOM
14328
CB
PHE
B
401
−50.825
−18.900
−13.845
1.00
14.12
C


ATOM
14331
CG
PHE
B
401
−49.803
−17.790
−13.872
1.00
13.83
C


ATOM
14332
CD1
PHE
B
401
−50.012
−16.623
−13.173
1.00
12.77
C


ATOM
14334
CE1
PHE
B
401
−49.074
−15.629
−13.189
1.00
13.09
C


ATOM
14336
CZ
PHE
B
401
−47.906
−15.781
−13.902
1.00
12.96
C


ATOM
14338
CE2
PHE
B
401
−47.684
−16.928
−14.592
1.00
12.86
C


ATOM
14340
CD2
PHE
B
401
−48.622
−17.932
−14.574
1.00
13.30
C


ATOM
14342
C
PHE
B
401
−51.765
−20.478
−12.212
1.00
14.26
C


ATOM
14343
O
PHE
B
401
−52.184
−19.944
−11.207
1.00
13.90
O


ATOM
14345
N
ALA
B
402
−52.377
−21.480
−12.828
1.00
15.09
N


ATOM
14346
CA
ALA
B
402
−53.641
−22.054
−12.364
1.00
15.76
C


ATOM
14348
CB
ALA
B
402
−54.264
−22.899
−13.454
1.00
15.57
C


ATOM
14352
C
ALA
B
402
−53.417
−22.896
−11.129
1.00
16.63
C


ATOM
14353
O
ALA
B
402
−54.284
−22.970
−10.259
1.00
17.00
O


ATOM
14355
N
TYR
B
403
−52.253
−23.544
−11.060
1.00
17.50
N


ATOM
14356
CA
TYR
B
403
−51.885
−24.317
−9.894
1.00
17.86
C


ATOM
14358
CB
TYR
B
403
−50.486
−24.911
−10.038
1.00
17.73
C


ATOM
14361
CG
TYR
B
403
−50.006
−25.576
−8.764
1.00
18.24
C


ATOM
14362
CD1
TYR
B
403
−50.401
−26.867
−8.436
1.00
18.12
C


ATOM
14364
CE1
TYR
B
403
−49.971
−27.476
−7.273
1.00
18.07
C


ATOM
14366
CZ
TYR
B
403
−49.145
−26.790
−6.409
1.00
18.62
C


ATOM
14367
OH
TYR
B
403
−48.727
−27.383
−5.244
1.00
17.70
O


ATOM
14369
CE2
TYR
B
403
−48.748
−25.499
−6.703
1.00
18.93
C


ATOM
14371
CD2
TYR
B
403
−49.177
−24.901
−7.876
1.00
18.88
C


ATOM
14373
C
TYR
B
403
−51.966
−23.461
−8.630
1.00
18.48
C


ATOM
14374
O
TYR
B
403
−52.494
−23.908
−7.616
1.00
18.66
O


ATOM
14376
N
PHE
B
404
−51.468
−22.232
−8.682
1.00
18.91
N


ATOM
14377
CA
PHE
B
404
−51.400
−21.430
−7.468
1.00
19.53
C


ATOM
14379
CB
PHE
B
404
−50.395
−20.325
−7.644
1.00
19.35
C


ATOM
14382
CG
PHE
B
404
−49.014
−20.808
−7.799
1.00
18.79
C


ATOM
14383
CD1
PHE
B
404
−48.311
−21.246
−6.701
1.00
17.67
C


ATOM
14385
CE1
PHE
B
404
−47.001
−21.683
−6.832
1.00
18.44
C


ATOM
14387
CZ
PHE
B
404
−46.384
−21.688
−8.078
1.00
18.44
C


ATOM
14389
CE2
PHE
B
404
−47.083
−21.245
−9.190
1.00
18.79
C


ATOM
14391
CD2
PHE
B
404
−48.396
−20.805
−9.047
1.00
18.90
C


ATOM
14393
C
PHE
B
404
−52.733
−20.817
−7.072
1.00
20.49
C


ATOM
14394
O
PHE
B
404
−52.925
−20.389
−5.924
1.00
19.95
O


ATOM
14396
N
ALA
B
405
−53.636
−20.756
−8.043
1.00
21.92
N


ATOM
14397
CA
ALA
B
405
−54.918
−20.106
−7.872
1.00
23.09
C


ATOM
14399
CB
ALA
B
405
−55.333
−19.426
−9.167
1.00
23.15
C


ATOM
14403
C
ALA
B
405
−55.959
−21.113
−7.446
1.00
24.23
C


ATOM
14404
O
ALA
B
405
−57.003
−20.726
−6.925
1.00
24.33
O


ATOM
14406
N
VAL
B
406
−55.657
−22.399
−7.662
1.00
25.80
N


ATOM
14407
CA
VAL
B
406
−56.569
−23.511
−7.355
1.00
26.88
C


ATOM
14409
CB
VAL
B
406
−56.640
−24.514
−8.512
1.00
26.64
C


ATOM
14411
CG1
VAL
B
406
−57.132
−25.854
−8.012
1.00
27.24
C


ATOM
14415
CG2
VAL
B
406
−57.547
−23.986
−9.593
1.00
26.45
C


ATOM
14419
C
VAL
B
406
−56.161
−24.266
−6.094
1.00
27.91
C


ATOM
14420
O
VAL
B
406
−56.932
−24.345
−5.155
1.00
28.28
O


ATOM
14422
N
VAL
B
407
−54.954
−24.825
−6.087
1.00
29.25
N


ATOM
14423
CA
VAL
B
407
−54.443
−25.573
−4.941
1.00
30.16
C


ATOM
14425
CB
VAL
B
407
−53.128
−26.276
−5.279
1.00
30.04
C


ATOM
14427
CG1
VAL
B
407
−52.482
−26.831
−4.032
1.00
30.42
C


ATOM
14431
CG2
VAL
B
407
−53.378
−27.376
−6.280
1.00
30.14
C


ATOM
14435
C
VAL
B
407
−54.208
−24.646
−3.755
1.00
31.34
C


ATOM
14436
O
VAL
B
407
−53.535
−23.618
−3.876
1.00
31.46
O


ATOM
14438
N
GLN
B
408
−54.753
−25.032
−2.604
1.00
32.63
N


ATOM
14439
CA
GLN
B
408
−54.727
−24.191
−1.417
1.00
33.51
C


ATOM
14441
CB
GLN
B
408
−55.891
−24.572
−.514
1.00
33.84
C


ATOM
14444
CG
GLN
B
408
−56.161
−23.548
.577
1.00
35.49
C


ATOM
14447
CD
GLN
B
408
−57.623
−23.161
.656
1.00
37.61
C


ATOM
14448
OE1
GLN
B
408
−58.519
−24.006
.501
1.00
38.23
O


ATOM
14449
NE2
GLN
B
408
−57.876
−21.874
.893
1.00
38.64
N


ATOM
14452
C
GLN
B
408
−53.399
−24.274
−.647
1.00
33.72
C


ATOM
14453
O
GLN
B
408
−52.852
−23.253
−.204
1.00
33.52
O


ATOM
14455
N
ASN
B
409
−52.889
−25.491
−.490
1.00
33.95
N


ATOM
14456
CA
ASN
B
409
−51.642
−25.707
.226
1.00
34.16
C


ATOM
14458
CB
ASN
B
409
−51.865
−26.665
1.391
1.00
34.25
C


ATOM
14461
CG
ASN
B
409
−52.756
−26.069
2.459
1.00
34.39
C


ATOM
14462
OD1
ASN
B
409
−52.269
−25.577
3.480
1.00
34.40
O


ATOM
14463
ND2
ASN
B
409
−54.070
−26.089
2.222
1.00
34.12
N


ATOM
14466
C
ASN
B
409
−50.582
−26.244
−.709
1.00
34.12
C


ATOM
14467
O
ASN
B
409
−50.578
−27.422
−1.046
1.00
34.41
O


ATOM
14469
N
ILE
B
410
−49.681
−25.369
−1.127
1.00
34.07
N


ATOM
14470
CA
ILE
B
410
−48.699
−25.718
−2.138
1.00
34.08
C


ATOM
14472
CB
ILE
B
410
−48.138
−24.455
−2.840
1.00
34.15
C


ATOM
14474
CG1
ILE
B
410
−47.274
−23.610
−1.891
1.00
34.26
C


ATOM
14477
CD1
ILE
B
410
−47.216
−22.139
−2.249
1.00
34.10
C


ATOM
14481
CG2
ILE
B
410
−49.290
−23.634
−3.404
1.00
34.49
C


ATOM
14485
C
ILE
B
410
−47.586
−26.553
−1.533
1.00
33.93
C


ATOM
14486
O
ILE
B
410
−47.181
−26.317
−.405
1.00
33.80
O


ATOM
14488
N
LYS
B
411
−47.123
−27.546
−2.285
1.00
34.12
N


ATOM
14489
CA
LYS
B
411
−46.012
−28.395
−1.874
1.00
34.45
C


ATOM
14491
CB
LYS
B
411
−46.414
−29.873
−1.907
1.00
34.67
C


ATOM
14494
CG
LYS
B
411
−47.850
−30.130
−1.460
1.00
35.79
C


ATOM
14497
CD
LYS
B
411
−48.102
−31.586
−1.052
1.00
37.60
C


ATOM
14500
CE
LYS
B
411
−49.450
−31.728
−.309
1.00
38.80
C


ATOM
14503
NZ
LYS
B
411
−49.568
−32.992
.488
1.00
39.20
N


ATOM
14507
C
LYS
B
411
−44.843
−28.132
−2.810
1.00
34.33
C


ATOM
14508
O
LYS
B
411
−45.038
−27.956
−4.006
1.00
34.14
O


ATOM
14510
N
LYS
B
412
−43.631
−28.102
−2.265
1.00
34.50
N


ATOM
14511
CA
LYS
B
412
−42.460
−27.688
−3.042
1.00
34.69
C


ATOM
14513
CB
LYS
B
412
−41.242
−27.398
−2.154
1.00
35.13
C


ATOM
14516
CG
LYS
B
412
−41.205
−25.960
−1.613
1.00
36.90
C


ATOM
14519
CD
LYS
B
412
−40.079
−25.749
−.588
1.00
38.57
C


ATOM
14522
CE
LYS
B
412
−40.546
−24.852
.555
1.00
39.55
C


ATOM
14525
NZ
LYS
B
412
−39.491
−24.644
1.587
1.00
40.83
N


ATOM
14529
C
LYS
B
412
−42.075
−28.687
−4.103
1.00
34.13
C


ATOM
14530
O
LYS
B
412
−41.468
−28.308
−5.093
1.00
34.21
O


ATOM
14532
N
GLU
B
413
−42.408
−29.958
−3.910
1.00
33.54
N


ATOM
14533
CA
GLU
B
413
−42.095
−30.949
−4.933
1.00
33.19
C


ATOM
14535
CB
GLU
B
413
−41.886
−32.335
−4.330
1.00
33.44
C


ATOM
14538
CG
GLU
B
413
−43.127
−33.037
−3.807
1.00
34.37
C


ATOM
14541
CD
GLU
B
413
−42.834
−34.490
−3.499
1.00
35.56
C


ATOM
14542
OE1
GLU
B
413
−42.662
−35.264
−4.471
1.00
35.30
O


ATOM
14543
OE2
GLU
B
413
−42.751
−34.847
−2.297
1.00
36.69
O


ATOM
14544
C
GLU
B
413
−43.157
−30.965
−6.029
1.00
32.47
C


ATOM
14545
O
GLU
B
413
−42.846
−31.232
−7.193
1.00
32.28
O


ATOM
14547
N
GLU
B
414
−44.403
−30.676
−5.652
1.00
31.58
N


ATOM
14548
CA
GLU
B
414
−45.482
−30.512
−6.614
1.00
30.99
C


ATOM
14550
CB
GLU
B
414
−46.781
−30.101
−5.927
1.00
30.98
C


ATOM
14553
CG
GLU
B
414
−47.732
−31.245
−5.642
1.00
31.82
C


ATOM
14556
CD
GLU
B
414
−49.100
−30.774
−5.138
1.00
34.29
C


ATOM
14557
OE1
GLU
B
414
−49.258
−29.581
−4.777
1.00
35.53
O


ATOM
14558
OE2
GLU
B
414
−50.036
−31.603
−5.101
1.00
36.44
O


ATOM
14559
C
GLU
B
414
−45.104
−29.455
−7.628
1.00
30.59
C


ATOM
14560
O
GLU
B
414
−45.169
−29.687
−8.828
1.00
30.37
O


ATOM
14562
N
ILE
B
415
−44.684
−28.295
−7.140
1.00
30.49
N


ATOM
14563
CA
ILE
B
415
−44.367
−27.177
−8.028
1.00
30.40
C


ATOM
14565
CB
ILE
B
415
−44.412
−25.797
−7.320
1.00
30.40
C


ATOM
14567
CG1
ILE
B
415
−43.235
−25.589
−6.388
1.00
30.36
C


ATOM
14570
CD1
ILE
B
415
−43.373
−24.313
−5.611
1.00
31.01
C


ATOM
14574
CG2
ILE
B
415
−45.686
−25.644
−6.523
1.00
30.85
C


ATOM
14578
C
ILE
B
415
−43.037
−27.347
−8.730
1.00
30.12
C


ATOM
14579
O
ILE
B
415
−42.870
−26.865
−9.840
1.00
30.42
O


ATOM
14581
N
GLU
B
416
−42.095
−28.030
−8.099
1.00
29.75
N


ATOM
14582
CA
GLU
B
416
−40.799
−28.249
−8.719
1.00
29.70
C


ATOM
14584
CB
GLU
B
416
−39.825
−28.777
−7.690
1.00
30.02
C


ATOM
14587
CG
GLU
B
416
−38.386
−28.426
−7.948
1.00
31.20
C


ATOM
14590
CD
GLU
B
416
−37.523
−28.839
−6.776
1.00
32.91
C


ATOM
14591
OE1
GLU
B
416
−38.008
−28.723
−5.632
1.00
32.37
O


ATOM
14592
OE2
GLU
B
416
−36.377
−29.294
−6.994
1.00
35.31
O


ATOM
14593
C
GLU
B
416
−40.917
−29.222
−9.890
1.00
29.24
C


ATOM
14594
O
GLU
B
416
−40.121
−29.177
−10.835
1.00
28.86
O


ATOM
14596
N
ASN
B
417
−41.915
−30.097
−9.819
1.00
28.81
N


ATOM
14597
CA
ASN
B
417
−42.252
−30.960
−10.941
1.00
28.66
C


ATOM
14599
CB
ASN
B
417
−43.165
−32.105
−10.503
1.00
28.72
C


ATOM
14602
CG
ASN
B
417
−42.379
−33.285
−9.973
1.00
29.78
C


ATOM
14603
OD1
ASN
B
417
−41.887
−34.108
−10.744
1.00
30.39
O


ATOM
14604
ND2
ASN
B
417
−42.223
−33.358
−8.653
1.00
31.45
N


ATOM
14607
C
ASN
B
417
−42.888
−30.183
−12.067
1.00
28.32
C


ATOM
14608
O
ASN
B
417
−42.611
−30.456
−13.232
1.00
27.95
O


ATOM
14610
N
LEU
B
418
−43.740
−29.217
−11.713
1.00
28.23
N


ATOM
14611
CA
LEU
B
418
−44.349
−28.313
−12.697
1.00
27.92
C


ATOM
14613
CB
LEU
B
418
−45.298
−27.320
−12.023
1.00
27.48
C


ATOM
14616
CG
LEU
B
418
−46.636
−27.896
−11.553
1.00
27.02
C


ATOM
14618
CD1
LEU
B
418
−47.393
−26.882
−10.691
1.00
26.70
C


ATOM
14622
CD2
LEU
B
418
−47.499
−28.355
−12.720
1.00
25.90
C


ATOM
14626
C
LEU
B
418
−43.275
−27.567
−13.491
1.00
28.20
C


ATOM
14627
O
LEU
B
418
−43.310
−27.541
−14.733
1.00
27.90
O


ATOM
14629
N
GLN
B
419
−42.308
−26.995
−12.770
1.00
28.43
N


ATOM
14630
CA
GLN
B
419
−41.170
−26.315
−13.395
1.00
28.72
C


ATOM
14632
CB
GLN
B
419
−40.223
−25.746
−12.347
1.00
28.81
C


ATOM
14635
CG
GLN
B
419
−40.592
−24.332
−11.946
1.00
30.14
C


ATOM
14638
CD
GLN
B
419
−39.535
−23.671
−11.092
1.00
32.05
C


ATOM
14639
OE1
GLN
B
419
−39.246
−22.477
−11.257
1.00
33.88
O


ATOM
14640
NE2
GLN
B
419
−38.948
−24.437
−10.170
1.00
31.84
N


ATOM
14643
C
GLN
B
419
−40.390
−27.179
−14.370
1.00
28.83
C


ATOM
14644
O
GLN
B
419
−39.922
−26.668
−15.386
1.00
28.72
O


ATOM
14646
N
LYS
B
420
−40.265
−28.475
−14.067
1.00
29.21
N


ATOM
14647
CA
LYS
B
420
−39.613
−29.451
−14.968
1.00
29.26
C


ATOM
14649
CB
LYS
B
420
−38.924
−30.555
−14.143
1.00
29.42
C


ATOM
14652
CG
LYS
B
420
−37.800
−30.052
−13.207
1.00
30.58
C


ATOM
14655
CD
LYS
B
420
−37.373
−31.113
−12.151
1.00
32.35
C


ATOM
14658
CE
LYS
B
420
−36.572
−30.506
−10.955
1.00
33.05
C


ATOM
14661
NZ
LYS
B
420
−36.520
−31.368
−9.702
1.00
32.62
N


ATOM
14665
C
LYS
B
420
−40.579
−30.057
−16.021
1.00
28.96
C


ATOM
14666
O
LYS
B
420
−40.216
−30.965
−16.753
1.00
28.66
O


ATOM
14668
N
TYR
B
421
−41.804
−29.543
−16.088
1.00
29.01
N


ATOM
14669
CA
TYR
B
421
−42.777
−29.893
−17.134
1.00
29.16
C


ATOM
14671
CB
TYR
B
421
−42.209
−29.602
−18.534
1.00
29.48
C


ATOM
14674
CG
TYR
B
421
−41.968
−28.127
−18.773
1.00
31.04
C


ATOM
14675
CD1
TYR
B
421
−43.018
−27.219
−18.716
1.00
32.54
C


ATOM
14677
CE1
TYR
B
421
−42.815
−25.878
−18.914
1.00
33.35
C


ATOM
14679
CZ
TYR
B
421
−41.556
−25.413
−19.193
1.00
34.56
C


ATOM
14680
OH
TYR
B
421
−41.377
−24.066
−19.384
1.00
37.99
O


ATOM
14838
CB
ILE
B
431
−54.400
−31.738
−26.375
1.00
16.53
C


ATOM
14840
CG1
ILE
B
431
−54.225
−33.123
−25.728
1.00
16.06
C


ATOM
14843
CD1
ILE
B
431
−54.069
−34.212
−26.698
1.00
16.05
C


ATOM
14847
CG2
ILE
B
431
−55.701
−31.666
−27.149
1.00
15.49
C


ATOM
14851
C
ILE
B
431
−53.431
−29.949
−27.748
1.00
16.35
C


ATOM
14852
O
ILE
B
431
−53.856
−29.712
−28.860
1.00
16.74
O


ATOM
14854
N
PHE
B
432
−53.110
−29.003
−26.881
1.00
16.15
N


ATOM
14855
CA
PHE
B
432
−53.353
−27.577
−27.145
1.00
16.19
C


ATOM
14857
CB
PHE
B
432
−52.811
−26.776
−25.956
1.00
16.36
C


ATOM
14860
CG
PHE
B
432
−53.007
−25.295
−26.043
1.00
16.54
C


ATOM
14861
CD1
PHE
B
432
−53.869
−24.708
−26.946
1.00
16.55
C


ATOM
14863
CE1
PHE
B
432
−54.007
−23.334
−26.974
1.00
17.89
C


ATOM
14865
CZ
PHE
B
432
−53.305
−22.538
−26.080
1.00
17.96
C


ATOM
14867
CE2
PHE
B
432
−52.461
−23.114
−25.169
1.00
17.30
C


ATOM
14869
CD2
PHE
B
432
−52.323
−24.482
−25.151
1.00
17.54
C


ATOM
14871
C
PHE
B
432
−52.726
−27.104
−28.452
1.00
15.93
C


ATOM
14872
O
PHE
B
432
−53.398
−26.525
−29.303
1.00
15.63
O


ATOM
14874
N
ARG
B
433
−51.438
−27.387
−28.594
1.00
15.79
N


ATOM
14875
CA
ARG
B
433
−50.674
−27.044
−29.778
1.00
15.74
C


ATOM
14877
CB
ARG
B
433
−49.196
−27.279
−29.470
1.00
15.68
C


ATOM
14880
CG
ARG
B
433
−48.259
−27.218
−30.665
1.00
16.39
C


ATOM
14883
CD
ARG
B
433
−48.348
−25.919
−31.388
1.00
16.27
C


ATOM
14886
NE
ARG
B
433
−47.969
−24.850
−30.492
1.00
17.34
N


ATOM
14888
CZ
ARG
B
433
−48.210
−23.565
−30.703
1.00
17.89
C


ATOM
14889
NH1
ARG
B
433
−48.834
−23.142
−31.803
1.00
16.79
N


ATOM
14892
NH2
ARG
B
433
−47.805
−22.701
−29.792
1.00
18.53
N


ATOM
14895
C
ARG
B
433
−51.114
−27.852
−31.011
1.00
15.85
C


ATOM
14896
O
ARG
B
433
−51.197
−27.328
−32.120
1.00
15.40
O


ATOM
14898
N
LEU
B
434
−51.381
−29.134
−30.813
1.00
16.18
N


ATOM
14899
CA
LEU
B
434
−51.794
−29.986
−31.902
1.00
16.58
C


ATOM
14901
CB
LEU
B
434
−51.802
−31.453
−31.468
1.00
16.79
C


ATOM
14904
CG
LEU
B
434
−50.408
−32.055
−31.232
1.00
17.49
C


ATOM
14906
CD1
LEU
B
434
−50.486
−33.548
−30.864
1.00
16.63
C


ATOM
14910
CD2
LEU
B
434
−49.511
−31.836
−32.467
1.00
18.00
C


ATOM
14914
C
LEU
B
434
−53.158
−29.559
−32.423
1.00
17.07
C


ATOM
14915
O
LEU
B
434
−53.333
−29.442
−33.633
1.00
17.44
O


ATOM
14917
N
CYS
B
435
−54.118
−29.308
−31.532
1.00
17.23
N


ATOM
14918
CA
CYS
B
435
−55.419
−28.778
−31.947
1.00
17.44
C


ATOM
14920
CB
CYS
B
435
−56.301
−28.529
−30.746
1.00
17.38
C


ATOM
14923
SG
CYS
B
435
−56.825
−29.993
−29.971
1.00
17.90
S


ATOM
14925
C
CYS
B
435
−55.295
−27.460
−32.696
1.00
17.78
C


ATOM
14926
O
CYS
B
435
−55.978
−27.232
−33.701
1.00
17.44
O


ATOM
14928
N
ASN
B
436
−54.442
−26.585
−32.178
1.00
18.31
N


ATOM
14929
CA
ASN
B
436
−54.248
−25.267
−32.769
1.00
19.14
C


ATOM
14931
CB
ASN
B
436
−53.392
−24.394
−31.844
1.00
19.31
C


ATOM
14934
CG
ASN
B
436
−52.984
−23.068
−32.478
1.00
20.07
C


ATOM
14935
OD1
ASN
B
436
−53.456
−22.686
−33.555
1.00
22.72
O


ATOM
14936
ND2
ASN
B
436
−52.099
−22.356
−31.800
1.00
20.90
N


ATOM
14939
C
ASN
B
436
−53.615
−25.345
−34.157
1.00
19.51
C


ATOM
14940
O
ASN
B
436
−54.173
−24.840
−35.131
1.00
19.79
O


ATOM
14942
N
ASP
B
437
−52.446
−25.965
−34.245
1.00
19.85
N


ATOM
14943
CA
ASP
B
437
−51.754
−26.058
−35.517
1.00
20.01
C


ATOM
14945
CB
ASP
B
437
−50.340
−26.638
−35.331
1.00
20.00
C


ATOM
14948
CG
ASP
B
437
−49.397
−25.675
−34.557
1.00
21.23
C


ATOM
14949
OD1
ASP
B
437
−49.902
−24.749
−33.877
1.00
22.90
O


ATOM
14950
OD2
ASP
B
437
−48.149
−25.821
−34.632
1.00
22.18
O


ATOM
14951
C
ASP
B
437
−52.629
−26.838
−36.512
1.00
20.00
C


ATOM
14952
O
ASP
B
437
−52.678
−26.491
−37.695
1.00
20.02
O


ATOM
14954
N
LEU
B
438
−53.372
−27.836
−36.021
1.00
20.02
N


ATOM
14955
CA
LEU
B
438
−54.352
−28.558
−36.858
1.00
20.18
C


ATOM
14957
CB
LEU
B
438
−55.144
−29.593
−36.049
1.00
19.88
C


ATOM
14960
CG
LEU
B
438
−54.699
−31.050
−36.142
1.00
18.97
C


ATOM
14962
CD1
LEU
B
438
−55.537
−31.869
−35.200
1.00
18.86
C


ATOM
14966
CD2
LEU
B
438
−54.818
−31.585
−37.550
1.00
16.23
C


ATOM
14970
C
LEU
B
438
−55.358
−27.644
−37.564
1.00
20.60
C


ATOM
14971
O
LEU
B
438
−55.717
−27.889
−38.712
1.00
20.30
O


ATOM
14973
N
ALA
B
439
−55.825
−26.620
−36.853
1.00
21.39
N


ATOM
14974
CA
ALA
B
439
−56.802
−25.654
−37.377
1.00
21.96
C


ATOM
14976
CB
ALA
B
439
−57.306
−24.741
−36.242
1.00
21.77
C


ATOM
14980
C
ALA
B
439
−56.214
−24.805
−38.494
1.00
22.47
C


ATOM
14981
O
ALA
B
439
−56.850
−24.559
−39.517
1.00
22.13
O


ATOM
14983
N
SER
B
440
−54.983
−24.370
−38.282
1.00
23.40
N


ATOM
14984
CA
SER
B
440
−54.337
−23.428
−39.169
1.00
24.40
C


ATOM
14986
CB
SER
B
440
−53.423
−22.529
−38.342
1.00
24.44
C


ATOM
14989
OG
SER
B
440
−52.994
−23.206
−37.166
1.00
25.19
O


ATOM
14991
C
SER
B
440
−53.544
−24.103
−40.289
1.00
25.15
C


ATOM
14992
O
SER
B
440
−53.093
−23.424
−41.210
1.00
25.24
O


ATOM
14994
N
ALA
B
441
−53.392
−25.428
−40.222
1.00
25.99
N


ATOM
14995
CA
ALA
B
441
−52.488
−26.160
−41.119
1.00
26.53
C


ATOM
14997
CB
ALA
B
441
−52.532
−27.655
−40.830
1.00
26.26
C


ATOM
15001
C
ALA
B
441
−52.726
−25.903
−42.608
1.00
27.31
C


ATOM
15002
O
ALA
B
441
−51.811
−25.489
−43.310
1.00
27.26
O


ATOM
15004
N
SER
B
442
−53.940
−26.134
−43.098
1.00
28.45
N


ATOM
15005
CA
SER
B
442
−54.138
−26.138
−44.545
1.00
29.47
C


ATOM
15007
CB
SER
B
442
−55.477
−26.769
−44.936
1.00
29.40
C


ATOM
15010
OG
SER
B
442
−56.454
−25.784
−45.181
1.00
30.36
O


ATOM
15012
C
SER
B
442
−53.966
−24.731
−45.125
1.00
30.22
C


ATOM
15013
O
SER
B
442
−53.304
−24.562
−46.139
1.00
30.26
O


ATOM
15015
N
ALA
B
443
−54.537
−23.729
−44.467
1.00
31.38
N


ATOM
15016
CA
ALA
B
443
−54.308
−22.333
−44.835
1.00
32.22
C


ATOM
15018
CB
ALA
B
443
−55.057
−21.410
−43.893
1.00
32.28
C


ATOM
15022
C
ALA
B
443
−52.820
−21.992
−44.818
1.00
33.12
C


ATOM
15023
O
ALA
B
443
−52.302
−21.419
−45.766
1.00
33.24
O


ATOM
15025
N
GLU
B
444
−52.136
−22.351
−43.736
1.00
34.43
N


ATOM
15026
CA
GLU
B
444
−50.711
−22.033
−43.582
1.00
35.35
C


ATOM
15028
CB
GLU
B
444
−50.237
−22.271
−42.134
1.00
35.46
C


ATOM
15031
CG
GLU
B
444
−50.757
−21.227
−41.126
1.00
36.42
C


ATOM
15034
CD
GLU
B
444
−50.178
−21.376
−39.708
1.00
37.82
C


ATOM
15035
OE1
GLU
B
444
−49.965
−22.506
−39.224
1.00
37.92
O


ATOM
15036
OE2
GLU
B
444
−49.955
−20.344
−39.049
1.00
40.09
O


ATOM
15037
C
GLU
B
444
−49.840
−22.794
−44.594
1.00
35.87
C


ATOM
15038
O
GLU
B
444
−48.870
−22.239
−45.107
1.00
35.85
O


ATOM
15040
N
ILE
B
445
−50.193
−24.048
−44.883
1.00
36.63
N


ATOM
15041
CA
ILE
B
445
−49.517
−24.837
−45.928
1.00
37.21
C


ATOM
15043
CB
ILE
B
445
−49.854
−26.366
−45.832
1.00
37.15
C


ATOM
15045
CG1
ILE
B
445
−49.181
−26.991
−44.609
1.00
36.85
C


ATOM
15048
CD1
ILE
B
445
−49.867
−28.244
−44.102
1.00
36.62
C


ATOM
15052
CG2
ILE
B
445
−49.416
−27.120
−47.093
1.00
36.66
C


ATOM
15056
C
ILE
B
445
−49.933
−24.289
−47.290
1.00
37.88
C


ATOM
15057
O
ILE
B
445
−50.926
−24.733
−47.874
1.00
38.20
O


ATOM
15059
N
ALA
B
446
−49.175
−23.314
−47.785
1.00
38.56
N


ATOM
15060
CA
ALA
B
446
−49.544
−22.575
−48.992
1.00
39.03
C


ATOM
15062
CB
ALA
B
446
−49.833
−23.522
−50.169
1.00
39.19
C


ATOM
15066
C
ALA
B
446
−50.768
−21.740
−48.685
1.00
39.42
C


ATOM
15067
O
ALA
B
446
−51.866
−22.288
−48.742
1.00
39.26
O


ATOM
15069
N
ARG
B
447
−50.650
−20.443
−48.361
1.00
40.06
N


ATOM
15070
CA
ARG
B
447
−49.426
−19.589
−48.361
1.00
40.54
C


ATOM
15072
CB
ARG
B
447
−49.276
−18.901
−46.986
1.00
40.70
C


ATOM
15075
CG
ARG
B
447
−50.121
−17.634
−46.836
1.00
41.82
C


ATOM
15078
CD
ARG
B
447
−50.292
−17.234
−45.377
1.00
42.99
C


ATOM
15081
NE
ARG
B
447
−51.628
−17.546
−44.864
1.00
44.22
N


ATOM
15083
CZ
ARG
B
447
−51.924
−17.766
−43.580
1.00
46.00
C


ATOM
15084
NH1
ARG
B
447
−50.977
−17.730
−42.633
1.00
46.34
N


ATOM
15087
NH2
ARG
B
447
−53.184
−18.039
−43.236
1.00
46.39
N


ATOM
15090
C
ARG
B
447
−48.095
−20.208
−48.837
1.00
40.35
C


ATOM
15091
O
ARG
B
447
−47.897
−20.403
−50.038
1.00
40.95
O


ATOM
15093
N
GLY
B
448
−47.170
−20.442
−47.918
1.00
39.87
N


ATOM
15094
CA
GLY
B
448
−46.020
−21.306
−48.162
1.00
39.52
C


ATOM
15097
C
GLY
B
448
−45.258
−21.517
−46.865
1.00
39.26
C


ATOM
15098
O
GLY
B
448
−44.071
−21.842
−46.885
1.00
39.15
O


ATOM
15100
N
GLU
B
449
−45.966
−21.344
−45.742
1.00
38.85
N


ATOM
15101
CA
GLU
B
449
−45.365
−21.215
−44.426
1.00
38.45
C


ATOM
15103
CB
GLU
B
449
−46.288
−20.472
−43.444
1.00
38.76
C


ATOM
15106
CG
GLU
B
449
−46.346
−18.943
−43.636
1.00
40.34
C


ATOM
15109
CD
GLU
B
449
−47.486
−18.257
−42.839
1.00
42.09
C


ATOM
15110
OE1
GLU
B
449
−47.897
−18.787
−41.780
1.00
43.23
O


ATOM
15111
OE2
GLU
B
449
−47.972
−17.184
−43.274
1.00
42.13
O


ATOM
15112
C
GLU
B
449
−45.073
−22.600
−43.906
1.00
37.54
C


ATOM
15113
O
GLU
B
449
−45.810
−23.553
−44.167
1.00
37.34
O


ATOM
15115
N
THR
B
450
−43.986
−22.688
−43.159
1.00
36.47
N


ATOM
15116
CA
THR
B
450
−43.459
−23.950
−42.702
1.00
35.65
C


ATOM
15118
CB
THR
B
450
−42.017
−24.105
−43.245
1.00
35.81
C


ATOM
15120
OG1
THR
B
450
−41.593
−25.465
−43.109
1.00
37.67
O


ATOM
15122
CG2
THR
B
450
−41.029
−23.152
−42.538
1.00
36.21
C


ATOM
15126
C
THR
B
450
−43.528
−24.084
−41.166
1.00
34.22
C


ATOM
15127
O
THR
B
450
−43.165
−25.127
−40.619
1.00
34.00
O


ATOM
15129
N
ALA
B
451
−44.024
−23.034
−40.495
1.00
32.69
N


ATOM
15130
CA
ALA
B
451
−44.144
−22.974
−39.026
1.00
31.28
C


ATOM
15132
CB
ALA
B
451
−43.952
−21.546
−38.545
1.00
31.06
C


ATOM
15136
C
ALA
B
451
−45.495
−23.500
−38.547
1.00
29.97
C


ATOM
15137
O
ALA
B
451
−46.337
−22.735
−38.082
1.00
30.08
O


ATOM
15139
N
ASN
B
452
−45.690
−24.809
−38.656
1.00
28.19
N


ATOM
15140
CA
ASN
B
452
−46.935
−25.444
−38.272
1.00
26.73
C


ATOM
15142
CB
ASN
B
452
−47.929
−25.339
−39.422
1.00
26.45
C


ATOM
15145
CG
ASN
B
452
−49.311
−25.832
−39.057
1.00
25.38
C


ATOM
15146
OD1
ASN
B
452
−49.608
−27.004
−39.195
1.00
24.57
O


ATOM
15147
ND2
ASN
B
452
−50.171
−24.928
−38.618
1.00
24.44
N


ATOM
15150
C
ASN
B
452
−46.631
−26.889
−37.952
1.00
26.05
C


ATOM
15151
O
ASN
B
452
−45.930
−27.544
−38.695
1.00
26.21
O


ATOM
15153
N
SER
B
453
−47.131
−27.388
−36.834
1.00
25.30
N


ATOM
15154
CA
SER
B
453
−46.843
−28.760
−36.432
1.00
24.72
C


ATOM
15156
CB
SER
B
453
−47.638
−29.139
−35.174
1.00
24.81
C


ATOM
15159
OG
SER
B
453
−47.143
−28.455
−34.031
1.00
24.36
O


ATOM
15161
C
SER
B
453
−47.111
−29.770
−37.543
1.00
24.12
C


ATOM
15162
O
SER
B
453
−46.325
−30.679
−37.743
1.00
24.33
O


ATOM
15164
N
VAL
B
454
−48.202
−29.606
−38.272
1.00
23.57
N


ATOM
15165
CA
VAL
B
454
−48.546
−30.541
−39.328
1.00
23.27
C


ATOM
15167
CB
VAL
B
454
−50.001
−30.361
−39.795
1.00
23.06
C


ATOM
15169
CG1
VAL
B
454
−50.363
−31.385
−40.829
1.00
22.41
C


ATOM
15173
CG2
VAL
B
454
−50.946
−30.489
−38.622
1.00
22.80
C


ATOM
15177
C
VAL
B
454
−47.581
−30.473
−40.521
1.00
23.83
C


ATOM
15178
O
VAL
B
454
−47.370
−31.493
−41.175
1.00
24.48
O


ATOM
15180
N
SER
B
455
−46.981
−29.309
−40.803
1.00
23.99
N


ATOM
15181
CA
SER
B
455
−45.978
−29.198
−41.881
1.00
24.22
C


ATOM
15183
CB
SER
B
455
−45.577
−27.767
−42.111
1.00
24.02
C


ATOM
15186
OG
SER
B
455
−46.655
−27.098
−42.689
1.00
25.57
O


ATOM
15188
C
SER
B
455
−44.708
−29.949
−41.582
1.00
24.65
C


ATOM
15189
O
SER
B
455
−44.211
−30.700
−42.417
1.00
25.23
O


ATOM
15191
N
CYS
B
456
−44.151
−29.700
−40.405
1.00
24.82
N


ATOM
15192
CA
CYS
B
456
−43.024
−30.462
−39.935
1.00
24.81
C


ATOM
15194
CB
CYS
B
456
−42.765
−30.170
−38.470
1.00
24.92
C


ATOM
15197
SG
CYS
B
456
−42.139
−28.541
−38.190
1.00
25.18
S


ATOM
15199
C
CYS
B
456
−43.304
−31.938
−40.124
1.00
24.84
C


ATOM
15200
O
CYS
B
456
−42.507
−32.634
−40.728
1.00
25.34
O


ATOM
15202
N
TYR
B
457
−44.442
−32.421
−39.644
1.00
24.75
N


ATOM
15203
CA
TYR
B
457
−44.735
−33.838
−39.778
1.00
24.85
C


ATOM
15205
CB
TYR
B
457
−46.069
−34.197
−39.142
1.00
24.64
C


ATOM
15208
CG
TYR
B
457
−46.057
−35.537
−38.451
1.00
24.00
C


ATOM
15209
CD1
TYR
B
457
−45.846
−35.635
−37.083
1.00
24.19
C


ATOM
15211
CE1
TYR
B
457
−45.848
−36.873
−36.436
1.00
23.72
C


ATOM
15213
CZ
TYR
B
457
−46.059
−38.025
−37.170
1.00
23.27
C


ATOM
15214
OH
TYR
B
457
−46.063
−39.244
−36.554
1.00
22.94
O


ATOM
15216
CE2
TYR
B
457
−46.268
−37.961
−38.528
1.00
23.68
C


ATOM
15218
CD2
TYR
B
457
−46.265
−36.711
−39.163
1.00
24.16
C


ATOM
15220
C
TYR
B
457
−44.676
−34.267
−41.251
1.00
25.30
C


ATOM
15221
O
TYR
B
457
−43.965
−35.208
−41.584
1.00
24.94
O


ATOM
15223
N
MET
B
458
−45.388
−33.569
−42.134
1.00
26.02
N


ATOM
15224
CA
MET
B
458
−45.207
−33.775
−43.585
1.00
26.76
C


ATOM
15226
CB
MET
B
458
−45.913
−32.685
−44.407
1.00
26.84
C


ATOM
15229
CG
MET
B
458
−47.419
−32.720
−44.429
1.00
27.32
C


ATOM
15232
SD
MET
B
458
−48.092
−31.238
−45.229
1.00
27.76
S


ATOM
15233
CE
MET
B
458
−47.283
−31.311
−46.830
1.00
26.95
C


ATOM
15237
C
MET
B
458
−43.723
−33.759
−43.996
1.00
27.06
C


ATOM
15238
O
MET
B
458
−43.192
−34.746
−44.485
1.00
26.94
O


ATOM
15240
N
ARG
B
459
−43.069
−32.624
−43.800
1.00
27.58
N


ATOM
15241
CA
ARG
B
459
−41.720
−32.419
−44.289
1.00
28.38
C


ATOM
15243
CB
ARG
B
459
−41.313
−30.965
−44.041
1.00
28.96
C


ATOM
15246
CG
ARG
B
459
−39.862
−30.642
−44.328
1.00
31.93
C


ATOM
15249
CD
ARG
B
459
−39.656
−29.139
−44.480
1.00
36.88
C


ATOM
15252
NE
ARG
B
459
−40.318
−28.349
−43.427
1.00
41.70
N


ATOM
15254
CZ
ARG
B
459
−39.890
−28.241
−42.161
1.00
45.68
C


ATOM
15255
NH1
ARG
B
459
−38.795
−28.899
−41.751
1.00
48.08
N


ATOM
15258
NH2
ARG
B
459
−40.566
−27.489
−41.284
1.00
45.92
N


ATOM
15261
C
ARG
B
459
−40.717
−33.401
−43.672
1.00
28.03
C


ATOM
15262
O
ARG
B
459
−39.829
−33.881
−44.356
1.00
28.13
O


ATOM
15264
N
THR
B
460
−40.882
−33.711
−42.393
1.00
27.88
N


ATOM
15265
CA
THR
B
460
−40.002
−34.635
−41.664
1.00
27.75
C


ATOM
15267
CB
THR
B
460
−40.240
−34.502
−40.134
1.00
27.79
C


ATOM
15269
OG1
THR
B
460
−39.805
−33.209
−39.689
1.00
27.98
O


ATOM
15271
CG2
THR
B
460
−39.519
−35.589
−39.356
1.00
27.46
C


ATOM
15275
C
THR
B
460
−40.171
−36.114
−42.045
1.00
27.72
C


ATOM
15276
O
THR
B
460
−39.211
−36.857
−42.069
1.00
27.60
O


ATOM
15278
N
LYS
B
461
−41.398
−36.538
−42.313
1.00
28.05
N


ATOM
15279
CA
LYS
B
461
−41.701
−37.929
−42.649
1.00
28.25
C


ATOM
15281
CB
LYS
B
461
−42.972
−38.381
−41.914
1.00
28.32
C


ATOM
15284
CG
LYS
B
461
−42.767
−38.763
−40.453
1.00
28.57
C


ATOM
15287
CD
LYS
B
461
−42.569
−40.271
−40.299
1.00
29.79
C


ATOM
15290
CE
LYS
B
461
−41.913
−40.651
−38.970
1.00
30.32
C


ATOM
15293
NZ
LYS
B
461
−42.651
−40.184
−37.749
1.00
30.60
N


ATOM
15297
C
LYS
B
461
−41.876
−38.139
−44.155
1.00
28.50
C


ATOM
15298
O
LYS
B
461
−42.071
−39.269
−44.598
1.00
28.58
O


ATOM
15300
N
GLY
B
462
−41.818
−37.057
−44.933
1.00
28.79
N


ATOM
15301
CA
GLY
B
462
−41.978
−37.114
−46.385
1.00
29.04
C


ATOM
15304
C
GLY
B
462
−43.333
−37.610
−46.853
1.00
29.39
C


ATOM
15305
O
GLY
B
462
−43.410
−38.452
−47.738
1.00
29.53
O


ATOM
15307
N
ILE
B
463
−44.406
−37.081
−46.270
1.00
29.91
N


ATOM
15308
CA
ILE
B
463
−45.764
−37.552
−46.572
1.00
30.27
C


ATOM
15310
CB
ILE
B
463
−46.333
−38.444
−45.433
1.00
30.13
C


ATOM
15312
CG1
ILE
B
463
−46.308
−37.706
−44.092
1.00
30.22
C


ATOM
15315
CD1
ILE
B
463
−46.983
−38.462
−42.965
1.00
30.14
C


ATOM
15319
CG2
ILE
B
463
−45.558
−39.740
−45.340
1.00
29.85
C


ATOM
15323
C
ILE
B
463
−46.775
−36.429
−46.881
1.00
30.75
C


ATOM
15324
O
ILE
B
463
−46.595
−35.270
−46.495
1.00
30.52
O


ATOM
15326
N
SER
B
464
−47.842
−36.822
−47.581
1.00
31.33
N


ATOM
15327
CA
SER
B
464
−48.951
−35.944
−47.952
1.00
31.68
C


ATOM
15329
CB
SER
B
464
−49.948
−36.709
−48.830
1.00
32.02
C


ATOM
15332
OG
SER
B
464
−50.547
−37.793
−48.123
1.00
32.84
O


ATOM
15334
C
SER
B
464
−49.705
−35.396
−46.747
1.00
31.62
C


ATOM
15335
O
SER
B
464
−49.897
−36.097
−45.747
1.00
31.69
O


ATOM
15337
N
GLU
B
465
−50.165
−34.153
−46.874
1.00
31.42
N


ATOM
15338
CA
GLU
B
465
−50.881
−33.466
−45.803
1.00
31.20
C


ATOM
15340
CB
GLU
B
465
−51.465
−32.141
−46.324
1.00
31.33
C


ATOM
15343
CG
GLU
B
465
−52.441
−31.455
−45.359
1.00
31.42
C


ATOM
15346
CD
GLU
B
465
−52.768
−30.006
−45.712
1.00
31.30
C


ATOM
15347
OE1
GLU
B
465
−52.325
−29.490
−46.765
1.00
30.56
O


ATOM
15348
OE2
GLU
B
465
−53.487
−29.380
−44.906
1.00
31.84
O


ATOM
15349
C
GLU
B
465
−51.985
−34.325
−45.202
1.00
30.97
C


ATOM
15350
O
GLU
B
465
−52.175
−34.327
−43.992
1.00
30.72
O


ATOM
15352
N
GLU
B
466
−52.709
−35.052
−46.055
1.00
30.98
N


ATOM
15353
CA
GLU
B
466
−53.865
−35.833
−45.618
1.00
30.65
C


ATOM
15355
CB
GLU
B
466
−54.553
−36.541
−46.788
1.00
30.62
C


ATOM
15358
CG
GLU
B
466
−55.733
−37.401
−46.336
1.00
31.50
C


ATOM
15361
CD
GLU
B
466
−56.353
−38.240
−47.446
1.00
33.14
C


ATOM
15362
OE1
GLU
B
466
−56.512
−37.736
−48.581
1.00
34.40
O


ATOM
15363
OE2
GLU
B
466
−56.699
−39.413
−47.173
1.00
33.21
O


ATOM
15364
C
GLU
B
466
−53.477
−36.851
−44.564
1.00
30.17
C


ATOM
15365
O
GLU
B
466
−54.215
−37.049
−43.606
1.00
30.46
O


ATOM
15367
N
LEU
B
467
−52.333
−37.506
−44.726
1.00
29.59
N


ATOM
15368
CA
LEU
B
467
−51.953
−38.540
−43.769
1.00
29.19
C


ATOM
15370
CB
LEU
B
467
−51.640
−39.869
−44.476
1.00
29.27
C


ATOM
15373
CG
LEU
B
467
−50.356
−40.081
−45.268
1.00
29.84
C


ATOM
15375
CD1
LEU
B
467
−49.341
−40.761
−44.357
1.00
31.06
C


ATOM
15379
CD2
LEU
B
467
−50.589
−40.920
−46.523
1.00
29.47
C


ATOM
15383
C
LEU
B
467
−50.865
−38.092
−42.794
1.00
28.54
C


ATOM
15384
O
LEU
B
467
−50.490
−38.834
−41.894
1.00
28.28
O


ATOM
15386
N
ALA
B
468
−50.388
−36.862
−42.962
1.00
28.04
N


ATOM
15387
CA
ALA
B
468
−49.682
−36.158
−41.893
1.00
27.54
C


ATOM
15389
CB
ALA
B
468
−48.922
−34.970
−42.435
1.00
27.34
C


ATOM
15393
C
ALA
B
468
−50.711
−35.698
−40.865
1.00
27.17
C


ATOM
15394
O
ALA
B
468
−50.482
−35.801
−39.662
1.00
27.40
O


ATOM
15396
N
THR
B
469
−51.841
−35.182
−41.349
1.00
26.57
N


ATOM
15397
CA
THR
B
469
−52.957
−34.795
−40.490
1.00
25.87
C


ATOM
15399
CB
THR
B
469
−54.130
−34.297
−41.328
1.00
25.53
C


ATOM
15401
OG1
THR
B
469
−53.737
−33.111
−42.025
1.00
24.99
O


ATOM
15403
CG2
THR
B
469
−55.316
−33.993
−40.453
1.00
24.62
C


ATOM
15407
C
THR
B
469
−53.412
−35.988
−39.669
1.00
25.95
C


ATOM
15408
O
THR
B
469
−53.551
−35.925
−38.450
1.00
25.80
O


ATOM
15410
N
GLU
B
470
−53.618
−37.091
−40.367
1.00
26.06
N


ATOM
15411
CA
GLU
B
470
−54.043
−38.344
−39.756
1.00
26.10
C


ATOM
15413
CB
GLU
B
470
−54.057
−39.436
−40.848
1.00
26.60
C


ATOM
15416
CG
GLU
B
470
−55.038
−40.587
−40.646
1.00
28.01
C


ATOM
15419
CD
GLU
B
470
−54.553
−41.897
−41.286
1.00
29.05
C


ATOM
15420
OE1
GLU
B
470
−54.298
−41.930
−42.515
1.00
27.96
O


ATOM
15421
OE2
GLU
B
470
−54.435
−42.892
−40.536
1.00
30.42
O


ATOM
15422
C
GLU
B
470
−53.148
−38.746
−38.557
1.00
25.28
C


ATOM
15423
O
GLU
B
470
−53.629
−39.266
−37.556
1.00
25.08
O


ATOM
15425
N
SER
B
471
−51.850
−38.497
−38.654
1.00
24.70
N


ATOM
15426
CA
SER
B
471
−50.930
−38.906
−37.599
1.00
24.26
C


ATOM
15428
CB
SER
B
471
−49.494
−38.842
−38.085
1.00
24.11
C


ATOM
15431
OG
SER
B
471
−49.315
−39.693
−39.186
1.00
23.98
O


ATOM
15433
C
SER
B
471
−51.085
−38.029
−36.377
1.00
23.92
C


ATOM
15434
O
SER
B
471
−51.240
−38.530
−35.270
1.00
24.09
O


ATOM
15436
N
VAL
B
472
−51.032
−36.719
−36.582
1.00
23.48
N


ATOM
15437
CA
VAL
B
472
−51.279
−35.774
−35.510
1.00
23.15
C


ATOM
15439
CB
VAL
B
472
−51.377
−34.332
−36.045
1.00
23.03
C


ATOM
15441
CG1
VAL
B
472
−51.739
−33.347
−34.929
1.00
21.74
C


ATOM
15445
CG2
VAL
B
472
−50.067
−33.945
−36.728
1.00
22.27
C


ATOM
15449
C
VAL
B
472
−52.572
−36.192
−34.830
1.00
23.49
C


ATOM
15450
O
VAL
B
472
−52.663
−36.276
−33.614
1.00
23.29
O


ATOM
15452
N
MET
B
473
−53.573
−36.508
−35.626
1.00
24.34
N


ATOM
15453
CA
MET
B
473
−54.850
−36.901
−35.070
1.00
24.93
C


ATOM
15455
CB
MET
B
473
−55.816
−37.266
−36.190
1.00
25.09
C


ATOM
15458
CG
MET
B
473
−57.191
−36.788
−35.912
1.00
26.94
C


ATOM
15461
SD
MET
B
473
−57.328
−35.035
−36.251
1.00
29.69
S


ATOM
15462
CE
MET
B
473
−58.316
−35.080
−37.775
1.00
29.12
C


ATOM
15466
C
MET
B
473
−54.668
−38.072
−34.100
1.00
25.00
C


ATOM
15467
O
MET
B
473
−55.135
−38.018
−32.963
1.00
24.78
O


ATOM
15469
N
ASN
B
474
−53.965
−39.110
−34.556
1.00
25.30
N


ATOM
15470
CA
ASN
B
474
−53.681
−40.293
−33.738
1.00
25.55
C


ATOM
15472
CB
ASN
B
474
−53.143
−41.439
−34.601
1.00
25.82
C


ATOM
15475
CG
ASN
B
474
−54.243
−42.137
−35.402
1.00
27.62
C


ATOM
15476
OD1
ASN
B
474
−54.238
−42.102
−36.638
1.00
29.33
O


ATOM
15477
ND2
ASN
B
474
−55.196
−42.780
−34.697
1.00
28.58
N


ATOM
15480
C
ASN
B
474
−52.711
−40.034
−32.592
1.00
25.20
C


ATOM
15481
O
ASN
B
474
−52.711
−40.773
−31.621
1.00
25.71
O


ATOM
15483
N
LEU
B
475
−51.883
−38.999
−32.704
1.00
24.65
N


ATOM
15484
CA
LEU
B
475
−50.987
−38.595
−31.614
1.00
24.04
C


ATOM
15486
CB
LEU
B
475
−49.939
−37.626
−32.142
1.00
23.88
C


ATOM
15489
CG
LEU
B
475
−48.837
−37.285
−31.164
1.00
23.70
C


ATOM
15491
CD1
LEU
B
475
−47.936
−38.471
−31.004
1.00
23.97
C


ATOM
15495
CD2
LEU
B
475
−48.088
−36.104
−31.679
1.00
23.99
C


ATOM
15499
C
LEU
B
475
−51.747
−37.940
−30.453
1.00
23.65
C


ATOM
15500
O
LEU
B
475
−51.323
−38.014
−29.299
1.00
23.74
O


ATOM
15502
N
ILE
B
476
−52.858
−37.282
−30.766
1.00
23.15
N


ATOM
15503
CA
ILE
B
476
−53.728
−36.711
−29.742
1.00
22.50
C


ATOM
15505
CB
ILE
B
476
−54.779
−35.755
−30.359
1.00
22.27
C


ATOM
15507
CG1
ILE
B
476
−54.099
−34.508
−30.910
1.00
20.55
C


ATOM
15510
CD1
ILE
B
476
−55.000
−33.671
−31.693
1.00
19.19
C


ATOM
15514
CG2
ILE
B
476
−55.817
−35.363
−29.336
1.00
22.15
C


ATOM
15518
C
ILE
B
476
−54.398
−37.849
−28.985
1.00
22.40
C


ATOM
15519
O
ILE
B
476
−54.316
−37.900
−27.767
1.00
22.32
O


ATOM
15521
N
ASP
B
477
−55.023
−38.777
−29.708
1.00
22.37
N


ATOM
15522
CA
ASP
B
477
−55.616
−39.975
−29.090
1.00
22.55
C


ATOM
15524
CB
ASP
B
477
−55.996
−41.007
−30.151
1.00
22.67
C


ATOM
15527
CG
ASP
B
477
−57.262
−40.636
−30.892
1.00
24.93
C


ATOM
15528
OD1
ASP
B
477
−57.690
−39.458
−30.818
1.00
28.87
O


ATOM
15529
OD2
ASP
B
477
−57.847
−41.523
−31.549
1.00
27.92
O


ATOM
15530
C
ASP
B
477
−54.675
−40.622
−28.083
1.00
22.10
C


ATOM
15531
O
ASP
B
477
−55.048
−40.877
−26.938
1.00
21.83
O


ATOM
15533
N
GLU
B
478
−53.444
−40.867
−28.510
1.00
21.73
N


ATOM
15534
CA
GLU
B
478
−52.472
−41.506
−27.645
1.00
21.69
C


ATOM
15536
CB
GLU
B
478
−51.233
−41.920
−28.437
1.00
21.97
C


ATOM
15539
CG
GLU
B
478
−50.786
−43.360
−28.150
1.00
24.18
C


ATOM
15542
CD
GLU
B
478
−51.793
−44.429
−28.618
1.00
27.03
C


ATOM
15543
OE1
GLU
B
478
−51.599
−45.627
−28.285
1.00
29.15
O


ATOM
15544
OE2
GLU
B
478
−52.770
−44.080
−29.323
1.00
28.37
O


ATOM
15545
C
GLU
B
478
−52.107
−40.608
−26.449
1.00
20.97
C


ATOM
15546
O
GLU
B
478
−51.928
−41.110
−25.316
1.00
21.15
O


ATOM
15548
N
THR
B
479
−52.031
−39.291
−26.687
1.00
19.82
N


ATOM
15549
CA
THR
B
479
−51.787
−38.319
−25.604
1.00
18.59
C


ATOM
15551
CB
THR
B
479
−51.587
−36.897
−26.129
1.00
17.95
C


ATOM
15553
OG1
THR
B
479
−50.291
−36.779
−26.712
1.00
17.43
O


ATOM
15555
CG2
THR
B
479
−51.654
−35.938
−25.009
1.00
17.90
C


ATOM
15559
C
THR
B
479
−52.927
−38.342
−24.580
1.00
18.16
C


ATOM
15560
O
THR
B
479
−52.695
−38.339
−23.383
1.00
18.06
O


ATOM
15562
N
TRP
B
480
−54.160
−38.390
−25.057
1.00
17.77
N


ATOM
15563
CA
TRP
B
480
−55.301
−38.493
−24.169
1.00
17.54
C


ATOM
15565
CB
TRP
B
480
−56.605
−38.464
−24.970
1.00
17.49
C


ATOM
15568
CG
TRP
B
480
−57.239
−37.099
−25.028
1.00
17.53
C


ATOM
15569
CD1
TRP
B
480
−57.150
−36.186
−26.041
1.00
17.04
C


ATOM
15571
NE1
TRP
B
480
−57.857
−35.067
−25.721
1.00
16.57
N


ATOM
15573
CE2
TRP
B
480
−58.423
−35.236
−24.484
1.00
16.41
C


ATOM
15574
CD2
TRP
B
480
−58.055
−36.498
−24.020
1.00
16.68
C


ATOM
15575
CE3
TRP
B
480
−58.507
−36.914
−22.765
1.00
16.92
C


ATOM
15577
CZ3
TRP
B
480
−59.300
−36.076
−22.039
1.00
16.97
C


ATOM
15579
CH2
TRP
B
480
−59.654
−34.823
−22.524
1.00
16.91
C


ATOM
15581
CZ2
TRP
B
480
−59.223
−34.383
−23.742
1.00
16.89
C


ATOM
15583
C
TRP
B
480
−55.232
−39.760
−23.334
1.00
17.75
C


ATOM
15584
O
TRP
B
480
−55.582
−39.747
−22.164
1.00
17.74
O


ATOM
15586
N
LYS
B
481
−54.784
−40.861
−23.933
1.00
18.09
N


ATOM
15587
CA
LYS
B
481
−54.721
−42.124
−23.210
1.00
18.10
C


ATOM
15589
CB
LYS
B
481
−54.277
−43.282
−24.115
1.00
18.01
C


ATOM
15592
CG
LYS
B
481
−55.311
−43.803
−25.114
1.00
16.89
C


ATOM
15595
CD
LYS
B
481
−54.613
−44.663
−26.199
1.00
15.83
C


ATOM
15598
CE
LYS
B
481
−55.587
−45.500
−27.025
1.00
14.74
C


ATOM
15601
NZ
LYS
B
481
−55.119
−45.725
−28.413
1.00
12.34
N


ATOM
15605
C
LYS
B
481
−53.750
−41.970
−22.054
1.00
18.46
C


ATOM
15606
O
LYS
B
481
−53.976
−42.494
−20.969
1.00
18.44
O


ATOM
15608
N
LYS
B
482
−52.662
−41.252
−22.279
1.00
18.80
N


ATOM
15609
CA
LYS
B
482
−51.727
−41.019
−21.192
1.00
19.58
C


ATOM
15611
CB
LYS
B
482
−50.425
−40.424
−21.727
1.00
20.03
C


ATOM
15614
CG
LYS
B
482
−49.499
−41.500
−22.277
1.00
22.03
C


ATOM
15617
CD
LYS
B
482
−48.706
−41.063
−23.506
1.00
24.87
C


ATOM
15620
CE
LYS
B
482
−47.908
−42.268
−24.066
1.00
26.65
C


ATOM
15623
NZ
LYS
B
482
−47.287
−41.996
−25.408
1.00
28.80
N


ATOM
15627
C
LYS
B
482
−52.363
−40.156
−20.096
1.00
19.56
C


ATOM
15628
O
LYS
B
482
−52.367
−40.537
−18.926
1.00
19.19
O


ATOM
15630
N
MET
B
483
−52.922
−39.013
−20.483
1.00
20.00
N


ATOM
15631
CA
MET
B
483
−53.677
−38.165
−19.552
1.00
20.37
C


ATOM
15633
CB
MET
B
483
−54.426
−37.057
−20.295
1.00
20.25
C


ATOM
15636
CG
MET
B
483
−53.529
−35.951
−20.807
1.00
20.52
C


ATOM
15639
SD
MET
B
483
−54.461
−34.483
−21.225
1.00
20.47
S


ATOM
15640
CE
MET
B
483
−55.361
−35.084
−22.649
1.00
22.07
C


ATOM
15644
C
MET
B
483
−54.668
−38.981
−18.741
1.00
20.72
C


ATOM
15645
O
MET
B
483
−54.809
−38.779
−17.543
1.00
20.37
O


ATOM
15647
N
ASN
B
484
−55.345
−39.910
−19.403
1.00
21.57
N


ATOM
15648
CA
ASN
B
484
−56.339
−40.731
−18.744
1.00
22.46
C


ATOM
15650
CB
ASN
B
484
−57.042
−41.631
−19.765
1.00
22.23
C


ATOM
15653
CG
ASN
B
484
−58.118
−40.900
−20.576
1.00
21.61
C


ATOM
15654
OD1
ASN
B
484
−58.412
−39.722
−20.362
1.00
20.25
O


ATOM
15655
ND2
ASN
B
484
−58.720
−41.622
−21.510
1.00
20.80
N


ATOM
15658
C
ASN
B
484
−55.723
−41.555
−17.598
1.00
23.83
C


ATOM
15659
O
ASN
B
484
−56.262
−41.591
−16.484
1.00
23.76
O


ATOM
15661
N
LYS
B
485
−54.585
−42.190
−17.868
1.00
25.69
N


ATOM
15662
CA
LYS
B
485
−53.854
−42.937
−16.843
1.00
27.11
C


ATOM
15664
CB
LYS
B
485
−52.679
−43.712
−17.447
1.00
27.13
C


ATOM
15667
CG
LYS
B
485
−52.073
−44.755
−16.489
1.00
28.85
C


ATOM
15670
CD
LYS
B
485
−51.643
−46.082
−17.187
1.00
31.17
C


ATOM
15673
CE
LYS
B
485
−50.150
−46.132
−17.555
1.00
32.11
C


ATOM
15676
NZ
LYS
B
485
−49.291
−46.282
−16.344
1.00
33.08
N


ATOM
15680
C
LYS
B
485
−53.370
−42.035
−15.701
1.00
28.37
C


ATOM
15681
O
LYS
B
485
−53.288
−42.481
−14.563
1.00
28.59
O


ATOM
15683
N
GLU
B
486
−53.083
−40.766
−15.980
1.00
29.89
N


ATOM
15684
CA
GLU
B
486
−52.683
−39.849
−14.910
1.00
31.09
C


ATOM
15686
CB
GLU
B
486
−52.174
−38.511
−15.470
1.00
31.55
C


ATOM
15689
CG
GLU
B
486
−51.059
−37.851
−14.643
1.00
32.69
C


ATOM
15692
CD
GLU
B
486
−49.785
−38.689
−14.605
1.00
34.51
C


ATOM
15693
OE1
GLU
B
486
−49.104
−38.682
−13.557
1.00
36.35
O


ATOM
15694
OE2
GLU
B
486
−49.476
−39.368
−15.611
1.00
34.55
O


ATOM
15695
C
GLU
B
486
−53.836
−39.615
−13.939
1.00
31.70
C


ATOM
15696
O
GLU
B
486
−53.684
−39.868
−12.750
1.00
31.90
O


ATOM
15698
N
LYS
B
487
−54.983
−39.164
−14.453
1.00
32.71
N


ATOM
15699
CA
LYS
B
487
−56.177
−38.856
−13.629
1.00
33.57
C


ATOM
15701
CB
LYS
B
487
−57.343
−38.402
−14.519
1.00
33.54
C


ATOM
15704
CG
LYS
B
487
−58.703
−38.196
−13.823
1.00
33.45
C


ATOM
15707
CD
LYS
B
487
−58.686
−37.024
−12.866
1.00
33.71
C


ATOM
15710
CE
LYS
B
487
−59.906
−36.996
−11.931
1.00
34.48
C


ATOM
15713
NZ
LYS
B
487
−61.123
−36.378
−12.526
1.00
35.03
N


ATOM
15717
C
LYS
B
487
−56.626
−40.046
−12.802
1.00
34.60
C


ATOM
15718
O
LYS
B
487
−57.126
−39.892
−11.681
1.00
34.55
O


ATOM
15720
N
LEU
B
488
−56.453
−41.233
−13.371
1.00
35.94
N


ATOM
15721
CA
LEU
B
488
−56.878
−42.451
−12.723
1.00
37.00
C


ATOM
15723
CB
LEU
B
488
−57.280
−43.489
−13.778
1.00
36.90
C


ATOM
15726
CG
LEU
B
488
−58.081
−44.714
−13.312
1.00
37.52
C


ATOM
15728
CD1
LEU
B
488
−58.758
−44.536
−11.946
1.00
38.76
C


ATOM
15732
CD2
LEU
B
488
−59.121
−45.084
−14.346
1.00
38.42
C


ATOM
15736
C
LEU
B
488
−55.786
−42.980
−11.803
1.00
38.02
C


ATOM
15737
O
LEU
B
488
−56.063
−43.315
−10.653
1.00
38.19
O


ATOM
15739
N
GLY
B
489
−54.550
−43.016
−12.298
1.00
39.44
N


ATOM
15740
CA
GLY
B
489
−53.441
−43.710
−11.621
1.00
40.62
C


ATOM
15743
C
GLY
B
489
−52.563
−42.837
−10.740
1.00
41.76
C


ATOM
15744
O
GLY
B
489
−51.357
−42.703
−10.988
1.00
41.83
O


ATOM
15746
N
GLY
B
490
−53.183
−42.230
−9.726
1.00
43.10
N


ATOM
15747
CA
GLY
B
490
−52.481
−41.538
−8.636
1.00
43.82
C


ATOM
15750
C
GLY
B
490
−51.131
−40.924
−8.967
1.00
44.31
C


ATOM
15751
O
GLY
B
490
−50.084
−41.560
−8.831
1.00
44.25
O


ATOM
15753
N
SER
B
491
−51.161
−39.672
−9.396
1.00
44.87
N


ATOM
15754
CA
SER
B
491
−49.939
−38.892
−9.575
1.00
45.22
C


ATOM
15756
CB
SER
B
491
−50.224
−37.723
−10.537
1.00
45.34
C


ATOM
15759
OG
SER
B
491
−51.411
−37.032
−10.166
1.00
45.38
O


ATOM
15761
C
SER
B
491
−49.419
−38.389
−8.203
1.00
45.14
C


ATOM
15762
O
SER
B
491
−49.896
−38.824
−7.140
1.00
45.11
O


ATOM
15764
N
LEU
B
492
−48.429
−37.491
−8.227
1.00
44.77
N


ATOM
15765
CA
LEU
B
492
−48.046
−36.752
−7.018
1.00
44.31
C


ATOM
15767
CB
LEU
B
492
−46.726
−35.971
−7.188
1.00
44.55
C


ATOM
15770
CG
LEU
B
492
−45.530
−36.546
−7.972
1.00
45.73
C


ATOM
15772
CD1
LEU
B
492
−44.373
−35.556
−7.859
1.00
46.25
C


ATOM
15776
CD2
LEU
B
492
−45.084
−37.972
−7.530
1.00
46.14
C


ATOM
15780
C
LEU
B
492
−49.151
−35.760
−6.703
1.00
43.30
C


ATOM
15781
O
LEU
B
492
−49.315
−35.370
−5.555
1.00
43.49
O


ATOM
15783
N
PHE
B
493
−49.903
−35.367
−7.735
1.00
42.05
N


ATOM
15784
CA
PHE
B
493
−50.822
−34.239
−7.668
1.00
41.03
C


ATOM
15786
CB
PHE
B
493
−50.913
−33.549
−9.028
1.00
40.81
C


ATOM
15789
CG
PHE
B
493
−49.696
−32.771
−9.408
1.00
38.96
C


ATOM
15790
CD1
PHE
B
493
−49.651
−31.408
−9.233
1.00
37.06
C


ATOM
15792
CE1
PHE
B
493
−48.543
−30.697
−9.603
1.00
36.41
C


ATOM
15794
CZ
PHE
B
493
−47.471
−31.341
−10.158
1.00
35.87
C


ATOM
15796
CE2
PHE
B
493
−47.507
−32.690
−10.343
1.00
36.39
C


ATOM
15798
CD2
PHE
B
493
−48.612
−33.400
−9.977
1.00
37.36
C


ATOM
15800
C
PHE
B
493
−52.240
−34.603
−7.268
1.00
40.76
C


ATOM
15801
O
PHE
B
493
−52.686
−35.733
−7.419
1.00
40.35
O


ATOM
15803
N
ALA
B
494
−52.943
−33.584
−6.790
1.00
40.72
N


ATOM
15804
CA
ALA
B
494
−54.355
−33.658
−6.471
1.00
40.68
C


ATOM
15806
CB
ALA
B
494
−54.786
−32.362
−5.770
1.00
40.70
C


ATOM
15810
C
ALA
B
494
−55.175
−33.851
−7.744
1.00
40.59
C


ATOM
15811
O
ALA
B
494
−55.013
−33.099
−8.716
1.00
40.95
O


ATOM
15813
N
LYS
B
495
−56.071
−34.835
−7.733
1.00
40.12
N


ATOM
15814
CA
LYS
B
495
−57.000
−35.047
−8.854
1.00
39.67
C


ATOM
15816
CB
LYS
B
495
−58.008
−36.166
−8.520
1.00
39.98
C


ATOM
15819
CG
LYS
B
495
−57.388
−37.590
−8.496
1.00
40.57
C


ATOM
15822
CD
LYS
B
495
−58.468
−38.688
−8.419
1.00
41.18
C


ATOM
15825
CE
LYS
B
495
−57.878
−40.065
−8.132
1.00
41.28
C


ATOM
15828
NZ
LYS
B
495
−58.736
−41.159
−8.671
1.00
41.39
N


ATOM
15832
C
LYS
B
495
−57.717
−33.752
−9.333
1.00
38.82
C


ATOM
15833
O
LYS
B
495
−57.847
−33.535
−10.537
1.00
38.70
O


ATOM
15835
N
PRO
B
496
−58.169
−32.890
−8.397
1.00
37.71
N


ATOM
15836
CA
PRO
B
496
−58.701
−31.551
−8.687
1.00
36.80
C


ATOM
15838
CB
PRO
B
496
−58.820
−30.937
−7.304
1.00
36.94
C


ATOM
15841
CG
PRO
B
496
−59.255
−32.073
−6.483
1.00
37.90
C


ATOM
15844
CD
PRO
B
496
−58.534
−33.294
−7.030
1.00
37.86
C


ATOM
15847
C
PRO
B
496
−57.845
−30.625
−9.536
1.00
35.57
C


ATOM
15848
O
PRO
B
496
−58.389
−29.693
−10.139
1.00
35.93
O


ATOM
15849
N
PHE
B
497
−56.527
−30.836
−9.546
1.00
33.52
N


ATOM
15850
CA
PHE
B
497
−55.654
−30.083
−10.439
1.00
31.34
C


ATOM
15852
CB
PHE
B
497
−54.355
−29.710
−9.750
1.00
30.86
C


ATOM
15855
CG
PHE
B
497
−53.394
−28.989
−10.634
1.00
29.04
C


ATOM
15856
CD1
PHE
B
497
−53.639
−27.700
−11.022
1.00
27.89
C


ATOM
15858
CE1
PHE
B
497
−52.752
−27.028
−11.834
1.00
27.39
C


ATOM
15860
CZ
PHE
B
497
−51.599
−27.653
−12.259
1.00
27.40
C


ATOM
15862
CE2
PHE
B
497
−51.341
−28.941
−11.877
1.00
27.44
C


ATOM
15864
CD2
PHE
B
497
−52.236
−29.604
−11.074
1.00
28.18
C


ATOM
15866
C
PHE
B
497
−55.390
−30.870
−11.714
1.00
30.24
C


ATOM
15867
O
PHE
B
497
−55.301
−30.266
−12.786
1.00
30.39
O


ATOM
15869
N
VAL
B
498
−55.295
−32.200
−11.630
1.00
28.50
N


ATOM
15870
CA
VAL
B
498
−55.076
−32.983
−12.854
1.00
27.54
C


ATOM
15872
CB
VAL
B
498
−54.778
−34.472
−12.611
1.00
27.34
C


ATOM
15874
CG1
VAL
B
498
−56.027
−35.194
−12.262
1.00
28.14
C


ATOM
15878
CG2
VAL
B
498
−53.731
−34.649
−11.530
1.00
27.04
C


ATOM
15882
C
VAL
B
498
−56.277
−32.857
−13.784
1.00
26.60
C


ATOM
15883
O
VAL
B
498
−56.129
−32.864
−14.995
1.00
26.33
O


ATOM
15885
N
GLU
B
499
−57.468
−32.731
−13.214
1.00
25.87
N


ATOM
15886
CA
GLU
B
499
−58.662
−32.484
−14.022
1.00
25.20
C


ATOM
15888
CB
GLU
B
499
−59.975
−32.639
−13.206
1.00
25.26
C


ATOM
15891
CG
GLU
B
499
−61.287
−32.694
−14.028
1.00
25.16
C


ATOM
15894
CD
GLU
B
499
−61.422
−33.922
−14.973
1.00
26.79
C


ATOM
15895
OE1
GLU
B
499
−60.607
−34.880
−14.928
1.00
26.39
O


ATOM
15896
OE2
GLU
B
499
−62.379
−33.926
−15.785
1.00
27.83
O


ATOM
15897
C
GLU
B
499
−58.542
−31.097
−14.641
1.00
24.27
C


ATOM
15898
O
GLU
B
499
−58.819
−30.948
−15.832
1.00
24.32
O


ATOM
15900
N
THR
B
500
−58.098
−30.093
−13.882
1.00
22.90
N


ATOM
15901
CA
THR
B
500
−58.027
−28.764
−14.487
1.00
22.29
C


ATOM
15903
CB
THR
B
500
−57.908
−27.592
−13.488
1.00
22.43
C


ATOM
15905
OG1
THR
B
500
−56.536
−27.259
−13.274
1.00
22.65
O


ATOM
15907
CG2
THR
B
500
−58.614
−27.899
−12.183
1.00
22.84
C


ATOM
15911
C
THR
B
500
−56.940
−28.671
−15.565
1.00
21.20
C


ATOM
15912
O
THR
B
500
−57.120
−27.939
−16.536
1.00
21.06
O


ATOM
15914
N
ALA
B
501
−55.845
−29.414
−15.422
1.00
19.88
N


ATOM
15915
CA
ALA
B
501
−54.906
−29.574
−16.537
1.00
19.24
C


ATOM
15917
CB
ALA
B
501
−53.704
−30.393
−16.115
1.00
19.22
C


ATOM
15921
C
ALA
B
501
−55.581
−30.226
−17.757
1.00
18.68
C


ATOM
15922
O
ALA
B
501
−55.427
−29.768
−18.881
1.00
18.32
O


ATOM
15924
N
ILE
B
502
−56.324
−31.300
−17.523
1.00
18.11
N


ATOM
15925
CA
ILE
B
502
−57.023
−31.988
−18.591
1.00
17.68
C


ATOM
15927
CB
ILE
B
502
−57.750
−33.251
−18.059
1.00
17.63
C


ATOM
15929
CG1
ILE
B
502
−56.713
−34.350
−17.769
1.00
18.16
C


ATOM
15932
CD1
ILE
B
502
−57.253
−35.645
−17.115
1.00
17.02
C


ATOM
15936
CG2
ILE
B
502
−58.756
−33.762
−19.063
1.00
16.93
C


ATOM
15940
C
ILE
B
502
−57.990
−31.030
−19.289
1.00
17.50
C


ATOM
15941
O
ILE
B
502
−58.153
−31.071
−20.512
1.00
17.62
O


ATOM
15943
N
ASN
B
503
−58.604
−30.139
−18.524
1.00
17.23
N


ATOM
15944
CA
ASN
B
503
−59.545
−29.184
−19.102
1.00
17.07
C


ATOM
15946
CB
ASN
B
503
−60.184
−28.327
−18.016
1.00
17.21
C


ATOM
15949
CG
ASN
B
503
−61.155
−29.094
−17.176
1.00
17.29
C


ATOM
15950
OD1
ASN
B
503
−61.721
−30.097
−17.609
1.00
16.66
O


ATOM
15951
ND2
ASN
B
503
−61.365
−28.621
−15.958
1.00
19.16
N


ATOM
15954
C
ASN
B
503
−58.920
−28.270
−20.149
1.00
16.59
C


ATOM
15955
O
ASN
B
503
−59.611
−27.811
−21.071
1.00
16.67
O


ATOM
15957
N
LEU
B
504
−57.629
−27.992
−20.014
1.00
15.79
N


ATOM
15958
CA
LEU
B
504
−56.948
−27.204
−21.031
1.00
15.44
C


ATOM
15960
CB
LEU
B
504
−55.530
−26.865
−20.609
1.00
15.07
C


ATOM
15963
CG
LEU
B
504
−54.933
−25.837
−21.552
1.00
14.21
C


ATOM
15965
CD1
LEU
B
504
−54.246
−24.726
−20.800
1.00
14.21
C


ATOM
15969
CD2
LEU
B
504
−54.000
−26.538
−22.462
1.00
14.27
C


ATOM
15973
C
LEU
B
504
−56.954
−27.933
−22.375
1.00
15.59
C


ATOM
15974
O
LEU
B
504
−57.177
−27.323
−23.414
1.00
15.30
O


ATOM
15976
N
ALA
B
505
−56.732
−29.242
−22.341
1.00
15.89
N


ATOM
15977
CA
ALA
B
505
−56.914
−30.073
−23.514
1.00
16.23
C


ATOM
15979
CB
ALA
B
505
−56.608
−31.483
−23.188
1.00
16.05
C


ATOM
15983
C
ALA
B
505
−58.352
−29.955
−24.010
1.00
16.69
C


ATOM
15984
O
ALA
B
505
−58.598
−29.738
−25.204
1.00
16.88
O


ATOM
15986
N
ARG
B
506
−59.300
−30.071
−23.090
1.00
16.88
N


ATOM
15987
CA
ARG
B
506
−60.709
−29.972
−23.457
1.00
17.20
C


ATOM
15989
CB
ARG
B
506
−61.630
−30.170
−22.248
1.00
17.34
C


ATOM
15992
CG
ARG
B
506
−61.549
−31.537
−21.614
1.00
17.46
C


ATOM
15995
CD
ARG
B
506
−62.837
−31.917
−20.962
1.00
17.48
C


ATOM
15998
NE
ARG
B
506
−62.783
−33.280
−20.435
1.00
18.37
N


ATOM
16000
CZ
ARG
B
506
−62.404
−33.613
−19.201
1.00
19.03
C


ATOM
16001
NH1
ARG
B
506
−62.008
−32.690
−18.324
1.00
18.83
N


ATOM
16004
NH2
ARG
B
506
−62.415
−34.892
−18.841
1.00
19.72
N


ATOM
16007
C
ARG
B
506
−61.038
−28.646
−24.114
1.00
17.32
C


ATOM
16008
O
ARG
B
506
−61.754
−28.622
−25.111
1.00
17.41
O


ATOM
16010
N
GLN
B
507
−60.540
−27.543
−23.564
1.00
17.59
N


ATOM
16011
CA
GLN
B
507
−60.864
−26.233
−24.139
1.00
18.05
C


ATOM
16013
CB
GLN
B
507
−60.382
−25.090
−23.258
1.00
18.16
C


ATOM
16016
CG
GLN
B
507
−60.798
−23.709
−23.764
1.00
17.57
C


ATOM
16019
CD
GLN
B
507
−62.291
−23.508
−23.723
1.00
17.42
C


ATOM
16020
OE1
GLN
B
507
−62.953
−23.959
−22.800
1.00
17.55
O


ATOM
16021
NE2
GLN
B
507
−62.832
−22.823
−24.722
1.00
17.56
N


ATOM
16024
C
GLN
B
507
−60.258
−26.060
−25.521
1.00
18.49
C


ATOM
16025
O
GLN
B
507
−60.855
−25.413
−26.380
1.00
18.73
O


ATOM
16027
N
SER
B
508
−59.066
−26.619
−25.724
1.00
18.85
N


ATOM
16028
CA
SER
B
508
−58.427
−26.621
−27.037
1.00
19.07
C


ATOM
16030
CB
SER
B
508
−57.108
−27.364
−26.969
1.00
19.04
C


ATOM
16033
OG
SER
B
508
−56.304
−26.772
−25.979
1.00
20.10
O


ATOM
16035
C
SER
B
508
−59.305
−27.296
−28.065
1.00
19.12
C


ATOM
16036
O
SER
B
508
−59.438
−26.827
−29.187
1.00
19.00
O


ATOM
16038
N
HIS
B
509
−59.905
−28.409
−27.674
1.00
19.26
N


ATOM
16039
CA
HIS
B
509
−60.814
−29.095
−28.559
1.00
19.33
C


ATOM
16041
CB
HIS
B
509
−61.275
−30.412
−27.959
1.00
19.30
C


ATOM
16044
CG
HIS
B
509
−60.263
−31.501
−28.067
1.00
18.71
C


ATOM
16045
ND1
HIS
B
509
−59.941
−32.089
−29.267
1.00
18.57
N


ATOM
16047
CE1
HIS
B
509
−59.020
−33.012
−29.064
1.00
19.07
C


ATOM
16049
NE2
HIS
B
509
−58.738
−33.044
−27.774
1.00
18.52
N


ATOM
16051
CD2
HIS
B
509
−59.499
−32.105
−27.129
1.00
18.43
C


ATOM
16053
C
HIS
B
509
−62.017
−28.251
−28.878
1.00
19.60
C


ATOM
16054
O
HIS
B
509
−62.491
−28.286
−29.969
1.00
19.68
O


ATOM
16056
N
CYS
B
510
−62.540
−27.502
−27.932
1.00
20.12
N


ATOM
16057
CA
CYS
B
510
−63.748
−26.738
−28.216
1.00
20.63
C


ATOM
16059
CB
CYS
B
510
−64.493
−26.492
−26.915
1.00
20.70
C


ATOM
16062
SG
CYS
B
510
−64.856
−28.020
−26.065
1.00
22.93
S


ATOM
16064
C
CYS
B
510
−63.465
−25.422
−28.950
1.00
20.55
C


ATOM
16065
O
CYS
B
510
−64.338
−24.881
−29.622
1.00
20.16
O


ATOM
16067
N
THR
B
511
−62.236
−24.933
−28.827
1.00
20.89
N


ATOM
16068
CA
THR
B
511
−61.833
−23.654
−29.378
1.00
21.32
C


ATOM
16070
CB
THR
B
511
−60.682
−23.107
−28.550
1.00
20.76
C


ATOM
16072
OG1
THR
B
511
−61.208
−22.619
−27.324
1.00
19.50
O


ATOM
16074
CG2
THR
B
511
−59.961
−21.994
−29.253
1.00
19.79
C


ATOM
16078
C
THR
B
511
−61.417
−23.735
−30.851
1.00
23.11
C


ATOM
16079
O
THR
B
511
−61.910
−22.992
−31.694
1.00
22.75
O


ATOM
16081
N
TYR
B
512
−60.501
−24.646
−31.152
1.00
25.46
N


ATOM
16082
CA
TYR
B
512
−59.867
−24.704
−32.462
1.00
27.09
C


ATOM
16084
CB
TYR
B
512
−58.397
−25.107
−32.327
1.00
27.16
C


ATOM
16087
CG
TYR
B
512
−57.598
−24.056
−31.582
1.00
27.26
C


ATOM
16088
CD1
TYR
B
512
−57.300
−22.834
−32.182
1.00
28.18
C


ATOM
16090
CE1
TYR
B
512
−56.583
−21.844
−31.511
1.00
27.98
C


ATOM
16092
CZ
TYR
B
512
−56.164
−22.068
−30.226
1.00
27.72
C


ATOM
16093
OH
TYR
B
512
−55.462
−21.072
−29.584
1.00
27.09
O


ATOM
16095
CE2
TYR
B
512
−56.453
−23.281
−29.602
1.00
27.52
C


ATOM
16097
CD2
TYR
B
512
−57.171
−24.262
−30.278
1.00
26.68
C


ATOM
16099
C
TYR
B
512
−60.633
−25.623
−33.382
1.00
28.79
C


ATOM
16100
O
TYR
B
512
−61.050
−25.179
−34.444
1.00
28.98
O


ATOM
16102
N
HIS
B
513
−60.789
−26.893
−32.991
1.00
31.06
N


ATOM
16103
CA
HIS
B
513
−61.865
−27.800
−33.492
1.00
33.07
C


ATOM
16105
CB
HIS
B
513
−62.740
−28.208
−32.265
1.00
33.66
C


ATOM
16108
CG
HIS
B
513
−64.181
−28.602
−32.535
1.00
34.73
C


ATOM
16109
ND1
HIS
B
513
−65.035
−27.903
−33.367
1.00
35.70
N


ATOM
16111
CE1
HIS
B
513
−66.234
−28.464
−33.343
1.00
35.40
C


ATOM
16113
NE2
HIS
B
513
−66.206
−29.469
−32.491
1.00
35.10
N


ATOM
16115
CD2
HIS
B
513
−64.943
−29.565
−31.956
1.00
35.07
C


ATOM
16117
C
HIS
B
513
−62.692
−27.179
−34.623
1.00
34.03
C


ATOM
16118
O
HIS
B
513
−63.003
−27.848
−35.627
1.00
34.55
O


ATOM
16120
N
ASN
B
514
−63.047
−25.906
−34.444
1.00
34.65
N


ATOM
16121
CA
ASN
B
514
−63.713
−25.123
−35.483
1.00
35.15
C


ATOM
16123
CB
ASN
B
514
−63.845
−23.643
−35.070
1.00
35.01
C


ATOM
16126
CG
ASN
B
514
−64.704
−23.456
−33.820
1.00
33.48
C


ATOM
16127
OD1
ASN
B
514
−64.787
−24.343
−32.968
1.00
30.92
O


ATOM
16128
ND2
ASN
B
514
−65.327
−22.295
−33.703
1.00
32.16
N


ATOM
16131
C
ASN
B
514
−63.192
−25.274
−36.942
1.00
36.08
C


ATOM
16132
O
ASN
B
514
−62.010
−25.051
−37.254
1.00
35.69
O


ATOM
16134
N
GLY
B
515
−64.119
−25.765
−37.772
1.00
37.15
N


ATOM
16135
CA
GLY
B
515
−64.224
−25.493
−39.177
1.00
37.94
C


ATOM
16138
C
GLY
B
515
−65.269
−24.384
−39.284
1.00
39.01
C


ATOM
16139
O
GLY
B
515
−64.904
−23.286
−39.702
1.00
39.58
O


ATOM
16141
N
ASP
B
516
−66.550
−24.585
−38.909
1.00
39.95
N


ATOM
16142
CA
ASP
B
516
−67.167
−25.810
−38.349
1.00
40.65
C


ATOM
16144
CB
ASP
B
516
−67.296
−25.652
−36.836
1.00
41.09
C


ATOM
16147
CG
ASP
B
516
−66.318
−26.511
−36.063
1.00
43.63
C


ATOM
16148
OD1
ASP
B
516
−65.697
−27.434
−36.662
1.00
45.83
O


ATOM
16149
OD2
ASP
B
516
−66.152
−26.246
−34.843
1.00
47.12
O


ATOM
16150
C
ASP
B
516
−68.603
−26.067
−38.853
1.00
40.78
C


ATOM
16151
O
ASP
B
516
−69.134
−25.301
−39.660
1.00
41.28
O


ATOM
16153
N
ALA
B
517
−69.222
−27.141
−38.349
1.00
40.66
N


ATOM
16154
CA
ALA
B
517
−70.675
−27.396
−38.468
1.00
40.60
C


ATOM
16156
CB
ALA
B
517
−71.422
−26.622
−37.359
1.00
40.27
C


ATOM
16160
C
ALA
B
517
−71.295
−27.106
−39.862
1.00
40.79
C


ATOM
16161
O
ALA
B
517
−70.654
−27.296
−40.899
1.00
40.67
O


ATOM
16163
N
HIS
B
518
−72.562
−26.696
−39.874
1.00
41.13
N


ATOM
16164
CA
HIS
B
518
−73.162
−26.033
−41.039
1.00
41.60
C


ATOM
16166
CB
HIS
B
518
−74.446
−26.756
−41.480
1.00
42.24
C


ATOM
16169
CG
HIS
B
518
−74.207
−28.179
−41.910
1.00
45.54
C


ATOM
16170
ND1
HIS
B
518
−73.441
−28.509
−43.012
1.00
48.51
N


ATOM
16172
CE1
HIS
B
518
−73.392
−29.825
−43.140
1.00
48.79
C


ATOM
16174
NE2
HIS
B
518
−74.092
−30.364
−42.156
1.00
49.12
N


ATOM
16176
CD2
HIS
B
518
−74.608
−29.357
−41.369
1.00
48.28
C


ATOM
16178
C
HIS
B
518
−73.377
−24.545
−40.686
1.00
40.84
C


ATOM
16179
O
HIS
B
518
−74.487
−23.997
−40.769
1.00
40.60
O


ATOM
16181
N
THR
B
519
−72.261
−23.932
−40.275
1.00
40.10
N


ATOM
16182
CA
THR
B
519
−72.143
−22.521
−39.878
1.00
39.39
C


ATOM
16184
CB
THR
B
519
−72.561
−22.263
−38.393
1.00
39.40
C


ATOM
16186
OG1
THR
B
519
−71.823
−23.131
−37.517
1.00
39.55
O


ATOM
16188
CG2
THR
B
519
−74.074
−22.460
−38.178
1.00
38.98
C


ATOM
16192
C
THR
B
519
−70.654
−22.164
−40.059
1.00
38.81
C


ATOM
16193
O
THR
B
519
−69.800
−23.050
−40.067
1.00
38.48
O


ATOM
16195
N
SER
B
520
−70.338
−20.881
−40.199
1.00
38.19
N


ATOM
16196
CA
SER
B
520
−68.959
−20.453
−40.521
1.00
37.77
C


ATOM
16198
CB
SER
B
520
−68.983
−18.976
−40.960
1.00
37.76
C


ATOM
16201
OG
SER
B
520
−68.760
−18.106
−39.870
1.00
38.49
O


ATOM
16203
C
SER
B
520
−67.974
−20.724
−39.340
1.00
37.24
C


ATOM
16204
O
SER
B
520
−68.394
−21.267
−38.320
1.00
36.89
O


ATOM
16206
N
PRO
B
521
−66.671
−20.350
−39.472
1.00
36.96
N


ATOM
16207
CA
PRO
B
521
−65.692
−20.638
−38.396
1.00
36.80
C


ATOM
16209
CB
PRO
B
521
−64.320
−20.354
−39.041
1.00
36.68
C


ATOM
16212
CG
PRO
B
521
−64.599
−19.593
−40.309
1.00
37.19
C


ATOM
16215
CD
PRO
B
521
−66.091
−19.469
−40.507
1.00
37.10
C


ATOM
16218
C
PRO
B
521
−65.915
−19.763
−37.168
1.00
36.68
C


ATOM
16219
O
PRO
B
521
−66.233
−20.289
−36.105
1.00
36.90
O


ATOM
16220
N
ASP
B
522
−65.744
−18.445
−37.298
1.00
36.61
N


ATOM
16221
CA
ASP
B
522
−66.373
−17.528
−36.347
1.00
36.58
C


ATOM
16223
CB
ASP
B
522
−65.938
−16.070
−36.543
1.00
36.82
C


ATOM
16226
CG
ASP
B
522
−64.456
−15.846
−36.243
1.00
37.94
C


ATOM
16227
OD1
ASP
B
522
−63.848
−16.627
−35.473
1.00
39.62
O


ATOM
16228
OD2
ASP
B
522
−63.891
−14.876
−36.790
1.00
39.40
O


ATOM
16229
C
ASP
B
522
−67.836
−17.718
−36.681
1.00
36.12
C


ATOM
16230
O
ASP
B
522
−68.150
−18.306
−37.702
1.00
35.98
O


ATOM
16232
N
GLU
B
523
−68.732
−17.249
−35.830
1.00
35.69
N


ATOM
16233
CA
GLU
B
523
−70.152
−17.605
−35.927
1.00
35.46
C


ATOM
16235
CB
GLU
B
523
−70.703
−17.560
−37.379
1.00
35.51
C


ATOM
16238
CG
GLU
B
523
−70.535
−16.175
−38.061
1.00
36.11
C


ATOM
16241
CD
GLU
B
523
−70.854
−16.136
−39.572
1.00
36.72
C


ATOM
16242
OE1
GLU
B
523
−71.848
−16.767
−40.013
1.00
37.20
O


ATOM
16243
OE2
GLU
B
523
−70.101
−15.452
−40.314
1.00
35.53
O


ATOM
16244
C
GLU
B
523
−70.440
−18.943
−35.216
1.00
34.97
C


ATOM
16245
O
GLU
B
523
−71.557
−19.148
−34.765
1.00
35.02
O


ATOM
16247
N
LEU
B
524
−69.462
−19.846
−35.099
1.00
34.59
N


ATOM
16248
CA
LEU
B
524
−69.503
−20.832
−34.004
1.00
34.45
C


ATOM
16250
CB
LEU
B
524
−68.735
−22.136
−34.286
1.00
34.21
C


ATOM
16253
CG
LEU
B
524
−69.530
−23.434
−34.508
1.00
33.92
C


ATOM
16255
CD1
LEU
B
524
−68.657
−24.627
−34.227
1.00
32.21
C


ATOM
16259
CD2
LEU
B
524
−70.794
−23.520
−33.641
1.00
34.06
C


ATOM
16263
C
LEU
B
524
−68.901
−20.162
−32.791
1.00
34.38
C


ATOM
16264
O
LEU
B
524
−69.535
−20.067
−31.741
1.00
34.49
O


ATOM
16266
N
THR
B
525
−67.670
−19.688
−32.958
1.00
34.30
N


ATOM
16267
CA
THR
B
525
−66.913
−19.073
−31.874
1.00
34.23
C


ATOM
16269
CB
THR
B
525
−65.570
−18.524
−32.380
1.00
34.04
C


ATOM
16271
OG1
THR
B
525
−64.894
−19.549
−33.112
1.00
33.83
O


ATOM
16273
CG2
THR
B
525
−64.689
−18.087
−31.227
1.00
33.37
C


ATOM
16277
C
THR
B
525
−67.702
−17.960
−31.184
1.00
34.46
C


ATOM
16278
O
THR
B
525
−67.684
−17.858
−29.955
1.00
34.57
O


ATOM
16280
N
ARG
B
526
−68.401
−17.144
−31.969
1.00
34.54
N


ATOM
16281
CA
ARG
B
526
−69.200
−16.056
−31.418
1.00
34.60
C


ATOM
16283
CB
ARG
B
526
−69.571
−15.059
−32.513
1.00
35.04
C


ATOM
16286
CG
ARG
B
526
−70.256
−13.800
−32.013
1.00
37.13
C


ATOM
16289
CD
ARG
B
526
−70.143
−12.656
−33.026
1.00
39.87
C


ATOM
16292
NE
ARG
B
526
−70.353
−13.075
−34.420
1.00
42.28
N


ATOM
16294
CZ
ARG
B
526
−71.543
−13.292
−35.000
1.00
44.26
C


ATOM
16295
NH1
ARG
B
526
−72.685
−13.159
−34.320
1.00
44.66
N


ATOM
16298
NH2
ARG
B
526
−71.593
−13.658
−36.279
1.00
44.49
N


ATOM
16301
C
ARG
B
526
−70.448
−16.593
−30.735
1.00
33.91
C


ATOM
16302
O
ARG
B
526
−70.848
−16.074
−29.704
1.00
33.74
O


ATOM
16304
N
LYS
B
527
−71.048
−17.637
−31.306
1.00
33.39
N


ATOM
16305
CA
LYS
B
527
−72.240
−18.252
−30.722
1.00
33.15
C


ATOM
16307
CB
LYS
B
527
−72.837
−19.332
−31.639
1.00
33.42
C


ATOM
16310
CG
LYS
B
527
−73.898
−18.804
−32.609
1.00
34.55
C


ATOM
16313
CD
LYS
B
527
−74.643
−19.919
−33.358
1.00
35.43
C


ATOM
16316
CE
LYS
B
527
−75.230
−19.383
−34.667
1.00
36.11
C


ATOM
16319
NZ
LYS
B
527
−76.076
−20.372
−35.384
1.00
37.04
N


ATOM
16323
C
LYS
B
527
−71.925
−18.865
−29.378
1.00
32.36
C


ATOM
16324
O
LYS
B
527
−72.589
−18.584
−28.387
1.00
32.56
O


ATOM
16326
N
ARG
B
528
−70.909
−19.713
−29.358
1.00
31.53
N


ATOM
16327
CA
ARG
B
528
−70.502
−20.401
−28.138
1.00
30.77
C


ATOM
16329
CB
ARG
B
528
−69.283
−21.286
−28.414
1.00
30.55
C


ATOM
16332
CG
ARG
B
528
−69.624
−22.519
−29.252
1.00
29.48
C


ATOM
16335
CD
ARG
B
528
−68.418
−23.417
−29.493
1.00
28.05
C


ATOM
16338
NE
ARG
B
528
−68.811
−24.774
−29.880
1.00
26.55
N


ATOM
16340
CZ
ARG
B
528
−67.968
−25.719
−30.288
1.00
25.87
C


ATOM
16341
NH1
ARG
B
528
−66.668
−25.472
−30.385
1.00
26.33
N


ATOM
16344
NH2
ARG
B
528
−68.424
−26.920
−30.615
1.00
25.49
N


ATOM
16347
C
ARG
B
528
−70.225
−19.415
−27.004
1.00
30.42
C


ATOM
16348
O
ARG
B
528
−70.721
−19.582
−25.885
1.00
30.30
O


ATOM
16350
N
VAL
B
529
−69.455
−18.376
−27.307
1.00
29.96
N


ATOM
16351
CA
VAL
B
529
−69.194
−17.312
−26.342
1.00
29.47
C


ATOM
16353
CB
VAL
B
529
−68.261
−16.227
−26.932
1.00
29.40
C


ATOM
16355
CG1
VAL
B
529
−68.269
−14.968
−26.081
1.00
29.18
C


ATOM
16359
CG2
VAL
B
529
−66.845
−16.782
−27.062
1.00
28.90
C


ATOM
16363
C
VAL
B
529
−70.516
−16.723
−25.841
1.00
28.98
C


ATOM
16364
O
VAL
B
529
−70.759
−16.682
−24.641
1.00
28.97
O


ATOM
16366
N
LEU
B
530
−71.384
−16.308
−26.752
1.00
28.54
N


ATOM
16367
CA
LEU
B
530
−72.709
−15.824
−26.353
1.00
28.23
C


ATOM
16369
CB
LEU
B
530
−73.631
−15.604
−27.559
1.00
28.09
C


ATOM
16372
CG
LEU
B
530
−73.767
−14.150
−28.007
1.00
28.15
C


ATOM
16374
CD1
LEU
B
530
−72.412
−13.570
−28.406
1.00
27.99
C


ATOM
16378
CD2
LEU
B
530
−74.784
−14.034
−29.150
1.00
28.85
C


ATOM
16382
C
LEU
B
530
−73.389
−16.767
−25.367
1.00
27.88
C


ATOM
16383
O
LEU
B
530
−73.932
−16.319
−24.363
1.00
28.11
O


ATOM
16385
N
SER
B
531
−73.352
−18.066
−25.652
1.00
27.28
N


ATOM
16386
CA
SER
B
531
−74.081
−19.049
−24.849
1.00
26.68
C


ATOM
16388
CB
SER
B
531
−74.209
−20.363
−25.612
1.00
26.68
C


ATOM
16391
OG
SER
B
531
−72.970
−21.033
−25.681
1.00
26.67
O


ATOM
16393
C
SER
B
531
−73.410
−19.312
−23.514
1.00
26.20
C


ATOM
16394
O
SER
B
531
−74.076
−19.550
−22.511
1.00
25.86
O


ATOM
16396
N
VAL
B
532
−72.085
−19.281
−23.512
1.00
25.86
N


ATOM
16397
CA
VAL
B
532
−71.320
−19.562
−22.306
1.00
25.51
C


ATOM
16399
CB
VAL
B
532
−69.891
−20.055
−22.651
1.00
25.34
C


ATOM
16401
CG1
VAL
B
532
−68.955
−19.932
−21.460
1.00
24.01
C


ATOM
16405
CG2
VAL
B
532
−69.950
−21.484
−23.158
1.00
24.95
C


ATOM
16409
C
VAL
B
532
−71.271
−18.357
−21.373
1.00
25.52
C


ATOM
16410
O
VAL
B
532
−71.377
−18.523
−20.164
1.00
25.82
O


ATOM
16412
N
ILE
B
533
−71.137
−17.158
−21.935
1.00
25.39
N


ATOM
16413
CA
ILE
B
533
−70.875
−15.954
−21.151
1.00
25.48
C


ATOM
16415
CB
ILE
B
533
−69.666
−15.185
−21.732
1.00
25.30
C


ATOM
16417
CG1
ILE
B
533
−68.375
−15.928
−21.451
1.00
24.91
C


ATOM
16420
CD1
ILE
B
533
−68.118
−16.120
−19.989
1.00
25.00
C


ATOM
16424
CG2
ILE
B
533
−69.553
−13.797
−21.130
1.00
25.81
C


ATOM
16428
C
ILE
B
533
−72.065
−14.983
−21.030
1.00
25.77
C


ATOM
16429
O
ILE
B
533
−72.537
−14.707
−19.928
1.00
25.77
O


ATOM
16431
N
THR
B
534
−72.541
−14.442
−22.142
1.00
25.98
N


ATOM
16432
CA
THR
B
534
−73.446
−13.295
−22.064
1.00
26.31
C


ATOM
16434
CB
THR
B
534
−73.094
−12.253
−23.143
1.00
26.21
C


ATOM
16436
OG1
THR
B
534
−72.914
−12.909
−24.397
1.00
26.72
O


ATOM
16438
CG2
THR
B
534
−71.795
−11.535
−22.781
1.00
25.97
C


ATOM
16442
C
THR
B
534
−74.961
−13.621
−22.064
1.00
26.50
C


ATOM
16443
O
THR
B
534
−75.713
−12.974
−21.344
1.00
26.67
O


ATOM
16445
N
GLU
B
535
−75.410
−14.616
−22.829
1.00
26.55
N


ATOM
16446
CA
GLU
B
535
−76.851
−14.892
−22.961
1.00
26.50
C


ATOM
16448
CB
GLU
B
535
−77.197
−15.197
−24.426
1.00
26.68
C


ATOM
16451
CG
GLU
B
535
−77.226
−13.936
−25.296
1.00
27.68
C


ATOM
16454
CD
GLU
B
535
−78.193
−14.014
−26.475
1.00
28.75
C


ATOM
16455
OE1
GLU
B
535
−79.370
−13.588
−26.330
1.00
27.72
O


ATOM
16456
OE2
GLU
B
535
−77.762
−14.492
−27.549
1.00
30.06
O


ATOM
16457
C
GLU
B
535
−77.355
−16.019
−22.056
1.00
26.19
C


ATOM
16458
O
GLU
B
535
−77.021
−17.171
−22.279
1.00
26.15
O


ATOM
16460
N
PRO
B
536
−78.186
−15.697
−21.047
1.00
26.05
N


ATOM
16461
CA
PRO
B
536
−78.692
−16.763
−20.196
1.00
26.05
C


ATOM
16463
CB
PRO
B
536
−79.495
−16.018
−19.118
1.00
25.87
C


ATOM
16466
CG
PRO
B
536
−79.140
−14.621
−19.239
1.00
25.88
C


ATOM
16469
CD
PRO
B
536
−78.760
−14.402
−20.660
1.00
26.21
C


ATOM
16472
C
PRO
B
536
−79.608
−17.717
−20.943
1.00
26.14
C


ATOM
16473
O
PRO
B
536
−80.173
−17.359
−21.973
1.00
25.99
O


ATOM
16474
N
ILE
B
537
−79.746
−18.924
−20.411
1.00
26.38
N


ATOM
16475
CA
ILE
B
537
−80.662
−19.905
−20.960
1.00
26.58
C


ATOM
16477
CB
ILE
B
537
−80.443
−21.292
−20.333
1.00
26.47
C


ATOM
16479
CG1
ILE
B
537
−79.023
−21.789
−20.600
1.00
26.38
C


ATOM
16482
CD1
ILE
B
537
−78.709
−23.102
−19.907
1.00
26.40
C


ATOM
16486
CG2
ILE
B
537
−81.430
−22.300
−20.890
1.00
26.71
C


ATOM
16490
C
ILE
B
537
−82.072
−19.420
−20.657
1.00
26.93
C


ATOM
16491
O
ILE
B
537
−82.347
−18.965
−19.545
1.00
26.81
O


ATOM
16493
N
LEU
B
538
−82.963
−19.491
−21.641
1.00
27.36
N


ATOM
16494
CA
LEU
B
538
−84.309
−18.984
−21.439
1.00
27.68
C


ATOM
16496
CB
LEU
B
538
−85.181
−19.094
−22.698
1.00
27.75
C


ATOM
16499
CG
LEU
B
538
−84.782
−18.291
−23.949
1.00
27.47
C


ATOM
16501
CD1
LEU
B
538
−85.992
−18.109
−24.844
1.00
27.11
C


ATOM
16505
CD2
LEU
B
538
−84.164
−16.933
−23.621
1.00
26.99
C


ATOM
16509
C
LEU
B
538
−84.919
−19.752
−20.288
1.00
28.01
C


ATOM
16512
N
PRO
B
539
−85.645
−19.046
−19.421
1.00
28.69
N


ATOM
16513
CA
PRO
B
539
−86.028
−19.631
−18.152
1.00
29.05
C


ATOM
16515
CB
PRO
B
539
−86.640
−18.452
−17.397
1.00
29.08
C


ATOM
16518
CG
PRO
B
539
−87.144
−17.548
−18.447
1.00
28.86
C


ATOM
16521
CD
PRO
B
539
−86.298
−17.748
−19.660
1.00
28.62
C


ATOM
16524
C
PRO
B
539
−87.035
−20.767
−18.259
1.00
29.51
C


ATOM
16525
O
PRO
B
539
−87.665
−20.970
−19.297
1.00
29.23
O


ATOM
16526
N
PHE
B
540
−87.164
−21.500
−17.159
1.00
30.25
N


ATOM
16527
CA
PHE
B
540
−88.089
−22.613
−17.070
1.00
30.56
C


ATOM
16529
CB
PHE
B
540
−87.971
−23.297
−15.708
1.00
30.73
C


ATOM
16532
CG
PHE
B
540
−88.848
−24.499
−15.567
1.00
30.49
C


ATOM
16533
CD1
PHE
B
540
−89.910
−24.505
−14.683
1.00
30.32
C


ATOM
16535
CE1
PHE
B
540
−90.718
−25.614
−14.568
1.00
30.59
C


ATOM
16537
CZ
PHE
B
540
−90.475
−26.722
−15.346
1.00
30.55
C


ATOM
16539
CE2
PHE
B
540
−89.420
−26.720
−16.234
1.00
30.68
C


ATOM
16541
CD2
PHE
B
540
−88.619
−25.617
−16.342
1.00
30.43
C


ATOM
16543
C
PHE
B
540
−89.507
−22.120
−17.257
1.00
30.76
C


ATOM
16544
O
PHE
B
540
−89.967
−21.257
−16.508
1.00
30.59
O


ATOM
16546
N
GLU
B
541
−90.184
−22.677
−18.259
1.00
31.13
N


ATOM
16547
CA
GLU
B
541
−91.553
−22.289
−18.608
1.00
31.45
C


ATOM
16549
CB
GLU
B
541
−91.525
−21.186
−19.680
1.00
31.60
C


ATOM
16552
CG
GLU
B
541
−92.860
−20.454
−19.911
1.00
32.56
C


ATOM
16555
CD
GLU
B
541
−93.773
−21.133
−20.935
1.00
33.64
C


ATOM
16556
OE1
GLU
B
541
−93.261
−21.922
−21.771
1.00
35.06
O


ATOM
16557
OE2
GLU
B
541
−95.002
−20.868
−20.901
1.00
32.44
O


ATOM
16558
C
GLU
B
541
−92.326
−23.510
−19.105
1.00
31.31
C


ATOM
16559
O
GLU
B
541
−92.860
−24.286
−18.310
1.00
31.30
O


ATOM
16562
MG
MG
C
1
−42.844
11.427
13.309
1.00
46.29
MG


ATOM
16561
MG
MG
C
2
−46.615
−18.454
−33.231
1.00
48.45
MG


ATOM
16563
O
HOH
E
1
−50.507
−5.408
−4.491
1.00
17.42
O


ATOM
16566
O
HOH
E
2
−64.748
−36.007
−11.725
1.00
2.00
O


ATOM
16569
O
HOH
E
3
−40.643
−2.220
−34.996
1.00
2.00
O


ATOM
16572
O
HOH
E
4
−36.090
−9.757
−37.074
1.00
17.20
O


ATOM
16575
O
HOH
E
5
−46.117
−37.662
−22.916
1.00
17.03
O


ATOM
16578
O
HOH
E
6
−49.541
35.476
6.921
1.00
14.03
O


ATOM
16581
O
HOH
E
7
−32.288
27.572
16.443
1.00
13.16
O


ATOM
16584
O
HOH
E
8
−50.706
10.207
−15.061
1.00
18.73
O


ATOM
16587
O
HOH
E
9
−77.188
36.767
−9.218
1.00
8.05
O


ATOM
16590
O
HOH
E
10
−90.260
−31.248
−21.071
1.00
2.00
O


ATOM
16593
O
HOH
E
11
−70.920
−33.414
−3.884
1.00
9.35
O


ATOM
16596
O
HOH
E
12
−37.761
−21.294
−9.249
1.00
25.78
O


ATOM
16599
O
HOH
E
13
−76.050
23.855
−18.293
1.00
2.00
O


ATOM
16602
O
HOH
E
14
−76.876
−19.575
−22.856
1.00
19.25
O


ATOM
16605
O
HOH
E
15
−40.936
11.629
−24.832
1.00
22.29
O


ATOM
16608
O
HOH
E
16
−85.551
34.832
3.260
1.00
25.14
O


ATOM
16611
O
HOH
E
17
−56.825
31.771
−7.464
1.00
17.27
O


ATOM
16614
O
HOH
E
18
−76.222
39.261
−.613
1.00
25.47
O









Example 4
Three-Dimensional Structure of P. alba IspS
I. Expression of 6×His-Tagged IspS
N-terminally 6×His-tagged IspS was expressed and purified from strain MD09-167. Construction of MD09-167 is described in Example 2. The growth procedure is suitable for histidine tagged enzymes expressed in BL21(λDE3)pLysS cells. A 10 ml of overnight culture was prepared for each 1 L of planned growth. The appropriate antibiotics (50 mg/ml kanamycin, 50 mg/ml chloramphenicol, and/or 50 mg/ml Carbenecillin) was added to 10 ml of LB medium in a 25 ml flask and was inoculated with 1 colony from a fresh plate of cells or directly from glycerol frozen cell stock. Cultures were grown at 30° C. overnight with shaking at  ̃220 rpm. Day cultures were prepared in 1 liter of LB medium with appropriate antibiotics for each culture. Each 1 L day culture was inoculated with 10 ml of overnight culture and grown at 30-37° C. with shaking at  ̃220 rpm until the OD600 reached  ̃0.4-0.6. Day cultures were then induced with 400 μM IPTG and allowed to continue growing at 30° C. with shaking at 220 rpm for  ̃5-6 hours. Cells were then harvested by centrifugation at 10,000×g for 10 min, 4° C. Following Harvest, cells were used directly or stored at −80° C. until ready to process
II. Purification of 6×His-Tagged IspS
For purification of histidine tagged enzymes from BL21(λDE3)pLysS cells, cells were gently resuspended in fresh Lysis buffer (Lysis buffer: Ni wash buffer+0.5 mM PMST, 0.01% Tween-20, 1 mg/ml lysozyme, 0.2 mg/ml DNaseI; Ni wash buffer: 50 mM NaH2PO4, 300 mM NaCl, 20 mM Imidazole, pH 8.0). Approximately 40-50 ml of lysis buffer was used per 1 L of cell pellet. Cells were then incubated on ice for approximately 30 min. The cell suspension was then lysed fully by passing 2-3 times through a french pressure cell (large french press cell at 1200 psi/High setting) until lysate started to look clear. A sample of the lysate was saved for activity assay and gel analysis ( ̃100 μl). The lysate was then clarified by centrifuging the lysate at 30,000×g for 30 min, 4° C. in a Sorvall Discovery 90SE ultracentrifuge. The supernatant was removed and retained. A sample of the “clarified lysate” was saved for activity assay and gel analysis ( ̃100 μl).
The clarified lysate was run over HisTrap HP columns (GE healthcare) using a gradient from 0-100% Ni buffer B. Following loading of the lysate on the column, the column was washed with Ni wash buffer (50 mM NaH2PO4, 300 mm NaCl, 20 mM imidazole, ph 8.0). The his-tagged IspS was then eluted from the column using a gradient from 0-100% Ni elution buffer (50 mM NaH2PO4, 300 mM NaCl, 500 mM imidazole, ph 8.0) and fractions containing the his-tagged IspS were collected. The column was then washed with Ni stripping buffer (20 mM NaH2PO4, 0.5 m NaCl, 50 mM EDTA, ph 7.4). Samples were then analyzed by SDS-PAGE gel (4-12% gel NUPAGE, Invitrogen) according to manufacturer's directions. Desired fractions were concentrated on spin filters (Vivaspin-20, Sartoris,) and then desalted over a Hi Prep 26/10 Desalting column (GE healthcare) packed with Sephadex G25 resin. The G-25 buffer consisted of 50 mM HEPES, 50 mM NaCl, and 1 mM DTT, pH 7.4. The desired sample was then chromatographed on Hi Trap Q HP column (GE) (Q seph buffer A was 50 mM Tris, 0.05 M NaCl, 1 mM DTT, pH 7.6. Q seph buffer B was 50 mM Tris, 1.0 M NaCl, 1 mM DTT, pH 7.6) and concentrated if necessary. Sample buffer was then exchanged by passing sample over a Hi Prep 26/10 Desalting column (GE healthcare) packed with Sephadex G25 resin. A final polishing step of Gel filtration is used as necessary. Pass the sample over a Hi Load 26/60 Superdex 200 prep grade (GE) in gel filtration buffer: (50 mM HEPES, 150 mM NaCl, 1 mM DTT, pH 7.4). Fractions were then analyzed and concentrated. The samples were then stored at −80° C.
TEV Cleavage (IspS from Strains MD09-165 and MD09-167)
For digestion, enzymes were purified through a Ni charged sepharose (GE Healthcare) and desalted into 50 mM HEPES, 50 mM NaCl pH 7.4 buffer containing 1 mM DTT. Digestion was performed with TurboTEV Protease from Eton Bioscience Inc. One unit of TurboTEV per 10 μg of purified protein was used. The digest was performed at 4° C. overnight. Samples were passed through another Ni column equilibrated in the Ni buffer to remove uncleaved enzyme, tag, TurboTEV protease (which is also tagged), and impurities. The Ni column pass though and washes were analyzed using SDS-PAGE gel (NUPAGE, Invitrogen) and DMAPP activity assays. Samples containing pure enzyme were pooled and desalted into 50 mM NaCl pH 7.4 buffer containing 1 mM DTT and stored at −80° C.
III. Crystal Structure Determination
The enzyme expressed from MD09-167 was purified and a concentrated protein solution was then prepared for surveying possible crystallization conditions. The protein was purified independently and surveyed as described below. All in-house crystallization screens were set up using the hanging drop vapor diffusion method. At a minimum, the protein was surveyed using the following commercial screens: the Crystal Screen from Hampton Research (Aliso Viejo, Calif.) and the JCSG+Suite from Qiagen (Valencia, Calif.).
A truncated P. alba IspS construct featuring two additional residues before the twin-arginine motif was generated (MD09-167). This construct contains a C-terminal histidine-tag, and crystallization experiments were set up with the tag either cleaved or not cleaved, at varying protein concentrations, and with or without sodium pyrophosphate. Initial crystallization screens were setup using the Crystal Screen from Hampton Research and the JCSG+Suite from Qiagen. Crystals of protein derived from MD09-167 were observed in numerous conditions; optimization included 528 variations of pH, precipitating agents, concentrations, and inhibitors. From the optimization experiments, twenty different MD09-167 crystals were screened in-house for diffraction. In an effort to improve the resolution, various crystal freezing conditions were tested, with the effect of improving the diffraction limits from 10 Å to 6.5 Å. Upon further optimization of both crystallization and freezing conditions, a crystal composed of non-cleaved histidine-tagged protein was obtained that diffracted to 2.7 Å in house. The large, rod-shaped crystals belong to the tetragonal space group P43212, and have unit cell dimensions a=156.8, b=156.8, c=142.5. The crystals were grown by mixing 2 μL of protein (9 mg/ml protein) with 2 μL of precipitant solution (0.2 M NaMalonate, pH 7.0 and 18% (wt/vol) polyethylene glycol 3350) and equilibrated against 500 μL of precipitant. Prior to flash-freezing the crystal in liquid nitrogen, the crystals were cryoprotected by swishing through 0.2 M NaMalonate, pH 7.0, 18% (wt/vol) polyethylene glycol 3350, and 25% (wt/vol) ethylene glycol.
An identical crystal was prepared and sent to Stanford Synchrotron Radiation Laboratory, and data were collected at Beamline 11-1. Data were integrated using Mosflm (Leslie, A. (1998) J. of Appl. Crystallography 30, 1036-1040) and scaled using SCALA (Collaborative Computational Project, N. (1994) Acta Crystallographica Section D 50, 760-763). The data were phased with MOLREP (Vagin, A., and Teplyakov, A. (1997) J. of Appl. Crystallography 30, 1022-1025), using the IspS from P. tremuloides (Example 3) as the starting model. The crystal contains one dimer in the asymmetric unit with a solvent content of 64%. Data collection and refinement statistics are given in Table 4-1.
Refinement with Refmac5 (Collaborative Computational Project, N. (1994) Acta Crystallographica Section D 50, 760-763) was used with iterative manual rebuilding steps using the visualization program Coot (Emsley, P., and Cowtan, K. (2004) Acta Crystallographica Section D 60, 2126-2132). During refinement, the geometry of the protein was checked using Molprobity (Davis, I. W., et al. (2007) Nucl. Acids Res., 35:W375-W383). The coordinates are provided in Table 4-2.







TABLE 4-1





Data Collection and Refinement Statistics


















Data Collection




Space Group
P43212



Cell dimensions



A, b, c (Å)
156.8, 156.8, 142.5



α, β, γ, (°)
90.0, 90.0, 90.0



Resolution (Å)
45.5-2.30



Rmerge
  8.2 (60.6)a



<I/σI>
10.0 (2.2) 



Completeness (%)
99.1 (96.2)



Redundancy
4.7 (4.3)



Refinement



Resolution (Å)
38.0-2.30



No. measured reflections
366320



No. Unique reflections
74242



Rwork
20.7



Rfree
24.2



rmsd bonds, (Å)
0.012



rmsd angles, (°)
1.206



No. of Atoms



Protein
8689



Water
205







aValues in parenthesis refer to highest resolution shell.













TABLE 4-2





Coordinates of P. alba IspS
















HEADER
----  XX-XXX-9- xxxx


COMPND
---









REMARK
3



REMARK
3
REFINEMENT.


REMARK
3
PROGRAM   : REFMAC 5.5.0088


REMARK
3
AUTHORS  : MURSHUDOV, VAGIN, DODSON


REMARK
3


REMARK
3
REFINEMENT TARGET: MAXIMUM LIKELIHOOD


REMARK
3


REMARK
3
DATA USED IN REFINEMENT.


REMARK
3
RESOLUTION RANGE HIGH (ANGSTROMS): 2.30


REMARK
3
RESOLUTION RANGE LOW (ANGSTROMS): 43.66


REMARK
3
DATA CUTOFF (SIGMA(F)): NONE


REMARK
3
COMPLETENESS FOR RANGE  (%): 98.90


REMARK
3
NUMBER OF REFLECTIONS  : 74242


REMARK
3


REMARK
3
FIT TO DATA USED IN REFINEMENT.


REMARK
3
CROSS-VALIDATION METHOD  : THROUGHOUT


REMARK
3
FREE R VALUE TEST SET SELECTION : RANDOM  p


REMARK
3
R VALUE (WORKING + TEST SET): 0.20949


REMARK
3
R VALUE (WORKING SET): 0.20777


REMARK
3
FREE R VALUE : 0.24192


REMARK
3
FREE R VALUE TEST SET SIZE (%): 5.1


REMARK
3
FREE R VALUE TEST SET COUNT : 3968


REMARK
3


REMARK
3
FIT IN THE HIGHEST RESOLUTION BIN.


REMARK
3
TOTAL NUMBER OF BINS USED  : 20


REMARK
3
BIN RESOLUTION RANGE HIGH  : 2.300


REMARK
3
BIN RESOLUTION RANGE LOW  : 2.360


REMARK
3
REFLECTION IN BIN (WORKING SET):  5205


REMARK
3
BIN COMPLETENESS (WORKING + TEST) (%):  95.11


REMARK
3
BIN R VALUE (WORKING SET):  0.350


REMARK
3
BIN FREE R VALUE SET COUNT : 257


REMARK
3
BIN FREE R VALUE : 0.364


REMARK
3


REMARK
3
NUMBER OF NON-HYDROGEN ATOMS USED IN




REFINEMENT.


REMARK
3
ALL ATOMS  : 8894


REMARK
3


REMARK
3
B VALUES.


REMARK
3
FROM WILSON PLOT  (A**2): NULL


REMARK
3
MEAN B VALUE (OVERALL, A**2):  28.532


REMARK
3
OVERALL ANISOTROPIC B VALUE.


REMARK
3
B11 (A**2):  0.19


REMARK
3
B22 (A**2):  0.19


REMARK
3
B33 (A**2):  −0.39


REMARK
3
B12 (A**2):  −0.00


REMARK
3
B13 (A**2):  −0.00


REMARK
3
B23 (A**2):  0.00


REMARK
3


REMARK
3
ESTIMATED OVERALL COORDINATE ERROR.


REMARK
3
ESU BASED ON R VALUE  (A): 0.234


REMARK
3
ESU BASED ON FREE R VALUE  (A): 0.197


REMARK
3
ESU BASED ON MAXIMUM LIKELIHOOD  (A): 0.132


REMARK
3
ESU FOR B VALUES BASED ON MAXIMUM LIKELIHOOD




(A**2): 12.016


REMARK
3


REMARK
3
CORRELATION COEFFICIENTS.


REMARK
3
CORRELATION COEFFICIENT FO-FC  : 0.949


REMARK
3
CORRELATION COEFFICIENT FO-FC FREE: 0.932


REMARK
3


REMARK
3
RMS DEVIATIONS FROM IDEAL VALUES  COUNT  RMS




WEIGHT


REMARK
3
BOND LENGTHS REFINED ATOMS  (A): 8874 ; 0.012;




0.022


REMARK
3
BOND LENGTHS OTHERS  (A): 6064 ; 0.001 ;0.020


REMARK
3
BOND ANGLES REFINED ATOMS (DEGREES): 12007 ;




1.206 ; 1.952


REMARK
3
BOND ANGLES OTHERS (DEGREES): 14720 ; 0.851 ; 3.000


REMARK
3
TORSION ANGLES, PERIOD 1  (DEGREES): 1070 ; 5.228;




5.000


REMARK
3
TORSION ANGLES, PERIOD 2 (DEGREES): 460 ;35.290




;24.304


REMARK
3
TORSION ANGLES, PERIOD 3 (DEGREES): 1582 ;14.921




;15.000


REMARK
3
TORSION ANGLES, PERIOD 4 (DEGREES):  61 ;16.584




;15.000


REMARK
3
CHIRAL-CENTER RESTRAINTS (A**3):  1314 ; 0.072 ;




0.200


REMARK
3
GENERAL PLANES REFINED ATOMS (A):  9879 ; 0.005 ;




0.020


REMARK
3
GENERAL PLANES OTHERS  (A): 1878 ; 0.001 ;0.020


REMARK
3


REMARK
3
ISOTROPIC THERMAL FACTOR RESTRAINTS.  COUNT




RMS WEIGHT


REMARK
3
MAIN-CHAIN BOND REFINED ATOMS (A**2): 5310;




1.592; 3.000


REMARK
3
MAIN-CHAIN BOND OTHER ATOMS (A**2): 2148 ; 0.457




; 3.000


REMARK
3
MAIN-CHAIN ANGLE REFINED ATOMS (A**2): 8546 ;




3.009 ; 5.000


REMARK
3
SIDE-CHAIN BOND REFINED ATOMS (A**2): 3564 ;4.694




; 8.000


REMARK
3
SIDE-CHAIN ANGLE REFINED ATOMS (A**2): 3455;




7.036 ;11.000


REMARK
3


REMARK
3
NCS RESTRAINTS STATISTICS


REMARK
3
NUMBER OF DIFFERENT NCS GROUPS :  1


REMARK
3


REMARK
3
NCS GROUP NUMBER : 1


REMARK
3
CHAIN NAMES : A B


REMARK
3
NUMBER OF COMPONENTS NCS GROUP:  1


REMARK
3
COMPONENT C SSSEQI TO C SSSEQI CODE


REMARK
3
1 A 1 A 560 4


REMARK
3
1  B  1  B  560  4


REMARK
3
 GROUP CHAIN  COUNT RMS WEIGHT


REMARK
3
MEDIUM POSITIONAL  1  1  (A): 7275 ; 0.30 ; 0.50


REMARK
3
MEDIUM THERMAL  1  1  (A**2): 7275 ; 0.78 ; 2.00


REMARK
3


REMARK
3
TWIN DETAILS


REMARK
3
NUMBER OF TWIN DOMAINS  : NULL


REMARK
3


REMARK
3


REMARK
3
TLS DETAILS


REMARK
3
NUMBER OF TLS GROUPS : 2


REMARK
3
ATOM RECORD CONTAINS RESIDUAL B FACTORS ONLY


REMARK
3


REMARK
3
TLS GROUP :  1


REMARK
3
NUMBER OF COMPONENTS GROUP:  1


REMARK
3
COMPONENTS C SSSEQI TO C SSSEQI


REMARK
3
RESIDUE RANGE: A −10  A 9999


REMARK
3
ORIGIN FOR THE GROUP (A): 55.1340 −22.7990 1.5640


REMARK
3
T TENSOR


REMARK
3
T11: 0.1012 T22: 0.0842


REMARK
3
T33: 0.0487 T12: −0.0797


REMARK
3
T13: −0.0129 T23: −0.0050


REMARK
3
L TENSOR


REMARK
3
L11: 0.4547 L22: 1.7223


REMARK
3
L33: 0.4716 L12: −0.3910


REMARK
3
L13: 0.0096 L23: 0.1512


REMARK
3
S TENSOR


REMARK
3
S11: 0.0834 S12: −0.1118 S13: 0.0428


REMARK
3
S21: −0.0018 S22: −0.0458 S23: −0.0748


REMARK
3
S31: −0.0352 S32: 0.0105 S33: −0.0376


REMARK
3


REMARK
3
TLS GROUP : 2


REMARK
3
NUMBER OF COMPONENTS GROUP : 1


REMARK
3
COMPONENTS C SSSEQI TO C SSSEQI


REMARK
3
RESIDUE RANGE: B −10  B 9999


REMARK
3
ORIGIN FOR THE GROUP (A): 61.5680 28.1500 −20.5740


REMARK
3
T TENSOR


REMARK
3
T11: 0.1284 T22: 0.1262


REMARK
3
T33: 0.1080 T12: 0.0397


REMARK
3
T13: −0.0366 T23: 0.0120


REMARK
3
L TENSOR


REMARK
3
L11: 1.1443 L22: 0.6715


REMARK
3
L33: 0.8680 L12: 0.4490


REMARK
3
L13: 0.6089 L23: 0.2346


REMARK
3
S TENSOR


REMARK
3
S11: 0.0652 S12: 0.1638 S13: 0.0430


REMARK
3
S21: 0.0628 S22: −0.0956 S23: −0.0492


REMARK
3
S31: −0.0269 S32: 0.2044 S33: 0.0305


REMARK
3


REMARK
3


REMARK
3
BULK SOLVENT MODELLING.


REMARK
3
METHOD USED: MASK


REMARK
3
PARAMETERS FOR MASK CALCULATION


REMARK
3
VDW PROBE RADIUS : 1.40


REMARK
3
ION PROBE RADIUS : 0.80


REMARK
3
SHRINKAGE RADIUS : 0.80


REMARK
3


REMARK
3
OTHER REFINEMENT REMARKS:


REMARK
3
HYDROGENS HAVE BEEN ADDED IN THE RIDING




POSITIONS


REMARK
3
U VALUES: RESIDUAL ONLY


REMARK
3


REMARK
3
OTHER REFINEMENT REMARKS: 1. RESIDUES A39, A539,




A541 ARE


REMARK
3
RAMACHANDRAN OUTLIERS AND ARE LOCATED IN




POOR DENSITY.







LINKR ASN A 512  THR A 517  gap


LINKR  SER  B  18  ILE B 24  gap


LINKR ASN B 512  THR B 517  gap








CRYST1
156.800 156.800 142.480 90.00 90.00 90.00 P 43 21 2


SCALE1
0.006378 0.000000 0.000000 0.00000


SCALE2
−0.000000 0.006378 0.000000 0.00000


SCALE3
0.000000 −0.000000 0.007019 0.00000



















ATOM
1
N
ALA
A
23
59.766
−33.590
−29.936
1.00
64.60
A
N


ATOM
2
CA
ALA
A
23
60.006
−32.892
−28.637
1.00
65.14
A
C


ATOM
4
CB
ALA
A
23
60.361
−33.912
−27.536
1.00
65.26
A
C


ATOM
8
C
ALA
A
23
61.108
−31.833
−28.796
1.00
64.48
A
C


ATOM
9
O
ALA
A
23
62.101
−32.081
−29.489
1.00
64.58
A
O


ATOM
13
N
ASN
A
24
60.937
−30.692
−28.111
1.00
63.60
A
N


ATOM
14
CA
ASN
A
24
61.661
−29.425
−28.393
1.00
63.75
A
C


ATOM
16
CB
ASN
A
24
60.620
−28.275
−28.535
1.00
65.26
A
C


ATOM
19
CG
ASN
A
24
61.091
−27.095
−29.448
1.00
66.51
A
C


ATOM
20
OD1
ASN
A
24
62.282
−26.926
−29.744
1.00
66.15
A
O


ATOM
21
ND2
ASN
A
24
60.132
−26.265
−29.865
1.00
65.85
A
N


ATOM
24
C
ASN
A
24
62.780
−29.018
−27.379
1.00
61.71
A
C


ATOM
25
O
ASN
A
24
62.970
−29.635
−26.325
1.00
60.31
A
O


ATOM
27
N
TYR
A
25
63.472
−27.935
−27.748
1.00
59.76
A
N


ATOM
28
CA
TYR
A
25
64.743
−27.478
−27.188
1.00
57.41
A
C


ATOM
30
CB
TYR
A
25
65.795
−27.490
−28.311
1.00
56.05
A
C


ATOM
33
CG
TYR
A
25
65.932
−28.808
−29.027
1.00
47.11
A
C


ATOM
34
CD1
TYR
A
25
66.574
−29.878
−28.415
1.00
37.57
A
C


ATOM
36
CE1
TYR
A
25
66.711
−31.092
−29.059
1.00
36.77
A
C


ATOM
38
CZ
TYR
A
25
66.203
−31.268
−30.344
1.00
28.44
A
C


ATOM
39
OH
TYR
A
25
66.356
−32.509
−30.967
1.00
27.40
A
O


ATOM
41
CE2
TYR
A
25
65.558
−30.217
−30.979
1.00
25.06
A
C


ATOM
43
CD2
TYR
A
25
65.426
−28.988
−30.317
1.00
37.00
A
C


ATOM
45
C
TYR
A
25
64.687
−26.036
−26.661
1.00
57.89
A
C


ATOM
46
O
TYR
A
25
65.729
−25.384
−26.543
1.00
56.82
A
O


ATOM
48
N
GLU
A
26
63.490
−25.529
−26.363
1.00
59.48
A
N


ATOM
49
CA
GLU
A
26
63.341
−24.135
−25.907
1.00
60.53
A
C


ATOM
51
CB
GLU
A
26
61.868
−23.677
−25.947
1.00
61.98
A
C


ATOM
54
CG
GLU
A
26
61.348
−23.344
−27.364
1.00
67.81
A
C


ATOM
57
CD
GLU
A
26
61.904
−22.027
−27.939
1.00
76.35
A
C


ATOM
58
OE1
GLU
A
26
61.559
−20.940
−27.414
1.00
79.99
A
O


ATOM
59
OE2
GLU
A
26
62.671
−22.083
−28.931
1.00
78.41
A
O


ATOM
60
C
GLU
A
26
63.936
−23.968
−24.504
1.00
57.46
A
C


ATOM
61
O
GLU
A
26
63.895
−24.895
−23.710
1.00
55.07
A
O


ATOM
63
N
PRO
A
27
64.507
−22.787
−24.210
1.00
56.78
A
N


ATOM
64
CA
PRO
A
27
65.154
−22.598
−22.915
1.00
56.84
A
C


ATOM
66
CB
PRO
A
27
65.814
−21.217
−23.045
1.00
57.69
A
C


ATOM
69
CG
PRO
A
27
65.016
−20.504
−24.075
1.00
58.63
A
C


ATOM
72
CD
PRO
A
27
64.502
−21.552
−25.017
1.00
57.02
A
C


ATOM
75
C
PRO
A
27
64.169
−22.625
−21.736
1.00
55.20
A
C


ATOM
76
O
PRO
A
27
62.977
−22.370
−21.913
1.00
54.56
A
O


ATOM
77
N
ASN
A
28
64.673
−22.977
−20.560
1.00
53.26
A
N


ATOM
78
CA
ASN
A
28
63.936
−22.792
−19.328
1.00
53.80
A
C


ATOM
80
CB
ASN
A
28
64.226
−23.922
−18.345
1.00
55.37
A
C


ATOM
83
CG
ASN
A
28
63.955
−25.285
−18.938
1.00
57.15
A
C


ATOM
84
OD1
ASN
A
28
62.803
−25.708
−19.041
1.00
59.44
A
O


ATOM
85
ND2
ASN
A
28
65.019
−25.984
−19.329
1.00
56.57
A
N


ATOM
88
C
ASN
A
28
64.302
−21.453
−18.702
1.00
52.53
A
C


ATOM
89
O
ASN
A
28
65.445
−20.999
−18.790
1.00
51.17
A
O


ATOM
91
N
SER
A
29
63.318
−20.836
−18.057
1.00
52.53
A
N


ATOM
92
CA
SER
A
29
63.497
−19.563
−17.340
1.00
52.63
A
C


ATOM
94
CB
SER
A
29
62.153
−19.136
−16.735
1.00
53.29
A
C


ATOM
97
OG
SER
A
29
61.572
−20.222
−16.014
1.00
52.43
A
O


ATOM
99
C
SER
A
29
64.545
−19.616
−16.215
1.00
51.47
A
C


ATOM
100
O
SER
A
29
64.999
−18.576
−15.746
1.00
51.59
A
O


ATOM
102
N
TRP
A
30
64.891
−20.826
−15.774
1.00
50.43
A
N


ATOM
103
CA
TRP
A
30
65.901
−21.041
−14.731
1.00
50.20
A
C


ATOM
105
CB
TRP
A
30
65.343
−21.978
−13.637
1.00
50.36
A
C


ATOM
108
CG
TRP
A
30
64.573
−23.177
−14.155
1.00
51.86
A
C


ATOM
109
CD1
TRP
A
30
63.214
−23.313
−14.211
1.00
56.08
A
C


ATOM
111
NE1
TRP
A
30
62.880
−24.533
−14.750
1.00
60.74
A
N


ATOM
113
CE2
TRP
A
30
64.029
−25.215
−15.051
1.00
54.80
A
C


ATOM
114
CD2
TRP
A
30
65.119
−24.392
−14.688
1.00
51.20
A
C


ATOM
115
CE3
TRP
A
30
66.419
−24.862
−14.894
1.00
57.41
A
C


ATOM
117
CZ3
TRP
A
30
66.591
−26.131
−15.460
1.00
60.80
A
C


ATOM
119
CH2
TRP
A
30
65.483
−26.925
−15.807
1.00
61.30
A
C


ATOM
121
CZ2
TRP
A
30
64.199
−26.484
−15.611
1.00
60.79
A
C


ATOM
123
C
TRP
A
30
67.266
−21.562
−15.250
1.00
49.62
A
C


ATOM
124
O
TRP
A
30
68.187
−21.761
−14.454
1.00
48.73
A
O


ATOM
126
N
ASP
A
31
67.411
−21.778
−16.561
1.00
49.12
A
N


ATOM
127
CA
ASP
A
31
68.692
−22.273
−17.113
1.00
48.38
A
C


ATOM
129
CB
ASP
A
31
68.649
−22.407
−18.638
1.00
48.56
A
C


ATOM
132
CG
ASP
A
31
67.723
−23.505
−19.108
1.00
47.65
A
C


ATOM
133
OD1
ASP
A
31
67.602
−24.547
−18.429
1.00
50.40
A
O


ATOM
134
OD2
ASP
A
31
67.117
−23.313
−20.175
1.00
49.25
A
O


ATOM
135
C
ASP
A
31
69.801
−21.307
−16.760
1.00
47.85
A
C


ATOM
136
O
ASP
A
31
69.563
−20.102
−16.691
1.00
47.37
A
O


ATOM
138
N
TYR
A
32
71.010
−21.821
−16.546
1.00
46.83
A
N


ATOM
139
CA
TYR
A
32
72.126
−20.945
−16.201
1.00
47.06
A
C


ATOM
141
CB
TYR
A
32
73.335
−21.742
−15.707
1.00
44.99
A
C


ATOM
144
CG
TYR
A
32
73.105
−22.461
−14.388
1.00
41.43
A
C


ATOM
145
CD1
TYR
A
32
72.786
−21.755
−13.213
1.00
36.43
A
C


ATOM
147
CE1
TYR
A
32
72.587
−22.428
−12.008
1.00
26.59
A
C


ATOM
149
CZ
TYR
A
32
72.708
−23.786
−11.980
1.00
28.34
A
C


ATOM
150
OH
TYR
A
32
72.521
−24.456
−10.829
1.00
27.28
A
O


ATOM
152
CE2
TYR
A
32
73.043
−24.506
−13.113
1.00
33.62
A
C


ATOM
154
CD2
TYR
A
32
73.241
−23.843
−14.302
1.00
36.99
A
C


ATOM
156
C
TYR
A
32
72.520
−19.999
−17.343
1.00
49.23
A
C


ATOM
157
O
TYR
A
32
73.087
−18.945
−17.081
1.00
46.64
A
O


ATOM
159
N
ASP
A
33
72.229
−20.380
−18.591
1.00
53.18
A
N


ATOM
160
CA
ASP
A
33
72.441
−19.503
−19.758
1.00
56.33
A
C


ATOM
162
CB
ASP
A
33
72.191
−20.264
−21.080
1.00
56.22
A
C


ATOM
165
CG
ASP
A
33
73.311
−21.266
−21.435
1.00
55.52
A
C


ATOM
166
OD1
ASP
A
33
74.495
−21.027
−21.103
1.00
50.09
A
O


ATOM
167
OD2
ASP
A
33
73.004
−22.293
−22.087
1.00
54.49
A
O


ATOM
168
C
ASP
A
33
71.539
−18.250
−19.701
1.00
60.14
A
C


ATOM
169
O
ASP
A
33
71.973
−17.150
−20.064
1.00
59.09
A
O


ATOM
171
N
TYR
A
34
70.298
−18.429
−19.241
1.00
64.30
A
N


ATOM
172
CA
TYR
A
34
69.300
−17.346
−19.158
1.00
68.93
A
C


ATOM
174
CB
TYR
A
34
67.880
−17.942
−19.169
1.00
69.88
A
C


ATOM
177
CG
TYR
A
34
66.754
−16.929
−19.206
1.00
79.07
A
C


ATOM
178
CD1
TYR
A
34
66.346
−16.345
−20.411
1.00
87.57
A
C


ATOM
180
CE1
TYR
A
34
65.300
−15.405
−20.444
1.00
90.15
A
C


ATOM
182
CZ
TYR
A
34
64.653
−15.057
−19.261
1.00
92.74
A
C


ATOM
183
OH
TYR
A
34
63.620
−14.141
−19.270
1.00
95.62
A
O


ATOM
185
CE2
TYR
A
34
65.041
−15.631
−18.056
1.00
89.91
A
C


ATOM
187
CD2
TYR
A
34
66.084
−16.561
−18.034
1.00
85.72
A
C


ATOM
189
C
TYR
A
34
69.529
−16.449
−17.926
1.00
70.23
A
C


ATOM
190
O
TYR
A
34
69.797
−15.260
−18.063
1.00
70.32
A
O


ATOM
192
N
LEU
A
35
69.427
−17.020
−16.727
1.00
73.06
A
N


ATOM
193
CA
LEU
A
35
69.867
−16.341
−15.501
1.00
75.25
A
C


ATOM
195
CB
LEU
A
35
69.506
−17.156
−14.250
1.00
74.64
A
C


ATOM
198
CG
LEU
A
35
68.069
−17.615
−13.995
1.00
71.74
A
C


ATOM
200
CD1
LEU
A
35
68.046
−18.584
−12.822
1.00
67.99
A
C


ATOM
204
CD2
LEU
A
35
67.150
−16.432
−13.741
1.00
67.75
A
C


ATOM
208
C
LEU
A
35
71.379
−16.252
−15.592
1.00
78.42
A
C


ATOM
209
O
LEU
A
35
71.962
−16.873
−16.472
1.00
80.06
A
O


ATOM
211
N
LEU
A
36
72.028
−15.505
−14.705
1.00
81.43
A
N


ATOM
212
CA
LEU
A
36
73.494
−15.583
−14.598
1.00
84.46
A
C


ATOM
214
CB
LEU
A
36
73.881
−16.978
−14.068
1.00
84.18
A
C


ATOM
217
CG
LEU
A
36
75.259
−17.216
−13.442
1.00
84.76
A
C


ATOM
219
CD1
LEU
A
36
75.421
−16.414
−12.157
1.00
87.18
A
C


ATOM
223
CD2
LEU
A
36
75.470
−18.700
−13.189
1.00
83.02
A
C


ATOM
227
C
LEU
A
36
74.237
−15.311
−15.928
1.00
86.75
A
C


ATOM
228
O
LEU
A
36
75.330
−15.834
−16.156
1.00
86.15
A
O


ATOM
230
N
SER
A
37
73.644
−14.503
−16.805
1.00
90.20
A
N


ATOM
231
CA
SER
A
37
74.279
−14.168
−18.080
1.00
92.56
A
C


ATOM
233
CB
SER
A
37
73.237
−14.010
−19.189
1.00
92.69
A
C


ATOM
236
OG
SER
A
37
73.808
−14.292
−20.454
1.00
92.23
A
O


ATOM
238
C
SER
A
37
75.107
−12.893
−17.907
1.00
94.60
A
C


ATOM
239
O
SER
A
37
74.881
−12.121
−16.964
1.00
94.48
A
O


ATOM
241
N
SER
A
38
76.056
−12.684
−18.822
1.00
96.76
A
N


ATOM
242
CA
SER
A
38
77.120
−11.683
−18.643
1.00
98.37
A
C


ATOM
244
CB
SER
A
38
78.236
−11.866
−19.687
1.00
98.25
A
C


ATOM
247
OG
SER
A
38
77.731
−11.924
−21.008
1.00
97.84
A
O


ATOM
249
C
SER
A
38
76.642
−10.232
−18.666
1.00
99.95
A
C


ATOM
250
O
SER
A
38
76.185
−9.731
−19.698
1.00
100.18
A
O


ATOM
252
N
ASP
A
39
76.771
−9.569
−17.517
1.00
101.78
A
N


ATOM
253
CA
ASP
A
39
76.622
−8.115
−17.417
1.00
103.16
A
C


ATOM
255
CB
ASP
A
39
76.312
−7.727
−15.956
1.00
103.31
A
C


ATOM
258
CG
ASP
A
39
75.475
−6.452
−15.835
1.00
103.40
A
C


ATOM
259
OD1
ASP
A
39
75.487
−5.615
−16.765
1.00
100.38
A
O


ATOM
260
OD2
ASP
A
39
74.804
−6.290
−14.792
1.00
103.82
A
O


ATOM
261
C
ASP
A
39
77.945
−7.505
−17.942
1.00
104.15
A
C


ATOM
262
O
ASP
A
39
78.518
−8.032
−18.904
1.00
104.67
A
O


ATOM
264
N
THR
A
40
78.436
−6.414
−17.343
1.00
104.86
A
N


ATOM
265
CA
THR
A
40
79.818
−5.955
−17.599
1.00
105.03
A
C


ATOM
267
CB
THR
A
40
79.942
−4.397
−17.544
1.00
105.17
A
C


ATOM
269
OG1
THR
A
40
78.774
−3.789
−18.111
1.00
104.08
A
O


ATOM
271
CG2
THR
A
40
81.187
−3.917
−18.306
1.00
103.97
A
C


ATOM
275
C
THR
A
40
80.802
−6.605
−16.594
1.00
105.16
A
C


ATOM
276
O
THR
A
40
81.804
−5.992
−16.206
1.00
105.14
A
O


ATOM
278
N
ASP
A
41
80.509
−7.851
−16.198
1.00
104.87
A
N


ATOM
279
CA
ASP
A
41
81.285
−8.600
−15.198
1.00
104.03
A
C


ATOM
281
CB
ASP
A
41
80.400
−8.951
−13.991
1.00
103.68
A
C


ATOM
284
CG
ASP
A
41
80.063
−7.737
−13.126
1.00
103.58
A
C


ATOM
285
OD1
ASP
A
41
80.402
−6.594
−13.506
1.00
101.01
A
O


ATOM
286
OD2
ASP
A
41
79.455
−7.929
−12.053
1.00
103.04
A
O


ATOM
287
C
ASP
A
41
81.884
−9.883
−15.807
1.00
103.35
A
C


ATOM
288
O
ASP
A
41
81.159
−10.738
−16.329
1.00
102.89
A
O


ATOM
290
N
GLU
A
42
83.210
−10.005
−15.715
1.00
102.70
A
N


ATOM
291
CA
GLU
A
42
83.965
−11.067
−16.392
1.00
102.05
A
C


ATOM
293
CB
GLU
A
42
85.477
−10.775
−16.342
1.00
101.98
A
C


ATOM
296
CG
GLU
A
42
85.924
−9.517
−17.102
1.00
101.14
A
C


ATOM
299
CD
GLU
A
42
87.445
−9.357
−17.170
1.00
99.92
A
C


ATOM
300
OE1
GLU
A
42
88.174
−10.198
−16.603
1.00
99.06
A
O


ATOM
301
OE2
GLU
A
42
87.916
−8.384
−17.797
1.00
96.85
A
O


ATOM
302
C
GLU
A
42
83.700
−12.466
−15.820
1.00
101.77
A
C


ATOM
303
O
GLU
A
42
83.463
−13.410
−16.582
1.00
102.06
A
O


ATOM
305
N
SER
A
43
83.748
−12.599
−14.491
1.00
100.69
A
N


ATOM
306
CA
SER
A
43
83.632
−13.915
−13.829
1.00
99.39
A
C


ATOM
308
CB
SER
A
43
84.695
−14.072
−12.721
1.00
99.42
A
C


ATOM
311
OG
SER
A
43
84.503
−13.160
−11.657
1.00
98.04
A
O


ATOM
313
C
SER
A
43
82.213
−14.252
−13.308
1.00
97.81
A
C


ATOM
314
O
SER
A
43
82.054
−15.108
−12.424
1.00
96.95
A
O


ATOM
316
N
ILE
A
44
81.195
−13.579
−13.859
1.00
95.85
A
N


ATOM
317
CA
ILE
A
44
79.816
−14.092
−13.827
1.00
94.49
A
C


ATOM
319
CB
ILE
A
44
78.734
−12.989
−14.132
1.00
94.92
A
C


ATOM
321
CG1
ILE
A
44
78.344
−12.217
−12.858
1.00
95.86
A
C


ATOM
324
CD1
ILE
A
44
77.084
−11.338
−13.006
1.00
93.80
A
C


ATOM
328
CG2
ILE
A
44
77.467
−13.603
−14.731
1.00
94.41
A
C


ATOM
332
C
ILE
A
44
79.704
−15.251
−14.832
1.00
92.51
A
C


ATOM
333
O
ILE
A
44
78.815
−16.099
−14.698
1.00
91.97
A
O


ATOM
335
N
GLU
A
45
80.615
−15.284
−15.817
1.00
90.17
A
N


ATOM
336
CA
GLU
A
45
80.662
−16.342
−16.845
1.00
88.08
A
C


ATOM
338
CB
GLU
A
45
81.071
−15.768
−18.205
1.00
88.74
A
C


ATOM
341
CG
GLU
A
45
79.979
−14.922
−18.864
1.00
91.64
A
C


ATOM
344
CD
GLU
A
45
79.561
−15.416
−20.250
1.00
94.30
A
C


ATOM
345
OE1
GLU
A
45
80.265
−16.268
−20.839
1.00
95.27
A
O


ATOM
346
OE2
GLU
A
45
78.513
−14.946
−20.746
1.00
92.80
A
O


ATOM
347
C
GLU
A
45
81.570
−17.536
−16.521
1.00
85.08
A
C


ATOM
348
O
GLU
A
45
81.331
−18.638
−17.021
1.00
84.95
A
O


ATOM
350
N
VAL
A
46
82.620
−17.323
−15.727
1.00
81.35
A
N


ATOM
351
CA
VAL
A
46
83.420
−18.442
−15.202
1.00
78.09
A
C


ATOM
353
CB
VAL
A
46
84.741
−17.959
−14.548
1.00
78.08
A
C


ATOM
355
CG1
VAL
A
46
85.516
−19.136
−13.944
1.00
78.15
A
C


ATOM
359
CG2
VAL
A
46
85.603
−17.213
−15.570
1.00
79.62
A
C


ATOM
363
C
VAL
A
46
82.583
−19.247
−14.187
1.00
74.06
A
C


ATOM
364
O
VAL
A
46
82.718
−20.472
−14.090
1.00
73.88
A
O


ATOM
366
N
TYR
A
47
81.728
−18.528
−13.451
1.00
68.93
A
N


ATOM
367
CA
TYR
A
47
80.741
−19.086
−12.512
1.00
65.54
A
C


ATOM
369
CB
TYR
A
47
80.142
−17.905
−11.718
1.00
65.84
A
C


ATOM
372
CG
TYR
A
47
79.247
−18.192
−10.516
1.00
68.89
A
C


ATOM
373
CD1
TYR
A
47
79.776
−18.352
−9.229
1.00
72.76
A
C


ATOM
375
CE1
TYR
A
47
78.930
−18.585
−8.113
1.00
72.95
A
C


ATOM
377
CZ
TYR
A
47
77.542
−18.631
−8.291
1.00
72.91
A
C


ATOM
378
OH
TYR
A
47
76.679
−18.853
−7.222
1.00
53.89
A
O


ATOM
380
CE2
TYR
A
47
77.008
−18.448
−9.560
1.00
71.64
A
C


ATOM
382
CD2
TYR
A
47
77.859
−18.216
−10.655
1.00
72.02
A
C


ATOM
384
C
TYR
A
47
79.658
−19.899
−13.280
1.00
61.30
A
C


ATOM
385
O
TYR
A
47
79.353
−21.044
−12.929
1.00
59.34
A
O


ATOM
387
N
LYS
A
48
79.109
−19.287
−14.333
1.00
56.43
A
N


ATOM
388
CA
LYS
A
48
78.171
−19.918
−15.284
1.00
52.55
A
C


ATOM
390
CB
LYS
A
48
77.920
−18.945
−16.451
1.00
53.28
A
C


ATOM
393
CG
LYS
A
48
76.989
−19.391
−17.592
1.00
55.50
A
C


ATOM
396
CD
LYS
A
48
77.428
−18.712
−18.913
1.00
61.02
A
C


ATOM
399
CE
LYS
A
48
76.323
−18.612
−19.970
1.00
65.42
A
C


ATOM
402
NZ
LYS
A
48
75.608
−17.279
−19.985
1.00
66.42
A
N


ATOM
406
C
LYS
A
48
78.673
−21.255
−15.828
1.00
47.94
A
C


ATOM
407
O
LYS
A
48
78.023
−22.273
−15.643
1.00
47.33
A
O


ATOM
409
N
ASP
A
49
79.822
−21.250
−16.496
1.00
44.41
A
N


ATOM
410
CA
ASP
A
49
80.382
−22.471
−17.087
1.00
43.52
A
C


ATOM
412
CB
ASP
A
49
81.659
−22.188
−17.915
1.00
44.86
A
C


ATOM
415
CG
ASP
A
49
81.387
−21.342
−19.179
1.00
48.93
A
C


ATOM
416
OD1
ASP
A
49
80.230
−21.330
−19.679
1.00
53.55
A
O


ATOM
417
OD2
ASP
A
49
82.339
−20.689
−19.670
1.00
47.52
A
O


ATOM
418
C
ASP
A
49
80.680
−23.512
−16.011
1.00
41.34
A
C


ATOM
419
O
ASP
A
49
80.564
−24.715
−16.263
1.00
39.75
A
O


ATOM
421
N
LYS
A
50
81.052
−23.055
−14.813
1.00
39.19
A
N


ATOM
422
CA
LYS
A
50
81.252
−23.967
−13.693
1.00
37.19
A
C


ATOM
424
CB
LYS
A
50
81.870
−23.260
−12.480
1.00
39.17
A
C


ATOM
427
CG
LYS
A
50
82.291
−24.204
−11.330
1.00
44.35
A
C


ATOM
430
CD
LYS
A
50
82.896
−23.401
−10.166
1.00
55.34
A
C


ATOM
433
CE
LYS
A
50
84.411
−23.260
−10.273
1.00
59.44
A
C


ATOM
436
NZ
LYS
A
50
84.866
−21.942
−9.757
1.00
57.35
A
N


ATOM
440
C
LYS
A
50
79.920
−24.617
−13.344
1.00
33.13
A
C


ATOM
441
O
LYS
A
50
79.846
−25.845
−13.254
1.00
31.70
A
O


ATOM
443
N
ALA
A
51
78.862
−23.813
−13.195
1.00
28.95
A
N


ATOM
444
CA
ALA
A
51
77.540
−24.361
−12.872
1.00
27.76
A
C


ATOM
446
CB
ALA
A
51
76.523
−23.233
−12.640
1.00
27.51
A
C


ATOM
450
C
ALA
A
51
77.030
−25.359
−13.942
1.00
26.48
A
C


ATOM
451
O
ALA
A
51
76.596
−26.462
−13.615
1.00
28.45
A
O


ATOM
453
N
LYS
A
52
77.104
−24.980
−15.212
1.00
25.84
A
N


ATOM
454
CA
LYS
A
52
76.704
−25.867
−16.319
1.00
25.55
A
C


ATOM
456
CB
LYS
A
52
77.062
−25.228
−17.679
1.00
25.87
A
C


ATOM
459
CG
LYS
A
52
76.061
−24.158
−18.106
1.00
30.35
A
C


ATOM
462
CD
LYS
A
52
76.635
−23.079
−19.007
1.00
29.72
A
C


ATOM
465
CE
LYS
A
52
76.636
−23.486
−20.493
1.00
39.59
A
C


ATOM
468
NZ
LYS
A
52
77.217
−22.424
−21.416
1.00
37.70
A
N


ATOM
472
C
LYS
A
52
77.345
−27.247
−16.217
1.00
25.06
A
C


ATOM
473
O
LYS
A
52
76.678
−28.266
−16.388
1.00
24.13
A
O


ATOM
475
N
LYS
A
53
78.647
−27.270
−15.941
1.00
25.32
A
N


ATOM
476
CA
LYS
A
53
79.407
−28.529
−15.862
1.00
26.67
A
C


ATOM
478
CB
LYS
A
53
80.915
−28.230
−15.729
1.00
28.91
A
C


ATOM
481
CG
LYS
A
53
81.781
−29.479
−15.584
1.00
38.89
A
C


ATOM
484
CD
LYS
A
53
83.274
−29.214
−15.866
1.00
51.52
A
C


ATOM
487
CE
LYS
A
53
84.101
−30.510
−15.696
1.00
55.41
A
C


ATOM
490
NZ
LYS
A
53
85.467
−30.399
−16.280
1.00
56.50
A
N


ATOM
494
C
LYS
A
53
78.940
−29.439
−14.705
1.00
23.90
A
C


ATOM
495
O
LYS
A
53
78.751
−30.648
−14.893
1.00
21.50
A
O


ATOM
497
N
LEU
A
54
78.770
−28.847
−13.523
1.00
20.73
A
N


ATOM
498
CA
LEU
A
54
78.317
−29.568
−12.343
1.00
21.72
A
C


ATOM
500
CB
LEU
A
54
78.280
−28.637
−11.120
1.00
21.06
A
C


ATOM
503
CG
LEU
A
54
79.601
−27.919
−10.778
1.00
26.70
A
C


ATOM
505
CD1
LEU
A
54
79.389
−26.832
−9.753
1.00
21.18
A
C


ATOM
509
CD2
LEU
A
54
80.674
−28.909
−10.299
1.00
27.08
A
C


ATOM
513
C
LEU
A
54
76.927
−30.132
−12.611
1.00
21.21
A
C


ATOM
514
O
LEU
A
54
76.642
−31.304
−12.353
1.00
21.09
A
O


ATOM
516
N
GLU
A
55
76.073
−29.270
−13.144
1.00
21.62
A
N


ATOM
517
CA
GLU
A
55
74.692
−29.602
−13.409
1.00
20.09
A
C


ATOM
519
CB
GLU
A
55
73.961
−28.375
−13.955
1.00
20.04
A
C


ATOM
522
CG
GLU
A
55
72.497
−28.639
−14.395
1.00
25.33
A
C


ATOM
525
CD
GLU
A
55
71.880
−27.437
−15.100
1.00
25.76
A
C


ATOM
526
OE1
GLU
A
55
72.558
−26.836
−15.953
1.00
27.45
A
O


ATOM
527
OE2
GLU
A
55
70.731
−27.095
−14.790
1.00
28.92
A
O


ATOM
528
C
GLU
A
55
74.614
−30.736
−14.410
1.00
19.08
A
C


ATOM
529
O
GLU
A
55
73.764
−31.614
−14.286
1.00
17.95
A
O


ATOM
531
N
ALA
A
56
75.505
−30.721
−15.396
1.00
18.58
A
N


ATOM
532
CA
ALA
A
56
75.516
−31.770
−16.419
1.00
18.68
A
C


ATOM
534
CB
ALA
A
56
76.589
−31.476
−17.477
1.00
17.67
A
C


ATOM
538
C
ALA
A
56
75.782
−33.105
−15.784
1.00
18.70
A
C


ATOM
539
O
ALA
A
56
75.164
−34.107
−16.140
1.00
21.50
A
O


ATOM
541
N
GLU
A
57
76.717
−33.118
−14.840
1.00
19.66
A
N


ATOM
542
CA
GLU
A
57
77.138
−34.352
−14.191
1.00
19.60
A
C


ATOM
544
CB
GLU
A
57
78.451
−34.147
−13.404
1.00
21.64
A
C


ATOM
547
CG
GLU
A
57
78.990
−35.425
−12.709
1.00
27.13
A
C


ATOM
550
CD
GLU
A
57
80.415
−35.275
−12.139
1.00
28.89
A
C


ATOM
551
OE1
GLU
A
57
81.165
−34.363
−12.546
1.00
30.32
A
O


ATOM
552
OE2
GLU
A
57
80.781
−36.104
−11.276
1.00
36.69
A
O


ATOM
553
C
GLU
A
57
76.009
−34.867
−13.316
1.00
18.61
A
C


ATOM
554
O
GLU
A
57
75.731
−36.037
−13.348
1.00
19.99
A
O


ATOM
556
N
VAL
A
58
75.313
−33.996
−12.580
1.00
19.50
A
N


ATOM
557
CA
VAL
A
58
74.171
−34.452
−11.772
1.00
18.20
A
C


ATOM
559
CB
VAL
A
58
73.603
−33.329
−10.893
1.00
21.45
A
C


ATOM
561
CG1
VAL
A
58
72.374
−33.841
−10.141
1.00
16.09
A
C


ATOM
565
CG2
VAL
A
58
74.659
−32.800
−9.918
1.00
17.59
A
C


ATOM
569
C
VAL
A
58
73.062
−35.007
−12.676
1.00
18.18
A
C


ATOM
570
O
VAL
A
58
72.461
−36.063
−12.402
1.00
17.53
A
O


ATOM
572
N
ARG
A
59
72.841
−34.337
−13.802
1.00
20.36
A
N


ATOM
573
CA
ARG
A
59
71.896
−34.833
−14.819
1.00
19.83
A
C


ATOM
575
CB
ARG
A
59
71.891
−33.923
−16.049
1.00
20.72
A
C


ATOM
578
CG
ARG
A
59
70.959
−34.357
−17.180
1.00
21.44
A
C


ATOM
581
CD
ARG
A
59
71.656
−35.311
−18.172
1.00
26.88
A
C


ATOM
584
NE
ARG
A
59
70.756
−35.765
−19.235
1.00
26.75
A
N


ATOM
586
CZ
ARG
A
59
70.980
−36.808
−20.035
1.00
27.29
A
C


ATOM
587
NH1
ARG
A
59
70.079
−37.128
−20.948
1.00
26.52
A
N


ATOM
590
NH2
ARG
A
59
72.106
−37.527
−19.954
1.00
26.33
A
N


ATOM
593
C
ARG
A
59
72.271
−36.239
−15.210
1.00
20.53
A
C


ATOM
594
O
ARG
A
59
71.435
−37.137
−15.233
1.00
21.41
A
O


ATOM
596
N
ARG
A
60
73.546
−36.445
−15.495
1.00
21.14
A
N


ATOM
597
CA
ARG
A
60
73.988
−37.755
−15.936
1.00
19.56
A
C


ATOM
599
CB
ARG
A
60
75.477
−37.765
−16.209
1.00
19.04
A
C


ATOM
602
CG
ARG
A
60
75.986
−39.109
−16.690
1.00
21.95
A
C


ATOM
605
CD
ARG
A
60
77.465
−39.067
−16.905
1.00
21.61
A
C


ATOM
608
NE
ARG
A
60
78.162
−38.960
−15.637
1.00
25.86
A
N


ATOM
610
CZ
ARG
A
60
79.450
−38.659
−15.502
1.00
27.72
A
C


ATOM
611
NH1
ARG
A
60
79.957
−38.595
−14.288
1.00
27.66
A
N


ATOM
614
NH2
ARG
A
60
80.239
−38.429
−16.561
1.00
24.85
A
N


ATOM
617
C
ARG
A
60
73.680
−38.834
−14.910
1.00
20.09
A
C


ATOM
618
O
ARG
A
60
73.184
−39.907
−15.260
1.00
19.04
A
O


ATOM
620
N
GLU
A
61
73.987
−38.556
−13.652
1.00
21.36
A
N


ATOM
621
CA
GLU
A
61
73.834
−39.565
−12.586
1.00
21.08
A
C


ATOM
623
CB
GLU
A
61
74.503
−39.095
−11.291
1.00
20.78
A
C


ATOM
626
CG
GLU
A
61
76.019
−38.914
−11.424
1.00
29.32
A
C


ATOM
629
CD
GLU
A
61
76.700
−40.205
−11.825
1.00
33.44
A
C


ATOM
630
OE1
GLU
A
61
76.614
−41.174
−11.038
1.00
32.69
A
O


ATOM
631
OE2
GLU
A
61
77.297
−40.251
−12.930
1.00
36.93
A
O


ATOM
632
C
GLU
A
61
72.376
−39.954
−12.308
1.00
19.59
A
C


ATOM
633
O
GLU
A
61
72.124
−41.076
−11.938
1.00
21.54
A
O


ATOM
635
N
ILE
A
62
71.443
−39.024
−12.485
1.00
20.46
A
N


ATOM
636
CA
ILE
A
62
70.019
−39.298
−12.290
1.00
20.63
A
C


ATOM
638
CB
ILE
A
62
69.195
−38.010
−12.148
1.00
20.75
A
C


ATOM
640
CG1
ILE
A
62
69.651
−37.184
−10.937
1.00
20.34
A
C


ATOM
643
CD1
ILE
A
62
69.052
−35.781
−10.885
1.00
17.82
A
C


ATOM
647
CG2
ILE
A
62
67.708
−38.363
−12.000
1.00
21.70
A
C


ATOM
651
C
ILE
A
62
69.462
−40.108
−13.462
1.00
22.58
A
C


ATOM
652
O
ILE
A
62
68.548
−40.895
−13.298
1.00
23.12
A
O


ATOM
654
N
ASN
A
63
70.008
−39.899
−14.656
1.00
24.14
A
N


ATOM
655
CA
ASN
A
63
69.567
−40.628
−15.840
1.00
22.08
A
C


ATOM
657
CB
ASN
A
63
69.839
−39.776
−17.071
1.00
20.09
A
C


ATOM
660
CG
ASN
A
63
68.812
−38.693
−17.256
1.00
24.05
A
C


ATOM
661
OD1
ASN
A
63
67.809
−38.925
−17.893
1.00
28.24
A
O


ATOM
662
ND2
ASN
A
63
69.063
−37.493
−16.717
1.00
22.91
A
N


ATOM
665
C
ASN
A
63
70.232
−41.999
−15.980
1.00
23.43
A
C


ATOM
666
O
ASN
A
63
69.809
−42.829
−16.783
1.00
25.36
A
O


ATOM
668
N
ASN
A
64
71.277
−42.226
−15.194
1.00
25.57
A
N


ATOM
669
CA
ASN
A
64
72.064
−43.451
−15.242
1.00
27.94
A
C


ATOM
671
CB
ASN
A
64
73.151
−43.357
−14.165
1.00
27.54
A
C


ATOM
674
CG
ASN
A
64
74.104
−44.557
−14.138
1.00
30.25
A
C


ATOM
675
OD1
ASN
A
64
74.164
−45.350
−15.074
1.00
24.98
A
O


ATOM
676
ND2
ASN
A
64
74.876
−44.666
−13.054
1.00
20.45
A
N


ATOM
679
C
ASN
A
64
71.185
−44.656
−14.992
1.00
30.41
A
C


ATOM
680
O
ASN
A
64
70.691
−44.821
−13.892
1.00
32.21
A
O


ATOM
682
N
GLU
A
65
71.004
−45.516
−15.989
1.00
33.50
A
N


ATOM
683
CA
GLU
A
65
70.150
−46.701
−15.800
1.00
35.73
A
C


ATOM
685
CB
GLU
A
65
69.578
−47.175
−17.129
1.00
36.73
A
C


ATOM
688
CG
GLU
A
65
68.675
−46.102
−17.762
1.00
41.17
A
C


ATOM
691
CD
GLU
A
65
67.803
−46.596
−18.908
1.00
48.22
A
C


ATOM
692
OE1
GLU
A
65
67.712
−47.831
−19.150
1.00
47.55
A
O


ATOM
693
OE2
GLU
A
65
67.194
−45.716
−19.562
1.00
48.75
A
O


ATOM
694
C
GLU
A
65
70.871
−47.836
−15.094
1.00
36.68
A
C


ATOM
695
O
GLU
A
65
70.240
−48.776
−14.634
1.00
37.20
A
O


ATOM
697
N
LYS
A
66
72.189
−47.730
−14.984
1.00
36.43
A
N


ATOM
698
CA
LYS
A
66
72.999
−48.790
−14.404
1.00
37.11
A
C


ATOM
700
CB
LYS
A
66
74.383
−48.828
−15.084
1.00
38.18
A
C


ATOM
703
CG
LYS
A
66
74.340
−48.999
−16.621
1.00
41.19
A
C


ATOM
706
CD
LYS
A
66
75.757
−48.982
−17.252
1.00
47.45
A
C


ATOM
709
CE
LYS
A
66
75.731
−49.109
−18.801
1.00
47.41
A
C


ATOM
712
NZ
LYS
A
66
74.829
−50.210
−19.287
1.00
47.24
A
N


ATOM
716
C
LYS
A
66
73.166
−48.635
−12.890
1.00
35.98
A
C


ATOM
717
O
LYS
A
66
73.803
−49.470
−12.252
1.00
36.59
A
O


ATOM
719
N
ALA
A
67
72.594
−47.585
−12.309
1.00
35.32
A
N


ATOM
720
CA
ALA
A
67
72.761
−47.334
−10.869
1.00
35.29
A
C


ATOM
722
CB
ALA
A
67
72.338
−45.929
−10.522
1.00
34.33
A
C


ATOM
726
C
ALA
A
67
71.970
−48.331
−10.027
1.00
35.67
A
C


ATOM
727
O
ALA
A
67
70.907
−48.823
−10.436
1.00
34.29
A
O


ATOM
729
N
GLU
A
68
72.502
−48.627
−8.850
1.00
36.18
A
N


ATOM
730
CA
GLU
A
68
71.759
−49.403
−7.869
1.00
38.84
A
C


ATOM
732
CB
GLU
A
68
72.619
−49.725
−6.645
1.00
40.31
A
C


ATOM
735
CG
GLU
A
68
72.545
−51.178
−6.224
1.00
51.58
A
C


ATOM
738
CD
GLU
A
68
73.198
−52.108
−7.240
1.00
62.21
A
C


ATOM
739
OE1
GLU
A
68
74.352
−51.827
−7.646
1.00
67.12
A
O


ATOM
740
OE2
GLU
A
68
72.558
−53.114
−7.632
1.00
64.39
A
O


ATOM
741
C
GLU
A
68
70.558
−48.554
−7.476
1.00
38.64
A
C


ATOM
742
O
GLU
A
68
70.672
−47.332
−7.342
1.00
37.36
A
O


ATOM
744
N
PHE
A
69
69.407
−49.194
−7.315
1.00
39.25
A
N


ATOM
745
CA
PHE
A
69
68.163
−48.453
−7.180
1.00
41.61
A
C


ATOM
747
CB
PHE
A
69
66.925
−49.361
−7.351
1.00
43.96
A
C


ATOM
750
CG
PHE
A
69
66.460
−49.487
−8.795
1.00
54.44
A
C


ATOM
751
CD1
PHE
A
69
66.310
−48.336
−9.610
1.00
61.05
A
C


ATOM
753
CE1
PHE
A
69
65.882
−48.429
−10.943
1.00
61.96
A
C


ATOM
755
CZ
PHE
A
69
65.586
−49.684
−11.483
1.00
65.52
A
C


ATOM
757
CE2
PHE
A
69
65.728
−50.846
−10.681
1.00
65.07
A
C


ATOM
759
CD2
PHE
A
69
66.161
−50.739
−9.344
1.00
62.25
A
C


ATOM
761
C
PHE
A
69
68.094
−47.639
−5.889
1.00
39.35
A
C


ATOM
762
O
PHE
A
69
67.620
−46.506
−5.906
1.00
34.88
A
O


ATOM
764
N
LEU
A
70
68.605
−48.185
−4.793
1.00
38.05
A
N


ATOM
765
CA
LEU
A
70
68.642
−47.417
−3.547
1.00
37.39
A
C


ATOM
767
CB
LEU
A
70
68.989
−48.320
−2.367
1.00
38.91
A
C


ATOM
770
CG
LEU
A
70
68.749
−47.727
−0.970
1.00
45.09
A
C


ATOM
772
CD1
LEU
A
70
67.365
−47.093
−0.854
1.00
42.32
A
C


ATOM
776
CD2
LEU
A
70
68.950
−48.819
0.092
1.00
48.11
A
C


ATOM
780
C
LEU
A
70
69.585
−46.208
−3.616
1.00
35.24
A
C


ATOM
781
O
LEU
A
70
69.273
−45.134
−3.076
1.00
33.59
A
O


ATOM
783
N
THR
A
71
70.715
−46.351
−4.308
1.00
32.18
A
N


ATOM
784
CA
THR
A
71
71.664
−45.232
−4.462
1.00
30.26
A
C


ATOM
786
CB
THR
A
71
72.975
−45.686
−5.151
1.00
31.18
A
C


ATOM
788
OG1
THR
A
71
73.583
−46.737
−4.380
1.00
35.88
A
O


ATOM
790
CG2
THR
A
71
73.957
−44.539
−5.269
1.00
32.21
A
C


ATOM
794
C
THR
A
71
71.023
−44.120
−5.277
1.00
27.98
A
C


ATOM
795
O
THR
A
71
71.215
−42.940
−5.011
1.00
29.70
A
O


ATOM
797
N
LEU
A
72
70.235
−44.508
−6.258
1.00
25.13
A
N


ATOM
798
CA
LEU
A
72
69.560
−43.566
−7.120
1.00
25.64
A
C


ATOM
800
CB
LEU
A
72
68.879
−44.315
−8.262
1.00
24.76
A
C


ATOM
803
CG
LEU
A
72
68.348
−43.417
−9.367
1.00
33.13
A
C


ATOM
805
CD1
LEU
A
72
69.500
−42.625
−9.999
1.00
34.90
A
C


ATOM
809
CD2
LEU
A
72
67.635
−44.244
−10.419
1.00
33.87
A
C


ATOM
813
C
LEU
A
72
68.515
−42.792
−6.344
1.00
25.13
A
C


ATOM
814
O
LEU
A
72
68.442
−41.559
−6.423
1.00
24.06
A
O


ATOM
816
N
LEU
A
73
67.705
−43.530
−5.593
1.00
24.72
A
N


ATOM
817
CA
LEU
A
73
66.685
−42.926
−4.767
1.00
24.94
A
C


ATOM
819
CB
LEU
A
73
65.863
−43.986
−4.053
1.00
25.13
A
C


ATOM
822
CG
LEU
A
73
65.002
−44.831
−4.983
1.00
24.35
A
C


ATOM
824
CD1
LEU
A
73
64.535
−46.087
−4.255
1.00
25.41
A
C


ATOM
828
CD2
LEU
A
73
63.853
−44.027
−5.559
1.00
20.54
A
C


ATOM
832
C
LEU
A
73
67.279
−41.941
−3.776
1.00
24.82
A
C


ATOM
833
O
LEU
A
73
66.697
−40.868
−3.534
1.00
24.80
A
O


ATOM
835
N
GLU
A
74
68.432
−42.287
−3.213
1.00
23.25
A
N


ATOM
836
CA
GLU
A
74
69.094
−41.412
−2.258
1.00
23.34
A
C


ATOM
838
CB
GLU
A
74
70.095
−42.214
−1.406
1.00
24.35
A
C


ATOM
841
CG
GLU
A
74
69.391
−43.188
−0.427
1.00
32.72
A
C


ATOM
844
CD
GLU
A
74
70.321
−43.919
0.537
1.00
43.15
A
C


ATOM
845
OE1
GLU
A
74
71.558
−43.826
0.407
1.00
44.90
A
O


ATOM
846
OE2
GLU
A
74
69.799
−44.603
1.438
1.00
48.93
A
O


ATOM
847
C
GLU
A
74
69.729
−40.186
−2.941
1.00
22.43
A
C


ATOM
848
O
GLU
A
74
69.785
−39.096
−2.362
1.00
24.16
A
O


ATOM
850
N
LEU
A
75
70.183
−40.335
−4.177
1.00
22.16
A
N


ATOM
851
CA
LEU
A
75
70.613
−39.180
−4.959
1.00
20.37
A
C


ATOM
853
CB
LEU
A
75
71.150
−39.622
−6.304
1.00
22.89
A
C


ATOM
856
CG
LEU
A
75
71.569
−38.495
−7.268
1.00
22.68
A
C


ATOM
858
CD1
LEU
A
75
72.741
−37.711
−6.687
1.00
15.06
A
C


ATOM
862
CD2
LEU
A
75
71.934
−39.153
−8.602
1.00
25.81
A
C


ATOM
866
C
LEU
A
75
69.465
−38.220
−5.224
1.00
20.23
A
C


ATOM
867
O
LEU
A
75
69.629
−37.017
−5.137
1.00
23.40
A
O


ATOM
869
N
ILE
A
76
68.307
−38.754
−5.582
1.00
21.55
A
N


ATOM
870
CA
ILE
A
76
67.174
−37.912
−5.923
1.00
23.06
A
C


ATOM
872
CB
ILE
A
76
65.974
−38.746
−6.401
1.00
22.62
A
C


ATOM
874
CG1
ILE
A
76
66.259
−39.323
−7.790
1.00
24.94
A
C


ATOM
877
CD1
ILE
A
76
65.388
−40.527
−8.171
1.00
19.96
A
C


ATOM
881
CG2
ILE
A
76
64.717
−37.881
−6.400
1.00
19.22
A
C


ATOM
885
C
ILE
A
76
66.755
−37.093
−4.711
1.00
24.28
A
C


ATOM
886
O
ILE
A
76
66.472
−35.896
−4.821
1.00
26.54
A
O


ATOM
888
N
ASP
A
77
66.717
−37.761
−3.563
1.00
23.78
A
N


ATOM
889
CA
ASP
A
77
66.327
−37.154
−2.298
1.00
24.77
A
C


ATOM
891
CB
ASP
A
77
66.306
−38.227
−1.200
1.00
23.52
A
C


ATOM
894
CG
ASP
A
77
65.627
−37.769
0.071
1.00
30.63
A
C


ATOM
895
OD1
ASP
A
77
64.773
−36.826
0.038
1.00
30.60
A
O


ATOM
896
OD2
ASP
A
77
65.941
−38.387
1.119
1.00
33.55
A
O


ATOM
897
C
ASP
A
77
67.308
−36.068
−1.909
1.00
25.16
A
C


ATOM
898
O
ASP
A
77
66.907
−34.999
−1.440
1.00
24.30
A
O


ATOM
900
N
ASN
A
78
68.602
−36.348
−2.093
1.00
25.18
A
N


ATOM
901
CA
ASN
A
78
69.643
−35.372
−1.765
1.00
23.87
A
C


ATOM
903
CB
ASN
A
78
71.032
−36.003
−1.918
1.00
27.24
A
C


ATOM
906
CG
ASN
A
78
71.448
−36.844
−0.701
1.00
29.01
A
C


ATOM
907
OD1
ASN
A
78
71.108
−36.503
0.421
1.00
29.64
A
O


ATOM
908
ND2
ASN
A
78
72.208
−37.933
−0.928
1.00
22.29
A
N


ATOM
911
C
ASN
A
78
69.482
−34.154
−2.679
1.00
23.28
A
C


ATOM
912
O
ASN
A
78
69.488
−32.988
−2.235
1.00
22.07
A
O


ATOM
914
N
VAL
A
79
69.293
−34.431
−3.962
1.00
21.38
A
N


ATOM
915
CA
VAL
A
79
69.097
−33.364
−4.947
1.00
22.16
A
C


ATOM
917
CB
VAL
A
79
68.883
−33.961
−6.357
1.00
23.08
A
C


ATOM
919
CG1
VAL
A
79
68.336
−32.907
−7.305
1.00
19.92
A
C


ATOM
923
CG2
VAL
A
79
70.195
−34.593
−6.876
1.00
18.18
A
C


ATOM
927
C
VAL
A
79
67.892
−32.487
−4.573
1.00
21.06
A
C


ATOM
928
O
VAL
A
79
67.950
−31.257
−4.642
1.00
22.39
A
O


ATOM
930
N
GLN
A
80
66.805
−33.109
−4.155
1.00
20.41
A
N


ATOM
931
CA
GLN
A
80
65.613
−32.315
−3.760
1.00
21.13
A
C


ATOM
933
CB
GLN
A
80
64.376
−33.203
−3.656
1.00
19.81
A
C


ATOM
936
CG
GLN
A
80
64.025
−33.857
−5.004
1.00
16.22
A
C


ATOM
939
CD
GLN
A
80
62.628
−34.460
−5.034
1.00
23.03
A
C


ATOM
940
OE1
GLN
A
80
61.984
−34.492
−6.087
1.00
19.49
A
O


ATOM
941
NE2
GLN
A
80
62.146
−34.930
−3.873
1.00
19.16
A
N


ATOM
944
C
GLN
A
80
65.829
−31.542
−2.465
1.00
22.00
A
C


ATOM
945
O
GLN
A
80
65.497
−30.360
−2.366
1.00
25.58
A
O


ATOM
947
N
ARG
A
81
66.399
−32.200
−1.475
1.00
20.76
A
N


ATOM
948
CA
ARG
A
81
66.557
−31.579
−0.171
1.00
22.60
A
C


ATOM
950
CB
ARG
A
81
67.004
−32.619
0.840
1.00
22.73
A
C


ATOM
953
CG
ARG
A
81
65.896
−33.644
1.107
1.00
27.58
A
C


ATOM
956
CD
ARG
A
81
66.200
−34.449
2.360
1.00
26.39
A
C


ATOM
959
NE
ARG
A
81
66.352
−33.563
3.508
1.00
33.93
A
N


ATOM
961
CZ
ARG
A
81
66.523
−33.991
4.754
1.00
44.75
A
C


ATOM
962
NH1
ARG
A
81
66.529
−35.296
5.011
1.00
46.21
A
N


ATOM
965
NH2
ARG
A
81
66.665
−33.114
5.747
1.00
38.64
A
N


ATOM
968
C
ARG
A
81
67.534
−30.418
−0.225
1.00
21.64
A
C


ATOM
969
O
ARG
A
81
67.329
−29.389
0.424
1.00
22.17
A
O


ATOM
971
N
LEU
A
82
68.575
−30.578
−1.032
1.00
18.90
A
N


ATOM
972
CA
LEU
A
82
69.556
−29.522
−1.230
1.00
16.62
A
C


ATOM
974
CB
LEU
A
82
70.796
−30.076
−1.937
1.00
15.07
A
C


ATOM
977
CG
LEU
A
82
71.610
−31.097
−1.137
1.00
19.59
A
C


ATOM
979
CD1
LEU
A
82
72.585
−31.806
−2.061
1.00
19.94
A
C


ATOM
983
CD2
LEU
A
82
72.325
−30.424
0.043
1.00
16.09
A
C


ATOM
987
C
LEU
A
82
68.998
−28.356
−2.013
1.00
17.05
A
C


ATOM
988
O
LEU
A
82
69.691
−27.374
−2.197
1.00
18.11
A
O


ATOM
990
N
GLY
A
83
67.759
−28.470
−2.490
1.00
19.79
A
N


ATOM
991
CA
GLY
A
83
67.064
−27.359
−3.130
1.00
20.72
A
C


ATOM
994
C
GLY
A
83
67.100
−27.353
−4.651
1.00
21.28
A
C


ATOM
995
O
GLY
A
83
66.622
−26.412
−5.277
1.00
21.81
A
O


ATOM
997
N
LEU
A
84
67.620
−28.418
−5.254
1.00
22.14
A
N


ATOM
998
CA
LEU
A
84
67.836
−28.450
−6.704
1.00
22.65
A
C


ATOM
1000
CB
LEU
A
84
69.193
−29.092
−6.998
1.00
20.71
A
C


ATOM
1003
CG
LEU
A
84
70.398
−28.272
−6.564
1.00
21.65
A
C


ATOM
1005
CD1
LEU
A
84
71.625
−29.158
−6.493
1.00
18.26
A
C


ATOM
1009
CD2
LEU
A
84
70.634
−27.090
−7.483
1.00
14.55
A
C


ATOM
1013
C
LEU
A
84
66.744
−29.200
−7.505
1.00
24.69
A
C


ATOM
1014
O
LEU
A
84
66.853
−29.305
−8.734
1.00
24.25
A
O


ATOM
1016
N
GLY
A
85
65.718
−29.718
−6.826
1.00
23.20
A
N


ATOM
1017
CA
GLY
A
85
64.646
−30.512
−7.476
1.00
24.92
A
C


ATOM
1020
C
GLY
A
85
63.962
−29.846
−8.659
1.00
24.61
A
C


ATOM
1021
O
GLY
A
85
63.792
−30.465
−9.714
1.00
26.70
A
O


ATOM
1023
N
TYR
A
86
63.625
−28.570
−8.511
1.00
26.13
A
N


ATOM
1024
CA
TYR
A
86
63.032
−27.765
−9.616
1.00
27.13
A
C


ATOM
1026
CB
TYR
A
86
62.880
−26.295
−9.195
1.00
25.38
A
C


ATOM
1029
CG
TYR
A
86
64.180
−25.458
−9.276
1.00
21.72
A
C


ATOM
1030
CD1
TYR
A
86
64.428
−24.637
−10.362
1.00
19.43
A
C


ATOM
1032
CE1
TYR
A
86
65.582
−23.874
−10.435
1.00
24.50
A
C


ATOM
1034
CZ
TYR
A
86
66.513
−23.916
−9.398
1.00
20.21
A
C


ATOM
1035
OH
TYR
A
86
67.655
−23.164
−9.489
1.00
16.34
A
O


ATOM
1037
CE2
TYR
A
86
66.287
−24.695
−8.297
1.00
15.09
A
C


ATOM
1039
CD2
TYR
A
86
65.123
−25.470
−8.235
1.00
20.89
A
C


ATOM
1041
C
TYR
A
86
63.861
−27.803
−10.904
1.00
28.47
A
C


ATOM
1042
O
TYR
A
86
63.369
−27.573
−12.003
1.00
33.02
A
O


ATOM
1044
N
ARG
A
87
65.140
−28.075
−10.752
1.00
28.58
A
N


ATOM
1045
CA
ARG
A
87
66.067
−28.023
−11.854
1.00
28.18
A
C


ATOM
1047
CB
ARG
A
87
67.395
−27.694
−11.215
1.00
29.83
A
C


ATOM
1050
CG
ARG
A
87
68.405
−27.210
−12.098
1.00
31.31
A
C


ATOM
1053
CD
ARG
A
87
69.334
−26.189
−11.405
1.00
29.77
A
C


ATOM
1056
NE
ARG
A
87
69.857
−25.501
−12.548
1.00
28.60
A
N


ATOM
1058
CZ
ARG
A
87
69.522
−24.301
−12.934
1.00
21.90
A
C


ATOM
1059
NH1
ARG
A
87
70.033
−23.874
−14.064
1.00
36.21
A
N


ATOM
1062
NH2
ARG
A
87
68.772
−23.510
−12.182
1.00
22.93
A
N


ATOM
1065
C
ARG
A
87
66.115
−29.349
−12.639
1.00
27.31
A
C


ATOM
1066
O
ARG
A
87
66.425
−29.375
−13.824
1.00
27.32
A
O


ATOM
1068
N
PHE
A
88
65.773
−30.448
−11.982
1.00
26.33
A
N


ATOM
1069
CA
PHE
A
88
65.973
−31.773
−12.557
1.00
26.77
A
C


ATOM
1071
CB
PHE
A
88
66.993
−32.547
−11.717
1.00
24.89
A
C


ATOM
1074
CG
PHE
A
88
68.349
−31.933
−11.722
1.00
24.57
A
C


ATOM
1075
CD1
PHE
A
88
69.151
−32.027
−12.851
1.00
22.34
A
C


ATOM
1077
CE1
PHE
A
88
70.407
−31.449
−12.879
1.00
24.25
A
C


ATOM
1079
CZ
PHE
A
88
70.870
−30.733
−11.773
1.00
24.17
A
C


ATOM
1081
CE2
PHE
A
88
70.069
−30.614
−10.653
1.00
22.88
A
C


ATOM
1083
CD2
PHE
A
88
68.808
−31.217
−10.629
1.00
21.57
A
C


ATOM
1085
C
PHE
A
88
64.687
−32.558
−12.629
1.00
27.69
A
C


ATOM
1086
O
PHE
A
88
64.708
−33.773
−12.532
1.00
28.94
A
O


ATOM
1088
N
GLU
A
89
63.571
−31.870
−12.834
1.00
29.75
A
N


ATOM
1089
CA
GLU
A
89
62.274
−32.508
−12.692
1.00
32.99
A
C


ATOM
1091
CB
GLU
A
89
61.102
−31.513
−12.765
1.00
33.37
A
C


ATOM
1094
CG
GLU
A
89
59.763
−32.231
−12.470
1.00
46.55
A
C


ATOM
1097
CD
GLU
A
89
58.580
−31.316
−12.217
1.00
57.05
A
C


ATOM
1098
OE1
GLU
A
89
58.729
−30.328
−11.448
1.00
60.68
A
O


ATOM
1099
OE2
GLU
A
89
57.496
−31.622
−12.775
1.00
57.95
A
O


ATOM
1100
C
GLU
A
89
62.042
−33.637
−13.678
1.00
32.53
A
C


ATOM
1101
O
GLU
A
89
61.662
−34.736
−13.269
1.00
32.44
A
O


ATOM
1103
N
SER
A
90
62.244
−33.379
−14.965
1.00
31.61
A
N


ATOM
1104
CA
SER
A
90
62.011
−34.420
−15.965
1.00
32.03
A
C


ATOM
1106
CB
SER
A
90
62.136
−33.884
−17.397
1.00
32.86
A
C


ATOM
1109
OG
SER
A
90
63.207
−32.968
−17.531
1.00
41.77
A
O


ATOM
1111
C
SER
A
90
62.947
−35.591
−15.756
1.00
29.81
A
C


ATOM
1112
O
SER
A
90
62.586
−36.718
−16.032
1.00
31.36
A
O


ATOM
1114
N
ASP
A
91
64.154
−35.326
−15.256
1.00
28.19
A
N


ATOM
1115
CA
ASP
A
91
65.126
−36.396
−15.014
1.00
24.23
A
C


ATOM
1117
CB
ASP
A
91
66.521
−35.807
−14.750
1.00
23.78
A
C


ATOM
1120
CG
ASP
A
91
66.966
−34.819
−15.851
1.00
27.08
A
C


ATOM
1121
OD1
ASP
A
91
67.311
−35.261
−16.954
1.00
33.39
A
O


ATOM
1122
OD2
ASP
A
91
66.968
−33.601
−15.619
1.00
36.51
A
O


ATOM
1123
C
ASP
A
91
64.657
−37.237
−13.820
1.00
25.06
A
C


ATOM
1124
O
ASP
A
91
64.691
−38.467
−13.864
1.00
22.54
A
O


ATOM
1126
N
ILE
A
92
64.213
−36.573
−12.749
1.00
22.98
A
N


ATOM
1127
CA
ILE
A
92
63.739
−37.290
−11.568
1.00
23.78
A
C


ATOM
1129
CB
ILE
A
92
63.401
−36.337
−10.446
1.00
22.94
A
C


ATOM
1131
CG1
ILE
A
92
64.687
−35.861
−9.804
1.00
19.21
A
C


ATOM
1134
CD1
ILE
A
92
64.563
−34.555
−9.062
1.00
17.83
A
C


ATOM
1138
CG2
ILE
A
92
62.526
−37.040
−9.414
1.00
23.71
A
C


ATOM
1142
C
ILE
A
92
62.509
−38.135
−11.919
1.00
24.89
A
C


ATOM
1143
O
ILE
A
92
62.486
−39.327
−11.669
1.00
23.25
A
O


ATOM
1145
N
ARG
A
93
61.513
−37.524
−12.542
1.00
26.25
A
N


ATOM
1146
CA
ARG
A
93
60.331
−38.275
−12.964
1.00
28.67
A
C


ATOM
1148
CB
ARG
A
93
59.345
−37.394
−13.747
1.00
30.12
A
C


ATOM
1151
CG
ARG
A
93
58.786
−36.167
−13.040
1.00
34.31
A
C


ATOM
1154
CD
ARG
A
93
57.781
−35.434
−14.024
1.00
38.26
A
C


ATOM
1157
NE
ARG
A
93
56.850
−36.429
−14.548
1.00
40.69
A
N


ATOM
1159
CZ
ARG
A
93
55.847
−36.955
−13.847
1.00
45.91
A
C


ATOM
1160
NH1
ARG
A
93
55.602
−36.551
−12.602
1.00
47.58
A
N


ATOM
1163
NH2
ARG
A
93
55.059
−37.874
−14.392
1.00
49.96
A
N


ATOM
1166
C
ARG
A
93
60.712
−39.443
−13.877
1.00
28.48
A
C


ATOM
1167
O
ARG
A
93
60.134
−40.512
−13.783
1.00
28.33
A
O


ATOM
1169
N
GLY
A
94
61.655
−39.219
−14.790
1.00
27.77
A
N


ATOM
1170
CA
GLY
A
94
62.097
−40.281
−15.692
1.00
26.95
A
C


ATOM
1173
C
GLY
A
94
62.607
−41.477
−14.914
1.00
28.30
A
C


ATOM
1174
O
GLY
A
94
62.298
−42.631
−15.231
1.00
30.24
A
O


ATOM
1176
N
ALA
A
95
63.390
−41.203
−13.882
1.00
25.47
A
N


ATOM
1177
CA
ALA
A
95
64.045
−42.254
−13.123
1.00
25.65
A
C


ATOM
1179
CB
ALA
A
95
65.183
−41.658
−12.263
1.00
23.46
A
C


ATOM
1183
C
ALA
A
95
63.044
−42.991
−12.250
1.00
25.68
A
C


ATOM
1184
O
ALA
A
95
63.149
−44.208
−12.070
1.00
27.08
A
O


ATOM
1186
N
LEU
A
96
62.073
−42.266
−11.711
1.00
24.42
A
N


ATOM
1187
CA
LEU
A
96
61.032
−42.899
−10.893
1.00
25.56
A
C


ATOM
1189
CB
LEU
A
96
60.201
−41.851
−10.150
1.00
24.25
A
C


ATOM
1192
CG
LEU
A
96
60.979
−41.085
−9.090
1.00
26.81
A
C


ATOM
1194
CD1
LEU
A
96
60.175
−39.926
−8.563
1.00
21.85
A
C


ATOM
1198
CD2
LEU
A
96
61.365
−42.017
−7.974
1.00
23.10
A
C


ATOM
1202
C
LEU
A
96
60.121
−43.764
−11.755
1.00
27.28
A
C


ATOM
1203
O
LEU
A
96
59.707
−44.848
−11.352
1.00
24.29
A
O


ATOM
1205
N
ASP
A
97
59.805
−43.278
−12.952
1.00
31.37
A
N


ATOM
1206
CA
ASP
A
97
59.040
−44.080
−13.895
1.00
34.30
A
C


ATOM
1208
CB
ASP
A
97
58.875
−43.351
−15.205
1.00
34.30
A
C


ATOM
1211
CG
ASP
A
97
57.901
−44.050
−16.125
1.00
47.50
A
C


ATOM
1212
OD1
ASP
A
97
58.360
−44.783
−17.041
1.00
55.79
A
O


ATOM
1213
OD2
ASP
A
97
56.676
−43.884
−15.908
1.00
54.69
A
O


ATOM
1214
C
ASP
A
97
59.735
−45.428
−14.131
1.00
35.14
A
C


ATOM
1215
O
ASP
A
97
59.110
−46.485
−14.136
1.00
34.56
A
O


ATOM
1217
N
ARG
A
98
61.043
−45.376
−14.299
1.00
36.78
A
N


ATOM
1218
CA
ARG
A
98
61.813
−46.568
−14.600
1.00
38.34
A
C


ATOM
1220
CB
ARG
A
98
63.232
−46.187
−15.013
1.00
38.88
A
C


ATOM
1223
CG
ARG
A
98
63.620
−46.641
−16.400
1.00
43.64
A
C


ATOM
1226
CD
ARG
A
98
64.485
−45.611
−17.145
1.00
43.57
A
C


ATOM
1229
NE
ARG
A
98
65.396
−44.847
−16.278
1.00
39.48
A
N


ATOM
1231
CZ
ARG
A
98
65.577
−43.522
−16.340
1.00
34.93
A
C


ATOM
1232
NH1
ARG
A
98
64.927
−42.778
−17.238
1.00
36.94
A
N


ATOM
1235
NH2
ARG
A
98
66.431
−42.932
−15.512
1.00
36.51
A
N


ATOM
1238
C
ARG
A
98
61.842
−47.475
−13.379
1.00
37.58
A
C


ATOM
1239
O
ARG
A
98
61.787
−48.692
−13.519
1.00
38.96
A
O


ATOM
1241
N
PHE
A
99
61.928
−46.879
−12.192
1.00
35.87
A
N


ATOM
1242
CA
PHE
A
99
61.924
−47.629
−10.948
1.00
36.10
A
C


ATOM
1244
CB
PHE
A
99
62.170
−46.693
−9.756
1.00
37.12
A
C


ATOM
1247
CG
PHE
A
99
62.224
−47.401
−8.427
1.00
34.31
A
C


ATOM
1248
CD1
PHE
A
99
63.223
−48.307
−8.162
1.00
37.07
A
C


ATOM
1250
CE1
PHE
A
99
63.275
−48.973
−6.943
1.00
37.15
A
C


ATOM
1252
CZ
PHE
A
99
62.322
−48.714
−5.970
1.00
35.62
A
C


ATOM
1254
CE2
PHE
A
99
61.329
−47.799
−6.221
1.00
30.23
A
C


ATOM
1256
CD2
PHE
A
99
61.271
−47.153
−7.444
1.00
34.40
A
C


ATOM
1258
C
PHE
A
99
60.614
−48.406
−10.759
1.00
36.72
A
C


ATOM
1259
O
PHE
A
99
60.617
−49.513
−10.213
1.00
37.39
A
O


ATOM
1261
N
VAL
A
100
59.502
−47.838
−11.202
1.00
35.36
A
N


ATOM
1262
CA
VAL
A
100
58.258
−48.570
−11.191
1.00
38.56
A
C


ATOM
1264
CB
VAL
A
100
57.054
−47.635
−11.263
1.00
40.72
A
C


ATOM
1266
CG1
VAL
A
100
55.755
−48.457
−11.465
1.00
37.62
A
C


ATOM
1270
CG2
VAL
A
100
56.985
−46.787
−9.999
1.00
33.69
A
C


ATOM
1274
C
VAL
A
100
58.202
−49.563
−12.367
1.00
41.18
A
C


ATOM
1275
O
VAL
A
100
57.974
−50.760
−12.164
1.00
40.05
A
O


ATOM
1277
N
SER
A
101
58.437
−49.072
−13.585
1.00
42.95
A
N


ATOM
1278
CA
SER
A
101
58.207
−49.880
−14.799
1.00
45.08
A
C


ATOM
1280
CB
SER
A
101
58.507
−49.087
−16.079
1.00
46.29
A
C


ATOM
1283
OG
SER
A
101
59.856
−49.282
−16.492
1.00
50.51
A
O


ATOM
1285
C
SER
A
101
59.010
−51.169
−14.802
1.00
44.71
A
C


ATOM
1286
O
SER
A
101
58.550
−52.167
−15.313
1.00
46.34
A
O


ATOM
1288
N
SER
A
102
60.200
−51.136
−14.218
1.00
44.39
A
N


ATOM
1289
CA
SER
A
102
61.053
−52.306
−14.113
1.00
45.16
A
C


ATOM
1291
CB
SER
A
102
62.506
−51.847
−13.944
1.00
46.36
A
C


ATOM
1294
OG
SER
A
102
62.747
−51.406
−12.615
1.00
47.55
A
O


ATOM
1296
C
SER
A
102
60.712
−53.225
−12.925
1.00
45.37
A
C


ATOM
1297
O
SER
A
102
61.418
−54.185
−12.672
1.00
44.04
A
O


ATOM
1299
N
GLY
A
103
59.669
−52.904
−12.167
1.00
46.21
A
N


ATOM
1300
CA
GLY
A
103
59.343
−53.663
−10.955
1.00
46.61
A
C


ATOM
1303
C
GLY
A
103
60.241
−53.437
−9.745
1.00
45.81
A
C


ATOM
1304
O
GLY
A
103
60.133
−54.155
−8.747
1.00
46.61
A
O


ATOM
1306
N
GLY
A
104
61.123
−52.444
−9.817
1.00
45.47
A
N


ATOM
1307
CA
GLY
A
104
62.011
−52.136
−8.702
1.00
44.33
A
C


ATOM
1310
C
GLY
A
104
61.271
−51.766
−7.434
1.00
42.90
A
C


ATOM
1311
O
GLY
A
104
61.640
−52.210
−6.339
1.00
43.32
A
O


ATOM
1313
N
PHE
A
105
60.228
−50.955
−7.574
1.00
41.44
A
N


ATOM
1314
CA
PHE
A
105
59.401
−50.578
−6.426
1.00
42.25
A
C


ATOM
1316
CB
PHE
A
105
58.309
−49.569
−6.800
1.00
40.65
A
C


ATOM
1319
CG
PHE
A
105
57.434
−49.159
−5.634
1.00
39.69
A
C


ATOM
1320
CD1
PHE
A
105
57.991
−48.615
−4.485
1.00
35.48
A
C


ATOM
1322
CE1
PHE
A
105
57.189
−48.232
−3.411
1.00
38.34
A
C


ATOM
1324
CZ
PHE
A
105
55.816
−48.397
−3.486
1.00
41.55
A
C


ATOM
1326
CE2
PHE
A
105
55.253
−48.938
−4.612
1.00
38.70
A
C


ATOM
1328
CD2
PHE
A
105
56.058
−49.308
−5.687
1.00
42.66
A
C


ATOM
1330
C
PHE
A
105
58.765
−51.800
−5.799
1.00
43.53
A
C


ATOM
1331
O
PHE
A
105
58.700
−51.904
−4.584
1.00
42.87
A
O


ATOM
1333
N
ASP
A
106
58.297
−52.729
−6.623
1.00
46.74
A
N


ATOM
1334
CA
ASP
A
106
57.714
−53.948
−6.093
1.00
49.25
A
C


ATOM
1336
CB
ASP
A
106
57.058
−54.776
−7.199
1.00
52.47
A
C


ATOM
1339
CG
ASP
A
106
55.671
−55.256
−6.807
1.00
60.96
A
C


ATOM
1340
OD1
ASP
A
106
54.826
−54.386
−6.468
1.00
69.59
A
O


ATOM
1341
OD2
ASP
A
106
55.436
−56.486
−6.828
1.00
66.22
A
O


ATOM
1342
C
ASP
A
106
58.775
−54.756
−5.354
1.00
48.33
A
C


ATOM
1343
O
ASP
A
106
58.521
−55.290
−4.271
1.00
48.27
A
O


ATOM
1345
N
ALA
A
107
59.971
−54.821
−5.927
1.00
46.84
A
N


ATOM
1346
CA
ALA
A
107
61.096
−55.440
−5.246
1.00
45.49
A
C


ATOM
1348
CB
ALA
A
107
62.380
−55.283
−6.070
1.00
46.29
A
C


ATOM
1352
C
ALA
A
107
61.285
−54.846
−3.853
1.00
44.32
A
C


ATOM
1353
O
ALA
A
107
61.248
−55.581
−2.861
1.00
45.24
A
O


ATOM
1355
N
VAL
A
108
61.468
−53.527
−3.752
1.00
42.93
A
N


ATOM
1356
CA
VAL
A
108
61.877
−52.954
−2.458
1.00
40.66
A
C


ATOM
1358
CB
VAL
A
108
62.288
−51.469
−2.511
1.00
41.66
A
C


ATOM
1360
CG1
VAL
A
108
63.411
−51.263
−3.531
1.00
48.84
A
C


ATOM
1364
CG2
VAL
A
108
61.078
−50.566
−2.778
1.00
34.77
A
C


ATOM
1368
C
VAL
A
108
60.835
−53.130
−1.373
1.00
39.03
A
C


ATOM
1369
O
VAL
A
108
61.198
−53.207
−0.210
1.00
38.61
A
O


ATOM
1371
N
THR
A
109
59.558
−53.220
−1.739
1.00
39.24
A
N


ATOM
1372
CA
THR
A
109
58.504
−53.460
−0.747
1.00
40.61
A
C


ATOM
1374
CB
THR
A
109
57.078
−53.384
−1.330
1.00
40.51
A
C


ATOM
1376
OG1
THR
A
109
56.840
−54.523
−2.162
1.00
40.09
A
O


ATOM
1378
CG2
THR
A
109
56.853
−52.075
−2.115
1.00
38.58
A
C


ATOM
1382
C
THR
A
109
58.656
−54.815
−0.042
1.00
42.53
A
C


ATOM
1383
O
THR
A
109
58.130
−54.999
1.061
1.00
42.34
A
O


ATOM
1385
N
LYS
A
110
59.365
−55.751
−0.673
1.00
44.78
A
N


ATOM
1386
CA
LYS
A
110
59.616
−57.080
−0.082
1.00
47.15
A
C


ATOM
1388
CB
LYS
A
110
59.788
−58.164
−1.164
1.00
48.00
A
C


ATOM
1391
CG
LYS
A
110
58.761
−58.189
−2.295
1.00
52.11
A
C


ATOM
1394
CD
LYS
A
110
57.351
−58.484
−1.819
1.00
60.28
A
C


ATOM
1397
CE
LYS
A
110
56.382
−58.578
−3.010
1.00
65.15
A
C


ATOM
1400
NZ
LYS
A
110
55.021
−58.046
−2.683
1.00
64.69
A
N


ATOM
1404
C
LYS
A
110
60.873
−57.096
0.778
1.00
46.28
A
C


ATOM
1405
O
LYS
A
110
61.028
−57.984
1.603
1.00
47.54
A
O


ATOM
1407
N
THR
A
111
61.770
−56.131
0.570
1.00
46.36
A
N


ATOM
1408
CA
THR
A
111
63.123
−56.191
1.133
1.00
45.50
A
C


ATOM
1410
CB
THR
A
111
64.197
−56.315
0.003
1.00
47.36
A
C


ATOM
1412
OG1
THR
A
111
64.312
−55.076
−0.711
1.00
50.35
A
O


ATOM
1414
CG2
THR
A
111
63.837
−57.451
−1.000
1.00
47.26
A
C


ATOM
1418
C
THR
A
111
63.530
−55.041
2.061
1.00
44.00
A
C


ATOM
1419
O
THR
A
111
64.272
−55.284
3.019
1.00
44.86
A
O


ATOM
1421
N
SER
A
112
63.078
−53.806
1.798
1.00
40.92
A
N


ATOM
1422
CA
SER
A
112
63.645
−52.611
2.480
1.00
37.38
A
C


ATOM
1424
CB
SER
A
112
64.723
−51.988
1.578
1.00
38.61
A
C


ATOM
1427
OG
SER
A
112
65.350
−50.861
2.173
1.00
42.50
A
O


ATOM
1429
C
SER
A
112
62.600
−51.542
2.889
1.00
33.43
A
C


ATOM
1430
O
SER
A
112
61.986
−50.896
2.037
1.00
31.07
A
O


ATOM
1432
N
LEU
A
113
62.399
−51.372
4.194
1.00
29.38
A
N


ATOM
1433
CA
LEU
A
113
61.529
−50.323
4.709
1.00
29.45
A
C


ATOM
1435
CB
LEU
A
113
61.443
−50.353
6.241
1.00
29.86
A
C


ATOM
1438
CG
LEU
A
113
60.553
−49.263
6.868
1.00
31.38
A
C


ATOM
1440
CD1
LEU
A
113
59.109
−49.437
6.427
1.00
29.65
A
C


ATOM
1444
CD2
LEU
A
113
60.631
−49.299
8.378
1.00
33.60
A
C


ATOM
1448
C
LEU
A
113
62.017
−48.954
4.268
1.00
28.16
A
C


ATOM
1449
O
LEU
A
113
61.237
−48.138
3.810
1.00
29.40
A
O


ATOM
1451
N
HIS
A
114
63.308
−48.706
4.417
1.00
27.25
A
N


ATOM
1452
CA
HIS
A
114
63.902
−47.461
3.960
1.00
28.38
A
C


ATOM
1454
CB
HIS
A
114
65.418
−47.448
4.175
1.00
29.85
A
C


ATOM
1457
CG
HIS
A
114
66.073
−46.214
3.663
1.00
29.52
A
C


ATOM
1458
ND1
HIS
A
114
65.529
−44.961
3.846
1.00
36.46
A
N


ATOM
1460
CE1
HIS
A
114
66.310
−44.057
3.281
1.00
35.11
A
C


ATOM
1462
NE2
HIS
A
114
67.322
−44.682
2.711
1.00
36.38
A
N


ATOM
1464
CD2
HIS
A
114
67.197
−46.033
2.937
1.00
36.40
A
C


ATOM
1466
C
HIS
A
114
63.595
−47.220
2.493
1.00
27.08
A
C


ATOM
1467
O
HIS
A
114
63.089
−46.166
2.127
1.00
25.36
A
O


ATOM
1469
N
GLY
A
115
63.884
−48.214
1.665
1.00
27.32
A
N


ATOM
1470
CA
GLY
A
115
63.647
−48.120
0.234
1.00
25.75
A
C


ATOM
1473
C
GLY
A
115
62.184
−47.904
−0.102
1.00
26.39
A
C


ATOM
1474
O
GLY
A
115
61.858
−47.150
−1.041
1.00
26.71
A
O


ATOM
1476
N
THR
A
116
61.306
−48.567
0.657
1.00
24.29
A
N


ATOM
1477
CA
THR
A
116
59.865
−48.470
0.431
1.00
24.57
A
C


ATOM
1479
CB
THR
A
116
59.111
−49.555
1.168
1.00
25.44
A
C


ATOM
1481
OG1
THR
A
116
59.620
−50.825
0.738
1.00
27.83
A
O


ATOM
1483
CG2
THR
A
116
57.589
−49.476
0.868
1.00
20.09
A
C


ATOM
1487
C
THR
A
116
59.307
−47.113
0.832
1.00
25.48
A
C


ATOM
1488
O
THR
A
116
58.594
−46.491
0.046
1.00
25.53
A
O


ATOM
1490
N
ALA
A
117
59.659
−46.647
2.028
1.00
23.44
A
N


ATOM
1491
CA
ALA
A
117
59.194
−45.356
2.505
1.00
24.19
A
C


ATOM
1493
CB
ALA
A
117
59.478
−45.193
4.016
1.00
23.46
A
C


ATOM
1497
C
ALA
A
117
59.791
−44.201
1.699
1.00
24.21
A
C


ATOM
1498
O
ALA
A
117
59.112
−43.225
1.436
1.00
23.16
A
O


ATOM
1500
N
LEU
A
118
61.048
−44.301
1.286
1.00
24.65
A
N


ATOM
1501
CA
LEU
A
118
61.631
−43.222
0.443
1.00
25.43
A
C


ATOM
1503
CB
LEU
A
118
63.157
−43.356
0.339
1.00
24.64
A
C


ATOM
1506
CG
LEU
A
118
63.924
−42.343
−0.519
1.00
29.58
A
C


ATOM
1508
CD1
LEU
A
118
63.697
−40.923
−0.069
1.00
22.30
A
C


ATOM
1512
CD2
LEU
A
118
65.403
−42.690
−0.477
1.00
24.34
A
C


ATOM
1516
C
LEU
A
118
60.986
−43.203
−0.936
1.00
24.40
A
C


ATOM
1517
O
LEU
A
118
60.497
−42.172
−1.409
1.00
24.21
A
O


ATOM
1519
N
SER
A
119
60.943
−44.362
−1.580
1.00
25.13
A
N


ATOM
1520
CA
SER
A
119
60.368
−44.416
−2.916
1.00
23.95
A
C


ATOM
1522
CB
SER
A
119
60.589
−45.779
−3.563
1.00
25.32
A
C


ATOM
1525
OG
SER
A
119
59.934
−46.812
−2.867
1.00
26.72
A
O


ATOM
1527
C
SER
A
119
58.892
−44.054
−2.902
1.00
23.29
A
C


ATOM
1528
O
SER
A
119
58.429
−43.326
−3.770
1.00
23.89
A
O


ATOM
1530
N
PHE
A
120
58.162
−44.537
−1.903
1.00
22.65
A
N


ATOM
1531
CA
PHE
A
120
56.760
−44.152
−1.715
1.00
22.34
A
C


ATOM
1533
CB
PHE
A
120
56.202
−44.766
−0.422
1.00
22.44
A
C


ATOM
1536
CG
PHE
A
120
54.758
−44.427
−0.154
1.00
23.67
A
C


ATOM
1537
CD1
PHE
A
120
53.752
−45.312
−0.480
1.00
26.16
A
C


ATOM
1539
CE1
PHE
A
120
52.413
−45.001
−0.220
1.00
26.81
A
C


ATOM
1541
CZ
PHE
A
120
52.092
−43.791
0.378
1.00
23.94
A
C


ATOM
1543
CE2
PHE
A
120
53.089
−42.932
0.722
1.00
23.73
A
C


ATOM
1545
CD2
PHE
A
120
54.414
−43.240
0.454
1.00
25.92
A
C


ATOM
1547
C
PHE
A
120
56.606
−42.630
−1.669
1.00
20.61
A
C


ATOM
1548
O
PHE
A
120
55.759
−42.066
−2.345
1.00
19.01
A
O


ATOM
1550
N
ARG
A
121
57.410
−41.966
−0.850
1.00
19.18
A
N


ATOM
1551
CA
ARG
A
121
57.326
−40.506
−0.775
1.00
20.59
A
C


ATOM
1553
CB
ARG
A
121
58.263
−39.962
0.293
1.00
20.27
A
C


ATOM
1556
CG
ARG
A
121
58.293
−38.443
0.373
1.00
20.89
A
C


ATOM
1559
CD
ARG
A
121
58.902
−37.979
1.690
1.00
25.20
A
C


ATOM
1562
NE
ARG
A
121
60.315
−38.344
1.819
1.00
23.57
A
N


ATOM
1564
CZ
ARG
A
121
61.313
−37.708
1.209
1.00
23.54
A
C


ATOM
1565
NH1
ARG
A
121
61.068
−36.674
0.414
1.00
25.58
A
N


ATOM
1568
NH2
ARG
A
121
62.566
−38.101
1.399
1.00
26.88
A
N


ATOM
1571
C
ARG
A
121
57.648
−39.851
−2.127
1.00
19.48
A
C


ATOM
1572
O
ARG
A
121
56.909
−38.997
−2.609
1.00
19.29
A
O


ATOM
1574
N
LEU
A
122
58.759
−40.238
−2.730
1.00
18.56
A
N


ATOM
1575
CA
LEU
A
122
59.159
−39.613
−4.017
1.00
20.57
A
C


ATOM
1577
CB
LEU
A
122
60.537
−40.098
−4.452
1.00
18.26
A
C


ATOM
1580
CG
LEU
A
122
61.666
−39.788
−3.466
1.00
21.60
A
C


ATOM
1582
CD1
LEU
A
122
62.946
−40.470
−3.896
1.00
21.70
A
C


ATOM
1586
CD2
LEU
A
122
61.855
−38.314
−3.393
1.00
16.48
A
C


ATOM
1590
C
LEU
A
122
58.121
−39.881
−5.129
1.00
20.63
A
C


ATOM
1591
O
LEU
A
122
57.780
−39.002
−5.914
1.00
21.52
A
O


ATOM
1593
N
LEU
A
123
57.594
−41.088
−5.167
1.00
20.62
A
N


ATOM
1594
CA
LEU
A
123
56.623
−41.439
−6.195
1.00
20.75
A
C


ATOM
1596
CB
LEU
A
123
56.330
−42.919
−6.128
1.00
20.28
A
C


ATOM
1599
CG
LEU
A
123
57.412
−43.829
−6.735
1.00
22.58
A
C


ATOM
1601
CD1
LEU
A
123
57.134
−45.289
−6.354
1.00
20.41
A
C


ATOM
1605
CD2
LEU
A
123
57.468
−43.716
−8.242
1.00
19.56
A
C


ATOM
1609
C
LEU
A
123
55.345
−40.604
−6.046
1.00
21.54
A
C


ATOM
1610
O
LEU
A
123
54.858
−39.995
−7.011
1.00
20.27
A
O


ATOM
1612
N
ARG
A
124
54.820
−40.534
−4.829
1.00
22.21
A
N


ATOM
1613
CA
ARG
A
124
53.585
−39.797
−4.615
1.00
20.97
A
C


ATOM
1615
CB
ARG
A
124
52.987
−40.096
−3.246
1.00
19.35
A
C


ATOM
1618
CG
ARG
A
124
51.792
−39.228
−2.932
1.00
23.37
A
C


ATOM
1621
CD
ARG
A
124
51.015
−39.762
−1.753
1.00
23.81
A
C


ATOM
1624
NE
ARG
A
124
50.298
−41.008
−2.048
1.00
20.90
A
N


ATOM
1626
CZ
ARG
A
124
49.550
−41.652
−1.158
1.00
23.68
A
C


ATOM
1627
NH1
ARG
A
124
49.450
−41.192
0.085
1.00
19.23
A
N


ATOM
1630
NH2
ARG
A
124
48.900
−42.746
−1.502
1.00
20.41
A
N


ATOM
1633
C
ARG
A
124
53.831
−38.321
−4.814
1.00
18.12
A
C


ATOM
1634
O
ARG
A
124
53.021
−37.627
−5.402
1.00
21.48
A
O


ATOM
1636
N
GLN
A
125
54.959
−37.831
−4.343
1.00
20.20
A
N


ATOM
1637
CA
GLN
A
125
55.321
−36.430
−4.584
1.00
21.03
A
C


ATOM
1639
CB
GLN
A
125
56.744
−36.147
−4.080
1.00
21.65
A
C


ATOM
1642
CG
GLN
A
125
57.280
−34.765
−4.498
1.00
20.36
A
C


ATOM
1645
CD
GLN
A
125
58.726
−34.527
−4.121
1.00
26.60
A
C


ATOM
1646
OE1
GLN
A
125
59.381
−35.390
−3.526
1.00
21.64
A
O


ATOM
1647
NE2
GLN
A
125
59.247
−33.352
−4.492
1.00
18.29
A
N


ATOM
1650
C
GLN
A
125
55.266
−36.089
−6.080
1.00
21.86
A
C


ATOM
1651
O
GLN
A
125
54.826
−34.999
−6.477
1.00
23.50
A
O


ATOM
1653
N
HIS
A
126
55.739
−37.011
−6.912
1.00
22.17
A
N


ATOM
1654
CA
HIS
A
126
55.787
−36.760
−8.350
1.00
23.23
A
C


ATOM
1656
CB
HIS
A
126
57.100
−37.293
−8.904
1.00
23.41
A
C


ATOM
1659
CG
HIS
A
126
58.250
−36.415
−8.563
1.00
20.04
A
C


ATOM
1660
ND1
HIS
A
126
58.516
−35.260
−9.256
1.00
26.32
A
N


ATOM
1662
CE1
HIS
A
126
59.541
−34.646
−8.700
1.00
22.03
A
C


ATOM
1664
NE2
HIS
A
126
59.942
−35.359
−7.667
1.00
19.54
A
N


ATOM
1666
CD2
HIS
A
126
59.139
−36.463
−7.548
1.00
18.20
A
C


ATOM
1668
C
HIS
A
126
54.568
−37.274
−9.096
1.00
25.26
A
C


ATOM
1669
O
HIS
A
126
54.602
−37.438
−10.311
1.00
26.07
A
O


ATOM
1671
N
GLY
A
127
53.479
−37.528
−8.371
1.00
25.78
A
N


ATOM
1672
CA
GLY
A
127
52.198
−37.783
−9.033
1.00
24.01
A
C


ATOM
1675
C
GLY
A
127
51.898
−39.232
−9.348
1.00
23.73
A
C


ATOM
1676
O
GLY
A
127
50.879
−39.513
−9.937
1.00
28.90
A
O


ATOM
1678
N
PHE
A
128
52.763
−40.163
−8.977
1.00
23.33
A
N


ATOM
1679
CA
PHE
A
128
52.490
−41.563
−9.251
1.00
25.32
A
C


ATOM
1681
CB
PHE
A
128
53.775
−42.381
−9.271
1.00
23.93
A
C


ATOM
1684
CG
PHE
A
128
54.725
−42.003
−10.366
1.00
26.62
A
C


ATOM
1685
CD1
PHE
A
128
54.739
−42.698
−11.555
1.00
27.05
A
C


ATOM
1687
CE1
PHE
A
128
55.633
−42.369
−12.551
1.00
30.59
A
C


ATOM
1689
CZ
PHE
A
128
56.513
−41.321
−12.368
1.00
33.45
A
C


ATOM
1691
CE2
PHE
A
128
56.500
−40.627
−11.187
1.00
30.11
A
C


ATOM
1693
CD2
PHE
A
128
55.629
−40.979
−10.194
1.00
25.68
A
C


ATOM
1695
C
PHE
A
128
51.535
−42.136
−8.193
1.00
28.35
A
C


ATOM
1696
O
PHE
A
128
51.473
−41.657
−7.062
1.00
28.35
A
O


ATOM
1698
N
GLU
A
129
50.828
−43.178
−8.584
1.00
30.58
A
N


ATOM
1699
CA
GLU
A
129
49.896
−43.880
−7.739
1.00
33.23
A
C


ATOM
1701
CB
GLU
A
129
48.816
−44.578
−8.589
1.00
34.45
A
C


ATOM
1704
CG
GLU
A
129
47.751
−43.588
−9.137
1.00
47.35
A
C


ATOM
1707
CD
GLU
A
129
46.460
−44.250
−9.690
1.00
59.81
A
C


ATOM
1708
OE1
GLU
A
129
45.701
−43.545
−10.403
1.00
60.68
A
O


ATOM
1709
OE2
GLU
A
129
46.191
−45.448
−9.409
1.00
66.05
A
O


ATOM
1710
C
GLU
A
129
50.630
−44.910
−6.913
1.00
30.73
A
C


ATOM
1711
O
GLU
A
129
51.213
−45.846
−7.455
1.00
30.68
A
O


ATOM
1713
N
VAL
A
130
50.610
−44.735
−5.601
1.00
27.24
A
N


ATOM
1714
CA
VAL
A
130
51.116
−45.775
−4.718
1.00
26.66
A
C


ATOM
1716
CB
VAL
A
130
52.486
−45.414
−4.131
1.00
26.82
A
C


ATOM
1718
CG1
VAL
A
130
53.534
−45.415
−5.233
1.00
26.47
A
C


ATOM
1722
CG2
VAL
A
130
52.439
−44.045
−3.428
1.00
22.87
A
C


ATOM
1726
C
VAL
A
130
50.101
−45.976
−3.618
1.00
25.49
A
C


ATOM
1727
O
VAL
A
130
49.328
−45.069
−3.314
1.00
23.94
A
O


ATOM
1729
N
SER
A
131
50.094
−47.168
−3.035
1.00
25.58
A
N


ATOM
1730
CA
SER
A
131
49.112
−47.518
−2.021
1.00
25.94
A
C


ATOM
1732
CB
SER
A
131
48.356
−48.780
−2.443
1.00
29.50
A
C


ATOM
1735
OG
SER
A
131
47.847
−49.475
−1.304
1.00
28.83
A
O


ATOM
1737
C
SER
A
131
49.764
−47.783
−0.707
1.00
23.83
A
C


ATOM
1738
O
SER
A
131
50.909
−48.214
−0.668
1.00
24.97
A
O


ATOM
1740
N
GLN
A
132
49.015
−47.581
0.375
1.00
24.32
A
N


ATOM
1741
CA
GLN
A
132
49.526
−47.858
1.733
1.00
25.61
A
C


ATOM
1743
CB
GLN
A
132
48.516
−47.393
2.800
1.00
24.08
A
C


ATOM
1746
CG
GLN
A
132
47.161
−48.125
2.806
1.00
27.85
A
C


ATOM
1749
CD
GLN
A
132
46.283
−47.760
4.011
1.00
25.79
A
C


ATOM
1750
OE1
GLN
A
132
46.644
−46.918
4.824
1.00
26.01
A
O


ATOM
1751
NE2
GLN
A
132
45.129
−48.398
4.118
1.00
27.24
A
N


ATOM
1754
C
GLN
A
132
49.904
−49.353
1.924
1.00
26.55
A
C


ATOM
1755
O
GLN
A
132
50.751
−49.702
2.742
1.00
23.45
A
O


ATOM
1757
N
GLU
A
133
49.299
−50.236
1.147
1.00
26.74
A
N


ATOM
1758
CA
GLU
A
133
49.661
−51.643
1.243
1.00
30.43
A
C


ATOM
1760
CB
GLU
A
133
48.627
−52.582
0.584
1.00
31.92
A
C


ATOM
1763
CG
GLU
A
133
48.242
−52.326
−0.834
1.00
41.00
A
C


ATOM
1766
CD
GLU
A
133
46.890
−52.992
−1.251
1.00
47.38
A
C


ATOM
1767
OE1
GLU
A
133
45.793
−52.388
−1.115
1.00
48.99
A
O


ATOM
1768
OE2
GLU
A
133
46.944
−54.114
−1.767
1.00
48.11
A
O


ATOM
1769
C
GLU
A
133
51.104
−51.920
0.816
1.00
30.03
A
C


ATOM
1770
O
GLU
A
133
51.634
−52.980
1.099
1.00
30.56
A
O


ATOM
1772
N
ALA
A
134
51.779
−50.944
0.220
1.00
30.33
A
N


ATOM
1773
CA
ALA
A
134
53.229
−51.050
0.026
1.00
29.74
A
C


ATOM
1775
CB
ALA
A
134
53.759
−49.793
−0.603
1.00
28.04
A
C


ATOM
1779
C
ALA
A
134
53.976
−51.319
1.333
1.00
30.69
A
C


ATOM
1780
O
ALA
A
134
55.073
−51.845
1.323
1.00
31.48
A
O


ATOM
1782
N
PHE
A
135
53.377
−50.946
2.454
1.00
31.85
A
N


ATOM
1783
CA
PHE
A
135
53.987
−51.134
3.762
1.00
31.97
A
C


ATOM
1785
CB
PHE
A
135
53.673
−49.906
4.633
1.00
29.56
A
C


ATOM
1788
CG
PHE
A
135
54.296
−48.619
4.122
1.00
28.98
A
C


ATOM
1789
CD1
PHE
A
135
53.549
−47.697
3.402
1.00
24.38
A
C


ATOM
1791
CE1
PHE
A
135
54.120
−46.519
2.916
1.00
21.90
A
C


ATOM
1793
CZ
PHE
A
135
55.450
−46.254
3.153
1.00
24.74
A
C


ATOM
1795
CE2
PHE
A
135
56.215
−47.169
3.850
1.00
26.09
A
C


ATOM
1797
CD2
PHE
A
135
55.635
−48.350
4.336
1.00
28.54
A
C


ATOM
1799
C
PHE
A
135
53.522
−52.442
4.470
1.00
34.24
A
C


ATOM
1800
O
PHE
A
135
53.953
−52.727
5.590
1.00
33.24
A
O


ATOM
1802
N
SER
A
136
52.667
−53.235
3.825
1.00
35.02
A
N


ATOM
1803
CA
SER
A
136
52.050
−54.394
4.506
1.00
37.80
A
C


ATOM
1805
CB
SER
A
136
50.943
−55.039
3.654
1.00
37.47
A
C


ATOM
1808
OG
SER
A
136
51.480
−55.711
2.531
1.00
37.80
A
O


ATOM
1810
C
SER
A
136
53.065
−55.448
4.966
1.00
38.21
A
C


ATOM
1811
O
SER
A
136
52.917
−56.015
6.045
1.00
40.62
A
O


ATOM
1813
N
GLY
A
137
54.120
−55.662
4.188
1.00
38.95
A
N


ATOM
1814
CA
GLY
A
137
55.167
−56.606
4.562
1.00
38.95
A
C


ATOM
1817
C
GLY
A
137
56.057
−56.211
5.738
1.00
39.26
A
C


ATOM
1818
O
GLY
A
137
57.001
−56.924
6.045
1.00
39.28
A
O


ATOM
1820
N
PHE
A
138
55.770
−55.096
6.405
1.00
39.21
A
N


ATOM
1821
CA
PHE
A
138
56.593
−54.643
7.532
1.00
40.53
A
C


ATOM
1823
CB
PHE
A
138
57.131
−53.223
7.260
1.00
38.00
A
C


ATOM
1826
CG
PHE
A
138
57.991
−53.154
6.039
1.00
34.18
A
C


ATOM
1827
CD1
PHE
A
138
59.251
−53.731
6.040
1.00
34.73
A
C


ATOM
1829
CE1
PHE
A
138
60.049
−53.705
4.893
1.00
34.21
A
C


ATOM
1831
CZ
PHE
A
138
59.572
−53.132
3.736
1.00
30.84
A
C


ATOM
1833
CE2
PHE
A
138
58.307
−52.565
3.720
1.00
32.61
A
C


ATOM
1835
CD2
PHE
A
138
57.522
−52.590
4.867
1.00
33.77
A
C


ATOM
1837
C
PHE
A
138
55.837
−54.727
8.856
1.00
43.36
A
C


ATOM
1838
O
PHE
A
138
56.261
−54.163
9.862
1.00
43.05
A
O


ATOM
1840
N
LYS
A
139
54.727
−55.455
8.852
1.00
47.23
A
N


ATOM
1841
CA
LYS
A
139
53.884
−55.562
10.029
1.00
51.13
A
C


ATOM
1843
CB
LYS
A
139
52.457
−55.086
9.696
1.00
51.78
A
C


ATOM
1846
CG
LYS
A
139
52.392
−53.546
9.534
1.00
54.28
A
C


ATOM
1849
CD
LYS
A
139
51.184
−53.029
8.748
1.00
61.08
A
C


ATOM
1852
CE
LYS
A
139
49.951
−52.824
9.631
1.00
64.23
A
C


ATOM
1855
NZ
LYS
A
139
50.121
−51.700
10.603
1.00
59.56
A
N


ATOM
1859
C
LYS
A
139
53.964
−56.984
10.582
1.00
53.19
A
C


ATOM
1860
O
LYS
A
139
54.306
−57.915
9.856
1.00
54.52
A
O


ATOM
1862
N
ASP
A
140
53.715
−57.124
11.886
1.00
55.49
A
N


ATOM
1863
CA
ASP
A
140
53.821
−58.410
12.591
1.00
56.32
A
C


ATOM
1865
CB
ASP
A
140
54.282
−58.194
14.050
1.00
56.20
A
C


ATOM
1868
CG
ASP
A
140
53.262
−57.437
14.902
1.00
53.48
A
C


ATOM
1869
OD1
ASP
A
140
52.109
−57.244
14.468
1.00
47.36
A
O


ATOM
1870
OD2
ASP
A
140
53.627
−57.019
16.016
1.00
50.19
A
O


ATOM
1871
C
ASP
A
140
52.503
−59.184
12.535
1.00
58.61
A
C


ATOM
1872
O
ASP
A
140
51.591
−58.814
11.787
1.00
57.83
A
O


ATOM
1874
N
GLN
A
141
52.409
−60.260
13.321
1.00
61.75
A
N


ATOM
1875
CA
GLN
A
141
51.191
−61.083
13.382
1.00
63.46
A
C


ATOM
1877
CB
GLN
A
141
51.350
−62.206
14.419
1.00
64.54
A
C


ATOM
1880
CG
GLN
A
141
52.401
−63.260
14.080
1.00
67.62
A
C


ATOM
1883
CD
GLN
A
141
52.236
−64.534
14.912
1.00
71.72
A
C


ATOM
1884
OE1
GLN
A
141
51.201
−65.200
14.845
1.00
71.94
A
O


ATOM
1885
NE2
GLN
A
141
53.256
−64.873
15.698
1.00
69.09
A
N


ATOM
1888
C
GLN
A
141
49.927
−60.264
13.708
1.00
63.18
A
C


ATOM
1889
O
GLN
A
141
48.854
−60.539
13.161
1.00
63.42
A
O


ATOM
1891
N
ASN
A
142
50.071
−59.265
14.585
1.00
62.04
A
N


ATOM
1892
CA
ASN
A
142
48.948
−58.447
15.067
1.00
61.76
A
C


ATOM
1894
CB
ASN
A
142
49.211
−58.041
16.521
1.00
62.74
A
C


ATOM
1897
CG
ASN
A
142
49.124
−59.216
17.476
1.00
64.28
A
C


ATOM
1898
OD1
ASN
A
142
48.147
−59.967
17.461
1.00
65.28
A
O


ATOM
1899
ND2
ASN
A
142
50.143
−59.379
18.314
1.00
61.18
A
N


ATOM
1902
C
ASN
A
142
48.609
−57.182
14.259
1.00
60.73
A
C


ATOM
1903
O
ASN
A
142
47.790
−56.374
14.696
1.00
60.76
A
O


ATOM
1905
N
GLY
A
143
49.223
−57.006
13.094
1.00
58.94
A
N


ATOM
1906
CA
GLY
A
143
48.969
−55.823
12.273
1.00
58.11
A
C


ATOM
1909
C
GLY
A
143
49.577
−54.533
12.818
1.00
56.81
A
C


ATOM
1910
O
GLY
A
143
49.040
−53.451
12.596
1.00
56.75
A
O


ATOM
1912
N
ASN
A
144
50.684
−54.658
13.551
1.00
54.34
A
N


ATOM
1913
CA
ASN
A
144
51.452
−53.517
14.036
1.00
51.31
A
C


ATOM
1915
CB
ASN
A
144
51.523
−53.532
15.561
1.00
50.99
A
C


ATOM
1918
CG
ASN
A
144
50.156
−53.394
16.203
1.00
54.98
A
C


ATOM
1919
OD1
ASN
A
144
49.390
−52.496
15.861
1.00
57.50
A
O


ATOM
1920
ND2
ASN
A
144
49.836
−54.291
17.129
1.00
54.41
A
N


ATOM
1923
C
ASN
A
144
52.842
−53.594
13.421
1.00
47.91
A
C


ATOM
1924
O
ASN
A
144
53.314
−54.678
13.096
1.00
45.74
A
O


ATOM
1926
N
PHE
A
145
53.487
−52.450
13.225
1.00
45.60
A
N


ATOM
1927
CA
PHE
A
145
54.827
−52.432
12.636
1.00
42.79
A
C


ATOM
1929
CB
PHE
A
145
55.315
−50.995
12.429
1.00
41.21
A
C


ATOM
1932
CG
PHE
A
145
54.767
−50.342
11.190
1.00
34.59
A
C


ATOM
1933
CD1
PHE
A
145
53.612
−49.583
11.241
1.00
28.50
A
C


ATOM
1935
CE1
PHE
A
145
53.097
−48.999
10.107
1.00
33.37
A
C


ATOM
1937
CZ
PHE
A
145
53.749
−49.159
8.890
1.00
34.40
A
C


ATOM
1939
CE2
PHE
A
145
54.909
−49.912
8.827
1.00
36.36
A
C


ATOM
1941
CD2
PHE
A
145
55.403
−50.508
9.971
1.00
33.35
A
C


ATOM
1943
C
PHE
A
145
55.811
−53.220
13.509
1.00
43.43
A
C


ATOM
1944
O
PHE
A
145
55.739
−53.168
14.740
1.00
39.77
A
O


ATOM
1946
N
LEU
A
146
56.719
−53.949
12.862
1.00
45.03
A
N


ATOM
1947
CA
LEU
A
146
57.658
−54.811
13.574
1.00
47.52
A
C


ATOM
1949
CB
LEU
A
146
58.571
−55.562
12.600
1.00
48.77
A
C


ATOM
1952
CG
LEU
A
146
57.939
−56.744
11.854
1.00
51.30
A
C


ATOM
1954
CD1
LEU
A
146
58.802
−57.157
10.656
1.00
53.93
A
C


ATOM
1958
CD2
LEU
A
146
57.724
−57.920
12.803
1.00
50.78
A
C


ATOM
1962
C
LEU
A
146
58.503
−53.994
14.521
1.00
47.29
A
C


ATOM
1963
O
LEU
A
146
59.085
−53.004
14.122
1.00
46.58
A
O


ATOM
1965
N
GLU
A
147
58.546
−54.418
15.778
1.00
48.15
A
N


ATOM
1966
CA
GLU
A
147
59.333
−53.766
16.818
1.00
49.25
A
C


ATOM
1968
CB
GLU
A
147
59.243
−54.591
18.121
1.00
51.28
A
C


ATOM
1971
CG
GLU
A
147
59.923
−53.979
19.359
1.00
56.00
A
C


ATOM
1974
CD
GLU
A
147
59.228
−52.725
19.877
1.00
63.07
A
C


ATOM
1975
OE1
GLU
A
147
58.125
−52.395
19.387
1.00
66.00
A
O


ATOM
1976
OE2
GLU
A
147
59.788
−52.068
20.785
1.00
66.72
A
O


ATOM
1977
C
GLU
A
147
60.791
−53.608
16.404
1.00
47.26
A
C


ATOM
1978
O
GLU
A
147
61.365
−52.554
16.584
1.00
46.13
A
O


ATOM
1980
N
ASN
A
148
61.383
−54.649
15.830
1.00
47.30
A
N


ATOM
1981
CA
ASN
A
148
62.824
−54.639
15.564
1.00
48.47
A
C


ATOM
1983
CB
ASN
A
148
63.333
−56.046
15.259
1.00
49.35
A
C


ATOM
1986
CG
ASN
A
148
62.710
−56.636
14.014
1.00
55.86
A
C


ATOM
1987
OD1
ASN
A
148
62.358
−55.913
13.075
1.00
62.15
A
O


ATOM
1988
ND2
ASN
A
148
62.566
−57.959
13.994
1.00
57.68
A
N


ATOM
1991
C
ASN
A
148
63.268
−53.665
14.470
1.00
48.40
A
C


ATOM
1992
O
ASN
A
148
64.470
−53.493
14.255
1.00
48.76
A
O


ATOM
1994
N
LEU
A
149
62.308
−53.037
13.781
1.00
47.17
A
N


ATOM
1995
CA
LEU
A
149
62.612
−52.012
12.775
1.00
45.22
A
C


ATOM
1997
CB
LEU
A
149
61.391
−51.719
11.883
1.00
44.21
A
C


ATOM
2000
CG
LEU
A
149
60.901
−52.874
10.985
1.00
45.00
A
C


ATOM
2002
CD1
LEU
A
149
59.457
−52.641
10.487
1.00
35.64
A
C


ATOM
2006
CD2
LEU
A
149
61.859
−53.134
9.818
1.00
40.71
A
C


ATOM
2010
C
LEU
A
149
63.119
−50.719
13.427
1.00
44.14
A
C


ATOM
2011
O
LEU
A
149
63.767
−49.915
12.767
1.00
43.38
A
O


ATOM
2013
N
LYS
A
150
62.848
−50.535
14.723
1.00
43.89
A
N


ATOM
2014
CA
LYS
A
150
63.299
−49.345
15.459
1.00
43.64
A
C


ATOM
2016
CB
LYS
A
150
62.834
−49.395
16.921
1.00
44.18
A
C


ATOM
2019
CG
LYS
A
150
63.567
−50.438
17.776
1.00
45.80
A
C


ATOM
2022
CD
LYS
A
150
62.990
−50.566
19.179
1.00
46.45
A
C


ATOM
2025
CE
LYS
A
150
63.602
−51.772
19.932
1.00
46.45
A
C


ATOM
2028
NZ
LYS
A
150
63.600
−51.578
21.410
1.00
44.46
A
N


ATOM
2032
C
LYS
A
150
64.816
−49.166
15.418
1.00
43.28
A
C


ATOM
2033
O
LYS
A
150
65.307
−48.058
15.547
1.00
43.46
A
O


ATOM
2035
N
GLU
A
151
65.548
−50.262
15.231
1.00
43.96
A
N


ATOM
2036
CA
GLU
A
151
67.016
−50.229
15.193
1.00
44.86
A
C


ATOM
2038
CB
GLU
A
151
67.590
−51.660
15.231
1.00
46.17
A
C


ATOM
2041
CG
GLU
A
151
67.109
−52.575
16.391
1.00
48.12
A
C


ATOM
2044
CD
GLU
A
151
67.468
−52.062
17.783
1.00
57.25
A
C


ATOM
2045
OE1
GLU
A
151
68.205
−51.057
17.895
1.00
58.32
A
O


ATOM
2046
OE2
GLU
A
151
67.010
−52.679
18.776
1.00
64.54
A
O


ATOM
2047
C
GLU
A
151
67.568
−49.510
13.960
1.00
44.01
A
C


ATOM
2048
O
GLU
A
151
68.687
−49.009
13.987
1.00
45.27
A
O


ATOM
2050
N
ASP
A
152
66.778
−49.481
12.887
1.00
43.54
A
N


ATOM
2051
CA
ASP
A
152
67.182
−48.939
11.586
1.00
42.81
A
C


ATOM
2053
CB
ASP
A
152
66.628
−49.846
10.469
1.00
42.48
A
C


ATOM
2056
CG
ASP
A
152
67.076
−49.431
9.065
1.00
44.12
A
C


ATOM
2057
OD1
ASP
A
152
67.707
−48.356
8.890
1.00
44.74
A
O


ATOM
2058
OD2
ASP
A
152
66.785
−50.208
8.122
1.00
43.55
A
O


ATOM
2059
C
ASP
A
152
66.619
−47.524
11.481
1.00
41.46
A
C


ATOM
2060
O
ASP
A
152
65.557
−47.307
10.902
1.00
41.35
A
O


ATOM
2062
N
ILE
A
153
67.345
−46.569
12.045
1.00
39.78
A
N


ATOM
2063
CA
ILE
A
153
66.816
−45.228
12.270
1.00
39.72
A
C


ATOM
2065
CB
ILE
A
153
67.695
−44.468
13.244
1.00
40.91
A
C


ATOM
2067
CG1
ILE
A
153
67.578
−45.131
14.627
1.00
43.16
A
C


ATOM
2070
CD1
ILE
A
153
68.849
−45.081
15.411
1.00
50.21
A
C


ATOM
2074
CG2
ILE
A
153
67.288
−42.997
13.309
1.00
36.49
A
C


ATOM
2078
C
ILE
A
153
66.625
−44.422
10.992
1.00
39.38
A
C


ATOM
2079
O
ILE
A
153
65.718
−43.606
10.902
1.00
38.41
A
O


ATOM
2081
N
LYS
A
154
67.483
−44.667
10.011
1.00
38.77
A
N


ATOM
2082
CA
LYS
A
154
67.316
−44.131
8.675
1.00
38.08
A
C


ATOM
2084
CB
LYS
A
154
68.439
−44.657
7.771
1.00
39.94
A
C


ATOM
2087
CG
LYS
A
154
69.030
−43.679
6.791
1.00
46.34
A
C


ATOM
2090
CD
LYS
A
154
69.998
−44.418
5.833
1.00
57.75
A
C


ATOM
2093
CE
LYS
A
154
71.163
−43.526
5.362
1.00
63.86
A
C


ATOM
2096
NZ
LYS
A
154
72.090
−43.113
6.477
1.00
66.28
A
N


ATOM
2100
C
LYS
A
154
65.966
−44.582
8.123
1.00
34.45
A
C


ATOM
2101
O
LYS
A
154
65.265
−43.806
7.491
1.00
34.91
A
O


ATOM
2103
N
ALA
A
155
65.602
−45.841
8.360
1.00
31.65
A
N


ATOM
2104
CA
ALA
A
155
64.367
−46.382
7.796
1.00
29.70
A
C


ATOM
2106
CB
ALA
A
155
64.349
−47.881
7.905
1.00
28.03
A
C


ATOM
2110
C
ALA
A
155
63.147
−45.772
8.484
1.00
29.53
A
C


ATOM
2111
O
ALA
A
155
62.118
−45.546
7.862
1.00
28.76
A
O


ATOM
2113
N
ILE
A
156
63.291
−45.483
9.769
1.00
28.30
A
N


ATOM
2114
CA
ILE
A
156
62.218
−44.941
10.574
1.00
29.28
A
C


ATOM
2116
CB
ILE
A
156
62.573
−45.035
12.062
1.00
30.53
A
C


ATOM
2118
CG1
ILE
A
156
62.606
−46.500
12.498
1.00
32.30
A
C


ATOM
2121
CD1
ILE
A
156
61.294
−47.182
12.411
1.00
34.89
A
C


ATOM
2125
CG2
ILE
A
156
61.599
−44.209
12.894
1.00
35.42
A
C


ATOM
2129
C
ILE
A
156
61.957
−43.486
10.232
1.00
26.18
A
C


ATOM
2130
O
ILE
A
156
60.816
−43.061
10.146
1.00
25.91
A
O


ATOM
2132
N
LEU
A
157
63.026
−42.738
10.049
1.00
25.45
A
N


ATOM
2133
CA
LEU
A
157
62.941
−41.363
9.595
1.00
27.66
A
C


ATOM
2135
CB
LEU
A
157
64.320
−40.773
9.381
1.00
28.15
A
C


ATOM
2138
CG
LEU
A
157
64.937
−39.982
10.520
1.00
34.36
A
C


ATOM
2140
CD1
LEU
A
157
66.210
−39.356
9.983
1.00
31.72
A
C


ATOM
2144
CD2
LEU
A
157
63.996
−38.917
11.050
1.00
32.16
A
C


ATOM
2148
C
LEU
A
157
62.215
−41.330
8.271
1.00
27.68
A
C


ATOM
2149
O
LEU
A
157
61.279
−40.551
8.073
1.00
26.10
A
O


ATOM
2151
N
SER
A
158
62.658
−42.199
7.371
1.00
26.74
A
N


ATOM
2152
CA
SER
A
158
62.074
−42.255
6.064
1.00
27.94
A
C


ATOM
2154
CB
SER
A
158
62.861
−43.219
5.198
1.00
27.98
A
C


ATOM
2157
OG
SER
A
158
62.518
−43.042
3.845
1.00
44.57
A
O


ATOM
2159
C
SER
A
158
60.573
−42.600
6.186
1.00
25.94
A
C


ATOM
2160
O
SER
A
158
59.730
−41.938
5.574
1.00
23.44
A
O


ATOM
2162
N
LEU
A
159
60.227
−43.568
7.034
1.00
24.38
A
N


ATOM
2163
CA
LEU
A
159
58.807
−43.865
7.292
1.00
23.67
A
C


ATOM
2165
CB
LEU
A
159
58.667
−45.082
8.206
1.00
23.04
A
C


ATOM
2168
CG
LEU
A
159
57.261
−45.601
8.496
1.00
23.72
A
C


ATOM
2170
CD1
LEU
A
159
56.577
−46.056
7.202
1.00
19.76
A
C


ATOM
2174
CD2
LEU
A
159
57.295
−46.735
9.527
1.00
24.23
A
C


ATOM
2178
C
LEU
A
159
58.065
−42.651
7.881
1.00
22.73
A
C


ATOM
2179
O
LEU
A
159
56.955
−42.353
7.468
1.00
25.33
A
O


ATOM
2181
N
TYR
A
160
58.676
−41.950
8.834
1.00
21.28
A
N


ATOM
2182
CA
TYR
A
160
58.069
−40.740
9.406
1.00
19.99
A
C


ATOM
2184
CB
TYR
A
160
58.966
−40.158
10.499
1.00
16.21
A
C


ATOM
2187
CG
TYR
A
160
58.612
−38.765
11.028
1.00
15.97
A
C


ATOM
2188
CD1
TYR
A
160
57.726
−38.581
12.074
1.00
20.63
A
C


ATOM
2190
CE1
TYR
A
160
57.431
−37.309
12.550
1.00
23.21
A
C


ATOM
2192
CZ
TYR
A
160
58.069
−36.229
12.008
1.00
24.75
A
C


ATOM
2193
OH
TYR
A
160
57.813
−34.949
12.441
1.00
37.71
A
O


ATOM
2195
CE2
TYR
A
160
58.962
−36.401
10.988
1.00
27.54
A
C


ATOM
2197
CD2
TYR
A
160
59.228
−37.648
10.513
1.00
27.04
A
C


ATOM
2199
C
TYR
A
160
57.758
−39.715
8.301
1.00
20.86
A
C


ATOM
2200
O
TYR
A
160
56.670
−39.148
8.261
1.00
19.44
A
O


ATOM
2202
N
GLU
A
161
58.691
−39.529
7.376
1.00
22.74
A
N


ATOM
2203
CA
GLU
A
161
58.562
−38.479
6.366
1.00
22.29
A
C


ATOM
2205
CB
GLU
A
161
59.869
−38.239
5.586
1.00
22.32
A
C


ATOM
2208
CG
GLU
A
161
61.065
−37.781
6.403
1.00
25.25
A
C


ATOM
2211
CD
GLU
A
161
60.985
−36.329
6.883
1.00
29.78
A
C


ATOM
2212
OE1
GLU
A
161
59.985
−35.612
6.600
1.00
30.17
A
O


ATOM
2213
OE2
GLU
A
161
61.934
−35.925
7.588
1.00
23.68
A
O


ATOM
2214
C
GLU
A
161
57.477
−38.855
5.384
1.00
23.03
A
C


ATOM
2215
O
GLU
A
161
56.726
−37.983
4.954
1.00
23.28
A
O


ATOM
2217
N
ALA
A
162
57.404
−40.139
5.031
1.00
19.57
A
N


ATOM
2218
CA
ALA
A
162
56.377
−40.621
4.113
1.00
20.19
A
C


ATOM
2220
CB
ALA
A
162
56.619
−42.067
3.743
1.00
17.81
A
C


ATOM
2224
C
ALA
A
162
54.968
−40.459
4.674
1.00
20.85
A
C


ATOM
2225
O
ALA
A
162
54.042
−40.179
3.921
1.00
20.56
A
O


ATOM
2227
N
SER
A
163
54.795
−40.651
5.983
1.00
21.00
A
N


ATOM
2228
CA
SER
A
163
53.453
−40.617
6.584
1.00
20.15
A
C


ATOM
2230
CB
SER
A
163
53.512
−40.917
8.077
1.00
20.26
A
C


ATOM
2233
OG
SER
A
163
54.223
−39.914
8.772
1.00
22.70
A
O


ATOM
2235
C
SER
A
163
52.758
−39.276
6.398
1.00
20.14
A
C


ATOM
2236
O
SER
A
163
51.553
−39.212
6.412
1.00
21.29
A
O


ATOM
2238
N
PHE
A
164
53.505
−38.194
6.207
1.00
21.91
A
N


ATOM
2239
CA
PHE
A
164
52.852
−36.893
6.012
1.00
21.51
A
C


ATOM
2241
CB
PHE
A
164
53.783
−35.742
6.353
1.00
21.26
A
C


ATOM
2244
CG
PHE
A
164
54.107
−35.680
7.823
1.00
20.56
A
C


ATOM
2245
CD1
PHE
A
164
53.300
−34.984
8.692
1.00
19.82
A
C


ATOM
2247
CE1
PHE
A
164
53.593
−34.950
10.044
1.00
20.99
A
C


ATOM
2249
CZ
PHE
A
164
54.694
−35.621
10.537
1.00
19.87
A
C


ATOM
2251
CE2
PHE
A
164
55.491
−36.343
9.683
1.00
22.05
A
C


ATOM
2253
CD2
PHE
A
164
55.178
−36.390
8.335
1.00
19.04
A
C


ATOM
2255
C
PHE
A
164
52.235
−36.724
4.651
1.00
20.83
A
C


ATOM
2256
O
PHE
A
164
51.564
−35.732
4.420
1.00
20.53
A
O


ATOM
2258
N
LEU
A
165
52.434
−37.694
3.759
1.00
21.43
A
N


ATOM
2259
CA
LEU
A
165
51.817
−37.634
2.443
1.00
21.34
A
C


ATOM
2261
CB
LEU
A
165
52.808
−38.064
1.356
1.00
21.77
A
C


ATOM
2264
CG
LEU
A
165
53.927
−37.066
0.985
1.00
24.00
A
C


ATOM
2266
CD1
LEU
A
165
55.125
−37.119
1.950
1.00
24.11
A
C


ATOM
2270
CD2
LEU
A
165
54.414
−37.300
−0.424
1.00
21.22
A
C


ATOM
2274
C
LEU
A
165
50.496
−38.420
2.372
1.00
21.79
A
C


ATOM
2275
O
LEU
A
165
49.967
−38.657
1.306
1.00
24.21
A
O


ATOM
2277
N
ALA
A
166
49.957
−38.775
3.523
1.00
21.05
A
N


ATOM
2278
CA
ALA
A
166
48.760
−39.562
3.627
1.00
21.13
A
C


ATOM
2280
CB
ALA
A
166
48.449
−39.848
5.112
1.00
16.14
A
C


ATOM
2284
C
ALA
A
166
47.564
−38.887
2.998
1.00
22.34
A
C


ATOM
2285
O
ALA
A
166
47.448
−37.664
3.031
1.00
23.04
A
O


ATOM
2287
N
LEU
A
167
46.670
−39.710
2.446
1.00
22.65
A
N


ATOM
2288
CA
LEU
A
167
45.315
−39.299
2.123
1.00
22.73
A
C


ATOM
2290
CB
LEU
A
167
44.903
−39.929
0.805
1.00
22.79
A
C


ATOM
2293
CG
LEU
A
167
45.870
−39.733
−0.367
1.00
29.42
A
C


ATOM
2295
CD1
LEU
A
167
45.269
−40.327
−1.669
1.00
17.64
A
C


ATOM
2299
CD2
LEU
A
167
46.250
−38.249
−0.540
1.00
18.14
A
C


ATOM
2303
C
LEU
A
167
44.351
−39.758
3.235
1.00
23.82
A
C


ATOM
2304
O
LEU
A
167
44.694
−40.592
4.059
1.00
22.47
A
O


ATOM
2306
N
GLU
A
168
43.139
−39.228
3.239
1.00
24.07
A
N


ATOM
2307
CA
GLU
A
168
42.132
−39.692
4.157
1.00
25.29
A
C


ATOM
2309
CB
GLU
A
168
40.818
−38.931
3.943
1.00
27.27
A
C


ATOM
2312
CG
GLU
A
168
40.738
−37.525
4.576
1.00
30.92
A
C


ATOM
2315
CD
GLU
A
168
39.356
−36.894
4.371
1.00
38.89
A
C


ATOM
2316
OE1
GLU
A
168
38.996
−36.617
3.199
1.00
36.18
A
O


ATOM
2317
OE2
GLU
A
168
38.626
−36.700
5.379
1.00
42.80
A
O


ATOM
2318
C
GLU
A
168
41.902
−41.186
3.935
1.00
25.25
A
C


ATOM
2319
O
GLU
A
168
41.855
−41.652
2.798
1.00
22.24
A
O


ATOM
2321
N
GLY
A
169
41.748
−41.928
5.034
1.00
24.73
A
N


ATOM
2322
CA
GLY
A
169
41.540
−43.370
4.977
1.00
21.86
A
C


ATOM
2325
C
GLY
A
169
42.785
−44.213
5.048
1.00
21.58
A
C


ATOM
2326
O
GLY
A
169
42.692
−45.426
5.190
1.00
24.46
A
O


ATOM
2328
N
GLU
A
170
43.956
−43.598
4.967
1.00
20.95
A
N


ATOM
2329
CA
GLU
A
170
45.179
−44.378
4.872
1.00
21.33
A
C


ATOM
2331
CB
GLU
A
170
46.219
−43.717
3.960
1.00
16.76
A
C


ATOM
2334
CG
GLU
A
170
45.778
−43.588
2.518
1.00
22.22
A
C


ATOM
2337
CD
GLU
A
170
46.915
−43.209
1.542
1.00
28.05
A
C


ATOM
2338
OE1
GLU
A
170
47.070
−43.885
0.497
1.00
32.07
A
O


ATOM
2339
OE2
GLU
A
170
47.654
−42.242
1.822
1.00
24.57
A
O


ATOM
2340
C
GLU
A
170
45.699
−44.577
6.271
1.00
21.42
A
C


ATOM
2341
O
GLU
A
170
46.699
−43.979
6.686
1.00
21.14
A
O


ATOM
2343
N
ASN
A
171
45.000
−45.435
6.992
1.00
21.46
A
N


ATOM
2344
CA
ASN
A
171
45.247
−45.636
8.406
1.00
23.53
A
C


ATOM
2346
CB
ASN
A
171
44.197
−46.587
8.999
1.00
24.69
A
C


ATOM
2349
CG
ASN
A
171
44.256
−47.982
8.375
1.00
28.66
A
C


ATOM
2350
OD1
ASN
A
171
43.992
−48.155
7.177
1.00
21.35
A
O


ATOM
2351
ND2
ASN
A
171
44.645
−48.972
9.178
1.00
19.68
A
N


ATOM
2354
C
ASN
A
171
46.648
−46.164
8.692
1.00
24.20
A
C


ATOM
2355
O
ASN
A
171
47.193
−45.894
9.753
1.00
24.52
A
O


ATOM
2357
N
ILE
A
172
47.217
−46.909
7.745
1.00
25.20
A
N


ATOM
2358
CA
ILE
A
172
48.549
−47.478
7.893
1.00
27.16
A
C


ATOM
2360
CB
ILE
A
172
48.898
−48.455
6.738
1.00
27.07
A
C


ATOM
2362
CG1
ILE
A
172
47.981
−49.677
6.764
1.00
30.96
A
C


ATOM
2365
CD1
ILE
A
172
48.252
−50.653
5.616
1.00
34.90
A
C


ATOM
2369
CG2
ILE
A
172
50.354
−48.935
6.825
1.00
23.91
A
C


ATOM
2373
C
ILE
A
172
49.595
−46.348
8.004
1.00
28.36
A
C


ATOM
2374
O
ILE
A
172
50.534
−46.443
8.787
1.00
29.81
A
O


ATOM
2376
N
LEU
A
173
49.393
−45.268
7.264
1.00
27.42
A
N


ATOM
2377
CA
LEU
A
173
50.326
−44.141
7.300
1.00
27.76
A
C


ATOM
2379
CB
LEU
A
173
50.138
−43.217
6.096
1.00
27.01
A
C


ATOM
2382
CG
LEU
A
173
50.933
−43.554
4.842
1.00
27.25
A
C


ATOM
2384
CD1
LEU
A
173
50.747
−44.951
4.446
1.00
27.88
A
C


ATOM
2388
CD2
LEU
A
173
50.482
−42.633
3.687
1.00
29.35
A
C


ATOM
2392
C
LEU
A
173
50.197
−43.362
8.605
1.00
26.43
A
C


ATOM
2393
O
LEU
A
173
51.201
−42.925
9.141
1.00
25.15
A
O


ATOM
2395
N
ASP
A
174
48.981
−43.205
9.121
1.00
24.34
A
N


ATOM
2396
CA
ASP
A
174
48.792
−42.610
10.443
1.00
26.66
A
C


ATOM
2398
CB
ASP
A
174
47.310
−42.444
10.771
1.00
27.51
A
C


ATOM
2401
CG
ASP
A
174
46.649
−41.327
9.959
1.00
34.04
A
C


ATOM
2402
OD1
ASP
A
174
47.363
−40.551
9.305
1.00
40.90
A
O


ATOM
2403
OD2
ASP
A
174
45.406
−41.228
9.980
1.00
42.95
A
O


ATOM
2404
C
ASP
A
174
49.438
−43.451
11.539
1.00
27.18
A
C


ATOM
2405
O
ASP
A
174
50.099
−42.926
12.432
1.00
28.53
A
O


ATOM
2407
N
GLU
A
175
49.228
−44.756
11.480
1.00
28.79
A
N


ATOM
2408
CA
GLU
A
175
49.843
−45.659
12.431
1.00
29.42
A
C


ATOM
2410
CB
GLU
A
175
49.321
−47.083
12.237
1.00
29.10
A
C


ATOM
2413
CG
GLU
A
175
47.835
−47.244
12.560
1.00
36.91
A
C


ATOM
2416
CD
GLU
A
175
47.189
−48.421
11.819
1.00
41.63
A
C


ATOM
2417
OE1
GLU
A
175
47.928
−49.311
11.327
1.00
42.73
A
O


ATOM
2418
OE2
GLU
A
175
45.946
−48.436
11.719
1.00
39.01
A
O


ATOM
2419
C
GLU
A
175
51.356
−45.616
12.230
1.00
27.89
A
C


ATOM
2420
O
GLU
A
175
52.100
−45.726
13.180
1.00
27.43
A
O


ATOM
2422
N
ALA
A
176
51.797
−45.473
10.982
1.00
27.66
A
N


ATOM
2423
CA
ALA
A
176
53.225
−45.370
10.668
1.00
28.24
A
C


ATOM
2425
CB
ALA
A
176
53.428
−45.280
9.153
1.00
26.14
A
C


ATOM
2429
C
ALA
A
176
53.872
−44.173
11.387
1.00
27.46
A
C


ATOM
2430
O
ALA
A
176
54.970
−44.276
11.929
1.00
27.53
A
O


ATOM
2432
N
LYS
A
177
53.155
−43.055
11.418
1.00
26.90
A
N


ATOM
2433
CA
LYS
A
177
53.626
−41.840
12.060
1.00
27.36
A
C


ATOM
2435
CB
LYS
A
177
52.670
−40.666
11.775
1.00
26.52
A
C


ATOM
2438
CG
LYS
A
177
53.138
−39.310
12.294
1.00
26.21
A
C


ATOM
2441
CD
LYS
A
177
52.073
−38.200
12.199
1.00
27.44
A
C


ATOM
2444
CE
LYS
A
177
51.689
−37.893
10.754
1.00
28.20
A
C


ATOM
2447
NZ
LYS
A
177
50.565
−36.898
10.663
1.00
27.57
A
N


ATOM
2451
C
LYS
A
177
53.783
−42.067
13.558
1.00
28.77
A
C


ATOM
2452
O
LYS
A
177
54.830
−41.743
14.117
1.00
28.26
A
O


ATOM
2454
N
VAL
A
178
52.749
−42.617
14.196
1.00
29.28
A
N


ATOM
2455
CA
VAL
A
178
52.737
−42.855
15.654
1.00
27.74
A
C


ATOM
2457
CB
VAL
A
178
51.409
−43.524
16.103
1.00
28.79
A
C


ATOM
2459
CG1
VAL
A
178
51.481
−44.089
17.585
1.00
22.40
A
C


ATOM
2463
CG2
VAL
A
178
50.228
−42.565
15.919
1.00
23.47
A
C


ATOM
2467
C
VAL
A
178
53.907
−43.758
16.025
1.00
29.18
A
C


ATOM
2468
O
VAL
A
178
54.651
−43.485
16.955
1.00
30.11
A
O


ATOM
2470
N
PHE
A
179
54.058
−44.838
15.273
1.00
28.49
A
N


ATOM
2471
CA
PHE
A
179
55.168
−45.759
15.448
1.00
28.24
A
C


ATOM
2473
CB
PHE
A
179
54.990
−46.915
14.466
1.00
28.43
A
C


ATOM
2476
CG
PHE
A
179
56.115
−47.880
14.457
1.00
29.30
A
C


ATOM
2477
CD1
PHE
A
179
56.233
−48.824
15.453
1.00
30.81
A
C


ATOM
2479
CE1
PHE
A
179
57.278
−49.725
15.441
1.00
28.19
A
C


ATOM
2481
CZ
PHE
A
179
58.208
−49.687
14.431
1.00
30.08
A
C


ATOM
2483
CE2
PHE
A
179
58.089
−48.755
13.424
1.00
30.12
A
C


ATOM
2485
CD2
PHE
A
179
57.051
−47.860
13.444
1.00
29.06
A
C


ATOM
2487
C
PHE
A
179
56.555
−45.097
15.276
1.00
28.33
A
C


ATOM
2488
O
PHE
A
179
57.435
−45.283
16.104
1.00
25.10
A
O


ATOM
2490
N
ALA
A
180
56.757
−44.332
14.204
1.00
28.10
A
N


ATOM
2491
CA
ALA
A
180
58.054
−43.728
13.971
1.00
26.76
A
C


ATOM
2493
CB
ALA
A
180
58.150
−43.168
12.577
1.00
24.69
A
C


ATOM
2497
C
ALA
A
180
58.382
−42.652
15.034
1.00
29.09
A
C


ATOM
2498
O
ALA
A
180
59.485
−42.646
15.586
1.00
27.52
A
O


ATOM
2500
N
ILE
A
181
57.420
−41.775
15.319
1.00
28.79
A
N


ATOM
2501
CA
ILE
A
181
57.591
−40.717
16.285
1.00
30.81
A
C


ATOM
2503
CB
ILE
A
181
56.310
−39.865
16.483
1.00
31.36
A
C


ATOM
2505
CG1
ILE
A
181
56.105
−38.909
15.302
1.00
38.18
A
C


ATOM
2508
CD1
ILE
A
181
54.765
−38.081
15.352
1.00
37.32
A
C


ATOM
2512
CG2
ILE
A
181
56.415
−39.000
17.738
1.00
34.50
A
C


ATOM
2516
C
ILE
A
181
58.002
−41.293
17.629
1.00
33.92
A
C


ATOM
2517
O
ILE
A
181
58.908
−40.757
18.270
1.00
32.34
A
O


ATOM
2519
N
SER
A
182
57.359
−42.383
18.045
1.00
34.21
A
N


ATOM
2520
CA
SER
A
182
57.608
−42.923
19.361
1.00
37.21
A
C


ATOM
2522
CB
SER
A
182
56.573
−43.991
19.721
1.00
37.94
A
C


ATOM
2525
OG
SER
A
182
56.744
−45.180
18.958
1.00
41.64
A
O


ATOM
2527
C
SER
A
182
59.030
−43.474
19.473
1.00
38.60
A
C


ATOM
2528
O
SER
A
182
59.618
−43.437
20.553
1.00
40.23
A
O


ATOM
2530
N
HIS
A
183
59.570
−43.982
18.366
1.00
38.90
A
N


ATOM
2531
CA
HIS
A
183
60.933
−44.519
18.342
1.00
40.39
A
C


ATOM
2533
CB
HIS
A
183
61.054
−45.715
17.401
1.00
39.71
A
C


ATOM
2536
CG
HIS
A
183
60.270
−46.913
17.839
1.00
46.09
A
C


ATOM
2537
ND1
HIS
A
183
60.409
−47.479
19.089
1.00
52.45
A
N


ATOM
2539
CE1
HIS
A
183
59.597
−48.516
19.192
1.00
55.12
A
C


ATOM
2541
NE2
HIS
A
183
58.945
−48.648
18.051
1.00
54.77
A
N


ATOM
2543
CD2
HIS
A
183
59.349
−47.660
17.188
1.00
47.51
A
C


ATOM
2545
C
HIS
A
183
61.972
−43.469
17.945
1.00
41.16
A
C


ATOM
2546
O
HIS
A
183
63.162
−43.724
18.087
1.00
44.04
A
O


ATOM
2548
N
LEU
A
184
61.536
−42.314
17.439
1.00
38.00
A
N


ATOM
2549
CA
LEU
A
184
62.448
−41.207
17.193
1.00
37.65
A
C


ATOM
2551
CB
LEU
A
184
62.018
−40.400
15.968
1.00
34.76
A
C


ATOM
2554
CG
LEU
A
184
62.130
−41.133
14.624
1.00
35.32
A
C


ATOM
2556
CD1
LEU
A
184
61.311
−40.390
13.576
1.00
22.44
A
C


ATOM
2560
CD2
LEU
A
184
63.579
−41.297
14.167
1.00
24.78
A
C


ATOM
2564
C
LEU
A
184
62.591
−40.267
18.400
1.00
37.45
A
C


ATOM
2565
O
LEU
A
184
63.620
−39.647
18.551
1.00
33.63
A
O


ATOM
2567
N
LYS
A
185
61.558
−40.165
19.231
1.00
40.96
A
N


ATOM
2568
CA
LYS
A
185
61.490
−39.158
20.286
1.00
46.25
A
C


ATOM
2570
CB
LYS
A
185
60.062
−39.043
20.825
1.00
47.18
A
C


ATOM
2573
CG
LYS
A
185
59.568
−37.619
20.940
1.00
54.79
A
C


ATOM
2576
CD
LYS
A
185
58.037
−37.534
21.071
1.00
62.29
A
C


ATOM
2579
CE
LYS
A
185
57.489
−36.307
20.328
1.00
65.20
A
C


ATOM
2582
NZ
LYS
A
185
56.019
−36.110
20.508
1.00
64.22
A
N


ATOM
2586
C
LYS
A
185
62.412
−39.502
21.447
1.00
50.17
A
C


ATOM
2587
O
LYS
A
185
62.835
−38.626
22.190
1.00
50.48
A
O


ATOM
2589
N
GLU
A
186
62.695
−40.786
21.608
1.00
54.79
A
N


ATOM
2590
CA
GLU
A
186
63.492
−41.268
22.714
1.00
59.57
A
C


ATOM
2592
CB
GLU
A
186
62.748
−42.417
23.422
1.00
61.31
A
C


ATOM
2595
CG
GLU
A
186
61.324
−42.053
23.918
1.00
65.37
A
C


ATOM
2598
CD
GLU
A
186
61.289
−40.817
24.837
1.00
71.20
A
C


ATOM
2599
OE1
GLU
A
186
62.279
−40.570
25.570
1.00
72.40
A
O


ATOM
2600
OE2
GLU
A
186
60.266
−40.090
24.826
1.00
69.58
A
O


ATOM
2601
C
GLU
A
186
64.859
−41.715
22.199
1.00
61.26
A
C


ATOM
2602
O
GLU
A
186
65.344
−42.800
22.545
1.00
61.31
A
O


ATOM
2604
N
LEU
A
187
65.474
−40.871
21.368
1.00
61.95
A
N


ATOM
2605
CA
LEU
A
187
66.803
−41.144
20.832
1.00
62.48
A
C


ATOM
2607
CB
LEU
A
187
66.795
−41.069
19.309
1.00
61.46
A
C


ATOM
2610
CG
LEU
A
187
66.046
−42.207
18.622
1.00
60.67
A
C


ATOM
2612
CD1
LEU
A
187
66.159
−42.112
17.107
1.00
54.64
A
C


ATOM
2616
CD2
LEU
A
187
66.571
−43.549
19.105
1.00
60.19
A
C


ATOM
2620
C
LEU
A
187
67.848
−40.185
21.403
1.00
64.11
A
C


ATOM
2621
O
LEU
A
187
67.646
−38.964
21.436
1.00
63.36
A
O


ATOM
2623
N
SER
A
188
68.968
−40.764
21.842
1.00
66.14
A
N


ATOM
2624
CA
SER
A
188
70.064
−40.014
22.460
1.00
66.96
A
C


ATOM
2626
CB
SER
A
188
70.591
−40.762
23.685
1.00
67.57
A
C


ATOM
2629
OG
SER
A
188
69.575
−40.923
24.660
1.00
70.39
A
O


ATOM
2631
C
SER
A
188
71.203
−39.809
21.472
1.00
66.59
A
C


ATOM
2632
O
SER
A
188
71.607
−40.744
20.766
1.00
64.52
A
O


ATOM
2634
N
GLU
A
189
71.720
−38.583
21.438
1.00
67.77
A
N


ATOM
2635
CA
GLU
A
189
72.847
−38.231
20.578
1.00
69.56
A
C


ATOM
2637
CB
GLU
A
189
73.248
−36.765
20.791
1.00
70.17
A
C


ATOM
2640
CG
GLU
A
189
74.339
−36.266
19.841
1.00
73.91
A
C


ATOM
2643
CD
GLU
A
189
74.480
−34.742
19.820
1.00
79.04
A
C


ATOM
2644
OE1
GLU
A
189
73.752
−34.043
20.565
1.00
78.69
A
O


ATOM
2645
OE2
GLU
A
189
75.329
−34.244
19.044
1.00
81.94
A
O


ATOM
2646
C
GLU
A
189
74.039
−39.156
20.818
1.00
70.07
A
C


ATOM
2647
O
GLU
A
189
74.733
−39.517
19.875
1.00
68.55
A
O


ATOM
2649
N
GLU
A
190
74.260
−39.536
22.078
1.00
71.69
A
N


ATOM
2650
CA
GLU
A
190
75.327
−40.477
22.448
1.00
72.75
A
C


ATOM
2652
CB
GLU
A
190
75.285
−40.796
23.952
1.00
73.95
A
C


ATOM
2655
CG
GLU
A
190
76.108
−39.856
24.832
1.00
77.12
A
C


ATOM
2658
CD
GLU
A
190
75.626
−38.415
24.801
1.00
81.42
A
C


ATOM
2659
OE1
GLU
A
190
74.514
−38.146
24.284
1.00
82.03
A
O


ATOM
2660
OE2
GLU
A
190
76.372
−37.546
25.303
1.00
83.94
A
O


ATOM
2661
C
GLU
A
190
75.242
−41.777
21.654
1.00
72.09
A
C


ATOM
2662
O
GLU
A
190
76.225
−42.207
21.051
1.00
72.00
A
O


ATOM
2664
N
LYS
A
191
74.058
−42.384
21.648
1.00
71.50
A
N


ATOM
2665
CA
LYS
A
191
73.837
−43.669
20.977
1.00
71.87
A
C


ATOM
2667
CB
LYS
A
191
72.406
−44.167
21.222
1.00
72.85
A
C


ATOM
2670
CG
LYS
A
191
71.999
−44.262
22.685
1.00
77.73
A
C


ATOM
2673
CD
LYS
A
191
72.705
−45.417
23.395
1.00
84.01
A
C


ATOM
2676
CE
LYS
A
191
72.961
−45.117
24.873
1.00
85.51
A
C


ATOM
2679
NZ
LYS
A
191
74.197
−45.799
25.352
1.00
86.45
A
N


ATOM
2683
C
LYS
A
191
74.081
−43.581
19.467
1.00
70.30
A
C


ATOM
2684
O
LYS
A
191
74.929
−44.293
18.923
1.00
70.06
A
O


ATOM
2686
N
ILE
A
192
73.337
−42.700
18.803
1.00
68.27
A
N


ATOM
2687
CA
ILE
A
192
73.412
−42.559
17.344
1.00
67.41
A
C


ATOM
2689
CB
ILE
A
192
72.021
−42.259
16.721
1.00
66.84
A
C


ATOM
2691
CG1
ILE
A
192
71.413
−40.959
17.266
1.00
66.08
A
C


ATOM
2694
CD1
ILE
A
192
70.180
−40.498
16.516
1.00
61.79
A
C


ATOM
2698
CG2
ILE
A
192
71.079
−43.397
17.011
1.00
66.67
A
C


ATOM
2702
C
ILE
A
192
74.418
−41.476
16.984
1.00
66.49
A
C


ATOM
2703
O
ILE
A
192
75.005
−40.860
17.864
1.00
65.60
A
O


ATOM
2705
N
GLY
A
193
74.623
−41.241
15.694
1.00
66.38
A
N


ATOM
2706
CA
GLY
A
193
75.553
−40.195
15.259
1.00
66.52
A
C


ATOM
2709
C
GLY
A
193
75.264
−38.810
15.831
1.00
65.05
A
C


ATOM
2710
O
GLY
A
193
74.192
−38.557
16.396
1.00
64.86
A
O


ATOM
2712
N
LYS
A
194
76.235
−37.910
15.701
1.00
62.68
A
N


ATOM
2713
CA
LYS
A
194
75.958
−36.492
15.879
1.00
61.11
A
C


ATOM
2715
CB
LYS
A
194
77.243
−35.657
15.953
1.00
62.09
A
C


ATOM
2718
CG
LYS
A
194
78.355
−36.254
16.839
1.00
69.49
A
C


ATOM
2721
CD
LYS
A
194
79.386
−35.198
17.291
1.00
73.25
A
C


ATOM
2724
CE
LYS
A
194
80.488
−35.828
18.136
1.00
73.20
A
C


ATOM
2727
NZ
LYS
A
194
81.352
−34.809
18.783
1.00
72.29
A
N


ATOM
2731
C
LYS
A
194
75.096
−36.058
14.680
1.00
58.07
A
C


ATOM
2732
O
LYS
A
194
74.119
−35.337
14.842
1.00
56.95
A
O


ATOM
2734
N
GLU
A
195
75.447
−36.528
13.484
1.00
54.22
A
N


ATOM
2735
CA
GLU
A
195
74.722
−36.140
12.287
1.00
53.49
A
C


ATOM
2737
CB
GLU
A
195
75.507
−36.489
11.005
1.00
53.97
A
C


ATOM
2740
CG
GLU
A
195
75.487
−37.950
10.549
1.00
60.23
A
C


ATOM
2743
CD
GLU
A
195
76.394
−38.208
9.329
1.00
66.28
A
C


ATOM
2744
OE1
GLU
A
195
76.046
−39.079
8.500
1.00
68.96
A
O


ATOM
2745
OE2
GLU
A
195
77.450
−37.544
9.194
1.00
62.48
A
O


ATOM
2746
C
GLU
A
195
73.296
−36.714
12.261
1.00
50.83
A
C


ATOM
2747
O
GLU
A
195
72.363
−36.050
11.773
1.00
48.97
A
O


ATOM
2749
N
LEU
A
196
73.125
−37.925
12.792
1.00
46.53
A
N


ATOM
2750
CA
LEU
A
196
71.808
−38.556
12.821
1.00
43.53
A
C


ATOM
2752
CB
LEU
A
196
71.892
−40.048
13.130
1.00
43.43
A
C


ATOM
2755
CG
LEU
A
196
71.893
−40.894
11.870
1.00
43.50
A
C


ATOM
2757
CD1
LEU
A
196
72.472
−42.286
12.143
1.00
46.58
A
C


ATOM
2761
CD2
LEU
A
196
70.472
−40.959
11.279
1.00
43.97
A
C


ATOM
2765
C
LEU
A
196
70.881
−37.857
13.799
1.00
40.68
A
C


ATOM
2766
O
LEU
A
196
69.731
−37.587
13.461
1.00
40.50
A
O


ATOM
2768
N
ALA
A
197
71.383
−37.531
14.983
1.00
36.99
A
N


ATOM
2769
CA
ALA
A
197
70.584
−36.804
15.961
1.00
35.57
A
C


ATOM
2771
CB
ALA
A
197
71.364
−36.595
17.246
1.00
33.51
A
C


ATOM
2775
C
ALA
A
197
70.119
−35.460
15.406
1.00
35.11
A
C


ATOM
2776
O
ALA
A
197
68.995
−35.042
15.677
1.00
35.72
A
O


ATOM
2778
N
GLU
A
198
70.986
−34.778
14.653
1.00
33.60
A
N


ATOM
2779
CA
GLU
A
198
70.605
−33.513
14.002
1.00
35.29
A
C


ATOM
2781
CB
GLU
A
198
71.836
−32.795
13.432
1.00
36.22
A
C


ATOM
2784
CG
GLU
A
198
72.762
−32.235
14.540
1.00
50.06
A
C


ATOM
2787
CD
GLU
A
198
74.148
−31.764
14.057
1.00
60.04
A
C


ATOM
2788
OE1
GLU
A
198
74.806
−32.492
13.272
1.00
66.90
A
O


ATOM
2789
OE2
GLU
A
198
74.585
−30.667
14.491
1.00
63.26
A
O


ATOM
2790
C
GLU
A
198
69.534
−33.754
12.916
1.00
31.70
A
C


ATOM
2791
O
GLU
A
198
68.608
−32.969
12.768
1.00
33.74
A
O


ATOM
2793
N
GLN
A
199
69.647
−34.857
12.201
1.00
28.08
A
N


ATOM
2794
CA
GLN
A
199
68.694
−35.215
11.158
1.00
29.52
A
C


ATOM
2796
CB
GLN
A
199
69.315
−36.342
10.323
1.00
30.33
A
C


ATOM
2799
CG
GLN
A
199
68.764
−36.594
8.954
1.00
42.18
A
C


ATOM
2802
CD
GLN
A
199
69.077
−35.489
7.927
1.00
53.91
A
C


ATOM
2803
OE1
GLN
A
199
68.161
−34.927
7.316
1.00
54.02
A
O


ATOM
2804
NE2
GLN
A
199
70.359
−35.211
7.705
1.00
47.12
A
N


ATOM
2807
C
GLN
A
199
67.326
−35.566
11.828
1.00
27.82
A
C


ATOM
2808
O
GLN
A
199
66.277
−35.071
11.419
1.00
24.92
A
O


ATOM
2810
N
VAL
A
200
67.361
−36.329
12.922
1.00
27.96
A
N


ATOM
2811
CA
VAL
A
200
66.162
−36.642
13.712
1.00
26.88
A
C


ATOM
2813
CB
VAL
A
200
66.485
−37.637
14.821
1.00
28.23
A
C


ATOM
2815
CG1
VAL
A
200
66.795
−39.011
14.204
1.00
29.92
A
C


ATOM
2819
CG2
VAL
A
200
65.342
−37.736
15.839
1.00
23.69
A
C


ATOM
2823
C
VAL
A
200
65.496
−35.422
14.336
1.00
27.44
A
C


ATOM
2824
O
VAL
A
200
64.277
−35.274
14.235
1.00
26.51
A
O


ATOM
2826
N
ASN
A
201
66.288
−34.536
14.946
1.00
27.44
A
N


ATOM
2827
CA
ASN
A
201
65.754
−33.319
15.554
1.00
29.08
A
C


ATOM
2829
CB
ASN
A
201
66.835
−32.603
16.398
1.00
30.46
A
C


ATOM
2832
CG
ASN
A
201
67.362
−33.468
17.575
1.00
34.58
A
C


ATOM
2833
OD1
ASN
A
201
66.665
−34.330
18.124
1.00
43.42
A
O


ATOM
2834
ND2
ASN
A
201
68.604
−33.231
17.947
1.00
39.12
A
N


ATOM
2837
C
ASN
A
201
65.140
−32.337
14.530
1.00
28.73
A
C


ATOM
2838
O
ASN
A
201
64.107
−31.710
14.783
1.00
27.87
A
O


ATOM
2840
N
HIS
A
202
65.784
−32.192
13.382
1.00
27.02
A
N


ATOM
2841
CA
HIS
A
202
65.237
−31.386
12.299
1.00
26.81
A
C


ATOM
2843
CB
HIS
A
202
66.303
−31.281
11.211
1.00
27.94
A
C


ATOM
2846
CG
HIS
A
202
65.862
−30.625
9.942
1.00
26.52
A
C


ATOM
2847
ND1
HIS
A
202
65.804
−29.258
9.788
1.00
29.59
A
N


ATOM
2849
CE1
HIS
A
202
65.435
−28.970
8.554
1.00
28.13
A
C


ATOM
2851
NE2
HIS
A
202
65.288
−30.102
7.890
1.00
26.07
A
N


ATOM
2853
CD2
HIS
A
202
65.564
−31.150
8.733
1.00
26.24
A
C


ATOM
2855
C
HIS
A
202
63.901
−32.018
11.785
1.00
25.69
A
C


ATOM
2856
O
HIS
A
202
62.890
−31.339
11.667
1.00
21.65
A
O


ATOM
2858
N
ALA
A
203
63.867
−33.315
11.553
1.00
25.23
A
N


ATOM
2859
CA
ALA
A
203
62.598
−33.931
11.112
1.00
25.49
A
C


ATOM
2861
CB
ALA
A
203
62.812
−35.337
10.748
1.00
24.59
A
C


ATOM
2865
C
ALA
A
203
61.489
−33.824
12.173
1.00
27.25
A
C


ATOM
2866
O
ALA
A
203
60.321
−33.627
11.837
1.00
29.18
A
O


ATOM
2868
N
LEU
A
204
61.839
−33.928
13.451
1.00
26.81
A
N


ATOM
2869
CA
LEU
A
204
60.807
−33.831
14.517
1.00
26.42
A
C


ATOM
2871
CB
LEU
A
204
61.317
−34.405
15.850
1.00
24.88
A
C


ATOM
2874
CG
LEU
A
204
61.517
−35.936
15.832
1.00
26.48
A
C


ATOM
2876
CD1
LEU
A
204
62.119
−36.465
17.114
1.00
26.30
A
C


ATOM
2880
CD2
LEU
A
204
60.203
−36.639
15.557
1.00
23.97
A
C


ATOM
2884
C
LEU
A
204
60.305
−32.392
14.672
1.00
27.71
A
C


ATOM
2885
O
LEU
A
204
59.148
−32.160
15.001
1.00
27.30
A
O


ATOM
2887
N
GLU
A
205
61.183
−31.430
14.415
1.00
27.31
A
N


ATOM
2888
CA
GLU
A
205
60.805
−30.037
14.394
1.00
27.78
A
C


ATOM
2890
CB
GLU
A
205
62.015
−29.143
14.068
1.00
27.71
A
C


ATOM
2893
CG
GLU
A
205
61.697
−27.658
14.056
1.00
29.29
A
C


ATOM
2896
CD
GLU
A
205
62.860
−26.816
13.541
1.00
37.90
A
C


ATOM
2897
OE1
GLU
A
205
63.289
−27.047
12.395
1.00
32.00
A
O


ATOM
2898
OE2
GLU
A
205
63.349
−25.930
14.288
1.00
44.77
A
O


ATOM
2899
C
GLU
A
205
59.729
−29.859
13.348
1.00
27.03
A
C


ATOM
2900
O
GLU
A
205
58.699
−29.270
13.627
1.00
27.56
A
O


ATOM
2902
N
LEU
A
206
59.982
−30.359
12.144
1.00
25.59
A
N


ATOM
2903
CA
LEU
A
206
59.004
−30.289
11.062
1.00
25.22
A
C


ATOM
2905
CB
LEU
A
206
58.886
−28.840
10.561
1.00
24.64
A
C


ATOM
2908
CG
LEU
A
206
57.694
−28.433
9.711
1.00
24.27
A
C


ATOM
2910
CD1
LEU
A
206
56.411
−28.371
10.529
1.00
17.46
A
C


ATOM
2914
CD2
LEU
A
206
57.955
−27.063
9.063
1.00
21.01
A
C


ATOM
2918
C
LEU
A
206
59.416
−31.196
9.917
1.00
24.56
A
C


ATOM
2919
O
LEU
A
206
60.540
−31.118
9.444
1.00
25.68
A
O


ATOM
2921
N
PRO
A
207
58.492
−32.045
9.437
1.00
24.29
A
N


ATOM
2922
CA
PRO
A
207
58.784
−32.963
8.354
1.00
23.07
A
C


ATOM
2924
CB
PRO
A
207
57.522
−33.795
8.289
1.00
25.30
A
C


ATOM
2927
CG
PRO
A
207
56.469
−32.830
8.679
1.00
25.11
A
C


ATOM
2930
CD
PRO
A
207
57.058
−32.039
9.765
1.00
23.79
A
C


ATOM
2933
C
PRO
A
207
59.003
−32.256
7.014
1.00
21.55
A
C


ATOM
2934
O
PRO
A
207
58.522
−31.166
6.819
1.00
22.11
A
O


ATOM
2935
N
LEU
A
208
59.694
−32.924
6.102
1.00
22.41
A
N


ATOM
2936
CA
LEU
A
208
60.022
−32.401
4.805
1.00
22.23
A
C


ATOM
2938
CB
LEU
A
208
60.690
−33.496
3.997
1.00
26.10
A
C


ATOM
2941
CG
LEU
A
208
62.061
−33.942
4.475
1.00
32.53
A
C


ATOM
2943
CD1
LEU
A
208
62.395
−35.348
3.945
1.00
35.78
A
C


ATOM
2947
CD2
LEU
A
208
63.091
−32.897
4.009
1.00
35.33
A
C


ATOM
2951
C
LEU
A
208
58.814
−31.930
4.019
1.00
23.30
A
C


ATOM
2952
O
LEU
A
208
58.865
−30.914
3.333
1.00
27.80
A
O


ATOM
2954
N
HIS
A
209
57.733
−32.688
4.081
1.00
21.48
A
N


ATOM
2955
CA
HIS
A
209
56.531
−32.356
3.333
1.00
20.94
A
C


ATOM
2957
CB
HIS
A
209
55.497
−33.453
3.521
1.00
20.23
A
C


ATOM
2960
CG
HIS
A
209
54.347
−33.380
2.571
1.00
21.97
A
C


ATOM
2961
ND1
HIS
A
209
54.509
−33.408
1.200
1.00
19.00
A
N


ATOM
2963
CE1
HIS
A
209
53.316
−33.366
0.621
1.00
17.86
A
C


ATOM
2965
NE2
HIS
A
209
52.392
−33.319
1.568
1.00
20.62
A
N


ATOM
2967
CD2
HIS
A
209
53.011
−33.333
2.797
1.00
17.40
A
C


ATOM
2969
C
HIS
A
209
55.890
−31.039
3.769
1.00
20.60
A
C


ATOM
2970
O
HIS
A
209
55.095
−30.479
3.030
1.00
22.10
A
O


ATOM
2972
N
ARG
A
210
56.182
−30.578
4.970
1.00
19.06
A
N


ATOM
2973
CA
ARG
A
210
55.590
−29.330
5.442
1.00
21.68
A
C


ATOM
2975
CB
ARG
A
210
54.984
−29.513
6.825
1.00
21.62
A
C


ATOM
2978
CG
ARG
A
210
53.868
−30.527
6.845
1.00
21.69
A
C


ATOM
2981
CD
ARG
A
210
53.157
−30.548
8.198
1.00
21.87
A
C


ATOM
2984
NE
ARG
A
210
52.032
−31.469
8.145
1.00
28.50
A
N


ATOM
2986
CZ
ARG
A
210
51.306
−31.867
9.185
1.00
27.73
A
C


ATOM
2987
NH1
ARG
A
210
51.565
−31.422
10.396
1.00
25.20
A
N


ATOM
2990
NH2
ARG
A
210
50.306
−32.732
9.001
1.00
22.65
A
N


ATOM
2993
C
ARG
A
210
56.554
−28.162
5.510
1.00
23.56
A
C


ATOM
2994
O
ARG
A
210
56.098
−27.052
5.712
1.00
25.20
A
O


ATOM
2996
N
ARG
A
211
57.861
−28.390
5.317
1.00
22.15
A
N


ATOM
2997
CA
ARG
A
211
58.824
−27.328
5.454
1.00
22.08
A
C


ATOM
2999
CB
ARG
A
211
60.164
−27.898
5.911
1.00
21.53
A
C


ATOM
3002
CG
ARG
A
211
61.184
−26.803
6.252
1.00
25.30
A
C


ATOM
3005
CD
ARG
A
211
62.498
−27.377
6.683
1.00
23.90
A
C


ATOM
3008
NE
ARG
A
211
62.394
−28.298
7.815
1.00
20.68
A
N


ATOM
3010
CZ
ARG
A
211
62.577
−27.968
9.097
1.00
29.21
A
C


ATOM
3011
NH1
ARG
A
211
62.842
−26.723
9.458
1.00
31.64
A
N


ATOM
3014
NH2
ARG
A
211
62.482
−28.895
10.040
1.00
33.26
A
N


ATOM
3017
C
ARG
A
211
58.995
−26.636
4.124
1.00
22.87
A
C


ATOM
3018
O
ARG
A
211
58.943
−27.308
3.080
1.00
23.69
A
O


ATOM
3020
N
THR
A
212
59.225
−25.313
4.131
1.00
21.93
A
N


ATOM
3021
CA
THR
A
212
59.457
−24.587
2.846
1.00
22.40
A
C


ATOM
3023
CB
THR
A
212
59.553
−23.073
3.006
1.00
21.65
A
C


ATOM
3025
OG1
THR
A
212
60.391
−22.782
4.111
1.00
28.79
A
O


ATOM
3027
CG2
THR
A
212
58.204
−22.457
3.215
1.00
21.41
A
C


ATOM
3031
C
THR
A
212
60.748
−25.035
2.161
1.00
24.44
A
C


ATOM
3032
O
THR
A
212
61.667
−25.593
2.790
1.00
22.73
A
O


ATOM
3034
N
GLN
A
213
60.831
−24.769
0.862
1.00
24.88
A
N


ATOM
3035
CA
GLN
A
213
61.890
−25.361
0.042
1.00
23.30
A
C


ATOM
3037
CB
GLN
A
213
61.510
−25.230
−1.431
1.00
22.38
A
C


ATOM
3040
CG
GLN
A
213
62.232
−26.167
−2.392
1.00
26.87
A
C


ATOM
3043
CD
GLN
A
213
63.551
−25.606
−2.913
1.00
30.03
A
C


ATOM
3044
OE1
GLN
A
213
64.199
−24.764
−2.277
1.00
31.33
A
O


ATOM
3045
NE2
GLN
A
213
63.969
−26.095
−4.062
1.00
27.33
A
N


ATOM
3048
C
GLN
A
213
63.238
−24.674
0.385
1.00
23.77
A
C


ATOM
3049
O
GLN
A
213
64.269
−25.339
0.641
1.00
23.11
A
O


ATOM
3051
N
ARG
A
214
63.242
−23.348
0.444
1.00
22.75
A
N


ATOM
3052
CA
ARG
A
214
64.496
−22.646
0.771
1.00
22.94
A
C


ATOM
3054
CB
ARG
A
214
64.351
−21.150
0.591
1.00
21.67
A
C


ATOM
3057
CG
ARG
A
214
64.105
−20.728
−0.863
1.00
25.36
A
C


ATOM
3060
CD
ARG
A
214
65.370
−20.851
−1.745
1.00
25.37
A
C


ATOM
3063
NE
ARG
A
214
65.517
−22.198
−2.265
1.00
19.85
A
N


ATOM
3065
CZ
ARG
A
214
66.500
−22.609
−3.067
1.00
22.24
A
C


ATOM
3066
NH1
ARG
A
214
67.440
−21.780
−3.482
1.00
23.25
A
N


ATOM
3069
NH2
ARG
A
214
66.530
−23.870
−3.478
1.00
21.78
A
N


ATOM
3072
C
ARG
A
214
65.045
−22.987
2.163
1.00
22.57
A
C


ATOM
3073
O
ARG
A
214
66.276
−23.153
2.325
1.00
22.67
A
O


ATOM
3075
N
LEU
A
215
64.168
−23.142
3.156
1.00
21.88
A
N


ATOM
3076
CA
LEU
A
215
64.640
−23.425
4.534
1.00
22.10
A
C


ATOM
3078
CB
LEU
A
215
63.530
−23.342
5.574
1.00
23.69
A
C


ATOM
3081
CG
LEU
A
215
63.166
−22.064
6.320
1.00
34.74
A
C


ATOM
3083
CD1
LEU
A
215
64.377
−21.478
7.038
1.00
30.99
A
C


ATOM
3087
CD2
LEU
A
215
62.022
−22.394
7.334
1.00
34.69
A
C


ATOM
3091
C
LEU
A
215
65.225
−24.807
4.601
1.00
21.97
A
C


ATOM
3092
O
LEU
A
215
66.251
−25.033
5.243
1.00
23.04
A
O


ATOM
3094
N
GLU
A
216
64.563
−25.759
3.964
1.00
22.38
A
N


ATOM
3095
CA
GLU
A
216
65.143
−27.091
3.849
1.00
23.79
A
C


ATOM
3097
CB
GLU
A
216
64.203
−28.054
3.092
1.00
24.11
A
C


ATOM
3100
CG
GLU
A
216
64.735
−29.469
3.009
1.00
23.98
A
C


ATOM
3103
CD
GLU
A
216
65.092
−30.054
4.372
1.00
30.09
A
C


ATOM
3104
OE1
GLU
A
216
64.489
−29.635
5.368
1.00
38.31
A
O


ATOM
3105
OE2
GLU
A
216
65.963
−30.950
4.462
1.00
31.71
A
O


ATOM
3106
C
GLU
A
216
66.495
−27.043
3.151
1.00
22.00
A
C


ATOM
3107
O
GLU
A
216
67.417
−27.725
3.566
1.00
25.42
A
O


ATOM
3109
N
ALA
A
217
66.609
−26.265
2.075
1.00
21.69
A
N


ATOM
3110
CA
ALA
A
217
67.860
−26.207
1.307
1.00
21.04
A
C


ATOM
3112
CB
ALA
A
217
67.713
−25.322
0.057
1.00
16.62
A
C


ATOM
3116
C
ALA
A
217
68.997
−25.695
2.170
1.00
22.50
A
C


ATOM
3117
O
ALA
A
217
70.086
−26.294
2.207
1.00
24.32
A
O


ATOM
3119
N
VAL
A
218
68.754
−24.598
2.880
1.00
22.51
A
N


ATOM
3120
CA
VAL
A
218
69.841
−23.970
3.638
1.00
23.74
A
C


ATOM
3122
CB
VAL
A
218
69.501
−22.546
4.127
1.00
24.58
A
C


ATOM
3124
CG1
VAL
A
218
68.630
−22.593
5.350
1.00
23.58
A
C


ATOM
3128
CG2
VAL
A
218
70.816
−21.738
4.397
1.00
28.37
A
C


ATOM
3132
C
VAL
A
218
70.244
−24.871
4.785
1.00
23.83
A
C


ATOM
3133
O
VAL
A
218
71.408
−24.959
5.120
1.00
28.06
A
O


ATOM
3135
N
TRP
A
219
69.292
−25.582
5.366
1.00
25.17
A
N


ATOM
3136
CA
TRP
A
219
69.614
−26.553
6.384
1.00
24.87
A
C


ATOM
3138
CB
TRP
A
219
68.353
−27.038
7.105
1.00
25.79
A
C


ATOM
3141
CG
TRP
A
219
68.684
−27.877
8.273
1.00
25.24
A
C


ATOM
3142
CD1
TRP
A
219
68.904
−27.444
9.559
1.00
26.80
A
C


ATOM
3144
NE1
TRP
A
219
69.218
−28.508
10.361
1.00
24.26
A
N


ATOM
3146
CE2
TRP
A
219
69.240
−29.648
9.604
1.00
28.74
A
C


ATOM
3147
CD2
TRP
A
219
68.921
−29.281
8.274
1.00
20.92
A
C


ATOM
3148
CE3
TRP
A
219
68.869
−30.273
7.291
1.00
28.67
A
C


ATOM
3150
CZ3
TRP
A
219
69.133
−31.587
7.659
1.00
31.01
A
C


ATOM
3152
CH2
TRP
A
219
69.464
−31.920
8.991
1.00
31.59
A
C


ATOM
3154
CZ2
TRP
A
219
69.524
−30.968
9.974
1.00
31.18
A
C


ATOM
3156
C
TRP
A
219
70.368
−27.756
5.817
1.00
23.79
A
C


ATOM
3157
O
TRP
A
219
71.341
−28.186
6.403
1.00
26.06
A
O


ATOM
3159
N
SER
A
220
69.912
−28.314
4.700
1.00
23.59
A
N


ATOM
3160
CA
SER
A
220
70.515
−29.556
4.168
1.00
23.50
A
C


ATOM
3162
CB
SER
A
220
69.604
−30.197
3.104
1.00
23.55
A
C


ATOM
3165
OG
SER
A
220
68.632
−31.034
3.711
1.00
29.70
A
O


ATOM
3167
C
SER
A
220
71.909
−29.365
3.572
1.00
23.39
A
C


ATOM
3168
O
SER
A
220
72.739
−30.270
3.630
1.00
25.12
A
O


ATOM
3170
N
ILE
A
221
72.141
−28.206
2.976
1.00
23.77
A
N


ATOM
3171
CA
ILE
A
221
73.448
−27.844
2.429
1.00
27.11
A
C


ATOM
3173
CB
ILE
A
221
73.397
−26.472
1.704
1.00
26.36
A
C


ATOM
3175
CG1
ILE
A
221
72.680
−26.608
0.360
1.00
22.83
A
C


ATOM
3178
CD1
ILE
A
221
72.358
−25.299
−0.336
1.00
15.93
A
C


ATOM
3182
CG2
ILE
A
221
74.804
−25.940
1.473
1.00
28.45
A
C


ATOM
3186
C
ILE
A
221
74.509
−27.769
3.525
1.00
28.33
A
C


ATOM
3187
O
ILE
A
221
75.621
−28.265
3.366
1.00
28.37
A
O


ATOM
3189
N
GLU
A
222
74.165
−27.148
4.640
1.00
29.36
A
N


ATOM
3190
CA
GLU
A
222
75.089
−27.078
5.770
1.00
29.36
A
C


ATOM
3192
CB
GLU
A
222
74.540
−26.124
6.842
1.00
29.54
A
C


ATOM
3195
CG
GLU
A
222
75.301
−26.042
8.170
1.00
37.23
A
C


ATOM
3198
CD
GLU
A
222
76.756
−25.564
8.041
1.00
40.53
A
C


ATOM
3199
OE1
GLU
A
222
77.153
−25.010
6.984
1.00
44.11
A
O


ATOM
3200
OE2
GLU
A
222
77.499
−25.737
9.030
1.00
46.46
A
O


ATOM
3201
C
GLU
A
222
75.311
−28.503
6.286
1.00
29.13
A
C


ATOM
3202
O
GLU
A
222
76.438
−28.891
6.532
1.00
28.56
A
O


ATOM
3204
N
ALA
A
223
74.246
−29.305
6.379
1.00
28.23
A
N


ATOM
3205
CA
ALA
A
223
74.377
−30.670
6.882
1.00
27.59
A
C


ATOM
3207
CB
ALA
A
223
73.003
−31.344
7.026
1.00
29.69
A
C


ATOM
3211
C
ALA
A
223
75.255
−31.497
5.959
1.00
28.61
A
C


ATOM
3212
O
ALA
A
223
76.131
−32.225
6.420
1.00
28.90
A
O


ATOM
3214
N
TYR
A
224
74.995
−31.386
4.657
1.00
27.73
A
N


ATOM
3215
CA
TYR
A
224
75.677
−32.186
3.652
1.00
28.06
A
C


ATOM
3217
CB
TYR
A
224
75.020
−31.964
2.284
1.00
26.68
A
C


ATOM
3220
CG
TYR
A
224
75.272
−33.036
1.247
1.00
23.01
A
C


ATOM
3221
CD1
TYR
A
224
74.715
−34.296
1.372
1.00
24.54
A
C


ATOM
3223
CE1
TYR
A
224
74.929
−35.278
0.410
1.00
28.25
A
C


ATOM
3225
CZ
TYR
A
224
75.687
−34.995
−0.710
1.00
26.14
A
C


ATOM
3226
OH
TYR
A
224
75.902
−35.965
−1.669
1.00
30.14
A
O


ATOM
3228
CE2
TYR
A
224
76.244
−33.755
−0.859
1.00
24.49
A
C


ATOM
3230
CD2
TYR
A
224
76.030
−32.772
0.112
1.00
25.46
A
C


ATOM
3232
C
TYR
A
224
77.166
−31.809
3.607
1.00
28.75
A
C


ATOM
3233
O
TYR
A
224
78.029
−32.671
3.448
1.00
27.95
A
O


ATOM
3235
N
ARG
A
225
77.452
−30.525
3.769
1.00
29.70
A
N


ATOM
3236
CA
ARG
A
225
78.833
−30.042
3.733
1.00
34.37
A
C


ATOM
3238
CB
ARG
A
225
78.874
−28.525
3.945
1.00
34.39
A
C


ATOM
3241
CG
ARG
A
225
80.182
−27.914
3.518
1.00
42.08
A
C


ATOM
3244
CD
ARG
A
225
80.440
−26.599
4.201
1.00
44.17
A
C


ATOM
3247
NE
ARG
A
225
79.492
−25.587
3.768
1.00
33.41
A
N


ATOM
3249
CZ
ARG
A
225
79.757
−24.598
2.921
1.00
31.84
A
C


ATOM
3250
NH1
ARG
A
225
80.969
−24.440
2.360
1.00
26.16
A
N


ATOM
3253
NH2
ARG
A
225
78.789
−23.732
2.647
1.00
28.39
A
N


ATOM
3256
C
ARG
A
225
79.731
−30.720
4.782
1.00
34.95
A
C


ATOM
3257
O
ARG
A
225
80.924
−30.847
4.571
1.00
33.72
A
O


ATOM
3259
N
LYS
A
226
79.148
−31.153
5.897
1.00
38.87
A
N


ATOM
3260
CA
LYS
A
226
79.895
−31.805
6.980
1.00
41.98
A
C


ATOM
3262
CB
LYS
A
226
79.195
−31.585
8.323
1.00
41.81
A
C


ATOM
3265
CG
LYS
A
226
79.118
−30.139
8.760
1.00
43.92
A
C


ATOM
3268
CD
LYS
A
226
78.200
−30.008
9.967
1.00
48.86
A
C


ATOM
3271
CE
LYS
A
226
77.814
−28.571
10.214
1.00
50.51
A
C


ATOM
3274
NZ
LYS
A
226
76.638
−28.436
11.125
1.00
50.92
A
N


ATOM
3278
C
LYS
A
226
80.099
−33.305
6.780
1.00
43.06
A
C


ATOM
3279
O
LYS
A
226
80.952
−33.885
7.435
1.00
43.06
A
O


ATOM
3281
N
LYS
A
227
79.322
−33.938
5.905
1.00
44.99
A
N


ATOM
3282
CA
LYS
A
227
79.499
−35.372
5.641
1.00
46.76
A
C


ATOM
3284
CB
LYS
A
227
78.334
−35.933
4.840
1.00
46.98
A
C


ATOM
3287
CG
LYS
A
227
76.994
−35.858
5.523
1.00
51.16
A
C


ATOM
3290
CD
LYS
A
227
76.018
−36.864
4.900
1.00
58.14
A
C


ATOM
3293
CE
LYS
A
227
74.634
−36.793
5.566
1.00
65.96
A
C


ATOM
3296
NZ
LYS
A
227
74.529
−37.575
6.846
1.00
67.08
A
N


ATOM
3300
C
LYS
A
227
80.786
−35.607
4.854
1.00
48.34
A
C


ATOM
3301
O
LYS
A
227
80.992
−34.995
3.799
1.00
48.62
A
O


ATOM
3303
N
GLU
A
228
81.638
−36.503
5.359
1.00
49.33
A
N


ATOM
3304
CA
GLU
A
228
82.956
−36.761
4.757
1.00
49.51
A
C


ATOM
3306
CB
GLU
A
228
83.814
−37.641
5.689
1.00
50.88
A
C


ATOM
3309
CG
GLU
A
228
85.196
−38.038
5.113
1.00
58.59
A
C


ATOM
3312
CD
GLU
A
228
86.120
−38.742
6.127
1.00
63.27
A
C


ATOM
3313
OE1
GLU
A
228
86.715
−38.048
6.986
1.00
63.25
A
O


ATOM
3314
OE2
GLU
A
228
86.269
−39.985
6.040
1.00
60.49
A
O


ATOM
3315
C
GLU
A
228
82.839
−37.401
3.370
1.00
47.39
A
C


ATOM
3316
O
GLU
A
228
83.681
−37.153
2.503
1.00
48.29
A
O


ATOM
3318
N
ASP
A
229
81.792
−38.204
3.173
1.00
43.95
A
N


ATOM
3319
CA
ASP
A
229
81.528
−38.887
1.903
1.00
42.40
A
C


ATOM
3321
CB
ASP
A
229
81.004
−40.301
2.198
1.00
44.51
A
C


ATOM
3324
CG
ASP
A
229
79.635
−40.288
2.889
1.00
48.08
A
C


ATOM
3325
OD1
ASP
A
229
79.412
−39.414
3.764
1.00
52.32
A
O


ATOM
3326
OD2
ASP
A
229
78.791
−41.154
2.563
1.00
55.55
A
O


ATOM
3327
C
ASP
A
229
80.505
−38.161
1.001
1.00
39.47
A
C


ATOM
3328
O
ASP
A
229
79.905
−38.774
0.111
1.00
38.26
A
O


ATOM
3330
N
ALA
A
230
80.287
−36.871
1.232
1.00
35.85
A
N


ATOM
3331
CA
ALA
A
230
79.406
−36.089
0.360
1.00
34.54
A
C


ATOM
3333
CB
ALA
A
230
79.252
−34.654
0.911
1.00
34.43
A
C


ATOM
3337
C
ALA
A
230
79.943
−36.039
−1.075
1.00
31.71
A
C


ATOM
3338
O
ALA
A
230
81.139
−35.893
−1.293
1.00
31.71
A
O


ATOM
3340
N
ASN
A
231
79.052
−36.149
−2.048
1.00
30.30
A
N


ATOM
3341
CA
ASN
A
231
79.405
−35.899
−3.445
1.00
29.41
A
C


ATOM
3343
CB
ASN
A
231
78.209
−36.246
−4.341
1.00
28.84
A
C


ATOM
3346
CG
ASN
A
231
78.477
−36.010
−5.831
1.00
33.88
A
C


ATOM
3347
OD1
ASN
A
231
79.040
−34.979
−6.245
1.00
29.21
A
O


ATOM
3348
ND2
ASN
A
231
78.034
−36.955
−6.647
1.00
39.93
A
N


ATOM
3351
C
ASN
A
231
79.790
−34.424
−3.610
1.00
28.30
A
C


ATOM
3352
O
ASN
A
231
78.954
−33.553
−3.407
1.00
29.80
A
O


ATOM
3354
N
GLN
A
232
81.032
−34.144
−3.987
1.00
26.07
A
N


ATOM
3355
CA
GLN
A
232
81.501
−32.758
−4.080
1.00
26.86
A
C


ATOM
3357
CB
GLN
A
232
83.033
−32.713
−4.132
1.00
28.05
A
C


ATOM
3360
CG
GLN
A
232
83.748
−33.343
−2.907
1.00
32.80
A
C


ATOM
3363
CD
GLN
A
232
83.312
−32.742
−1.576
1.00
33.27
A
C


ATOM
3364
OE1
GLN
A
232
83.561
−31.573
−1.287
1.00
32.93
A
O


ATOM
3365
NE2
GLN
A
232
82.657
−33.550
−0.762
1.00
34.64
A
N


ATOM
3368
C
GLN
A
232
80.914
−31.962
−5.265
1.00
26.08
A
C


ATOM
3369
O
GLN
A
232
80.757
−30.731
−5.179
1.00
26.37
A
O


ATOM
3371
N
VAL
A
233
80.598
−32.647
−6.363
1.00
23.92
A
N


ATOM
3372
CA
VAL
A
233
79.939
−32.005
−7.513
1.00
23.21
A
C


ATOM
3374
CB
VAL
A
233
79.852
−32.957
−8.737
1.00
24.28
A
C


ATOM
3376
CG1
VAL
A
233
78.831
−32.450
−9.732
1.00
19.74
A
C


ATOM
3380
CG2
VAL
A
233
81.256
−33.115
−9.399
1.00
23.81
A
C


ATOM
3384
C
VAL
A
233
78.535
−31.501
−7.127
1.00
23.21
A
C


ATOM
3385
O
VAL
A
233
78.180
−30.351
−7.391
1.00
21.93
A
O


ATOM
3387
N
LEU
A
234
77.774
−32.344
−6.435
1.00
22.20
A
N


ATOM
3388
CA
LEU
A
234
76.438
−31.982
−5.981
1.00
22.67
A
C


ATOM
3390
CB
LEU
A
234
75.746
−33.221
−5.425
1.00
24.22
A
C


ATOM
3393
CG
LEU
A
234
74.276
−33.151
−4.995
1.00
25.50
A
C


ATOM
3395
CD1
LEU
A
234
73.370
−32.553
−6.102
1.00
18.15
A
C


ATOM
3399
CD2
LEU
A
234
73.833
−34.547
−4.622
1.00
18.42
A
C


ATOM
3403
C
LEU
A
234
76.469
−30.846
−4.941
1.00
23.82
A
C


ATOM
3404
O
LEU
A
234
75.701
−29.896
−5.041
1.00
24.91
A
O


ATOM
3406
N
LEU
A
235
77.374
−30.930
−3.966
1.00
23.57
A
N


ATOM
3407
CA
LEU
A
235
77.510
−29.892
−2.946
1.00
22.98
A
C


ATOM
3409
CB
LEU
A
235
78.597
−30.259
−1.944
1.00
24.41
A
C


ATOM
3412
CG
LEU
A
235
78.878
−29.265
−0.815
1.00
26.92
A
C


ATOM
3414
CD1
LEU
A
235
77.604
−29.078
0.019
1.00
15.89
A
C


ATOM
3418
CD2
LEU
A
235
80.061
−29.754
0.038
1.00
18.04
A
C


ATOM
3422
C
LEU
A
235
77.842
−28.566
−3.580
1.00
20.58
A
C


ATOM
3423
O
LEU
A
235
77.236
−27.545
−3.277
1.00
19.83
A
O


ATOM
3425
N
GLU
A
236
78.801
−28.572
−4.482
1.00
22.61
A
N


ATOM
3426
CA
GLU
A
236
79.170
−27.327
−5.122
1.00
22.75
A
C


ATOM
3428
CB
GLU
A
236
80.383
−27.502
−6.026
1.00
22.70
A
C


ATOM
3431
CG
GLU
A
236
80.871
−26.189
−6.606
1.00
23.04
A
C


ATOM
3434
CD
GLU
A
236
82.258
−26.245
−7.215
1.00
27.07
A
C


ATOM
3435
OE1
GLU
A
236
82.771
−27.340
−7.541
1.00
33.98
A
O


ATOM
3436
OE2
GLU
A
236
82.838
−25.154
−7.363
1.00
30.70
A
O


ATOM
3437
C
GLU
A
236
77.973
−26.757
−5.875
1.00
21.06
A
C


ATOM
3438
O
GLU
A
236
77.621
−25.602
−5.693
1.00
23.31
A
O


ATOM
3440
N
LEU
A
237
77.318
−27.567
−6.691
1.00
22.06
A
N


ATOM
3441
CA
LEU
A
237
76.183
−27.054
−7.480
1.00
19.57
A
C


ATOM
3443
CB
LEU
A
237
75.566
−28.155
−8.336
1.00
15.98
A
C


ATOM
3446
CG
LEU
A
237
74.366
−27.737
−9.187
1.00
15.57
A
C


ATOM
3448
CD1
LEU
A
237
74.786
−26.710
−10.243
1.00
14.06
A
C


ATOM
3452
CD2
LEU
A
237
73.740
−28.975
−9.837
1.00
15.04
A
C


ATOM
3456
C
LEU
A
237
75.133
−26.460
−6.562
1.00
19.31
A
C


ATOM
3457
O
LEU
A
237
74.608
−25.393
−6.820
1.00
20.86
A
O


ATOM
3459
N
ALA
A
238
74.846
−27.161
−5.474
1.00
19.04
A
N


ATOM
3460
CA
ALA
A
238
73.834
−26.739
−4.531
1.00
18.52
A
C


ATOM
3462
CB
ALA
A
238
73.675
−27.811
−3.413
1.00
18.25
A
C


ATOM
3466
C
ALA
A
238
74.193
−25.392
−3.927
1.00
19.60
A
C


ATOM
3467
O
ALA
A
238
73.350
−24.489
−3.794
1.00
21.50
A
O


ATOM
3469
N
ILE
A
239
75.448
−25.233
−3.539
1.00
19.28
A
N


ATOM
3470
CA
ILE
A
239
75.849
−23.943
−2.994
1.00
19.80
A
C


ATOM
3472
CB
ILE
A
239
77.274
−23.988
−2.476
1.00
20.00
A
C


ATOM
3474
CG1
ILE
A
239
77.319
−24.875
−1.218
1.00
17.31
A
C


ATOM
3477
CD1
ILE
A
239
78.704
−25.050
−0.668
1.00
21.36
A
C


ATOM
3481
CG2
ILE
A
239
77.786
−22.592
−2.202
1.00
17.51
A
C


ATOM
3485
C
ILE
A
239
75.665
−22.871
−4.062
1.00
20.41
A
C


ATOM
3486
O
ILE
A
239
75.042
−21.848
−3.806
1.00
19.36
A
O


ATOM
3488
N
LEU
A
240
76.198
−23.118
−5.258
1.00
21.30
A
N


ATOM
3489
CA
LEU
A
240
76.149
−22.135
−6.356
1.00
21.36
A
C


ATOM
3491
CB
LEU
A
240
76.776
−22.696
−7.645
1.00
22.81
A
C


ATOM
3494
CG
LEU
A
240
78.227
−22.426
−7.967
1.00
30.14
A
C


ATOM
3496
CD1
LEU
A
240
78.568
−23.128
−9.255
1.00
32.64
A
C


ATOM
3500
CD2
LEU
A
240
79.131
−22.906
−6.840
1.00
37.35
A
C


ATOM
3504
C
LEU
A
240
74.719
−21.794
−6.687
1.00
20.26
A
C


ATOM
3505
O
LEU
A
240
74.394
−20.648
−6.875
1.00
21.20
A
O


ATOM
3507
N
ASP
A
241
73.864
−22.806
−6.784
1.00
19.89
A
N


ATOM
3508
CA
ASP
A
241
72.482
−22.569
−7.156
1.00
20.98
A
C


ATOM
3510
CB
ASP
A
241
71.727
−23.866
−7.456
1.00
20.86
A
C


ATOM
3513
CG
ASP
A
241
70.487
−23.614
−8.317
1.00
26.59
A
C


ATOM
3514
OD1
ASP
A
241
69.370
−23.431
−7.778
1.00
23.99
A
O


ATOM
3515
OD2
ASP
A
241
70.638
−23.525
−9.538
1.00
24.62
A
O


ATOM
3516
C
ASP
A
241
71.741
−21.775
−6.091
1.00
21.28
A
C


ATOM
3517
O
ASP
A
241
70.980
−20.872
−6.411
1.00
22.40
A
O


ATOM
3519
N
TYR
A
242
71.967
−22.089
−4.828
1.00
20.15
A
N


ATOM
3520
CA
TYR
A
242
71.259
−21.393
−3.771
1.00
20.85
A
C


ATOM
3522
CB
TYR
A
242
71.568
−22.050
−2.438
1.00
22.45
A
C


ATOM
3525
CG
TYR
A
242
70.857
−21.437
−1.265
1.00
23.33
A
C


ATOM
3526
CD1
TYR
A
242
69.691
−21.998
−0.761
1.00
18.55
A
C


ATOM
3528
CE1
TYR
A
242
69.041
−21.418
0.330
1.00
24.47
A
C


ATOM
3530
CZ
TYR
A
242
69.569
−20.276
0.908
1.00
18.54
A
C


ATOM
3531
OH
TYR
A
242
68.956
−19.675
1.972
1.00
25.94
A
O


ATOM
3533
CE2
TYR
A
242
70.713
−19.709
0.406
1.00
21.27
A
C


ATOM
3535
CD2
TYR
A
242
71.346
−20.283
−0.666
1.00
19.29
A
C


ATOM
3537
C
TYR
A
242
71.620
−19.907
−3.718
1.00
22.79
A
C


ATOM
3538
O
TYR
A
242
70.727
−19.047
−3.526
1.00
22.49
A
O


ATOM
3540
N
ASN
A
243
72.912
−19.603
−3.864
1.00
20.76
A
N


ATOM
3541
CA
ASN
A
243
73.375
−18.205
−3.845
1.00
22.06
A
C


ATOM
3543
CB
ASN
A
243
74.906
−18.124
−3.672
1.00
20.78
A
C


ATOM
3546
CG
ASN
A
243
75.349
−18.533
−2.275
1.00
25.87
A
C


ATOM
3547
OD1
ASN
A
243
74.529
−18.590
−1.347
1.00
27.54
A
O


ATOM
3548
ND2
ASN
A
243
76.639
−18.815
−2.110
1.00
19.91
A
N


ATOM
3551
C
ASN
A
243
72.933
−17.409
−5.066
1.00
21.72
A
C


ATOM
3552
O
ASN
A
243
72.662
−16.203
−4.983
1.00
22.95
A
O


ATOM
3554
N
MET
A
244
72.846
−18.070
−6.205
1.00
21.84
A
N


ATOM
3555
CA
MET
A
244
72.301
−17.412
−7.384
1.00
23.63
A
C


ATOM
3557
CB
MET
A
244
72.478
−18.316
−8.582
1.00
23.14
A
C


ATOM
3560
CG
MET
A
244
71.729
−17.885
−9.801
1.00
25.17
A
C


ATOM
3563
SD
MET
A
244
71.520
−19.311
−10.849
1.00
37.78
A
S


ATOM
3564
CE
MET
A
244
70.066
−20.130
−10.156
1.00
36.34
A
C


ATOM
3568
C
MET
A
244
70.810
−17.060
−7.194
1.00
24.55
A
C


ATOM
3569
O
MET
A
244
70.367
−15.958
−7.524
1.00
27.20
A
O


ATOM
3571
N
ILE
A
245
70.029
−17.988
−6.665
1.00
23.34
A
N


ATOM
3572
CA
ILE
A
245
68.612
−17.708
−6.487
1.00
23.03
A
C


ATOM
3574
CB
ILE
A
245
67.828
−18.961
−6.067
1.00
23.79
A
C


ATOM
3576
CG1
ILE
A
245
67.753
−19.935
−7.251
1.00
24.90
A
C


ATOM
3579
CD1
ILE
A
245
67.053
−21.262
−6.934
1.00
20.17
A
C


ATOM
3583
CG2
ILE
A
245
66.428
−18.579
−5.537
1.00
18.88
A
C


ATOM
3587
C
ILE
A
245
68.452
−16.565
−5.475
1.00
22.27
A
C


ATOM
3588
O
ILE
A
245
67.673
−15.646
−5.689
1.00
23.18
A
O


ATOM
3590
N
GLN
A
246
69.222
−16.618
−4.400
1.00
21.78
A
N


ATOM
3591
CA
GLN
A
246
69.201
−15.585
−3.385
1.00
22.32
A
C


ATOM
3593
CB
GLN
A
246
70.192
−15.913
−2.267
1.00
22.29
A
C


ATOM
3596
CG
GLN
A
246
70.105
−14.977
−1.079
1.00
22.47
A
C


ATOM
3599
CD
GLN
A
246
71.193
−15.238
−0.086
1.00
23.64
A
C


ATOM
3600
OE1
GLN
A
246
72.333
−14.876
−0.330
1.00
30.86
A
O


ATOM
3601
NE2
GLN
A
246
70.855
−15.897
1.046
1.00
27.00
A
N


ATOM
3604
C
GLN
A
246
69.519
−14.220
−3.969
1.00
25.79
A
C


ATOM
3605
O
GLN
A
246
68.906
−13.227
−3.574
1.00
28.66
A
O


ATOM
3607
N
SER
A
247
70.448
−14.156
−4.918
1.00
24.24
A
N


ATOM
3608
CA
SER
A
247
70.741
−12.881
−5.566
1.00
25.76
A
C


ATOM
3610
CB
SER
A
247
71.984
−12.957
−6.460
1.00
25.65
A
C


ATOM
3613
OG
SER
A
247
71.670
−13.655
−7.661
1.00
32.02
A
O


ATOM
3615
C
SER
A
247
69.557
−12.390
−6.377
1.00
24.68
A
C


ATOM
3616
O
SER
A
247
69.434
−11.184
−6.615
1.00
26.69
A
O


ATOM
3618
N
VAL
A
248
68.700
−13.295
−6.833
1.00
23.54
A
N


ATOM
3619
CA
VAL
A
248
67.456
−12.855
−7.466
1.00
23.71
A
C


ATOM
3621
CB
VAL
A
248
66.766
−13.966
−8.265
1.00
26.06
A
C


ATOM
3623
CG1
VAL
A
248
65.435
−13.455
−8.867
1.00
19.39
A
C


ATOM
3627
CG2
VAL
A
248
67.716
−14.472
−9.386
1.00
23.18
A
C


ATOM
3631
C
VAL
A
248
66.521
−12.281
−6.398
1.00
25.20
A
C


ATOM
3632
O
VAL
A
248
65.871
−11.268
−6.617
1.00
28.02
A
O


ATOM
3634
N
TYR
A
249
66.482
−12.898
−5.231
1.00
23.81
A
N


ATOM
3635
CA
TYR
A
249
65.652
−12.372
−4.165
1.00
27.09
A
C


ATOM
3637
CB
TYR
A
249
65.642
−13.297
−2.919
1.00
27.78
A
C


ATOM
3640
CG
TYR
A
249
65.127
−14.716
−3.122
1.00
22.87
A
C


ATOM
3641
CD1
TYR
A
249
64.358
−15.066
−4.225
1.00
20.29
A
C


ATOM
3643
CE1
TYR
A
249
63.892
−16.351
−4.383
1.00
20.19
A
C


ATOM
3645
CZ
TYR
A
249
64.185
−17.292
−3.431
1.00
24.01
A
C


ATOM
3646
OH
TYR
A
249
63.731
−18.576
−3.586
1.00
21.28
A
O


ATOM
3648
CE2
TYR
A
249
64.938
−16.969
−2.329
1.00
17.32
A
C


ATOM
3650
CD2
TYR
A
249
65.402
−15.698
−2.185
1.00
22.81
A
C


ATOM
3652
C
TYR
A
249
66.152
−10.995
−3.752
1.00
28.26
A
C


ATOM
3653
O
TYR
A
249
65.361
−10.086
−3.502
1.00
28.96
A
O


ATOM
3655
N
GLN
A
250
67.470
−10.835
−3.655
1.00
30.13
A
N


ATOM
3656
CA
GLN
A
250
68.017
−9.558
−3.209
1.00
29.19
A
C


ATOM
3658
CB
GLN
A
250
69.523
−9.646
−2.980
1.00
29.25
A
C


ATOM
3661
CG
GLN
A
250
69.842
−10.420
−1.714
1.00
27.79
A
C


ATOM
3664
CD
GLN
A
250
71.234
−11.016
−1.662
1.00
32.54
A
C


ATOM
3665
OE1
GLN
A
250
72.048
−10.868
−2.584
1.00
30.29
A
O


ATOM
3666
NE2
GLN
A
250
71.510
−11.717
−0.573
1.00
28.97
A
N


ATOM
3669
C
GLN
A
250
67.616
−8.450
−4.174
1.00
29.47
A
C


ATOM
3670
O
GLN
A
250
67.253
−7.356
−3.727
1.00
30.74
A
O


ATOM
3672
N
ARG
A
251
67.600
−8.748
−5.471
1.00
29.60
A
N


ATOM
3673
CA
ARG
A
251
67.112
−7.789
−6.465
1.00
30.89
A
C


ATOM
3675
CB
ARG
A
251
67.463
−8.185
−7.905
1.00
32.50
A
C


ATOM
3678
CG
ARG
A
251
67.113
−7.073
−8.936
1.00
40.34
A
C


ATOM
3681
CD
ARG
A
251
67.748
−7.272
−10.319
1.00
50.67
A
C


ATOM
3684
NE
ARG
A
251
67.564
−8.647
−10.781
1.00
60.70
A
N


ATOM
3686
CZ
ARG
A
251
68.526
−9.565
−10.909
1.00
68.22
A
C


ATOM
3687
NH1
ARG
A
251
69.808
−9.281
−10.650
1.00
66.48
A
N


ATOM
3690
NH2
ARG
A
251
68.200
−10.793
−11.318
1.00
67.68
A
N


ATOM
3693
C
ARG
A
251
65.621
−7.568
−6.373
1.00
30.00
A
C


ATOM
3694
O
ARG
A
251
65.156
−6.438
−6.483
1.00
31.03
A
O


ATOM
3696
N
ASP
A
252
64.855
−8.637
−6.197
1.00
29.66
A
N


ATOM
3697
CA
ASP
A
252
63.422
−8.487
−6.004
1.00
27.76
A
C


ATOM
3699
CB
ASP
A
252
62.766
−9.838
−5.688
1.00
28.05
A
C


ATOM
3702
CG
ASP
A
252
62.734
−10.802
−6.881
1.00
31.72
A
C


ATOM
3703
OD1
ASP
A
252
62.980
−10.396
−8.039
1.00
32.65
A
O


ATOM
3704
OD2
ASP
A
252
62.453
−11.998
−6.635
1.00
31.73
A
O


ATOM
3705
C
ASP
A
252
63.149
−7.507
−4.849
1.00
27.28
A
C


ATOM
3706
O
ASP
A
252
62.343
−6.590
−4.965
1.00
28.15
A
O


ATOM
3708
N
LEU
A
253
63.831
−7.709
−3.738
1.00
28.14
A
N


ATOM
3709
CA
LEU
A
253
63.621
−6.912
−2.539
1.00
29.87
A
C


ATOM
3711
CB
LEU
A
253
64.347
−7.566
−1.372
1.00
29.41
A
C


ATOM
3714
CG
LEU
A
253
64.118
−6.971
−0.001
1.00
34.75
A
C


ATOM
3716
CD1
LEU
A
253
62.630
−6.934
0.321
1.00
26.24
A
C


ATOM
3720
CD2
LEU
A
253
64.893
−7.766
1.038
1.00
36.83
A
C


ATOM
3724
C
LEU
A
253
64.071
−5.451
−2.681
1.00
31.45
A
C


ATOM
3725
O
LEU
A
253
63.406
−4.547
−2.168
1.00
32.50
A
O


ATOM
3727
N
ARG
A
254
65.180
−5.203
−3.364
1.00
33.17
A
N


ATOM
3728
CA
ARG
A
254
65.632
−3.810
−3.557
1.00
34.97
A
C


ATOM
3730
CB
ARG
A
254
66.973
−3.726
−4.297
1.00
35.48
A
C


ATOM
3733
CG
ARG
A
254
68.190
−3.919
−3.399
1.00
40.57
A
C


ATOM
3736
CD
ARG
A
254
69.493
−3.551
−4.113
1.00
42.70
A
C


ATOM
3739
NE
ARG
A
254
69.666
−4.290
−5.366
1.00
42.33
A
N


ATOM
3741
CZ
ARG
A
254
70.190
−5.516
−5.483
1.00
43.80
A
C


ATOM
3742
NH1
ARG
A
254
70.619
−6.197
−4.422
1.00
40.69
A
N


ATOM
3745
NH2
ARG
A
254
70.293
−6.067
−6.689
1.00
45.83
A
N


ATOM
3748
C
ARG
A
254
64.563
−3.054
−4.316
1.00
34.14
A
C


ATOM
3749
O
ARG
A
254
64.154
−1.977
−3.915
1.00
35.76
A
O


ATOM
3751
N
GLU
A
255
64.096
−3.667
−5.390
1.00
34.42
A
N


ATOM
3752
CA
GLU
A
255
63.024
−3.139
−6.221
1.00
36.63
A
C


ATOM
3754
CB
GLU
A
255
62.724
−4.179
−7.296
1.00
38.74
A
C


ATOM
3757
CG
GLU
A
255
61.825
−3.773
−8.455
1.00
50.85
A
C


ATOM
3760
CD
GLU
A
255
61.681
−4.909
−9.497
1.00
60.07
A
C


ATOM
3761
OE1
GLU
A
255
62.720
−5.463
−9.957
1.00
60.17
A
O


ATOM
3762
OE2
GLU
A
255
60.523
−5.246
−9.844
1.00
63.55
A
O


ATOM
3763
C
GLU
A
255
61.756
−2.831
−5.420
1.00
36.27
A
C


ATOM
3764
O
GLU
A
255
61.129
−1.794
−5.593
1.00
39.35
A
O


ATOM
3766
N
THR
A
256
61.383
−3.739
−4.539
1.00
33.73
A
N


ATOM
3767
CA
THR
A
256
60.151
−3.622
−3.790
1.00
31.80
A
C


ATOM
3769
CB
THR
A
256
59.703
−5.018
−3.323
1.00
30.64
A
C


ATOM
3771
OG1
THR
A
256
59.309
−5.757
−4.469
1.00
33.76
A
O


ATOM
3773
CG2
THR
A
256
58.537
−4.966
−2.325
1.00
32.44
A
C


ATOM
3777
C
THR
A
256
60.360
−2.667
−2.618
1.00
30.31
A
C


ATOM
3778
O
THR
A
256
59.460
−1.916
−2.260
1.00
29.39
A
O


ATOM
3780
N
SER
A
257
61.544
−2.705
−2.022
1.00
30.11
A
N


ATOM
3781
CA
SER
A
257
61.920
−1.693
−1.036
1.00
33.18
A
C


ATOM
3783
CB
SER
A
257
63.327
−1.943
−0.475
1.00
32.22
A
C


ATOM
3786
OG
SER
A
257
63.336
−3.128
0.297
1.00
33.34
A
O


ATOM
3788
C
SER
A
257
61.834
−0.281
−1.621
1.00
33.22
A
C


ATOM
3789
O
SER
A
257
61.449
0.638
−0.907
1.00
33.37
A
O


ATOM
3791
N
ARG
A
258
62.173
−0.111
−2.901
1.00
32.43
A
N


ATOM
3792
CA
ARG
A
258
62.019
1.204
−3.565
1.00
35.63
A
C


ATOM
3794
CB
ARG
A
258
62.525
1.207
−5.024
1.00
38.19
A
C


ATOM
3797
CG
ARG
A
258
63.974
1.629
−5.235
1.00
43.51
A
C


ATOM
3800
CD
ARG
A
258
64.204
2.128
−6.670
1.00
49.21
A
C


ATOM
3803
NE
ARG
A
258
63.874
1.127
−7.692
1.00
50.92
A
N


ATOM
3805
CZ
ARG
A
258
64.697
0.173
−8.133
1.00
57.27
A
C


ATOM
3806
NH1
ARG
A
258
64.275
−0.679
−9.060
1.00
57.78
A
N


ATOM
3809
NH2
ARG
A
258
65.935
0.050
−7.653
1.00
60.74
A
N


ATOM
3812
C
ARG
A
258
60.571
1.623
−3.602
1.00
33.91
A
C


ATOM
3813
O
ARG
A
258
60.254
2.753
−3.318
1.00
33.23
A
O


ATOM
3815
N
TRP
A
259
59.697
0.714
−4.015
1.00
33.11
A
N


ATOM
3816
CA
TRP
A
259
58.266
1.003
−4.026
1.00
32.00
A
C


ATOM
3818
CB
TRP
A
259
57.487
−0.183
−4.587
1.00
31.64
A
C


ATOM
3821
CG
TRP
A
259
56.053
−0.155
−4.267
1.00
27.92
A
C


ATOM
3822
CD1
TRP
A
259
55.084
0.569
−4.900
1.00
32.00
A
C


ATOM
3824
NE1
TRP
A
259
53.861
0.357
−4.299
1.00
30.37
A
N


ATOM
3826
CE2
TRP
A
259
54.033
−0.523
−3.264
1.00
26.02
A
C


ATOM
3827
CD2
TRP
A
259
55.400
−0.861
−3.211
1.00
28.92
A
C


ATOM
3828
CE3
TRP
A
259
55.839
−1.732
−2.212
1.00
24.22
A
C


ATOM
3830
CZ3
TRP
A
259
54.932
−2.229
−1.337
1.00
28.49
A
C


ATOM
3832
CH2
TRP
A
259
53.584
−1.882
−1.425
1.00
32.67
A
C


ATOM
3834
CZ2
TRP
A
259
53.125
−1.025
−2.382
1.00
22.99
A
C


ATOM
3836
C
TRP
A
259
57.753
1.358
−2.623
1.00
31.98
A
C


ATOM
3837
O
TRP
A
259
56.957
2.274
−2.465
1.00
34.30
A
O


ATOM
3839
N
TRP
A
260
58.224
0.639
−1.611
1.00
30.69
A
N


ATOM
3840
CA
TRP
A
260
57.676
0.755
−0.270
1.00
29.45
A
C


ATOM
3842
CB
TRP
A
260
58.190
−0.399
0.578
1.00
29.19
A
C


ATOM
3845
CG
TRP
A
260
57.621
−0.512
1.985
1.00
32.70
A
C


ATOM
3846
CD1
TRP
A
260
58.333
−0.569
3.137
1.00
31.86
A
C


ATOM
3848
NE1
TRP
A
260
57.489
−0.698
4.209
1.00
33.52
A
N


ATOM
3850
CE2
TRP
A
260
56.202
−0.741
3.762
1.00
27.99
A
C


ATOM
3851
CD2
TRP
A
260
56.240
−0.627
2.364
1.00
25.33
A
C


ATOM
3852
CE3
TRP
A
260
55.038
−0.632
1.658
1.00
28.45
A
C


ATOM
3854
CZ3
TRP
A
260
53.863
−0.755
2.356
1.00
24.24
A
C


ATOM
3856
CH2
TRP
A
260
53.859
−0.875
3.741
1.00
29.24
A
C


ATOM
3858
CZ2
TRP
A
260
55.017
−0.858
4.466
1.00
31.81
A
C


ATOM
3860
C
TRP
A
260
58.052
2.102
0.332
1.00
29.67
A
C


ATOM
3861
O
TRP
A
260
57.218
2.763
0.934
1.00
26.76
A
O


ATOM
3863
N
ARG
A
261
59.288
2.528
0.111
1.00
32.87
A
N


ATOM
3864
CA
AARG
A
261
59.778
3.810
0.630
0.50
35.92
A
C


ATOM
3865
CA
BARG
A
261
59.768
3.809
0.649
0.50
35.98
A
C


ATOM
3868
CB
AARG
A
261
61.299
3.917
0.447
0.50
36.14
A
C


ATOM
3869
CB
BARG
A
261
61.293
3.938
0.514
0.50
36.20
A
C


ATOM
3874
CG
AARG
A
261
62.081
3.255
1.576
0.50
40.00
A
C


ATOM
3875
CG
BARG
A
261
61.962
4.656
1.691
0.50
40.66
A
C


ATOM
3880
CD
AARG
A
261
63.347
2.553
1.086
0.50
45.53
A
C


ATOM
3881
CD
BARG
A
261
61.787
3.877
3.002
0.50
44.00
A
C


ATOM
3886
NE
AARG
A
261
63.970
3.229
−0.049
0.50
45.59
A
N


ATOM
3887
NE
BARG
A
261
62.789
4.234
4.005
0.50
45.46
A
N


ATOM
3890
CZ
AARG
A
261
64.845
2.643
−0.856
0.50
42.15
A
C


ATOM
3891
CZ
BARG
A
261
62.660
5.236
4.869
0.50
50.02
A
C


ATOM
3892
NH1
AARG
A
261
65.188
1.382
−0.637
0.50
33.28
A
N


ATOM
3893
NH1
BARG
A
261
61.567
5.987
4.861
0.50
49.40
A
N


ATOM
3898
NH2
AARG
A
261
65.370
3.311
−1.874
0.50
42.47
A
N


ATOM
3899
NH2
BARG
A
261
63.625
5.484
5.745
0.50
49.02
A
N


ATOM
3904
C
ARG
A
261
59.061
4.997
−0.024
1.00
37.61
A
C


ATOM
3905
O
ARG
A
261
58.729
5.981
0.642
1.00
38.28
A
O


ATOM
3907
N
ARG
A
262
58.808
4.897
−1.327
1.00
38.01
A
N


ATOM
3908
CA
ARG
A
262
58.026
5.922
−2.019
1.00
39.29
A
C


ATOM
3910
CB
ARG
A
262
57.878
5.607
−3.516
1.00
42.22
A
C


ATOM
3913
CG
ARG
A
262
59.136
5.898
−4.350
1.00
52.27
A
C


ATOM
3916
CD
ARG
A
262
58.787
6.242
−5.811
1.00
62.63
A
C


ATOM
3919
NE
ARG
A
262
57.884
5.261
−6.428
1.00
67.61
A
N


ATOM
3921
CZ
ARG
A
262
58.273
4.146
−7.054
1.00
71.86
A
C


ATOM
3922
NH1
ARG
A
262
59.567
3.837
−7.171
1.00
69.63
A
N


ATOM
3925
NH2
ARG
A
262
57.354
3.328
−7.566
1.00
71.10
A
N


ATOM
3928
C
ARG
A
262
56.646
6.038
−1.398
1.00
35.13
A
C


ATOM
3929
O
ARG
A
262
56.192
7.127
−1.072
1.00
39.41
A
O


ATOM
3931
N
VAL
A
263
55.978
4.913
−1.229
1.00
31.29
A
N


ATOM
3932
CA
VAL
A
263
54.684
4.899
−0.577
1.00
28.48
A
C


ATOM
3934
CB
VAL
A
263
54.116
3.501
−0.518
1.00
26.56
A
C


ATOM
3936
CG1
VAL
A
263
53.801
3.029
−1.925
1.00
30.17
A
C


ATOM
3940
CG2
VAL
A
263
52.879
3.480
0.354
1.00
27.85
A
C


ATOM
3944
C
VAL
A
263
54.745
5.479
0.844
1.00
28.20
A
C


ATOM
3945
O
VAL
A
263
53.801
6.150
1.259
1.00
26.93
A
O


ATOM
3947
N
GLY
A
264
55.847
5.199
1.559
1.00
28.31
A
N


ATOM
3948
CA
GLY
A
264
56.160
5.750
2.871
1.00
27.54
A
C


ATOM
3951
C
GLY
A
264
55.063
5.691
3.909
1.00
29.80
A
C


ATOM
3952
O
GLY
A
264
54.978
6.560
4.760
1.00
32.57
A
O


ATOM
3954
N
LEU
A
265
54.219
4.673
3.842
1.00
32.96
A
N


ATOM
3955
CA
LEU
A
265
53.026
4.593
4.679
1.00
36.19
A
C


ATOM
3957
CB
LEU
A
265
52.050
3.553
4.111
1.00
34.50
A
C


ATOM
3960
CG
LEU
A
265
50.568
3.516
4.505
1.00
36.39
A
C


ATOM
3962
CD1
LEU
A
265
49.833
4.834
4.299
1.00
27.01
A
C


ATOM
3966
CD2
LEU
A
265
49.858
2.406
3.721
1.00
31.32
A
C


ATOM
3970
C
LEU
A
265
53.376
4.316
6.151
1.00
40.47
A
C


ATOM
3971
O
LEU
A
265
52.828
4.964
7.046
1.00
41.90
A
O


ATOM
3973
N
ALA
A
266
54.306
3.402
6.413
1.00
45.05
A
N


ATOM
3974
CA
ALA
A
266
54.692
3.097
7.803
1.00
48.60
A
C


ATOM
3976
CB
ALA
A
266
55.536
1.834
7.871
1.00
49.61
A
C


ATOM
3980
C
ALA
A
266
55.414
4.263
8.486
1.00
50.25
A
C


ATOM
3981
O
ALA
A
266
55.437
4.354
9.709
1.00
53.50
A
O


ATOM
3983
N
THR
A
267
55.989
5.161
7.693
1.00
51.71
A
N


ATOM
3984
CA
THR
A
267
56.599
6.383
8.220
1.00
50.87
A
C


ATOM
3986
CB
THR
A
267
57.494
7.042
7.158
1.00
50.67
A
C


ATOM
3988
OG1
THR
A
267
58.268
6.030
6.501
1.00
54.33
A
O


ATOM
3990
CG2
THR
A
267
58.420
8.057
7.783
1.00
53.96
A
C


ATOM
3994
C
THR
A
267
55.537
7.383
8.678
1.00
49.72
A
C


ATOM
3995
O
THR
A
267
55.657
7.966
9.753
1.00
51.35
A
O


ATOM
3997
N
LYS
A
268
54.494
7.567
7.870
1.00
47.73
A
N


ATOM
3998
CA
LYS
A
268
53.515
8.655
8.074
1.00
45.94
A
C


ATOM
4000
CB
LYS
A
268
52.935
9.113
6.720
1.00
46.30
A
C


ATOM
4003
CG
LYS
A
268
53.986
9.658
5.725
1.00
47.05
A
C


ATOM
4006
CD
LYS
A
268
54.376
11.104
6.011
1.00
49.29
A
C


ATOM
4009
CE
LYS
A
268
55.573
11.543
5.161
1.00
52.85
A
C


ATOM
4012
NZ
LYS
A
268
55.780
13.020
5.207
1.00
54.81
A
N


ATOM
4016
C
LYS
A
268
52.378
8.275
9.024
1.00
44.32
A
C


ATOM
4017
O
LYS
A
268
51.749
9.148
9.610
1.00
44.98
A
O


ATOM
4019
N
LEU
A
269
52.095
6.980
9.138
1.00
43.49
A
N


ATOM
4020
CA
LEU
A
269
51.151
6.457
10.122
1.00
43.04
A
C


ATOM
4022
CB
LEU
A
269
50.429
5.222
9.561
1.00
42.92
A
C


ATOM
4025
CG
LEU
A
269
49.100
5.381
8.814
1.00
42.16
A
C


ATOM
4027
CD1
LEU
A
269
49.147
6.491
7.813
1.00
38.88
A
C


ATOM
4031
CD2
LEU
A
269
48.721
4.062
8.144
1.00
40.39
A
C


ATOM
4035
C
LEU
A
269
51.943
6.068
11.380
1.00
43.46
A
C


ATOM
4036
O
LEU
A
269
52.741
5.132
11.344
1.00
45.75
A
O


ATOM
4038
N
HIS
A
270
51.718
6.762
12.489
1.00
42.57
A
N


ATOM
4039
CA
HIS
A
270
52.559
6.585
13.689
1.00
42.20
A
C


ATOM
4041
CB
HIS
A
270
52.334
7.730
14.706
1.00
43.68
A
C


ATOM
4044
CG
HIS
A
270
52.315
9.101
14.088
1.00
55.54
A
C


ATOM
4045
ND1
HIS
A
270
53.195
9.489
13.097
1.00
59.69
A
N


ATOM
4047
CE1
HIS
A
270
52.936
10.737
12.746
1.00
62.20
A
C


ATOM
4049
NE2
HIS
A
270
51.925
11.177
13.475
1.00
61.94
A
N


ATOM
4051
CD2
HIS
A
270
51.515
10.173
14.321
1.00
61.38
A
C


ATOM
4053
C
HIS
A
270
52.340
5.224
14.372
1.00
37.82
A
C


ATOM
4054
O
HIS
A
270
53.221
4.720
15.063
1.00
35.89
A
O


ATOM
4056
N
PHE
A
271
51.160
4.649
14.178
1.00
34.74
A
N


ATOM
4057
CA
PHE
A
271
50.818
3.349
14.756
1.00
35.98
A
C


ATOM
4059
CB
PHE
A
271
49.297
3.246
14.975
1.00
36.24
A
C


ATOM
4062
CG
PHE
A
271
48.513
3.176
13.700
1.00
32.72
A
C


ATOM
4063
CD1
PHE
A
271
48.245
1.962
13.107
1.00
36.61
A
C


ATOM
4065
CE1
PHE
A
271
47.542
1.895
11.905
1.00
41.78
A
C


ATOM
4067
CZ
PHE
A
271
47.106
3.050
11.293
1.00
39.23
A
C


ATOM
4069
CE2
PHE
A
271
47.370
4.267
11.868
1.00
40.49
A
C


ATOM
4071
CD2
PHE
A
271
48.081
4.330
13.072
1.00
36.58
A
C


ATOM
4073
C
PHE
A
271
51.277
2.144
13.928
1.00
36.24
A
C


ATOM
4074
O
PHE
A
271
51.232
1.028
14.425
1.00
36.55
A
O


ATOM
4076
N
ALA
A
272
51.705
2.352
12.681
1.00
36.36
A
N


ATOM
4077
CA
ALA
A
272
51.905
1.217
11.753
1.00
38.44
A
C


ATOM
4079
CB
ALA
A
272
51.767
1.683
10.299
1.00
37.11
A
C


ATOM
4083
C
ALA
A
272
53.235
0.493
11.939
1.00
37.87
A
C


ATOM
4084
O
ALA
A
272
54.260
1.128
12.126
1.00
38.46
A
O


ATOM
4086
N
ARG
A
273
53.199
−0.838
11.895
1.00
39.95
A
N


ATOM
4087
CA
ARG
A
273
54.415
−1.651
11.843
1.00
42.71
A
C


ATOM
4089
CB
ARG
A
273
54.161
−3.077
12.354
1.00
44.71
A
C


ATOM
4092
CG
ARG
A
273
53.612
−3.232
13.785
1.00
52.26
A
C


ATOM
4095
CD
ARG
A
273
53.137
−4.699
14.060
1.00
58.75
A
C


ATOM
4098
NE
ARG
A
273
51.872
−5.018
13.384
1.00
59.61
A
N


ATOM
4100
CZ
ARG
A
273
51.440
−6.241
13.062
1.00
65.74
A
C


ATOM
4101
NH1
ARG
A
273
52.168
−7.320
13.327
1.00
72.19
A
N


ATOM
4104
NH2
ARG
A
273
50.268
−6.390
12.441
1.00
62.91
A
N


ATOM
4107
C
ARG
A
273
54.886
−1.731
10.387
1.00
41.28
A
C


ATOM
4108
O
ARG
A
273
54.067
−1.896
9.486
1.00
42.18
A
O


ATOM
4110
N
ASP
A
274
56.195
−1.605
10.171
1.00
40.00
A
N


ATOM
4111
CA
ASP
A
274
56.819
−1.798
8.854
1.00
38.76
A
C


ATOM
4113
CB
ASP
A
274
57.983
−0.808
8.684
1.00
38.55
A
C


ATOM
4116
CG
ASP
A
274
58.733
−0.993
7.370
1.00
42.03
A
C


ATOM
4117
OD1
ASP
A
274
58.666
−2.086
6.781
1.00
39.25
A
O


ATOM
4118
OD2
ASP
A
274
59.404
−0.044
6.918
1.00
46.81
A
O


ATOM
4119
C
ASP
A
274
57.306
−3.260
8.725
1.00
37.31
A
C


ATOM
4120
O
ASP
A
274
58.281
−3.644
9.349
1.00
36.99
A
O


ATOM
4122
N
ARG
A
275
56.612
−4.069
7.925
1.00
37.37
A
N


ATOM
4123
CA
ARG
A
275
56.889
−5.498
7.826
1.00
37.69
A
C


ATOM
4125
CB
ARG
A
275
55.702
−6.299
8.391
1.00
39.25
A
C


ATOM
4128
CG
ARG
A
275
55.490
−6.180
9.913
1.00
47.84
A
C


ATOM
4131
CD
ARG
A
275
56.044
−7.381
10.697
1.00
59.27
A
C


ATOM
4134
NE
ARG
A
275
55.924
−7.187
12.150
1.00
68.25
A
N


ATOM
4136
CZ
ARG
A
275
56.679
−6.355
12.886
1.00
74.47
A
C


ATOM
4137
NH1
ARG
A
275
57.641
−5.618
12.324
1.00
74.61
A
N


ATOM
4140
NH2
ARG
A
275
56.473
−6.252
14.204
1.00
72.98
A
N


ATOM
4143
C
ARG
A
275
57.168
−5.943
6.388
1.00
36.06
A
C


ATOM
4144
O
ARG
A
275
56.729
−7.017
5.973
1.00
35.65
A
O


ATOM
4146
N
LEU
A
276
57.898
−5.137
5.623
1.00
35.38
A
N


ATOM
4147
CA
LEU
A
276
58.209
−5.505
4.231
1.00
34.05
A
C


ATOM
4149
CB
LEU
A
276
58.824
−4.340
3.438
1.00
35.05
A
C


ATOM
4152
CG
LEU
A
276
59.320
−4.741
2.049
1.00
34.24
A
C


ATOM
4154
CD1
LEU
A
276
58.157
−5.203
1.208
1.00
37.51
A
C


ATOM
4158
CD2
LEU
A
276
60.030
−3.629
1.374
1.00
37.66
A
C


ATOM
4162
C
LEU
A
276
59.147
−6.698
4.170
1.00
31.37
A
C


ATOM
4163
O
LEU
A
276
58.890
−7.636
3.443
1.00
30.37
A
O


ATOM
4165
N
ILE
A
277
60.221
−6.664
4.950
1.00
30.01
A
N


ATOM
4166
CA
ILE
A
277
61.242
−7.701
4.870
1.00
29.44
A
C


ATOM
4168
CB
ILE
A
277
62.459
−7.360
5.755
1.00
30.70
A
C


ATOM
4170
CG1
ILE
A
277
63.124
−6.061
5.253
1.00
35.07
A
C


ATOM
4173
CD1
ILE
A
277
64.038
−5.345
6.291
1.00
36.73
A
C


ATOM
4177
CG2
ILE
A
277
63.463
−8.487
5.705
1.00
27.89
A
C


ATOM
4181
C
ILE
A
277
60.654
−9.045
5.267
1.00
28.92
A
C


ATOM
4182
O
ILE
A
277
60.847
−10.054
4.583
1.00
28.83
A
O


ATOM
4184
N
GLU
A
278
59.905
−9.048
6.359
1.00
27.84
A
N


ATOM
4185
CA
GLU
A
278
59.220
−10.244
6.818
1.00
29.71
A
C


ATOM
4187
CB
GLU
A
278
58.538
−9.966
8.161
1.00
30.64
A
C


ATOM
4190
CG
GLU
A
278
59.515
−9.600
9.291
1.00
41.88
A
C


ATOM
4193
CD
GLU
A
278
59.736
−8.097
9.493
1.00
50.18
A
C


ATOM
4194
OE1
GLU
A
278
59.920
−7.333
8.508
1.00
48.05
A
O


ATOM
4195
OE2
GLU
A
278
59.742
−7.686
10.673
1.00
59.82
A
O


ATOM
4196
C
GLU
A
278
58.197
−10.733
5.761
1.00
28.62
A
C


ATOM
4197
O
GLU
A
278
58.066
−11.929
5.519
1.00
28.77
A
O


ATOM
4199
N
SER
A
279
57.509
−9.791
5.114
1.00
25.67
A
N


ATOM
4200
CA
SER
A
279
56.510
−10.111
4.115
1.00
25.01
A
C


ATOM
4202
CB
SER
A
279
55.694
−8.869
3.762
1.00
26.35
A
C


ATOM
4205
OG
SER
A
279
54.839
−8.541
4.839
1.00
32.90
A
O


ATOM
4207
C
SER
A
279
57.152
−10.682
2.875
1.00
24.05
A
C


ATOM
4208
O
SER
A
279
56.560
−11.514
2.223
1.00
23.50
A
O


ATOM
4210
N
PHE
A
280
58.365
−10.237
2.551
1.00
21.71
A
N


ATOM
4211
CA
PHE
A
280
59.091
−10.801
1.419
1.00
23.37
A
C


ATOM
4213
CB
PHE
A
280
60.266
−9.902
1.017
1.00
25.01
A
C


ATOM
4216
CG
PHE
A
280
60.841
−10.261
−0.298
1.00
22.72
A
C


ATOM
4217
CD1
PHE
A
280
60.259
−9.812
−1.466
1.00
26.45
A
C


ATOM
4219
CE1
PHE
A
280
60.747
−10.180
−2.677
1.00
25.95
A
C


ATOM
4221
CZ
PHE
A
280
61.836
−11.022
−2.737
1.00
25.35
A
C


ATOM
4223
CE2
PHE
A
280
62.415
−11.486
−1.584
1.00
24.77
A
C


ATOM
4225
CD2
PHE
A
280
61.917
−11.108
−0.370
1.00
26.82
A
C


ATOM
4227
C
PHE
A
280
59.599
−12.226
1.709
1.00
23.03
A
C


ATOM
4228
O
PHE
A
280
59.491
−13.103
0.863
1.00
25.85
A
O


ATOM
4230
N
TYR
A
281
60.156
−12.429
2.896
1.00
23.11
A
N


ATOM
4231
CA
TYR
A
281
60.546
−13.751
3.392
1.00
24.07
A
C


ATOM
4233
CB
TYR
A
281
61.140
−13.640
4.806
1.00
24.19
A
C


ATOM
4236
CG
TYR
A
281
61.313
−14.958
5.545
1.00
26.46
A
C


ATOM
4237
CD1
TYR
A
281
62.469
−15.728
5.401
1.00
28.95
A
C


ATOM
4239
CE1
TYR
A
281
62.607
−16.960
6.070
1.00
32.82
A
C


ATOM
4241
CZ
TYR
A
281
61.584
−17.403
6.899
1.00
23.73
A
C


ATOM
4242
OH
TYR
A
281
61.699
−18.572
7.602
1.00
37.06
A
O


ATOM
4244
CE2
TYR
A
281
60.463
−16.627
7.091
1.00
27.38
A
C


ATOM
4246
CD2
TYR
A
281
60.336
−15.409
6.424
1.00
28.38
A
C


ATOM
4248
C
TYR
A
281
59.327
−14.681
3.339
1.00
23.90
A
C


ATOM
4249
O
TYR
A
281
59.407
−15.778
2.841
1.00
22.03
A
O


ATOM
4251
N
TRP
A
282
58.178
−14.190
3.769
1.00
24.19
A
N


ATOM
4252
CA
TRP
A
282
56.946
−14.940
3.645
1.00
23.89
A
C


ATOM
4254
CB
TRP
A
282
55.772
−14.098
4.127
1.00
24.11
A
C


ATOM
4257
CG
TRP
A
282
54.466
−14.809
4.037
1.00
24.19
A
C


ATOM
4258
CD1
TRP
A
282
53.597
−14.786
2.998
1.00
22.17
A
C


ATOM
4260
NE1
TRP
A
282
52.491
−15.562
3.279
1.00
24.03
A
N


ATOM
4262
CE2
TRP
A
282
52.657
−16.120
4.518
1.00
27.44
A
C


ATOM
4263
CD2
TRP
A
282
53.888
−15.656
5.029
1.00
23.48
A
C


ATOM
4264
CE3
TRP
A
282
54.291
−16.075
6.296
1.00
29.21
A
C


ATOM
4266
CZ3
TRP
A
282
53.470
−16.930
7.001
1.00
30.47
A
C


ATOM
4268
CH2
TRP
A
282
52.255
−17.363
6.468
1.00
29.72
A
C


ATOM
4270
CZ2
TRP
A
282
51.830
−16.962
5.233
1.00
25.51
A
C


ATOM
4272
C
TRP
A
282
56.717
−15.400
2.195
1.00
24.21
A
C


ATOM
4273
O
TRP
A
282
56.504
−16.587
1.947
1.00
22.03
A
O


ATOM
4275
N
ALA
A
283
56.806
−14.455
1.259
1.00
22.23
A
N


ATOM
4276
CA
ALA
A
283
56.573
−14.706
−0.165
1.00
20.96
A
C


ATOM
4278
CB
ALA
A
283
56.663
−13.402
−0.961
1.00
18.60
A
C


ATOM
4282
C
ALA
A
283
57.522
−15.728
−0.781
1.00
21.39
A
C


ATOM
4283
O
ALA
A
283
57.118
−16.474
−1.679
1.00
20.52
A
O


ATOM
4285
N
VAL
A
284
58.769
−15.754
−0.318
1.00
22.30
A
N


ATOM
4286
CA
VAL
A
284
59.758
−16.758
−0.764
1.00
23.58
A
C


ATOM
4288
CB
VAL
A
284
61.144
−16.478
−0.111
1.00
24.57
A
C


ATOM
4290
CG1
VAL
A
284
61.727
−15.180
−0.672
1.00
19.22
A
C


ATOM
4294
CG2
VAL
A
284
62.095
−17.641
−0.320
1.00
19.35
A
C


ATOM
4298
C
VAL
A
284
59.302
−18.202
−0.456
1.00
24.32
A
C


ATOM
4299
O
VAL
A
284
59.566
−19.151
−1.208
1.00
23.82
A
O


ATOM
4301
N
GLY
A
285
58.599
−18.369
0.649
1.00
24.47
A
N


ATOM
4302
CA
GLY
A
285
57.973
−19.648
0.958
1.00
21.25
A
C


ATOM
4305
C
GLY
A
285
56.907
−20.048
−0.031
1.00
20.54
A
C


ATOM
4306
O
GLY
A
285
56.745
−21.226
−0.300
1.00
22.10
A
O


ATOM
4308
N
VAL
A
286
56.162
−19.078
−0.547
1.00
22.33
A
N


ATOM
4309
CA
VAL
A
286
55.029
−19.347
−1.441
1.00
20.31
A
C


ATOM
4311
CB
VAL
A
286
54.045
−18.169
−1.463
1.00
23.35
A
C


ATOM
4313
CG1
VAL
A
286
52.961
−18.408
−2.468
1.00
22.65
A
C


ATOM
4317
CG2
VAL
A
286
53.388
−17.973
−0.051
1.00
22.60
A
C


ATOM
4321
C
VAL
A
286
55.529
−19.659
−2.834
1.00
22.01
A
C


ATOM
4322
O
VAL
A
286
55.056
−20.605
−3.472
1.00
22.74
A
O


ATOM
4324
N
ALA
A
287
56.540
−18.915
−3.279
1.00
21.32
A
N


ATOM
4325
CA
ALA
A
287
57.034
−19.003
−4.629
1.00
20.30
A
C


ATOM
4327
CB
ALA
A
287
56.297
−17.991
−5.503
1.00
21.67
A
C


ATOM
4331
C
ALA
A
287
58.540
−18.779
−4.678
1.00
23.56
A
C


ATOM
4332
O
ALA
A
287
59.038
−17.632
−4.868
1.00
25.80
A
O


ATOM
4334
N
PHE
A
288
59.286
−19.860
−4.502
1.00
21.24
A
N


ATOM
4335
CA
PHE
A
288
60.720
−19.748
−4.348
1.00
22.02
A
C


ATOM
4337
CB
PHE
A
288
61.254
−20.872
−3.493
1.00
22.68
A
C


ATOM
4340
CG
PHE
A
288
61.372
−22.180
−4.225
1.00
26.97
A
C


ATOM
4341
CD1
PHE
A
288
62.541
−22.512
−4.885
1.00
31.37
A
C


ATOM
4343
CE1
PHE
A
288
62.649
−23.713
−5.570
1.00
35.11
A
C


ATOM
4345
CZ
PHE
A
288
61.587
−24.584
−5.596
1.00
29.46
A
C


ATOM
4347
CE2
PHE
A
288
60.415
−24.273
−4.937
1.00
33.40
A
C


ATOM
4349
CD2
PHE
A
288
60.310
−23.067
−4.255
1.00
33.76
A
C


ATOM
4351
C
PHE
A
288
61.451
−19.743
−5.697
1.00
26.03
A
C


ATOM
4352
O
PHE
A
288
62.568
−19.226
−5.784
1.00
25.19
A
O


ATOM
4354
N
GLU
A
289
60.836
−20.322
−6.734
1.00
27.65
A
N


ATOM
4355
CA
GLU
A
289
61.515
−20.489
−8.023
1.00
30.57
A
C


ATOM
4357
CB
GLU
A
289
60.643
−21.265
−9.023
1.00
32.76
A
C


ATOM
4360
CG
GLU
A
289
60.270
−22.716
−8.620
1.00
35.64
A
C


ATOM
4363
CD
GLU
A
289
58.926
−22.861
−7.872
1.00
42.73
A
C


ATOM
4364
OE1
GLU
A
289
58.488
−21.920
−7.160
1.00
37.11
A
O


ATOM
4365
OE2
GLU
A
289
58.306
−23.949
−8.008
1.00
42.82
A
O


ATOM
4366
C
GLU
A
289
61.916
−19.123
−8.599
1.00
30.30
A
C


ATOM
4367
O
GLU
A
289
61.153
−18.141
−8.491
1.00
29.03
A
O


ATOM
4369
N
PRO
A
290
63.115
−19.049
−9.204
1.00
28.09
A
N


ATOM
4370
CA
PRO
A
290
63.664
−17.754
−9.554
1.00
29.01
A
C


ATOM
4372
CB
PRO
A
290
65.013
−18.089
−10.205
1.00
29.11
A
C


ATOM
4375
CG
PRO
A
290
64.972
−19.515
−10.485
1.00
29.92
A
C


ATOM
4378
CD
PRO
A
290
64.059
−20.129
−9.491
1.00
29.29
A
C


ATOM
4381
C
PRO
A
290
62.789
−16.958
−10.500
1.00
28.51
A
C


ATOM
4382
O
PRO
A
290
62.732
−15.737
−10.385
1.00
28.65
A
O


ATOM
4383
N
GLN
A
291
62.099
−17.650
−11.397
1.00
27.75
A
N


ATOM
4384
CA
GLN
A
291
61.250
−16.998
−12.382
1.00
28.53
A
C


ATOM
4386
CB
GLN
A
291
60.845
−17.961
−13.519
1.00
27.02
A
C


ATOM
4389
CG
GLN
A
291
59.893
−19.074
−13.155
1.00
31.90
A
C


ATOM
4392
CD
GLN
A
291
60.583
−20.284
−12.532
1.00
38.40
A
C


ATOM
4393
OE1
GLN
A
291
61.709
−20.183
−12.037
1.00
39.73
A
O


ATOM
4394
NE2
GLN
A
291
59.911
−21.449
−12.576
1.00
32.16
A
N


ATOM
4397
C
GLN
A
291
59.993
−16.369
−11.795
1.00
29.44
A
C


ATOM
4398
O
GLN
A
291
59.343
−15.592
−12.496
1.00
31.07
A
O


ATOM
4400
N
TYR
A
292
59.633
−16.690
−10.547
1.00
28.42
A
N


ATOM
4401
CA
TYR
A
292
58.398
−16.147
−9.951
1.00
27.91
A
C


ATOM
4403
CB
TYR
A
292
57.733
−17.182
−9.046
1.00
30.21
A
C


ATOM
4406
CG
TYR
A
292
57.131
−18.402
−9.740
1.00
31.70
A
C


ATOM
4407
CD1
TYR
A
292
56.502
−18.299
−10.975
1.00
31.99
A
C


ATOM
4409
CE1
TYR
A
292
55.951
−19.407
−11.591
1.00
39.31
A
C


ATOM
4411
CZ
TYR
A
292
55.999
−20.641
−10.970
1.00
38.20
A
C


ATOM
4412
OH
TYR
A
292
55.441
−21.716
−11.596
1.00
45.03
A
O


ATOM
4414
CE2
TYR
A
292
56.601
−20.781
−9.735
1.00
42.05
A
C


ATOM
4416
CD2
TYR
A
292
57.166
−19.663
−9.126
1.00
39.69
A
C


ATOM
4418
C
TYR
A
292
58.594
−14.816
−9.182
1.00
28.53
A
C


ATOM
4419
O
TYR
A
292
57.989
−14.590
−8.118
1.00
25.90
A
O


ATOM
4421
N
SER
A
293
59.398
−13.916
−9.747
1.00
28.30
A
N


ATOM
4422
CA
SER
A
293
59.641
−12.601
−9.135
1.00
28.09
A
C


ATOM
4424
CB
SER
A
293
60.602
−11.763
−10.009
1.00
29.47
A
C


ATOM
4427
OG
SER
A
293
61.965
−11.924
−9.592
1.00
29.79
A
O


ATOM
4429
C
SER
A
293
58.352
−11.808
−8.874
1.00
28.45
A
C


ATOM
4430
O
SER
A
293
58.189
−11.199
−7.805
1.00
28.09
A
O


ATOM
4432
N
ASP
A
294
57.449
−11.808
−9.855
1.00
26.88
A
N


ATOM
4433
CA
ASP
A
294
56.223
−11.048
−9.784
1.00
25.77
A
C


ATOM
4435
CB
ASP
A
294
55.461
−11.124
−11.117
1.00
28.17
A
C


ATOM
4438
CG
ASP
A
294
56.157
−10.395
−12.248
1.00
34.74
A
C


ATOM
4439
OD1
ASP
A
294
56.956
−9.462
−12.000
1.00
36.83
A
O


ATOM
4440
OD2
ASP
A
294
55.888
−10.765
−13.412
1.00
45.26
A
O


ATOM
4441
C
ASP
A
294
55.313
−11.591
−8.684
1.00
28.84
A
C


ATOM
4442
O
ASP
A
294
54.585
−10.823
−8.009
1.00
29.14
A
O


ATOM
4444
N
CYS
A
295
55.322
−12.912
−8.517
1.00
26.55
A
N


ATOM
4445
CA
CYS
A
295
54.540
−13.511
−7.464
1.00
27.07
A
C


ATOM
4447
CB
CYS
A
295
54.524
−15.043
−7.567
1.00
28.06
A
C


ATOM
4450
SG
CYS
A
295
53.328
−15.810
−6.436
1.00
26.81
A
S


ATOM
4452
C
CYS
A
295
55.044
−13.060
−6.100
1.00
25.39
A
C


ATOM
4453
O
CYS
A
295
54.254
−12.597
−5.284
1.00
26.37
A
O


ATOM
4455
N
ARG
A
296
56.345
−13.169
−5.861
1.00
24.67
A
N


ATOM
4456
CA
ARG
A
296
56.923
−12.732
−4.592
1.00
24.65
A
C


ATOM
4458
CB
ARG
A
296
58.437
−12.963
−4.543
1.00
25.23
A
C


ATOM
4461
CG
ARG
A
296
58.835
−14.418
−4.502
1.00
22.91
A
C


ATOM
4464
CD
ARG
A
296
60.318
−14.618
−4.304
1.00
19.82
A
C


ATOM
4467
NE
ARG
A
296
61.076
−14.305
−5.507
1.00
19.18
A
N


ATOM
4469
CZ
ARG
A
296
61.223
−15.096
−6.561
1.00
22.17
A
C


ATOM
4470
NH1
ARG
A
296
60.647
−16.274
−6.620
1.00
26.97
A
N


ATOM
4473
NH2
ARG
A
296
61.933
−14.676
−7.592
1.00
26.83
A
N


ATOM
4476
C
ARG
A
296
56.651
−11.249
−4.321
1.00
24.07
A
C


ATOM
4477
O
ARG
A
296
56.264
−10.893
−3.221
1.00
24.88
A
O


ATOM
4479
N
ASN
A
297
56.849
−10.408
−5.325
1.00
23.19
A
N


ATOM
4480
CA
ASN
A
297
56.624
−8.982
−5.192
1.00
24.62
A
C


ATOM
4482
CB
ASN
A
297
57.063
−8.215
−6.463
1.00
25.20
A
C


ATOM
4485
CG
ASN
A
297
58.598
−8.235
−6.676
1.00
30.05
A
C


ATOM
4486
OD1
ASN
A
297
59.359
−8.502
−5.753
1.00
36.93
A
O


ATOM
4487
ND2
ASN
A
297
59.039
−7.959
−7.903
1.00
25.92
A
N


ATOM
4490
C
ASN
A
297
55.152
−8.696
−4.866
1.00
24.78
A
C


ATOM
4491
O
ASN
A
297
54.871
−7.960
−3.926
1.00
22.91
A
O


ATOM
4493
N
SER
A
298
54.236
−9.305
−5.613
1.00
23.57
A
N


ATOM
4494
CA
SER
A
298
52.813
−9.173
−5.338
1.00
25.11
A
C


ATOM
4496
CB
SER
A
298
51.968
−10.060
−6.272
1.00
24.10
A
C


ATOM
4499
OG
SER
A
298
51.678
−9.429
−7.493
1.00
32.64
A
O


ATOM
4501
C
SER
A
298
52.475
−9.579
−3.916
1.00
22.38
A
C


ATOM
4502
O
SER
A
298
51.809
−8.846
−3.192
1.00
24.02
A
O


ATOM
4504
N
VAL
A
299
52.857
−10.791
−3.552
1.00
21.05
A
N


ATOM
4505
CA
VAL
A
299
52.520
−11.321
−2.237
1.00
20.22
A
C


ATOM
4507
CB
VAL
A
299
52.949
−12.794
−2.091
1.00
20.34
A
C


ATOM
4509
CG1
VAL
A
299
52.838
−13.258
−0.650
1.00
22.69
A
C


ATOM
4513
CG2
VAL
A
299
52.089
−13.647
−2.954
1.00
18.14
A
C


ATOM
4517
C
VAL
A
299
53.124
−10.468
−1.133
1.00
19.72
A
C


ATOM
4518
O
VAL
A
299
52.466
−10.220
−0.122
1.00
21.66
A
O


ATOM
4520
N
ALA
A
300
54.342
−9.970
−1.342
1.00
19.58
A
N


ATOM
4521
CA
ALA
A
300
55.011
−9.150
−0.320
1.00
21.43
A
C


ATOM
4523
CB
ALA
A
300
56.486
−8.987
−0.667
1.00
19.80
A
C


ATOM
4527
C
ALA
A
300
54.339
−7.779
−0.181
1.00
21.64
A
C


ATOM
4528
O
ALA
A
300
54.232
−7.202
0.922
1.00
21.71
A
O


ATOM
4530
N
LYS
A
301
53.872
−7.255
−1.303
1.00
22.14
A
N


ATOM
4531
CA
LYS
A
301
53.204
−5.964
−1.281
1.00
21.36
A
C


ATOM
4533
CB
LYS
A
301
52.984
−5.439
−2.690
1.00
20.86
A
C


ATOM
4536
CG
LYS
A
301
54.236
−4.921
−3.366
1.00
19.27
A
C


ATOM
4539
CD
LYS
A
301
53.965
−4.388
−4.792
1.00
19.50
A
C


ATOM
4542
CE
LYS
A
301
55.276
−3.879
−5.400
1.00
29.29
A
C


ATOM
4545
NZ
LYS
A
301
55.116
−3.235
−6.741
1.00
34.09
A
N


ATOM
4549
C
LYS
A
301
51.879
−6.131
−0.548
1.00
21.48
A
C


ATOM
4550
O
LYS
A
301
51.540
−5.352
0.338
1.00
22.68
A
O


ATOM
4552
N
MET
A
302
51.160
−7.192
−0.878
1.00
20.39
A
N


ATOM
4553
CA
MET
A
302
49.849
−7.409
−0.282
1.00
20.92
A
C


ATOM
4555
CB
MET
A
302
49.133
−8.583
−0.969
1.00
20.09
A
C


ATOM
4558
CG
MET
A
302
48.712
−8.266
−2.405
1.00
19.65
A
C


ATOM
4561
SD
MET
A
302
47.843
−6.709
−2.587
1.00
28.88
A
S


ATOM
4562
CE
MET
A
302
49.185
−5.629
−3.034
1.00
23.45
A
C


ATOM
4566
C
MET
A
302
49.937
−7.677
1.199
1.00
22.54
A
C


ATOM
4567
O
MET
A
302
49.185
−7.097
1.998
1.00
24.84
A
O


ATOM
4569
N
PHE
A
303
50.861
−8.551
1.579
1.00
22.29
A
N


ATOM
4570
CA
PHE
A
303
51.019
−8.862
2.982
1.00
22.99
A
C


ATOM
4572
CB
PHE
A
303
51.984
−10.050
3.159
1.00
25.28
A
C


ATOM
4575
CG
PHE
A
303
51.716
−10.891
4.387
1.00
30.30
A
C


ATOM
4576
CD1
PHE
A
303
50.589
−10.683
5.192
1.00
34.42
A
C


ATOM
4578
CE1
PHE
A
303
50.371
−11.460
6.324
1.00
42.97
A
C


ATOM
4580
CZ
PHE
A
303
51.274
−12.459
6.657
1.00
41.14
A
C


ATOM
4582
CE2
PHE
A
303
52.381
−12.678
5.871
1.00
34.43
A
C


ATOM
4584
CD2
PHE
A
303
52.599
−11.899
4.741
1.00
36.11
A
C


ATOM
4586
C
PHE
A
303
51.455
−7.625
3.816
1.00
21.77
A
C


ATOM
4587
O
PHE
A
303
51.033
−7.464
4.938
1.00
23.38
A
O


ATOM
4589
N
SER
A
304
52.270
−6.755
3.244
1.00
20.77
A
N


ATOM
4590
CA
SER
A
304
52.648
−5.517
3.876
1.00
21.72
A
C


ATOM
4592
CB
SER
A
304
53.638
−4.750
2.997
1.00
24.31
A
C


ATOM
4595
OG
SER
A
304
54.847
−5.480
2.795
1.00
28.25
A
O


ATOM
4597
C
SER
A
304
51.440
−4.622
4.150
1.00
23.63
A
C


ATOM
4598
O
SER
A
304
51.387
−4.005
5.212
1.00
24.50
A
O


ATOM
4600
N
PHE
A
305
50.497
−4.541
3.205
1.00
23.27
A
N


ATOM
4601
CA
PHE
A
305
49.230
−3.804
3.424
1.00
21.89
A
C


ATOM
4603
CB
PHE
A
305
48.466
−3.560
2.113
1.00
22.71
A
C


ATOM
4606
CG
PHE
A
305
48.938
−2.345
1.368
1.00
20.52
A
C


ATOM
4607
CD1
PHE
A
305
48.659
−1.073
1.850
1.00
24.16
A
C


ATOM
4609
CE1
PHE
A
305
49.097
0.050
1.181
1.00
23.31
A
C


ATOM
4611
CZ
PHE
A
305
49.826
−0.078
0.013
1.00
23.43
A
C


ATOM
4613
CE2
PHE
A
305
50.120
−1.337
−0.478
1.00
29.03
A
C


ATOM
4615
CD2
PHE
A
305
49.682
−2.469
0.219
1.00
22.45
A
C


ATOM
4617
C
PHE
A
305
48.313
−4.499
4.393
1.00
20.95
A
C


ATOM
4618
O
PHE
A
305
47.674
−3.849
5.226
1.00
20.99
A
O


ATOM
4620
N
VAL
A
306
48.255
−5.821
4.309
1.00
20.76
A
N


ATOM
4621
CA
VAL
A
306
47.434
−6.575
5.229
1.00
19.75
A
C


ATOM
4623
CB
VAL
A
306
47.506
−8.080
4.963
1.00
22.66
A
C


ATOM
4625
CG1
VAL
A
306
46.885
−8.886
6.091
1.00
16.37
A
C


ATOM
4629
CG2
VAL
A
306
46.790
−8.388
3.645
1.00
21.60
A
C


ATOM
4633
C
VAL
A
306
47.823
−6.224
6.636
1.00
22.33
A
C


ATOM
4634
O
VAL
A
306
46.962
−5.861
7.435
1.00
24.20
A
O


ATOM
4636
N
THR
A
307
49.108
−6.225
6.945
1.00
24.63
A
N


ATOM
4637
CA
THR
A
307
49.502
−6.040
8.344
1.00
26.20
A
C


ATOM
4639
CB
THR
A
307
51.009
−6.313
8.570
1.00
26.67
A
C


ATOM
4641
OG1
THR
A
307
51.771
−5.398
7.828
1.00
36.85
A
O


ATOM
4643
CG2
THR
A
307
51.386
−7.698
8.106
1.00
31.58
A
C


ATOM
4647
C
THR
A
307
49.092
−4.669
8.895
1.00
25.04
A
C


ATOM
4648
O
THR
A
307
48.668
−4.547
10.049
1.00
26.45
A
O


ATOM
4650
N
ILE
A
308
49.172
−3.647
8.060
1.00
23.77
A
N


ATOM
4651
CA
ILE
A
308
48.761
−2.299
8.445
1.00
23.18
A
C


ATOM
4653
CB
ILE
A
308
49.219
−1.270
7.409
1.00
24.44
A
C


ATOM
4655
CG1
ILE
A
308
50.742
−1.206
7.371
1.00
29.53
A
C


ATOM
4658
CD1
ILE
A
308
51.267
−0.355
6.265
1.00
30.91
A
C


ATOM
4662
CG2
ILE
A
308
48.639
0.078
7.714
1.00
23.42
A
C


ATOM
4666
C
ILE
A
308
47.252
−2.223
8.554
1.00
20.59
A
C


ATOM
4667
O
ILE
A
308
46.723
−1.650
9.506
1.00
20.09
A
O


ATOM
4669
N
ILE
A
309
46.551
−2.802
7.585
1.00
20.24
A
N


ATOM
4670
CA
ILE
A
309
45.093
−2.712
7.594
1.00
22.80
A
C


ATOM
4672
CB
ILE
A
309
44.466
−3.173
6.284
1.00
24.10
A
C


ATOM
4674
CG1
ILE
A
309
44.927
−2.279
5.128
1.00
25.79
A
C


ATOM
4677
CD1
ILE
A
309
44.234
−1.018
5.079
1.00
37.61
A
C


ATOM
4681
CG2
ILE
A
309
42.941
−3.162
6.360
1.00
17.79
A
C


ATOM
4685
C
ILE
A
309
44.584
−3.521
8.777
1.00
23.44
A
C


ATOM
4686
O
ILE
A
309
43.626
−3.118
9.447
1.00
23.95
A
O


ATOM
4688
N
ASP
A
310
45.278
−4.617
9.076
1.00
24.85
A
N


ATOM
4689
CA
ASP
A
310
44.942
−5.453
10.226
1.00
25.67
A
C


ATOM
4691
CB
ASP
A
310
45.823
−6.716
10.278
1.00
29.93
A
C


ATOM
4694
CG
ASP
A
310
45.316
−7.775
11.294
1.00
34.30
A
C


ATOM
4695
OD1
ASP
A
310
44.106
−7.830
11.573
1.00
46.69
A
O


ATOM
4696
OD2
ASP
A
310
46.139
−8.566
11.790
1.00
50.27
A
O


ATOM
4697
C
ASP
A
310
45.084
−4.658
11.501
1.00
23.92
A
C


ATOM
4698
O
ASP
A
310
44.202
−4.696
12.344
1.00
23.74
A
O


ATOM
4700
N
ASP
A
311
46.167
−3.903
11.648
1.00
23.61
A
N


ATOM
4701
CA
ASP
A
311
46.302
−3.063
12.840
1.00
24.15
A
C


ATOM
4703
CB
ASP
A
311
47.653
−2.346
12.864
1.00
25.79
A
C


ATOM
4706
CG
ASP
A
311
48.811
−3.283
13.157
1.00
33.35
A
C


ATOM
4707
OD1
ASP
A
311
48.578
−4.327
13.802
1.00
37.00
A
O


ATOM
4708
OD2
ASP
A
311
49.951
−2.976
12.720
1.00
42.12
A
O


ATOM
4709
C
ASP
A
311
45.185
−2.013
12.963
1.00
22.01
A
C


ATOM
4710
O
ASP
A
311
44.750
−1.689
14.066
1.00
20.06
A
O


ATOM
4712
N
ILE
A
312
44.738
−1.486
11.827
1.00
20.61
A
N


ATOM
4713
CA
ILE
A
312
43.693
−0.467
11.814
1.00
20.98
A
C


ATOM
4715
CB
ILE
A
312
43.462
0.111
10.392
1.00
20.72
A
C


ATOM
4717
CG1
ILE
A
312
44.605
1.043
10.000
1.00
19.24
A
C


ATOM
4720
CD1
ILE
A
312
44.576
1.481
8.508
1.00
18.67
A
C


ATOM
4724
CG2
ILE
A
312
42.163
0.844
10.337
1.00
17.52
A
C


ATOM
4728
C
ILE
A
312
42.403
−1.049
12.373
1.00
21.29
A
C


ATOM
4729
O
ILE
A
312
41.781
−0.462
13.259
1.00
22.89
A
O


ATOM
4731
N
TYR
A
313
42.036
−2.232
11.905
1.00
21.99
A
N


ATOM
4732
CA
TYR
A
313
40.816
−2.852
12.362
1.00
22.07
A
C


ATOM
4734
CB
TYR
A
313
40.395
−3.962
11.408
1.00
21.44
A
C


ATOM
4737
CG
TYR
A
313
39.668
−3.483
10.187
1.00
17.68
A
C


ATOM
4738
CD1
TYR
A
313
38.273
−3.567
10.095
1.00
17.60
A
C


ATOM
4740
CE1
TYR
A
313
37.601
−3.157
8.927
1.00
18.93
A
C


ATOM
4742
CZ
TYR
A
313
38.333
−2.642
7.866
1.00
20.93
A
C


ATOM
4743
OH
TYR
A
313
37.713
−2.225
6.703
1.00
21.19
A
O


ATOM
4745
CE2
TYR
A
313
39.705
−2.556
7.953
1.00
21.64
A
C


ATOM
4747
CD2
TYR
A
313
40.361
−2.958
9.111
1.00
20.65
A
C


ATOM
4749
C
TYR
A
313
40.929
−3.399
13.761
1.00
24.20
A
C


ATOM
4750
O
TYR
A
313
39.957
−3.362
14.526
1.00
25.90
A
O


ATOM
4752
N
ASP
A
314
42.119
−3.872
14.108
1.00
26.32
A
N


ATOM
4753
CA
ASP
A
314
42.339
−4.552
15.395
1.00
27.33
A
C


ATOM
4755
CB
ASP
A
314
43.622
−5.398
15.321
1.00
29.31
A
C


ATOM
4758
CG
ASP
A
314
43.891
−6.217
16.598
1.00
33.13
A
C


ATOM
4759
OD1
ASP
A
314
42.985
−6.889
17.107
1.00
38.25
A
O


ATOM
4760
OD2
ASP
A
314
45.038
−6.219
17.065
1.00
42.87
A
O


ATOM
4761
C
ASP
A
314
42.415
−3.565
16.560
1.00
25.83
A
C


ATOM
4762
O
ASP
A
314
41.786
−3.798
17.589
1.00
24.11
A
O


ATOM
4764
N
VAL
A
315
43.168
−2.469
16.419
1.00
25.13
A
N


ATOM
4765
CA
VAL
A
315
43.388
−1.571
17.581
1.00
23.81
A
C


ATOM
4767
CB
VAL
A
315
44.803
−1.707
18.175
1.00
24.08
A
C


ATOM
4769
CG1
VAL
A
315
44.920
−3.047
18.917
1.00
27.01
A
C


ATOM
4773
CG2
VAL
A
315
45.876
−1.542
17.111
1.00
18.89
A
C


ATOM
4777
C
VAL
A
315
43.121
−0.091
17.390
1.00
24.28
A
C


ATOM
4778
O
VAL
A
315
42.626
0.550
18.316
1.00
25.60
A
O


ATOM
4780
N
TYR
A
316
43.452
0.454
16.218
1.00
23.17
A
N


ATOM
4781
CA
TYR
A
316
43.463
1.888
16.012
1.00
22.03
A
C


ATOM
4783
CB
TYR
A
316
44.468
2.250
14.921
1.00
24.42
A
C


ATOM
4786
CG
TYR
A
316
44.780
3.741
14.847
1.00
24.19
A
C


ATOM
4787
CD1
TYR
A
316
45.669
4.330
15.734
1.00
22.67
A
C


ATOM
4789
CE1
TYR
A
316
45.956
5.710
15.664
1.00
26.80
A
C


ATOM
4791
CZ
TYR
A
316
45.343
6.487
14.689
1.00
23.98
A
C


ATOM
4792
OH
TYR
A
316
45.616
7.825
14.594
1.00
23.58
A
O


ATOM
4794
CE2
TYR
A
316
44.462
5.915
13.802
1.00
27.54
A
C


ATOM
4796
CD2
TYR
A
316
44.188
4.553
13.880
1.00
23.46
A
C


ATOM
4798
C
TYR
A
316
42.109
2.489
15.659
1.00
21.60
A
C


ATOM
4799
O
TYR
A
316
41.709
3.471
16.256
1.00
21.67
A
O


ATOM
4801
N
GLY
A
317
41.407
1.917
14.684
1.00
22.29
A
N


ATOM
4802
CA
GLY
A
317
40.150
2.510
14.186
1.00
21.66
A
C


ATOM
4805
C
GLY
A
317
38.877
2.302
15.016
1.00
22.48
A
C


ATOM
4806
O
GLY
A
317
38.613
1.212
15.566
1.00
20.21
A
O


ATOM
4808
N
THR
A
318
38.050
3.335
15.090
1.00
21.00
A
N


ATOM
4809
CA
THR
A
318
36.756
3.163
15.737
1.00
22.14
A
C


ATOM
4811
CB
THR
A
318
36.126
4.472
16.125
1.00
20.46
A
C


ATOM
4813
OG1
THR
A
318
35.835
5.197
14.935
1.00
20.90
A
O


ATOM
4815
CG2
THR
A
318
37.073
5.280
17.008
1.00
21.19
A
C


ATOM
4819
C
THR
A
318
35.844
2.436
14.759
1.00
21.63
A
C


ATOM
4820
O
THR
A
318
36.110
2.395
13.550
1.00
21.76
A
O


ATOM
4822
N
LEU
A
319
34.777
1.864
15.297
1.00
20.18
A
N


ATOM
4823
CA
LEU
A
319
33.830
1.067
14.514
1.00
22.24
A
C


ATOM
4825
CB
LEU
A
319
32.701
0.551
15.416
1.00
22.04
A
C


ATOM
4828
CG
LEU
A
319
32.239
−0.897
15.249
1.00
31.30
A
C


ATOM
4830
CD1
LEU
A
319
33.410
−1.842
15.024
1.00
25.53
A
C


ATOM
4834
CD2
LEU
A
319
31.421
−1.339
16.464
1.00
34.06
A
C


ATOM
4838
C
LEU
A
319
33.258
1.867
13.347
1.00
23.17
A
C


ATOM
4839
O
LEU
A
319
33.195
1.361
12.226
1.00
23.56
A
O


ATOM
4841
N
ASP
A
320
32.877
3.118
13.610
1.00
23.84
A
N


ATOM
4842
CA
ASP
A
320
32.388
4.035
12.580
1.00
26.41
A
C


ATOM
4844
CB
ASP
A
320
31.999
5.411
13.174
1.00
28.62
A
C


ATOM
4847
CG
ASP
A
320
30.753
5.370
14.089
1.00
34.92
A
C


ATOM
4848
OD1
ASP
A
320
29.889
4.480
13.934
1.00
40.85
A
O


ATOM
4849
OD2
ASP
A
320
30.633
6.273
14.960
1.00
45.71
A
O


ATOM
4850
C
ASP
A
320
33.454
4.260
11.490
1.00
25.67
A
C


ATOM
4851
O
ASP
A
320
33.133
4.313
10.319
1.00
26.46
A
O


ATOM
4853
N
GLU
A
321
34.713
4.420
11.879
1.00
24.15
A
N


ATOM
4854
CA
GLU
A
321
35.787
4.613
10.895
1.00
22.51
A
C


ATOM
4856
CB
GLU
A
321
37.102
4.984
11.579
1.00
21.98
A
C


ATOM
4859
CG
GLU
A
321
37.114
6.354
12.250
1.00
22.24
A
C


ATOM
4862
CD
GLU
A
321
38.425
6.622
13.009
1.00
26.20
A
C


ATOM
4863
OE1
GLU
A
321
39.060
5.664
13.490
1.00
22.42
A
O


ATOM
4864
OE2
GLU
A
321
38.823
7.795
13.126
1.00
26.34
A
O


ATOM
4865
C
GLU
A
321
35.997
3.346
10.075
1.00
22.83
A
C


ATOM
4866
O
GLU
A
321
36.239
3.410
8.869
1.00
20.72
A
O


ATOM
4868
N
LEU
A
322
35.902
2.191
10.735
1.00
21.58
A
N


ATOM
4869
CA
LEU
A
322
36.126
0.944
10.053
1.00
21.00
A
C


ATOM
4871
CB
LEU
A
322
36.303
−0.196
11.051
1.00
20.31
A
C


ATOM
4874
CG
LEU
A
322
37.454
−0.038
12.044
1.00
21.17
A
C


ATOM
4876
CD1
LEU
A
322
37.523
−1.242
12.977
1.00
21.39
A
C


ATOM
4880
CD2
LEU
A
322
38.778
0.167
11.355
1.00
21.53
A
C


ATOM
4884
C
LEU
A
322
34.998
0.636
9.065
1.00
22.33
A
C


ATOM
4885
O
LEU
A
322
35.233
−0.029
8.055
1.00
23.58
A
O


ATOM
4887
N
GLU
A
323
33.784
1.099
9.351
1.00
23.50
A
N


ATOM
4888
CA
GLU
A
323
32.687
0.991
8.396
1.00
23.70
A
C


ATOM
4890
CB
GLU
A
323
31.342
1.418
9.002
1.00
25.90
A
C


ATOM
4893
CG
GLU
A
323
30.728
0.464
10.031
1.00
31.83
A
C


ATOM
4896
CD
GLU
A
323
29.981
−0.734
9.421
1.00
38.05
A
C


ATOM
4897
OE1
GLU
A
323
29.503
−1.575
10.218
1.00
40.48
A
O


ATOM
4898
OE2
GLU
A
323
29.875
−0.839
8.170
1.00
39.62
A
O


ATOM
4899
C
GLU
A
323
32.991
1.873
7.193
1.00
23.25
A
C


ATOM
4900
O
GLU
A
323
32.756
1.466
6.043
1.00
20.74
A
O


ATOM
4902
N
LEU
A
324
33.507
3.082
7.434
1.00
22.29
A
N


ATOM
4903
CA
LEU
A
324
33.832
3.961
6.302
1.00
23.80
A
C


ATOM
4905
CB
LEU
A
324
34.286
5.340
6.768
1.00
25.06
A
C


ATOM
4908
CG
LEU
A
324
33.225
6.246
7.386
1.00
30.71
A
C


ATOM
4910
CD1
LEU
A
324
33.874
7.501
8.031
1.00
27.53
A
C


ATOM
4914
CD2
LEU
A
324
32.178
6.642
6.330
1.00
32.67
A
C


ATOM
4918
C
LEU
A
324
34.888
3.306
5.399
1.00
22.01
A
C


ATOM
4919
O
LEU
A
324
34.739
3.259
4.180
1.00
23.37
A
O


ATOM
4921
N
PHE
A
325
35.916
2.736
6.003
1.00
21.76
A
N


ATOM
4922
CA
PHE
A
325
36.998
2.111
5.239
1.00
21.09
A
C


ATOM
4924
CB
PHE
A
325
38.125
1.683
6.176
1.00
20.33
A
C


ATOM
4927
CG
PHE
A
325
39.389
1.362
5.465
1.00
18.41
A
C


ATOM
4928
CD1
PHE
A
325
40.259
2.364
5.107
1.00
19.45
A
C


ATOM
4930
CE1
PHE
A
325
41.431
2.078
4.437
1.00
17.94
A
C


ATOM
4932
CZ
PHE
A
325
41.746
0.809
4.112
1.00
18.28
A
C


ATOM
4934
CE2
PHE
A
325
40.879
−0.223
4.450
1.00
27.60
A
C


ATOM
4936
CD2
PHE
A
325
39.702
0.070
5.143
1.00
19.26
A
C


ATOM
4938
C
PHE
A
325
36.516
0.919
4.430
1.00
19.97
A
C


ATOM
4939
O
PHE
A
325
36.797
0.802
3.238
1.00
19.86
A
O


ATOM
4941
N
THR
A
326
35.785
0.036
5.094
1.00
21.26
A
N


ATOM
4942
CA
THR
A
326
35.189
−1.144
4.453
1.00
20.87
A
C


ATOM
4944
CB
THR
A
326
34.294
−1.897
5.435
1.00
21.86
A
C


ATOM
4946
OG1
THR
A
326
35.065
−2.222
6.594
1.00
24.18
A
O


ATOM
4948
CG2
THR
A
326
33.754
−3.180
4.828
1.00
15.64
A
C


ATOM
4952
C
THR
A
326
34.364
−0.770
3.234
1.00
21.47
A
C


ATOM
4953
O
THR
A
326
34.581
−1.306
2.146
1.00
20.27
A
O


ATOM
4955
N
ASP
A
327
33.454
0.183
3.422
1.00
23.46
A
N


ATOM
4956
CA
ASP
A
327
32.624
0.717
2.342
1.00
24.01
A
C


ATOM
4958
CB
ASP
A
327
31.644
1.747
2.914
1.00
24.35
A
C


ATOM
4961
CG
ASP
A
327
30.821
2.461
1.837
1.00
33.07
A
C


ATOM
4962
OD1
ASP
A
327
29.907
1.827
1.249
1.00
35.22
A
O


ATOM
4963
OD2
ASP
A
327
31.080
3.674
1.594
1.00
39.61
A
O


ATOM
4964
C
ASP
A
327
33.486
1.322
1.210
1.00
24.37
A
C


ATOM
4965
O
ASP
A
327
33.203
1.124
0.026
1.00
24.49
A
O


ATOM
4967
N
ALA
A
328
34.547
2.038
1.568
1.00
23.77
A
N


ATOM
4968
CA
ALA
A
328
35.410
2.652
0.559
1.00
21.98
A
C


ATOM
4970
CB
ALA
A
328
36.444
3.553
1.211
1.00
20.52
A
C


ATOM
4974
C
ALA
A
328
36.101
1.571
−0.290
1.00
20.95
A
C


ATOM
4975
O
ALA
A
328
36.252
1.727
−1.498
1.00
19.89
A
O


ATOM
4977
N
VAL
A
329
36.504
0.475
0.341
1.00
19.74
A
N


ATOM
4978
CA
VAL
A
329
37.136
−0.623
−0.385
1.00
18.98
A
C


ATOM
4980
CB
VAL
A
329
37.802
−1.638
0.563
1.00
18.57
A
C


ATOM
4982
CG1
VAL
A
329
38.961
−0.957
1.330
1.00
15.41
A
C


ATOM
4986
CG2
VAL
A
329
38.301
−2.860
−0.184
1.00
19.70
A
C


ATOM
4990
C
VAL
A
329
36.100
−1.269
−1.289
1.00
21.12
A
C


ATOM
4991
O
VAL
A
329
36.383
−1.524
−2.448
1.00
23.23
A
O


ATOM
4993
N
GLU
A
330
34.882
−1.455
−0.799
1.00
22.69
A
N


ATOM
4994
CA
GLU
A
330
33.828
−2.078
−1.610
1.00
24.26
A
C


ATOM
4996
CB
GLU
A
330
32.564
−2.299
−0.789
1.00
24.45
A
C


ATOM
4999
CG
GLU
A
330
32.659
−3.424
0.254
1.00
32.15
A
C


ATOM
5002
CD
GLU
A
330
31.415
−3.522
1.181
1.00
37.11
A
C


ATOM
5003
OE1
GLU
A
330
31.335
−4.497
1.946
1.00
41.56
A
O


ATOM
5004
OE2
GLU
A
330
30.536
−2.629
1.162
1.00
37.97
A
O


ATOM
5005
C
GLU
A
330
33.484
−1.252
−2.842
1.00
24.43
A
C


ATOM
5006
O
GLU
A
330
33.372
−1.785
−3.931
1.00
23.22
A
O


ATOM
5008
N
ARG
A
331
33.305
0.048
−2.659
1.00
24.59
A
N


ATOM
5009
CA
AARG
A
331
32.926
0.933
−3.762
0.50
25.42
A
C


ATOM
5010
CA
BARG
A
331
32.924
0.934
−3.762
0.50
25.53
A
C


ATOM
5013
CB
AARG
A
331
32.331
2.240
−3.217
0.50
25.39
A
C


ATOM
5014
CB
BARG
A
331
32.311
2.238
−3.215
0.50
25.60
A
C


ATOM
5019
CG
AARG
A
331
30.912
2.068
−2.616
0.50
29.35
A
C


ATOM
5020
CG
BARG
A
331
31.013
1.984
−2.402
0.50
30.09
A
C


ATOM
5025
CD
AARG
A
331
30.467
3.348
−1.936
0.50
31.41
A
C


ATOM
5026
CD
BARG
A
331
30.354
3.255
−1.877
0.50
32.13
A
C


ATOM
5031
NE
AARG
A
331
31.254
4.455
−2.460
0.50
36.48
A
N


ATOM
5032
NE
BARG
A
331
29.105
3.539
−2.578
0.50
39.36
A
N


ATOM
5035
CZ
AARG
A
331
32.146
5.140
−1.754
0.50
36.08
A
C


ATOM
5036
CZ
BARG
A
331
27.909
3.144
−2.156
0.50
40.76
A
C


ATOM
5037
NH1
AARG
A
331
32.820
6.106
−2.332
0.50
37.83
A
N


ATOM
5038
NH1
BARG
A
331
27.798
2.459
−1.027
0.50
40.70
A
N


ATOM
5043
NH2
AARG
A
331
32.348
4.880
−0.471
0.50
33.30
A
N


ATOM
5044
NH2
BARG
A
331
26.824
3.439
−2.854
0.50
39.88
A
N


ATOM
5049
C
ARG
A
331
34.092
1.210
−4.719
1.00
24.63
A
C


ATOM
5050
O
ARG
A
331
33.886
1.403
−5.905
1.00
25.83
A
O


ATOM
5052
N
TRP
A
332
35.315
1.224
−4.198
1.00
23.38
A
N


ATOM
5053
CA
TRP
A
332
36.540
1.354
−5.008
1.00
22.12
A
C


ATOM
5055
CB
TRP
A
332
36.827
0.035
−5.797
1.00
22.05
A
C


ATOM
5058
CG
TRP
A
332
38.233
−0.101
−6.263
1.00
19.00
A
C


ATOM
5059
CD1
TRP
A
332
38.704
0.112
−7.524
1.00
20.39
A
C


ATOM
5061
NE1
TRP
A
332
40.077
−0.096
−7.562
1.00
21.23
A
N


ATOM
5063
CE2
TRP
A
332
40.509
−0.451
−6.312
1.00
14.45
A
C


ATOM
5064
CD2
TRP
A
332
39.381
−0.461
−5.462
1.00
22.97
A
C


ATOM
5065
CE3
TRP
A
332
39.558
−0.801
−4.120
1.00
19.44
A
C


ATOM
5067
CZ3
TRP
A
332
40.841
−1.098
−3.666
1.00
21.88
A
C


ATOM
5069
CH2
TRP
A
332
41.936
−1.073
−4.536
1.00
23.07
A
C


ATOM
5071
CZ2
TRP
A
332
41.787
−0.751
−5.859
1.00
27.36
A
C


ATOM
5073
C
TRP
A
332
36.468
2.569
−5.923
1.00
21.31
A
C


ATOM
5074
O
TRP
A
332
36.673
2.481
−7.133
1.00
21.30
A
O


ATOM
5076
N
ASP
A
333
36.203
3.715
−5.311
1.00
23.84
A
N


ATOM
5077
CA
ASP
A
333
35.996
4.962
−6.028
1.00
25.51
A
C


ATOM
5079
CB
ASP
A
333
34.525
5.365
−5.884
1.00
28.49
A
C


ATOM
5082
CG
ASP
A
333
34.207
6.764
−6.429
1.00
31.34
A
C


ATOM
5083
OD1
ASP
A
333
35.061
7.438
−7.055
1.00
37.88
A
O


ATOM
5084
OD2
ASP
A
333
33.054
7.180
−6.224
1.00
35.04
A
O


ATOM
5085
C
ASP
A
333
36.901
6.000
−5.408
1.00
25.74
A
C


ATOM
5086
O
ASP
A
333
36.638
6.473
−4.315
1.00
27.33
A
O


ATOM
5088
N
VAL
A
334
37.950
6.377
−6.131
1.00
25.22
A
N


ATOM
5089
CA
VAL
A
334
38.913
7.315
−5.629
1.00
24.40
A
C


ATOM
5091
CB
VAL
A
334
40.154
7.336
−6.508
1.00
23.40
A
C


ATOM
5093
CG1
VAL
A
334
41.277
8.090
−5.851
1.00
22.78
A
C


ATOM
5097
CG2
VAL
A
334
39.839
7.911
−7.873
1.00
22.06
A
C


ATOM
5101
C
VAL
A
334
38.336
8.721
−5.512
1.00
28.91
A
C


ATOM
5102
O
VAL
A
334
38.857
9.535
−4.750
1.00
29.34
A
O


ATOM
5104
N
ASN
A
335
37.261
9.015
−6.246
1.00
30.93
A
N


ATOM
5105
CA
ASN
A
335
36.668
10.356
−6.204
1.00
32.90
A
C


ATOM
5107
CB
ASN
A
335
35.767
10.617
−7.430
1.00
33.01
A
C


ATOM
5110
CG
ASN
A
335
36.539
10.559
−8.768
1.00
35.09
A
C


ATOM
5111
OD1
ASN
A
335
37.513
11.293
−8.972
1.00
31.46
A
O


ATOM
5112
ND2
ASN
A
335
36.080
9.693
−9.690
1.00
29.46
A
N


ATOM
5115
C
ASN
A
335
35.889
10.616
−4.916
1.00
35.23
A
C


ATOM
5116
O
ASN
A
335
35.438
11.744
−4.718
1.00
37.55
A
O


ATOM
5118
N
ALA
A
336
35.737
9.588
−4.062
1.00
36.18
A
N


ATOM
5119
CA
ALA
A
336
35.107
9.702
−2.717
1.00
38.28
A
C


ATOM
5121
CB
ALA
A
336
33.972
8.678
−2.600
1.00
37.37
A
O


ATOM
5125
C
ALA
A
336
36.067
9.540
−1.501
1.00
38.39
A
C


ATOM
5126
O
ALA
A
336
35.632
9.516
−0.357
1.00
40.53
A
O


ATOM
5128
N
ILE
A
337
37.357
9.392
−1.766
1.00
39.34
A
N


ATOM
5129
CA
ILE
A
337
38.442
9.438
−0.767
1.00
39.49
A
C


ATOM
5131
CB
ILE
A
337
39.770
9.736
−1.552
1.00
41.71
A
C


ATOM
5133
CG1
ILE
A
337
41.026
9.661
−0.714
1.00
45.87
A
C


ATOM
5136
CD1
ILE
A
337
42.218
10.171
−1.518
1.00
45.13
A
C


ATOM
5140
CG2
ILE
A
337
39.745
11.124
−2.199
1.00
40.01
A
C


ATOM
5144
C
ILE
A
337
38.231
10.470
0.388
1.00
41.00
A
C


ATOM
5145
O
ILE
A
337
38.497
10.165
1.550
1.00
41.18
A
O


ATOM
5147
N
ASN
A
338
37.726
11.667
0.070
1.00
39.57
A
N


ATOM
5148
CA
ASN
A
338
37.503
12.723
1.064
1.00
39.05
A
C


ATOM
5150
CB
ASN
A
338
37.154
14.057
0.369
1.00
38.88
A
C


ATOM
5153
CG
ASN
A
338
38.379
14.735
−0.240
1.00
38.68
A
C


ATOM
5154
OD1
ASN
A
338
39.518
14.355
0.056
1.00
37.66
A
O


ATOM
5155
ND2
ASN
A
338
38.154
15.740
−1.091
1.00
32.26
A
N


ATOM
5158
C
ASN
A
338
36.484
12.420
2.180
1.00
38.52
A
C


ATOM
5159
O
ASN
A
338
36.443
13.142
3.179
1.00
36.24
A
O


ATOM
5161
N
ASP
A
339
35.695
11.360
2.017
1.00
37.68
A
N


ATOM
5162
CA
ASP
A
339
34.804
10.866
3.080
1.00
38.81
A
C


ATOM
5164
CB
ASP
A
339
33.943
9.699
2.546
1.00
41.47
A
C


ATOM
5167
CG
ASP
A
339
32.967
10.110
1.435
1.00
45.43
A
C


ATOM
5168
OD1
ASP
A
339
32.684
11.323
1.284
1.00
49.71
A
O


ATOM
5169
OD2
ASP
A
339
32.466
9.191
0.738
1.00
42.53
A
O


ATOM
5170
C
ASP
A
339
35.566
10.336
4.319
1.00
36.47
A
C


ATOM
5171
O
ASP
A
339
35.045
10.344
5.440
1.00
37.33
A
O


ATOM
5173
N
LEU
A
340
36.777
9.835
4.088
1.00
31.99
A
N


ATOM
5174
CA
LEU
A
340
37.551
9.126
5.099
1.00
28.85
A
C


ATOM
5176
CB
LEU
A
340
38.562
8.206
4.419
1.00
26.83
A
C


ATOM
5179
CG
LEU
A
340
38.040
7.105
3.512
1.00
26.05
A
C


ATOM
5181
CD1
LEU
A
340
39.177
6.481
2.697
1.00
19.73
A
C


ATOM
5185
CD2
LEU
A
340
37.335
6.075
4.347
1.00
28.12
A
C


ATOM
5189
C
LEU
A
340
38.342
10.102
5.973
1.00
27.33
A
C


ATOM
5190
O
LEU
A
340
38.664
11.198
5.525
1.00
28.68
A
O


ATOM
5192
N
PRO
A
341
38.698
9.681
7.199
1.00
24.34
A
N


ATOM
5193
CA
PRO
A
341
39.596
10.458
8.061
1.00
24.84
A
C


ATOM
5195
CB
PRO
A
341
39.422
9.801
9.439
1.00
26.28
A
C


ATOM
5198
CG
PRO
A
341
38.974
8.411
9.152
1.00
25.66
A
C


ATOM
5201
CD
PRO
A
341
38.256
8.427
7.838
1.00
23.02
A
C


ATOM
5204
C
PRO
A
341
41.037
10.361
7.585
1.00
23.92
A
C


ATOM
5205
O
PRO
A
341
41.409
9.379
6.966
1.00
23.65
A
O


ATOM
5206
N
ASP
A
342
41.835
11.381
7.878
1.00
24.01
A
N


ATOM
5207
CA
ASP
A
342
43.159
11.568
7.257
1.00
24.20
A
C


ATOM
5209
CB
ASP
A
342
43.956
12.647
8.021
1.00
24.30
A
C


ATOM
5212
CG
ASP
A
342
43.410
14.066
7.807
1.00
32.75
A
C


ATOM
5213
OD1
ASP
A
342
42.564
14.253
6.896
1.00
33.36
A
O


ATOM
5214
OD2
ASP
A
342
43.842
14.998
8.548
1.00
38.90
A
O


ATOM
5215
C
ASP
A
342
44.009
10.276
7.125
1.00
23.76
A
C


ATOM
5216
O
ASP
A
342
44.523
9.958
6.030
1.00
23.73
A
O


ATOM
5218
N
TYR
A
343
44.148
9.524
8.216
1.00
21.13
A
N


ATOM
5219
CA
TYR
A
343
45.020
8.355
8.192
1.00
20.93
A
C


ATOM
5221
CB
TYR
A
343
45.222
7.786
9.584
1.00
20.26
A
C


ATOM
5224
CG
TYR
A
343
44.066
7.002
10.157
1.00
23.08
A
C


ATOM
5225
CD1
TYR
A
343
43.048
7.626
10.855
1.00
18.13
A
C


ATOM
5227
CE1
TYR
A
343
42.009
6.903
11.384
1.00
27.05
A
C


ATOM
5229
CZ
TYR
A
343
41.994
5.521
11.239
1.00
24.51
A
C


ATOM
5230
OH
TYR
A
343
40.978
4.744
11.763
1.00
27.02
A
O


ATOM
5232
CE2
TYR
A
343
43.012
4.892
10.571
1.00
23.11
A
C


ATOM
5234
CD2
TYR
A
343
44.034
5.625
10.048
1.00
21.57
A
C


ATOM
5236
C
TYR
A
343
44.515
7.299
7.210
1.00
21.42
A
C


ATOM
5237
O
TYR
A
343
45.303
6.590
6.572
1.00
20.42
A
O


ATOM
5239
N
MET
A
344
43.204
7.235
7.053
1.00
20.78
A
N


ATOM
5240
CA
MET
A
344
42.599
6.275
6.146
1.00
22.17
A
C


ATOM
5242
CB
MET
A
344
41.151
5.989
6.556
1.00
21.39
A
C


ATOM
5245
CG
MET
A
344
41.055
5.081
7.781
1.00
19.99
A
C


ATOM
5248
SD
MET
A
344
39.358
4.723
8.256
1.00
25.10
A
S


ATOM
5249
CE
MET
A
344
39.531
3.255
9.301
1.00
20.13
A
C


ATOM
5253
C
MET
A
344
42.676
6.742
4.696
1.00
22.77
A
C


ATOM
5254
O
MET
A
344
42.854
5.928
3.799
1.00
23.66
A
O


ATOM
5256
N
LYS
A
345
42.553
8.045
4.454
1.00
24.61
A
N


ATOM
5257
CA
LYS
A
345
42.676
8.561
3.080
1.00
23.37
A
C


ATOM
5259
CB
LYS
A
345
42.640
10.084
3.016
1.00
26.29
A
C


ATOM
5262
CG
LYS
A
345
41.362
10.721
3.574
1.00
35.34
A
C


ATOM
5265
CD
LYS
A
345
41.422
12.243
3.653
1.00
37.03
A
C


ATOM
5268
CE
LYS
A
345
41.242
12.907
2.298
1.00
40.90
A
C


ATOM
5271
NZ
LYS
A
345
40.766
14.317
2.466
1.00
40.33
A
N


ATOM
5275
C
LYS
A
345
43.996
8.084
2.536
1.00
20.93
A
C


ATOM
5276
O
LYS
A
345
44.055
7.542
1.448
1.00
20.13
A
O


ATOM
5278
N
LEU
A
346
45.051
8.262
3.317
1.00
19.43
A
N


ATOM
5279
CA
LEU
A
346
46.392
7.947
2.861
1.00
19.97
A
C


ATOM
5281
CB
LEU
A
346
47.424
8.456
3.868
1.00
20.42
A
C


ATOM
5284
CG
LEU
A
346
48.885
8.424
3.430
1.00
24.60
A
C


ATOM
5286
CD1
LEU
A
346
49.118
9.356
2.220
1.00
17.76
A
C


ATOM
5290
CD2
LEU
A
346
49.789
8.796
4.594
1.00
27.43
A
C


ATOM
5294
C
LEU
A
346
46.534
6.470
2.661
1.00
21.21
A
C


ATOM
5295
O
LEU
A
346
47.029
6.024
1.655
1.00
21.29
A
O


ATOM
5297
N
CYS
A
347
46.051
5.698
3.624
1.00
23.15
A
N


ATOM
5298
CA
CYS
A
347
46.178
4.259
3.575
1.00
23.21
A
C


ATOM
5300
CB
CYS
A
347
45.760
3.653
4.943
1.00
25.14
A
C


ATOM
5303
SG
CYS
A
347
45.888
1.868
4.961
1.00
38.60
A
S


ATOM
5305
C
CYS
A
347
45.353
3.712
2.408
1.00
20.58
A
C


ATOM
5306
O
CYS
A
347
45.825
2.883
1.599
1.00
19.70
A
O


ATOM
5308
N
PHE
A
348
44.134
4.214
2.287
1.00
19.65
A
N


ATOM
5309
CA
PHE
A
348
43.299
3.863
1.155
1.00
19.61
A
C


ATOM
5311
CB
PHE
A
348
41.965
4.567
1.206
1.00
19.08
A
C


ATOM
5314
CG
PHE
A
348
41.070
4.192
0.080
1.00
18.31
A
C


ATOM
5315
CD1
PHE
A
348
40.420
2.990
0.083
1.00
22.66
A
C


ATOM
5317
CE1
PHE
A
348
39.594
2.623
−0.973
1.00
23.56
A
C


ATOM
5319
CZ
PHE
A
348
39.444
3.455
−2.043
1.00
21.10
A
C


ATOM
5321
CE2
PHE
A
348
40.096
4.662
−2.069
1.00
20.44
A
C


ATOM
5323
CD2
PHE
A
348
40.907
5.031
−1.011
1.00
24.44
A
C


ATOM
5325
C
PHE
A
348
43.951
4.141
−0.197
1.00
19.37
A
C


ATOM
5326
O
PHE
A
348
44.056
3.244
−1.037
1.00
17.63
A
O


ATOM
5328
N
LEU
A
349
44.408
5.367
−0.413
1.00
16.49
A
N


ATOM
5329
CA
LEU
A
349
44.896
5.727
−1.740
1.00
17.38
A
C


ATOM
5331
CB
LEU
A
349
45.157
7.229
−1.849
1.00
18.66
A
C


ATOM
5334
CG
LEU
A
349
45.633
7.793
−3.200
1.00
18.16
A
C


ATOM
5336
CD1
LEU
A
349
44.756
7.364
−4.359
1.00
16.21
A
C


ATOM
5340
CD2
LEU
A
349
45.700
9.321
−3.091
1.00
13.49
A
C


ATOM
5344
C
LEU
A
349
46.147
4.936
−2.076
1.00
18.98
A
C


ATOM
5345
O
LEU
A
349
46.338
4.550
−3.229
1.00
18.83
A
O


ATOM
5347
N
ALA
A
350
46.988
4.663
−1.078
1.00
19.12
A
N


ATOM
5348
CA
ALA
A
350
48.147
3.791
−1.316
1.00
20.75
A
C


ATOM
5350
CB
ALA
A
350
49.056
3.651
−0.061
1.00
19.54
A
C


ATOM
5354
C
ALA
A
350
47.716
2.426
−1.805
1.00
18.92
A
C


ATOM
5355
O
ALA
A
350
48.254
1.953
−2.787
1.00
24.29
A
O


ATOM
5357
N
LEU
A
351
46.776
1.795
−1.118
1.00
19.04
A
N


ATOM
5358
CA
LEU
A
351
46.259
0.458
−1.506
1.00
19.56
A
C


ATOM
5360
CB
LEU
A
351
45.172
−0.018
−0.503
1.00
20.96
A
C


ATOM
5363
CG
LEU
A
351
44.558
−1.412
−0.691
1.00
24.54
A
C


ATOM
5365
CD1
LEU
A
351
45.630
−2.485
−0.530
1.00
21.96
A
C


ATOM
5369
CD2
LEU
A
351
43.419
−1.645
0.287
1.00
20.98
A
C


ATOM
5373
C
LEU
A
351
45.637
0.519
−2.884
1.00
19.78
A
C


ATOM
5374
O
LEU
A
351
45.941
−0.293
−3.762
1.00
20.30
A
O


ATOM
5376
N
TYR
A
352
44.744
1.496
−3.056
1.00
19.85
A
N


ATOM
5377
CA
TYR
A
352
44.057
1.755
−4.316
1.00
17.66
A
C


ATOM
5379
CB
TYR
A
352
43.296
3.075
−4.210
1.00
20.69
A
C


ATOM
5382
CG
TYR
A
352
42.369
3.409
−5.357
1.00
16.64
A
C


ATOM
5383
CD1
TYR
A
352
41.126
2.831
−5.453
1.00
21.99
A
C


ATOM
5385
CE1
TYR
A
352
40.246
3.146
−6.517
1.00
23.38
A
C


ATOM
5387
CZ
TYR
A
352
40.618
4.062
−7.458
1.00
18.80
A
C


ATOM
5388
OH
TYR
A
352
39.759
4.352
−8.509
1.00
23.84
A
O


ATOM
5390
CE2
TYR
A
352
41.867
4.678
−7.364
1.00
18.76
A
C


ATOM
5392
CD2
TYR
A
352
42.727
4.353
−6.316
1.00
18.81
A
C


ATOM
5394
C
TYR
A
352
45.036
1.781
−5.468
1.00
17.34
A
C


ATOM
5395
O
TYR
A
352
44.892
1.025
−6.435
1.00
17.23
A
O


ATOM
5397
N
ASN
A
353
46.046
2.633
−5.374
1.00
17.53
A
N


ATOM
5398
CA
ASN
A
353
47.037
2.724
−6.448
1.00
18.17
A
C


ATOM
5400
CB
ASN
A
353
48.000
3.874
−6.213
1.00
18.33
A
C


ATOM
5403
CG
ASN
A
353
47.348
5.216
−6.429
1.00
21.12
A
C


ATOM
5404
OD1
ASN
A
353
46.297
5.299
−7.068
1.00
16.85
A
O


ATOM
5405
ND2
ASN
A
353
47.972
6.277
−5.919
1.00
12.84
A
N


ATOM
5408
C
ASN
A
353
47.819
1.441
−6.640
1.00
20.04
A
C


ATOM
5409
O
ASN
A
353
48.074
1.037
−7.770
1.00
19.38
A
O


ATOM
5411
N
THR
A
354
48.201
0.790
−5.542
1.00
19.93
A
N


ATOM
5412
CA
THR
A
354
48.989
−0.408
−5.668
1.00
19.28
A
C


ATOM
5414
CB
THR
A
354
49.441
−0.944
−4.307
1.00
21.85
A
C


ATOM
5416
OG1
THR
A
354
50.234
0.055
−3.636
1.00
18.52
A
O


ATOM
5418
CG2
THR
A
354
50.267
−2.217
−4.509
1.00
20.83
A
C


ATOM
5422
C
THR
A
354
48.210
−1.475
−6.410
1.00
19.60
A
C


ATOM
5423
O
THR
A
354
48.749
−2.127
−7.287
1.00
21.37
A
O


ATOM
5425
N
ILE
A
355
46.939
−1.651
−6.065
1.00
19.20
A
N


ATOM
5426
CA
ILE
A
355
46.126
−2.677
−6.694
1.00
18.48
A
C


ATOM
5428
CB
ILE
A
355
44.795
−2.901
−5.921
1.00
18.37
A
C


ATOM
5430
CG1
ILE
A
355
45.061
−3.350
−4.483
1.00
20.38
A
C


ATOM
5433
CD1
ILE
A
355
46.192
−4.335
−4.324
1.00
29.16
A
C


ATOM
5437
CG2
ILE
A
355
43.883
−3.902
−6.618
1.00
18.31
A
C


ATOM
5441
C
ILE
A
355
45.879
−2.313
−8.176
1.00
19.56
A
C


ATOM
5442
O
ILE
A
355
45.989
−3.176
−9.061
1.00
18.02
A
O


ATOM
5444
N
ASN
A
356
45.581
−1.042
−8.450
1.00
18.36
A
N


ATOM
5445
CA
ASN
A
356
45.340
−0.616
−9.819
1.00
18.34
A
C


ATOM
5447
CB
ASN
A
356
44.863
0.832
−9.900
1.00
17.65
A
C


ATOM
5450
CG
ASN
A
356
43.476
1.028
−9.334
1.00
16.23
A
C


ATOM
5451
OD1
ASN
A
356
42.725
0.075
−9.138
1.00
19.91
A
O


ATOM
5452
ND2
ASN
A
356
43.116
2.290
−9.083
1.00
20.98
A
N


ATOM
5455
C
ASN
A
356
46.564
−0.825
−10.703
1.00
19.43
A
C


ATOM
5456
O
ASN
A
356
46.422
−1.142
−11.887
1.00
20.70
A
O


ATOM
5458
N
GLU
A
357
47.753
−0.671
−10.132
1.00
20.68
A
N


ATOM
5459
CA
AGLU
A
357
48.994
−0.866
−10.888
0.50
21.52
A
C


ATOM
5460
CA
BGLU
A
357
49.010
−0.884
−10.874
0.50
20.35
A
C


ATOM
5463
CB
AGLU
A
357
50.194
−0.231
−10.148
0.50
22.00
A
C


ATOM
5464
CB
BGLU
A
357
50.217
−0.366
−10.079
0.50
20.11
A
C


ATOM
5469
CG
AGLU
A
357
50.380
1.275
−10.466
0.50
28.65
A
C


ATOM
5470
CG
BGLU
A
357
51.579
−0.813
−10.618
0.50
19.78
A
C


ATOM
5475
CD
AGLU
A
357
50.846
2.136
−9.291
0.50
33.37
A
C


ATOM
5476
CD
BGLU
A
357
52.743
−0.147
−9.918
0.50
23.84
A
C


ATOM
5477
OE1
AGLU
A
357
51.301
1.583
−8.270
0.50
33.65
A
O


ATOM
5478
OE1
BGLU
A
357
52.594
0.268
−8.744
0.50
29.12
A
O


ATOM
5479
OE2
AGLU
A
357
50.754
3.387
−9.402
0.50
37.95
A
O


ATOM
5480
OE2
BGLU
A
357
53.816
−0.051
−10.544
0.50
25.37
A
O


ATOM
5481
C
GLU
A
357
49.201
−2.360
−11.206
1.00
19.73
A
C


ATOM
5482
O
GLU
A
357
49.669
−2.716
−12.285
1.00
18.33
A
O


ATOM
5484
N
ILE
A
358
48.822
−3.231
−10.280
1.00
20.56
A
N


ATOM
5485
CA
ILE
A
358
48.876
−4.659
−10.536
1.00
20.75
A
C


ATOM
5487
CB
ILE
A
358
48.706
−5.508
−9.260
1.00
22.24
A
C


ATOM
5489
CG1
ILE
A
358
49.953
−5.357
−8.385
1.00
23.28
A
C


ATOM
5492
CD1
ILE
A
358
49.763
−5.808
−6.885
1.00
20.16
A
C


ATOM
5496
CG2
ILE
A
358
48.505
−7.015
−9.623
1.00
19.35
A
C


ATOM
5500
C
ILE
A
358
47.841
−5.018
−11.601
1.00
21.23
A
C


ATOM
5501
O
ILE
A
358
48.119
−5.810
−12.489
1.00
22.96
A
O


ATOM
5503
N
ALA
A
359
46.665
−4.418
−11.544
1.00
21.80
A
N


ATOM
5504
CA
ALA
A
359
45.693
−4.608
−12.625
1.00
20.99
A
C


ATOM
5506
CB
ALA
A
359
44.394
−3.864
−12.316
1.00
19.18
A
C


ATOM
5510
C
ALA
A
359
46.272
−4.131
−13.952
1.00
20.71
A
C


ATOM
5511
O
ALA
A
359
46.094
−4.789
−14.991
1.00
19.81
A
O


ATOM
5513
N
TYR
A
360
46.943
−2.972
−13.948
1.00
20.31
A
N


ATOM
5514
CA
TYR
A
360
47.532
−2.470
−15.209
1.00
18.47
A
C


ATOM
5516
CB
TYR
A
360
48.199
−1.099
−15.038
1.00
18.10
A
C


ATOM
5519
CG
TYR
A
360
48.851
−0.625
−16.318
1.00
15.44
A
C


ATOM
5520
CD1
TYR
A
360
48.097
−0.026
−17.321
1.00
12.29
A
C


ATOM
5522
CE1
TYR
A
360
48.666
0.360
−18.518
1.00
9.88
A
C


ATOM
5524
CZ
TYR
A
360
50.010
0.118
−18.751
1.00
13.42
A
C


ATOM
5525
OH
TYR
A
360
50.565
0.520
−19.932
1.00
16.96
A
O


ATOM
5527
CE2
TYR
A
360
50.790
−0.485
−17.786
1.00
8.89
A
C


ATOM
5529
CD2
TYR
A
360
50.203
−0.861
−16.568
1.00
13.09
A
C


ATOM
5531
C
TYR
A
360
48.519
−3.512
−15.761
1.00
19.61
A
C


ATOM
5532
O
TYR
A
360
48.396
−3.939
−16.901
1.00
21.66
A
O


ATOM
5534
N
ASP
A
361
49.453
−3.976
−14.931
1.00
20.81
A
N


ATOM
5535
CA
ASP
A
361
50.465
−4.969
−15.377
1.00
22.44
A
C


ATOM
5537
CB
ASP
A
361
51.307
−5.501
−14.218
1.00
23.16
A
C


ATOM
5540
CG
ASP
A
361
52.175
−4.431
−13.551
1.00
29.65
A
C


ATOM
5541
OD1
ASP
A
361
52.375
−3.309
−14.095
1.00
30.92
A
O


ATOM
5542
OD2
ASP
A
361
52.684
−4.754
−12.462
1.00
39.54
A
O


ATOM
5543
C
ASP
A
361
49.828
−6.163
−16.063
1.00
21.86
A
C


ATOM
5544
O
ASP
A
361
50.296
−6.612
−17.095
1.00
20.13
A
O


ATOM
5546
N
ASN
A
362
48.751
−6.668
−15.482
1.00
22.54
A
N


ATOM
5547
CA
ASN
A
362
48.066
−7.813
−16.036
1.00
23.29
A
C


ATOM
5549
CB
ASN
A
362
47.121
−8.407
−15.005
1.00
26.74
A
C


ATOM
5552
CG
ASN
A
362
47.831
−9.340
−14.072
1.00
27.43
A
C


ATOM
5553
OD1
ASN
A
362
47.917
−10.526
−14.337
1.00
26.92
A
O


ATOM
5554
ND2
ASN
A
362
48.403
−8.797
−13.004
1.00
30.27
A
N


ATOM
5557
C
ASN
A
362
47.324
−7.491
−17.322
1.00
24.48
A
C


ATOM
5558
O
ASN
A
362
47.420
−8.243
−18.278
1.00
23.43
A
O


ATOM
5560
N
LEU
A
363
46.628
−6.354
−17.362
1.00
23.94
A
N


ATOM
5561
CA
LEU
A
363
45.966
−5.918
−18.581
1.00
22.60
A
C


ATOM
5563
CB
LEU
A
363
45.287
−4.570
−18.389
1.00
20.18
A
C


ATOM
5566
CG
LEU
A
363
44.590
−3.967
−19.601
1.00
23.96
A
C


ATOM
5568
CD1
LEU
A
363
43.503
−4.907
−20.108
1.00
14.88
A
C


ATOM
5572
CD2
LEU
A
363
44.030
−2.552
−19.279
1.00
17.49
A
C


ATOM
5576
C
LEU
A
363
46.985
−5.838
−19.707
1.00
23.16
A
C


ATOM
5577
O
LEU
A
363
46.734
−6.307
−20.800
1.00
24.96
A
O


ATOM
5579
N
LYS
A
364
48.143
−5.263
−19.432
1.00
24.48
A
N


ATOM
5580
CA
LYS
A
364
49.149
−5.054
−20.469
1.00
23.95
A
C


ATOM
5582
CB
LYS
A
364
50.288
−4.165
−19.964
1.00
23.52
A
C


ATOM
5585
CG
LYS
A
364
51.326
−3.846
−21.033
1.00
28.36
A
C


ATOM
5588
CD
LYS
A
364
52.416
−2.904
−20.568
1.00
33.18
A
C


ATOM
5591
CE
LYS
A
364
53.575
−3.616
−19.903
1.00
29.42
A
C


ATOM
5594
NZ
LYS
A
364
53.277
−3.791
−18.504
1.00
34.02
A
N


ATOM
5598
C
LYS
A
364
49.752
−6.361
−20.967
1.00
25.61
A
C


ATOM
5599
O
LYS
A
364
50.000
−6.488
−22.163
1.00
24.47
A
O


ATOM
5601
N
ASP
A
365
50.020
−7.304
−20.053
1.00
26.63
A
N


ATOM
5602
CA
ASP
A
365
50.760
−8.530
−20.395
1.00
29.60
A
C


ATOM
5604
CB
ASP
A
365
51.663
−8.970
−19.235
1.00
28.67
A
C


ATOM
5607
CG
ASP
A
365
52.733
−7.936
−18.896
1.00
38.74
A
C


ATOM
5608
OD1
ASP
A
365
52.986
−7.008
−19.711
1.00
45.92
A
O


ATOM
5609
OD2
ASP
A
365
53.314
−8.040
−17.799
1.00
47.56
A
O


ATOM
5610
C
ASP
A
365
49.867
−9.705
−20.793
1.00
30.41
A
C


ATOM
5611
O
ASP
A
365
50.295
−10.549
−21.574
1.00
30.84
A
O


ATOM
5613
N
LYS
A
366
48.655
−9.775
−20.238
1.00
29.91
A
N


ATOM
5614
CA
LYS
A
366
47.732
−10.890
−20.515
1.00
31.66
A
C


ATOM
5616
CB
LYS
A
366
47.282
−11.573
−19.222
1.00
31.27
A
C


ATOM
5619
CG
LYS
A
366
48.393
−12.030
−18.325
1.00
37.24
A
C


ATOM
5622
CD
LYS
A
366
47.831
−12.620
−17.023
1.00
51.74
A
C


ATOM
5625
CE
LYS
A
366
48.938
−13.013
−16.050
1.00
58.01
A
C


ATOM
5628
NZ
LYS
A
366
49.938
−13.909
−16.721
1.00
65.78
A
N


ATOM
5632
C
LYS
A
366
46.493
−10.433
−21.260
1.00
31.36
A
C


ATOM
5633
O
LYS
A
366
45.638
−11.244
−21.579
1.00
34.55
A
O


ATOM
5635
N
GLY
A
367
46.372
−9.139
−21.516
1.00
29.56
A
N


ATOM
5636
CA
GLY
A
367
45.215
−8.637
−22.233
1.00
28.57
A
C


ATOM
5639
C
GLY
A
367
43.893
−8.799
−21.503
1.00
28.83
A
C


ATOM
5640
O
GLY
A
367
42.846
−8.755
−22.145
1.00
29.71
A
O


ATOM
5642
N
GLU
A
368
43.921
−8.940
−20.174
1.00
27.22
A
N


ATOM
5643
CA
GLU
A
368
42.685
−9.147
−19.396
1.00
27.74
A
C


ATOM
5645
CB
GLU
A
368
42.648
−10.563
−18.784
1.00
28.93
A
C


ATOM
5648
CG
GLU
A
368
42.646
−11.732
−19.784
1.00
38.81
A
C


ATOM
5651
CD
GLU
A
368
41.343
−11.888
−20.567
1.00
47.54
A
C


ATOM
5652
OE1
GLU
A
368
40.389
−11.104
−20.360
1.00
49.64
A
O


ATOM
5653
OE2
GLU
A
368
41.284
−12.808
−21.410
1.00
54.32
A
O


ATOM
5654
C
GLU
A
368
42.543
−8.135
−18.268
1.00
24.49
A
C


ATOM
5655
O
GLU
A
368
43.499
−7.861
−17.565
1.00
25.04
A
O


ATOM
5657
N
ASN
A
369
41.345
−7.610
−18.068
1.00
23.64
A
N


ATOM
5658
CA
ASN
A
369
41.070
−6.743
−16.922
1.00
23.23
A
C


ATOM
5660
CB
ASN
A
369
39.965
−5.744
−17.246
1.00
23.47
A
C


ATOM
5663
CG
ASN
A
369
39.625
−4.846
−16.059
1.00
26.64
A
C


ATOM
5664
OD1
ASN
A
369
40.103
−5.046
−14.935
1.00
27.47
A
O


ATOM
5665
ND2
ASN
A
369
38.801
−3.848
−16.310
1.00
21.10
A
N


ATOM
5668
C
ASN
A
369
40.646
−7.564
−15.716
1.00
22.50
A
C


ATOM
5669
O
ASN
A
369
39.515
−8.037
−15.662
1.00
23.28
A
O


ATOM
5671
N
ILE
A
370
41.548
−7.697
−14.749
1.00
20.03
A
N


ATOM
5672
CA
ILE
A
370
41.339
−8.531
−13.587
1.00
20.96
A
C


ATOM
5674
CB
ILE
A
370
42.596
−9.422
−13.301
1.00
22.00
A
C


ATOM
5676
CG1
ILE
A
370
43.822
−8.555
−12.918
1.00
22.25
A
C


ATOM
5679
CD1
ILE
A
370
44.991
−9.307
−12.305
1.00
24.22
A
C


ATOM
5683
CG2
ILE
A
370
42.925
−10.275
−14.521
1.00
22.49
A
C


ATOM
5687
C
ILE
A
370
41.038
−7.700
−12.345
1.00
22.36
A
C


ATOM
5688
O
ILE
A
370
40.934
−8.245
−11.246
1.00
23.94
A
O


ATOM
5690
N
LEU
A
371
40.927
−6.388
−12.500
1.00
21.80
A
N


ATOM
5691
CA
LEU
A
371
40.640
−5.508
−11.350
1.00
22.30
A
C


ATOM
5693
CB
LEU
A
371
40.420
−4.071
−11.808
1.00
20.64
A
C


ATOM
5696
CG
LEU
A
371
40.364
−3.036
−10.684
1.00
22.73
A
C


ATOM
5698
CD1
LEU
A
371
41.588
−3.133
−9.844
1.00
17.10
A
C


ATOM
5702
CD2
LEU
A
371
40.230
−1.641
−11.247
1.00
17.41
A
C


ATOM
5706
C
LEU
A
371
39.477
−5.941
−10.442
1.00
22.81
A
C


ATOM
5707
O
LEU
A
371
39.636
−5.947
−9.221
1.00
25.48
A
O


ATOM
5709
N
PRO
A
372
38.323
−6.322
−11.018
1.00
24.23
A
N


ATOM
5710
CA
PRO
A
372
37.194
−6.750
−10.172
1.00
24.59
A
C


ATOM
5712
CB
PRO
A
372
36.136
−7.207
−11.186
1.00
25.42
A
C


ATOM
5715
CG
PRO
A
372
36.502
−6.557
−12.470
1.00
27.16
A
C


ATOM
5718
CD
PRO
A
372
37.991
−6.388
−12.457
1.00
26.65
A
C


ATOM
5721
C
PRO
A
372
37.520
−7.921
−9.235
1.00
24.27
A
C


ATOM
5722
O
PRO
A
372
36.936
−8.036
−8.165
1.00
24.63
A
O


ATOM
5723
N
TYR
A
373
38.444
−8.778
−9.629
1.00
22.56
A
N


ATOM
5724
CA
TYR
A
373
38.785
−9.923
−8.804
1.00
23.41
A
C


ATOM
5726
CB
TYR
A
373
39.355
−11.030
−9.678
1.00
25.44
A
C


ATOM
5729
CG
TYR
A
373
38.520
−11.288
−10.950
1.00
28.81
A
C


ATOM
5730
CD1
TYR
A
373
37.220
−11.783
−10.877
1.00
39.04
A
C


ATOM
5732
CE1
TYR
A
373
36.452
−12.013
−12.040
1.00
38.13
A
C


ATOM
5734
CZ
TYR
A
373
36.999
−11.743
−13.272
1.00
39.16
A
C


ATOM
5735
OH
TYR
A
373
36.279
−11.950
−14.425
1.00
47.13
A
O


ATOM
5737
CE2
TYR
A
373
38.284
−11.243
−13.361
1.00
40.64
A
C


ATOM
5739
CD2
TYR
A
373
39.037
−11.025
−12.208
1.00
30.70
A
C


ATOM
5741
C
TYR
A
373
39.750
−9.516
−7.676
1.00
24.07
A
C


ATOM
5742
O
TYR
A
373
39.657
−10.021
−6.574
1.00
24.75
A
O


ATOM
5744
N
LEU
A
374
40.640
−8.562
−7.935
1.00
21.92
A
N


ATOM
5745
CA
LEU
A
374
41.543
−8.065
−6.904
1.00
20.05
A
C


ATOM
5747
CB
LEU
A
374
42.697
−7.268
−7.533
1.00
18.59
A
C


ATOM
5750
CG
LEU
A
374
43.440
−7.920
−8.708
1.00
21.18
A
C


ATOM
5752
CD1
LEU
A
374
44.568
−7.012
−9.281
1.00
15.63
A
C


ATOM
5756
CD2
LEU
A
374
44.002
−9.288
−8.329
1.00
21.62
A
C


ATOM
5760
C
LEU
A
374
40.748
−7.194
−5.916
1.00
19.90
A
C


ATOM
5761
O
LEU
A
374
40.908
−7.312
−4.711
1.00
21.65
A
O


ATOM
5763
N
THR
A
375
39.875
−6.324
−6.403
1.00
19.48
A
N


ATOM
5764
CA
THR
A
375
39.118
−5.465
−5.482
1.00
20.29
A
C


ATOM
5766
CB
THR
A
375
38.419
−4.297
−6.219
1.00
21.53
A
C


ATOM
5768
OG1
THR
A
375
37.533
−4.818
−7.222
1.00
23.71
A
O


ATOM
5770
CG2
THR
A
375
39.458
−3.379
−6.875
1.00
17.49
A
C


ATOM
5774
C
THR
A
375
38.093
−6.269
−4.665
1.00
20.82
A
C


ATOM
5775
O
THR
A
375
37.854
−5.989
−3.499
1.00
23.34
A
O


ATOM
5777
N
LYS
A
376
37.510
−7.299
−5.243
1.00
21.46
A
N


ATOM
5778
CA
LYS
A
376
36.592
−8.149
−4.476
1.00
22.11
A
C


ATOM
5780
CB
LYS
A
376
35.915
−9.162
−5.411
1.00
24.77
A
C


ATOM
5783
CG
LYS
A
376
35.075
−10.225
−4.732
1.00
30.99
A
C


ATOM
5786
CD
LYS
A
376
33.828
−9.640
−4.119
1.00
37.68
A
C


ATOM
5789
CE
LYS
A
376
32.933
−10.753
−3.552
1.00
43.15
A
C


ATOM
5792
NZ
LYS
A
376
32.101
−10.264
−2.422
1.00
47.30
A
N


ATOM
5796
C
LYS
A
376
37.324
−8.858
−3.345
1.00
20.58
A
C


ATOM
5797
O
LYS
A
376
36.805
−8.964
−2.259
1.00
22.25
A
O


ATOM
5799
N
ALA
A
377
38.522
−9.369
−3.612
1.00
20.81
A
N


ATOM
5800
CA
ALA
A
377
39.307
−10.072
−2.597
1.00
19.65
A
C


ATOM
5802
CB
ALA
A
377
40.581
−10.615
−3.187
1.00
20.54
A
C


ATOM
5806
C
ALA
A
377
39.635
−9.157
−1.438
1.00
22.21
A
C


ATOM
5807
O
ALA
A
377
39.599
−9.577
−0.265
1.00
24.06
A
O


ATOM
5809
N
TRP
A
378
39.918
−7.892
−1.748
1.00
20.95
A
N


ATOM
5810
CA
TRP
A
378
40.154
−6.899
−0.686
1.00
19.91
A
C


ATOM
5812
CB
TRP
A
378
40.823
−5.645
−1.240
1.00
19.12
A
C


ATOM
5815
CG
TRP
A
378
42.266
−5.807
−1.234
1.00
18.82
A
C


ATOM
5816
CD1
TRP
A
378
43.045
−6.192
−2.261
1.00
17.16
A
C


ATOM
5818
NE1
TRP
A
378
44.343
−6.281
−1.858
1.00
20.04
A
N


ATOM
5820
CE2
TRP
A
378
44.416
−5.964
−0.528
1.00
15.91
A
C


ATOM
5821
CD2
TRP
A
378
43.115
−5.692
−0.098
1.00
19.67
A
C


ATOM
5822
CE3
TRP
A
378
42.903
−5.345
1.237
1.00
17.94
A
C


ATOM
5824
CZ3
TRP
A
378
43.989
−5.290
2.080
1.00
22.51
A
C


ATOM
5826
CH2
TRP
A
378
45.271
−5.571
1.624
1.00
15.95
A
C


ATOM
5828
CZ2
TRP
A
378
45.510
−5.902
0.324
1.00
15.79
A
C


ATOM
5830
C
TRP
A
378
38.908
−6.516
0.109
1.00
19.57
A
C


ATOM
5831
O
TRP
A
378
38.994
−6.297
1.313
1.00
19.10
A
O


ATOM
5833
N
ALA
A
379
37.779
−6.386
−0.577
1.00
17.51
A
N


ATOM
5834
CA
ALA
A
379
36.511
−6.130
0.083
1.00
18.56
A
C


ATOM
5836
CB
ALA
A
379
35.377
−5.971
−0.957
1.00
19.21
A
C


ATOM
5840
C
ALA
A
379
36.179
−7.267
1.040
1.00
20.27
A
C


ATOM
5841
O
ALA
A
379
35.706
−7.046
2.155
1.00
22.16
A
O


ATOM
5843
N
ASP
A
380
36.405
−8.495
0.601
1.00
20.50
A
N


ATOM
5844
CA
ASP
A
380
36.081
−9.638
1.448
1.00
21.17
A
C


ATOM
5846
CB
ASP
A
380
36.238
−10.964
0.695
1.00
21.00
A
C


ATOM
5849
CG
ASP
A
380
35.187
−11.187
−0.412
1.00
21.43
A
C


ATOM
5850
OD1
ASP
A
380
34.167
−10.468
−0.515
1.00
25.52
A
O


ATOM
5851
OD2
ASP
A
380
35.379
−12.153
−1.177
1.00
29.89
A
O


ATOM
5852
C
ASP
A
380
37.009
−9.625
2.662
1.00
21.11
A
C


ATOM
5853
O
ASP
A
380
36.589
−9.925
3.778
1.00
25.31
A
O


ATOM
5855
N
LEU
A
381
38.273
−9.283
2.456
1.00
21.14
A
N


ATOM
5856
CA
LEU
A
381
39.216
−9.230
3.581
1.00
20.85
A
C


ATOM
5858
CB
LEU
A
381
40.641
−8.952
3.113
1.00
19.68
A
C


ATOM
5861
CG
LEU
A
381
41.690
−8.904
4.212
1.00
22.69
A
C


ATOM
5863
CD1
LEU
A
381
41.645
−10.153
5.076
1.00
17.32
A
C


ATOM
5867
CD2
LEU
A
381
43.038
−8.730
3.552
1.00
20.69
A
C


ATOM
5871
C
LEU
A
381
38.781
−8.183
4.584
1.00
18.62
A
C


ATOM
5872
O
LEU
A
381
38.690
−8.459
5.778
1.00
20.47
A
O


ATOM
5874
N
CYS
A
382
38.457
−6.990
4.102
1.00
21.03
A
N


ATOM
5875
CA
CYS
A
382
38.090
−5.891
5.023
1.00
20.56
A
C


ATOM
5877
CB
CYS
A
382
38.032
−4.551
4.283
1.00
21.31
A
C


ATOM
5880
SG
CYS
A
382
39.664
−3.962
3.712
1.00
24.85
A
S


ATOM
5882
C
CYS
A
382
36.799
−6.217
5.764
1.00
19.73
A
C


ATOM
5883
O
CYS
A
382
36.676
−5.968
6.959
1.00
23.50
A
O


ATOM
5885
N
ASN
A
383
35.850
−6.829
5.080
1.00
21.14
A
N


ATOM
5886
CA
ASN
A
383
34.646
−7.367
5.742
1.00
21.35
A
C


ATOM
5888
CB
ASN
A
383
33.630
−7.901
4.721
1.00
21.45
A
C


ATOM
5891
CG
ASN
A
383
32.701
−6.810
4.213
1.00
26.00
A
C


ATOM
5892
OD1
ASN
A
383
31.849
−6.300
4.960
1.00
32.37
A
O


ATOM
5893
ND2
ASN
A
383
32.875
−6.426
2.948
1.00
24.66
A
N


ATOM
5896
C
ASN
A
383
34.936
−8.458
6.753
1.00
21.61
A
C


ATOM
5897
O
ASN
A
383
34.282
−8.523
7.780
1.00
22.90
A
O


ATOM
5899
N
ALA
A
384
35.900
−9.328
6.486
1.00
21.49
A
N


ATOM
5900
CA
ALA
A
384
36.234
−10.330
7.505
1.00
19.41
A
C


ATOM
5902
CB
ALA
A
384
37.163
−11.414
6.934
1.00
15.55
A
C


ATOM
5906
C
ALA
A
384
36.851
−9.602
8.744
1.00
18.65
A
C


ATOM
5907
O
ALA
A
384
36.449
−9.851
9.886
1.00
18.75
A
O


ATOM
5909
N
PHE
A
385
37.785
−8.682
8.517
1.00
18.91
A
N


ATOM
5910
CA
PHE
A
385
38.319
−7.831
9.626
1.00
20.64
A
C


ATOM
5912
CB
PHE
A
385
39.311
−6.773
9.127
1.00
21.86
A
C


ATOM
5915
CG
PHE
A
385
40.647
−7.296
8.653
1.00
18.71
A
C


ATOM
5916
CD1
PHE
A
385
41.305
−8.317
9.312
1.00
27.92
A
C


ATOM
5918
CE1
PHE
A
385
42.566
−8.754
8.889
1.00
23.74
A
C


ATOM
5920
CZ
PHE
A
385
43.190
−8.126
7.810
1.00
25.70
A
C


ATOM
5922
CE2
PHE
A
385
42.544
−7.058
7.171
1.00
24.54
A
C


ATOM
5924
CD2
PHE
A
385
41.296
−6.652
7.608
1.00
22.39
A
C


ATOM
5926
C
PHE
A
385
37.199
−7.059
10.362
1.00
21.40
A
C


ATOM
5927
O
PHE
A
385
37.158
−7.013
11.590
1.00
24.82
A
O


ATOM
5929
N
LEU
A
386
36.293
−6.439
9.621
1.00
21.38
A
N


ATOM
5930
CA
LEU
A
386
35.174
−5.721
10.254
1.00
20.88
A
C


ATOM
5932
CB
LEU
A
386
34.226
−5.138
9.186
1.00
20.67
A
C


ATOM
5935
CG
LEU
A
386
33.068
−4.256
9.667
1.00
24.05
A
C


ATOM
5937
CD1
LEU
A
386
33.624
−2.975
10.307
1.00
17.84
A
C


ATOM
5941
CD2
LEU
A
386
32.096
−3.922
8.539
1.00
14.02
A
C


ATOM
5945
C
LEU
A
386
34.390
−6.629
11.200
1.00
20.84
A
C


ATOM
5946
O
LEU
A
386
34.093
−6.263
12.350
1.00
22.03
A
O


ATOM
5948
N
GLN
A
387
34.050
−7.816
10.725
1.00
21.21
A
N


ATOM
5949
CA
GLN
A
387
33.315
−8.754
11.561
1.00
22.62
A
C


ATOM
5951
CB
GLN
A
387
33.016
−10.052
10.816
1.00
23.54
A
C


ATOM
5954
CG
GLN
A
387
32.222
−11.067
11.634
1.00
23.83
A
C


ATOM
5957
CD
GLN
A
387
30.830
−10.587
11.951
1.00
23.98
A
C


ATOM
5958
OE1
GLN
A
387
30.560
−10.108
13.050
1.00
26.91
A
O


ATOM
5959
NE2
GLN
A
387
29.933
−10.715
10.987
1.00
30.18
A
N


ATOM
5962
C
GLN
A
387
34.082
−9.045
12.847
1.00
23.68
A
C


ATOM
5963
O
GLN
A
387
33.491
−9.080
13.933
1.00
21.96
A
O


ATOM
5965
N
GLU
A
388
35.393
−9.237
12.738
1.00
24.58
A
N


ATOM
5966
CA
GLU
A
388
36.209
−9.469
13.935
1.00
24.13
A
C


ATOM
5968
CB
GLU
A
388
37.684
−9.705
13.601
1.00
23.71
A
C


ATOM
5971
CG
GLU
A
388
37.932
−11.099
13.059
1.00
31.30
A
C


ATOM
5974
CD
GLU
A
388
39.385
−11.373
12.675
1.00
36.02
A
C


ATOM
5975
OE1
GLU
A
388
40.209
−10.407
12.511
1.00
32.55
A
O


ATOM
5976
OE2
GLU
A
388
39.674
−12.582
12.531
1.00
30.48
A
O


ATOM
5977
C
GLU
A
388
36.108
−8.308
14.885
1.00
21.29
A
C


ATOM
5978
O
GLU
A
388
35.996
−8.503
16.091
1.00
19.35
A
O


ATOM
5980
N
ALA
A
389
36.164
−7.098
14.343
1.00
20.43
A
N


ATOM
5981
CA
ALA
A
389
36.155
−5.918
15.196
1.00
19.95
A
C


ATOM
5983
CB
ALA
A
389
36.443
−4.670
14.404
1.00
17.61
A
C


ATOM
5987
C
ALA
A
389
34.797
−5.816
15.883
1.00
20.79
A
C


ATOM
5988
O
ALA
A
389
34.724
−5.453
17.045
1.00
22.39
A
O


ATOM
5990
N
LYS
A
390
33.729
−6.150
15.162
1.00
21.47
A
N


ATOM
5991
CA
LYS
A
390
32.387
−6.056
15.711
1.00
22.95
A
C


ATOM
5993
CB
LYS
A
390
31.347
−6.272
14.611
1.00
22.84
A
C


ATOM
5996
CG
LYS
A
390
31.150
−5.048
13.739
1.00
25.85
A
C


ATOM
5999
CD
LYS
A
390
30.033
−5.259
12.719
1.00
33.32
A
C


ATOM
6002
CE
LYS
A
390
29.796
−4.002
11.896
1.00
31.02
A
C


ATOM
6005
NZ
LYS
A
390
28.888
−4.249
10.737
1.00
29.50
A
N


ATOM
6009
C
LYS
A
390
32.187
−7.065
16.837
1.00
24.05
A
C


ATOM
6010
O
LYS
A
390
31.632
−6.753
17.885
1.00
24.65
A
O


ATOM
6012
N
TRP
A
391
32.641
−8.283
16.616
1.00
24.13
A
N


ATOM
6013
CA
TRP
A
391
32.563
−9.303
17.650
1.00
24.58
A
C


ATOM
6015
CB
TRP
A
391
33.143
−10.619
17.154
1.00
23.28
A
C


ATOM
6018
CG
TRP
A
391
32.225
−11.389
16.264
1.00
23.35
A
C


ATOM
6019
CD1
TRP
A
391
30.864
−11.354
16.250
1.00
21.14
A
C


ATOM
6021
NE1
TRP
A
391
30.373
−12.235
15.311
1.00
24.01
A
N


ATOM
6023
CE2
TRP
A
391
31.428
−12.876
14.721
1.00
24.82
A
C


ATOM
6024
CD2
TRP
A
391
32.610
−12.365
15.298
1.00
19.00
A
C


ATOM
6025
CE3
TRP
A
391
33.838
−12.866
14.868
1.00
23.69
A
C


ATOM
6027
CZ3
TRP
A
391
33.850
−13.832
13.882
1.00
17.43
A
C


ATOM
6029
CH2
TRP
A
391
32.657
−14.317
13.325
1.00
20.76
A
C


ATOM
6031
CZ2
TRP
A
391
31.444
−13.852
13.722
1.00
22.46
A
C


ATOM
6033
C
TRP
A
391
33.288
−8.885
18.920
1.00
25.69
A
C


ATOM
6034
O
TRP
A
391
32.775
−9.100
20.029
1.00
25.53
A
O


ATOM
6036
N
LEU
A
392
34.463
−8.286
18.764
1.00
25.73
A
N


ATOM
6037
CA
LEU
A
392
35.227
−7.805
19.918
1.00
28.86
A
C


ATOM
6039
CB
LEU
A
392
36.604
−7.319
19.470
1.00
30.60
A
C


ATOM
6042
CG
LEU
A
392
37.653
−7.119
20.559
1.00
36.67
A
C


ATOM
6044
CD1
LEU
A
392
39.053
−7.245
19.946
1.00
40.63
A
C


ATOM
6048
CD2
LEU
A
392
37.478
−5.762
21.262
1.00
44.84
A
C


ATOM
6052
C
LEU
A
392
34.491
−6.698
20.687
1.00
28.06
A
C


ATOM
6053
O
LEU
A
392
34.347
−6.775
21.910
1.00
28.35
A
O


ATOM
6055
N
TYR
A
393
34.014
−5.684
19.972
1.00
26.84
A
N


ATOM
6056
CA
TYR
A
393
33.328
−4.551
20.604
1.00
27.94
A
C


ATOM
6058
CB
TYR
A
393
32.933
−3.512
19.543
1.00
29.05
A
C


ATOM
6061
CG
TYR
A
393
32.189
−2.306
20.078
1.00
33.13
A
C


ATOM
6062
CD1
TYR
A
393
32.877
−1.226
20.635
1.00
38.76
A
C


ATOM
6064
CE1
TYR
A
393
32.198
−0.112
21.146
1.00
40.86
A
C


ATOM
6066
CZ
TYR
A
393
30.817
−0.066
21.085
1.00
42.91
A
C


ATOM
6067
OH
TYR
A
393
30.143
1.030
21.583
1.00
50.26
A
O


ATOM
6069
CE2
TYR
A
393
30.107
−1.123
20.526
1.00
40.58
A
C


ATOM
6071
CD2
TYR
A
393
30.801
−2.236
20.021
1.00
39.09
A
C


ATOM
6073
C
TYR
A
393
32.079
−4.996
21.374
1.00
27.58
A
C


ATOM
6074
O
TYR
A
393
31.853
−4.573
22.506
1.00
26.98
A
O


ATOM
6076
N
ASN
A
394
31.282
−5.851
20.738
1.00
27.69
A
N


ATOM
6077
CA
ASN
A
394
30.010
−6.312
21.272
1.00
27.80
A
C


ATOM
6079
CB
ASN
A
394
29.091
−6.716
20.120
1.00
26.84
A
C


ATOM
6082
CG
ASN
A
394
28.616
−5.521
19.324
1.00
28.06
A
C


ATOM
6083
OD1
ASN
A
394
28.225
−4.498
19.890
1.00
31.10
A
O


ATOM
6084
ND2
ASN
A
394
28.644
−5.636
18.010
1.00
32.05
A
N


ATOM
6087
C
ASN
A
394
30.156
−7.458
22.261
1.00
29.31
A
C


ATOM
6088
O
ASN
A
394
29.158
−7.944
22.801
1.00
29.60
A
O


ATOM
6090
N
LYS
A
395
31.402
−7.865
22.511
1.00
30.96
A
N


ATOM
6091
CA
LYS
A
395
31.706
−9.034
23.329
1.00
32.88
A
C


ATOM
6093
CB
LYS
A
395
31.443
−8.749
24.815
1.00
34.38
A
C


ATOM
6096
CG
LYS
A
395
32.374
−7.690
25.445
1.00
42.56
A
C


ATOM
6099
CD
LYS
A
395
31.603
−6.475
25.978
1.00
50.78
A
C


ATOM
6102
CE
LYS
A
395
32.434
−5.652
26.968
1.00
54.57
A
C


ATOM
6105
NZ
LYS
A
395
31.610
−4.582
27.621
1.00
55.82
A
N


ATOM
6109
C
LYS
A
395
30.923
−10.279
22.863
1.00
32.85
A
C


ATOM
6110
O
LYS
A
395
30.490
−11.090
23.686
1.00
34.23
A
O


ATOM
6112
N
SER
A
396
30.765
−10.431
21.546
1.00
31.79
A
N


ATOM
6113
CA
SER
A
396
30.034
−11.571
20.970
1.00
30.45
A
C


ATOM
6115
CB
SER
A
396
29.868
−11.402
19.464
1.00
29.95
A
C


ATOM
6118
OG
SER
A
396
29.007
−10.318
19.148
1.00
31.64
A
O


ATOM
6120
C
SER
A
396
30.730
−12.899
21.259
1.00
29.40
A
C


ATOM
6121
O
SER
A
396
31.933
−12.948
21.512
1.00
31.77
A
O


ATOM
6123
N
THR
A
397
29.948
−13.971
21.222
1.00
28.99
A
N


ATOM
6124
CA
THR
A
397
30.423
−15.315
21.529
1.00
27.69
A
C


ATOM
6126
CB
THR
A
397
29.822
−15.821
22.880
1.00
28.85
A
C


ATOM
6128
OG1
THR
A
397
28.392
−15.908
22.774
1.00
29.53
A
O


ATOM
6130
CG2
THR
A
397
30.183
−14.877
24.028
1.00
27.66
A
C


ATOM
6134
C
THR
A
397
30.017
−16.273
20.407
1.00
26.90
A
C


ATOM
6135
O
THR
A
397
29.316
−17.266
20.658
1.00
29.05
A
O


ATOM
6137
N
PRO
A
398
30.466
−16.003
19.168
1.00
23.74
A
N


ATOM
6138
CA
PRO
A
398
30.051
−16.849
18.046
1.00
23.94
A
C


ATOM
6140
CB
PRO
A
398
30.741
−16.196
16.855
1.00
23.33
A
C


ATOM
6143
CG
PRO
A
398
32.020
−15.684
17.456
1.00
24.23
A
C


ATOM
6146
CD
PRO
A
398
31.632
−15.176
18.816
1.00
23.86
A
C


ATOM
6149
C
PRO
A
398
30.558
−18.274
18.192
1.00
22.60
A
C


ATOM
6150
O
PRO
A
398
31.522
−18.516
18.905
1.00
23.64
A
O


ATOM
6151
N
THR
A
399
29.918
−19.210
17.511
1.00
22.40
A
N


ATOM
6152
CA
THR
A
399
30.354
−20.602
17.542
1.00
21.81
A
C


ATOM
6154
CB
THR
A
399
29.367
−21.499
16.770
1.00
23.98
A
C


ATOM
6156
OG1
THR
A
399
29.377
−21.129
15.376
1.00
24.75
A
O


ATOM
6158
CG2
THR
A
399
27.909
−21.381
17.366
1.00
14.91
A
C


ATOM
6162
C
THR
A
399
31.716
−20.718
16.882
1.00
22.61
A
C


ATOM
6163
O
THR
A
399
32.127
−19.807
16.181
1.00
26.36
A
O


ATOM
6165
N
PHE
A
400
32.411
−21.839
17.094
1.00
23.40
A
N


ATOM
6166
CA
PHE
A
400
33.704
−22.095
16.443
1.00
22.11
A
C


ATOM
6168
CB
PHE
A
400
34.252
−23.474
16.814
1.00
22.13
A
C


ATOM
6171
CG
PHE
A
400
35.471
−23.874
16.008
1.00
24.27
A
C


ATOM
6172
CD1
PHE
A
400
36.709
−23.344
16.297
1.00
25.15
A
C


ATOM
6174
CE1
PHE
A
400
37.825
−23.700
15.562
1.00
27.59
A
C


ATOM
6176
CZ
PHE
A
400
37.706
−24.594
14.508
1.00
24.77
A
C


ATOM
6178
CE2
PHE
A
400
36.485
−25.112
14.212
1.00
26.28
A
C


ATOM
6180
CD2
PHE
A
400
35.370
−24.765
14.961
1.00
27.15
A
C


ATOM
6182
C
PHE
A
400
33.607
−22.031
14.942
1.00
22.50
A
C


ATOM
6183
O
PHE
A
400
34.444
−21.431
14.291
1.00
24.88
A
O


ATOM
6185
N
ASP
A
401
32.592
−22.671
14.386
1.00
23.39
A
N


ATOM
6186
CA
ASP
A
401
32.403
−22.692
12.937
1.00
24.28
A
C


ATOM
6188
CB
ASP
A
401
31.188
−23.522
12.564
1.00
23.91
A
C


ATOM
6191
CG
ASP
A
401
31.358
−24.979
12.941
1.00
28.76
A
C


ATOM
6192
OD1
ASP
A
401
32.437
−25.532
12.673
1.00
27.85
A
O


ATOM
6193
OD2
ASP
A
401
30.423
−25.559
13.533
1.00
36.29
A
O


ATOM
6194
C
ASP
A
401
32.284
−21.294
12.338
1.00
25.29
A
C


ATOM
6195
O
ASP
A
401
32.891
−21.033
11.298
1.00
24.72
A
O


ATOM
6197
N
ASP
A
402
31.512
−20.417
12.991
1.00
25.45
A
N


ATOM
6198
CA
ASP
A
402
31.359
−19.016
12.557
1.00
25.75
A
C


ATOM
6200
CB
ASP
A
402
30.248
−18.298
13.337
1.00
24.45
A
C


ATOM
6203
CG
ASP
A
402
28.864
−18.808
13.005
1.00
31.45
A
C


ATOM
6204
OD1
ASP
A
402
28.671
−19.403
11.913
1.00
37.61
A
O


ATOM
6205
OD2
ASP
A
402
27.959
−18.589
13.847
1.00
37.38
A
O


ATOM
6206
C
ASP
A
402
32.664
−18.196
12.708
1.00
25.83
A
C


ATOM
6207
O
ASP
A
402
33.042
−17.481
11.782
1.00
26.75
A
O


ATOM
6209
N
TYR
A
403
33.329
−18.301
13.861
1.00
23.13
A
N


ATOM
6210
CA
TYR
A
403
34.579
−17.565
14.082
1.00
24.59
A
C


ATOM
6212
CB
TYR
A
403
35.098
−17.728
15.511
1.00
24.61
A
C


ATOM
6215
CG
TYR
A
403
36.334
−16.894
15.730
1.00
28.40
A
C


ATOM
6216
CD1
TYR
A
403
36.236
−15.532
15.998
1.00
32.59
A
C


ATOM
6218
CE1
TYR
A
403
37.367
−14.758
16.178
1.00
34.56
A
C


ATOM
6220
CZ
TYR
A
403
38.607
−15.340
16.074
1.00
33.11
A
C


ATOM
6221
OH
TYR
A
403
39.730
−14.586
16.261
1.00
39.07
A
O


ATOM
6223
CE2
TYR
A
403
38.730
−16.683
15.799
1.00
36.49
A
C


ATOM
6225
CD2
TYR
A
403
37.598
−17.450
15.621
1.00
29.76
A
C


ATOM
6227
C
TYR
A
403
35.694
−17.999
13.161
1.00
24.10
A
C


ATOM
6228
O
TYR
A
403
36.406
−17.162
12.585
1.00
24.93
A
O


ATOM
6230
N
PHE
A
404
35.873
−19.315
13.073
1.00
23.56
A
N


ATOM
6231
CA
PHE
A
404
36.904
−19.899
12.235
1.00
22.27
A
C


ATOM
6233
CB
PHE
A
404
37.024
−21.394
12.494
1.00
21.27
A
C


ATOM
6236
CG
PHE
A
404
38.023
−22.073
11.628
1.00
21.41
A
C


ATOM
6237
CD1
PHE
A
404
39.364
−21.747
11.713
1.00
23.52
A
C


ATOM
6239
CE1
PHE
A
404
40.280
−22.365
10.908
1.00
20.75
A
C


ATOM
6241
CZ
PHE
A
404
39.877
−23.310
10.012
1.00
19.51
A
C


ATOM
6243
CE2
PHE
A
404
38.550
−23.641
9.903
1.00
24.73
A
C


ATOM
6245
CD2
PHE
A
404
37.627
−23.022
10.701
1.00
25.71
A
C


ATOM
6247
C
PHE
A
404
36.611
−19.655
10.769
1.00
23.34
A
C


ATOM
6248
O
PHE
A
404
37.539
−19.400
9.990
1.00
24.39
A
O


ATOM
6250
N
GLY
A
405
35.338
−19.738
10.387
1.00
23.21
A
N


ATOM
6251
CA
GLY
A
405
34.937
−19.437
9.004
1.00
24.54
A
C


ATOM
6254
C
GLY
A
405
35.401
−18.050
8.580
1.00
24.99
A
C


ATOM
6255
O
GLY
A
405
35.994
−17.879
7.533
1.00
28.71
A
O


ATOM
6257
N
ASN
A
406
35.145
−17.062
9.423
1.00
24.64
A
N


ATOM
6258
CA
ASN
A
406
35.613
−15.697
9.202
1.00
23.03
A
C


ATOM
6260
CB
ASN
A
406
34.943
−14.761
10.193
1.00
22.91
A
C


ATOM
6263
CG
ASN
A
406
35.200
−13.294
9.881
1.00
22.65
A
C


ATOM
6264
OD1
ASN
A
406
34.666
−12.755
8.927
1.00
21.35
A
O


ATOM
6265
ND2
ASN
A
406
35.999
−12.646
10.709
1.00
10.69
A
N


ATOM
6268
C
ASN
A
406
37.137
−15.589
9.322
1.00
22.38
A
C


ATOM
6269
O
ASN
A
406
37.770
−14.927
8.512
1.00
22.73
A
O


ATOM
6271
N
ALA
A
407
37.717
−16.273
10.311
1.00
21.38
A
N


ATOM
6272
CA
ALA
A
407
39.138
−16.136
10.630
1.00
19.47
A
C


ATOM
6274
CB
ALA
A
407
39.437
−16.829
11.920
1.00
18.28
A
C


ATOM
6278
C
ALA
A
407
40.118
−16.626
9.546
1.00
21.80
A
C


ATOM
6279
O
ALA
A
407
41.210
−16.042
9.394
1.00
20.64
A
O


ATOM
6281
N
TRP
A
408
39.767
−17.691
8.817
1.00
20.25
A
N


ATOM
6282
CA
TRP
A
408
40.648
−18.153
7.738
1.00
21.62
A
C


ATOM
6284
CB
TRP
A
408
40.410
−19.619
7.303
1.00
20.05
A
C


ATOM
6287
CG
TRP
A
408
39.101
−20.016
6.707
1.00
20.37
A
C


ATOM
6288
CD1
TRP
A
408
38.120
−20.717
7.331
1.00
22.39
A
C


ATOM
6290
NE1
TRP
A
408
37.081
−20.959
6.468
1.00
22.00
A
N


ATOM
6292
CE2
TRP
A
408
37.389
−20.445
5.242
1.00
25.44
A
C


ATOM
6293
CD2
TRP
A
408
38.661
−19.852
5.342
1.00
24.30
A
C


ATOM
6294
CE3
TRP
A
408
39.204
−19.239
4.215
1.00
21.11
A
C


ATOM
6296
CZ3
TRP
A
408
38.484
−19.231
3.054
1.00
23.35
A
C


ATOM
6298
CH2
TRP
A
408
37.218
−19.843
2.972
1.00
25.47
A
C


ATOM
6300
CZ2
TRP
A
408
36.656
−20.454
4.058
1.00
28.32
A
C


ATOM
6302
C
TRP
A
408
40.645
−17.193
6.560
1.00
21.64
A
C


ATOM
6303
O
TRP
A
408
41.626
−17.105
5.835
1.00
25.03
A
O


ATOM
6305
N
LYS
A
409
39.555
−16.457
6.393
1.00
21.99
A
N


ATOM
6306
CA
LYS
A
409
39.512
−15.343
5.452
1.00
20.54
A
C


ATOM
6308
CB
LYS
A
409
38.064
−14.918
5.204
1.00
21.65
A
C


ATOM
6311
CG
LYS
A
409
37.258
−15.966
4.401
1.00
26.50
A
C


ATOM
6314
CD
LYS
A
409
35.889
−15.427
3.920
1.00
37.40
A
C


ATOM
6317
CE
LYS
A
409
34.998
−16.525
3.284
1.00
37.80
A
C


ATOM
6320
NZ
LYS
A
409
34.458
−17.478
4.334
1.00
45.51
A
N


ATOM
6324
C
LYS
A
409
40.336
−14.142
5.947
1.00
20.29
A
C


ATOM
6325
O
LYS
A
409
41.041
−13.522
5.166
1.00
19.77
A
O


ATOM
6327
N
SER
A
410
40.238
−13.822
7.240
1.00
20.14
A
N


ATOM
6328
CA
SER
A
410
40.942
−12.689
7.809
1.00
20.34
A
C


ATOM
6330
CB
SER
A
410
40.355
−12.306
9.171
1.00
21.88
A
C


ATOM
6333
OG
SER
A
410
40.776
−13.162
10.222
1.00
22.69
A
O


ATOM
6335
C
SER
A
410
42.444
−12.915
7.940
1.00
21.36
A
C


ATOM
6336
O
SER
A
410
43.181
−11.974
8.121
1.00
25.27
A
O


ATOM
6338
N
SER
A
411
42.894
−14.159
7.853
1.00
21.66
A
N


ATOM
6339
CA
SER
A
411
44.323
−14.472
7.749
1.00
19.61
A
C


ATOM
6341
CB
SER
A
411
44.498
−15.982
7.515
1.00
20.08
A
C


ATOM
6344
OG
SER
A
411
44.053
−16.360
6.210
1.00
16.88
A
O


ATOM
6346
C
SER
A
411
44.978
−13.744
6.578
1.00
19.91
A
C


ATOM
6347
O
SER
A
411
46.162
−13.450
6.635
1.00
21.95
A
O


ATOM
6349
N
SER
A
412
44.191
−13.545
5.514
1.00
21.23
A
N


ATOM
6350
CA
SER
A
412
44.583
−13.016
4.210
1.00
22.76
A
C


ATOM
6352
CB
SER
A
412
45.556
−11.838
4.292
1.00
23.35
A
C


ATOM
6355
OG
SER
A
412
46.887
−12.243
4.513
1.00
23.24
A
O


ATOM
6357
C
SER
A
412
45.145
−14.076
3.279
1.00
24.50
A
C


ATOM
6358
O
SER
A
412
45.498
−13.765
2.140
1.00
25.91
A
O


ATOM
6360
N
GLY
A
413
45.193
−15.324
3.726
1.00
21.84
A
N


ATOM
6361
CA
GLY
A
413
45.631
−16.399
2.840
1.00
21.18
A
C


ATOM
6364
C
GLY
A
413
44.883
−16.434
1.512
1.00
21.67
A
C


ATOM
6365
O
GLY
A
413
45.486
−16.563
0.421
1.00
23.81
A
O


ATOM
6367
N
PRO
A
414
43.563
−16.338
1.573
1.00
19.53
A
N


ATOM
6368
CA
PRO
A
414
42.874
−16.401
0.317
1.00
20.30
A
C


ATOM
6370
CB
PRO
A
414
41.403
−16.323
0.743
1.00
21.26
A
C


ATOM
6373
CG
PRO
A
414
41.405
−16.957
2.086
1.00
19.47
A
C


ATOM
6376
CD
PRO
A
414
42.621
−16.372
2.708
1.00
18.13
A
C


ATOM
6379
C
PRO
A
414
43.244
−15.251
−0.621
1.00
20.27
A
C


ATOM
6380
O
PRO
A
414
43.472
−15.460
−1.813
1.00
21.85
A
O


ATOM
6381
N
LEU
A
415
43.319
−14.047
−0.088
1.00
22.69
A
N


ATOM
6382
CA
LEU
A
415
43.651
−12.894
−0.914
1.00
21.21
A
C


ATOM
6384
CB
LEU
A
415
43.542
−11.617
−0.091
1.00
23.62
A
C


ATOM
6387
CG
LEU
A
415
44.014
−10.325
−0.761
1.00
25.57
A
C


ATOM
6389
CD1
LEU
A
415
43.140
−9.131
−0.331
1.00
24.96
A
C


ATOM
6393
CD2
LEU
A
415
45.473
−10.080
−0.413
1.00
23.56
A
C


ATOM
6397
C
LEU
A
415
45.037
−13.046
−1.495
1.00
20.90
A
C


ATOM
6398
O
LEU
A
415
45.251
−12.774
−2.673
1.00
20.89
A
O


ATOM
6400
N
GLN
A
416
45.991
−13.480
−0.682
1.00
20.64
A
N


ATOM
6401
CA
GLN
A
416
47.343
−13.694
−1.193
1.00
21.69
A
C


ATOM
6403
CB
GLN
A
416
48.251
−14.217
−0.111
1.00
22.06
A
C


ATOM
6406
CG
GLN
A
416
48.534
−13.218
0.973
1.00
22.59
A
C


ATOM
6409
CD
GLN
A
416
49.502
−13.765
1.993
1.00
26.11
A
C


ATOM
6410
OE1
GLN
A
416
50.390
−14.547
1.671
1.00
29.66
A
O


ATOM
6411
NE2
GLN
A
416
49.336
−13.354
3.230
1.00
25.39
A
N


ATOM
6414
C
GLN
A
416
47.377
−14.662
−2.355
1.00
22.17
A
C


ATOM
6415
O
GLN
A
416
48.115
−14.479
−3.326
1.00
23.08
A
O


ATOM
6417
N
LEU
A
417
46.557
−15.693
−2.258
1.00
22.31
A
N


ATOM
6418
CA
LEU
A
417
46.551
−16.738
−3.261
1.00
21.08
A
C


ATOM
6420
CB
LEU
A
417
45.990
−18.030
−2.654
1.00
21.91
A
C


ATOM
6423
CG
LEU
A
417
46.945
−18.669
−1.639
1.00
19.81
A
C


ATOM
6425
CD1
LEU
A
417
46.344
−19.945
−1.113
1.00
14.21
A
C


ATOM
6429
CD2
LEU
A
417
48.346
−18.927
−2.256
1.00
18.26
A
C


ATOM
6433
C
LEU
A
417
45.790
−16.309
−4.513
1.00
20.42
A
C


ATOM
6434
O
LEU
A
417
46.103
−16.788
−5.593
1.00
22.88
A
O


ATOM
6436
N
VAL
A
418
44.810
−15.411
−4.392
1.00
19.02
A
N


ATOM
6437
CA
VAL
A
418
44.225
−14.779
−5.577
1.00
18.67
A
C


ATOM
6439
CB
VAL
A
418
42.998
−13.900
−5.236
1.00
20.97
A
C


ATOM
6441
CG1
VAL
A
418
41.818
−14.753
−4.788
1.00
18.15
A
C


ATOM
6445
CG2
VAL
A
418
42.578
−13.054
−6.466
1.00
20.23
A
C


ATOM
6449
C
VAL
A
418
45.294
−13.951
−6.316
1.00
21.16
A
C


ATOM
6450
O
VAL
A
418
45.461
−14.083
−7.528
1.00
22.26
A
O


ATOM
6452
N
PHE
A
419
46.042
−13.109
−5.596
1.00
21.17
A
N


ATOM
6453
CA
PHE
A
419
47.119
−12.364
−6.258
1.00
21.54
A
C


ATOM
6455
CB
PHE
A
419
47.765
−11.331
−5.319
1.00
23.17
A
C


ATOM
6458
CG
PHE
A
419
46.958
−10.072
−5.184
1.00
21.42
A
C


ATOM
6459
CD1
PHE
A
419
47.326
−8.931
−5.865
1.00
22.64
A
C


ATOM
6461
CE1
PHE
A
419
46.556
−7.776
−5.772
1.00
25.28
A
C


ATOM
6463
CZ
PHE
A
419
45.400
−7.762
−5.000
1.00
19.63
A
C


ATOM
6465
CE2
PHE
A
419
45.006
−8.907
−4.339
1.00
19.52
A
C


ATOM
6467
CD2
PHE
A
419
45.780
−10.056
−4.431
1.00
16.56
A
C


ATOM
6469
C
PHE
A
419
48.170
−13.309
−6.836
1.00
23.38
A
C


ATOM
6470
O
PHE
A
419
48.675
−13.070
−7.931
1.00
25.01
A
O


ATOM
6472
N
ALA
A
420
48.485
−14.385
−6.112
1.00
23.32
A
N


ATOM
6473
CA
ALA
A
420
49.475
−15.361
−6.567
1.00
23.26
A
C


ATOM
6475
CB
ALA
A
420
49.690
−16.442
−5.494
1.00
23.21
A
C


ATOM
6479
C
ALA
A
420
49.055
−15.988
−7.887
1.00
23.77
A
C


ATOM
6480
O
ALA
A
420
49.844
−16.087
−8.828
1.00
25.95
A
O


ATOM
6482
N
TYR
A
421
47.794
−16.363
−7.978
1.00
23.54
A
N


ATOM
6483
CA
TYR
A
421
47.263
−16.960
−9.198
1.00
23.07
A
C


ATOM
6485
CB
TYR
A
421
45.749
−17.152
−9.089
1.00
21.91
A
C


ATOM
6488
CG
TYR
A
421
45.100
−17.619
−10.361
1.00
27.04
A
C


ATOM
6489
CD1
TYR
A
421
44.986
−18.967
−10.667
1.00
27.50
A
C


ATOM
6491
CE1
TYR
A
421
44.387
−19.382
−11.857
1.00
24.79
A
C


ATOM
6493
CZ
TYR
A
421
43.913
−18.448
−12.741
1.00
29.31
A
C


ATOM
6494
OH
TYR
A
421
43.313
−18.816
−13.933
1.00
31.42
A
O


ATOM
6496
CE2
TYR
A
421
44.033
−17.116
−12.450
1.00
27.45
A
C


ATOM
6498
CD2
TYR
A
421
44.619
−16.714
−11.274
1.00
28.49
A
C


ATOM
6500
C
TYR
A
421
47.595
−16.104
−10.417
1.00
24.43
A
C


ATOM
6501
O
TYR
A
421
48.121
−16.591
−11.394
1.00
24.22
A
O


ATOM
6503
N
PHE
A
422
47.276
−14.823
−10.369
1.00
26.68
A
N


ATOM
6504
CA
PHE
A
422
47.503
−13.956
−11.530
1.00
25.20
A
C


ATOM
6506
CB
PHE
A
422
46.767
−12.615
−11.366
1.00
24.18
A
C


ATOM
6509
CG
PHE
A
422
45.256
−12.751
−11.365
1.00
22.43
A
C


ATOM
6510
CD1
PHE
A
422
44.575
−13.050
−12.530
1.00
24.26
A
C


ATOM
6512
CE1
PHE
A
422
43.211
−13.195
−12.532
1.00
19.71
A
C


ATOM
6514
CZ
PHE
A
422
42.501
−13.018
−11.375
1.00
23.62
A
C


ATOM
6516
CE2
PHE
A
422
43.173
−12.692
−10.206
1.00
23.66
A
C


ATOM
6518
CD2
PHE
A
422
44.528
−12.584
−10.209
1.00
23.28
A
C


ATOM
6520
C
PHE
A
422
48.995
−13.758
−11.820
1.00
25.13
A
C


ATOM
6521
O
PHE
A
422
49.373
−13.524
−12.938
1.00
26.88
A
O


ATOM
6523
N
ALA
A
423
49.848
−13.890
−10.816
1.00
26.63
A
N


ATOM
6524
CA
ALA
A
423
51.276
−13.786
−11.044
1.00
25.44
A
C


ATOM
6526
CB
ALA
A
423
51.948
−13.230
−9.802
1.00
23.79
A
C


ATOM
6530
C
ALA
A
423
51.971
−15.094
−11.494
1.00
26.97
A
C


ATOM
6531
O
ALA
A
423
53.081
−15.036
−12.004
1.00
27.50
A
O


ATOM
6533
N
VAL
A
424
51.374
−16.264
−11.299
1.00
28.07
A
N


ATOM
6534
CA
VAL
A
424
52.066
−17.507
−11.685
1.00
29.42
A
C


ATOM
6536
CB
VAL
A
424
52.283
−18.495
−10.493
1.00
29.38
A
C


ATOM
6538
CG1
VAL
A
424
52.977
−17.799
−9.333
1.00
25.33
A
C


ATOM
6542
CG2
VAL
A
424
50.996
−19.113
−10.041
1.00
22.76
A
C


ATOM
6546
C
VAL
A
424
51.408
−18.251
−12.844
1.00
33.66
A
C


ATOM
6547
O
VAL
A
424
52.053
−19.079
−13.490
1.00
35.50
A
O


ATOM
6549
N
VAL
A
425
50.146
−17.965
−13.127
1.00
35.54
A
N


ATOM
6550
CA
VAL
A
425
49.462
−18.645
−14.216
1.00
39.97
A
C


ATOM
6552
CB
VAL
A
425
47.958
−18.802
−13.917
1.00
41.70
A
C


ATOM
6554
CG1
VAL
A
425
47.191
−19.173
−15.166
1.00
40.48
A
C


ATOM
6558
CG2
VAL
A
425
47.747
−19.848
−12.808
1.00
38.62
A
C


ATOM
6562
C
VAL
A
425
49.640
−17.919
−15.547
1.00
43.30
A
C


ATOM
6563
O
VAL
A
425
49.391
−16.728
−15.649
1.00
45.08
A
O


ATOM
6565
N
GLN
A
426
50.020
−18.681
−16.567
1.00
47.38
A
N


ATOM
6566
CA
GLN
A
426
50.299
−18.169
−17.911
1.00
50.63
A
C


ATOM
6568
CB
GLN
A
426
50.890
−19.311
−18.767
1.00
52.86
A
C


ATOM
6571
CG
GLN
A
426
51.846
−18.861
−19.889
1.00
62.22
A
C


ATOM
6574
CD
GLN
A
426
52.389
−20.034
−20.719
1.00
68.68
A
C


ATOM
6575
OE1
GLN
A
426
52.756
−21.079
−20.174
1.00
74.04
A
O


ATOM
6576
NE2
GLN
A
426
52.439
−19.857
−22.039
1.00
69.99
A
N


ATOM
6579
C
GLN
A
426
49.041
−17.602
−18.573
1.00
48.57
A
C


ATOM
6580
O
GLN
A
426
49.002
−16.441
−18.976
1.00
49.10
A
O


ATOM
6582
N
ASN
A
427
48.014
−18.437
−18.675
1.00
46.60
A
N


ATOM
6583
CA
ASN
A
427
46.748
−18.043
−19.265
1.00
44.60
A
C


ATOM
6585
CB
ASN
A
427
46.429
−18.906
−20.487
1.00
44.23
A
C


ATOM
6588
CG
ASN
A
427
47.362
−18.637
−21.657
1.00
46.94
A
C


ATOM
6589
OD1
ASN
A
427
47.181
−17.674
−22.416
1.00
45.67
A
O


ATOM
6590
ND2
ASN
A
427
48.363
−19.501
−21.818
1.00
41.48
A
N


ATOM
6593
C
ASN
A
427
45.649
−18.200
−18.231
1.00
42.84
A
C


ATOM
6594
O
ASN
A
427
45.421
−19.292
−17.709
1.00
42.87
A
O


ATOM
6596
N
ILE
A
428
44.957
−17.105
−17.973
1.00
40.25
A
N


ATOM
6597
CA
ILE
A
428
43.853
−17.067
−17.038
1.00
40.59
A
C


ATOM
6599
CB
ILE
A
428
43.459
−15.599
−16.777
1.00
41.62
A
C


ATOM
6601
CG1
ILE
A
428
44.629
−14.848
−16.128
1.00
40.01
A
C


ATOM
6604
CD1
ILE
A
428
44.658
−13.322
−16.465
1.00
35.27
A
C


ATOM
6608
CG2
ILE
A
428
42.222
−15.507
−15.910
1.00
44.80
A
C


ATOM
6612
C
ILE
A
428
42.693
−17.839
−17.658
1.00
41.08
A
C


ATOM
6613
O
ILE
A
428
42.553
−17.846
−18.880
1.00
42.37
A
O


ATOM
6615
N
LYS
A
429
41.896
−18.518
−16.832
1.00
40.25
A
N


ATOM
6616
CA
LYS
A
429
40.658
−19.174
−17.289
1.00
39.88
A
C


ATOM
6618
CB
LYS
A
429
40.765
−20.701
−17.218
1.00
40.54
A
C


ATOM
6621
CG
LYS
A
429
41.990
−21.287
−17.914
1.00
44.77
A
C


ATOM
6624
CD
LYS
A
429
42.057
−22.807
−17.758
1.00
51.10
A
C


ATOM
6627
CE
LYS
A
429
43.171
−23.422
−18.624
1.00
55.81
A
C


ATOM
6630
NZ
LYS
A
429
43.150
−24.926
−18.619
1.00
55.50
A
N


ATOM
6634
C
LYS
A
429
39.503
−18.725
−16.422
1.00
38.57
A
C


ATOM
6635
O
LYS
A
429
39.622
−18.686
−15.203
1.00
37.64
A
O


ATOM
6637
N
LYS
A
430
38.387
−18.402
−17.057
1.00
39.36
A
N


ATOM
6638
CA
LYS
A
430
37.202
−17.914
−16.377
1.00
41.11
A
C


ATOM
6640
CB
LYS
A
430
36.047
−17.755
−17.374
1.00
42.76
A
C


ATOM
6643
CG
LYS
A
430
34.811
−17.033
−16.805
1.00
52.15
A
C


ATOM
6646
CD
LYS
A
430
33.595
−17.025
−17.779
1.00
62.30
A
C


ATOM
6649
CE
LYS
A
430
33.214
−18.434
−18.289
1.00
67.69
A
C


ATOM
6652
NZ
LYS
A
430
33.285
−19.518
−17.240
1.00
70.45
A
N


ATOM
6656
C
LYS
A
430
36.760
−18.829
−15.242
1.00
39.57
A
C


ATOM
6657
O
LYS
A
430
36.417
−18.359
−14.164
1.00
40.96
A
O


ATOM
6659
N
GLU
A
431
36.750
−20.128
−15.481
1.00
38.13
A
N


ATOM
6660
CA
GLU
A
431
36.268
−21.066
−14.481
1.00
38.67
A
C


ATOM
6662
CB
GLU
A
431
36.170
−22.473
−15.077
1.00
40.19
A
C


ATOM
6665
CG
GLU
A
431
35.497
−23.511
−14.161
1.00
48.81
A
C


ATOM
6668
CD
GLU
A
431
35.757
−24.965
−14.584
1.00
61.18
A
C


ATOM
6669
OE1
GLU
A
431
36.689
−25.202
−15.394
1.00
63.32
A
O


ATOM
6670
OE2
GLU
A
431
35.035
−25.871
−14.094
1.00
62.58
A
O


ATOM
6671
C
GLU
A
431
37.190
−21.073
−13.259
1.00
36.48
A
C


ATOM
6672
O
GLU
A
431
36.734
−21.199
−12.129
1.00
36.23
A
O


ATOM
6674
N
GLU
A
432
38.488
−20.954
−13.497
1.00
33.62
A
N


ATOM
6675
CA
GLU
A
432
39.445
−20.894
−12.420
1.00
32.85
A
C


ATOM
6677
CB
GLU
A
432
40.866
−20.914
−12.983
1.00
33.14
A
C


ATOM
6680
CG
GLU
A
432
41.222
−22.249
−13.661
1.00
32.44
A
C


ATOM
6683
CD
GLU
A
432
42.707
−22.372
−14.031
1.00
39.53
A
C


ATOM
6684
OE1
GLU
A
432
43.375
−21.332
−14.238
1.00
36.98
A
O


ATOM
6685
OE2
GLU
A
432
43.201
−23.522
−14.119
1.00
43.09
A
O


ATOM
6686
C
GLU
A
432
39.184
−19.665
−11.532
1.00
32.20
A
C


ATOM
6687
O
GLU
A
432
39.045
−19.781
−10.320
1.00
30.88
A
O


ATOM
6689
N
ILE
A
433
39.068
−18.493
−12.134
1.00
32.33
A
N


ATOM
6690
CA
ILE
A
433
38.908
−17.281
−11.335
1.00
34.37
A
C


ATOM
6692
CB
ILE
A
433
39.317
−15.983
−12.109
1.00
33.78
A
C


ATOM
6694
CG1
ILE
A
433
38.480
−15.704
−13.327
1.00
38.66
A
C


ATOM
6697
CD1
ILE
A
433
39.103
−14.565
−14.169
1.00
38.73
A
C


ATOM
6701
CG2
ILE
A
433
40.739
−16.106
−12.614
1.00
35.34
A
C


ATOM
6705
C
ILE
A
433
37.524
−17.235
−10.645
1.00
33.31
A
C


ATOM
6706
O
ILE
A
433
37.414
−16.838
−9.485
1.00
33.97
A
O


ATOM
6708
N
GLU
A
434
36.501
−17.744
−11.305
1.00
30.95
A
N


ATOM
6709
CA
GLU
A
434
35.221
−17.944
−10.643
1.00
32.93
A
C


ATOM
6711
CB
GLU
A
434
34.242
−18.683
−11.551
1.00
33.75
A
C


ATOM
6714
CG
GLU
A
434
32.961
−17.939
−11.781
1.00
46.39
A
C


ATOM
6717
CD
GLU
A
434
33.044
−17.044
−12.995
1.00
58.82
A
C


ATOM
6718
OE1
GLU
A
434
32.768
−17.555
−14.111
1.00
63.42
A
O


ATOM
6719
OE2
GLU
A
434
33.383
−15.842
−12.828
1.00
62.69
A
O


ATOM
6720
C
GLU
A
434
35.349
−18.777
−9.367
1.00
31.62
A
C


ATOM
6721
O
GLU
A
434
34.681
−18.501
−8.378
1.00
30.48
A
O


ATOM
6723
N
ASN
A
435
36.149
−19.844
−9.428
1.00
29.51
A
N


ATOM
6724
CA
ASN
A
435
36.342
−20.710
−8.285
1.00
27.90
A
C


ATOM
6726
CB
ASN
A
435
36.878
−22.070
−8.714
1.00
28.27
A
C


ATOM
6729
CG
ASN
A
435
35.756
−23.015
−9.168
1.00
33.33
A
C


ATOM
6730
OD1
ASN
A
435
35.103
−23.671
−8.354
1.00
37.87
A
O


ATOM
6731
ND2
ASN
A
435
35.524
−23.063
−10.466
1.00
29.41
A
N


ATOM
6734
C
ASN
A
435
37.212
−20.060
−7.199
1.00
25.58
A
C


ATOM
6735
O
ASN
A
435
36.985
−20.285
−6.037
1.00
23.42
A
O


ATOM
6737
N
LEU
A
436
38.163
−19.221
−7.582
1.00
25.17
A
N


ATOM
6738
CA
LEU
A
436
38.861
−18.411
−6.597
1.00
27.41
A
C


ATOM
6740
CB
LEU
A
436
39.909
−17.535
−7.240
1.00
26.64
A
C


ATOM
6743
CG
LEU
A
436
41.090
−18.252
−7.868
1.00
26.99
A
C


ATOM
6745
CD1
LEU
A
436
42.017
−17.177
−8.425
1.00
26.84
A
C


ATOM
6749
CD2
LEU
A
436
41.819
−19.140
−6.861
1.00
23.22
A
C


ATOM
6753
C
LEU
A
436
37.892
−17.536
−5.800
1.00
28.45
A
C


ATOM
6754
O
LEU
A
436
37.991
−17.504
−4.587
1.00
29.36
A
O


ATOM
6756
N
GLN
A
437
36.936
−16.891
−6.465
1.00
30.08
A
N


ATOM
6757
CA
GLN
A
437
35.973
−16.014
−5.778
1.00
32.71
A
C


ATOM
6759
CB
GLN
A
437
35.120
−15.210
−6.760
1.00
34.60
A
C


ATOM
6762
CG
GLN
A
437
35.934
−14.322
−7.670
1.00
40.35
A
C


ATOM
6765
CD
GLN
A
437
35.165
−13.112
−8.186
1.00
41.37
A
C


ATOM
6766
OE1
GLN
A
437
34.156
−13.238
−8.889
1.00
39.37
A
O


ATOM
6767
NE2
GLN
A
437
35.667
−11.931
−7.865
1.00
36.34
A
N


ATOM
6770
C
GLN
A
437
35.034
−16.781
−4.887
1.00
32.09
A
C


ATOM
6771
O
GLN
A
437
34.485
−16.215
−3.930
1.00
31.31
A
O


ATOM
6773
N
LYS
A
438
34.824
−18.058
−5.192
1.00
31.99
A
N


ATOM
6774
CA
LYS
A
438
34.012
−18.893
−4.314
1.00
33.99
A
C


ATOM
6776
CB
LYS
A
438
33.202
−19.913
−5.124
1.00
35.73
A
C


ATOM
6779
CG
LYS
A
438
32.247
−19.275
−6.153
1.00
45.89
A
C


ATOM
6782
CD
LYS
A
438
31.513
−20.316
−7.024
1.00
55.14
A
C


ATOM
6785
CE
LYS
A
438
30.386
−19.644
−7.869
1.00
63.38
A
C


ATOM
6788
NZ
LYS
A
438
29.546
−20.589
−8.694
1.00
60.75
A
N


ATOM
6792
C
LYS
A
438
34.865
−19.586
−3.236
1.00
31.23
A
C


ATOM
6793
O
LYS
A
438
34.392
−20.495
−2.582
1.00
32.53
A
O


ATOM
6795
N
TYR
A
439
36.106
−19.154
−3.025
1.00
29.33
A
N


ATOM
6796
CA
TYR
A
439
36.987
−19.827
−2.037
1.00
30.37
A
C


ATOM
6798
CB
TYR
A
439
36.580
−19.469
−0.619
1.00
30.63
A
C


ATOM
6801
CG
TYR
A
439
36.618
−18.009
−0.425
1.00
34.45
A
C


ATOM
6802
CD1
TYR
A
439
37.797
−17.379
−0.140
1.00
34.10
A
C


ATOM
6804
CE1
TYR
A
439
37.843
−16.017
0.018
1.00
46.73
A
C


ATOM
6806
CZ
TYR
A
439
36.696
−15.271
−0.125
1.00
42.16
A
C


ATOM
6807
OH
TYR
A
439
36.764
−13.915
0.022
1.00
47.04
A
O


ATOM
6809
CE2
TYR
A
439
35.511
−15.873
−0.425
1.00
40.10
A
C


ATOM
6811
CD2
TYR
A
439
35.471
−17.237
−0.574
1.00
40.92
A
C


ATOM
6813
C
TYR
A
439
37.069
−21.348
−2.189
1.00
28.38
A
C


ATOM
6814
O
TYR
A
439
36.845
−22.103
−1.260
1.00
29.86
A
O


ATOM
6816
N
HIS
A
440
37.398
−21.772
−3.393
1.00
28.22
A
N


ATOM
6817
CA
HIS
A
440
37.588
−23.162
−3.706
1.00
27.43
A
C


ATOM
6819
CB
HIS
A
440
38.015
−23.245
−5.154
1.00
27.12
A
C


ATOM
6822
CG
HIS
A
440
38.138
−24.635
−5.681
1.00
32.93
A
C


ATOM
6823
ND1
HIS
A
440
39.347
−25.286
−5.776
1.00
33.95
A
N


ATOM
6825
CE1
HIS
A
440
39.159
−26.476
−6.317
1.00
37.85
A
C


ATOM
6827
NE2
HIS
A
440
37.873
−26.615
−6.576
1.00
39.10
A
N


ATOM
6829
CD2
HIS
A
440
37.213
−25.475
−6.197
1.00
32.98
A
C


ATOM
6831
C
HIS
A
440
38.672
−23.786
−2.837
1.00
28.12
A
C


ATOM
6832
O
HIS
A
440
39.654
−23.120
−2.456
1.00
28.00
A
O


ATOM
6834
N
ASP
A
441
38.503
−25.080
−2.588
1.00
26.13
A
N


ATOM
6835
CA
ASP
A
441
39.400
−25.896
−1.767
1.00
26.61
A
C


ATOM
6837
CB
ASP
A
441
39.147
−27.387
−2.031
1.00
27.37
A
C


ATOM
6840
CG
ASP
A
441
37.763
−27.853
−1.564
1.00
29.75
A
C


ATOM
6841
OD1
ASP
A
441
37.167
−27.195
−0.690
1.00
33.53
A
O


ATOM
6842
OD2
ASP
A
441
37.280
−28.881
−2.096
1.00
42.48
A
O


ATOM
6843
C
ASP
A
441
40.881
−25.637
−1.966
1.00
25.58
A
C


ATOM
6844
O
ASP
A
441
41.660
−25.729
−1.031
1.00
24.77
A
O


ATOM
6846
N
THR
A
442
41.277
−25.366
−3.193
1.00
24.56
A
N


ATOM
6847
CA
THR
A
442
42.673
−25.189
−3.491
1.00
25.67
A
C


ATOM
6849
CB
THR
A
442
42.868
−24.892
−4.992
1.00
27.90
A
C


ATOM
6851
OG1
THR
A
442
42.233
−25.923
−5.760
1.00
35.85
A
O


ATOM
6853
CG2
THR
A
442
44.321
−24.853
−5.349
1.00
30.00
A
C


ATOM
6857
C
THR
A
442
43.224
−24.046
−2.635
1.00
24.91
A
C


ATOM
6858
O
THR
A
442
44.337
−24.143
−2.151
1.00
25.25
A
O


ATOM
6860
N
ILE
A
443
42.444
−22.980
−2.426
1.00
22.84
A
N


ATOM
6861
CA
ILE
A
443
42.947
−21.824
−1.701
1.00
22.34
A
C


ATOM
6863
CB
ILE
A
443
42.756
−20.489
−2.471
1.00
22.85
A
C


ATOM
6865
CG1
ILE
A
443
41.323
−20.006
−2.467
1.00
21.22
A
C


ATOM
6868
CD1
ILE
A
443
41.213
−18.584
−3.057
1.00
21.90
A
C


ATOM
6872
CG2
ILE
A
443
43.241
−20.606
−3.900
1.00
18.47
A
C


ATOM
6876
C
ILE
A
443
42.392
−21.728
−0.294
1.00
23.52
A
C


ATOM
6877
O
ILE
A
443
43.045
−21.179
0.600
1.00
24.12
A
O


ATOM
6879
N
SER
A
444
41.229
−22.322
−0.060
1.00
24.10
A
N


ATOM
6880
CA
SER
A
444
40.649
−22.275
1.259
1.00
23.55
A
C


ATOM
6882
CB
SER
A
444
39.190
−22.705
1.213
1.00
25.69
A
C


ATOM
6885
OG
SER
A
444
39.087
−24.090
0.993
1.00
26.17
A
O


ATOM
6887
C
SER
A
444
41.453
−23.163
2.210
1.00
24.88
A
C


ATOM
6888
O
SER
A
444
41.745
−22.766
3.322
1.00
26.85
A
O


ATOM
6890
N
ARG
A
445
41.866
−24.344
1.776
1.00
22.69
A
N


ATOM
6891
CA
ARG
A
445
42.481
−25.273
2.732
1.00
23.70
A
C


ATOM
6893
CB
ARG
A
445
42.542
−26.686
2.164
1.00
24.49
A
C


ATOM
6896
CG
ARG
A
445
41.178
−27.309
2.168
1.00
24.68
A
C


ATOM
6899
CD
ARG
A
445
41.233
−28.614
1.536
1.00
35.00
A
C


ATOM
6902
NE
ARG
A
445
39.915
−29.227
1.462
1.00
41.73
A
N


ATOM
6904
CZ
ARG
A
445
39.533
−30.015
0.465
1.00
40.99
A
C


ATOM
6905
NH1
ARG
A
445
40.365
−30.263
−0.544
1.00
41.35
A
N


ATOM
6908
NH2
ARG
A
445
38.333
−30.562
0.478
1.00
38.98
A
N


ATOM
6911
C
ARG
A
445
43.820
−24.835
3.305
1.00
23.32
A
C


ATOM
6912
O
ARG
A
445
44.022
−24.930
4.514
1.00
23.11
A
O


ATOM
6914
N
PRO
A
446
44.722
−24.325
2.458
1.00
23.47
A
N


ATOM
6915
CA
PRO
A
446
45.955
−23.766
2.988
1.00
21.78
A
C


ATOM
6917
CB
PRO
A
446
46.703
−23.284
1.751
1.00
21.26
A
C


ATOM
6920
CG
PRO
A
446
46.082
−23.962
0.618
1.00
26.11
A
C


ATOM
6923
CD
PRO
A
446
44.688
−24.299
0.985
1.00
25.66
A
C


ATOM
6926
C
PRO
A
446
45.677
−22.599
3.903
1.00
20.98
A
C


ATOM
6927
O
PRO
A
446
46.397
−22.418
4.875
1.00
22.87
A
O


ATOM
6928
N
SER
A
447
44.620
−21.845
3.619
1.00
21.42
A
N


ATOM
6929
CA
SER
A
447
44.230
−20.731
4.469
1.00
20.70
A
C


ATOM
6931
CB
SER
A
447
43.183
−19.827
3.806
1.00
21.82
A
C


ATOM
6934
OG
SER
A
447
43.690
−19.313
2.556
1.00
20.36
A
O


ATOM
6936
C
SER
A
447
43.777
−21.209
5.822
1.00
22.31
A
C


ATOM
6937
O
SER
A
447
44.075
−20.554
6.820
1.00
23.84
A
O


ATOM
6939
N
HIS
A
448
43.104
−22.358
5.876
1.00
21.04
A
N


ATOM
6940
CA
HIS
A
448
42.712
−22.952
7.144
1.00
20.19
A
C


ATOM
6942
CB
HIS
A
448
42.004
−24.317
6.968
1.00
21.41
A
C


ATOM
6945
CG
HIS
A
448
40.675
−24.253
6.277
1.00
21.38
A
C


ATOM
6946
ND1
HIS
A
448
39.944
−25.382
5.969
1.00
29.82
A
N


ATOM
6948
CE1
HIS
A
448
38.812
−25.025
5.382
1.00
29.77
A
C


ATOM
6950
NE2
HIS
A
448
38.790
−23.705
5.289
1.00
24.12
A
N


ATOM
6952
CD2
HIS
A
448
39.939
−23.202
5.844
1.00
24.45
A
C


ATOM
6954
C
HIS
A
448
43.959
−23.180
7.969
1.00
20.74
A
C


ATOM
6955
O
HIS
A
448
44.002
−22.864
9.156
1.00
21.08
A
O


ATOM
6957
N
ILE
A
449
44.979
−23.756
7.340
1.00
23.35
A
N


ATOM
6958
CA
ILE
A
449
46.212
−24.095
8.052
1.00
23.10
A
C


ATOM
6960
CB
ILE
A
449
47.188
−24.850
7.162
1.00
24.84
A
C


ATOM
6962
CG1
ILE
A
449
46.563
−26.145
6.663
1.00
26.29
A
C


ATOM
6965
CD1
ILE
A
449
46.302
−27.059
7.721
1.00
29.80
A
C


ATOM
6969
CG2
ILE
A
449
48.490
−25.168
7.926
1.00
20.98
A
C


ATOM
6973
C
ILE
A
449
46.928
−22.848
8.571
1.00
22.77
A
C


ATOM
6974
O
ILE
A
449
47.479
−22.863
9.658
1.00
23.35
A
O


ATOM
6976
N
PHE
A
450
46.918
−21.796
7.764
1.00
22.40
A
N


ATOM
6977
CA
PHE
A
450
47.527
−20.514
8.097
1.00
23.32
A
C


ATOM
6979
CB
PHE
A
450
47.411
−19.599
6.857
1.00
25.81
A
C


ATOM
6982
CG
PHE
A
450
47.936
−18.168
7.029
1.00
26.15
A
C


ATOM
6983
CD1
PHE
A
450
48.744
−17.792
8.083
1.00
29.10
A
C


ATOM
6985
CE1
PHE
A
450
49.178
−16.483
8.205
1.00
27.29
A
C


ATOM
6987
CZ
PHE
A
450
48.850
−15.548
7.238
1.00
27.02
A
C


ATOM
6989
CE2
PHE
A
450
48.056
−15.914
6.167
1.00
30.51
A
C


ATOM
6991
CD2
PHE
A
450
47.625
−17.214
6.062
1.00
23.58
A
C


ATOM
6993
C
PHE
A
450
46.854
−19.966
9.342
1.00
22.59
A
C


ATOM
6994
O
PHE
A
450
47.505
−19.733
10.370
1.00
23.10
A
O


ATOM
6996
N
ARG
A
451
45.538
−19.856
9.327
1.00
22.00
A
N


ATOM
6997
CA
ARG
A
451
44.884
−19.370
10.531
1.00
22.22
A
C


ATOM
6999
CB
ARG
A
451
43.396
−19.215
10.307
1.00
20.08
A
C


ATOM
7002
CG
ARG
A
451
42.583
−18.918
11.559
1.00
20.62
A
C


ATOM
7005
CD
ARG
A
451
43.123
−17.713
12.310
1.00
20.48
A
C


ATOM
7008
NE
ARG
A
451
43.009
−16.489
11.536
1.00
22.29
A
N


ATOM
7010
CZ
ARG
A
451
43.506
−15.318
11.908
1.00
22.48
A
C


ATOM
7011
NH1
ARG
A
451
44.207
−15.207
13.027
1.00
20.34
A
N


ATOM
7014
NH2
ARG
A
451
43.317
−14.259
11.149
1.00
22.06
A
N


ATOM
7017
C
ARG
A
451
45.183
−20.281
11.740
1.00
22.94
A
C


ATOM
7018
O
ARG
A
451
45.522
−19.806
12.825
1.00
22.52
A
O


ATOM
7020
N
LEU
A
452
45.044
−21.587
11.561
1.00
23.09
A
N


ATOM
7021
CA
LEU
A
452
45.208
−22.500
12.700
1.00
22.53
A
C


ATOM
7023
CB
LEU
A
452
44.799
−23.931
12.332
1.00
19.50
A
C


ATOM
7026
CG
LEU
A
452
43.313
−24.152
12.034
1.00
22.38
A
C


ATOM
7028
CD1
LEU
A
452
43.089
−25.564
11.548
1.00
17.99
A
C


ATOM
7032
CD2
LEU
A
452
42.403
−23.854
13.257
1.00
20.44
A
C


ATOM
7036
C
LEU
A
452
46.632
−22.453
13.278
1.00
22.42
A
C


ATOM
7037
O
LEU
A
452
46.793
−22.522
14.485
1.00
24.48
A
O


ATOM
7039
N
CYS
A
453
47.656
−22.340
12.433
1.00
22.44
A
N


ATOM
7040
CA
CYS
A
453
49.031
−22.312
12.933
1.00
24.59
A
C


ATOM
7042
CB
CYS
A
453
50.051
−22.425
11.804
1.00
26.01
A
C


ATOM
7045
SG
CYS
A
453
50.255
−24.066
11.075
1.00
27.17
A
S


ATOM
7047
C
CYS
A
453
49.283
−21.015
13.709
1.00
28.20
A
C


ATOM
7048
O
CYS
A
453
49.935
−21.023
14.753
1.00
31.95
A
O


ATOM
7050
N
ASN
A
454
48.768
−19.901
13.184
1.00
28.25
A
N


ATOM
7051
CA
ASN
A
454
48.874
−18.600
13.832
1.00
25.74
A
C


ATOM
7053
CB
ASN
A
454
48.292
−17.509
12.914
1.00
25.90
A
C


ATOM
7056
CG
ASN
A
454
48.465
−16.083
13.470
1.00
26.47
A
C


ATOM
7057
OD1
ASN
A
454
48.991
−15.875
14.552
1.00
40.48
A
O


ATOM
7058
ND2
ASN
A
454
48.002
−15.108
12.715
1.00
31.43
A
N


ATOM
7061
C
ASN
A
454
48.183
−18.595
15.180
1.00
26.43
A
C


ATOM
7062
O
ASN
A
454
48.774
−18.191
16.180
1.00
28.40
A
O


ATOM
7064
N
ASP
A
455
46.927
−19.024
15.205
1.00
26.39
A
N


ATOM
7065
CA
ASP
A
455
46.154
−19.022
16.434
1.00
25.96
A
C


ATOM
7067
CB
ASP
A
455
44.695
−19.399
16.185
1.00
26.38
A
C


ATOM
7070
CG
ASP
A
455
43.848
−18.229
15.635
1.00
30.58
A
C


ATOM
7071
OD1
ASP
A
455
44.407
−17.210
15.161
1.00
23.66
A
O


ATOM
7072
OD2
ASP
A
455
42.597
−18.359
15.672
1.00
27.94
A
O


ATOM
7073
C
ASP
A
455
46.775
−19.977
17.451
1.00
28.81
A
C


ATOM
7074
O
ASP
A
455
46.716
−19.705
18.659
1.00
29.70
A
O


ATOM
7076
N
LEU
A
456
47.368
−21.081
16.982
1.00
28.29
A
N


ATOM
7077
CA
LEU
A
456
48.072
−21.997
17.886
1.00
29.09
A
C


ATOM
7079
CB
LEU
A
456
48.609
−23.237
17.180
1.00
28.53
A
C


ATOM
7082
CG
LEU
A
456
47.613
−24.345
16.893
1.00
30.92
A
C


ATOM
7084
CD1
LEU
A
456
48.213
−25.380
15.920
1.00
27.62
A
C


ATOM
7088
CD2
LEU
A
456
47.182
−24.972
18.197
1.00
26.10
A
C


ATOM
7092
C
LEU
A
456
49.240
−21.292
18.552
1.00
30.48
A
C


ATOM
7093
O
LEU
A
456
49.465
−21.492
19.733
1.00
30.20
A
O


ATOM
7095
N
ALA
A
457
49.965
−20.458
17.807
1.00
30.94
A
N


ATOM
7096
CA
ALA
A
457
51.170
−19.838
18.350
1.00
30.89
A
C


ATOM
7098
CB
ALA
A
457
51.906
−19.078
17.293
1.00
28.28
A
C


ATOM
7102
C
ALA
A
457
50.847
−18.917
19.515
1.00
32.02
A
C


ATOM
7103
O
ALA
A
457
51.601
−18.841
20.466
1.00
34.01
A
O


ATOM
7105
N
SER
A
458
49.728
−18.222
19.441
1.00
34.20
A
N


ATOM
7106
CA
SER
A
458
49.383
−17.264
20.468
1.00
35.38
A
C


ATOM
7108
CB
SER
A
458
48.963
−15.943
19.823
1.00
36.92
A
C


ATOM
7111
OG
SER
A
458
47.792
−16.106
19.042
1.00
42.95
A
O


ATOM
7113
C
SER
A
458
48.282
−17.746
21.385
1.00
34.92
A
C


ATOM
7114
O
SER
A
458
47.901
−17.026
22.295
1.00
37.00
A
O


ATOM
7116
N
ALA
A
459
47.772
−18.955
21.178
1.00
34.97
A
N


ATOM
7117
CA
ALA
A
459
46.608
−19.381
21.934
1.00
34.82
A
C


ATOM
7119
CB
ALA
A
459
46.246
−20.833
21.642
1.00
33.75
A
C


ATOM
7123
C
ALA
A
459
46.827
−19.195
23.424
1.00
36.34
A
C


ATOM
7124
O
ALA
A
459
46.042
−18.506
24.078
1.00
34.86
A
O


ATOM
7126
N
SER
A
460
47.892
−19.805
23.948
1.00
39.24
A
N


ATOM
7127
CA
SER
A
460
48.081
−19.909
25.403
1.00
42.73
A
C


ATOM
7129
CB
SER
A
460
49.266
−20.832
25.765
1.00
43.60
A
C


ATOM
7132
OG
SER
A
460
50.520
−20.221
25.514
1.00
50.63
A
O


ATOM
7134
C
SER
A
460
48.188
−18.543
26.093
1.00
42.82
A
C


ATOM
7135
O
SER
A
460
47.591
−18.342
27.150
1.00
45.33
A
O


ATOM
7137
N
ALA
A
461
48.894
−17.598
25.482
1.00
43.05
A
N


ATOM
7138
CA
ALA
A
461
49.000
−16.245
26.037
1.00
43.65
A
C


ATOM
7140
CB
ALA
A
461
50.032
−15.414
25.263
1.00
42.89
A
C


ATOM
7144
C
ALA
A
461
47.647
−15.539
26.035
1.00
44.95
A
C


ATOM
7145
O
ALA
A
461
47.237
−14.969
27.045
1.00
46.39
A
O


ATOM
7147
N
GLU
A
462
46.947
−15.588
24.905
1.00
45.01
A
N


ATOM
7148
CA
GLU
A
462
45.666
−14.906
24.787
1.00
43.89
A
C


ATOM
7150
CB
GLU
A
462
45.159
−14.966
23.346
1.00
44.36
A
C


ATOM
7153
CG
GLU
A
462
46.045
−14.140
22.394
1.00
46.73
A
C


ATOM
7156
CD
GLU
A
462
45.617
−14.211
20.936
1.00
48.39
A
C


ATOM
7157
OE1
GLU
A
462
44.548
−14.792
20.655
1.00
52.33
A
O


ATOM
7158
OE2
GLU
A
462
46.361
−13.686
20.071
1.00
51.40
A
O


ATOM
7159
C
GLU
A
462
44.653
−15.472
25.763
1.00
42.95
A
C


ATOM
7160
O
GLU
A
462
43.856
−14.731
26.336
1.00
43.58
A
O


ATOM
7162
N
ILE
A
463
44.710
−16.776
25.985
1.00
42.70
A
N


ATOM
7163
CA
ILE
A
463
43.782
−17.436
26.897
1.00
44.06
A
C


ATOM
7165
CB
ILE
A
463
43.862
−18.971
26.773
1.00
43.11
A
C


ATOM
7167
CG1
ILE
A
463
43.216
−19.427
25.461
1.00
43.65
A
C


ATOM
7170
CD1
ILE
A
463
43.585
−20.854
25.026
1.00
35.99
A
C


ATOM
7174
CG2
ILE
A
463
43.180
−19.641
27.948
1.00
43.57
A
C


ATOM
7178
C
ILE
A
463
44.055
−17.028
28.344
1.00
46.68
A
C


ATOM
7179
O
ILE
A
463
43.119
−16.877
29.134
1.00
47.89
A
O


ATOM
7181
N
ALA
A
464
45.334
−16.854
28.678
1.00
47.67
A
N


ATOM
7182
CA
ALA
A
464
45.744
−16.469
30.028
1.00
48.52
A
C


ATOM
7184
CB
ALA
A
464
47.240
−16.690
30.214
1.00
47.57
A
C


ATOM
7188
C
ALA
A
464
45.365
−15.013
30.335
1.00
49.52
A
C


ATOM
7189
O
ALA
A
464
45.060
−14.690
31.477
1.00
49.39
A
O


ATOM
7191
N
ARG
A
465
45.362
−14.153
29.311
1.00
50.44
A
N


ATOM
7192
CA
ARG
A
465
44.869
−12.768
29.442
1.00
51.06
A
C


ATOM
7194
CB
ARG
A
465
45.373
−11.889
28.285
1.00
51.52
A
C


ATOM
7197
CG
ARG
A
465
46.878
−11.770
28.142
1.00
55.59
A
C


ATOM
7200
CD
ARG
A
465
47.250
−10.670
27.135
1.00
58.49
A
C


ATOM
7203
NE
ARG
A
465
48.351
−11.095
26.268
1.00
64.38
A
N


ATOM
7205
CZ
ARG
A
465
48.272
−11.296
24.947
1.00
68.81
A
C


ATOM
7206
NH1
ARG
A
465
47.138
−11.087
24.269
1.00
68.12
A
N


ATOM
7209
NH2
ARG
A
465
49.356
−11.696
24.282
1.00
69.02
A
N


ATOM
7212
C
ARG
A
465
43.330
−12.663
29.474
1.00
50.68
A
C


ATOM
7213
O
ARG
A
465
42.785
−11.559
29.542
1.00
50.12
A
O


ATOM
7215
N
GLY
A
466
42.635
−13.795
29.397
1.00
51.02
A
N


ATOM
7216
CA
GLY
A
466
41.175
−13.811
29.340
1.00
50.69
A
C


ATOM
7219
C
GLY
A
466
40.582
−13.347
28.015
1.00
49.88
A
C


ATOM
7220
O
GLY
A
466
39.478
−12.817
27.989
1.00
50.15
A
O


ATOM
7222
N
GLU
A
467
41.304
−13.545
26.914
1.00
49.42
A
N


ATOM
7223
CA
GLU
A
467
40.783
−13.204
25.591
1.00
48.91
A
C


ATOM
7225
CB
GLU
A
467
41.897
−12.706
24.677
1.00
49.79
A
C


ATOM
7228
CG
GLU
A
467
42.400
−11.308
25.017
1.00
54.31
A
C


ATOM
7231
CD
GLU
A
467
43.488
−10.836
24.059
1.00
62.07
A
C


ATOM
7232
OE1
GLU
A
467
43.370
−11.106
22.831
1.00
58.12
A
O


ATOM
7233
OE2
GLU
A
467
44.457
−10.198
24.543
1.00
65.78
A
O


ATOM
7234
C
GLU
A
467
40.046
−14.372
24.923
1.00
46.84
A
C


ATOM
7235
O
GLU
A
467
40.258
−15.543
25.245
1.00
46.20
A
O


ATOM
7237
N
THR
A
468
39.182
−14.009
23.983
1.00
44.02
A
N


ATOM
7238
CA
THR
A
468
38.326
−14.934
23.255
1.00
41.85
A
C


ATOM
7240
CB
THR
A
468
36.893
−14.390
23.234
1.00
41.87
A
C


ATOM
7242
OG1
THR
A
468
36.268
−14.693
24.475
1.00
44.70
A
O


ATOM
7244
CG2
THR
A
468
36.079
−14.983
22.064
1.00
43.08
A
C


ATOM
7248
C
THR
A
468
38.732
−15.112
21.793
1.00
39.84
A
C


ATOM
7249
O
THR
A
468
38.459
−16.149
21.206
1.00
40.48
A
O


ATOM
7251
N
ALA
A
469
39.366
−14.098
21.210
1.00
36.45
A
N


ATOM
7252
CA
ALA
A
469
39.501
−14.004
19.772
1.00
35.32
A
C


ATOM
7254
CB
ALA
A
469
39.721
−12.524
19.353
1.00
34.04
A
C


ATOM
7258
C
ALA
A
469
40.636
−14.890
19.278
1.00
32.68
A
C


ATOM
7259
O
ALA
A
469
41.677
−14.392
18.837
1.00
33.79
A
O


ATOM
7261
N
ASN
A
470
40.399
−16.201
19.338
1.00
29.47
A
N


ATOM
7262
CA
ASN
A
470
41.373
−17.233
18.951
1.00
27.64
A
C


ATOM
7264
CB
ASN
A
470
42.374
−17.461
20.088
1.00
27.10
A
C


ATOM
7267
CG
ASN
A
470
43.550
−18.304
19.660
1.00
28.28
A
C


ATOM
7268
OD1
ASN
A
470
43.450
−19.524
19.605
1.00
34.80
A
O


ATOM
7269
ND2
ASN
A
470
44.676
−17.657
19.346
1.00
30.77
A
N


ATOM
7272
C
ASN
A
470
40.651
−18.546
18.607
1.00
27.38
A
C


ATOM
7273
O
ASN
A
470
39.675
−18.909
19.274
1.00
28.84
A
O


ATOM
7275
N
SER
A
471
41.115
−19.259
17.580
1.00
25.73
A
N


ATOM
7276
CA
SER
A
471
40.413
−20.476
17.127
1.00
25.56
A
C


ATOM
7278
CB
SER
A
471
41.033
−21.026
15.831
1.00
24.86
A
C


ATOM
7281
OG
SER
A
471
40.941
−20.066
14.773
1.00
24.10
A
O


ATOM
7283
C
SER
A
471
40.387
−21.555
18.208
1.00
25.57
A
C


ATOM
7284
O
SER
A
471
39.370
−22.234
18.392
1.00
28.49
A
O


ATOM
7286
N
VAL
A
472
41.487
−21.689
18.940
1.00
24.63
A
N


ATOM
7287
CA
VAL
A
472
41.573
−22.638
20.058
1.00
24.83
A
C


ATOM
7289
CB
VAL
A
472
42.976
−22.647
20.681
1.00
24.78
A
C


ATOM
7291
CG1
VAL
A
472
43.062
−23.699
21.804
1.00
24.97
A
C


ATOM
7295
CG2
VAL
A
472
44.025
−22.919
19.612
1.00
24.81
A
C


ATOM
7299
C
VAL
A
472
40.585
−22.302
21.161
1.00
25.99
A
C


ATOM
7300
O
VAL
A
472
39.878
−23.166
21.682
1.00
27.14
A
O


ATOM
7302
N
SER
A
473
40.548
−21.027
21.517
1.00
28.17
A
N


ATOM
7303
CA
SER
A
473
39.639
−20.538
22.539
1.00
27.38
A
C


ATOM
7305
CB
SER
A
473
39.877
−19.048
22.775
1.00
28.17
A
C


ATOM
7308
OG
SER
A
473
38.904
−18.546
23.666
1.00
36.50
A
O


ATOM
7310
C
SER
A
473
38.199
−20.785
22.134
1.00
26.74
A
C


ATOM
7311
O
SER
A
473
37.391
−21.244
22.942
1.00
26.77
A
O


ATOM
7313
N
CYS
A
474
37.872
−20.526
20.874
1.00
26.84
A
N


ATOM
7314
CA
CYS
A
474
36.513
−20.796
20.410
1.00
27.97
A
C


ATOM
7316
CB
CYS
A
474
36.248
−20.181
19.037
1.00
28.57
A
C


ATOM
7319
SG
CYS
A
474
36.094
−18.392
19.116
1.00
37.03
A
S


ATOM
7321
C
CYS
A
474
36.219
−22.290
20.396
1.00
27.00
A
C


ATOM
7322
O
CYS
A
474
35.094
−22.698
20.680
1.00
27.66
A
O


ATOM
7324
N
TYR
A
475
37.221
−23.106
20.076
1.00
26.04
A
N


ATOM
7325
CA
TYR
A
475
37.015
−24.547
20.082
1.00
25.17
A
C


ATOM
7327
CB
TYR
A
475
38.209
−25.290
19.486
1.00
24.75
A
C


ATOM
7330
CG
TYR
A
475
37.853
−26.656
18.929
1.00
28.24
A
C


ATOM
7331
CD1
TYR
A
475
37.516
−26.821
17.587
1.00
32.56
A
C


ATOM
7333
CE1
TYR
A
475
37.192
−28.071
17.081
1.00
36.43
A
C


ATOM
7335
CZ
TYR
A
475
37.199
−29.178
17.923
1.00
34.35
A
C


ATOM
7336
OH
TYR
A
475
36.886
−30.419
17.441
1.00
43.05
A
O


ATOM
7338
CE2
TYR
A
475
37.533
−29.045
19.246
1.00
34.85
A
C


ATOM
7340
CD2
TYR
A
475
37.858
−27.783
19.747
1.00
34.43
A
C


ATOM
7342
C
TYR
A
475
36.749
−25.003
21.518
1.00
26.37
A
C


ATOM
7343
O
TYR
A
475
35.869
−25.833
21.752
1.00
27.21
A
O


ATOM
7345
N
MET
A
476
37.481
−24.438
22.479
1.00
26.99
A
N


ATOM
7346
CA
MET
A
476
37.252
−24.759
23.901
1.00
26.98
A
C


ATOM
7348
CB
MET
A
476
38.202
−23.971
24.789
1.00
26.60
A
C


ATOM
7351
CG
MET
A
476
39.652
−24.384
24.656
1.00
30.73
A
C


ATOM
7354
SD
MET
A
476
40.740
−23.174
25.392
1.00
36.77
A
S


ATOM
7355
CE
MET
A
476
39.937
−22.903
26.995
1.00
30.88
A
C


ATOM
7359
C
MET
A
476
35.826
−24.444
24.319
1.00
26.91
A
C


ATOM
7360
O
MET
A
476
35.137
−25.270
24.911
1.00
28.08
A
O


ATOM
7362
N
ARG
A
477
35.386
−23.237
24.009
1.00
28.18
A
N


ATOM
7363
CA
ARG
A
477
34.058
−22.797
24.398
1.00
29.26
A
C


ATOM
7365
CB
ARG
A
477
33.880
−21.314
24.079
1.00
28.98
A
C


ATOM
7368
CG
ARG
A
477
32.520
−20.733
24.449
1.00
32.12
A
C


ATOM
7371
CD
ARG
A
477
32.537
−19.223
24.275
1.00
40.29
A
C


ATOM
7374
NE
ARG
A
477
32.786
−18.815
22.888
1.00
44.21
A
N


ATOM
7376
CZ
ARG
A
477
33.290
−17.637
22.514
1.00
46.88
A
C


ATOM
7377
NH1
ARG
A
477
33.619
−16.721
23.420
1.00
48.90
A
N


ATOM
7380
NH2
ARG
A
477
33.469
−17.371
21.222
1.00
45.48
A
N


ATOM
7383
C
ARG
A
477
32.971
−23.620
23.702
1.00
29.87
A
C


ATOM
7384
O
ARG
A
477
32.006
−24.035
24.352
1.00
31.04
A
O


ATOM
7386
N
THR
A
478
33.110
−23.852
22.397
1.00
28.61
A
N


ATOM
7387
CA
THR
A
478
32.044
−24.539
21.657
1.00
28.83
A
C


ATOM
7389
CB
THR
A
478
32.216
−24.430
20.131
1.00
28.55
A
C


ATOM
7391
OG1
THR
A
478
32.238
−23.056
19.746
1.00
26.42
A
O


ATOM
7393
CG2
THR
A
478
31.034
−25.107
19.407
1.00
30.41
A
C


ATOM
7397
C
THR
A
478
31.911
−26.014
22.075
1.00
28.98
A
C


ATOM
7398
O
THR
A
478
30.822
−26.467
22.400
1.00
28.85
A
O


ATOM
7400
N
LYS
A
479
33.013
−26.758
22.074
1.00
29.87
A
N


ATOM
7401
CA
LYS
A
479
32.969
−28.157
22.516
1.00
30.10
A
C


ATOM
7403
CB
LYS
A
479
34.143
−28.960
21.938
1.00
30.29
A
C


ATOM
7406
CG
LYS
A
479
34.249
−28.964
20.406
1.00
33.64
A
C


ATOM
7409
CD
LYS
A
479
33.118
−29.688
19.695
1.00
42.31
A
C


ATOM
7412
CE
LYS
A
479
33.306
−29.581
18.174
1.00
47.79
A
C


ATOM
7415
NZ
LYS
A
479
32.463
−30.535
17.381
1.00
47.97
A
N


ATOM
7419
C
LYS
A
479
32.936
−28.290
24.057
1.00
30.88
A
C


ATOM
7420
O
LYS
A
479
32.660
−29.360
24.576
1.00
30.47
A
O


ATOM
7422
N
GLY
A
480
33.223
−27.207
24.781
1.00
31.72
A
N


ATOM
7423
CA
GLY
A
480
33.206
−27.231
26.248
1.00
31.97
A
C


ATOM
7426
C
GLY
A
480
34.311
−28.088
26.843
1.00
31.96
A
C


ATOM
7427
O
GLY
A
480
34.044
−28.932
27.722
1.00
31.49
A
O


ATOM
7429
N
ILE
A
481
35.544
−27.847
26.382
1.00
29.64
A
N


ATOM
7430
CA
ILE
A
481
36.702
−28.660
26.747
1.00
29.31
A
C


ATOM
7432
CB
ILE
A
481
37.044
−29.668
25.621
1.00
29.72
A
C


ATOM
7434
CG1
ILE
A
481
37.398
−28.940
24.302
1.00
30.04
A
C


ATOM
7437
CD1
ILE
A
481
37.581
−29.865
23.094
1.00
25.37
A
C


ATOM
7441
CG2
ILE
A
481
35.865
−30.602
25.391
1.00
29.26
A
C


ATOM
7445
C
ILE
A
481
37.926
−27.807
27.052
1.00
31.21
A
C


ATOM
7446
O
ILE
A
481
37.964
−26.613
26.746
1.00
32.82
A
O


ATOM
7448
N
SER
A
482
38.939
−28.439
27.634
1.00
32.10
A
N


ATOM
7449
CA
SER
A
482
40.162
−27.756
28.052
1.00
31.77
A
C


ATOM
7451
CB
SER
A
482
41.010
−28.718
28.874
1.00
32.78
A
C


ATOM
7454
OG
SER
A
482
41.130
−29.963
28.191
1.00
34.52
A
O


ATOM
7456
C
SER
A
482
41.000
−27.281
26.883
1.00
32.56
A
C


ATOM
7457
O
SER
A
482
40.839
−27.765
25.763
1.00
35.17
A
O


ATOM
7459
N
GLU
A
483
41.931
−26.369
27.161
1.00
32.02
A
N


ATOM
7460
CA
GLU
A
483
42.928
−25.941
26.186
1.00
33.48
A
C


ATOM
7462
CB
GLU
A
483
43.916
−24.948
26.815
1.00
33.20
A
C


ATOM
7465
CG
GLU
A
483
45.047
−24.524
25.877
1.00
33.67
A
C


ATOM
7468
CD
GLU
A
483
45.858
−23.351
26.389
1.00
40.22
A
C


ATOM
7469
OE1
GLU
A
483
45.594
−22.861
27.519
1.00
43.03
A
O


ATOM
7470
OE2
GLU
A
483
46.774
−22.916
25.657
1.00
38.81
A
O


ATOM
7471
C
GLU
A
483
43.714
−27.102
25.558
1.00
35.98
A
C


ATOM
7472
O
GLU
A
483
43.954
−27.120
24.335
1.00
37.13
A
O


ATOM
7474
N
GLU
A
484
44.134
−28.045
26.393
1.00
36.43
A
N


ATOM
7475
CA
GLU
A
484
44.980
−29.149
25.948
1.00
37.19
A
C


ATOM
7477
CB
GLU
A
484
45.523
−29.932
27.153
1.00
39.57
A
C


ATOM
7480
CG
GLU
A
484
46.686
−30.866
26.813
1.00
49.47
A
C


ATOM
7483
CD
GLU
A
484
47.292
−31.543
28.041
1.00
62.43
A
C


ATOM
7484
OE1
GLU
A
484
47.606
−30.824
29.026
1.00
66.87
A
O


ATOM
7485
OE2
GLU
A
484
47.459
−32.791
28.014
1.00
63.06
A
O


ATOM
7486
C
GLU
A
484
44.226
−30.084
25.005
1.00
35.28
A
C


ATOM
7487
O
GLU
A
484
44.768
−30.493
23.976
1.00
33.82
A
O


ATOM
7489
N
LEU
A
485
42.989
−30.433
25.351
1.00
33.95
A
N


ATOM
7490
CA
LEU
A
485
42.175
−31.227
24.425
1.00
33.76
A
C


ATOM
7492
CB
LEU
A
485
40.886
−31.745
25.069
1.00
34.55
A
C


ATOM
7495
CG
LEU
A
485
40.968
−33.207
25.551
1.00
39.74
A
C


ATOM
7497
CD1
LEU
A
485
42.126
−33.394
26.541
1.00
40.89
A
C


ATOM
7501
CD2
LEU
A
485
39.647
−33.669
26.180
1.00
42.87
A
C


ATOM
7505
C
LEU
A
485
41.870
−30.436
23.155
1.00
32.05
A
C


ATOM
7506
O
LEU
A
485
41.963
−30.972
22.062
1.00
30.76
A
O


ATOM
7508
N
ALA
A
486
41.522
−29.164
23.308
1.00
30.65
A
N


ATOM
7509
CA
ALA
A
486
41.225
−28.305
22.164
1.00
29.72
A
C


ATOM
7511
CB
ALA
A
486
40.771
−26.933
22.648
1.00
28.94
A
C


ATOM
7515
C
ALA
A
486
42.435
−28.176
21.228
1.00
30.16
A
C


ATOM
7516
O
ALA
A
486
42.310
−28.256
19.998
1.00
32.78
A
O


ATOM
7518
N
THR
A
487
43.607
−27.990
21.816
1.00
29.51
A
N


ATOM
7519
CA
THR
A
487
44.836
−27.889
21.068
1.00
29.35
A
C


ATOM
7521
CB
THR
A
487
46.016
−27.585
22.018
1.00
31.65
A
C


ATOM
7523
OG1
THR
A
487
45.866
−26.262
22.551
1.00
34.58
A
O


ATOM
7525
CG2
THR
A
487
47.356
−27.676
21.303
1.00
29.45
A
C


ATOM
7529
C
THR
A
487
45.083
−29.179
20.293
1.00
30.58
A
C


ATOM
7530
O
THR
A
487
45.510
−29.148
19.136
1.00
30.56
A
O


ATOM
7532
N
GLU
A
488
44.778
−30.311
20.912
1.00
30.73
A
N


ATOM
7533
CA
GLU
A
488
44.909
−31.596
20.251
1.00
31.69
A
C


ATOM
7535
CB
GLU
A
488
44.559
−32.726
21.226
1.00
34.61
A
C


ATOM
7538
CG
GLU
A
488
44.929
−34.158
20.782
1.00
42.91
A
C


ATOM
7541
CD
GLU
A
488
44.468
−35.230
21.805
1.00
51.83
A
C


ATOM
7542
OE1
GLU
A
488
45.312
−36.038
22.257
1.00
53.97
A
O


ATOM
7543
OE2
GLU
A
488
43.263
−35.252
22.169
1.00
57.42
A
O


ATOM
7544
C
GLU
A
488
43.990
−31.653
19.039
1.00
30.86
A
C


ATOM
7545
O
GLU
A
488
44.406
−32.077
17.959
1.00
30.25
A
O


ATOM
7547
N
SER
A
489
42.742
−31.226
19.216
1.00
28.77
A
N


ATOM
7548
CA
SER
A
489
41.759
−31.338
18.153
1.00
29.03
A
C


ATOM
7550
CB
SER
A
489
40.361
−31.004
18.646
1.00
28.33
A
C


ATOM
7553
OG
SER
A
489
40.002
−31.853
19.725
1.00
37.93
A
O


ATOM
7555
C
SER
A
489
42.124
−30.416
17.000
1.00
28.35
A
C


ATOM
7556
O
SER
A
489
41.905
−30.761
15.842
1.00
29.09
A
O


ATOM
7558
N
VAL
A
490
42.683
−29.257
17.327
1.00
27.58
A
N


ATOM
7559
CA
VAL
A
490
43.156
−28.332
16.308
1.00
27.37
A
C


ATOM
7561
CB
VAL
A
490
43.492
−26.971
16.899
1.00
27.54
A
C


ATOM
7563
CG1
VAL
A
490
44.224
−26.084
15.887
1.00
23.38
A
C


ATOM
7567
CG2
VAL
A
490
42.186
−26.322
17.351
1.00
26.23
A
C


ATOM
7571
C
VAL
A
490
44.308
−28.940
15.538
1.00
27.62
A
C


ATOM
7572
O
VAL
A
490
44.316
−28.869
14.319
1.00
28.81
A
O


ATOM
7574
N
MET
A
491
45.242
−29.589
16.225
1.00
29.11
A
N


ATOM
7575
CA
MET
A
491
46.328
−30.317
15.530
1.00
28.74
A
C


ATOM
7577
CB
MET
A
491
47.254
−31.019
16.529
1.00
32.05
A
C


ATOM
7580
CG
MET
A
491
48.053
−30.105
17.437
1.00
34.71
A
C


ATOM
7583
SD
MET
A
491
49.345
−29.289
16.533
1.00
54.88
A
S


ATOM
7584
CE
MET
A
491
50.240
−28.583
17.932
1.00
61.26
A
C


ATOM
7588
C
MET
A
491
45.764
−31.376
14.592
1.00
27.27
A
C


ATOM
7589
O
MET
A
491
46.251
−31.544
13.480
1.00
29.18
A
O


ATOM
7591
N
ASN
A
492
44.742
−32.102
15.042
1.00
24.90
A
N


ATOM
7592
CA
ASN
A
492
44.112
−33.108
14.194
1.00
24.42
A
C


ATOM
7594
CB
ASN
A
492
43.117
−33.973
14.976
1.00
27.09
A
C


ATOM
7597
CG
ASN
A
492
43.790
−34.834
16.076
1.00
32.10
A
C


ATOM
7598
OD1
ASN
A
492
45.011
−35.022
16.111
1.00
36.38
A
O


ATOM
7599
ND2
ASN
A
492
42.971
−35.342
16.983
1.00
29.67
A
N


ATOM
7602
C
ASN
A
492
43.416
−32.509
12.971
1.00
21.31
A
C


ATOM
7603
O
ASN
A
492
43.365
−33.141
11.924
1.00
19.60
A
O


ATOM
7605
N
LEU
A
493
42.864
−31.312
13.119
1.00
19.85
A
N


ATOM
7606
CA
LEU
A
493
42.208
−30.609
12.026
1.00
21.49
A
C


ATOM
7608
CB
LEU
A
493
41.438
−29.402
12.570
1.00
22.55
A
C


ATOM
7611
CG
LEU
A
493
40.562
−28.537
11.637
1.00
30.39
A
C


ATOM
7613
CD1
LEU
A
493
39.640
−29.355
10.718
1.00
30.23
A
C


ATOM
7617
CD2
LEU
A
493
39.693
−27.559
12.479
1.00
23.06
A
C


ATOM
7621
C
LEU
A
493
43.253
−30.196
10.988
1.00
20.61
A
C


ATOM
7622
O
LEU
A
493
43.024
−30.298
9.781
1.00
21.55
A
O


ATOM
7624
N
ILE
A
494
44.427
−29.800
11.463
1.00
19.95
A
N


ATOM
7625
CA
ILE
A
494
45.529
−29.519
10.574
1.00
21.52
A
C


ATOM
7627
CB
ILE
A
494
46.739
−28.978
11.329
1.00
20.44
A
C


ATOM
7629
CG1
ILE
A
494
46.492
−27.511
11.724
1.00
22.83
A
C


ATOM
7632
CD1
ILE
A
494
47.454
−27.023
12.815
1.00
19.27
A
C


ATOM
7636
CG2
ILE
A
494
47.989
−29.041
10.489
1.00
18.64
A
C


ATOM
7640
C
ILE
A
494
45.898
−30.764
9.762
1.00
22.01
A
C


ATOM
7641
O
ILE
A
494
46.021
−30.688
8.539
1.00
25.12
A
O


ATOM
7643
N
ASP
A
495
46.087
−31.885
10.437
1.00
20.80
A
N


ATOM
7644
CA
ASP
A
495
46.397
−33.138
9.773
1.00
21.60
A
C


ATOM
7646
CB
ASP
A
495
46.473
−34.281
10.791
1.00
22.75
A
C


ATOM
7649
CG
ASP
A
495
47.682
−34.161
11.731
1.00
24.78
A
C


ATOM
7650
OD1
ASP
A
495
48.662
−33.458
11.379
1.00
31.93
A
O


ATOM
7651
OD2
ASP
A
495
47.641
−34.762
12.831
1.00
35.25
A
O


ATOM
7652
C
ASP
A
495
45.346
−33.462
8.740
1.00
22.09
A
C


ATOM
7653
O
ASP
A
495
45.666
−33.770
7.596
1.00
22.13
A
O


ATOM
7655
N
GLU
A
496
44.087
−33.342
9.134
1.00
23.17
A
N


ATOM
7656
CA
GLU
A
496
42.972
−33.693
8.258
1.00
25.14
A
C


ATOM
7658
CB
GLU
A
496
41.643
−33.501
8.984
1.00
26.79
A
C


ATOM
7661
CG
GLU
A
496
40.397
−33.761
8.177
1.00
35.71
A
C


ATOM
7664
CD
GLU
A
496
39.117
−33.280
8.886
1.00
44.71
A
C


ATOM
7665
OE1
GLU
A
496
38.810
−33.788
9.987
1.00
47.95
A
O


ATOM
7666
OE2
GLU
A
496
38.416
−32.402
8.328
1.00
50.58
A
O


ATOM
7667
C
GLU
A
496
43.032
−32.834
7.024
1.00
24.17
A
C


ATOM
7668
O
GLU
A
496
42.890
−33.344
5.909
1.00
23.57
A
O


ATOM
7670
N
THR
A
497
43.271
−31.535
7.232
1.00
23.07
A
N


ATOM
7671
CA
THR
A
497
43.327
−30.575
6.143
1.00
21.41
A
C


ATOM
7673
CB
THR
A
497
43.465
−29.157
6.674
1.00
22.58
A
C


ATOM
7675
OG1
THR
A
497
42.381
−28.887
7.575
1.00
25.05
A
O


ATOM
7677
CG2
THR
A
497
43.436
−28.162
5.551
1.00
17.59
A
C


ATOM
7681
C
THR
A
497
44.481
−30.901
5.175
1.00
22.39
A
C


ATOM
7682
O
THR
A
497
44.304
−30.840
3.961
1.00
20.87
A
O


ATOM
7684
N
TRP
A
498
45.641
−31.275
5.718
1.00
20.20
A
N


ATOM
7685
CA
TRP
A
498
46.743
−31.748
4.888
1.00
21.37
A
C


ATOM
7687
CB
TRP
A
498
47.973
−32.065
5.760
1.00
18.97
A
C


ATOM
7690
CG
TRP
A
498
48.874
−30.887
5.894
1.00
21.52
A
C


ATOM
7691
CD1
TRP
A
498
48.969
−30.038
6.953
1.00
13.13
A
C


ATOM
7693
NE1
TRP
A
498
49.885
−29.084
6.704
1.00
21.91
A
N


ATOM
7695
CE2
TRP
A
498
50.399
−29.277
5.454
1.00
19.92
A
C


ATOM
7696
CD2
TRP
A
498
49.780
−30.409
4.920
1.00
17.93
A
C


ATOM
7697
CE3
TRP
A
498
50.135
−30.832
3.646
1.00
23.82
A
C


ATOM
7699
CZ3
TRP
A
498
51.097
−30.125
2.961
1.00
24.54
A
C


ATOM
7701
CH2
TRP
A
498
51.705
−29.007
3.526
1.00
25.21
A
C


ATOM
7703
CZ2
TRP
A
498
51.375
−28.572
4.775
1.00
24.04
A
C


ATOM
7705
C
TRP
A
498
46.387
−32.963
4.013
1.00
19.42
A
C


ATOM
7706
O
TRP
A
498
46.715
−33.008
2.836
1.00
20.26
A
O


ATOM
7708
N
LYS
A
499
45.727
−33.944
4.588
1.00
19.66
A
N


ATOM
7709
CA
LYS
A
499
45.320
−35.113
3.824
1.00
21.18
A
C


ATOM
7711
CB
LYS
A
499
44.554
−36.105
4.701
1.00
20.73
A
C


ATOM
7714
CG
LYS
A
499
45.406
−36.825
5.766
1.00
20.29
A
C


ATOM
7717
CD
LYS
A
499
44.547
−37.888
6.525
1.00
21.48
A
C


ATOM
7720
CE
LYS
A
499
45.126
−38.323
7.841
1.00
21.99
A
C


ATOM
7723
NZ
LYS
A
499
44.166
−39.231
8.565
1.00
24.95
A
N


ATOM
7727
C
LYS
A
499
44.451
−34.701
2.655
1.00
20.41
A
C


ATOM
7728
O
LYS
A
499
44.532
−35.278
1.598
1.00
23.27
A
O


ATOM
7730
N
LYS
A
500
43.628
−33.688
2.842
1.00
20.82
A
N


ATOM
7731
CA
LYS
A
500
42.761
−33.233
1.779
1.00
23.10
A
C


ATOM
7733
CB
LYS
A
500
41.613
−32.392
2.351
1.00
24.87
A
C


ATOM
7736
CG
LYS
A
500
40.575
−33.199
3.110
1.00
24.42
A
C


ATOM
7739
CD
LYS
A
500
39.505
−32.282
3.741
1.00
34.06
A
C


ATOM
7742
CE
LYS
A
500
38.487
−33.073
4.598
1.00
33.59
A
C


ATOM
7745
NZ
LYS
A
500
37.318
−32.261
5.058
1.00
39.36
A
N


ATOM
7749
C
LYS
A
500
43.529
−32.461
0.703
1.00
22.13
A
C


ATOM
7750
O
LYS
A
500
43.233
−32.586
−0.469
1.00
23.08
A
O


ATOM
7752
N
MET
A
501
44.516
−31.665
1.088
1.00
22.16
A
N


ATOM
7753
CA
MET
A
501
45.324
−30.960
0.101
1.00
19.81
A
C


ATOM
7755
CB
MET
A
501
46.228
−29.944
0.770
1.00
19.32
A
C


ATOM
7758
CG
MET
A
501
45.516
−28.822
1.490
1.00
21.43
A
C


ATOM
7761
SD
MET
A
501
46.681
−27.490
1.974
1.00
27.05
A
S


ATOM
7762
CE
MET
A
501
47.856
−28.310
3.053
1.00
23.38
A
C


ATOM
7766
C
MET
A
501
46.176
−31.946
−0.698
1.00
18.61
A
C


ATOM
7767
O
MET
A
501
46.410
−31.758
−1.888
1.00
18.54
A
O


ATOM
7769
N
ASN
A
502
46.658
−32.991
−0.037
1.00
19.21
A
N


ATOM
7770
CA
ASN
A
502
47.440
−34.013
−0.717
1.00
18.62
A
C


ATOM
7772
CB
ASN
A
502
47.922
−35.069
0.277
1.00
18.18
A
C


ATOM
7775
CG
ASN
A
502
48.980
−34.544
1.216
1.00
20.41
A
C


ATOM
7776
OD1
ASN
A
502
49.635
−33.522
0.933
1.00
20.85
A
O


ATOM
7777
ND2
ASN
A
502
49.167
−35.244
2.353
1.00
14.88
A
N


ATOM
7780
C
ASN
A
502
46.629
−34.674
−1.815
1.00
20.92
A
C


ATOM
7781
O
ASN
A
502
47.140
−34.963
−2.889
1.00
21.10
A
O


ATOM
7783
N
LYS
A
503
45.361
−34.902
−1.548
1.00
21.59
A
N


ATOM
7784
CA
LYS
A
503
44.492
−35.487
−2.543
1.00
26.84
A
C


ATOM
7786
CB
LYS
A
503
43.158
−35.894
−1.907
1.00
25.07
A
C


ATOM
7789
CG
LYS
A
503
42.272
−36.688
−2.832
1.00
31.50
A
C


ATOM
7792
CD
LYS
A
503
41.048
−37.279
−2.122
1.00
37.63
A
C


ATOM
7795
CE
LYS
A
503
40.180
−38.027
−3.135
1.00
42.50
A
C


ATOM
7798
NZ
LYS
A
503
38.799
−38.319
−2.637
1.00
39.80
A
N


ATOM
7802
C
LYS
A
503
44.265
−34.554
−3.751
1.00
26.24
A
C


ATOM
7803
O
LYS
A
503
44.388
−34.969
−4.896
1.00
24.15
A
O


ATOM
7805
N
GLU
A
504
43.937
−33.301
−3.477
1.00
28.57
A
N


ATOM
7806
CA
GLU
A
504
43.681
−32.298
−4.520
1.00
28.52
A
C


ATOM
7808
CB
GLU
A
504
43.343
−30.946
−3.865
1.00
30.61
A
C


ATOM
7811
CG
GLU
A
504
42.958
−29.790
−4.821
1.00
38.94
A
C


ATOM
7814
CD
GLU
A
504
41.566
−29.921
−5.427
1.00
46.58
A
C


ATOM
7815
OE1
GLU
A
504
41.310
−29.262
−6.453
1.00
52.18
A
O


ATOM
7816
OE2
GLU
A
504
40.723
−30.683
−4.896
1.00
53.41
A
O


ATOM
7817
C
GLU
A
504
44.920
−32.185
−5.412
1.00
27.76
A
C


ATOM
7818
O
GLU
A
504
44.814
−32.059
−6.628
1.00
26.82
A
O


ATOM
7820
N
LYS
A
505
46.101
−32.268
−4.805
1.00
25.80
A
N


ATOM
7821
CA
LYS
A
505
47.338
−32.166
−5.559
1.00
26.51
A
C


ATOM
7823
CB
LYS
A
505
48.533
−32.046
−4.617
1.00
23.37
A
C


ATOM
7826
CG
LYS
A
505
49.916
−32.048
−5.295
1.00
23.18
A
C


ATOM
7829
CD
LYS
A
505
50.165
−30.869
−6.209
1.00
27.18
A
C


ATOM
7832
CE
LYS
A
505
51.471
−31.033
−7.011
1.00
21.66
A
C


ATOM
7835
NZ
LYS
A
505
52.684
−30.936
−6.205
1.00
31.62
A
N


ATOM
7839
C
LYS
A
505
47.531
−33.360
−6.491
1.00
28.51
A
C


ATOM
7840
O
LYS
A
505
48.058
−33.230
−7.598
1.00
28.28
A
O


ATOM
7842
N
LEU
A
506
47.137
−34.520
−6.011
1.00
31.86
A
N


ATOM
7843
CA
LEU
A
506
47.448
−35.765
−6.663
1.00
36.04
A
C


ATOM
7845
CB
LEU
A
506
47.288
−36.918
−5.682
1.00
37.63
A
C


ATOM
7848
CG
LEU
A
506
48.038
−38.207
−5.980
1.00
42.29
A
C


ATOM
7850
CD1
LEU
A
506
49.507
−37.926
−6.154
1.00
35.85
A
C


ATOM
7854
CD2
LEU
A
506
47.800
−39.204
−4.820
1.00
46.05
A
C


ATOM
7858
C
LEU
A
506
46.558
−35.972
−7.872
1.00
37.67
A
C


ATOM
7859
O
LEU
A
506
47.003
−36.495
−8.875
1.00
38.71
A
O


ATOM
7861
N
GLY
A
507
45.309
−35.552
−7.797
1.00
39.52
A
N


ATOM
7862
CA
GLY
A
507
44.443
−35.753
−8.922
1.00
43.92
A
C


ATOM
7865
C
GLY
A
507
43.260
−34.842
−8.940
1.00
46.84
A
C


ATOM
7866
O
GLY
A
507
42.912
−34.221
−7.932
1.00
49.96
A
O


ATOM
7868
N
GLY
A
508
42.676
−34.743
−10.122
1.00
49.06
A
N


ATOM
7869
CA
GLY
A
508
41.363
−34.150
−10.302
1.00
50.99
A
C


ATOM
7872
C
GLY
A
508
41.194
−32.736
−9.777
1.00
50.71
A
C


ATOM
7873
O
GLY
A
508
40.122
−32.409
−9.241
1.00
52.36
A
O


ATOM
7875
N
SER
A
509
42.203
−31.880
−9.918
1.00
47.13
A
N


ATOM
7876
CA
SER
A
509
41.952
−30.484
−9.528
1.00
47.06
A
C


ATOM
7878
CB
SER
A
509
43.191
−29.736
−8.981
1.00
45.68
A
C


ATOM
7881
OG
SER
A
509
42.806
−28.477
−8.381
1.00
42.36
A
O


ATOM
7883
C
SER
A
509
41.382
−29.749
−10.715
1.00
44.82
A
C


ATOM
7884
O
SER
A
509
41.689
−30.070
−11.852
1.00
42.86
A
O


ATOM
7886
N
LEU
A
510
40.554
−28.756
−10.416
1.00
45.06
A
N


ATOM
7887
CA
LEU
A
510
40.113
−27.777
−11.399
1.00
45.40
A
C


ATOM
7889
CB
LEU
A
510
38.958
−26.930
−10.832
1.00
47.41
A
C


ATOM
7892
CG
LEU
A
510
37.786
−27.690
−10.165
1.00
55.26
A
C


ATOM
7894
CD1
LEU
A
510
36.624
−26.741
−9.788
1.00
57.58
A
C


ATOM
7898
CD2
LEU
A
510
37.270
−28.882
−11.042
1.00
61.12
A
C


ATOM
7902
C
LEU
A
510
41.286
−26.872
−11.801
1.00
42.51
A
C


ATOM
7903
O
LEU
A
510
41.294
−26.326
−12.901
1.00
44.42
A
O


ATOM
7905
N
PHE
A
511
42.267
−26.730
−10.908
1.00
37.23
A
N


ATOM
7906
CA
PHE
A
511
43.472
−25.953
−11.166
1.00
34.84
A
C


ATOM
7908
CB
PHE
A
511
43.886
−25.210
−9.902
1.00
34.34
A
C


ATOM
7911
CG
PHE
A
511
42.953
−24.144
−9.522
1.00
28.92
A
C


ATOM
7912
CD1
PHE
A
511
43.120
−22.857
−10.008
1.00
29.05
A
C


ATOM
7914
CE1
PHE
A
511
42.239
−21.868
−9.667
1.00
31.91
A
C


ATOM
7916
CZ
PHE
A
511
41.166
−22.149
−8.835
1.00
34.31
A
C


ATOM
7918
CE2
PHE
A
511
40.987
−23.436
−8.353
1.00
31.94
A
C


ATOM
7920
CD2
PHE
A
511
41.879
−24.420
−8.705
1.00
28.15
A
C


ATOM
7922
C
PHE
A
511
44.646
−26.806
−11.627
1.00
33.67
A
C


ATOM
7923
O
PHE
A
511
44.729
−27.979
−11.330
1.00
32.95
A
O


ATOM
7925
N
ALA
A
512
45.581
−26.186
−12.334
1.00
35.25
A
N


ATOM
7926
CA
ALA
A
512
46.800
−26.873
−12.750
1.00
35.70
A
C


ATOM
7928
CB
ALA
A
512
47.539
−26.051
−13.813
1.00
34.66
A
C


ATOM
7932
C
ALA
A
512
47.707
−27.148
−11.529
1.00
36.10
A
C


ATOM
7933
O
ALA
A
512
47.699
−26.406
−10.547
1.00
36.63
A
O


ATOM
7935
N
LYS
A
513
48.475
−28.225
−11.603
1.00
36.02
A
N


ATOM
7936
CA
LYS
A
513
49.284
−28.673
−10.484
1.00
37.34
A
C


ATOM
7938
CB
LYS
A
513
50.063
−29.942
−10.849
1.00
37.46
A
C


ATOM
7941
CG
LYS
A
513
49.162
−31.182
−10.883
1.00
43.80
A
C


ATOM
7944
CD
LYS
A
513
49.963
−32.482
−10.925
1.00
50.12
A
C


ATOM
7947
CE
LYS
A
513
49.023
−33.696
−10.922
1.00
56.16
A
C


ATOM
7950
NZ
LYS
A
513
49.717
−34.969
−10.585
1.00
55.05
A
N


ATOM
7954
C
LYS
A
513
50.214
−27.622
−9.884
1.00
35.55
A
C


ATOM
7955
O
LYS
A
513
50.337
−27.571
−8.679
1.00
34.97
A
O


ATOM
7957
N
PRO
A
514
50.850
−26.775
−10.715
1.00
33.86
A
N


ATOM
7958
CA
PRO
A
514
51.776
−25.809
−10.137
1.00
30.23
A
C


ATOM
7960
CB
PRO
A
514
52.402
−25.116
−11.359
1.00
30.51
A
C


ATOM
7963
CG
PRO
A
514
52.125
−26.036
−12.529
1.00
34.84
A
C


ATOM
7966
CD
PRO
A
514
50.855
−26.753
−12.197
1.00
35.73
A
C


ATOM
7969
C
PRO
A
514
51.082
−24.796
−9.233
1.00
27.77
A
C


ATOM
7970
O
PRO
A
514
51.627
−24.406
−8.205
1.00
30.05
A
O


ATOM
7971
N
PHE
A
515
49.886
−24.373
−9.587
1.00
25.77
A
N


ATOM
7972
CA
PHE
A
515
49.195
−23.428
−8.732
1.00
24.83
A
C


ATOM
7974
CB
PHE
A
515
48.074
−22.699
−9.462
1.00
23.92
A
C


ATOM
7977
CG
PHE
A
515
47.262
−21.818
−8.557
1.00
26.15
A
C


ATOM
7978
CD1
PHE
A
515
47.779
−20.626
−8.087
1.00
25.26
A
C


ATOM
7980
CE1
PHE
A
515
47.041
−19.832
−7.203
1.00
25.88
A
C


ATOM
7982
CZ
PHE
A
515
45.780
−20.227
−6.804
1.00
22.17
A
C


ATOM
7984
CE2
PHE
A
515
45.266
−21.432
−7.253
1.00
23.27
A
C


ATOM
7986
CD2
PHE
A
515
46.011
−22.225
−8.108
1.00
26.63
A
C


ATOM
7988
C
PHE
A
515
48.675
−24.143
−7.460
1.00
24.34
A
C


ATOM
7989
O
PHE
A
515
48.794
−23.599
−6.371
1.00
23.33
A
O


ATOM
7991
N
VAL
A
516
48.156
−25.369
−7.588
1.00
22.98
A
N


ATOM
7992
CA
VAL
A
516
47.815
−26.159
−6.401
1.00
22.66
A
C


ATOM
7994
CB
VAL
A
516
47.387
−27.605
−6.706
1.00
24.87
A
C


ATOM
7996
CG1
VAL
A
516
46.149
−27.671
−7.666
1.00
22.01
A
C


ATOM
8000
CG2
VAL
A
516
47.109
−28.387
−5.377
1.00
17.25
A
C


ATOM
8004
C
VAL
A
516
49.022
−26.187
−5.432
1.00
22.26
A
C


ATOM
8005
O
VAL
A
516
48.861
−25.964
−4.228
1.00
21.22
A
O


ATOM
8007
N
GLU
A
517
50.213
−26.411
−5.976
1.00
21.70
A
N


ATOM
8008
CA
GLU
A
517
51.456
−26.510
−5.188
1.00
22.29
A
C


ATOM
8010
CB
GLU
A
517
52.584
−27.047
−6.072
1.00
22.50
A
C


ATOM
8013
CG
GLU
A
517
53.939
−27.283
−5.376
1.00
19.35
A
C


ATOM
8016
CD
GLU
A
517
53.941
−28.451
−4.347
1.00
27.61
A
C


ATOM
8017
OE1
GLU
A
517
52.962
−29.218
−4.228
1.00
23.47
A
O


ATOM
8018
OE2
GLU
A
517
54.940
−28.605
−3.631
1.00
30.16
A
O


ATOM
8019
C
GLU
A
517
51.847
−25.157
−4.576
1.00
22.35
A
C


ATOM
8020
O
GLU
A
517
52.253
−25.096
−3.404
1.00
26.83
A
O


ATOM
8022
N
THR
A
518
51.709
−24.082
−5.354
1.00
21.58
A
N


ATOM
8023
CA
THR
A
518
51.902
−22.731
−4.836
1.00
24.40
A
C


ATOM
8025
CB
THR
A
518
51.689
−21.634
−5.925
1.00
26.67
A
C


ATOM
8027
OG1
THR
A
518
52.642
−21.808
−6.973
1.00
23.81
A
O


ATOM
8029
CG2
THR
A
518
51.876
−20.228
−5.351
1.00
24.26
A
C


ATOM
8033
C
THR
A
518
50.969
−22.518
−3.644
1.00
25.98
A
C


ATOM
8034
O
THR
A
518
51.400
−22.003
−2.596
1.00
25.54
A
O


ATOM
8036
N
ALA
A
519
49.717
−22.968
−3.774
1.00
23.55
A
N


ATOM
8037
CA
ALA
A
519
48.772
−22.859
−2.676
1.00
23.19
A
C


ATOM
8039
CB
ALA
A
519
47.375
−23.219
−3.096
1.00
20.70
A
C


ATOM
8043
C
ALA
A
519
49.182
−23.644
−1.436
1.00
23.29
A
C


ATOM
8044
O
ALA
A
519
49.096
−23.125
−0.286
1.00
24.26
A
O


ATOM
8046
N
ILE
A
520
49.673
−24.853
−1.639
1.00
21.17
A
N


ATOM
8047
CA
ILE
A
520
50.097
−25.677
−0.500
1.00
19.87
A
C


ATOM
8049
CB
ILE
A
520
50.425
−27.126
−0.957
1.00
20.77
A
C


ATOM
8051
CG1
ILE
A
520
49.146
−27.857
−1.421
1.00
20.74
A
C


ATOM
8054
CD1
ILE
A
520
49.421
−29.223
−2.184
1.00
19.45
A
C


ATOM
8058
CG2
ILE
A
520
51.083
−27.909
0.152
1.00
16.11
A
C


ATOM
8062
C
ILE
A
520
51.288
−25.003
0.202
1.00
20.17
A
C


ATOM
8063
O
ILE
A
520
51.384
−25.018
1.437
1.00
19.37
A
O


ATOM
8065
N
ASN
A
521
52.166
−24.366
−0.574
1.00
21.54
A
N


ATOM
8066
CA
ASN
A
521
53.299
−23.620
0.014
1.00
20.54
A
C


ATOM
8068
CB
ASN
A
521
54.188
−22.992
−1.066
1.00
21.56
A
C


ATOM
8071
CG
ASN
A
521
54.966
−24.024
−1.867
1.00
24.44
A
C


ATOM
8072
OD1
ASN
A
521
55.198
−25.124
−1.399
1.00
19.38
A
O


ATOM
8073
ND2
ASN
A
521
55.365
−23.666
−3.084
1.00
18.91
A
N


ATOM
8076
C
ASN
A
521
52.892
−22.559
1.017
1.00
19.40
A
C


ATOM
8077
O
ASN
A
521
53.621
−22.274
1.946
1.00
20.79
A
O


ATOM
8079
N
LEU
A
522
51.724
−21.961
0.870
1.00
22.97
A
N


ATOM
8080
CA
LEU
A
522
51.287
−21.020
1.894
1.00
22.18
A
C


ATOM
8082
CB
LEU
A
522
49.999
−20.375
1.480
1.00
21.54
A
C


ATOM
8085
CG
LEU
A
522
49.371
−19.451
2.528
1.00
28.84
A
C


ATOM
8087
CD1
LEU
A
522
49.451
−18.040
2.067
1.00
28.12
A
C


ATOM
8091
CD2
LEU
A
522
47.923
−19.860
2.764
1.00
22.93
A
C


ATOM
8095
C
LEU
A
522
51.128
−21.739
3.258
1.00
23.98
A
C


ATOM
8096
O
LEU
A
522
51.440
−21.191
4.335
1.00
27.60
A
O


ATOM
8098
N
ALA
A
523
50.655
−22.966
3.219
1.00
20.93
A
N


ATOM
8099
CA
ALA
A
523
50.483
−23.745
4.435
1.00
20.65
A
C


ATOM
8101
CB
ALA
A
523
49.688
−25.053
4.123
1.00
18.52
A
C


ATOM
8105
C
ALA
A
523
51.858
−24.069
5.025
1.00
19.62
A
C


ATOM
8106
O
ALA
A
523
52.066
−23.988
6.225
1.00
19.29
A
O


ATOM
8108
N
ARG
A
524
52.790
−24.453
4.158
1.00
21.30
A
N


ATOM
8109
CA
ARG
A
524
54.160
−24.730
4.566
1.00
19.62
A
C


ATOM
8111
CB
ARG
A
524
54.994
−25.155
3.355
1.00
19.24
A
C


ATOM
8114
CG
ARG
A
524
54.604
−26.493
2.752
1.00
20.08
A
C


ATOM
8117
CD
ARG
A
524
55.572
−26.973
1.663
1.00
16.22
A
C


ATOM
8120
NE
ARG
A
524
55.254
−28.341
1.267
1.00
17.63
A
N


ATOM
8122
CZ
ARG
A
524
54.851
−28.736
0.065
1.00
22.37
A
C


ATOM
8123
NH1
ARG
A
524
54.705
−27.877
−0.917
1.00
22.88
A
N


ATOM
8126
NH2
ARG
A
524
54.577
−30.020
−0.153
1.00
22.48
A
N


ATOM
8129
C
ARG
A
524
54.783
−23.497
5.211
1.00
18.86
A
C


ATOM
8130
O
ARG
A
524
55.416
−23.587
6.243
1.00
20.03
A
O


ATOM
8132
N
GLN
A
525
54.627
−22.344
4.577
1.00
21.45
A
N


ATOM
8133
CA
GLN
A
525
55.227
−21.127
5.095
1.00
23.44
A
C


ATOM
8135
CB
GLN
A
525
55.050
−19.940
4.126
1.00
24.10
A
C


ATOM
8138
CG
GLN
A
525
55.702
−18.631
4.655
1.00
27.82
A
C


ATOM
8141
CD
GLN
A
525
57.200
−18.783
4.854
1.00
31.75
A
C


ATOM
8142
OE1
GLN
A
525
57.858
−19.483
4.107
1.00
35.59
A
O


ATOM
8143
NE2
GLN
A
525
57.741
−18.116
5.854
1.00
35.48
A
N


ATOM
8146
C
GLN
A
525
54.618
−20.823
6.442
1.00
21.93
A
C


ATOM
8147
O
GLN
A
525
55.301
−20.367
7.349
1.00
24.82
A
O


ATOM
8149
N
SER
A
526
53.335
−21.125
6.588
1.00
23.48
A
N


ATOM
8150
CA
SER
A
526
52.645
−20.951
7.865
1.00
21.99
A
C


ATOM
8152
CB
SER
A
526
51.157
−21.240
7.721
1.00
21.77
A
C


ATOM
8155
OG
SER
A
526
50.545
−20.385
6.756
1.00
27.32
A
O


ATOM
8157
C
SER
A
526
53.245
−21.829
8.945
1.00
24.68
A
C


ATOM
8158
O
SER
A
526
53.518
−21.362
10.061
1.00
24.00
A
O


ATOM
8160
N
HIS
A
527
53.480
−23.096
8.630
1.00
24.99
A
N


ATOM
8161
CA
HIS
A
527
54.171
−23.962
9.610
1.00
28.16
A
C


ATOM
8163
CB
HIS
A
527
54.357
−25.381
9.073
1.00
29.27
A
C


ATOM
8166
CG
HIS
A
527
53.101
−26.172
9.090
1.00
25.87
A
C


ATOM
8167
ND1
HIS
A
527
52.548
−26.642
10.258
1.00
26.45
A
N


ATOM
8169
CE1
HIS
A
527
51.424
−27.278
9.982
1.00
25.98
A
C


ATOM
8171
NE2
HIS
A
527
51.211
−27.201
8.681
1.00
24.15
A
N


ATOM
8173
CD2
HIS
A
527
52.241
−26.501
8.102
1.00
26.74
A
C


ATOM
8175
C
HIS
A
527
55.523
−23.428
10.010
1.00
28.59
A
C


ATOM
8176
O
HIS
A
527
55.911
−23.545
11.155
1.00
29.28
A
O


ATOM
8178
N
CYS
A
528
56.233
−22.863
9.042
1.00
29.41
A
N


ATOM
8179
CA
CYS
A
528
57.620
−22.452
9.236
1.00
32.72
A
C


ATOM
8181
CB
CYS
A
528
58.325
−22.320
7.884
1.00
30.69
A
C


ATOM
8184
SG
CYS
A
528
58.709
−23.947
7.199
1.00
30.00
A
S


ATOM
8186
C
CYS
A
528
57.731
−21.150
10.027
1.00
35.27
A
C


ATOM
8187
O
CYS
A
528
58.642
−20.983
10.799
1.00
35.65
A
O


ATOM
8189
N
THR
A
529
56.784
−20.249
9.814
1.00
39.06
A
N


ATOM
8190
CA
THR
A
529
56.751
−18.951
10.470
1.00
40.10
A
C


ATOM
8192
CB
THR
A
529
55.848
−18.006
9.689
1.00
40.17
A
C


ATOM
8194
OG1
THR
A
529
56.529
−17.624
8.491
1.00
38.25
A
O


ATOM
8196
CG2
THR
A
529
55.488
−16.770
10.521
1.00
39.82
A
C


ATOM
8200
C
THR
A
529
56.265
−19.016
11.911
1.00
42.32
A
C


ATOM
8201
O
THR
A
529
56.803
−18.308
12.775
1.00
43.34
A
O


ATOM
8203
N
TYR
A
530
55.263
−19.854
12.173
1.00
44.35
A
N


ATOM
8204
CA
TYR
A
530
54.693
−19.966
13.505
1.00
46.00
A
C


ATOM
8206
CB
TYR
A
530
53.166
−20.032
13.439
1.00
44.27
A
C


ATOM
8209
CG
TYR
A
530
52.609
−18.762
12.860
1.00
37.30
A
C


ATOM
8210
CD1
TYR
A
530
52.537
−17.608
13.623
1.00
41.32
A
C


ATOM
8212
CE1
TYR
A
530
52.068
−16.421
13.084
1.00
36.85
A
C


ATOM
8214
CZ
TYR
A
530
51.680
−16.379
11.772
1.00
34.37
A
C


ATOM
8215
OH
TYR
A
530
51.224
−15.203
11.239
1.00
42.34
A
O


ATOM
8217
CE2
TYR
A
530
51.754
−17.510
10.987
1.00
37.02
A
C


ATOM
8219
CD2
TYR
A
530
52.225
−18.687
11.535
1.00
33.51
A
C


ATOM
8221
C
TYR
A
530
55.343
−21.106
14.288
1.00
51.39
A
C


ATOM
8222
O
TYR
A
530
54.775
−22.175
14.481
1.00
52.31
A
O


ATOM
8224
N
HIS
A
531
56.561
−20.811
14.740
1.00
58.00
A
N


ATOM
8225
CA
HIS
A
531
57.399
−21.680
15.572
1.00
61.94
A
C


ATOM
8227
CB
HIS
A
531
58.753
−21.900
14.875
1.00
62.85
A
C


ATOM
8230
CG
HIS
A
531
59.575
−20.646
14.738
1.00
65.82
A
C


ATOM
8231
ND1
HIS
A
531
59.608
−19.895
13.579
1.00
70.80
A
N


ATOM
8233
CE1
HIS
A
531
60.404
−18.852
13.752
1.00
66.74
A
C


ATOM
8235
NE2
HIS
A
531
60.883
−18.894
14.982
1.00
63.48
A
N


ATOM
8237
CD2
HIS
A
531
60.381
−20.004
15.620
1.00
65.00
A
C


ATOM
8239
C
HIS
A
531
57.655
−20.986
16.920
1.00
64.85
A
C


ATOM
8240
O
HIS
A
531
57.504
−19.758
17.030
1.00
64.46
A
O


ATOM
8242
N
ASN
A
532
58.067
−21.766
17.926
1.00
67.27
A
N


ATOM
8243
CA
ASN
A
532
58.496
−21.224
19.224
1.00
68.94
A
C


ATOM
8245
CB
ASN
A
532
57.603
−21.755
20.366
1.00
70.24
A
C


ATOM
8248
CG
ASN
A
532
56.240
−21.039
20.445
1.00
75.92
A
C


ATOM
8249
OD1
ASN
A
532
55.500
−20.950
19.452
1.00
78.73
A
O


ATOM
8250
ND2
ASN
A
532
55.906
−20.536
21.638
1.00
74.91
A
N


ATOM
8253
C
ASN
A
532
59.981
−21.534
19.481
1.00
68.89
A
C


ATOM
8254
O
ASN
A
532
60.352
−22.156
20.484
1.00
68.53
A
O


ATOM
8256
N
THR
A
537
67.332
−21.795
21.607
1.00
92.68
A
N


ATOM
8257
CA
THR
A
537
66.924
−20.612
20.853
1.00
93.30
A
C


ATOM
8259
CB
THR
A
537
66.958
−20.873
19.320
1.00
93.55
A
C


ATOM
8261
OG1
THR
A
537
68.054
−21.736
18.994
1.00
94.33
A
O


ATOM
8263
CG2
THR
A
537
67.102
−19.564
18.539
1.00
93.26
A
C


ATOM
8267
C
THR
A
537
65.513
−20.160
21.260
1.00
93.42
A
C


ATOM
8268
O
THR
A
537
64.724
−20.952
21.790
1.00
93.83
A
O


ATOM
8270
N
SER
A
538
65.215
−18.883
21.009
1.00
92.90
A
N


ATOM
8271
CA
SER
A
538
63.908
−18.278
21.299
1.00
92.33
A
C


ATOM
8273
CB
SER
A
538
64.113
−17.011
22.137
1.00
92.35
A
C


ATOM
8276
OG
SER
A
538
64.875
−16.046
21.429
1.00
90.48
A
O


ATOM
8278
C
SER
A
538
63.159
−17.940
19.991
1.00
91.91
A
C


ATOM
8279
O
SER
A
538
63.751
−18.023
18.918
1.00
90.87
A
O


ATOM
8281
N
PRO
A
539
61.852
−17.583
20.077
1.00
92.14
A
N


ATOM
8282
CA
PRO
A
539
61.015
−17.108
18.952
1.00
91.90
A
C


ATOM
8284
CB
PRO
A
539
59.778
−16.550
19.670
1.00
92.24
A
C


ATOM
8287
CG
PRO
A
539
59.602
−17.482
20.811
1.00
93.29
A
C


ATOM
8290
CD
PRO
A
539
61.005
−17.907
21.244
1.00
92.54
A
C


ATOM
8293
C
PRO
A
539
61.663
−16.079
17.996
1.00
90.64
A
C


ATOM
8294
O
PRO
A
539
62.570
−16.453
17.254
1.00
90.97
A
O


ATOM
8295
N
ASP
A
540
61.200
−14.823
17.973
1.00
88.91
A
N


ATOM
8296
CA
ASP
A
540
61.764
−13.832
17.045
1.00
87.34
A
C


ATOM
8298
CB
ASP
A
540
60.995
−12.501
17.090
1.00
88.16
A
C


ATOM
8301
CG
ASP
A
540
61.064
−11.734
15.767
1.00
91.26
A
C


ATOM
8302
OD1
ASP
A
540
62.082
−11.847
15.046
1.00
92.68
A
O


ATOM
8303
OD2
ASP
A
540
60.095
−11.012
15.445
1.00
92.20
A
O


ATOM
8304
C
ASP
A
540
63.249
−13.623
17.357
1.00
83.97
A
C


ATOM
8305
O
ASP
A
540
63.608
−12.904
18.291
1.00
84.17
A
O


ATOM
8307
N
GLU
A
541
64.085
−14.261
16.542
1.00
80.01
A
N


ATOM
8308
CA
GLU
A
541
65.522
−14.464
16.780
1.00
77.67
A
C


ATOM
8310
CB
GLU
A
541
65.870
−14.669
18.260
1.00
78.10
A
C


ATOM
8313
CG
GLU
A
541
67.352
−14.486
18.565
1.00
81.78
A
C


ATOM
8316
CD
GLU
A
541
67.610
−13.838
19.922
1.00
88.80
A
C


ATOM
8317
OE1
GLU
A
541
67.125
−12.702
20.144
1.00
90.81
A
O


ATOM
8318
OE2
GLU
A
541
68.306
−14.453
20.761
1.00
88.82
A
O


ATOM
8319
C
GLU
A
541
65.937
−15.699
15.973
1.00
73.57
A
C


ATOM
8320
O
GLU
A
541
66.977
−15.711
15.311
1.00
73.68
A
O


ATOM
8322
N
LEU
A
542
65.116
−16.743
16.054
1.00
68.45
A
N


ATOM
8323
CA
LEU
A
542
65.113
−17.805
15.051
1.00
64.32
A
C


ATOM
8325
CB
LEU
A
542
64.264
−18.994
15.512
1.00
64.16
A
C


ATOM
8328
CG
LEU
A
542
64.082
−20.157
14.527
1.00
66.34
A
C


ATOM
8330
CD1
LEU
A
542
63.430
−21.367
15.221
1.00
64.49
A
C


ATOM
8334
CD2
LEU
A
542
65.418
−20.547
13.870
1.00
67.67
A
C


ATOM
8338
C
LEU
A
542
64.583
−17.236
13.731
1.00
59.26
A
C


ATOM
8339
O
LEU
A
542
65.135
−17.512
12.679
1.00
56.08
A
O


ATOM
8341
N
THR
A
543
63.525
−16.431
13.807
1.00
55.75
A
N


ATOM
8342
CA
THR
A
543
63.001
−15.694
12.652
1.00
53.99
A
C


ATOM
8344
CB
THR
A
543
61.827
−14.798
13.080
1.00
52.82
A
C


ATOM
8346
OG1
THR
A
543
60.796
−15.613
13.647
1.00
55.45
A
O


ATOM
8348
CG2
THR
A
543
61.266
−13.999
11.910
1.00
47.21
A
C


ATOM
8352
C
THR
A
543
64.055
−14.811
11.984
1.00
53.90
A
C


ATOM
8353
O
THR
A
543
64.132
−14.738
10.754
1.00
53.78
A
O


ATOM
8355
N
ARG
A
544
64.861
−14.141
12.807
1.00
53.78
A
N


ATOM
8356
CA
ARG
A
544
65.880
−13.214
12.320
1.00
53.00
A
C


ATOM
8358
CB
ARG
A
544
66.482
−12.402
13.487
1.00
54.30
A
C


ATOM
8361
CG
ARG
A
544
67.763
−11.600
13.148
1.00
58.88
A
C


ATOM
8364
CD
ARG
A
544
68.416
−10.977
14.395
1.00
68.64
A
C


ATOM
8367
NE
ARG
A
544
68.769
−11.968
15.421
1.00
75.29
A
N


ATOM
8369
CZ
ARG
A
544
69.815
−12.799
15.370
1.00
78.84
A
C


ATOM
8370
NH1
ARG
A
544
70.654
−12.793
14.334
1.00
78.60
A
N


ATOM
8373
NH2
ARG
A
544
70.023
−13.656
16.367
1.00
78.30
A
N


ATOM
8376
C
ARG
A
544
66.977
−13.965
11.591
1.00
50.00
A
C


ATOM
8377
O
ARG
A
544
67.503
−13.474
10.602
1.00
49.41
A
O


ATOM
8379
N
LYS
A
545
67.342
−15.131
12.113
1.00
47.99
A
N


ATOM
8380
CA
LYS
A
545
68.378
−15.955
11.497
1.00
48.74
A
C


ATOM
8382
CB
LYS
A
545
68.824
−17.088
12.442
1.00
50.27
A
C


ATOM
8385
CG
LYS
A
545
69.814
−16.611
13.534
1.00
59.32
A
C


ATOM
8388
CD
LYS
A
545
70.549
−17.761
14.252
1.00
64.78
A
C


ATOM
8391
CE
LYS
A
545
71.708
−17.208
15.089
1.00
70.21
A
C


ATOM
8394
NZ
LYS
A
545
72.591
−18.251
15.680
1.00
71.30
A
N


ATOM
8398
C
LYS
A
545
67.892
−16.520
10.167
1.00
44.99
A
C


ATOM
8399
O
LYS
A
545
68.642
−16.585
9.194
1.00
42.74
A
O


ATOM
8401
N
ARG
A
546
66.624
−16.911
10.141
1.00
43.75
A
N


ATOM
8402
CA
ARG
A
546
66.006
−17.452
8.934
1.00
42.43
A
C


ATOM
8404
CB
ARG
A
546
64.624
−18.006
9.244
1.00
41.43
A
C


ATOM
8407
CG
ARG
A
546
64.725
−19.301
10.007
1.00
34.91
A
C


ATOM
8410
CD
ARG
A
546
63.396
−19.926
10.297
1.00
35.83
A
C


ATOM
8413
NE
ARG
A
546
63.616
−21.251
10.863
1.00
35.94
A
N


ATOM
8415
CZ
ARG
A
546
62.659
−22.099
11.220
1.00
36.20
A
C


ATOM
8416
NH1
ARG
A
546
61.380
−21.769
11.093
1.00
37.38
A
N


ATOM
8419
NH2
ARG
A
546
62.992
−23.276
11.743
1.00
39.23
A
N


ATOM
8422
C
ARG
A
546
65.963
−16.413
7.826
1.00
42.22
A
C


ATOM
8423
O
ARG
A
546
66.372
−16.706
6.704
1.00
42.78
A
O


ATOM
8425
N
VAL
A
547
65.537
−15.192
8.153
1.00
40.65
A
N


ATOM
8426
CA
VAL
A
547
65.599
−14.085
7.193
1.00
40.43
A
C


ATOM
8428
CB
VAL
A
547
65.055
−12.771
7.810
1.00
41.44
A
C


ATOM
8430
CG1
VAL
A
547
65.454
−11.568
6.974
1.00
43.77
A
C


ATOM
8434
CG2
VAL
A
547
63.543
−12.847
7.984
1.00
37.89
A
C


ATOM
8438
C
VAL
A
547
67.028
−13.846
6.715
1.00
40.76
A
C


ATOM
8439
O
VAL
A
547
67.269
−13.551
5.547
1.00
41.64
A
O


ATOM
8441
N
LEU
A
548
67.978
−13.952
7.632
1.00
39.02
A
N


ATOM
8442
CA
LEU
A
548
69.369
−13.763
7.283
1.00
37.94
A
C


ATOM
8444
CB
LEU
A
548
70.239
−13.775
8.544
1.00
38.42
A
C


ATOM
8447
CG
LEU
A
548
71.184
−12.599
8.823
1.00
45.83
A
C


ATOM
8449
CD1
LEU
A
548
70.487
−11.217
8.801
1.00
41.58
A
C


ATOM
8453
CD2
LEU
A
548
71.866
−12.861
10.179
1.00
43.53
A
C


ATOM
8457
C
LEU
A
548
69.805
−14.866
6.305
1.00
36.31
A
C


ATOM
8458
O
LEU
A
548
70.419
−14.589
5.281
1.00
37.41
A
O


ATOM
8460
N
SER
A
549
69.471
−16.115
6.607
1.00
33.80
A
N


ATOM
8461
CA
SER
A
549
69.995
−17.230
5.830
1.00
32.40
A
C


ATOM
8463
CB
SER
A
549
69.914
−18.526
6.640
1.00
32.69
A
C


ATOM
8466
OG
SER
A
549
68.573
−18.865
6.912
1.00
33.82
A
O


ATOM
8468
C
SER
A
549
69.258
−17.374
4.497
1.00
29.96
A
C


ATOM
8469
O
SER
A
549
69.816
−17.884
3.525
1.00
28.51
A
O


ATOM
8471
N
VAL
A
550
68.017
−16.896
4.444
1.00
28.34
A
N


ATOM
8472
CA
VAL
A
550
67.218
−16.982
3.232
1.00
26.12
A
C


ATOM
8474
CB
VAL
A
550
65.754
−17.231
3.551
1.00
27.43
A
C


ATOM
8476
CG1
VAL
A
550
64.912
−17.149
2.274
1.00
22.74
A
C


ATOM
8480
CG2
VAL
A
550
65.603
−18.589
4.190
1.00
20.03
A
C


ATOM
8484
C
VAL
A
550
67.352
−15.777
2.320
1.00
27.26
A
C


ATOM
8485
O
VAL
A
550
67.466
−15.933
1.101
1.00
26.44
A
O


ATOM
8487
N
ILE
A
551
67.367
−14.575
2.877
1.00
28.59
A
N


ATOM
8488
CA
ILE
A
551
67.457
−13.380
2.037
1.00
30.46
A
C


ATOM
8490
CB
ILE
A
551
66.537
−12.274
2.537
1.00
31.18
A
C


ATOM
8492
CG1
ILE
A
551
65.093
−12.747
2.553
1.00
29.53
A
C


ATOM
8495
CD1
ILE
A
551
64.570
−13.145
1.191
1.00
40.54
A
C


ATOM
8499
CG2
ILE
A
551
66.697
−11.023
1.653
1.00
29.98
A
C


ATOM
8503
C
ILE
A
551
68.841
−12.746
1.941
1.00
31.12
A
C


ATOM
8504
O
ILE
A
551
69.329
−12.460
0.843
1.00
30.57
A
O


ATOM
8506
N
THR
A
552
69.453
−12.486
3.090
1.00
33.43
A
N


ATOM
8507
CA
THR
A
552
70.551
−11.541
3.150
1.00
35.23
A
C


ATOM
8509
CB
THR
A
552
70.422
−10.661
4.419
1.00
38.85
A
C


ATOM
8511
OG1
THR
A
552
70.734
−11.431
5.583
1.00
49.74
A
O


ATOM
8513
CG2
THR
A
552
69.002
−10.115
4.567
1.00
34.09
A
C


ATOM
8517
C
THR
A
552
71.979
−12.148
3.020
1.00
35.34
A
C


ATOM
8518
O
THR
A
552
72.805
−11.623
2.259
1.00
34.57
A
O


ATOM
8520
N
GLU
A
553
72.273
−13.222
3.752
1.00
35.04
A
N


ATOM
8521
CA
GLU
A
553
73.628
−13.801
3.777
1.00
36.99
A
C


ATOM
8523
CB
GLU
A
553
74.020
−14.209
5.200
1.00
38.28
A
C


ATOM
8526
CG
GLU
A
553
74.412
−13.034
6.080
1.00
46.45
A
C


ATOM
8529
CD
GLU
A
553
75.002
−13.456
7.418
1.00
57.04
A
C


ATOM
8530
OE1
GLU
A
553
75.499
−12.564
8.142
1.00
60.01
A
O


ATOM
8531
OE2
GLU
A
553
74.972
−14.667
7.750
1.00
60.27
A
O


ATOM
8532
C
GLU
A
553
73.756
−15.027
2.879
1.00
35.15
A
C


ATOM
8533
O
GLU
A
553
73.085
−16.016
3.094
1.00
33.64
A
O


ATOM
8535
N
PRO
A
554
74.649
−14.979
1.890
1.00
35.47
A
N


ATOM
8536
CA
PRO
A
554
74.878
−16.177
1.087
1.00
33.93
A
C


ATOM
8538
CB
PRO
A
554
75.924
−15.722
0.056
1.00
35.05
A
C


ATOM
8541
CG
PRO
A
554
75.825
−14.234
0.044
1.00
35.89
A
C


ATOM
8544
CD
PRO
A
554
75.486
−13.854
1.441
1.00
36.23
A
C


ATOM
8547
C
PRO
A
554
75.426
−17.330
1.903
1.00
31.36
A
C


ATOM
8548
O
PRO
A
554
75.880
−17.153
3.018
1.00
31.42
A
O


ATOM
8549
N
ILE
A
555
75.349
−18.518
1.342
1.00
30.82
A
N


ATOM
8550
CA
ILE
A
555
75.946
−19.684
1.957
1.00
31.22
A
C


ATOM
8552
CB
ILE
A
555
75.349
−20.985
1.366
1.00
30.17
A
C


ATOM
8554
CG1
ILE
A
555
73.862
−21.095
1.715
1.00
30.75
A
C


ATOM
8557
CD1
ILE
A
555
73.166
−22.359
1.159
1.00
26.65
A
C


ATOM
8561
CG2
ILE
A
555
76.096
−22.190
1.874
1.00
29.43
A
C


ATOM
8565
C
ILE
A
555
77.455
−19.589
1.694
1.00
30.28
A
C


ATOM
8566
O
ILE
A
555
77.853
−19.201
0.607
1.00
27.19
A
O


ATOM
8568
N
LEU
A
556
78.273
−19.924
2.693
1.00
31.81
A
N


ATOM
8569
CA
LEU
A
556
79.736
−19.843
2.571
1.00
33.19
A
C


ATOM
8571
CB
LEU
A
556
80.432
−20.311
3.857
1.00
33.04
A
C


ATOM
8574
CG
LEU
A
556
80.327
−19.370
5.071
1.00
40.15
A
C


ATOM
8576
CD1
LEU
A
556
80.560
−20.126
6.367
1.00
44.82
A
C


ATOM
8580
CD2
LEU
A
556
81.297
−18.182
4.960
1.00
40.79
A
C


ATOM
8584
C
LEU
A
556
80.195
−20.687
1.391
1.00
33.20
A
C


ATOM
8585
O
LEU
A
556
79.754
−21.814
1.234
1.00
34.64
A
O


ATOM
8587
N
PRO
A
557
81.093
−20.150
0.560
1.00
34.80
A
N


ATOM
8588
CA
PRO
A
557
81.389
−20.817
−0.707
1.00
34.59
A
C


ATOM
8590
CB
PRO
A
557
82.379
−19.878
−1.402
1.00
35.42
A
C


ATOM
8593
CG
PRO
A
557
82.956
−19.016
−0.316
1.00
37.04
A
C


ATOM
8596
CD
PRO
A
557
82.005
−19.023
0.846
1.00
35.67
A
C


ATOM
8599
C
PRO
A
557
82.003
−22.187
−0.532
1.00
34.31
A
C


ATOM
8600
O
PRO
A
557
82.598
−22.485
0.497
1.00
34.81
A
O


ATOM
8601
N
PHE
A
558
81.824
−23.015
−1.548
1.00
34.16
A
N


ATOM
8602
CA
PHE
A
558
82.422
−24.328
−1.595
1.00
34.90
A
C


ATOM
8604
CB
PHE
A
558
82.071
−24.950
−2.929
1.00
32.02
A
C


ATOM
8607
CG
PHE
A
558
82.786
−26.220
−3.210
1.00
33.45
A
C


ATOM
8608
CD1
PHE
A
558
83.795
−26.268
−4.157
1.00
35.45
A
C


ATOM
8610
CE1
PHE
A
558
84.443
−27.463
−4.429
1.00
39.71
A
C


ATOM
8612
CZ
PHE
A
558
84.082
−28.618
−3.750
1.00
40.59
A
C


ATOM
8614
CE2
PHE
A
558
83.074
−28.575
−2.805
1.00
37.21
A
C


ATOM
8616
CD2
PHE
A
558
82.440
−27.382
−2.536
1.00
34.24
A
C


ATOM
8618
C
PHE
A
558
83.950
−24.247
−1.466
1.00
37.69
A
C


ATOM
8619
O
PHE
A
558
84.563
−23.354
−2.050
1.00
35.80
A
O


ATOM
8621
N
GLU
A
559
84.547
−25.183
−0.726
1.00
42.77
A
N


ATOM
8622
CA
GLU
A
559
86.019
−25.260
−0.597
1.00
49.59
A
C


ATOM
8624
CB
GLU
A
559
86.454
−25.349
0.882
1.00
50.56
A
C


ATOM
8627
CG
GLU
A
559
86.515
−23.989
1.607
1.00
54.49
A
C


ATOM
8630
CD
GLU
A
559
87.615
−23.913
2.683
1.00
62.33
A
C


ATOM
8631
OE1
GLU
A
559
88.034
−24.964
3.225
1.00
60.02
A
O


ATOM
8632
OE2
GLU
A
559
88.065
−22.786
2.989
1.00
62.02
A
O


ATOM
8633
C
GLU
A
559
86.678
−26.368
−1.464
1.00
52.68
A
C


ATOM
8634
O
GLU
A
559
86.943
−26.123
−2.636
1.00
54.35
A
O


ATOM
8636
N
ARG
A
560
86.938
−27.551
−0.895
1.00
55.62
A
N


ATOM
8637
CA
ARG
A
560
87.722
−28.662
−1.529
1.00
58.23
A
C


ATOM
8639
CB
ARG
A
560
88.710
−28.199
−2.636
1.00
59.46
A
C


ATOM
8642
CG
ARG
A
560
88.211
−28.475
−4.084
1.00
65.26
A
C


ATOM
8645
CD
ARG
A
560
88.672
−27.426
−5.136
1.00
70.99
A
C


ATOM
8648
NE
ARG
A
560
87.572
−27.065
−6.051
1.00
76.26
A
N


ATOM
8650
CZ
ARG
A
560
87.471
−25.927
−6.754
1.00
78.60
A
C


ATOM
8651
NH1
ARG
A
560
88.419
−24.990
−6.703
1.00
78.10
A
N


ATOM
8654
NH2
ARG
A
560
86.402
−25.724
−7.529
1.00
77.34
A
N


ATOM
8657
C
ARG
A
560
88.497
−29.449
−0.470
1.00
57.56
A
C


ATOM
8658
O
ARG
A
560
89.485
−28.950
0.077
1.00
57.69
A
O


ATOM
8660
N
ALA
B
23
68.865
37.021
10.784
1.00
63.55
B
N


ATOM
8661
CA
ALA
B
23
69.934
36.293
10.034
1.00
63.42
B
C


ATOM
8663
CB
ALA
B
23
71.193
36.204
10.865
1.00
63.20
B
C


ATOM
8667
C
ALA
B
23
69.468
34.898
9.638
1.00
63.10
B
C


ATOM
8668
O
ALA
B
23
68.478
34.404
10.177
1.00
63.23
B
O


ATOM
8672
N
ASN
B
24
70.182
34.274
8.698
1.00
62.83
B
N


ATOM
8673
CA
ASN
B
24
69.852
32.919
8.208
1.00
62.89
B
C


ATOM
8675
CB
ASN
B
24
68.986
33.004
6.939
1.00
64.13
B
C


ATOM
8678
CG
ASN
B
24
68.555
31.630
6.414
1.00
66.01
B
C


ATOM
8679
OD1
ASN
B
24
67.998
30.809
7.149
1.00
66.06
B
O


ATOM
8680
ND2
ASN
B
24
68.801
31.389
5.132
1.00
66.01
B
N


ATOM
8683
C
ASN
B
24
71.083
32.041
7.929
1.00
60.68
B
C


ATOM
8684
O
ASN
B
24
71.878
32.334
7.029
1.00
60.33
B
O


ATOM
8686
N
TYR
B
25
71.215
30.959
8.699
1.00
58.42
B
N


ATOM
8687
CA
TYR
B
25
72.299
29.991
8.529
1.00
56.45
B
C


ATOM
8689
CB
TYR
B
25
73.034
29.771
9.854
1.00
54.20
B
C


ATOM
8692
CG
TYR
B
25
73.585
31.045
10.447
1.00
45.61
B
C


ATOM
8693
CD1
TYR
B
25
74.573
31.785
9.789
1.00
37.42
B
C


ATOM
8695
CE1
TYR
B
25
75.070
32.965
10.343
1.00
34.67
B
C


ATOM
8697
CZ
TYR
B
25
74.575
33.398
11.567
1.00
26.79
B
C


ATOM
8698
OH
TYR
B
25
75.031
34.555
12.166
1.00
22.69
B
O


ATOM
8700
CE2
TYR
B
25
73.602
32.674
12.215
1.00
26.03
B
C


ATOM
8702
CD2
TYR
B
25
73.112
31.521
11.660
1.00
34.02
B
C


ATOM
8704
C
TYR
B
25
71.835
28.640
7.990
1.00
57.64
B
C


ATOM
8705
O
TYR
B
25
72.641
27.717
7.901
1.00
57.97
B
O


ATOM
8707
N
GLU
B
26
70.560
28.511
7.620
1.00
59.08
B
N


ATOM
8708
CA
GLU
B
26
70.045
27.223
7.118
1.00
60.48
B
C


ATOM
8710
CB
GLU
B
26
68.510
27.159
7.198
1.00
61.50
B
C


ATOM
8713
CG
GLU
B
26
67.992
27.065
8.651
1.00
68.14
B
C


ATOM
8716
CD
GLU
B
26
66.579
26.483
8.775
1.00
76.80
B
C


ATOM
8717
OE1
GLU
B
26
66.038
25.934
7.784
1.00
81.59
B
O


ATOM
8718
OE2
GLU
B
26
66.008
26.568
9.885
1.00
80.08
B
O


ATOM
8719
C
GLU
B
26
70.551
26.918
5.694
1.00
58.35
B
C


ATOM
8720
O
GLU
B
26
70.748
27.837
4.898
1.00
55.74
B
O


ATOM
8722
N
PRO
B
27
70.785
25.623
5.389
1.00
58.14
B
N


ATOM
8723
CA
PRO
B
27
71.383
25.254
4.106
1.00
57.29
B
C


ATOM
8725
CB
PRO
B
27
71.677
23.759
4.265
1.00
58.74
B
C


ATOM
8728
CG
PRO
B
27
70.648
23.277
5.248
1.00
58.92
B
C


ATOM
8731
CD
PRO
B
27
70.460
24.434
6.207
1.00
58.03
B
C


ATOM
8734
C
PRO
B
27
70.427
25.464
2.951
1.00
56.06
B
C


ATOM
8735
O
PRO
B
27
69.206
25.463
3.137
1.00
56.00
B
O


ATOM
8736
N
ASN
B
28
70.993
25.657
1.768
1.00
54.96
B
N


ATOM
8737
CA
ASN
B
28
70.214
25.706
0.536
1.00
54.67
B
C


ATOM
8739
CB
ASN
B
28
70.821
26.721
−0.448
1.00
55.69
B
C


ATOM
8742
CG
ASN
B
28
71.032
28.083
0.184
1.00
56.97
B
C


ATOM
8743
OD1
ASN
B
28
70.102
28.660
0.744
1.00
59.86
B
O


ATOM
8744
ND2
ASN
B
28
72.262
28.593
0.118
1.00
57.20
B
N


ATOM
8747
C
ASN
B
28
70.152
24.318
−0.095
1.00
52.96
B
C


ATOM
8748
O
ASN
B
28
71.036
23.469
0.110
1.00
50.45
B
O


ATOM
8750
N
SER
B
29
69.092
24.090
−0.858
1.00
52.74
B
N


ATOM
8751
CA
SER
B
29
68.943
22.848
−1.620
1.00
53.12
B
C


ATOM
8753
CB
SER
B
29
67.530
22.783
−2.229
1.00
53.87
B
C


ATOM
8756
OG
SER
B
29
67.129
24.045
−2.769
1.00
50.23
B
O


ATOM
8758
C
SER
B
29
70.021
22.689
−2.717
1.00
52.24
B
C


ATOM
8759
O
SER
B
29
70.258
21.579
−3.202
1.00
53.74
B
O


ATOM
8761
N
TRP
B
30
70.662
23.796
−3.095
1.00
50.38
B
N


ATOM
8762
CA
TRP
B
30
71.696
23.793
−4.132
1.00
49.96
B
C


ATOM
8764
CB
TRP
B
30
71.494
24.969
−5.109
1.00
49.93
B
C


ATOM
8767
CG
TRP
B
30
71.028
26.273
−4.513
1.00
51.10
B
C


ATOM
8768
CD1
TRP
B
30
69.736
26.720
−4.435
1.00
57.17
B
C


ATOM
8770
NE1
TRP
B
30
69.700
27.965
−3.840
1.00
60.59
B
N


ATOM
8772
CE2
TRP
B
30
70.981
28.348
−3.534
1.00
55.40
B
C


ATOM
8773
CD2
TRP
B
30
71.846
27.311
−3.947
1.00
52.14
B
C


ATOM
8774
CE3
TRP
B
30
73.224
27.459
−3.736
1.00
57.76
B
C


ATOM
8776
CZ3
TRP
B
30
73.692
28.628
−3.134
1.00
59.65
B
C


ATOM
8778
CH2
TRP
B
30
72.807
29.640
−2.735
1.00
60.19
B
C


ATOM
8780
CZ2
TRP
B
30
71.450
29.517
−2.921
1.00
60.67
B
C


ATOM
8782
C
TRP
B
30
73.158
23.763
−3.617
1.00
48.98
B
C


ATOM
8783
O
TRP
B
30
74.074
23.547
−4.408
1.00
47.49
B
O


ATOM
8785
N
ASP
B
31
73.376
23.974
−2.317
1.00
47.96
B
N


ATOM
8786
CA
ASP
B
31
74.734
23.951
−1.732
1.00
47.91
B
C


ATOM
8788
CB
ASP
B
31
74.661
24.026
−0.202
1.00
47.75
B
C


ATOM
8791
CG
ASP
B
31
74.301
25.413
0.310
1.00
50.81
B
C


ATOM
8792
OD1
ASP
B
31
74.399
26.417
−0.447
1.00
52.74
B
O


ATOM
8793
OD2
ASP
B
31
73.939
25.489
1.505
1.00
54.84
B
O


ATOM
8794
C
ASP
B
31
75.545
22.705
−2.113
1.00
47.82
B
C


ATOM
8795
O
ASP
B
31
74.989
21.614
−2.241
1.00
46.75
B
O


ATOM
8797
N
TYR
B
32
76.861
22.863
−2.267
1.00
47.95
B
N


ATOM
8798
CA
TYR
B
32
77.729
21.724
−2.620
1.00
48.39
B
C


ATOM
8800
CB
TYR
B
32
79.107
22.187
−3.111
1.00
46.33
B
C


ATOM
8803
CG
TYR
B
32
79.061
22.966
−4.404
1.00
42.06
B
C


ATOM
8804
CD1
TYR
B
32
78.597
22.375
−5.600
1.00
32.87
B
C


ATOM
8806
CE1
TYR
B
32
78.565
23.094
−6.785
1.00
24.91
B
C


ATOM
8808
CZ
TYR
B
32
78.983
24.416
−6.780
1.00
29.67
B
C


ATOM
8809
OH
TYR
B
32
78.959
25.162
−7.917
1.00
28.02
B
O


ATOM
8811
CE2
TYR
B
32
79.435
25.021
−5.609
1.00
33.06
B
C


ATOM
8813
CD2
TYR
B
32
79.481
24.295
−4.442
1.00
38.13
B
C


ATOM
8815
C
TYR
B
32
77.912
20.694
−1.496
1.00
50.79
B
C


ATOM
8816
O
TYR
B
32
78.332
19.566
−1.774
1.00
49.23
B
O


ATOM
8818
N
ASP
B
33
77.621
21.082
−0.247
1.00
54.28
B
N


ATOM
8819
CA
ASP
B
33
77.619
20.140
0.897
1.00
56.96
B
C


ATOM
8821
CB
ASP
B
33
77.480
20.882
2.244
1.00
56.67
B
C


ATOM
8824
CG
ASP
B
33
78.786
21.540
2.715
1.00
54.94
B
C


ATOM
8825
OD1
ASP
B
33
79.876
21.054
2.353
1.00
51.15
B
O


ATOM
8826
OD2
ASP
B
33
78.720
22.540
3.471
1.00
53.38
B
O


ATOM
8827
C
ASP
B
33
76.479
19.130
0.751
1.00
60.30
B
C


ATOM
8828
O
ASP
B
33
76.675
17.922
0.940
1.00
59.85
B
O


ATOM
8830
N
TYR
B
34
75.299
19.650
0.402
1.00
64.90
B
N


ATOM
8831
CA
TYR
B
34
74.073
18.860
0.224
1.00
69.43
B
C


ATOM
8833
CB
TYR
B
34
72.841
19.789
0.239
1.00
70.86
B
C


ATOM
8836
CG
TYR
B
34
71.502
19.080
0.363
1.00
79.22
B
C


ATOM
8837
CD1
TYR
B
34
70.964
18.781
1.617
1.00
87.20
B
C


ATOM
8839
CE1
TYR
B
34
69.737
18.137
1.740
1.00
89.29
B
C


ATOM
8841
CZ
TYR
B
34
69.029
17.792
0.600
1.00
92.08
B
C


ATOM
8842
OH
TYR
B
34
67.812
17.157
0.722
1.00
95.47
B
O


ATOM
8844
CE2
TYR
B
34
69.537
18.085
−0.659
1.00
89.29
B
C


ATOM
8846
CD2
TYR
B
34
70.767
18.728
−0.770
1.00
85.21
B
C


ATOM
8848
C
TYR
B
34
74.118
18.028
−1.070
1.00
70.87
B
C


ATOM
8849
O
TYR
B
34
73.976
16.808
−1.022
1.00
71.02
B
O


ATOM
8851
N
LEU
B
35
74.306
18.686
−2.217
1.00
73.23
B
N


ATOM
8852
CA
LEU
B
35
74.646
17.990
−3.465
1.00
75.05
B
C


ATOM
8854
CB
LEU
B
35
74.518
18.928
−4.672
1.00
73.87
B
C


ATOM
8857
CG
LEU
B
35
73.181
19.646
−4.918
1.00
72.69
B
C


ATOM
8859
CD1
LEU
B
35
73.321
20.646
−6.063
1.00
69.30
B
C


ATOM
8863
CD2
LEU
B
35
72.033
18.678
−5.204
1.00
66.46
B
C


ATOM
8867
C
LEU
B
35
76.092
17.517
−3.304
1.00
78.50
B
C


ATOM
8868
O
LEU
B
35
76.785
17.996
−2.414
1.00
79.84
B
O


ATOM
8870
N
LEU
B
36
76.554
16.580
−4.126
1.00
81.41
B
N


ATOM
8871
CA
LEU
B
36
77.964
16.142
−4.067
1.00
84.34
B
C


ATOM
8873
CB
LEU
B
36
78.905
17.267
−4.546
1.00
84.18
B
C


ATOM
8876
CG
LEU
B
36
79.015
17.545
−6.043
1.00
85.03
B
C


ATOM
8878
CD1
LEU
B
36
79.771
18.850
−6.269
1.00
85.63
B
C


ATOM
8882
CD2
LEU
B
36
79.688
16.379
−6.768
1.00
84.74
B
C


ATOM
8886
C
LEU
B
36
78.429
15.663
−2.676
1.00
86.98
B
C


ATOM
8887
O
LEU
B
36
79.490
16.072
−2.193
1.00
87.19
B
O


ATOM
8889
N
SER
B
37
77.637
14.812
−2.029
1.00
90.52
B
N


ATOM
8890
CA
SER
B
37
78.077
14.126
−0.804
1.00
92.80
B
C


ATOM
8892
CB
SER
B
37
77.125
14.406
0.375
1.00
93.04
B
C


ATOM
8895
OG
SER
B
37
76.054
13.477
0.440
1.00
93.00
B
O


ATOM
8897
C
SER
B
37
78.202
12.623
−1.103
1.00
94.93
B
C


ATOM
8898
O
SER
B
37
77.529
12.105
−2.009
1.00
95.38
B
O


ATOM
8900
N
SER
B
38
79.068
11.936
−0.353
1.00
96.53
B
N


ATOM
8901
CA
SER
B
38
79.407
10.533
−0.635
1.00
97.64
B
C


ATOM
8903
CB
SER
B
38
80.710
10.135
0.070
1.00
97.75
B
C


ATOM
8906
OG
SER
B
38
80.469
9.681
1.391
1.00
98.14
B
O


ATOM
8908
C
SER
B
38
78.277
9.586
−0.222
1.00
98.41
B
C


ATOM
8909
O
SER
B
38
78.104
8.514
−0.802
1.00
98.59
B
O


ATOM
8911
N
ILE
B
44
83.839
12.635
−5.393
1.00
94.49
B
N


ATOM
8912
CA
ILE
B
44
82.761
13.547
−5.022
1.00
93.90
B
C


ATOM
8914
CB
ILE
B
44
81.411
12.780
−4.783
1.00
94.49
B
C


ATOM
8916
CG1
ILE
B
44
81.066
11.873
−5.977
1.00
95.23
B
C


ATOM
8919
CD1
ILE
B
44
79.671
11.239
−5.902
1.00
93.84
B
C


ATOM
8923
CG2
ILE
B
44
80.260
13.748
−4.553
1.00
94.85
B
C


ATOM
8927
C
ILE
B
44
83.150
14.379
−3.786
1.00
92.23
B
C


ATOM
8928
O
ILE
B
44
82.375
15.230
−3.340
1.00
92.29
B
O


ATOM
8930
N
GLU
B
45
84.357
14.149
−3.257
1.00
89.93
B
N


ATOM
8931
CA
GLU
B
45
84.858
14.871
−2.079
1.00
88.17
B
C


ATOM
8933
CB
GLU
B
45
85.549
13.906
−1.114
1.00
88.70
B
C


ATOM
8936
CG
GLU
B
45
84.632
12.834
−0.533
1.00
91.80
B
C


ATOM
8939
CD
GLU
B
45
85.373
11.838
0.361
1.00
95.23
B
C


ATOM
8940
OE1
GLU
B
45
86.408
12.215
0.962
1.00
95.84
B
O


ATOM
8941
OE2
GLU
B
45
84.916
10.676
0.465
1.00
93.58
B
O


ATOM
8942
C
GLU
B
45
85.821
16.011
−2.435
1.00
85.13
B
C


ATOM
8943
O
GLU
B
45
85.588
17.159
−2.053
1.00
84.84
B
O


ATOM
8945
N
VAL
B
46
86.909
15.693
−3.139
1.00
81.48
B
N


ATOM
8946
CA
VAL
B
46
87.890
16.710
−3.562
1.00
78.17
B
C


ATOM
8948
CB
VAL
B
46
89.203
16.066
−4.107
1.00
78.25
B
C


ATOM
8950
CG1
VAL
B
46
90.111
17.117
−4.756
1.00
77.80
B
C


ATOM
8954
CG2
VAL
B
46
89.942
15.339
−2.989
1.00
78.65
B
C


ATOM
8958
C
VAL
B
46
87.271
17.647
−4.609
1.00
74.01
B
C


ATOM
8959
O
VAL
B
46
87.633
18.815
−4.691
1.00
74.42
B
O


ATOM
8961
N
TYR
B
47
86.343
17.111
−5.397
1.00
68.89
B
N


ATOM
8962
CA
TYR
B
47
85.530
17.877
−6.341
1.00
65.57
B
C


ATOM
8964
CB
TYR
B
47
84.662
16.884
−7.117
1.00
65.80
B
C


ATOM
8967
CG
TYR
B
47
83.812
17.399
−8.261
1.00
68.62
B
C


ATOM
8968
CD1
TYR
B
47
84.261
17.333
−9.579
1.00
72.47
B
C


ATOM
8970
CE1
TYR
B
47
83.452
17.766
−10.647
1.00
72.49
B
C


ATOM
8972
CZ
TYR
B
47
82.165
18.246
−10.397
1.00
73.07
B
C


ATOM
8973
OH
TYR
B
47
81.346
18.679
−11.437
1.00
56.23
B
O


ATOM
8975
CE2
TYR
B
47
81.697
18.296
−9.090
1.00
72.24
B
C


ATOM
8977
CD2
TYR
B
47
82.516
17.861
−8.036
1.00
72.42
B
C


ATOM
8979
C
TYR
B
47
84.670
18.905
−5.585
1.00
61.56
B
C


ATOM
8980
O
TYR
B
47
84.605
20.068
−5.981
1.00
60.03
B
O


ATOM
8982
N
LYS
B
48
84.041
18.471
−4.488
1.00
57.03
B
N


ATOM
8983
CA
LYS
B
48
83.250
19.350
−3.606
1.00
53.54
B
C


ATOM
8985
CB
LYS
B
48
82.637
18.549
−2.448
1.00
53.56
B
C


ATOM
8988
CG
LYS
B
48
81.822
19.383
−1.449
1.00
55.92
B
C


ATOM
8991
CD
LYS
B
48
81.250
18.518
−0.323
1.00
61.31
B
C


ATOM
8994
CE
LYS
B
48
82.258
18.292
0.806
1.00
65.33
B
C


ATOM
8997
NZ
LYS
B
48
81.669
17.565
1.968
1.00
65.45
B
N


ATOM
9001
C
LYS
B
48
84.064
20.505
−3.023
1.00
49.39
B
C


ATOM
9002
O
LYS
B
48
83.614
21.643
−3.014
1.00
48.79
B
O


ATOM
9004
N
ASP
B
49
85.252
20.197
−2.526
1.00
45.46
B
N


ATOM
9005
CA
ASP
B
49
86.102
21.189
−1.878
1.00
44.14
B
C


ATOM
9007
CB
ASP
B
49
87.217
20.505
−1.049
1.00
45.26
B
C


ATOM
9010
CG
ASP
B
49
86.675
19.718
0.166
1.00
48.58
B
C


ATOM
9011
OD1
ASP
B
49
85.493
19.908
0.553
1.00
51.70
B
O


ATOM
9012
OD2
ASP
B
49
87.447
18.916
0.745
1.00
47.26
B
O


ATOM
9013
C
ASP
B
49
86.707
22.135
−2.910
1.00
40.94
B
C


ATOM
9014
O
ASP
B
49
87.065
23.274
−2.581
1.00
38.32
B
O


ATOM
9016
N
LYS
B
50
86.830
21.655
−4.151
1.00
38.29
B
N


ATOM
9017
CA
LYS
B
50
87.259
22.502
−5.260
1.00
36.73
B
C


ATOM
9019
CB
LYS
B
50
87.580
21.669
−6.500
1.00
38.18
B
C


ATOM
9022
CG
LYS
B
50
88.431
22.387
−7.554
1.00
44.48
B
C


ATOM
9025
CD
LYS
B
50
89.936
22.153
−7.346
1.00
56.72
B
C


ATOM
9028
CE
LYS
B
50
90.744
22.329
−8.644
1.00
59.64
B
C


ATOM
9031
NZ
LYS
B
50
90.457
21.259
−9.654
1.00
56.87
B
N


ATOM
9035
C
LYS
B
50
86.141
23.497
−5.555
1.00
33.08
B
C


ATOM
9036
O
LYS
B
50
86.391
24.692
−5.665
1.00
32.79
B
O


ATOM
9038
N
ALA
B
51
84.905
23.011
−5.635
1.00
28.99
B
N


ATOM
9039
CA
ALA
B
51
83.779
23.878
−5.971
1.00
28.45
B
C


ATOM
9041
CB
ALA
B
51
82.493
23.070
−6.203
1.00
26.35
B
C


ATOM
9045
C
ALA
B
51
83.570
24.969
−4.908
1.00
25.62
B
C


ATOM
9046
O
ALA
B
51
83.382
26.125
−5.250
1.00
27.03
B
O


ATOM
9048
N
LYS
B
52
83.640
24.605
−3.639
1.00
23.23
B
N


ATOM
9049
CA
LYS
B
52
83.402
25.549
−2.558
1.00
25.12
B
C


ATOM
9051
CB
LYS
B
52
83.462
24.826
−1.222
1.00
26.00
B
C


ATOM
9054
CG
LYS
B
52
82.247
23.917
−0.950
1.00
32.90
B
C


ATOM
9057
CD
LYS
B
52
82.548
22.836
0.119
1.00
33.42
B
C


ATOM
9060
CE
LYS
B
52
82.519
23.382
1.545
1.00
38.08
B
C


ATOM
9063
NZ
LYS
B
52
83.221
22.478
2.543
1.00
41.70
B
N


ATOM
9067
C
LYS
B
52
84.382
26.734
−2.559
1.00
25.93
B
C


ATOM
9068
O
LYS
B
52
83.977
27.889
−2.356
1.00
25.95
B
O


ATOM
9070
N
LYS
B
53
85.659
26.441
−2.800
1.00
24.65
B
N


ATOM
9071
CA
LYS
B
53
86.713
27.468
−2.865
1.00
26.16
B
C


ATOM
9073
CB
LYS
B
53
88.072
26.795
−3.053
1.00
28.69
B
C


ATOM
9076
CG
LYS
B
53
89.272
27.687
−2.785
1.00
38.87
B
C


ATOM
9079
CD
LYS
B
53
90.559
26.848
−2.633
1.00
49.83
B
C


ATOM
9082
CE
LYS
B
53
91.819
27.730
−2.464
1.00
57.01
B
C


ATOM
9085
NZ
LYS
B
53
91.931
28.843
−3.484
1.00
55.43
B
N


ATOM
9089
C
LYS
B
53
86.476
28.458
−4.011
1.00
23.98
B
C


ATOM
9090
O
LYS
B
53
86.553
29.666
−3.818
1.00
22.54
B
O


ATOM
9092
N
LEU
B
54
86.180
27.918
−5.188
1.00
22.61
B
N


ATOM
9093
CA
LEU
B
54
85.881
28.705
−6.377
1.00
23.43
B
C


ATOM
9095
CB
LEU
B
54
85.746
27.787
−7.601
1.00
25.24
B
C


ATOM
9098
CG
LEU
B
54
86.885
26.810
−7.946
1.00
24.59
B
C


ATOM
9100
CD1
LEU
B
54
86.382
25.820
−8.997
1.00
16.54
B
C


ATOM
9104
CD2
LEU
B
54
88.140
27.524
−8.433
1.00
26.50
B
C


ATOM
9108
C
LEU
B
54
84.602
29.524
−6.185
1.00
22.18
B
C


ATOM
9109
O
LEU
B
54
84.580
30.696
−6.496
1.00
20.99
B
O


ATOM
9111
N
GLU
B
55
83.544
28.909
−5.656
1.00
21.18
B
N


ATOM
9112
CA
GLU
B
55
82.297
29.631
−5.346
1.00
19.85
B
C


ATOM
9114
CB
GLU
B
55
81.221
28.667
−4.811
1.00
19.93
B
C


ATOM
9117
CG
GLU
B
55
79.945
29.338
−4.252
1.00
21.78
B
C


ATOM
9120
CD
GLU
B
55
78.928
28.318
−3.683
1.00
25.47
B
C


ATOM
9121
OE1
GLU
B
55
79.358
27.408
−2.970
1.00
25.89
B
O


ATOM
9122
OE2
GLU
B
55
77.712
28.432
−3.943
1.00
30.12
B
O


ATOM
9123
C
GLU
B
55
82.507
30.751
−4.333
1.00
16.88
B
C


ATOM
9124
O
GLU
B
55
81.902
31.810
−4.444
1.00
18.42
B
O


ATOM
9126
N
ALA
B
56
83.331
30.498
−3.332
1.00
17.01
B
N


ATOM
9127
CA
ALA
B
56
83.662
31.512
−2.318
1.00
17.77
B
C


ATOM
9129
CB
ALA
B
56
84.639
30.933
−1.285
1.00
14.61
B
C


ATOM
9133
C
ALA
B
56
84.260
32.750
−2.974
1.00
16.65
B
C


ATOM
9134
O
ALA
B
56
83.866
33.892
−2.698
1.00
17.77
B
O


ATOM
9136
N
GLU
B
57
85.192
32.504
−3.881
1.00
17.66
B
N


ATOM
9137
CA
GLU
B
57
85.891
33.568
−4.576
1.00
19.52
B
C


ATOM
9139
CB
GLU
B
57
87.061
32.978
−5.370
1.00
20.51
B
C


ATOM
9142
CG
GLU
B
57
87.856
34.013
−6.123
1.00
28.03
B
C


ATOM
9145
CD
GLU
B
57
89.220
33.529
−6.584
1.00
29.71
B
C


ATOM
9146
OE1
GLU
B
57
89.788
32.582
−5.980
1.00
32.81
B
O


ATOM
9147
OE2
GLU
B
57
89.714
34.123
−7.558
1.00
32.47
B
O


ATOM
9148
C
GLU
B
57
84.926
34.373
−5.464
1.00
18.10
B
C


ATOM
9149
O
GLU
B
57
84.956
35.612
−5.451
1.00
17.86
B
O


ATOM
9151
N
VAL
B
58
84.052
33.683
−6.201
1.00
15.98
B
N


ATOM
9152
CA
VAL
B
58
83.038
34.371
−6.998
1.00
15.98
B
C


ATOM
9154
CB
VAL
B
58
82.222
33.394
−7.875
1.00
18.04
B
C


ATOM
9156
CG1
VAL
B
58
81.131
34.128
−8.663
1.00
15.64
B
C


ATOM
9160
CG2
VAL
B
58
83.138
32.696
−8.844
1.00
18.23
B
C


ATOM
9164
C
VAL
B
58
82.135
35.203
−6.089
1.00
14.38
B
C


ATOM
9165
O
VAL
B
58
81.813
36.330
−6.395
1.00
12.91
B
O


ATOM
9167
N
ARG
B
59
81.773
34.666
−4.935
1.00
18.23
B
N


ATOM
9168
CA
ARG
B
59
80.953
35.412
−3.976
1.00
19.65
B
C


ATOM
9170
CB
ARG
B
59
80.619
34.534
−2.741
1.00
22.03
B
C


ATOM
9173
CG
ARG
B
59
79.877
35.245
−1.579
1.00
22.47
B
C


ATOM
9176
CD
ARG
B
59
80.840
36.086
−0.641
1.00
25.58
B
C


ATOM
9179
NE
ARG
B
59
80.117
36.788
0.431
1.00
24.31
B
N


ATOM
9181
CZ
ARG
B
59
80.644
37.698
1.250
1.00
27.67
B
C


ATOM
9182
NH1
ARG
B
59
79.881
38.260
2.182
1.00
25.80
B
N


ATOM
9185
NH2
ARG
B
59
81.926
38.056
1.146
1.00
25.89
B
N


ATOM
9188
C
ARG
B
59
81.673
36.705
−3.578
1.00
19.80
B
C


ATOM
9189
O
ARG
B
59
81.077
37.780
−3.578
1.00
21.68
B
O


ATOM
9191
N
ARG
B
60
82.953
36.603
−3.241
1.00
20.03
B
N


ATOM
9192
CA
ARG
B
60
83.717
37.782
−2.820
1.00
18.94
B
C


ATOM
9194
CB
ARG
B
60
85.145
37.411
−2.468
1.00
19.04
B
C


ATOM
9197
CG
ARG
B
60
86.020
38.589
−2.002
1.00
22.87
B
C


ATOM
9200
CD
ARG
B
60
87.442
38.164
−1.777
1.00
19.95
B
C


ATOM
9203
NE
ARG
B
60
88.075
37.838
−3.049
1.00
25.88
B
N


ATOM
9205
CZ
ARG
B
60
89.176
37.106
−3.209
1.00
26.18
B
C


ATOM
9206
NH1
ARG
B
60
89.836
36.578
−2.176
1.00
24.93
B
N


ATOM
9209
NH2
ARG
B
60
89.620
36.904
−4.435
1.00
23.40
B
N


ATOM
9212
C
ARG
B
60
83.718
38.843
−3.915
1.00
18.30
B
C


ATOM
9213
O
ARG
B
60
83.427
40.007
−3.650
1.00
16.21
B
O


ATOM
9215
N
GLU
B
61
84.015
38.434
−5.140
1.00
18.15
B
N


ATOM
9216
CA
GLU
B
61
84.066
39.367
−6.264
1.00
18.45
B
C


ATOM
9218
CB
GLU
B
61
84.564
38.663
−7.523
1.00
18.70
B
C


ATOM
9221
CG
GLU
B
61
86.037
38.270
−7.425
1.00
25.62
B
C


ATOM
9224
CD
GLU
B
61
86.901
39.429
−6.970
1.00
31.59
B
C


ATOM
9225
OE1
GLU
B
61
86.893
40.488
−7.648
1.00
33.81
B
O


ATOM
9226
OE2
GLU
B
61
87.559
39.290
−5.918
1.00
30.53
B
O


ATOM
9227
C
GLU
B
61
82.734
40.062
−6.528
1.00
17.97
B
C


ATOM
9228
O
GLU
B
61
82.711
41.245
−6.761
1.00
19.38
B
O


ATOM
9230
N
ILE
B
62
81.617
39.356
−6.435
1.00
17.52
B
N


ATOM
9231
CA
ILE
B
62
80.341
40.023
−6.594
1.00
18.58
B
C


ATOM
9233
CB
ILE
B
62
79.169
39.006
−6.731
1.00
19.89
B
C


ATOM
9235
CG1
ILE
B
62
79.343
38.137
−7.974
1.00
21.73
B
C


ATOM
9238
CD1
ILE
B
62
78.456
36.881
−8.000
1.00
15.32
B
C


ATOM
9242
CG2
ILE
B
62
77.810
39.738
−6.823
1.00
21.38
B
C


ATOM
9246
C
ILE
B
62
80.071
41.005
−5.433
1.00
19.09
B
C


ATOM
9247
O
ILE
B
62
79.379
41.984
−5.615
1.00
20.23
B
O


ATOM
9249
N
ASN
B
63
80.606
40.732
−4.244
1.00
20.89
B
N


ATOM
9250
CA
ASN
B
63
80.300
41.510
−3.024
1.00
21.02
B
C


ATOM
9252
CB
ASN
B
63
80.355
40.597
−1.783
1.00
20.11
B
C


ATOM
9255
CG
ASN
B
63
79.061
39.859
−1.543
1.00
25.79
B
C


ATOM
9256
OD1
ASN
B
63
78.128
40.417
−0.976
1.00
29.46
B
O


ATOM
9257
ND2
ASN
B
63
78.999
38.591
−1.957
1.00
22.36
B
N


ATOM
9260
C
ASN
B
63
81.262
42.671
−2.838
1.00
23.00
B
C


ATOM
9261
O
ASN
B
63
81.077
43.514
−1.968
1.00
22.33
B
O


ATOM
9263
N
ASN
B
64
82.292
42.697
−3.674
1.00
25.47
B
N


ATOM
9264
CA
ASN
B
64
83.322
43.708
−3.630
1.00
27.17
B
C


ATOM
9266
CB
ASN
B
64
84.400
43.341
−4.646
1.00
28.05
B
C


ATOM
9269
CG
ASN
B
64
85.562
44.319
−4.642
1.00
28.60
B
C


ATOM
9270
OD1
ASN
B
64
85.793
45.052
−3.663
1.00
21.94
B
O


ATOM
9271
ND2
ASN
B
64
86.299
44.331
−5.732
1.00
18.57
B
N


ATOM
9274
C
ASN
B
64
82.840
45.121
−3.922
1.00
29.58
B
C


ATOM
9275
O
ASN
B
64
82.518
45.441
−5.073
1.00
30.80
B
O


ATOM
9277
N
GLU
B
65
82.848
45.977
−2.901
1.00
31.46
B
N


ATOM
9278
CA
GLU
B
65
82.308
47.333
−3.039
1.00
34.52
B
C


ATOM
9280
CB
GLU
B
65
81.787
47.849
−1.680
1.00
36.07
B
C


ATOM
9283
CG
GLU
B
65
80.519
47.079
−1.202
1.00
40.76
B
C


ATOM
9286
CD
GLU
B
65
79.853
47.631
0.070
1.00
46.69
B
C


ATOM
9287
OE1
GLU
B
65
79.267
46.807
0.819
1.00
45.52
B
O


ATOM
9288
OE2
GLU
B
65
79.891
48.862
0.314
1.00
44.38
B
O


ATOM
9289
C
GLU
B
65
83.299
48.314
−3.700
1.00
34.91
B
C


ATOM
9290
O
GLU
B
65
82.903
49.396
−4.110
1.00
35.59
B
O


ATOM
9292
N
LYS
B
66
84.561
47.909
−3.843
1.00
34.28
B
N


ATOM
9293
CA
LYS
B
66
85.599
48.730
−4.488
1.00
35.18
B
C


ATOM
9295
CB
LYS
B
66
86.982
48.469
−3.863
1.00
35.99
B
C


ATOM
9298
CG
LYS
B
66
87.045
48.467
−2.339
1.00
38.17
B
C


ATOM
9301
CD
LYS
B
66
88.463
48.112
−1.873
1.00
44.44
B
C


ATOM
9304
CE
LYS
B
66
88.568
47.948
−0.356
1.00
45.69
B
C


ATOM
9307
NZ
LYS
B
66
87.722
48.925
0.382
1.00
46.38
B
N


ATOM
9311
C
LYS
B
66
85.706
48.474
−5.997
1.00
33.33
B
C


ATOM
9312
O
LYS
B
66
86.472
49.135
−6.685
1.00
31.57
B
O


ATOM
9314
N
ALA
B
67
84.959
47.506
−6.507
1.00
33.36
B
N


ATOM
9315
CA
ALA
B
67
85.026
47.165
−7.925
1.00
34.20
B
C


ATOM
9317
CB
ALA
B
67
84.218
45.897
−8.204
1.00
33.29
B
C


ATOM
9321
C
ALA
B
67
84.525
48.322
−8.800
1.00
33.66
B
C


ATOM
9322
O
ALA
B
67
83.650
49.084
−8.405
1.00
30.94
B
O


ATOM
9324
N
GLU
B
68
85.105
48.461
−9.983
1.00
35.83
B
N


ATOM
9325
CA
GLU
B
68
84.593
49.428
−10.952
1.00
38.70
B
C


ATOM
9327
CB
GLU
B
68
85.515
49.528
−12.176
1.00
40.06
B
C


ATOM
9330
CG
GLU
B
68
85.648
50.931
−12.771
1.00
49.30
B
C


ATOM
9333
CD
GLU
B
68
86.723
51.762
−12.087
1.00
60.51
B
C


ATOM
9334
OE1
GLU
B
68
86.676
51.895
−10.839
1.00
64.15
B
O


ATOM
9335
OE2
GLU
B
68
87.615
52.287
−12.800
1.00
64.74
B
O


ATOM
9336
C
GLU
B
68
83.188
48.938
−11.336
1.00
38.52
B
C


ATOM
9337
O
GLU
B
68
82.979
47.736
−11.557
1.00
35.34
B
O


ATOM
9339
N
PHE
B
69
82.231
49.862
−11.388
1.00
39.72
B
N


ATOM
9340
CA
PHE
B
69
80.824
49.499
−11.583
1.00
40.88
B
C


ATOM
9342
CB
PHE
B
69
79.890
50.704
−11.385
1.00
43.17
B
C


ATOM
9345
CG
PHE
B
69
79.457
50.916
−9.936
1.00
53.21
B
C


ATOM
9346
CD1
PHE
B
69
78.868
49.875
−9.202
1.00
61.30
B
C


ATOM
9348
CE1
PHE
B
69
78.463
50.062
−7.870
1.00
62.25
B
C


ATOM
9350
CZ
PHE
B
69
78.638
51.301
−7.260
1.00
64.99
B
C


ATOM
9352
CE2
PHE
B
69
79.218
52.351
−7.978
1.00
65.67
B
C


ATOM
9354
CD2
PHE
B
69
79.621
52.156
−9.312
1.00
63.60
B
C


ATOM
9356
C
PHE
B
69
80.540
48.786
−12.914
1.00
38.20
B
C


ATOM
9357
O
PHE
B
69
79.713
47.862
−12.946
1.00
35.79
B
O


ATOM
9359
N
LEU
B
70
81.237
49.159
−13.983
1.00
34.86
B
N


ATOM
9360
CA
LEU
B
70
81.085
48.435
−15.256
1.00
35.39
B
C


ATOM
9362
CB
LEU
B
70
81.786
49.157
−16.411
1.00
35.66
B
C


ATOM
9365
CG
LEU
B
70
81.573
48.513
−17.786
1.00
42.16
B
C


ATOM
9367
CD1
LEU
B
70
80.104
48.554
−18.171
1.00
42.12
B
C


ATOM
9371
CD2
LEU
B
70
82.425
49.189
−18.855
1.00
49.16
B
C


ATOM
9375
C
LEU
B
70
81.603
46.999
−15.160
1.00
32.47
B
C


ATOM
9376
O
LEU
B
70
80.945
46.071
−15.596
1.00
31.99
B
O


ATOM
9378
N
THR
B
71
82.790
46.834
−14.592
1.00
31.77
B
N


ATOM
9379
CA
THR
B
71
83.396
45.516
−14.366
1.00
30.39
B
C


ATOM
9381
CB
THR
B
71
84.794
45.678
−13.756
1.00
31.06
B
C


ATOM
9383
OG1
THR
B
71
85.585
46.494
−14.633
1.00
34.93
B
O


ATOM
9385
CG2
THR
B
71
85.476
44.322
−13.563
1.00
31.45
B
C


ATOM
9389
C
THR
B
71
82.533
44.619
−13.460
1.00
27.80
B
C


ATOM
9390
O
THR
B
71
82.450
43.412
−13.675
1.00
27.97
B
O


ATOM
9392
N
LEU
B
72
81.878
45.215
−12.467
1.00
25.13
B
N


ATOM
9393
CA
LEU
B
72
80.955
44.476
−11.614
1.00
24.98
B
C


ATOM
9395
CB
LEU
B
72
80.511
45.327
−10.443
1.00
24.24
B
C


ATOM
9398
CG
LEU
B
72
79.716
44.642
−9.339
1.00
33.31
B
C


ATOM
9400
CD1
LEU
B
72
80.492
43.465
−8.715
1.00
32.42
B
C


ATOM
9404
CD2
LEU
B
72
79.346
45.677
−8.266
1.00
35.81
B
C


ATOM
9408
C
LEU
B
72
79.736
44.026
−12.410
1.00
24.17
B
C


ATOM
9409
O
LEU
B
72
79.330
42.888
−12.318
1.00
21.92
B
O


ATOM
9411
N
LEU
B
73
79.158
44.928
−13.196
1.00
24.75
B
N


ATOM
9412
CA
LEU
B
73
78.018
44.568
−14.012
1.00
25.30
B
C


ATOM
9414
CB
LEU
B
73
77.467
45.786
−14.758
1.00
25.87
B
C


ATOM
9417
CG
LEU
B
73
76.666
46.820
−13.948
1.00
26.49
B
C


ATOM
9419
CD1
LEU
B
73
76.237
47.980
−14.845
1.00
24.24
B
C


ATOM
9423
CD2
LEU
B
73
75.462
46.210
−13.265
1.00
20.11
B
C


ATOM
9427
C
LEU
B
73
78.383
43.437
−14.996
1.00
24.80
B
C


ATOM
9428
O
LEU
B
73
77.630
42.492
−15.150
1.00
24.71
B
O


ATOM
9430
N
GLU
B
74
79.530
43.526
−15.650
1.00
23.04
B
N


ATOM
9431
CA
GLU
B
74
79.934
42.456
−16.561
1.00
24.32
B
C


ATOM
9433
CB
GLU
B
74
81.164
42.873
−17.383
1.00
24.31
B
C


ATOM
9436
CG
GLU
B
74
80.842
43.894
−18.492
1.00
35.06
B
C


ATOM
9439
CD
GLU
B
74
82.069
44.669
−19.044
1.00
42.57
B
C


ATOM
9440
OE1
GLU
B
74
83.235
44.254
−18.819
1.00
41.46
B
O


ATOM
9441
OE2
GLU
B
74
81.844
45.714
−19.713
1.00
49.19
B
O


ATOM
9442
C
GLU
B
74
80.187
41.124
−15.811
1.00
23.65
B
C


ATOM
9443
O
GLU
B
74
79.951
40.034
−16.343
1.00
24.23
B
O


ATOM
9445
N
LEU
B
75
80.667
41.208
−14.579
1.00
22.21
B
N


ATOM
9446
CA
LEU
B
75
80.888
40.012
−13.794
1.00
20.79
B
C


ATOM
9448
CB
LEU
B
75
81.548
40.334
−12.445
1.00
19.72
B
C


ATOM
9451
CG
LEU
B
75
81.715
39.168
−11.461
1.00
19.52
B
C


ATOM
9453
CD1
LEU
B
75
82.486
38.032
−12.119
1.00
16.13
B
C


ATOM
9457
CD2
LEU
B
75
82.437
39.647
−10.211
1.00
21.45
B
C


ATOM
9461
C
LEU
B
75
79.553
39.335
−13.576
1.00
19.44
B
C


ATOM
9462
O
LEU
B
75
79.445
38.130
−13.753
1.00
21.48
B
O


ATOM
9464
N
ILE
B
76
78.543
40.115
−13.197
1.00
19.42
B
N


ATOM
9465
CA
ILE
B
76
77.230
39.579
−12.907
1.00
21.46
B
C


ATOM
9467
CB
ILE
B
76
76.256
40.654
−12.379
1.00
23.58
B
C


ATOM
9469
CG1
ILE
B
76
76.708
41.135
−10.996
1.00
24.75
B
C


ATOM
9472
CD1
ILE
B
76
75.987
42.362
−10.509
1.00
22.54
B
C


ATOM
9476
CG2
ILE
B
76
74.826
40.102
−12.297
1.00
15.99
B
C


ATOM
9480
C
ILE
B
76
76.632
38.972
−14.151
1.00
23.08
B
C


ATOM
9481
O
ILE
B
76
75.984
37.933
−14.081
1.00
24.81
B
O


ATOM
9483
N
ASP
B
77
76.854
39.610
−15.293
1.00
23.68
B
N


ATOM
9484
CA
ASP
B
77
76.279
39.122
−16.545
1.00
23.98
B
C


ATOM
9486
CB
ASP
B
77
76.545
40.109
−17.669
1.00
24.72
B
C


ATOM
9489
CG
ASP
B
77
75.708
39.838
−18.906
1.00
28.60
B
C


ATOM
9490
OD1
ASP
B
77
74.657
39.176
−18.811
1.00
27.91
B
O


ATOM
9491
OD2
ASP
B
77
76.095
40.332
−19.984
1.00
33.20
B
O


ATOM
9492
C
ASP
B
77
76.900
37.791
−16.896
1.00
22.93
B
C


ATOM
9493
O
ASP
B
77
76.206
36.855
−17.301
1.00
21.74
B
O


ATOM
9495
N
ASN
B
78
78.211
37.703
−16.733
1.00
21.06
B
N


ATOM
9496
CA
ASN
B
78
78.925
36.463
−17.029
1.00
22.27
B
C


ATOM
9498
CB
ASN
B
78
80.438
36.637
−16.866
1.00
25.30
B
C


ATOM
9501
CG
ASN
B
78
81.081
37.404
−18.019
1.00
26.72
B
C


ATOM
9502
OD1
ASN
B
78
80.708
37.233
−19.156
1.00
23.36
B
O


ATOM
9503
ND2
ASN
B
78
82.081
38.219
−17.714
1.00
21.70
B
N


ATOM
9506
C
ASN
B
78
78.458
35.353
−16.109
1.00
21.56
B
C


ATOM
9507
O
ASN
B
78
78.201
34.240
−16.549
1.00
20.19
B
O


ATOM
9509
N
VAL
B
79
78.340
35.664
−14.825
1.00
20.29
B
N


ATOM
9510
CA
VAL
B
79
77.917
34.672
−13.843
1.00
21.77
B
C


ATOM
9512
CB
VAL
B
79
77.857
35.306
−12.419
1.00
23.62
B
C


ATOM
9514
CG1
VAL
B
79
77.001
34.467
−11.466
1.00
19.36
B
C


ATOM
9518
CG2
VAL
B
79
79.265
35.515
−11.862
1.00
19.30
B
C


ATOM
9522
C
VAL
B
79
76.552
34.064
−14.217
1.00
22.02
B
C


ATOM
9523
O
VAL
B
79
76.349
32.862
−14.107
1.00
22.00
B
O


ATOM
9525
N
GLN
B
80
75.630
34.910
−14.672
1.00
21.01
B
N


ATOM
9526
CA
GLN
B
80
74.265
34.482
−15.024
1.00
19.29
B
C


ATOM
9528
CB
GLN
B
80
73.343
35.686
−15.126
1.00
15.00
B
C


ATOM
9531
CG
GLN
B
80
73.128
36.374
−13.771
1.00
17.76
B
C


ATOM
9534
CD
GLN
B
80
71.957
37.344
−13.766
1.00
21.46
B
C


ATOM
9535
OE1
GLN
B
80
71.283
37.519
−12.744
1.00
24.61
B
O


ATOM
9536
NE2
GLN
B
80
71.702
37.966
−14.903
1.00
18.12
B
N


ATOM
9539
C
GLN
B
80
74.244
33.713
−16.339
1.00
21.60
B
C


ATOM
9540
O
GLN
B
80
73.655
32.624
−16.426
1.00
23.34
B
O


ATOM
9542
N
ARG
B
81
74.930
34.258
−17.340
1.00
19.85
B
N


ATOM
9543
CA
ARG
B
81
75.018
33.618
−18.651
1.00
21.31
B
C


ATOM
9545
CB
ARG
B
81
75.744
34.528
−19.651
1.00
22.39
B
C


ATOM
9548
CG
ARG
B
81
74.902
35.779
−19.950
1.00
24.93
B
C


ATOM
9551
CD
ARG
B
81
75.364
36.514
−21.183
1.00
27.95
B
C


ATOM
9554
NE
ARG
B
81
75.370
35.628
−22.346
1.00
33.40
B
N


ATOM
9556
CZ
ARG
B
81
75.597
36.035
−23.594
1.00
44.92
B
C


ATOM
9557
NH1
ARG
B
81
75.801
37.326
−23.849
1.00
43.90
B
N


ATOM
9560
NH2
ARG
B
81
75.593
35.149
−24.597
1.00
41.12
B
N


ATOM
9563
C
ARG
B
81
75.669
32.256
−18.590
1.00
20.24
B
C


ATOM
9564
O
ARG
B
81
75.228
31.322
−19.268
1.00
23.90
B
O


ATOM
9566
N
LEU
B
82
76.683
32.119
−17.747
1.00
18.56
B
N


ATOM
9567
CA
LEU
B
82
77.374
30.837
−17.558
1.00
17.31
B
C


ATOM
9569
CB
LEU
B
82
78.723
31.056
−16.857
1.00
17.11
B
C


ATOM
9572
CG
LEU
B
82
79.810
31.804
−17.660
1.00
23.24
B
C


ATOM
9574
CD1
LEU
B
82
80.870
32.349
−16.695
1.00
14.65
B
C


ATOM
9578
CD2
LEU
B
82
80.450
30.919
−18.756
1.00
16.24
B
C


ATOM
9582
C
LEU
B
82
76.546
29.833
−16.757
1.00
16.56
B
C


ATOM
9583
O
LEU
B
82
76.966
28.708
−16.571
1.00
17.24
B
O


ATOM
9585
N
GLY
B
83
75.391
30.245
−16.253
1.00
19.51
B
N


ATOM
9586
CA
GLY
B
83
74.459
29.326
−15.600
1.00
20.32
B
C


ATOM
9589
C
GLY
B
83
74.479
29.334
−14.085
1.00
21.68
B
C


ATOM
9590
O
GLY
B
83
73.823
28.495
−13.459
1.00
24.50
B
O


ATOM
9592
N
LEU
B
84
75.188
30.288
−13.480
1.00
21.90
B
N


ATOM
9593
CA
LEU
B
84
75.440
30.252
−12.043
1.00
23.56
B
C


ATOM
9595
CB
LEU
B
84
76.918
30.462
−11.762
1.00
21.53
B
C


ATOM
9598
CG
LEU
B
84
77.914
29.392
−12.227
1.00
22.51
B
C


ATOM
9600
CD1
LEU
B
84
79.332
30.012
−12.350
1.00
17.35
B
C


ATOM
9604
CD2
LEU
B
84
77.936
28.211
−11.274
1.00
14.52
B
C


ATOM
9608
C
LEU
B
84
74.614
31.286
−11.267
1.00
24.75
B
C


ATOM
9609
O
LEU
B
84
74.793
31.464
−10.050
1.00
23.23
B
O


ATOM
9611
N
GLY
B
85
73.704
31.946
−11.957
1.00
20.07
B
N


ATOM
9612
CA
GLY
B
85
72.905
32.986
−11.331
1.00
23.42
B
C


ATOM
9615
C
GLY
B
85
72.103
32.548
−10.128
1.00
23.55
B
C


ATOM
9616
O
GLY
B
85
72.051
33.276
−9.129
1.00
24.14
B
O


ATOM
9618
N
TYR
B
86
71.493
31.358
−10.216
1.00
25.41
B
N


ATOM
9619
CA
TYR
B
86
70.653
30.780
−9.138
1.00
24.89
B
C


ATOM
9621
CB
TYR
B
86
70.088
29.405
−9.555
1.00
23.46
B
C


ATOM
9624
CG
TYR
B
86
71.098
28.272
−9.477
1.00
20.27
B
C


ATOM
9625
CD1
TYR
B
86
71.113
27.378
−8.409
1.00
18.85
B
C


ATOM
9627
CE1
TYR
B
86
72.051
26.334
−8.361
1.00
21.28
B
C


ATOM
9629
CZ
TYR
B
86
72.972
26.173
−9.391
1.00
21.08
B
C


ATOM
9630
OH
TYR
B
86
73.936
25.171
−9.372
1.00
14.76
B
O


ATOM
9632
CE2
TYR
B
86
72.949
27.035
−10.447
1.00
15.78
B
C


ATOM
9634
CD2
TYR
B
86
72.029
28.084
−10.477
1.00
18.71
B
C


ATOM
9636
C
TYR
B
86
71.418
30.580
−7.843
1.00
27.93
B
C


ATOM
9637
O
TYR
B
86
70.847
30.313
−6.788
1.00
29.61
B
O


ATOM
9639
N
ARG
B
87
72.730
30.655
−7.953
1.00
27.91
B
N


ATOM
9640
CA
ARG
B
87
73.620
30.275
−6.899
1.00
27.88
B
C


ATOM
9642
CB
ARG
B
87
74.812
29.611
−7.587
1.00
30.15
B
C


ATOM
9645
CG
ARG
B
87
75.709
28.864
−6.734
1.00
30.85
B
C


ATOM
9648
CD
ARG
B
87
76.316
27.640
−7.442
1.00
29.13
B
C


ATOM
9651
NE
ARG
B
87
76.612
26.804
−6.332
1.00
26.20
B
N


ATOM
9653
CZ
ARG
B
87
75.932
25.744
−5.944
1.00
24.61
B
C


ATOM
9654
NH1
ARG
B
87
76.289
25.177
−4.803
1.00
36.76
B
N


ATOM
9657
NH2
ARG
B
87
74.970
25.210
−6.680
1.00
26.43
B
N


ATOM
9660
C
ARG
B
87
74.038
31.512
−6.147
1.00
27.03
B
C


ATOM
9661
O
ARG
B
87
74.506
31.421
−5.028
1.00
25.59
B
O


ATOM
9663
N
PHE
B
88
73.855
32.679
−6.776
1.00
28.24
B
N


ATOM
9664
CA
PHE
B
88
74.438
33.940
−6.297
1.00
28.26
B
C


ATOM
9666
CB
PHE
B
88
75.605
34.341
−7.210
1.00
25.39
B
C


ATOM
9669
CG
PHE
B
88
76.807
33.456
−7.079
1.00
25.44
B
C


ATOM
9670
CD1
PHE
B
88
77.569
33.468
−5.924
1.00
18.49
B
C


ATOM
9672
CE1
PHE
B
88
78.678
32.671
−5.811
1.00
25.00
B
C


ATOM
9674
CZ
PHE
B
88
79.048
31.820
−6.862
1.00
22.42
B
C


ATOM
9676
CE2
PHE
B
88
78.292
31.788
−8.000
1.00
19.97
B
C


ATOM
9678
CD2
PHE
B
88
77.180
32.609
−8.112
1.00
21.12
B
C


ATOM
9680
C
PHE
B
88
73.404
35.074
−6.240
1.00
29.32
B
C


ATOM
9681
O
PHE
B
88
73.756
36.270
−6.250
1.00
29.34
B
O


ATOM
9683
N
GLU
B
89
72.140
34.695
−6.141
1.00
29.21
B
N


ATOM
9684
CA
GLU
B
89
71.049
35.650
−6.224
1.00
32.70
B
C


ATOM
9686
CB
GLU
B
89
69.701
34.937
−6.103
1.00
33.74
B
C


ATOM
9689
CG
GLU
B
89
68.512
35.887
−6.195
1.00
45.69
B
C


ATOM
9692
CD
GLU
B
89
67.208
35.206
−6.586
1.00
55.76
B
C


ATOM
9693
OE1
GLU
B
89
67.250
34.124
−7.225
1.00
57.29
B
O


ATOM
9694
OE2
GLU
B
89
66.142
35.787
−6.272
1.00
58.91
B
O


ATOM
9695
C
GLU
B
89
71.156
36.755
−5.186
1.00
31.50
B
C


ATOM
9696
O
GLU
B
89
71.011
37.913
−5.516
1.00
33.00
B
O


ATOM
9698
N
SER
B
90
71.421
36.425
−3.935
1.00
31.61
B
N


ATOM
9699
CA
SER
B
90
71.404
37.470
−2.907
1.00
31.80
B
C


ATOM
9701
CB
SER
B
90
71.315
36.860
−1.490
1.00
32.58
B
C


ATOM
9704
OG
SER
B
90
72.570
36.431
−0.986
1.00
41.51
B
O


ATOM
9706
C
SER
B
90
72.600
38.420
−3.061
1.00
29.63
B
C


ATOM
9707
O
SER
B
90
72.524
39.599
−2.730
1.00
30.79
B
O


ATOM
9709
N
ASP
B
91
73.707
37.902
−3.576
1.00
26.77
B
N


ATOM
9710
CA
ASP
B
91
74.889
38.721
−3.783
1.00
24.01
B
C


ATOM
9712
CB
ASP
B
91
76.103
37.821
−4.010
1.00
25.50
B
C


ATOM
9715
CG
ASP
B
91
76.251
36.765
−2.909
1.00
26.74
B
C


ATOM
9716
OD1
ASP
B
91
76.655
37.118
−1.779
1.00
29.64
B
O


ATOM
9717
OD2
ASP
B
91
75.922
35.587
−3.167
1.00
39.56
B
O


ATOM
9718
C
ASP
B
91
74.638
39.638
−4.962
1.00
22.71
B
C


ATOM
9719
O
ASP
B
91
74.987
40.816
−4.931
1.00
19.92
B
O


ATOM
9721
N
ILE
B
92
73.984
39.105
−5.989
1.00
22.65
B
N


ATOM
9722
CA
ILE
B
92
73.661
39.888
−7.185
1.00
22.89
B
C


ATOM
9724
CB
ILE
B
92
73.071
39.000
−8.272
1.00
22.20
B
C


ATOM
9726
CG1
ILE
B
92
74.203
38.179
−8.899
1.00
22.79
B
C


ATOM
9729
CD1
ILE
B
92
73.755
36.921
−9.639
1.00
17.50
B
C


ATOM
9733
CG2
ILE
B
92
72.332
39.853
−9.316
1.00
20.85
B
C


ATOM
9737
C
ILE
B
92
72.710
41.049
−6.869
1.00
24.13
B
C


ATOM
9738
O
ILE
B
92
72.974
42.200
−7.246
1.00
22.72
B
O


ATOM
9740
N
ARG
B
93
71.624
40.744
−6.167
1.00
24.93
B
N


ATOM
9741
CA
ARG
B
93
70.659
41.766
−5.731
1.00
27.69
B
C


ATOM
9743
CB
ARG
B
93
69.522
41.150
−4.895
1.00
29.92
B
C


ATOM
9746
CG
ARG
B
93
68.573
40.217
−5.631
1.00
32.70
B
C


ATOM
9749
CD
ARG
B
93
67.427
39.746
−4.685
1.00
39.32
B
C


ATOM
9752
NE
ARG
B
93
66.650
40.894
−4.231
1.00
40.88
B
N


ATOM
9754
CZ
ARG
B
93
65.793
41.575
−4.993
1.00
47.67
B
C


ATOM
9755
NH1
ARG
B
93
65.565
41.216
−6.262
1.00
47.75
B
N


ATOM
9758
NH2
ARG
B
93
65.147
42.622
−4.484
1.00
51.17
B
N


ATOM
9761
C
ARG
B
93
71.322
42.797
−4.865
1.00
26.85
B
C


ATOM
9762
O
ARG
B
93
71.039
43.980
−4.983
1.00
28.19
B
O


ATOM
9764
N
GLY
B
94
72.186
42.340
−3.966
1.00
26.87
B
N


ATOM
9765
CA
GLY
B
94
72.934
43.248
−3.122
1.00
27.08
B
C


ATOM
9768
C
GLY
B
94
73.776
44.208
−3.939
1.00
27.51
B
C


ATOM
9769
O
GLY
B
94
73.809
45.401
−3.656
1.00
31.87
B
O


ATOM
9771
N
ALA
B
95
74.464
43.704
−4.957
1.00
25.26
B
N


ATOM
9772
CA
ALA
B
95
75.283
44.564
−5.793
1.00
23.60
B
C


ATOM
9774
CB
ALA
B
95
76.133
43.743
−6.728
1.00
21.73
B
C


ATOM
9778
C
ALA
B
95
74.397
45.521
−6.578
1.00
23.80
B
C


ATOM
9779
O
ALA
B
95
74.670
46.712
−6.666
1.00
23.61
B
O


ATOM
9781
N
LEU
B
96
73.322
45.005
−7.152
1.00
25.22
B
N


ATOM
9782
CA
LEU
B
96
72.452
45.858
−7.955
1.00
26.19
B
C


ATOM
9784
CB
LEU
B
96
71.359
45.040
−8.659
1.00
25.27
B
C


ATOM
9787
CG
LEU
B
96
71.931
44.096
−9.719
1.00
26.21
B
C


ATOM
9789
CD1
LEU
B
96
70.839
43.152
−10.263
1.00
20.34
B
C


ATOM
9793
CD2
LEU
B
96
72.591
44.898
−10.840
1.00
19.97
B
C


ATOM
9797
C
LEU
B
96
71.855
46.943
−7.070
1.00
27.60
B
C


ATOM
9798
O
LEU
B
96
71.741
48.080
−7.486
1.00
25.32
B
O


ATOM
9800
N
ASP
B
97
71.510
46.589
−5.834
1.00
30.71
B
N


ATOM
9801
CA
ASP
B
97
70.894
47.534
−4.922
1.00
34.41
B
C


ATOM
9803
CB
ASP
B
97
70.407
46.810
−3.668
1.00
36.18
B
C


ATOM
9806
CG
ASP
B
97
69.603
47.704
−2.770
1.00
46.19
B
C


ATOM
9807
OD1
ASP
B
97
70.026
47.902
−1.611
1.00
56.68
B
O


ATOM
9808
OD2
ASP
B
97
68.567
48.239
−3.235
1.00
53.71
B
O


ATOM
9809
C
ASP
B
97
71.855
48.672
−4.568
1.00
35.18
B
C


ATOM
9810
O
ASP
B
97
71.452
49.829
−4.438
1.00
35.44
B
O


ATOM
9812
N
ARG
B
98
73.128
48.328
−4.428
1.00
37.40
B
N


ATOM
9813
CA
ARG
B
98
74.183
49.305
−4.148
1.00
38.06
B
C


ATOM
9815
CB
ARG
B
98
75.536
48.601
−3.947
1.00
39.12
B
C


ATOM
9818
CG
ARG
B
98
76.260
48.876
−2.626
1.00
41.93
B
C


ATOM
9821
CD
ARG
B
98
76.328
47.616
−1.786
1.00
44.63
B
C


ATOM
9824
NE
ARG
B
98
77.027
46.541
−2.495
1.00
40.39
B
N


ATOM
9826
CZ
ARG
B
98
76.878
45.243
−2.248
1.00
33.84
B
C


ATOM
9827
NH1
ARG
B
98
76.044
44.819
−1.303
1.00
38.65
B
N


ATOM
9830
NH2
ARG
B
98
77.564
44.360
−2.963
1.00
35.04
B
N


ATOM
9833
C
ARG
B
98
74.298
50.240
−5.337
1.00
37.03
B
C


ATOM
9834
O
ARG
B
98
74.388
51.452
−5.189
1.00
35.80
B
O


ATOM
9836
N
PHE
B
99
74.289
49.641
−6.522
1.00
36.87
B
N


ATOM
9837
CA
PHE
B
99
74.457
50.365
−7.767
1.00
36.19
B
C


ATOM
9839
CB
PHE
B
99
74.402
49.380
−8.927
1.00
36.62
B
C


ATOM
9842
CG
PHE
B
99
74.636
49.997
−10.260
1.00
33.49
B
C


ATOM
9843
CD1
PHE
B
99
75.826
50.641
−10.534
1.00
38.87
B
C


ATOM
9845
CE1
PHE
B
99
76.054
51.211
−11.773
1.00
37.59
B
C


ATOM
9847
CZ
PHE
B
99
75.087
51.116
−12.749
1.00
36.98
B
C


ATOM
9849
CE2
PHE
B
99
73.901
50.457
−12.486
1.00
29.58
B
C


ATOM
9851
CD2
PHE
B
99
73.677
49.916
−11.252
1.00
33.52
B
C


ATOM
9853
C
PHE
B
99
73.396
51.431
−7.953
1.00
36.68
B
C


ATOM
9854
O
PHE
B
99
73.686
52.516
−8.465
1.00
37.64
B
O


ATOM
9856
N
VAL
B
100
72.170
51.134
−7.540
1.00
36.30
B
N


ATOM
9857
CA
VAL
B
100
71.102
52.123
−7.615
1.00
38.42
B
C


ATOM
9859
CB
VAL
B
100
69.704
51.479
−7.546
1.00
39.36
B
C


ATOM
9861
CG1
VAL
B
100
68.625
52.555
−7.520
1.00
38.06
B
C


ATOM
9865
CG2
VAL
B
100
69.486
50.541
−8.738
1.00
35.08
B
C


ATOM
9869
C
VAL
B
100
71.258
53.138
−6.489
1.00
40.92
B
C


ATOM
9870
O
VAL
B
100
71.400
54.336
−6.745
1.00
41.13
B
O


ATOM
9872
N
SER
B
101
71.261
52.643
−5.251
1.00
42.85
B
N


ATOM
9873
CA
SER
B
101
71.290
53.499
−4.056
1.00
44.85
B
C


ATOM
9875
CB
SER
B
101
71.364
52.641
−2.783
1.00
45.99
B
C


ATOM
9878
OG
SER
B
101
72.670
52.116
−2.592
1.00
48.88
B
O


ATOM
9880
C
SER
B
101
72.435
54.514
−4.026
1.00
44.67
B
C


ATOM
9881
O
SER
B
101
72.314
55.554
−3.390
1.00
45.09
B
O


ATOM
9883
N
SER
B
102
73.546
54.195
−4.685
1.00
44.99
B
N


ATOM
9884
CA
SER
B
102
74.709
55.078
−4.710
1.00
45.30
B
C


ATOM
9886
CB
SER
B
102
76.001
54.249
−4.754
1.00
45.54
B
C


ATOM
9889
OG
SER
B
102
76.305
53.829
−6.074
1.00
46.99
B
O


ATOM
9891
C
SER
B
102
74.680
56.051
−5.892
1.00
44.38
B
C


ATOM
9892
O
SER
B
102
75.651
56.748
−6.133
1.00
44.36
B
O


ATOM
9894
N
GLY
B
103
73.579
56.086
−6.632
1.00
45.09
B
N


ATOM
9895
CA
GLY
B
103
73.474
56.931
−7.820
1.00
46.00
B
C


ATOM
9898
C
GLY
B
103
74.299
56.453
−9.007
1.00
45.92
B
C


ATOM
9899
O
GLY
B
103
74.416
57.159
−10.016
1.00
45.89
B
O


ATOM
9901
N
GLY
B
104
74.861
55.251
−8.900
1.00
45.67
B
N


ATOM
9902
CA
GLY
B
104
75.678
54.681
−9.965
1.00
45.47
B
C


ATOM
9905
C
GLY
B
104
74.878
54.459
−11.234
1.00
45.06
B
C


ATOM
9906
O
GLY
B
104
75.402
54.617
−12.343
1.00
46.05
B
O


ATOM
9908
N
PHE
B
105
73.603
54.114
−11.074
1.00
43.92
B
N


ATOM
9909
CA
PHE
B
105
72.735
53.885
−12.220
1.00
44.36
B
C


ATOM
9911
CB
PHE
B
105
71.423
53.191
−11.814
1.00
42.94
B
C


ATOM
9914
CG
PHE
B
105
70.454
53.021
−12.957
1.00
42.37
B
C


ATOM
9915
CD1
PHE
B
105
70.829
52.332
−14.103
1.00
36.91
B
C


ATOM
9917
CE1
PHE
B
105
69.952
52.182
−15.166
1.00
37.47
B
C


ATOM
9919
CZ
PHE
B
105
68.680
52.719
−15.094
1.00
41.23
B
C


ATOM
9921
CE2
PHE
B
105
68.291
53.412
−13.959
1.00
42.58
B
C


ATOM
9923
CD2
PHE
B
105
69.178
53.564
−12.897
1.00
44.83
B
C


ATOM
9925
C
PHE
B
105
72.459
55.200
−12.938
1.00
45.55
B
C


ATOM
9926
O
PHE
B
105
72.515
55.272
−14.165
1.00
46.03
B
O


ATOM
9928
N
ASP
B
106
72.181
56.251
−12.184
1.00
48.32
B
N


ATOM
9929
CA
ASP
B
106
71.949
57.544
−12.816
1.00
50.02
B
C


ATOM
9931
CB
ASP
B
106
71.521
58.609
−11.799
1.00
51.66
B
C


ATOM
9934
CG
ASP
B
106
70.532
59.608
−12.389
1.00
59.23
B
C


ATOM
9935
OD1
ASP
B
106
70.967
60.722
−12.764
1.00
68.92
B
O


ATOM
9936
OD2
ASP
B
106
69.329
59.265
−12.503
1.00
64.95
B
O


ATOM
9937
C
ASP
B
106
73.202
57.974
−13.594
1.00
48.61
B
C


ATOM
9938
O
ASP
B
106
73.086
58.477
−14.710
1.00
49.31
B
O


ATOM
9940
N
ALA
B
107
74.384
57.740
−13.017
1.00
46.79
B
N


ATOM
9941
CA
ALA
B
107
75.666
58.062
−13.663
1.00
45.20
B
C


ATOM
9943
CB
ALA
B
107
76.843
57.556
−12.813
1.00
45.79
B
C


ATOM
9947
C
ALA
B
107
75.773
57.487
−15.070
1.00
44.20
B
C


ATOM
9948
O
ALA
B
107
76.122
58.209
−16.012
1.00
43.29
B
O


ATOM
9950
N
VAL
B
108
75.468
56.193
−15.214
1.00
42.78
B
N


ATOM
9951
CA
VAL
B
108
75.678
55.509
−16.490
1.00
41.56
B
C


ATOM
9953
CB
VAL
B
108
75.580
53.961
−16.398
1.00
42.67
B
C


ATOM
9955
CG1
VAL
B
108
76.575
53.424
−15.362
1.00
47.74
B
C


ATOM
9959
CG2
VAL
B
108
74.146
53.506
−16.103
1.00
37.79
B
C


ATOM
9963
C
VAL
B
108
74.736
56.019
−17.565
1.00
40.56
B
C


ATOM
9964
O
VAL
B
108
75.140
56.108
−18.716
1.00
41.01
B
O


ATOM
9966
N
THR
B
109
73.502
56.372
−17.201
1.00
40.25
B
N


ATOM
9967
CA
THR
B
109
72.547
56.895
−18.191
1.00
41.97
B
C


ATOM
9969
CB
THR
B
109
71.113
57.091
−17.604
1.00
41.78
B
C


ATOM
9971
OG1
THR
B
109
71.096
58.187
−16.682
1.00
41.41
B
O


ATOM
9973
CG2
THR
B
109
70.628
55.818
−16.897
1.00
40.99
B
C


ATOM
9977
C
THR
B
109
73.024
58.197
−18.874
1.00
43.11
B
C


ATOM
9978
O
THR
B
109
72.439
58.614
−19.887
1.00
42.41
B
O


ATOM
9980
N
LYS
B
110
74.077
58.819
−18.328
1.00
44.55
B
N


ATOM
9981
CA
LYS
B
110
74.712
60.008
−18.934
1.00
46.75
B
C


ATOM
9983
CB
LYS
B
110
75.089
61.044
−17.862
1.00
47.58
B
C


ATOM
9986
CG
LYS
B
110
74.109
61.209
−16.687
1.00
52.76
B
C


ATOM
9989
CD
LYS
B
110
72.754
61.764
−17.101
1.00
59.40
B
C


ATOM
9992
CE
LYS
B
110
71.958
62.222
−15.878
1.00
63.05
B
C


ATOM
9995
NZ
LYS
B
110
70.552
62.553
−16.225
1.00
62.78
B
N


ATOM
9999
C
LYS
B
110
75.976
59.657
−19.743
1.00
46.76
B
C


ATOM
10000
O
LYS
B
110
76.282
60.317
−20.748
1.00
47.35
B
O


ATOM
10002
N
THR
B
111
76.697
58.619
−19.304
1.00
46.07
B
N


ATOM
10003
CA
THR
B
111
77.998
58.251
−19.878
1.00
44.96
B
C


ATOM
10005
CB
THR
B
111
79.002
57.862
−18.753
1.00
46.02
B
C


ATOM
10007
OG1
THR
B
111
78.445
56.851
−17.896
1.00
46.80
B
O


ATOM
10009
CG2
THR
B
111
79.355
59.091
−17.907
1.00
48.57
B
C


ATOM
10013
C
THR
B
111
77.980
57.145
−20.961
1.00
43.55
B
C


ATOM
10014
O
THR
B
111
78.579
57.326
−22.031
1.00
43.45
B
O


ATOM
10016
N
SER
B
112
77.288
56.026
−20.695
1.00
40.85
B
N


ATOM
10017
CA
SER
B
112
77.475
54.771
−21.460
1.00
38.21
B
C


ATOM
10019
CB
SER
B
112
78.367
53.817
−20.654
1.00
38.70
B
C


ATOM
10022
OG
SER
B
112
78.963
52.840
−21.489
1.00
42.04
B
O


ATOM
10024
C
SER
B
112
76.191
54.013
−21.850
1.00
35.38
B
C


ATOM
10025
O
SER
B
112
75.380
53.635
−20.990
1.00
33.95
B
O


ATOM
10027
N
LEU
B
113
76.039
53.751
−23.146
1.00
32.47
B
N


ATOM
10028
CA
LEU
B
113
74.920
52.960
−23.647
1.00
30.72
B
C


ATOM
10030
CB
LEU
B
113
74.878
52.958
−25.174
1.00
30.16
B
C


ATOM
10033
CG
LEU
B
113
73.792
52.095
−25.831
1.00
29.63
B
C


ATOM
10035
CD1
LEU
B
113
72.399
52.493
−25.368
1.00
27.97
B
C


ATOM
10039
CD2
LEU
B
113
73.891
52.182
−27.341
1.00
34.38
B
C


ATOM
10043
C
LEU
B
113
75.025
51.529
−23.144
1.00
30.25
B
C


ATOM
10044
O
LEU
B
113
74.071
51.011
−22.567
1.00
29.96
B
O


ATOM
10046
N
HIS
B
114
76.182
50.901
−23.371
1.00
29.63
B
N


ATOM
10047
CA
HIS
B
114
76.423
49.536
−22.917
1.00
29.61
B
C


ATOM
10049
CB
HIS
B
114
77.874
49.098
−23.189
1.00
28.64
B
C


ATOM
10052
CG
HIS
B
114
78.237
47.786
−22.557
1.00
30.75
B
C


ATOM
10053
ND1
HIS
B
114
77.483
46.642
−22.722
1.00
32.60
B
N


ATOM
10055
CE1
HIS
B
114
78.039
45.648
−22.048
1.00
36.57
B
C


ATOM
10057
NE2
HIS
B
114
79.126
46.105
−21.449
1.00
37.27
B
N


ATOM
10059
CD2
HIS
B
114
79.271
47.439
−21.750
1.00
36.73
B
C


ATOM
10061
C
HIS
B
114
76.095
49.445
−21.426
1.00
28.21
B
C


ATOM
10062
O
HIS
B
114
75.330
48.587
−21.002
1.00
24.16
B
O


ATOM
10064
N
GLY
B
115
76.666
50.363
−20.651
1.00
26.67
B
N


ATOM
10065
CA
GLY
B
115
76.454
50.389
−19.215
1.00
25.56
B
C


ATOM
10068
C
GLY
B
115
74.993
50.506
−18.845
1.00
25.02
B
C


ATOM
10069
O
GLY
B
115
74.544
49.881
−17.891
1.00
25.22
B
O


ATOM
10071
N
THR
B
116
74.255
51.327
−19.585
1.00
24.92
B
N


ATOM
10072
CA
THR
B
116
72.854
51.580
−19.282
1.00
23.97
B
C


ATOM
10074
CB
THR
B
116
72.386
52.889
−19.917
1.00
24.60
B
C


ATOM
10076
OG1
THR
B
116
73.118
53.974
−19.331
1.00
30.58
B
O


ATOM
10078
CG2
THR
B
116
70.907
53.144
−19.699
1.00
21.02
B
C


ATOM
10082
C
THR
B
116
72.002
50.387
−19.711
1.00
26.00
B
C


ATOM
10083
O
THR
B
116
71.102
49.976
−18.967
1.00
27.03
B
O


ATOM
10085
N
ALA
B
117
72.304
49.799
−20.868
1.00
25.43
B
N


ATOM
10086
CA
ALA
B
117
71.505
48.662
−21.378
1.00
25.89
B
C


ATOM
10088
CB
ALA
B
117
71.933
48.268
−22.811
1.00
24.62
B
C


ATOM
10092
C
ALA
B
117
71.643
47.470
−20.448
1.00
24.68
B
C


ATOM
10093
O
ALA
B
117
70.652
46.837
−20.047
1.00
24.91
B
O


ATOM
10095
N
LEU
B
118
72.883
47.160
−20.117
1.00
23.09
B
N


ATOM
10096
CA
LEU
B
118
73.178
46.044
−19.230
1.00
23.36
B
C


ATOM
10098
CB
LEU
B
118
74.686
45.887
−19.068
1.00
23.58
B
C


ATOM
10101
CG
LEU
B
118
75.181
44.714
−18.231
1.00
26.99
B
C


ATOM
10103
CD1
LEU
B
118
74.478
43.412
−18.671
1.00
21.92
B
C


ATOM
10107
CD2
LEU
B
118
76.708
44.613
−18.322
1.00
19.81
B
C


ATOM
10111
C
LEU
B
118
72.521
46.257
−17.880
1.00
22.07
B
C


ATOM
10112
O
LEU
B
118
71.777
45.405
−17.412
1.00
21.86
B
O


ATOM
10114
N
SER
B
119
72.753
47.417
−17.273
1.00
23.56
B
N


ATOM
10115
CA
SER
B
119
72.214
47.677
−15.938
1.00
23.71
B
C


ATOM
10117
CB
SER
B
119
72.787
48.959
−15.318
1.00
25.08
B
C


ATOM
10120
OG
SER
B
119
72.384
50.147
−15.974
1.00
25.85
B
O


ATOM
10122
C
SER
B
119
70.697
47.691
−15.957
1.00
22.91
B
C


ATOM
10123
O
SER
B
119
70.050
47.212
−15.017
1.00
23.88
B
O


ATOM
10125
N
PHE
B
120
70.124
48.197
−17.036
1.00
21.99
B
N


ATOM
10126
CA
PHE
B
120
68.674
48.240
−17.144
1.00
22.07
B
C


ATOM
10128
CB
PHE
B
120
68.269
48.927
−18.441
1.00
22.76
B
C


ATOM
10131
CG
PHE
B
120
66.792
48.936
−18.703
1.00
23.93
B
C


ATOM
10132
CD1
PHE
B
120
66.012
50.026
−18.329
1.00
24.72
B
C


ATOM
10134
CE1
PHE
B
120
64.651
50.041
−18.588
1.00
21.87
B
C


ATOM
10136
CZ
PHE
B
120
64.064
48.965
−19.235
1.00
25.59
B
C


ATOM
10138
CE2
PHE
B
120
64.831
47.875
−19.615
1.00
21.43
B
C


ATOM
10140
CD2
PHE
B
120
66.187
47.870
−19.355
1.00
26.77
B
C


ATOM
10142
C
PHE
B
120
68.138
46.820
−17.108
1.00
22.44
B
C


ATOM
10143
O
PHE
B
120
67.232
46.510
−16.330
1.00
23.78
B
O


ATOM
10145
N
ARG
B
121
68.708
45.967
−17.954
1.00
20.63
B
N


ATOM
10146
CA
ARG
B
121
68.315
44.563
−18.023
1.00
22.16
B
C


ATOM
10148
CB
ARG
B
121
69.116
43.838
−19.109
1.00
20.34
B
C


ATOM
10151
CG
ARG
B
121
68.782
42.387
−19.214
1.00
22.78
B
C


ATOM
10154
CD
ARG
B
121
69.278
41.785
−20.511
1.00
23.57
B
C


ATOM
10157
NE
ARG
B
121
70.735
41.705
−20.574
1.00
22.85
B
N


ATOM
10159
CZ
ARG
B
121
71.486
40.804
−19.954
1.00
21.72
B
C


ATOM
10160
NH1
ARG
B
121
70.943
39.879
−19.173
1.00
27.91
B
N


ATOM
10163
NH2
ARG
B
121
72.797
40.835
−20.117
1.00
22.89
B
N


ATOM
10166
C
ARG
B
121
68.467
43.826
−16.691
1.00
20.89
B
C


ATOM
10167
O
ARG
B
121
67.536
43.185
−16.244
1.00
22.14
B
O


ATOM
10169
N
LEU
B
122
69.634
43.918
−16.075
1.00
19.65
B
N


ATOM
10170
CA
LEU
B
122
69.877
43.198
−14.829
1.00
21.62
B
C


ATOM
10172
CB
LEU
B
122
71.342
43.312
−14.409
1.00
19.60
B
C


ATOM
10175
CG
LEU
B
122
72.377
42.726
−15.362
1.00
20.38
B
C


ATOM
10177
CD1
LEU
B
122
73.745
43.081
−14.843
1.00
20.38
B
C


ATOM
10181
CD2
LEU
B
122
72.217
41.193
−15.508
1.00
15.76
B
C


ATOM
10185
C
LEU
B
122
68.947
43.705
−13.710
1.00
22.20
B
C


ATOM
10186
O
LEU
B
122
68.419
42.921
−12.921
1.00
22.69
B
O


ATOM
10188
N
LEU
B
123
68.712
45.009
−13.681
1.00
23.60
B
N


ATOM
10189
CA
LEU
B
123
67.893
45.608
−12.624
1.00
24.18
B
C


ATOM
10191
CB
LEU
B
123
67.931
47.130
−12.701
1.00
21.92
B
C


ATOM
10194
CG
LEU
B
123
69.156
47.757
−12.041
1.00
22.98
B
C


ATOM
10196
CD1
LEU
B
123
69.363
49.223
−12.487
1.00
19.39
B
C


ATOM
10200
CD2
LEU
B
123
68.981
47.662
−10.548
1.00
20.14
B
C


ATOM
10204
C
LEU
B
123
66.466
45.120
−12.738
1.00
23.74
B
C


ATOM
10205
O
LEU
B
123
65.855
44.696
−11.753
1.00
21.87
B
O


ATOM
10207
N
ARG
B
124
65.947
45.176
−13.951
1.00
23.61
B
N


ATOM
10208
CA
ARG
B
124
64.580
44.747
−14.194
1.00
22.51
B
C


ATOM
10210
CB
ARG
B
124
64.101
45.189
−15.566
1.00
21.92
B
C


ATOM
10213
CG
ARG
B
124
62.624
44.861
−15.768
1.00
23.90
B
C


ATOM
10216
CD
ARG
B
124
62.050
45.560
−16.965
1.00
23.86
B
C


ATOM
10219
NE
ARG
B
124
61.591
46.926
−16.676
1.00
24.72
B
N


ATOM
10221
CZ
ARG
B
124
61.083
47.743
−17.601
1.00
24.21
B
C


ATOM
10222
NH1
ARG
B
124
60.998
47.363
−18.872
1.00
21.36
B
N


ATOM
10225
NH2
ARG
B
124
60.671
48.955
−17.265
1.00
25.66
B
N


ATOM
10228
C
ARG
B
124
64.420
43.247
−14.052
1.00
22.28
B
C


ATOM
10229
O
ARG
B
124
63.435
42.768
−13.479
1.00
23.53
B
O


ATOM
10231
N
GLN
B
125
65.389
42.490
−14.549
1.00
23.20
B
N


ATOM
10232
CA
GLN
B
125
65.371
41.051
−14.344
1.00
20.98
B
C


ATOM
10234
CB
GLN
B
125
66.693
40.426
−14.832
1.00
22.19
B
C


ATOM
10237
CG
GLN
B
125
66.800
38.889
−14.619
1.00
17.52
B
C


ATOM
10240
CD
GLN
B
125
68.218
38.364
−14.797
1.00
23.28
B
C


ATOM
10241
OE1
GLN
B
125
69.105
39.069
−15.273
1.00
19.79
B
O


ATOM
10242
NE2
GLN
B
125
68.435
37.121
−14.405
1.00
17.64
B
N


ATOM
10245
C
GLN
B
125
65.164
40.777
−12.847
1.00
23.00
B
C


ATOM
10246
O
GLN
B
125
64.420
39.865
−12.453
1.00
24.90
B
O


ATOM
10248
N
HIS
B
126
65.828
41.561
−12.005
1.00
20.88
B
N


ATOM
10249
CA
HIS
B
126
65.780
41.310
−10.576
1.00
22.19
B
C


ATOM
10251
CB
HIS
B
126
67.179
41.491
−9.966
1.00
22.02
B
C


ATOM
10254
CG
HIS
B
126
68.109
40.381
−10.310
1.00
21.58
B
C


ATOM
10255
ND1
HIS
B
126
68.196
39.230
−9.557
1.00
24.31
B
N


ATOM
10257
CE1
HIS
B
126
69.090
38.425
−10.103
1.00
23.72
B
C


ATOM
10259
NE2
HIS
B
126
69.560
38.997
−11.199
1.00
20.64
B
N


ATOM
10261
CD2
HIS
B
126
68.960
40.218
−11.353
1.00
17.59
B
C


ATOM
10263
C
HIS
B
126
64.742
42.137
−9.829
1.00
23.10
B
C


ATOM
10264
O
HIS
B
126
64.850
42.311
−8.624
1.00
23.65
B
O


ATOM
10266
N
GLY
B
127
63.739
42.655
−10.529
1.00
25.00
B
N


ATOM
10267
CA
GLY
B
127
62.577
43.232
−9.849
1.00
24.96
B
C


ATOM
10270
C
GLY
B
127
62.665
44.712
−9.523
1.00
27.27
B
C


ATOM
10271
O
GLY
B
127
61.701
45.275
−9.007
1.00
31.01
B
O


ATOM
10273
N
PHE
B
128
63.798
45.353
−9.818
1.00
27.09
B
N


ATOM
10274
CA
PHE
B
128
63.946
46.787
−9.589
1.00
27.86
B
C


ATOM
10276
CB
PHE
B
128
65.418
47.218
−9.615
1.00
28.07
B
C


ATOM
10279
CG
PHE
B
128
66.208
46.655
−8.482
1.00
28.18
B
C


ATOM
10280
CD1
PHE
B
128
66.303
47.336
−7.294
1.00
28.13
B
C


ATOM
10282
CE1
PHE
B
128
67.003
46.811
−6.249
1.00
33.20
B
C


ATOM
10284
CZ
PHE
B
128
67.592
45.571
−6.362
1.00
34.73
B
C


ATOM
10286
CE2
PHE
B
128
67.479
44.871
−7.535
1.00
30.35
B
C


ATOM
10288
CD2
PHE
B
128
66.785
45.409
−8.580
1.00
26.88
B
C


ATOM
10290
C
PHE
B
128
63.150
47.567
−10.605
1.00
30.22
B
C


ATOM
10291
O
PHE
B
128
62.932
47.122
−11.725
1.00
30.38
B
O


ATOM
10293
N
GLU
B
129
62.703
48.739
−10.185
1.00
31.72
B
N


ATOM
10294
CA
GLU
B
129
61.883
49.589
−10.999
1.00
32.85
B
C


ATOM
10296
CB
GLU
B
129
60.995
50.460
−10.091
1.00
35.17
B
C


ATOM
10299
CG
GLU
B
129
59.781
51.091
−10.797
1.00
46.55
B
C


ATOM
10302
CD
GLU
B
129
59.293
52.392
−10.153
1.00
59.19
B
C


ATOM
10303
OE1
GLU
B
129
59.590
52.647
−8.963
1.00
62.18
B
O


ATOM
10304
OE2
GLU
B
129
58.598
53.169
−10.850
1.00
66.91
B
O


ATOM
10305
C
GLU
B
129
62.833
50.455
−11.828
1.00
30.85
B
C


ATOM
10306
O
GLU
B
129
63.634
51.200
−11.283
1.00
34.34
B
O


ATOM
10308
N
VAL
B
130
62.773
50.339
−13.140
1.00
28.74
B
N


ATOM
10309
CA
VAL
B
130
63.538
51.222
−14.013
1.00
27.95
B
C


ATOM
10311
CB
VAL
B
130
64.783
50.533
−14.591
1.00
28.89
B
C


ATOM
10313
CG1
VAL
B
130
65.800
50.323
−13.491
1.00
29.52
B
C


ATOM
10317
CG2
VAL
B
130
64.422
49.201
−15.242
1.00
25.33
B
C


ATOM
10321
C
VAL
B
130
62.647
51.707
−15.142
1.00
27.27
B
C


ATOM
10322
O
VAL
B
130
61.695
51.033
−15.506
1.00
26.56
B
O


ATOM
10324
N
SER
B
131
62.969
52.872
−15.692
1.00
27.05
B
N


ATOM
10325
CA
SER
B
131
62.140
53.510
−16.713
1.00
27.56
B
C


ATOM
10327
CB
SER
B
131
61.864
54.978
−16.339
1.00
29.10
B
C


ATOM
10330
OG
SER
B
131
61.318
55.713
−17.434
1.00
34.05
B
O


ATOM
10332
C
SER
B
131
62.871
53.470
−18.031
1.00
26.59
B
C


ATOM
10333
O
SER
B
131
64.091
53.530
−18.056
1.00
27.34
B
O


ATOM
10335
N
GLN
B
132
62.125
53.379
−19.127
1.00
26.19
B
N


ATOM
10336
CA
GLN
B
132
62.718
53.487
−20.450
1.00
26.48
B
C


ATOM
10338
CB
GLN
B
132
61.660
53.267
−21.528
1.00
26.03
B
C


ATOM
10341
CG
GLN
B
132
60.477
54.223
−21.463
1.00
26.99
B
C


ATOM
10344
CD
GLN
B
132
59.623
54.191
−22.711
1.00
29.29
B
C


ATOM
10345
OE1
GLN
B
132
59.822
53.355
−23.602
1.00
27.92
B
O


ATOM
10346
NE2
GLN
B
132
58.662
55.110
−22.787
1.00
28.13
B
N


ATOM
10349
C
GLN
B
132
63.404
54.840
−20.664
1.00
28.30
B
C


ATOM
10350
O
GLN
B
132
64.219
54.978
−21.568
1.00
29.48
B
O


ATOM
10352
N
GLU
B
133
63.073
55.840
−19.846
1.00
30.19
B
N


ATOM
10353
CA
GLU
B
133
63.686
57.179
−19.974
1.00
32.53
B
C


ATOM
10355
CB
GLU
B
133
62.976
58.238
−19.113
1.00
33.08
B
C


ATOM
10358
CG
GLU
B
133
61.500
58.466
−19.448
1.00
38.45
B
C


ATOM
10361
CD
GLU
B
133
61.264
59.001
−20.854
1.00
45.49
B
C


ATOM
10362
OE1
GLU
B
133
62.178
59.632
−21.439
1.00
49.73
B
O


ATOM
10363
OE2
GLU
B
133
60.144
58.798
−21.376
1.00
46.47
B
O


ATOM
10364
C
GLU
B
133
65.155
57.140
−19.609
1.00
31.46
B
C


ATOM
10365
O
GLU
B
133
65.884
58.069
−19.912
1.00
32.50
B
O


ATOM
10367
N
ALA
B
134
65.584
56.061
−18.964
1.00
30.90
B
N


ATOM
10368
CA
ALA
B
134
67.002
55.760
−18.824
1.00
30.86
B
C


ATOM
10370
CB
ALA
B
134
67.185
54.385
−18.224
1.00
28.22
B
C


ATOM
10374
C
ALA
B
134
67.723
55.849
−20.170
1.00
31.89
B
C


ATOM
10375
O
ALA
B
134
68.913
56.107
−20.222
1.00
34.24
B
O


ATOM
10377
N
PHE
B
135
66.997
55.657
−21.261
1.00
33.61
B
N


ATOM
10378
CA
PHE
B
135
67.597
55.727
−22.588
1.00
34.02
B
C


ATOM
10380
CB
PHE
B
135
67.014
54.608
−23.456
1.00
32.07
B
C


ATOM
10383
CG
PHE
B
135
67.399
53.261
−22.980
1.00
28.15
B
C


ATOM
10384
CD1
PHE
B
135
66.564
52.535
−22.159
1.00
26.04
B
C


ATOM
10386
CE1
PHE
B
135
66.955
51.280
−21.677
1.00
24.62
B
C


ATOM
10388
CZ
PHE
B
135
68.188
50.768
−22.013
1.00
27.19
B
C


ATOM
10390
CE2
PHE
B
135
69.039
51.497
−22.821
1.00
28.77
B
C


ATOM
10392
CD2
PHE
B
135
68.648
52.740
−23.294
1.00
30.81
B
C


ATOM
10394
C
PHE
B
135
67.454
57.082
−23.281
1.00
36.30
B
C


ATOM
10395
O
PHE
B
135
67.929
57.245
−24.414
1.00
37.39
B
O


ATOM
10397
N
SER
B
136
66.840
58.058
−22.611
1.00
37.55
B
N


ATOM
10398
CA
SER
B
136
66.566
59.356
−23.244
1.00
38.94
B
C


ATOM
10400
CB
SER
B
136
65.767
60.282
−22.305
1.00
39.41
B
C


ATOM
10403
OG
SER
B
136
66.461
60.527
−21.086
1.00
40.01
B
O


ATOM
10405
C
SER
B
136
67.848
60.047
−23.724
1.00
39.27
B
C


ATOM
10406
O
SER
B
136
67.839
60.721
−24.753
1.00
41.19
B
O


ATOM
10408
N
GLY
B
137
68.949
59.847
−23.010
1.00
38.96
B
N


ATOM
10409
CA
GLY
B
137
70.199
60.526
−23.333
1.00
39.72
B
C


ATOM
10412
C
GLY
B
137
70.897
60.111
−24.622
1.00
39.94
B
C


ATOM
10413
O
GLY
B
137
71.863
60.761
−25.027
1.00
40.11
B
O


ATOM
10415
N
PHE
B
138
70.432
59.038
−25.265
1.00
40.41
B
N


ATOM
10416
CA
PHE
B
138
71.074
58.516
−26.490
1.00
41.42
B
C


ATOM
10418
CB
PHE
B
138
71.367
57.019
−26.332
1.00
40.22
B
C


ATOM
10421
CG
PHE
B
138
72.080
56.695
−25.064
1.00
37.60
B
C


ATOM
10422
CD1
PHE
B
138
73.441
56.898
−24.959
1.00
35.26
B
C


ATOM
10424
CE1
PHE
B
138
74.103
56.628
−23.776
1.00
35.62
B
C


ATOM
10426
CZ
PHE
B
138
73.400
56.170
−22.682
1.00
34.61
B
C


ATOM
10428
CE2
PHE
B
138
72.035
55.974
−22.773
1.00
32.75
B
C


ATOM
10430
CD2
PHE
B
138
71.383
56.235
−23.955
1.00
35.81
B
C


ATOM
10432
C
PHE
B
138
70.254
58.760
−27.758
1.00
43.98
B
C


ATOM
10433
O
PHE
B
138
70.642
58.317
−28.843
1.00
43.19
B
O


ATOM
10435
N
LYS
B
139
69.128
59.460
−27.609
1.00
47.54
B
N


ATOM
10436
CA
LYS
B
139
68.279
59.824
−28.734
1.00
51.04
B
C


ATOM
10438
CB
LYS
B
139
66.799
59.812
−28.322
1.00
51.46
B
C


ATOM
10441
CG
LYS
B
139
66.192
58.391
−28.258
1.00
55.89
B
C


ATOM
10444
CD
LYS
B
139
64.883
58.314
−27.450
1.00
59.90
B
C


ATOM
10447
CE
LYS
B
139
63.667
58.845
−28.219
1.00
63.07
B
C


ATOM
10450
NZ
LYS
B
139
63.073
57.860
−29.172
1.00
58.78
B
N


ATOM
10454
C
LYS
B
139
68.699
61.198
−29.255
1.00
53.29
B
C


ATOM
10455
O
LYS
B
139
68.986
62.106
−28.470
1.00
54.74
B
O


ATOM
10457
N
ASP
B
140
68.743
61.339
−30.579
1.00
55.19
B
N


ATOM
10458
CA
ASP
B
140
69.183
62.580
−31.216
1.00
56.63
B
C


ATOM
10460
CB
ASP
B
140
69.663
62.312
−32.662
1.00
55.93
B
C


ATOM
10463
CG
ASP
B
140
68.528
61.932
−33.627
1.00
54.78
B
C


ATOM
10464
OD1
ASP
B
140
67.331
62.035
−33.273
1.00
48.15
B
O


ATOM
10465
OD2
ASP
B
140
68.847
61.518
−34.763
1.00
51.45
B
O


ATOM
10466
C
ASP
B
140
68.090
63.656
−31.172
1.00
59.23
B
C


ATOM
10467
O
ASP
B
140
67.021
63.456
−30.576
1.00
59.10
B
O


ATOM
10469
N
GLN
B
141
68.385
64.794
−31.803
1.00
62.19
B
N


ATOM
10470
CA
GLN
B
141
67.447
65.918
−31.951
1.00
63.69
B
C


ATOM
10472
CB
GLN
B
141
67.947
66.889
−33.034
1.00
64.14
B
C


ATOM
10475
CG
GLN
B
141
69.332
67.484
−32.792
1.00
67.32
B
C


ATOM
10478
CD
GLN
B
141
69.331
68.608
−31.775
1.00
70.44
B
C


ATOM
10479
OE1
GLN
B
141
68.722
68.506
−30.710
1.00
70.76
B
O


ATOM
10480
NE2
GLN
B
141
70.032
69.686
−32.097
1.00
68.92
B
N


ATOM
10483
C
GLN
B
141
66.032
65.451
−32.314
1.00
63.72
B
C


ATOM
10484
O
GLN
B
141
65.086
65.649
−31.544
1.00
63.99
B
O


ATOM
10486
N
ASN
B
142
65.912
64.804
−33.473
1.00
63.20
B
N


ATOM
10487
CA
ASN
B
142
64.622
64.348
−33.997
1.00
62.48
B
C


ATOM
10489
CB
ASN
B
142
64.795
63.752
−35.399
1.00
62.80
B
C


ATOM
10492
CG
ASN
B
142
65.133
64.801
−36.442
1.00
64.18
B
C


ATOM
10493
OD1
ASN
B
142
64.277
65.195
−37.234
1.00
64.38
B
O


ATOM
10494
ND2
ASN
B
142
66.381
65.261
−36.446
1.00
61.04
B
N


ATOM
10497
C
ASN
B
142
63.913
63.330
−33.100
1.00
61.50
B
C


ATOM
10498
O
ASN
B
142
62.686
63.236
−33.128
1.00
61.52
B
O


ATOM
10500
N
GLY
B
143
64.685
62.579
−32.311
1.00
59.99
B
N


ATOM
10501
CA
GLY
B
143
64.141
61.554
−31.415
1.00
58.60
B
C


ATOM
10504
C
GLY
B
143
64.432
60.122
−31.846
1.00
57.01
B
C


ATOM
10505
O
GLY
B
143
63.800
59.186
−31.353
1.00
57.12
B
O


ATOM
10507
N
ASN
B
144
65.374
59.963
−32.778
1.00
54.93
B
N


ATOM
10508
CA
ASN
B
144
65.892
58.658
−33.197
1.00
52.65
B
C


ATOM
10510
CB
ASN
B
144
66.171
58.636
−34.709
1.00
52.20
B
C


ATOM
10513
CG
ASN
B
144
64.960
59.056
−35.545
1.00
55.56
B
C


ATOM
10514
OD1
ASN
B
144
64.720
60.251
−35.772
1.00
57.00
B
O


ATOM
10515
ND2
ASN
B
144
64.208
58.073
−36.026
1.00
53.61
B
N


ATOM
10518
C
ASN
B
144
67.189
58.393
−32.442
1.00
49.76
B
C


ATOM
10519
O
ASN
B
144
67.842
59.331
−32.005
1.00
48.69
B
O


ATOM
10521
N
PHE
B
145
67.569
57.126
−32.281
1.00
47.64
B
N


ATOM
10522
CA
PHE
B
145
68.855
56.807
−31.638
1.00
44.61
B
C


ATOM
10524
CB
PHE
B
145
69.028
55.293
−31.433
1.00
43.24
B
C


ATOM
10527
CG
PHE
B
145
68.385
54.778
−30.171
1.00
37.63
B
C


ATOM
10528
CD1
PHE
B
145
67.113
54.240
−30.192
1.00
30.84
B
C


ATOM
10530
CE1
PHE
B
145
66.516
53.777
−29.038
1.00
32.98
B
C


ATOM
10532
CZ
PHE
B
145
67.188
53.849
−27.839
1.00
35.80
B
C


ATOM
10534
CE2
PHE
B
145
68.462
54.383
−27.796
1.00
36.24
B
C


ATOM
10536
CD2
PHE
B
145
69.052
54.851
−28.958
1.00
35.52
B
C


ATOM
10538
C
PHE
B
145
70.014
57.381
−32.452
1.00
44.54
B
C


ATOM
10539
O
PHE
B
145
69.957
57.418
−33.679
1.00
43.23
B
O


ATOM
10541
N
LEU
B
146
71.051
57.846
−31.761
1.00
45.81
B
N


ATOM
10542
CA
LEU
B
146
72.210
58.429
−32.429
1.00
47.80
B
C


ATOM
10544
CB
LEU
B
146
73.211
58.969
−31.402
1.00
48.75
B
C


ATOM
10547
CG
LEU
B
146
72.777
60.256
−30.682
1.00
50.65
B
C


ATOM
10549
CD1
LEU
B
146
73.588
60.481
−29.409
1.00
52.76
B
C


ATOM
10553
CD2
LEU
B
146
72.894
61.455
−31.605
1.00
50.35
B
C


ATOM
10557
C
LEU
B
146
72.860
57.390
−33.344
1.00
48.09
B
C


ATOM
10558
O
LEU
B
146
73.014
56.241
−32.960
1.00
47.53
B
O


ATOM
10560
N
GLU
B
147
73.217
57.803
−34.559
1.00
49.06
B
N


ATOM
10561
CA
GLU
B
147
73.758
56.896
−35.582
1.00
49.97
B
C


ATOM
10563
CB
GLU
B
147
73.868
57.627
−36.934
1.00
51.58
B
C


ATOM
10566
CG
GLU
B
147
74.260
56.747
−38.147
1.00
56.44
B
C


ATOM
10569
CD
GLU
B
147
73.083
55.980
−38.761
1.00
62.69
B
C


ATOM
10570
OE1
GLU
B
147
71.979
56.554
−38.876
1.00
64.99
B
O


ATOM
10571
OE2
GLU
B
147
73.267
54.806
−39.153
1.00
66.36
B
O


ATOM
10572
C
GLU
B
147
75.132
56.348
−35.201
1.00
49.04
B
C


ATOM
10573
O
GLU
B
147
75.434
55.185
−35.479
1.00
47.66
B
O


ATOM
10575
N
ASN
B
148
75.961
57.187
−34.579
1.00
48.87
B
N


ATOM
10576
CA
ASN
B
148
77.347
56.814
−34.262
1.00
49.90
B
C


ATOM
10578
CB
ASN
B
148
78.202
58.067
−33.992
1.00
51.02
B
C


ATOM
10581
CG
ASN
B
148
78.031
58.610
−32.576
1.00
56.07
B
C


ATOM
10582
OD1
ASN
B
148
78.936
58.492
−31.742
1.00
61.26
B
O


ATOM
10583
ND2
ASN
B
148
76.868
59.198
−32.297
1.00
58.99
B
N


ATOM
10586
C
ASN
B
148
77.497
55.801
−33.110
1.00
48.73
B
C


ATOM
10587
O
ASN
B
148
78.611
55.402
−32.776
1.00
49.75
B
O


ATOM
10589
N
LEU
B
149
76.382
55.390
−32.507
1.00
47.68
B
N


ATOM
10590
CA
LEU
B
149
76.389
54.305
−31.515
1.00
46.24
B
C


ATOM
10592
CB
LEU
B
149
75.105
54.326
−30.675
1.00
44.68
B
C


ATOM
10595
CG
LEU
B
149
74.933
55.554
−29.764
1.00
43.56
B
C


ATOM
10597
CD1
LEU
B
149
73.479
55.709
−29.326
1.00
39.02
B
C


ATOM
10601
CD2
LEU
B
149
75.853
55.508
−28.553
1.00
40.99
B
C


ATOM
10605
C
LEU
B
149
76.588
52.934
−32.184
1.00
45.14
B
C


ATOM
10606
O
LEU
B
149
77.087
52.003
−31.546
1.00
44.56
B
O


ATOM
10608
N
LYS
B
150
76.239
52.828
−33.470
1.00
43.79
B
N


ATOM
10609
CA
LYS
B
150
76.438
51.593
−34.246
1.00
43.54
B
C


ATOM
10611
CB
LYS
B
150
75.933
51.764
−35.682
1.00
43.61
B
C


ATOM
10614
CG
LYS
B
150
76.894
52.553
−36.587
1.00
46.08
B
C


ATOM
10617
CD
LYS
B
150
76.268
52.898
−37.924
1.00
46.55
B
C


ATOM
10620
CE
LYS
B
150
77.268
53.562
−38.861
1.00
44.81
B
C


ATOM
10623
NZ
LYS
B
150
76.697
53.648
−40.228
1.00
43.17
B
N


ATOM
10627
C
LYS
B
150
77.893
51.098
−34.291
1.00
43.90
B
C


ATOM
10628
O
LYS
B
150
78.127
49.952
−34.663
1.00
43.76
B
O


ATOM
10630
N
GLU
B
151
78.854
51.963
−33.953
1.00
44.36
B
N


ATOM
10631
CA
AGLU
B
151
80.275
51.600
−33.889
0.50
45.03
B
C


ATOM
10632
CA
BGLU
B
151
80.259
51.556
−33.922
0.50
44.55
B
C


ATOM
10635
CB
AGLU
B
151
81.158
52.860
−33.903
0.50
45.31
B
C


ATOM
10636
CB
BGLU
B
151
81.192
52.765
−34.101
0.50
44.49
B
C


ATOM
10641
CG
AGLU
B
151
81.067
53.700
−35.176
0.50
46.10
B
C


ATOM
10642
CG
BGLU
B
151
80.988
53.561
−35.408
0.50
42.68
B
C


ATOM
10647
CD
AGLU
B
151
81.927
54.953
−35.116
0.50
46.35
B
C


ATOM
10648
CD
BGLU
B
151
81.246
52.747
−36.675
0.50
39.43
B
C


ATOM
10649
OE1
AGLU
B
151
82.923
54.965
−34.361
0.50
46.87
B
O


ATOM
10650
OE1
BGLU
B
151
82.082
51.820
−36.641
0.50
33.96
B
O


ATOM
10651
OE2
AGLU
B
151
81.610
55.927
−35.830
0.50
47.69
B
O


ATOM
10652
OE2
BGLU
B
151
80.611
53.048
−37.711
0.50
33.24
B
O


ATOM
10653
C
GLU
B
151
80.593
50.796
−32.629
1.00
44.92
B
C


ATOM
10654
O
GLU
B
151
81.544
50.008
−32.603
1.00
45.51
B
O


ATOM
10656
N
ASP
B
152
79.806
51.022
−31.573
1.00
43.91
B
N


ATOM
10657
CA
ASP
B
152
79.998
50.341
−30.286
1.00
43.25
B
C


ATOM
10659
CB
ASP
B
152
79.682
51.305
−29.129
1.00
42.94
B
C


ATOM
10662
CG
ASP
B
152
80.049
50.733
−27.762
1.00
45.23
B
C


ATOM
10663
OD1
ASP
B
152
80.532
49.581
−27.686
1.00
44.55
B
O


ATOM
10664
OD2
ASP
B
152
79.861
51.449
−26.754
1.00
46.70
B
O


ATOM
10665
C
ASP
B
152
79.118
49.076
−30.217
1.00
42.56
B
C


ATOM
10666
O
ASP
B
152
78.040
49.079
−29.619
1.00
42.14
B
O


ATOM
10668
N
ILE
B
153
79.596
47.994
−30.826
1.00
41.74
B
N


ATOM
10669
CA
ILE
B
153
78.793
46.777
−31.016
1.00
40.19
B
C


ATOM
10671
CB
ILE
B
153
79.541
45.753
−31.887
1.00
41.10
B
C


ATOM
10673
CG1
ILE
B
153
79.823
46.346
−33.276
1.00
43.65
B
C


ATOM
10676
CD1
ILE
B
153
81.312
46.361
−33.649
1.00
51.03
B
C


ATOM
10680
CG2
ILE
B
153
78.717
44.468
−32.025
1.00
37.99
B
C


ATOM
10684
C
ILE
B
153
78.407
46.112
−29.702
1.00
39.38
B
C


ATOM
10685
O
ILE
B
153
77.333
45.532
−29.578
1.00
39.13
B
O


ATOM
10687
N
LYS
B
154
79.306
46.185
−28.732
1.00
38.79
B
N


ATOM
10688
CA
LYS
B
154
79.039
45.739
−27.379
1.00
38.18
B
C


ATOM
10690
CB
LYS
B
154
80.232
46.100
−26.488
1.00
40.20
B
C


ATOM
10693
CG
LYS
B
154
80.401
45.276
−25.243
1.00
45.47
B
C


ATOM
10696
CD
LYS
B
154
81.444
45.920
−24.337
1.00
55.39
B
C


ATOM
10699
CE
LYS
B
154
82.112
44.908
−23.420
1.00
61.69
B
C


ATOM
10702
NZ
LYS
B
154
83.180
44.159
−24.141
1.00
65.48
B
N


ATOM
10706
C
LYS
B
154
77.772
46.418
−26.863
1.00
35.45
B
C


ATOM
10707
O
LYS
B
154
76.867
45.753
−26.351
1.00
34.35
B
O


ATOM
10709
N
ALA
B
155
77.702
47.740
−27.023
1.00
32.93
B
N


ATOM
10710
CA
ALA
B
155
76.556
48.512
−26.536
1.00
30.98
B
C


ATOM
10712
CB
ALA
B
155
76.862
50.001
−26.539
1.00
28.88
B
C


ATOM
10716
C
ALA
B
155
75.300
48.222
−27.344
1.00
30.46
B
C


ATOM
10717
O
ALA
B
155
74.190
48.256
−26.799
1.00
31.94
B
O


ATOM
10719
N
ILE
B
156
75.457
47.925
−28.632
1.00
29.25
B
N


ATOM
10720
CA
ILE
B
156
74.293
47.587
−29.471
1.00
29.09
B
C


ATOM
10722
CB
ILE
B
156
74.595
47.690
−30.966
1.00
28.51
B
C


ATOM
10724
CG1
ILE
B
156
75.094
49.091
−31.310
1.00
31.99
B
C


ATOM
10727
CD1
ILE
B
156
74.186
50.194
−30.831
1.00
34.35
B
C


ATOM
10731
CG2
ILE
B
156
73.331
47.424
−31.791
1.00
32.40
B
C


ATOM
10735
C
ILE
B
156
73.710
46.207
−29.149
1.00
27.53
B
C


ATOM
10736
O
ILE
B
156
72.504
46.040
−29.207
1.00
26.96
B
O


ATOM
10738
N
LEU
B
157
74.557
45.234
−28.806
1.00
26.87
B
N


ATOM
10739
CA
LEU
B
157
74.082
43.932
−28.339
1.00
28.36
B
C


ATOM
10741
CB
LEU
B
157
75.228
42.972
−28.089
1.00
29.14
B
C


ATOM
10744
CG
LEU
B
157
75.829
42.284
−29.298
1.00
33.60
B
C


ATOM
10746
CD1
LEU
B
157
77.039
41.499
−28.814
1.00
34.46
B
C


ATOM
10750
CD2
LEU
B
157
74.802
41.359
−29.938
1.00
34.45
B
C


ATOM
10754
C
LEU
B
157
73.345
44.078
−27.029
1.00
27.60
B
C


ATOM
10755
O
LEU
B
157
72.273
43.506
−26.850
1.00
26.85
B
O


ATOM
10757
N
SER
B
158
73.944
44.835
−26.114
1.00
27.41
B
N


ATOM
10758
CA
SER
B
158
73.348
45.048
−24.804
1.00
28.54
B
C


ATOM
10760
CB
SER
B
158
74.277
45.838
−23.896
1.00
27.73
B
C


ATOM
10763
OG
SER
B
158
75.455
45.098
−23.664
1.00
38.76
B
O


ATOM
10765
C
SER
B
158
72.015
45.762
−24.937
1.00
26.50
B
C


ATOM
10766
O
SER
B
158
71.080
45.412
−24.253
1.00
24.81
B
O


ATOM
10768
N
LEU
B
159
71.927
46.739
−25.835
1.00
25.52
B
N


ATOM
10769
CA
LEU
B
159
70.659
47.441
−26.078
1.00
24.28
B
C


ATOM
10771
CB
LEU
B
159
70.858
48.603
−27.043
1.00
24.65
B
C


ATOM
10774
CG
LEU
B
159
69.626
49.433
−27.397
1.00
24.51
B
C


ATOM
10776
CD1
LEU
B
159
68.956
49.970
−26.131
1.00
18.59
B
C


ATOM
10780
CD2
LEU
B
159
70.046
50.557
−28.350
1.00
23.65
B
C


ATOM
10784
C
LEU
B
159
69.624
46.484
−26.647
1.00
23.61
B
C


ATOM
10785
O
LEU
B
159
68.469
46.488
−26.226
1.00
25.84
B
O


ATOM
10787
N
TYR
B
160
70.046
45.665
−27.602
1.00
21.32
B
N


ATOM
10788
CA
TYR
B
160
69.176
44.661
−28.182
1.00
19.66
B
C


ATOM
10790
CB
TYR
B
160
69.963
43.869
−29.209
1.00
18.24
B
C


ATOM
10793
CG
TYR
B
160
69.268
42.660
−29.777
1.00
17.21
B
C


ATOM
10794
CD1
TYR
B
160
68.354
42.773
−30.807
1.00
23.20
B
C


ATOM
10796
CE1
TYR
B
160
67.735
41.642
−31.345
1.00
27.22
B
C


ATOM
10798
CZ
TYR
B
160
68.049
40.398
−30.847
1.00
27.43
B
C


ATOM
10799
OH
TYR
B
160
67.454
39.267
−31.356
1.00
42.06
B
O


ATOM
10801
CE2
TYR
B
160
68.952
40.273
−29.823
1.00
29.75
B
C


ATOM
10803
CD2
TYR
B
160
69.558
41.398
−29.300
1.00
27.84
B
C


ATOM
10805
C
TYR
B
160
68.611
43.735
−27.102
1.00
21.10
B
C


ATOM
10806
O
TYR
B
160
67.392
43.479
−27.061
1.00
20.13
B
O


ATOM
10808
N
GLU
B
161
69.491
43.246
−26.223
1.00
22.83
B
N


ATOM
10809
CA
GLU
B
161
69.086
42.289
−25.195
1.00
22.44
B
C


ATOM
10811
CB
GLU
B
161
70.292
41.754
−24.422
1.00
22.12
B
C


ATOM
10814
CG
GLU
B
161
71.263
40.919
−25.261
1.00
25.71
B
C


ATOM
10817
CD
GLU
B
161
70.733
39.523
−25.628
1.00
27.66
B
C


ATOM
10818
OE1
GLU
B
161
69.565
39.178
−25.328
1.00
34.19
B
O


ATOM
10819
OE2
GLU
B
161
71.505
38.754
−26.223
1.00
23.37
B
O


ATOM
10820
C
GLU
B
161
68.120
42.947
−24.227
1.00
22.70
B
C


ATOM
10821
O
GLU
B
161
67.144
42.332
−23.790
1.00
23.48
B
O


ATOM
10823
N
ALA
B
162
68.396
44.199
−23.899
1.00
20.82
B
N


ATOM
10824
CA
ALA
B
162
67.568
44.936
−22.974
1.00
21.15
B
C


ATOM
10826
CB
ALA
B
162
68.202
46.260
−22.655
1.00
18.59
B
C


ATOM
10830
C
ALA
B
162
66.170
45.145
−23.528
1.00
22.41
B
C


ATOM
10831
O
ALA
B
162
65.197
45.161
−22.765
1.00
24.55
B
O


ATOM
10833
N
SER
B
163
66.063
45.300
−24.845
1.00
21.15
B
N


ATOM
10834
CA
SER
B
163
64.781
45.630
−25.451
1.00
22.45
B
C


ATOM
10836
CB
SER
B
163
64.925
45.885
−26.971
1.00
22.21
B
C


ATOM
10839
OG
SER
B
163
65.265
44.708
−27.695
1.00
22.00
B
O


ATOM
10841
C
SER
B
163
63.725
44.554
−25.191
1.00
22.67
B
C


ATOM
10842
O
SER
B
163
62.529
44.867
−25.088
1.00
22.75
B
O


ATOM
10844
N
PHE
B
164
64.149
43.297
−25.057
1.00
22.13
B
N


ATOM
10845
CA
PHE
B
164
63.175
42.225
−24.898
1.00
22.96
B
C


ATOM
10847
CB
PHE
B
164
63.789
40.856
−25.224
1.00
22.93
B
C


ATOM
10850
CG
PHE
B
164
64.027
40.683
−26.692
1.00
22.93
B
C


ATOM
10851
CD1
PHE
B
164
63.027
40.169
−27.515
1.00
24.94
B
C


ATOM
10853
CE1
PHE
B
164
63.205
40.072
−28.886
1.00
20.58
B
C


ATOM
10855
CZ
PHE
B
164
64.377
40.516
−29.455
1.00
20.41
B
C


ATOM
10857
CE2
PHE
B
164
65.387
41.073
−28.633
1.00
24.66
B
C


ATOM
10859
CD2
PHE
B
164
65.186
41.171
−27.271
1.00
19.04
B
C


ATOM
10861
C
PHE
B
164
62.492
42.257
−23.547
1.00
22.65
B
C


ATOM
10862
O
PHE
B
164
61.512
41.539
−23.338
1.00
23.15
B
O


ATOM
10864
N
LEU
B
165
62.952
43.122
−22.642
1.00
22.52
B
N


ATOM
10865
CA
LEU
B
165
62.341
43.187
−21.315
1.00
21.55
B
C


ATOM
10867
CB
LEU
B
165
63.392
43.432
−20.237
1.00
23.26
B
C


ATOM
10870
CG
LEU
B
165
64.195
42.197
−19.851
1.00
23.00
B
C


ATOM
10872
CD1
LEU
B
165
65.339
41.953
−20.829
1.00
20.20
B
C


ATOM
10876
CD2
LEU
B
165
64.728
42.347
−18.432
1.00
23.73
B
C


ATOM
10880
C
LEU
B
165
61.258
44.228
−21.256
1.00
22.76
B
C


ATOM
10881
O
LEU
B
165
60.804
44.591
−20.174
1.00
23.40
B
O


ATOM
10883
N
ALA
B
166
60.822
44.692
−22.426
1.00
22.61
B
N


ATOM
10884
CA
ALA
B
166
59.900
45.804
−22.517
1.00
23.27
B
C


ATOM
10886
CB
ALA
B
166
59.693
46.181
−23.973
1.00
21.35
B
C


ATOM
10890
C
ALA
B
166
58.565
45.464
−21.899
1.00
22.57
B
C


ATOM
10891
O
ALA
B
166
58.155
44.325
−21.932
1.00
24.73
B
O


ATOM
10893
N
LEU
B
167
57.906
46.463
−21.338
1.00
23.68
B
N


ATOM
10894
CA
LEU
B
167
56.489
46.397
−21.010
1.00
25.21
B
C


ATOM
10896
CB
LEU
B
167
56.234
47.072
−19.671
1.00
25.95
B
C


ATOM
10899
CG
LEU
B
167
57.098
46.586
−18.506
1.00
29.63
B
C


ATOM
10901
CD1
LEU
B
167
56.644
47.255
−17.228
1.00
27.25
B
C


ATOM
10905
CD2
LEU
B
167
57.012
45.081
−18.375
1.00
25.26
B
C


ATOM
10909
C
LEU
B
167
55.663
47.096
−22.097
1.00
26.22
B
C


ATOM
10910
O
LEU
B
167
56.203
47.772
−22.981
1.00
28.50
B
O


ATOM
10912
N
GLU
B
168
54.352
46.917
−22.039
1.00
26.78
B
N


ATOM
10913
CA
GLU
B
168
53.440
47.650
−22.919
1.00
27.31
B
C


ATOM
10915
CB
GLU
B
168
52.004
47.290
−22.578
1.00
28.21
B
C


ATOM
10918
CG
GLU
B
168
51.505
46.007
−23.166
1.00
35.50
B
C


ATOM
10921
CD
GLU
B
168
49.971
45.971
−23.198
1.00
43.15
B
C


ATOM
10922
OE1
GLU
B
168
49.400
45.294
−22.314
1.00
41.77
B
O


ATOM
10923
OE2
GLU
B
168
49.352
46.633
−24.084
1.00
44.65
B
O


ATOM
10924
C
GLU
B
168
53.584
49.172
−22.760
1.00
25.57
B
C


ATOM
10925
O
GLU
B
168
53.595
49.675
−21.638
1.00
25.79
B
O


ATOM
10927
N
GLY
B
169
53.657
49.887
−23.880
1.00
25.49
B
N


ATOM
10928
CA
GLY
B
169
53.772
51.356
−23.887
1.00
24.53
B
C


ATOM
10931
C
GLY
B
169
55.226
51.835
−23.860
1.00
25.77
B
C


ATOM
10932
O
GLY
B
169
55.504
53.029
−24.003
1.00
25.33
B
O


ATOM
10934
N
GLU
B
170
56.170
50.916
−23.681
1.00
24.26
B
N


ATOM
10935
CA
GLU
B
170
57.563
51.316
−23.691
1.00
24.47
B
C


ATOM
10937
CB
GLU
B
170
58.409
50.390
−22.809
1.00
23.98
B
C


ATOM
10940
CG
GLU
B
170
58.085
50.601
−21.322
1.00
27.09
B
C


ATOM
10943
CD
GLU
B
170
58.979
49.840
−20.370
1.00
32.50
B
C


ATOM
10944
OE1
GLU
B
170
59.047
50.248
−19.187
1.00
33.97
B
O


ATOM
10945
OE2
GLU
B
170
59.600
48.835
−20.791
1.00
33.76
B
O


ATOM
10946
C
GLU
B
170
58.057
51.391
−25.122
1.00
25.33
B
C


ATOM
10947
O
GLU
B
170
58.854
50.580
−25.562
1.00
25.77
B
O


ATOM
10949
N
ASN
B
171
57.583
52.405
−25.838
1.00
25.86
B
N


ATOM
10950
CA
ASN
B
171
57.942
52.584
−27.238
1.00
26.42
B
C


ATOM
10952
CB
ASN
B
171
57.206
53.793
−27.826
1.00
26.53
B
C


ATOM
10955
CG
ASN
B
171
57.401
55.060
−26.997
1.00
32.07
B
C


ATOM
10956
OD1
ASN
B
171
56.890
55.173
−25.877
1.00
29.89
B
O


ATOM
10957
ND2
ASN
B
171
58.153
56.012
−27.539
1.00
28.86
B
N


ATOM
10960
C
ASN
B
171
59.449
52.727
−27.472
1.00
27.85
B
C


ATOM
10961
O
ASN
B
171
59.962
52.316
−28.511
1.00
29.62
B
O


ATOM
10963
N
ILE
B
172
60.163
53.299
−26.512
1.00
28.75
B
N


ATOM
10964
CA
ILE
B
172
61.596
53.523
−26.679
1.00
29.05
B
C


ATOM
10966
CB
ILE
B
172
62.175
54.382
−25.549
1.00
29.12
B
C


ATOM
10968
CG1
ILE
B
172
61.608
55.804
−25.644
1.00
31.03
B
C


ATOM
10971
CD1
ILE
B
172
61.983
56.695
−24.488
1.00
32.54
B
C


ATOM
10975
CG2
ILE
B
172
63.686
54.472
−25.651
1.00
28.63
B
C


ATOM
10979
C
ILE
B
172
62.337
52.200
−26.804
1.00
30.66
B
C


ATOM
10980
O
ILE
B
172
63.244
52.075
−27.629
1.00
32.83
B
O


ATOM
10982
N
LEU
B
173
61.922
51.200
−26.029
1.00
30.45
B
N


ATOM
10983
CA
LEU
B
173
62.542
49.875
−26.103
1.00
28.89
B
C


ATOM
10985
CB
LEU
B
173
62.098
49.006
−24.923
1.00
28.96
B
C


ATOM
10988
CG
LEU
B
173
62.869
49.210
−23.615
1.00
28.06
B
C


ATOM
10990
CD1
LEU
B
173
63.107
50.664
−23.324
1.00
28.03
B
C


ATOM
10994
CD2
LEU
B
173
62.101
48.562
−22.474
1.00
28.74
B
C


ATOM
10998
C
LEU
B
173
62.221
49.191
−27.433
1.00
28.15
B
C


ATOM
10999
O
LEU
B
173
63.094
48.582
−28.049
1.00
29.10
B
O


ATOM
11001
N
ASP
B
174
60.976
49.298
−27.878
1.00
27.45
B
N


ATOM
11002
CA
ASP
B
174
60.586
48.825
−29.222
1.00
28.78
B
C


ATOM
11004
CB
ASP
B
174
59.117
49.152
−29.509
1.00
29.66
B
C


ATOM
11007
CG
ASP
B
174
58.140
48.181
−28.843
1.00
36.16
B
C


ATOM
11008
OD1
ASP
B
174
58.535
47.387
−27.960
1.00
45.20
B
O


ATOM
11009
OD2
ASP
B
174
56.954
48.219
−29.219
1.00
44.48
B
O


ATOM
11010
C
ASP
B
174
61.439
49.465
−30.314
1.00
28.84
B
C


ATOM
11011
O
ASP
B
174
61.879
48.805
−31.254
1.00
30.79
B
O


ATOM
11013
N
GLU
B
175
61.660
50.760
−30.193
1.00
29.80
B
N


ATOM
11014
CA
GLU
B
175
62.492
51.469
−31.151
1.00
30.39
B
C


ATOM
11016
CB
GLU
B
175
62.349
52.977
−30.949
1.00
30.54
B
C


ATOM
11019
CG
GLU
B
175
60.948
53.528
−31.292
1.00
35.87
B
C


ATOM
11022
CD
GLU
B
175
60.612
54.872
−30.601
1.00
42.68
B
C


ATOM
11023
OE1
GLU
B
175
61.530
55.551
−30.070
1.00
40.27
B
O


ATOM
11024
OE2
GLU
B
175
59.413
55.246
−30.602
1.00
43.14
B
O


ATOM
11025
C
GLU
B
175
63.944
51.005
−30.982
1.00
30.18
B
C


ATOM
11026
O
GLU
B
175
64.660
50.798
−31.969
1.00
30.45
B
O


ATOM
11028
N
ALA
B
176
64.359
50.807
−29.732
1.00
28.90
B
N


ATOM
11029
CA
ALA
B
176
65.695
50.272
−29.433
1.00
27.90
B
C


ATOM
11031
CB
ALA
B
176
65.829
49.984
−27.974
1.00
26.60
B
C


ATOM
11035
C
ALA
B
176
65.973
49.011
−30.228
1.00
27.63
B
C


ATOM
11036
O
ALA
B
176
67.037
48.867
−30.823
1.00
27.16
B
O


ATOM
11038
N
LYS
B
177
64.992
48.118
−30.253
1.00
27.87
B
N


ATOM
11039
CA
LYS
B
177
65.143
46.821
−30.902
1.00
27.75
B
C


ATOM
11041
CB
LYS
B
177
63.983
45.879
−30.524
1.00
25.44
B
C


ATOM
11044
CG
LYS
B
177
63.931
44.587
−31.332
1.00
27.36
B
C


ATOM
11047
CD
LYS
B
177
63.211
43.426
−30.638
1.00
31.71
B
C


ATOM
11050
CE
LYS
B
177
61.774
43.731
−30.205
1.00
32.14
B
C


ATOM
11053
NZ
LYS
B
177
61.287
42.780
−29.169
1.00
25.79
B
N


ATOM
11057
C
LYS
B
177
65.251
46.964
−32.419
1.00
29.31
B
C


ATOM
11058
O
LYS
B
177
66.057
46.272
−33.042
1.00
30.76
B
O


ATOM
11060
N
VAL
B
178
64.420
47.828
−33.006
1.00
30.40
B
N


ATOM
11061
CA
VAL
B
178
64.425
48.056
−34.460
1.00
29.52
B
C


ATOM
11063
CB
VAL
B
178
63.367
49.122
−34.909
1.00
29.52
B
C


ATOM
11065
CG1
VAL
B
178
63.644
49.609
−36.351
1.00
27.87
B
C


ATOM
11069
CG2
VAL
B
178
61.941
48.598
−34.790
1.00
27.79
B
C


ATOM
11073
C
VAL
B
178
65.797
48.585
−34.819
1.00
30.34
B
C


ATOM
11074
O
VAL
B
178
66.452
48.101
−35.752
1.00
31.89
B
O


ATOM
11076
N
PHE
B
179
66.229
49.575
−34.047
1.00
30.22
B
N


ATOM
11077
CA
PHE
B
179
67.516
50.223
−34.258
1.00
29.99
B
C


ATOM
11079
CB
PHE
B
179
67.688
51.372
−33.260
1.00
29.89
B
C


ATOM
11082
CG
PHE
B
179
69.056
51.967
−33.262
1.00
29.85
B
C


ATOM
11083
CD1
PHE
B
179
69.476
52.745
−34.322
1.00
30.02
B
C


ATOM
11085
CE1
PHE
B
179
70.743
53.287
−34.335
1.00
30.08
B
C


ATOM
11087
CZ
PHE
B
179
71.607
53.063
−33.276
1.00
31.16
B
C


ATOM
11089
CE2
PHE
B
179
71.207
52.288
−32.215
1.00
32.64
B
C


ATOM
11091
CD2
PHE
B
179
69.929
51.735
−32.213
1.00
31.27
B
C


ATOM
11093
C
PHE
B
179
68.694
49.251
−34.147
1.00
30.91
B
C


ATOM
11094
O
PHE
B
179
69.531
49.183
−35.054
1.00
33.53
B
O


ATOM
11096
N
ALA
B
180
68.763
48.502
−33.049
1.00
29.27
B
N


ATOM
11097
CA
ALA
B
180
69.898
47.602
−32.831
1.00
28.27
B
C


ATOM
11099
CB
ALA
B
180
69.951
47.121
−31.393
1.00
26.03
B
C


ATOM
11103
C
ALA
B
180
69.886
46.429
−33.794
1.00
28.76
B
C


ATOM
11104
O
ALA
B
180
70.928
46.013
−34.264
1.00
30.14
B
O


ATOM
11106
N
ILE
B
181
68.713
45.903
−34.105
1.00
30.72
B
N


ATOM
11107
CA
ILE
B
181
68.621
44.841
−35.108
1.00
32.83
B
C


ATOM
11109
CB
ILE
B
181
67.160
44.382
−35.331
1.00
32.27
B
C


ATOM
11111
CG1
ILE
B
181
66.724
43.407
−34.235
1.00
37.17
B
C


ATOM
11114
CD1
ILE
B
181
65.238
42.897
−34.385
1.00
36.59
B
C


ATOM
11118
CG2
ILE
B
181
66.995
43.703
−36.694
1.00
34.78
B
C


ATOM
11122
C
ILE
B
181
69.217
45.289
−36.452
1.00
34.90
B
C


ATOM
11123
O
ILE
B
181
69.973
44.539
−37.078
1.00
35.81
B
O


ATOM
11125
N
SER
B
182
68.885
46.501
−36.893
1.00
36.36
B
N


ATOM
11126
CA
SER
B
182
69.314
46.952
−38.229
1.00
38.78
B
C


ATOM
11128
CB
SER
B
182
68.701
48.315
−38.607
1.00
38.10
B
C


ATOM
11131
OG
SER
B
182
69.333
49.382
−37.919
1.00
41.06
B
O


ATOM
11133
C
SER
B
182
70.840
46.992
−38.350
1.00
39.40
B
C


ATOM
11134
O
SER
B
182
71.385
46.696
−39.407
1.00
40.69
B
O


ATOM
11136
N
HIS
B
183
71.532
47.334
−37.269
1.00
40.96
B
N


ATOM
11137
CA
HIS
B
183
72.998
47.410
−37.315
1.00
41.22
B
C


ATOM
11139
CB
HIS
B
183
73.503
48.563
−36.448
1.00
40.88
B
C


ATOM
11142
CG
HIS
B
183
73.160
49.899
−37.014
1.00
46.75
B
C


ATOM
11143
ND1
HIS
B
183
72.264
50.757
−36.415
1.00
50.90
B
N


ATOM
11145
CE1
HIS
B
183
72.134
51.840
−37.161
1.00
54.30
B
C


ATOM
11147
NE2
HIS
B
183
72.896
51.704
−38.231
1.00
53.96
B
N


ATOM
11149
CD2
HIS
B
183
73.543
50.495
−38.167
1.00
48.27
B
C


ATOM
11151
C
HIS
B
183
73.703
46.112
−36.955
1.00
40.72
B
C


ATOM
11152
O
HIS
B
183
74.900
46.003
−37.173
1.00
42.77
B
O


ATOM
11154
N
LEU
B
184
72.973
45.128
−36.432
1.00
39.36
B
N


ATOM
11155
CA
LEU
B
184
73.590
43.855
−36.043
1.00
38.20
B
C


ATOM
11157
CB
LEU
B
184
72.887
43.260
−34.811
1.00
36.21
B
C


ATOM
11160
CG
LEU
B
184
73.193
43.912
−33.457
1.00
33.67
B
C


ATOM
11162
CD1
LEU
B
184
72.210
43.448
−32.429
1.00
23.99
B
C


ATOM
11166
CD2
LEU
B
184
74.618
43.608
−33.002
1.00
27.65
B
C


ATOM
11170
C
LEU
B
184
73.628
42.823
−37.179
1.00
40.01
B
C


ATOM
11171
O
LEU
B
184
74.596
42.065
−37.301
1.00
37.78
B
O


ATOM
11173
N
LYS
B
185
72.590
42.763
−38.006
1.00
43.51
B
N


ATOM
11174
CA
LYS
B
185
72.541
41.685
−39.001
1.00
48.61
B
C


ATOM
11176
CB
LYS
B
185
71.099
41.321
−39.391
1.00
49.10
B
C


ATOM
11179
CG
LYS
B
185
70.449
42.148
−40.488
1.00
55.39
B
C


ATOM
11182
CD
LYS
B
185
68.962
41.760
−40.670
1.00
62.71
B
C


ATOM
11185
CE
LYS
B
185
68.785
40.320
−41.201
1.00
66.06
B
C


ATOM
11188
NZ
LYS
B
185
67.354
39.952
−41.448
1.00
65.27
B
N


ATOM
11192
C
LYS
B
185
73.431
41.961
−40.218
1.00
50.99
B
C


ATOM
11193
O
LYS
B
185
73.784
41.040
−40.944
1.00
51.11
B
O


ATOM
11195
N
GLU
B
186
73.828
43.213
−40.403
1.00
54.84
B
N


ATOM
11196
CA
GLU
B
186
74.706
43.569
−41.513
1.00
59.61
B
C


ATOM
11198
CB
GLU
B
186
74.519
45.052
−41.895
1.00
60.90
B
C


ATOM
11201
CG
GLU
B
186
73.110
45.425
−42.369
1.00
64.87
B
C


ATOM
11204
CD
GLU
B
186
72.750
44.835
−43.733
1.00
70.39
B
C


ATOM
11205
OE1
GLU
B
186
73.310
45.292
−44.758
1.00
71.34
B
O


ATOM
11206
OE2
GLU
B
186
71.889
43.925
−43.777
1.00
69.40
B
O


ATOM
11207
C
GLU
B
186
76.197
43.293
−41.233
1.00
60.98
B
C


ATOM
11208
O
GLU
B
186
77.017
43.423
−42.139
1.00
61.95
B
O


ATOM
11210
N
LEU
B
187
76.549
42.907
−40.004
1.00
62.28
B
N


ATOM
11211
CA
LEU
B
187
77.964
42.855
−39.581
1.00
62.62
B
C


ATOM
11213
CB
LEU
B
187
78.078
42.851
−38.054
1.00
61.51
B
C


ATOM
11216
CG
LEU
B
187
77.507
44.076
−37.343
1.00
60.53
B
C


ATOM
11218
CD1
LEU
B
187
77.696
43.951
−35.843
1.00
56.66
B
C


ATOM
11222
CD2
LEU
B
187
78.131
45.375
−37.861
1.00
60.27
B
C


ATOM
11226
C
LEU
B
187
78.736
41.662
−40.143
1.00
64.20
B
C


ATOM
11227
O
LEU
B
187
78.216
40.546
−40.198
1.00
64.08
B
O


ATOM
11229
N
SER
B
188
79.987
41.914
−40.533
1.00
65.99
B
N


ATOM
11230
CA
SER
B
188
80.843
40.903
−41.168
1.00
67.23
B
C


ATOM
11232
CB
SER
B
188
81.579
41.514
−42.370
1.00
67.61
B
C


ATOM
11235
OG
SER
B
188
82.193
40.517
−43.168
1.00
68.97
B
O


ATOM
11237
C
SER
B
188
81.862
40.357
−40.172
1.00
67.24
B
C


ATOM
11238
O
SER
B
188
82.548
41.136
−39.507
1.00
66.19
B
O


ATOM
11240
N
GLU
B
189
81.970
39.026
−40.093
1.00
68.52
B
N


ATOM
11241
CA
GLU
B
189
82.944
38.357
−39.206
1.00
70.09
B
C


ATOM
11243
CB
GLU
B
189
82.912
36.818
−39.372
1.00
70.61
B
C


ATOM
11246
CG
GLU
B
189
84.084
36.079
−38.655
1.00
74.42
B
C


ATOM
11249
CD
GLU
B
189
83.884
34.571
−38.451
1.00
78.48
B
C


ATOM
11250
OE1
GLU
B
189
82.846
34.014
−38.868
1.00
78.02
B
O


ATOM
11251
OE2
GLU
B
189
84.790
33.939
−37.857
1.00
81.03
B
O


ATOM
11252
C
GLU
B
189
84.366
38.869
−39.429
1.00
70.71
B
C


ATOM
11253
O
GLU
B
189
85.214
38.768
−38.538
1.00
69.61
B
O


ATOM
11255
N
GLU
B
190
84.619
39.412
−40.617
1.00
71.86
B
N


ATOM
11256
CA
GLU
B
190
85.936
39.921
−40.967
1.00
73.09
B
C


ATOM
11258
CB
GLU
B
190
86.081
39.953
−42.492
1.00
74.22
B
C


ATOM
11261
CG
GLU
B
190
85.947
38.559
−43.117
1.00
77.50
B
C


ATOM
11264
CD
GLU
B
190
85.806
38.582
−44.623
1.00
80.99
B
C


ATOM
11265
OE1
GLU
B
190
86.833
38.752
−45.309
1.00
81.25
B
O


ATOM
11266
OE2
GLU
B
190
84.674
38.400
−45.121
1.00
84.29
B
O


ATOM
11267
C
GLU
B
190
86.227
41.289
−40.324
1.00
72.73
B
C


ATOM
11268
O
GLU
B
190
87.328
41.505
−39.808
1.00
72.35
B
O


ATOM
11270
N
LYS
B
191
85.246
42.195
−40.334
1.00
72.21
B
N


ATOM
11271
CA
LYS
B
191
85.414
43.512
−39.697
1.00
72.24
B
C


ATOM
11273
CB
LYS
B
191
84.208
44.417
−39.967
1.00
73.12
B
C


ATOM
11276
CG
LYS
B
191
84.121
44.922
−41.378
1.00
78.07
B
C


ATOM
11279
CD
LYS
B
191
82.949
45.868
−41.546
1.00
83.68
B
C


ATOM
11282
CE
LYS
B
191
82.589
46.014
−43.012
1.00
85.64
B
C


ATOM
11285
NZ
LYS
B
191
81.322
46.764
−43.228
1.00
85.74
B
N


ATOM
11289
C
LYS
B
191
85.587
43.362
−38.192
1.00
70.52
B
C


ATOM
11290
O
LYS
B
191
86.656
43.635
−37.640
1.00
69.35
B
O


ATOM
11292
N
ILE
B
192
84.515
42.917
−37.546
1.00
68.76
B
N


ATOM
11293
CA
ILE
B
192
84.498
42.712
−36.102
1.00
67.68
B
C


ATOM
11295
CB
ILE
B
192
83.059
42.833
−35.544
1.00
67.45
B
C


ATOM
11297
CG1
ILE
B
192
82.129
41.758
−36.137
1.00
66.91
B
C


ATOM
11300
CD1
ILE
B
192
80.731
41.750
−35.544
1.00
62.95
B
C


ATOM
11304
CG2
ILE
B
192
82.495
44.217
−35.848
1.00
67.23
B
C


ATOM
11308
C
ILE
B
192
85.101
41.346
−35.781
1.00
66.59
B
C


ATOM
11309
O
ILE
B
192
85.310
40.533
−36.678
1.00
65.89
B
O


ATOM
11311
N
GLY
B
193
85.381
41.092
−34.508
1.00
65.99
B
N


ATOM
11312
CA
GLY
B
193
85.987
39.820
−34.095
1.00
66.09
B
C


ATOM
11315
C
GLY
B
193
85.240
38.558
−34.522
1.00
65.01
B
C


ATOM
11316
O
GLY
B
193
84.047
38.599
−34.838
1.00
65.07
B
O


ATOM
11318
N
LYS
B
194
85.950
37.431
−34.522
1.00
63.20
B
N


ATOM
11319
CA
LYS
B
194
85.349
36.125
−34.810
1.00
61.59
B
C


ATOM
11321
CB
LYS
B
194
86.420
35.045
−35.024
1.00
62.81
B
C


ATOM
11324
CG
LYS
B
194
87.707
35.553
−35.719
1.00
69.11
B
C


ATOM
11327
CD
LYS
B
194
88.577
34.426
−36.265
1.00
73.14
B
C


ATOM
11330
CE
LYS
B
194
89.964
34.937
−36.630
1.00
73.97
B
C


ATOM
11333
NZ
LYS
B
194
90.701
33.974
−37.486
1.00
72.97
B
N


ATOM
11337
C
LYS
B
194
84.449
35.739
−33.642
1.00
58.97
B
C


ATOM
11338
O
LYS
B
194
83.352
35.227
−33.848
1.00
58.12
B
O


ATOM
11340
N
GLU
B
195
84.916
36.004
−32.419
1.00
56.35
B
N


ATOM
11341
CA
GLU
B
195
84.129
35.732
−31.211
1.00
54.87
B
C


ATOM
11343
CB
GLU
B
195
84.997
35.779
−29.942
1.00
55.37
B
C


ATOM
11346
CG
GLU
B
195
85.305
37.173
−29.405
1.00
59.74
B
C


ATOM
11349
CD
GLU
B
195
86.263
37.147
−28.214
1.00
65.81
B
C


ATOM
11350
OE1
GLU
B
195
85.953
37.804
−27.195
1.00
68.11
B
O


ATOM
11351
OE2
GLU
B
195
87.321
36.478
−28.292
1.00
62.87
B
O


ATOM
11352
C
GLU
B
195
82.938
36.687
−31.088
1.00
52.05
B
C


ATOM
11353
O
GLU
B
195
81.881
36.302
−30.569
1.00
51.42
B
O


ATOM
11355
N
LEU
B
196
83.104
37.917
−31.575
1.00
48.06
B
N


ATOM
11356
CA
LEU
B
196
82.024
38.902
−31.518
1.00
44.72
B
C


ATOM
11358
CB
LEU
B
196
82.556
40.327
−31.685
1.00
44.61
B
C


ATOM
11361
CG
LEU
B
196
81.759
41.396
−30.928
1.00
44.98
B
C


ATOM
11363
CD1
LEU
B
196
81.934
41.257
−29.418
1.00
47.04
B
C


ATOM
11367
CD2
LEU
B
196
82.168
42.798
−31.387
1.00
45.98
B
C


ATOM
11371
C
LEU
B
196
80.918
38.607
−32.538
1.00
41.82
B
C


ATOM
11372
O
LEU
B
196
79.750
38.849
−32.256
1.00
40.86
B
O


ATOM
11374
N
ALA
B
197
81.273
38.069
−33.705
1.00
39.07
B
N


ATOM
11375
CA
ALA
B
197
80.260
37.639
−34.679
1.00
37.43
B
C


ATOM
11377
CB
ALA
B
197
80.898
37.300
−36.021
1.00
36.56
B
C


ATOM
11381
C
ALA
B
197
79.487
36.437
−34.146
1.00
36.90
B
C


ATOM
11382
O
ALA
B
197
78.300
36.286
−34.411
1.00
39.21
B
O


ATOM
11384
N
GLU
B
198
80.166
35.574
−33.404
1.00
36.09
B
N


ATOM
11385
CA
GLU
B
198
79.496
34.465
−32.744
1.00
36.69
B
C


ATOM
11387
CB
GLU
B
198
80.519
33.469
−32.174
1.00
38.24
B
C


ATOM
11390
CG
GLU
B
198
81.044
32.504
−33.263
1.00
49.87
B
C


ATOM
11393
CD
GLU
B
198
82.379
31.814
−32.933
1.00
59.13
B
C


ATOM
11394
OE1
GLU
B
198
82.981
32.093
−31.870
1.00
66.73
B
O


ATOM
11395
OE2
GLU
B
198
82.824
30.983
−33.760
1.00
62.01
B
O


ATOM
11396
C
GLU
B
198
78.522
34.985
−31.677
1.00
32.99
B
C


ATOM
11397
O
GLU
B
198
77.413
34.491
−31.592
1.00
34.75
B
O


ATOM
11399
N
GLN
B
199
78.913
36.001
−30.908
1.00
29.51
B
N


ATOM
11400
CA
GLN
B
199
77.997
36.612
−29.945
1.00
29.35
B
C


ATOM
11402
CB
GLN
B
199
78.656
37.722
−29.115
1.00
30.73
B
C


ATOM
11405
CG
GLN
B
199
79.775
37.269
−28.142
1.00
39.02
B
C


ATOM
11408
CD
GLN
B
199
79.280
36.756
−26.781
1.00
51.63
B
C


ATOM
11409
OE1
GLN
B
199
78.074
36.694
−26.513
1.00
54.70
B
O


ATOM
11410
NE2
GLN
B
199
80.229
36.385
−25.912
1.00
48.54
B
N


ATOM
11413
C
GLN
B
199
76.783
37.171
−30.668
1.00
28.02
B
C


ATOM
11414
O
GLN
B
199
75.660
36.876
−30.286
1.00
26.21
B
O


ATOM
11416
N
VAL
B
200
77.008
37.933
−31.739
1.00
27.32
B
N


ATOM
11417
CA
VAL
B
200
75.911
38.572
−32.485
1.00
27.54
B
C


ATOM
11419
CB
VAL
B
200
76.453
39.523
−33.589
1.00
28.36
B
C


ATOM
11421
CG1
VAL
B
200
77.351
40.596
−32.963
1.00
29.95
B
C


ATOM
11425
CG2
VAL
B
200
75.324
40.190
−34.359
1.00
26.02
B
C


ATOM
11429
C
VAL
B
200
74.949
37.540
−33.088
1.00
27.67
B
C


ATOM
11430
O
VAL
B
200
73.738
37.684
−32.976
1.00
26.60
B
O


ATOM
11432
N
ASN
B
201
75.484
36.489
−33.705
1.00
28.51
B
N


ATOM
11433
CA
ASN
B
201
74.636
35.429
−34.266
1.00
29.14
B
C


ATOM
11435
CB
ASN
B
201
75.477
34.473
−35.110
1.00
29.87
B
C


ATOM
11438
CG
ASN
B
201
76.085
35.156
−36.340
1.00
35.29
B
C


ATOM
11439
OD1
ASN
B
201
75.519
36.111
−36.876
1.00
40.73
B
O


ATOM
11440
ND2
ASN
B
201
77.240
34.666
−36.786
1.00
36.68
B
N


ATOM
11443
C
ASN
B
201
73.866
34.654
−33.186
1.00
28.87
B
C


ATOM
11444
O
ASN
B
201
72.728
34.266
−33.380
1.00
30.14
B
O


ATOM
11446
N
HIS
B
202
74.488
34.432
−32.039
1.00
28.36
B
N


ATOM
11447
CA
HIS
B
202
73.802
33.791
−30.935
1.00
27.61
B
C


ATOM
11449
CB
HIS
B
202
74.777
33.640
−29.779
1.00
28.85
B
C


ATOM
11452
CG
HIS
B
202
74.225
32.906
−28.604
1.00
27.09
B
C


ATOM
11453
ND1
HIS
B
202
73.851
31.583
−28.665
1.00
23.27
B
N


ATOM
11455
CE1
HIS
B
202
73.430
31.198
−27.473
1.00
31.18
B
C


ATOM
11457
NE2
HIS
B
202
73.510
32.228
−26.646
1.00
29.63
B
N


ATOM
11459
CD2
HIS
B
202
74.018
33.304
−27.326
1.00
26.11
B
C


ATOM
11461
C
HIS
B
202
72.606
34.649
−30.537
1.00
26.71
B
C


ATOM
11462
O
HIS
B
202
71.478
34.167
−30.448
1.00
26.81
B
O


ATOM
11464
N
ALA
B
203
72.850
35.941
−30.355
1.00
27.12
B
N


ATOM
11465
CA
ALA
B
203
71.799
36.880
−29.978
1.00
26.93
B
C


ATOM
11467
CB
ALA
B
203
72.402
38.252
−29.671
1.00
25.40
B
C


ATOM
11471
C
ALA
B
203
70.689
37.000
−31.026
1.00
28.19
B
C


ATOM
11472
O
ALA
B
203
69.521
37.124
−30.667
1.00
32.01
B
O


ATOM
11474
N
LEU
B
204
71.041
36.991
−32.309
1.00
27.53
B
N


ATOM
11475
CA
LEU
B
204
70.039
37.155
−33.359
1.00
27.75
B
C


ATOM
11477
CB
LEU
B
204
70.657
37.643
−34.688
1.00
28.47
B
C


ATOM
11480
CG
LEU
B
204
71.244
39.070
−34.727
1.00
28.70
B
C


ATOM
11482
CD1
LEU
B
204
71.765
39.386
−36.107
1.00
29.73
B
C


ATOM
11486
CD2
LEU
B
204
70.227
40.118
−34.324
1.00
26.53
B
C


ATOM
11490
C
LEU
B
204
69.259
35.862
−33.570
1.00
28.30
B
C


ATOM
11491
O
LEU
B
204
68.130
35.899
−34.012
1.00
29.24
B
O


ATOM
11493
N
GLU
B
205
69.849
34.721
−33.240
1.00
28.21
B
N


ATOM
11494
CA
GLU
B
205
69.089
33.481
−33.215
1.00
27.87
B
C


ATOM
11496
CB
GLU
B
205
70.020
32.319
−32.906
1.00
27.30
B
C


ATOM
11499
CG
GLU
B
205
69.340
30.975
−32.757
1.00
31.98
B
C


ATOM
11502
CD
GLU
B
205
70.312
29.900
−32.313
1.00
38.53
B
C


ATOM
11503
OE1
GLU
B
205
70.900
30.036
−31.211
1.00
37.57
B
O


ATOM
11504
OE2
GLU
B
205
70.500
28.926
−33.072
1.00
44.27
B
O


ATOM
11505
C
GLU
B
205
67.953
33.579
−32.177
1.00
28.31
B
C


ATOM
11506
O
GLU
B
205
66.799
33.221
−32.455
1.00
28.82
B
O


ATOM
11508
N
LEU
B
206
68.288
34.069
−30.985
1.00
27.57
B
N


ATOM
11509
CA
LEU
B
206
67.320
34.184
−29.894
1.00
26.20
B
C


ATOM
11511
CB
LEU
B
206
66.913
32.791
−29.389
1.00
24.32
B
C


ATOM
11514
CG
LEU
B
206
65.658
32.728
−28.529
1.00
26.26
B
C


ATOM
11516
CD1
LEU
B
206
64.389
33.063
−29.342
1.00
20.27
B
C


ATOM
11520
CD2
LEU
B
206
65.519
31.347
−27.850
1.00
22.33
B
C


ATOM
11524
C
LEU
B
206
67.953
34.958
−28.753
1.00
24.67
B
C


ATOM
11525
O
LEU
B
206
69.042
34.609
−28.322
1.00
25.77
B
O


ATOM
11527
N
PRO
B
207
67.274
35.992
−28.247
1.00
22.87
B
N


ATOM
11528
CA
PRO
B
207
67.814
36.834
−27.206
1.00
22.69
B
C


ATOM
11530
CB
PRO
B
207
66.802
37.980
−27.138
1.00
24.47
B
C


ATOM
11533
CG
PRO
B
207
65.548
37.352
−27.566
1.00
22.66
B
C


ATOM
11536
CD
PRO
B
207
65.953
36.470
−28.679
1.00
24.94
B
C


ATOM
11539
C
PRO
B
207
67.835
36.135
−25.879
1.00
22.68
B
C


ATOM
11540
O
PRO
B
207
67.086
35.181
−25.683
1.00
21.77
B
O


ATOM
11541
N
LEU
B
208
68.661
36.645
−24.967
1.00
23.36
B
N


ATOM
11542
CA
LEU
B
208
68.863
36.031
−23.652
1.00
22.82
B
C


ATOM
11544
CB
LEU
B
208
69.783
36.906
−22.799
1.00
26.09
B
C


ATOM
11547
CG
LEU
B
208
71.296
36.760
−22.912
1.00
29.62
B
C


ATOM
11549
CD1
LEU
B
208
71.965
37.877
−22.134
1.00
35.38
B
C


ATOM
11553
CD2
LEU
B
208
71.688
35.403
−22.345
1.00
31.33
B
C


ATOM
11557
C
LEU
B
208
67.554
35.893
−22.915
1.00
22.27
B
C


ATOM
11558
O
LEU
B
208
67.304
34.901
−22.272
1.00
23.52
B
O


ATOM
11560
N
HIS
B
209
66.710
36.912
−23.010
1.00
19.79
B
N


ATOM
11561
CA
HIS
B
209
65.496
36.918
−22.232
1.00
19.81
B
C


ATOM
11563
CB
HIS
B
209
64.819
38.278
−22.387
1.00
18.57
B
C


ATOM
11566
CG
HIS
B
209
63.665
38.491
−21.464
1.00
20.89
B
C


ATOM
11567
ND1
HIS
B
209
63.798
38.455
−20.095
1.00
18.30
B
N


ATOM
11569
CE1
HIS
B
209
62.624
38.687
−19.537
1.00
19.90
B
C


ATOM
11571
NE2
HIS
B
209
61.732
38.865
−20.497
1.00
24.74
B
N


ATOM
11573
CD2
HIS
B
209
62.357
38.745
−21.713
1.00
19.23
B
C


ATOM
11575
C
HIS
B
209
64.550
35.775
−22.659
1.00
18.96
B
C


ATOM
11576
O
HIS
B
209
63.638
35.417
−21.928
1.00
20.40
B
O


ATOM
11578
N
ARG
B
210
64.771
35.214
−23.838
1.00
17.53
B
N


ATOM
11579
CA
ARG
B
210
63.921
34.159
−24.339
1.00
21.00
B
C


ATOM
11581
CB
ARG
B
210
63.417
34.519
−25.736
1.00
21.58
B
C


ATOM
11584
CG
ARG
B
210
62.558
35.776
−25.720
1.00
25.30
B
C


ATOM
11587
CD
ARG
B
210
61.972
36.079
−27.098
1.00
26.92
B
C


ATOM
11590
NE
ARG
B
210
61.038
37.199
−27.044
1.00
26.04
B
N


ATOM
11592
CZ
ARG
B
210
60.373
37.677
−28.089
1.00
25.39
B
C


ATOM
11593
NH1
ARG
B
210
60.529
37.128
−29.286
1.00
28.28
B
N


ATOM
11596
NH2
ARG
B
210
59.530
38.704
−27.933
1.00
26.88
B
N


ATOM
11599
C
ARG
B
210
64.564
32.786
−24.362
1.00
21.01
B
C


ATOM
11600
O
ARG
B
210
63.852
31.814
−24.500
1.00
22.57
B
O


ATOM
11602
N
ARG
B
211
65.881
32.694
−24.190
1.00
21.79
B
N


ATOM
11603
CA
ARG
B
211
66.560
31.387
−24.219
1.00
21.96
B
C


ATOM
11605
CB
ARG
B
211
68.017
31.568
−24.607
1.00
20.36
B
C


ATOM
11608
CG
ARG
B
211
68.659
30.320
−25.118
1.00
25.64
B
C


ATOM
11611
CD
ARG
B
211
70.125
30.557
−25.409
1.00
25.18
B
C


ATOM
11614
NE
ARG
B
211
70.339
31.518
−26.488
1.00
22.19
B
N


ATOM
11616
CZ
ARG
B
211
70.325
31.219
−27.789
1.00
31.36
B
C


ATOM
11617
NH1
ARG
B
211
70.100
29.974
−28.203
1.00
32.36
B
N


ATOM
11620
NH2
ARG
B
211
70.545
32.174
−28.692
1.00
31.10
B
N


ATOM
11623
C
ARG
B
211
66.482
30.715
−22.858
1.00
21.08
B
C


ATOM
11624
O
ARG
B
211
66.562
31.380
−21.829
1.00
23.84
B
O


ATOM
11626
N
THR
B
212
66.332
29.401
−22.841
1.00
21.62
B
N


ATOM
11627
CA
THR
B
212
66.258
28.663
−21.584
1.00
22.86
B
C


ATOM
11629
CB
THR
B
212
65.883
27.196
−21.796
1.00
24.07
B
C


ATOM
11631
OG1
THR
B
212
66.761
26.625
−22.770
1.00
31.00
B
O


ATOM
11633
CG2
THR
B
212
64.443
27.050
−22.274
1.00
19.45
B
C


ATOM
11637
C
THR
B
212
67.628
28.725
−20.923
1.00
23.79
B
C


ATOM
11638
O
THR
B
212
68.643
28.997
−21.580
1.00
23.93
B
O


ATOM
11640
N
GLN
B
213
67.656
28.454
−19.630
1.00
23.05
B
N


ATOM
11641
CA
GLN
B
213
68.850
28.713
−18.832
1.00
21.92
B
C


ATOM
11643
CB
GLN
B
213
68.513
28.620
−17.345
1.00
21.12
B
C


ATOM
11646
CG
GLN
B
213
69.466
29.407
−16.398
1.00
26.64
B
C


ATOM
11649
CD
GLN
B
213
70.578
28.551
−15.863
1.00
26.56
B
C


ATOM
11650
OE1
GLN
B
213
70.991
27.565
−16.490
1.00
26.61
B
O


ATOM
11651
NE2
GLN
B
213
71.079
28.915
−14.701
1.00
20.90
B
N


ATOM
11654
C
GLN
B
213
69.985
27.753
−19.202
1.00
20.81
B
C


ATOM
11655
O
GLN
B
213
71.121
28.187
−19.439
1.00
20.28
B
O


ATOM
11657
N
ARG
B
214
69.690
26.457
−19.252
1.00
20.19
B
N


ATOM
11658
CA
ARG
B
214
70.746
25.484
−19.544
1.00
21.47
B
C


ATOM
11660
CB
ARG
B
214
70.290
24.041
−19.386
1.00
21.13
B
C


ATOM
11663
CG
ARG
B
214
69.953
23.656
−17.970
1.00
21.84
B
C


ATOM
11666
CD
ARG
B
214
71.190
23.470
−17.110
1.00
24.31
B
C


ATOM
11669
NE
ARG
B
214
71.582
24.706
−16.457
1.00
25.78
B
N


ATOM
11671
CZ
ARG
B
214
72.655
24.854
−15.693
1.00
23.08
B
C


ATOM
11672
NH1
ARG
B
214
73.481
23.834
−15.486
1.00
23.99
B
N


ATOM
11675
NH2
ARG
B
214
72.915
26.046
−15.155
1.00
19.12
B
N


ATOM
11678
C
ARG
B
214
71.327
25.675
−20.919
1.00
20.24
B
C


ATOM
11679
O
ARG
B
214
72.531
25.534
−21.070
1.00
20.21
B
O


ATOM
11681
N
LEU
B
215
70.506
26.014
−21.910
1.00
19.38
B
N


ATOM
11682
CA
LEU
B
215
71.021
26.177
−23.278
1.00
21.93
B
C


ATOM
11684
CB
LEU
B
215
69.896
26.332
−24.294
1.00
23.52
B
C


ATOM
11687
CG
LEU
B
215
69.313
25.060
−24.892
1.00
32.95
B
C


ATOM
11689
CD1
LEU
B
215
70.415
24.335
−25.695
1.00
29.05
B
C


ATOM
11693
CD2
LEU
B
215
68.102
25.417
−25.789
1.00
29.82
B
C


ATOM
11697
C
LEU
B
215
71.983
27.354
−23.406
1.00
22.32
B
C


ATOM
11698
O
LEU
B
215
73.016
27.231
−24.041
1.00
22.96
B
O


ATOM
11700
N
GLU
B
216
71.631
28.488
−22.806
1.00
23.34
B
N


ATOM
11701
CA
GLU
B
216
72.543
29.621
−22.693
1.00
23.77
B
C


ATOM
11703
CB
GLU
B
216
71.860
30.793
−21.958
1.00
24.84
B
C


ATOM
11706
CG
GLU
B
216
72.711
32.044
−21.844
1.00
26.26
B
C


ATOM
11709
CD
GLU
B
216
73.313
32.494
−23.185
1.00
29.08
B
C


ATOM
11710
OE1
GLU
B
216
72.657
32.349
−24.232
1.00
30.45
B
O


ATOM
11711
OE2
GLU
B
216
74.452
33.006
−23.181
1.00
29.22
B
O


ATOM
11712
C
GLU
B
216
73.815
29.224
−21.940
1.00
23.03
B
C


ATOM
11713
O
GLU
B
216
74.910
29.595
−22.331
1.00
25.15
B
O


ATOM
11715
N
ALA
B
217
73.692
28.461
−20.865
1.00
21.75
B
N


ATOM
11716
CA
ALA
B
217
74.889
28.141
−20.110
1.00
21.54
B
C


ATOM
11718
CB
ALA
B
217
74.557
27.429
−18.817
1.00
18.56
B
C


ATOM
11722
C
ALA
B
217
75.880
27.336
−20.949
1.00
22.53
B
C


ATOM
11723
O
ALA
B
217
77.092
27.634
−20.954
1.00
24.18
B
O


ATOM
11725
N
VAL
B
218
75.380
26.356
−21.693
1.00
24.24
B
N


ATOM
11726
CA
VAL
B
218
76.264
25.447
−22.423
1.00
24.89
B
C


ATOM
11728
CB
VAL
B
218
75.544
24.155
−22.910
1.00
26.35
B
C


ATOM
11730
CG1
VAL
B
218
74.605
24.436
−24.089
1.00
24.54
B
C


ATOM
11734
CG2
VAL
B
218
76.595
23.062
−23.278
1.00
27.94
B
C


ATOM
11738
C
VAL
B
218
76.947
26.169
−23.569
1.00
24.67
B
C


ATOM
11739
O
VAL
B
218
78.083
25.880
−23.877
1.00
26.68
B
O


ATOM
11741
N
TRP
B
219
76.260
27.128
−24.179
1.00
25.65
B
N


ATOM
11742
CA
TRP
B
219
76.875
27.976
−25.199
1.00
24.72
B
C


ATOM
11744
CB
TRP
B
219
75.789
28.722
−25.996
1.00
26.46
B
C


ATOM
11747
CG
TRP
B
219
76.344
29.516
−27.131
1.00
27.34
B
C


ATOM
11748
CD1
TRP
B
219
76.444
29.122
−28.431
1.00
29.10
B
C


ATOM
11750
NE1
TRP
B
219
77.032
30.117
−29.184
1.00
26.04
B
N


ATOM
11752
CE2
TRP
B
219
77.329
31.171
−28.366
1.00
26.96
B
C


ATOM
11753
CD2
TRP
B
219
76.916
30.826
−27.063
1.00
22.98
B
C


ATOM
11754
CE3
TRP
B
219
77.110
31.745
−26.030
1.00
29.02
B
C


ATOM
11756
CZ3
TRP
B
219
77.708
32.965
−26.327
1.00
30.21
B
C


ATOM
11758
CH2
TRP
B
219
78.117
33.273
−27.620
1.00
28.87
B
C


ATOM
11760
CZ2
TRP
B
219
77.937
32.390
−28.657
1.00
32.64
B
C


ATOM
11762
C
TRP
B
219
77.855
28.978
−24.584
1.00
23.76
B
C


ATOM
11763
O
TRP
B
219
78.924
29.224
−25.124
1.00
27.15
B
O


ATOM
11765
N
SER
B
220
77.495
29.574
−23.456
1.00
23.73
B
N


ATOM
11766
CA
SER
B
220
78.330
30.616
−22.874
1.00
23.51
B
C


ATOM
11768
CB
SER
B
220
77.573
31.395
−21.803
1.00
22.98
B
C


ATOM
11771
OG
SER
B
220
76.786
32.384
−22.416
1.00
25.03
B
O


ATOM
11773
C
SER
B
220
79.606
30.054
−22.286
1.00
24.58
B
C


ATOM
11774
O
SER
B
220
80.623
30.723
−22.291
1.00
26.26
B
O


ATOM
11776
N
ILE
B
221
79.542
28.837
−21.755
1.00
24.53
B
N


ATOM
11777
CA
ILE
B
221
80.726
28.191
−21.221
1.00
25.43
B
C


ATOM
11779
CB
ILE
B
221
80.380
26.930
−20.433
1.00
24.62
B
C


ATOM
11781
CG1
ILE
B
221
79.697
27.327
−19.128
1.00
21.02
B
C


ATOM
11784
CD1
ILE
B
221
78.873
26.217
−18.505
1.00
18.22
B
C


ATOM
11788
CG2
ILE
B
221
81.634
26.132
−20.129
1.00
24.19
B
C


ATOM
11792
C
ILE
B
221
81.711
27.866
−22.347
1.00
28.11
B
C


ATOM
11793
O
ILE
B
221
82.907
28.122
−22.224
1.00
25.44
B
O


ATOM
11795
N
GLU
B
222
81.208
27.331
−23.452
1.00
29.17
B
N


ATOM
11796
CA
GLU
B
222
82.064
27.117
−24.612
1.00
30.37
B
C


ATOM
11798
CB
GLU
B
222
81.305
26.393
−25.728
1.00
31.94
B
C


ATOM
11801
CG
GLU
B
222
82.195
25.909
−26.897
1.00
37.68
B
C


ATOM
11804
CD
GLU
B
222
83.413
25.100
−26.431
1.00
40.63
B
C


ATOM
11805
OE1
GLU
B
222
83.347
24.445
−25.362
1.00
46.08
B
O


ATOM
11806
OE2
GLU
B
222
84.437
25.133
−27.136
1.00
49.29
B
O


ATOM
11807
C
GLU
B
222
82.681
28.425
−25.139
1.00
29.60
B
C


ATOM
11808
O
GLU
B
222
83.845
28.445
−25.474
1.00
31.39
B
O


ATOM
11810
N
ALA
B
223
81.917
29.511
−25.198
1.00
29.46
B
N


ATOM
11811
CA
ALA
B
223
82.460
30.794
−25.669
1.00
27.98
B
C


ATOM
11813
CB
ALA
B
223
81.354
31.779
−25.924
1.00
27.66
B
C


ATOM
11817
C
ALA
B
223
83.446
31.378
−24.672
1.00
29.38
B
C


ATOM
11818
O
ALA
B
223
84.539
31.784
−25.049
1.00
30.35
B
O


ATOM
11820
N
TYR
B
224
83.073
31.405
−23.393
1.00
29.56
B
N


ATOM
11821
CA
TYR
B
224
83.948
31.970
−22.364
1.00
28.89
B
C


ATOM
11823
CB
TYR
B
224
83.281
31.910
−20.991
1.00
27.75
B
C


ATOM
11826
CG
TYR
B
224
83.845
32.869
−19.962
1.00
21.93
B
C


ATOM
11827
CD1
TYR
B
224
83.706
34.246
−20.111
1.00
25.72
B
C


ATOM
11829
CE1
TYR
B
224
84.200
35.134
−19.150
1.00
28.65
B
C


ATOM
11831
CZ
TYR
B
224
84.823
34.646
−18.019
1.00
26.53
B
C


ATOM
11832
OH
TYR
B
224
85.322
35.516
−17.065
1.00
31.14
B
O


ATOM
11834
CE2
TYR
B
224
84.959
33.293
−17.849
1.00
24.43
B
C


ATOM
11836
CD2
TYR
B
224
84.464
32.409
−18.827
1.00
24.32
B
C


ATOM
11838
C
TYR
B
224
85.280
31.227
−22.319
1.00
30.12
B
C


ATOM
11839
O
TYR
B
224
86.333
31.827
−22.135
1.00
30.99
B
O


ATOM
11841
N
ARG
B
225
85.220
29.915
−22.486
1.00
31.92
B
N


ATOM
11842
CA
ARG
B
225
86.409
29.069
−22.478
1.00
34.85
B
C


ATOM
11844
CB
ARG
B
225
85.991
27.615
−22.733
1.00
34.71
B
C


ATOM
11847
CG
ARG
B
225
87.030
26.604
−22.328
1.00
41.35
B
C


ATOM
11850
CD
ARG
B
225
86.910
25.349
−23.161
1.00
44.42
B
C


ATOM
11853
NE
ARG
B
225
85.793
24.534
−22.728
1.00
29.27
B
N


ATOM
11855
CZ
ARG
B
225
85.866
23.584
−21.803
1.00
26.94
B
C


ATOM
11856
NH1
ARG
B
225
87.007
23.300
−21.189
1.00
22.41
B
N


ATOM
11859
NH2
ARG
B
225
84.776
22.892
−21.496
1.00
24.98
B
N


ATOM
11862
C
ARG
B
225
87.452
29.515
−23.529
1.00
36.03
B
C


ATOM
11863
O
ARG
B
225
88.644
29.365
−23.320
1.00
34.54
B
O


ATOM
11865
N
LYS
B
226
86.986
30.054
−24.655
1.00
39.58
B
N


ATOM
11866
CA
LYS
B
226
87.860
30.507
−25.732
1.00
41.75
B
C


ATOM
11868
CB
LYS
B
226
87.114
30.457
−27.069
1.00
41.97
B
C


ATOM
11871
CG
LYS
B
226
86.581
29.085
−27.431
1.00
44.77
B
C


ATOM
11874
CD
LYS
B
226
86.073
29.053
−28.870
1.00
49.54
B
C


ATOM
11877
CE
LYS
B
226
85.298
27.780
−29.192
1.00
50.36
B
C


ATOM
11880
NZ
LYS
B
226
83.891
28.078
−29.559
1.00
51.17
B
N


ATOM
11884
C
LYS
B
226
88.421
31.919
−25.534
1.00
43.33
B
C


ATOM
11885
O
LYS
B
226
89.259
32.355
−26.324
1.00
43.89
B
O


ATOM
11887
N
LYS
B
227
87.962
32.642
−24.514
1.00
45.03
B
N


ATOM
11888
CA
LYS
B
227
88.498
33.981
−24.226
1.00
47.42
B
C


ATOM
11890
CB
LYS
B
227
87.508
34.828
−23.413
1.00
47.85
B
C


ATOM
11893
CG
LYS
B
227
86.288
35.318
−24.172
1.00
50.13
B
C


ATOM
11896
CD
LYS
B
227
85.580
36.442
−23.402
1.00
56.73
B
C


ATOM
11899
CE
LYS
B
227
84.102
36.545
−23.774
1.00
64.18
B
C


ATOM
11902
NZ
LYS
B
227
83.858
36.666
−25.249
1.00
66.49
B
N


ATOM
11906
C
LYS
B
227
89.814
33.870
−23.453
1.00
48.79
B
C


ATOM
11907
O
LYS
B
227
89.862
33.243
−22.382
1.00
49.31
B
O


ATOM
11909
N
GLU
B
228
90.873
34.484
−23.987
1.00
48.99
B
N


ATOM
11910
CA
GLU
B
228
92.184
34.472
−23.327
1.00
49.23
B
C


ATOM
11912
CB
GLU
B
228
93.265
35.098
−24.220
1.00
50.17
B
C


ATOM
11915
CG
GLU
B
228
94.651
35.139
−23.556
1.00
56.84
B
C


ATOM
11918
CD
GLU
B
228
95.805
35.113
−24.551
1.00
62.65
B
C


ATOM
11919
OE1
GLU
B
228
95.772
35.883
−25.536
1.00
63.14
B
O


ATOM
11920
OE2
GLU
B
228
96.753
34.324
−24.336
1.00
62.24
B
O


ATOM
11921
C
GLU
B
228
92.150
35.184
−21.972
1.00
46.82
B
C


ATOM
11922
O
GLU
B
228
92.875
34.808
−21.048
1.00
47.31
B
O


ATOM
11924
N
ASP
B
229
91.304
36.202
−21.859
1.00
43.57
B
N


ATOM
11925
CA
ASP
B
229
91.168
36.959
−20.621
1.00
42.02
B
C


ATOM
11927
CB
ASP
B
229
90.946
38.439
−20.943
1.00
43.47
B
C


ATOM
11930
CG
ASP
B
229
89.751
38.661
−21.854
1.00
47.72
B
C


ATOM
11931
OD1
ASP
B
229
89.491
37.784
−22.704
1.00
51.55
B
O


ATOM
11932
OD2
ASP
B
229
89.079
39.704
−21.726
1.00
55.81
B
O


ATOM
11933
C
ASP
B
229
90.035
36.448
−19.714
1.00
38.44
B
C


ATOM
11934
O
ASP
B
229
89.667
37.131
−18.769
1.00
37.66
B
O


ATOM
11936
N
ALA
B
230
89.489
35.261
−19.983
1.00
35.09
B
N


ATOM
11937
CA
ALA
B
230
88.432
34.696
−19.131
1.00
33.38
B
C


ATOM
11939
CB
ALA
B
230
87.915
33.392
−19.704
1.00
33.10
B
C


ATOM
11943
C
ALA
B
230
88.934
34.465
−17.711
1.00
32.12
B
C


ATOM
11944
O
ALA
B
230
90.070
34.048
−17.495
1.00
30.75
B
O


ATOM
11946
N
ASN
B
231
88.080
34.738
−16.736
1.00
30.68
B
N


ATOM
11947
CA
ASN
B
231
88.422
34.453
−15.359
1.00
29.53
B
C


ATOM
11949
CB
ASN
B
231
87.456
35.129
−14.388
1.00
29.88
B
C


ATOM
11952
CG
ASN
B
231
87.820
34.867
−12.947
1.00
33.58
B
C


ATOM
11953
OD1
ASN
B
231
87.935
33.714
−12.520
1.00
31.88
B
O


ATOM
11954
ND2
ASN
B
231
88.032
35.936
−12.189
1.00
42.97
B
N


ATOM
11957
C
ASN
B
231
88.388
32.960
−15.152
1.00
27.93
B
C


ATOM
11958
O
ASN
B
231
87.334
32.338
−15.276
1.00
26.52
B
O


ATOM
11960
N
GLN
B
232
89.539
32.398
−14.806
1.00
27.85
B
N


ATOM
11961
CA
GLN
B
232
89.696
30.945
−14.719
1.00
28.06
B
C


ATOM
11963
CB
GLN
B
232
91.178
30.574
−14.669
1.00
27.87
B
C


ATOM
11966
CG
GLN
B
232
91.958
30.978
−15.931
1.00
33.14
B
C


ATOM
11969
CD
GLN
B
232
91.460
30.284
−17.202
1.00
35.07
B
C


ATOM
11970
OE1
GLN
B
232
91.496
29.059
−17.301
1.00
37.93
B
O


ATOM
11971
NE2
GLN
B
232
91.003
31.069
−18.177
1.00
32.06
B
N


ATOM
11974
C
GLN
B
232
88.940
30.326
−13.538
1.00
27.32
B
C


ATOM
11975
O
GLN
B
232
88.472
29.175
−13.625
1.00
28.40
B
O


ATOM
11977
N
VAL
B
233
88.814
31.081
−12.449
1.00
23.84
B
N


ATOM
11978
CA
VAL
B
233
88.047
30.625
−11.305
1.00
23.03
B
C


ATOM
11980
CB
VAL
B
233
88.182
31.592
−10.105
1.00
23.26
B
C


ATOM
11982
CG1
VAL
B
233
87.102
31.342
−9.096
1.00
19.84
B
C


ATOM
11986
CG2
VAL
B
233
89.581
31.440
−9.438
1.00
25.03
B
C


ATOM
11990
C
VAL
B
233
86.583
30.457
−11.713
1.00
23.81
B
C


ATOM
11991
O
VAL
B
233
85.990
29.405
−11.492
1.00
23.11
B
O


ATOM
11993
N
LEU
B
234
86.014
31.491
−12.330
1.00
22.26
B
N


ATOM
11994
CA
LEU
B
234
84.630
31.454
−12.733
1.00
22.19
B
C


ATOM
11996
CB
LEU
B
234
84.219
32.814
−13.267
1.00
22.77
B
C


ATOM
11999
CG
LEU
B
234
82.774
33.046
−13.690
1.00
21.02
B
C


ATOM
12001
CD1
LEU
B
234
81.821
32.913
−12.510
1.00
13.82
B
C


ATOM
12005
CD2
LEU
B
234
82.673
34.433
−14.302
1.00
18.88
B
C


ATOM
12009
C
LEU
B
234
84.402
30.345
−13.776
1.00
22.30
B
C


ATOM
12010
O
LEU
B
234
83.411
29.637
−13.717
1.00
20.57
B
O


ATOM
12012
N
LEU
B
235
85.344
30.188
−14.702
1.00
22.73
B
N


ATOM
12013
CA
LEU
B
235
85.219
29.215
−15.783
1.00
22.64
B
C


ATOM
12015
CB
LEU
B
235
86.431
29.277
−16.707
1.00
23.38
B
C


ATOM
12018
CG
LEU
B
235
86.482
28.297
−17.885
1.00
26.34
B
C


ATOM
12020
CD1
LEU
B
235
85.223
28.417
−18.756
1.00
16.79
B
C


ATOM
12024
CD2
LEU
B
235
87.756
28.530
−18.717
1.00
19.46
B
C


ATOM
12028
C
LEU
B
235
85.121
27.835
−15.206
1.00
21.21
B
C


ATOM
12029
O
LEU
B
235
84.249
27.054
−15.565
1.00
20.49
B
O


ATOM
12031
N
GLU
B
236
86.038
27.550
−14.301
1.00
22.20
B
N


ATOM
12032
CA
GLU
B
236
86.112
26.249
−13.692
1.00
22.88
B
C


ATOM
12034
CB
GLU
B
236
87.348
26.114
−12.787
1.00
22.27
B
C


ATOM
12037
CG
GLU
B
236
87.471
24.721
−12.224
1.00
25.07
B
C


ATOM
12040
CD
GLU
B
236
88.782
24.458
−11.508
1.00
30.11
B
C


ATOM
12041
OE1
GLU
B
236
89.489
25.432
−11.145
1.00
32.54
B
O


ATOM
12042
OE2
GLU
B
236
89.081
23.254
−11.316
1.00
28.82
B
O


ATOM
12043
C
GLU
B
236
84.852
25.988
−12.902
1.00
21.39
B
C


ATOM
12044
O
GLU
B
236
84.299
24.885
−12.977
1.00
23.11
B
O


ATOM
12046
N
LEU
B
237
84.395
26.989
−12.154
1.00
19.15
B
N


ATOM
12047
CA
LEU
B
237
83.205
26.805
−11.340
1.00
17.76
B
C


ATOM
12049
CB
LEU
B
237
82.892
28.060
−10.548
1.00
15.89
B
C


ATOM
12052
CG
LEU
B
237
81.682
27.946
−9.637
1.00
14.28
B
C


ATOM
12054
CD1
LEU
B
237
81.846
26.791
−8.650
1.00
8.37
B
C


ATOM
12058
CD2
LEU
B
237
81.476
29.262
−8.914
1.00
13.97
B
C


ATOM
12062
C
LEU
B
237
82.035
26.434
−12.255
1.00
18.88
B
C


ATOM
12063
O
LEU
B
237
81.303
25.467
−11.980
1.00
21.48
B
O


ATOM
12065
N
ALA
B
238
81.911
27.163
−13.362
1.00
16.52
B
N


ATOM
12066
CA
ALA
B
238
80.791
27.010
−14.287
1.00
18.32
B
C


ATOM
12068
CB
ALA
B
238
80.871
28.022
−15.404
1.00
16.15
B
C


ATOM
12072
C
ALA
B
238
80.759
25.621
−14.881
1.00
20.18
B
C


ATOM
12073
O
ALA
B
238
79.683
25.009
−14.973
1.00
22.18
B
O


ATOM
12075
N
ILE
B
239
81.932
25.132
−15.293
1.00
19.80
B
N


ATOM
12076
CA
ILE
B
239
82.039
23.792
−15.821
1.00
19.87
B
C


ATOM
12078
CB
ILE
B
239
83.461
23.458
−16.279
1.00
20.01
B
C


ATOM
12080
CG1
ILE
B
239
83.800
24.223
−17.567
1.00
21.51
B
C


ATOM
12083
CD1
ILE
B
239
85.250
23.962
−18.074
1.00
19.39
B
C


ATOM
12087
CG2
ILE
B
239
83.601
21.955
−16.508
1.00
13.60
B
C


ATOM
12091
C
ILE
B
239
81.589
22.800
−14.757
1.00
21.11
B
C


ATOM
12092
O
ILE
B
239
80.781
21.917
−15.030
1.00
22.06
B
O


ATOM
12094
N
LEU
B
240
82.090
22.968
−13.543
1.00
21.72
B
N


ATOM
12095
CA
LEU
B
240
81.820
22.022
−12.474
1.00
23.21
B
C


ATOM
12097
CB
LEU
B
240
82.645
22.326
−11.208
1.00
23.26
B
C


ATOM
12100
CG
LEU
B
240
83.815
21.443
−10.789
1.00
32.42
B
C


ATOM
12102
CD1
LEU
B
240
84.539
20.728
−11.964
1.00
33.31
B
C


ATOM
12106
CD2
LEU
B
240
84.799
22.287
−9.940
1.00
30.31
B
C


ATOM
12110
C
LEU
B
240
80.353
22.027
−12.106
1.00
21.05
B
C


ATOM
12111
O
LEU
B
240
79.753
20.969
−11.972
1.00
23.99
B
O


ATOM
12113
N
ASP
B
241
79.800
23.205
−11.876
1.00
20.47
B
N


ATOM
12114
CA
ASP
B
241
78.395
23.319
−11.512
1.00
20.64
B
C


ATOM
12116
CB
ASP
B
241
78.004
24.779
−11.273
1.00
21.72
B
C


ATOM
12119
CG
ASP
B
241
76.721
24.920
−10.461
1.00
25.74
B
C


ATOM
12120
OD1
ASP
B
241
75.606
24.991
−11.048
1.00
24.61
B
O


ATOM
12121
OD2
ASP
B
241
76.829
24.948
−9.231
1.00
20.16
B
O


ATOM
12122
C
ASP
B
241
77.513
22.698
−12.610
1.00
20.65
B
C


ATOM
12123
O
ASP
B
241
76.609
21.925
−12.306
1.00
20.46
B
O


ATOM
12125
N
TYR
B
242
77.816
22.985
−13.876
1.00
20.03
B
N


ATOM
12126
CA
TYR
B
242
76.993
22.490
−14.981
1.00
21.97
B
C


ATOM
12128
CB
TYR
B
242
77.486
23.024
−16.327
1.00
21.09
B
C


ATOM
12131
CG
TYR
B
242
76.593
22.662
−17.515
1.00
21.48
B
C


ATOM
12132
CD1
TYR
B
242
75.662
23.564
−18.022
1.00
20.87
B
C


ATOM
12134
CE1
TYR
B
242
74.844
23.217
−19.112
1.00
23.37
B
C


ATOM
12136
CZ
TYR
B
242
74.986
21.976
−19.706
1.00
19.51
B
C


ATOM
12137
OH
TYR
B
242
74.216
21.612
−20.777
1.00
27.52
B
O


ATOM
12139
CE2
TYR
B
242
75.914
21.084
−19.226
1.00
19.92
B
C


ATOM
12141
CD2
TYR
B
242
76.702
21.429
−18.138
1.00
21.77
B
C


ATOM
12143
C
TYR
B
242
76.922
20.967
−15.033
1.00
22.49
B
C


ATOM
12144
O
TYR
B
242
75.836
20.393
−15.206
1.00
22.20
B
O


ATOM
12146
N
ASN
B
243
78.082
20.324
−14.937
1.00
22.43
B
N


ATOM
12147
CA
ASN
B
243
78.157
18.857
−14.990
1.00
22.60
B
C


ATOM
12149
CB
ASN
B
243
79.601
18.375
−15.194
1.00
20.63
B
C


ATOM
12152
CG
ASN
B
243
80.153
18.766
−16.560
1.00
25.15
B
C


ATOM
12153
OD1
ASN
B
243
79.389
18.975
−17.507
1.00
28.79
B
O


ATOM
12154
ND2
ASN
B
243
81.478
18.871
−16.670
1.00
18.72
B
N


ATOM
12157
C
ASN
B
243
77.546
18.240
−13.741
1.00
20.99
B
C


ATOM
12158
O
ASN
B
243
76.966
17.154
−13.795
1.00
22.45
B
O


ATOM
12160
N
MET
B
244
77.646
18.942
−12.626
1.00
19.24
B
N


ATOM
12161
CA
MET
B
244
76.979
18.480
−11.426
1.00
22.91
B
C


ATOM
12163
CB
MET
B
244
77.363
19.339
−10.230
1.00
22.09
B
C


ATOM
12166
CG
MET
B
244
76.629
18.976
−8.959
1.00
26.36
B
C


ATOM
12169
SD
MET
B
244
76.675
20.330
−7.774
1.00
40.41
B
S


ATOM
12170
CE
MET
B
244
75.425
21.413
−8.512
1.00
38.87
B
C


ATOM
12174
C
MET
B
244
75.449
18.467
−11.621
1.00
23.24
B
C


ATOM
12175
O
MET
B
244
74.793
17.460
−11.333
1.00
24.26
B
O


ATOM
12177
N
ILE
B
245
74.898
19.569
−12.120
1.00
22.08
B
N


ATOM
12178
CA
ILE
B
245
73.457
19.669
−12.309
1.00
21.64
B
C


ATOM
12180
CB
ILE
B
245
73.036
21.093
−12.702
1.00
22.89
B
C


ATOM
12182
CG1
ILE
B
245
73.240
22.044
−11.518
1.00
22.42
B
C


ATOM
12185
CD1
ILE
B
245
72.776
23.512
−11.793
1.00
23.27
B
C


ATOM
12189
CG2
ILE
B
245
71.558
21.129
−13.161
1.00
20.97
B
C


ATOM
12193
C
ILE
B
245
73.037
18.640
−13.356
1.00
21.34
B
C


ATOM
12194
O
ILE
B
245
72.069
17.912
−13.180
1.00
21.20
B
O


ATOM
12196
N
GLN
B
246
73.803
18.526
−14.423
1.00
21.82
B
N


ATOM
12197
CA
GLN
B
246
73.522
17.493
−15.396
1.00
22.03
B
C


ATOM
12199
CB
GLN
B
246
74.574
17.464
−16.484
1.00
22.15
B
C


ATOM
12202
CG
GLN
B
246
74.215
16.563
−17.638
1.00
21.61
B
C


ATOM
12205
CD
GLN
B
246
75.271
16.560
−18.695
1.00
21.70
B
C


ATOM
12206
OE1
GLN
B
246
76.364
16.058
−18.472
1.00
32.02
B
O


ATOM
12207
NE2
GLN
B
246
74.962
17.133
−19.861
1.00
24.97
B
N


ATOM
12210
C
GLN
B
246
73.417
16.121
−14.743
1.00
24.58
B
C


ATOM
12211
O
GLN
B
246
72.529
15.355
−15.097
1.00
24.66
B
O


ATOM
12213
N
SER
B
247
74.285
15.797
−13.784
1.00
23.32
B
N


ATOM
12214
CA
SER
B
247
74.229
14.455
−13.209
1.00
25.50
B
C


ATOM
12216
CB
SER
B
247
75.468
14.111
−12.354
1.00
24.49
B
C


ATOM
12219
OG
SER
B
247
75.372
14.688
−11.056
1.00
30.70
B
O


ATOM
12221
C
SER
B
247
72.932
14.269
−12.417
1.00
25.70
B
C


ATOM
12222
O
SER
B
247
72.401
13.167
−12.346
1.00
26.49
B
O


ATOM
12224
N
VAL
B
248
72.412
15.338
−11.833
1.00
25.46
B
N


ATOM
12225
CA
VAL
B
248
71.079
15.268
−11.244
1.00
25.37
B
C


ATOM
12227
CB
VAL
B
248
70.708
16.577
−10.534
1.00
25.38
B
C


ATOM
12229
CG1
VAL
B
248
69.289
16.493
−9.982
1.00
21.73
B
C


ATOM
12233
CG2
VAL
B
248
71.737
16.887
−9.411
1.00
21.11
B
C


ATOM
12237
C
VAL
B
248
70.019
14.910
−12.324
1.00
27.50
B
C


ATOM
12238
O
VAL
B
248
69.186
14.022
−12.114
1.00
30.45
B
O


ATOM
12240
N
TYR
B
249
70.069
15.575
−13.475
1.00
25.85
B
N


ATOM
12241
CA
TYR
B
249
69.129
15.288
−14.571
1.00
26.78
B
C


ATOM
12243
CB
TYR
B
249
69.407
16.170
−15.807
1.00
25.46
B
C


ATOM
12246
CG
TYR
B
249
69.297
17.684
−15.619
1.00
24.49
B
C


ATOM
12247
CD1
TYR
B
249
68.579
18.237
−14.570
1.00
19.54
B
C


ATOM
12249
CE1
TYR
B
249
68.456
19.592
−14.429
1.00
21.35
B
C


ATOM
12251
CZ
TYR
B
249
69.059
20.421
−15.335
1.00
23.71
B
C


ATOM
12252
OH
TYR
B
249
68.955
21.768
−15.170
1.00
24.97
B
O


ATOM
12254
CE2
TYR
B
249
69.757
19.909
−16.406
1.00
21.28
B
C


ATOM
12256
CD2
TYR
B
249
69.880
18.553
−16.539
1.00
22.56
B
C


ATOM
12258
C
TYR
B
249
69.190
13.819
−15.025
1.00
28.33
B
C


ATOM
12259
O
TYR
B
249
68.153
13.182
−15.264
1.00
27.41
B
O


ATOM
12261
N
GLN
B
250
70.411
13.317
−15.184
1.00
27.94
B
N


ATOM
12262
CA
GLN
B
250
70.647
11.928
−15.547
1.00
28.73
B
C


ATOM
12264
CB
GLN
B
250
72.140
11.676
−15.770
1.00
28.24
B
C


ATOM
12267
CG
GLN
B
250
72.701
12.430
−16.993
1.00
26.66
B
C


ATOM
12270
CD
GLN
B
250
74.230
12.432
−17.049
1.00
30.68
B
C


ATOM
12271
OE1
GLN
B
250
74.890
12.107
−16.073
1.00
28.92
B
O


ATOM
12272
NE2
GLN
B
250
74.792
12.819
−18.196
1.00
27.40
B
N


ATOM
12275
C
GLN
B
250
70.044
10.973
−14.505
1.00
29.66
B
C


ATOM
12276
O
GLN
B
250
69.393
10.007
−14.868
1.00
30.79
B
O


ATOM
12278
N
ARG
B
251
70.179
11.263
−13.219
1.00
30.47
B
N


ATOM
12279
CA
ARG
B
251
69.458
10.465
−12.218
1.00
31.78
B
C


ATOM
12281
CB
ARG
B
251
69.915
10.799
−10.792
1.00
32.21
B
C


ATOM
12284
CG
ARG
B
251
69.243
9.926
−9.703
1.00
39.99
B
C


ATOM
12287
CD
ARG
B
251
69.850
10.113
−8.314
1.00
51.23
B
C


ATOM
12290
NE
ARG
B
251
70.143
11.526
−8.019
1.00
62.83
B
N


ATOM
12292
CZ
ARG
B
251
71.360
12.091
−7.992
1.00
67.84
B
C


ATOM
12293
NH1
ARG
B
251
72.469
11.384
−8.228
1.00
66.43
B
N


ATOM
12296
NH2
ARG
B
251
71.470
13.391
−7.716
1.00
67.17
B
N


ATOM
12299
C
ARG
B
251
67.914
10.585
−12.351
1.00
31.19
B
C


ATOM
12300
O
ARG
B
251
67.212
9.576
−12.358
1.00
31.09
B
O


ATOM
12302
N
ASP
B
252
67.397
11.806
−12.450
1.00
29.49
B
N


ATOM
12303
CA
ASP
B
252
65.973
12.026
−12.633
1.00
27.24
B
C


ATOM
12305
CB
ASP
B
252
65.686
13.502
−12.947
1.00
28.05
B
C


ATOM
12308
CG
ASP
B
252
66.003
14.474
−11.791
1.00
30.79
B
C


ATOM
12309
OD1
ASP
B
252
66.059
14.063
−10.612
1.00
31.73
B
O


ATOM
12310
OD2
ASP
B
252
66.155
15.691
−12.096
1.00
28.66
B
O


ATOM
12311
C
ASP
B
252
65.474
11.193
−13.831
1.00
28.33
B
C


ATOM
12312
O
ASP
B
252
64.457
10.512
−13.754
1.00
28.67
B
O


ATOM
12314
N
LEU
B
253
66.203
11.267
−14.940
1.00
28.59
B
N


ATOM
12315
CA
LEU
B
253
65.850
10.580
−16.179
1.00
29.23
B
C


ATOM
12317
CB
LEU
B
253
66.735
11.070
−17.332
1.00
26.17
B
C


ATOM
12320
CG
LEU
B
253
66.435
10.484
−18.704
1.00
32.56
B
C


ATOM
12322
CD1
LEU
B
253
64.988
10.790
−19.120
1.00
22.29
B
C


ATOM
12326
CD2
LEU
B
253
67.448
10.988
−19.739
1.00
36.23
B
C


ATOM
12330
C
LEU
B
253
65.945
9.055
−16.093
1.00
30.46
B
C


ATOM
12331
O
LEU
B
253
65.246
8.361
−16.831
1.00
29.74
B
O


ATOM
12333
N
ARG
B
254
66.819
8.537
−15.231
1.00
32.61
B
N


ATOM
12334
CA
ARG
B
254
66.942
7.083
−15.057
1.00
35.04
B
C


ATOM
12336
CB
ARG
B
254
68.241
6.682
−14.330
1.00
36.65
B
C


ATOM
12339
CG
ARG
B
254
69.522
6.685
−15.202
1.00
39.59
B
C


ATOM
12342
CD
ARG
B
254
70.676
5.892
−14.532
1.00
45.23
B
C


ATOM
12345
NE
ARG
B
254
71.001
6.378
−13.184
1.00
43.70
B
N


ATOM
12347
CZ
ARG
B
254
71.747
7.452
−12.921
1.00
44.00
B
C


ATOM
12348
NH1
ARG
B
254
72.276
8.181
−13.910
1.00
39.76
B
N


ATOM
12351
NH2
ARG
B
254
71.961
7.807
−11.659
1.00
43.71
B
N


ATOM
12354
C
ARG
B
254
65.720
6.574
−14.306
1.00
34.86
B
C


ATOM
12355
O
ARG
B
254
65.111
5.593
−14.712
1.00
35.53
B
O


ATOM
12357
N
GLU
B
255
65.346
7.291
−13.251
1.00
34.73
B
N


ATOM
12358
CA
GLU
B
255
64.149
7.011
−12.450
1.00
37.10
B
C


ATOM
12360
CB
GLU
B
255
64.060
8.073
−11.345
1.00
39.63
B
C


ATOM
12363
CG
GLU
B
255
63.692
7.589
−9.941
1.00
52.09
B
C


ATOM
12366
CD
GLU
B
255
64.217
8.541
−8.844
1.00
59.96
B
C


ATOM
12367
OE1
GLU
B
255
65.456
8.703
−8.728
1.00
62.20
B
O


ATOM
12368
OE2
GLU
B
255
63.393
9.120
−8.103
1.00
63.44
B
O


ATOM
12369
C
GLU
B
255
62.851
7.043
−13.298
1.00
37.49
B
C


ATOM
12370
O
GLU
B
255
61.983
6.172
−13.179
1.00
38.24
B
O


ATOM
12372
N
THR
B
256
62.726
8.066
−14.139
1.00
33.48
B
N


ATOM
12373
CA
THR
B
256
61.550
8.236
−14.970
1.00
32.03
B
C


ATOM
12375
CB
THR
B
256
61.489
9.676
−15.484
1.00
28.82
B
C


ATOM
12377
OG1
THR
B
256
61.258
10.518
−14.365
1.00
31.10
B
O


ATOM
12379
CG2
THR
B
256
60.378
9.886
−16.462
1.00
32.38
B
C


ATOM
12383
C
THR
B
256
61.529
7.209
−16.104
1.00
31.37
B
C


ATOM
12384
O
THR
B
256
60.465
6.736
−16.483
1.00
30.12
B
O


ATOM
12386
N
SER
B
257
62.704
6.859
−16.632
1.00
32.20
B
N


ATOM
12387
CA
SER
B
257
62.816
5.812
−17.662
1.00
32.63
B
C


ATOM
12389
CB
SER
B
257
64.257
5.674
−18.156
1.00
32.05
B
C


ATOM
12392
OG
SER
B
257
64.640
6.805
−18.913
1.00
35.00
B
O


ATOM
12394
C
SER
B
257
62.329
4.460
−17.135
1.00
32.30
B
C


ATOM
12395
O
SER
B
257
61.626
3.731
−17.836
1.00
32.52
B
O


ATOM
12397
N
ARG
B
258
62.687
4.150
−15.893
1.00
31.83
B
N


ATOM
12398
CA
ARG
B
258
62.215
2.934
−15.244
1.00
35.46
B
C


ATOM
12400
CB
ARG
B
258
62.737
2.777
−13.798
1.00
37.72
B
C


ATOM
12403
CG
ARG
B
258
64.138
2.136
−13.696
1.00
46.00
B
C


ATOM
12406
CD
ARG
B
258
64.423
1.530
−12.295
1.00
51.03
B
C


ATOM
12409
NE
ARG
B
258
64.165
2.474
−11.198
1.00
52.82
B
N


ATOM
12411
CZ
ARG
B
258
65.033
3.368
−10.717
1.00
56.37
B
C


ATOM
12412
NH1
ARG
B
258
64.663
4.155
−9.715
1.00
57.59
B
N


ATOM
12415
NH2
ARG
B
258
66.261
3.492
−11.219
1.00
58.73
B
N


ATOM
12418
C
ARG
B
258
60.715
2.938
−15.235
1.00
33.44
B
C


ATOM
12419
O
ARG
B
258
60.098
1.963
−15.640
1.00
34.72
B
O


ATOM
12421
N
TRP
B
259
60.132
4.032
−14.773
1.00
31.58
B
N


ATOM
12422
CA
TRP
B
259
58.695
4.182
−14.811
1.00
31.82
B
C


ATOM
12424
CB
TRP
B
259
58.281
5.561
−14.324
1.00
32.08
B
C


ATOM
12427
CG
TRP
B
259
56.866
5.918
−14.621
1.00
27.02
B
C


ATOM
12428
CD1
TRP
B
259
55.764
5.504
−13.935
1.00
30.20
B
C


ATOM
12430
NE1
TRP
B
259
54.632
6.051
−14.491
1.00
34.18
B
N


ATOM
12432
CE2
TRP
B
259
54.991
6.832
−15.558
1.00
25.57
B
C


ATOM
12433
CD2
TRP
B
259
56.394
6.780
−15.666
1.00
26.24
B
C


ATOM
12434
CE3
TRP
B
259
57.015
7.473
−16.706
1.00
21.19
B
C


ATOM
12436
CZ3
TRP
B
259
56.238
8.204
−17.569
1.00
25.68
B
C


ATOM
12438
CH2
TRP
B
259
54.848
8.253
−17.423
1.00
31.07
B
C


ATOM
12440
CZ2
TRP
B
259
54.209
7.562
−16.425
1.00
26.47
B
C


ATOM
12442
C
TRP
B
259
58.158
3.980
−16.222
1.00
31.90
B
C


ATOM
12443
O
TRP
B
259
57.209
3.231
−16.416
1.00
34.40
B
O


ATOM
12445
N
TRP
B
260
58.755
4.650
−17.201
1.00
29.58
B
N


ATOM
12446
CA
TRP
B
260
58.219
4.623
−18.564
1.00
29.21
B
C


ATOM
12448
CB
TRP
B
260
59.020
5.542
−19.471
1.00
28.39
B
C


ATOM
12451
CG
TRP
B
260
58.463
5.760
−20.832
1.00
31.21
B
C


ATOM
12452
CD1
TRP
B
260
59.128
5.613
−22.011
1.00
32.56
B
C


ATOM
12454
NE1
TRP
B
260
58.305
5.952
−23.056
1.00
35.69
B
N


ATOM
12456
CE2
TRP
B
260
57.088
6.341
−22.564
1.00
28.01
B
C


ATOM
12457
CD2
TRP
B
260
57.140
6.220
−21.171
1.00
26.28
B
C


ATOM
12458
CE3
TRP
B
260
56.006
6.556
−20.426
1.00
29.49
B
C


ATOM
12460
CZ3
TRP
B
260
54.871
6.979
−21.092
1.00
27.25
B
C


ATOM
12462
CH2
TRP
B
260
54.851
7.081
−22.477
1.00
26.73
B
C


ATOM
12464
CZ2
TRP
B
260
55.947
6.764
−23.232
1.00
32.88
B
C


ATOM
12466
C
TRP
B
260
58.244
3.226
−19.150
1.00
27.50
B
C


ATOM
12467
O
TRP
B
260
57.308
2.844
−19.832
1.00
23.27
B
O


ATOM
12469
N
ARG
B
261
59.324
2.503
−18.865
1.00
29.60
B
N


ATOM
12470
CA
ARG
B
261
59.551
1.144
−19.348
1.00
34.53
B
C


ATOM
12472
CB
ARG
B
261
60.971
0.697
−18.977
1.00
35.16
B
C


ATOM
12475
CG
ARG
B
261
61.605
−0.290
−19.932
1.00
46.23
B
C


ATOM
12478
CD
ARG
B
261
63.068
−0.626
−19.554
1.00
55.36
B
C


ATOM
12481
NE
ARG
B
261
63.895
0.584
−19.412
1.00
60.95
B
N


ATOM
12483
CZ
ARG
B
261
64.475
1.013
−18.281
1.00
63.65
B
C


ATOM
12484
NH1
ARG
B
261
65.189
2.134
−18.300
1.00
57.86
B
N


ATOM
12487
NH2
ARG
B
261
64.369
0.342
−17.130
1.00
65.79
B
N


ATOM
12490
C
ARG
B
261
58.509
0.198
−18.741
1.00
37.14
B
C


ATOM
12491
O
ARG
B
261
57.920
−0.634
−19.435
1.00
39.01
B
O


ATOM
12493
N
ARG
B
262
58.284
0.360
−17.442
1.00
38.02
B
N


ATOM
12494
CA
ARG
B
262
57.177
−0.268
−16.716
1.00
39.33
B
C


ATOM
12496
CB
ARG
B
262
57.015
0.410
−15.345
1.00
43.52
B
C


ATOM
12499
CG
ARG
B
262
56.465
−0.472
−14.256
1.00
52.63
B
C


ATOM
12502
CD
ARG
B
262
57.576
−1.181
−13.525
1.00
62.09
B
C


ATOM
12505
NE
ARG
B
262
57.050
−2.325
−12.786
1.00
69.73
B
N


ATOM
12507
CZ
ARG
B
262
56.722
−3.494
−13.333
1.00
71.95
B
C


ATOM
12508
NH1
ARG
B
262
56.865
−3.698
−14.642
1.00
69.88
B
N


ATOM
12511
NH2
ARG
B
262
56.243
−4.462
−12.561
1.00
73.11
B
N


ATOM
12514
C
ARG
B
262
55.852
−0.134
−17.434
1.00
34.28
B
C


ATOM
12515
O
ARG
B
262
55.161
−1.109
−17.686
1.00
36.30
B
O


ATOM
12517
N
VAL
B
263
55.504
1.100
−17.747
1.00
30.95
B
N


ATOM
12518
CA
VAL
B
263
54.232
1.419
−18.372
1.00
28.88
B
C


ATOM
12520
CB
VAL
B
263
53.991
2.937
−18.339
1.00
29.02
B
C


ATOM
12522
CG1
VAL
B
263
53.972
3.419
−16.887
1.00
31.64
B
C


ATOM
12526
CG2
VAL
B
263
52.725
3.282
−19.018
1.00
23.71
B
C


ATOM
12530
C
VAL
B
263
54.178
0.879
−19.806
1.00
28.33
B
C


ATOM
12531
O
VAL
B
263
53.120
0.527
−20.282
1.00
28.41
B
O


ATOM
12533
N
GLY
B
264
55.328
0.793
−20.473
1.00
28.72
B
N


ATOM
12534
CA
GLY
B
264
55.455
0.142
−21.782
1.00
28.49
B
C


ATOM
12537
C
GLY
B
264
54.407
0.496
−22.813
1.00
29.83
B
C


ATOM
12538
O
GLY
B
264
54.075
−0.304
−23.665
1.00
33.27
B
O


ATOM
12540
N
LEU
B
265
53.866
1.692
−22.740
1.00
32.92
B
N


ATOM
12541
CA
LEU
B
265
52.709
2.035
−23.561
1.00
36.59
B
C


ATOM
12543
CB
LEU
B
265
52.038
3.282
−22.981
1.00
34.56
B
C


ATOM
12546
CG
LEU
B
265
50.645
3.685
−23.411
1.00
34.01
B
C


ATOM
12548
CD1
LEU
B
265
49.599
2.606
−23.171
1.00
25.90
B
C


ATOM
12552
CD2
LEU
B
265
50.267
4.994
−22.672
1.00
34.22
B
C


ATOM
12556
C
LEU
B
265
53.113
2.229
−25.033
1.00
41.17
B
C


ATOM
12557
O
LEU
B
265
52.405
1.785
−25.947
1.00
40.79
B
O


ATOM
12559
N
ALA
B
266
54.263
2.867
−25.250
1.00
45.34
B
N


ATOM
12560
CA
ALA
B
266
54.839
3.029
−26.591
1.00
49.21
B
C


ATOM
12562
CB
ALA
B
266
56.169
3.765
−26.497
1.00
51.02
B
C


ATOM
12566
C
ALA
B
266
55.042
1.697
−27.325
1.00
51.05
B
C


ATOM
12567
O
ALA
B
266
54.816
1.605
−28.525
1.00
54.29
B
O


ATOM
12569
N
THR
B
267
55.487
0.674
−26.602
1.00
51.62
B
N


ATOM
12570
CA
THR
B
267
55.674
−0.659
−27.166
1.00
50.64
B
C


ATOM
12572
CB
THR
B
267
56.249
−1.603
−26.109
1.00
50.95
B
C


ATOM
12574
OG1
THR
B
267
57.237
−0.904
−25.348
1.00
53.05
B
O


ATOM
12576
CG2
THR
B
267
56.856
−2.837
−26.747
1.00
53.61
B
C


ATOM
12580
C
THR
B
267
54.363
−1.270
−27.629
1.00
49.87
B
C


ATOM
12581
O
THR
B
267
54.276
−1.822
−28.729
1.00
52.54
B
O


ATOM
12583
N
LYS
B
268
53.345
−1.168
−26.781
1.00
47.07
B
N


ATOM
12584
CA
LYS
B
268
52.106
−1.927
−26.953
1.00
45.30
B
C


ATOM
12586
CB
LYS
B
268
51.514
−2.270
−25.578
1.00
45.48
B
C


ATOM
12589
CG
LYS
B
268
52.430
−3.115
−24.675
1.00
45.38
B
C


ATOM
12592
CD
LYS
B
268
52.465
−4.594
−25.090
1.00
49.05
B
C


ATOM
12595
CE
LYS
B
268
53.528
−5.398
−24.328
1.00
51.83
B
C


ATOM
12598
NZ
LYS
B
268
53.838
−6.705
−24.985
1.00
54.82
B
N


ATOM
12602
C
LYS
B
268
51.078
−1.207
−27.819
1.00
43.95
B
C


ATOM
12603
O
LYS
B
268
50.152
−1.829
−28.343
1.00
44.75
B
O


ATOM
12605
N
LEU
B
269
51.229
0.105
−27.947
1.00
43.27
B
N


ATOM
12606
CA
LEU
B
269
50.456
0.896
−28.900
1.00
42.83
B
C


ATOM
12608
CB
LEU
B
269
50.081
2.274
−28.316
1.00
42.53
B
C


ATOM
12611
CG
LEU
B
269
48.694
2.512
−27.709
1.00
42.48
B
C


ATOM
12613
CD1
LEU
B
269
48.340
1.537
−26.633
1.00
40.39
B
C


ATOM
12617
CD2
LEU
B
269
48.603
3.935
−27.181
1.00
43.69
B
C


ATOM
12621
C
LEU
B
269
51.341
1.081
−30.134
1.00
43.67
B
C


ATOM
12622
O
LEU
B
269
52.298
1.875
−30.115
1.00
44.75
B
O


ATOM
12624
N
HIS
B
270
51.014
0.353
−31.200
1.00
42.52
B
N


ATOM
12625
CA
HIS
B
270
51.820
0.323
−32.430
1.00
42.36
B
C


ATOM
12627
CB
HIS
B
270
51.297
−0.765
−33.406
1.00
44.29
B
C


ATOM
12630
CG
HIS
B
270
50.914
−2.062
−32.743
1.00
55.81
B
C


ATOM
12631
ND1
HIS
B
270
51.604
−2.596
−31.670
1.00
59.93
B
N


ATOM
12633
CE1
HIS
B
270
51.038
−3.734
−31.307
1.00
61.45
B
C


ATOM
12635
NE2
HIS
B
270
50.011
−3.964
−32.106
1.00
62.50
B
N


ATOM
12637
CD2
HIS
B
270
49.910
−2.935
−33.012
1.00
61.72
B
C


ATOM
12639
C
HIS
B
270
51.862
1.683
−33.164
1.00
38.47
B
C


ATOM
12640
O
HIS
B
270
52.821
1.980
−33.872
1.00
36.44
B
O


ATOM
12642
N
PHE
B
271
50.813
2.487
−33.019
1.00
34.67
B
N


ATOM
12643
CA
PHE
B
271
50.782
3.831
−33.616
1.00
35.53
B
C


ATOM
12645
CB
PHE
B
271
49.327
4.306
−33.814
1.00
35.09
B
C


ATOM
12648
CG
PHE
B
271
48.598
4.542
−32.527
1.00
32.41
B
C


ATOM
12649
CD1
PHE
B
271
48.680
5.764
−31.891
1.00
36.89
B
C


ATOM
12651
CE1
PHE
B
271
48.031
5.986
−30.662
1.00
42.82
B
C


ATOM
12653
CZ
PHE
B
271
47.311
4.955
−30.061
1.00
41.42
B
C


ATOM
12655
CE2
PHE
B
271
47.234
3.714
−30.695
1.00
43.35
B
C


ATOM
12657
CD2
PHE
B
271
47.881
3.516
−31.920
1.00
37.61
B
C


ATOM
12659
C
PHE
B
271
51.570
4.893
−32.797
1.00
37.13
B
C


ATOM
12660
O
PHE
B
271
51.846
5.976
−33.321
1.00
37.34
B
O


ATOM
12662
N
ALA
B
272
51.940
4.589
−31.543
1.00
37.26
B
N


ATOM
12663
CA
ALA
B
272
52.442
5.634
−30.600
1.00
38.89
B
C


ATOM
12665
CB
ALA
B
272
52.094
5.270
−29.140
1.00
36.66
B
C


ATOM
12669
C
ALA
B
272
53.938
5.971
−30.703
1.00
39.07
B
C


ATOM
12670
O
ALA
B
272
54.797
5.092
−30.725
1.00
39.92
B
O


ATOM
12672
N
ARG
B
273
54.230
7.265
−30.746
1.00
41.88
B
N


ATOM
12673
CA
ARG
B
273
55.598
7.754
−30.590
1.00
43.68
B
C


ATOM
12675
CB
ARG
B
273
55.688
9.247
−30.928
1.00
45.24
B
C


ATOM
12678
CG
ARG
B
273
55.566
9.610
−32.409
1.00
54.15
B
C


ATOM
12681
CD
ARG
B
273
55.488
11.141
−32.589
1.00
58.80
B
C


ATOM
12684
NE
ARG
B
273
54.171
11.685
−32.226
1.00
59.04
B
N


ATOM
12686
CZ
ARG
B
273
53.934
12.957
−31.892
1.00
67.66
B
C


ATOM
12687
NH1
ARG
B
273
54.925
13.849
−31.851
1.00
73.10
B
N


ATOM
12690
NH2
ARG
B
273
52.699
13.348
−31.579
1.00
66.54
B
N


ATOM
12693
C
ARG
B
273
56.033
7.570
−29.146
1.00
42.37
B
C


ATOM
12694
O
ARG
B
273
55.259
7.841
−28.231
1.00
44.16
B
O


ATOM
12696
N
ASP
B
274
57.259
7.102
−28.953
1.00
41.17
B
N


ATOM
12697
CA
ASP
B
274
57.943
7.200
−27.663
1.00
39.65
B
C


ATOM
12699
CB
ASP
B
274
58.887
6.003
−27.479
1.00
37.65
B
C


ATOM
12702
CG
ASP
B
274
59.781
6.132
−26.246
1.00
41.72
B
C


ATOM
12703
OD1
ASP
B
274
59.773
7.202
−25.594
1.00
40.60
B
O


ATOM
12704
OD2
ASP
B
274
60.514
5.165
−25.926
1.00
46.31
B
O


ATOM
12705
C
ASP
B
274
58.730
8.542
−27.618
1.00
39.30
B
C


ATOM
12706
O
ASP
B
274
59.720
8.711
−28.349
1.00
38.18
B
O


ATOM
12708
N
ARG
B
275
58.307
9.459
−26.744
1.00
38.02
B
N


ATOM
12709
CA
ARG
B
275
58.890
10.796
−26.645
1.00
38.08
B
C


ATOM
12711
CB
ARG
B
275
57.833
11.834
−27.058
1.00
39.92
B
C


ATOM
12714
CG
ARG
B
275
57.840
12.200
−28.556
1.00
47.80
B
C


ATOM
12717
CD
ARG
B
275
58.691
13.450
−28.835
1.00
61.16
B
C


ATOM
12720
NE
ARG
B
275
58.526
13.945
−30.206
1.00
68.47
B
N


ATOM
12722
CZ
ARG
B
275
59.096
13.401
−31.281
1.00
74.79
B
C


ATOM
12723
NH1
ARG
B
275
59.875
12.326
−31.169
1.00
76.37
B
N


ATOM
12726
NH2
ARG
B
275
58.876
13.926
−32.484
1.00
75.18
B
N


ATOM
12729
C
ARG
B
275
59.425
11.147
−25.254
1.00
37.19
B
C


ATOM
12730
O
ARG
B
275
59.433
12.316
−24.879
1.00
36.87
B
O


ATOM
12732
N
LEU
B
276
59.886
10.160
−24.485
1.00
37.00
B
N


ATOM
12733
CA
LEU
B
276
60.295
10.426
−23.098
1.00
34.98
B
C


ATOM
12735
CB
LEU
B
276
60.573
9.134
−22.292
1.00
36.67
B
C


ATOM
12738
CG
LEU
B
276
60.890
9.375
−20.797
1.00
35.76
B
C


ATOM
12740
CD1
LEU
B
276
59.754
10.147
−20.115
1.00
33.92
B
C


ATOM
12744
CD2
LEU
B
276
61.169
8.113
−20.053
1.00
36.13
B
C


ATOM
12748
C
LEU
B
276
61.503
11.363
−23.013
1.00
32.92
B
C


ATOM
12749
O
LEU
B
276
61.435
12.361
−22.318
1.00
31.67
B
O


ATOM
12751
N
ILE
B
277
62.582
11.055
−23.725
1.00
30.95
B
N


ATOM
12752
CA
ILE
B
277
63.822
11.841
−23.617
1.00
29.96
B
C


ATOM
12754
CB
ILE
B
277
64.948
11.249
−24.510
1.00
31.64
B
C


ATOM
12756
CG1
ILE
B
277
65.404
9.882
−23.979
1.00
34.19
B
C


ATOM
12759
CD1
ILE
B
277
66.155
9.043
−25.015
1.00
37.10
B
C


ATOM
12763
CG2
ILE
B
277
66.155
12.185
−24.569
1.00
30.97
B
C


ATOM
12767
C
ILE
B
277
63.591
13.296
−24.024
1.00
29.71
B
C


ATOM
12768
O
ILE
B
277
64.075
14.213
−23.367
1.00
29.06
B
O


ATOM
12770
N
GLU
B
278
62.851
13.492
−25.113
1.00
28.47
B
N


ATOM
12771
CA
GLU
B
278
62.515
14.814
−25.599
1.00
30.52
B
C


ATOM
12773
CB
GLU
B
278
61.773
14.746
−26.949
1.00
32.74
B
C


ATOM
12776
CG
GLU
B
278
62.616
14.225
−28.148
1.00
44.05
B
C


ATOM
12779
CD
GLU
B
278
62.477
12.706
−28.437
1.00
50.83
B
C


ATOM
12780
OE1
GLU
B
278
62.589
11.868
−27.508
1.00
47.29
B
O


ATOM
12781
OE2
GLU
B
278
62.263
12.357
−29.624
1.00
59.50
B
O


ATOM
12782
C
GLU
B
278
61.650
15.529
−24.554
1.00
29.96
B
C


ATOM
12783
O
GLU
B
278
61.811
16.720
−24.328
1.00
29.51
B
O


ATOM
12785
N
SER
B
279
60.753
14.787
−23.900
1.00
27.64
B
N


ATOM
12786
CA
SER
B
279
59.880
15.369
−22.906
1.00
24.85
B
C


ATOM
12788
CB
SER
B
279
58.779
14.387
−22.528
1.00
25.36
B
C


ATOM
12791
OG
SER
B
279
57.866
14.222
−23.614
1.00
31.09
B
O


ATOM
12793
C
SER
B
279
60.692
15.817
−21.689
1.00
24.19
B
C


ATOM
12794
O
SER
B
279
60.402
16.841
−21.072
1.00
20.81
B
O


ATOM
12796
N
PHE
B
280
61.726
15.060
−21.358
1.00
22.21
B
N


ATOM
12797
CA
PHE
B
280
62.538
15.405
−20.233
1.00
22.68
B
C


ATOM
12799
CB
PHE
B
280
63.394
14.219
−19.801
1.00
23.70
B
C


ATOM
12802
CG
PHE
B
280
63.993
14.420
−18.458
1.00
22.17
B
C


ATOM
12803
CD1
PHE
B
280
63.282
14.110
−17.326
1.00
26.73
B
C


ATOM
12805
CE1
PHE
B
280
63.815
14.336
−16.082
1.00
28.79
B
C


ATOM
12807
CZ
PHE
B
280
65.071
14.912
−15.977
1.00
26.30
B
C


ATOM
12809
CE2
PHE
B
280
65.767
15.240
−17.094
1.00
23.82
B
C


ATOM
12811
CD2
PHE
B
280
65.224
15.010
−18.332
1.00
25.89
B
C


ATOM
12813
C
PHE
B
280
63.421
16.639
−20.521
1.00
23.35
B
C


ATOM
12814
O
PHE
B
280
63.538
17.546
−19.684
1.00
22.15
B
O


ATOM
12816
N
TYR
B
281
64.035
16.663
−21.702
1.00
22.05
B
N


ATOM
12817
CA
TYR
B
281
64.744
17.845
−22.179
1.00
22.89
B
C


ATOM
12819
CB
TYR
B
281
65.243
17.599
−23.613
1.00
24.85
B
C


ATOM
12822
CG
TYR
B
281
65.725
18.824
−24.340
1.00
27.86
B
C


ATOM
12823
CD1
TYR
B
281
67.038
19.263
−24.199
1.00
29.60
B
C


ATOM
12825
CE1
TYR
B
281
67.481
20.396
−24.830
1.00
30.12
B
C


ATOM
12827
CZ
TYR
B
281
66.619
21.106
−25.645
1.00
27.86
B
C


ATOM
12828
OH
TYR
B
281
67.094
22.218
−26.293
1.00
40.12
B
O


ATOM
12830
CE2
TYR
B
281
65.321
20.681
−25.831
1.00
27.61
B
C


ATOM
12832
CD2
TYR
B
281
64.880
19.541
−25.164
1.00
26.08
B
C


ATOM
12834
C
TYR
B
281
63.774
19.033
−22.107
1.00
23.97
B
C


ATOM
12835
O
TYR
B
281
64.114
20.107
−21.638
1.00
23.50
B
O


ATOM
12837
N
TRP
B
282
62.535
18.821
−22.522
1.00
23.00
B
N


ATOM
12838
CA
TRP
B
282
61.567
19.906
−22.475
1.00
23.33
B
C


ATOM
12840
CB
TRP
B
282
60.235
19.447
−23.059
1.00
22.37
B
C


ATOM
12843
CG
TRP
B
282
59.154
20.412
−22.895
1.00
22.74
B
C


ATOM
12844
CD1
TRP
B
282
58.337
20.555
−21.821
1.00
22.39
B
C


ATOM
12846
NE1
TRP
B
282
57.435
21.564
−22.047
1.00
23.45
B
N


ATOM
12848
CE2
TRP
B
282
57.667
22.082
−23.291
1.00
23.69
B
C


ATOM
12849
CD2
TRP
B
282
58.742
21.375
−23.850
1.00
22.10
B
C


ATOM
12850
CE3
TRP
B
282
59.184
21.712
−25.131
1.00
26.55
B
C


ATOM
12852
CZ3
TRP
B
282
58.546
22.733
−25.798
1.00
28.88
B
C


ATOM
12854
CH2
TRP
B
282
57.483
23.424
−25.210
1.00
30.17
B
C


ATOM
12856
CZ2
TRP
B
282
57.028
23.111
−23.960
1.00
27.03
B
C


ATOM
12858
C
TRP
B
282
61.418
20.387
−21.028
1.00
22.80
B
C


ATOM
12859
O
TRP
B
282
61.406
21.593
−20.769
1.00
20.61
B
O


ATOM
12861
N
ALA
B
283
61.308
19.431
−20.103
1.00
21.05
B
N


ATOM
12862
CA
ALA
B
283
61.084
19.723
−18.692
1.00
20.62
B
C


ATOM
12864
CB
ALA
B
283
60.816
18.452
−17.899
1.00
18.78
B
C


ATOM
12868
C
ALA
B
283
62.249
20.468
−18.081
1.00
19.81
B
C


ATOM
12869
O
ALA
B
283
62.048
21.246
−17.179
1.00
19.59
B
O


ATOM
12871
N
VAL
B
284
63.459
20.228
−18.570
1.00
21.14
B
N


ATOM
12872
CA
VAL
B
284
64.621
20.924
−18.054
1.00
22.45
B
C


ATOM
12874
CB
VAL
B
284
65.935
20.350
−18.615
1.00
25.86
B
C


ATOM
12876
CG1
VAL
B
284
66.234
18.966
−17.953
1.00
18.72
B
C


ATOM
12880
CG2
VAL
B
284
67.075
21.325
−18.378
1.00
20.18
B
C


ATOM
12884
C
VAL
B
284
64.537
22.416
−18.333
1.00
23.71
B
C


ATOM
12885
O
VAL
B
284
64.993
23.221
−17.526
1.00
22.26
B
O


ATOM
12887
N
GLY
B
285
63.948
22.793
−19.464
1.00
21.46
B
N


ATOM
12888
CA
GLY
B
285
63.763
24.215
−19.762
1.00
20.96
B
C


ATOM
12891
C
GLY
B
285
62.773
24.857
−18.808
1.00
21.82
B
C


ATOM
12892
O
GLY
B
285
62.909
26.011
−18.460
1.00
21.74
B
O


ATOM
12894
N
VAL
B
286
61.794
24.090
−18.345
1.00
22.60
B
N


ATOM
12895
CA
VAL
B
286
60.781
24.620
−17.450
1.00
20.48
B
C


ATOM
12897
CB
VAL
B
286
59.539
23.732
−17.498
1.00
23.12
B
C


ATOM
12899
CG1
VAL
B
286
58.485
24.177
−16.490
1.00
20.49
B
C


ATOM
12903
CG2
VAL
B
286
58.976
23.732
−18.955
1.00
17.84
B
C


ATOM
12907
C
VAL
B
286
61.309
24.792
−16.046
1.00
20.31
B
C


ATOM
12908
O
VAL
B
286
61.106
25.842
−15.436
1.00
22.39
B
O


ATOM
12910
N
ALA
B
287
61.979
23.772
−15.527
1.00
19.27
B
N


ATOM
12911
CA
ALA
B
287
62.563
23.827
−14.186
1.00
20.62
B
C


ATOM
12913
CB
ALA
B
287
61.690
23.117
−13.227
1.00
22.01
B
C


ATOM
12917
C
ALA
B
287
63.988
23.242
−14.163
1.00
21.88
B
C


ATOM
12918
O
ALA
B
287
64.196
22.022
−14.069
1.00
24.85
B
O


ATOM
12920
N
PHE
B
288
64.972
24.115
−14.247
1.00
20.90
B
N


ATOM
12921
CA
PHE
B
288
66.345
23.674
−14.426
1.00
21.67
B
C


ATOM
12923
CB
PHE
B
288
67.122
24.674
−15.275
1.00
22.83
B
C


ATOM
12926
CG
PHE
B
288
67.541
25.900
−14.520
1.00
23.91
B
C


ATOM
12927
CD1
PHE
B
288
68.710
25.905
−13.784
1.00
33.80
B
C


ATOM
12929
CE1
PHE
B
288
69.088
27.037
−13.074
1.00
37.48
B
C


ATOM
12931
CZ
PHE
B
288
68.287
28.167
−13.095
1.00
31.38
B
C


ATOM
12933
CE2
PHE
B
288
67.137
28.167
−13.821
1.00
36.32
B
C


ATOM
12935
CD2
PHE
B
288
66.761
27.029
−14.529
1.00
34.62
B
C


ATOM
12937
C
PHE
B
288
67.047
23.497
−13.099
1.00
24.48
B
C


ATOM
12938
O
PHE
B
288
68.005
22.741
−13.031
1.00
23.65
B
O


ATOM
12940
N
GLU
B
289
66.587
24.190
−12.057
1.00
26.02
B
N


ATOM
12941
CA
GLU
B
289
67.310
24.197
−10.792
1.00
29.62
B
C


ATOM
12943
CB
GLU
B
289
66.689
25.166
−9.776
1.00
31.32
B
C


ATOM
12946
CG
GLU
B
289
66.721
26.644
−10.177
1.00
36.70
B
C


ATOM
12949
CD
GLU
B
289
65.440
27.118
−10.890
1.00
45.07
B
C


ATOM
12950
OE1
GLU
B
289
65.081
28.295
−10.677
1.00
47.42
B
O


ATOM
12951
OE2
GLU
B
289
64.793
26.352
−11.659
1.00
39.96
B
O


ATOM
12952
C
GLU
B
289
67.350
22.795
−10.180
1.00
29.55
B
C


ATOM
12953
O
GLU
B
289
66.350
22.084
−10.180
1.00
30.10
B
O


ATOM
12955
N
PRO
B
290
68.495
22.419
−9.606
1.00
29.22
B
N


ATOM
12956
CA
PRO
B
290
68.716
21.062
−9.120
1.00
28.35
B
C


ATOM
12958
CB
PRO
B
290
69.998
21.185
−8.304
1.00
29.34
B
C


ATOM
12961
CG
PRO
B
290
70.632
22.443
−8.746
1.00
31.20
B
C


ATOM
12964
CD
PRO
B
290
69.568
23.338
−9.199
1.00
29.41
B
C


ATOM
12967
C
PRO
B
290
67.597
20.503
−8.245
1.00
27.13
B
C


ATOM
12968
O
PRO
B
290
67.211
19.356
−8.429
1.00
26.99
B
O


ATOM
12969
N
GLN
B
291
67.073
21.317
−7.333
1.00
26.56
B
N


ATOM
12970
CA
GLN
B
291
66.043
20.889
−6.395
1.00
28.08
B
C


ATOM
12972
CB
GLN
B
291
65.903
21.923
−5.273
1.00
28.20
B
C


ATOM
12975
CG
GLN
B
291
65.226
23.240
−5.649
1.00
29.54
B
C


ATOM
12978
CD
GLN
B
291
66.216
24.301
−6.116
1.00
39.09
B
C


ATOM
12979
OE1
GLN
B
291
67.318
23.982
−6.604
1.00
38.40
B
O


ATOM
12980
NE2
GLN
B
291
65.835
25.579
−5.957
1.00
34.88
B
N


ATOM
12983
C
GLN
B
291
64.631
20.595
−6.967
1.00
28.38
B
C


ATOM
12984
O
GLN
B
291
63.778
20.058
−6.256
1.00
28.46
B
O


ATOM
12986
N
TYR
B
292
64.375
20.955
−8.219
1.00
28.39
B
N


ATOM
12987
CA
TYR
B
292
63.043
20.732
−8.817
1.00
29.49
B
C


ATOM
12989
CB
TYR
B
292
62.665
21.897
−9.751
1.00
29.50
B
C


ATOM
12992
CG
TYR
B
292
62.448
23.230
−9.077
1.00
31.00
B
C


ATOM
12993
CD1
TYR
B
292
61.801
23.327
−7.844
1.00
32.31
B
C


ATOM
12995
CE1
TYR
B
292
61.595
24.565
−7.235
1.00
36.98
B
C


ATOM
12997
CZ
TYR
B
292
62.016
25.723
−7.869
1.00
39.38
B
C


ATOM
12998
OH
TYR
B
292
61.804
26.951
−7.281
1.00
45.92
B
O


ATOM
13000
CE2
TYR
B
292
62.634
25.655
−9.106
1.00
42.09
B
C


ATOM
13002
CD2
TYR
B
292
62.849
24.413
−9.701
1.00
39.44
B
C


ATOM
13004
C
TYR
B
292
62.942
19.410
−9.590
1.00
28.42
B
C


ATOM
13005
O
TYR
B
292
62.355
19.362
−10.659
1.00
27.22
B
O


ATOM
13007
N
SER
B
293
63.523
18.344
−9.050
1.00
28.09
B
N


ATOM
13008
CA
SER
B
293
63.430
17.036
−9.669
1.00
28.01
B
C


ATOM
13010
CB
SER
B
293
64.181
15.987
−8.824
1.00
29.51
B
C


ATOM
13013
OG
SER
B
293
65.590
16.068
−9.070
1.00
30.76
B
O


ATOM
13015
C
SER
B
293
61.973
16.635
−9.898
1.00
26.55
B
C


ATOM
13016
O
SER
B
293
61.634
16.155
−10.968
1.00
28.86
B
O


ATOM
13018
N
ASP
B
294
61.120
16.853
−8.907
1.00
25.23
B
N


ATOM
13019
CA
ASP
B
294
59.721
16.469
−9.000
1.00
28.08
B
C


ATOM
13021
CB
ASP
B
294
58.962
16.785
−7.696
1.00
28.58
B
C


ATOM
13024
CG
ASP
B
294
59.432
15.942
−6.522
1.00
37.32
B
C


ATOM
13025
OD1
ASP
B
294
60.154
14.943
−6.741
1.00
36.71
B
O


ATOM
13026
OD2
ASP
B
294
59.094
16.301
−5.363
1.00
45.41
B
O


ATOM
13027
C
ASP
B
294
59.019
17.171
−10.163
1.00
28.26
B
C


ATOM
13028
O
ASP
B
294
58.249
16.544
−10.891
1.00
27.19
B
O


ATOM
13030
N
CYS
B
295
59.261
18.477
−10.298
1.00
26.75
B
N


ATOM
13031
CA
CYS
B
295
58.687
19.249
−11.376
1.00
24.72
B
C


ATOM
13033
CB
CYS
B
295
59.091
20.714
−11.313
1.00
24.78
B
C


ATOM
13036
SG
CYS
B
295
58.157
21.730
−12.489
1.00
24.85
B
S


ATOM
13038
C
CYS
B
295
59.090
18.651
−12.702
1.00
25.01
B
C


ATOM
13039
O
CYS
B
295
58.222
18.397
−13.539
1.00
23.90
B
O


ATOM
13041
N
ARG
B
296
60.386
18.396
−12.893
1.00
24.46
B
N


ATOM
13042
CA
ARG
B
296
60.851
17.831
−14.172
1.00
24.09
B
C


ATOM
13044
CB
ARG
B
296
62.369
17.647
−14.205
1.00
24.77
B
C


ATOM
13047
CG
ARG
B
296
63.153
18.936
−14.354
1.00
23.30
B
C


ATOM
13050
CD
ARG
B
296
64.643
18.682
−14.514
1.00
19.69
B
C


ATOM
13053
NE
ARG
B
296
65.243
18.178
−13.289
1.00
19.76
B
N


ATOM
13055
CZ
ARG
B
296
65.634
18.927
−12.254
1.00
24.50
B
C


ATOM
13056
NH1
ARG
B
296
65.496
20.255
−12.255
1.00
25.75
B
N


ATOM
13059
NH2
ARG
B
296
66.166
18.328
−11.191
1.00
27.06
B
N


ATOM
13062
C
ARG
B
296
60.185
16.495
−14.463
1.00
23.06
B
C


ATOM
13063
O
ARG
B
296
59.718
16.245
−15.597
1.00
22.98
B
O


ATOM
13065
N
ASN
B
297
60.138
15.641
−13.447
1.00
22.07
B
N


ATOM
13066
CA
ASN
B
297
59.565
14.316
−13.609
1.00
24.36
B
C


ATOM
13068
CB
ASN
B
297
59.763
13.460
−12.364
1.00
24.91
B
C


ATOM
13071
CG
ASN
B
297
61.206
13.110
−12.150
1.00
31.79
B
C


ATOM
13072
OD1
ASN
B
297
61.998
13.156
−13.095
1.00
38.41
B
O


ATOM
13073
ND2
ASN
B
297
61.570
12.757
−10.911
1.00
29.95
B
N


ATOM
13076
C
ASN
B
297
58.095
14.399
−13.952
1.00
24.42
B
C


ATOM
13077
O
ASN
B
297
57.622
13.726
−14.876
1.00
23.19
B
O


ATOM
13079
N
SER
B
298
57.393
15.242
−13.215
1.00
23.97
B
N


ATOM
13080
CA
SER
B
298
55.976
15.474
−13.444
1.00
24.63
B
C


ATOM
13082
CB
SER
B
298
55.466
16.475
−12.403
1.00
25.85
B
C


ATOM
13085
OG
SER
B
298
54.275
16.038
−11.808
1.00
36.11
B
O


ATOM
13087
C
SER
B
298
55.694
16.009
−14.851
1.00
23.06
B
C


ATOM
13088
O
SER
B
298
54.827
15.490
−15.572
1.00
21.42
B
O


ATOM
13090
N
VAL
B
299
56.412
17.066
−15.240
1.00
20.75
B
N


ATOM
13091
CA
VAL
B
299
56.238
17.639
−16.554
1.00
18.08
B
C


ATOM
13093
CB
VAL
B
299
57.037
18.933
−16.690
1.00
19.98
B
C


ATOM
13095
CG1
VAL
B
299
57.029
19.453
−18.146
1.00
20.35
B
C


ATOM
13099
CG2
VAL
B
299
56.457
19.960
−15.770
1.00
21.88
B
C


ATOM
13103
C
VAL
B
299
56.636
16.633
−17.648
1.00
19.45
B
C


ATOM
13104
O
VAL
B
299
55.996
16.570
−18.700
1.00
17.92
B
O


ATOM
13106
N
ALA
B
300
57.665
15.826
−17.393
1.00
18.10
B
N


ATOM
13107
CA
ALA
B
300
58.147
14.869
−18.404
1.00
19.47
B
C


ATOM
13109
CB
ALA
B
300
59.535
14.263
−18.011
1.00
15.98
B
C


ATOM
13113
C
ALA
B
300
57.121
13.762
−18.590
1.00
20.75
B
C


ATOM
13114
O
ALA
B
300
56.813
13.354
−19.714
1.00
21.28
B
O


ATOM
13116
N
LYS
B
301
56.573
13.283
−17.482
1.00
21.38
B
N


ATOM
13117
CA
LYS
B
301
55.560
12.239
−17.553
1.00
20.81
B
C


ATOM
13119
CB
LYS
B
301
55.187
11.785
−16.160
1.00
20.47
B
C


ATOM
13122
CG
LYS
B
301
56.259
10.978
−15.481
1.00
20.34
B
C


ATOM
13125
CD
LYS
B
301
55.758
10.422
−14.150
1.00
20.67
B
C


ATOM
13128
CE
LYS
B
301
56.846
9.711
−13.349
1.00
28.61
B
C


ATOM
13131
NZ
LYS
B
301
56.310
9.346
−11.992
1.00
31.10
B
N


ATOM
13135
C
LYS
B
301
54.313
12.719
−18.283
1.00
19.17
B
C


ATOM
13136
O
LYS
B
301
53.752
11.998
−19.088
1.00
19.72
B
O


ATOM
13138
N
MET
B
302
53.880
13.940
−17.995
1.00
18.82
B
N


ATOM
13139
CA
MET
B
302
52.656
14.473
−18.598
1.00
19.48
B
C


ATOM
13141
CB
MET
B
302
52.169
15.752
−17.900
1.00
18.45
B
C


ATOM
13144
CG
MET
B
302
51.728
15.582
−16.463
1.00
16.26
B
C


ATOM
13147
SD
MET
B
302
50.418
14.399
−16.251
1.00
27.62
B
S


ATOM
13148
CE
MET
B
302
51.337
12.933
−15.824
1.00
23.65
B
C


ATOM
13152
C
MET
B
302
52.860
14.765
−20.067
1.00
21.47
B
C


ATOM
13153
O
MET
B
302
52.007
14.431
−20.896
1.00
23.42
B
O


ATOM
13155
N
PHE
B
303
53.966
15.404
−20.412
1.00
21.99
B
N


ATOM
13156
CA
PHE
B
303
54.225
15.621
−21.834
1.00
22.67
B
C


ATOM
13158
CB
PHE
B
303
55.475
16.466
−22.069
1.00
23.73
B
C


ATOM
13161
CG
PHE
B
303
55.398
17.344
−23.304
1.00
31.04
B
C


ATOM
13162
CD1
PHE
B
303
54.200
17.518
−24.009
1.00
29.05
B
C


ATOM
13164
CE1
PHE
B
303
54.144
18.322
−25.144
1.00
42.79
B
C


ATOM
13166
CZ
PHE
B
303
55.280
18.986
−25.577
1.00
41.71
B
C


ATOM
13168
CE2
PHE
B
303
56.469
18.843
−24.877
1.00
37.08
B
C


ATOM
13170
CD2
PHE
B
303
56.525
18.023
−23.742
1.00
37.60
B
C


ATOM
13172
C
PHE
B
303
54.312
14.315
−22.621
1.00
21.08
B
C


ATOM
13173
O
PHE
B
303
53.799
14.238
−23.733
1.00
21.61
B
O


ATOM
13175
N
SER
B
304
54.907
13.277
−22.036
1.00
21.32
B
N


ATOM
13176
CA
SER
B
304
54.949
11.965
−22.692
1.00
20.73
B
C


ATOM
13178
CB
SER
B
304
55.700
10.941
−21.850
1.00
22.39
B
C


ATOM
13181
OG
SER
B
304
57.032
11.374
−21.573
1.00
24.34
B
O


ATOM
13183
C
SER
B
304
53.551
11.444
−22.967
1.00
21.58
B
C


ATOM
13184
O
SER
B
304
53.296
10.929
−24.034
1.00
23.78
B
O


ATOM
13186
N
PHE
B
305
52.639
11.591
−22.011
1.00
21.21
B
N


ATOM
13187
CA
PHE
B
305
51.256
11.195
−22.225
1.00
19.19
B
C


ATOM
13189
CB
PHE
B
305
50.487
11.141
−20.903
1.00
21.39
B
C


ATOM
13192
CG
PHE
B
305
50.574
9.814
−20.230
1.00
22.98
B
C


ATOM
13193
CD1
PHE
B
305
49.894
8.742
−20.738
1.00
22.59
B
C


ATOM
13195
CE1
PHE
B
305
49.983
7.507
−20.135
1.00
23.64
B
C


ATOM
13197
CZ
PHE
B
305
50.747
7.338
−19.024
1.00
24.33
B
C


ATOM
13199
CE2
PHE
B
305
51.435
8.406
−18.505
1.00
27.51
B
C


ATOM
13201
CD2
PHE
B
305
51.349
9.634
−19.112
1.00
22.45
B
C


ATOM
13203
C
PHE
B
305
50.542
12.110
−23.197
1.00
20.45
B
C


ATOM
13204
O
PHE
B
305
49.770
11.631
−24.020
1.00
19.27
B
O


ATOM
13206
N
VAL
B
306
50.791
13.421
−23.126
1.00
20.75
B
N


ATOM
13207
CA
VAL
B
306
50.184
14.351
−24.081
1.00
19.25
B
C


ATOM
13209
CB
VAL
B
306
50.655
15.809
−23.878
1.00
22.43
B
C


ATOM
13211
CG1
VAL
B
306
50.202
16.687
−25.012
1.00
14.46
B
C


ATOM
13215
CG2
VAL
B
306
50.145
16.385
−22.528
1.00
16.22
B
C


ATOM
13219
C
VAL
B
306
50.464
13.914
−25.511
1.00
22.34
B
C


ATOM
13220
O
VAL
B
306
49.566
13.856
−26.316
1.00
23.30
B
O


ATOM
13222
N
THR
B
307
51.696
13.555
−25.830
1.00
25.01
B
N


ATOM
13223
CA
THR
B
307
52.025
13.284
−27.227
1.00
26.57
B
C


ATOM
13225
CB
THR
B
307
53.520
13.087
−27.435
1.00
26.12
B
C


ATOM
13227
OG1
THR
B
307
53.909
11.896
−26.774
1.00
40.17
B
O


ATOM
13229
CG2
THR
B
307
54.339
14.252
−26.872
1.00
33.09
B
C


ATOM
13233
C
THR
B
307
51.284
12.043
−27.757
1.00
26.12
B
C


ATOM
13234
O
THR
B
307
50.866
12.016
−28.903
1.00
25.66
B
O


ATOM
13236
N
ILE
B
308
51.139
11.031
−26.908
1.00
24.81
B
N


ATOM
13237
CA
ILE
B
308
50.352
9.833
−27.215
1.00
23.60
B
C


ATOM
13239
CB
ILE
B
308
50.545
8.768
−26.118
1.00
25.72
B
C


ATOM
13241
CG1
ILE
B
308
51.994
8.263
−26.119
1.00
27.99
B
C


ATOM
13244
CD1
ILE
B
308
52.272
7.297
−24.983
1.00
28.28
B
C


ATOM
13248
CG2
ILE
B
308
49.588
7.595
−26.318
1.00
24.09
B
C


ATOM
13252
C
ILE
B
308
48.865
10.144
−27.337
1.00
22.14
B
C


ATOM
13253
O
ILE
B
308
48.245
9.781
−28.321
1.00
22.79
B
O


ATOM
13255
N
ILE
B
309
48.292
10.823
−26.344
1.00
20.84
B
N


ATOM
13256
CA
ILE
B
309
46.882
11.147
−26.371
1.00
21.20
B
C


ATOM
13258
CB
ILE
B
309
46.435
11.822
−25.093
1.00
22.62
B
C


ATOM
13260
CG1
ILE
B
309
46.643
10.910
−23.874
1.00
26.22
B
C


ATOM
13263
CD1
ILE
B
309
45.698
9.823
−23.812
1.00
38.91
B
C


ATOM
13267
CG2
ILE
B
309
44.993
12.206
−25.188
1.00
18.44
B
C


ATOM
13271
C
ILE
B
309
46.612
12.069
−27.563
1.00
22.75
B
C


ATOM
13272
O
ILE
B
309
45.645
11.896
−28.307
1.00
23.59
B
O


ATOM
13274
N
ASP
B
310
47.506
13.010
−27.796
1.00
22.88
B
N


ATOM
13275
CA
ASP
B
310
47.402
13.867
−28.991
1.00
24.17
B
C


ATOM
13277
CB
ASP
B
310
48.606
14.828
−29.062
1.00
25.25
B
C


ATOM
13280
CG
ASP
B
310
48.464
15.924
−30.125
1.00
31.57
B
C


ATOM
13281
OD1
ASP
B
310
47.362
16.203
−30.614
1.00
41.50
B
O


ATOM
13282
OD2
ASP
B
310
49.503
16.528
−30.461
1.00
46.26
B
O


ATOM
13283
C
ASP
B
310
47.268
13.005
−30.264
1.00
23.28
B
C


ATOM
13284
O
ASP
B
310
46.344
13.216
−31.032
1.00
22.28
B
O


ATOM
13286
N
ASP
B
311
48.139
12.012
−30.464
1.00
23.05
B
N


ATOM
13287
CA
ASP
B
311
48.040
11.175
−31.666
1.00
25.68
B
C


ATOM
13289
CB
ASP
B
311
49.146
10.136
−31.720
1.00
27.71
B
C


ATOM
13292
CG
ASP
B
311
50.509
10.741
−31.947
1.00
35.42
B
C


ATOM
13293
OD1
ASP
B
311
50.567
11.862
−32.501
1.00
39.96
B
O


ATOM
13294
OD2
ASP
B
311
51.516
10.092
−31.558
1.00
44.33
B
O


ATOM
13295
C
ASP
B
311
46.703
10.442
−31.770
1.00
24.73
B
C


ATOM
13296
O
ASP
B
311
46.168
10.275
−32.866
1.00
25.59
B
O


ATOM
13298
N
ILE
B
312
46.169
9.998
−30.640
1.00
21.14
B
N


ATOM
13299
CA
ILE
B
312
44.901
9.300
−30.658
1.00
20.46
B
C


ATOM
13301
CB
ILE
B
312
44.558
8.792
−29.225
1.00
21.25
B
C


ATOM
13303
CG1
ILE
B
312
45.428
7.566
−28.870
1.00
22.56
B
C


ATOM
13306
CD1
ILE
B
312
45.327
7.127
−27.386
1.00
15.81
B
C


ATOM
13310
CG2
ILE
B
312
43.089
8.428
−29.087
1.00
17.97
B
C


ATOM
13314
C
ILE
B
312
43.803
10.213
−31.251
1.00
22.04
B
C


ATOM
13315
O
ILE
B
312
43.047
9.805
−32.119
1.00
21.87
B
O


ATOM
13317
N
TYR
B
313
43.700
11.445
−30.756
1.00
24.10
B
N


ATOM
13318
CA
TYR
B
313
42.717
12.413
−31.269
1.00
22.33
B
C


ATOM
13320
CB
TYR
B
313
42.602
13.613
−30.321
1.00
22.53
B
C


ATOM
13323
CG
TYR
B
313
41.860
13.350
−29.049
1.00
18.01
B
C


ATOM
13324
CD1
TYR
B
313
40.533
13.713
−28.908
1.00
15.63
B
C


ATOM
13326
CE1
TYR
B
313
39.838
13.478
−27.730
1.00
18.26
B
C


ATOM
13328
CZ
TYR
B
313
40.489
12.864
−26.664
1.00
22.61
B
C


ATOM
13329
OH
TYR
B
313
39.833
12.629
−25.474
1.00
18.89
B
O


ATOM
13331
CE2
TYR
B
313
41.811
12.496
−26.785
1.00
23.65
B
C


ATOM
13333
CD2
TYR
B
313
42.486
12.734
−27.977
1.00
22.64
B
C


ATOM
13335
C
TYR
B
313
43.080
12.921
−32.665
1.00
22.74
B
C


ATOM
13336
O
TYR
B
313
42.214
13.176
−33.481
1.00
22.56
B
O


ATOM
13338
N
ASP
B
314
44.365
13.066
−32.950
1.00
25.71
B
N


ATOM
13339
CA
ASP
B
314
44.768
13.652
−34.221
1.00
26.66
B
C


ATOM
13341
CB
ASP
B
314
46.227
14.059
−34.185
1.00
28.17
B
C


ATOM
13344
CG
ASP
B
314
46.668
14.758
−35.459
1.00
34.44
B
C


ATOM
13345
OD1
ASP
B
314
45.874
15.565
−35.987
1.00
35.69
B
O


ATOM
13346
OD2
ASP
B
314
47.809
14.501
−35.924
1.00
42.75
B
O


ATOM
13347
C
ASP
B
314
44.529
12.699
−35.409
1.00
26.37
B
C


ATOM
13348
O
ASP
B
314
43.935
13.112
−36.405
1.00
24.33
B
O


ATOM
13350
N
VAL
B
315
44.949
11.441
−35.282
1.00
24.78
B
N


ATOM
13351
CA
VAL
B
315
44.922
10.484
−36.415
1.00
25.23
B
C


ATOM
13353
CB
VAL
B
315
46.340
10.251
−36.987
1.00
23.87
B
C


ATOM
13355
CG1
VAL
B
315
46.851
11.532
−37.688
1.00
27.00
B
C


ATOM
13359
CG2
VAL
B
315
47.289
9.792
−35.902
1.00
22.09
B
C


ATOM
13363
C
VAL
B
315
44.305
9.096
−36.185
1.00
25.17
B
C


ATOM
13364
O
VAL
B
315
43.729
8.544
−37.109
1.00
27.94
B
O


ATOM
13366
N
TYR
B
316
44.426
8.520
−34.993
1.00
24.11
B
N


ATOM
13367
CA
TYR
B
316
44.020
7.122
−34.779
1.00
23.73
B
C


ATOM
13369
CB
TYR
B
316
44.867
6.522
−33.672
1.00
25.65
B
C


ATOM
13372
CG
TYR
B
316
44.824
5.019
−33.620
1.00
27.69
B
C


ATOM
13373
CD1
TYR
B
316
45.597
4.235
−34.499
1.00
25.15
B
C


ATOM
13375
CE1
TYR
B
316
45.550
2.814
−34.447
1.00
25.74
B
C


ATOM
13377
CZ
TYR
B
316
44.740
2.208
−33.503
1.00
24.05
B
C


ATOM
13378
OH
TYR
B
316
44.669
0.862
−33.392
1.00
25.86
B
O


ATOM
13380
CE2
TYR
B
316
43.966
2.972
−32.630
1.00
31.18
B
C


ATOM
13382
CD2
TYR
B
316
44.012
4.368
−32.692
1.00
27.68
B
C


ATOM
13384
C
TYR
B
316
42.540
6.883
−34.427
1.00
23.79
B
C


ATOM
13385
O
TYR
B
316
41.897
5.976
−34.977
1.00
23.24
B
O


ATOM
13387
N
GLY
B
317
41.999
7.665
−33.502
1.00
21.86
B
N


ATOM
13388
CA
GLY
B
317
40.677
7.383
−32.966
1.00
20.83
B
C


ATOM
13391
C
GLY
B
317
39.577
7.917
−33.858
1.00
23.66
B
C


ATOM
13392
O
GLY
B
317
39.701
9.008
−34.444
1.00
21.52
B
O


ATOM
13394
N
THR
B
318
38.490
7.152
−33.975
1.00
22.28
B
N


ATOM
13395
CA
THR
B
318
37.315
7.674
−34.607
1.00
22.27
B
C


ATOM
13397
CB
THR
B
318
36.314
6.564
−34.989
1.00
23.50
B
C


ATOM
13399
OG1
THR
B
318
35.746
6.006
−33.803
1.00
25.49
B
O


ATOM
13401
CG2
THR
B
318
37.006
5.456
−35.807
1.00
21.97
B
C


ATOM
13405
C
THR
B
318
36.625
8.610
−33.638
1.00
23.75
B
C


ATOM
13406
O
THR
B
318
36.823
8.542
−32.412
1.00
23.62
B
O


ATOM
13408
N
LEU
B
319
35.757
9.446
−34.189
1.00
22.45
B
N


ATOM
13409
CA
LEU
B
319
35.009
10.398
−33.393
1.00
24.74
B
C


ATOM
13411
CB
LEU
B
319
34.040
11.176
−34.274
1.00
24.05
B
C


ATOM
13414
CG
LEU
B
319
33.903
12.670
−34.012
1.00
34.66
B
C


ATOM
13416
CD1
LEU
B
319
35.268
13.345
−33.825
1.00
22.94
B
C


ATOM
13420
CD2
LEU
B
319
33.063
13.338
−35.150
1.00
33.27
B
C


ATOM
13424
C
LEU
B
319
34.273
9.736
−32.238
1.00
24.81
B
C


ATOM
13425
O
LEU
B
319
34.300
10.224
−31.127
1.00
27.70
B
O


ATOM
13427
N
ASP
B
320
33.637
8.605
−32.498
1.00
26.74
B
N


ATOM
13428
CA
ASP
B
320
32.910
7.881
−31.469
1.00
26.27
B
C


ATOM
13430
CB
ASP
B
320
32.192
6.650
−32.064
1.00
29.58
B
C


ATOM
13433
CG
ASP
B
320
30.855
6.977
−32.760
1.00
35.82
B
C


ATOM
13434
OD1
ASP
B
320
30.397
8.145
−32.767
1.00
38.73
B
O


ATOM
13435
OD2
ASP
B
320
30.261
6.018
−33.315
1.00
45.55
B
O


ATOM
13436
C
ASP
B
320
33.857
7.413
−30.361
1.00
23.93
B
C


ATOM
13437
O
ASP
B
320
33.509
7.435
−29.199
1.00
23.76
B
O


ATOM
13439
N
GLU
B
321
35.044
6.951
−30.724
1.00
23.54
B
N


ATOM
13440
CA
GLU
B
321
35.977
6.478
−29.721
1.00
22.08
B
C


ATOM
13442
CB
GLU
B
321
37.129
5.748
−30.378
1.00
21.78
B
C


ATOM
13445
CG
GLU
B
321
36.748
4.435
−31.077
1.00
21.27
B
C


ATOM
13448
CD
GLU
B
321
37.959
3.809
−31.762
1.00
25.99
B
C


ATOM
13449
OE1
GLU
B
321
38.908
4.571
−32.114
1.00
24.28
B
O


ATOM
13450
OE2
GLU
B
321
37.983
2.569
−31.922
1.00
26.77
B
O


ATOM
13451
C
GLU
B
321
36.506
7.668
−28.909
1.00
22.57
B
C


ATOM
13452
O
GLU
B
321
36.761
7.548
−27.714
1.00
21.71
B
O


ATOM
13454
N
LEU
B
322
36.665
8.813
−29.569
1.00
21.65
B
N


ATOM
13455
CA
LEU
B
322
37.187
9.993
−28.909
1.00
22.06
B
C


ATOM
13457
CB
LEU
B
322
37.611
11.059
−29.909
1.00
20.94
B
C


ATOM
13460
CG
LEU
B
322
38.692
10.615
−30.885
1.00
20.78
B
C


ATOM
13462
CD1
LEU
B
322
38.999
11.683
−31.924
1.00
17.20
B
C


ATOM
13466
CD2
LEU
B
322
39.949
10.199
−30.146
1.00
17.86
B
C


ATOM
13470
C
LEU
B
322
36.169
10.546
−27.927
1.00
23.46
B
C


ATOM
13471
O
LEU
B
322
36.555
11.005
−26.852
1.00
24.73
B
O


ATOM
13473
N
GLU
B
323
34.880
10.460
−28.243
1.00
21.53
B
N


ATOM
13474
CA
GLU
B
323
33.875
10.850
−27.261
1.00
23.97
B
C


ATOM
13476
CB
GLU
B
323
32.469
10.840
−27.851
1.00
26.47
B
C


ATOM
13479
CG
GLU
B
323
32.292
11.810
−29.011
1.00
31.79
B
C


ATOM
13482
CD
GLU
B
323
31.723
13.145
−28.600
1.00
39.43
B
C


ATOM
13483
OE1
GLU
B
323
31.263
13.876
−29.515
1.00
44.91
B
O


ATOM
13484
OE2
GLU
B
323
31.713
13.459
−27.383
1.00
40.00
B
O


ATOM
13485
C
GLU
B
323
33.930
9.940
−26.030
1.00
24.87
B
C


ATOM
13486
O
GLU
B
323
33.810
10.409
−24.899
1.00
23.87
B
O


ATOM
13488
N
LEU
B
324
34.129
8.643
−26.238
1.00
24.68
B
N


ATOM
13489
CA
LEU
B
324
34.224
7.719
−25.099
1.00
24.65
B
C


ATOM
13491
CB
LEU
B
324
34.330
6.249
−25.566
1.00
25.50
B
C


ATOM
13494
CG
LEU
B
324
33.033
5.612
−26.107
1.00
31.61
B
C


ATOM
13496
CD1
LEU
B
324
33.328
4.286
−26.843
1.00
26.20
B
C


ATOM
13500
CD2
LEU
B
324
32.020
5.401
−24.966
1.00
29.59
B
C


ATOM
13504
C
LEU
B
324
35.403
8.054
−24.199
1.00
22.74
B
C


ATOM
13505
O
LEU
B
324
35.294
7.976
−22.983
1.00
22.76
B
O


ATOM
13507
N
PHE
B
325
36.539
8.406
−24.794
1.00
21.75
B
N


ATOM
13508
CA
PHE
B
325
37.765
8.651
−24.017
1.00
19.99
B
C


ATOM
13510
CB
PHE
B
325
38.977
8.726
−24.943
1.00
18.14
B
C


ATOM
13513
CG
PHE
B
325
40.293
8.727
−24.222
1.00
20.43
B
C


ATOM
13514
CD1
PHE
B
325
40.921
7.542
−23.911
1.00
20.73
B
C


ATOM
13516
CE1
PHE
B
325
42.133
7.529
−23.250
1.00
18.54
B
C


ATOM
13518
CZ
PHE
B
325
42.741
8.712
−22.890
1.00
18.75
B
C


ATOM
13520
CE2
PHE
B
325
42.129
9.912
−23.189
1.00
29.13
B
C


ATOM
13522
CD2
PHE
B
325
40.901
9.918
−23.855
1.00
20.29
B
C


ATOM
13524
C
PHE
B
325
37.660
9.930
−23.215
1.00
19.39
B
C


ATOM
13525
O
PHE
B
325
38.067
9.999
−22.050
1.00
21.89
B
O


ATOM
13527
N
THR
B
326
37.153
10.956
−23.872
1.00
20.85
B
N


ATOM
13528
CA
THR
B
326
36.929
12.251
−23.274
1.00
21.29
B
C


ATOM
13530
CB
THR
B
326
36.274
13.175
−24.300
1.00
22.64
B
C


ATOM
13532
OG1
THR
B
326
37.159
13.340
−25.420
1.00
21.93
B
O


ATOM
13534
CG2
THR
B
326
35.978
14.532
−23.685
1.00
15.42
B
C


ATOM
13538
C
THR
B
326
36.034
12.107
−22.056
1.00
21.59
B
C


ATOM
13539
O
THR
B
326
36.334
12.624
−21.006
1.00
22.13
B
O


ATOM
13541
N
ASP
B
327
34.952
11.363
−22.213
1.00
25.12
B
N


ATOM
13542
CA
ASP
B
327
33.991
11.091
−21.144
1.00
24.52
B
C


ATOM
13544
CB
ASP
B
327
32.805
10.309
−21.729
1.00
26.23
B
C


ATOM
13547
CG
ASP
B
327
31.880
9.726
−20.654
1.00
35.17
B
C


ATOM
13548
OD1
ASP
B
327
31.041
10.485
−20.095
1.00
38.22
B
O


ATOM
13549
OD2
ASP
B
327
31.994
8.499
−20.370
1.00
41.20
B
O


ATOM
13550
C
ASP
B
327
34.635
10.320
−20.002
1.00
24.61
B
C


ATOM
13551
O
ASP
B
327
34.422
10.642
−18.824
1.00
25.19
B
O


ATOM
13553
N
ALA
B
328
35.440
9.313
−20.339
1.00
22.67
B
N


ATOM
13554
CA
ALA
B
328
36.152
8.535
−19.326
1.00
21.90
B
C


ATOM
13556
CB
ALA
B
328
36.923
7.388
−19.966
1.00
21.68
B
C


ATOM
13560
C
ALA
B
328
37.102
9.399
−18.487
1.00
21.10
B
C


ATOM
13561
O
ALA
B
328
37.245
9.183
−17.287
1.00
20.62
B
O


ATOM
13563
N
VAL
B
329
37.762
10.356
−19.118
1.00
18.66
B
N


ATOM
13564
CA
VAL
B
329
38.652
11.232
−18.405
1.00
18.17
B
C


ATOM
13566
CB
VAL
B
329
39.547
12.030
−19.362
1.00
18.54
B
C


ATOM
13568
CG1
VAL
B
329
40.599
11.070
−20.002
1.00
20.31
B
C


ATOM
13572
CG2
VAL
B
329
40.267
13.148
−18.630
1.00
16.84
B
C


ATOM
13576
C
VAL
B
329
37.841
12.144
−17.498
1.00
22.27
B
C


ATOM
13577
O
VAL
B
329
38.210
12.343
−16.342
1.00
24.05
B
O


ATOM
13579
N
GLU
B
330
36.725
12.664
−17.999
1.00
22.49
B
N


ATOM
13580
CA
GLU
B
330
35.830
13.499
−17.185
1.00
24.53
B
C


ATOM
13582
CB
GLU
B
330
34.638
14.006
−18.032
1.00
23.64
B
C


ATOM
13585
CG
GLU
B
330
35.054
15.060
−19.039
1.00
29.46
B
C


ATOM
13588
CD
GLU
B
330
33.972
15.467
−20.043
1.00
36.72
B
C


ATOM
13589
OE1
GLU
B
330
34.141
16.536
−20.688
1.00
38.15
B
O


ATOM
13590
OE2
GLU
B
330
32.969
14.739
−20.205
1.00
39.50
B
O


ATOM
13591
C
GLU
B
330
35.321
12.765
−15.952
1.00
25.12
B
C


ATOM
13592
O
GLU
B
330
35.371
13.295
−14.850
1.00
24.76
B
O


ATOM
13594
N
ARG
B
331
34.843
11.537
−16.129
1.00
26.13
B
N


ATOM
13595
CA
AARG
B
331
34.264
10.779
−15.016
0.50
25.43
B
C


ATOM
13596
CA
BARG
B
331
34.261
10.787
−15.019
0.50
25.52
B
C


ATOM
13599
CB
AARG
B
331
33.385
9.643
−15.539
0.50
25.68
B
C


ATOM
13600
CB
BARG
B
331
33.350
9.683
−15.563
0.50
25.87
B
C


ATOM
13605
CG
AARG
B
331
32.054
10.133
−16.144
0.50
29.23
B
C


ATOM
13606
CG
BARG
B
331
32.115
10.255
−16.312
0.50
29.59
B
C


ATOM
13611
CD
AARG
B
331
31.197
8.990
−16.686
0.50
32.54
B
C


ATOM
13612
CD
BARG
B
331
31.212
9.190
−16.943
0.50
32.56
B
C


ATOM
13617
NE
AARG
B
331
32.007
8.014
−17.403
0.50
39.07
B
N


ATOM
13618
NE
BARG
B
331
30.097
9.778
−17.691
0.50
37.34
B
N


ATOM
13621
CZ
AARG
B
331
32.223
6.766
−17.000
0.50
36.77
B
C


ATOM
13622
CZ
BARG
B
331
28.967
10.208
−17.135
0.50
40.94
B
C


ATOM
13623
NH1
AARG
B
331
31.656
6.300
−15.886
0.50
38.70
B
N


ATOM
13624
NH1
BARG
B
331
28.782
10.113
−15.825
0.50
38.56
B
N


ATOM
13629
NH2
AARG
B
331
32.998
5.985
−17.733
0.50
33.12
B
N


ATOM
13630
NH2
BARG
B
331
28.016
10.734
−17.891
0.50
39.98
B
N


ATOM
13635
C
ARG
B
331
35.327
10.245
−14.044
1.00
25.39
B
C


ATOM
13636
O
ARG
B
331
35.081
10.116
−12.841
1.00
23.54
B
O


ATOM
13638
N
TRP
B
332
36.509
9.935
−14.559
1.00
24.49
B
N


ATOM
13639
CA
TRP
B
332
37.622
9.451
−13.737
1.00
22.84
B
C


ATOM
13641
CB
TRP
B
332
38.153
10.576
−12.838
1.00
19.58
B
C


ATOM
13644
CG
TRP
B
332
39.557
10.379
−12.453
1.00
19.36
B
C


ATOM
13645
CD1
TRP
B
332
40.027
9.997
−11.234
1.00
18.47
B
C


ATOM
13647
NE1
TRP
B
332
41.393
9.903
−11.264
1.00
21.06
B
N


ATOM
13649
CE2
TRP
B
332
41.831
10.202
−12.524
1.00
17.15
B
C


ATOM
13650
CD2
TRP
B
332
40.701
10.503
−13.302
1.00
20.00
B
C


ATOM
13651
CE3
TRP
B
332
40.875
10.827
−14.648
1.00
16.76
B
C


ATOM
13653
CZ3
TRP
B
332
42.149
10.869
−15.154
1.00
18.63
B
C


ATOM
13655
CH2
TRP
B
332
43.257
10.567
−14.354
1.00
21.96
B
C


ATOM
13657
CZ2
TRP
B
332
43.115
10.241
−13.033
1.00
23.99
B
C


ATOM
13659
C
TRP
B
332
37.252
8.223
−12.919
1.00
21.89
B
C


ATOM
13660
O
TRP
B
332
37.517
8.160
−11.715
1.00
21.86
B
O


ATOM
13662
N
ASP
B
333
36.660
7.240
−13.591
1.00
22.25
B
N


ATOM
13663
CA
ASP
B
333
36.126
6.051
−12.932
1.00
24.19
B
C


ATOM
13665
CB
ASP
B
333
34.598
5.972
−13.154
1.00
24.72
B
C


ATOM
13668
CG
ASP
B
333
33.947
4.754
−12.473
1.00
28.67
B
C


ATOM
13669
OD1
ASP
B
333
34.580
4.096
−11.612
1.00
32.90
B
O


ATOM
13670
OD2
ASP
B
333
32.773
4.466
−12.795
1.00
34.32
B
O


ATOM
13671
C
ASP
B
333
36.796
4.790
−13.490
1.00
24.39
B
C


ATOM
13672
O
ASP
B
333
36.486
4.352
−14.599
1.00
23.16
B
O


ATOM
13674
N
VAL
B
334
37.673
4.183
−12.699
1.00
24.63
B
N


ATOM
13675
CA
VAL
B
334
38.392
3.011
−13.157
1.00
25.01
B
C


ATOM
13677
CB
VAL
B
334
39.571
2.670
−12.260
1.00
24.07
B
C


ATOM
13679
CG1
VAL
B
334
40.484
1.692
−12.972
1.00
22.74
B
C


ATOM
13683
CG2
VAL
B
334
39.094
2.132
−10.916
1.00
22.48
B
C


ATOM
13687
C
VAL
B
334
37.471
1.805
−13.298
1.00
28.84
B
C


ATOM
13688
O
VAL
B
334
37.724
0.960
−14.132
1.00
30.66
B
O


ATOM
13690
N
ASN
B
335
36.384
1.751
−12.530
1.00
30.57
B
N


ATOM
13691
CA
ASN
B
335
35.396
0.670
−12.667
1.00
32.76
B
C


ATOM
13693
CB
ASN
B
335
34.426
0.659
−11.474
1.00
32.97
B
C


ATOM
13696
CG
ASN
B
335
35.150
0.526
−10.136
1.00
36.11
B
C


ATOM
13697
OD1
ASN
B
335
35.846
−0.464
−9.891
1.00
32.01
B
O


ATOM
13698
ND2
ASN
B
335
35.002
1.537
−9.272
1.00
31.45
B
N


ATOM
13701
C
ASN
B
335
34.595
0.714
−13.973
1.00
33.61
B
C


ATOM
13702
O
ASN
B
335
33.783
−0.158
−14.187
1.00
32.20
B
O


ATOM
13704
N
ALA
B
336
34.819
1.725
−14.821
1.00
35.40
B
N


ATOM
13705
CA
ALA
B
336
34.165
1.832
−16.139
1.00
37.44
B
C


ATOM
13707
CB
ALA
B
336
33.391
3.153
−16.239
1.00
36.12
B
C


ATOM
13711
C
ALA
B
336
35.147
1.708
−17.306
1.00
37.97
B
C


ATOM
13712
O
ALA
B
336
34.797
1.970
−18.451
1.00
40.52
B
O


ATOM
13714
N
ILE
B
337
36.371
1.291
−17.006
1.00
39.74
B
N


ATOM
13715
CA
ILE
B
337
37.417
1.027
−18.010
1.00
39.19
B
C


ATOM
13717
CB
ILE
B
337
38.706
0.448
−17.308
1.00
40.69
B
C


ATOM
13719
CG1
ILE
B
337
39.903
0.392
−18.237
1.00
45.92
B
C


ATOM
13722
CD1
ILE
B
337
41.134
−0.183
−17.566
1.00
45.35
B
C


ATOM
13726
CG2
ILE
B
337
38.488
−0.946
−16.773
1.00
38.80
B
C


ATOM
13730
C
ILE
B
337
36.959
0.093
−19.138
1.00
39.32
B
C


ATOM
13731
O
ILE
B
337
37.385
0.260
−20.278
1.00
39.83
B
O


ATOM
13733
N
ASN
B
338
36.080
−0.866
−18.837
1.00
37.82
B
N


ATOM
13734
CA
ASN
B
338
35.609
−1.831
−19.854
1.00
38.11
B
C


ATOM
13736
CB
ASN
B
338
34.944
−3.076
−19.201
1.00
37.75
B
C


ATOM
13739
CG
ASN
B
338
35.970
−4.092
−18.627
1.00
38.84
B
C


ATOM
13740
OD1
ASN
B
338
37.163
−4.064
−18.937
1.00
33.79
B
O


ATOM
13741
ND2
ASN
B
338
35.479
−5.010
−17.801
1.00
36.06
B
N


ATOM
13744
C
ASN
B
338
34.705
−1.253
−20.973
1.00
36.95
B
C


ATOM
13745
O
ASN
B
338
34.464
−1.915
−21.965
1.00
36.60
B
O


ATOM
13747
N
ASP
B
339
34.243
−0.019
−20.839
1.00
37.98
B
N


ATOM
13748
CA
ASP
B
339
33.479
0.647
−21.920
1.00
38.56
B
C


ATOM
13750
CB
ASP
B
339
32.804
1.938
−21.394
1.00
40.02
B
C


ATOM
13753
CG
ASP
B
339
31.899
1.706
−20.161
1.00
44.52
B
C


ATOM
13754
OD1
ASP
B
339
31.430
0.568
−19.940
1.00
49.31
B
O


ATOM
13755
OD2
ASP
B
339
31.641
2.690
−19.430
1.00
45.68
B
O


ATOM
13756
C
ASP
B
339
34.381
1.036
−23.110
1.00
34.68
B
C


ATOM
13757
O
ASP
B
339
33.918
1.279
−24.221
1.00
34.99
B
O


ATOM
13759
N
LEU
B
340
35.674
1.116
−22.855
1.00
31.43
B
N


ATOM
13760
CA
LEU
B
340
36.619
1.597
−23.846
1.00
29.09
B
C


ATOM
13762
CB
LEU
B
340
37.803
2.257
−23.138
1.00
27.62
B
C


ATOM
13765
CG
LEU
B
340
37.483
3.472
−22.279
1.00
26.44
B
C


ATOM
13767
CD1
LEU
B
340
38.682
3.873
−21.426
1.00
20.10
B
C


ATOM
13771
CD2
LEU
B
340
37.050
4.595
−23.174
1.00
24.57
B
C


ATOM
13775
C
LEU
B
340
37.145
0.464
−24.725
1.00
25.95
B
C


ATOM
13776
O
LEU
B
340
37.281
−0.666
−24.260
1.00
26.50
B
O


ATOM
13778
N
PRO
B
341
37.472
0.773
−25.984
1.00
24.08
B
N


ATOM
13779
CA
PRO
B
341
38.167
−0.187
−26.836
1.00
24.62
B
C


ATOM
13781
CB
PRO
B
341
38.191
0.493
−28.218
1.00
24.85
B
C


ATOM
13784
CG
PRO
B
341
38.063
1.910
−27.954
1.00
26.60
B
C


ATOM
13787
CD
PRO
B
341
37.281
2.065
−26.661
1.00
25.30
B
C


ATOM
13790
C
PRO
B
341
39.564
−0.443
−26.320
1.00
23.26
B
C


ATOM
13791
O
PRO
B
341
40.103
0.360
−25.544
1.00
21.32
B
O


ATOM
13792
N
ASP
B
342
40.134
−1.571
−26.725
1.00
23.87
B
N


ATOM
13793
CA
ASP
B
342
41.289
−2.122
−26.026
1.00
23.29
B
C


ATOM
13795
CB
ASP
B
342
41.767
−3.425
−26.696
1.00
25.56
B
C


ATOM
13798
CG
ASP
B
342
40.790
−4.605
−26.491
1.00
31.22
B
C


ATOM
13799
OD1
ASP
B
342
39.943
−4.549
−25.566
1.00
32.95
B
O


ATOM
13800
OD2
ASP
B
342
40.889
−5.599
−27.254
1.00
37.04
B
O


ATOM
13801
C
ASP
B
342
42.436
−1.120
−25.929
1.00
22.80
B
C


ATOM
13802
O
ASP
B
342
43.042
−0.938
−24.845
1.00
21.42
B
O


ATOM
13804
N
TYR
B
343
42.747
−0.457
−27.039
1.00
20.42
B
N


ATOM
13805
CA
TYR
B
343
43.912
0.428
−27.038
1.00
20.57
B
C


ATOM
13807
CB
TYR
B
343
44.273
0.888
−28.460
1.00
20.66
B
C


ATOM
13810
CG
TYR
B
343
43.398
1.977
−29.041
1.00
23.23
B
C


ATOM
13811
CD1
TYR
B
343
42.233
1.680
−29.747
1.00
20.78
B
C


ATOM
13813
CE1
TYR
B
343
41.441
2.700
−30.274
1.00
26.89
B
C


ATOM
13815
CZ
TYR
B
343
41.836
4.026
−30.103
1.00
23.64
B
C


ATOM
13816
OH
TYR
B
343
41.124
5.055
−30.630
1.00
26.31
B
O


ATOM
13818
CE2
TYR
B
343
42.993
4.332
−29.437
1.00
22.44
B
C


ATOM
13820
CD2
TYR
B
343
43.765
3.316
−28.910
1.00
23.71
B
C


ATOM
13822
C
TYR
B
343
43.689
1.603
−26.069
1.00
20.00
B
C


ATOM
13823
O
TYR
B
343
44.602
2.031
−25.396
1.00
18.99
B
O


ATOM
13825
N
MET
B
344
42.459
2.080
−25.966
1.00
20.82
B
N


ATOM
13826
CA
MET
B
344
42.145
3.158
−25.030
1.00
20.77
B
C


ATOM
13828
CB
MET
B
344
40.819
3.806
−25.392
1.00
20.51
B
C


ATOM
13831
CG
MET
B
344
40.953
4.773
−26.564
1.00
21.38
B
C


ATOM
13834
SD
MET
B
344
39.418
5.528
−27.088
1.00
22.33
B
S


ATOM
13835
CE
MET
B
344
40.022
6.860
−28.132
1.00
16.19
B
C


ATOM
13839
C
MET
B
344
42.134
2.677
−23.591
1.00
22.13
B
C


ATOM
13840
O
MET
B
344
42.497
3.420
−22.682
1.00
20.90
B
O


ATOM
13842
N
LYS
B
345
41.731
1.427
−23.402
1.00
23.38
B
N


ATOM
13843
CA
LYS
B
345
41.726
0.791
−22.077
1.00
24.79
B
C


ATOM
13845
CB
LYS
B
345
41.476
−0.712
−22.211
1.00
27.00
B
C


ATOM
13848
CG
LYS
B
345
40.331
−1.290
−21.421
1.00
35.72
B
C


ATOM
13851
CD
LYS
B
345
39.732
−2.426
−22.257
1.00
37.84
B
C


ATOM
13854
CE
LYS
B
345
38.753
−3.251
−21.507
1.00
39.59
B
C


ATOM
13857
NZ
LYS
B
345
37.824
−3.918
−22.467
1.00
43.84
B
N


ATOM
13861
C
LYS
B
345
43.082
0.957
−21.458
1.00
21.39
B
C


ATOM
13862
O
LYS
B
345
43.214
1.460
−20.349
1.00
21.62
B
O


ATOM
13864
N
LEU
B
346
44.086
0.500
−22.192
1.00
19.29
B
N


ATOM
13865
CA
LEU
B
346
45.449
0.496
−21.723
1.00
20.97
B
C


ATOM
13867
CB
LEU
B
346
46.322
−0.210
−22.743
1.00
21.36
B
C


ATOM
13870
CG
LEU
B
346
47.675
−0.639
−22.223
1.00
23.78
B
C


ATOM
13872
CD1
LEU
B
346
47.477
−1.675
−21.112
1.00
20.34
B
C


ATOM
13876
CD2
LEU
B
346
48.444
−1.253
−23.370
1.00
27.71
B
C


ATOM
13880
C
LEU
B
346
45.958
1.908
−21.486
1.00
21.00
B
C


ATOM
13881
O
LEU
B
346
46.523
2.225
−20.433
1.00
21.92
B
O


ATOM
13883
N
CYS
B
347
45.753
2.763
−22.469
1.00
19.96
B
N


ATOM
13884
CA
CYS
B
347
46.241
4.139
−22.383
1.00
21.49
B
C


ATOM
13886
CB
CYS
B
347
45.945
4.847
−23.725
1.00
23.29
B
C


ATOM
13889
SG
CYS
B
347
46.580
6.488
−23.807
1.00
37.91
B
S


ATOM
13891
C
CYS
B
347
45.571
4.880
−21.211
1.00
19.02
B
C


ATOM
13892
O
CYS
B
347
46.215
5.622
−20.460
1.00
16.76
B
O


ATOM
13894
N
PHE
B
348
44.271
4.649
−21.038
1.00
18.76
B
N


ATOM
13895
CA
PHE
B
348
43.529
5.306
−19.983
1.00
18.67
B
C


ATOM
13897
CB
PHE
B
348
42.035
5.009
−20.055
1.00
17.98
B
C


ATOM
13900
CG
PHE
B
348
41.269
5.635
−18.939
1.00
17.07
B
C


ATOM
13901
CD1
PHE
B
348
41.030
6.990
−18.933
1.00
21.41
B
C


ATOM
13903
CE1
PHE
B
348
40.352
7.592
−17.885
1.00
23.96
B
C


ATOM
13905
CZ
PHE
B
348
39.939
6.844
−16.815
1.00
21.12
B
C


ATOM
13907
CE2
PHE
B
348
40.191
5.484
−16.803
1.00
22.43
B
C


ATOM
13909
CD2
PHE
B
348
40.867
4.894
−17.855
1.00
21.94
B
C


ATOM
13911
C
PHE
B
348
44.032
4.868
−18.616
1.00
18.84
B
C


ATOM
13912
O
PHE
B
348
44.286
5.700
−17.738
1.00
17.72
B
O


ATOM
13914
N
LEU
B
349
44.174
3.562
−18.429
1.00
17.46
B
N


ATOM
13915
CA
LEU
B
349
44.520
3.063
−17.118
1.00
18.56
B
C


ATOM
13917
CB
LEU
B
349
44.388
1.545
−17.053
1.00
19.12
B
C


ATOM
13920
CG
LEU
B
349
44.690
0.832
−15.727
1.00
19.64
B
C


ATOM
13922
CD1
LEU
B
349
44.000
1.519
−14.535
1.00
13.56
B
C


ATOM
13926
CD2
LEU
B
349
44.259
−0.634
−15.855
1.00
11.45
B
C


ATOM
13930
C
LEU
B
349
45.926
3.532
−16.771
1.00
19.38
B
C


ATOM
13931
O
LEU
B
349
46.196
3.873
−15.620
1.00
16.91
B
O


ATOM
13933
N
ALA
B
350
46.810
3.590
−17.774
1.00
21.32
B
N


ATOM
13934
CA
ALA
B
350
48.189
4.094
−17.560
1.00
20.38
B
C


ATOM
13936
CB
ALA
B
350
49.004
3.959
−18.854
1.00
20.36
B
C


ATOM
13940
C
ALA
B
350
48.232
5.538
−17.068
1.00
17.92
B
C


ATOM
13941
O
ALA
B
350
48.948
5.872
−16.148
1.00
15.97
B
O


ATOM
13943
N
LEU
B
351
47.493
6.400
−17.747
1.00
19.62
B
N


ATOM
13944
CA
LEU
B
351
47.334
7.796
−17.357
1.00
18.33
B
C


ATOM
13946
CB
LEU
B
351
46.440
8.505
−18.390
1.00
21.12
B
C


ATOM
13949
CG
LEU
B
351
46.123
9.988
−18.131
1.00
23.41
B
C


ATOM
13951
CD1
LEU
B
351
47.364
10.823
−18.236
1.00
19.59
B
C


ATOM
13955
CD2
LEU
B
351
45.052
10.462
−19.098
1.00
22.85
B
C


ATOM
13959
C
LEU
B
351
46.694
7.924
−15.972
1.00
18.87
B
C


ATOM
13960
O
LEU
B
351
47.165
8.709
−15.117
1.00
19.16
B
O


ATOM
13962
N
TYR
B
352
45.604
7.176
−15.780
1.00
16.72
B
N


ATOM
13963
CA
TYR
B
352
44.870
7.128
−14.520
1.00
16.75
B
C


ATOM
13965
CB
TYR
B
352
43.799
6.040
−14.614
1.00
18.50
B
C


ATOM
13968
CG
TYR
B
352
42.765
5.984
−13.519
1.00
17.16
B
C


ATOM
13969
CD1
TYR
B
352
41.688
6.868
−13.514
1.00
22.74
B
C


ATOM
13971
CE1
TYR
B
352
40.702
6.807
−12.524
1.00
21.64
B
C


ATOM
13973
CZ
TYR
B
352
40.788
5.858
−11.535
1.00
21.98
B
C


ATOM
13974
OH
TYR
B
352
39.800
5.795
−10.560
1.00
25.58
B
O


ATOM
13976
CE2
TYR
B
352
41.861
4.956
−11.528
1.00
19.79
B
C


ATOM
13978
CD2
TYR
B
352
42.828
5.022
−12.524
1.00
17.06
B
C


ATOM
13980
C
TYR
B
352
45.801
6.835
−13.363
1.00
16.79
B
C


ATOM
13981
O
TYR
B
352
45.874
7.601
−12.384
1.00
17.65
B
O


ATOM
13983
N
ASN
B
353
46.534
5.734
−13.460
1.00
16.33
B
N


ATOM
13984
CA
ASN
B
353
47.437
5.356
−12.361
1.00
18.36
B
C


ATOM
13986
CB
ASN
B
353
48.058
3.995
−12.629
1.00
15.27
B
C


ATOM
13989
CG
ASN
B
353
47.068
2.864
−12.502
1.00
19.46
B
C


ATOM
13990
OD1
ASN
B
353
45.965
3.037
−11.982
1.00
17.65
B
O


ATOM
13991
ND2
ASN
B
353
47.463
1.677
−12.969
1.00
15.56
B
N


ATOM
13994
C
ASN
B
353
48.538
6.420
−12.127
1.00
18.63
B
C


ATOM
13995
O
ASN
B
353
48.930
6.688
−10.994
1.00
13.58
B
O


ATOM
13997
N
THR
B
354
49.012
7.047
−13.210
1.00
19.49
B
N


ATOM
13998
CA
THR
B
354
50.102
7.999
−13.110
1.00
17.67
B
C


ATOM
14000
CB
THR
B
354
50.610
8.406
−14.501
1.00
20.08
B
C


ATOM
14002
OG1
THR
B
354
51.004
7.243
−15.238
1.00
18.36
B
O


ATOM
14004
CG2
THR
B
354
51.789
9.381
−14.389
1.00
17.15
B
C


ATOM
14008
C
THR
B
354
49.634
9.239
−12.347
1.00
18.15
B
C


ATOM
14009
O
THR
B
354
50.316
9.713
−11.462
1.00
18.88
B
O


ATOM
14011
N
ILE
B
355
48.454
9.728
−12.694
1.00
16.69
B
N


ATOM
14012
CA
ILE
B
355
47.908
10.920
−12.095
1.00
17.85
B
C


ATOM
14014
CB
ILE
B
355
46.657
11.416
−12.875
1.00
18.34
B
C


ATOM
14016
CG1
ILE
B
355
46.999
11.833
−14.317
1.00
21.17
B
C


ATOM
14019
CD1
ILE
B
355
48.356
12.354
−14.519
1.00
25.46
B
C


ATOM
14023
CG2
ILE
B
355
45.993
12.558
−12.164
1.00
19.09
B
C


ATOM
14027
C
ILE
B
355
47.550
10.632
−10.630
1.00
17.55
B
C


ATOM
14028
O
ILE
B
355
47.954
11.376
−9.729
1.00
14.98
B
O


ATOM
14030
N
ASN
B
356
46.806
9.557
−10.387
1.00
17.07
B
N


ATOM
14031
CA
ASN
B
356
46.532
9.152
−9.008
1.00
18.16
B
C


ATOM
14033
CB
ASN
B
356
45.687
7.874
−8.941
1.00
17.23
B
C


ATOM
14036
CG
ASN
B
356
44.314
8.080
−9.531
1.00
17.52
B
C


ATOM
14037
OD1
ASN
B
356
43.925
9.217
−9.798
1.00
25.68
B
O


ATOM
14038
ND2
ASN
B
356
43.592
7.004
−9.782
1.00
19.09
B
N


ATOM
14041
C
ASN
B
356
47.783
9.003
−8.161
1.00
19.24
B
C


ATOM
14042
O
ASN
B
356
47.765
9.283
−6.975
1.00
22.07
B
O


ATOM
14044
N
GLU
B
357
48.885
8.596
−8.752
1.00
21.23
B
N


ATOM
14045
CA
GLU
B
357
50.112
8.425
−7.967
1.00
19.96
B
C


ATOM
14047
CB
GLU
B
357
51.064
7.495
−8.708
1.00
18.90
B
C


ATOM
14050
CG
GLU
B
357
52.445
7.346
−8.117
1.00
34.11
B
C


ATOM
14053
CD
GLU
B
357
53.308
6.403
−8.934
1.00
49.89
B
C


ATOM
14054
OE1
GLU
B
357
54.545
6.565
−8.899
1.00
54.67
B
O


ATOM
14055
OE2
GLU
B
357
52.742
5.520
−9.630
1.00
62.79
B
O


ATOM
14056
C
GLU
B
357
50.738
9.782
−7.660
1.00
18.63
B
C


ATOM
14057
O
GLU
B
357
51.308
9.983
−6.589
1.00
17.61
B
O


ATOM
14059
N
ILE
B
358
50.625
10.741
−8.571
1.00
20.13
B
N


ATOM
14060
CA
ILE
B
358
51.074
12.094
−8.246
1.00
19.81
B
C


ATOM
14062
CB
ILE
B
358
51.160
12.978
−9.495
1.00
23.03
B
C


ATOM
14064
CG1
ILE
B
358
52.286
12.481
−10.418
1.00
23.28
B
C


ATOM
14067
CD1
ILE
B
358
52.104
12.900
−11.898
1.00
17.88
B
C


ATOM
14071
CG2
ILE
B
358
51.438
14.454
−9.111
1.00
18.37
B
C


ATOM
14075
C
ILE
B
358
50.150
12.692
−7.164
1.00
19.64
B
C


ATOM
14076
O
ILE
B
358
50.621
13.279
−6.196
1.00
18.49
B
O


ATOM
14078
N
ALA
B
359
48.835
12.505
−7.298
1.00
21.04
B
N


ATOM
14079
CA
ALA
B
359
47.910
12.942
−6.247
1.00
19.40
B
C


ATOM
14081
CB
ALA
B
359
46.510
12.504
−6.556
1.00
16.36
B
C


ATOM
14085
C
ALA
B
359
48.371
12.364
−4.920
1.00
21.14
B
C


ATOM
14086
O
ALA
B
359
48.372
13.050
−3.874
1.00
22.13
B
O


ATOM
14088
N
TYR
B
360
48.815
11.108
−4.955
1.00
19.16
B
N


ATOM
14089
CA
TYR
B
360
49.215
10.452
−3.712
1.00
18.42
B
C


ATOM
14091
CB
TYR
B
360
49.446
8.947
−3.887
1.00
15.75
B
C


ATOM
14094
CG
TYR
B
360
49.888
8.307
−2.601
1.00
12.33
B
C


ATOM
14095
CD1
TYR
B
360
48.972
7.920
−1.649
1.00
13.40
B
C


ATOM
14097
CE1
TYR
B
360
49.371
7.368
−0.458
1.00
9.59
B
C


ATOM
14099
CZ
TYR
B
360
50.716
7.214
−0.194
1.00
15.43
B
C


ATOM
14100
OH
TYR
B
360
51.132
6.646
1.000
1.00
13.06
B
O


ATOM
14102
CE2
TYR
B
360
51.646
7.606
−1.132
1.00
12.26
B
C


ATOM
14104
CD2
TYR
B
360
51.233
8.143
−2.315
1.00
12.87
B
C


ATOM
14106
C
TYR
B
360
50.424
11.100
−3.604
1.00
16.88
B
C


ATOM
14107
O
TYR
B
360
50.434
11.292
−1.857
1.00
16.26
B
O


ATOM
14109
N
ASP
B
361
51.445
11.406
−3.855
1.00
19.15
B
N


ATOM
14110
CA
ASP
B
361
52.668
12.027
−3.354
1.00
20.70
B
C


ATOM
14112
CB
ASP
B
361
53.668
12.338
−4.492
1.00
22.88
B
C


ATOM
14115
CG
ASP
B
361
54.242
11.079
−5.177
1.00
30.52
B
C


ATOM
14116
OD1
ASP
B
361
54.385
10.017
−4.519
1.00
34.4
B
O


ATOM
14117
OD2
ASP
B
361
54.556
11.171
−6.382
1.00
37.22
B
O


ATOM
14118
C
ASP
B
361
52.319
13.350
−2.676
1.00
22.70
B
C


ATOM
14119
O
ASP
B
361
52.856
13.697
−1.635
1.00
21.32
B
O


ATOM
14121
N
ASN
B
362
51.427
14.097
−3.308
1.00
22.85
B
N


ATOM
14122
CA
ASN
B
362
50.995
15.345
−2.761
1.00
23.65
B
C


ATOM
14124
CB
ASN
B
3362
50.210
16.111
−3.804
1.00
25.00
B
C


ATOM
14127
CG
ASN
B
362
51.100
16.886
−4.672
1.00
30.68
B
C


ATOM
14128
OD1
ASN
B
362
51.508
17.995
−4.301
1.00
29.31
B
O


ATOM
14129
ND2
ASN
B
362
51.492
16.295
−5.823
1.00
34.07
B
N


ATOM
14132
C
ASN
B
362
50.178
15.225
−1.495
1.00
22.70
B
C


ATOM
14133
O
ASN
B
362
50.337
16.038
−0.590
1.00
22.27
B
O


ATOM
14135
N
LEU
B
363
49.292
14.249
−1.438
1.00
20.22
B
N


ATOM
14136
CA
LEU
B
363
48.564
14.000
−0.210
1.00
20.99
B
C


ATOM
14138
CB
LEU
B
363
47.544
12.874
−0.388
1.00
19.03
B
C


ATOM
14141
CG
LEU
B
363
46.668
12.477
0.809
1.00
22.46
B
C


ATOM
14143
CD1
LEU
B
363
45.834
13.657
1.352
1.00
16.50
B
C


ATOM
14147
CD2
LEU
B
363
45.75
11.304
0.456
1.00
15.67
B
C


ATOM
14151
C
LEU
B
363
49.582
13.669
0.868
1.00
21.81
B
C


ATOM
14152
O
LEU
B
363
49.546
14.234
1.950
1.00
22.89
B
O


ATOM
14154
N
LYS
B
364
50.531
12.798
0.558
1.00
24.05
B
N


ATOM
14155
CA
LYS
B
364
51.494
12.362
1.566
1.00
24.81
B
C


ATOM
14157
CB
LYS
B
364
52.416
11.272
1.015
1.00
24.82
B
C


ATOM
14160
CG
LYS
B
364
53.281
10.584
2.058
1.00
27.90
B
C


ATOM
14163
CD
LYS
B
364
54.170
9.479
1.430
1.00
31.07
B
C


ATOM
14166
CE
LYS
B
364
55.496
9.983
0.869
1.00
27.35
B
C


ATOM
14169
NZ
LYS
B
364
55.461
10.244
−0.578
1.00
39.19
B
N


ATOM
14173
C
LYS
B
364
52.340
13.526
2.066
1.00
26.11
B
C


ATOM
14174
O
LYS
B
364
52.554
13.650
3.281
1.00
23.11
B
O


ATOM
14176
N
ASP
B
365
52.838
14.349
1.133
1.00
25.89
B
N


ATOM
14177
CA
ASP
B
365
53.864
15.347
1.466
1.00
29.64
B
C


ATOM
14179
CB
ASP
B
365
54.815
15.590
0.286
1.00
31.01
B
C


ATOM
14182
CG
ASP
B
365
55.574
14.334
−0.135
1.00
40.18
B
C


ATOM
14183
OD1
ASP
B
365
55.800
13.438
0.719
1.00
43.63
B
C


ATOM
14184
OD2
ASP
B
365
55.939
14.257
−1.336
1.00
47.50
B
O


ATOM
14185
C
ASP
B
365
53.276
16.680
1.907
1.00
29.07
B
C


ATOM
14186
O
ASP
B
365
53.883
17.378
2.696
1.00
31.54
B
O


ATOM
14188
N
LYS
B
366
52.104
17.028
1.395
1.00
28.84
B
N


ATOM
14189
CA
LYS
B
366
51.490
18.322
1.681
1.00
31.06
B
C


ATOM
14191
CB
LYS
B
366
51.269
19.114
0.382
1.00
31.40
B
C


ATOM
14194
CG
LYS
B
366
52.545
19.404
−0.401
1.00
37.02
B
C


ATOM
14197
CD
LYS
B
366
52.242
20.235
−1.658
1.00
53.13
B
C


ATOM
14200
CE
LYS
B
366
53.336
20.108
−2.732
1.00
53.38
B
C


ATOM
14203
NZ
LYS
B
366
54.714
20.334
−2.185
1.00
64.76
B
N


ATOM
14207
C
LYS
B
366
50.172
18.210
2.446
1.00
31.50
B
C


ATOM
14208
O
LYS
B
366
49.653
19.220
2.915
1.00
33.61
B
O


ATOM
14210
N
GLY
B
367
49.631
17.002
2.579
1.00
28.68
B
N


ATOM
14211
CA
GLY
B
367
48.409
16.804
3.338
1.00
27.28
B
C


ATOM
14214
C
GLY
B
367
47.191
17.406
2.685
1.00
27.99
B
C


ATOM
14215
O
GLY
B
367
46.250
17.788
3.386
1.00
28.42
B
O


ATOM
14217
N
GLU
B
368
47.203
17.468
1.347
1.00
27.86
B
N


ATOM
14218
CA
GLU
B
368
46.081
17.979
0.547
1.00
27.52
B
C


ATOM
14220
CB
GLU
B
368
46.450
19.330
−0.095
1.00
30.43
B
C


ATOM
14223
CG
GLU
B
368
46.948
20.426
0.862
1.00
39.15
B
C


ATOM
14226
CD
GLU
B
368
45.836
21.137
1.619
1.00
47.36
B
C


ATOM
14227
OE1
GLU
B
368
44.658
20.703
1.548
1.00
49.41
B
O


ATOM
14228
OE2
GLU
B
368
46.162
22.142
2.291
1.00
53.64
B
O


ATOM
14229
C
GLU
B
368
45.713
17.032
−0.591
1.00
24.33
B
C


ATOM
14230
O
GLU
B
368
46.584
16.536
−1.308
1.00
22.31
B
O


ATOM
14232
N
ASN
B
369
44.421
16.800
−0.764
1.00
23.20
B
N


ATOM
14233
CA
ASN
B
369
43.909
16.123
−1.947
1.00
23.98
B
C


ATOM
14235
CB
ASN
B
369
42.532
15.541
−1.671
1.00
23.61
B
C


ATOM
14238
CG
ASN
B
369
42.019
14.665
−2.820
1.00
28.43
B
C


ATOM
14239
OD1
ASN
B
369
42.646
14.562
−3.880
1.00
27.91
B
O


ATOM
14240
ND2
ASN
B
369
40.871
14.015
−2.597
1.00
22.66
B
N


ATOM
14243
C
ASN
B
369
43.806
17.093
−3.129
1.00
23.36
B
C


ATOM
14244
O
ASN
B
369
42.863
17.874
−3.200
1.00
24.65
B
O


ATOM
14246
N
ILE
B
370
44.751
17.015
−4.059
1.00
21.14
B
N


ATOM
14247
CA
ILE
B
370
44.723
17.849
−5.249
1.00
21.55
B
C


ATOM
14249
CB
ILE
B
370
46.137
18.417
−5.572
1.00
22.76
B
C


ATOM
14251
CG1
ILE
B
370
47.140
17.296
−5.847
1.00
22.92
B
C


ATOM
14254
CD1
ILE
B
370
48.345
17.766
−6.586
1.00
25.13
B
C


ATOM
14258
CG2
ILE
B
370
46.639
19.311
−4.433
1.00
21.02
B
C


ATOM
14262
C
ILE
B
370
44.180
17.118
−6.492
1.00
22.16
B
C


ATOM
14263
O
ILE
B
370
44.222
17.661
−7.593
1.00
21.34
B
O


ATOM
14265
N
LEU
B
371
43.669
15.898
−6.330
1.00
20.03
B
N


ATOM
14266
CA
LEU
B
371
43.260
15.105
−7.485
1.00
20.80
B
C


ATOM
14268
CB
LEU
B
371
42.735
13.735
−7.052
1.00
19.94
B
C


ATOM
14271
CG
LEU
B
371
42.452
12.746
−8.191
1.00
22.27
B
C


ATOM
14273
CD1
LEU
B
371
43.736
12.396
−8.973
1.00
16.64
B
C


ATOM
14277
CD2
LEU
B
371
41.792
11.477
−7.642
1.00
18.00
B
C


ATOM
14281
C
LEU
B
371
42.219
15.800
−8.387
1.00
22.85
B
C


ATOM
14282
O
LEU
B
371
42.340
15.738
−9.623
1.00
24.00
B
O


ATOM
14284
N
PRO
B
372
41.201
16.468
−7.787
1.00
23.30
B
N


ATOM
14285
CA
PRO
B
372
40.201
17.090
−8.648
1.00
23.58
B
C


ATOM
14287
CB
PRO
B
372
39.225
17.761
−7.670
1.00
24.01
B
C


ATOM
14290
CG
PRO
B
372
39.457
17.118
−6.376
1.00
28.41
B
C


ATOM
14293
CD
PRO
B
372
40.897
16.685
−6.359
1.00
25.80
B
C


ATOM
14296
C
PRO
B
372
40.804
18.105
−9.604
1.00
22.18
B
C


ATOM
14297
O
PRO
B
372
40.310
18.227
−10.701
1.00
23.54
B
O


ATOM
14298
N
TYR
B
373
41.867
18.790
−9.195
1.00
21.49
B
N


ATOM
14299
CA
TYR
B
373
42.552
19.781
−10.047
1.00
24.02
B
C


ATOM
14301
CB
TYR
B
373
43.456
20.714
−9.213
1.00
25.06
B
C


ATOM
14304
CG
TYR
B
373
42.747
21.255
−7.971
1.00
28.99
B
C


ATOM
14305
CD1
TYR
B
373
41.617
22.058
−8.083
1.00
37.98
B
C


ATOM
14307
CE1
TYR
B
373
40.932
22.510
−6.958
1.00
38.97
B
C


ATOM
14309
CZ
TYR
B
373
41.378
22.165
−5.709
1.00
40.12
B
C


ATOM
14310
OH
TYR
B
373
40.713
22.610
−4.589
1.00
48.27
B
O


ATOM
14312
CE2
TYR
B
373
42.488
21.359
−5.568
1.00
40.83
B
C


ATOM
14314
CD2
TYR
B
373
43.160
20.898
−6.702
1.00
33.96
B
C


ATOM
14316
C
TYR
B
373
43.366
19.107
−11.147
1.00
25.44
B
C


ATOM
14317
O
TYR
B
373
43.388
19.591
−12.283
1.00
26.29
B
O


ATOM
14319
N
LEU
B
374
44.013
17.980
−10.834
1.00
24.17
B
N


ATOM
14320
CA
LEU
B
374
44.808
17.285
−11.844
1.00
20.73
B
C


ATOM
14322
CB
LEU
B
374
45.721
16.236
−11.224
1.00
20.86
B
C


ATOM
14325
CG
LEU
B
374
46.684
16.702
−10.130
1.00
20.24
B
C


ATOM
14327
CD1
LEU
B
374
47.543
15.508
−9.612
1.00
16.80
B
C


ATOM
14331
CD2
LEU
B
374
47.562
17.841
−10.572
1.00
17.67
B
C


ATOM
14335
C
LEU
B
374
43.891
16.659
−12.869
1.00
18.95
B
C


ATOM
14336
O
LEU
B
374
44.166
16.700
−14.059
1.00
20.39
B
O


ATOM
14338
N
THR
B
375
42.772
16.107
−12.439
1.00
20.66
B
N


ATOM
14339
CA
THR
B
375
41.896
15.466
−13.399
1.00
19.66
B
C


ATOM
14341
CB
THR
B
375
40.958
14.480
−12.726
1.00
21.51
B
C


ATOM
14343
OG1
THR
B
375
40.128
15.161
−11.787
1.00
22.47
B
O


ATOM
14345
CG2
THR
B
375
41.788
13.374
−12.020
1.00
15.76
B
C


ATOM
14349
C
THR
B
375
41.130
16.486
−14.248
1.00
22.51
B
C


ATOM
14350
O
THR
B
375
40.859
16.249
−15.429
1.00
23.67
B
O


ATOM
14352
N
LYS
B
376
40.798
17.631
−13.670
1.00
23.19
B
N


ATOM
14353
CA
LYS
B
376
40.133
18.683
−14.434
1.00
24.29
B
C


ATOM
14355
CB
LYS
B
376
39.727
19.837
−13.517
1.00
25.69
B
C


ATOM
14358
CG
LYS
B
376
38.961
20.963
−14.212
1.00
32.29
B
C


ATOM
14361
CD
LYS
B
376
37.580
20.536
−14.716
1.00
36.20
B
C


ATOM
14364
CE
LYS
B
376
36.881
21.706
−15.449
1.00
39.50
B
C


ATOM
14367
NZ
LYS
B
376
35.532
21.322
−15.952
1.00
46.03
B
N


ATOM
14371
C
LYS
B
376
41.050
19.181
−15.535
1.00
21.89
B
C


ATOM
14372
O
LYS
B
376
40.614
19.403
−16.653
1.00
24.65
B
O


ATOM
14374
N
ALA
B
377
42.325
19.356
−15.222
1.00
20.03
B
N


ATOM
14375
CA
ALA
B
377
43.294
19.765
−16.228
1.00
18.15
B
C


ATOM
14377
CB
ALA
B
377
44.692
19.870
−15.637
1.00
18.15
B
C


ATOM
14381
C
ALA
B
377
43.283
18.775
−17.366
1.00
18.11
B
C


ATOM
14382
O
ALA
B
377
43.257
19.189
−18.533
1.00
18.41
B
O


ATOM
14384
N
TRP
B
378
43.258
17.473
−17.059
1.00
17.59
B
N


ATOM
14385
CA
TRP
B
378
43.221
16.492
−18.146
1.00
19.76
B
C


ATOM
14387
CB
TRP
B
378
43.567
15.063
−17.701
1.00
20.21
B
C


ATOM
14390
CG
TRP
B
378
45.032
14.853
−17.733
1.00
19.57
B
C


ATOM
14391
CD1
TRP
B
378
45.905
14.995
−16.696
1.00
16.98
B
C


ATOM
14393
NE1
TRP
B
378
47.183
14.779
−17.128
1.00
19.55
B
N


ATOM
14395
CE2
TRP
B
378
47.152
14.483
−18.466
1.00
17.20
B
C


ATOM
14396
CD2
TRP
B
378
45.816
14.528
−18.878
1.00
17.73
B
C


ATOM
14397
CE3
TRP
B
378
45.512
14.282
−20.216
1.00
19.66
B
C


ATOM
14399
CZ3
TRP
B
378
46.530
13.995
−21.082
1.00
21.97
B
C


ATOM
14401
CH2
TRP
B
378
47.851
13.935
−20.644
1.00
21.81
B
C


ATOM
14403
CZ2
TRP
B
378
48.188
14.197
−19.340
1.00
20.44
B
C


ATOM
14405
C
TRP
B
378
41.919
16.552
−18.924
1.00
19.35
B
C


ATOM
14406
O
TRP
B
378
41.929
16.331
−20.136
1.00
20.96
B
O


ATOM
14408
N
ALA
B
379
40.821
16.846
−18.242
1.00
17.74
B
N


ATOM
14409
CA
ALA
B
379
39.499
16.867
−18.893
1.00
20.62
B
C


ATOM
14411
CB
ALA
B
379
38.337
17.003
−17.854
1.00
20.87
B
C


ATOM
14415
C
ALA
B
379
39.443
18.014
−19.877
1.00
20.85
B
C


ATOM
14416
O
ALA
B
379
38.957
17.853
−20.998
1.00
22.78
B
O


ATOM
14418
N
ASP
B
380
39.966
19.164
−19.467
1.00
19.02
B
N


ATOM
14419
CA
ASP
B
380
40.048
20.318
−20.354
1.00
20.32
B
C


ATOM
14421
CB
ASP
B
380
40.580
21.538
−19.611
1.00
22.48
B
C


ATOM
14424
CG
ASP
B
380
39.628
22.029
−18.535
1.00
22.07
B
C


ATOM
14425
OD1
ASP
B
380
38.441
21.626
−18.530
1.00
25.90
B
O


ATOM
14426
OD2
ASP
B
380
40.081
22.808
−17.697
1.00
25.80
B
O


ATOM
14427
C
ASP
B
380
40.920
20.075
−21.561
1.00
20.78
B
C


ATOM
14428
O
ASP
B
380
40.604
20.529
−22.650
1.00
24.69
B
O


ATOM
14430
N
LEU
B
381
42.016
19.361
−21.385
1.00
20.48
B
N


ATOM
14431
CA
LEU
B
381
42.894
19.074
−22.504
1.00
19.96
B
C


ATOM
14433
CB
LEU
B
381
44.226
18.505
−22.047
1.00
18.35
B
C


ATOM
14436
CG
LEU
B
381
45.196
18.161
−23.167
1.00
22.53
B
C


ATOM
14438
CD1
LEU
B
381
45.503
19.376
−24.030
1.00
16.10
B
C


ATOM
14442
CD2
LEU
B
381
46.453
17.579
−22.589
1.00
16.33
B
C


ATOM
14446
C
LEU
B
381
42.197
18.127
−23.456
1.00
19.12
B
C


ATOM
14447
O
LEU
B
381
42.162
18.365
−24.641
1.00
19.21
B
O


ATOM
14449
N
CYS
B
382
41.610
17.060
−22.943
1.00
20.99
B
N


ATOM
14450
CA
CYS
B
382
40.929
16.115
−23.842
1.00
19.91
B
C


ATOM
14452
CB
CYS
B
382
40.480
14.866
−23.077
1.00
19.91
B
C


ATOM
14455
SG
CYS
B
382
41.915
13.875
−22.517
1.00
24.88
B
S


ATOM
14457
C
CYS
B
382
39.775
16.780
−24.594
1.00
19.49
B
C


ATOM
14458
O
CYS
B
382
39.598
16.514
−25.774
1.00
22.41
B
O


ATOM
14460
N
ASN
B
383
39.013
17.660
−23.938
1.00
19.54
B
N


ATOM
14461
CA
ASN
B
383
37.953
18.433
−24.628
1.00
19.38
B
C


ATOM
14463
CB
ASN
B
383
37.078
19.250
−23.644
1.00
17.80
B
C


ATOM
14466
CG
ASN
B
383
35.976
18.410
−23.013
1.00
21.83
B
C


ATOM
14467
OD1
ASN
B
383
35.030
18.011
−23.692
1.00
28.68
B
O


ATOM
14468
ND2
ASN
B
383
36.105
18.115
−21.715
1.00
19.68
B
N


ATOM
14471
C
ASN
B
383
38.514
19.360
−25.704
1.00
20.03
B
C


ATOM
14472
O
ASN
B
383
37.876
19.576
−26.722
1.00
21.15
B
O


ATOM
14474
N
ALA
B
384
39.708
19.905
−25.491
1.00
19.68
B
N


ATOM
14475
CA
ALA
B
384
40.312
20.759
−26.500
1.00
18.25
B
C


ATOM
14477
CB
ALA
B
384
41.412
21.600
−25.902
1.00
16.95
B
C


ATOM
14481
C
ALA
B
384
40.799
19.897
−27.676
1.00
19.74
B
C


ATOM
14482
O
ALA
B
384
40.642
20.274
−28.845
1.00
20.58
B
O


ATOM
14484
N
PHE
B
385
41.308
18.706
−27.396
1.00
19.10
B
N


ATOM
14485
CA
PHE
B
385
41.644
17.783
−28.492
1.00
19.23
B
C


ATOM
14487
CB
PHE
B
385
42.336
16.521
−27.964
1.00
19.77
B
C


ATOM
14490
CG
PHE
B
385
43.757
16.714
−27.473
1.00
20.37
B
C


ATOM
14491
CD1
PHE
B
385
44.639
17.573
−28.099
1.00
29.85
B
C


ATOM
14493
CE1
PHE
B
385
45.940
17.681
−27.665
1.00
22.48
B
C


ATOM
14495
CZ
PHE
B
385
46.382
16.924
−26.617
1.00
24.37
B
C


ATOM
14497
CE2
PHE
B
385
45.540
16.037
−26.022
1.00
19.74
B
C


ATOM
14499
CD2
PHE
B
385
44.238
15.934
−26.441
1.00
22.30
B
C


ATOM
14501
C
PHE
B
385
40.375
17.371
−29.231
1.00
19.10
B
C


ATOM
14502
O
PHE
B
385
40.352
17.236
−30.447
1.00
20.62
B
O


ATOM
14504
N
LEU
B
386
39.293
17.190
−28.487
1.00
20.82
B
N


ATOM
14505
CA
LEU
B
386
38.062
16.710
−29.088
1.00
19.64
B
C


ATOM
14507
CB
LEU
B
386
37.033
16.356
−28.010
1.00
17.81
B
C


ATOM
14510
CG
LEU
B
386
35.711
15.780
−28.547
1.00
24.89
B
C


ATOM
14512
CD1
LEU
B
386
35.866
14.382
−29.197
1.00
17.85
B
C


ATOM
14516
CD2
LEU
B
386
34.649
15.792
−27.450
1.00
13.88
B
C


ATOM
14520
C
LEU
B
386
37.531
17.758
−30.044
1.00
19.89
B
C


ATOM
14521
O
LEU
B
386
37.114
17.439
−31.142
1.00
22.28
B
O


ATOM
14523
N
GLN
B
387
37.561
19.018
−29.629
1.00
22.06
B
N


ATOM
14524
CA
GLN
B
387
37.101
20.123
−30.479
1.00
21.92
B
C


ATOM
14526
CB
GLN
B
387
37.163
21.490
−29.736
1.00
23.65
B
C


ATOM
14529
CG
GLN
B
387
36.756
22.718
−30.578
1.00
24.14
B
C


ATOM
14532
CD
GLN
B
387
35.325
22.625
−31.073
1.00
16.59
B
C


ATOM
14533
OE1
GLN
B
387
35.071
22.082
−32.132
1.00
26.49
B
O


ATOM
14534
NE2
GLN
B
387
34.397
23.060
−30.270
1.00
21.29
B
N


ATOM
14537
C
GLN
B
387
37.902
20.163
−31.769
1.00
20.75
B
C


ATOM
14538
O
GLN
B
387
37.326
20.380
−32.815
1.00
21.62
B
O


ATOM
14540
N
GLU
B
388
39.211
19.914
−31.714
1.00
21.58
B
N


ATOM
14541
CA
GLU
B
388
40.045
19.919
−32.920
1.00
22.44
B
C


ATOM
14543
CB
GLU
B
388
41.538
19.854
−32.588
1.00
25.28
B
C


ATOM
14546
CG
GLU
B
388
42.068
21.146
−31.939
1.00
32.65
B
C


ATOM
14549
CD
GLU
B
388
43.555
21.107
−31.568
1.00
35.29
B
C


ATOM
14550
OE1
GLU
B
388
44.121
20.004
−31.343
1.00
36.54
B
O


ATOM
14551
OE2
GLU
B
388
44.158
22.197
−31.498
1.00
33.60
B
O


ATOM
14552
C
GLU
B
388
39.688
18.754
−33.825
1.00
21.97
B
C


ATOM
14553
O
GLU
B
388
39.651
18.903
−35.039
1.00
21.50
B
O


ATOM
14555
N
ALA
B
389
39.381
17.607
−33.236
1.00
21.26
B
N


ATOM
14556
CA
ALA
B
389
39.026
16.445
−34.048
1.00
21.14
B
C


ATOM
14558
CB
ALA
B
389
38.959
15.156
−33.221
1.00
20.09
B
C


ATOM
14562
C
ALA
B
389
37.707
16.691
−34.731
1.00
19.85
B
C


ATOM
14563
O
ALA
B
389
37.538
16.311
−35.875
1.00
20.01
B
O


ATOM
14565
N
LYS
B
390
36.771
17.324
−34.040
1.00
19.84
B
N


ATOM
14566
CA
LYS
B
390
35.453
17.575
−34.629
1.00
22.05
B
C


ATOM
14568
CB
LYS
B
390
34.455
18.051
−33.572
1.00
24.20
B
C


ATOM
14571
CG
LYS
B
390
33.969
17.003
−32.647
1.00
22.59
B
C


ATOM
14574
CD
LYS
B
390
32.947
17.600
−31.704
1.00
34.38
B
C


ATOM
14577
CE
LYS
B
390
32.409
16.563
−30.729
1.00
32.22
B
C


ATOM
14580
NZ
LYS
B
390
31.908
17.280
−29.517
1.00
30.01
B
N


ATOM
14584
C
LYS
B
390
35.491
18.607
−35.745
1.00
21.67
B
C


ATOM
14585
O
LYS
B
390
34.748
18.501
−36.709
1.00
21.81
B
O


ATOM
14587
N
TRP
B
391
36.349
19.609
−35.593
1.00
22.17
B
N


ATOM
14588
CA
TRP
B
391
36.538
20.662
−36.605
1.00
22.08
B
C


ATOM
14590
CB
TRP
B
391
37.462
21.803
−36.091
1.00
20.61
B
C


ATOM
14593
CG
TRP
B
391
36.758
22.833
−35.264
1.00
21.47
B
C


ATOM
14594
CD1
TRP
B
391
35.444
23.170
−35.325
1.00
21.71
B
C


ATOM
14596
NE1
TRP
B
391
35.169
24.177
−34.438
1.00
25.90
B
N


ATOM
14598
CE2
TRP
B
391
36.322
24.519
−33.791
1.00
19.12
B
C


ATOM
14599
CD2
TRP
B
391
37.345
23.702
−34.295
1.00
20.50
B
C


ATOM
14600
CE3
TRP
B
391
38.639
23.845
−33.778
1.00
23.66
B
C


ATOM
14602
CZ3
TRP
B
391
38.860
24.792
−32.811
1.00
18.30
B
C


ATOM
14604
CH2
TRP
B
391
37.825
25.605
−32.338
1.00
18.94
B
C


ATOM
14606
CZ2
TRP
B
391
36.546
25.480
−32.804
1.00
20.38
B
C


ATOM
14608
C
TRP
B
391
37.132
20.090
−37.860
1.00
22.57
B
C


ATOM
14609
O
TRP
B
391
36.765
20.495
−38.976
1.00
18.85
B
O


ATOM
14611
N
LEU
B
392
38.089
19.189
−37.676
1.00
23.55
B
N


ATOM
14612
CA
LEU
B
392
38.703
18.505
−38.812
1.00
27.40
B
C


ATOM
14614
CB
LEU
B
392
39.929
17.704
−38.359
1.00
28.77
B
C


ATOM
14617
CG
LEU
B
392
40.742
17.113
−39.517
1.00
37.78
B
C


ATOM
14619
CD1
LEU
B
392
41.420
18.237
−40.349
1.00
40.60
B
C


ATOM
14623
CD2
LEU
B
392
41.775
16.124
−38.979
1.00
38.73
B
C


ATOM
14627
C
LEU
B
392
37.674
17.591
−39.509
1.00
25.45
B
C


ATOM
14628
O
LEU
B
392
37.457
17.687
−40.714
1.00
24.87
B
O


ATOM
14630
N
TYR
B
393
36.998
16.748
−38.744
1.00
24.92
B
N


ATOM
14631
CA
TYR
B
393
35.977
15.878
−39.329
1.00
27.07
B
C


ATOM
14633
CB
TYR
B
393
35.261
15.065
−38.248
1.00
27.20
B
C


ATOM
14636
CG
TYR
B
393
34.250
14.084
−38.801
1.00
32.35
B
C


ATOM
14637
CD1
TYR
B
393
34.635
12.817
−39.240
1.00
36.10
B
C


ATOM
14639
CE1
TYR
B
393
33.685
11.915
−39.762
1.00
41.26
B
C


ATOM
14641
CZ
TYR
B
393
32.347
12.292
−39.829
1.00
42.05
B
C


ATOM
14642
OH
TYR
B
393
31.387
11.441
−40.331
1.00
49.85
B
O


ATOM
14644
CE2
TYR
B
393
31.959
13.542
−39.397
1.00
40.87
B
C


ATOM
14646
CD2
TYR
B
393
32.906
14.426
−38.890
1.00
37.12
B
C


ATOM
14648
C
TYR
B
393
34.940
16.684
−40.109
1.00
26.51
B
C


ATOM
14649
O
TYR
B
393
34.686
16.403
−41.270
1.00
26.33
B
O


ATOM
14651
N
ASN
B
394
34.341
17.685
−39.460
1.00
26.40
B
N


ATOM
14652
CA
ASN
B
394
33.277
18.486
−40.081
1.00
27.32
B
C


ATOM
14654
CB
ASN
B
394
32.442
19.175
−38.993
1.00
28.58
B
C


ATOM
14657
CG
ASN
B
394
31.679
18.176
−38.123
1.00
28.94
B
C


ATOM
14658
OD1
ASN
B
394
31.111
17.223
−38.628
1.00
34.61
B
O


ATOM
14659
ND2
ASN
B
394
31.632
18.420
−36.833
1.00
30.26
B
N


ATOM
14662
C
ASN
B
394
33.781
19.513
−41.110
1.00
27.48
B
C


ATOM
14663
O
ASN
B
394
32.997
20.225
−41.670
1.00
27.41
B
O


ATOM
14665
N
LYS
B
395
35.089
19.562
−41.372
1.00
29.77
B
N


ATOM
14666
CA
LYS
B
395
35.702
20.601
−42.222
1.00
31.41
B
C


ATOM
14668
CB
LYS
B
395
35.413
20.316
−43.699
1.00
33.28
B
C


ATOM
14671
CG
LYS
B
395
36.114
19.035
−44.217
1.00
41.09
B
C


ATOM
14674
CD
LYS
B
395
35.295
18.354
−45.321
1.00
50.28
B
C


ATOM
14677
CE
LYS
B
395
36.139
17.389
−46.164
1.00
54.00
B
C


ATOM
14680
NZ
LYS
B
395
36.929
16.446
−45.322
1.00
54.63
B
N


ATOM
14684
C
LYS
B
395
35.303
22.041
−41.811
1.00
31.59
B
C


ATOM
14685
O
LYS
B
395
35.164
22.939
−42.649
1.00
32.31
B
O


ATOM
14687
N
SER
B
396
35.137
22.249
−40.504
1.00
30.78
B
N


ATOM
14688
CA
SER
B
396
34.832
23.558
−39.971
1.00
29.21
B
C


ATOM
14690
CB
SER
B
396
34.656
23.475
−38.479
1.00
29.18
B
C


ATOM
14693
OG
SER
B
396
33.613
22.573
−38.184
1.00
28.88
B
O


ATOM
14695
C
SER
B
396
35.962
24.492
−40.327
1.00
28.15
B
C


ATOM
14696
O
SER
B
396
37.054
24.038
−40.604
1.00
30.53
B
O


ATOM
14698
N
THR
B
397
35.666
25.788
−40.360
1.00
26.95
B
N


ATOM
14699
CA
THR
B
397
36.617
26.847
−40.705
1.00
25.06
B
C


ATOM
14701
CB
THR
B
397
36.309
27.435
−42.117
1.00
27.07
B
C


ATOM
14703
OG1
THR
B
397
34.924
27.817
−42.180
1.00
25.75
B
O


ATOM
14705
CG2
THR
B
397
36.576
26.369
−43.218
1.00
27.27
B
C


ATOM
14709
C
THR
B
397
36.509
27.959
−39.641
1.00
24.96
B
C


ATOM
14710
O
THR
B
397
36.177
29.100
−39.937
1.00
24.56
B
O


ATOM
14712
N
PRO
B
398
36.791
27.622
−38.388
1.00
21.45
B
N


ATOM
14713
CA
PRO
B
398
36.633
28.604
−37.323
1.00
22.11
B
C


ATOM
14715
CB
PRO
B
398
37.058
27.831
−36.068
1.00
22.56
B
C


ATOM
14718
CG
PRO
B
398
37.975
26.737
−36.622
1.00
23.07
B
C


ATOM
14721
CD
PRO
B
398
37.438
26.379
−37.933
1.00
20.76
B
C


ATOM
14724
C
PRO
B
398
37.525
29.813
−37.478
1.00
19.82
B
C


ATOM
14725
O
PRO
B
398
38.602
29.720
−38.032
1.00
22.01
B
O


ATOM
14726
N
THR
B
399
37.093
30.930
−36.920
1.00
17.51
B
N


ATOM
14727
CA
THR
B
399
37.889
32.130
−36.915
1.00
15.86
B
C


ATOM
14729
CB
THR
B
399
37.165
33.304
−36.225
1.00
17.11
B
C


ATOM
14731
OG1
THR
B
399
37.060
32.998
−34.850
1.00
14.13
B
O


ATOM
14733
CG2
THR
B
399
35.717
33.586
−36.827
1.00
8.38
B
C


ATOM
14737
C
THR
B
399
39.152
31.912
−36.130
1.00
16.82
B
C


ATOM
14738
O
THR
B
399
39.258
30.995
−35.292
1.00
16.62
B
O


ATOM
14740
N
PHE
B
400
40.099
32.806
−36.356
1.00
17.90
B
N


ATOM
14741
CA
PHE
B
400
41.335
32.771
−35.628
1.00
20.04
B
C


ATOM
14743
CB
PHE
B
400
42.240
33.952
−35.999
1.00
19.33
B
C


ATOM
14746
CG
PHE
B
400
43.454
34.023
−35.144
1.00
22.23
B
C


ATOM
14747
CD1
PHE
B
400
44.521
33.161
−35.374
1.00
25.77
B
C


ATOM
14749
CE1
PHE
B
400
45.663
33.194
−34.559
1.00
23.21
B
C


ATOM
14751
CZ
PHE
B
400
45.721
34.093
−33.485
1.00
22.27
B
C


ATOM
14753
CE2
PHE
B
400
44.655
34.955
−33.244
1.00
24.82
B
C


ATOM
14755
CD2
PHE
B
400
43.524
34.914
−34.075
1.00
25.67
B
C


ATOM
14757
C
PHE
B
400
41.113
32.770
−34.120
1.00
20.59
B
C


ATOM
14758
O
PHE
B
400
41.692
31.965
−33.427
1.00
19.12
B
O


ATOM
14760
N
ASP
B
401
40.339
33.726
−33.612
1.00
19.68
B
N


ATOM
14761
CA
ASP
B
401
40.065
33.780
−32.186
1.00
20.55
B
C


ATOM
14763
CB
ASP
B
401
39.100
34.942
−31.855
1.00
19.50
B
C


ATOM
14766
CG
ASP
B
401
39.771
36.314
−31.977
1.00
26.06
B
C


ATOM
14767
OD1
ASP
B
401
41.024
36.425
−31.871
1.00
27.25
B
O


ATOM
14768
OD2
ASP
B
401
39.040
37.283
−32.190
1.00
31.85
B
O


ATOM
14769
C
ASP
B
401
39.518
32.467
−31.609
1.00
19.11
B
C


ATOM
14770
O
ASP
B
401
39.910
32.084
−30.525
1.00
15.67
B
O


ATOM
14772
N
ASP
B
402
38.582
31.816
−32.294
1.00
18.01
B
N


ATOM
14773
CA
ASP
B
402
38.058
30.539
−31.800
1.00
20.72
B
C


ATOM
14775
CB
ASP
B
402
36.784
30.151
−32.556
1.00
21.12
B
C


ATOM
14778
CG
ASP
B
402
35.608
31.018
−32.192
1.00
24.45
B
C


ATOM
14779
OD1
ASP
B
402
35.626
31.614
−31.100
1.00
34.43
B
O


ATOM
14780
OD2
ASP
B
402
34.655
31.099
−32.986
1.00
33.91
B
O


ATOM
14781
C
ASP
B
402
39.102
29.413
−31.902
1.00
20.64
B
C


ATOM
14782
O
ASP
B
402
39.301
28.658
−30.946
1.00
20.80
B
O


ATOM
14784
N
TYR
B
403
39.796
29.322
−33.037
1.00
17.89
B
N


ATOM
14785
CA
TYR
B
403
40.782
28.278
−33.195
1.00
20.95
B
C


ATOM
14787
CB
TYR
B
403
41.398
28.285
−34.593
1.00
24.16
B
C


ATOM
14790
CG
TYR
B
403
42.415
27.191
−34.774
1.00
25.07
B
C


ATOM
14791
CD1
TYR
B
403
41.994
25.920
−35.085
1.00
33.87
B
C


ATOM
14793
CE1
TYR
B
403
42.869
24.897
−35.245
1.00
36.88
B
C


ATOM
14795
CZ
TYR
B
403
44.210
25.112
−35.091
1.00
36.98
B
C


ATOM
14796
OH
TYR
B
403
45.014
24.010
−35.296
1.00
43.37
B
O


ATOM
14798
CE2
TYR
B
403
44.688
26.381
−34.763
1.00
35.63
B
C


ATOM
14800
CD2
TYR
B
403
43.772
27.416
−34.602
1.00
28.89
B
C


ATOM
14802
C
TYR
B
403
41.897
28.421
−32.195
1.00
20.62
B
C


ATOM
14803
O
TYR
B
403
42.306
27.462
−31.567
1.00
21.48
B
O


ATOM
14805
N
PHE
B
404
42.401
29.633
−32.053
1.00
21.49
B
N


ATOM
14806
CA
PHE
B
404
43.555
29.869
−31.181
1.00
21.36
B
C


ATOM
14808
CB
PHE
B
404
44.194
31.232
−31.479
1.00
20.72
B
C


ATOM
14811
CG
PHE
B
404
45.349
31.561
−30.618
1.00
18.53
B
C


ATOM
14812
CD1
PHE
B
404
46.497
30.774
−30.637
1.00
24.02
B
C


ATOM
14814
CE1
PHE
B
404
47.570
31.076
−29.822
1.00
19.40
B
C


ATOM
14816
CZ
PHE
B
404
47.510
32.189
−28.985
1.00
21.28
B
C


ATOM
14818
CE2
PHE
B
404
46.382
32.969
−28.957
1.00
24.12
B
C


ATOM
14820
CD2
PHE
B
404
45.306
32.658
−29.776
1.00
23.06
B
C


ATOM
14822
C
PHE
B
404
43.125
29.726
−29.740
1.00
21.63
B
C


ATOM
14823
O
PHE
B
404
43.825
29.110
−28.945
1.00
17.99
B
O


ATOM
14825
N
GLY
B
405
41.946
30.249
−29.399
1.00
22.47
B
N


ATOM
14826
CA
GLY
B
405
41.436
30.071
−28.039
1.00
22.00
B
C


ATOM
14829
C
GLY
B
405
41.509
28.604
−27.605
1.00
23.01
B
C


ATOM
14830
O
GLY
B
405
41.945
28.286
−26.503
1.00
25.26
B
O


ATOM
14832
N
ASN
B
406
41.049
27.711
−28.474
1.00
21.92
B
N


ATOM
14833
CA
ASN
B
406
41.158
26.281
−28.253
1.00
21.40
B
C


ATOM
14835
CB
ASN
B
406
40.293
25.515
−29.253
1.00
21.75
B
C


ATOM
14838
CG
ASN
B
406
40.155
24.061
−28.891
1.00
24.28
B
C


ATOM
14839
OD1
ASN
B
406
39.504
23.735
−27.911
1.00
22.62
B
O


ATOM
14840
ND2
ASN
B
406
40.776
23.176
−29.681
1.00
16.03
B
N


ATOM
14843
C
ASN
B
406
42.606
25.765
−28.361
1.00
20.04
B
C


ATOM
14844
O
ASN
B
406
43.029
24.937
−27.563
1.00
20.34
B
O


ATOM
14846
N
ALA
B
407
43.348
26.236
−29.353
1.00
18.11
B
N


ATOM
14847
CA
ALA
B
407
44.675
25.668
−29.610
1.00
19.56
B
C


ATOM
14849
CB
ALA
B
407
45.224
26.153
−30.939
1.00
16.25
B
C


ATOM
14853
C
ALA
B
407
45.701
25.884
−28.493
1.00
20.02
B
C


ATOM
14854
O
ALA
B
407
46.604
25.031
−28.294
1.00
20.33
B
O


ATOM
14856
N
TRP
B
408
45.611
27.007
−27.782
1.00
18.45
B
N


ATOM
14857
CA
TRP
B
408
46.564
27.232
−26.710
1.00
20.53
B
C


ATOM
14859
CB
TRP
B
408
46.737
28.706
−26.290
1.00
19.32
B
C


ATOM
14862
CG
TRP
B
408
45.544
29.473
−25.694
1.00
19.23
B
C


ATOM
14863
CD1
TRP
B
408
44.789
30.419
−26.330
1.00
22.29
B
C


ATOM
14865
NE1
TRP
B
408
43.833
30.934
−25.473
1.00
20.57
B
N


ATOM
14867
CE2
TRP
B
408
43.966
30.336
−24.257
1.00
21.54
B
C


ATOM
14868
CD2
TRP
B
408
45.052
29.418
−24.351
1.00
22.09
B
C


ATOM
14869
CE3
TRP
B
408
45.409
28.682
−23.214
1.00
22.59
B
C


ATOM
14871
CZ3
TRP
B
408
44.687
28.893
−22.028
1.00
23.88
B
C


ATOM
14873
CH2
TRP
B
408
43.606
29.809
−21.980
1.00
21.62
B
C


ATOM
14875
CZ2
TRP
B
408
43.244
30.540
−23.076
1.00
24.64
B
C


ATOM
14877
C
TRP
B
408
46.269
26.329
−25.543
1.00
20.19
B
C


ATOM
14878
O
TRP
B
408
47.159
26.031
−24.773
1.00
24.69
B
O


ATOM
14880
N
LYS
B
409
45.040
25.858
−25.431
1.00
19.87
B
N


ATOM
14881
CA
LYS
B
409
44.720
24.842
−24.443
1.00
20.66
B
C


ATOM
14883
CB
LYS
B
409
43.222
24.797
−24.163
1.00
18.56
B
C


ATOM
14886
CG
LYS
B
409
42.667
26.085
−23.503
1.00
25.88
B
C


ATOM
14889
CD
LYS
B
409
41.159
26.021
−23.179
1.00
33.24
B
C


ATOM
14892
CE
LYS
B
409
40.581
27.370
−22.701
1.00
37.85
B
C


ATOM
14895
NZ
LYS
B
409
40.211
28.350
−23.840
1.00
45.13
B
N


ATOM
14899
C
LYS
B
409
45.248
23.476
−24.902
1.00
20.55
B
C


ATOM
14900
O
LYS
B
409
45.859
22.746
−24.116
1.00
18.30
B
O


ATOM
14902
N
SER
B
410
45.068
23.178
−26.186
1.00
20.61
B
N


ATOM
14903
CA
SER
B
410
45.448
21.878
−26.756
1.00
20.11
B
C


ATOM
14905
CB
SER
B
410
44.882
21.701
−28.183
1.00
21.28
B
C


ATOM
14908
OG
SER
B
410
45.676
22.371
−29.177
1.00
18.53
B
O


ATOM
14910
C
SER
B
410
46.943
21.693
−26.827
1.00
21.39
B
C


ATOM
14911
O
SER
B
410
47.400
20.598
−27.087
1.00
21.38
B
O


ATOM
14913
N
SER
B
411
47.703
22.775
−26.667
1.00
22.35
B
N


ATOM
14914
CA
SER
B
411
49.155
22.694
−26.608
1.00
20.21
B
C


ATOM
14916
CB
SER
B
411
49.790
24.084
−26.486
1.00
21.74
B
C


ATOM
14919
OG
SER
B
411
49.520
24.719
−25.216
1.00
20.26
B
O


ATOM
14921
C
SER
B
411
49.584
21.872
−25.411
1.00
19.55
B
C


ATOM
14922
O
SER
B
411
50.645
21.322
−25.433
1.00
19.31
B
O


ATOM
14924
N
SER
B
412
48.738
21.814
−24.380
1.00
21.60
B
N


ATOM
14925
CA
SER
B
412
49.017
21.190
−23.068
1.00
22.15
B
C


ATOM
14927
CB
SER
B
412
49.701
19.819
−23.183
1.00
22.20
B
C


ATOM
14930
OG
SER
B
412
51.094
19.930
−23.403
1.00
20.47
B
O


ATOM
14932
C
SER
B
412
49.810
22.101
−22.119
1.00
21.31
B
C


ATOM
14933
O
SER
B
412
50.103
21.730
−20.970
1.00
21.57
B
O


ATOM
14935
N
GLY
B
413
50.107
23.308
−22.574
1.00
18.89
B
N


ATOM
14936
CA
GLY
B
413
50.807
24.295
−21.751
1.00
19.18
B
C


ATOM
14939
C
GLY
B
413
50.152
24.531
−20.408
1.00
19.27
B
C


ATOM
14940
O
GLY
B
413
50.809
24.440
−19.363
1.00
20.22
B
O


ATOM
14942
N
PRO
B
414
48.851
24.815
−20.412
1.00
17.74
B
N


ATOM
14943
CA
PRO
B
414
48.178
25.038
−19.143
1.00
20.20
B
C


ATOM
14945
CB
PRO
B
414
46.720
25.297
−19.567
1.00
20.76
B
C


ATOM
14948
CG
PRO
B
414
46.881
25.963
−20.871
1.00
16.96
B
C


ATOM
14951
CD
PRO
B
414
47.965
25.139
−21.537
1.00
18.57
B
C


ATOM
14954
C
PRO
B
414
48.247
23.840
−18.218
1.00
20.58
B
C


ATOM
14955
O
PRO
B
414
48.536
23.995
−17.047
1.00
20.97
B
O


ATOM
14956
N
LEU
B
415
48.005
22.654
−18.768
1.00
22.11
B
N


ATOM
14957
CA
LEU
B
415
48.040
21.432
−17.994
1.00
21.93
B
C


ATOM
14959
CB
LEU
B
415
47.677
20.224
−18.870
1.00
22.71
B
C


ATOM
14962
CG
LEU
B
415
47.827
18.842
−18.222
1.00
24.25
B
C


ATOM
14964
CD1
LEU
B
415
46.773
17.860
−18.751
1.00
21.18
B
C


ATOM
14968
CD2
LEU
B
415
49.234
18.290
−18.421
1.00
23.53
B
C


ATOM
14972
C
LEU
B
415
49.420
21.225
−17.393
1.00
22.23
B
C


ATOM
14973
O
LEU
B
415
49.540
20.955
−16.209
1.00
21.62
B
O


ATOM
14975
N
GLN
B
416
50.459
21.330
−18.214
1.00
21.75
B
N


ATOM
14976
CA
GLN
B
416
51.824
21.221
−17.701
1.00
20.58
B
C


ATOM
14978
CB
GLN
B
416
52.834
21.502
−18.790
1.00
19.97
B
C


ATOM
14981
CG
GLN
B
416
52.840
20.447
−19.842
1.00
19.48
B
C


ATOM
14984
CD
GLN
B
416
53.920
20.659
−20.837
1.00
26.66
B
C


ATOM
14985
OE1
GLN
B
416
55.002
21.132
−20.494
1.00
29.08
B
O


ATOM
14986
NE2
GLN
B
416
53.658
20.284
−22.089
1.00
24.07
B
N


ATOM
14989
C
GLN
B
416
52.062
22.162
−16.544
1.00
21.03
B
C


ATOM
14990
O
GLN
B
416
52.701
21.799
−15.558
1.00
23.28
B
O


ATOM
14992
N
LEU
B
417
51.545
23.374
−16.636
1.00
19.90
B
N


ATOM
14993
CA
LEU
B
417
51.878
24.340
−15.611
1.00
20.19
B
C


ATOM
14995
CB
LEU
B
417
51.770
25.766
−16.117
1.00
20.53
B
C


ATOM
14998
CG
LEU
B
417
52.799
26.171
−17.174
1.00
17.82
B
C


ATOM
15000
CD1
LEU
B
417
52.466
27.556
−17.758
1.00
18.27
B
C


ATOM
15004
CD2
LEU
B
417
54.219
26.142
−16.607
1.00
18.14
B
C


ATOM
15008
C
LEU
B
417
51.034
24.114
−14.371
1.00
20.73
B
C


ATOM
15009
O
LEU
B
417
51.472
24.460
−13.291
1.00
21.82
B
O


ATOM
15011
N
VAL
B
418
49.841
23.516
−14.500
1.00
21.29
B
N


ATOM
15012
CA
VAL
B
418
49.081
23.104
−13.310
1.00
20.26
B
C


ATOM
15014
CB
VAL
B
418
47.702
22.530
−13.655
1.00
21.33
B
C


ATOM
15016
CG1
VAL
B
418
46.715
23.671
−14.083
1.00
17.04
B
C


ATOM
15020
CG2
VAL
B
418
47.139
21.793
−12.468
1.00
19.19
B
C


ATOM
15024
C
VAL
B
418
49.929
22.077
−12.549
1.00
21.33
B
C


ATOM
15025
O
VAL
B
418
50.114
22.181
−11.350
1.00
21.65
B
O


ATOM
15027
N
PHE
B
419
50.498
21.125
−13.269
1.00
18.97
B
N


ATOM
15028
CA
PHE
B
419
51.345
20.140
−12.648
1.00
19.89
B
C


ATOM
15030
CB
PHE
B
419
51.657
19.015
−13.610
1.00
19.38
B
C


ATOM
15033
CG
PHE
B
419
50.563
17.967
−13.689
1.00
19.90
B
C


ATOM
15034
CD1
PHE
B
419
50.670
16.777
−12.971
1.00
18.98
B
C


ATOM
15036
CE1
PHE
B
419
49.668
15.827
−13.011
1.00
19.09
B
C


ATOM
15038
CZ
PHE
B
419
48.533
16.046
−13.802
1.00
20.18
B
C


ATOM
15040
CE2
PHE
B
419
48.424
17.216
−14.534
1.00
18.86
B
C


ATOM
15042
CD2
PHE
B
419
49.436
18.178
−14.460
1.00
17.01
B
C


ATOM
15044
C
PHE
B
419
52.620
20.762
−12.087
1.00
20.16
B
C


ATOM
15045
O
PHE
B
419
53.021
20.417
−10.991
1.00
20.38
B
O


ATOM
15047
N
ALA
B
420
53.239
21.684
−12.812
1.00
20.42
B
N


ATOM
15048
CA
ALA
B
420
54.427
22.338
−12.289
1.00
23.24
B
C


ATOM
15050
CB
ALA
B
420
55.062
23.322
−13.324
1.00
21.28
B
C


ATOM
15054
C
ALA
B
420
54.061
23.045
−10.988
1.00
24.47
B
C


ATOM
15055
O
ALA
B
420
54.800
22.943
−10.007
1.00
25.28
B
O


ATOM
15057
N
TYR
B
421
52.889
23.683
−10.947
1.00
24.54
B
N


ATOM
15058
CA
TYR
B
421
52.478
24.429
−9.753
1.00
23.69
B
C


ATOM
15060
CB
TYR
B
421
51.039
24.958
−9.879
1.00
23.32
B
C


ATOM
15063
CG
TYR
B
421
50.497
25.608
−8.616
1.00
24.00
B
C


ATOM
15064
CD1
TYR
B
421
50.904
26.885
−8.220
1.00
27.39
B
C


ATOM
15066
CE1
TYR
B
421
50.418
27.466
−7.053
1.00
26.70
B
C


ATOM
15068
CZ
TYR
B
421
49.527
26.759
−6.268
1.00
27.74
B
C


ATOM
15069
OH
TYR
B
421
49.003
27.300
−5.109
1.00
29.86
B
O


ATOM
15071
CE2
TYR
B
421
49.129
25.503
−6.642
1.00
26.17
B
C


ATOM
15073
CD2
TYR
B
421
49.616
24.931
−7.797
1.00
28.12
B
C


ATOM
15075
C
TYR
B
421
52.618
23.546
−8.524
1.00
25.70
B
C


ATOM
15076
O
TYR
B
421
53.296
23.894
−7.553
1.00
25.07
B
O


ATOM
15078
N
PHE
B
422
52.001
22.374
−8.560
1.00
26.45
B
N


ATOM
15079
CA
PHE
B
422
51.998
21.538
−7.363
1.00
23.99
B
C


ATOM
15081
CB
PHE
B
422
50.959
20.448
−7.476
1.00
23.45
B
C


ATOM
15084
CG
PHE
B
422
49.564
20.962
−7.545
1.00
21.76
B
C


ATOM
15085
CD1
PHE
B
422
48.963
21.499
−6.425
1.00
22.67
B
C


ATOM
15087
CE1
PHE
B
422
47.677
21.970
−6.487
1.00
22.09
B
C


ATOM
15089
CZ
PHE
B
422
46.996
21.931
−7.682
1.00
23.94
B
C


ATOM
15091
CE2
PHE
B
422
47.594
21.400
−8.798
1.00
24.20
B
C


ATOM
15093
CD2
PHE
B
422
48.852
20.905
−8.722
1.00
21.31
B
C


ATOM
15095
C
PHE
B
422
53.386
20.973
−7.060
1.00
25.00
B
C


ATOM
15096
O
PHE
B
422
53.687
20.659
−5.916
1.00
27.56
B
O


ATOM
15098
N
ALA
B
423
54.245
20.878
−8.067
1.00
24.59
B
N


ATOM
15099
CA
ALA
B
423
55.591
20.352
−7.857
1.00
24.37
B
C


ATOM
15101
CB
ALA
B
423
56.065
19.705
−9.117
1.00
21.00
B
C


ATOM
15105
C
ALA
B
423
56.647
21.370
−7.363
1.00
26.64
B
C


ATOM
15106
O
ALA
B
423
57.710
20.965
−6.870
1.00
30.03
B
O


ATOM
15108
N
VAL
B
424
56.397
22.664
−7.547
1.00
27.57
B
N


ATOM
15109
CA
VAL
B
424
57.351
23.700
−7.160
1.00
29.54
B
C


ATOM
15111
CB
VAL
B
424
57.704
24.619
−8.341
1.00
29.56
B
C


ATOM
15113
CG1
VAL
B
424
58.149
23.780
−9.552
1.00
26.25
B
C


ATOM
15117
CG2
VAL
B
424
56.527
25.557
−8.684
1.00
22.59
B
C


ATOM
15121
C
VAL
B
424
56.887
24.597
−6.011
1.00
32.82
B
C


ATOM
15122
O
VAL
B
424
57.704
25.262
−5.422
1.00
34.23
B
O


ATOM
15124
N
VAL
B
425
55.593
24.633
−5.713
1.00
34.79
B
N


ATOM
15125
CA
VAL
B
425
55.076
25.505
−4.675
1.00
38.89
B
C


ATOM
15127
CB
VAL
B
425
53.717
26.073
−5.071
1.00
39.09
B
C


ATOM
15129
CG1
VAL
B
425
53.005
26.649
−3.867
1.00
38.93
B
C


ATOM
15133
CG2
VAL
B
425
53.911
27.138
−6.142
1.00
37.94
B
C


ATOM
15137
C
VAL
B
425
54.946
24.779
−3.343
1.00
43.65
B
C


ATOM
15138
O
VAL
B
425
54.204
23.803
−3.242
1.00
45.04
B
O


ATOM
15140
N
GLN
B
426
55.647
25.279
−2.322
1.00
47.45
B
N


ATOM
15141
CA
GLN
B
426
55.676
24.630
−1.008
1.00
50.46
B
C


ATOM
15143
CB
GLN
B
426
56.627
25.368
−0.053
1.00
53.33
B
C


ATOM
15146
CG
GLN
B
426
58.129
25.084
−0.275
1.00
61.88
B
C


ATOM
15149
CD
GLN
B
426
59.034
25.792
0.746
1.00
68.89
B
C


ATOM
15150
OE1
GLN
B
426
59.973
26.503
0.376
1.00
73.47
B
O


ATOM
15151
NE2
GLN
B
426
58.742
25.602
2.034
1.00
69.40
B
N


ATOM
15154
C
GLN
B
426
54.285
24.519
−0.377
1.00
48.54
B
C


ATOM
15155
O
GLN
B
426
53.887
23.437
0.037
1.00
49.02
B
O


ATOM
15157
N
ASN
B
427
53.554
25.633
−0.316
1.00
46.21
B
N


ATOM
15158
CA
ASN
B
427
52.232
25.673
0.318
1.00
44.18
B
C


ATOM
15160
CB
ASN
B
427
52.271
26.578
1.552
1.00
45.10
B
C


ATOM
15163
CG
ASN
B
427
53.065
25.963
2.691
1.00
46.27
B
C


ATOM
15164
OD1
ASN
B
427
52.520
25.213
3.510
1.00
43.08
B
O


ATOM
15165
ND2
ASN
B
427
54.366
26.235
2.717
1.00
38.93
B
N


ATOM
15168
C
ASN
B
427
51.156
26.170
−0.631
1.00
42.56
B
C


ATOM
15169
O
ASN
B
427
51.127
27.352
−0.981
1.00
42.40
B
O


ATOM
15171
N
ILE
B
428
50.256
25.276
−1.024
1.00
40.21
B
N


ATOM
15172
CA
ILE
B
428
49.250
25.617
−2.008
1.00
40.37
B
C


ATOM
15174
CB
ILE
B
428
48.597
24.364
−2.634
1.00
41.28
B
C


ATOM
15176
CG1
ILE
B
428
47.742
23.600
−1.630
1.00
40.63
B
C


ATOM
15179
CD1
ILE
B
428
46.969
22.501
−2.264
1.00
38.48
B
C


ATOM
15183
CG2
ILE
B
428
49.675
23.424
−3.196
1.00
43.55
B
C


ATOM
15187
C
ILE
B
428
48.200
26.516
−1.391
1.00
40.76
B
C


ATOM
15188
O
ILE
B
428
47.902
26.395
−0.201
1.00
41.46
B
O


ATOM
15190
N
LYS
B
429
47.657
27.422
−2.198
1.00
39.80
B
N


ATOM
15191
CA
LYS
B
429
46.602
28.323
−1.759
1.00
39.22
B
C


ATOM
15193
CB
LYS
B
429
47.071
29.776
−1.808
1.00
39.67
B
C


ATOM
15196
CG
LYS
B
429
48.269
30.048
−0.920
1.00
45.60
B
C


ATOM
15199
CD
LYS
B
429
48.879
31.429
−1.157
1.00
50.03
B
C


ATOM
15202
CE
LYS
B
429
50.249
31.534
−0.469
1.00
53.38
B
C


ATOM
15205
NZ
LYS
B
429
50.713
32.937
−0.367
1.00
55.16
B
N


ATOM
15209
C
LYS
B
429
45.389
28.158
−2.637
1.00
38.88
B
C


ATOM
15210
O
LYS
B
429
45.492
27.998
−3.854
1.00
37.10
B
O


ATOM
15212
N
LYS
B
430
44.229
28.230
−2.007
1.00
40.34
B
N


ATOM
15213
CA
LYS
B
430
42.985
27.967
−2.682
1.00
41.57
B
C


ATOM
15215
CB
LYS
B
430
41.820
28.099
−1.691
1.00
44.11
B
C


ATOM
15218
CG
LYS
B
430
40.448
27.690
−2.234
1.00
52.05
B
C


ATOM
15221
CD
LYS
B
430
39.363
27.760
−1.142
1.00
63.27
B
C


ATOM
15224
CE
LYS
B
430
38.943
29.200
−0.822
1.00
67.72
B
C


ATOM
15227
NZ
LYS
B
430
38.124
29.784
−1.928
1.00
71.21
B
N


ATOM
15231
C
LYS
B
430
42.802
28.927
−3.843
1.00
39.97
B
C


ATOM
15232
O
LYS
B
430
42.358
28.523
−4.913
1.00
39.98
B
O


ATOM
15234
N
GLU
B
431
43.130
30.198
−3.639
1.00
39.37
B
N


ATOM
15235
CA
GLU
B
431
42.843
31.191
−4.666
1.00
39.18
B
C


ATOM
15237
CB
GLU
B
431
42.743
32.612
−4.088
1.00
40.15
B
C


ATOM
15240
CG
GLU
B
431
44.049
33.364
−3.837
1.00
50.24
B
C


ATOM
15243
CD
GLU
B
431
43.829
34.872
−3.580
1.00
60.38
B
C


ATOM
15244
OE1
GLU
B
431
43.114
35.532
−4.376
1.00
62.25
B
O


ATOM
15245
OE2
GLU
B
431
44.376
35.396
−2.582
1.00
62.66
B
O


ATOM
15246
C
GLU
B
431
43.813
31.070
−5.848
1.00
35.93
B
C


ATOM
15247
O
GLU
B
431
43.442
31.367
−6.982
1.00
34.81
B
O


ATOM
15249
N
GLU
B
432
45.034
30.618
−5.585
1.00
33.41
B
N


ATOM
15250
CA
GLU
B
432
45.965
30.298
−6.660
1.00
33.72
B
C


ATOM
15252
CB
GLU
B
432
47.353
29.955
−6.109
1.00
33.21
B
C


ATOM
15255
CG
GLU
B
432
48.085
31.141
−5.456
1.00
32.22
B
C


ATOM
15258
CD
GLU
B
432
49.493
30.803
−4.956
1.00
37.75
B
C


ATOM
15259
OE1
GLU
B
432
49.791
29.622
−4.631
1.00
34.91
B
O


ATOM
15260
OE2
GLU
B
432
50.317
31.745
−4.883
1.00
45.57
B
O


ATOM
15261
C
GLU
B
432
45.406
29.146
−7.507
1.00
33.26
B
C


ATOM
15262
O
GLU
B
432
45.304
29.260
−8.728
1.00
34.10
B
O


ATOM
15264
N
ILE
B
433
44.992
28.056
−6.873
1.00
33.07
B
N


ATOM
15265
CA
ILE
B
433
44.509
26.923
−7.661
1.00
34.77
B
C


ATOM
15267
CB
ILE
B
433
44.529
25.571
−6.921
1.00
33.31
B
C


ATOM
15269
CG1
ILE
B
433
43.828
25.602
−5.594
1.00
39.69
B
C


ATOM
15272
CD1
ILE
B
433
44.565
24.744
−4.570
1.00
40.72
B
C


ATOM
15276
CG2
ILE
B
433
45.949
25.194
−6.576
1.00
37.35
B
C


ATOM
15280
C
ILE
B
433
43.190
27.234
−8.334
1.00
33.17
B
C


ATOM
15281
O
ILE
B
433
42.938
26.745
−9.419
1.00
34.85
B
O


ATOM
15283
N
GLU
B
434
42.384
28.100
−7.750
1.00
31.81
B
N


ATOM
15284
CA
GLU
B
434
41.167
28.532
−8.428
1.00
33.28
B
C


ATOM
15286
CB
GLU
B
434
40.259
29.351
−7.499
1.00
36.58
B
C


ATOM
15289
CG
GLU
B
434
39.295
28.482
−6.669
1.00
45.80
B
C


ATOM
15292
CD
GLU
B
434
38.349
29.297
−5.797
1.00
58.22
B
C


ATOM
15293
OE1
GLU
B
434
38.744
30.392
−5.318
1.00
61.60
B
O


ATOM
15294
OE2
GLU
B
434
37.204
28.834
−5.597
1.00
62.57
B
O


ATOM
15295
C
GLU
B
434
41.470
29.333
−9.681
1.00
31.01
B
C


ATOM
15296
O
GLU
B
434
40.724
29.260
−10.669
1.00
32.01
B
O


ATOM
15298
N
ASN
B
435
42.546
30.108
−9.641
1.00
27.38
B
N


ATOM
15299
CA
ASN
B
435
42.931
30.894
−10.794
1.00
28.08
B
C


ATOM
15301
CB
ASN
B
435
43.789
32.084
−10.362
1.00
28.78
B
C


ATOM
15304
CG
ASN
B
435
42.934
33.315
−10.028
1.00
32.39
B
C


ATOM
15305
OD1
ASN
B
435
42.351
33.953
−10.913
1.00
39.25
B
O


ATOM
15306
ND2
ASN
B
435
42.835
33.621
−8.761
1.00
27.21
B
N


ATOM
15309
C
ASN
B
435
43.603
30.038
−11.878
1.00
27.27
B
C


ATOM
15310
O
ASN
B
435
43.453
30.315
−13.060
1.00
28.23
B
O


ATOM
15312
N
LEU
B
436
44.310
28.984
−11.483
1.00
27.03
B
N


ATOM
15313
CA
LEU
B
436
44.817
28.023
−12.463
1.00
28.24
B
C


ATOM
15315
CB
LEU
B
436
45.623
26.891
−11.820
1.00
27.45
B
C


ATOM
15318
CG
LEU
B
436
46.900
27.257
−11.062
1.00
26.99
B
C


ATOM
15320
CD1
LEU
B
436
47.517
26.029
−10.392
1.00
25.59
B
C


ATOM
15324
CD2
LEU
B
436
47.879
27.938
−11.979
1.00
26.36
B
C


ATOM
15328
C
LEU
B
436
43.639
27.442
−13.231
1.00
29.56
B
C


ATOM
15329
O
LEU
B
436
43.671
27.408
−14.445
1.00
30.09
B
O


ATOM
15331
N
GLN
B
437
42.577
27.034
−12.535
1.00
32.04
B
N


ATOM
15332
CA
GLN
B
437
41.444
26.395
−13.212
1.00
33.09
B
C


ATOM
15334
CB
GLN
B
437
40.418
25.838
−12.226
1.00
34.27
B
C


ATOM
15337
CG
GLN
B
437
40.927
24.764
−11.314
1.00
38.74
B
C


ATOM
15340
CD
GLN
B
437
39.827
23.808
−10.859
1.00
42.01
B
C


ATOM
15341
OE1
GLN
B
437
39.776
22.664
−11.304
1.00
38.35
B
O


ATOM
15342
NE2
GLN
B
437
38.949
24.275
−9.971
1.00
34.39
B
N


ATOM
15345
C
GLN
B
437
40.736
27.365
−14.137
1.00
32.68
B
C


ATOM
15346
O
GLN
B
437
40.030
26.933
−15.041
1.00
33.51
B
O


ATOM
15348
N
LYS
B
438
40.886
28.663
−13.893
1.00
31.93
B
N


ATOM
15349
CA
LYS
B
438
40.284
29.683
−14.765
1.00
34.40
B
C


ATOM
15351
CB
LYS
B
438
39.717
30.835
−13.933
1.00
36.15
B
C


ATOM
15354
CG
LYS
B
438
38.461
30.443
−13.155
1.00
46.92
B
C


ATOM
15357
CD
LYS
B
438
38.218
31.319
−11.915
1.00
56.20
B
C


ATOM
15360
CE
LYS
B
438
36.928
30.868
−11.170
1.00
62.26
B
C


ATOM
15363
NZ
LYS
B
438
36.666
31.585
−9.878
1.00
59.98
B
N


ATOM
15367
C
LYS
B
438
41.268
30.207
−15.810
1.00
31.95
B
C


ATOM
15368
O
LYS
B
438
40.973
31.152
−16.523
1.00
34.95
B
O


ATOM
15370
N
TYR
B
439
42.429
29.584
−15.901
1.00
30.59
B
N


ATOM
15371
CA
TYR
B
439
43.454
29.951
−16.874
1.00
31.05
B
C


ATOM
15373
CB
TYR
B
439
42.995
29.728
−18.308
1.00
31.76
B
C


ATOM
15376
CG
TYR
B
439
42.559
28.327
−18.592
1.00
35.31
B
C


ATOM
15377
CD1
TYR
B
439
43.486
27.367
−18.911
1.00
31.89
B
C


ATOM
15379
CE1
TYR
B
439
43.110
26.094
−19.190
1.00
44.43
B
C


ATOM
15381
CZ
TYR
B
439
41.785
25.748
−19.147
1.00
43.22
B
C


ATOM
15382
OH
TYR
B
439
41.462
24.467
−19.437
1.00
43.75
B
O


ATOM
15384
CE2
TYR
B
439
40.808
26.685
−18.827
1.00
40.92
B
C


ATOM
15386
CD2
TYR
B
439
41.202
27.970
−18.554
1.00
39.09
B
C


ATOM
15388
C
TYR
B
439
43.888
31.383
−16.714
1.00
29.52
B
C


ATOM
15389
O
TYR
B
439
43.889
32.157
−17.664
1.00
29.95
B
O


ATOM
15391
N
HIS
B
440
44.266
31.718
−15.493
1.00
29.00
B
N


ATOM
15392
CA
HIS
B
440
44.898
32.986
−15.198
1.00
27.83
B
C


ATOM
15394
CB
HIS
B
440
45.457
32.918
−13.782
1.00
27.70
B
C


ATOM
15397
CG
HIS
B
440
45.905
34.238
−13.250
1.00
34.45
B
C


ATOM
15398
ND1
HIS
B
440
47.203
34.688
−13.373
1.00
33.50
B
N


ATOM
15400
CE1
HIS
B
440
47.301
35.881
−12.815
1.00
35.67
B
C


ATOM
15402
NE2
HIS
B
440
46.117
36.217
−12.336
1.00
38.29
B
N


ATOM
15404
CD2
HIS
B
440
45.226
35.208
−12.599
1.00
32.67
B
C


ATOM
15406
C
HIS
B
440
46.052
33.277
−16.167
1.00
27.83
B
C


ATOM
15407
O
HIS
B
440
46.792
32.364
−16.577
1.00
23.95
B
O


ATOM
15409
N
ASP
B
441
46.206
34.557
−16.499
1.00
27.43
B
N


ATOM
15410
CA
ASP
B
441
47.296
35.072
−17.343
1.00
25.55
B
C


ATOM
15412
CB
ASP
B
441
47.448
36.575
−17.122
1.00
26.88
B
C


ATOM
15415
CG
ASP
B
441
46.214
37.382
−17.555
1.00
32.29
B
C


ATOM
15416
OD1
ASP
B
441
45.520
36.981
−18.519
1.00
32.54
B
O


ATOM
15417
OD2
ASP
B
441
45.947
38.424
−16.910
1.00
38.34
B
O


ATOM
15418
C
ASP
B
441
48.665
34.427
−17.077
1.00
25.73
B
C


ATOM
15419
O
ASP
B
441
49.455
34.247
−18.009
1.00
26.54
B
O


ATOM
15421
N
THR
B
442
48.956
34.084
−15.822
1.00
24.23
B
N


ATOM
15422
CA
THR
B
442
50.254
33.441
−15.475
1.00
25.82
B
C


ATOM
15424
CB
THR
B
442
50.317
33.025
−13.995
1.00
26.22
B
C


ATOM
15426
OG1
THR
B
442
50.066
34.173
−13.192
1.00
32.69
B
O


ATOM
15428
CG2
THR
B
442
51.692
32.497
−13.624
1.00
28.30
B
C


ATOM
15432
C
THR
B
442
50.562
32.211
−16.317
1.00
22.08
B
C


ATOM
15433
O
THR
B
442
51.699
31.994
−16.697
1.00
21.58
B
O


ATOM
15435
N
ILE
B
443
49.538
31.421
−16.605
1.00
22.63
B
N


ATOM
15436
CA
ILE
B
443
49.703
30.173
−17.329
1.00
21.27
B
C


ATOM
15438
CB
ILE
B
443
49.127
28.948
−16.523
1.00
21.12
B
C


ATOM
15440
CG1
ILE
B
443
47.612
28.928
−16.433
1.00
22.72
B
C


ATOM
15443
CD1
ILE
B
443
47.033
27.558
−15.846
1.00
18.38
B
C


ATOM
15447
CG2
ILE
B
443
49.685
28.915
−15.113
1.00
22.19
B
C


ATOM
15451
C
ILE
B
443
49.151
30.266
−18.751
1.00
21.71
B
C


ATOM
15452
O
ILE
B
443
49.603
29.544
−19.632
1.00
22.40
B
O


ATOM
15454
N
SER
B
444
48.220
31.189
−19.008
1.00
23.19
B
N


ATOM
15455
CA
SER
B
444
47.657
31.292
−20.344
1.00
21.64
B
C


ATOM
15457
CB
SER
B
444
46.339
32.028
−20.345
1.00
21.22
B
C


ATOM
15460
OG
SER
B
444
46.478
33.360
−19.936
1.00
26.99
B
O


ATOM
15462
C
SER
B
444
48.652
31.930
−21.295
1.00
22.27
B
C


ATOM
15463
O
SER
B
444
48.885
31.427
−22.399
1.00
25.52
B
O


ATOM
15465
N
ARG
B
445
49.293
33.001
−20.867
1.00
21.71
B
N


ATOM
15466
CA
ARG
B
445
50.158
33.724
−21.788
1.00
21.57
B
C


ATOM
15468
CB
ARG
B
445
50.571
35.066
−21.210
1.00
22.03
B
C


ATOM
15471
CG
ARG
B
445
49.356
35.981
−21.031
1.00
23.51
B
C


ATOM
15474
CD
ARG
B
445
49.746
37.392
−20.947
1.00
35.75
B
C


ATOM
15477
NE
ARG
B
445
48.625
38.263
−20.586
1.00
46.32
B
N


ATOM
15479
CZ
ARG
B
445
48.524
38.956
−19.448
1.00
42.95
B
C


ATOM
15480
NH1
ARG
B
445
49.463
38.885
−18.497
1.00
41.13
B
N


ATOM
15483
NH2
ARG
B
445
47.463
39.730
−19.261
1.00
41.39
B
N


ATOM
15486
C
ARG
B
445
51.341
32.921
−22.275
1.00
22.15
B
C


ATOM
15487
O
ARG
B
445
51.581
32.896
−23.460
1.00
21.06
B
O


ATOM
15489
N
PRO
B
446
52.064
32.233
−21.371
1.00
20.64
B
N


ATOM
15490
CA
PRO
B
446
53.093
31.345
−21.884
1.00
20.55
B
C


ATOM
15492
CB
PRO
B
446
53.766
30.765
−20.628
1.00
21.36
B
C


ATOM
15495
CG
PRO
B
446
53.127
31.394
−19.456
1.00
26.98
B
C


ATOM
15498
CD
PRO
B
446
52.065
32.353
−19.908
1.00
22.16
B
C


ATOM
15501
C
PRO
B
446
52.529
30.224
−22.761
1.00
19.46
B
C


ATOM
15502
O
PRO
B
446
53.196
29.757
−23.671
1.00
19.46
B
O


ATOM
15503
N
SER
B
447
51.316
29.781
−22.494
1.00
21.05
B
N


ATOM
15504
CA
SER
B
447
50.692
28.808
−23.397
1.00
21.90
B
C


ATOM
15506
CB
SER
B
447
49.439
28.196
−22.759
1.00
22.29
B
C


ATOM
15509
OG
SER
B
447
49.766
27.644
−21.480
1.00
23.50
B
O


ATOM
15511
C
SER
B
447
50.398
29.439
−24.765
1.00
20.46
B
C


ATOM
15512
O
SER
B
447
50.526
28.757
−25.772
1.00
18.99
B
O


ATOM
15514
N
HIS
B
448
50.065
30.736
−24.809
1.00
18.56
B
N


ATOM
15515
CA
HIS
B
448
49.869
31.424
−26.102
1.00
19.59
B
C


ATOM
15517
CB
HIS
B
448
49.575
32.940
−25.943
1.00
20.25
B
C


ATOM
15520
CG
HIS
B
448
48.262
33.260
−25.299
1.00
17.92
B
C


ATOM
15521
ND1
HIS
B
448
47.442
32.305
−24.739
1.00
28.87
B
N


ATOM
15523
CE1
HIS
B
448
46.352
32.881
−24.262
1.00
28.11
B
C


ATOM
15525
NE2
HIS
B
448
46.445
34.180
−24.475
1.00
27.76
B
N


ATOM
15527
CD2
HIS
B
448
47.635
34.443
−25.110
1.00
27.89
B
C


ATOM
15529
C
HIS
B
448
51.144
31.279
−26.940
1.00
20.44
B
C


ATOM
15530
O
HIS
B
448
51.091
30.897
−28.104
1.00
22.27
B
O


ATOM
15532
N
ILE
B
449
52.280
31.587
−26.330
1.00
21.15
B
N


ATOM
15533
CA
ILE
B
449
53.582
31.551
−26.989
1.00
22.39
B
C


ATOM
15535
CB
ILE
B
449
54.724
32.020
−26.038
1.00
24.30
B
C


ATOM
15537
CG1
ILE
B
449
54.491
33.446
−25.519
1.00
23.85
B
C


ATOM
15540
CD1
ILE
B
449
54.478
34.442
−26.532
1.00
25.54
B
C


ATOM
15544
CG2
ILE
B
449
56.112
31.942
−26.722
1.00
18.30
B
C


ATOM
15548
C
ILE
B
449
53.927
30.142
−27.449
1.00
22.56
B
C


ATOM
15549
O
ILE
B
449
54.427
29.944
−28.551
1.00
24.34
B
O


ATOM
15551
N
PHE
B
450
53.688
29.163
−26.586
1.00
23.02
B
N


ATOM
15552
CA
PHE
B
450
53.918
27.756
−26.916
1.00
21.54
B
C


ATOM
15554
CB
PHE
B
450
53.473
26.918
−25.716
1.00
23.75
B
C


ATOM
15557
CG
PHE
B
450
53.594
25.410
−25.887
1.00
24.61
B
C


ATOM
15558
CD1
PHE
B
450
54.374
24.827
−26.878
1.00
26.66
B
C


ATOM
15560
CE1
PHE
B
450
54.457
23.457
−26.978
1.00
27.03
B
C


ATOM
15562
CZ
PHE
B
450
53.801
22.643
−26.064
1.00
24.83
B
C


ATOM
15564
CE2
PHE
B
450
53.052
23.206
−25.056
1.00
28.16
B
C


ATOM
15566
CD2
PHE
B
450
52.960
24.581
−24.968
1.00
24.61
B
C


ATOM
15568
C
PHE
B
450
53.191
27.358
−28.205
1.00
20.99
B
C


ATOM
15569
O
PHE
B
450
53.819
26.924
−29.186
1.00
21.24
B
O


ATOM
15571
N
ARG
B
451
51.884
27.569
−28.229
1.00
19.94
B
N


ATOM
15572
CA
ARG
B
451
51.098
27.288
−29.420
1.00
20.74
B
C


ATOM
15574
CB
ARG
B
451
49.621
27.595
−29.169
1.00
22.47
B
C


ATOM
15577
CG
ARG
B
451
48.730
27.505
−30.419
1.00
25.35
B
C


ATOM
15580
CD
ARG
B
451
48.936
26.192
−31.191
1.00
23.31
B
C


ATOM
15583
NE
ARG
B
451
48.475
25.041
−30.448
1.00
19.56
B
N


ATOM
15585
CZ
ARG
B
451
48.731
23.772
−30.790
1.00
23.42
B
C


ATOM
15586
NH1
ARG
B
451
49.495
23.478
−31.840
1.00
19.04
B
N


ATOM
15589
NH2
ARG
B
451
48.232
22.788
−30.062
1.00
18.74
B
N


ATOM
15592
C
ARG
B
451
51.588
28.065
−30.632
1.00
19.72
B
C


ATOM
15593
O
ARG
B
451
51.806
27.489
−31.685
1.00
19.96
B
O


ATOM
15595
N
LEU
B
452
51.786
29.369
−30.495
1.00
21.57
B
N


ATOM
15596
CA
LEU
B
452
52.199
30.177
−31.659
1.00
20.99
B
C


ATOM
15598
CB
LEU
B
452
52.191
31.663
−31.330
1.00
18.72
B
C


ATOM
15601
CG
LEU
B
452
50.805
32.248
−31.082
1.00
18.91
B
C


ATOM
15603
CD1
LEU
B
452
50.863
33.633
−30.405
1.00
15.37
B
C


ATOM
15607
CD2
LEU
B
452
50.033
32.299
−32.401
1.00
22.45
B
C


ATOM
15611
C
LEU
B
452
53.557
29.757
−32.201
1.00
21.75
B
C


ATOM
15612
O
LEU
B
452
53.753
29.726
−33.427
1.00
24.82
B
O


ATOM
15614
N
CYS
B
453
54.513
29.472
−31.315
1.00
22.18
B
N


ATOM
15615
CA
CYS
B
453
55.844
29.031
−31.758
1.00
22.41
B
C


ATOM
15617
CB
CYS
B
453
56.801
28.918
−30.589
1.00
25.19
B
C


ATOM
15620
SG
CYS
B
453
57.373
30.478
−29.922
1.00
28.92
B
S


ATOM
15622
C
CYS
B
453
55.744
27.682
−32.476
1.00
23.45
B
C


ATOM
15623
O
CYS
B
453
56.283
27.514
−33.545
1.00
25.24
B
O


ATOM
15625
N
ASN
B
454
55.004
26.743
−31.901
1.00
23.96
B
N


ATOM
15626
CA
ASN
B
454
54.755
25.463
−32.555
1.00
25.23
B
C


ATOM
15628
CB
ASN
B
454
53.889
24.583
−31.643
1.00
25.52
B
C


ATOM
15631
CG
ASN
B
454
53.627
23.178
−32.218
1.00
30.70
B
C


ATOM
15632
OD1
ASN
B
454
54.124
22.811
−33.295
1.00
41.50
B
O


ATOM
15633
ND2
ASN
B
454
52.848
22.382
−31.480
1.00
30.45
B
N


ATOM
15636
C
ASN
B
454
54.103
25.614
−33.935
1.00
26.69
B
C


ATOM
15637
O
ASN
B
454
54.551
25.039
−34.924
1.00
25.94
B
O


ATOM
15639
N
ASP
B
455
53.039
26.393
−34.006
1.00
25.79
B
N


ATOM
15640
CA
ASP
B
455
52.334
26.528
−35.265
1.00
24.91
B
C


ATOM
15642
CB
ASP
B
455
50.983
27.213
−35.077
1.00
24.32
B
C


ATOM
15645
CG
ASP
B
455
49.932
26.296
−34.475
1.00
27.79
B
C


ATOM
15646
OD1
ASP
B
455
50.267
25.171
−34.053
1.00
23.64
B
O


ATOM
15647
OD2
ASP
B
455
48.753
26.715
−34.422
1.00
29.77
B
O


ATOM
15648
C
ASP
B
455
53.169
27.290
−36.278
1.00
25.89
B
C


ATOM
15649
O
ASP
B
455
53.081
27.002
−37.471
1.00
26.97
B
O


ATOM
15651
N
LEU
B
456
53.950
28.267
−35.829
1.00
25.05
B
N


ATOM
15652
CA
LEU
B
456
54.864
28.975
−36.734
1.00
27.30
B
C


ATOM
15654
CB
LEU
B
456
55.706
30.009
−35.981
1.00
28.50
B
C


ATOM
15657
CG
LEU
B
456
55.165
31.412
−35.754
1.00
31.82
B
C


ATOM
15659
CD1
LEU
B
456
56.033
32.147
−34.720
1.00
27.46
B
C


ATOM
15663
CD2
LEU
B
456
55.143
32.136
−37.066
1.00
27.67
B
C


ATOM
15667
C
LEU
B
456
55.831
27.999
−37.417
1.00
29.38
B
C


ATOM
15668
O
LEU
B
456
56.116
28.138
−38.610
1.00
27.77
B
O


ATOM
15670
N
ALA
B
457
56.332
27.022
−36.653
1.00
29.83
B
N


ATOM
15671
CA
ALA
B
457
57.349
26.087
−37.157
1.00
31.91
B
C


ATOM
15673
CB
ALA
B
457
58.006
25.277
−35.983
1.00
28.83
B
C


ATOM
15677
C
ALA
B
457
56.801
25.140
−38.232
1.00
32.51
B
C


ATOM
15678
O
ALA
B
457
57.519
24.802
−39.166
1.00
34.24
B
O


ATOM
15680
N
SER
B
458
55.541
24.723
−38.123
1.00
33.79
B
N


ATOM
15681
CA
SER
B
458
54.957
23.822
−39.135
1.00
34.87
B
C


ATOM
15683
CB
SER
B
458
54.113
22.751
−38.446
1.00
34.97
B
C


ATOM
15686
OG
SER
B
458
53.080
23.347
−37.693
1.00
39.44
B
O


ATOM
15688
C
SER
B
458
54.094
24.531
−40.189
1.00
33.97
B
C


ATOM
15689
O
SER
B
458
53.555
23.888
−41.097
1.00
34.54
B
O


ATOM
15691
N
ALA
B
459
53.951
25.845
−40.077
1.00
34.50
B
N


ATOM
15692
CA
ALA
B
459
52.971
26.580
−40.907
1.00
33.99
B
C


ATOM
15694
CB
ALA
B
459
53.033
28.075
−40.597
1.00
31.89
B
C


ATOM
15698
C
ALA
B
459
53.174
26.357
−42.408
1.00
35.22
B
C


ATOM
15699
O
ALA
B
459
52.247
25.966
−43.129
1.00
33.66
B
O


ATOM
15701
N
SER
B
460
54.386
26.616
−42.878
1.00
37.80
B
N


ATOM
15702
CA
SER
B
460
54.671
26.532
−44.308
1.00
42.19
B
C


ATOM
15704
CB
SER
B
460
56.131
26.863
−44.593
1.00
41.81
B
C


ATOM
15707
OG
SER
B
460
56.959
25.873
−44.007
1.00
52.01
B
O


ATOM
15709
C
SER
B
460
54.306
25.164
−44.903
1.00
42.35
B
C


ATOM
15710
O
SER
B
460
53.632
25.107
−45.925
1.00
43.43
B
O


ATOM
15712
N
ALA
B
461
54.718
24.073
−44.264
1.00
42.83
B
N


ATOM
15713
CA
ALA
B
461
54.384
22.738
−44.780
1.00
42.85
B
C


ATOM
15715
CB
ALA
B
461
55.110
21.645
−44.000
1.00
42.43
B
C


ATOM
15719
C
ALA
B
461
52.881
22.504
−44.737
1.00
43.66
B
C


ATOM
15720
O
ALA
B
461
52.300
22.003
−45.696
1.00
44.63
B
O


ATOM
15722
N
GLU
B
462
52.253
22.884
−43.627
1.00
43.99
B
N


ATOM
15723
CA
GLU
B
462
50.839
22.611
−43.422
1.00
43.23
B
C


ATOM
15725
CB
GLU
B
462
50.439
22.868
−41.960
1.00
43.40
B
C


ATOM
15728
CG
GLU
B
462
51.049
21.826
−40.996
1.00
44.25
B
C


ATOM
15731
CD
GLU
B
462
50.581
21.932
−39.541
1.00
47.19
B
C


ATOM
15732
OE1
GLU
B
462
49.667
22.724
−39.235
1.00
52.18
B
O


ATOM
15733
OE2
GLU
B
462
51.140
21.208
−38.685
1.00
50.84
B
O


ATOM
15734
C
GLU
B
462
49.979
23.397
−44.405
1.00
43.66
B
C


ATOM
15735
O
GLU
B
462
48.979
22.885
−44.919
1.00
43.54
B
O


ATOM
15737
N
ILE
B
463
50.388
24.624
−44.701
1.00
43.85
B
N


ATOM
15738
CA
ILE
B
463
49.678
25.443
−45.670
1.00
43.45
B
C


ATOM
15740
CB
ILE
B
463
50.147
26.910
−45.599
1.00
42.49
B
C


ATOM
15742
CG1
ILE
B
463
49.640
27.547
−44.298
1.00
43.11
B
C


ATOM
15745
CD1
ILE
B
463
50.272
28.903
−43.970
1.00
34.75
B
C


ATOM
15749
CG2
ILE
B
463
49.658
27.714
−46.809
1.00
40.80
B
C


ATOM
15753
C
ILE
B
463
49.836
24.863
−47.086
1.00
46.39
B
C


ATOM
15754
O
ILE
B
463
48.888
24.891
−47.885
1.00
48.52
B
O


ATOM
15756
N
ALA
B
464
51.016
24.324
−47.387
1.00
47.05
B
N


ATOM
15757
CA
ALA
B
464
51.302
23.784
−48.719
1.00
48.40
B
C


ATOM
15759
CB
ALA
B
464
52.809
23.523
−48.896
1.00
46.81
B
C


ATOM
15763
C
ALA
B
464
50.489
22.516
−48.985
1.00
49.19
B
C


ATOM
15764
O
ALA
B
464
50.121
22.260
−50.125
1.00
49.95
B
O


ATOM
15766
N
ARG
B
465
50.195
21.739
−47.941
1.00
49.76
B
N


ATOM
15767
CA
ARG
B
465
49.306
20.569
−48.075
1.00
51.15
B
C


ATOM
15769
CB
ARG
B
465
49.490
19.572
−46.925
1.00
51.61
B
C


ATOM
15772
CG
ARG
B
465
50.880
18.967
−46.767
1.00
55.53
B
C


ATOM
15775
CD
ARG
B
465
50.935
18.153
−45.476
1.00
58.91
B
C


ATOM
15778
NE
ARG
B
465
52.181
18.367
−44.734
1.00
65.49
B
N


ATOM
15780
CZ
ARG
B
465
52.308
18.305
−43.404
1.00
67.24
B
C


ATOM
15781
NH1
ARG
B
465
51.261
18.048
−42.620
1.00
67.28
B
N


ATOM
15784
NH2
ARG
B
465
53.500
18.517
−42.849
1.00
67.61
B
N


ATOM
15787
C
ARG
B
465
47.831
20.956
−48.095
1.00
51.06
B
C


ATOM
15788
O
ARG
B
465
46.971
20.082
−48.199
1.00
50.83
B
O


ATOM
15790
N
GLY
B
466
47.533
22.247
−47.958
1.00
50.91
B
N


ATOM
15791
CA
GLY
B
466
46.152
22.716
−47.896
1.00
50.39
B
C


ATOM
15794
C
GLY
B
466
45.486
22.489
−46.547
1.00
49.96
B
C


ATOM
15795
O
GLY
B
466
44.259
22.509
−46.466
1.00
48.27
B
O


ATOM
15797
N
GLU
B
467
46.279
22.272
−45.492
1.00
48.91
B
N


ATOM
15798
CA
GLU
B
467
45.730
22.134
−44.139
1.00
48.83
B
C


ATOM
15800
CB
GLU
B
467
46.683
21.365
−43.215
1.00
50.22
B
C


ATOM
15803
CG
GLU
B
467
46.967
19.930
−43.661
1.00
54.30
B
C


ATOM
15806
CD
GLU
B
467
47.790
19.116
−42.653
1.00
62.14
B
C


ATOM
15807
OE1
GLU
B
467
47.867
19.491
−41.458
1.00
59.06
B
O


ATOM
15808
OE2
GLU
B
467
48.354
18.078
−43.069
1.00
67.03
B
O


ATOM
15809
C
GLU
B
467
45.424
23.515
−43.548
1.00
47.13
B
C


ATOM
15810
O
GLU
B
467
46.114
24.497
−43.847
1.00
47.48
B
O


ATOM
15812
N
THR
B
468
44.375
23.586
−42.732
1.00
42.97
B
N


ATOM
15813
CA
THR
B
468
43.954
24.835
−42.125
1.00
40.67
B
C


ATOM
15815
CB
THR
B
468
42.508
25.173
−42.518
1.00
42.48
B
C


ATOM
15817
OG1
THR
B
468
41.661
24.045
−42.263
1.00
42.18
B
O


ATOM
15819
CG2
THR
B
468
42.418
25.574
−43.978
1.00
40.21
B
C


ATOM
15823
C
THR
B
468
44.074
24.847
−40.585
1.00
38.82
B
C


ATOM
15824
O
THR
B
468
43.912
25.902
−39.956
1.00
36.40
B
O


ATOM
15826
N
ALA
B
469
44.376
23.688
−39.996
1.00
36.08
B
N


ATOM
15827
CA
ALA
B
469
44.455
23.532
−38.542
1.00
35.79
B
C


ATOM
15829
CB
ALA
B
469
44.222
22.068
−38.167
1.00
35.44
B
C


ATOM
15833
C
ALA
B
469
45.812
24.041
−38.008
1.00
33.99
B
C


ATOM
15834
O
ALA
B
469
46.668
23.262
−37.602
1.00
35.58
B
O


ATOM
15836
N
ASN
B
470
45.972
25.363
−38.014
1.00
30.53
B
N


ATOM
15837
CA
ASN
B
470
47.231
26.025
−37.741
1.00
25.50
B
C


ATOM
15839
CB
ASN
B
470
48.175
25.826
−38.924
1.00
24.65
B
C


ATOM
15842
CG
ASN
B
470
49.538
26.437
−38.688
1.00
24.87
B
C


ATOM
15843
OD1
ASN
B
470
49.730
27.634
−38.868
1.00
29.42
B
O


ATOM
15844
ND2
ASN
B
470
50.501
25.609
−38.281
1.00
29.64
B
N


ATOM
15847
C
ASN
B
470
46.974
27.515
−37.559
1.00
24.47
B
C


ATOM
15848
O
ASN
B
470
46.291
28.128
−38.365
1.00
25.58
B
O


ATOM
15850
N
SER
B
471
47.564
28.104
−36.536
1.00
23.87
B
N


ATOM
15851
CA
SER
B
471
47.303
29.492
−36.181
1.00
22.68
B
C


ATOM
15853
CB
SER
B
471
48.100
29.848
−34.917
1.00
23.21
B
C


ATOM
15856
OG
SER
B
471
47.655
29.026
−33.835
1.00
25.29
B
O


ATOM
15858
C
SER
B
471
47.606
30.484
−37.296
1.00
22.53
B
C


ATOM
15859
O
SER
B
471
46.853
31.454
−37.500
1.00
18.89
B
O


ATOM
15861
N
VAL
B
472
48.692
30.241
−38.031
1.00
22.65
B
N


ATOM
15862
CA
VAL
B
472
49.105
31.147
−39.088
1.00
21.42
B
C


ATOM
15864
CB
VAL
B
472
50.518
30.828
−39.641
1.00
21.25
B
C


ATOM
15866
CG1
VAL
B
472
50.905
31.826
−40.704
1.00
17.98
B
C


ATOM
15870
CG2
VAL
B
472
51.546
30.823
−38.538
1.00
20.99
B
C


ATOM
15874
C
VAL
B
472
48.090
31.055
−40.204
1.00
21.80
B
C


ATOM
15875
O
VAL
B
472
47.694
32.062
−40.783
1.00
22.50
B
O


ATOM
15877
N
SER
B
473
47.659
29.841
−40.498
1.00
24.12
B
N


ATOM
15878
CA
SER
B
473
46.680
29.630
−41.544
1.00
25.40
B
C


ATOM
15880
CB
SER
B
473
46.400
28.146
−41.745
1.00
26.05
B
C


ATOM
15883
OG
SER
B
473
45.232
27.940
−42.515
1.00
32.34
B
O


ATOM
15885
C
SER
B
473
45.400
30.375
−41.202
1.00
24.34
B
C


ATOM
15886
O
SER
B
473
44.847
31.051
−42.064
1.00
23.63
B
O


ATOM
15888
N
CYS
B
474
44.921
30.280
−39.960
1.00
23.27
B
N


ATOM
15889
CA
CYS
B
474
43.642
30.961
−39.612
1.00
24.54
B
C


ATOM
15891
CB
CYS
B
474
43.162
30.643
−38.196
1.00
26.93
B
C


ATOM
15894
SG
CYS
B
474
42.488
29.053
−38.026
1.00
32.90
B
S


ATOM
15896
C
CYS
B
474
43.784
32.442
−39.678
1.00
22.35
B
C


ATOM
15897
O
CYS
B
474
42.866
33.138
−40.073
1.00
25.09
B
O


ATOM
15899
N
TYR
B
475
44.934
32.933
−39.257
1.00
21.83
B
N


ATOM
15900
CA
TYR
B
475
45.190
34.340
−39.332
1.00
22.48
B
C


ATOM
15902
CB
TYR
B
475
46.530
34.700
−38.700
1.00
21.91
B
C


ATOM
15905
CG
TYR
B
475
46.519
36.065
−38.080
1.00
23.95
B
C


ATOM
15906
CD1
TYR
B
475
46.386
36.237
−36.704
1.00
34.09
B
C


ATOM
15908
CE1
TYR
B
475
46.373
37.512
−36.136
1.00
35.55
B
C


ATOM
15910
CZ
TYR
B
475
46.497
38.611
−36.954
1.00
34.14
B
C


ATOM
15911
OH
TYR
B
475
46.491
39.895
−36.448
1.00
48.07
B
O


ATOM
15913
CE2
TYR
B
475
46.635
38.456
−38.307
1.00
35.92
B
C


ATOM
15915
CD2
TYR
B
475
46.644
37.188
−38.863
1.00
31.67
B
C


ATOM
15917
C
TYR
B
475
45.105
34.802
−40.780
1.00
22.81
B
C


ATOM
15918
O
TYR
B
475
44.474
35.831
−41.063
1.00
21.86
B
O


ATOM
15920
N
MET
B
476
45.690
34.038
−41.702
1.00
23.95
B
N


ATOM
15921
CA
MET
B
476
45.575
34.362
−43.138
1.00
23.98
B
C


ATOM
15923
CB
MET
B
476
46.227
33.304
−44.022
1.00
23.03
B
C


ATOM
15926
CG
MET
B
476
47.734
33.236
−43.917
1.00
31.57
B
C


ATOM
15929
SD
MET
B
476
48.370
31.791
−44.783
1.00
35.82
B
S


ATOM
15930
CE
MET
B
476
47.693
31.997
−46.420
1.00
24.22
B
C


ATOM
15934
C
MET
B
476
44.141
34.491
−43.607
1.00
23.68
B
C


ATOM
15935
O
MET
B
476
43.773
35.478
−44.264
1.00
22.64
B
O


ATOM
15937
N
ARG
B
477
43.345
33.465
−43.322
1.00
25.52
B
N


ATOM
15938
CA
ARG
B
477
41.970
33.395
−43.827
1.00
25.98
B
C


ATOM
15940
CB
ARG
B
477
41.428
31.967
−43.725
1.00
26.64
B
C


ATOM
15943
CG
ARG
B
477
42.138
31.022
−44.683
1.00
33.11
B
C


ATOM
15946
CD
ARG
B
477
41.835
29.543
−44.464
1.00
39.31
B
C


ATOM
15949
NE
ARG
B
477
42.179
29.067
−43.121
1.00
44.33
B
N


ATOM
15951
CZ
ARG
B
477
41.305
28.880
−42.129
1.00
46.94
B
C


ATOM
15952
NH1
ARG
B
477
40.009
29.127
−42.300
1.00
48.55
B
N


ATOM
15955
NH2
ARG
B
477
41.736
28.447
−40.947
1.00
49.68
B
N


ATOM
15958
C
ARG
B
477
41.058
34.367
−43.100
1.00
25.86
B
C


ATOM
15959
O
ARG
B
477
40.157
34.945
−43.720
1.00
28.90
B
O


ATOM
15961
N
THR
B
478
41.277
34.546
−41.797
1.00
24.19
B
N


ATOM
15962
CA
THR
B
478
40.461
35.474
−41.024
1.00
25.34
B
C


ATOM
15964
CB
THR
B
478
40.684
35.343
−39.479
1.00
25.12
B
C


ATOM
15966
OG1
THR
B
478
40.006
34.185
−38.996
1.00
20.79
B
O


ATOM
15968
CG2
THR
B
478
40.152
36.574
−38.707
1.00
21.35
B
C


ATOM
15972
C
THR
B
478
40.692
36.916
−41.477
1.00
25.19
B
C


ATOM
15973
O
THR
B
478
39.741
37.646
−41.606
1.00
24.19
B
O


ATOM
15975
N
LYS
B
479
41.944
37.316
−41.698
1.00
25.64
B
N


ATOM
15976
CA
LYS
B
479
42.261
38.694
−42.081
1.00
27.05
B
C


ATOM
15978
CB
LYS
B
479
43.538
39.169
−41.392
1.00
28.04
B
C


ATOM
15981
CG
LYS
B
479
43.434
39.286
−39.858
1.00
32.43
B
C


ATOM
15984
CD
LYS
B
479
42.899
40.662
−39.421
1.00
41.92
B
C


ATOM
15987
CE
LYS
B
479
42.652
40.733
−37.915
1.00
48.99
B
C


ATOM
15990
NZ
LYS
B
479
42.370
42.129
−37.475
1.00
48.92
B
N


ATOM
15994
C
LYS
B
479
42.368
38.915
−43.593
1.00
28.30
B
C


ATOM
15995
O
LYS
B
479
42.444
40.064
−44.042
1.00
30.46
B
O


ATOM
15997
N
GLY
B
480
42.335
37.844
−44.384
1.00
27.75
B
N


ATOM
15998
CA
GLY
B
480
42.483
37.962
−45.838
1.00
27.63
B
C


ATOM
16001
C
GLY
B
480
43.873
38.401
−46.270
1.00
27.82
B
C


ATOM
16002
O
GLY
B
480
44.014
39.224
−47.167
1.00
28.13
B
O


ATOM
16004
N
ILE
B
481
44.910
37.846
−45.638
1.00
27.16
B
N


ATOM
16005
CA
ILE
B
481
46.294
38.221
−45.964
1.00
27.84
B
C


ATOM
16007
CB
ILE
B
481
46.978
39.002
−44.812
1.00
27.50
B
C


ATOM
16009
CG1
ILE
B
481
47.018
38.173
−43.515
1.00
26.34
B
C


ATOM
16012
CD1
ILE
B
481
47.775
38.847
−42.350
1.00
23.73
B
C


ATOM
16016
CG2
ILE
B
481
46.260
40.328
−44.607
1.00
27.59
B
C


ATOM
16020
C
ILE
B
481
47.138
37.024
−46.393
1.00
28.16
B
C


ATOM
16021
O
ILE
B
481
46.725
35.888
−46.255
1.00
30.84
B
O


ATOM
16023
N
SER
B
482
48.305
37.308
−46.954
1.00
30.02
B
N


ATOM
16024
CA
SER
B
482
49.283
36.301
−47.364
1.00
30.53
B
C


ATOM
16026
CB
SER
B
482
50.364
36.989
−48.173
1.00
30.13
B
C


ATOM
16029
OG
SER
B
482
50.971
37.996
−47.377
1.00
28.80
B
O


ATOM
16031
C
SER
B
482
49.968
35.638
−46.164
1.00
31.57
B
C


ATOM
16032
O
SER
B
482
50.006
36.209
−45.074
1.00
31.84
B
O


ATOM
16034
N
GLU
B
483
50.548
34.461
−46.390
1.00
30.45
B
N


ATOM
16035
CA
GLU
B
483
51.308
33.774
−45.371
1.00
31.95
B
C


ATOM
16037
CB
GLU
B
483
51.969
32.521
−45.952
1.00
32.69
B
C


ATOM
16040
CG
GLU
B
483
52.874
31.797
−44.939
1.00
35.01
B
C


ATOM
16043
CD
GLU
B
483
53.216
30.353
−45.314
1.00
41.67
B
C


ATOM
16044
OE1
GLU
B
483
52.776
29.875
−46.389
1.00
39.44
B
O


ATOM
16045
OE2
GLU
B
483
53.939
29.701
−44.511
1.00
39.15
B
O


ATOM
16046
C
GLU
B
483
52.353
34.672
−44.706
1.00
32.33
B
C


ATOM
16047
O
GLU
B
483
52.486
34.704
−43.482
1.00
33.44
B
O


ATOM
16049
N
GLU
B
484
53.073
35.412
−45.522
1.00
33.10
B
N


ATOM
16050
CA
GLU
B
484
54.133
36.271
−45.054
1.00
35.44
B
C


ATOM
16052
CB
GLU
B
484
54.806
36.958
−46.254
1.00
37.40
B
C


ATOM
16055
CG
GLU
B
484
56.049
37.754
−45.888
1.00
47.37
B
C


ATOM
16058
CD
GLU
B
484
56.678
38.484
−47.076
1.00
61.47
B
C


ATOM
16059
OE1
GLU
B
484
56.049
38.576
−48.162
1.00
64.59
B
O


ATOM
16060
OE2
GLU
B
484
57.815
38.975
−46.906
1.00
63.79
B
O


ATOM
16061
C
GLU
B
484
53.636
37.330
−44.064
1.00
33.41
B
C


ATOM
16062
O
GLU
B
484
54.285
37.580
−43.049
1.00
30.95
B
O


ATOM
16064
N
LEU
B
485
52.516
37.974
−44.375
1.00
31.70
B
N


ATOM
16065
CA
LEU
B
485
51.982
39.005
−43.489
1.00
31.52
B
C


ATOM
16067
CB
LEU
B
485
50.969
39.899
−44.218
1.00
33.56
B
C


ATOM
16070
CG
LEU
B
485
51.561
40.942
−45.174
1.00
37.32
B
C


ATOM
16072
CD1
LEU
B
485
50.509
41.463
−46.157
1.00
36.05
B
C


ATOM
16076
CD2
LEU
B
485
52.180
42.087
−44.377
1.00
42.57
B
C


ATOM
16080
C
LEU
B
485
51.360
38.383
−42.229
1.00
28.30
B
C


ATOM
16081
O
LEU
B
485
51.426
38.957
−41.157
1.00
25.25
B
O


ATOM
16083
N
ALA
B
486
50.782
37.201
−42.367
1.00
26.73
B
N


ATOM
16084
CA
ALA
B
486
50.173
36.528
−41.243
1.00
26.36
B
C


ATOM
16086
CB
ALA
B
486
49.358
35.304
−41.718
1.00
23.95
B
C


ATOM
16090
C
ALA
B
486
51.281
36.134
−40.269
1.00
24.95
B
C


ATOM
16091
O
ALA
B
486
51.141
36.267
−39.048
1.00
22.96
B
O


ATOM
16093
N
THR
B
487
52.397
35.706
−40.835
1.00
25.77
B
N


ATOM
16094
CA
THR
B
487
53.581
35.312
−40.069
1.00
27.48
B
C


ATOM
16096
CB
THR
B
487
54.654
34.714
−41.004
1.00
29.14
B
C


ATOM
16098
OG1
THR
B
487
54.120
33.537
−41.647
1.00
29.56
B
O


ATOM
16100
CG2
THR
B
487
55.884
34.343
−40.234
1.00
24.58
B
C


ATOM
16104
C
THR
B
487
54.142
36.492
−39.306
1.00
26.57
B
C


ATOM
16105
O
THR
B
487
54.450
36.400
−38.119
1.00
22.40
B
O


ATOM
16107
N
GLU
B
488
54.225
37.624
−39.977
1.00
28.65
B
N


ATOM
16108
CA
GLU
B
488
54.627
38.869
−39.311
1.00
31.12
B
C


ATOM
16110
CB
GLU
B
488
54.701
40.012
−40.336
1.00
33.28
B
C


ATOM
16113
CG
GLU
B
488
55.304
41.334
−39.844
1.00
43.15
B
C


ATOM
16116
CD
GLU
B
488
55.275
42.458
−40.908
1.00
50.77
B
C


ATOM
16117
OE1
GLU
B
488
54.732
42.270
−42.023
1.00
51.52
B
O


ATOM
16118
OE2
GLU
B
488
55.802
43.548
−40.611
1.00
57.46
B
O


ATOM
16119
C
GLU
B
488
53.669
39.187
−38.131
1.00
28.39
B
C


ATOM
16120
O
GLU
B
488
54.129
39.472
−37.027
1.00
25.62
B
O


ATOM
16122
N
SER
B
489
52.354
39.090
−38.351
1.00
25.99
B
N


ATOM
16123
CA
SER
B
489
51.379
39.404
−37.281
1.00
27.20
B
C


ATOM
16125
CB
SER
B
489
49.923
39.418
−37.770
1.00
24.76
B
C


ATOM
16128
OG
SER
B
489
49.709
40.444
−38.695
1.00
30.59
B
O


ATOM
16130
C
SER
B
489
51.473
38.435
−36.118
1.00
25.26
B
C


ATOM
16131
O
SER
B
489
51.327
38.835
−34.979
1.00
25.76
B
O


ATOM
16133
N
VAL
B
490
51.703
37.165
−36.401
1.00
24.32
B
N


ATOM
16134
CA
VAL
B
490
51.890
36.201
−35.318
1.00
24.64
B
C


ATOM
16136
CB
VAL
B
490
51.905
34.758
−35.847
1.00
24.98
B
C


ATOM
16138
CG1
VAL
B
490
52.313
33.755
−34.747
1.00
24.04
B
C


ATOM
16142
CG2
VAL
B
490
50.555
34.409
−36.395
1.00
20.83
B
C


ATOM
16146
C
VAL
B
490
53.133
36.517
−34.465
1.00
25.21
B
C


ATOM
16147
O
VAL
B
490
53.084
36.405
−33.252
1.00
26.85
B
O


ATOM
16149
N
MET
B
491
54.221
36.962
−35.085
1.00
27.17
B
N


ATOM
16150
CA
MET
B
491
55.441
37.314
−34.345
1.00
27.17
B
C


ATOM
16152
CB
MET
B
491
56.619
37.595
−35.286
1.00
29.59
B
C


ATOM
16155
CG
MET
B
491
56.984
36.475
−36.254
1.00
32.48
B
C


ATOM
16158
SD
MET
B
491
58.082
35.259
−35.532
1.00
54.54
B
S


ATOM
16159
CE
MET
B
491
58.676
34.476
−37.042
1.00
58.30
B
C


ATOM
16163
C
MET
B
491
55.183
38.545
−33.498
1.00
26.01
B
C


ATOM
16164
O
MET
B
491
55.677
38.646
−32.387
1.00
27.29
B
O


ATOM
16166
N
ASN
B
492
54.414
39.494
−34.024
1.00
25.33
B
N


ATOM
16167
CA
ASN
B
492
54.027
40.675
−33.241
1.00
25.11
B
C


ATOM
16169
CB
ASN
B
492
53.294
41.713
−34.100
1.00
26.44
B
C


ATOM
16172
CG
ASN
B
492
54.206
42.393
−35.135
1.00
31.18
B
C


ATOM
16173
OD1
ASN
B
492
55.413
42.496
−34.944
1.00
41.61
B
O


ATOM
16174
ND2
ASN
B
492
53.610
42.884
−36.226
1.00
31.04
B
N


ATOM
16177
C
ASN
B
492
53.163
40.308
−32.025
1.00
21.95
B
C


ATOM
16178
O
ASN
B
492
53.310
40.913
−30.977
1.00
23.50
B
O


ATOM
16180
N
LEU
B
493
52.272
39.332
−32.176
1.00
16.94
B
N


ATOM
16181
CA
LEU
B
493
51.452
38.837
−31.078
1.00
19.50
B
C


ATOM
16183
CB
LEU
B
493
50.401
37.871
−31.626
1.00
20.12
B
C


ATOM
16186
CG
LEU
B
493
49.330
37.252
−30.730
1.00
29.36
B
C


ATOM
16188
CD1
LEU
B
493
48.557
38.309
−29.904
1.00
28.24
B
C


ATOM
16192
CD2
LEU
B
493
48.355
36.399
−31.599
1.00
21.19
B
C


ATOM
16196
C
LEU
B
493
52.359
38.162
−30.021
1.00
19.84
B
C


ATOM
16197
O
LEU
B
493
52.219
38.393
−28.819
1.00
19.40
B
O


ATOM
16199
N
ILE
B
494
53.326
37.380
−30.477
1.00
20.01
B
N


ATOM
16200
CA
ILE
B
494
54.330
36.845
−29.569
1.00
20.75
B
C


ATOM
16202
CB
ILE
B
494
55.346
35.966
−30.315
1.00
20.42
B
C


ATOM
16204
CG1
ILE
B
494
54.646
34.675
−30.739
1.00
16.69
B
C


ATOM
16207
CD1
ILE
B
494
55.474
33.814
−31.610
1.00
19.06
B
C


ATOM
16211
CG2
ILE
B
494
56.521
35.613
−29.418
1.00
20.38
B
C


ATOM
16215
C
ILE
B
494
55.009
37.965
−28.770
1.00
20.30
B
C


ATOM
16216
O
ILE
B
494
55.087
37.890
−27.548
1.00
20.50
B
O


ATOM
16218
N
ASP
B
495
55.429
39.026
−29.442
1.00
20.29
B
N


ATOM
16219
CA
ASP
B
495
56.042
40.169
−28.763
1.00
20.00
B
C


ATOM
16221
CB
ASP
B
495
56.476
41.235
−29.773
1.00
19.65
B
C


ATOM
16224
CG
ASP
B
495
57.672
40.795
−30.609
1.00
22.70
B
C


ATOM
16225
OD1
ASP
B
495
58.358
39.819
−30.243
1.00
32.40
B
O


ATOM
16226
OD2
ASP
B
495
57.943
41.429
−31.644
1.00
33.90
B
O


ATOM
16227
C
ASP
B
495
55.140
40.800
−27.717
1.00
22.04
B
C


ATOM
16228
O
ASP
B
495
55.567
41.053
−26.588
1.00
23.10
B
O


ATOM
16230
N
GLU
B
496
53.897
41.061
−28.088
1.00
23.21
B
N


ATOM
16231
CA
GLU
B
496
52.959
41.715
−27.191
1.00
25.03
B
C


ATOM
16233
CB
GLU
B
496
51.643
42.007
−27.902
1.00
24.60
B
C


ATOM
16236
CG
GLU
B
496
51.772
43.101
−28.938
1.00
34.66
B
C


ATOM
16239
CD
GLU
B
496
52.250
44.433
−28.354
1.00
43.94
B
C


ATOM
16240
OE1
GLU
B
496
53.248
44.980
−28.880
1.00
45.89
B
O


ATOM
16241
OE2
GLU
B
496
51.633
44.926
−27.377
1.00
48.24
B
O


ATOM
16242
C
GLU
B
496
52.693
40.840
−26.003
1.00
23.68
B
C


ATOM
16243
O
GLU
B
496
52.579
41.339
−24.882
1.00
23.34
B
O


ATOM
16245
N
THR
B
497
52.606
39.534
−26.257
1.00
21.60
B
N


ATOM
16246
CA
THR
B
497
52.340
38.571
−25.214
1.00
21.88
B
C


ATOM
16248
CB
THR
B
497
52.112
37.168
−25.799
1.00
22.84
B
C


ATOM
16250
OG1
THR
B
497
51.067
37.231
−26.790
1.00
24.32
B
O


ATOM
16252
CG2
THR
B
497
51.719
36.222
−24.710
1.00
18.88
B
C


ATOM
16256
C
THR
B
497
53.510
38.565
−24.217
1.00
21.49
B
C


ATOM
16257
O
THR
B
497
53.295
38.521
−23.022
1.00
20.84
B
O


ATOM
16259
N
TRP
B
498
54.737
38.654
−24.715
1.00
19.80
B
N


ATOM
16260
CA
TRP
B
498
55.892
38.786
−23.847
1.00
21.21
B
C


ATOM
16262
CB
TRP
B
498
57.194
38.771
−24.641
1.00
20.21
B
C


ATOM
16265
CG
TRP
B
498
57.821
37.406
−24.729
1.00
22.28
B
C


ATOM
16266
CD1
TRP
B
498
57.768
36.547
−25.786
1.00
18.79
B
C


ATOM
16268
NE1
TRP
B
498
58.454
35.404
−25.497
1.00
23.07
B
N


ATOM
16270
CE2
TRP
B
498
58.985
35.508
−24.241
1.00
18.89
B
C


ATOM
16271
CD2
TRP
B
498
58.603
36.756
−23.726
1.00
23.52
B
C


ATOM
16272
CE3
TRP
B
498
59.019
37.107
−22.439
1.00
25.36
B
C


ATOM
16274
CZ3
TRP
B
498
59.775
36.204
−21.715
1.00
24.20
B
C


ATOM
16276
CH2
TRP
B
498
60.147
34.974
−22.259
1.00
20.69
B
C


ATOM
16278
CZ2
TRP
B
498
59.759
34.607
−23.516
1.00
25.94
B
C


ATOM
16280
C
TRP
B
498
55.844
40.048
−22.992
1.00
21.86
B
C


ATOM
16281
O
TRP
B
498
56.199
40.028
−21.809
1.00
22.63
B
O


ATOM
16283
N
LYS
B
499
55.404
41.147
−23.576
1.00
22.03
B
N


ATOM
16284
CA
LYS
B
499
55.328
42.379
−22.823
1.00
22.69
B
C


ATOM
16286
CB
LYS
B
499
54.851
43.541
−23.692
1.00
23.12
B
C


ATOM
16289
CG
LYS
B
499
55.860
43.971
−24.779
1.00
19.45
B
C


ATOM
16292
CD
LYS
B
499
55.348
45.181
−25.597
1.00
20.45
B
C


ATOM
16295
CE
LYS
B
499
56.178
45.364
−26.882
1.00
24.37
B
C


ATOM
16298
NZ
LYS
B
499
55.795
46.603
−27.636
1.00
25.22
B
N


ATOM
16302
C
LYS
B
499
54.438
42.197
−21.603
1.00
23.79
B
C


ATOM
16303
O
LYS
B
499
54.781
42.641
−20.506
1.00
26.86
B
O


ATOM
16305
N
LYS
B
500
53.332
41.492
−21.776
1.00
24.19
B
N


ATOM
16306
CA
LYS
B
500
52.421
41.226
−20.670
1.00
24.67
B
C


ATOM
16308
CB
LYS
B
500
51.083
40.762
−21.234
1.00
27.83
B
C


ATOM
16311
CG
LYS
B
500
50.405
41.905
−21.987
1.00
27.12
B
C


ATOM
16314
CD
LYS
B
500
49.172
41.461
−22.733
1.00
34.50
B
C


ATOM
16317
CE
LYS
B
500
48.524
42.638
−23.450
1.00
34.28
B
C


ATOM
16320
NZ
LYS
B
500
47.799
42.149
−24.632
1.00
42.60
B
N


ATOM
16324
C
LYS
B
500
52.951
40.237
−19.628
1.00
23.00
B
C


ATOM
16325
O
LYS
B
500
52.735
40.416
−18.443
1.00
24.58
B
O


ATOM
16327
N
MET
B
501
53.669
39.208
−20.055
1.00
22.99
B
N


ATOM
16328
CA
MET
B
501
54.321
38.326
−19.099
1.00
20.54
B
C


ATOM
16330
CB
MET
B
501
55.005
37.163
−19.801
1.00
20.14
B
C


ATOM
16333
CG
MET
B
501
54.036
36.223
−20.472
1.00
24.64
B
C


ATOM
16336
SD
MET
B
501
54.785
34.668
−21.007
1.00
29.22
B
S


ATOM
16337
CE
MET
B
501
56.131
35.198
−22.016
1.00
26.22
B
C


ATOM
16341
C
MET
B
501
55.330
39.112
−18.278
1.00
19.87
B
C


ATOM
16342
O
MET
B
501
55.398
38.941
−17.069
1.00
23.88
B
O


ATOM
16344
N
ASN
B
502
56.096
39.979
−18.928
1.00
18.65
B
N


ATOM
16345
CA
ASN
B
502
57.129
40.749
−18.260
1.00
19.97
B
C


ATOM
16347
CB
ASN
B
502
57.837
41.683
−19.265
1.00
18.67
B
C


ATOM
16350
CG
ASN
B
502
58.811
40.958
−20.196
1.00
22.60
B
C


ATOM
16351
OD1
ASN
B
502
59.178
39.788
−19.987
1.00
22.42
B
O


ATOM
16352
ND2
ASN
B
502
59.273
41.685
−21.224
1.00
16.81
B
N


ATOM
16355
C
ASN
B
502
56.523
41.576
−17.119
1.00
22.98
B
C


ATOM
16356
O
ASN
B
502
57.114
41.713
−16.027
1.00
24.16
B
O


ATOM
16358
N
LYS
B
503
55.342
42.136
−17.376
1.00
24.97
B
N


ATOM
16359
CA
LYS
B
503
54.643
42.934
−16.369
1.00
28.54
B
C


ATOM
16361
CB
LYS
B
503
53.493
43.719
−17.003
1.00
27.67
B
C


ATOM
16364
CG
LYS
B
503
52.638
44.472
−16.012
1.00
33.09
B
C


ATOM
16367
CD
LYS
B
503
51.658
45.394
−16.757
1.00
41.49
B
C


ATOM
16370
CE
LYS
B
503
50.925
46.355
−15.801
1.00
47.16
B
C


ATOM
16373
NZ
LYS
B
503
49.615
46.854
−16.376
1.00
45.45
B
N


ATOM
16377
C
LYS
B
503
54.141
42.058
−15.221
1.00
28.95
B
C


ATOM
16378
O
LYS
B
503
54.307
42.396
−14.056
1.00
30.69
B
O


ATOM
16380
N
GLU
B
504
53.522
40.938
−15.546
1.00
30.28
B
N


ATOM
16381
CA
GLU
B
504
53.101
39.983
−14.508
1.00
31.89
B
C


ATOM
16383
CB
GLU
B
504
52.551
38.690
−15.149
1.00
33.44
B
C


ATOM
16386
CG
GLU
B
504
51.701
37.808
−14.225
1.00
38.98
B
C


ATOM
16389
CD
GLU
B
504
50.382
38.465
−13.829
1.00
47.41
B
C


ATOM
16390
OE1
GLU
B
504
49.897
38.183
−12.715
1.00
52.15
B
O


ATOM
16391
OE2
GLU
B
504
49.841
39.277
−14.618
1.00
50.82
B
O


ATOM
16392
C
GLU
B
504
54.267
39.675
−13.555
1.00
29.72
B
C


ATOM
16393
O
GLU
B
504
54.119
39.732
−12.335
1.00
31.31
B
O


ATOM
16395
N
LYS
B
505
55.433
39.388
−14.114
1.00
28.05
B
N


ATOM
16396
CA
LYS
B
505
56.601
38.981
−13.323
1.00
27.17
B
C


ATOM
16398
CB
LYS
B
505
57.735
38.562
−14.266
1.00
25.64
B
C


ATOM
16401
CG
LYS
B
505
59.066
38.259
−13.594
1.00
26.00
B
C


ATOM
16404
CD
LYS
B
505
58.995
37.017
−12.710
1.00
25.01
B
C


ATOM
16407
CE
LYS
B
505
60.305
36.802
−11.941
1.00
22.47
B
C


ATOM
16410
NZ
LYS
B
505
61.449
36.651
−12.865
1.00
30.06
B
N


ATOM
16414
C
LYS
B
505
57.080
40.122
−12.423
1.00
29.79
B
C


ATOM
16415
O
LYS
B
505
57.422
39.943
−11.258
1.00
30.03
B
O


ATOM
16417
N
LEU
B
506
57.092
41.306
−12.993
1.00
33.92
B
N


ATOM
16418
CA
LEU
B
506
57.667
42.466
−12.352
1.00
37.31
B
C


ATOM
16420
CB
LEU
B
506
57.784
43.589
−13.383
1.00
37.37
B
C


ATOM
16423
CG
LEU
B
506
58.791
44.692
−13.143
1.00
42.52
B
C


ATOM
16425
CD1
LEU
B
506
60.133
44.138
−12.685
1.00
39.23
B
C


ATOM
16429
CD2
LEU
B
506
58.933
45.485
−14.443
1.00
47.19
B
C


ATOM
16433
C
LEU
B
506
56.838
42.932
−11.174
1.00
39.52
B
C


ATOM
16434
O
LEU
B
506
57.386
43.311
−10.144
1.00
40.98
B
O


ATOM
16436
N
GLY
B
507
55.521
42.894
−11.319
1.00
42.30
B
N


ATOM
16437
CA
GLY
B
507
54.656
43.514
−10.336
1.00
45.83
B
C


ATOM
16440
C
GLY
B
507
53.330
42.824
−10.120
1.00
49.02
B
C


ATOM
16441
O
GLY
B
507
52.686
42.354
−11.062
1.00
51.49
B
O


ATOM
16443
N
GLY
B
508
52.953
42.755
−8.846
1.00
51.72
B
N


ATOM
16444
CA
GLY
B
508
51.591
42.445
−8.415
1.00
52.78
B
C


ATOM
16447
C
GLY
B
508
50.900
41.218
−8.984
1.00
51.93
B
C


ATOM
16448
O
GLY
B
508
49.723
41.287
−9.375
1.00
54.01
B
O


ATOM
16450
N
SER
B
509
51.595
40.092
−9.038
1.00
49.18
B
N


ATOM
16451
CA
ASER
B
509
50.977
38.831
−9.421
0.50
48.36
B
C


ATOM
16452
CA
BSER
B
509
50.890
38.872
−9.440
0.50
48.06
B
C


ATOM
16455
CB
ASER
B
509
52.060
37.834
−9.871
0.50
48.19
B
C


ATOM
16456
CB
BSER
B
509
51.793
37.829
−10.102
0.50
47.86
B
C


ATOM
16461
OG
ASER
B
509
53.237
37.924
−9.070
0.50
46.36
B
O


ATOM
16462
OG
BSER
B
509
50.997
36.778
−10.655
0.50
43.78
B
O


ATOM
16465
C
SER
B
509
50.184
38.268
−8.237
1.00
47.03
B
C


ATOM
16466
O
SER
B
509
50.561
38.492
−7.083
1.00
45.61
B
O


ATOM
16468
N
LEU
B
510
49.118
37.529
−8.528
1.00
46.26
B
N


ATOM
16469
CA
LEU
B
510
48.442
36.736
−7.513
1.00
45.94
B
C


ATOM
16471
CB
LEU
B
510
47.146
36.129
−8.067
1.00
47.18
B
C


ATOM
16474
CG
LEU
B
510
46.198
37.118
−8.781
1.00
53.98
B
C


ATOM
16476
CD1
LEU
B
510
44.910
36.427
−9.230
1.00
58.51
B
C


ATOM
16480
CD2
LEU
B
510
45.873
38.358
−7.911
1.00
59.66
B
C


ATOM
16484
C
LEU
B
510
49.432
35.643
−7.040
1.00
43.67
B
C


ATOM
16485
O
LEU
B
510
49.486
35.316
−5.843
1.00
45.41
B
O


ATOM
16487
N
PHE
B
511
50.262
35.156
−7.969
1.00
37.67
B
N


ATOM
16488
CA
PHE
B
511
51.233
34.089
−7.707
1.00
35.65
B
C


ATOM
16490
CB
PHE
B
511
51.418
33.218
−8.967
1.00
34.37
B
C


ATOM
16493
CG
PHE
B
511
50.169
32.496
−9.394
1.00
29.50
B
C


ATOM
16494
CD1
PHE
B
511
49.935
31.208
−8.981
1.00
27.92
B
C


ATOM
16496
CE1
PHE
B
511
48.772
30.537
−9.360
1.00
32.35
B
C


ATOM
16498
CZ
PHE
B
511
47.838
31.173
−10.146
1.00
33.79
B
C


ATOM
16500
CE2
PHE
B
511
48.062
32.483
−10.557
1.00
31.04
B
C


ATOM
16502
CD2
PHE
B
511
49.213
33.128
−10.180
1.00
27.15
B
C


ATOM
16504
C
PHE
B
511
52.596
34.603
−7.235
1.00
35.79
B
C


ATOM
16505
O
PHE
B
511
52.977
35.747
−7.481
1.00
36.71
B
O


ATOM
16507
N
ALA
B
512
53.343
33.747
−6.555
1.00
36.55
B
N


ATOM
16508
CA
ALA
B
512
54.681
34.127
−6.137
1.00
37.34
B
C


ATOM
16510
CB
ALA
B
512
55.203
33.149
−5.078
1.00
36.86
B
C


ATOM
16514
C
ALA
B
512
55.593
34.159
−7.380
1.00
37.03
B
C


ATOM
16515
O
ALA
B
512
55.400
33.384
−8.315
1.00
35.37
B
O


ATOM
16517
N
LYS
B
513
56.575
35.061
−7.381
1.00
37.04
B
N


ATOM
16518
CA
LYS
B
513
57.500
35.233
−8.519
1.00
36.97
B
C


ATOM
16520
CB
LYS
B
513
58.511
36.341
−8.230
1.00
36.08
B
C


ATOM
16523
CG
LYS
B
513
57.877
37.716
−8.124
1.00
43.23
B
C


ATOM
16526
CD
LYS
B
513
58.928
38.808
−7.942
1.00
51.27
B
C


ATOM
16529
CE
LYS
B
513
58.301
40.198
−7.948
1.00
56.81
B
C


ATOM
16532
NZ
LYS
B
513
59.264
41.260
−8.368
1.00
56.22
B
N


ATOM
16536
C
LYS
B
513
58.236
33.964
−9.006
1.00
34.73
B
C


ATOM
16537
O
LYS
B
513
58.529
33.847
−10.184
1.00
35.14
B
O


ATOM
16539
N
PRO
B
514
58.539
33.019
−8.111
1.00
33.75
B
N


ATOM
16540
CA
PRO
B
514
59.171
31.801
−8.618
1.00
31.10
B
C


ATOM
16542
CB
PRO
B
514
59.475
30.993
−7.350
1.00
31.76
B
C


ATOM
16545
CG
PRO
B
514
59.565
32.013
−6.258
1.00
33.72
B
C


ATOM
16548
CD
PRO
B
514
58.575
33.088
−6.636
1.00
34.82
B
C


ATOM
16551
C
PRO
B
514
58.274
30.994
−9.531
1.00
29.47
B
C


ATOM
16552
O
PRO
B
514
58.761
30.432
−10.505
1.00
31.73
B
O


ATOM
16553
N
PHE
B
515
56.980
30.921
−9.229
1.00
27.01
B
N


ATOM
16554
CA
PHE
B
515
56.080
30.186
−10.095
1.00
24.99
B
C


ATOM
16556
CB
PHE
B
515
54.791
29.771
−9.412
1.00
22.89
B
C


ATOM
16559
CG
PHE
B
515
53.802
29.171
−10.366
1.00
25.51
B
C


ATOM
16560
CD1
PHE
B
515
54.021
27.920
−10.902
1.00
26.17
B
C


ATOM
16562
CE1
PHE
B
515
53.126
27.366
−11.810
1.00
26.76
B
C


ATOM
16564
CZ
PHE
B
515
52.039
28.081
−12.196
1.00
22.84
B
C


ATOM
16566
CE2
PHE
B
515
51.816
29.356
−11.661
1.00
20.66
B
C


ATOM
16568
CD2
PHE
B
515
52.695
29.884
−10.779
1.00
22.38
B
C


ATOM
16570
C
PHE
B
515
55.789
31.000
−11.364
1.00
24.60
B
C


ATOM
16571
O
PHE
B
515
55.775
30.452
−12.455
1.00
25.39
B
O


ATOM
16573
N
VAL
B
516
55.598
32.301
−11.241
1.00
23.02
B
N


ATOM
16574
CA
VAL
B
516
55.459
33.127
−12.435
1.00
22.33
B
C


ATOM
16576
CB
VAL
B
516
55.339
34.620
−12.126
1.00
23.22
B
C


ATOM
16578
CG1
VAL
B
516
54.200
34.904
−11.108
1.00
23.93
B
C


ATOM
16582
CG2
VAL
B
516
55.087
35.401
−13.412
1.00
19.34
B
C


ATOM
16586
C
VAL
B
516
56.633
32.914
−13.403
1.00
22.95
B
C


ATOM
16587
O
VAL
B
516
56.435
32.854
−14.629
1.00
23.90
B
O


ATOM
16589
N
GLU
B
517
57.834
32.776
−12.854
1.00
21.79
B
N


ATOM
16590
CA
GLU
B
517
59.049
32.572
−13.651
1.00
22.46
B
C


ATOM
16592
CB
GLU
B
517
60.298
32.804
−12.771
1.00
24.28
B
C


ATOM
16595
CG
GLU
B
517
61.663
32.717
−13.489
1.00
22.17
B
C


ATOM
16598
CD
GLU
B
517
61.902
33.823
−14.511
1.00
26.69
B
C


ATOM
16599
OE1
GLU
B
517
61.121
34.806
−14.594
1.00
26.06
B
O


ATOM
16600
OE2
GLU
B
517
62.892
33.702
−15.252
1.00
29.10
B
O


ATOM
16601
C
GLU
B
517
59.098
31.172
−14.273
1.00
21.73
B
C


ATOM
16602
O
GLU
B
517
59.505
31.018
−15.415
1.00
24.57
B
O


ATOM
16604
N
THR
B
518
58.717
30.151
−13.512
1.00
23.11
B
N


ATOM
16605
CA
THR
B
518
58.574
28.798
−14.050
1.00
22.81
B
C


ATOM
16607
CB
THR
B
518
58.094
27.811
−12.963
1.00
24.80
B
C


ATOM
16609
OG1
THR
B
518
59.091
27.713
−11.936
1.00
21.57
B
O


ATOM
16611
CG2
THR
B
518
57.851
26.398
−13.562
1.00
21.21
B
C


ATOM
16615
C
THR
B
518
57.599
28.819
−15.245
1.00
23.51
B
C


ATOM
16616
O
THR
B
518
57.850
28.237
−16.297
1.00
22.08
B
O


ATOM
16618
N
ALA
B
519
56.515
29.554
−15.105
1.00
21.37
B
N


ATOM
16619
CA
ALA
B
519
55.553
29.635
−16.188
1.00
21.72
B
C


ATOM
16621
CB
ALA
B
519
54.308
30.395
−15.737
1.00
20.07
B
C


ATOM
16625
C
ALA
B
519
56.190
30.272
−17.429
1.00
20.28
B
C


ATOM
16626
O
ALA
B
519
56.043
29.775
−18.555
1.00
19.22
B
O


ATOM
16628
N
ILE
B
520
56.935
31.350
−17.227
1.00
19.49
B
N


ATOM
16629
CA
ILE
B
520
57.552
32.014
−18.366
1.00
18.67
B
C


ATOM
16631
CB
ILE
B
520
58.218
33.311
−17.947
1.00
19.91
B
C


ATOM
16633
CG1
ILE
B
520
57.161
34.343
−17.572
1.00
21.75
B
C


ATOM
16636
CD1
ILE
B
520
57.701
35.559
−16.769
1.00
20.13
B
C


ATOM
16640
CG2
ILE
B
520
59.083
33.848
−19.091
1.00
18.40
B
C


ATOM
16644
C
ILE
B
520
58.573
31.106
−19.044
1.00
18.88
B
C


ATOM
16645
O
ILE
B
520
58.740
31.162
−20.255
1.00
20.10
B
O


ATOM
16647
N
ASN
B
521
59.256
30.264
−18.268
1.00
18.94
B
N


ATOM
16648
CA
ASN
B
521
60.166
29.282
−18.848
1.00
21.21
B
C


ATOM
16650
CB
ASN
B
521
60.849
28.442
−17.757
1.00
23.50
B
C


ATOM
16653
CG
ASN
B
521
61.829
29.269
−16.895
1.00
26.39
B
C


ATOM
16654
OD1
ASN
B
521
62.321
30.339
−17.308
1.00
20.77
B
O


ATOM
16655
ND2
ASN
B
521
62.126
28.755
−15.700
1.00
21.46
B
N


ATOM
16658
C
ASN
B
521
59.486
28.367
−19.862
1.00
19.68
B
C


ATOM
16659
O
ASN
B
521
60.113
27.923
−20.824
1.00
22.84
B
O


ATOM
16661
N
LEU
B
522
58.208
28.091
−19.692
1.00
20.02
B
N


ATOM
16662
CA
LEU
B
522
57.544
27.288
−20.700
1.00
22.98
B
C


ATOM
16664
CB
LEU
B
522
56.093
27.008
−20.356
1.00
23.26
B
C


ATOM
16667
CG
LEU
B
522
55.375
26.269
−21.493
1.00
25.82
B
C


ATOM
16669
CD1
LEU
B
522
55.246
24.827
−21.145
1.00
31.80
B
C


ATOM
16673
CD2
LEU
B
522
54.016
26.847
−21.730
1.00
25.39
B
C


ATOM
16677
C
LEU
B
522
57.625
28.024
−22.040
1.00
22.13
B
C


ATOM
16678
O
LEU
B
522
57.880
27.402
−23.081
1.00
25.60
B
O


ATOM
16680
N
ALA
B
523
57.441
29.336
−22.015
1.00
17.13
B
N


ATOM
16681
CA
ALA
B
523
57.550
30.111
−23.240
1.00
19.20
B
C


ATOM
16683
CB
ALA
B
523
57.176
31.574
−23.011
1.00
18.47
B
C


ATOM
16687
C
ALA
B
523
58.936
30.029
−23.786
1.00
18.17
B
C


ATOM
16688
O
ALA
B
523
59.102
29.951
−24.972
1.00
18.29
B
O


ATOM
16690
N
ARG
B
524
59.937
30.084
−22.904
1.00
20.77
B
N


ATOM
16691
CA
ARG
B
524
61.325
30.052
−23.343
1.00
20.63
B
C


ATOM
16693
CB
ARG
B
524
62.285
30.303
−22.162
1.00
22.45
B
C


ATOM
16696
CG
ARG
B
524
62.178
31.723
−21.612
1.00
20.20
B
C


ATOM
16699
CD
ARG
B
524
63.201
32.015
−20.574
1.00
17.77
B
C


ATOM
16702
NE
ARG
B
524
63.198
33.425
−20.165
1.00
17.96
B
N


ATOM
16704
CZ
ARG
B
524
62.938
33.867
−18.944
1.00
20.16
B
C


ATOM
16705
NH1
ARG
B
524
62.638
33.025
−17.961
1.00
24.53
B
N


ATOM
16708
NH2
ARG
B
524
63.015
35.165
−18.692
1.00
19.14
B
N


ATOM
16711
C
ARG
B
524
61.643
28.717
−23.998
1.00
19.90
B
C


ATOM
16712
O
ARG
B
524
62.287
28.679
−25.017
1.00
19.59
B
O


ATOM
16714
N
GLN
B
525
61.179
27.632
−23.398
1.00
21.47
B
N


ATOM
16715
CA
GLN
B
525
61.387
26.314
−23.961
1.00
22.83
B
C


ATOM
16717
CB
GLN
B
525
60.887
25.221
−23.002
1.00
21.14
B
C


ATOM
16720
CG
GLN
B
525
61.193
23.820
−23.486
1.00
26.80
B
C


ATOM
16723
CD
GLN
B
525
62.683
23.560
−23.672
1.00
31.34
B
C


ATOM
16724
OE1
GLN
B
525
63.453
23.736
−22.757
1.00
30.44
B
O


ATOM
16725
NE2
GLN
B
525
63.075
23.120
−24.851
1.00
33.52
B
N


ATOM
16728
C
GLN
B
525
60.721
26.191
−25.332
1.00
23.13
B
C


ATOM
16729
O
GLN
B
525
61.251
25.517
−26.226
1.00
24.85
B
O


ATOM
16731
N
SER
B
526
59.586
26.856
−25.507
1.00
21.76
B
N


ATOM
16732
CA
SER
B
526
58.916
26.851
−26.788
1.00
20.34
B
C


ATOM
16734
CB
SER
B
526
57.571
27.570
−26.692
1.00
21.50
B
C


ATOM
16737
OG
SER
B
526
56.684
26.836
−25.851
1.00
24.20
B
O


ATOM
16739
C
SER
B
526
59.779
27.479
−27.833
1.00
21.36
B
C


ATOM
16740
O
SER
B
526
59.917
26.945
−28.944
1.00
20.48
B
O


ATOM
16742
N
HIS
B
527
60.376
28.622
−27.513
1.00
24.54
B
N


ATOM
16743
CA
HIS
B
527
61.245
29.288
−28.500
1.00
26.44
B
C


ATOM
16745
CB
HIS
B
527
61.754
30.633
−27.984
1.00
28.07
B
C


ATOM
16748
CG
HIS
B
527
60.721
31.719
−27.999
1.00
25.63
B
C


ATOM
16749
ND1
HIS
B
527
60.369
32.390
−29.144
1.00
25.98
B
N


ATOM
16751
CE1
HIS
B
527
59.433
33.278
−28.867
1.00
25.15
B
C


ATOM
16753
NE2
HIS
B
527
59.162
33.209
−27.579
1.00
25.73
B
N


ATOM
16755
CD2
HIS
B
527
59.961
32.245
−27.009
1.00
29.05
B
C


ATOM
16757
C
HIS
B
527
62.431
28.401
−28.858
1.00
28.50
B
C


ATOM
16758
O
HIS
B
527
62.881
28.401
−29.992
1.00
29.68
B
O


ATOM
16760
N
CYS
B
528
62.930
27.631
−27.893
1.00
28.29
B
N


ATOM
16761
CA
CYS
B
528
64.161
26.887
−28.104
1.00
32.46
B
C


ATOM
16763
CB
CYS
B
528
64.855
26.629
−26.769
1.00
32.27
B
C


ATOM
16766
SG
CYS
B
528
65.481
28.140
−26.015
1.00
29.31
B
S


ATOM
16768
C
CYS
B
528
63.912
25.578
−28.852
1.00
34.73
B
C


ATOM
16769
O
CYS
B
528
64.732
25.149
−29.651
1.00
34.26
B
O


ATOM
16771
N
THR
B
529
62.760
24.979
−28.597
1.00
37.83
B
N


ATOM
16772
CA
THR
B
529
62.332
23.742
−29.230
1.00
39.52
B
C


ATOM
16774
CB
THR
B
529
61.225
23.101
−28.376
1.00
39.20
B
C


ATOM
16776
OG1
THR
B
529
61.806
22.677
−27.142
1.00
39.54
B
O


ATOM
16778
CG2
THR
B
529
60.595
21.913
−29.067
1.00
38.45
B
C


ATOM
16782
C
THR
B
529
61.853
23.955
−30.672
1.00
41.75
B
C


ATOM
16783
O
THR
B
529
62.213
23.186
−31.559
1.00
41.23
B
O


ATOM
16785
N
TYR
B
530
61.062
25.001
−30.908
1.00
44.34
B
N


ATOM
16786
CA
TYR
B
530
60.511
25.268
−32.252
1.00
46.43
B
C


ATOM
16788
CB
TYR
B
530
59.041
25.705
−32.158
1.00
44.01
B
C


ATOM
16791
CG
TYR
B
530
58.222
24.607
−31.519
1.00
40.79
B
C


ATOM
16792
CD1
TYR
B
530
57.972
23.409
−32.208
1.00
40.31
B
C


ATOM
16794
CE1
TYR
B
530
57.243
22.359
−31.620
1.00
35.61
B
C


ATOM
16796
CZ
TYR
B
530
56.793
22.481
−30.317
1.00
34.00
B
C


ATOM
16797
OH
TYR
B
530
56.080
21.443
−29.749
1.00
38.96
B
O


ATOM
16799
CE2
TYR
B
530
57.043
23.661
−29.596
1.00
36.22
B
C


ATOM
16801
CD2
TYR
B
530
57.760
24.716
−30.202
1.00
32.71
B
C


ATOM
16803
C
TYR
B
530
61.389
26.233
−33.046
1.00
51.24
B
C


ATOM
16804
O
TYR
B
530
61.027
27.367
−33.322
1.00
52.48
B
O


ATOM
16806
N
HIS
B
531
62.574
25.735
−33.384
1.00
57.86
B
N


ATOM
16807
CA
HIS
B
531
63.502
26.374
−34.322
1.00
61.42
B
C


ATOM
16809
CB
HIS
B
531
64.946
26.178
−33.832
1.00
61.98
B
C


ATOM
16812
CG
HIS
B
531
65.332
24.737
−33.645
1.00
64.97
B
C


ATOM
16813
ND1
HIS
B
531
65.394
24.135
−32.404
1.00
69.47
B
N


ATOM
16815
CE1
HIS
B
531
65.742
22.868
−32.545
1.00
66.30
B
C


ATOM
16817
NE2
HIS
B
531
65.906
22.625
−33.833
1.00
67.05
B
N


ATOM
16819
CD2
HIS
B
531
65.650
23.774
−34.544
1.00
64.50
B
C


ATOM
16821
C
HIS
B
531
63.342
25.741
−35.718
1.00
63.69
B
C


ATOM
16822
O
HIS
B
531
62.596
24.762
−35.878
1.00
61.87
B
O


ATOM
16824
N
ASN
B
532
64.041
26.314
−36.709
1.00
66.30
B
N


ATOM
16825
CA
ASN
B
532
64.175
25.735
−38.056
1.00
68.40
B
C


ATOM
16827
CB
ASN
B
532
63.285
26.481
−39.070
1.00
69.94
B
C


ATOM
16830
CG
ASN
B
532
61.830
25.955
−39.112
1.00
74.76
B
C


ATOM
16831
OD1
ASN
B
532
61.471
25.002
−38.420
1.00
78.95
B
O


ATOM
16832
ND2
ASN
B
532
60.999
26.584
−39.941
1.00
74.30
B
N


ATOM
16835
C
ASN
B
532
65.637
25.768
−38.523
1.00
67.88
B
C


ATOM
16836
O
ASN
B
532
66.527
25.213
−37.869
1.00
66.63
B
O


ATOM
16838
N
THR
B
537
73.132
23.732
−39.964
1.00
92.67
B
N


ATOM
16839
CA
THR
B
537
72.461
22.617
−39.298
1.00
92.98
B
C


ATOM
16841
CB
THR
B
537
72.529
22.759
−37.760
1.00
93.23
B
C


ATOM
16843
OG1
THR
B
537
73.841
23.182
−37.370
1.00
94.15
B
O


ATOM
16845
CG2
THR
B
537
72.203
21.436
−37.073
1.00
93.23
B
C


ATOM
16849
C
THR
B
537
70.993
22.511
−39.725
1.00
92.54
B
C


ATOM
16850
O
THR
B
537
70.356
23.517
−40.039
1.00
92.39
B
O


ATOM
16852
N
SER
B
538
70.470
21.286
−39.728
1.00
92.35
B
N


ATOM
16853
CA
SER
B
538
69.082
21.011
−40.126
1.00
92.17
B
C


ATOM
16855
CB
SER
B
538
68.996
19.620
−40.773
1.00
92.20
B
C


ATOM
16858
OG
SER
B
538
69.869
18.702
−40.139
1.00
90.38
B
O


ATOM
16860
C
SER
B
538
68.120
21.123
−38.928
1.00
91.96
B
C


ATOM
16861
O
SER
B
538
68.571
21.300
−37.795
1.00
91.29
B
O


ATOM
16863
N
PRO
B
539
66.793
21.049
−39.177
1.00
92.14
B
N


ATOM
16864
CA
PRO
B
539
65.805
21.088
−38.083
1.00
91.67
B
C


ATOM
16866
CB
PRO
B
539
64.457
20.853
−38.796
1.00
92.19
B
C


ATOM
16869
CG
PRO
B
539
64.760
20.744
−40.270
1.00
93.38
B
C


ATOM
16872
CD
PRO
B
539
66.147
21.257
−40.486
1.00
92.84
B
C


ATOM
16875
C
PRO
B
539
66.045
20.051
−36.975
1.00
90.54
B
C


ATOM
16876
O
PRO
B
539
66.309
20.431
−35.832
1.00
90.62
B
O


ATOM
16877
N
ASP
B
540
65.954
18.763
−37.298
1.00
88.88
B
N


ATOM
16878
CA
ASP
B
540
66.455
17.730
−36.392
1.00
87.42
B
C


ATOM
16880
CB
ASP
B
540
66.043
16.330
−36.860
1.00
88.42
B
C


ATOM
16883
CG
ASP
B
540
64.596
15.999
−36.524
1.00
91.80
B
C


ATOM
16884
OD1
ASP
B
540
64.173
16.250
−35.369
1.00
91.87
B
O


ATOM
16885
OD2
ASP
B
540
63.893
15.468
−37.417
1.00
93.61
B
O


ATOM
16886
C
ASP
B
540
67.972
17.858
−36.375
1.00
84.38
B
C


ATOM
16887
O
ASP
B
540
68.541
18.552
−37.212
1.00
84.49
B
O


ATOM
16889
N
GLU
B
541
68.626
17.214
−35.416
1.00
80.82
B
N


ATOM
16890
CA
GLU
B
541
70.100
17.233
−35.315
1.00
78.19
B
C


ATOM
16892
CB
GLU
B
541
70.777
16.841
−36.642
1.00
79.32
B
C


ATOM
16895
CG
GLU
B
541
70.278
15.495
−37.189
1.00
82.73
B
C


ATOM
16898
CD
GLU
B
541
71.283
14.798
−38.084
1.00
87.94
B
C


ATOM
16899
OE1
GLU
B
541
72.444
14.620
−37.648
1.00
90.11
B
O


ATOM
16900
OE2
GLU
B
541
70.904
14.416
−39.216
1.00
88.49
B
O


ATOM
16901
C
GLU
B
541
70.682
18.540
−34.751
1.00
73.56
B
C


ATOM
16902
O
GLU
B
541
71.815
18.556
−34.273
1.00
73.40
B
O


ATOM
16904
N
LEU
B
542
69.927
19.632
−34.816
1.00
68.80
B
N


ATOM
16905
CA
LEU
B
542
70.113
20.705
−33.848
1.00
64.68
B
C


ATOM
16907
CB
LEU
B
542
69.553
22.044
−34.340
1.00
64.53
B
C


ATOM
16910
CG
LEU
B
542
69.909
23.238
−33.441
1.00
64.65
B
C


ATOM
16912
CD1
LEU
B
542
69.389
24.543
−34.021
1.00
63.68
B
C


ATOM
16916
CD2
LEU
B
542
71.420
23.328
−33.196
1.00
66.71
B
C


ATOM
16920
C
LEU
B
542
69.415
20.250
−32.563
1.00
60.16
B
C


ATOM
16921
O
LEU
B
542
69.954
20.410
−31.474
1.00
56.80
B
O


ATOM
16923
N
THR
B
543
68.239
19.641
−32.702
1.00
56.33
B
N


ATOM
16924
CA
THR
B
543
67.526
19.101
−31.546
1.00
54.58
B
C


ATOM
16926
CB
THR
B
543
66.124
18.577
−31.927
1.00
52.91
B
C


ATOM
16928
OG1
THR
B
543
65.436
19.560
−32.707
1.00
55.01
B
O


ATOM
16930
CG2
THR
B
543
65.311
18.285
−30.686
1.00
50.48
B
C


ATOM
16934
C
THR
B
543
68.322
17.979
−30.862
1.00
54.20
B
C


ATOM
16935
O
THR
B
543
68.443
17.967
−29.631
1.00
53.54
B
O


ATOM
16937
N
ARG
B
544
68.859
17.042
−31.650
1.00
53.07
B
N


ATOM
16938
CA
ARG
B
544
69.633
15.927
−31.084
1.00
52.95
B
C


ATOM
16940
CB
ARG
B
544
69.966
14.867
−32.153
1.00
53.76
B
C


ATOM
16943
CG
ARG
B
544
71.147
13.934
−31.807
1.00
59.59
B
C


ATOM
16946
CD
ARG
B
544
71.594
13.065
−32.998
1.00
69.45
B
C


ATOM
16949
NE
ARG
B
544
72.185
13.844
−34.099
1.00
74.98
B
N


ATOM
16951
CZ
ARG
B
544
73.462
14.230
−34.184
1.00
78.91
B
C


ATOM
16952
NH1
ARG
B
544
74.342
13.930
−33.226
1.00
79.02
B
N


ATOM
16955
NH2
ARG
B
544
73.866
14.932
−35.244
1.00
79.30
B
N


ATOM
16958
C
ARG
B
544
70.914
16.423
−30.396
1.00
50.09
B
C


ATOM
16959
O
ARG
B
544
71.349
15.822
−29.418
1.00
49.18
B
O


ATOM
16961
N
LYS
B
545
71.512
17.495
−30.920
1.00
47.95
B
N


ATOM
16962
CA
LYS
B
545
72.733
18.060
−30.332
1.00
49.20
B
C


ATOM
16964
CB
LYS
B
545
73.452
19.034
−31.290
1.00
50.06
B
C


ATOM
16967
CG
LYS
B
545
74.568
18.354
−32.088
1.00
58.27
B
C


ATOM
16970
CD
LYS
B
545
75.488
19.319
−32.834
1.00
65.12
B
C


ATOM
16973
CE
LYS
B
545
76.657
18.535
−33.467
1.00
70.31
B
C


ATOM
16976
NZ
LYS
B
545
77.822
19.378
−33.889
1.00
72.09
B
N


ATOM
16980
C
LYS
B
545
72.446
18.743
−29.008
1.00
46.91
B
C


ATOM
16981
O
LYS
B
545
73.292
18.769
−28.115
1.00
48.01
B
O


ATOM
16983
N
ARG
B
546
71.248
19.288
−28.873
1.00
44.64
B
N


ATOM
16984
CA
ARG
B
546
70.871
19.937
−27.632
1.00
43.28
B
C


ATOM
16986
CB
ARG
B
546
69.730
20.917
−27.871
1.00
43.53
B
C


ATOM
16989
CG
ARG
B
546
70.222
22.144
−28.634
1.00
38.72
B
C


ATOM
16992
CD
ARG
B
546
69.107
23.107
−28.977
1.00
38.25
B
C


ATOM
16995
NE
ARG
B
546
69.662
24.350
−29.501
1.00
33.40
B
N


ATOM
16997
CZ
ARG
B
546
68.947
25.364
−29.967
1.00
37.10
B
C


ATOM
16998
NH1
ARG
B
546
67.619
25.316
−29.984
1.00
37.22
B
N


ATOM
17001
NH2
ARG
B
546
69.578
26.440
−30.425
1.00
44.86
B
N


ATOM
17004
C
ARG
B
546
70.554
18.916
−26.552
1.00
42.26
B
C


ATOM
17005
O
ARG
B
546
70.990
19.067
−25.419
1.00
42.38
B
O


ATOM
17007
N
VAL
B
547
69.847
17.851
−26.909
1.00
41.23
B
N


ATOM
17008
CA
VAL
B
547
69.610
16.766
−25.965
1.00
40.03
B
C


ATOM
17010
CB
VAL
B
547
68.784
15.617
−26.584
1.00
41.02
B
C


ATOM
17012
CG1
VAL
B
547
68.755
14.403
−25.652
1.00
42.61
B
C


ATOM
17016
CG2
VAL
B
547
67.388
16.087
−26.894
1.00
35.48
B
C


ATOM
17020
C
VAL
B
547
70.949
16.242
−25.511
1.00
40.46
B
C


ATOM
17021
O
VAL
B
547
71.157
16.006
−24.324
1.00
42.73
B
O


ATOM
17023
N
LEU
B
548
71.869
16.070
−26.454
1.00
39.76
B
N


ATOM
17024
CA
LEU
B
548
73.210
15.609
−26.116
1.00
39.29
B
C


ATOM
17026
CB
LEU
B
548
74.089
15.436
−27.368
1.00
39.65
B
C


ATOM
17029
CG
LEU
B
548
74.394
13.996
−27.805
1.00
45.33
B
C


ATOM
17031
CD1
LEU
B
548
73.140
13.267
−28.315
1.00
42.95
B
C


ATOM
17035
CD2
LEU
B
548
75.493
13.998
−28.880
1.00
46.14
B
C


ATOM
17039
C
LEU
B
548
73.895
16.545
−25.107
1.00
37.32
B
C


ATOM
17040
O
LEU
B
548
74.409
16.086
−24.085
1.00
39.63
B
O


ATOM
17042
N
SER
B
549
73.895
17.844
−25.389
1.00
33.98
B
N


ATOM
17043
CA
SER
B
549
74.656
18.804
−24.587
1.00
32.24
B
C


ATOM
17045
CB
SER
B
549
74.859
20.074
−25.377
1.00
32.05
B
C


ATOM
17048
OG
SER
B
549
73.605
20.666
−25.577
1.00
34.09
B
O


ATOM
17050
C
SER
B
549
73.979
19.171
−23.280
1.00
30.34
B
C


ATOM
17051
O
SER
B
549
74.643
19.569
−22.328
1.00
32.04
B
O


ATOM
17053
N
VAL
B
550
72.658
19.064
−23.232
1.00
28.62
B
N


ATOM
17054
CA
VAL
B
550
71.932
19.383
−22.014
1.00
26.79
B
C


ATOM
17056
CB
VAL
B
550
70.551
19.991
−22.299
1.00
26.82
B
C


ATOM
17058
CG1
VAL
B
550
69.800
20.186
−21.022
1.00
22.61
B
C


ATOM
17062
CG2
VAL
B
550
70.688
21.353
−23.017
1.00
18.25
B
C


ATOM
17066
C
VAL
B
550
71.828
18.162
−21.097
1.00
29.02
B
C


ATOM
17067
O
VAL
B
550
72.112
18.264
−19.906
1.00
28.22
B
O


ATOM
17069
N
ILE
B
551
71.481
16.999
−21.652
1.00
30.73
B
N


ATOM
17070
CA
ILE
B
551
71.234
15.812
−20.832
1.00
31.06
B
C


ATOM
17072
CB
ILE
B
551
70.034
14.999
−21.334
1.00
31.51
B
C


ATOM
17074
CG1
ILE
B
551
68.763
15.849
−21.376
1.00
30.36
B
C


ATOM
17077
CD1
ILE
B
551
68.327
16.382
−20.035
1.00
37.56
B
C


ATOM
17081
CG2
ILE
B
551
69.854
13.747
−20.460
1.00
29.79
B
C


ATOM
17085
C
ILE
B
551
72.395
14.829
−20.762
1.00
32.00
B
C


ATOM
17086
O
ILE
B
551
72.795
14.419
−19.678
1.00
31.17
B
O


ATOM
17088
N
THR
B
552
72.903
14.418
−21.917
1.00
34.78
B
N


ATOM
17089
CA
THR
B
552
73.696
13.200
−21.985
1.00
35.86
B
C


ATOM
17091
CB
THR
B
552
73.372
12.395
−23.266
1.00
38.74
B
C


ATOM
17093
OG1
THR
B
552
73.836
13.097
−24.419
1.00
47.68
B
O


ATOM
17095
CG2
THR
B
552
71.879
12.179
−23.414
1.00
30.46
B
C


ATOM
17099
C
THR
B
552
75.204
13.447
−21.829
1.00
36.32
B
C


ATOM
17100
O
THR
B
552
75.870
12.723
−21.082
1.00
37.04
B
O


ATOM
17102
N
GLU
B
553
75.753
14.469
−22.483
1.00
36.21
B
N


ATOM
17103
CA
GLU
B
553
77.217
14.663
−22.459
1.00
37.69
B
C


ATOM
17105
CB
GLU
B
553
77.744
14.854
−23.887
1.00
40.39
B
C


ATOM
17108
CG
GLU
B
553
77.790
13.550
−24.700
1.00
47.06
B
C


ATOM
17111
CD
GLU
B
553
78.488
13.705
−26.052
1.00
57.90
B
C


ATOM
17112
OE1
GLU
B
553
79.380
12.877
−26.353
1.00
60.24
B
O


ATOM
17113
OE2
GLU
B
553
78.145
14.649
−26.810
1.00
60.91
B
O


ATOM
17114
C
GLU
B
553
77.701
15.811
−21.563
1.00
35.39
B
C


ATOM
17115
O
GLU
B
553
77.311
16.947
−21.751
1.00
34.26
B
O


ATOM
17117
N
PRO
B
554
78.574
15.515
−20.589
1.00
36.02
B
N


ATOM
17118
CA
PRO
B
554
79.201
16.596
−19.827
1.00
34.71
B
C


ATOM
17120
CB
PRO
B
554
80.207
15.875
−18.918
1.00
34.87
B
C


ATOM
17123
CG
PRO
B
554
79.840
14.450
−18.926
1.00
37.61
B
C


ATOM
17126
CD
PRO
B
554
79.055
14.183
−20.176
1.00
37.77
B
C


ATOM
17129
C
PRO
B
554
79.954
17.593
−20.699
1.00
33.50
B
C


ATOM
17130
O
PRO
B
554
80.283
17.322
−21.858
1.00
34.84
B
O


ATOM
17131
N
ILE
B
555
80.209
18.757
−20.132
1.00
32.88
B
N


ATOM
17132
CA
ILE
B
555
81.096
19.725
−20.750
1.00
33.21
B
C


ATOM
17134
CB
ILE
B
555
80.876
21.140
−20.138
1.00
32.95
B
C


ATOM
17136
CG1
ILE
B
555
79.500
21.664
−20.567
1.00
32.79
B
C


ATOM
17139
CD1
ILE
B
555
79.137
23.039
−20.029
1.00
29.41
B
C


ATOM
17143
CG2
ILE
B
555
81.957
22.100
−20.587
1.00
30.93
B
C


ATOM
17147
C
ILE
B
555
82.511
19.220
−20.501
1.00
32.07
B
C


ATOM
17148
O
ILE
B
555
82.789
18.686
−19.434
1.00
30.59
B
O


ATOM
17150
N
LEU
B
556
83.391
19.367
−21.484
1.00
32.81
B
N


ATOM
17151
CA
LEU
B
556
84.761
18.848
−21.362
1.00
34.73
B
C


ATOM
17153
CB
LEU
B
556
85.564
19.045
−22.669
1.00
34.99
B
C


ATOM
17156
CG
LEU
B
556
85.005
18.383
−23.948
1.00
39.49
B
C


ATOM
17158
CD1
LEU
B
556
85.738
18.858
−25.230
1.00
42.15
B
C


ATOM
17162
CD2
LEU
B
556
85.067
16.866
−23.827
1.00
40.24
B
C


ATOM
17166
C
LEU
B
556
85.454
19.540
−20.179
1.00
34.19
B
C


ATOM
17167
O
LEU
B
556
85.268
20.731
−19.971
1.00
35.29
B
O


ATOM
17169
N
PRO
B
557
86.252
18.795
−19.401
1.00
34.37
B
N


ATOM
17170
CA
PRO
B
557
86.764
19.369
−18.152
1.00
34.58
B
C


ATOM
17172
CB
PRO
B
557
87.532
18.209
−17.506
1.00
34.08
B
C


ATOM
17175
CG
PRO
B
557
87.851
17.281
−18.607
1.00
35.29
B
C


ATOM
17178
CD
PRO
B
557
86.815
17.462
−19.685
1.00
34.74
B
C


ATOM
17181
C
PRO
B
557
87.672
20.587
−18.327
1.00
34.93
B
C


ATOM
17182
O
PRO
B
557
88.198
20.847
−19.407
1.00
35.00
B
O


ATOM
17183
N
PHE
B
558
87.827
21.332
−17.245
1.00
35.20
B
N


ATOM
17184
CA
PHE
B
558
88.627
22.539
−17.251
1.00
35.65
B
C


ATOM
17186
CB
PHE
B
558
88.342
23.308
−15.962
1.00
32.90
B
C


ATOM
17189
CG
PHE
B
558
89.329
24.400
−15.656
1.00
35.99
B
C


ATOM
17190
CD1
PHE
B
558
90.270
24.248
−14.636
1.00
38.91
B
C


ATOM
17192
CE1
PHE
B
558
91.172
25.264
−14.339
1.00
40.56
B
C


ATOM
17194
CZ
PHE
B
558
91.140
26.448
−15.062
1.00
39.35
B
C


ATOM
17196
CE2
PHE
B
558
90.208
26.608
−16.074
1.00
38.08
B
C


ATOM
17198
CD2
PHE
B
558
89.311
25.589
−16.367
1.00
36.76
B
C


ATOM
17200
C
PHE
B
558
90.119
22.174
−17.388
1.00
38.66
B
C


ATOM
17201
O
PHE
B
558
90.588
21.221
−16.768
1.00
35.43
B
O


ATOM
17203
N
GLU
B
559
90.841
22.934
−18.210
1.00
43.59
B
N


ATOM
17204
CA
GLU
B
559
92.278
22.725
−18.437
1.00
49.37
B
C


ATOM
17206
CB
GLU
B
559
92.527
22.302
−19.886
1.00
50.25
B
C


ATOM
17209
CG
GLU
B
559
92.467
20.803
−20.151
1.00
55.23
B
C


ATOM
17212
CD
GLU
B
559
92.918
20.460
−21.569
1.00
62.27
B
C


ATOM
17213
OE1
GLU
B
559
92.093
20.605
−22.507
1.00
58.80
B
O


ATOM
17214
OE2
GLU
B
559
94.100
20.059
−21.736
1.00
59.57
B
O


ATOM
17215
C
GLU
B
559
93.083
24.001
−18.161
1.00
52.39
B
C


ATOM
17216
O
GLU
B
559
92.772
25.061
−18.707
1.00
52.68
B
O


ATOM
17218
N
ARG
B
560
94.128
23.886
−17.343
1.00
55.22
B
N


ATOM
17219
CA
ARG
B
560
95.025
25.016
−17.043
1.00
57.60
B
C


ATOM
17221
CB
ARG
B
560
95.966
24.658
−15.890
1.00
58.83
B
C


ATOM
17224
CG
ARG
B
560
95.247
24.332
−14.589
1.00
63.59
B
C


ATOM
17227
CD
ARG
B
560
95.488
25.362
−13.492
1.00
69.13
B
C


ATOM
17230
NE
ARG
B
560
94.390
25.393
−12.522
1.00
75.07
B
N


ATOM
17232
CZ
ARG
B
560
94.070
24.398
−11.686
1.00
78.47
B
C


ATOM
17233
NH1
ARG
B
560
94.752
23.252
−11.675
1.00
78.68
B
N


ATOM
17236
NH2
ARG
B
560
93.047
24.545
−10.847
1.00
78.46
B
N


ATOM
17239
C
ARG
B
560
95.856
25.404
−18.261
1.00
57.16
B
C


ATOM
17240
O
ARG
B
560
95.920
26.575
−18.624
1.00
57.13
B
O


ATOM
17242
O
HOH
W
1
67.396
39.491
−23.826
1.00
20.98
W
O


ATOM
17245
O
HOH
W
2
46.505
15.035
−3.469
1.00
20.88
W
O


ATOM
17248
O
HOH
W
3
36.160
7.031
−16.321
1.00
25.10
W
O


ATOM
17251
O
HOH
W
4
34.395
30.503
−35.530
1.00
17.73
W
O


ATOM
17254
O
HOH
W
5
37.638
17.344
−11.502
1.00
32.45
W
O


ATOM
17257
O
HOH
W
6
65.819
−37.512
3.562
1.00
29.91
W
O


ATOM
17260
O
HOH
W
7
56.866
−34.130
−11.051
1.00
31.56
W
O


ATOM
17263
O
HOH
W
8
43.972
−6.315
−15.500
1.00
23.40
W
O


ATOM
17266
O
HOH
W
9
60.228
−40.852
2.964
1.00
21.46
W
O


ATOM
17269
O
HOH
W
10
43.012
23.511
−17.712
1.00
41.96
W
O


ATOM
17272
O
HOH
W
11
38.135
14.576
−14.888
1.00
28.05
W
O


ATOM
17275
O
HOH
W
12
57.728
−35.432
5.083
1.00
24.61
W
O


ATOM
17278
O
HOH
W
13
57.235
−51.809
−9.446
1.00
34.71
W
O


ATOM
17281
O
HOH
W
14
66.193
38.695
−7.571
1.00
26.05
W
O


ATOM
17284
O
HOH
W
15
36.482
−23.763
3.380
1.00
35.70
W
O


ATOM
17287
O
HOH
W
16
63.221
−40.097
3.528
1.00
27.60
W
O


ATOM
17290
O
HOH
W
17
73.515
25.429
6.453
1.00
49.84
W
O


ATOM
17293
O
HOH
W
18
53.192
45.369
−20.010
1.00
31.15
W
O


ATOM
17296
O
HOH
W
19
77.678
42.352
1.054
1.00
32.86
W
O


ATOM
17299
O
HOH
W
20
48.264
−34.170
15.244
1.00
46.42
W
O


ATOM
17302
O
HOH
W
21
39.547
35.857
−35.345
1.00
19.86
W
O


ATOM
17305
O
HOH
W
22
35.404
−1.739
−16.317
1.00
27.73
W
O


ATOM
17308
O
HOH
W
23
62.314
8.273
−25.549
1.00
44.96
W
O


ATOM
17311
O
HOH
W
24
42.306
22.146
−12.509
1.00
21.07
W
O


ATOM
17314
O
HOH
W
25
41.363
11.085
−35.066
1.00
18.32
W
O


ATOM
17317
O
HOH
W
26
46.155
−26.355
−2.836
1.00
27.33
W
O


ATOM
17320
O
HOH
W
27
73.732
29.702
−30.702
1.00
33.09
W
O


ATOM
17323
O
HOH
W
28
55.875
−54.406
1.824
1.00
32.16
W
O


ATOM
17326
O
HOH
W
29
55.002
28.302
−1.446
1.00
42.39
W
O


ATOM
17329
O
HOH
W
30
45.510
−23.435
−12.887
1.00
39.50
W
O


ATOM
17332
O
HOH
W
31
53.296
48.691
−18.974
1.00
46.53
W
O


ATOM
17335
O
HOH
W
32
65.749
−34.978
8.760
1.00
23.25
W
O


ATOM
17338
O
HOH
W
33
41.864
−40.579
7.567
1.00
27.81
W
O


ATOM
17341
O
HOH
W
34
62.501
38.943
−10.518
1.00
24.84
W
O


ATOM
17344
O
HOH
W
35
62.874
−31.234
17.475
1.00
40.25
W
O


ATOM
17347
O
HOH
W
36
72.629
−36.786
2.592
1.00
26.17
W
O


ATOM
17350
O
HOH
W
37
33.607
7.834
−9.701
1.00
45.87
W
O


ATOM
17353
O
HOH
W
38
77.284
−36.310
−9.186
1.00
41.42
W
O


ATOM
17356
O
HOH
W
39
77.331
43.278
−25.049
1.00
30.11
W
O


ATOM
17359
O
HOH
W
40
39.966
−6.135
−21.236
1.00
39.64
W
O


ATOM
17362
O
HOH
W
41
53.845
−3.289
6.774
1.00
27.25
W
O


ATOM
17365
O
HOH
W
42
39.457
24.448
−15.702
1.00
31.86
W
O


ATOM
17368
O
HOH
W
43
50.941
−47.129
15.355
1.00
37.33
W
O


ATOM
17371
O
HOH
W
44
31.147
15.698
−26.421
1.00
31.90
W
O


ATOM
17374
O
HOH
W
45
75.880
39.481
−22.456
1.00
24.94
W
O


ATOM
17377
O
HOH
W
46
54.871
30.920
−42.208
1.00
31.91
W
O


ATOM
17380
O
HOH
W
47
65.261
−50.315
5.447
1.00
32.59
W
O


ATOM
17383
O
HOH
W
48
71.408
−9.056
−6.457
1.00
27.35
W
O


ATOM
17386
O
HOH
W
49
68.507
−42.622
−19.180
1.00
39.04
W
O


ATOM
17389
O
HOH
W
50
40.635
−32.994
−1.450
1.00
29.96
W
O


ATOM
17392
O
HOH
W
51
43.834
39.340
−19.280
1.00
44.69
W
O


ATOM
17395
O
HOH
W
52
49.324
−10.510
−8.611
1.00
22.83
W
O


ATOM
17398
O
HOH
W
53
73.154
−41.586
−3.585
1.00
28.18
W
O


ATOM
17401
O
HOH
W
54
74.167
−32.081
10.431
1.00
38.80
W
O


ATOM
17404
O
HOH
W
55
32.208
−24.041
27.564
1.00
36.12
W
O


ATOM
17407
O
HOH
W
56
81.358
51.348
−21.846
1.00
36.22
W
O


ATOM
17410
O
HOH
W
57
28.049
−9.147
14.182
1.00
28.08
W
O


ATOM
17413
O
HOH
W
58
53.295
−33.548
−8.420
1.00
32.02
W
O


ATOM
17416
O
HOH
W
59
33.141
−27.930
14.065
1.00
49.40
W
O


ATOM
17419
O
HOH
W
60
73.963
42.850
−22.320
1.00
27.05
W
O


ATOM
17422
O
HOH
W
61
57.737
18.482
−4.811
1.00
40.88
W
O


ATOM
17425
O
HOH
W
62
41.825
42.820
−42.173
1.00
33.38
W
O


ATOM
17428
O
HOH
W
63
32.765
16.578
−23.918
1.00
31.22
W
O


ATOM
17431
O
HOH
W
64
37.857
13.924
−10.555
1.00
34.26
W
O


ATOM
17434
O
HOH
W
65
89.849
19.986
−14.523
1.00
30.80
W
O


ATOM
17437
O
HOH
W
66
28.309
−3.232
7.889
1.00
33.97
W
O


ATOM
17440
O
HOH
W
67
81.027
23.484
4.883
1.00
29.67
W
O


ATOM
17443
O
HOH
W
68
92.000
34.104
−14.235
1.00
25.36
W
O


ATOM
17446
O
HOH
W
69
33.611
−22.981
9.544
1.00
26.38
W
O


ATOM
17449
O
HOH
W
70
69.544
29.746
3.258
1.00
45.00
W
O


ATOM
17452
O
HOH
W
71
33.580
19.200
−28.527
1.00
28.54
W
O


ATOM
17455
O
HOH
W
72
60.973
−6.895
13.133
1.00
51.02
W
O


ATOM
17458
O
HOH
W
73
63.662
−53.195
6.160
1.00
31.10
W
O


ATOM
17461
O
HOH
W
74
40.501
13.400
9.740
1.00
29.39
W
O


ATOM
17464
O
HOH
W
75
31.268
−0.700
−16.248
1.00
38.68
W
O


ATOM
17467
O
HOH
W
76
64.405
12.253
−9.311
1.00
32.15
W
O


ATOM
17470
O
HOH
W
77
51.823
−41.573
−13.076
1.00
38.60
W
O


ATOM
17473
O
HOH
W
78
52.094
−48.948
−6.963
1.00
36.07
W
O


ATOM
17476
O
HOH
W
79
65.280
−37.041
19.710
1.00
36.79
W
O


ATOM
17479
O
HOH
W
80
73.752
−42.738
−1.116
1.00
42.80
W
O


ATOM
17482
O
HOH
W
81
33.127
5.296
2.323
1.00
34.50
W
O


ATOM
17485
O
HOH
W
82
52.917
19.244
−39.930
1.00
38.53
W
O


ATOM
17488
O
HOH
W
83
31.947
−16.214
−2.242
1.00
42.38
W
O


ATOM
17491
O
HOH
W
84
44.466
34.961
−48.175
1.00
39.18
W
O


ATOM
17494
O
HOH
W
85
73.801
10.513
−12.397
1.00
34.17
W
O


ATOM
17497
O
HOH
W
86
56.162
−30.900
13.891
1.00
36.49
W
O


ATOM
17500
O
HOH
W
87
58.302
40.830
−34.099
1.00
38.00
W
O


ATOM
17503
O
HOH
W
88
67.361
57.337
−12.595
1.00
35.90
W
O


ATOM
17506
O
HOH
W
89
36.407
16.844
−14.535
1.00
34.76
W
O


ATOM
17509
O
HOH
W
90
36.526
−2.835
−11.577
1.00
29.09
W
O


ATOM
17512
O
HOH
W
91
63.568
38.471
−8.120
1.00
33.00
W
O


ATOM
17515
O
HOH
W
92
31.876
−24.706
−14.685
1.00
47.13
W
O


ATOM
17518
O
HOH
W
93
57.122
46.180
−41.231
1.00
38.56
W
O


ATOM
17521
O
HOH
W
94
40.989
25.119
−38.866
1.00
34.26
W
O


ATOM
17524
O
HOH
W
95
70.573
35.539
−11.174
1.00
34.26
W
O


ATOM
17527
O
HOH
W
96
67.166
−18.296
−0.056
1.00
21.97
W
O


ATOM
17530
O
HOH
W
97
68.329
−19.165
−2.481
1.00
27.46
W
O


ATOM
17533
O
HOH
W
98
46.453
−46.459
−0.096
1.00
23.67
W
O


ATOM
17536
O
HOH
W
99
64.859
−27.821
−0.476
1.00
23.74
W
O


ATOM
17539
O
HOH
W
100
49.889
−41.983
−4.752
1.00
19.81
W
O


ATOM
17542
O
HOH
W
101
63.104
−35.094
−0.981
1.00
21.48
W
O


ATOM
17545
O
HOH
W
102
46.208
22.160
−21.251
1.00
17.27
W
O


ATOM
17548
O
HOH
W
103
44.240
21.517
−19.373
1.00
18.97
W
O


ATOM
17551
O
HOH
W
104
60.940
−21.568
−0.115
1.00
20.52
W
O


ATOM
17554
O
HOH
W
105
58.540
−23.194
−0.426
1.00
28.03
W
O


ATOM
17557
O
HOH
W
106
52.842
−31.073
−2.319
1.00
18.19
W
O


ATOM
17560
O
HOH
W
107
50.708
−32.784
−1.585
1.00
21.26
W
O


ATOM
17563
O
HOH
W
108
42.573
24.337
−31.730
1.00
23.68
W
O


ATOM
17566
O
HOH
W
109
41.632
−13.280
2.319
1.00
19.40
W
O


ATOM
17569
O
HOH
W
110
40.075
−12.128
0.609
1.00
22.13
W
O


ATOM
17572
O
HOH
W
111
61.623
26.993
−12.882
1.00
31.00
W
O


ATOM
17575
O
HOH
W
112
53.819
33.804
−16.115
1.00
25.71
W
O


ATOM
17578
O
HOH
W
113
45.232
4.296
−9.419
1.00
19.63
W
O


ATOM
17581
O
HOH
W
114
67.086
25.456
−18.731
1.00
20.32
W
O


ATOM
17584
O
HOH
W
115
69.127
−23.507
−5.191
1.00
19.05
W
O


ATOM
17587
O
HOH
W
116
40.100
−27.766
7.117
1.00
26.86
W
O


ATOM
17590
O
HOH
W
117
41.450
14.502
−35.661
1.00
21.87
W
O


ATOM
17593
O
HOH
W
118
39.215
14.175
−36.764
1.00
21.90
W
O


ATOM
17596
O
HOH
W
119
61.445
47.858
−13.974
1.00
30.41
W
O


ATOM
17599
O
HOH
W
120
42.487
−37.324
1.207
1.00
19.42
W
O


ATOM
17602
O
HOH
W
121
41.098
−41.117
0.324
1.00
20.14
W
O


ATOM
17605
O
HOH
W
122
58.612
−35.406
−0.839
1.00
24.21
W
O


ATOM
17608
O
HOH
W
123
50.164
1.626
−14.069
1.00
17.73
W
O


ATOM
17611
O
HOH
W
124
50.992
−34.804
12.341
1.00
30.50
W
O


ATOM
17614
O
HOH
W
125
70.666
34.211
−26.020
1.00
27.41
W
O


ATOM
17617
O
HOH
W
126
57.737
−13.710
−12.328
1.00
35.35
W
O


ATOM
17620
O
HOH
W
127
75.308
25.160
−13.718
1.00
16.25
W
O


ATOM
17623
O
HOH
W
128
60.917
−29.336
2.205
1.00
27.11
W
O


ATOM
17626
O
HOH
W
129
37.974
−12.318
−6.397
1.00
29.33
W
O


ATOM
17629
O
HOH
W
130
63.665
−29.882
−4.118
1.00
31.17
W
O


ATOM
17632
O
HOH
W
131
61.715
−32.330
−8.029
1.00
41.88
W
O


ATOM
17635
O
HOH
W
132
72.648
30.403
−18.375
1.00
23.01
W
O


ATOM
17638
O
HOH
W
133
53.042
17.634
−10.102
1.00
23.18
W
O


ATOM
17641
O
HOH
W
134
60.025
38.653
−17.369
1.00
20.09
W
O


ATOM
17644
O
HOH
W
135
61.712
36.617
−16.767
1.00
26.79
W
O


ATOM
17647
O
HOH
W
136
61.300
41.278
−13.860
1.00
21.09
W
O


ATOM
17650
O
HOH
W
137
62.073
−31.149
7.450
1.00
33.22
W
O


ATOM
17653
O
HOH
W
138
55.630
−21.810
−5.863
1.00
43.72
W
O


ATOM
17656
O
HOH
W
139
42.191
33.282
−26.587
1.00
21.30
W
O


ATOM
17659
O
HOH
W
140
46.789
38.171
−22.658
1.00
44.17
W
O


ATOM
17662
O
HOH
W
141
32.524
32.302
−32.556
1.00
27.94
W
O


ATOM
17665
O
HOH
W
142
83.918
41.902
−15.045
1.00
20.74
W
O


ATOM
17668
O
HOH
W
143
57.939
−30.258
0.884
1.00
32.72
W
O


ATOM
17671
O
HOH
W
144
48.703
−35.022
7.181
1.00
37.63
W
O


ATOM
17674
O
HOH
W
145
66.347
31.640
−19.130
1.00
30.26
W
O


ATOM
17677
O
HOH
W
146
64.998
30.057
−17.211
1.00
22.53
W
O


ATOM
17680
O
HOH
W
147
65.134
27.653
−18.405
1.00
22.78
W
O


ATOM
17683
O
HOH
W
148
66.094
38.403
−18.347
1.00
23.57
W
O


ATOM
17686
O
HOH
W
149
35.459
0.990
18.585
1.00
22.46
W
O


ATOM
17689
O
HOH
W
150
71.717
−45.326
−18.716
1.00
33.34
W
O


ATOM
17692
O
HOH
W
151
50.671
5.704
−4.812
1.00
26.81
W
O


ATOM
17695
O
HOH
W
152
61.207
−27.443
−25.202
1.00
50.62
W
O


ATOM
17698
O
HOH
W
153
74.197
−28.017
−17.761
1.00
32.53
W
O


ATOM
17701
O
HOH
W
154
39.585
−1.129
16.289
1.00
21.92
W
O


ATOM
17704
O
HOH
W
155
62.622
−29.524
−0.090
1.00
32.78
W
O


ATOM
17707
O
HOH
W
156
70.598
−25.384
−3.982
1.00
23.20
W
O


ATOM
17710
O
HOH
W
157
56.563
−33.832
−0.616
1.00
27.25
W
O


ATOM
17713
O
HOH
W
158
51.474
−35.440
−5.147
1.00
26.23
W
O


ATOM
17716
O
HOH
W
159
49.890
−35.190
−2.859
1.00
23.25
W
O


ATOM
17719
O
HOH
W
160
53.387
−33.463
−5.052
1.00
31.52
W
O


ATOM
17722
O
HOH
W
161
64.357
−36.964
7.375
1.00
28.26
W
O


ATOM
17725
O
HOH
W
162
64.771
−39.173
5.737
1.00
31.93
W
O


ATOM
17728
O
HOH
W
163
40.629
−47.274
5.327
1.00
20.11
W
O


ATOM
17731
O
HOH
W
164
49.479
−36.987
8.266
1.00
38.74
W
O


ATOM
17734
O
HOH
W
165
50.017
−31.400
12.975
1.00
31.54
W
O


ATOM
17737
O
HOH
W
166
72.235
−28.166
9.021
1.00
33.15
W
O


ATOM
17740
O
HOH
W
167
75.744
−38.559
−1.129
1.00
34.88
W
O


ATOM
17743
O
HOH
W
168
60.678
−3.886
6.560
1.00
43.68
W
O


ATOM
17746
O
HOH
W
169
54.251
−10.331
7.262
1.00
44.60
W
O


ATOM
17749
O
HOH
W
170
55.713
−14.623
−10.880
1.00
27.94
W
O


ATOM
17752
O
HOH
W
171
34.828
7.528
15.394
1.00
23.35
W
O


ATOM
17755
O
HOH
W
172
30.137
−4.012
5.182
1.00
32.68
W
O


ATOM
17758
O
HOH
W
173
38.389
−13.593
−1.858
1.00
55.11
W
O


ATOM
17761
O
HOH
W
174
36.850
−1.221
17.151
1.00
23.53
W
O


ATOM
17764
O
HOH
W
175
38.073
−28.751
3.642
1.00
47.59
W
O


ATOM
17767
O
HOH
W
176
36.616
−30.178
2.331
1.00
40.67
W
O


ATOM
17770
O
HOH
W
177
42.744
−37.262
9.632
1.00
29.50
W
O


ATOM
17773
O
HOH
W
178
42.616
−35.921
11.849
1.00
42.95
W
O


ATOM
17776
O
HOH
W
179
57.767
−25.689
−1.640
1.00
31.54
W
O


ATOM
17779
O
HOH
W
180
78.821
47.464
−4.619
1.00
41.91
W
O


ATOM
17782
O
HOH
W
181
72.583
36.467
−26.619
1.00
34.41
W
O


ATOM
17785
O
HOH
W
182
58.768
41.958
−26.296
1.00
36.05
W
O


ATOM
17788
O
HOH
W
183
58.524
37.308
−31.915
1.00
27.65
W
O


ATOM
17791
O
HOH
W
184
59.204
34.222
−32.284
1.00
31.17
W
O


ATOM
17794
O
HOH
W
185
67.396
24.341
−21.206
1.00
28.49
W
O


ATOM
17797
O
HOH
W
186
73.538
21.133
−16.293
1.00
20.45
W
O


ATOM
17800
O
HOH
W
187
85.397
37.797
−17.665
1.00
32.53
W
O


ATOM
17803
O
HOH
W
188
63.942
25.997
−4.112
1.00
54.26
W
O


ATOM
17806
O
HOH
W
189
53.679
16.888
−7.621
1.00
33.46
W
O


ATOM
17809
O
HOH
W
190
34.187
3.648
−33.715
1.00
31.20
W
O


ATOM
17812
O
HOH
W
191
38.654
−3.056
−28.664
1.00
31.71
W
O


ATOM
17815
O
HOH
W
192
36.665
19.812
−19.436
1.00
30.48
W
O


ATOM
17818
O
HOH
W
193
38.939
22.647
−22.845
1.00
25.48
W
O


ATOM
17821
O
HOH
W
194
33.628
27.331
−38.304
1.00
38.64
W
O


ATOM
17824
O
HOH
W
195
41.094
33.581
−28.770
1.00
21.68
W
O


ATOM
17827
O
HOH
W
196
37.378
31.618
−27.424
1.00
46.50
W
O


ATOM
17830
O
HOH
W
197
37.702
28.581
−29.110
1.00
25.65
W
O


ATOM
17833
O
HOH
W
198
60.016
20.154
−7.770
1.00
31.81
W
O


ATOM
17836
O
HOH
W
199
44.586
28.481
1.221
1.00
33.43
W
O


ATOM
17839
O
HOH
W
200
38.150
20.885
−9.839
1.00
37.13
W
O


ATOM
17842
O
HOH
W
201
44.203
35.043
−19.031
1.00
37.68
W
O


ATOM
17845
O
HOH
W
202
43.620
33.989
−22.475
1.00
31.80
W
O


ATOM
17848
O
HOH
W
203
56.689
23.953
−42.205
1.00
38.64
W
O


ATOM
17851
O
HOH
W
204
59.706
41.117
−16.030
1.00
22.92
W
O


ATOM
17854
O
HOH
W
205
55.135
39.948
−8.848
1.00
53.09
W
O


END









Example 5
Engineering Populus alba Isoprene Synthase for Improved Activity
This example described methods to identify P. alba isoprene synthase (IspS) variants with increased activity, sites for protein engineering studies were chosen based on the crystal structure of the enzyme. Twenty-five site evaluation libraries (SELs) were analyzed for specific activity, and subsequently ranked according to their performance relative to controls.
I. SEL Plasmid Backbone
The plasmid backbone used to generate the 25 SELs was constructed by QuikChange (Stratagene) PCR on the template pDu39 (see U.S. patent application Ser. No. 12/429,143). The PCR reaction mixtures were as follows: 1 μl pDu39, 5 μl 10× PfuUltra HF buffer, 1 μl dNTPs, 1 μl (50 μM) MEA Hairpin Disrupt (pET) F (Table 4-1), 1 μl (50 μM) MEA Hairpin Disrupt (pET) R (Table 5-1), 2 μl DMSO, 39 μl diH2O, 1 μl PfuUltra HF Polymerase (Stratagene). The PCR Cycling Parameters for QuikChange were as follows: 1. 95° C. 1 min, 2. 95° C. 50 sec, 3. 60° C. 50 sec, 4. 68° C. 7 min, 5. Repeat steps 2-4 for 18 cycles, 6. 68° C. 7 min. The PCR product was treated with 1 μl DpnI (Roche) for 3 hours, and then 1 μl of the entire reaction was transformed into chemically competent E. coli Top10 cells (Invitrogen), recovered, and plated according to the manufacturer's recommendations. The next day, positive colonies were chosen for growth, plasmid purification (Qiagen) and sequencing (Quintara Biosciences). Plasmids which harbored the correct base changes introduced using the Quikchange Site-Directed Mutagenesis Kit (Stratagene) were selected for sequencing of the entire open reading frame to confirm the integrity of the coding sequence. One of these plasmids, pCL201 (see FIGS. 39-41), was selected as the backbone for construction of the 25 SELs (Verdezyne).







TABLE 5-1





Primer sequences
















MEA Hairpin Disrupt
ggagatatacatatggaagcacgtcgc


(pET) F
tctgcgaactacgaacctaa



(SEQ ID NO: 46)


 


MMEA Hairpin Disrupt
ttaggttcgtagttcgcagagcgacgtg


(pET) R
cttccatatgtatatctcc



(SEQ ID NO: 47)


 


T7 Forward
taatacgactcactataggg



(SEQ ID NO: 48)


 


T7 Reverse
gctagttattgctcagcgg



(SEQ ID NO: 49)


 


1000
gcactgtctttccgtctgctgc



(SEQ ID NO: 50)


 


QB1493
cttcggcaacgcatggaaat



(SEQ ID NO: 51)


 


A-rev
ctcgtacaggctcaggatag



(SEQ ID NO: 52)


 


A-rev2
ttacgtcccaacgctcaact



(SEQ ID NO: 53)









II. 25 Site Evaluation Libraries

Sites for the 25 SELs were chosen based upon the crystal structure of P. alba IspS (Example 4). Table 5-2 lists all sites and a description of their putative role within the enzyme. Alterations in surface hydrophobic residues may affect protein folding, solubility or activity. Sites in the “hinge region” are located in a helix that spans the N-terminus and the C-terminus, and may dictate how those two halves of the enzyme interact with each other. Sites in the “negatively charged area” are in a region of the protein with a high density of acidic residues, which may somehow regulate activity. Sites within the “flexible loops” are proximal to the active site, and may affect substrate binding, as would sites that are directly within the active site (see Table 5-2). FIG. 42 shows the structure of an IspS dimer, and FIG. 43 shows a monomer. FIG. 44 shows all 25 sites chosen for SELs in stick diagram on the ribbon diagram backbone of the IspS monomer. SELs were generated in the pCL201 plasmid backbone. Plasmids harboring IspS variants were transformed into BL21 DE3 pLysS (Invitrogen) and delivered as glycerol stocks for subsequent growth and screening. FIG. 45 shows the layout of a typical 96-well plate containing 4 complete libraries to be screened for isoprene production and protein concentration. In some cases, where a specific substitution could not be isolated, a the wild type codon was substituted instead.







TABLE 5-2







Sites for SEL








Description
Sites for SEL





Surface hydrophobic residues
I28, V30, L130, G153, V299, L303,



L469, L494


Hinge region
R198, I229, L260


Negatively charged area
D311, D323


Flexible loops
A443, A453, N454, H515, A519, E525


Active site
F388, N438, E451


Miscellaneous
D345, R528, T536









III. DMAPP Assay

A) Growth and Induction
1. Prepared Patch Plates from Glycerol Stock Plates. Using a V&S 96 pin Replication Tool, cultures were patched onto a LB Agar 35 CMP/50 Kan large patch plates from overnight glycerol stock plates. Plates were incubated at 30° C. overnight for 20 to 24 hr. Cultures can be stored at 4° C. for up to a week.
2. Prepared Overnight Growth Plates. 500 mL of LB 35 CMP/50 Kan media were prepared. 300 μL/well of LB 35 CMP/50 Kan media were dispensed into deep 96 well plates (VWR). Using a V&S Replication Tool, the patch inoculum was transferred into deep 96 well plate by touching the tool pins to respective patch and using a circular motion to coat the pins with inoculum. The media was inoculated by dipping the tool then shaking the pin within the well. The overnight growth plates were sealed using a Breathe-Easier Sealing Membrane (Diversified Biotech). The plates were incubated in a Vertiga Shaking Incubator at 30° C. with shaking at 800 rpm overnight for 16 to 18 hr.
3. Prepared Day Growth Plate. Deep 96 well plates were prepared by dispensing 588 μL/well of LB 35 CMP/50 Kan media. Overnight growth plates were removed from the incubator. Overnight cultures were diluted 50-fold and 12 μL of overnight culture were transferred to day growth plates containing 588 μL/well of LB media containing antibiotics. Overnight growth plates were sealed with new Breathe-Easier Sealing Membranes. Cultures were incubated at 30° C. and 800 rpm for 2.5 hr. Frozen 12 mM IPTG (Sigma) vials were removed from −20° C. and placed in a hood to thaw.
4. OD600 Plate Read of Overnight, Induction, and Harvest. 150 μL 1×PBS were dispensed into 96 well Costar Read Plates (#9017). 50 μL of culture samples were transferred to Read Plates. The OD600 reading was recorded using a Spectramax Plate Reader (Molecular Devices).
5. Induction. Electronic multi-channel pipettors were prepared to dispense 4×20 μL/well of IPTG (if 4× replicates). The multi-dispense option in the electronic pipettor was adjusted if more replicates was necessary. Thawed 12 mM IPTG was poured into 50 mL or 100 mL sterile reservoirs. 20 μL/well of IPTG into each 600 μL/well culture. Overnight growth plates were resealed. Cultures were incubated at 30° C. and 800 rpm for 4 hr. OD600 readings of plates were recorded according instructions above.
6. Harvest. 400 μL of induced culture were transferred to 800 μL Grenier storage plates. Plates were centrifuged at 3300 rpm for 20 min at 2° to 8° C. in a low speed benchtop centrifuge. Supernatants were discarded, pellets should stay in the conical bottom well. Residual supernatants were slapped out onto a paper towel on the benchtop. Plates were sealed with an aluminum foil membrane (Beckman-Coulter). Plates were covered with a plastic plate lid if available. Storage plates were labeled accordingly and stored frozen at −80° C.
B) DMAPP Assay
Plates containing induced cell pellets were removed from the −80° C. freezer and allowed to thaw on the benchtop for 30 minutes prior to lysis. 200 μl of lysis buffer (50 mM Tris pH 8, 25 mM MgCl2, 74 μg/ml DNase I, 250 U/ml lysozyme, 0.1% Tween 20, 0.5 mM PMSF) was added to each pellet, and plates were incubated on an Eppendorf Thermomixer at 25° C. for 30 minutes at 1200 rpm. After lysis, plates were centrifuged at 3450 rpm for 15 minutes at 4° C. Supernatants were then removed and diluted 10-fold prior to DMAPP assay. 80 μl of the diluted supernatant was added to 20 μl of the DMAPP working stock (20 mM DMAPP in 0.1 M Phosphate Buffer pH 8.2, DMAPP triammonium salt, Cayman chemicals) in a Zinsser glass block. Blocks were then sealed with aluminum sealing membranes, and incubated in Thermomixers at 25° C. for 30 minutes at 450 rpm. Reactions were stopped by incubating blocks on Thermomixers at 70° C. for 12 minutes at 450 rpm. GC-MS was then used for headspace measurements to calculate the amount of isoprene produced by each lysates.
Headspace Assay. A sample of 200 μl of the desired culture is inoculated into 2 ml CTC headspace vials (Agilent vial Catalog No. 5188 2753, and cap Catalog No. 5188 2759). The cap was screwed on tightly and the vials were incubated at 37° C. with shaking at 250 rpm. After 30 minutes the vials were removed from the incubator and cooled briefly with ambient tap water. The vials were placed into the CombiPal Headspace auto sampler for analysis by GC-MS. The analysis was performed using an Agilent 6890 GC/MS system interfaced with a CTC Analytics CombiPAL autosampler operating in headspace mode. An Agilent HP-5MS GC/MS column (30 m×0.25 mm; 0.25 μm film thickness) was used for separation of analytes. The sampler was set up to inject 500 μL of headspace gas. The GC/MS method utilized helium as the carrier gas at a flow of 1 ml/min. The injection port was held at 250° C. with a split ratio of 50:1. The oven temperature was held at 37° C. for the 2 min duration of the analysis. The Agilent 5793N mass selective detector was run in single ion monitoring (SIM) mode on m/z 67. The detector was switched off from 1.4 to 1.7 minutes to allow the elution of permanent gases. Under these conditions isoprene (2-methyl-1,3-butadiene) was observed to elute at 1.78 minutes. A calibration table was used to quantify the absolute amount of isoprene and was found to be linear from 1 μg/L to 200 μg/L. The limit of detection was estimated to be 50-100 μg/L using this method.
IV. Rapid ELISA Protocol Using 96-Well PVDF Filter Plates:
Frozen liquid alkaline phosphatase substrate was removed from the freezer and allowed to come to room temperature. PVDF plates (Millipore, Whatman) are pre-wetted by adding 50 μl 50% MeOH per well. Calibration curve samples are prepared in blue PCR plates (Bio-Rad plates are good for low volumes). Normally, 10 μl of 100 ug/ml standard was added to 90 μl TBSD for 1:10 dilution, followed by 1:2 serial dilutions in TBSD. TBSD was 50 mM Tris pH 8, 150 mM NaCl, 0.1% Na deoxycholate (from a 10% w/v solution in 50% EtOH stock), 0.05% Na azide). Samples were prepared in one or more dilutions in blue PCR plate (or suitable low volume plate). 100 μl H2O was added to PVDF plate and removed by vacuum and washed with H2O (2×100 μl). A microtiter plate vacuum manifold, set for 10-15 in. Hg vacuum, was used. 50 μl TBSD was added to PVDF plate. Calibrators and samples were added to the PVDF plate, usually in duplicate, allowed to sit 5 min. or longer, and then removed by vacuum. 50 μl blocking buffer (TBST+1% BSA; TBST was 50 mM Tris pH 8, 150 mM NaCl, 0.1% Tween 80, 0.05% Na azide) was added to the PVDF plate and let sit 15 min. or longer. 1° antibody was prepared in blocking buffer (about 1:2000 dilution, depending on target). 2° antibody in blocking buffer (normally goat anti-rabbit alkaline phosphatase conjugate, 1:2000 dilution). PVDF plate was vacuumed and 50 μl 1° antibody was added. The plate was allowed to sit for 5 min. or longer and then vacuumed. The plate was washed 4 times with 200 μl TBST. The 2° antibody was added at a 1:2000 dilution and allowed to sit for 5 min. or longer and then the 2° antibody was removed by vacuum. The plate was washed 4 times with 200 μl TBST. 120 μl of Alkaline phosphatase substrate solution, p-nitrophenyl phosphate liquid substrate (Sigma #N7653), was added to the plate. Color development was monitored and stop reaction when appropriate, normally 10-30 min. The color reaction was stopped by transferring 80 μl to a clear microtiter plate, or by adding 50 μl 3N NaOH followed by transferring 130 μl to clear microtiter plate. The absorbance of each reaction was read in plate reader at 405 nm. Data was exported as a .txt file and imported into an Excel spreadsheet. The average of calibrator replicates was calculated and standard curves were plotted as A405 (x-axis) and μg/ml (y-axis). Best curve fit were determined using linear, power, or exponential algorithms. For best results, only the calibrator range that corresponded to the sample range was used. Because Excel may have difficulty with the entire calibrator range, multiple smaller ranges may be used. Best curve fit equations were used to calculate concentrations of samples. Optimum antibody concentrations were determined empirically. Usual concentrations ran between 1:1000 and 1:8000, but results may vary with target immunogenicity, animal response, and assay concentration range.
V. Results
Site evaluation libraries were screened for specific activity. The performance of variant molecules was determined by activity on a substrate dimethylallyldiphosphate (DMAPP) per unit weight of the molecule (see above). Variant molecules were ranked relative to the parental molecule. The performance index was calculated as activity per unit weight relative the parental molecule. The parental molecule had a performance index of one, by definition. Activity of the parental molecule was calculated as the average of 22-24 assays of the parental molecule. A performance index greater than one indicates an improved molecule.
The positions of some high performing variants mapped onto the crystal structure of P. alba IspS are shown in FIGS. 46 through 50. These include but are not limited to sites 469 and 494 (surface hydrophobic, see Table 5-2 and FIGS. 46), 443, 453, and 515 (flexible loops, see Table 5-2 and FIG. 47), 323 (negatively charged area, see Table 5-2 and FIG. 48), 229 (hinge region, see Table 5-2 and FIGS. 49), and 536 (miscellaneous, see Table 5-2 and FIG. 50). The specific amino acid changes at these sites include but are not limited to I229V, I229L, D323M, A443S, A453I, A453L, A453N, L469A, L494C, L494G, L494I, L494P, L494V, H515M, T536F, T536Y, T536V, T536I, T536M, T536H, T536C, and T536L. Table 5-3 shows a list of variants at sites based on performance index.
Sites 198, 438, and 451 have a low tolerance for substitution as evidenced by all variants displaying reduced specific activity. Similarly, site 528 shows a low tolerance for substitution, with only a conservative variant lysine residue producing activity similar to the parental arginine.







TABLE 5-3





Performance indices of variants






















performance


performance


site
variant
index
site
variant
index





I28
W
1.53
V30
K
1.06


I28
T
1.25
V30
I
0.90


I28
R
1.05
V30
E
0.86


I28
Y
1.02
V30
W
0.85


I28
G
0.93
V30
Y
0.81


I28
F
0.84
V30
G
0.80


I28
S
0.75
V30
F
0.76


I28
N
0.73
V30
Q
0.72


I28
V
0.72
V30
C
0.72


I28
M
0.72
V30
P
0.67


I28
P
0.71
V30
R
0.65


I28
A
0.71
V30
L
0.65


I28
L
0.68
V30
D
0.64


I28
E
0.59
V30
T
0.61


I28
D
0.57
V30
A
0.60


I28
C
0.53
V30
S
0.60





V30
M
0.57





V30
N
0.53







performance


performance


site
variant
index
site
variant
index





L130
W
1.54
G153
K
1.19


L130
K
1.54
G153
H
1.18


L130
S
1.48
G153
L
1.16


L130
Y
1.37
G153
W
1.08


L130
R
1.30
G153
Y
0.99


L130
V
1.22
G153
N
0.91


L130
I
1.20
G153
R
0.90


L130
E
1.06
G153
S
0.80


L130
D
1.04
G153
Q
0.79


L130
Q
0.96
G153
A
0.75


L130
G
0.95
G153
T
0.74


L130
A
0.93
G153
P
0.72


L130
M
0.87
G153
D
0.72


L130
C
0.81
G153
C
0.69


L130
P
0.43
G153
M
0.68





G153
V
0.64







performance


performance


site
variant
index
site
variant
index





I229
V
4.41
L260
N
1.12


I229
L
3.77
L260
M
1.10


I229
C
1.35
L260
I
1.04


I229
T
1.33
L260
H
0.93


I229
P
1.22
L260
V
0.67


I229
N
1.04
L260
W
0.40


I229
S
0.92
L260
Q
0.37


I229
W
0.85
L260
A
0.34


I229
Q
0.69
L260
P
0.32


I229
F
0.60
L260
Y
0.30


I229
M
0.56
L260
G
0.22


I229
E
0.54
L260
K
0.15


I229
A
0.48
L260
S
0.11


I229
H
0.47
L260
E
0.07


I229
G
0.45
L260
T
0.05


I229
Y
0.42
L260
R
0.05


I229
K
0.24
L260
D
0.03


I229
D
0.17


I229
R
0.07







performance


performance


site
variant
index
site
variant
index





R198
D
0.68
V299
L
0.978


R198
G
0.39
V299
A
0.346


R198
V
0.36
V299
T
0.318


R198
T
0.19
V299
S
0.130


R198
S
0.15
V299
M
0.115


R198
H
0.15
V299
N
0.101


R198
A
0.11
V299
K
0.068


R198
C
0.11
V299
R
0.061


R198
I
0.10
V299
W
0.056


R198
M
0.09
V299
G
0.050


R198
N
0.03
V299
H
0.042


R198
F
0.02
V299
E
0.040


R198
Y
0.02
V299
Y
0.032


R198
H
0.01
V299
D
0.025


R198
L
0.01
V299
P
0.00







performance


performance


site
variant
index
site
variant
index





D311
M
3.10
D323
M
1.92


D311
F
1.46
D323
W
1.76


D311
L
1.23
D323
Y
1.38


D311
G
1.22
D323
F
1.33


D311
I
1.21
D323
I
1.27


D311
A
1.12
D323
S
1.22


D311
T
1.10
D323
V
1.10


D311
R
1.08
D323
N
1.07


D311
V
1.06
D323
A
1.03


D311
E
1.02
D323
G
1.03


D311
K
0.95
D323
Q
1.03


D311
S
0.89
D323
K
1.00


D311
W
0.82
D323
T
0.97


D311
Q
0.67
D323
L
0.93





D323
C
0.92





D323
R
0.90





D323
E
0.75







performance


performance


site
variant
index
site
variant
index





D345
Y
0.84
L303
I
1.11


D345
I
0.73
L303
M
1.07


D345
K
0.69
L303
V
0.93


D345
L
0.65
L303
C
0.85


D345
E
0.61
L303
S
0.78


D345
N
0.58
L303
E
0.77


D345
T
0.56
L303
W
0.74


D345
Q
0.56
L303
T
0.71


D345
G
0.55
L303
P
0.71


D345
V
0.51
L303
H
0.59


D345
A
0.50
L303
Q
0.58


D345
W
0.46
L303
G
0.55


D345
C
0.43
L303
D
0.54


D345
M
0.43
L303
A
0.52


D345
S
0.41
L303
R
0.49


D345
R
0.40


D345
P
0.35







performance


performance


site
variant
index
site
variant
index





A443
S
1.79
E451
G
0.16


A443
G
1.28
E451
K
0.15


A443
R
1.19
E451
S
0.14


A443
Q
1.01
E451
I
0.13


A443
H
0.28
E451
H
0.13


A443
L
0.27
E451
Q
0.13


A443
N
0.24
E451
V
0.12


A443
F
0.24
E451
L
0.12


A443
I
0.18
E451
F
0.12


A443
V
0.18
E451
Y
0.12


A443
T
0.12
E451
W
0.12


A443
P
0.10
E451
T
0.12





E451
D
0.12





E451
R
0.11





E451
N
0.10





E451
C
0.09





E451
A
0.09





E451
P
0.08







performance


performance


site
variant
index
site
variant
index





F388
L
1.06
N438
W
1.02


F388
Y
0.88
N438
K
0.34


F388
H
0.73
N438
P
0.31


F388
P
0.26
N438
I
0.29


F388
K
0.25
N438
R
0.28


F388
S
0.25
N438
V
0.20


F388
T
0.25
N438
Q
0.20


F388
Q
0.18
N438
L
0.19


F388
V
0.15
N438
M
0.18


F388
G
0.10
N438
S
0.17


F388
R
0.09
N438
H
0.16


F388
C
0.09
N438
Y
0.15


F388
D
0.09
N438
F
0.14


F388
A
0.08
N438
T
0.13





N438
C
0.12





N438
E
0.12





N438
G
0.11





N438
A
0.11





N438
D
0.11







performance


performance


site
variant
index
site
variant
index





N454
S
0.49
L494
P
2.64


N454
G
0.33
L494
C
1.89


N454
H
0.28
L494
I
1.71


N454
T
0.24
L494
V
1.57


N454
D
0.20
L494
S
1.38


N454
A
0.15
L494
G
1.30


N454
E
0.14
L494
D
1.04


N454
Q
0.11
L494
E
0.87


N454
L
0.05
L494
H
0.70


N454
W
0.05
L494
K
0.68


N454
F
0.03
L494
Y
0.66


N454
I
0.03
L494
Q
0.63


N454
Y
0.02
L494
N
0.58


N454
V
0.02
L494
R
0.41


N454
R
0.02
L494
A
0.39


N454
C
0.02
L494
W
0.37


N454
P
0.02
L494
T
0.08


N454
M
0.02







performance


performance


site
variant
index
site
variant
index





L469
A
1.45
A453
N
2.99


L469
Q
1.06
A453
I
1.77


L469
S
0.97
A453
V
1.08


L469
L
0.96
A453
T
0.53


L469
R
0.78
A453
Y
0.43


L469
I
0.75
A453
E
0.39


L469
V
0.74
A453
H
0.37


L469
C
0.71
A453
F
0.35


L469
H
0.66
A453
C
0.35


L469
T
0.63
A453
S
0.34


L469
F
0.60
A453
W
0.22


L469
N
0.57
A453
R
0.21


L469
Y
0.47
A453
D
0.10


L469
W
0.42
A453
K
0.05


L469
P
0.35
A453
P
0.03


L469
G
0.01
A453
G
0.02







performance


performance


site
variant
index
site
variant
index





A519
H
1.41
E525
S
1.62


A519
S
1.27
E525
T
1.25


A519
G
1.21
E525
R
1.24


A519
W
1.17
E525
K
1.22


A519
T
1.12
E525
V
1.17


A519
K
0.93
E525
H
1.09


A519
F
0.78
E525
L
1.07


A519
R
0.61
E525
F
1.05


A519
C
0.60
E525
W
1.05


A519
Q
0.58
E525
Q
1.05


A519
E
0.44
E525
G
1.00


A519
Y
0.42
E525
M
0.95


A519
V
0.40
E525
C
0.92


A519
L
0.39
E525
A
0.91


A519
D
0.23
E525
P
0.74


A519
P
0.04
E525
N
0.71





E525
D
0.68







performance


performance


site
variant
index
site
variant
index





H515
M
2.00
R528
K
1.00


H515
Q
1.05
R528
F
0.58


H515
N
0.97
R528
H
0.49


H515
R
0.97
R528
M
0.46


H515
G
0.93
R528
V
0.45


H515
H
0.81
R528
L
0.25


H515
Y
0.75
R528
Y
0.23


H515
I
0.72
R528
T
0.21


H515
A
0.71
R528
C
0.21


H515
E
0.64
R528
E
0.20


H515
F
0.59
R528
S
0.17


H515
D
0.59
R528
A
0.16


H515
L
0.58
R528
N
0.15


H515
V
0.56
R528
G
0.11


H515
C
0.50
R528
W
0.07


H515
T
0.50
R528
D
0.05


H515
W
0.43
R528
P
0.02


H515
S
0.38


H515
P
0.03
















performance



site
variant
index







T536
F
3.60



T536
Y
2.62



T536
V
2.56



T536
I
2.44



T536
M
1.62



T536
H
1.50



T536
C
1.48



T536
L
1.43



T536
K
1.37



T536
A
1.31



T536
S
1.29



T536
G
1.04



T536
R
0.96



T536
N
0.55



T536
E
0.22



T536
D
0.18



T536
P
0.05










The entire library of T536, variants from all SELs which displayed the highest performance indices, and some control variants which displayed low performance indices were re-assayed for activity as described above. Table 5-4 shows the results from these assays. Results are presented as performance vs. wild-type (unmodified) molecule. Wild-type performance was determined as the average of 51 separate grown cultures. Results were variable between assays but results were in very good agreement with the primary screen results, indicating the assay is reliable. Beneficial sites for variation include but are not limited to flexible loop sites A453, H515, and A443; hydrophobic surface sites L494 and L469 and miscellaneous site T536. The highest performing variants, i.e. those that displayed a performance index greater than 1.5, were A453N, T536C, L494P, T5361, T536F, T536Y, and L494C.







TABLE 5-4







Performance indices of following retest.













performance



site
variant
index







A453
N
2.31



T536
C
1.88



L494
P
1.82



T536
I
1.73



T536
F
1.73



T536
Y
1.73



L494
C
1.56



T536
A
1.48



L494
V
1.48



T536
K
1.46



T536
L
1.46



L494
G
1.39



T536
R
1.36



H515
M
1.34



A453
I
1.31



T536
V
1.27



A443
S
1.16



L494
I
1.10



T536
M
1.09



L469
A
1.09



D323
M
0.95



T536
H
0.94



T536
G
0.90



I229
V
0.89



I229
L
0.89



T536
S
0.72



T536
N
0.49



T536
D
0.17



T536
E
0.16



E451
S
0.14



R528
D
0.11



N438
E
0.10



E451
I
0.08



T536
P
0.08



R528
P
0.05










Example 6
P. alba Isoprene Synthase Combinatorial Analysis, Expression, Crystallization, Activity, and Tm
The P. alba isoprene synthase (IspS) SEL and enrichment studies identified several independent mutations displaying higher in vitro activity than the wild type (WT) enzyme. The experiments described below were aimed to determine if these mutations were mutually beneficial in combination with one another, and to determine if there were additional beneficial biochemical properties of any of the more active variants.
Methods
Three P. alba Isoprene Synthase (IspS) variants which demonstrated high performance index values relative to wild type in the SEL activity assay were chosen for further study. A fourth variant, previously isolated by a selection for randomly mutagenized IspS enzymes that tolerated protracted, high MVA pathway flux, was also included in the combinatorial analysis. These four variants harbored the mutations A453N, G491S (previously referred to as G507S), L494P, and T536C. In all possible combinations, these four mutations generated 16 possible variants of IspS. For ease of reference, the 16 variants to be assayed were annotated as containing the possible combinations of mutations N (A453N), S (G491S), P (L494P), or C (T536C), or WT (no mutations) in a given IspS molecule.
The 16 variants were based upon the vector backbone MD09-163 (encoding the WT enzyme, see FIG. 60), which harbors a TEV protease site and 6×His tag at the C-terminal end of IspS. Variants were generated using the QuikChange Multi Site-Directed Mutagenesis Kit (Stratagene) according to the manufacturer's recommended protocol (see below for PCR reaction and cycling parameters). Since the mutations encoding G491S and L494P are within six nucleotides of each other, it was necessary to use an oligonucleotide harboring both mutations in addition to the single oligonucleotides for those mutations in the QuikChange Multi reaction in order to generate all 16 possible combinations of mutations. The QuikChange Multi reaction was transformed into chemically competent E. coli TOP10 cells (Invitrogen) according to the manufacturer's recommended protocol and plated onto LB Kan50 selective media plates. Colonies resistant to kanamycin were directly screened by PCR and verified by sequencing using the primers QB1493 and T7 Reverse (Quintara Biosciences). In some cases, if a certain variant was not isolated from the QuickChange Multi reaction, a modified version of QuikChange Mutagenesis (Stratagene) was employed to generate a given variant (see below for PCR reaction and cycling parameters). These two techniques yielded all 16 possible combinatorial variants of N, S, P, or C, which were subjected to complete sequencing using the primers T7 Forward, EL-1000, QB1493, A-rev, A-rev2, and T7 Reverse (see Table 6-1). TOP10 cells were grown in selective medium, and plasmids were purified (Qiagen) and then transformed into chemically competent BL21 DE3 pLysS (Invitrogen) according to the manufacturer's recommended protocol, prior to expression of the IspS variants. All variants of IspS were purified and analyzed for specific activity relative to WT (see FIG. 62).
In a separate set of constructs, the T536F mutation (shown to be a thermostable variant of IspS) was also introduced into both the MD09-163 and pDW101 backbones. This mutation was introduced by the QuikChange mutagenesis methodology described above (see below for PCR reaction and cycling parameters), and similarly transformed into BL21 DE3 pLysS (Invitrogen) for expression. These variants were assayed for their effect on IspS expression and melting point relative to WT.
QuikChange Multi Site-Directed Mutagenesis
9 μl H2O
2.5 μl 10× QuikChange Multi reaction buffer
0.5 μl QuikSolution
1 μl DNA template (100 ng MD09-163)
2 μl each primer (200 ng each of N, S, P, C, SP)
1 μl dNTP mix
1 μl QuikChange Multi enzyme blend
QuikChange Multi Site-Directed Mutagenesis—Cycling Parameters
1) 95° C.—4 min
2) 95° C.—1 min
3) 53° C.—1 min
4) 65° C.—14 min
5) goto Step 2—30×
6) 4° C.—for holding
QuikChange Mutagenesis (modified)
35 μl H2O
5 μl 10×Pfu Ultra II r×n Buffer
6 μl 2.5 mM dNTPs (Roche)
1 μl 20 μM Primer 1 (e.g. G507S QC 2 For or alba T536F For)
1 μl 20 μM Primer 2 (e.g. G507S QC 2 Rev or alba T536F Rev)
1 μl Pfu Ultra II HS Polymerase (Stratagene)
1 μl DNA template (e.g. 100 ng MD09-163 or pDW101)
QuikChange Mutagenesis—Cycling Parameters
1) 95° C.—4 min
2) 95° C.—20 sec
3) 52° C.—20 sec
4) 68° C.—7 min
5) goto Step 2—5×
6) 95° C.—20 sec
7) 55° C.—20 sec
8) 68° C.—7 min
9) goto Step 2—20×
10) 68° C.—10 min
11) 4° C.—for holding







TABLE 6-1





Primers
















alba A453N For 
gcgcgtggtgaaaccaacaatagcgtttctt


(N)
gttac (SEQ ID NO: 54)


 


QC G507S For (S)
agatgaacaaggaaaaactgagtggtagcct



gttcgcgaaa (SEQ ID NO: 55)


 


alba L494P For 
gaaaaactgggtggtagcccgttcgcgaaac


(P)
cgttcg (SEQ ID NO: 56)


 


alba T536C For 
gttctgtctgtaatctgcgaaccgattctgc


(C)
cgtttg (SEQ ID NO: 57)


 


alba G491S L494P
gaacaaggaaaaactgagtggtagccc


For (SP)
gttcgcgaaaccgttcg



(SEQ ID NO: 58)


 


G507S QC 2 For
gaaaaactgagtggtagcctgttcgcgaaac



(SEQ ID NO: 59)


 


G507S QC 2 Rev
aggctaccactcagtttttccttgttcatct



(SEQ ID NO: 60)


 


alba T536F For
gttctgtctgtaatctttgaaccgattctgc



cgtttg (SEQ ID NO: 61)


 


alba T536F Rev
cggttcaaagattacagacagaacgcgtt



(SEQ ID NO: 62)


 


T7 Forward
taatacgactcactataggg



(SEQ ID NO: 48)


 


T7 Reverse
gctagttattgctcagcgg



(SEQ ID NO: 49)


 


EL-1000
gcactgtctttccgtctgctgc



(SEQ ID NO: 50)


 


A-rev
ctcgtacaggctcaggatag



(SEQ ID NO: 52)


 


A-rev-2
ttacgtcccaacgctcaact



(SEQ ID NO: 53)


 


QB1493
cttcggcaacgcatggaaat



(SEQ ID NO: 51)
















TABLE 6-2





Plasmids:
















MD09-163
pET24a-P. alba TRC (MEA WT) C-Term (+) TEV, His tag


pDW87
pET24a-P. alba TRC (MEA T536F) C-Term (+) TEV, His tag


pDW95
pET24a-P. alba TRC (MEA L494P T536F) C-Term (+) TEV, His tag


pDW99
pET24a-P. alba TRC (MEA A453N) C-Term (+) TEV, His tag


pDW100
pET24a-P. alba TRC (MEA G491S) C-Term (+) TEV, His tag


pDW101
pET24a-P. alba TRC (MEA L494P) C-Term (+) TEV, His tag


pDW102
pET24a-P. alba TRC (MEA T536C) C-Term (+) TEV, His tag


pDW103
pET24a-P. alba TRC (MEA A453N G491S) C-Term (+) TEV, His tag


pDW104
pET24a-P. alba TRC (MEA A453N L494P) C-Term (+) TEV, His tag


pDW105
pET24a-P. alba TRC (MEA A453N T536C) C-Term (+) TEV, His tag


pDW106
pET24a-P. alba TRC (MEA A453N G491S L494P) C-Term (+) TEV, His



tag


pDW107
pET24a-P. alba TRC (MEA A453N G491S T536C) C-Term (+) TEV, His



tag


pDW108
pET24a-P. alba TRC (MEA A453N L494P T536C) C-Term (+) TEV, His



tag


pDW109
pET24a-P. alba TRC (MEA A453N G491S L494P T536C) C-Term (+)



TEV, His tag


pDW110
pET24a-P. alba TRC (MEA G491S L494P) C-Term (+) TEV, His tag


pDW111
pET24a-P. alba TRC (MEA G491S T536C) C-Term (+) TEV, His tag


pDW112
pET24a-P. alba TRC (MEA G491S L494P T536C) C-Term (+) TEV, His



tag


pDW113
pET24a-P. alba TRC (MEA L494P T536C) C-Term (+) TEV, His tag
















TABLE 6-3





Strains:


















MD09-167
BL21(DE3) pLysS, MD09-163 (WT)



DW363
BL21(DE3) pLysS, pDW87



DW381
BL21(DE3) pLysS, pDW95



DW397
BL21(DE3) pLysS, pDW99 (N)



DW398
BL21(DE3) pLysS, pDW100 (S)



DW399
BL21(DE3) pLysS, pDW101 (P)



DW400
BL21(DE3) pLysS, pDW102 (C)



DW401
BL21(DE3) pLysS, pDW103 (NS)



DW402
BL21(DE3) pLysS, pDW104 (NP)



DW403
BL21(DE3) pLysS, pDW105 (NC)



DW404
BL21(DE3) pLysS, pDW106 (NSP)



DW405
BL21(DE3) pLysS, pDW107 (NSC)



DW406
BL21(DE3) pLysS, pDW108 (NPC)



DW407
BL21(DE3) pLysS, pDW109 (NSPC)



DW408
BL21(DE3) pLysS, pDW110 (SP)



DW409
BL21(DE3) pLysS, pDW111 (SC)



DW410
BL21(DE3) pLysS, pDW112 (SPC)



DW411
BL21(DE3) pLysS, pDW1113 (PC)

















1) Amino Acid Sequence of P. alba MEA(+)TEV −


MD09-163 (WT) (SEQ ID NO: 63)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVITEPILPFERENLYFQGLEHHHHHH













DNA sequence of MD09-163 (SEQ ID NO: 64)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgggtggtagcctgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













2) Amino Acid Sequence of P. alba MEA A453N (+)


TEV − pDW99 (N) (SEQ ID NO: 65)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSITEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW99 (SEQ ID NO: 66)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccAACaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgggtggtagcctgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













3) Amino Acid Sequence of P. alba MEA G491S (+)


TEV − pDW100 (S) (SEQ ID NO: 67)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLSGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVITEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW100 (SEQ ID NO: 68)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgAGTggtagcctgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













4) Amino Acid Sequence of P. alba MEA L494P (+)


TEV − pDW101 (P) (SEQ ID NO: 69)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLGGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVITEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW101 (SEQ ID NO: 70)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgggtggtagcCCGttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













5) Amino Acid Sequence of P. alba MEA T536C (+)


TEV − pDW102 (C) (SEQ ID NO: 71)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVICEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW102 (SEQ ID NO: 72)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgggtggtagcctgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatcTGCgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













6) Amino Acid Sequence of P. alba MEA A453N 


G491S (+)TEV − pDW103 (NS) (SEQ ID NO: 73)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLSGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVITEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW103 (SEQ ID NO: 74)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcg


 








acgatatctacgatgtatacggcaccctggacgaactggagctgttta



 


ctgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgg



 


attacatgaaactgtgctttctggctctgtataacactattaacgaaa



 


tcgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatc



 


tgaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagcca



 


agtggctgtacaacaaatctactccgacctttgacgactacttcggca



 


acgcatggaaatcctcttctggcccgctgcaactggtgttcgcttact



 


tcgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaa



 


aataccatgacaccatctctcgtccttcccatatcttccgtctgtgca



 


atgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaaca



 


atagcgtttcttgttacatgcgcactaaaggtatctccgaagaactgg



 


ctaccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatga



 


acaaggaaaaactgAGTggtagcctgttcgcgaaaccgttcgtggaaa



 


ccgcgatcaacctggcacgtcaatctcactgcacttatcataacggcg



 


acgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctg



 


taatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttc



 


agggcctcgagcaccaccaccaccaccactgagatccggctgctaaca



 


aagcccgaaaggaagctgagttggctgctgccaccgctgagcaataac



 


tagcataaccccttggggcctctaaacgggtcttgaggggttttttgc



 


tgaaaggaggaactatatccggat














7) Amino Acid Sequence of P. alba MEA A453N


L494P (+)TEV − pDW104 (NP) (SEQ ID NO: 75)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLGGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVITEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW104 (SEQ ID NO: 76)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaacaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgggtggtagcccgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













8) Amino Acid Sequence of P. alba MEA A453N 


T536C (+)TEV − pDW105 (NC) (SEQ ID NO: 77)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVICEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW105 (SEQ ID NO: 78)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaacaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgggtggtagcctgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













9) Amino Acid Sequence of P. alba MEA A453N 


G491S L494P (+)TEV − pDW106 (NSP) (SEQ ID NO:


79)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLSGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVITEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW106 (SEQ ID NO: 80)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaacaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgagtggtagcccgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













10) Amino Acid Sequence of P. alba MEA A453N 


G491S T536C (+)TEV − pDW107 (NSC) (SEQ ID NO:


81)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLSGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVICEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW107 (SEQ ID NO: 82)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaacaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgagtggtagcctgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













11) Amino Acid Sequence of P. alba MEA A453N 


L494P T536C (+)TEV − pDW108 (NPC) (SEQ ID NO:


83)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLGGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVICEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW108 (SEQ ID NO: 84)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaacaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgggtggtagcccgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













12) Amino Acid Sequence of P. alba MEA A453N 


G491S L494P T536C (+)TEV − pDW109 (NSPC)


(SEQ ID NO: 85)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETNNSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLSGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVICEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW109 (SEQ ID NO: 86)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccaacaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgagtggtagcccgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













13) Amino Acid Sequence of P. alba MEA


G491S L494P (+)TEV − pDW110 (SP)


(SEQ ID NO: 87)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLSGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVITEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW110 (SEQ ID NO: 88)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgagtggtagcccgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatcactgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













14) Amino Acid Sequence of P. alba MEA G491S


T536C (+)TEV − pDW111 (SC) (SEQ ID NO: 89)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLSGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVICEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW111 (SEQ ID NO: 90)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgagtggtagcctgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













15) Amino Acid Sequence of P. alba MEA G491S 


L494P T536C (+)TEV − pDW112 (SPC) (SEQ ID NO:


91)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLSGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVICEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW112 (SEQ ID NO: 92)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


aatgggcccgctaacagcgcgatttgctggtgacccaatgcgaccaga


 


tgctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactg


 


ttgatgggtgtctggtcagagacatcaagaaataacgccggaacatta


 


gtgcaggcagcttccacagcaatggcatcctggtcatccagcggatag


 


ttaatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgcc


 


gctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacg


 


ctggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgc


 


gacggcgcgtgcagggccagactggaggtggcaacgccaatcagcaac


 


gactgtttgcccgccagttgttgtgccacgcggttgggaatgtaattc


 


agctccgccatcgccgcttccactttttcccgcgttttcgcagaaacg


 


tggctggcctggttcaccacgcgggaaacggtctgataagagacaccg


 


gcatactctgcgacatcgtataacgttactggtttcacattcaccacc


 


ctgaattgactctcttccgggcgctatcatgccataccgcgaaaggtt


 


ttgcgccattcgatggtgtccgggatctcgacgctctcccttatgcga


 


ctcctgcattaggaagcagcccagtagtaggttgaggccgttgagcac


 


cgccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtcc


 


cccggccacggggcctgccaccatacccacgccgaaacaagcgctcat


 


gagcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgat


 


ataggcgccagcaaccgcacctgtggcgccggtgatgccggccacgat


 


gcgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacga


 


ctcactataggggaattgtgagcggataacaattcccctctagaaata


 


attttgtttaactttaagaaggagatatacatatggaagctcgtcgtt


 


ctgcgaactacgaacctaacagctgggactatgattacctgctgtcct


 


ccgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagc


 


tggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttc


 


tgaccctgctggaactgattgacaacgtccagcgcctgggcctgggtt


 


accgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcct


 


ccggcggcttcgatgcggtaaccaagacttccctgcacggtacggcac


 


tgtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaag


 


cgttcagcggcttcaaagaccaaaacggcaacttcctggagaacctga


 


aggaagatatcaaagctatcctgagcctgtacgaggccagcttcctgg


 


ctctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatct


 


ctcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcag


 


aacaggtgaaccatgcactggaactgccactgcatcgccgtactcagc


 


gtctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacg


 


cgaatcaggttctgctggagctggcaattctggattacaacatgatcc


 


agtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtc


 


gtgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattg


 


agagcttctactgggccgtgggtgtagcattcgaaccgcaatactccg


 


actgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcg


 


acgatatctacgatgtatacggcaccctggacgaactggagctgttta


 


ctgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgg


 


attacatgaaactgtgctttctggctctgtataacactattaacgaaa


 


tcgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatc


 


tgaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagcca


 


agtggctgtacaacaaatctactccgacctttgacgactacttcggca


 


acgcatggaaatcctcttctggcccgctgcaactggtgttcgcttact


 


tcgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaa


 


aataccatgacaccatctctcgtccttcccatatcttccgtctgtgca


 


atgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaa


 


atagcgtttcttgttacatgcgcactaaaggtatctccgaagaactgg


 


ctaccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatga


 


acaaggaaaaactgagtggtagcccgttcgcgaaaccgttcgtggaaa


 


ccgcgatcaacctggcacgtcaatctcactgcacttatcataacggcg


 


acgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctg


 


taatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttc


 


agggcctcgagcaccaccaccaccaccactgagatccggctgctaaca


 


aagcccgaaaggaagctgagttggctgctgccaccgctgagcaataac


 


tagcataaccccttggggcctctaaacgggtcttgaggggttttttgc


 


tgaaaggaggaactatatccggat













16) Amino Acid Sequence of P. alba MEA L494P


T536C (+)TEV − pDW113 (PC) (SEQ ID NO: 93)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLGGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVICEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW113 (SEQ ID NO: 94)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgggtggtagcccgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatctgcgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













Amino Acid Sequence of P. alba MEA T536F


(+)TEV − pDW87 (SEQ ID NO: 95)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLGGSLFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVIFEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW87 (SEQ ID NO: 96)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgggtggtagcctgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatctttgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat













Amino Acid Sequence of P. alba MEA L494P


T536F (+)TEV − pDW95 (SEQ ID NO: 97)


MEARRSANYEPNSWDYDYLLSSDTDESIEVYKDKAKKLEAEVRREINN


 


EKAEFLTLLELIDNVQRLGLGYRFESDIRGALDRFVSSGGFDAVTKTS


 


LHGTALSFRLLRQHGFEVSQEAFSGFKDQNGNFLENLKEDIKAILSLY


 


EASFLALEGENILDEAKVFAISHLKELSEEKIGKELAEQVNHALELPL


 


HRRTQRLEAVWSIEAYRKKEDANQVLLELAILDYNMIQSVYQRDLRET


 


SRWWRRVGLATKLHFARDRLIESFYWAVGVAFEPQYSDCRNSVAKMFS


 


FVTIIDDIYDVYGTLDELELFTDAVERWDVNAINDLPDYMKLCFLALY


 


NTINEIAYDNLKDKGENILPYLTKAWADLCNAFLQEAKWLYNKSTPTF


 


DDYFGNAWKSSSGPLQLVFAYFAVVQNIKKEEIENLQKYHDTISRPSH


 


IFRLCNDLASASAEIARGETANSVSCYMRTKGISEELATESVMNLIDE


 


TWKKMNKEKLGGSPFAKPFVETAINLARQSHCTYHNGDAHTSPDELTR


 


KRVLSVIFEPILPFERENLYFQGLEHHHHHH













DNA sequence of pDW95 (SEQ ID NO: 98)


tggcgaatgggacgcgccctgtagcggcgcattaagcgcggcgggtgt


 


ggtggttacgcgcagcgtgaccgctacacttgccagcgccctagcgcc


 


cgctcctttcgctttcttcccttcctttctcgccacgttcgccggctt


 


tccccgtcaagctctaaatcgggggctccctttagggttccgatttag


 


tgctttacggcacctcgaccccaaaaaacttgattagggtgatggttc


 


acgtagtgggccatcgccctgatagacggtttttcgccctttgacgtt


 


ggagtccacgttctttaatagtggactcttgttccaaactggaacaac


 


actcaaccctatctcggtctattcttttgatttataagggattttgcc


 


gatttcggcctattggttaaaaaatgagctgatttaacaaaaatttaa


 


cgcgaattttaacaaaatattaacgtttacaatttcaggtggcacttt


 


tcggggaaatgtgcgcggaacccctatttgtttatttttctaaataca


 


ttcaaatatgtatccgctcatgaattaattcttagaaaaactcatcga


 


gcatcaaatgaaactgcaatttattcatatcaggattatcaataccat


 


atttttgaaaaagccgtttctgtaatgaaggagaaaactcaccgaggc


 


agttccataggatggcaagatcctggtatcggtctgcgattccgactc


 


gtccaacatcaatacaacctattaatttcccctcgtcaaaaataaggt


 


tatcaagtgagaaatcaccatgagtgacgactgaatccggtgagaatg


 


gcaaaagtttatgcatttctttccagacttgttcaacaggccagccat


 


tacgctcgtcatcaaaatcactcgcatcaaccaaaccgttattcattc


 


gtgattgcgcctgagcgagacgaaatacgcgatcgctgttaaaaggac


 


aattacaaacaggaatcgaatgcaaccggcgcaggaacactgccagcg


 


catcaacaatattttcacctgaatcaggatattcttctaatacctgga


 


atgctgttttcccggggatcgcagtggtgagtaaccatgcatcatcag


 


gagtacggataaaatgcttgatggtcggaagaggcataaattccgtca


 


gccagtttagtctgaccatctcatctgtaacatcattggcaacgctac


 


ctttgccatgtttcagaaacaactctggcgcatcgggcttcccataca


 


atcgatagattgtcgcacctgattgcccgacattatcgcgagcccatt


 


tatacccatataaatcagcatccatgttggaatttaatcgcggcctag


 


agcaagacgtttcccgttgaatatggctcataacaccccttgtattac


 


tgtttatgtaagcagacagttttattgttcatgaccaaaatcccttaa


 


cgtgagttttcgttccactgagcgtcagaccccgtagaaaagatcaaa


 


ggatcttcttgagatcctttttttctgcgcgtaatctgctgcttgcaa


 


acaaaaaaaccaccgctaccagcggtggtttgtttgccggatcaagag


 


ctaccaactctttttccgaaggtaactggcttcagcagagcgcagata


 


ccaaatactgtccttctagtgtagccgtagttaggccaccacttcaag


 


aactctgtagcaccgcctacatacctcgctctgctaatcctgttacca


 


gtggctgctgccagtggcgataagtcgtgtcttaccgggttggactca


 


agacgatagttaccggataaggcgcagcggtcgggctgaacggggggt


 


tcgtgcacacagcccagcttggagcgaacgacctacaccgaactgaga


 


tacctacagcgtgagctatgagaaagcgccacgcttcccgaagggaga


 


aaggcggacaggtatccggtaagcggcagggtcggaacaggagagcgc


 


acgagggagcttccagggggaaacgcctggtatctttatagtcctgtc


 


gggtttcgccacctctgacttgagcgtcgatttttgtgatgctcgtca


 


ggggggcggagcctatggaaaaacgccagcaacgcggcctttttacgg


 


ttcctggccttttgctggccttttgctcacatgttctttcctgcgtta


 


tcccctgattctgtggataaccgtattaccgcctttgagtgagctgat


 


accgctcgccgcagccgaacgaccgagcgcagcgagtcagtgagcgag


 


gaagcggaagagcgcctgatgcggtattttctccttacgcatctgtgc


 


ggtatttcacaccgcatatatggtgcactctcagtacaatctgctctg


 


atgccgcatagttaagccagtatacactccgctatcgctacgtgactg


 


ggtcatggctgcgccccgacacccgccaacacccgctgacgcgccctg


 


acgggcttgtctgctcccggcatccgcttacagacaagctgtgaccgt


 


ctccgggagctgcatgtgtcagaggttttcaccgtcatcaccgaaacg


 


cgcgaggcagctgcggtaaagctcatcagcgtggtcgtgaagcgattc


 


acagatgtctgcctgttcatccgcgtccagctcgttgagtttctccag


 


aagcgttaatgtctggcttctgataaagcgggccatgttaagggcggt


 


tttttcctgtttggtcactgatgcctccgtgtaagggggatttctgtt


 


catgggggtaatgataccgatgaaacgagagaggatgctcacgatacg


 


ggttactgatgatgaacatgcccggttactggaacgttgtgagggtaa


 


acaactggcggtatggatgcggcgggaccagagaaaaatcactcaggg


 


tcaatgccagcgcttcgttaatacagatgtaggtgttccacagggtag


 


ccagcagcatcctgcgatgcagatccggaacataatggtgcagggcgc


 


tgacttccgcgtttccagactttacgaaacacggaaaccgaagaccat


 


tcatgttgttgctcaggtcgcagacgttttgcagcagcagtcgcttca


 


cgttcgctcgcgtatcggtgattcattctgctaaccagtaaggcaacc


 


ccgccagcctagccgggtcctcaacgacaggagcacgatcatgcgcac


 


ccgtggggccgccatgccggcgataatggcctgcttctcgccgaaacg


 


tttggtggcgggaccagtgacgaaggcttgagcgagggcgtgcaagat


 


tccgaataccgcaagcgacaggccgatcatcgtcgcgctccagcgaaa


 


gcggtcctcgccgaaaatgacccagagcgctgccggcacctgtcctac


 


gagttgcatgataaagaagacagtcataagtgcggcgacgatagtcat


 


gccccgcgcccaccggaaggagctgactgggttgaaggctctcaaggg


 


catcggtcgagatcccggtgcctaatgagtgagctaacttacattaat


 


tgcgttgcgctcactgcccgctttccagtcgggaaacctgtcgtgcca


 


gctgcattaatgaatcggccaacgcgcggggagaggcggtttgcgtat


 


tgggcgccagggtggtttttcttttcaccagtgagacgggcaacagct


 


gattgcccttcaccgcctggccctgagagagttgcagcaagcggtcca


 


cgctggtttgccccagcaggcgaaaatcctgtttgatggtggttaacg


 


gcgggatataacatgagctgtcttcggtatcgtcgtatcccactaccg


 


agatatccgcaccaacgcgcagcccggactcggtaatggcgcgcattg


 


cgcccagcgccatctgatcgttggcaaccagcatcgcagtgggaacga


 


tgccctcattcagcatttgcatggtttgttgaaaaccggacatggcac


 


tccagtcgccttcccgttccgctatcggctgaatttgattgcgagtga


 


gatatttatgccagccagccagacgcagacgcgccgagacagaactta


 


atgggcccgctaacagcgcgatttgctggtgacccaatgcgaccagat


 


gctccacgcccagtcgcgtaccgtcttcatgggagaaaataatactgt


 


tgatgggtgtctggtcagagacatcaagaaataacgccggaacattag


 


tgcaggcagcttccacagcaatggcatcctggtcatccagcggatagt


 


taatgatcagcccactgacgcgttgcgcgagaagattgtgcaccgccg


 


ctttacaggcttcgacgccgcttcgttctaccatcgacaccaccacgc


 


tggcacccagttgatcggcgcgagatttaatcgccgcgacaatttgcg


 


acggcgcgtgcagggccagactggaggtggcaacgccaatcagcaacg


 


actgtttgcccgccagttgttgtgccacgcggttgggaatgtaattca


 


gctccgccatcgccgcttccactttttcccgcgttttcgcagaaacgt


 


ggctggcctggttcaccacgcgggaaacggtctgataagagacaccgg


 


catactctgcgacatcgtataacgttactggtttcacattcaccaccc


 


tgaattgactctcttccgggcgctatcatgccataccgcgaaaggttt


 


tgcgccattcgatggtgtccgggatctcgacgctctcccttatgcgac


 


tcctgcattaggaagcagcccagtagtaggttgaggccgttgagcacc


 


gccgccgcaaggaatggtgcatgcaaggagatggcgcccaacagtccc


 


ccggccacggggcctgccaccatacccacgccgaaacaagcgctcatg


 


agcccgaagtggcgagcccgatcttccccatcggtgatgtcggcgata


 


taggcgccagcaaccgcacctgtggcgccggtgatgccggccacgatg


 


cgtccggcgtagaggatcgagatctcgatcccgcgaaattaatacgac


 


tcactataggggaattgtgagcggataacaattcccctctagaaataa


 


ttttgtttaactttaagaaggagatatacatatggaagctcgtcgttc


 


tgcgaactacgaacctaacagctgggactatgattacctgctgtcctc


 


cgacacggacgagtccatcgaagtatacaaagacaaagcgaaaaagct


 


ggaagccgaagttcgtcgcgagattaataacgaaaaagcagaatttct


 


gaccctgctggaactgattgacaacgtccagcgcctgggcctgggtta


 


ccgtttcgagtctgatatccgtggtgcgctggatcgcttcgtttcctc


 


cggcggcttcgatgcggtaaccaagacttccctgcacggtacggcact


 


gtctttccgtctgctgcgtcaacacggttttgaggtttctcaggaagc


 


gttcagcggcttcaaagaccaaaacggcaacttcctggagaacctgaa


 


ggaagatatcaaagctatcctgagcctgtacgaggccagcttcctggc


 


tctggaaggcgaaaacatcctggacgaggcgaaggttttcgcaatctc


 


tcatctgaaagaactgtctgaagaaaagatcggtaaagagctggcaga


 


acaggtgaaccatgcactggaactgccactgcatcgccgtactcagcg


 


tctggaagcagtatggtctatcgaggcctaccgtaaaaaggaggacgc


 


gaatcaggttctgctggagctggcaattctggattacaacatgatcca


 


gtctgtataccagcgtgatctgcgtgaaacgtcccgttggtggcgtcg


 


tgtgggtctggcgaccaaactgcactttgctcgtgaccgcctgattga


 


gagcttctactgggccgtgggtgtagcattcgaaccgcaatactccga


 


ctgccgtaactccgtcgcaaaaatgttttctttcgtaaccattatcga


 


cgatatctacgatgtatacggcaccctggacgaactggagctgtttac


 


tgatgcagttgagcgttgggacgtaaacgccatcaacgacctgccgga


 


ttacatgaaactgtgctttctggctctgtataacactattaacgaaat


 


cgcctacgacaacctgaaagataaaggtgagaacatcctgccgtatct


 


gaccaaagcctgggctgacctgtgcaacgctttcctgcaagaagccaa


 


gtggctgtacaacaaatctactccgacctttgacgactacttcggcaa


 


cgcatggaaatcctcttctggcccgctgcaactggtgttcgcttactt


 


cgctgtcgtgcagaacattaaaaaggaagagatcgaaaacctgcaaaa


 


ataccatgacaccatctctcgtccttcccatatcttccgtctgtgcaa


 


tgacctggctagcgcgtctgcggaaattgcgcgtggtgaaaccgcaaa


 


tagcgtttcttgttacatgcgcactaaaggtatctccgaagaactggc


 


taccgaaagcgtgatgaatctgatcgatgaaacctggaaaaagatgaa


 


caaggaaaaactgggtggtagcccgttcgcgaaaccgttcgtggaaac


 


cgcgatcaacctggcacgtcaatctcactgcacttatcataacggcga


 


cgcgcatacctctccggatgagctgacccgcaaacgcgttctgtctgt


 


aatctttgaaccgattctgccgtttgaacgcgaaaacctgtattttca


 


gggcctcgagcaccaccaccaccaccactgagatccggctgctaacaa


 


agcccgaaaggaagctgagttggctgctgccaccgctgagcaataact


 


agcataaccccttggggcctctaaacgggtcttgaggggttttttgct


 


gaaaggaggaactatatccggat






Example 7
Biochemical Analysis of P. alba IspS Variants
As denoted in Example 8, P (L494P), SP (G491S, L494P) and SPC (G491S, L494P, T536C) isoprene synthase amino acid variants were determined to contain increased specific activity compared to WT isoprene synthase with the P variant containing the greatest specific activity (2.0 times greater than WT). The KMs of the P, SP, and SPC isoprene synthase amino acid variants were less than the KM of the WT isoprene synthase. In addition, the kcat of the β isoprene synthase amino acid variant was greater than the WT isoprene synthase. These results indicate that the P, SP and SPC amino acid variants of isoprene synthase may improve the efficiency (isoprene production rate/[Isoprene synthase]) of production of isoprene in vivo leading to an improved process for isoprene production.
Methods
Materials:
Lysis Buffer: Ni wash+0.5 mM PMST, 0.01% Tween-20, 1 mg/ml lysozyme, 0.2 mg/ml DNase
Ni wash buffer: 50 mM NaH2PO4, 300 mM NaCl, 20 mM Imidazole, pH 8.0
Ni elution buffer: 50 mM NaH2PO4, 300 mM NaCl, 500 mM Imidazole, pH 8.0
PD-10 buffer: 50 mM Tris, 0.05 M NaCl, pH 8.0
Expression:
1. Overnight culture grown in 3 mL of LB broth at 30 C with Kan50, Chlor25 
2. Transfer 50 uL of overnight culture into 100 mL of fresh LB with antibiotic
3. Grow at 37 C, 250 RPM for 3.5 hours
4. Induce with 400 uM IPTG at OD600 ̃0.4
5. Reduce temp to 30 C and shake for 4 hours.
6. Transfer cells into 50 mL tubes and spin 25 min at 3800 RPM
7. Decant supernatant and repeat centrifugation step with remaining media
8. Decant supernatant
9. Store pellets at −80 C
Purification:
1. Initial Purification—Resuspend the pellet in 3 ml of fresh lysis buffer. Break cells by passing them through the French Press using the small cylinder. Centrifuge samples for 1 hour at 30,000×G and collect the supernatant. Retain pellet in order to test for presence of insoluble protein. Pre equilibrate 0.5 mL Ni Sepharose 6 Fast Flow resin (Amersham) in a 20 ml disposable column with 10 mL of Ni wash buffer. Add protein to column and shake for 60 min at 4 C to bind protein. Elute protein with 2.5 mL Ni elution buffer.
2. Buffer Exchange—Equilibrate a PD-10 column (GE Healthcare) with 25 mL of PD-10 buffer. Load protein on to column and elute with 3.5 mL of PD-10 buffer.
3. Analyze samples using SDS-PAGE to determine relative purity of pellet (p), supernatant (s), and after both columns (ni).
4. Aliquot protein and store at −80 C.
Specific Activity Measurement—
10 uL of purified enzyme was incubated with 4 mM DMAPP, 50 mM MgCl2 in a buffer containing 50 mM Tris and 50 mM NaCl (pH=8) to a final volume of 100 uL for 15 min. at 30 C in gas tight 2 mL vials. Reactions were terminated with the addition of 100 uL of 250 uM EDTA, pH=8. Samples were analyzed by GC-MS to determine the concentration of isoprene in the headspace of the vials. All specific activity measurements were performed in triplicate.
kcat and KM Determination—
10 uL of purified enzyme was incubated with DMAPP at concentrations ranging from 1.25 to 20 mM DMAPP in a buffer containing 50 mM Tris, 50 mM MgCl2 and 50 mM NaCl (pH=8) to a final volume of 100 uL for 15 min. at 30 C in gas tight 2 mL vials. Reactions were terminated with the addition of 100 uL of 250 mM EDTA, pH=8. Samples were analyzed by GC-MS to determine the concentration of isoprene in the headspace of the vials. Data were analyzed using Kaleidagraph and fit to following equation for uncompetitive substrate inhibition: rate/E=kcat*S/(KM+S*(1+S/Ki)). All kinetic assays were performed in triplicate.
Protein Concentration Determination—
Protein concentration was determined by measuring the absorbance of each protein solution at 280 nm on a Helwlett Pachard 8453 UV-Vis spectrophotometer and converting the absorbance to protein concentration using the extinction coefficient as determined on the Expasy website (Gasteiger E., Hoogland C., Gattiker A., Duvaud S., Wilkins M. R., Appel R. D., Bairoch A.; Protein Identification and Analysis Tools on the ExPASy Server; (In) John M. Walker (ed): The Proteomics Protocols Handbook, Humana Press (2005). pp. 571-607). The protein concentrations of isoprene synthase variants assayed for KM and kcat determination were verified by comparative gel electrophoresis of a dilution series of each protein (FIG. 61).
Results/Discussion:
The specific activity of each protein was determined (FIG. 62 and Table 7-4). The specific activity of the β isoprene synthase amino acid variant was 2-fold greater than the specific activity of the WT isoprene synthase. The specific activities of the SP and SPC variants were greater than the WT isoprene synthase but less than the P isoprene synthase variant. All other isoprene synthases tested in this study displayed equal or decreased activity compared to the WT isoprene synthase.
The rate of conversion of DMAPP to isoprene was analyzed over a range of DMAPP concentrations in order to determine the kcat and KM parameters for WT, P, SP and SPC isoprene synthase amino acid variants (FIG. 63, Table 7-5). The enzymes all exhibited rate profiles consistent with uncompetitive substrate inhibition by DMAPP. The KMs of the P, SP, and SPC isoprene synthase variants were less than the KM of the WT isoprene synthase. In addition, the kcat of the β isoprene synthase variant was greater than the kcat of the WT isoprene synthase (Table 7-5)
The L494 residue was chosen for SEL studies because it is a hydrophobic residue within a surface-exposed loop of P. alba IspS. However, we observed that proline is conserved at this site in an alignment of other terpene synthase enzymes. Other Populus species isoprene synthases, along with IspS from P. Montana (Kudzu), and various other terpene synthase enzymes such as M. spicata limonene synthase, S. officinalis bornyl diphosphate synthase, N. tabacum epi-aristolochene synthase were aligned relative to P. alba IspS using the ClustalW algorithm in AlignX of the Vector NTI software (Invitrogen). FIG. 59 shows that at position 494, many other terpene synthase enzymes have a proline residue, suggesting that proline at that position not only is conserved, but that deviation from the consensus could lead to enzymes that are less efficient. Since position 494 is not near the active site of the enzyme, proline may provide stabilization to that specific loop of IspS and hence secondarily enhance the overall kinetic parameters of IspS.







TABLE 7-4







Specific activity of isoprene synthase amino acid variants. Reactions


contained 4 mM DMAPP, 50 mM NaCl, 50 mM Tris pH = 8.


Reactions were performed at 30° C.












S.A.
Variant S.A./



Variant
(nmol/mg/min)
WT S.A.







P
950 ± 40
2.0



C
430 ± 10
0.9



N
170 ± 30
0.4



PC
490 ± 20
1.0



SP
770 ± 40
1.6



NS
480 ± 40
1.0



NC
420 ± 30
0.9



SPC
630 ± 40
1.3



WT
480 ± 20
1.0



S
480 ± 20
1.0



SC
440 ± 20
0.9



NP
490 ± 20
1.0



NPC
440 ± 20
0.9



NSP
465 ± 2 
1.0



NSC
390 ± 20
0.8



NSPC
502 ± 6 
1.1

















TABLE 7-5







kcat, KM and Ki for WT, P, SP,


and SPC amino acid variants of isoprene


synthase. Kcat, KM and Ki were calculated for


each trial and then averaged. The reported


error is one standard deviation of the three


trials that were performed.












Variant
kcat
KM
KiDMAPP







WT
1.5 ± 0.6
7 ± 4
16 ± 9



P
2.1 ± 0.1
3.6 ± 0.5
13 ± 1



SP
1.2 ± 0.1
4.4 ± 0.3
18 ± 1



SPC
1.5 ± 0.4
3.5 ± 0.8
 25 ± 21










Example 8
Expression and Purification of IspS-L494P
Expression of 6×His-Tagged IspS-L494P
N-terminally 6×His-tagged IspS was expressed and purified from strain DW399. The growth procedure is suitable for histidine tagged enzymes expressed in BL21(λDE3)pLysS cells. 10 ml of overnight culture was prepared for each 1 L of planned growth. The appropriate antibiotics (50 ug/ml kanamycin, 50 ug/ml chloramphenicol) were added to 10 ml of LB medium in a 25 ml flask which was inoculated with 1 colony from a fresh plate of cells or directly from glycerol frozen cell stock. Cultures were grown at 30° C. overnight with shaking at  ̃220 rpm. Day cultures were prepared in 1 liter of LB medium with appropriate antibiotics for each culture. Each 1 L day culture was inoculated with 10 ml of overnight culture and grown at 30-37° C. with shaking at  ̃220 rpm until the OD600 reached  ̃0.4-0.6. Day cultures were then induced with 400 μM IPTG and allowed to continue growing at 30° C. with shaking at 220 rpm for  ̃5-6 hours. Cells were then harvested by centrifugation at 10,000×g for 10 min, 4° C. Following harvest, cells were used directly or stored at −80° C. until ready to process.
Purification of 6×His-Tagged IspS
For purification of histidine tagged enzymes from BL21(λDE3)pLysS cells, cells were gently resuspended in fresh Lysis buffer (Lysis buffer: Ni wash buffer+0.5 mM PMST, 0.01% Tween-20, 1 mg/ml lysozyme, 0.2 mg/ml DNaseI; Ni wash buffer: 50 mM NaH2PO4, 300 mM NaCl, 20 mM Imidazole, pH 8.0). Approximately 40-50 ml of lysis buffer was used per 1 L of cell pellet. Cells were then incubated on ice for approximately 30 min. The cell suspension was then lysed fully by passing 2-3 times through a french pressure cell (large french press cell at 1200 psi/High setting) until lysate appeared clear. A sample of the lysate was saved for activity assay and gel analysis ( ̃100 μl). The lysate was then clarified by centrifuging the lysate at 30,000×g for 30 min, 4° C. in a Sorvall Discovery 90SE ultracentrifuge. The supernatant was removed and retained. A sample of the “clarified lysate” was saved for activity assay and gel analysis ( ̃100 μl).
The clarified lysate was run over HisTrap HP columns (GE healthcare) using a gradient from 0-100% Ni buffer B. Following loading of the lysate on the column, the column was washed with Ni wash buffer (50 mM NaH2PO4, 300 mm NaCl, 20 mM imidazole, ph 8.0). The his-tagged IspS was then eluted from the column using a gradient from 0-100% Ni elution buffer (50 mM NaH2PO4, 300 mM NaCl, 500 mM imidazole, ph 8.0) and fractions containing the his-tagged IspS were collected. The column was then washed with Ni stripping buffer (20 mM NaH2PO4, 0.5 m NaCl, 50 mM EDTA, ph 7.4). Samples were then analyzed by SDS-PAGE gel (4-12% gel NUPAGE, Invitrogen) according to manufacturer's directions. Desired fractions were concentrated on spin filters (Vivaspin-20, Sartoris,) and then desalted over a Hi Prep 26/10 Desalting column (GE healthcare) packed with Sephadex G25 resin. The G-25 buffer consisted of 50 mM HEPES, 50 mM NaCl, and 1 mM DTT, pH 7.4. Fractions were then analyzed and concentrated. The samples were then stored at −80° C.
TEV Cleavage (IspS-L494P from Strains DW399)
Strain DW399 is described in Example 6. Digestion was performed with TurboTEV Protease from Eton Bioscience Inc. One unit of TurboTEV per 10 μg of purified protein was used. The digest was performed at 4° C. overnight. Samples were passed through another Ni column equilibrated in the Ni buffer to remove uncleaved enzyme, tag, TurboTEV protease (which is also tagged), and impurities. The Ni column pass though and washes were analyzed using SDS-PAGE gel (NUPAGE, Invitrogen; FIG. 51) and DMAPP activity assays. Samples containing pure enzyme were pooled and desalted into 50 mM NaCl pH 7.4 buffer containing 1 mM DTT and stored at −80° C.
Crystal Structure Determination
The enzyme expressed from strain DW399 was purified as described and a concentrated protein solution was then prepared for surveying possible crystallization conditions. The enzyme was purified independently and surveyed as described below. All in-house crystallization screens were set up using the hanging drop vapor diffusion method. At a minimum, the protein was surveyed using the following commercial screens: the Crystal Screen from Hampton Research (Aliso Viejo, Calif.) and the JCSG+Suite from Qiagen (Valencia, Calif.).
Initial crystallization screens were setup using the Crystal Screen from Hampton Research and the JCSG+Suite from Qiagen. Crystals of the protein derived from DW399 were observed in numerous conditions; optimization included 200 variations of pH, precipitating agents, concentrations, and inhibitors. From the optimization experiments, ten different crystals derived from strain DW399 were screened in-house for diffraction. A crystal composed of IspS-L494P protein was obtained that diffracted to 3.2 Å in house. The large, rod-shaped crystals belong to the tetragonal space group P43212, and have unit cell dimensions a=155.8, b=155.8, c=143.7. The crystals were grown by mixing 2 μL of protein (10 mg/ml protein) with 2 μL of precipitant solution [0.02 M MgCl2, 0.1 M HEPES pH 7.5, 22% (wt/vol) Polyacrylic acid 5100 Na salt] and equilibrated against 500 μL of precipitant. Prior to flash-freezing the crystal in liquid nitrogen, the crystals were cryoprotected by swishing through 0.02 M MgCl2, 0.1 M HEPES pH 7.5, 22% (wt/vol) Polyacrylic acid 5100 Na salt, and 25% (wt/vol) ethylene glycol.
Data were integrated using Mosflm (Leslie, A. (1998) J. of Appl. Crystallography 30, 1036-1040) and scaled using SCALA (Collaborative Computational Project, N. (1994) Acta Crystallographica Section D 50, 760-763). The data were phased with MOLREP (Vagin, A., and Teplyakov, A. (1997) J. of Appl. Crystallography 30, 1022-1025), using the previously determined structure of IspS from P. alba as the starting model. The crystal contains one dimer in the asymmetric unit with a solvent content of 63%. Data collection and refinement statistics are given in Table 8-1.
Refinement with Refmac5 (Collaborative Computational Project, N. (1994) Acta Crystallographica Section D 50, 760-763) was used with iterative manual rebuilding steps using the visualization program Coot (Emsley, P., and Cowtan, K. (2004) Acta Crystallographica Section D 60, 2126-2132). During refinement, the geometry of the protein was checked using Molprobity (Davis, I. W., et al. (2007) Nucl. Acids Res., 35:W375-W383).
The structure consists of two helical domains, a C-terminal domain containing the active site and N-terminal domain with unknown function. The electron density clearly supports the presence of a proline at position 494 in the enzyme derived from strain DW399 (FIG. 52). Structural alignment of the wild type IspS and IspS-L494P show that the overall fold is unchanged, however the conformation of the loop containing residues 490-497 does vary between the wild type and variant proteins (FIG. 53). Coordinates are provided in Table 8-2.







TABLE 8-1





Data Collection and Refinement Statistics for IspS-L494P


















Data Collection




Space Group
P43212



Cell dimensions



A, b, c (Å)
155.8, 155.8, 143.6



α, β, γ, (°)
90.0, 90.0, 90.0



Resolution (Å)
25.7-3.20



Rmerge
 16.6 (40.5)a



<I/σI>
5.7 (2.1)



Completeness (%)
98.8 (95.1)



Redundancy
3.4 (2.4)



Refinement



Resolution (Å)
25.7-3.20



No. measured reflections
99059



No. Unique reflections
27845



Rwork
23.5



Rfree
28.6



rmsd bonds, (Å)
0.005



rmsd angles, (°)
0.756



No. of Atoms



Protein
8654



Water
4







aValues in parenthesis refer to highest resolution shell.













TABLE 8-2





Coordinates for L494P Structure



























ATOM
1
N
ALA
A
7
58.967
−33.368
−28.452
1.00
32.46
A
N


ATOM
2
CA
ALA
A
7
60.455
−33.320
−28.515
1.00
32.33
A
C


ATOM
4
CB
ALA
A
7
60.968
−34.329
−29.538
1.00
32.27
A
C


ATOM
8
C
ALA
A
7
60.928
−31.913
−28.869
1.00
32.20
A
C


ATOM
9
O
ALA
A
7
61.175
−31.618
−30.038
1.00
31.89
A
O


ATOM
13
N
ASN
A
8
61.056
−31.054
−27.855
1.00
32.28
A
N


ATOM
14
CA
ASN
A
8
61.414
−29.646
−28.067
1.00
32.54
A
C


ATOM
16
CB
ASN
A
8
60.171
−28.754
−27.938
1.00
32.84
A
C


ATOM
19
CG
ASN
A
8
60.193
−27.562
−28.897
1.00
33.76
A
C


ATOM
20
OD1
ASN
A
8
61.242
−26.964
−29.150
1.00
34.16
A
O


ATOM
21
ND2
ASN
A
8
59.027
−27.215
−29.432
1.00
34.29
A
N


ATOM
24
C
ASN
A
8
62.519
−29.158
−27.125
1.00
32.38
A
C


ATOM
25
O
ASN
A
8
62.774
−29.764
−26.081
1.00
31.88
A
O


ATOM
27
N
TYR
A
9
63.148
−28.045
−27.510
1.00
32.53
A
N


ATOM
28
CA
TYR
A
9
64.378
−27.551
−26.881
1.00
32.48
A
C


ATOM
30
CB
TYR
A
9
65.529
−27.650
−27.886
1.00
32.17
A
C


ATOM
33
CG
TYR
A
9
65.491
−28.904
−28.713
1.00
31.92
A
C


ATOM
34
CD1
TYR
A
9
65.999
−30.097
−28.214
1.00
32.88
A
C


ATOM
36
CE1
TYR
A
9
65.963
−31.258
−28.964
1.00
32.64
A
C


ATOM
38
CZ
TYR
A
9
65.409
−31.241
−30.230
1.00
32.19
A
C


ATOM
39
OH
TYR
A
9
65.370
−32.394
−30.978
1.00
31.19
A
O


ATOM
41
CE2
TYR
A
9
64.892
−30.067
−30.748
1.00
31.99
A
C


ATOM
43
CD2
TYR
A
9
64.933
−28.906
−29.987
1.00
31.30
A
C


ATOM
45
C
TYR
A
9
64.297
−26.100
−26.401
1.00
32.65
A
C


ATOM
46
O
TYR
A
9
65.333
−25.490
−26.119
1.00
32.90
A
O


ATOM
48
N
GLU
A
10
63.089
−25.547
−26.304
1.00
32.35
A
N


ATOM
49
CA
GLU
A
10
62.923
−24.126
−25.971
1.00
32.21
A
C


ATOM
51
CB
GLU
A
10
61.450
−23.711
−26.089
1.00
32.51
A
C


ATOM
54
CG
GLU
A
10
60.880
−23.803
−27.509
1.00
34.11
A
C


ATOM
57
CD
GLU
A
10
61.671
−23.001
−28.542
1.00
35.77
A
C


ATOM
58
OE1
GLU
A
10
62.114
−21.874
−28.223
1.00
35.78
A
O


ATOM
59
OE2
GLU
A
10
61.841
−23.503
−29.677
1.00
35.44
A
O


ATOM
60
C
GLU
A
10
63.473
−23.814
−24.572
1.00
31.42
A
C


ATOM
61
O
GLU
A
10
63.467
−24.684
−23.700
1.00
31.43
A
O


ATOM
63
N
PRO
A
11
63.953
−22.572
−24.359
1.00
30.52
A
N


ATOM
64
CA
PRO
A
11
64.709
−22.252
−23.148
1.00
30.13
A
C


ATOM
66
CB
PRO
A
11
65.263
−20.857
−23.449
1.00
30.16
A
C


ATOM
69
CG
PRO
A
11
64.250
−20.247
−24.336
1.00
30.10
A
C


ATOM
72
CD
PRO
A
11
63.722
−21.372
−25.186
1.00
30.45
A
C


ATOM
75
C
PRO
A
11
63.856
−22.208
−21.886
1.00
29.77
A
C


ATOM
76
O
PRO
A
11
62.763
−21.645
−21.902
1.00
30.21
A
O


ATOM
77
N
ASN
A
12
64.357
−22.802
−20.807
1.00
29.24
A
N


ATOM
78
CA
ASN
A
12
63.717
−22.692
−19.501
1.00
28.99
A
C


ATOM
80
CB
ASN
A
12
64.148
−23.841
−18.588
1.00
28.99
A
C


ATOM
83
CG
ASN
A
12
63.744
−25.201
−19.128
1.00
28.62
A
C


ATOM
84
OD1
ASN
A
12
62.558
−25.498
−19.268
1.00
29.36
A
O


ATOM
85
ND2
ASN
A
12
64.731
−26.038
−19.423
1.00
27.55
A
N


ATOM
88
C
ASN
A
12
64.083
−21.348
−18.872
1.00
28.99
A
C


ATOM
89
O
ASN
A
12
65.197
−20.853
−19.062
1.00
29.27
A
O


ATOM
91
N
SER
A
13
63.146
−20.760
−18.131
1.00
28.65
A
N


ATOM
92
CA
SER
A
13
63.365
−19.461
−17.482
1.00
28.22
A
C


ATOM
94
CB
SER
A
13
62.052
−18.933
−16.893
1.00
28.27
A
C


ATOM
97
OG
SER
A
13
61.433
−19.905
−16.067
1.00
27.86
A
O


ATOM
99
C
SER
A
13
64.437
−19.531
−16.388
1.00
27.86
A
C


ATOM
100
O
SER
A
13
65.127
−18.545
−16.117
1.00
27.35
A
O


ATOM
102
N
TRP
A
14
64.573
−20.704
−15.775
1.00
27.59
A
N


ATOM
103
CA
TRP
A
14
65.538
−20.919
−14.697
1.00
27.37
A
C


ATOM
105
CB
TRP
A
14
64.967
−21.893
−13.649
1.00
27.41
A
C


ATOM
108
CG
TRP
A
14
64.246
−23.092
−14.212
1.00
28.21
A
C


ATOM
109
CD1
TRP
A
14
62.894
−23.246
−14.346
1.00
29.22
A
C


ATOM
111
NE1
TRP
A
14
62.607
−24.471
−14.897
1.00
29.08
A
N


ATOM
113
CE2
TRP
A
14
63.781
−25.138
−15.127
1.00
29.46
A
C


ATOM
114
CD2
TRP
A
14
64.836
−24.299
−14.706
1.00
28.64
A
C


ATOM
115
CE3
TRP
A
14
66.153
−24.754
−14.836
1.00
29.12
A
C


ATOM
117
CZ3
TRP
A
14
66.373
−26.014
−15.377
1.00
30.29
A
C


ATOM
119
CH2
TRP
A
14
65.303
−26.825
−15.788
1.00
30.52
A
C


ATOM
121
CZ2
TRP
A
14
64.004
−26.406
−15.670
1.00
30.11
A
C


ATOM
123
C
TRP
A
14
66.912
−21.401
−15.189
1.00
27.25
A
C


ATOM
124
O
TRP
A
14
67.776
−21.723
−14.378
1.00
27.30
A
O


ATOM
126
N
ASP
A
15
67.127
−21.435
−16.503
1.00
27.11
A
N


ATOM
127
CA
ASP
A
15
68.419
−21.859
−17.055
1.00
27.19
A
C


ATOM
129
CB
ASP
A
15
68.371
−21.911
−18.587
1.00
27.21
A
C


ATOM
132
CG
ASP
A
15
67.685
−23.157
−19.117
1.00
27.43
A
C


ATOM
133
OD1
ASP
A
15
67.686
−24.200
−18.426
1.00
26.27
A
O


ATOM
134
OD2
ASP
A
15
67.154
−23.094
−20.246
1.00
29.06
A
O


ATOM
135
C
ASP
A
15
69.562
−20.941
−16.625
1.00
27.45
A
C


ATOM
136
O
ASP
A
15
69.347
−19.773
−16.302
1.00
27.69
A
O


ATOM
138
N
TYR
A
16
70.778
−21.479
−16.633
1.00
27.65
A
N


ATOM
139
CA
TYR
A
16
71.968
−20.698
−16.299
1.00
27.87
A
C


ATOM
141
CB
TYR
A
16
73.122
−21.618
−15.890
1.00
27.97
A
C


ATOM
144
CG
TYR
A
16
72.878
−22.322
−14.569
1.00
28.42
A
C


ATOM
145
CD1
TYR
A
16
72.806
−21.601
−13.378
1.00
28.17
A
C


ATOM
147
CE1
TYR
A
16
72.576
−22.236
−12.164
1.00
26.82
A
C


ATOM
149
CZ
TYR
A
16
72.417
−23.606
−12.130
1.00
26.17
A
C


ATOM
150
OH
TYR
A
16
72.191
−24.230
−10.929
1.00
25.22
A
O


ATOM
152
CE2
TYR
A
16
72.485
−24.348
−13.296
1.00
26.88
A
C


ATOM
154
CD2
TYR
A
16
72.715
−23.704
−14.509
1.00
27.97
A
C


ATOM
156
C
TYR
A
16
72.389
−19.774
−17.445
1.00
28.24
A
C


ATOM
157
O
TYR
A
16
73.125
−18.814
−17.225
1.00
28.23
A
O


ATOM
159
N
ASP
A
17
71.929
−20.071
−18.660
1.00
28.81
A
N


ATOM
160
CA
ASP
A
17
72.109
−19.171
−19.806
1.00
29.05
A
C


ATOM
162
CB
ASP
A
17
71.891
−19.919
−21.129
1.00
28.88
A
C


ATOM
165
CG
ASP
A
17
72.965
−20.962
−21.406
1.00
28.36
A
C


ATOM
166
OD1
ASP
A
17
74.154
−20.593
−21.514
1.00
27.28
A
O


ATOM
167
OD2
ASP
A
17
72.614
−22.154
−21.539
1.00
27.24
A
O


ATOM
168
C
ASP
A
17
71.140
−17.987
−19.726
1.00
29.57
A
C


ATOM
169
O
ASP
A
17
71.501
−16.858
−20.062
1.00
29.32
A
O


ATOM
171
N
TYR
A
18
69.916
−18.260
−19.274
1.00
30.37
A
N


ATOM
172
CA
TYR
A
18
68.828
−17.278
−19.250
1.00
31.29
A
C


ATOM
174
CB
TYR
A
18
67.495
−18.008
−19.056
1.00
31.77
A
C


ATOM
177
CG
TYR
A
18
66.249
−17.171
−19.266
1.00
35.14
A
C


ATOM
178
CD1
TYR
A
18
65.523
−17.255
−20.456
1.00
37.79
A
C


ATOM
180
CE1
TYR
A
18
64.370
−16.503
−20.650
1.00
38.22
A
C


ATOM
182
CZ
TYR
A
18
63.926
−15.661
−19.645
1.00
38.92
A
C


ATOM
183
OH
TYR
A
18
62.785
−14.918
−19.837
1.00
40.58
A
O


ATOM
185
CE2
TYR
A
18
64.623
−15.565
−18.451
1.00
38.20
A
C


ATOM
187
CD2
TYR
A
18
65.775
−16.321
−18.265
1.00
36.98
A
C


ATOM
189
C
TYR
A
18
69.043
−16.237
−18.149
1.00
31.48
A
C


ATOM
190
O
TYR
A
18
69.094
−15.039
−18.426
1.00
31.70
A
O


ATOM
192
N
LEU
A
19
69.156
−16.699
−16.905
1.00
31.72
A
N


ATOM
193
CA
LEU
A
19
69.585
−15.852
−15.792
1.00
31.90
A
C


ATOM
195
CB
LEU
A
19
69.089
−16.416
−14.455
1.00
31.77
A
C


ATOM
198
CG
LEU
A
19
67.574
−16.531
−14.261
1.00
32.74
A
C


ATOM
200
CD1
LEU
A
19
67.248
−17.518
−13.141
1.00
32.00
A
C


ATOM
204
CD2
LEU
A
19
66.943
−15.164
−13.989
1.00
31.72
A
C


ATOM
208
C
LEU
A
19
71.106
−15.825
−15.806
1.00
32.37
A
C


ATOM
209
O
LEU
A
19
71.727
−16.380
−16.712
1.00
32.67
A
O


ATOM
211
N
LEU
A
20
71.709
−15.174
−14.815
1.00
32.83
A
N


ATOM
212
CA
LEU
A
20
73.148
−15.281
−14.594
1.00
33.25
A
C


ATOM
214
CB
LEU
A
20
73.466
−16.668
−14.021
1.00
33.14
A
C


ATOM
217
CG
LEU
A
20
74.826
−16.886
−13.356
1.00
33.70
A
C


ATOM
219
CD1
LEU
A
20
74.988
−15.984
−12.139
1.00
34.63
A
C


ATOM
223
CD2
LEU
A
20
74.985
−18.351
−12.969
1.00
33.93
A
C


ATOM
227
C
LEU
A
20
73.947
−15.025
−15.880
1.00
33.88
A
C


ATOM
228
O
LEU
A
20
74.771
−15.848
−16.292
1.00
33.76
A
O


ATOM
230
N
SER
A
21
73.677
−13.888
−16.519
1.00
34.62
A
N


ATOM
231
CA
SER
A
21
74.409
−13.467
−17.718
1.00
35.00
A
C


ATOM
233
CB
SER
A
21
73.478
−13.378
−18.933
1.00
35.02
A
C


ATOM
236
OG
SER
A
21
73.457
−14.605
−19.644
1.00
34.89
A
O


ATOM
238
C
SER
A
21
75.117
−12.136
−17.488
1.00
35.34
A
C


ATOM
239
O
SER
A
21
74.711
−11.334
−16.639
1.00
34.98
A
O


ATOM
241
N
SER
A
22
76.173
−11.913
−18.266
1.00
35.95
A
N


ATOM
242
CA
SER
A
22
77.087
−10.795
−18.048
1.00
36.40
A
C


ATOM
244
CB
SER
A
22
78.430
−11.076
−18.732
1.00
36.31
A
C


ATOM
247
OG
SER
A
22
78.248
−11.367
−20.107
1.00
35.88
A
O


ATOM
249
C
SER
A
22
76.530
−9.461
−18.543
1.00
36.86
A
C


ATOM
250
O
SER
A
22
76.493
−9.205
−19.751
1.00
36.97
A
O


ATOM
252
N
ASP
A
23
76.099
−8.619
−17.603
1.00
37.22
A
N


ATOM
253
CA
ASP
A
23
75.752
−7.232
−17.906
1.00
37.43
A
C


ATOM
255
CB
ASP
A
23
75.077
−6.567
−16.694
1.00
37.44
A
C


ATOM
258
CG
ASP
A
23
74.428
−5.228
−17.030
1.00
37.60
A
C


ATOM
259
OD1
ASP
A
23
74.332
−4.869
−18.223
1.00
37.88
A
O


ATOM
260
OD2
ASP
A
23
74.003
−4.531
−16.084
1.00
37.64
A
O


ATOM
261
C
ASP
A
23
77.049
−6.517
−18.299
1.00
37.55
A
C


ATOM
262
O
ASP
A
23
77.168
−5.993
−19.410
1.00
37.66
A
O


ATOM
264
N
THR
A
24
78.015
−6.509
−17.380
1.00
37.50
A
N


ATOM
265
CA
THR
A
24
79.413
−6.192
−17.700
1.00
37.32
A
C


ATOM
267
CB
THR
A
24
79.691
−4.665
−17.661
1.00
37.41
A
C


ATOM
269
OG1
THR
A
24
78.608
−3.952
−18.274
1.00
37.33
A
O


ATOM
271
CG2
THR
A
24
80.991
−4.330
−18.392
1.00
36.82
A
C


ATOM
275
C
THR
A
24
80.360
−6.925
−16.730
1.00
37.05
A
C


ATOM
276
O
THR
A
24
81.444
−6.430
−16.407
1.00
37.13
A
O


ATOM
278
N
ASP
A
25
79.944
−8.116
−16.290
1.00
36.41
A
N


ATOM
279
CA
ASP
A
25
80.665
−8.890
−15.278
1.00
35.69
A
C


ATOM
281
CB
ASP
A
25
79.714
−9.307
−14.149
1.00
35.42
A
C


ATOM
284
CG
ASP
A
25
79.022
−8.123
−13.489
1.00
34.28
A
C


ATOM
285
OD1
ASP
A
25
79.536
−6.988
−13.575
1.00
31.33
A
O


ATOM
286
OD2
ASP
A
25
77.956
−8.335
−12.875
1.00
33.31
A
O


ATOM
287
C
ASP
A
25
81.298
−10.136
−15.899
1.00
35.33
A
C


ATOM
288
O
ASP
A
25
80.594
−11.077
−16.273
1.00
35.35
A
O


ATOM
290
N
GLU
A
26
82.625
−10.134
−16.002
1.00
34.79
A
N


ATOM
291
CA
GLU
A
26
83.372
−11.273
−16.546
1.00
34.55
A
C


ATOM
293
CB
GLU
A
26
84.858
−10.920
−16.690
1.00
34.43
A
C


ATOM
296
CG
GLU
A
26
85.159
−9.814
−17.695
1.00
33.53
A
C


ATOM
299
CD
GLU
A
26
86.645
−9.516
−17.821
1.00
31.34
A
C


ATOM
300
OE1
GLU
A
26
87.432
−9.968
−16.962
1.00
30.11
A
O


ATOM
301
OE2
GLU
A
26
87.026
−8.822
−18.785
1.00
29.48
A
O


ATOM
302
C
GLU
A
26
83.251
−12.515
−15.662
1.00
34.62
A
C


ATOM
303
O
GLU
A
26
83.213
−13.644
−16.159
1.00
34.51
A
O


ATOM
305
N
SER
A
27
83.197
−12.292
−14.351
1.00
34.63
A
N


ATOM
306
CA
SER
A
27
83.188
−13.374
−13.365
1.00
34.68
A
C


ATOM
308
CB
SER
A
27
83.367
−12.794
−11.957
1.00
34.79
A
C


ATOM
311
OG
SER
A
27
82.483
−11.706
−11.735
1.00
34.93
A
O


ATOM
313
C
SER
A
27
81.930
−14.252
−13.416
1.00
34.53
A
C


ATOM
314
O
SER
A
27
81.963
−15.407
−12.979
1.00
34.27
A
O


ATOM
316
N
ILE
A
28
80.831
−13.709
−13.942
1.00
34.31
A
N


ATOM
317
CA
ILE
A
28
79.602
−14.484
−14.119
1.00
34.09
A
C


ATOM
319
CB
ILE
A
28
78.412
−13.598
−14.561
1.00
34.14
A
C


ATOM
321
CG1
ILE
A
28
78.065
−12.575
−13.476
1.00
34.77
A
C


ATOM
324
CD1
ILE
A
28
76.877
−11.689
−13.824
1.00
35.54
A
C


ATOM
328
CG2
ILE
A
28
77.190
−14.457
−14.860
1.00
33.66
A
C


ATOM
332
C
ILE
A
28
79.798
−15.599
−15.148
1.00
33.79
A
C


ATOM
333
O
ILE
A
28
79.289
−16.700
−14.968
1.00
33.59
A
O


ATOM
335
N
GLU
A
29
80.552
−15.315
−16.210
1.00
33.59
A
N


ATOM
336
CA
GLU
A
29
80.739
−16.270
−17.313
1.00
33.41
A
C


ATOM
338
CB
GLU
A
29
81.273
−15.556
−18.564
1.00
33.57
A
C


ATOM
341
CG
GLU
A
29
80.268
−14.599
−19.206
1.00
34.79
A
C


ATOM
344
CD
GLU
A
29
78.994
−15.293
−19.675
1.00
35.14
A
C


ATOM
345
OE1
GLU
A
29
79.092
−16.335
−20.357
1.00
35.06
A
O


ATOM
346
OE2
GLU
A
29
77.892
−14.792
−19.362
1.00
35.70
A
O


ATOM
347
C
GLU
A
29
81.627
−17.476
−16.984
1.00
32.74
A
C


ATOM
348
O
GLU
A
29
81.700
−18.415
−17.776
1.00
32.85
A
O


ATOM
350
N
VAL
A
30
82.309
−17.449
−15.840
1.00
31.82
A
N


ATOM
351
CA
VAL
A
30
82.990
−18.640
−15.320
1.00
30.90
A
C


ATOM
353
CB
VAL
A
30
84.379
−18.305
−14.736
1.00
30.95
A
C


ATOM
355
CG1
VAL
A
30
85.158
−19.583
−14.445
1.00
30.39
A
C


ATOM
359
CG2
VAL
A
30
85.160
−17.412
−15.693
1.00
30.85
A
C


ATOM
363
C
VAL
A
30
82.117
−19.310
−14.253
1.00
29.93
A
C


ATOM
364
O
VAL
A
30
82.088
−20.533
−14.149
1.00
29.30
A
O


ATOM
366
N
TYR
A
31
81.419
−18.492
−13.468
1.00
29.33
A
N


ATOM
367
CA
TYR
A
31
80.412
−18.952
−12.504
1.00
28.99
A
C


ATOM
369
CB
TYR
A
31
79.844
−17.729
−11.762
1.00
29.11
A
C


ATOM
372
CG
TYR
A
31
78.990
−18.015
−10.541
1.00
29.97
A
C


ATOM
373
CD1
TYR
A
31
79.552
−18.524
−9.371
1.00
30.42
A
C


ATOM
375
CE1
TYR
A
31
78.767
−18.768
−8.241
1.00
31.07
A
C


ATOM
377
CZ
TYR
A
31
77.406
−18.490
−8.274
1.00
31.23
A
C


ATOM
378
OH
TYR
A
31
76.621
−18.728
−7.165
1.00
30.48
A
O


ATOM
380
CE2
TYR
A
31
76.829
−17.972
−9.420
1.00
30.59
A
C


ATOM
382
CD2
TYR
A
31
77.623
−17.731
−10.542
1.00
31.01
A
C


ATOM
384
C
TYR
A
31
79.294
−19.726
−13.225
1.00
28.35
A
C


ATOM
385
O
TYR
A
31
78.896
−20.815
−12.802
1.00
28.24
A
O


ATOM
387
N
LYS
A
32
78.811
−19.143
−14.321
1.00
27.54
A
N


ATOM
388
CA
LYS
A
32
77.792
−19.738
−15.196
1.00
26.68
A
C


ATOM
390
CB
LYS
A
32
77.434
−18.724
−16.292
1.00
27.16
A
C


ATOM
393
CG
LYS
A
32
76.586
−19.211
−17.469
1.00
27.92
A
C


ATOM
396
CD
LYS
A
32
76.980
−18.446
−18.748
1.00
29.61
A
C


ATOM
399
CE
LYS
A
32
75.811
−18.227
−19.693
1.00
30.33
A
C


ATOM
402
NZ
LYS
A
32
74.948
−17.083
−19.266
1.00
30.04
A
N


ATOM
406
C
LYS
A
32
78.285
−21.036
−15.826
1.00
25.58
A
C


ATOM
407
O
LYS
A
32
77.620
−22.067
−15.728
1.00
25.63
A
O


ATOM
409
N
ASP
A
33
79.448
−20.974
−16.475
1.00
24.33
A
N


ATOM
410
CA
ASP
A
33
80.056
−22.154
−17.106
1.00
23.26
A
C


ATOM
412
CB
ASP
A
33
81.367
−21.783
−17.822
1.00
23.36
A
C


ATOM
415
CG
ASP
A
33
81.142
−21.100
−19.173
1.00
23.27
A
C


ATOM
416
OD1
ASP
A
33
79.992
−21.051
−19.659
1.00
23.99
A
O


ATOM
417
OD2
ASP
A
33
82.133
−20.612
−19.757
1.00
21.23
A
O


ATOM
418
C
ASP
A
33
80.313
−23.278
−16.099
1.00
22.17
A
C


ATOM
419
O
ASP
A
33
80.256
−24.455
−16.454
1.00
21.98
A
O


ATOM
421
N
LYS
A
34
80.592
−22.910
−14.849
1.00
21.18
A
N


ATOM
422
CA
LYS
A
34
80.789
−23.885
−13.774
1.00
20.15
A
C


ATOM
424
CB
LYS
A
34
81.420
−23.221
−12.541
1.00
19.97
A
C


ATOM
427
CG
LYS
A
34
82.264
−24.155
−11.679
1.00
19.67
A
C


ATOM
430
CD
LYS
A
34
83.466
−23.426
−11.061
1.00
20.43
A
C


ATOM
433
CE
LYS
A
34
84.646
−24.371
−10.818
1.00
20.70
A
C


ATOM
436
NZ
LYS
A
34
85.942
−23.644
−10.709
1.00
17.82
A
N


ATOM
440
C
LYS
A
34
79.457
−24.534
−13.409
1.00
19.43
A
C


ATOM
441
O
LYS
A
34
79.368
−25.759
−13.320
1.00
20.13
A
O


ATOM
443
N
ALA
A
35
78.427
−23.712
−13.209
1.00
17.92
A
N


ATOM
444
CA
ALA
A
35
77.080
−24.211
−12.927
1.00
16.84
A
C


ATOM
446
CB
ALA
A
35
76.086
−23.063
−12.871
1.00
16.71
A
C


ATOM
450
C
ALA
A
35
76.656
−25.222
−13.984
1.00
16.12
A
C


ATOM
451
O
ALA
A
35
76.317
−26.360
−13.663
1.00
15.55
A
O


ATOM
453
N
LYS
A
36
76.703
−24.798
−15.245
1.00
15.82
A
N


ATOM
454
CA
LYS
A
36
76.337
−25.647
−16.385
1.00
15.48
A
C


ATOM
456
CB
LYS
A
36
76.637
−24.921
−17.708
1.00
15.46
A
C


ATOM
459
CG
LYS
A
36
75.690
−23.752
−18.007
1.00
14.99
A
C


ATOM
462
CD
LYS
A
36
76.314
−22.686
−18.917
1.00
13.95
A
C


ATOM
465
CE
LYS
A
36
76.428
−23.143
−20.367
1.00
13.77
A
C


ATOM
468
NZ
LYS
A
36
76.844
−22.031
−21.277
1.00
12.18
A
N


ATOM
472
C
LYS
A
36
77.038
−27.011
−16.359
1.00
15.21
A
C


ATOM
473
O
LYS
A
36
76.413
−28.030
−16.650
1.00
15.02
A
O


ATOM
475
N
LYS
A
37
78.324
−27.024
−16.004
1.00
15.15
A
N


ATOM
476
CA
LYS
A
37
79.104
−28.267
−15.941
1.00
15.11
A
C


ATOM
478
CB
LYS
A
37
80.602
−27.970
−15.781
1.00
15.02
A
C


ATOM
481
CG
LYS
A
37
81.457
−29.221
−15.544
1.00
16.38
A
C


ATOM
484
CD
LYS
A
37
82.922
−29.033
−15.934
1.00
16.66
A
C


ATOM
487
CE
LYS
A
37
83.714
−30.321
−15.703
1.00
15.63
A
C


ATOM
490
NZ
LYS
A
37
85.058
−30.304
−16.342
1.00
14.75
A
N


ATOM
494
C
LYS
A
37
78.626
−29.187
−14.813
1.00
15.19
A
C


ATOM
495
O
LYS
A
37
78.467
−30.397
−15.011
1.00
15.35
A
O


ATOM
497
N
LEU
A
38
78.405
−28.612
−13.633
1.00
14.82
A
N


ATOM
498
CA
LEU
A
38
77.904
−29.372
−12.488
1.00
14.29
A
C


ATOM
500
CB
LEU
A
38
77.978
−28.533
−11.208
1.00
14.07
A
C


ATOM
503
CG
LEU
A
38
79.356
−28.035
−10.767
1.00
13.08
A
C


ATOM
505
CD1
LEU
A
38
79.227
−27.212
−9.494
1.00
10.42
A
C


ATOM
509
CD2
LEU
A
38
80.325
−29.193
−10.568
1.00
12.91
A
C


ATOM
513
C
LEU
A
38
76.463
−29.837
−12.717
1.00
14.27
A
C


ATOM
514
O
LEU
A
38
76.094
−30.948
−12.336
1.00
14.74
A
O


ATOM
516
N
GLU
A
39
75.656
−28.979
−13.339
1.00
13.96
A
N


ATOM
517
CA
GLU
A
39
74.263
−29.296
−13.651
1.00
13.65
A
C


ATOM
519
CB
GLU
A
39
73.599
−28.108
−14.354
1.00
13.97
A
C


ATOM
522
CG
GLU
A
39
72.085
−28.233
−14.528
1.00
14.95
A
C


ATOM
525
CD
GLU
A
39
71.485
−27.097
−15.345
1.00
16.13
A
C


ATOM
526
OE1
GLU
A
39
72.200
−26.522
−16.200
1.00
15.33
A
O


ATOM
527
OE2
GLU
A
39
70.291
−26.787
−15.136
1.00
15.50
A
O


ATOM
528
C
GLU
A
39
74.160
−30.536
−14.534
1.00
13.24
A
C


ATOM
529
O
GLU
A
39
73.290
−31.379
−14.327
1.00
13.19
A
O


ATOM
531
N
ALA
A
40
75.050
−30.635
−15.517
1.00
13.18
A
N


ATOM
532
CA
ALA
A
40
75.078
−31.773
−16.434
1.00
13.27
A
C


ATOM
534
CB
ALA
A
40
76.121
−31.545
−17.518
1.00
13.09
A
C


ATOM
538
C
ALA
A
40
75.372
−33.075
−15.694
1.00
13.60
A
C


ATOM
539
O
ALA
A
40
74.631
−34.052
−15.815
1.00
13.20
A
O


ATOM
541
N
GLU
A
41
76.459
−33.071
−14.926
1.00
14.01
A
N


ATOM
542
CA
GLU
A
41
76.892
−34.243
−14.162
1.00
13.91
A
C


ATOM
544
CB
GLU
A
41
78.136
−33.902
−13.331
1.00
14.03
A
C


ATOM
547
CG
GLU
A
41
78.963
−35.108
−12.883
1.00
14.30
A
C


ATOM
550
CD
GLU
A
41
80.385
−34.740
−12.450
1.00
14.59
A
C


ATOM
551
OE1
GLU
A
41
80.750
−33.545
−12.486
1.00
13.71
A
O


ATOM
552
OE2
GLU
A
41
81.147
−35.655
−12.077
1.00
16.03
A
O


ATOM
553
C
GLU
A
41
75.766
−34.772
−13.268
1.00
13.65
A
C


ATOM
554
O
GLU
A
41
75.536
−35.976
−13.210
1.00
13.97
A
O


ATOM
556
N
VAL
A
42
75.058
−33.872
−12.592
1.00
13.32
A
N


ATOM
557
CA
VAL
A
42
73.908
−34.261
−11.772
1.00
13.82
A
C


ATOM
559
CB
VAL
A
42
73.337
−33.065
−10.980
1.00
13.98
A
C


ATOM
561
CG1
VAL
A
42
72.097
−33.481
−10.190
1.00
11.81
A
C


ATOM
565
CG2
VAL
A
42
74.399
−32.489
−10.054
1.00
14.38
A
C


ATOM
569
C
VAL
A
42
72.795
−34.852
−12.638
1.00
14.41
A
C


ATOM
570
O
VAL
A
42
72.145
−35.826
−12.252
1.00
14.02
A
O


ATOM
572
N
ARG
A
43
72.581
−34.250
−13.806
1.00
15.17
A
N


ATOM
573
CA
ARG
A
43
71.602
−34.748
−14.771
1.00
15.29
A
C


ATOM
575
CB
ARG
A
43
71.509
−33.805
−15.980
1.00
15.11
A
C


ATOM
578
CG
ARG
A
43
70.642
−34.310
−17.123
1.00
15.92
A
C


ATOM
581
CD
ARG
A
43
71.411
−35.191
−18.114
1.00
15.67
A
C


ATOM
584
NE
ARG
A
43
70.592
−35.551
−19.270
1.00
16.12
A
N


ATOM
586
CZ
ARG
A
43
70.913
−36.472
−20.177
1.00
16.78
A
C


ATOM
587
NH1
ARG
A
43
70.082
−36.721
−21.183
1.00
17.28
A
N


ATOM
590
NH2
ARG
A
43
72.053
−37.151
−20.093
1.00
17.42
A
N


ATOM
593
C
ARG
A
43
71.965
−36.162
−15.216
1.00
15.15
A
C


ATOM
594
O
ARG
A
43
71.100
−37.037
−15.276
1.00
15.51
A
O


ATOM
596
N
ARG
A
44
73.241
−36.374
−15.531
1.00
14.58
A
N


ATOM
597
CA
ARG
A
44
73.725
−37.680
−15.973
1.00
14.27
A
C


ATOM
599
CB
ARG
A
44
75.239
−37.638
−16.204
1.00
14.13
A
C


ATOM
602
CG
ARG
A
44
75.837
−38.956
−16.685
1.00
13.74
A
C


ATOM
605
CD
ARG
A
44
77.311
−38.822
−17.038
1.00
12.58
A
C


ATOM
608
NE
ARG
A
44
78.167
−38.729
−15.858
1.00
10.73
A
N


ATOM
610
CZ
ARG
A
44
79.495
−38.644
−15.897
1.00
10.52
A
C


ATOM
611
NH1
ARG
A
44
80.187
−38.566
−14.766
1.00
10.42
A
N


ATOM
614
NH2
ARG
A
44
80.139
−38.638
−17.061
1.00
11.08
A
N


ATOM
617
C
ARG
A
44
73.391
−38.772
−14.963
1.00
14.55
A
C


ATOM
618
O
ARG
A
44
72.868
−39.825
−15.327
1.00
14.69
A
O


ATOM
620
N
GLU
A
45
73.690
−38.506
−13.694
1.00
14.88
A
N


ATOM
621
CA
GLU
A
45
73.533
−39.502
−12.633
1.00
15.12
A
C


ATOM
623
CB
GLU
A
45
74.228
−39.032
−11.351
1.00
15.38
A
C


ATOM
626
CG
GLU
A
45
75.737
−38.939
−11.473
1.00
15.34
A
C


ATOM
629
CD
GLU
A
45
76.367
−40.280
−11.758
1.00
15.55
A
C


ATOM
630
OE1
GLU
A
45
76.236
−41.183
−10.906
1.00
16.23
A
O


ATOM
631
OE2
GLU
A
45
76.982
−40.433
−12.835
1.00
15.50
A
O


ATOM
632
C
GLU
A
45
72.074
−39.843
−12.337
1.00
15.09
A
C


ATOM
633
O
GLU
A
45
71.771
−40.973
−11.951
1.00
15.45
A
O


ATOM
635
N
ILE
A
46
71.180
−38.870
−12.506
1.00
14.76
A
N


ATOM
636
CA
ILE
A
46
69.744
−39.112
−12.348
1.00
14.30
A
C


ATOM
638
CB
ILE
A
46
68.926
−37.795
−12.366
1.00
14.11
A
C


ATOM
640
CG1
ILE
A
46
69.239
−36.947
−11.130
1.00
13.91
A
C


ATOM
643
CD1
ILE
A
46
68.714
−35.524
−11.210
1.00
11.51
A
C


ATOM
647
CG2
ILE
A
46
67.439
−38.092
−12.399
1.00
13.21
A
C


ATOM
651
C
ILE
A
46
69.232
−40.051
−13.446
1.00
14.04
A
C


ATOM
652
O
ILE
A
46
68.418
−40.939
−13.175
1.00
13.88
A
O


ATOM
654
N
ASN
A
47
69.725
−39.856
−14.671
1.00
13.76
A
N


ATOM
655
CA
ASN
A
47
69.287
−40.643
−15.834
1.00
13.67
A
C


ATOM
657
CB
ASN
A
47
69.461
−39.835
−17.124
1.00
13.22
A
C


ATOM
660
CG
ASN
A
47
68.546
−38.636
−17.190
1.00
12.47
A
C


ATOM
661
OD1
ASN
A
47
67.387
−38.694
−16.774
1.00
12.16
A
O


ATOM
662
ND2
ASN
A
47
69.058
−37.539
−17.722
1.00
13.14
A
N


ATOM
665
C
ASN
A
47
69.994
−41.987
−15.994
1.00
13.91
A
C


ATOM
666
O
ASN
A
47
69.587
−42.808
−16.817
1.00
13.86
A
O


ATOM
668
N
ASN
A
48
71.048
−42.205
−15.213
1.00
14.42
A
N


ATOM
669
CA
ASN
A
48
71.827
−43.441
−15.274
1.00
14.74
A
C


ATOM
671
CB
ASN
A
48
72.850
−43.469
−14.132
1.00
14.72
A
C


ATOM
674
CG
ASN
A
48
73.753
−44.679
−14.183
1.00
13.04
A
C


ATOM
675
OD1
ASN
A
48
74.135
−45.138
−15.256
1.00
11.75
A
O


ATOM
676
ND2
ASN
A
48
74.106
−45.199
−13.017
1.00
13.70
A
N


ATOM
679
C
ASN
A
48
70.947
−44.693
−15.222
1.00
15.25
A
C


ATOM
680
O
ASN
A
48
70.371
−45.016
−14.186
1.00
14.91
A
O


ATOM
682
N
GLU
A
49
70.855
−45.385
−16.355
1.00
16.44
A
N


ATOM
683
CA
GLU
A
49
70.070
−46.615
−16.472
1.00
17.44
A
C


ATOM
685
CB
GLU
A
49
70.073
−47.113
−17.924
1.00
17.86
A
C


ATOM
688
CG
GLU
A
49
69.434
−46.153
−18.947
1.00
20.47
A
C


ATOM
691
CD
GLU
A
49
67.909
−46.256
−19.022
1.00
23.90
A
C


ATOM
692
OE1
GLU
A
49
67.362
−47.364
−18.830
1.00
26.25
A
O


ATOM
693
OE2
GLU
A
49
67.256
−45.223
−19.293
1.00
24.41
A
O


ATOM
694
C
GLU
A
49
70.608
−47.715
−15.555
1.00
17.76
A
C


ATOM
695
O
GLU
A
49
69.839
−48.490
−14.995
1.00
17.28
A
O


ATOM
697
N
LYS
A
50
71.929
−47.765
−15.402
1.00
18.95
A
N


ATOM
698
CA
LYS
A
50
72.596
−48.784
−14.591
1.00
19.93
A
C


ATOM
700
CB
LYS
A
50
73.871
−49.267
−15.298
1.00
20.28
A
C


ATOM
703
CG
LYS
A
50
73.695
−49.676
−16.758
1.00
21.77
A
C


ATOM
706
CD
LYS
A
50
74.932
−50.420
−17.276
1.00
23.08
A
C


ATOM
709
CE
LYS
A
50
75.158
−50.200
−18.772
1.00
23.59
A
C


ATOM
712
NZ
LYS
A
50
73.974
−50.577
−19.593
1.00
23.30
A
N


ATOM
716
C
LYS
A
50
72.955
−48.250
−13.200
1.00
20.51
A
C


ATOM
717
O
LYS
A
50
74.120
−48.286
−12.796
1.00
20.59
A
O


ATOM
719
N
ALA
A
51
71.958
−47.758
−12.470
1.00
21.42
A
N


ATOM
720
CA
ALA
A
51
72.171
−47.241
−11.116
1.00
22.31
A
C


ATOM
722
CB
ALA
A
51
71.607
−45.839
−10.994
1.00
22.41
A
C


ATOM
726
C
ALA
A
51
71.525
−48.163
−10.085
1.00
23.21
A
C


ATOM
727
O
ALA
A
51
70.500
−48.791
−10.361
1.00
23.63
A
O


ATOM
729
N
GLU
A
52
72.124
−48.239
−8.898
1.00
23.78
A
N


ATOM
730
CA
GLU
A
52
71.577
−49.056
−7.816
1.00
24.30
A
C


ATOM
732
CB
GLU
A
52
72.590
−49.208
−6.675
1.00
24.41
A
C


ATOM
735
CG
GLU
A
52
72.493
−50.535
−5.927
1.00
26.16
A
C


ATOM
738
CD
GLU
A
52
72.854
−51.746
−6.787
1.00
27.22
A
C


ATOM
739
OE1
GLU
A
52
73.411
−51.571
−7.894
1.00
27.13
A
O


ATOM
740
OE2
GLU
A
52
72.580
−52.881
−6.345
1.00
28.02
A
O


ATOM
741
C
GLU
A
52
70.296
−48.394
−7.320
1.00
24.56
A
C


ATOM
742
O
GLU
A
52
70.241
−47.171
−7.194
1.00
25.07
A
O


ATOM
744
N
PHE
A
53
69.272
−49.199
−7.049
1.00
24.66
A
N


ATOM
745
CA
PHE
A
53
67.932
−48.672
−6.762
1.00
24.68
A
C


ATOM
747
CB
PHE
A
53
66.919
−49.811
−6.571
1.00
25.20
A
C


ATOM
750
CG
PHE
A
53
66.487
−50.467
−7.862
1.00
28.10
A
C


ATOM
751
CD1
PHE
A
53
65.998
−49.700
−8.920
1.00
30.01
A
C


ATOM
753
CE1
PHE
A
53
65.592
−50.296
−10.112
1.00
30.91
A
C


ATOM
755
CZ
PHE
A
53
65.666
−51.679
−10.254
1.00
32.14
A
C


ATOM
757
CE2
PHE
A
53
66.144
−52.458
−9.202
1.00
31.02
A
C


ATOM
759
CD2
PHE
A
53
66.549
−51.851
−8.013
1.00
29.73
A
C


ATOM
761
C
PHE
A
53
67.879
−47.717
−5.566
1.00
23.76
A
C


ATOM
762
O
PHE
A
53
67.250
−46.663
−5.650
1.00
23.93
A
O


ATOM
764
N
LEU
A
54
68.535
−48.075
−4.465
1.00
22.52
A
N


ATOM
765
CA
LEU
A
54
68.557
−47.206
−3.286
1.00
21.36
A
C


ATOM
767
CB
LEU
A
54
69.083
−47.951
−2.055
1.00
21.51
A
C


ATOM
770
CG
LEU
A
54
68.781
−47.281
−0.708
1.00
21.41
A
C


ATOM
772
CD1
LEU
A
54
67.301
−47.429
−0.372
1.00
20.97
A
C


ATOM
776
CD2
LEU
A
54
69.653
−47.855
0.412
1.00
19.73
A
C


ATOM
780
C
LEU
A
54
69.401
−45.959
−3.541
1.00
20.27
A
C


ATOM
781
O
LEU
A
54
69.000
−44.856
−3.175
1.00
20.35
A
O


ATOM
783
N
THR
A
55
70.561
−46.142
−4.170
1.00
19.14
A
N


ATOM
784
CA
THR
A
55
71.463
−45.031
−4.495
1.00
18.11
A
C


ATOM
786
CB
THR
A
55
72.739
−45.521
−5.210
1.00
18.12
A
C


ATOM
788
OG1
THR
A
55
73.383
−46.521
−4.412
1.00
17.71
A
O


ATOM
790
CG2
THR
A
55
73.707
−44.363
−5.451
1.00
17.05
A
C


ATOM
794
C
THR
A
55
70.787
−43.994
−5.380
1.00
17.32
A
C


ATOM
795
O
THR
A
55
71.003
−42.798
−5.210
1.00
17.16
A
O


ATOM
797
N
LEU
A
56
69.975
−44.457
−6.327
1.00
16.99
A
N


ATOM
798
CA
LEU
A
56
69.204
−43.555
−7.179
1.00
17.23
A
C


ATOM
800
CB
LEU
A
56
68.488
−44.324
−8.295
1.00
17.55
A
C


ATOM
803
CG
LEU
A
56
67.539
−43.518
−9.196
1.00
18.41
A
C


ATOM
805
CD1
LEU
A
56
68.246
−42.308
−9.796
1.00
18.81
A
C


ATOM
809
CD2
LEU
A
56
66.954
−44.398
−10.296
1.00
19.59
A
C


ATOM
813
C
LEU
A
56
68.190
−42.785
−6.343
1.00
16.79
A
C


ATOM
814
O
LEU
A
56
68.100
−41.559
−6.443
1.00
16.92
A
O


ATOM
816
N
LEU
A
57
67.436
−43.511
−5.520
1.00
16.16
A
N


ATOM
817
CA
LEU
A
57
66.437
−42.899
−4.643
1.00
15.66
A
C


ATOM
819
CB
LEU
A
57
65.700
−43.972
−3.833
1.00
15.19
A
C


ATOM
822
CG
LEU
A
57
64.765
−44.889
−4.625
1.00
14.21
A
C


ATOM
824
CD1
LEU
A
57
64.334
−46.067
−3.767
1.00
13.60
A
C


ATOM
828
CD2
LEU
A
57
63.552
−44.133
−5.151
1.00
11.60
A
C


ATOM
832
C
LEU
A
57
67.055
−41.859
−3.701
1.00
15.52
A
C


ATOM
833
O
LEU
A
57
66.458
−40.809
−3.453
1.00
15.41
A
O


ATOM
835
N
GLU
A
58
68.254
−42.147
−3.197
1.00
15.21
A
N


ATOM
836
CA
GLU
A
58
68.940
−41.238
−2.274
1.00
14.75
A
C


ATOM
838
CB
GLU
A
58
69.981
−41.988
−1.430
1.00
14.86
A
C


ATOM
841
CG
GLU
A
58
69.363
−42.871
−0.341
1.00
15.06
A
C


ATOM
844
CD
GLU
A
58
70.385
−43.442
0.633
1.00
16.98
A
C


ATOM
845
OE1
GLU
A
58
71.547
−42.981
0.644
1.00
19.17
A
O


ATOM
846
OE2
GLU
A
58
70.020
−44.360
1.398
1.00
18.53
A
O


ATOM
847
C
GLU
A
58
69.575
−40.035
−2.975
1.00
14.11
A
C


ATOM
848
O
GLU
A
58
69.657
−38.959
−2.382
1.00
14.43
A
O


ATOM
850
N
LEU
A
59
70.020
−40.202
−4.221
1.00
13.22
A
N


ATOM
851
CA
LEU
A
59
70.528
−39.065
−4.999
1.00
12.44
A
C


ATOM
853
CB
LEU
A
59
71.180
−39.518
−6.311
1.00
12.19
A
C


ATOM
856
CG
LEU
A
59
71.677
−38.393
−7.235
1.00
10.80
A
C


ATOM
858
CD1
LEU
A
59
72.780
−37.589
−6.572
1.00
9.85
A
C


ATOM
862
CD2
LEU
A
59
72.154
−38.949
−8.566
1.00
9.48
A
C


ATOM
866
C
LEU
A
59
69.390
−38.100
−5.298
1.00
12.08
A
C


ATOM
867
O
LEU
A
59
69.549
−36.889
−5.164
1.00
11.53
A
O


ATOM
869
N
ILE
A
60
68.249
−38.649
−5.706
1.00
12.13
A
N


ATOM
870
CA
ILE
A
60
67.048
−37.856
−5.955
1.00
12.54
A
C


ATOM
872
CB
ILE
A
60
65.863
−38.745
−6.386
1.00
12.58
A
C


ATOM
874
CG1
ILE
A
60
66.077
−39.276
−7.806
1.00
12.32
A
C


ATOM
877
CD1
ILE
A
60
65.083
−40.350
−8.213
1.00
9.20
A
C


ATOM
881
CG2
ILE
A
60
64.557
−37.964
−6.324
1.00
13.18
A
C


ATOM
885
C
ILE
A
60
66.649
−37.073
−4.707
1.00
13.10
A
C


ATOM
886
O
ILE
A
60
66.474
−35.853
−4.761
1.00
13.34
A
O


ATOM
888
N
ASP
A
61
66.512
−37.782
−3.587
1.00
13.39
A
N


ATOM
889
CA
ASP
A
61
66.154
−37.162
−2.310
1.00
13.31
A
C


ATOM
891
CB
ASP
A
61
66.150
−38.205
−1.185
1.00
13.34
A
C


ATOM
894
CG
ASP
A
61
65.640
−37.650
0.139
1.00
13.56
A
C


ATOM
895
OD1
ASP
A
61
64.927
−36.625
0.136
1.00
12.03
A
O


ATOM
896
OD2
ASP
A
61
65.946
−38.252
1.191
1.00
15.02
A
O


ATOM
897
C
ASP
A
61
67.121
−36.027
−1.979
1.00
13.29
A
C


ATOM
898
O
ASP
A
61
66.694
−34.889
−1.777
1.00
13.14
A
O


ATOM
900
N
ASN
A
62
68.416
−36.345
−1.943
1.00
13.31
A
N


ATOM
901
CA
ASN
A
62
69.463
−35.346
−1.704
1.00
13.68
A
C


ATOM
903
CB
ASN
A
62
70.865
−35.972
−1.816
1.00
13.84
A
C


ATOM
906
CG
ASN
A
62
71.306
−36.690
−0.542
1.00
13.75
A
C


ATOM
907
OD1
ASN
A
62
70.678
−36.574
0.510
1.00
11.26
A
O


ATOM
908
ND2
ASN
A
62
72.404
−37.432
−0.639
1.00
14.47
A
N


ATOM
911
C
ASN
A
62
69.363
−34.158
−2.661
1.00
14.11
A
C


ATOM
912
O
ASN
A
62
69.476
−33.005
−2.240
1.00
14.02
A
O


ATOM
914
N
VAL
A
63
69.150
−34.446
−3.944
1.00
14.45
A
N


ATOM
915
CA
VAL
A
63
68.998
−33.400
−4.957
1.00
14.74
A
C


ATOM
917
CB
VAL
A
63
68.845
−33.996
−6.377
1.00
14.56
A
C


ATOM
919
CG1
VAL
A
63
68.343
−32.943
−7.354
1.00
14.88
A
C


ATOM
923
CG2
VAL
A
63
70.165
−34.575
−6.854
1.00
14.45
A
C


ATOM
927
C
VAL
A
63
67.796
−32.503
−4.657
1.00
15.15
A
C


ATOM
928
O
VAL
A
63
67.890
−31.278
−4.762
1.00
15.47
A
O


ATOM
930
N
GLN
A
64
66.675
−33.114
−4.281
1.00
15.27
A
N


ATOM
931
CA
GLN
A
64
65.467
−32.355
−3.956
1.00
15.55
A
C


ATOM
933
CB
GLN
A
64
64.254
−33.283
−3.802
1.00
15.45
A
C


ATOM
936
CG
GLN
A
64
63.743
−33.865
−5.114
1.00
13.13
A
C


ATOM
939
CD
GLN
A
64
62.319
−34.385
−5.025
1.00
10.71
A
C


ATOM
940
OE1
GLN
A
64
61.622
−34.470
−6.033
1.00
10.64
A
O


ATOM
941
NE2
GLN
A
64
61.881
−34.731
−3.821
1.00
8.09
A
N


ATOM
944
C
GLN
A
64
65.650
−31.519
−2.688
1.00
15.86
A
C


ATOM
945
O
GLN
A
64
65.402
−30.311
−2.693
1.00
16.06
A
O


ATOM
947
N
ARG
A
65
66.089
−32.167
−1.612
1.00
15.84
A
N


ATOM
948
CA
ARG
A
65
66.241
−31.506
−0.313
1.00
15.98
A
C


ATOM
950
CB
ARG
A
65
66.627
−32.523
0.764
1.00
16.31
A
C


ATOM
953
CG
ARG
A
65
65.505
−33.496
1.113
1.00
18.72
A
C


ATOM
956
CD
ARG
A
65
65.879
−34.400
2.279
1.00
20.75
A
C


ATOM
959
NE
ARG
A
65
66.068
−33.641
3.514
1.00
22.71
A
N


ATOM
961
CZ
ARG
A
65
66.575
−34.133
4.642
1.00
24.75
A
C


ATOM
962
NH1
ARG
A
65
66.956
−35.405
4.721
1.00
25.07
A
N


ATOM
965
NH2
ARG
A
65
66.703
−33.343
5.704
1.00
26.41
A
N


ATOM
968
C
ARG
A
65
67.253
−30.361
−0.342
1.00
15.53
A
C


ATOM
969
O
ARG
A
65
67.039
−29.331
0.297
1.00
15.14
A
O


ATOM
971
N
LEU
A
66
68.338
−30.536
−1.099
1.00
15.13
A
N


ATOM
972
CA
LEU
A
66
69.343
−29.481
−1.287
1.00
14.45
A
C


ATOM
974
CB
LEU
A
66
70.588
−30.046
−1.979
1.00
14.24
A
C


ATOM
977
CG
LEU
A
66
71.505
−30.909
−1.108
1.00
13.57
A
C


ATOM
979
CD1
LEU
A
66
72.413
−31.781
−1.961
1.00
13.45
A
C


ATOM
983
CD2
LEU
A
66
72.329
−30.036
−0.178
1.00
12.36
A
C


ATOM
987
C
LEU
A
66
68.807
−28.271
−2.073
1.00
14.56
A
C


ATOM
988
O
LEU
A
66
69.544
−27.313
−2.332
1.00
14.45
A
O


ATOM
990
N
GLY
A
67
67.533
−28.330
−2.459
1.00
14.51
A
N


ATOM
991
CA
GLY
A
67
66.842
−27.203
−3.059
1.00
14.34
A
C


ATOM
994
C
GLY
A
67
66.968
−27.115
−4.564
1.00
14.63
A
C


ATOM
995
O
GLY
A
67
66.621
−26.093
−5.152
1.00
14.83
A
O


ATOM
997
N
LEU
A
68
67.448
−28.191
−5.189
1.00
15.09
A
N


ATOM
998
CA
LEU
A
68
67.656
−28.234
−6.638
1.00
15.36
A
C


ATOM
1000
CB
LEU
A
68
69.035
−28.828
−6.950
1.00
15.11
A
C


ATOM
1003
CG
LEU
A
68
70.243
−28.122
−6.332
1.00
14.67
A
C


ATOM
1005
CD1
LEU
A
68
71.533
−28.793
−6.779
1.00
13.80
A
C


ATOM
1009
CD2
LEU
A
68
70.256
−26.651
−6.699
1.00
12.27
A
C


ATOM
1013
C
LEU
A
68
66.577
−29.042
−7.371
1.00
15.95
A
C


ATOM
1014
O
LEU
A
68
66.679
−29.258
−8.578
1.00
16.42
A
O


ATOM
1016
N
GLY
A
69
65.543
−29.473
−6.653
1.00
16.33
A
N


ATOM
1017
CA
GLY
A
69
64.496
−30.320
−7.228
1.00
16.45
A
C


ATOM
1020
C
GLY
A
69
63.810
−29.734
−8.449
1.00
16.20
A
C


ATOM
1021
O
GLY
A
69
63.667
−30.410
−9.469
1.00
16.47
A
O


ATOM
1023
N
TYR
A
70
63.392
−28.474
−8.340
1.00
15.95
A
N


ATOM
1024
CA
TYR
A
70
62.726
−27.760
−9.440
1.00
15.71
A
C


ATOM
1026
CB
TYR
A
70
62.501
−26.284
−9.065
1.00
15.82
A
C


ATOM
1029
CG
TYR
A
70
63.755
−25.424
−9.114
1.00
14.12
A
C


ATOM
1030
CD1
TYR
A
70
63.989
−24.561
−10.183
1.00
10.77
A
C


ATOM
1032
CE1
TYR
A
70
65.133
−23.781
−10.237
1.00
10.89
A
C


ATOM
1034
CZ
TYR
A
70
66.066
−23.856
−9.216
1.00
11.24
A
C


ATOM
1035
OH
TYR
A
70
67.208
−23.084
−9.269
1.00
9.98
A
O


ATOM
1037
CE2
TYR
A
70
65.859
−24.705
−8.145
1.00
11.41
A
C


ATOM
1039
CD2
TYR
A
70
64.709
−25.485
−8.100
1.00
12.70
A
C


ATOM
1041
C
TYR
A
70
63.522
−27.841
−10.744
1.00
15.82
A
C


ATOM
1042
O
TYR
A
70
62.951
−27.909
−11.835
1.00
15.94
A
O


ATOM
1044
N
ARG
A
71
64.844
−27.839
−10.607
1.00
15.72
A
N


ATOM
1045
CA
ARG
A
71
65.757
−27.824
−11.737
1.00
15.71
A
C


ATOM
1047
CB
ARG
A
71
67.171
−27.540
−11.224
1.00
15.56
A
C


ATOM
1050
CG
ARG
A
71
68.175
−27.150
−12.286
1.00
16.84
A
C


ATOM
1053
CD
ARG
A
71
69.345
−26.386
−11.679
1.00
17.64
A
C


ATOM
1056
NE
ARG
A
71
69.076
−24.951
−11.600
1.00
18.02
A
N


ATOM
1058
CZ
ARG
A
71
69.124
−24.113
−12.633
1.00
18.91
A
C


ATOM
1059
NH1
ARG
A
71
68.863
−22.828
−12.444
1.00
20.58
A
N


ATOM
1062
NH2
ARG
A
71
69.428
−24.546
−13.856
1.00
18.44
A
N


ATOM
1065
C
ARG
A
71
65.729
−29.131
−12.535
1.00
15.68
A
C


ATOM
1066
O
ARG
A
71
65.790
−29.111
−13.764
1.00
15.69
A
O


ATOM
1068
N
PHE
A
72
65.625
−30.260
−11.838
1.00
15.70
A
N


ATOM
1069
CA
PHE
A
72
65.712
−31.573
−12.478
1.00
15.94
A
C


ATOM
1071
CB
PHE
A
72
66.838
−32.393
−11.835
1.00
15.86
A
C


ATOM
1074
CG
PHE
A
72
68.197
−31.764
−11.949
1.00
13.92
A
C


ATOM
1075
CD1
PHE
A
72
68.891
−31.797
−13.151
1.00
13.93
A
C


ATOM
1077
CE1
PHE
A
72
70.153
−31.229
−13.260
1.00
13.72
A
C


ATOM
1079
CZ
PHE
A
72
70.737
−30.625
−12.157
1.00
13.27
A
C


ATOM
1081
CE2
PHE
A
72
70.057
−30.590
−10.951
1.00
12.76
A
C


ATOM
1083
CD2
PHE
A
72
68.795
−31.161
−10.851
1.00
12.21
A
C


ATOM
1085
C
PHE
A
72
64.407
−32.371
−12.404
1.00
16.42
A
C


ATOM
1086
O
PHE
A
72
64.439
−33.601
−12.348
1.00
16.51
A
O


ATOM
1088
N
GLU
A
73
63.265
−31.686
−12.425
1.00
16.94
A
N


ATOM
1089
CA
GLU
A
73
61.967
−32.365
−12.315
1.00
17.43
A
C


ATOM
1091
CB
GLU
A
73
60.812
−31.361
−12.397
1.00
17.65
A
C


ATOM
1094
CG
GLU
A
73
59.425
−31.997
−12.254
1.00
19.25
A
C


ATOM
1097
CD
GLU
A
73
58.291
−30.983
−12.251
1.00
21.29
A
C


ATOM
1098
OE1
GLU
A
73
58.563
−29.769
−12.127
1.00
22.11
A
O


ATOM
1099
OE2
GLU
A
73
57.121
−31.410
−12.370
1.00
21.96
A
O


ATOM
1100
C
GLU
A
73
61.793
−33.454
−13.379
1.00
17.47
A
C


ATOM
1101
O
GLU
A
73
61.625
−34.628
−13.047
1.00
17.51
A
O


ATOM
1103
N
SER
A
74
61.841
−33.062
−14.649
1.00
17.73
A
N


ATOM
1104
CA
SER
A
74
61.656
−34.004
−15.756
1.00
18.06
A
C


ATOM
1106
CB
SER
A
74
61.792
−33.293
−17.103
1.00
18.17
A
C


ATOM
1109
OG
SER
A
74
63.117
−32.833
−17.303
1.00
19.43
A
O


ATOM
1111
C
SER
A
74
62.648
−35.161
−15.682
1.00
17.97
A
C


ATOM
1112
O
SER
A
74
62.264
−36.317
−15.846
1.00
17.90
A
O


ATOM
1114
N
ASP
A
75
63.915
−34.842
−15.425
1.00
18.18
A
N


ATOM
1115
CA
ASP
A
75
64.961
−35.862
−15.295
1.00
18.40
A
C


ATOM
1117
CB
ASP
A
75
66.344
−35.224
−15.112
1.00
18.40
A
C


ATOM
1120
CG
ASP
A
75
66.754
−34.365
−16.292
1.00
18.51
A
C


ATOM
1121
OD1
ASP
A
75
67.526
−34.847
−17.144
1.00
15.74
A
O


ATOM
1122
OD2
ASP
A
75
66.294
−33.207
−16.370
1.00
20.28
A
O


ATOM
1123
C
ASP
A
75
64.676
−36.804
−14.125
1.00
18.44
A
C


ATOM
1124
O
ASP
A
75
64.923
−38.008
−14.221
1.00
18.88
A
O


ATOM
1126
N
ILE
A
76
64.161
−36.247
−13.030
1.00
18.14
A
N


ATOM
1127
CA
ILE
A
76
63.789
−37.033
−11.854
1.00
17.84
A
C


ATOM
1129
CB
ILE
A
76
63.466
−36.129
−10.640
1.00
17.71
A
C


ATOM
1131
CG1
ILE
A
76
64.758
−35.575
−10.035
1.00
16.61
A
C


ATOM
1134
CD1
ILE
A
76
64.561
−34.317
−9.224
1.00
14.92
A
C


ATOM
1138
CG2
ILE
A
76
62.694
−36.904
−9.580
1.00
17.99
A
C


ATOM
1142
C
ILE
A
76
62.594
−37.930
−12.160
1.00
17.97
A
C


ATOM
1143
O
ILE
A
76
62.658
−39.136
−11.939
1.00
18.10
A
O


ATOM
1145
N
ARG
A
77
61.515
−37.341
−12.674
1.00
18.15
A
N


ATOM
1146
CA
ARG
A
77
60.331
−38.107
−13.077
1.00
18.64
A
C


ATOM
1148
CB
ARG
A
77
59.350
−37.225
−13.851
1.00
18.82
A
C


ATOM
1151
CG
ARG
A
77
58.565
−36.253
−12.988
1.00
20.98
A
C


ATOM
1154
CD
ARG
A
77
57.624
−35.398
−13.835
1.00
23.38
A
C


ATOM
1157
NE
ARG
A
77
56.595
−36.205
−14.492
1.00
24.73
A
N


ATOM
1159
CZ
ARG
A
77
55.471
−36.635
−13.915
1.00
25.64
A
C


ATOM
1160
NH1
ARG
A
77
55.192
−36.346
−12.645
1.00
26.60
A
N


ATOM
1163
NH2
ARG
A
77
54.613
−37.364
−14.618
1.00
25.52
A
N


ATOM
1166
C
ARG
A
77
60.711
−39.312
−13.938
1.00
18.58
A
C


ATOM
1167
O
ARG
A
77
60.240
−40.427
−13.706
1.00
18.61
A
O


ATOM
1169
N
GLY
A
78
61.568
−39.075
−14.928
1.00
18.28
A
N


ATOM
1170
CA
GLY
A
78
62.057
−40.134
−15.802
1.00
18.20
A
C


ATOM
1173
C
GLY
A
78
62.696
−41.279
−15.040
1.00
18.14
A
C


ATOM
1174
O
GLY
A
78
62.502
−42.445
−15.386
1.00
18.30
A
O


ATOM
1176
N
ALA
A
79
63.458
−40.944
−14.001
1.00
18.02
A
N


ATOM
1177
CA
ALA
A
79
64.134
−41.945
−13.180
1.00
18.14
A
C


ATOM
1179
CB
ALA
A
79
65.142
−41.280
−12.258
1.00
18.16
A
C


ATOM
1183
C
ALA
A
79
63.134
−42.763
−12.369
1.00
18.13
A
C


ATOM
1184
O
ALA
A
79
63.227
−43.991
−12.308
1.00
18.34
A
O


ATOM
1186
N
LEU
A
80
62.179
−42.073
−11.754
1.00
18.13
A
N


ATOM
1187
CA
LEU
A
80
61.136
−42.727
−10.969
1.00
18.20
A
C


ATOM
1189
CB
LEU
A
80
60.348
−41.693
−10.161
1.00
17.90
A
C


ATOM
1192
CG
LEU
A
80
61.135
−41.067
−9.009
1.00
16.44
A
C


ATOM
1194
CD1
LEU
A
80
60.478
−39.790
−8.526
1.00
15.42
A
C


ATOM
1198
CD2
LEU
A
80
61.285
−42.059
−7.871
1.00
15.55
A
C


ATOM
1202
C
LEU
A
80
60.189
−43.536
−11.851
1.00
18.82
A
C


ATOM
1203
O
LEU
A
80
59.655
−44.556
−11.418
1.00
18.88
A
O


ATOM
1205
N
ASP
A
81
59.982
−43.083
−13.084
1.00
19.44
A
N


ATOM
1206
CA
ASP
A
81
59.149
−43.819
−14.033
1.00
20.08
A
C


ATOM
1208
CB
ASP
A
81
58.894
−42.984
−15.290
1.00
20.26
A
C


ATOM
1211
CG
ASP
A
81
57.690
−43.464
−16.067
1.00
21.37
A
C


ATOM
1212
OD1
ASP
A
81
57.879
−44.129
−17.108
1.00
23.00
A
O


ATOM
1213
OD2
ASP
A
81
56.554
−43.186
−15.624
1.00
22.87
A
O


ATOM
1214
C
ASP
A
81
59.810
−45.149
−14.406
1.00
20.30
A
C


ATOM
1215
O
ASP
A
81
59.133
−46.174
−14.523
1.00
19.67
A
O


ATOM
1217
N
ARG
A
82
61.131
−45.116
−14.583
1.00
20.83
A
N


ATOM
1218
CA
ARG
A
82
61.920
−46.322
−14.853
1.00
21.36
A
C


ATOM
1220
CB
ARG
A
82
63.315
−45.951
−15.375
1.00
21.67
A
C


ATOM
1223
CG
ARG
A
82
63.351
−45.688
−16.878
1.00
23.80
A
C


ATOM
1226
CD
ARG
A
82
64.738
−45.280
−17.376
1.00
25.75
A
C


ATOM
1229
NE
ARG
A
82
64.961
−43.834
−17.262
1.00
27.68
A
N


ATOM
1231
CZ
ARG
A
82
65.707
−43.227
−16.335
1.00
28.28
A
C


ATOM
1232
NH1
ARG
A
82
66.349
−43.915
−15.389
1.00
27.87
A
N


ATOM
1235
NH2
ARG
A
82
65.813
−41.902
−16.356
1.00
27.78
A
N


ATOM
1238
C
ARG
A
82
62.038
−47.229
−13.623
1.00
21.47
A
C


ATOM
1239
O
ARG
A
82
62.181
−48.446
−13.760
1.00
21.30
A
O


ATOM
1241
N
PHE
A
83
61.981
−46.633
−12.432
1.00
21.68
A
N


ATOM
1242
CA
PHE
A
83
61.970
−47.385
−11.171
1.00
21.75
A
C


ATOM
1244
CB
PHE
A
83
62.026
−46.418
−9.981
1.00
21.95
A
C


ATOM
1247
CG
PHE
A
83
62.097
−47.097
−8.637
1.00
21.67
A
C


ATOM
1248
CD1
PHE
A
83
63.190
−47.877
−8.301
1.00
22.11
A
C


ATOM
1250
CE1
PHE
A
83
63.268
−48.500
−7.064
1.00
21.50
A
C


ATOM
1252
CZ
PHE
A
83
62.250
−48.336
−6.144
1.00
21.28
A
C


ATOM
1254
CE2
PHE
A
83
61.155
−47.554
−6.464
1.00
21.20
A
C


ATOM
1256
CD2
PHE
A
83
61.082
−46.936
−7.704
1.00
21.17
A
C


ATOM
1258
C
PHE
A
83
60.733
−48.277
−11.059
1.00
21.71
A
C


ATOM
1259
O
PHE
A
83
60.838
−49.450
−10.696
1.00
21.49
A
O


ATOM
1261
N
VAL
A
84
59.567
−47.708
−11.365
1.00
21.86
A
N


ATOM
1262
CA
VAL
A
84
58.309
−48.454
−11.376
1.00
21.92
A
C


ATOM
1264
CB
VAL
A
84
57.087
−47.509
−11.496
1.00
21.73
A
C


ATOM
1266
CG1
VAL
A
84
55.821
−48.285
−11.843
1.00
21.28
A
C


ATOM
1270
CG2
VAL
A
84
56.898
−46.731
−10.209
1.00
20.78
A
C


ATOM
1274
C
VAL
A
84
58.297
−49.451
−12.531
1.00
22.75
A
C


ATOM
1275
O
VAL
A
84
58.070
−50.646
−12.323
1.00
22.96
A
O


ATOM
1277
N
SER
A
85
58.560
−48.953
−13.740
1.00
23.25
A
N


ATOM
1278
CA
SER
A
85
58.542
−49.777
−14.959
1.00
23.36
A
C


ATOM
1280
CB
SER
A
85
59.043
−48.969
−16.160
1.00
23.36
A
C


ATOM
1283
OG
SER
A
85
58.267
−47.796
−16.343
1.00
23.72
A
O


ATOM
1285
C
SER
A
85
59.363
−51.059
−14.828
1.00
23.09
A
C


ATOM
1286
O
SER
A
85
58.944
−52.115
−15.300
1.00
22.81
A
O


ATOM
1288
N
SER
A
86
60.521
−50.958
−14.176
1.00
23.31
A
N


ATOM
1289
CA
SER
A
86
61.421
−52.099
−13.992
1.00
23.83
A
C


ATOM
1291
CB
SER
A
86
62.880
−51.626
−14.021
1.00
23.95
A
C


ATOM
1294
OG
SER
A
86
63.188
−50.822
−12.894
1.00
24.38
A
O


ATOM
1296
C
SER
A
86
61.157
−52.885
−12.698
1.00
24.08
A
C


ATOM
1297
O
SER
A
86
61.966
−53.729
−12.312
1.00
24.00
A
O


ATOM
1299
N
GLY
A
87
60.037
−52.604
−12.032
1.00
24.44
A
N


ATOM
1300
CA
GLY
A
87
59.645
−53.333
−10.824
1.00
24.69
A
C


ATOM
1303
C
GLY
A
87
60.534
−53.124
−9.607
1.00
24.77
A
C


ATOM
1304
O
GLY
A
87
60.542
−53.951
−8.693
1.00
24.93
A
O


ATOM
1306
N
GLY
A
88
61.283
−52.024
−9.585
1.00
24.83
A
N


ATOM
1307
CA
GLY
A
88
62.142
−51.701
−8.449
1.00
24.84
A
C


ATOM
1310
C
GLY
A
88
61.331
−51.396
−7.203
1.00
24.89
A
C


ATOM
1311
O
GLY
A
88
61.688
−51.824
−6.104
1.00
24.71
A
O


ATOM
1313
N
PHE
A
89
60.235
−50.657
−7.386
1.00
24.99
A
N


ATOM
1314
CA
PHE
A
89
59.296
−50.336
−6.304
1.00
24.94
A
C


ATOM
1316
CB
PHE
A
89
58.218
−49.363
−6.802
1.00
25.23
A
C


ATOM
1319
CG
PHE
A
89
57.181
−49.012
−5.769
1.00
25.50
A
C


ATOM
1320
CD1
PHE
A
89
57.546
−48.380
−4.588
1.00
25.76
A
C


ATOM
1322
CE1
PHE
A
89
56.592
−48.050
−3.630
1.00
26.18
A
C


ATOM
1324
CZ
PHE
A
89
55.253
−48.346
−3.855
1.00
27.09
A
C


ATOM
1326
CE2
PHE
A
89
54.874
−48.971
−5.033
1.00
27.63
A
C


ATOM
1328
CD2
PHE
A
89
55.838
−49.300
−5.984
1.00
27.27
A
C


ATOM
1330
C
PHE
A
89
58.647
−51.599
−5.746
1.00
24.65
A
C


ATOM
1331
O
PHE
A
89
58.438
−51.709
−4.538
1.00
24.51
A
O


ATOM
1333
N
ASP
A
90
58.330
−52.545
−6.629
1.00
24.41
A
N


ATOM
1334
CA
ASP
A
90
57.825
−53.851
−6.207
1.00
24.29
A
C


ATOM
1336
CB
ASP
A
90
57.210
−54.613
−7.392
1.00
24.60
A
C


ATOM
1339
CG
ASP
A
90
56.123
−55.595
−6.962
1.00
25.71
A
C


ATOM
1340
OD1
ASP
A
90
55.046
−55.135
−6.518
1.00
24.61
A
O


ATOM
1341
OD2
ASP
A
90
56.341
−56.822
−7.078
1.00
27.27
A
O


ATOM
1342
C
ASP
A
90
58.946
−54.677
−5.563
1.00
23.50
A
C


ATOM
1343
O
ASP
A
90
58.687
−55.508
−4.694
1.00
23.34
A
O


ATOM
1345
N
ALA
A
91
60.185
−54.439
−5.992
1.00
22.93
A
N


ATOM
1346
CA
ALA
A
91
61.356
−55.122
−5.434
1.00
22.68
A
C


ATOM
1348
CB
ALA
A
91
62.574
−54.900
−6.326
1.00
22.43
A
C


ATOM
1352
C
ALA
A
91
61.666
−54.683
−3.999
1.00
22.49
A
C


ATOM
1353
O
ALA
A
91
61.957
−55.520
−3.142
1.00
22.56
A
O


ATOM
1355
N
VAL
A
92
61.600
−53.377
−3.741
1.00
22.18
A
N


ATOM
1356
CA
VAL
A
92
61.948
−52.834
−2.421
1.00
21.87
A
C


ATOM
1358
CB
VAL
A
92
62.228
−51.304
−2.465
1.00
22.06
A
C


ATOM
1360
CG1
VAL
A
92
63.296
−50.983
−3.507
1.00
21.68
A
C


ATOM
1364
CG2
VAL
A
92
60.952
−50.515
−2.735
1.00
22.62
A
C


ATOM
1368
C
VAL
A
92
60.890
−53.133
−1.351
1.00
21.46
A
C


ATOM
1369
O
VAL
A
92
61.237
−53.335
−0.189
1.00
21.07
A
O


ATOM
1371
N
THR
A
93
59.614
−53.173
−1.738
1.00
21.50
A
N


ATOM
1372
CA
THR
A
93
58.538
−53.555
−0.809
1.00
21.48
A
C


ATOM
1374
CB
THR
A
93
57.133
−53.525
−1.464
1.00
21.32
A
C


ATOM
1376
OG1
THR
A
93
57.103
−54.398
−2.600
1.00
20.80
A
O


ATOM
1378
CG2
THR
A
93
56.757
−52.110
−1.886
1.00
20.81
A
C


ATOM
1382
C
THR
A
93
58.770
−54.947
−0.226
1.00
21.77
A
C


ATOM
1383
O
THR
A
93
58.340
−55.229
0.894
1.00
22.39
A
O


ATOM
1385
N
LYS
A
94
59.447
−55.807
−0.987
1.00
21.47
A
N


ATOM
1386
CA
LYS
A
94
59.797
−57.146
−0.523
1.00
21.19
A
C


ATOM
1388
CB
LYS
A
94
60.015
−58.087
−1.715
1.00
21.47
A
C


ATOM
1391
CG
LYS
A
94
58.821
−58.222
−2.660
1.00
22.94
A
C


ATOM
1394
CD
LYS
A
94
57.596
−58.829
−1.978
1.00
24.09
A
C


ATOM
1397
CE
LYS
A
94
56.432
−58.970
−2.950
1.00
24.08
A
C


ATOM
1400
NZ
LYS
A
94
55.133
−59.149
−2.242
1.00
24.08
A
N


ATOM
1404
C
LYS
A
94
61.042
−57.168
0.368
1.00
20.63
A
C


ATOM
1405
O
LYS
A
94
61.150
−58.036
1.233
1.00
20.30
A
O


ATOM
1407
N
THR
A
95
61.969
−56.225
0.167
1.00
20.41
A
N


ATOM
1408
CA
THR
A
95
63.302
−56.301
0.795
1.00
20.29
A
C


ATOM
1410
CB
THR
A
95
64.398
−56.575
−0.269
1.00
20.32
A
C


ATOM
1412
OG1
THR
A
95
64.375
−55.546
−1.265
1.00
20.66
A
O


ATOM
1414
CG2
THR
A
95
64.186
−57.931
−0.931
1.00
20.65
A
C


ATOM
1418
C
THR
A
95
63.784
−55.102
1.631
1.00
19.83
A
C


ATOM
1419
O
THR
A
95
64.777
−55.238
2.345
1.00
19.98
A
O


ATOM
1421
N
SER
A
96
63.120
−53.946
1.555
1.00
19.31
A
N


ATOM
1422
CA
SER
A
96
63.620
−52.739
2.247
1.00
18.82
A
C


ATOM
1424
CB
SER
A
96
64.689
−52.051
1.391
1.00
18.43
A
C


ATOM
1427
OG
SER
A
96
65.227
−50.917
2.053
1.00
17.09
A
O


ATOM
1429
C
SER
A
96
62.536
−51.716
2.614
1.00
18.93
A
C


ATOM
1430
O
SER
A
96
61.889
−51.146
1.734
1.00
19.15
A
O


ATOM
1432
N
LEU
A
97
62.364
−51.474
3.916
1.00
18.65
A
N


ATOM
1433
CA
LEU
A
97
61.415
−50.467
4.405
1.00
18.06
A
C


ATOM
1435
CB
LEU
A
97
61.285
−50.521
5.935
1.00
17.85
A
C


ATOM
1438
CG
LEU
A
97
60.459
−49.416
6.612
1.00
16.18
A
C


ATOM
1440
CD1
LEU
A
97
59.070
−49.303
6.001
1.00
15.61
A
C


ATOM
1444
CD2
LEU
A
97
60.358
−49.662
8.105
1.00
13.42
A
C


ATOM
1448
C
LEU
A
97
61.852
−49.076
3.982
1.00
18.03
A
C


ATOM
1449
O
LEU
A
97
61.048
−48.303
3.461
1.00
18.07
A
O


ATOM
1451
N
HIS
A
98
63.126
−48.767
4.217
1.00
18.04
A
N


ATOM
1452
CA
HIS
A
98
63.707
−47.478
3.831
1.00
18.00
A
C


ATOM
1454
CB
HIS
A
98
65.214
−47.475
4.101
1.00
18.04
A
C


ATOM
1457
CG
HIS
A
98
65.911
−46.239
3.626
1.00
18.24
A
C


ATOM
1458
ND1
HIS
A
98
65.437
−44.972
3.886
1.00
18.83
A
N


ATOM
1460
CE1
HIS
A
98
66.252
−44.080
3.351
1.00
20.11
A
C


ATOM
1462
NE2
HIS
A
98
67.241
−44.724
2.757
1.00
20.52
A
N


ATOM
1464
CD2
HIS
A
98
67.051
−46.075
2.915
1.00
19.92
A
C


ATOM
1466
C
HIS
A
98
63.437
−47.172
2.360
1.00
17.56
A
C


ATOM
1467
O
HIS
A
98
62.942
−46.095
2.019
1.00
17.27
A
O


ATOM
1469
N
GLY
A
99
63.761
−48.135
1.502
1.00
17.20
A
N


ATOM
1470
CA
GLY
A
99
63.515
−48.016
0.071
1.00
16.81
A
C


ATOM
1473
C
GLY
A
99
62.044
−47.848
−0.254
1.00
16.25
A
C


ATOM
1474
O
GLY
A
99
61.689
−47.056
−1.122
1.00
16.14
A
O


ATOM
1476
N
THR
A
100
61.192
−48.592
0.449
1.00
15.87
A
N


ATOM
1477
CA
THR
A
100
59.742
−48.502
0.257
1.00
15.58
A
C


ATOM
1479
CB
THR
A
100
59.001
−49.660
0.962
1.00
15.34
A
C


ATOM
1481
OG1
THR
A
100
59.592
−50.906
0.583
1.00
14.29
A
O


ATOM
1483
CG2
THR
A
100
57.525
−49.672
0.583
1.00
14.51
A
C


ATOM
1487
C
THR
A
100
59.184
−47.172
0.767
1.00
15.52
A
C


ATOM
1488
O
THR
A
100
58.246
−46.634
0.186
1.00
15.09
A
O


ATOM
1490
N
ALA
A
101
59.768
−46.652
1.846
1.00
15.65
A
N


ATOM
1491
CA
ALA
A
101
59.332
−45.388
2.444
1.00
15.65
A
C


ATOM
1493
CB
ALA
A
101
59.822
−45.290
3.884
1.00
15.54
A
C


ATOM
1497
C
ALA
A
101
59.814
−44.183
1.638
1.00
15.54
A
C


ATOM
1498
O
ALA
A
101
59.057
−43.237
1.409
1.00
15.42
A
O


ATOM
1500
N
LEU
A
102
61.076
−44.218
1.219
1.00
15.41
A
N


ATOM
1501
CA
LEU
A
102
61.648
−43.146
0.408
1.00
15.42
A
C


ATOM
1503
CB
LEU
A
102
63.157
−43.355
0.241
1.00
15.36
A
C


ATOM
1506
CG
LEU
A
102
63.945
−42.270
−0.501
1.00
14.98
A
C


ATOM
1508
CD1
LEU
A
102
63.702
−40.900
0.116
1.00
15.72
A
C


ATOM
1512
CD2
LEU
A
102
65.430
−42.604
−0.499
1.00
13.41
A
C


ATOM
1516
C
LEU
A
102
60.971
−43.076
−0.961
1.00
15.48
A
C


ATOM
1517
O
LEU
A
102
60.618
−41.993
−1.434
1.00
15.70
A
O


ATOM
1519
N
SER
A
103
60.789
−44.237
−1.585
1.00
15.25
A
N


ATOM
1520
CA
SER
A
103
60.193
−44.320
−2.919
1.00
15.14
A
C


ATOM
1522
CB
SER
A
103
60.410
−45.711
−3.516
1.00
15.40
A
C


ATOM
1525
OG
SER
A
103
59.767
−46.707
−2.738
1.00
16.19
A
O


ATOM
1527
C
SER
A
103
58.702
−44.001
−2.923
1.00
14.61
A
C


ATOM
1528
O
SER
A
103
58.181
−43.506
−3.919
1.00
14.62
A
O


ATOM
1530
N
PHE
A
104
58.019
−44.307
−1.822
1.00
14.22
A
N


ATOM
1531
CA
PHE
A
104
56.601
−43.979
−1.673
1.00
13.75
A
C


ATOM
1533
CB
PHE
A
104
56.071
−44.474
−0.323
1.00
13.69
A
C


ATOM
1536
CG
PHE
A
104
54.603
−44.227
−0.113
1.00
13.93
A
C


ATOM
1537
CD1
PHE
A
104
53.687
−45.255
−0.272
1.00
14.16
A
C


ATOM
1539
CE1
PHE
A
104
52.332
−45.031
−0.075
1.00
15.68
A
C


ATOM
1541
CZ
PHE
A
104
51.878
−43.770
0.287
1.00
15.52
A
C


ATOM
1543
CE2
PHE
A
104
52.780
−42.737
0.450
1.00
15.16
A
C


ATOM
1545
CD2
PHE
A
104
54.137
−42.968
0.254
1.00
15.63
A
C


ATOM
1547
C
PHE
A
104
56.419
−42.475
−1.764
1.00
13.26
A
C


ATOM
1548
O
PHE
A
104
55.580
−41.984
−2.517
1.00
13.35
A
O


ATOM
1550
N
ARG
A
105
57.219
−41.756
−0.983
1.00
12.79
A
N


ATOM
1551
CA
ARG
A
105
57.129
−40.305
−0.889
1.00
12.24
A
C


ATOM
1553
CB
ARG
A
105
58.131
−39.786
0.151
1.00
12.47
A
C


ATOM
1556
CG
ARG
A
105
58.043
−38.289
0.429
1.00
12.65
A
C


ATOM
1559
CD
ARG
A
105
58.675
−37.930
1.765
1.00
12.12
A
C


ATOM
1562
NE
ARG
A
105
60.085
−38.315
1.836
1.00
12.56
A
N


ATOM
1564
CZ
ARG
A
105
61.099
−37.626
1.307
1.00
12.59
A
C


ATOM
1565
NH1
ARG
A
105
60.889
−36.492
0.641
1.00
10.93
A
N


ATOM
1568
NH2
ARG
A
105
62.342
−38.081
1.442
1.00
13.27
A
N


ATOM
1571
C
ARG
A
105
57.377
−39.646
−2.240
1.00
11.50
A
C


ATOM
1572
O
ARG
A
105
56.522
−38.911
−2.739
1.00
11.41
A
O


ATOM
1574
N
LEU
A
106
58.538
−39.929
−2.828
1.00
10.65
A
N


ATOM
1575
CA
LEU
A
106
58.960
−39.289
−4.077
1.00
10.07
A
C


ATOM
1577
CB
LEU
A
106
60.342
−39.797
−4.503
1.00
9.65
A
C


ATOM
1580
CG
LEU
A
106
61.518
−39.446
−3.591
1.00
8.79
A
C


ATOM
1582
CD1
LEU
A
106
62.798
−40.057
−4.123
1.00
7.06
A
C


ATOM
1586
CD2
LEU
A
106
61.665
−37.943
−3.455
1.00
8.58
A
C


ATOM
1590
C
LEU
A
106
57.960
−39.510
−5.210
1.00
10.35
A
C


ATOM
1591
O
LEU
A
106
57.659
−38.591
−5.966
1.00
9.93
A
O


ATOM
1593
N
LEU
A
107
57.448
−40.731
−5.322
1.00
11.25
A
N


ATOM
1594
CA
LEU
A
107
56.482
−41.059
−6.364
1.00
11.96
A
C


ATOM
1596
CB
LEU
A
107
56.168
−42.561
−6.362
1.00
11.90
A
C


ATOM
1599
CG
LEU
A
107
57.282
−43.462
−6.910
1.00
10.93
A
C


ATOM
1601
CD1
LEU
A
107
57.110
−44.907
−6.454
1.00
9.95
A
C


ATOM
1605
CD2
LEU
A
107
57.338
−43.384
−8.426
1.00
9.78
A
C


ATOM
1609
C
LEU
A
107
55.211
−40.227
−6.190
1.00
12.95
A
C


ATOM
1610
O
LEU
A
107
54.855
−39.443
−7.073
1.00
13.19
A
O


ATOM
1612
N
ARG
A
108
54.552
−40.368
−5.041
1.00
13.67
A
N


ATOM
1613
CA
ARG
A
108
53.324
−39.618
−4.765
1.00
14.20
A
C


ATOM
1615
CB
ARG
A
108
52.790
−39.925
−3.364
1.00
14.17
A
C


ATOM
1618
CG
ARG
A
108
51.491
−39.199
−3.039
1.00
14.69
A
C


ATOM
1621
CD
ARG
A
108
50.825
−39.745
−1.794
1.00
15.20
A
C


ATOM
1624
NE
ARG
A
108
50.129
−41.006
−2.043
1.00
15.73
A
N


ATOM
1626
CZ
ARG
A
108
49.489
−41.709
−1.110
1.00
16.84
A
C


ATOM
1627
NH1
ARG
A
108
49.452
−41.284
0.152
1.00
18.23
A
N


ATOM
1630
NH2
ARG
A
108
48.886
−42.847
−1.436
1.00
16.02
A
N


ATOM
1633
C
ARG
A
108
53.527
−38.112
−4.927
1.00
14.71
A
C


ATOM
1634
O
ARG
A
108
52.645
−37.421
−5.434
1.00
15.28
A
O


ATOM
1636
N
GLN
A
109
54.683
−37.613
−4.491
1.00
15.38
A
N


ATOM
1637
CA
GLN
A
109
55.061
−36.209
−4.704
1.00
15.97
A
C


ATOM
1639
CB
GLN
A
109
56.475
−35.945
−4.163
1.00
15.84
A
C


ATOM
1642
CG
GLN
A
109
57.029
−34.541
−4.425
1.00
14.14
A
C


ATOM
1645
CD
GLN
A
109
58.523
−34.431
−4.153
1.00
12.90
A
C


ATOM
1646
OE1
GLN
A
109
59.146
−35.355
−3.631
1.00
11.02
A
O


ATOM
1647
NE2
GLN
A
109
59.102
−33.291
−4.508
1.00
12.83
A
N


ATOM
1650
C
GLN
A
109
55.000
−35.856
−6.190
1.00
16.80
A
C


ATOM
1651
O
GLN
A
109
54.554
−34.764
−6.555
1.00
17.24
A
O


ATOM
1653
N
HIS
A
110
55.441
−36.790
−7.034
1.00
17.12
A
N


ATOM
1654
CA
HIS
A
110
55.471
−36.593
−8.484
1.00
17.38
A
C


ATOM
1656
CB
HIS
A
110
56.786
−37.139
−9.056
1.00
17.33
A
C


ATOM
1659
CG
HIS
A
110
57.991
−36.346
−8.656
1.00
16.17
A
C


ATOM
1660
ND1
HIS
A
110
58.171
−35.032
−9.032
1.00
16.90
A
N


ATOM
1662
CE1
HIS
A
110
59.317
−34.590
−8.545
1.00
16.88
A
C


ATOM
1664
NE2
HIS
A
110
59.888
−35.571
−7.870
1.00
15.81
A
N


ATOM
1666
CD2
HIS
A
110
59.080
−36.681
−7.926
1.00
14.86
A
C


ATOM
1668
C
HIS
A
110
54.264
−37.210
−9.211
1.00
17.87
A
C


ATOM
1669
O
HIS
A
110
54.390
−37.690
−10.344
1.00
17.97
A
O


ATOM
1671
N
GLY
A
111
53.101
−37.208
−8.557
1.00
18.23
A
N


ATOM
1672
CA
GLY
A
111
51.832
−37.543
−9.215
1.00
18.60
A
C


ATOM
1675
C
GLY
A
111
51.538
−39.016
−9.464
1.00
19.18
A
C


ATOM
1676
O
GLY
A
111
50.428
−39.362
−9.877
1.00
19.51
A
O


ATOM
1678
N
PHE
A
112
52.515
−39.888
−9.221
1.00
19.34
A
N


ATOM
1679
CA
PHE
A
112
52.326
−41.326
−9.398
1.00
19.07
A
C


ATOM
1681
CB
PHE
A
112
53.663
−42.064
−9.292
1.00
19.21
A
C


ATOM
1684
CG
PHE
A
112
54.544
−41.904
−10.495
1.00
20.15
A
C


ATOM
1685
CD1
PHE
A
112
54.129
−42.360
−11.740
1.00
21.80
A
C


ATOM
1687
CE1
PHE
A
112
54.945
−42.227
−12.855
1.00
22.75
A
C


ATOM
1689
CZ
PHE
A
112
56.195
−41.642
−12.730
1.00
23.18
A
C


ATOM
1691
CE2
PHE
A
112
56.624
−41.192
−11.489
1.00
22.64
A
C


ATOM
1693
CD2
PHE
A
112
55.800
−41.326
−10.380
1.00
21.27
A
C


ATOM
1695
C
PHE
A
112
51.369
−41.887
−8.357
1.00
18.69
A
C


ATOM
1696
O
PHE
A
112
51.144
−41.275
−7.313
1.00
18.60
A
O


ATOM
1698
N
GLU
A
113
50.817
−43.060
−8.645
1.00
18.61
A
N


ATOM
1699
CA
GLU
A
113
49.921
−43.735
−7.715
1.00
18.65
A
C


ATOM
1701
CB
GLU
A
113
48.699
−44.292
−8.447
1.00
18.82
A
C


ATOM
1704
CG
GLU
A
113
47.633
−43.241
−8.709
1.00
21.49
A
C


ATOM
1707
CD
GLU
A
113
46.566
−43.700
−9.687
1.00
25.30
A
C


ATOM
1708
OE1
GLU
A
113
45.849
−42.829
−10.227
1.00
27.79
A
O


ATOM
1709
OE2
GLU
A
113
46.440
−44.923
−9.917
1.00
27.48
A
O


ATOM
1710
C
GLU
A
113
50.648
−44.841
−6.959
1.00
18.07
A
C


ATOM
1711
O
GLU
A
113
50.854
−45.939
−7.483
1.00
18.36
A
O


ATOM
1713
N
VAL
A
114
51.060
−44.521
−5.735
1.00
17.12
A
N


ATOM
1714
CA
VAL
A
114
51.481
−45.524
−4.765
1.00
16.39
A
C


ATOM
1716
CB
VAL
A
114
52.750
−45.101
−4.008
1.00
15.83
A
C


ATOM
1718
CG1
VAL
A
114
53.919
−45.005
−4.964
1.00
15.16
A
C


ATOM
1722
CG2
VAL
A
114
52.533
−43.784
−3.276
1.00
15.50
A
C


ATOM
1726
C
VAL
A
114
50.335
−45.721
−3.781
1.00
16.53
A
C


ATOM
1727
O
VAL
A
114
49.538
−44.810
−3.572
1.00
16.32
A
O


ATOM
1729
N
SER
A
115
50.247
−46.912
−3.194
1.00
17.04
A
N


ATOM
1730
CA
SER
A
115
49.195
−47.223
−2.228
1.00
17.55
A
C


ATOM
1732
CB
SER
A
115
48.308
−48.355
−2.743
1.00
17.82
A
C


ATOM
1735
OG
SER
A
115
47.197
−48.552
−1.884
1.00
18.67
A
O


ATOM
1737
C
SER
A
115
49.781
−47.609
−0.876
1.00
17.69
A
C


ATOM
1738
O
SER
A
115
50.899
−48.124
−0.795
1.00
17.50
A
O


ATOM
1740
N
GLN
A
116
49.006
−47.374
0.181
1.00
17.82
A
N


ATOM
1741
CA
GLN
A
116
49.454
−47.623
1.555
1.00
17.95
A
C


ATOM
1743
CB
GLN
A
116
48.420
−47.101
2.559
1.00
17.90
A
C


ATOM
1746
CG
GLN
A
116
47.068
−47.810
2.515
1.00
18.34
A
C


ATOM
1749
CD
GLN
A
116
46.133
−47.374
3.628
1.00
18.56
A
C


ATOM
1750
OE1
GLN
A
116
46.556
−46.788
4.625
1.00
17.49
A
O


ATOM
1751
NE2
GLN
A
116
44.849
−47.667
3.464
1.00
20.40
A
N


ATOM
1754
C
GLN
A
116
49.769
−49.092
1.862
1.00
18.13
A
C


ATOM
1755
O
GLN
A
116
50.414
−49.388
2.869
1.00
18.57
A
O


ATOM
1757
N
GLU
A
117
49.310
−50.003
1.004
1.00
17.94
A
N


ATOM
1758
CA
GLU
A
117
49.597
−51.434
1.157
1.00
17.83
A
C


ATOM
1760
CB
GLU
A
117
48.454
−52.279
0.566
1.00
17.98
A
C


ATOM
1763
CG
GLU
A
117
48.249
−52.140
−0.952
1.00
19.01
A
C


ATOM
1766
CD
GLU
A
117
46.780
−52.207
−1.378
1.00
20.24
A
C


ATOM
1767
OE1
GLU
A
117
45.909
−51.625
−0.689
1.00
19.48
A
O


ATOM
1768
OE2
GLU
A
117
46.500
−52.832
−2.424
1.00
20.64
A
O


ATOM
1769
C
GLU
A
117
50.956
−51.847
0.566
1.00
17.49
A
C


ATOM
1770
O
GLU
A
117
51.215
−53.034
0.373
1.00
17.44
A
O


ATOM
1772
N
ALA
A
118
51.817
−50.870
0.282
1.00
17.38
A
N


ATOM
1773
CA
ALA
A
118
53.218
−51.141
−0.044
1.00
17.57
A
C


ATOM
1775
CB
ALA
A
118
53.836
−49.962
−0.770
1.00
17.88
A
C


ATOM
1779
C
ALA
A
118
54.002
−51.431
1.228
1.00
17.50
A
C


ATOM
1780
O
ALA
A
118
55.040
−52.090
1.184
1.00
17.67
A
O


ATOM
1782
N
PHE
A
119
53.498
−50.929
2.354
1.00
17.52
A
N


ATOM
1783
CA
PHE
A
119
54.126
−51.132
3.655
1.00
17.68
A
C


ATOM
1785
CB
PHE
A
119
53.830
−49.945
4.578
1.00
17.42
A
C


ATOM
1788
CG
PHE
A
119
54.301
−48.622
4.038
1.00
15.73
A
C


ATOM
1789
CD1
PHE
A
119
53.399
−47.701
3.526
1.00
14.47
A
C


ATOM
1791
CE1
PHE
A
119
53.833
−46.484
3.029
1.00
15.03
A
C


ATOM
1793
CZ
PHE
A
119
55.181
−46.175
3.039
1.00
15.34
A
C


ATOM
1795
CE2
PHE
A
119
56.091
−47.088
3.544
1.00
14.74
A
C


ATOM
1797
CD2
PHE
A
119
55.649
−48.301
4.040
1.00
14.46
A
C


ATOM
1799
C
PHE
A
119
53.666
−52.422
4.336
1.00
18.67
A
C


ATOM
1800
O
PHE
A
119
54.193
−52.782
5.390
1.00
18.41
A
O


ATOM
1802
N
SER
A
120
52.693
−53.112
3.735
1.00
20.10
A
N


ATOM
1803
CA
SER
A
120
52.070
−54.302
4.342
1.00
20.78
A
C


ATOM
1805
CB
SER
A
120
50.966
−54.859
3.433
1.00
20.80
A
C


ATOM
1808
OG
SER
A
120
51.505
−55.402
2.240
1.00
21.10
A
O


ATOM
1810
C
SER
A
120
53.062
−55.417
4.679
1.00
21.20
A
C


ATOM
1811
O
SER
A
120
52.863
−56.152
5.645
1.00
21.27
A
O


ATOM
1813
N
GLY
A
121
54.121
−55.542
3.884
1.00
22.05
A
N


ATOM
1814
CA
GLY
A
121
55.175
−56.517
4.156
1.00
22.98
A
C


ATOM
1817
C
GLY
A
121
55.878
−56.295
5.487
1.00
23.82
A
C


ATOM
1818
O
GLY
A
121
56.330
−57.252
6.121
1.00
23.57
A
O


ATOM
1820
N
PHE
A
122
55.946
−55.034
5.918
1.00
24.93
A
N


ATOM
1821
CA
PHE
A
122
56.665
−54.646
7.137
1.00
25.54
A
C


ATOM
1823
CB
PHE
A
122
57.384
−53.304
6.922
1.00
25.57
A
C


ATOM
1826
CG
PHE
A
122
58.118
−53.209
5.610
1.00
25.40
A
C


ATOM
1827
CD1
PHE
A
122
59.366
−53.796
5.448
1.00
26.67
A
C


ATOM
1829
CE1
PHE
A
122
60.042
−53.710
4.235
1.00
26.81
A
C


ATOM
1831
CZ
PHE
A
122
59.467
−53.034
3.170
1.00
26.20
A
C


ATOM
1833
CE2
PHE
A
122
58.221
−52.443
3.322
1.00
25.77
A
C


ATOM
1835
CD2
PHE
A
122
57.554
−52.534
4.536
1.00
24.71
A
C


ATOM
1837
C
PHE
A
122
55.734
−54.560
8.358
1.00
26.09
A
C


ATOM
1838
O
PHE
A
122
55.717
−53.553
9.074
1.00
26.28
A
O


ATOM
1840
N
LYS
A
123
54.964
−55.622
8.587
1.00
26.57
A
N


ATOM
1841
CA
LYS
A
123
54.072
−55.719
9.745
1.00
27.02
A
C


ATOM
1843
CB
LYS
A
123
52.632
−55.359
9.349
1.00
27.12
A
C


ATOM
1846
CG
LYS
A
123
52.428
−53.873
9.013
1.00
28.30
A
C


ATOM
1849
CD
LYS
A
123
51.208
−53.615
8.116
1.00
30.27
A
C


ATOM
1852
CE
LYS
A
123
49.967
−53.187
8.895
1.00
30.83
A
C


ATOM
1855
NZ
LYS
A
123
50.115
−51.843
9.535
1.00
30.44
A
N


ATOM
1859
C
LYS
A
123
54.142
−57.139
10.313
1.00
27.21
A
C


ATOM
1860
O
LYS
A
123
54.429
−58.094
9.585
1.00
27.37
A
O


ATOM
1862
N
ASP
A
124
53.888
−57.272
11.613
1.00
27.19
A
N


ATOM
1863
CA
ASP
A
124
53.936
−58.576
12.282
1.00
26.97
A
C


ATOM
1865
CB
ASP
A
124
54.208
−58.395
13.790
1.00
26.80
A
C


ATOM
1868
CG
ASP
A
124
53.015
−57.829
14.555
1.00
26.01
A
C


ATOM
1869
OD1
ASP
A
124
52.076
−57.288
13.930
1.00
23.03
A
O


ATOM
1870
OD2
ASP
A
124
53.020
−57.930
15.800
1.00
25.54
A
O


ATOM
1871
C
ASP
A
124
52.647
−59.374
12.014
1.00
27.07
A
C


ATOM
1872
O
ASP
A
124
51.904
−59.059
11.079
1.00
26.95
A
O


ATOM
1874
N
GLN
A
125
52.393
−60.409
12.816
1.00
27.04
A
N


ATOM
1875
CA
GLN
A
125
51.141
−61.169
12.730
1.00
26.85
A
C


ATOM
1877
CB
GLN
A
125
51.124
−62.297
13.761
1.00
26.80
A
C


ATOM
1880
CG
GLN
A
125
52.054
−63.450
13.455
1.00
26.80
A
C


ATOM
1883
CD
GLN
A
125
51.830
−64.626
14.386
1.00
26.65
A
C


ATOM
1884
OE1
GLN
A
125
51.287
−64.469
15.482
1.00
25.80
A
O


ATOM
1885
NE2
GLN
A
125
52.242
−65.812
13.952
1.00
26.55
A
N


ATOM
1888
C
GLN
A
125
49.908
−60.293
12.956
1.00
26.80
A
C


ATOM
1889
O
GLN
A
125
48.889
−60.462
12.283
1.00
26.98
A
O


ATOM
1891
N
ASN
A
126
50.012
−59.369
13.910
1.00
26.46
A
N


ATOM
1892
CA
ASN
A
126
48.880
−58.542
14.337
1.00
26.12
A
C


ATOM
1894
CB
ASN
A
126
49.113
−58.030
15.762
1.00
25.97
A
C


ATOM
1897
CG
ASN
A
126
48.963
−59.117
16.804
1.00
25.81
A
C


ATOM
1898
OD1
ASN
A
126
48.186
−58.979
17.748
1.00
26.53
A
O


ATOM
1899
ND2
ASN
A
126
49.702
−60.209
16.637
1.00
25.44
A
N


ATOM
1902
C
ASN
A
126
48.554
−57.354
13.429
1.00
26.03
A
C


ATOM
1903
O
ASN
A
126
47.496
−56.744
13.575
1.00
26.32
A
O


ATOM
1905
N
GLY
A
127
49.445
−57.027
12.497
1.00
25.72
A
N


ATOM
1906
CA
GLY
A
127
49.262
−55.850
11.646
1.00
25.62
A
C


ATOM
1909
C
GLY
A
127
49.743
−54.571
12.316
1.00
25.62
A
C


ATOM
1910
O
GLY
A
127
49.235
−53.481
12.040
1.00
25.98
A
O


ATOM
1912
N
ASN
A
128
50.712
−54.716
13.216
1.00
25.32
A
N


ATOM
1913
CA
ASN
A
128
51.451
−53.590
13.771
1.00
24.58
A
C


ATOM
1915
CB
ASN
A
128
51.410
−53.617
15.298
1.00
24.48
A
C


ATOM
1918
CG
ASN
A
128
49.992
−53.673
15.841
1.00
24.48
A
C


ATOM
1919
OD1
ASN
A
128
49.100
−52.975
15.355
1.00
24.27
A
O


ATOM
1920
ND2
ASN
A
128
49.778
−54.508
16.850
1.00
23.51
A
N


ATOM
1923
C
ASN
A
128
52.881
−53.709
13.269
1.00
24.17
A
C


ATOM
1924
O
ASN
A
128
53.380
−54.819
13.064
1.00
23.94
A
O


ATOM
1926
N
PHE
A
129
53.538
−52.574
13.064
1.00
23.75
A
N


ATOM
1927
CA
PHE
A
129
54.868
−52.567
12.453
1.00
23.39
A
C


ATOM
1929
CB
PHE
A
129
55.330
−51.134
12.181
1.00
23.51
A
C


ATOM
1932
CG
PHE
A
129
54.571
−50.461
11.073
1.00
23.75
A
C


ATOM
1933
CD1
PHE
A
129
53.351
−49.843
11.322
1.00
23.30
A
C


ATOM
1935
CE1
PHE
A
129
52.645
−49.226
10.300
1.00
23.78
A
C


ATOM
1937
CZ
PHE
A
129
53.157
−49.223
9.011
1.00
24.34
A
C


ATOM
1939
CE2
PHE
A
129
54.371
−49.841
8.748
1.00
24.80
A
C


ATOM
1941
CD2
PHE
A
129
55.071
−50.456
9.777
1.00
24.15
A
C


ATOM
1943
C
PHE
A
129
55.881
−53.315
13.320
1.00
22.72
A
C


ATOM
1944
O
PHE
A
129
55.797
−53.289
14.549
1.00
22.69
A
O


ATOM
1946
N
LEU
A
130
56.821
−53.997
12.674
1.00
21.98
A
N


ATOM
1947
CA
LEU
A
130
57.774
−54.833
13.395
1.00
21.77
A
C


ATOM
1949
CB
LEU
A
130
58.741
−55.532
12.430
1.00
21.51
A
C


ATOM
1952
CG
LEU
A
130
58.233
−56.805
11.749
1.00
20.32
A
C


ATOM
1954
CD1
LEU
A
130
59.185
−57.238
10.642
1.00
18.63
A
C


ATOM
1958
CD2
LEU
A
130
58.049
−57.920
12.767
1.00
18.91
A
C


ATOM
1962
C
LEU
A
130
58.559
−54.008
14.406
1.00
21.98
A
C


ATOM
1963
O
LEU
A
130
59.271
−53.079
14.033
1.00
22.04
A
O


ATOM
1965
N
GLU
A
131
58.404
−54.344
15.685
1.00
22.19
A
N


ATOM
1966
CA
GLU
A
131
59.208
−53.755
16.756
1.00
22.55
A
C


ATOM
1968
CB
GLU
A
131
59.141
−54.649
18.004
1.00
22.91
A
C


ATOM
1971
CG
GLU
A
131
60.010
−54.215
19.194
1.00
23.48
A
C


ATOM
1974
CD
GLU
A
131
59.514
−52.953
19.885
1.00
24.94
A
C


ATOM
1975
OE1
GLU
A
131
58.423
−52.451
19.536
1.00
26.88
A
O


ATOM
1976
OE2
GLU
A
131
60.221
−52.463
20.790
1.00
25.13
A
O


ATOM
1977
C
GLU
A
131
60.659
−53.593
16.307
1.00
22.63
A
C


ATOM
1978
O
GLU
A
131
61.214
−52.497
16.355
1.00
22.79
A
O


ATOM
1980
N
ASN
A
132
61.246
−54.693
15.839
1.00
22.67
A
N


ATOM
1981
CA
ASN
A
132
62.659
−54.740
15.447
1.00
22.65
A
C


ATOM
1983
CB
ASN
A
132
63.069
−56.179
15.101
1.00
22.74
A
C


ATOM
1986
CG
ASN
A
132
62.220
−56.785
13.992
1.00
24.12
A
C


ATOM
1987
OD1
ASN
A
132
62.359
−56.433
12.818
1.00
24.57
A
O


ATOM
1988
ND2
ASN
A
132
61.339
−57.710
14.362
1.00
25.30
A
N


ATOM
1991
C
ASN
A
132
63.074
−53.793
14.313
1.00
22.61
A
C


ATOM
1992
O
ASN
A
132
64.266
−53.662
14.034
1.00
23.15
A
O


ATOM
1994
N
LEU
A
133
62.110
−53.141
13.661
1.00
22.44
A
N


ATOM
1995
CA
LEU
A
133
62.421
−52.087
12.682
1.00
22.59
A
C


ATOM
1997
CB
LEU
A
133
61.274
−51.905
11.677
1.00
22.57
A
C


ATOM
2000
CG
LEU
A
133
61.086
−53.023
10.646
1.00
22.37
A
C


ATOM
2002
CD1
LEU
A
133
59.755
−52.870
9.926
1.00
20.95
A
C


ATOM
2006
CD2
LEU
A
133
62.236
−53.049
9.647
1.00
21.48
A
C


ATOM
2010
C
LEU
A
133
62.755
−50.743
13.347
1.00
22.64
A
C


ATOM
2011
O
LEU
A
133
63.043
−49.766
12.656
1.00
22.50
A
O


ATOM
2013
N
LYS
A
134
62.710
−50.695
14.679
1.00
22.83
A
N


ATOM
2014
CA
LYS
A
134
63.148
−49.518
15.435
1.00
22.96
A
C


ATOM
2016
CB
LYS
A
134
62.736
−49.645
16.909
1.00
22.77
A
C


ATOM
2019
CG
LYS
A
134
63.555
−50.675
17.698
1.00
22.69
A
C


ATOM
2022
CD
LYS
A
134
62.959
−50.982
19.064
1.00
21.51
A
C


ATOM
2025
CE
LYS
A
134
63.861
−51.921
19.855
1.00
19.87
A
C


ATOM
2028
NZ
LYS
A
134
63.358
−52.166
21.234
1.00
19.19
A
N


ATOM
2032
C
LYS
A
134
64.667
−49.311
15.350
1.00
23.33
A
C


ATOM
2033
O
LYS
A
134
65.152
−48.189
15.500
1.00
23.47
A
O


ATOM
2035
N
GLU
A
135
65.410
−50.393
15.118
1.00
23.60
A
N


ATOM
2036
CA
GLU
A
135
66.874
−50.347
15.129
1.00
23.76
A
C


ATOM
2038
CB
GLU
A
135
67.465
−51.736
15.424
1.00
23.98
A
C


ATOM
2041
CG
GLU
A
135
66.893
−52.454
16.662
1.00
24.91
A
C


ATOM
2044
CD
GLU
A
135
67.236
−51.779
17.991
1.00
26.21
A
C


ATOM
2045
OE1
GLU
A
135
67.594
−50.581
18.003
1.00
25.91
A
O


ATOM
2046
OE2
GLU
A
135
67.140
−52.457
19.037
1.00
26.26
A
O


ATOM
2047
C
GLU
A
135
67.461
−49.797
13.826
1.00
23.56
A
C


ATOM
2048
O
GLU
A
135
68.641
−49.440
13.785
1.00
23.61
A
O


ATOM
2050
N
ASP
A
136
66.648
−49.739
12.770
1.00
23.07
A
N


ATOM
2051
CA
ASP
A
136
67.043
−49.103
11.511
1.00
22.73
A
C


ATOM
2053
CB
ASP
A
136
66.509
−49.903
10.315
1.00
22.88
A
C


ATOM
2056
CG
ASP
A
136
67.141
−49.489
8.990
1.00
23.31
A
C


ATOM
2057
OD1
ASP
A
136
67.675
−48.364
8.882
1.00
24.29
A
O


ATOM
2058
OD2
ASP
A
136
67.096
−50.301
8.043
1.00
24.88
A
O


ATOM
2059
C
ASP
A
136
66.509
−47.671
11.503
1.00
22.28
A
C


ATOM
2060
O
ASP
A
136
65.448
−47.392
10.943
1.00
22.30
A
O


ATOM
2062
N
ILE
A
137
67.263
−46.765
12.119
1.00
21.98
A
N


ATOM
2063
CA
ILE
A
137
66.813
−45.385
12.337
1.00
22.01
A
C


ATOM
2065
CB
ILE
A
137
67.780
−44.618
13.279
1.00
21.91
A
C


ATOM
2067
CG1
ILE
A
137
67.605
−45.087
14.730
1.00
22.58
A
C


ATOM
2070
CD1
ILE
A
137
68.188
−46.460
15.030
1.00
22.59
A
C


ATOM
2074
CG2
ILE
A
137
67.539
−43.117
13.210
1.00
21.61
A
C


ATOM
2078
C
ILE
A
137
66.631
−44.612
11.026
1.00
22.13
A
C


ATOM
2079
O
ILE
A
137
65.838
−43.667
10.958
1.00
21.88
A
O


ATOM
2081
N
LYS
A
138
67.362
−45.025
9.992
1.00
22.24
A
N


ATOM
2082
CA
LYS
A
138
67.242
−44.431
8.659
1.00
21.88
A
C


ATOM
2084
CB
LYS
A
138
68.324
−44.994
7.727
1.00
21.96
A
C


ATOM
2087
CG
LYS
A
138
68.724
−44.056
6.601
1.00
23.45
A
C


ATOM
2090
CD
LYS
A
138
69.512
−44.788
5.522
1.00
25.55
A
C


ATOM
2093
CE
LYS
A
138
70.339
−43.831
4.674
1.00
26.38
A
C


ATOM
2096
NZ
LYS
A
138
71.460
−43.222
5.449
1.00
28.11
A
N


ATOM
2100
C
LYS
A
138
65.854
−44.689
8.062
1.00
21.05
A
C


ATOM
2101
O
LYS
A
138
65.277
−43.812
7.416
1.00
20.86
A
O


ATOM
2103
N
ALA
A
139
65.327
−45.890
8.292
1.00
20.37
A
N


ATOM
2104
CA
ALA
A
139
64.023
−46.291
7.760
1.00
19.96
A
C


ATOM
2106
CB
ALA
A
139
63.890
−47.811
7.792
1.00
19.84
A
C


ATOM
2110
C
ALA
A
139
62.856
−45.639
8.510
1.00
19.48
A
C


ATOM
2111
O
ALA
A
139
61.856
−45.256
7.897
1.00
19.09
A
O


ATOM
2113
N
ILE
A
140
62.987
−45.518
9.830
1.00
18.99
A
N


ATOM
2114
CA
ILE
A
140
61.946
−44.902
10.659
1.00
18.78
A
C


ATOM
2116
CB
ILE
A
140
62.266
−45.017
12.166
1.00
18.67
A
C


ATOM
2118
CG1
ILE
A
140
62.385
−46.485
12.596
1.00
18.06
A
C


ATOM
2121
CD1
ILE
A
140
61.112
−47.284
12.435
1.00
18.60
A
C


ATOM
2125
CG2
ILE
A
140
61.194
−44.314
12.995
1.00
18.20
A
C


ATOM
2129
C
ILE
A
140
61.757
−43.420
10.306
1.00
19.04
A
C


ATOM
2130
O
ILE
A
140
60.635
−42.908
10.342
1.00
19.09
A
O


ATOM
2132
N
LEU
A
141
62.859
−42.741
9.977
1.00
18.82
A
N


ATOM
2133
CA
LEU
A
141
62.812
−41.358
9.492
1.00
18.09
A
C


ATOM
2135
CB
LEU
A
141
64.218
−40.747
9.399
1.00
17.81
A
C


ATOM
2138
CG
LEU
A
141
64.684
−39.929
10.604
1.00
17.40
A
C


ATOM
2140
CD1
LEU
A
141
66.146
−39.540
10.452
1.00
16.73
A
C


ATOM
2144
CD2
LEU
A
141
63.817
−38.692
10.781
1.00
16.04
A
C


ATOM
2148
C
LEU
A
141
62.129
−41.282
8.132
1.00
17.94
A
C


ATOM
2149
O
LEU
A
141
61.260
−40.440
7.917
1.00
18.26
A
O


ATOM
2151
N
SER
A
142
62.523
−42.160
7.215
1.00
17.56
A
N


ATOM
2152
CA
SER
A
142
61.894
−42.205
5.897
1.00
17.58
A
C


ATOM
2154
CB
SER
A
142
62.563
−43.246
4.998
1.00
17.71
A
C


ATOM
2157
OG
SER
A
142
63.697
−42.690
4.359
1.00
18.76
A
O


ATOM
2159
C
SER
A
142
60.401
−42.488
6.016
1.00
17.20
A
C


ATOM
2160
O
SER
A
142
59.585
−41.779
5.427
1.00
17.78
A
O


ATOM
2162
N
LEU
A
143
60.052
−43.516
6.787
1.00
16.32
A
N


ATOM
2163
CA
LEU
A
143
58.651
−43.842
7.046
1.00
15.60
A
C


ATOM
2165
CB
LEU
A
143
58.534
−45.084
7.940
1.00
15.48
A
C


ATOM
2168
CG
LEU
A
143
57.132
−45.436
8.460
1.00
14.83
A
C


ATOM
2170
CD1
LEU
A
143
56.099
−45.438
7.342
1.00
14.92
A
C


ATOM
2174
CD2
LEU
A
143
57.146
−46.774
9.165
1.00
14.54
A
C


ATOM
2178
C
LEU
A
143
57.929
−42.662
7.693
1.00
15.26
A
C


ATOM
2179
O
LEU
A
143
56.819
−42.316
7.292
1.00
15.30
A
O


ATOM
2181
N
TYR
A
144
58.562
−42.052
8.692
1.00
14.88
A
N


ATOM
2182
CA
TYR
A
144
57.996
−40.882
9.359
1.00
14.72
A
C


ATOM
2184
CB
TYR
A
144
58.966
−40.327
10.406
1.00
14.64
A
C


ATOM
2187
CG
TYR
A
144
58.555
−38.994
10.994
1.00
14.77
A
C


ATOM
2188
CD1
TYR
A
144
57.598
−38.919
12.001
1.00
15.26
A
C


ATOM
2190
CE1
TYR
A
144
57.220
−37.698
12.548
1.00
15.65
A
C


ATOM
2192
CZ
TYR
A
144
57.807
−36.534
12.091
1.00
17.33
A
C


ATOM
2193
OH
TYR
A
144
57.435
−35.321
12.629
1.00
19.54
A
O


ATOM
2195
CE2
TYR
A
144
58.761
−36.583
11.090
1.00
17.47
A
C


ATOM
2197
CD2
TYR
A
144
59.131
−37.809
10.550
1.00
16.29
A
C


ATOM
2199
C
TYR
A
144
57.656
−39.801
8.344
1.00
14.69
A
C


ATOM
2200
O
TYR
A
144
56.554
−39.263
8.354
1.00
14.53
A
O


ATOM
2202
N
GLU
A
145
58.605
−39.502
7.464
1.00
14.92
A
N


ATOM
2203
CA
GLU
A
145
58.428
−38.457
6.458
1.00
15.34
A
C


ATOM
2205
CB
GLU
A
145
59.725
−38.257
5.666
1.00
15.45
A
C


ATOM
2208
CG
GLU
A
145
60.888
−37.694
6.479
1.00
16.03
A
C


ATOM
2211
CD
GLU
A
145
60.742
−36.220
6.815
1.00
17.46
A
C


ATOM
2212
OE1
GLU
A
145
59.672
−35.627
6.537
1.00
18.49
A
O


ATOM
2213
OE2
GLU
A
145
61.709
−35.654
7.368
1.00
17.22
A
O


ATOM
2214
C
GLU
A
145
57.277
−38.759
5.493
1.00
15.41
A
C


ATOM
2215
O
GLU
A
145
56.569
−37.845
5.059
1.00
15.63
A
O


ATOM
2217
N
ALA
A
146
57.100
−40.038
5.167
1.00
15.04
A
N


ATOM
2218
CA
ALA
A
146
56.073
−40.475
4.221
1.00
14.82
A
C


ATOM
2220
CB
ALA
A
146
56.363
−41.894
3.752
1.00
14.97
A
C


ATOM
2224
C
ALA
A
146
54.665
−40.406
4.801
1.00
14.76
A
C


ATOM
2225
O
ALA
A
146
53.695
−40.297
4.056
1.00
14.65
A
O


ATOM
2227
N
SER
A
147
54.551
−40.470
6.124
1.00
14.98
A
N


ATOM
2228
CA
SER
A
147
53.245
−40.507
6.778
1.00
15.23
A
C


ATOM
2230
CB
SER
A
147
53.401
−40.795
8.271
1.00
15.04
A
C


ATOM
2233
OG
SER
A
147
53.997
−39.704
8.942
1.00
14.18
A
O


ATOM
2235
C
SER
A
147
52.457
−39.214
6.591
1.00
15.94
A
C


ATOM
2236
O
SER
A
147
51.231
−39.204
6.738
1.00
16.57
A
O


ATOM
2238
N
PHE
A
148
53.165
−38.133
6.271
1.00
16.28
A
N


ATOM
2239
CA
PHE
A
148
52.552
−36.815
6.123
1.00
16.58
A
C


ATOM
2241
CB
PHE
A
148
53.581
−35.727
6.416
1.00
16.42
A
C


ATOM
2244
CG
PHE
A
148
53.926
−35.627
7.867
1.00
17.86
A
C


ATOM
2245
CD1
PHE
A
148
53.239
−34.753
8.694
1.00
19.24
A
C


ATOM
2247
CE1
PHE
A
148
53.538
−34.667
10.042
1.00
19.64
A
C


ATOM
2249
CZ
PHE
A
148
54.529
−35.473
10.579
1.00
20.02
A
C


ATOM
2251
CE2
PHE
A
148
55.214
−36.358
9.763
1.00
19.24
A
C


ATOM
2253
CD2
PHE
A
148
54.905
−36.435
8.416
1.00
19.02
A
C


ATOM
2255
C
PHE
A
148
51.898
−36.586
4.765
1.00
16.73
A
C


ATOM
2256
O
PHE
A
148
51.078
−35.674
4.623
1.00
17.72
A
O


ATOM
2258
N
LEU
A
149
52.241
−37.416
3.780
1.00
16.12
A
N


ATOM
2259
CA
LEU
A
149
51.605
−37.353
2.461
1.00
15.65
A
C


ATOM
2261
CB
LEU
A
149
52.582
−37.802
1.368
1.00
15.36
A
C


ATOM
2264
CG
LEU
A
149
53.836
−36.939
1.206
1.00
14.18
A
C


ATOM
2266
CD1
LEU
A
149
54.944
−37.408
2.137
1.00
13.76
A
C


ATOM
2270
CD2
LEU
A
149
54.315
−36.957
−0.235
1.00
14.24
A
C


ATOM
2274
C
LEU
A
149
50.328
−38.200
2.405
1.00
15.63
A
C


ATOM
2275
O
LEU
A
149
49.735
−38.366
1.337
1.00
15.57
A
O


ATOM
2277
N
ALA
A
150
49.909
−38.723
3.557
1.00
15.70
A
N


ATOM
2278
CA
ALA
A
150
48.736
−39.589
3.650
1.00
15.72
A
C


ATOM
2280
CB
ALA
A
150
48.563
−40.070
5.086
1.00
15.67
A
C


ATOM
2284
C
ALA
A
150
47.456
−38.899
3.170
1.00
15.65
A
C


ATOM
2285
O
ALA
A
150
47.255
−37.706
3.404
1.00
15.79
A
O


ATOM
2287
N
LEU
A
151
46.606
−39.665
2.491
1.00
15.19
A
N


ATOM
2288
CA
LEU
A
151
45.287
−39.199
2.067
1.00
14.89
A
C


ATOM
2290
CB
LEU
A
151
44.936
−39.778
0.698
1.00
14.68
A
C


ATOM
2293
CG
LEU
A
151
45.733
−39.223
−0.478
1.00
13.02
A
C


ATOM
2295
CD1
LEU
A
151
45.541
−40.087
−1.715
1.00
12.24
A
C


ATOM
2299
CD2
LEU
A
151
45.311
−37.794
−0.747
1.00
12.42
A
C


ATOM
2303
C
LEU
A
151
44.241
−39.629
3.087
1.00
14.91
A
C


ATOM
2304
O
LEU
A
151
44.529
−40.431
3.976
1.00
14.52
A
O


ATOM
2306
N
GLU
A
152
43.027
−39.102
2.957
1.00
15.12
A
N


ATOM
2307
CA
GLU
A
152
41.949
−39.471
3.870
1.00
15.70
A
C


ATOM
2309
CB
GLU
A
152
40.662
−38.692
3.572
1.00
16.17
A
C


ATOM
2312
CG
GLU
A
152
40.577
−37.350
4.299
1.00
18.12
A
C


ATOM
2315
CD
GLU
A
152
39.183
−36.749
4.265
1.00
19.18
A
C


ATOM
2316
OE1
GLU
A
152
38.686
−36.455
3.157
1.00
20.47
A
O


ATOM
2317
OE2
GLU
A
152
38.589
−36.566
5.349
1.00
19.32
A
O


ATOM
2318
C
GLU
A
152
41.690
−40.968
3.793
1.00
15.50
A
C


ATOM
2319
O
GLU
A
152
41.623
−41.535
2.704
1.00
15.88
A
O


ATOM
2321
N
GLY
A
153
41.575
−41.602
4.957
1.00
15.25
A
N


ATOM
2322
CA
GLY
A
153
41.298
−43.033
5.039
1.00
14.87
A
C


ATOM
2325
C
GLY
A
153
42.512
−43.935
5.003
1.00
14.62
A
C


ATOM
2326
O
GLY
A
153
42.393
−45.134
5.246
1.00
14.54
A
O


ATOM
2328
N
GLU
A
154
43.680
−43.372
4.705
1.00
14.82
A
N


ATOM
2329
CA
GLU
A
154
44.907
−44.157
4.660
1.00
14.90
A
C


ATOM
2331
CB
GLU
A
154
45.957
−43.488
3.769
1.00
14.85
A
C


ATOM
2334
CG
GLU
A
154
45.527
−43.403
2.305
1.00
15.01
A
C


ATOM
2337
CD
GLU
A
154
46.681
−43.160
1.350
1.00
15.65
A
C


ATOM
2338
OE1
GLU
A
154
46.559
−43.530
0.164
1.00
13.73
A
O


ATOM
2339
OE2
GLU
A
154
47.712
−42.599
1.779
1.00
18.73
A
O


ATOM
2340
C
GLU
A
154
45.421
−44.359
6.079
1.00
14.88
A
C


ATOM
2341
O
GLU
A
154
46.302
−43.638
6.548
1.00
15.13
A
O


ATOM
2343
N
ASN
A
155
44.848
−45.354
6.750
1.00
14.65
A
N


ATOM
2344
CA
ASN
A
155
45.097
−45.587
8.172
1.00
14.39
A
C


ATOM
2346
CB
ASN
A
155
44.043
−46.540
8.758
1.00
14.42
A
C


ATOM
2349
CG
ASN
A
155
44.069
−47.915
8.115
1.00
14.05
A
C


ATOM
2350
OD1
ASN
A
155
44.417
−48.059
6.946
1.00
15.53
A
O


ATOM
2351
ND2
ASN
A
155
43.691
−48.932
8.877
1.00
14.24
A
N


ATOM
2354
C
ASN
A
155
46.499
−46.101
8.492
1.00
14.15
A
C


ATOM
2355
O
ASN
A
155
47.057
−45.750
9.530
1.00
14.42
A
O


ATOM
2357
N
ILE
A
156
47.066
−46.923
7.607
1.00
13.81
A
N


ATOM
2358
CA
ILE
A
156
48.394
−47.515
7.836
1.00
13.39
A
C


ATOM
2360
CB
ILE
A
156
48.774
−48.549
6.731
1.00
13.45
A
C


ATOM
2362
CG1
ILE
A
156
47.886
−49.794
6.827
1.00
13.17
A
C


ATOM
2365
CD1
ILE
A
156
48.364
−50.961
5.977
1.00
12.86
A
C


ATOM
2369
CG2
ILE
A
156
50.234
−48.965
6.847
1.00
12.55
A
C


ATOM
2373
C
ILE
A
156
49.486
−46.447
7.955
1.00
13.02
A
C


ATOM
2374
O
ILE
A
156
50.471
−46.643
8.665
1.00
12.85
A
O


ATOM
2376
N
LEU
A
157
49.304
−45.319
7.275
1.00
12.90
A
N


ATOM
2377
CA
LEU
A
157
50.246
−44.205
7.381
1.00
12.94
A
C


ATOM
2379
CB
LEU
A
157
50.114
−43.261
6.182
1.00
12.67
A
C


ATOM
2382
CG
LEU
A
157
50.865
−43.718
4.929
1.00
11.71
A
C


ATOM
2384
CD1
LEU
A
157
50.470
−45.129
4.540
1.00
11.58
A
C


ATOM
2388
CD2
LEU
A
157
50.623
−42.762
3.774
1.00
12.63
A
C


ATOM
2392
C
LEU
A
157
50.078
−43.444
8.701
1.00
13.44
A
C


ATOM
2393
O
LEU
A
157
51.068
−43.039
9.308
1.00
13.49
A
O


ATOM
2395
N
ASP
A
158
48.833
−43.260
9.144
1.00
14.10
A
N


ATOM
2396
CA
ASP
A
158
48.551
−42.626
10.442
1.00
14.43
A
C


ATOM
2398
CB
ASP
A
158
47.043
−42.417
10.635
1.00
14.42
A
C


ATOM
2401
CG
ASP
A
158
46.488
−41.307
9.759
1.00
15.28
A
C


ATOM
2402
OD1
ASP
A
158
47.035
−40.184
9.789
1.00
14.96
A
O


ATOM
2403
OD2
ASP
A
158
45.494
−41.555
9.045
1.00
17.78
A
O


ATOM
2404
C
ASP
A
158
49.113
−43.454
11.597
1.00
14.67
A
C


ATOM
2405
O
ASP
A
158
49.622
−42.899
12.573
1.00
14.25
A
O


ATOM
2407
N
GLU
A
159
48.999
−44.778
11.476
1.00
15.29
A
N


ATOM
2408
CA
GLU
A
159
49.677
−45.723
12.370
1.00
15.67
A
C


ATOM
2410
CB
GLU
A
159
49.261
−47.160
12.052
1.00
15.79
A
C


ATOM
2413
CG
GLU
A
159
47.811
−47.499
12.324
1.00
16.58
A
C


ATOM
2416
CD
GLU
A
159
47.447
−48.900
11.846
1.00
18.81
A
C


ATOM
2417
OE1
GLU
A
159
48.362
−49.720
11.591
1.00
17.33
A
O


ATOM
2418
OE2
GLU
A
159
46.237
−49.182
11.725
1.00
22.11
A
O


ATOM
2419
C
GLU
A
159
51.198
−45.631
12.218
1.00
15.73
A
C


ATOM
2420
O
GLU
A
159
51.934
−45.685
13.205
1.00
15.90
A
O


ATOM
2422
N
ALA
A
160
51.656
−45.525
10.971
1.00
15.58
A
N


ATOM
2423
CA
ALA
A
160
53.082
−45.445
10.660
1.00
15.31
A
C


ATOM
2425
CB
ALA
A
160
53.297
−45.451
9.153
1.00
15.15
A
C


ATOM
2429
C
ALA
A
160
53.726
−44.210
11.276
1.00
15.28
A
C


ATOM
2430
O
ALA
A
160
54.895
−44.244
11.651
1.00
15.24
A
O


ATOM
2432
N
LYS
A
161
52.965
−43.124
11.373
1.00
15.64
A
N


ATOM
2433
CA
LYS
A
161
53.459
−41.904
11.996
1.00
16.20
A
C


ATOM
2435
CB
LYS
A
161
52.467
−40.748
11.813
1.00
16.58
A
C


ATOM
2438
CG
LYS
A
161
53.056
−39.373
12.115
1.00
17.99
A
C


ATOM
2441
CD
LYS
A
161
51.982
−38.301
12.267
1.00
19.18
A
C


ATOM
2444
CE
LYS
A
161
51.280
−38.008
10.956
1.00
20.22
A
C


ATOM
2447
NZ
LYS
A
161
50.469
−36.762
11.043
1.00
22.18
A
N


ATOM
2451
C
LYS
A
161
53.714
−42.165
13.479
1.00
16.44
A
C


ATOM
2452
O
LYS
A
161
54.843
−42.022
13.951
1.00
16.58
A
O


ATOM
2454
N
VAL
A
162
52.671
−42.579
14.197
1.00
16.53
A
N


ATOM
2455
CA
VAL
A
162
52.759
−42.814
15.645
1.00
16.48
A
C


ATOM
2457
CB
VAL
A
162
51.412
−43.299
16.237
1.00
16.23
A
C


ATOM
2459
CG1
VAL
A
162
51.528
−43.498
17.742
1.00
16.10
A
C


ATOM
2463
CG2
VAL
A
162
50.302
−42.307
15.923
1.00
16.13
A
C


ATOM
2467
C
VAL
A
162
53.861
−43.822
15.995
1.00
16.54
A
C


ATOM
2468
O
VAL
A
162
54.609
−43.616
16.952
1.00
16.62
A
O


ATOM
2470
N
PHE
A
163
53.955
−44.899
15.215
1.00
16.67
A
N


ATOM
2471
CA
PHE
A
163
55.011
−45.905
15.387
1.00
16.71
A
C


ATOM
2473
CB
PHE
A
163
54.803
−47.072
14.417
1.00
16.07
A
C


ATOM
2476
CG
PHE
A
163
55.907
−48.094
14.446
1.00
13.86
A
C


ATOM
2477
CD1
PHE
A
163
55.862
−49.160
15.332
1.00
12.47
A
C


ATOM
2479
CE1
PHE
A
163
56.880
−50.105
15.360
1.00
11.52
A
C


ATOM
2481
CZ
PHE
A
163
57.957
−49.986
14.497
1.00
10.81
A
C


ATOM
2483
CE2
PHE
A
163
58.014
−48.928
13.610
1.00
11.67
A
C


ATOM
2485
CD2
PHE
A
163
56.992
−47.988
13.587
1.00
12.64
A
C


ATOM
2487
C
PHE
A
163
56.406
−45.311
15.182
1.00
17.79
A
C


ATOM
2488
O
PHE
A
163
57.368
−45.724
15.838
1.00
17.93
A
O


ATOM
2490
N
ALA
A
164
56.511
−44.355
14.262
1.00
18.68
A
N


ATOM
2491
CA
ALA
A
164
57.782
−43.701
13.968
1.00
19.35
A
C


ATOM
2493
CB
ALA
A
164
57.721
−43.017
12.611
1.00
19.35
A
C


ATOM
2497
C
ALA
A
164
58.149
−42.697
15.060
1.00
19.82
A
C


ATOM
2498
O
ALA
A
164
59.254
−42.742
15.602
1.00
20.21
A
O


ATOM
2500
N
ILE
A
165
57.217
−41.803
15.383
1.00
20.14
A
N


ATOM
2501
CA
ILE
A
165
57.441
−40.775
16.404
1.00
20.35
A
C


ATOM
2503
CB
ILE
A
165
56.150
−39.959
16.698
1.00
20.49
A
C


ATOM
2505
CG1
ILE
A
165
55.797
−39.062
15.508
1.00
20.83
A
C


ATOM
2508
CD1
ILE
A
165
54.500
−38.292
15.676
1.00
21.96
A
C


ATOM
2512
CG2
ILE
A
165
56.325
−39.092
17.939
1.00
20.43
A
C


ATOM
2516
C
ILE
A
165
57.949
−41.397
17.703
1.00
20.24
A
C


ATOM
2517
O
ILE
A
165
59.035
−41.062
18.173
1.00
19.62
A
O


ATOM
2519
N
SER
A
166
57.167
−42.320
18.258
1.00
20.69
A
N


ATOM
2520
CA
SER
A
166
57.470
−42.919
19.560
1.00
21.20
A
C


ATOM
2522
CB
SER
A
166
56.381
−43.923
19.958
1.00
21.36
A
C


ATOM
2525
OG
SER
A
166
56.287
−44.983
19.023
1.00
21.83
A
O


ATOM
2527
C
SER
A
166
58.846
−43.587
19.616
1.00
21.27
A
C


ATOM
2528
O
SER
A
166
59.468
−43.630
20.679
1.00
21.20
A
O


ATOM
2530
N
HIS
A
167
59.314
−44.102
18.480
1.00
21.52
A
N


ATOM
2531
CA
HIS
A
167
60.649
−44.703
18.398
1.00
21.98
A
C


ATOM
2533
CB
HIS
A
167
60.677
−45.836
17.366
1.00
22.19
A
C


ATOM
2536
CG
HIS
A
167
60.128
−47.131
17.881
1.00
23.11
A
C


ATOM
2537
ND1
HIS
A
167
58.969
−47.696
17.395
1.00
23.65
A
N


ATOM
2539
CE1
HIS
A
167
58.730
−48.826
18.038
1.00
24.10
A
C


ATOM
2541
NE2
HIS
A
167
59.690
−49.012
18.926
1.00
23.55
A
N


ATOM
2543
CD2
HIS
A
167
60.575
−47.964
18.851
1.00
23.42
A
C


ATOM
2545
C
HIS
A
167
61.748
−43.677
18.099
1.00
22.06
A
C


ATOM
2546
O
HIS
A
167
62.900
−43.884
18.480
1.00
21.93
A
O


ATOM
2548
N
LEU
A
168
61.397
−42.584
17.422
1.00
22.44
A
N


ATOM
2549
CA
LEU
A
168
62.342
−41.486
17.174
1.00
22.76
A
C


ATOM
2551
CB
LEU
A
168
61.860
−40.590
16.025
1.00
22.70
A
C


ATOM
2554
CG
LEU
A
168
61.921
−41.116
14.589
1.00
22.46
A
C


ATOM
2556
CD1
LEU
A
168
61.482
−40.020
13.632
1.00
22.16
A
C


ATOM
2560
CD2
LEU
A
168
63.317
−41.601
14.234
1.00
23.20
A
C


ATOM
2564
C
LEU
A
168
62.542
−40.614
18.412
1.00
23.43
A
C


ATOM
2565
O
LEU
A
168
63.648
−40.140
18.673
1.00
23.50
A
O


ATOM
2567
N
LYS
A
169
61.465
−40.408
19.165
1.00
24.25
A
N


ATOM
2568
CA
LYS
A
169
61.446
−39.435
20.259
1.00
24.95
A
C


ATOM
2570
CB
LYS
A
169
60.007
−39.234
20.749
1.00
24.99
A
C


ATOM
2573
CG
LYS
A
169
59.788
−37.951
21.533
1.00
26.38
A
C


ATOM
2576
CD
LYS
A
169
58.329
−37.522
21.493
1.00
27.59
A
C


ATOM
2579
CE
LYS
A
169
58.115
−36.206
22.217
1.00
28.00
A
C


ATOM
2582
NZ
LYS
A
169
56.702
−35.756
22.113
1.00
29.00
A
N


ATOM
2586
C
LYS
A
169
62.353
−39.802
21.438
1.00
25.45
A
C


ATOM
2587
O
LYS
A
169
62.861
−38.917
22.128
1.00
25.46
A
O


ATOM
2589
N
GLU
A
170
62.560
−41.097
21.661
1.00
26.28
A
N


ATOM
2590
CA
GLU
A
170
63.351
−41.570
22.798
1.00
27.20
A
C


ATOM
2592
CB
GLU
A
170
62.625
−42.725
23.502
1.00
27.52
A
C


ATOM
2595
CG
GLU
A
170
61.178
−42.416
23.892
1.00
29.00
A
C


ATOM
2598
CD
GLU
A
170
61.051
−41.184
24.776
1.00
30.77
A
C


ATOM
2599
OE1
GLU
A
170
61.736
−41.127
25.821
1.00
30.80
A
O


ATOM
2600
OE2
GLU
A
170
60.266
−40.274
24.426
1.00
31.83
A
O


ATOM
2601
C
GLU
A
170
64.756
−41.997
22.365
1.00
27.59
A
C


ATOM
2602
O
GLU
A
170
65.223
−43.086
22.715
1.00
27.53
A
O


ATOM
2604
N
LEU
A
171
65.424
−41.127
21.609
1.00
27.91
A
N


ATOM
2605
CA
LEU
A
171
66.775
−41.390
21.120
1.00
28.20
A
C


ATOM
2607
CB
LEU
A
171
66.784
−41.495
19.594
1.00
27.90
A
C


ATOM
2610
CG
LEU
A
171
65.896
−42.582
18.983
1.00
27.09
A
C


ATOM
2612
CD1
LEU
A
171
66.044
−42.582
17.469
1.00
25.97
A
C


ATOM
2616
CD2
LEU
A
171
66.215
−43.960
19.554
1.00
25.82
A
C


ATOM
2620
C
LEU
A
171
67.720
−40.283
21.570
1.00
28.93
A
C


ATOM
2621
O
LEU
A
171
67.390
−39.099
21.468
1.00
28.94
A
O


ATOM
2623
N
SER
A
172
68.895
−40.680
22.060
1.00
29.73
A
N


ATOM
2624
CA
SER
A
172
69.882
−39.745
22.605
1.00
30.12
A
C


ATOM
2626
CB
SER
A
172
70.465
−40.293
23.905
1.00
30.03
A
C


ATOM
2629
OG
SER
A
172
69.435
−40.707
24.783
1.00
30.49
A
O


ATOM
2631
C
SER
A
172
71.012
−39.473
21.617
1.00
30.47
A
C


ATOM
2632
O
SER
A
172
71.235
−40.241
20.678
1.00
30.80
A
O


ATOM
2634
N
GLU
A
173
71.733
−38.381
21.855
1.00
30.63
A
N


ATOM
2635
CA
GLU
A
173
72.807
−37.942
20.964
1.00
30.79
A
C


ATOM
2637
CB
GLU
A
173
73.199
−36.492
21.287
1.00
30.90
A
C


ATOM
2640
CG
GLU
A
173
73.888
−35.747
20.143
1.00
31.84
A
C


ATOM
2643
CD
GLU
A
173
73.898
−34.232
20.335
1.00
33.26
A
C


ATOM
2644
OE1
GLU
A
173
72.839
−33.658
20.672
1.00
33.46
A
O


ATOM
2645
OE2
GLU
A
173
74.964
−33.611
20.136
1.00
34.47
A
O


ATOM
2646
C
GLU
A
173
74.038
−38.862
21.017
1.00
30.75
A
C


ATOM
2647
O
GLU
A
173
74.807
−38.913
20.057
1.00
30.90
A
O


ATOM
2649
N
GLU
A
174
74.221
−39.585
22.125
1.00
30.65
A
N


ATOM
2650
CA
GLU
A
174
75.338
−40.532
22.262
1.00
30.58
A
C


ATOM
2652
CB
GLU
A
174
75.627
−40.857
23.733
1.00
30.55
A
C


ATOM
2655
CG
GLU
A
174
75.957
−39.663
24.614
1.00
30.63
A
C


ATOM
2658
CD
GLU
A
174
74.768
−39.198
25.430
1.00
30.50
A
C


ATOM
2659
OE1
GLU
A
174
73.749
−38.804
24.825
1.00
29.37
A
O


ATOM
2660
OE2
GLU
A
174
74.852
−39.230
26.675
1.00
30.66
A
O


ATOM
2661
C
GLU
A
174
75.073
−41.847
21.530
1.00
30.62
A
C


ATOM
2662
O
GLU
A
174
75.991
−42.432
20.948
1.00
30.96
A
O


ATOM
2664
N
LYS
A
175
73.822
−42.308
21.575
1.00
30.19
A
N


ATOM
2665
CA
LYS
A
175
73.443
−43.617
21.030
1.00
29.66
A
C


ATOM
2667
CB
LYS
A
175
71.983
−43.959
21.363
1.00
29.85
A
C


ATOM
2670
CG
LYS
A
175
71.603
−43.849
22.838
1.00
30.60
A
C


ATOM
2673
CD
LYS
A
175
72.325
−44.864
23.703
1.00
30.80
A
C


ATOM
2676
CE
LYS
A
175
71.987
−44.658
25.168
1.00
30.86
A
C


ATOM
2679
NZ
LYS
A
175
72.453
−45.794
26.002
1.00
31.13
A
N


ATOM
2683
C
LYS
A
175
73.628
−43.623
19.521
1.00
28.93
A
C


ATOM
2684
O
LYS
A
175
74.345
−44.461
18.973
1.00
28.70
A
O


ATOM
2686
N
ILE
A
176
72.973
−42.670
18.865
1.00
28.25
A
N


ATOM
2687
CA
ILE
A
176
73.092
−42.490
17.424
1.00
27.93
A
C


ATOM
2689
CB
ILE
A
176
71.735
−42.112
16.764
1.00
27.94
A
C


ATOM
2691
CG1
ILE
A
176
71.039
−40.966
17.514
1.00
28.01
A
C


ATOM
2694
CD1
ILE
A
176
69.948
−40.282
16.713
1.00
27.59
A
C


ATOM
2698
CG2
ILE
A
176
70.822
−43.325
16.716
1.00
27.61
A
C


ATOM
2702
C
ILE
A
176
74.144
−41.421
17.143
1.00
27.68
A
C


ATOM
2703
O
ILE
A
176
74.655
−40.788
18.067
1.00
27.18
A
O


ATOM
2705
N
GLY
A
177
74.473
−41.237
15.868
1.00
27.66
A
N


ATOM
2706
CA
GLY
A
177
75.460
−40.244
15.466
1.00
27.56
A
C


ATOM
2709
C
GLY
A
177
74.987
−38.831
15.744
1.00
27.45
A
C


ATOM
2710
O
GLY
A
177
73.785
−38.552
15.719
1.00
27.69
A
O


ATOM
2712
N
LYS
A
178
75.938
−37.941
16.015
1.00
27.13
A
N


ATOM
2713
CA
LYS
A
178
75.639
−36.526
16.218
1.00
26.85
A
C


ATOM
2715
CB
LYS
A
178
76.934
−35.721
16.371
1.00
27.05
A
C


ATOM
2718
CG
LYS
A
178
76.737
−34.303
16.900
1.00
27.43
A
C


ATOM
2721
CD
LYS
A
178
78.075
−33.632
17.203
1.00
27.38
A
C


ATOM
2724
CE
LYS
A
178
77.917
−32.490
18.197
1.00
27.26
A
C


ATOM
2727
NZ
LYS
A
178
79.230
−31.954
18.642
1.00
27.88
A
N


ATOM
2731
C
LYS
A
178
74.822
−35.984
15.048
1.00
26.49
A
C


ATOM
2732
O
LYS
A
178
73.928
−35.161
15.238
1.00
26.01
A
O


ATOM
2734
N
GLU
A
179
75.130
−36.465
13.843
1.00
26.38
A
N


ATOM
2735
CA
GLU
A
179
74.427
−36.033
12.635
1.00
26.59
A
C


ATOM
2737
CB
GLU
A
179
75.284
−36.264
11.379
1.00
26.76
A
C


ATOM
2740
CG
GLU
A
179
75.652
−37.715
11.067
1.00
27.14
A
C


ATOM
2743
CD
GLU
A
179
76.355
−37.860
9.721
1.00
27.77
A
C


ATOM
2744
OE1
GLU
A
179
76.641
−39.008
9.321
1.00
29.07
A
O


ATOM
2745
OE2
GLU
A
179
76.623
−36.833
9.060
1.00
27.01
A
O


ATOM
2746
C
GLU
A
179
73.033
−36.657
12.469
1.00
26.24
A
C


ATOM
2747
O
GLU
A
179
72.139
−36.021
11.903
1.00
26.60
A
O


ATOM
2749
N
LEU
A
180
72.846
−37.887
12.949
1.00
25.43
A
N


ATOM
2750
CA
LEU
A
180
71.525
−38.531
12.901
1.00
24.84
A
C


ATOM
2752
CB
LEU
A
180
71.613
−40.033
13.201
1.00
24.93
A
C


ATOM
2755
CG
LEU
A
180
71.959
−40.949
12.023
1.00
25.07
A
C


ATOM
2757
CD1
LEU
A
180
72.178
−42.374
12.519
1.00
24.77
A
C


ATOM
2761
CD2
LEU
A
180
70.874
−40.911
10.949
1.00
23.22
A
C


ATOM
2765
C
LEU
A
180
70.549
−37.866
13.866
1.00
24.29
A
C


ATOM
2766
O
LEU
A
180
69.380
−37.671
13.531
1.00
24.25
A
O


ATOM
2768
N
ALA
A
181
71.031
−37.522
15.058
1.00
23.73
A
N


ATOM
2769
CA
ALA
A
181
70.229
−36.777
16.031
1.00
23.30
A
C


ATOM
2771
CB
ALA
A
181
71.011
−36.575
17.321
1.00
23.36
A
C


ATOM
2775
C
ALA
A
181
69.789
−35.428
15.462
1.00
22.75
A
C


ATOM
2776
O
ALA
A
181
68.650
−35.010
15.655
1.00
22.37
A
O


ATOM
2778
N
GLU
A
182
70.702
−34.758
14.762
1.00
22.59
A
N


ATOM
2779
CA
GLU
A
182
70.399
−33.493
14.088
1.00
22.35
A
C


ATOM
2781
CB
GLU
A
182
71.677
−32.858
13.517
1.00
22.71
A
C


ATOM
2784
CG
GLU
A
182
72.564
−32.200
14.578
1.00
24.48
A
C


ATOM
2787
CD
GLU
A
182
73.892
−31.690
14.031
1.00
25.90
A
C


ATOM
2788
OE1
GLU
A
182
74.533
−32.407
13.229
1.00
26.63
A
O


ATOM
2789
OE2
GLU
A
182
74.302
−30.573
14.418
1.00
25.24
A
O


ATOM
2790
C
GLU
A
182
69.371
−33.694
12.980
1.00
21.48
A
C


ATOM
2791
O
GLU
A
182
68.562
−32.806
12.712
1.00
21.64
A
O


ATOM
2793
N
GLN
A
183
69.408
−34.862
12.345
1.00
20.42
A
N


ATOM
2794
CA
GLN
A
183
68.426
−35.223
11.328
1.00
19.78
A
C


ATOM
2796
CB
GLN
A
183
68.890
−36.458
10.548
1.00
19.69
A
C


ATOM
2799
CG
GLN
A
183
68.480
−36.456
9.080
1.00
20.17
A
C


ATOM
2802
CD
GLN
A
183
69.261
−35.455
8.240
1.00
19.79
A
C


ATOM
2803
OE1
GLN
A
183
68.826
−35.068
7.154
1.00
18.23
A
O


ATOM
2804
NE2
GLN
A
183
70.419
−35.035
8.737
1.00
21.56
A
N


ATOM
2807
C
GLN
A
183
67.065
−35.499
11.973
1.00
19.19
A
C


ATOM
2808
O
GLN
A
183
66.025
−35.090
11.450
1.00
18.90
A
O


ATOM
2810
N
VAL
A
184
67.084
−36.194
13.108
1.00
18.65
A
N


ATOM
2811
CA
VAL
A
184
65.863
−36.523
13.844
1.00
18.22
A
C


ATOM
2813
CB
VAL
A
184
66.131
−37.581
14.940
1.00
18.01
A
C


ATOM
2815
CG1
VAL
A
184
66.397
−38.935
14.306
1.00
17.80
A
C


ATOM
2819
CG2
VAL
A
184
64.960
−37.673
15.903
1.00
17.60
A
C


ATOM
2823
C
VAL
A
184
65.237
−35.280
14.471
1.00
18.09
A
C


ATOM
2824
O
VAL
A
184
64.024
−35.091
14.389
1.00
18.22
A
O


ATOM
2826
N
ASN
A
185
66.066
−34.443
15.094
1.00
18.01
A
N


ATOM
2827
CA
ASN
A
185
65.602
−33.185
15.689
1.00
18.08
A
C


ATOM
2829
CB
ASN
A
185
66.741
−32.481
16.437
1.00
18.30
A
C


ATOM
2832
CG
ASN
A
185
67.082
−33.151
17.759
1.00
18.99
A
C


ATOM
2833
OD1
ASN
A
185
66.855
−34.347
17.947
1.00
20.86
A
O


ATOM
2834
ND2
ASN
A
185
67.634
−32.376
18.684
1.00
19.63
A
N


ATOM
2837
C
ASN
A
185
65.010
−32.239
14.646
1.00
18.07
A
C


ATOM
2838
O
ASN
A
185
64.042
−31.531
14.923
1.00
17.94
A
O


ATOM
2840
N
HIS
A
186
65.600
−32.235
13.453
1.00
18.13
A
N


ATOM
2841
CA
HIS
A
186
65.084
−31.459
12.322
1.00
18.18
A
C


ATOM
2843
CB
HIS
A
186
66.104
−31.468
11.180
1.00
17.97
A
C


ATOM
2846
CG
HIS
A
186
65.745
−30.580
10.028
1.00
16.43
A
C


ATOM
2847
ND1
HIS
A
186
65.727
−29.205
10.126
1.00
14.28
A
N


ATOM
2849
CE1
HIS
A
186
65.396
−28.688
8.956
1.00
13.38
A
C


ATOM
2851
NE2
HIS
A
186
65.205
−29.678
8.102
1.00
14.26
A
N


ATOM
2853
CD2
HIS
A
186
65.423
−30.871
8.746
1.00
14.62
A
C


ATOM
2855
C
HIS
A
186
63.741
−32.012
11.834
1.00
18.27
A
C


ATOM
2856
O
HIS
A
186
62.784
−31.261
11.657
1.00
18.39
A
O


ATOM
2858
N
ALA
A
187
63.679
−33.325
11.625
1.00
18.10
A
N


ATOM
2859
CA
ALA
A
187
62.454
−33.979
11.159
1.00
17.75
A
C


ATOM
2861
CB
ALA
A
187
62.726
−35.439
10.848
1.00
17.93
A
C


ATOM
2865
C
ALA
A
187
61.315
−33.859
12.173
1.00
17.45
A
C


ATOM
2866
O
ALA
A
187
60.161
−33.643
11.797
1.00
17.00
A
O


ATOM
2868
N
LEU
A
188
61.646
−33.998
13.456
1.00
17.36
A
N


ATOM
2869
CA
LEU
A
188
60.648
−33.889
14.526
1.00
17.21
A
C


ATOM
2871
CB
LEU
A
188
61.154
−34.531
15.826
1.00
16.89
A
C


ATOM
2874
CG
LEU
A
188
61.033
−36.059
15.872
1.00
16.43
A
C


ATOM
2876
CD1
LEU
A
188
61.936
−36.663
16.933
1.00
15.33
A
C


ATOM
2880
CD2
LEU
A
188
59.586
−36.471
16.107
1.00
16.80
A
C


ATOM
2884
C
LEU
A
188
60.216
−32.442
14.773
1.00
17.11
A
C


ATOM
2885
O
LEU
A
188
59.104
−32.205
15.245
1.00
17.54
A
O


ATOM
2887
N
GLU
A
189
61.088
−31.484
14.462
1.00
16.53
A
N


ATOM
2888
CA
GLU
A
189
60.711
−30.071
14.493
1.00
16.03
A
C


ATOM
2890
CB
GLU
A
189
61.894
−29.181
14.088
1.00
16.08
A
C


ATOM
2893
CG
GLU
A
189
61.639
−27.679
14.221
1.00
17.05
A
C


ATOM
2896
CD
GLU
A
189
62.570
−26.845
13.357
1.00
18.24
A
C


ATOM
2897
OE1
GLU
A
189
62.631
−27.099
12.136
1.00
18.22
A
O


ATOM
2898
OE2
GLU
A
189
63.229
−25.927
13.893
1.00
18.67
A
O


ATOM
2899
C
GLU
A
189
59.554
−29.859
13.527
1.00
15.30
A
C


ATOM
2900
O
GLU
A
189
58.502
−29.345
13.901
1.00
14.88
A
O


ATOM
2902
N
LEU
A
190
59.773
−30.280
12.284
1.00
14.95
A
N


ATOM
2903
CA
LEU
A
190
58.806
−30.145
11.203
1.00
14.48
A
C


ATOM
2905
CB
LEU
A
190
58.730
−28.685
10.740
1.00
14.32
A
C


ATOM
2908
CG
LEU
A
190
57.637
−28.308
9.735
1.00
13.70
A
C


ATOM
2910
CD1
LEU
A
190
56.257
−28.398
10.377
1.00
12.88
A
C


ATOM
2914
CD2
LEU
A
190
57.885
−26.909
9.175
1.00
9.41
A
C


ATOM
2918
C
LEU
A
190
59.281
−31.037
10.057
1.00
14.33
A
C


ATOM
2919
O
LEU
A
190
60.460
−31.011
9.711
1.00
14.00
A
O


ATOM
2921
N
PRO
A
191
58.379
−31.839
9.468
1.00
14.65
A
N


ATOM
2922
CA
PRO
A
191
58.827
−32.779
8.437
1.00
14.74
A
C


ATOM
2924
CB
PRO
A
191
57.674
−33.777
8.358
1.00
14.70
A
C


ATOM
2927
CG
PRO
A
191
56.473
−32.971
8.707
1.00
15.26
A
C


ATOM
2930
CD
PRO
A
191
56.918
−31.887
9.655
1.00
14.91
A
C


ATOM
2933
C
PRO
A
191
59.059
−32.111
7.082
1.00
14.61
A
C


ATOM
2934
O
PRO
A
191
58.725
−30.941
6.903
1.00
15.11
A
O


ATOM
2935
N
LEU
A
192
59.624
−32.860
6.142
1.00
14.26
A
N


ATOM
2936
CA
LEU
A
192
59.935
−32.339
4.814
1.00
13.99
A
C


ATOM
2938
CB
LEU
A
192
60.580
−33.424
3.950
1.00
14.19
A
C


ATOM
2941
CG
LEU
A
192
61.980
−33.866
4.391
1.00
16.27
A
C


ATOM
2943
CD1
LEU
A
192
62.353
−35.200
3.765
1.00
17.03
A
C


ATOM
2947
CD2
LEU
A
192
63.019
−32.803
4.053
1.00
17.29
A
C


ATOM
2951
C
LEU
A
192
58.688
−31.817
4.122
1.00
13.36
A
C


ATOM
2952
O
LEU
A
192
58.662
−30.679
3.661
1.00
13.23
A
O


ATOM
2954
N
HIS
A
193
57.651
−32.649
4.086
1.00
13.28
A
N


ATOM
2955
CA
HIS
A
193
56.421
−32.355
3.343
1.00
13.38
A
C


ATOM
2957
CB
HIS
A
193
55.449
−33.537
3.458
1.00
13.14
A
C


ATOM
2960
CG
HIS
A
193
54.224
−33.402
2.608
1.00
12.08
A
C


ATOM
2961
ND1
HIS
A
193
54.279
−33.279
1.237
1.00
11.82
A
N


ATOM
2963
CE1
HIS
A
193
53.053
−33.178
0.757
1.00
11.83
A
C


ATOM
2965
NE2
HIS
A
193
52.204
−33.235
1.767
1.00
9.95
A
N


ATOM
2967
CD2
HIS
A
193
52.910
−33.375
2.936
1.00
10.22
A
C


ATOM
2969
C
HIS
A
193
55.722
−31.055
3.764
1.00
13.92
A
C


ATOM
2970
O
HIS
A
193
54.964
−30.478
2.979
1.00
13.67
A
O


ATOM
2972
N
ARG
A
194
55.971
−30.598
4.989
1.00
14.56
A
N


ATOM
2973
CA
ARG
A
194
55.393
−29.343
5.475
1.00
15.25
A
C


ATOM
2975
CB
ARG
A
194
54.749
−29.557
6.843
1.00
15.26
A
C


ATOM
2978
CG
ARG
A
194
53.625
−30.571
6.824
1.00
16.11
A
C


ATOM
2981
CD
ARG
A
194
52.888
−30.620
8.150
1.00
18.42
A
C


ATOM
2984
NE
ARG
A
194
51.885
−31.684
8.170
1.00
19.85
A
N


ATOM
2986
CZ
ARG
A
194
51.170
−32.042
9.236
1.00
20.13
A
C


ATOM
2987
NH1
ARG
A
194
51.330
−31.431
10.406
1.00
21.48
A
N


ATOM
2990
NH2
ARG
A
194
50.288
−33.028
9.132
1.00
20.98
A
N


ATOM
2993
C
ARG
A
194
56.392
−28.180
5.542
1.00
15.65
A
C


ATOM
2994
O
ARG
A
194
55.981
−27.029
5.629
1.00
16.13
A
O


ATOM
2996
N
ARG
A
195
57.691
−28.468
5.501
1.00
15.83
A
N


ATOM
2997
CA
ARG
A
195
58.707
−27.416
5.544
1.00
15.92
A
C


ATOM
2999
CB
ARG
A
195
60.047
−27.994
5.992
1.00
16.22
A
C


ATOM
3002
CG
ARG
A
195
61.069
−26.938
6.388
1.00
18.02
A
C


ATOM
3005
CD
ARG
A
195
62.434
−27.540
6.681
1.00
18.19
A
C


ATOM
3008
NE
ARG
A
195
62.382
−28.612
7.672
1.00
19.14
A
N


ATOM
3010
CZ
ARG
A
195
62.233
−28.434
8.984
1.00
21.01
A
C


ATOM
3011
NH1
ARG
A
195
62.104
−27.216
9.507
1.00
20.62
A
N


ATOM
3014
NH2
ARG
A
195
62.212
−29.490
9.788
1.00
22.42
A
N


ATOM
3017
C
ARG
A
195
58.866
−26.768
4.171
1.00
15.95
A
C


ATOM
3018
O
ARG
A
195
58.929
−27.471
3.158
1.00
15.90
A
O


ATOM
3020
N
THR
A
196
58.946
−25.436
4.133
1.00
15.87
A
N


ATOM
3021
CA
THR
A
196
59.146
−24.725
2.866
1.00
15.91
A
C


ATOM
3023
CB
THR
A
196
59.126
−23.183
3.019
1.00
15.61
A
C


ATOM
3025
OG1
THR
A
196
60.106
−22.770
3.979
1.00
15.28
A
O


ATOM
3027
CG2
THR
A
196
57.757
−22.700
3.452
1.00
15.63
A
C


ATOM
3031
C
THR
A
196
60.468
−25.151
2.236
1.00
16.35
A
C


ATOM
3032
O
THR
A
196
61.379
−25.611
2.928
1.00
16.39
A
O


ATOM
3034
N
GLN
A
197
60.562
−24.986
0.922
1.00
16.60
A
N


ATOM
3035
CA
GLN
A
197
61.675
−25.537
0.147
1.00
16.65
A
C


ATOM
3037
CB
GLN
A
197
61.292
−25.578
−1.344
1.00
16.83
A
C


ATOM
3040
CG
GLN
A
197
62.268
−24.945
−2.318
1.00
18.46
A
C


ATOM
3043
CD
GLN
A
197
63.359
−25.875
−2.795
1.00
19.11
A
C


ATOM
3044
OE1
GLN
A
197
64.519
−25.716
−2.426
1.00
18.91
A
O


ATOM
3045
NE2
GLN
A
197
62.997
−26.839
−3.639
1.00
19.88
A
N


ATOM
3048
C
GLN
A
197
63.023
−24.834
0.399
1.00
16.45
A
C


ATOM
3049
O
GLN
A
197
64.073
−25.476
0.344
1.00
16.57
A
O


ATOM
3051
N
ARG
A
198
62.990
−23.535
0.692
1.00
16.22
A
N


ATOM
3052
CA
ARG
A
198
64.219
−22.767
0.939
1.00
15.80
A
C


ATOM
3054
CB
ARG
A
198
63.960
−21.270
0.758
1.00
15.86
A
C


ATOM
3057
CG
ARG
A
198
63.690
−20.856
−0.682
1.00
16.65
A
C


ATOM
3060
CD
ARG
A
198
64.967
−20.804
−1.526
1.00
16.78
A
C


ATOM
3063
NE
ARG
A
198
65.295
−22.072
−2.175
1.00
16.13
A
N


ATOM
3065
CZ
ARG
A
198
66.289
−22.234
−3.048
1.00
18.48
A
C


ATOM
3066
NH1
ARG
A
198
67.067
−21.209
−3.393
1.00
17.78
A
N


ATOM
3069
NH2
ARG
A
198
66.511
−23.431
−3.585
1.00
19.12
A
N


ATOM
3072
C
ARG
A
198
64.819
−23.027
2.324
1.00
15.17
A
C


ATOM
3073
O
ARG
A
198
66.032
−23.193
2.452
1.00
14.96
A
O


ATOM
3075
N
LEU
A
199
63.974
−23.051
3.354
1.00
14.66
A
N


ATOM
3076
CA
LEU
A
199
64.425
−23.342
4.719
1.00
14.28
A
C


ATOM
3078
CB
LEU
A
199
63.290
−23.155
5.738
1.00
14.42
A
C


ATOM
3081
CG
LEU
A
199
62.996
−21.723
6.198
1.00
13.58
A
C


ATOM
3083
CD1
LEU
A
199
64.225
−21.108
6.838
1.00
12.91
A
C


ATOM
3087
CD2
LEU
A
199
61.823
−21.698
7.166
1.00
11.52
A
C


ATOM
3091
C
LEU
A
199
64.973
−24.760
4.820
1.00
13.99
A
C


ATOM
3092
O
LEU
A
199
65.941
−25.007
5.542
1.00
13.43
A
O


ATOM
3094
N
GLU
A
200
64.338
−25.686
4.105
1.00
13.99
A
N


ATOM
3095
CA
GLU
A
200
64.840
−27.052
3.993
1.00
14.04
A
C


ATOM
3097
CB
GLU
A
200
63.833
−27.945
3.254
1.00
14.26
A
C


ATOM
3100
CG
GLU
A
200
64.284
−29.393
3.026
1.00
15.07
A
C


ATOM
3103
CD
GLU
A
200
64.864
−30.053
4.267
1.00
16.59
A
C


ATOM
3104
OE1
GLU
A
200
64.228
−29.992
5.341
1.00
18.96
A
O


ATOM
3105
OE2
GLU
A
200
65.957
−30.646
4.165
1.00
16.21
A
O


ATOM
3106
C
GLU
A
200
66.176
−27.051
3.263
1.00
13.82
A
C


ATOM
3107
O
GLU
A
200
67.090
−27.786
3.640
1.00
14.49
A
O


ATOM
3109
N
ALA
A
201
66.283
−26.220
2.226
1.00
13.15
A
N


ATOM
3110
CA
ALA
A
201
67.510
−26.108
1.437
1.00
12.65
A
C


ATOM
3112
CB
ALA
A
201
67.272
−25.238
0.221
1.00
12.47
A
C


ATOM
3116
C
ALA
A
201
68.696
−25.576
2.249
1.00
12.48
A
C


ATOM
3117
O
ALA
A
201
69.755
−26.200
2.272
1.00
12.06
A
O


ATOM
3119
N
VAL
A
202
68.515
−24.439
2.922
1.00
12.67
A
N


ATOM
3120
CA
VAL
A
202
69.609
−23.801
3.673
1.00
12.57
A
C


ATOM
3122
CB
VAL
A
202
69.196
−22.440
4.277
1.00
12.42
A
C


ATOM
3124
CG1
VAL
A
202
68.324
−22.635
5.506
1.00
12.80
A
C


ATOM
3128
CG2
VAL
A
202
70.426
−21.626
4.635
1.00
12.02
A
C


ATOM
3132
C
VAL
A
202
70.130
−24.682
4.800
1.00
12.80
A
C


ATOM
3133
O
VAL
A
202
71.296
−24.580
5.176
1.00
12.89
A
O


ATOM
3135
N
TRP
A
203
69.261
−25.537
5.336
1.00
13.26
A
N


ATOM
3136
CA
TRP
A
203
69.638
−26.478
6.385
1.00
13.35
A
C


ATOM
3138
CB
TRP
A
203
68.399
−26.965
7.140
1.00
13.36
A
C


ATOM
3141
CG
TRP
A
203
68.720
−27.817
8.329
1.00
12.25
A
C


ATOM
3142
CD1
TRP
A
203
68.960
−27.387
9.601
1.00
12.59
A
C


ATOM
3144
NE1
TRP
A
203
69.219
−28.456
10.421
1.00
11.51
A
N


ATOM
3146
CE2
TRP
A
203
69.152
−29.607
9.683
1.00
10.81
A
C


ATOM
3147
CD2
TRP
A
203
68.837
−29.242
8.358
1.00
11.23
A
C


ATOM
3148
CE3
TRP
A
203
68.706
−30.247
7.393
1.00
12.78
A
C


ATOM
3150
CZ3
TRP
A
203
68.893
−31.567
7.778
1.00
12.64
A
C


ATOM
3152
CH2
TRP
A
203
69.205
−31.897
9.107
1.00
11.26
A
C


ATOM
3154
CZ2
TRP
A
203
69.339
−30.934
10.069
1.00
10.95
A
C


ATOM
3156
C
TRP
A
203
70.379
−27.670
5.795
1.00
13.47
A
C


ATOM
3157
O
TRP
A
203
71.515
−27.954
6.183
1.00
13.39
A
O


ATOM
3159
N
SER
A
204
69.730
−28.355
4.852
1.00
13.61
A
N


ATOM
3160
CA
SER
A
204
70.270
−29.589
4.263
1.00
13.87
A
C


ATOM
3162
CB
SER
A
204
69.323
−30.142
3.194
1.00
13.67
A
C


ATOM
3165
OG
SER
A
204
68.234
−30.819
3.792
1.00
13.52
A
O


ATOM
3167
C
SER
A
204
71.666
−29.407
3.674
1.00
14.22
A
C


ATOM
3168
O
SER
A
204
72.476
−30.333
3.708
1.00
14.33
A
O


ATOM
3170
N
ILE
A
205
71.933
−28.216
3.139
1.00
14.32
A
N


ATOM
3171
CA
ILE
A
205
73.259
−27.852
2.639
1.00
14.23
A
C


ATOM
3173
CB
ILE
A
205
73.234
−26.458
1.967
1.00
14.07
A
C


ATOM
3175
CG1
ILE
A
205
72.473
−26.517
0.643
1.00
13.44
A
C


ATOM
3178
CD1
ILE
A
205
72.074
−25.161
0.117
1.00
12.73
A
C


ATOM
3182
CG2
ILE
A
205
74.647
−25.947
1.718
1.00
15.49
A
C


ATOM
3186
C
ILE
A
205
74.292
−27.845
3.769
1.00
14.47
A
C


ATOM
3187
O
ILE
A
205
75.347
−28.479
3.663
1.00
14.24
A
O


ATOM
3189
N
GLU
A
206
73.975
−27.126
4.846
1.00
14.66
A
N


ATOM
3190
CA
GLU
A
206
74.842
−27.051
6.023
1.00
14.82
A
C


ATOM
3192
CB
GLU
A
206
74.219
−26.131
7.082
1.00
15.15
A
C


ATOM
3195
CG
GLU
A
206
75.064
−25.916
8.346
1.00
16.59
A
C


ATOM
3198
CD
GLU
A
206
76.420
−25.279
8.071
1.00
17.90
A
C


ATOM
3199
OE1
GLU
A
206
76.582
−24.629
7.014
1.00
19.11
A
O


ATOM
3200
OE2
GLU
A
206
77.325
−25.424
8.922
1.00
18.61
A
O


ATOM
3201
C
GLU
A
206
75.094
−28.436
6.616
1.00
14.53
A
C


ATOM
3202
O
GLU
A
206
76.197
−28.730
7.072
1.00
14.36
A
O


ATOM
3204
N
ALA
A
207
74.063
−29.277
6.604
1.00
14.37
A
N


ATOM
3205
CA
ALA
A
207
74.173
−30.655
7.079
1.00
14.14
A
C


ATOM
3207
CB
ALA
A
207
72.785
−31.266
7.234
1.00
14.13
A
C


ATOM
3211
C
ALA
A
207
75.015
−31.514
6.141
1.00
13.78
A
C


ATOM
3212
O
ALA
A
207
75.898
−32.248
6.585
1.00
13.22
A
O


ATOM
3214
N
TYR
A
208
74.733
−31.410
4.845
1.00
13.95
A
N


ATOM
3215
CA
TYR
A
208
75.319
−32.297
3.838
1.00
14.17
A
C


ATOM
3217
CB
TYR
A
208
74.531
−32.189
2.525
1.00
14.20
A
C


ATOM
3220
CG
TYR
A
208
74.881
−33.219
1.471
1.00
13.85
A
C


ATOM
3221
CD1
TYR
A
208
74.401
−34.523
1.557
1.00
15.48
A
C


ATOM
3223
CE1
TYR
A
208
74.710
−35.472
0.583
1.00
15.09
A
C


ATOM
3225
CZ
TYR
A
208
75.500
−35.115
−0.494
1.00
13.90
A
C


ATOM
3226
OH
TYR
A
208
75.811
−36.045
−1.458
1.00
11.21
A
O


ATOM
3228
CE2
TYR
A
208
75.984
−33.823
−0.604
1.00
14.12
A
C


ATOM
3230
CD2
TYR
A
208
75.670
−32.882
0.375
1.00
13.38
A
C


ATOM
3232
C
TYR
A
208
76.804
−32.031
3.588
1.00
14.31
A
C


ATOM
3233
O
TYR
A
208
77.515
−32.918
3.120
1.00
14.93
A
O


ATOM
3235
N
ARG
A
209
77.276
−30.825
3.892
1.00
14.14
A
N


ATOM
3236
CA
ARG
A
209
78.691
−30.508
3.698
1.00
14.20
A
C


ATOM
3238
CB
ARG
A
209
78.912
−28.994
3.580
1.00
14.05
A
C


ATOM
3241
CG
ARG
A
209
78.753
−28.202
4.872
1.00
14.18
A
C


ATOM
3244
CD
ARG
A
209
79.424
−26.841
4.766
1.00
14.24
A
C


ATOM
3247
NE
ARG
A
209
78.659
−25.905
3.944
1.00
13.50
A
N


ATOM
3249
CZ
ARG
A
209
79.136
−24.767
3.440
1.00
12.08
A
C


ATOM
3250
NH1
ARG
A
209
80.397
−24.399
3.650
1.00
10.79
A
N


ATOM
3253
NH2
ARG
A
209
78.343
−23.991
2.710
1.00
12.81
A
N


ATOM
3256
C
ARG
A
209
79.571
−31.108
4.802
1.00
14.55
A
C


ATOM
3257
O
ARG
A
209
80.767
−31.309
4.600
1.00
14.80
A
O


ATOM
3259
N
LYS
A
210
78.977
−31.388
5.960
1.00
15.15
A
N


ATOM
3260
CA
LYS
A
210
79.694
−32.011
7.076
1.00
15.61
A
C


ATOM
3262
CB
LYS
A
210
79.018
−31.669
8.406
1.00
15.61
A
C


ATOM
3265
CG
LYS
A
210
78.981
−30.177
8.719
1.00
15.58
A
C


ATOM
3268
CD
LYS
A
210
78.026
−29.867
9.865
1.00
15.71
A
C


ATOM
3271
CE
LYS
A
210
77.856
−28.368
10.057
1.00
15.97
A
C


ATOM
3274
NZ
LYS
A
210
76.875
−28.038
11.131
1.00
15.56
A
N


ATOM
3278
C
LYS
A
210
79.795
−33.531
6.911
1.00
16.30
A
C


ATOM
3279
O
LYS
A
210
80.599
−34.176
7.584
1.00
16.27
A
O


ATOM
3281
N
LYS
A
211
78.972
−34.104
6.033
1.00
17.15
A
N


ATOM
3282
CA
LYS
A
211
79.141
−35.496
5.628
1.00
17.96
A
C


ATOM
3284
CB
LYS
A
211
78.049
−35.934
4.644
1.00
18.23
A
C


ATOM
3287
CG
LYS
A
211
76.694
−36.253
5.260
1.00
19.44
A
C


ATOM
3290
CD
LYS
A
211
75.846
−37.071
4.282
1.00
21.73
A
C


ATOM
3293
CE
LYS
A
211
74.424
−37.282
4.784
1.00
23.25
A
C


ATOM
3296
NZ
LYS
A
211
74.388
−38.036
6.071
1.00
24.71
A
N


ATOM
3300
C
LYS
A
211
80.499
−35.635
4.952
1.00
18.46
A
C


ATOM
3301
O
LYS
A
211
80.739
−35.015
3.915
1.00
18.58
A
O


ATOM
3303
N
GLU
A
212
81.383
−36.442
5.534
1.00
19.08
A
N


ATOM
3304
CA
GLU
A
212
82.726
−36.640
4.975
1.00
19.70
A
C


ATOM
3306
CB
GLU
A
212
83.607
−37.453
5.936
1.00
20.07
A
C


ATOM
3309
CG
GLU
A
212
85.113
−37.304
5.683
1.00
20.44
A
C


ATOM
3312
CD
GLU
A
212
85.953
−38.339
6.423
1.00
20.22
A
C


ATOM
3313
OE1
GLU
A
212
86.981
−37.951
7.016
1.00
19.88
A
O


ATOM
3314
OE2
GLU
A
212
85.595
−39.538
6.407
1.00
18.93
A
O


ATOM
3315
C
GLU
A
212
82.667
−37.328
3.606
1.00
19.59
A
C


ATOM
3316
O
GLU
A
212
83.540
−37.119
2.763
1.00
19.49
A
O


ATOM
3318
N
ASP
A
213
81.627
−38.133
3.393
1.00
19.59
A
N


ATOM
3319
CA
ASP
A
213
81.420
−38.841
2.128
1.00
19.85
A
C


ATOM
3321
CB
ASP
A
213
80.904
−40.262
2.404
1.00
20.37
A
C


ATOM
3324
CG
ASP
A
213
79.566
−40.272
3.132
1.00
22.19
A
C


ATOM
3325
OD1
ASP
A
213
79.448
−39.595
4.178
1.00
23.92
A
O


ATOM
3326
OD2
ASP
A
213
78.636
−40.959
2.660
1.00
25.96
A
O


ATOM
3327
C
ASP
A
213
80.452
−38.100
1.194
1.00
19.34
A
C


ATOM
3328
O
ASP
A
213
79.764
−38.723
0.383
1.00
19.04
A
O


ATOM
3330
N
ALA
A
214
80.412
−36.773
1.299
1.00
19.11
A
N


ATOM
3331
CA
ALA
A
214
79.501
−35.959
0.496
1.00
19.01
A
C


ATOM
3333
CB
ALA
A
214
79.366
−34.570
1.099
1.00
18.73
A
C


ATOM
3337
C
ALA
A
214
79.984
−35.857
−0.946
1.00
19.16
A
C


ATOM
3338
O
ALA
A
214
81.188
−35.779
−1.198
1.00
19.39
A
O


ATOM
3340
N
ASN
A
215
79.040
−35.860
−1.885
1.00
19.33
A
N


ATOM
3341
CA
ASN
A
215
79.354
−35.675
−3.302
1.00
19.51
A
C


ATOM
3343
CB
ASN
A
215
78.184
−36.142
−4.182
1.00
19.77
A
C


ATOM
3346
CG
ASN
A
215
78.595
−36.396
−5.628
1.00
20.67
A
C


ATOM
3347
OD1
ASN
A
215
78.874
−35.463
−6.383
1.00
22.18
A
O


ATOM
3348
ND2
ASN
A
215
78.623
−37.666
−6.019
1.00
20.55
A
N


ATOM
3351
C
ASN
A
215
79.683
−34.202
−3.564
1.00
19.05
A
C


ATOM
3352
O
ASN
A
215
78.819
−33.333
−3.428
1.00
19.14
A
O


ATOM
3354
N
GLN
A
216
80.934
−33.932
−3.932
1.00
18.33
A
N


ATOM
3355
CA
GLN
A
216
81.424
−32.558
−4.070
1.00
17.80
A
C


ATOM
3357
CB
GLN
A
216
82.943
−32.536
−4.292
1.00
17.98
A
C


ATOM
3360
CG
GLN
A
216
83.771
−33.244
−3.213
1.00
19.00
A
C


ATOM
3363
CD
GLN
A
216
83.465
−32.763
−1.804
1.00
19.26
A
C


ATOM
3364
OE1
GLN
A
216
83.323
−31.565
−1.560
1.00
18.93
A
O


ATOM
3365
NE2
GLN
A
216
83.369
−33.701
−0.868
1.00
19.47
A
N


ATOM
3368
C
GLN
A
216
80.735
−31.814
−5.208
1.00
17.08
A
C


ATOM
3369
O
GLN
A
216
80.432
−30.627
−5.080
1.00
17.09
A
O


ATOM
3371
N
VAL
A
217
80.490
−32.511
−6.315
1.00
16.33
A
N


ATOM
3372
CA
VAL
A
217
79.826
−31.912
−7.474
1.00
15.80
A
C


ATOM
3374
CB
VAL
A
217
79.755
−32.894
−8.668
1.00
15.84
A
C


ATOM
3376
CG1
VAL
A
217
78.935
−32.298
−9.809
1.00
14.63
A
C


ATOM
3380
CG2
VAL
A
217
81.155
−33.254
−9.147
1.00
16.01
A
C


ATOM
3384
C
VAL
A
217
78.411
−31.454
−7.123
1.00
15.46
A
C


ATOM
3385
O
VAL
A
217
77.999
−30.355
−7.500
1.00
15.60
A
O


ATOM
3387
N
LEU
A
218
77.680
−32.296
−6.395
1.00
14.90
A
N


ATOM
3388
CA
LEU
A
218
76.300
−31.998
−6.009
1.00
14.22
A
C


ATOM
3390
CB
LEU
A
218
75.629
−33.247
−5.428
1.00
13.96
A
C


ATOM
3393
CG
LEU
A
218
74.139
−33.142
−5.094
1.00
13.06
A
C


ATOM
3395
CD1
LEU
A
218
73.337
−32.809
−6.334
1.00
12.25
A
C


ATOM
3399
CD2
LEU
A
218
73.641
−34.437
−4.469
1.00
13.26
A
C


ATOM
3403
C
LEU
A
218
76.223
−30.849
−5.003
1.00
14.10
A
C


ATOM
3404
O
LEU
A
218
75.312
−30.020
−5.072
1.00
14.58
A
O


ATOM
3406
N
LEU
A
219
77.176
−30.810
−4.071
1.00
13.33
A
N


ATOM
3407
CA
LEU
A
219
77.232
−29.759
−3.054
1.00
12.42
A
C


ATOM
3409
CB
LEU
A
219
78.290
−30.088
−1.996
1.00
12.57
A
C


ATOM
3412
CG
LEU
A
219
78.579
−29.028
−0.926
1.00
12.20
A
C


ATOM
3414
CD1
LEU
A
219
77.303
−28.587
−0.229
1.00
11.68
A
C


ATOM
3418
CD2
LEU
A
219
79.581
−29.562
0.083
1.00
11.55
A
C


ATOM
3422
C
LEU
A
219
77.548
−28.415
−3.687
1.00
11.77
A
C


ATOM
3423
O
LEU
A
219
76.797
−27.456
−3.523
1.00
11.68
A
O


ATOM
3425
N
GLU
A
220
78.664
−28.358
−4.411
1.00
11.19
A
N


ATOM
3426
CA
GLU
A
220
79.099
−27.132
−5.084
1.00
10.73
A
C


ATOM
3428
CB
GLU
A
220
80.281
−27.414
−6.019
1.00
10.70
A
C


ATOM
3431
CG
GLU
A
220
80.927
−26.162
−6.616
1.00
11.19
A
C


ATOM
3434
CD
GLU
A
220
82.256
−26.444
−7.314
1.00
12.55
A
C


ATOM
3435
OE1
GLU
A
220
82.631
−27.630
−7.453
1.00
13.13
A
O


ATOM
3436
OE2
GLU
A
220
82.929
−25.473
−7.724
1.00
12.14
A
O


ATOM
3437
C
GLU
A
220
77.950
−26.501
−5.862
1.00
10.27
A
C


ATOM
3438
O
GLU
A
220
77.748
−25.292
−5.793
1.00
10.52
A
O


ATOM
3440
N
LEU
A
221
77.194
−27.325
−6.584
1.00
9.55
A
N


ATOM
3441
CA
LEU
A
221
76.018
−26.851
−7.310
1.00
9.02
A
C


ATOM
3443
CB
LEU
A
221
75.442
−27.966
−8.186
1.00
8.70
A
C


ATOM
3446
CG
LEU
A
221
74.258
−27.599
−9.086
1.00
7.05
A
C


ATOM
3448
CD1
LEU
A
221
74.630
−26.491
−10.059
1.00
2.00
A
C


ATOM
3452
CD2
LEU
A
221
73.772
−28.833
−9.831
1.00
6.26
A
C


ATOM
3456
C
LEU
A
221
74.948
−26.343
−6.347
1.00
9.08
A
C


ATOM
3457
O
LEU
A
221
74.395
−25.262
−6.544
1.00
8.80
A
O


ATOM
3459
N
ALA
A
222
74.669
−27.124
−5.305
1.00
9.46
A
N


ATOM
3460
CA
ALA
A
222
73.666
−26.757
−4.301
1.00
9.95
A
C


ATOM
3462
CB
ALA
A
222
73.633
−27.794
−3.181
1.00
9.71
A
C


ATOM
3466
C
ALA
A
222
73.913
−25.358
−3.728
1.00
10.24
A
C


ATOM
3467
O
ALA
A
222
72.979
−24.572
−3.572
1.00
10.55
A
O


ATOM
3469
N
ILE
A
223
75.173
−25.055
−3.430
1.00
10.52
A
N


ATOM
3470
CA
ILE
A
223
75.562
−23.737
−2.925
1.00
10.83
A
C


ATOM
3472
CB
ILE
A
223
77.049
−23.711
−2.476
1.00
10.98
A
C


ATOM
3474
CG1
ILE
A
223
77.305
−24.712
−1.345
1.00
11.58
A
C


ATOM
3477
CD1
ILE
A
223
78.778
−24.910
−1.045
1.00
12.62
A
C


ATOM
3481
CG2
ILE
A
223
77.451
−22.315
−2.019
1.00
9.71
A
C


ATOM
3485
C
ILE
A
223
75.374
−22.683
−4.016
1.00
11.05
A
C


ATOM
3486
O
ILE
A
223
74.722
−21.656
−3.800
1.00
10.83
A
O


ATOM
3488
N
LEU
A
224
75.955
−22.958
−5.183
1.00
11.18
A
N


ATOM
3489
CA
LEU
A
224
75.918
−22.044
−6.328
1.00
11.07
A
C


ATOM
3491
CB
LEU
A
224
76.648
−22.654
−7.534
1.00
11.14
A
C


ATOM
3494
CG
LEU
A
224
78.143
−22.340
−7.658
1.00
11.66
A
C


ATOM
3496
CD1
LEU
A
224
78.746
−23.108
−8.827
1.00
11.34
A
C


ATOM
3500
CD2
LEU
A
224
78.905
−22.632
−6.369
1.00
11.95
A
C


ATOM
3504
C
LEU
A
224
74.500
−21.660
−6.730
1.00
10.85
A
C


ATOM
3505
O
LEU
A
224
74.239
−20.497
−7.035
1.00
10.84
A
O


ATOM
3507
N
ASP
A
225
73.593
−22.635
−6.727
1.00
10.80
A
N


ATOM
3508
CA
ASP
A
225
72.207
−22.395
−7.125
1.00
10.89
A
C


ATOM
3510
CB
ASP
A
225
71.505
−23.705
−7.481
1.00
10.48
A
C


ATOM
3513
CG
ASP
A
225
70.158
−23.481
−8.142
1.00
9.49
A
C


ATOM
3514
OD1
ASP
A
225
69.184
−23.189
−7.422
1.00
10.17
A
O


ATOM
3515
OD2
ASP
A
225
70.069
−23.597
−9.382
1.00
8.04
A
O


ATOM
3516
C
ASP
A
225
71.416
−21.659
−6.047
1.00
11.49
A
C


ATOM
3517
O
ASP
A
225
70.605
−20.792
−6.367
1.00
11.55
A
O


ATOM
3519
N
TYR
A
226
71.641
−22.004
−4.780
1.00
12.19
A
N


ATOM
3520
CA
TYR
A
226
70.963
−21.320
−3.676
1.00
12.94
A
C


ATOM
3522
CB
TYR
A
226
71.215
−22.022
−2.335
1.00
13.18
A
C


ATOM
3525
CG
TYR
A
226
70.495
−21.360
−1.178
1.00
13.58
A
C


ATOM
3526
CD1
TYR
A
226
69.207
−21.745
−0.825
1.00
15.76
A
C


ATOM
3528
CE1
TYR
A
226
68.536
−21.133
0.227
1.00
17.41
A
C


ATOM
3530
CZ
TYR
A
226
69.154
−20.117
0.932
1.00
18.41
A
C


ATOM
3531
OH
TYR
A
226
68.493
−19.509
1.972
1.00
18.87
A
O


ATOM
3533
CE2
TYR
A
226
70.434
−19.712
0.595
1.00
16.75
A
C


ATOM
3535
CD2
TYR
A
226
71.093
−20.331
−0.457
1.00
14.36
A
C


ATOM
3537
C
TYR
A
226
71.394
−19.855
−3.582
1.00
13.23
A
C


ATOM
3538
O
TYR
A
226
70.562
−18.971
−3.355
1.00
13.29
A
O


ATOM
3540
N
ASN
A
227
72.692
−19.608
−3.742
1.00
13.39
A
N


ATOM
3541
CA
ASN
A
227
73.221
−18.246
−3.718
1.00
14.03
A
C


ATOM
3543
CB
ASN
A
227
74.751
−18.258
−3.625
1.00
14.09
A
C


ATOM
3546
CG
ASN
A
227
75.255
−18.679
−2.250
1.00
14.19
A
C


ATOM
3547
OD1
ASN
A
227
74.571
−18.512
−1.241
1.00
14.72
A
O


ATOM
3548
ND2
ASN
A
227
76.467
−19.217
−2.208
1.00
15.25
A
N


ATOM
3551
C
ASN
A
227
72.768
−17.429
−4.929
1.00
14.55
A
C


ATOM
3552
O
ASN
A
227
72.560
−16.219
−4.819
1.00
14.82
A
O


ATOM
3554
N
MET
A
228
72.619
−18.093
−6.074
1.00
14.98
A
N


ATOM
3555
CA
MET
A
228
72.085
−17.462
−7.284
1.00
15.29
A
C


ATOM
3557
CB
MET
A
228
72.127
−18.444
−8.462
1.00
15.61
A
C


ATOM
3560
CG
MET
A
228
71.507
−17.933
−9.767
1.00
16.18
A
C


ATOM
3563
SD
MET
A
228
70.987
−19.279
−10.861
1.00
18.75
A
S


ATOM
3564
CE
MET
A
228
69.510
−19.868
−10.029
1.00
17.19
A
C


ATOM
3568
C
MET
A
228
70.650
−17.009
−7.049
1.00
15.29
A
C


ATOM
3569
O
MET
A
228
70.329
−15.833
−7.218
1.00
15.27
A
O


ATOM
3571
N
ILE
A
229
69.793
−17.951
−6.661
1.00
15.43
A
N


ATOM
3572
CA
ILE
A
229
68.385
−17.655
−6.413
1.00
15.53
A
C


ATOM
3574
CB
ILE
A
229
67.605
−18.896
−5.916
1.00
15.48
A
C


ATOM
3576
CG1
ILE
A
229
67.419
−19.909
−7.051
1.00
15.09
A
C


ATOM
3579
CD1
ILE
A
229
66.660
−21.167
−6.643
1.00
11.04
A
C


ATOM
3583
CG2
ILE
A
229
66.240
−18.489
−5.384
1.00
16.76
A
C


ATOM
3587
C
ILE
A
229
68.252
−16.529
−5.395
1.00
15.81
A
C


ATOM
3588
O
ILE
A
229
67.429
−15.634
−5.566
1.00
16.48
A
O


ATOM
3590
N
GLN
A
230
69.073
−16.567
−4.348
1.00
15.87
A
N


ATOM
3591
CA
GLN
A
230
69.059
−15.514
−3.332
1.00
15.81
A
C


ATOM
3593
CB
GLN
A
230
70.046
−15.817
−2.199
1.00
15.91
A
C


ATOM
3596
CG
GLN
A
230
69.925
−14.855
−1.019
1.00
15.74
A
C


ATOM
3599
CD
GLN
A
230
70.996
−15.064
0.026
1.00
15.63
A
C


ATOM
3600
OE1
GLN
A
230
71.920
−14.261
0.147
1.00
17.47
A
O


ATOM
3601
NE2
GLN
A
230
70.879
−16.145
0.791
1.00
14.80
A
N


ATOM
3604
C
GLN
A
230
69.372
−14.143
−3.929
1.00
15.64
A
C


ATOM
3605
O
GLN
A
230
68.772
−13.147
−3.532
1.00
15.71
A
O


ATOM
3607
N
SER
A
231
70.305
−14.091
−4.878
1.00
15.55
A
N


ATOM
3608
CA
SER
A
231
70.678
−12.819
−5.504
1.00
15.35
A
C


ATOM
3610
CB
SER
A
231
71.927
−12.962
−6.385
1.00
15.10
A
C


ATOM
3613
OG
SER
A
231
71.603
−13.433
−7.681
1.00
15.04
A
O


ATOM
3615
C
SER
A
231
69.511
−12.251
−6.308
1.00
15.24
A
C


ATOM
3616
O
SER
A
231
69.441
−11.041
−6.525
1.00
15.43
A
O


ATOM
3618
N
VAL
A
232
68.605
−13.126
−6.747
1.00
15.03
A
N


ATOM
3619
CA
VAL
A
232
67.343
−12.692
−7.341
1.00
15.37
A
C


ATOM
3621
CB
VAL
A
232
66.631
−13.837
−8.091
1.00
15.43
A
C


ATOM
3623
CG1
VAL
A
232
65.234
−13.406
−8.544
1.00
14.95
A
C


ATOM
3627
CG2
VAL
A
232
67.468
−14.282
−9.277
1.00
15.59
A
C


ATOM
3631
C
VAL
A
232
66.427
−12.130
−6.256
1.00
15.65
A
C


ATOM
3632
O
VAL
A
232
65.897
−11.027
−6.401
1.00
15.40
A
O


ATOM
3634
N
TYR
A
233
66.259
−12.882
−5.168
1.00
16.13
A
N


ATOM
3635
CA
TYR
A
233
65.453
−12.426
−4.030
1.00
16.89
A
C


ATOM
3637
CB
TYR
A
233
65.588
−13.370
−2.825
1.00
16.70
A
C


ATOM
3640
CG
TYR
A
233
65.023
−14.766
−2.995
1.00
16.10
A
C


ATOM
3641
CD1
TYR
A
233
64.102
−15.068
−4.001
1.00
17.42
A
C


ATOM
3643
CE1
TYR
A
233
63.584
−16.348
−4.137
1.00
16.75
A
C


ATOM
3645
CZ
TYR
A
233
63.969
−17.336
−3.253
1.00
16.03
A
C


ATOM
3646
OH
TYR
A
233
63.452
−18.601
−3.388
1.00
17.62
A
O


ATOM
3648
CE2
TYR
A
233
64.868
−17.060
−2.241
1.00
14.85
A
C


ATOM
3650
CD2
TYR
A
233
65.385
−15.782
−2.115
1.00
14.89
A
C


ATOM
3652
C
TYR
A
233
65.841
−11.016
−3.591
1.00
17.81
A
C


ATOM
3653
O
TYR
A
233
64.977
−10.199
−3.267
1.00
17.90
A
O


ATOM
3655
N
GLN
A
234
67.142
−10.743
−3.577
1.00
19.03
A
N


ATOM
3656
CA
GLN
A
234
67.656
−9.424
−3.212
1.00
20.11
A
C


ATOM
3658
CB
GLN
A
234
69.178
−9.474
−3.026
1.00
20.14
A
C


ATOM
3661
CG
GLN
A
234
69.614
−10.305
−1.821
1.00
20.32
A
C


ATOM
3664
CD
GLN
A
234
71.113
−10.522
−1.755
1.00
20.42
A
C


ATOM
3665
OE1
GLN
A
234
71.897
−9.618
−2.046
1.00
21.90
A
O


ATOM
3666
NE2
GLN
A
234
71.519
−11.725
−1.359
1.00
19.04
A
N


ATOM
3669
C
GLN
A
234
67.273
−8.370
−4.251
1.00
20.93
A
C


ATOM
3670
O
GLN
A
234
66.878
−7.258
−3.890
1.00
20.70
A
O


ATOM
3672
N
ARG
A
235
67.380
−8.728
−5.533
1.00
21.91
A
N


ATOM
3673
CA
ARG
A
235
66.999
−7.828
−6.629
1.00
22.67
A
C


ATOM
3675
CB
ARG
A
235
67.476
−8.369
−7.989
1.00
23.14
A
C


ATOM
3678
CG
ARG
A
235
67.224
−7.413
−9.167
1.00
24.55
A
C


ATOM
3681
CD
ARG
A
235
68.367
−7.390
−10.199
1.00
27.72
A
C


ATOM
3684
NE
ARG
A
235
68.169
−8.321
−11.317
1.00
30.54
A
N


ATOM
3686
CZ
ARG
A
235
68.777
−9.502
−11.474
1.00
31.20
A
C


ATOM
3687
NH1
ARG
A
235
69.652
−9.961
−10.582
1.00
31.84
A
N


ATOM
3690
NH2
ARG
A
235
68.502
−10.239
−12.547
1.00
30.15
A
N


ATOM
3693
C
ARG
A
235
65.489
−7.586
−6.647
1.00
22.58
A
C


ATOM
3694
O
ARG
A
235
65.041
−6.485
−6.977
1.00
22.79
A
O


ATOM
3696
N
ASP
A
236
64.714
−8.613
−6.298
1.00
22.21
A
N


ATOM
3697
CA
ASP
A
236
63.264
−8.470
−6.137
1.00
22.10
A
C


ATOM
3699
CB
ASP
A
236
62.602
−9.827
−5.858
1.00
21.87
A
C


ATOM
3702
CG
ASP
A
236
62.525
−10.721
−7.087
1.00
21.53
A
C


ATOM
3703
OD1
ASP
A
236
62.684
−10.224
−8.222
1.00
19.56
A
O


ATOM
3704
OD2
ASP
A
236
62.293
−11.936
−6.907
1.00
20.26
A
O


ATOM
3705
C
ASP
A
236
62.926
−7.513
−4.995
1.00
22.23
A
C


ATOM
3706
O
ASP
A
236
61.997
−6.712
−5.107
1.00
22.26
A
O


ATOM
3708
N
LEU
A
237
63.686
−7.598
−3.902
1.00
22.39
A
N


ATOM
3709
CA
LEU
A
237
63.391
−6.829
−2.693
1.00
22.41
A
C


ATOM
3711
CB
LEU
A
237
64.157
−7.387
−1.489
1.00
22.11
A
C


ATOM
3714
CG
LEU
A
237
63.678
−6.902
−0.118
1.00
21.18
A
C


ATOM
3716
CD1
LEU
A
237
62.211
−7.251
0.103
1.00
20.99
A
C


ATOM
3720
CD2
LEU
A
237
64.532
−7.497
0.986
1.00
20.81
A
C


ATOM
3724
C
LEU
A
237
63.701
−5.347
−2.860
1.00
22.97
A
C


ATOM
3725
O
LEU
A
237
62.888
−4.503
−2.487
1.00
23.24
A
O


ATOM
3727
N
ARG
A
238
64.870
−5.032
−3.414
1.00
23.56
A
N


ATOM
3728
CA
ARG
A
238
65.252
−3.637
−3.655
1.00
23.85
A
C


ATOM
3730
CB
ARG
A
238
66.594
−3.544
−4.391
1.00
23.60
A
C


ATOM
3733
CG
ARG
A
238
67.798
−3.930
−3.546
1.00
23.92
A
C


ATOM
3736
CD
ARG
A
238
69.109
−3.464
−4.176
1.00
25.61
A
C


ATOM
3739
NE
ARG
A
238
69.289
−3.951
−5.547
1.00
26.87
A
N


ATOM
3741
CZ
ARG
A
238
69.725
−5.168
−5.887
1.00
27.26
A
C


ATOM
3742
NH1
ARG
A
238
70.036
−6.073
−4.961
1.00
27.13
A
N


ATOM
3745
NH2
ARG
A
238
69.847
−5.487
−7.172
1.00
26.94
A
N


ATOM
3748
C
ARG
A
238
64.169
−2.900
−4.446
1.00
24.35
A
C


ATOM
3749
O
ARG
A
238
63.854
−1.750
−4.142
1.00
24.59
A
O


ATOM
3751
N
GLU
A
239
63.600
−3.575
−5.445
1.00
24.73
A
N


ATOM
3752
CA
GLU
A
239
62.514
−3.020
−6.259
1.00
25.20
A
C


ATOM
3754
CB
GLU
A
239
62.197
−3.957
−7.431
1.00
25.81
A
C


ATOM
3757
CG
GLU
A
239
61.161
−3.414
−8.425
1.00
28.50
A
C


ATOM
3760
CD
GLU
A
239
60.814
−4.406
−9.530
1.00
31.93
A
C


ATOM
3761
OE1
GLU
A
239
61.344
−5.542
−9.512
1.00
33.54
A
O


ATOM
3762
OE2
GLU
A
239
60.005
−4.048
−10.417
1.00
33.16
A
O


ATOM
3763
C
GLU
A
239
61.254
−2.791
−5.423
1.00
24.67
A
C


ATOM
3764
O
GLU
A
239
60.556
−1.788
−5.596
1.00
24.49
A
O


ATOM
3766
N
THR
A
240
60.966
−3.730
−4.528
1.00
24.08
A
N


ATOM
3767
CA
THR
A
240
59.829
−3.610
−3.624
1.00
23.83
A
C


ATOM
3769
CB
THR
A
240
59.535
−4.946
−2.915
1.00
23.90
A
C


ATOM
3771
OG1
THR
A
240
59.679
−6.026
−3.845
1.00
24.05
A
O


ATOM
3773
CG2
THR
A
240
58.121
−4.953
−2.344
1.00
24.20
A
C


ATOM
3777
C
THR
A
240
60.089
−2.524
−2.578
1.00
23.67
A
C


ATOM
3778
O
THR
A
240
59.225
−1.686
−2.318
1.00
23.85
A
O


ATOM
3780
N
SER
A
241
61.284
−2.541
−1.990
1.00
23.37
A
N


ATOM
3781
CA
SER
A
241
61.684
−1.535
−1.003
1.00
23.30
A
C


ATOM
3783
CB
SER
A
241
63.097
−1.811
−0.495
1.00
23.25
A
C


ATOM
3786
OG
SER
A
241
63.136
−3.010
0.253
1.00
24.21
A
O


ATOM
3788
C
SER
A
241
61.612
−0.117
−1.561
1.00
23.34
A
C


ATOM
3789
O
SER
A
241
61.297
0.820
−0.831
1.00
23.53
A
O


ATOM
3791
N
ARG
A
242
61.912
0.040
−2.847
1.00
23.51
A
N


ATOM
3792
CA
ARG
A
242
61.754
1.334
−3.509
1.00
23.66
A
C


ATOM
3794
CB
ARG
A
242
62.312
1.304
−4.941
1.00
23.94
A
C


ATOM
3797
CG
ARG
A
242
63.841
1.370
−5.019
1.00
24.87
A
C


ATOM
3800
CD
ARG
A
242
64.335
1.973
−6.333
1.00
26.38
A
C


ATOM
3803
NE
ARG
A
242
64.074
1.116
−7.492
1.00
28.02
A
N


ATOM
3805
CZ
ARG
A
242
64.802
0.054
−7.848
1.00
27.68
A
C


ATOM
3806
NH1
ARG
A
242
64.462
−0.643
−8.928
1.00
26.86
A
N


ATOM
3809
NH2
ARG
A
242
65.861
−0.324
−7.135
1.00
27.49
A
N


ATOM
3812
C
ARG
A
242
60.286
1.757
−3.514
1.00
23.31
A
C


ATOM
3813
O
ARG
A
242
59.976
2.920
−3.264
1.00
23.30
A
O


ATOM
3815
N
TRP
A
243
59.393
0.809
−3.788
1.00
23.18
A
N


ATOM
3816
CA
TRP
A
243
57.949
1.072
−3.768
1.00
23.23
A
C


ATOM
3818
CB
TRP
A
243
57.177
−0.111
−4.369
1.00
23.16
A
C


ATOM
3821
CG
TRP
A
243
55.704
−0.106
−4.072
1.00
23.21
A
C


ATOM
3822
CD1
TRP
A
243
54.729
0.555
−4.762
1.00
23.71
A
C


ATOM
3824
NE1
TRP
A
243
53.499
0.317
−4.193
1.00
23.58
A
N


ATOM
3826
CE2
TRP
A
243
53.662
−0.514
−3.116
1.00
23.23
A
C


ATOM
3827
CD2
TRP
A
243
55.041
−0.802
−3.009
1.00
23.80
A
C


ATOM
3828
CE3
TRP
A
243
55.478
−1.639
−1.973
1.00
23.02
A
C


ATOM
3830
CZ3
TRP
A
243
54.535
−2.156
−1.091
1.00
22.08
A
C


ATOM
3832
CH2
TRP
A
243
53.171
−1.849
−1.224
1.00
21.07
A
C


ATOM
3834
CZ2
TRP
A
243
52.717
−1.033
−2.228
1.00
22.30
A
C


ATOM
3836
C
TRP
A
243
57.440
1.364
−2.353
1.00
23.29
A
C


ATOM
3837
O
TRP
A
243
56.706
2.332
−2.139
1.00
23.34
A
O


ATOM
3839
N
TRP
A
244
57.830
0.522
−1.399
1.00
23.09
A
N


ATOM
3840
CA
TRP
A
244
57.355
0.641
−0.019
1.00
22.81
A
C


ATOM
3842
CB
TRP
A
244
57.907
−0.507
0.834
1.00
22.28
A
C


ATOM
3845
CG
TRP
A
244
57.373
−0.551
2.242
1.00
21.81
A
C


ATOM
3846
CD1
TRP
A
244
58.102
−0.486
3.393
1.00
22.74
A
C


ATOM
3848
NE1
TRP
A
244
57.271
−0.556
4.486
1.00
22.22
A
N


ATOM
3850
CE2
TRP
A
244
55.976
−0.667
4.055
1.00
21.12
A
C


ATOM
3851
CD2
TRP
A
244
56.000
−0.666
2.645
1.00
20.57
A
C


ATOM
3852
CE3
TRP
A
244
54.789
−0.766
1.951
1.00
19.76
A
C


ATOM
3854
CZ3
TRP
A
244
53.610
−0.863
2.675
1.00
19.15
A
C


ATOM
3856
CH2
TRP
A
244
53.619
−0.863
4.076
1.00
20.39
A
C


ATOM
3858
CZ2
TRP
A
244
54.789
−0.764
4.784
1.00
21.06
A
C


ATOM
3860
C
TRP
A
244
57.699
1.996
0.608
1.00
23.07
A
C


ATOM
3861
O
TRP
A
244
56.851
2.609
1.256
1.00
23.27
A
O


ATOM
3863
N
ARG
A
245
58.930
2.467
0.408
1.00
23.23
A
N


ATOM
3864
CA
ARG
A
245
59.342
3.773
0.934
1.00
23.46
A
C


ATOM
3866
CB
ARG
A
245
60.839
4.028
0.708
1.00
23.77
A
C


ATOM
3869
CG
ARG
A
245
61.769
3.206
1.596
1.00
25.08
A
C


ATOM
3872
CD
ARG
A
245
63.090
3.929
1.866
1.00
28.31
A
C


ATOM
3875
NE
ARG
A
245
63.649
4.582
0.677
1.00
30.86
A
N


ATOM
3877
CZ
ARG
A
245
64.296
3.963
−0.312
1.00
32.93
A
C


ATOM
3878
NH1
ARG
A
245
64.480
2.644
−0.296
1.00
33.65
A
N


ATOM
3881
NH2
ARG
A
245
64.760
4.671
−1.338
1.00
33.03
A
N


ATOM
3884
C
ARG
A
245
58.532
4.898
0.295
1.00
23.19
A
C


ATOM
3885
O
ARG
A
245
58.020
5.776
0.994
1.00
23.26
A
O


ATOM
3887
N
ARG
A
246
58.426
4.860
−1.032
1.00
22.85
A
N


ATOM
3888
CA
ARG
A
246
57.653
5.843
−1.799
1.00
22.73
A
C


ATOM
3890
CB
ARG
A
246
57.613
5.451
−3.282
1.00
23.21
A
C


ATOM
3893
CG
ARG
A
246
58.727
6.068
−4.126
1.00
26.50
A
C


ATOM
3896
CD
ARG
A
246
58.216
7.252
−4.944
1.00
30.69
A
C


ATOM
3899
NE
ARG
A
246
57.435
6.800
−6.098
1.00
33.43
A
N


ATOM
3901
CZ
ARG
A
246
57.944
6.440
−7.278
1.00
35.34
A
C


ATOM
3902
NH1
ARG
A
246
59.257
6.479
−7.505
1.00
35.77
A
N


ATOM
3905
NH2
ARG
A
246
57.129
6.038
−8.249
1.00
35.70
A
N


ATOM
3908
C
ARG
A
246
56.232
5.997
−1.266
1.00
21.79
A
C


ATOM
3909
O
ARG
A
246
55.743
7.114
−1.101
1.00
21.69
A
O


ATOM
3911
N
VAL
A
247
55.579
4.870
−1.000
1.00
20.96
A
N


ATOM
3912
CA
VAL
A
247
54.252
4.871
−0.393
1.00
20.37
A
C


ATOM
3914
CB
VAL
A
247
53.725
3.434
−0.202
1.00
19.99
A
C


ATOM
3916
CG1
VAL
A
247
53.571
2.751
−1.549
1.00
19.77
A
C


ATOM
3920
CG2
VAL
A
247
52.400
3.433
0.549
1.00
19.80
A
C


ATOM
3924
C
VAL
A
247
54.293
5.600
0.955
1.00
20.50
A
C


ATOM
3925
O
VAL
A
247
53.458
6.463
1.227
1.00
19.95
A
O


ATOM
3927
N
GLY
A
248
55.275
5.247
1.783
1.00
20.89
A
N


ATOM
3928
CA
GLY
A
248
55.515
5.921
3.059
1.00
21.19
A
C


ATOM
3931
C
GLY
A
248
54.386
5.801
4.067
1.00
21.62
A
C


ATOM
3932
O
GLY
A
248
54.129
6.736
4.827
1.00
21.37
A
O


ATOM
3934
N
LEU
A
249
53.726
4.645
4.090
1.00
22.43
A
N


ATOM
3935
CA
LEU
A
249
52.558
4.438
4.952
1.00
23.00
A
C


ATOM
3937
CB
LEU
A
249
51.685
3.290
4.421
1.00
22.92
A
C


ATOM
3940
CG
LEU
A
249
50.171
3.488
4.554
1.00
22.33
A
C


ATOM
3942
CD1
LEU
A
249
49.692
4.615
3.649
1.00
21.36
A
C


ATOM
3946
CD2
LEU
A
249
49.430
2.205
4.229
1.00
21.54
A
C


ATOM
3950
C
LEU
A
249
52.978
4.172
6.403
1.00
23.55
A
C


ATOM
3951
O
LEU
A
249
52.390
4.726
7.336
1.00
23.31
A
O


ATOM
3953
N
ALA
A
250
53.996
3.332
6.584
1.00
24.09
A
N


ATOM
3954
CA
ALA
A
250
54.538
3.034
7.913
1.00
24.42
A
C


ATOM
3956
CB
ALA
A
250
55.713
2.072
7.798
1.00
24.82
A
C


ATOM
3960
C
ALA
A
250
54.965
4.302
8.658
1.00
24.51
A
C


ATOM
3961
O
ALA
A
250
54.703
4.439
9.855
1.00
24.78
A
O


ATOM
3963
N
THR
A
251
55.620
5.218
7.944
1.00
24.26
A
N


ATOM
3964
CA
THR
A
251
56.070
6.486
8.520
1.00
23.84
A
C


ATOM
3966
CB
THR
A
251
56.889
7.311
7.504
1.00
23.73
A
C


ATOM
3968
OG1
THR
A
251
57.988
6.530
7.022
1.00
23.21
A
O


ATOM
3970
CG2
THR
A
251
57.413
8.596
8.146
1.00
23.03
A
C


ATOM
3974
C
THR
A
251
54.904
7.354
8.990
1.00
23.80
A
C


ATOM
3975
O
THR
A
251
54.852
7.748
10.154
1.00
24.05
A
O


ATOM
3977
N
LYS
A
252
53.973
7.638
8.082
1.00
23.59
A
N


ATOM
3978
CA
LYS
A
252
52.912
8.617
8.339
1.00
23.66
A
C


ATOM
3980
CB
LYS
A
252
52.238
9.041
7.025
1.00
23.72
A
C


ATOM
3983
CG
LYS
A
252
53.191
9.682
5.999
1.00
24.88
A
C


ATOM
3986
CD
LYS
A
252
53.744
11.038
6.465
1.00
25.58
A
C


ATOM
3989
CE
LYS
A
252
55.000
11.436
5.698
1.00
25.21
A
C


ATOM
3992
NZ
LYS
A
252
55.739
12.535
6.380
1.00
24.66
A
N


ATOM
3996
C
LYS
A
252
51.872
8.114
9.343
1.00
23.54
A
C


ATOM
3997
O
LYS
A
252
51.453
8.856
10.234
1.00
23.17
A
O


ATOM
3999
N
LEU
A
253
51.461
6.858
9.200
1.00
23.95
A
N


ATOM
4000
CA
LEU
A
253
50.579
6.226
10.181
1.00
24.13
A
C


ATOM
4002
CB
LEU
A
253
49.901
4.980
9.596
1.00
23.73
A
C


ATOM
4005
CG
LEU
A
253
48.663
5.213
8.724
1.00
22.61
A
C


ATOM
4007
CD1
LEU
A
253
48.839
6.393
7.784
1.00
22.35
A
C


ATOM
4011
CD2
LEU
A
253
48.328
3.954
7.943
1.00
23.69
A
C


ATOM
4015
C
LEU
A
253
51.404
5.863
11.414
1.00
24.78
A
C


ATOM
4016
O
LEU
A
253
52.176
4.901
11.389
1.00
25.30
A
O


ATOM
4018
N
HIS
A
254
51.238
6.638
12.486
1.00
24.95
A
N


ATOM
4019
CA
HIS
A
254
52.075
6.499
13.685
1.00
25.19
A
C


ATOM
4021
CB
HIS
A
254
51.757
7.594
14.714
1.00
25.53
A
C


ATOM
4024
CG
HIS
A
254
51.801
8.987
14.160
1.00
26.66
A
C


ATOM
4025
ND1
HIS
A
254
52.813
9.434
13.337
1.00
26.59
A
N


ATOM
4027
CE1
HIS
A
254
52.587
10.693
13.008
1.00
27.01
A
C


ATOM
4029
NE2
HIS
A
254
51.468
11.082
13.593
1.00
27.77
A
N


ATOM
4031
CD2
HIS
A
254
50.958
10.036
14.322
1.00
27.37
A
C


ATOM
4033
C
HIS
A
254
51.926
5.125
14.341
1.00
25.07
A
C


ATOM
4034
O
HIS
A
254
52.909
4.535
14.788
1.00
25.17
A
O


ATOM
4036
N
PHE
A
255
50.694
4.627
14.391
1.00
25.01
A
N


ATOM
4037
CA
PHE
A
255
50.392
3.332
15.013
1.00
25.06
A
C


ATOM
4039
CB
PHE
A
255
48.870
3.157
15.153
1.00
24.83
A
C


ATOM
4042
CG
PHE
A
255
48.151
2.999
13.837
1.00
24.67
A
C


ATOM
4043
CD1
PHE
A
255
48.013
1.745
13.248
1.00
25.14
A
C


ATOM
4045
CE1
PHE
A
255
47.361
1.596
12.027
1.00
24.77
A
C


ATOM
4047
CZ
PHE
A
255
46.838
2.708
11.386
1.00
25.06
A
C


ATOM
4049
CE2
PHE
A
255
46.970
3.965
11.963
1.00
25.14
A
C


ATOM
4051
CD2
PHE
A
255
47.624
4.105
13.182
1.00
24.68
A
C


ATOM
4053
C
PHE
A
255
50.962
2.125
14.256
1.00
25.30
A
C


ATOM
4054
O
PHE
A
255
51.288
1.106
14.869
1.00
25.15
A
O


ATOM
4056
N
ALA
A
256
51.078
2.245
12.934
1.00
25.66
A
N


ATOM
4057
CA
ALA
A
256
51.252
1.084
12.055
1.00
25.87
A
C


ATOM
4059
CB
ALA
A
256
50.884
1.454
10.622
1.00
25.83
A
C


ATOM
4063
C
ALA
A
256
52.651
0.468
12.095
1.00
26.20
A
C


ATOM
4064
O
ALA
A
256
53.654
1.177
12.226
1.00
26.11
A
O


ATOM
4066
N
ARG
A
257
52.696
−0.857
11.962
1.00
26.63
A
N


ATOM
4067
CA
ARG
A
257
53.943
−1.621
12.006
1.00
27.23
A
C


ATOM
4069
CB
ARG
A
257
53.705
−2.990
12.643
1.00
27.59
A
C


ATOM
4072
CG
ARG
A
257
53.164
−2.956
14.070
1.00
29.15
A
C


ATOM
4075
CD
ARG
A
257
52.777
−4.360
14.518
1.00
30.54
A
C


ATOM
4078
NE
ARG
A
257
51.707
−4.906
13.678
1.00
31.05
A
N


ATOM
4080
CZ
ARG
A
257
51.478
−6.201
13.463
1.00
31.20
A
C


ATOM
4081
NH1
ARG
A
257
52.242
−7.139
14.018
1.00
31.74
A
N


ATOM
4084
NH2
ARG
A
257
50.471
−6.563
12.674
1.00
31.30
A
N


ATOM
4087
C
ARG
A
257
54.516
−1.828
10.608
1.00
27.05
A
C


ATOM
4088
O
ARG
A
257
53.771
−2.041
9.651
1.00
27.10
A
O


ATOM
4090
N
ASP
A
258
55.844
−1.788
10.508
1.00
26.97
A
N


ATOM
4091
CA
ASP
A
258
56.548
−1.937
9.236
1.00
26.68
A
C


ATOM
4093
CB
ASP
A
258
57.713
−0.945
9.169
1.00
26.49
A
C


ATOM
4096
CG
ASP
A
258
58.241
−0.759
7.764
1.00
26.72
A
C


ATOM
4097
OD1
ASP
A
258
58.470
−1.768
7.065
1.00
26.55
A
O


ATOM
4098
OD2
ASP
A
258
58.428
0.405
7.351
1.00
28.47
A
O


ATOM
4099
C
ASP
A
258
57.049
−3.373
9.073
1.00
26.57
A
C


ATOM
4100
O
ASP
A
258
58.058
−3.759
9.667
1.00
26.72
A
O


ATOM
4102
N
ARG
A
259
56.342
−4.157
8.262
1.00
26.49
A
N


ATOM
4103
CA
ARG
A
259
56.655
−5.575
8.073
1.00
26.58
A
C


ATOM
4105
CB
ARG
A
259
55.578
−6.447
8.738
1.00
27.25
A
C


ATOM
4108
CG
ARG
A
259
55.479
−6.323
10.260
1.00
28.80
A
C


ATOM
4111
CD
ARG
A
259
56.423
−7.277
10.983
1.00
30.14
A
C


ATOM
4114
NE
ARG
A
259
56.188
−7.278
12.428
1.00
32.18
A
N


ATOM
4116
CZ
ARG
A
259
56.604
−6.335
13.275
1.00
32.94
A
C


ATOM
4117
NH1
ARG
A
259
57.290
−5.280
12.842
1.00
34.19
A
N


ATOM
4120
NH2
ARG
A
259
56.329
−6.444
14.572
1.00
32.41
A
N


ATOM
4123
C
ARG
A
259
56.758
−5.934
6.588
1.00
25.53
A
C


ATOM
4124
O
ARG
A
259
55.939
−6.696
6.070
1.00
25.27
A
O


ATOM
4126
N
LEU
A
260
57.759
−5.383
5.905
1.00
24.36
A
N


ATOM
4127
CA
LEU
A
260
57.987
−5.709
4.496
1.00
23.56
A
C


ATOM
4129
CB
LEU
A
260
58.444
−4.482
3.705
1.00
23.49
A
C


ATOM
4132
CG
LEU
A
260
58.738
−4.732
2.220
1.00
22.82
A
C


ATOM
4134
CD1
LEU
A
260
57.541
−5.359
1.522
1.00
22.27
A
C


ATOM
4138
CD2
LEU
A
260
59.145
−3.448
1.530
1.00
23.21
A
C


ATOM
4142
C
LEU
A
260
59.024
−6.812
4.382
1.00
22.93
A
C


ATOM
4143
O
LEU
A
260
58.782
−7.834
3.736
1.00
23.24
A
O


ATOM
4145
N
ILE
A
261
60.175
−6.592
5.013
1.00
22.02
A
N


ATOM
4146
CA
ILE
A
261
61.239
−7.595
5.083
1.00
21.34
A
C


ATOM
4148
CB
ILE
A
261
62.309
−7.215
6.131
1.00
21.16
A
C


ATOM
4150
CG1
ILE
A
261
63.001
−5.893
5.765
1.00
20.68
A
C


ATOM
4153
CD1
ILE
A
261
63.318
−5.016
6.972
1.00
19.12
A
C


ATOM
4157
CG2
ILE
A
261
63.336
−8.335
6.266
1.00
20.90
A
C


ATOM
4161
C
ILE
A
261
60.644
−8.943
5.477
1.00
21.18
A
C


ATOM
4162
O
ILE
A
261
60.982
−9.973
4.900
1.00
20.99
A
O


ATOM
4164
N
GLU
A
262
59.747
−8.915
6.459
1.00
21.36
A
N


ATOM
4165
CA
GLU
A
262
59.060
−10.112
6.927
1.00
21.68
A
C


ATOM
4167
CB
GLU
A
262
58.375
−9.849
8.276
1.00
21.72
A
C


ATOM
4170
CG
GLU
A
262
59.332
−9.744
9.477
1.00
21.84
A
C


ATOM
4173
CD
GLU
A
262
59.863
−8.335
9.740
1.00
21.66
A
C


ATOM
4174
OE1
GLU
A
262
59.610
−7.413
8.933
1.00
21.94
A
O


ATOM
4175
OE2
GLU
A
262
60.540
−8.150
10.772
1.00
21.41
A
O


ATOM
4176
C
GLU
A
262
58.036
−10.625
5.911
1.00
22.32
A
C


ATOM
4177
O
GLU
A
262
57.901
−11.837
5.728
1.00
23.24
A
O


ATOM
4179
N
SER
A
263
57.313
−9.712
5.262
1.00
22.49
A
N


ATOM
4180
CA
SER
A
263
56.288
−10.094
4.277
1.00
22.31
A
C


ATOM
4182
CB
SER
A
263
55.386
−8.909
3.919
1.00
22.29
A
C


ATOM
4185
OG
SER
A
263
54.431
−8.678
4.939
1.00
22.39
A
O


ATOM
4187
C
SER
A
263
56.883
−10.687
3.004
1.00
22.14
A
C


ATOM
4188
O
SER
A
263
56.274
−11.555
2.382
1.00
22.58
A
O


ATOM
4190
N
PHE
A
264
58.059
−10.214
2.606
1.00
22.01
A
N


ATOM
4191
CA
PHE
A
264
58.750
−10.795
1.460
1.00
22.14
A
C


ATOM
4193
CB
PHE
A
264
59.942
−9.933
1.038
1.00
22.16
A
C


ATOM
4196
CG
PHE
A
264
60.511
−10.311
−0.297
1.00
21.05
A
C


ATOM
4197
CD1
PHE
A
264
59.905
−9.880
−1.467
1.00
20.84
A
C


ATOM
4199
CE1
PHE
A
264
60.418
−10.230
−2.703
1.00
21.07
A
C


ATOM
4201
CZ
PHE
A
264
61.552
−11.021
−2.778
1.00
22.11
A
C


ATOM
4203
CE2
PHE
A
264
62.164
−11.460
−1.615
1.00
21.87
A
C


ATOM
4205
CD2
PHE
A
264
61.641
−11.108
−0.384
1.00
20.79
A
C


ATOM
4207
C
PHE
A
264
59.212
−12.211
1.800
1.00
22.40
A
C


ATOM
4208
O
PHE
A
264
58.950
−13.149
1.042
1.00
22.39
A
O


ATOM
4210
N
TYR
A
265
59.885
−12.349
2.946
1.00
22.32
A
N


ATOM
4211
CA
TYR
A
265
60.319
−13.651
3.472
1.00
22.09
A
C


ATOM
4213
CB
TYR
A
265
60.930
−13.489
4.872
1.00
22.28
A
C


ATOM
4216
CG
TYR
A
265
61.069
−14.783
5.649
1.00
25.25
A
C


ATOM
4217
CD1
TYR
A
265
62.150
−15.636
5.438
1.00
27.20
A
C


ATOM
4219
CE1
TYR
A
265
62.281
−16.826
6.149
1.00
27.66
A
C


ATOM
4221
CZ
TYR
A
265
61.322
−17.173
7.084
1.00
29.34
A
C


ATOM
4222
OH
TYR
A
265
61.447
−18.349
7.791
1.00
32.52
A
O


ATOM
4224
CE2
TYR
A
265
60.238
−16.344
7.314
1.00
29.12
A
C


ATOM
4226
CD2
TYR
A
265
60.117
−15.156
6.598
1.00
28.54
A
C


ATOM
4228
C
TYR
A
265
59.163
−14.649
3.513
1.00
21.42
A
C


ATOM
4229
O
TYR
A
265
59.334
−15.821
3.175
1.00
21.62
A
O


ATOM
4231
N
TRP
A
266
57.992
−14.180
3.935
1.00
20.65
A
N


ATOM
4232
CA
TRP
A
266
56.774
−14.980
3.860
1.00
20.27
A
C


ATOM
4234
CB
TRP
A
266
55.576
−14.189
4.407
1.00
20.42
A
C


ATOM
4237
CG
TRP
A
266
54.261
−14.891
4.247
1.00
19.95
A
C


ATOM
4238
CD1
TRP
A
266
53.460
−14.889
3.143
1.00
19.27
A
C


ATOM
4240
NE1
TRP
A
266
52.339
−15.648
3.368
1.00
19.44
A
N


ATOM
4242
CE2
TRP
A
266
52.394
−16.154
4.639
1.00
19.32
A
C


ATOM
4243
CD2
TRP
A
266
53.595
−15.697
5.223
1.00
19.63
A
C


ATOM
4244
CE3
TRP
A
266
53.895
−16.075
6.537
1.00
20.02
A
C


ATOM
4246
CZ3
TRP
A
266
53.000
−16.890
7.215
1.00
20.91
A
C


ATOM
4248
CH2
TRP
A
266
51.812
−17.331
6.604
1.00
19.64
A
C


ATOM
4250
CZ2
TRP
A
266
51.493
−16.975
5.321
1.00
18.62
A
C


ATOM
4252
C
TRP
A
266
56.509
−15.411
2.416
1.00
19.60
A
C


ATOM
4253
O
TRP
A
266
56.278
−16.590
2.146
1.00
19.63
A
O


ATOM
4255
N
ALA
A
267
56.556
−14.446
1.498
1.00
18.71
A
N


ATOM
4256
CA
ALA
A
267
56.272
−14.687
0.081
1.00
18.06
A
C


ATOM
4258
CB
ALA
A
267
56.264
−13.372
−0.682
1.00
18.02
A
C


ATOM
4262
C
ALA
A
267
57.241
−15.669
−0.581
1.00
17.64
A
C


ATOM
4263
O
ALA
A
267
56.872
−16.341
−1.542
1.00
17.61
A
O


ATOM
4265
N
VAL
A
268
58.470
−15.748
−0.069
1.00
17.18
A
N


ATOM
4266
CA
VAL
A
268
59.479
−16.690
−0.579
1.00
16.54
A
C


ATOM
4268
CB
VAL
A
268
60.872
−16.405
0.039
1.00
16.49
A
C


ATOM
4270
CG1
VAL
A
268
61.390
−15.062
−0.451
1.00
16.73
A
C


ATOM
4274
CG2
VAL
A
268
61.866
−17.511
−0.297
1.00
16.29
A
C


ATOM
4278
C
VAL
A
268
59.080
−18.154
−0.340
1.00
15.77
A
C


ATOM
4279
O
VAL
A
268
59.385
−19.028
−1.150
1.00
15.33
A
O


ATOM
4281
N
GLY
A
269
58.395
−18.415
0.766
1.00
15.52
A
N


ATOM
4282
CA
GLY
A
269
57.832
−19.737
1.016
1.00
15.52
A
C


ATOM
4285
C
GLY
A
269
56.673
−20.066
0.090
1.00
15.20
A
C


ATOM
4286
O
GLY
A
269
56.391
−21.237
−0.160
1.00
14.64
A
O


ATOM
4288
N
VAL
A
270
56.007
−19.032
−0.419
1.00
14.97
A
N


ATOM
4289
CA
VAL
A
270
54.835
−19.200
−1.280
1.00
14.94
A
C


ATOM
4291
CB
VAL
A
270
53.887
−17.979
−1.178
1.00
14.38
A
C


ATOM
4293
CG1
VAL
A
270
52.554
−18.286
−1.826
1.00
13.66
A
C


ATOM
4297
CG2
VAL
A
270
53.677
−17.584
0.272
1.00
12.55
A
C


ATOM
4301
C
VAL
A
270
55.230
−19.429
−2.747
1.00
15.75
A
C


ATOM
4302
O
VAL
A
270
54.475
−20.036
−3.508
1.00
16.17
A
O


ATOM
4304
N
ALA
A
271
56.410
−18.948
−3.140
1.00
16.28
A
N


ATOM
4305
CA
ALA
A
271
56.906
−19.120
−4.510
1.00
16.56
A
C


ATOM
4307
CB
ALA
A
271
56.190
−18.161
−5.450
1.00
16.49
A
C


ATOM
4311
C
ALA
A
271
58.429
−18.926
−4.586
1.00
16.90
A
C


ATOM
4312
O
ALA
A
271
58.925
−17.849
−4.925
1.00
16.39
A
O


ATOM
4314
N
PHE
A
272
59.155
−19.993
−4.273
1.00
17.53
A
N


ATOM
4315
CA
PHE
A
272
60.616
−19.960
−4.183
1.00
18.21
A
C


ATOM
4317
CB
PHE
A
272
61.119
−21.181
−3.416
1.00
18.52
A
C


ATOM
4320
CG
PHE
A
272
61.061
−22.460
−4.207
1.00
19.27
A
C


ATOM
4321
CD1
PHE
A
272
62.180
−22.915
−4.894
1.00
19.23
A
C


ATOM
4323
CE1
PHE
A
272
62.132
−24.095
−5.624
1.00
21.26
A
C


ATOM
4325
CZ
PHE
A
272
60.951
−24.832
−5.677
1.00
22.55
A
C


ATOM
4327
CE2
PHE
A
272
59.825
−24.383
−4.999
1.00
21.20
A
C


ATOM
4329
CD2
PHE
A
272
59.885
−23.204
−4.271
1.00
20.42
A
C


ATOM
4331
C
PHE
A
272
61.325
−19.925
−5.533
1.00
18.82
A
C


ATOM
4332
O
PHE
A
272
62.415
−19.362
−5.642
1.00
19.34
A
O


ATOM
4334
N
GLU
A
273
60.728
−20.554
−6.545
1.00
19.20
A
N


ATOM
4335
CA
GLU
A
273
61.364
−20.679
−7.859
1.00
19.20
A
C


ATOM
4337
CB
GLU
A
273
60.476
−21.457
−8.842
1.00
19.46
A
C


ATOM
4340
CG
GLU
A
273
60.093
−22.880
−8.399
1.00
20.71
A
C


ATOM
4343
CD
GLU
A
273
58.655
−23.005
−7.879
1.00
22.87
A
C


ATOM
4344
OE1
GLU
A
273
58.171
−22.086
−7.178
1.00
22.37
A
O


ATOM
4345
OE2
GLU
A
273
58.008
−24.035
−8.173
1.00
22.23
A
O


ATOM
4346
C
GLU
A
273
61.680
−19.288
−8.416
1.00
18.84
A
C


ATOM
4347
O
GLU
A
273
60.846
−18.388
−8.333
1.00
19.02
A
O


ATOM
4349
N
PRO
A
274
62.887
−19.108
−8.984
1.00
18.67
A
N


ATOM
4350
CA
PRO
A
274
63.353
−17.773
−9.375
1.00
18.87
A
C


ATOM
4352
CB
PRO
A
274
64.762
−18.034
−9.924
1.00
18.89
A
C


ATOM
4355
CG
PRO
A
274
64.786
−19.471
−10.280
1.00
18.67
A
C


ATOM
4358
CD
PRO
A
274
63.861
−20.157
−9.335
1.00
18.65
A
C


ATOM
4361
C
PRO
A
274
62.487
−17.066
−10.422
1.00
19.21
A
C


ATOM
4362
O
PRO
A
274
62.470
−15.837
−10.467
1.00
19.76
A
O


ATOM
4363
N
GLN
A
275
61.771
−17.829
−11.243
1.00
19.37
A
N


ATOM
4364
CA
GLN
A
275
60.924
−17.247
−12.286
1.00
19.69
A
C


ATOM
4366
CB
GLN
A
275
60.631
−18.272
−13.395
1.00
19.95
A
C


ATOM
4369
CG
GLN
A
275
59.739
−19.459
−12.995
1.00
20.88
A
C


ATOM
4372
CD
GLN
A
275
60.526
−20.705
−12.614
1.00
21.94
A
C


ATOM
4373
OE1
GLN
A
275
61.655
−20.620
−12.130
1.00
24.29
A
O


ATOM
4374
NE2
GLN
A
275
59.924
−21.870
−12.826
1.00
22.72
A
N


ATOM
4377
C
GLN
A
275
59.607
−16.633
−11.782
1.00
19.72
A
C


ATOM
4378
O
GLN
A
275
58.905
−15.991
−12.562
1.00
20.27
A
O


ATOM
4380
N
TYR
A
276
59.270
−16.819
−10.504
1.00
19.68
A
N


ATOM
4381
CA
TYR
A
276
58.020
−16.279
−9.942
1.00
19.96
A
C


ATOM
4383
CB
TYR
A
276
57.339
−17.321
−9.044
1.00
20.06
A
C


ATOM
4386
CG
TYR
A
276
56.799
−18.541
−9.762
1.00
21.44
A
C


ATOM
4387
CD1
TYR
A
276
55.960
−18.417
−10.867
1.00
21.90
A
C


ATOM
4389
CE1
TYR
A
276
55.455
−19.537
−11.516
1.00
22.01
A
C


ATOM
4391
CZ
TYR
A
276
55.773
−20.800
−11.051
1.00
23.26
A
C


ATOM
4392
OH
TYR
A
276
55.276
−21.917
−11.683
1.00
24.08
A
O


ATOM
4394
CE2
TYR
A
276
56.592
−20.949
−9.946
1.00
23.34
A
C


ATOM
4396
CD2
TYR
A
276
57.095
−19.824
−9.306
1.00
22.64
A
C


ATOM
4398
C
TYR
A
276
58.219
−14.977
−9.147
1.00
19.98
A
C


ATOM
4399
O
TYR
A
276
57.639
−14.802
−8.072
1.00
19.72
A
O


ATOM
4401
N
SER
A
277
59.021
−14.059
−9.682
1.00
20.07
A
N


ATOM
4402
CA
SER
A
277
59.270
−12.770
−9.027
1.00
19.67
A
C


ATOM
4404
CB
SER
A
277
60.267
−11.938
−9.838
1.00
19.60
A
C


ATOM
4407
OG
SER
A
277
61.513
−12.603
−9.956
1.00
20.14
A
O


ATOM
4409
C
SER
A
277
57.984
−11.973
−8.822
1.00
19.33
A
C


ATOM
4410
O
SER
A
277
57.776
−11.385
−7.761
1.00
19.21
A
O


ATOM
4412
N
ASP
A
278
57.123
−11.959
−9.835
1.00
19.20
A
N


ATOM
4413
CA
ASP
A
278
55.859
−11.226
−9.754
1.00
19.25
A
C


ATOM
4415
CB
ASP
A
278
55.085
−11.316
−11.077
1.00
19.35
A
C


ATOM
4418
CG
ASP
A
278
55.629
−10.380
−12.143
1.00
18.93
A
C


ATOM
4419
OD1
ASP
A
278
56.348
−9.419
−11.796
1.00
18.90
A
O


ATOM
4420
OD2
ASP
A
278
55.327
−10.600
−13.333
1.00
18.56
A
O


ATOM
4421
C
ASP
A
278
54.979
−11.716
−8.606
1.00
19.13
A
C


ATOM
4422
O
ASP
A
278
54.356
−10.908
−7.916
1.00
19.10
A
O


ATOM
4424
N
CYS
A
279
54.930
−13.031
−8.403
1.00
18.93
A
N


ATOM
4425
CA
CYS
A
279
54.146
−13.601
−7.307
1.00
18.82
A
C


ATOM
4427
CB
CYS
A
279
54.090
−15.129
−7.401
1.00
18.89
A
C


ATOM
4430
SG
CYS
A
279
52.896
−15.884
−6.264
1.00
18.55
A
S


ATOM
4432
C
CYS
A
279
54.716
−13.185
−5.956
1.00
18.54
A
C


ATOM
4433
O
CYS
A
279
53.965
−12.865
−5.033
1.00
18.37
A
O


ATOM
4435
N
ARG
A
280
56.044
−13.189
−5.853
1.00
18.40
A
N


ATOM
4436
CA
ARG
A
280
56.730
−12.759
−4.635
1.00
18.00
A
C


ATOM
4438
CB
ARG
A
280
58.239
−13.013
−4.735
1.00
18.28
A
C


ATOM
4441
CG
ARG
A
280
58.634
−14.477
−4.592
1.00
18.99
A
C


ATOM
4444
CD
ARG
A
280
60.137
−14.630
−4.420
1.00
19.95
A
C


ATOM
4447
NE
ARG
A
280
60.867
−14.212
−5.615
1.00
21.16
A
N


ATOM
4449
CZ
ARG
A
280
61.053
−14.964
−6.700
1.00
23.15
A
C


ATOM
4450
NH1
ARG
A
280
60.562
−16.198
−6.772
1.00
24.11
A
N


ATOM
4453
NH2
ARG
A
280
61.736
−14.475
−7.728
1.00
24.44
A
N


ATOM
4456
C
ARG
A
280
56.464
−11.285
−4.344
1.00
17.11
A
C


ATOM
4457
O
ARG
A
280
56.147
−10.923
−3.210
1.00
16.85
A
O


ATOM
4459
N
ASN
A
281
56.586
−10.443
−5.369
1.00
16.30
A
N


ATOM
4460
CA
ASN
A
281
56.313
−9.014
−5.220
1.00
15.91
A
C


ATOM
4462
CB
ASN
A
281
56.684
−8.244
−6.493
1.00
16.20
A
C


ATOM
4465
CG
ASN
A
281
58.192
−8.136
−6.703
1.00
17.16
A
C


ATOM
4466
OD1
ASN
A
281
58.988
−8.551
−5.858
1.00
17.08
A
O


ATOM
4467
ND2
ASN
A
281
58.588
−7.568
−7.839
1.00
18.22
A
N


ATOM
4470
C
ASN
A
281
54.857
−8.741
−4.841
1.00
15.14
A
C


ATOM
4471
O
ASN
A
281
54.595
−7.924
−3.964
1.00
15.32
A
O


ATOM
4473
N
SER
A
282
53.920
−9.432
−5.491
1.00
14.30
A
N


ATOM
4474
CA
SER
A
282
52.494
−9.294
−5.173
1.00
13.39
A
C


ATOM
4476
CB
SER
A
282
51.631
−10.127
−6.124
1.00
13.27
A
C


ATOM
4479
OG
SER
A
282
51.539
−9.524
−7.400
1.00
13.30
A
O


ATOM
4481
C
SER
A
282
52.202
−9.701
−3.731
1.00
12.98
A
C


ATOM
4482
O
SER
A
282
51.743
−8.880
−2.933
1.00
12.94
A
O


ATOM
4484
N
VAL
A
283
52.471
−10.963
−3.402
1.00
12.45
A
N


ATOM
4485
CA
VAL
A
283
52.241
−11.475
−2.050
1.00
12.34
A
C


ATOM
4487
CB
VAL
A
283
52.831
−12.895
−1.858
1.00
12.07
A
C


ATOM
4489
CG1
VAL
A
283
52.867
−13.272
−0.387
1.00
11.16
A
C


ATOM
4493
CG2
VAL
A
283
52.029
−13.918
−2.639
1.00
10.41
A
C


ATOM
4497
C
VAL
A
283
52.837
−10.520
−1.015
1.00
12.92
A
C


ATOM
4498
O
VAL
A
283
52.173
−10.150
−0.048
1.00
12.86
A
O


ATOM
4500
N
ALA
A
284
54.082
−10.111
−1.243
1.00
13.80
A
N


ATOM
4501
CA
ALA
A
284
54.772
−9.179
−0.351
1.00
14.74
A
C


ATOM
4503
CB
ALA
A
284
56.179
−8.900
−0.871
1.00
14.73
A
C


ATOM
4507
C
ALA
A
284
54.006
−7.864
−0.172
1.00
15.30
A
C


ATOM
4508
O
ALA
A
284
53.811
−7.400
0.952
1.00
14.93
A
O


ATOM
4510
N
LYS
A
285
53.578
−7.272
−1.283
1.00
16.13
A
N


ATOM
4511
CA
LYS
A
285
52.841
−6.012
−1.248
1.00
17.03
A
C


ATOM
4513
CB
LYS
A
285
52.562
−5.503
−2.668
1.00
17.14
A
C


ATOM
4516
CG
LYS
A
285
53.756
−4.834
−3.335
1.00
18.60
A
C


ATOM
4519
CD
LYS
A
285
53.407
−4.320
−4.722
1.00
21.08
A
C


ATOM
4522
CE
LYS
A
285
54.618
−3.718
−5.417
1.00
22.65
A
C


ATOM
4525
NZ
LYS
A
285
54.341
−3.399
−6.848
1.00
24.04
A
N


ATOM
4529
C
LYS
A
285
51.529
−6.160
−0.481
1.00
17.73
A
C


ATOM
4530
O
LYS
A
285
51.239
−5.379
0.431
1.00
17.94
A
O


ATOM
4532
N
MET
A
286
50.747
−7.171
−0.846
1.00
18.03
A
N


ATOM
4533
CA
MET
A
286
49.426
−7.367
−0.253
1.00
18.01
A
C


ATOM
4535
CB
MET
A
286
48.670
−8.498
−0.966
1.00
18.01
A
C


ATOM
4538
CG
MET
A
286
48.323
−8.209
−2.429
1.00
17.41
A
C


ATOM
4541
SD
MET
A
286
47.631
−6.560
−2.713
1.00
16.92
A
S


ATOM
4542
CE
MET
A
286
49.115
−5.597
−2.995
1.00
16.98
A
C


ATOM
4546
C
MET
A
286
49.524
−7.651
1.240
1.00
17.81
A
C


ATOM
4547
O
MET
A
286
48.835
−7.017
2.042
1.00
17.92
A
O


ATOM
4549
N
PHE
A
287
50.394
−8.587
1.606
1.00
17.47
A
N


ATOM
4550
CA
PHE
A
287
50.575
−8.976
3.007
1.00
17.44
A
C


ATOM
4552
CB
PHE
A
287
51.516
−10.186
3.094
1.00
17.98
A
C


ATOM
4555
CG
PHE
A
287
51.463
−10.925
4.409
1.00
20.17
A
C


ATOM
4556
CD1
PHE
A
287
50.248
−11.252
5.004
1.00
22.99
A
C


ATOM
4558
CE1
PHE
A
287
50.204
−11.947
6.205
1.00
23.48
A
C


ATOM
4560
CZ
PHE
A
287
51.380
−12.337
6.820
1.00
25.00
A
C


ATOM
4562
CE2
PHE
A
287
52.598
−12.029
6.233
1.00
25.35
A
C


ATOM
4564
CD2
PHE
A
287
52.634
−11.332
5.032
1.00
23.16
A
C


ATOM
4566
C
PHE
A
287
51.096
−7.818
3.871
1.00
16.40
A
C


ATOM
4567
O
PHE
A
287
50.848
−7.781
5.076
1.00
15.60
A
O


ATOM
4569
N
SER
A
288
51.809
−6.879
3.250
1.00
15.81
A
N


ATOM
4570
CA
SER
A
288
52.251
−5.667
3.934
1.00
15.38
A
C


ATOM
4572
CB
SER
A
288
53.333
−4.945
3.131
1.00
15.38
A
C


ATOM
4575
OG
SER
A
288
54.539
−5.688
3.137
1.00
15.78
A
O


ATOM
4577
C
SER
A
288
51.081
−4.728
4.202
1.00
15.29
A
C


ATOM
4578
O
SER
A
288
51.029
−4.099
5.256
1.00
15.32
A
O


ATOM
4580
N
PHE
A
289
50.149
−4.631
3.253
1.00
15.52
A
N


ATOM
4581
CA
PHE
A
289
48.899
−3.885
3.480
1.00
15.49
A
C


ATOM
4583
CB
PHE
A
289
48.121
−3.650
2.176
1.00
15.43
A
C


ATOM
4586
CG
PHE
A
289
48.484
−2.367
1.479
1.00
15.12
A
C


ATOM
4587
CD1
PHE
A
289
48.164
−1.144
2.049
1.00
14.80
A
C


ATOM
4589
CE1
PHE
A
289
48.499
0.040
1.420
1.00
16.15
A
C


ATOM
4591
CZ
PHE
A
289
49.159
0.011
0.206
1.00
17.05
A
C


ATOM
4593
CE2
PHE
A
289
49.479
−1.204
−0.376
1.00
17.05
A
C


ATOM
4595
CD2
PHE
A
289
49.144
−2.383
0.261
1.00
16.16
A
C


ATOM
4597
C
PHE
A
289
48.002
−4.582
4.503
1.00
15.27
A
C


ATOM
4598
O
PHE
A
289
47.393
−3.923
5.345
1.00
15.17
A
O


ATOM
4600
N
VAL
A
290
47.935
−5.910
4.431
1.00
15.14
A
N


ATOM
4601
CA
VAL
A
290
47.139
−6.696
5.373
1.00
15.03
A
C


ATOM
4603
CB
VAL
A
290
47.224
−8.201
5.068
1.00
14.64
A
C


ATOM
4605
CG1
VAL
A
290
46.571
−9.010
6.175
1.00
14.66
A
C


ATOM
4609
CG2
VAL
A
290
46.562
−8.497
3.739
1.00
14.94
A
C


ATOM
4613
C
VAL
A
290
47.551
−6.445
6.827
1.00
15.27
A
C


ATOM
4614
O
VAL
A
290
46.698
−6.185
7.673
1.00
15.36
A
O


ATOM
4616
N
THR
A
291
48.851
−6.503
7.110
1.00
15.61
A
N


ATOM
4617
CA
THR
A
291
49.340
−6.286
8.477
1.00
15.61
A
C


ATOM
4619
CB
THR
A
291
50.886
−6.410
8.595
1.00
15.42
A
C


ATOM
4621
OG1
THR
A
291
51.520
−5.386
7.819
1.00
14.83
A
O


ATOM
4623
CG2
THR
A
291
51.369
−7.784
8.132
1.00
14.64
A
C


ATOM
4627
C
THR
A
291
48.911
−4.916
9.001
1.00
15.68
A
C


ATOM
4628
O
THR
A
291
48.504
−4.791
10.157
1.00
16.01
A
O


ATOM
4630
N
ILE
A
292
48.991
−3.903
8.141
1.00
15.70
A
N


ATOM
4631
CA
ILE
A
292
48.639
−2.533
8.516
1.00
15.64
A
C


ATOM
4633
CB
ILE
A
292
49.192
−1.505
7.500
1.00
15.68
A
C


ATOM
4635
CG1
ILE
A
292
50.722
−1.490
7.557
1.00
15.54
A
C


ATOM
4638
CD1
ILE
A
292
51.357
−0.392
6.739
1.00
16.00
A
C


ATOM
4642
CG2
ILE
A
292
48.639
−0.108
7.780
1.00
15.12
A
C


ATOM
4646
C
ILE
A
292
47.131
−2.359
8.661
1.00
15.48
A
C


ATOM
4647
O
ILE
A
292
46.669
−1.760
9.631
1.00
15.61
A
O


ATOM
4649
N
ILE
A
293
46.367
−2.885
7.708
1.00
15.26
A
N


ATOM
4650
CA
ILE
A
293
44.909
−2.805
7.779
1.00
15.32
A
C


ATOM
4652
CB
ILE
A
293
44.231
−3.333
6.495
1.00
15.16
A
C


ATOM
4654
CG1
ILE
A
293
44.602
−2.472
5.282
1.00
15.39
A
C


ATOM
4657
CD1
ILE
A
293
43.968
−1.107
5.275
1.00
15.43
A
C


ATOM
4661
CG2
ILE
A
293
42.719
−3.348
6.658
1.00
15.54
A
C


ATOM
4665
C
ILE
A
293
44.394
−3.586
8.991
1.00
15.79
A
C


ATOM
4666
O
ILE
A
293
43.465
−3.144
9.664
1.00
15.61
A
O


ATOM
4668
N
ASP
A
294
45.012
−4.733
9.273
1.00
16.58
A
N


ATOM
4669
CA
ASP
A
294
44.653
−5.541
10.445
1.00
17.14
A
C


ATOM
4671
CB
ASP
A
294
45.511
−6.814
10.521
1.00
17.55
A
C


ATOM
4674
CG
ASP
A
294
45.018
−7.803
11.576
1.00
18.98
A
C


ATOM
4675
OD1
ASP
A
294
43.790
−7.884
11.806
1.00
20.79
A
O


ATOM
4676
OD2
ASP
A
294
45.861
−8.513
12.169
1.00
18.90
A
O


ATOM
4677
C
ASP
A
294
44.788
−4.741
11.743
1.00
16.97
A
C


ATOM
4678
O
ASP
A
294
43.999
−4.924
12.667
1.00
17.05
A
O


ATOM
4680
N
ASP
A
295
45.781
−3.857
11.808
1.00
16.76
A
N


ATOM
4681
CA
ASP
A
295
45.937
−2.965
12.958
1.00
16.73
A
C


ATOM
4683
CB
ASP
A
295
47.305
−2.268
12.940
1.00
16.88
A
C


ATOM
4686
CG
ASP
A
295
48.461
−3.220
13.210
1.00
17.30
A
C


ATOM
4687
OD1
ASP
A
295
48.224
−4.372
13.634
1.00
17.28
A
O


ATOM
4688
OD2
ASP
A
295
49.620
−2.806
12.998
1.00
18.54
A
O


ATOM
4689
C
ASP
A
295
44.825
−1.915
13.018
1.00
16.43
A
C


ATOM
4690
O
ASP
A
295
44.347
−1.589
14.105
1.00
16.59
A
O


ATOM
4692
N
ILE
A
296
44.420
−1.390
11.859
1.00
15.90
A
N


ATOM
4693
CA
ILE
A
296
43.353
−0.378
11.791
1.00
15.30
A
C


ATOM
4695
CB
ILE
A
296
43.100
0.114
10.346
1.00
14.79
A
C


ATOM
4697
CG1
ILE
A
296
44.304
0.885
9.813
1.00
14.50
A
C


ATOM
4700
CD1
ILE
A
296
44.210
1.200
8.336
1.00
13.16
A
C


ATOM
4704
CG2
ILE
A
296
41.886
1.022
10.295
1.00
13.81
A
C


ATOM
4708
C
ILE
A
296
42.034
−0.917
12.345
1.00
15.43
A
C


ATOM
4709
O
ILE
A
296
41.305
−0.200
13.033
1.00
15.53
A
O


ATOM
4711
N
TYR
A
297
41.736
−2.178
12.040
1.00
15.29
A
N


ATOM
4712
CA
TYR
A
297
40.501
−2.820
12.495
1.00
15.11
A
C


ATOM
4714
CB
TYR
A
297
40.111
−3.966
11.553
1.00
15.56
A
C


ATOM
4717
CG
TYR
A
297
39.399
−3.528
10.288
1.00
16.05
A
C


ATOM
4718
CD1
TYR
A
297
38.010
−3.476
10.235
1.00
15.95
A
C


ATOM
4720
CE1
TYR
A
297
37.348
−3.086
9.081
1.00
15.39
A
C


ATOM
4722
CZ
TYR
A
297
38.074
−2.746
7.959
1.00
16.60
A
C


ATOM
4723
OH
TYR
A
297
37.414
−2.357
6.817
1.00
18.35
A
O


ATOM
4725
CE2
TYR
A
297
39.456
−2.794
7.982
1.00
16.80
A
C


ATOM
4727
CD2
TYR
A
297
40.110
−3.187
9.142
1.00
16.66
A
C


ATOM
4729
C
TYR
A
297
40.601
−3.343
13.928
1.00
14.50
A
C


ATOM
4730
O
TYR
A
297
39.645
−3.239
14.695
1.00
14.52
A
O


ATOM
4732
N
ASP
A
298
41.757
−3.901
14.280
1.00
14.10
A
N


ATOM
4733
CA
ASP
A
298
41.949
−4.561
15.575
1.00
13.63
A
C


ATOM
4735
CB
ASP
A
298
43.212
−5.434
15.531
1.00
13.70
A
C


ATOM
4738
CG
ASP
A
298
43.478
−6.162
16.835
1.00
13.63
A
C


ATOM
4739
OD1
ASP
A
298
42.511
−6.539
17.530
1.00
14.13
A
O


ATOM
4740
OD2
ASP
A
298
44.666
−6.368
17.156
1.00
13.89
A
O


ATOM
4741
C
ASP
A
298
42.044
−3.573
16.741
1.00
13.00
A
C


ATOM
4742
O
ASP
A
298
41.295
−3.681
17.710
1.00
12.88
A
O


ATOM
4744
N
VAL
A
299
42.959
−2.614
16.637
1.00
12.31
A
N


ATOM
4745
CA
VAL
A
299
43.312
−1.760
17.774
1.00
11.67
A
C


ATOM
4747
CB
VAL
A
299
44.805
−1.930
18.142
1.00
11.42
A
C


ATOM
4749
CG1
VAL
A
299
45.071
−3.349
18.602
1.00
11.41
A
C


ATOM
4753
CG2
VAL
A
299
45.703
−1.574
16.965
1.00
10.40
A
C


ATOM
4757
C
VAL
A
299
43.020
−0.267
17.587
1.00
11.59
A
C


ATOM
4758
O
VAL
A
299
42.551
0.385
18.524
1.00
11.49
A
O


ATOM
4760
N
TYR
A
300
43.289
0.268
16.394
1.00
11.13
A
N


ATOM
4761
CA
TYR
A
300
43.330
1.722
16.189
1.00
10.45
A
C


ATOM
4763
CB
TYR
A
300
44.389
2.094
15.139
1.00
9.99
A
C


ATOM
4766
CG
TYR
A
300
44.603
3.590
15.022
1.00
9.37
A
C


ATOM
4767
CD1
TYR
A
300
45.202
4.309
16.055
1.00
9.54
A
C


ATOM
4769
CE1
TYR
A
300
45.389
5.686
15.966
1.00
6.83
A
C


ATOM
4771
CZ
TYR
A
300
44.970
6.358
14.840
1.00
5.23
A
C


ATOM
4772
OH
TYR
A
300
45.155
7.715
14.752
1.00
3.12
A
O


ATOM
4774
CE2
TYR
A
300
44.373
5.672
13.800
1.00
6.82
A
C


ATOM
4776
CD2
TYR
A
300
44.188
4.292
13.896
1.00
8.25
A
C


ATOM
4778
C
TYR
A
300
41.989
2.370
15.821
1.00
10.48
A
C


ATOM
4779
O
TYR
A
300
41.675
3.448
16.317
1.00
10.25
A
O


ATOM
4781
N
GLY
A
301
41.209
1.729
14.956
1.00
11.04
A
N


ATOM
4782
CA
GLY
A
301
39.992
2.347
14.415
1.00
11.50
A
C


ATOM
4785
C
GLY
A
301
38.727
2.030
15.193
1.00
11.87
A
C


ATOM
4786
O
GLY
A
301
38.509
0.882
15.585
1.00
11.70
A
O


ATOM
4788
N
THR
A
302
37.887
3.045
15.411
1.00
12.42
A
N


ATOM
4789
CA
THR
A
302
36.572
2.829
16.024
1.00
13.04
A
C


ATOM
4791
CB
THR
A
302
35.913
4.137
16.546
1.00
13.14
A
C


ATOM
4793
OG1
THR
A
302
35.606
5.009
15.452
1.00
14.40
A
O


ATOM
4795
CG2
THR
A
302
36.826
4.852
17.535
1.00
12.53
A
C


ATOM
4799
C
THR
A
302
35.663
2.174
14.995
1.00
13.17
A
C


ATOM
4800
O
THR
A
302
35.965
2.180
13.803
1.00
12.57
A
O


ATOM
4802
N
LEU
A
303
34.551
1.613
15.456
1.00
13.95
A
N


ATOM
4803
CA
LEU
A
303
33.688
0.826
14.580
1.00
14.80
A
C


ATOM
4805
CB
LEU
A
303
32.567
0.138
15.375
1.00
14.99
A
C


ATOM
4808
CG
LEU
A
303
32.178
−1.259
14.876
1.00
15.81
A
C


ATOM
4810
CD1
LEU
A
303
33.326
−2.239
15.080
1.00
16.28
A
C


ATOM
4814
CD2
LEU
A
303
30.927
−1.768
15.578
1.00
17.42
A
C


ATOM
4818
C
LEU
A
303
33.114
1.690
13.456
1.00
15.44
A
C


ATOM
4819
O
LEU
A
303
33.109
1.275
12.295
1.00
15.80
A
O


ATOM
4821
N
ASP
A
304
32.659
2.896
13.803
1.00
15.85
A
N


ATOM
4822
CA
ASP
A
304
32.105
3.840
12.823
1.00
15.89
A
C


ATOM
4824
CB
ASP
A
304
31.645
5.137
13.509
1.00
16.11
A
C


ATOM
4827
CG
ASP
A
304
30.370
4.957
14.326
1.00
15.63
A
C


ATOM
4828
OD1
ASP
A
304
29.443
4.266
13.852
1.00
13.49
A
O


ATOM
4829
OD2
ASP
A
304
30.291
5.522
15.439
1.00
14.30
A
O


ATOM
4830
C
ASP
A
304
33.105
4.167
11.713
1.00
15.95
A
C


ATOM
4831
O
ASP
A
304
32.728
4.260
10.544
1.00
16.02
A
O


ATOM
4833
N
GLU
A
305
34.373
4.338
12.085
1.00
16.25
A
N


ATOM
4834
CA
GLU
A
305
35.447
4.580
11.113
1.00
16.33
A
C


ATOM
4836
CB
GLU
A
305
36.755
4.941
11.827
1.00
16.05
A
C


ATOM
4839
CG
GLU
A
305
36.716
6.292
12.527
1.00
17.49
A
C


ATOM
4842
CD
GLU
A
305
37.971
6.589
13.330
1.00
19.41
A
C


ATOM
4843
OE1
GLU
A
305
38.649
5.636
13.773
1.00
21.25
A
O


ATOM
4844
OE2
GLU
A
305
38.274
7.785
13.524
1.00
19.58
A
O


ATOM
4845
C
GLU
A
305
35.667
3.364
10.215
1.00
16.21
A
C


ATOM
4846
O
GLU
A
305
35.798
3.499
8.996
1.00
16.05
A
O


ATOM
4848
N
LEU
A
306
35.699
2.183
10.829
1.00
16.16
A
N


ATOM
4849
CA
LEU
A
306
35.911
0.930
10.107
1.00
15.88
A
C


ATOM
4851
CB
LEU
A
306
36.033
−0.235
11.089
1.00
15.78
A
C


ATOM
4854
CG
LEU
A
306
37.274
−0.232
11.976
1.00
15.34
A
C


ATOM
4856
CD1
LEU
A
306
37.218
−1.417
12.928
1.00
16.17
A
C


ATOM
4860
CD2
LEU
A
306
38.541
−0.256
11.134
1.00
14.22
A
C


ATOM
4864
C
LEU
A
306
34.799
0.635
9.104
1.00
16.02
A
C


ATOM
4865
O
LEU
A
306
35.065
0.112
8.019
1.00
15.90
A
O


ATOM
4867
N
GLU
A
307
33.561
0.960
9.471
1.00
16.02
A
N


ATOM
4868
CA
GLU
A
307
32.427
0.802
8.563
1.00
16.25
A
C


ATOM
4870
CB
GLU
A
307
31.130
1.274
9.224
1.00
16.45
A
C


ATOM
4873
CG
GLU
A
307
30.620
0.361
10.331
1.00
17.76
A
C


ATOM
4876
CD
GLU
A
307
29.869
−0.853
9.813
1.00
19.89
A
C


ATOM
4877
OE1
GLU
A
307
29.047
−1.399
10.580
1.00
22.93
A
O


ATOM
4878
OE2
GLU
A
307
30.093
−1.262
8.653
1.00
19.71
A
O


ATOM
4879
C
GLU
A
307
32.654
1.572
7.264
1.00
16.17
A
C


ATOM
4880
O
GLU
A
307
32.380
1.063
6.179
1.00
16.40
A
O


ATOM
4882
N
LEU
A
308
33.163
2.795
7.383
1.00
16.07
A
N


ATOM
4883
CA
LEU
A
308
33.456
3.620
6.213
1.00
15.87
A
C


ATOM
4885
CB
LEU
A
308
33.850
5.038
6.634
1.00
15.51
A
C


ATOM
4888
CG
LEU
A
308
32.759
5.841
7.341
1.00
14.36
A
C


ATOM
4890
CD1
LEU
A
308
33.340
7.117
7.928
1.00
14.78
A
C


ATOM
4894
CD2
LEU
A
308
31.618
6.151
6.386
1.00
12.42
A
C


ATOM
4898
C
LEU
A
308
34.559
2.995
5.359
1.00
15.95
A
C


ATOM
4899
O
LEU
A
308
34.422
2.896
4.140
1.00
16.08
A
O


ATOM
4901
N
PHE
A
309
35.644
2.566
5.997
1.00
15.86
A
N


ATOM
4902
CA
PHE
A
309
36.741
1.932
5.271
1.00
15.76
A
C


ATOM
4904
CB
PHE
A
309
37.879
1.539
6.213
1.00
15.23
A
C


ATOM
4907
CG
PHE
A
309
39.167
1.268
5.505
1.00
12.77
A
C


ATOM
4908
CD1
PHE
A
309
40.023
2.308
5.187
1.00
11.18
A
C


ATOM
4910
CE1
PHE
A
309
41.216
2.073
4.524
1.00
10.16
A
C


ATOM
4912
CZ
PHE
A
309
41.558
0.788
4.165
1.00
11.94
A
C


ATOM
4914
CE2
PHE
A
309
40.705
−0.265
4.470
1.00
12.78
A
C


ATOM
4916
CD2
PHE
A
309
39.515
−0.019
5.136
1.00
12.55
A
C


ATOM
4918
C
PHE
A
309
36.242
0.701
4.519
1.00
16.65
A
C


ATOM
4919
O
PHE
A
309
36.509
0.545
3.326
1.00
16.66
A
O


ATOM
4921
N
THR
A
310
35.515
−0.162
5.227
1.00
17.62
A
N


ATOM
4922
CA
THR
A
310
34.879
−1.337
4.626
1.00
18.17
A
C


ATOM
4924
CB
THR
A
310
33.943
−2.053
5.630
1.00
18.21
A
C


ATOM
4926
OG1
THR
A
310
34.678
−2.429
6.802
1.00
18.07
A
O


ATOM
4928
CG2
THR
A
310
33.321
−3.292
4.999
1.00
18.32
A
C


ATOM
4932
C
THR
A
310
34.057
−0.931
3.407
1.00
18.50
A
C


ATOM
4933
O
THR
A
310
34.199
−1.514
2.330
1.00
18.52
A
O


ATOM
4935
N
ASP
A
311
33.205
0.077
3.591
1.00
18.74
A
N


ATOM
4936
CA
ASP
A
311
32.368
0.609
2.515
1.00
18.56
A
C


ATOM
4938
CB
ASP
A
311
31.415
1.684
3.053
1.00
18.73
A
C


ATOM
4941
CG
ASP
A
311
30.562
2.306
1.966
1.00
19.68
A
C


ATOM
4942
OD1
ASP
A
311
29.867
1.552
1.252
1.00
21.03
A
O


ATOM
4943
OD2
ASP
A
311
30.591
3.548
1.824
1.00
20.12
A
O


ATOM
4944
C
ASP
A
311
33.221
1.186
1.389
1.00
17.98
A
C


ATOM
4945
O
ASP
A
311
32.919
0.981
0.218
1.00
17.81
A
O


ATOM
4947
N
ALA
A
312
34.288
1.895
1.754
1.00
17.60
A
N


ATOM
4948
CA
ALA
A
312
35.207
2.487
0.779
1.00
17.18
A
C


ATOM
4950
CB
ALA
A
312
36.287
3.290
1.493
1.00
17.04
A
C


ATOM
4954
C
ALA
A
312
35.840
1.431
−0.132
1.00
16.89
A
C


ATOM
4955
O
ALA
A
312
35.978
1.647
−1.336
1.00
16.28
A
O


ATOM
4957
N
VAL
A
313
36.215
0.292
0.446
1.00
17.08
A
N


ATOM
4958
CA
VAL
A
313
36.777
−0.819
−0.326
1.00
17.48
A
C


ATOM
4960
CB
VAL
A
313
37.595
−1.779
0.572
1.00
17.54
A
C


ATOM
4962
CG1
VAL
A
313
38.729
−1.027
1.260
1.00
17.32
A
C


ATOM
4966
CG2
VAL
A
313
38.156
−2.933
−0.239
1.00
17.14
A
C


ATOM
4970
C
VAL
A
313
35.686
−1.598
−1.076
1.00
17.77
A
C


ATOM
4971
O
VAL
A
313
35.932
−2.118
−2.164
1.00
17.70
A
O


ATOM
4973
N
GLU
A
314
34.486
−1.669
−0.501
1.00
18.26
A
N


ATOM
4974
CA
GLU
A
314
33.347
−2.332
−1.155
1.00
18.61
A
C


ATOM
4976
CB
GLU
A
314
32.125
−2.376
−0.229
1.00
18.86
A
C


ATOM
4979
CG
GLU
A
314
32.105
−3.539
0.747
1.00
20.58
A
C


ATOM
4982
CD
GLU
A
314
30.881
−3.524
1.649
1.00
24.15
A
C


ATOM
4983
OE1
GLU
A
314
30.876
−4.268
2.652
1.00
28.09
A
O


ATOM
4984
OE2
GLU
A
314
29.923
−2.771
1.361
1.00
24.84
A
O


ATOM
4985
C
GLU
A
314
32.929
−1.675
−2.470
1.00
18.45
A
C


ATOM
4986
O
GLU
A
314
32.453
−2.359
−3.375
1.00
18.12
A
O


ATOM
4988
N
ARG
A
315
33.089
−0.355
−2.563
1.00
18.81
A
N


ATOM
4989
CA
ARG
A
315
32.614
0.405
−3.724
1.00
19.28
A
C


ATOM
4991
CB
ARG
A
315
31.904
1.687
−3.276
1.00
19.73
A
C


ATOM
4994
CG
ARG
A
315
30.876
1.469
−2.149
1.00
22.35
A
C


ATOM
4997
CD
ARG
A
315
29.651
2.378
−2.247
1.00
25.41
A
C


ATOM
5000
NE
ARG
A
315
29.952
3.667
−2.867
1.00
29.17
A
N


ATOM
5002
CZ
ARG
A
315
30.616
4.665
−2.284
1.00
32.10
A
C


ATOM
5003
NH1
ARG
A
315
30.828
5.789
−2.961
1.00
33.11
A
N


ATOM
5006
NH2
ARG
A
315
31.072
4.555
−1.038
1.00
33.08
A
N


ATOM
5009
C
ARG
A
315
33.730
0.733
−4.717
1.00
18.91
A
C


ATOM
5010
O
ARG
A
315
33.484
0.805
−5.921
1.00
18.78
A
O


ATOM
5012
N
TRP
A
316
34.944
0.936
−4.209
1.00
18.94
A
N


ATOM
5013
CA
TRP
A
316
36.125
1.195
−5.046
1.00
18.73
A
C


ATOM
5015
CB
TRP
A
316
36.366
0.014
−6.002
1.00
18.53
A
C


ATOM
5018
CG
TRP
A
316
37.802
−0.166
−6.398
1.00
17.21
A
C


ATOM
5019
CD1
TRP
A
316
38.330
−0.036
−7.649
1.00
16.88
A
C


ATOM
5021
NE1
TRP
A
316
39.682
−0.275
−7.620
1.00
15.97
A
N


ATOM
5023
CE2
TRP
A
316
40.051
−0.566
−6.334
1.00
15.80
A
C


ATOM
5024
CD2
TRP
A
316
38.891
−0.507
−5.537
1.00
15.21
A
C


ATOM
5025
CE3
TRP
A
316
38.999
−0.766
−4.167
1.00
16.69
A
C


ATOM
5027
CZ3
TRP
A
316
40.245
−1.073
−3.643
1.00
17.30
A
C


ATOM
5029
CH2
TRP
A
316
41.381
−1.127
−4.464
1.00
17.99
A
C


ATOM
5031
CZ2
TRP
A
316
41.305
−0.873
−5.808
1.00
17.57
A
C


ATOM
5033
C
TRP
A
316
36.024
2.523
−5.818
1.00
18.77
A
C


ATOM
5034
O
TRP
A
316
36.569
2.660
−6.913
1.00
18.58
A
O


ATOM
5036
N
ASP
A
317
35.334
3.497
−5.229
1.00
19.02
A
N


ATOM
5037
CA
ASP
A
317
35.161
4.811
−5.835
1.00
19.48
A
C


ATOM
5039
CB
ASP
A
317
33.739
5.327
−5.573
1.00
19.49
A
C


ATOM
5042
CG
ASP
A
317
33.471
6.694
−6.199
1.00
19.09
A
C


ATOM
5043
OD1
ASP
A
317
34.201
7.099
−7.129
1.00
19.20
A
O


ATOM
5044
OD2
ASP
A
317
32.512
7.365
−5.758
1.00
17.19
A
O


ATOM
5045
C
ASP
A
317
36.202
5.767
−5.253
1.00
20.22
A
C


ATOM
5046
O
ASP
A
317
36.110
6.161
−4.088
1.00
20.57
A
O


ATOM
5048
N
VAL
A
318
37.188
6.135
−6.070
1.00
20.71
A
N


ATOM
5049
CA
VAL
A
318
38.276
7.016
−5.633
1.00
21.05
A
C


ATOM
5051
CB
VAL
A
318
39.423
7.038
−6.666
1.00
20.76
A
C


ATOM
5053
CG1
VAL
A
318
40.690
7.613
−6.053
1.00
20.64
A
C


ATOM
5057
CG2
VAL
A
318
39.017
7.812
−7.911
1.00
20.38
A
C


ATOM
5061
C
VAL
A
318
37.818
8.456
−5.370
1.00
21.99
A
C


ATOM
5062
O
VAL
A
318
38.528
9.222
−4.719
1.00
22.30
A
O


ATOM
5064
N
ASN
A
319
36.644
8.821
−5.885
1.00
22.84
A
N


ATOM
5065
CA
ASN
A
319
36.083
10.160
−5.684
1.00
23.25
A
C


ATOM
5067
CB
ASN
A
319
35.177
10.539
−6.862
1.00
23.24
A
C


ATOM
5070
CG
ASN
A
319
35.956
10.749
−8.159
1.00
23.11
A
C


ATOM
5071
OD1
ASN
A
319
36.802
11.643
−8.255
1.00
22.22
A
O


ATOM
5072
ND2
ASN
A
319
35.664
9.929
−9.166
1.00
20.47
A
N


ATOM
5075
C
ASN
A
319
35.323
10.305
−4.360
1.00
24.05
A
C


ATOM
5076
O
ASN
A
319
35.057
11.425
−3.924
1.00
24.48
A
O


ATOM
5078
N
ALA
A
320
34.978
9.180
−3.730
1.00
24.88
A
N


ATOM
5079
CA
ALA
A
320
34.347
9.180
−2.399
1.00
25.38
A
C


ATOM
5081
CB
ALA
A
320
33.373
8.017
−2.277
1.00
25.19
A
C


ATOM
5085
C
ALA
A
320
35.380
9.127
−1.261
1.00
25.94
A
C


ATOM
5086
O
ALA
A
320
35.010
9.092
−0.085
1.00
26.43
A
O


ATOM
5088
N
ILE
A
321
36.663
9.119
−1.624
1.00
26.12
A
N


ATOM
5089
CA
ILE
A
321
37.785
9.144
−0.674
1.00
26.16
A
C


ATOM
5091
CB
ILE
A
321
39.124
9.356
−1.440
1.00
26.28
A
C


ATOM
5093
CG1
ILE
A
321
40.336
9.088
−0.551
1.00
25.99
A
C


ATOM
5096
CD1
ILE
A
321
41.648
9.204
−1.300
1.00
25.33
A
C


ATOM
5100
CG2
ILE
A
321
39.204
10.767
−2.021
1.00
27.21
A
C


ATOM
5104
C
ILE
A
321
37.651
10.218
0.420
1.00
26.28
A
C


ATOM
5105
O
ILE
A
321
38.083
10.002
1.553
1.00
26.33
A
O


ATOM
5107
N
ASN
A
322
37.046
11.361
0.078
1.00
26.31
A
N


ATOM
5108
CA
ASN
A
322
36.870
12.485
1.019
1.00
26.01
A
C


ATOM
5110
CB
ASN
A
322
36.659
13.804
0.248
1.00
25.94
A
C


ATOM
5113
CG
ASN
A
322
37.960
14.409
−0.261
1.00
26.56
A
C


ATOM
5114
OD1
ASN
A
322
39.043
14.120
0.251
1.00
26.84
A
O


ATOM
5115
ND2
ASN
A
322
37.854
15.266
−1.268
1.00
27.80
A
N


ATOM
5118
C
ASN
A
322
35.751
12.310
2.062
1.00
25.35
A
C


ATOM
5119
O
ASN
A
322
35.438
13.253
2.796
1.00
25.20
A
O


ATOM
5121
N
ASP
A
323
35.153
11.120
2.126
1.00
24.45
A
N


ATOM
5122
CA
ASP
A
323
34.220
10.778
3.204
1.00
24.14
A
C


ATOM
5124
CB
ASP
A
323
33.119
9.836
2.692
1.00
24.89
A
C


ATOM
5127
CG
ASP
A
323
32.096
10.547
1.811
1.00
26.83
A
C


ATOM
5128
OD1
ASP
A
323
31.426
11.480
2.306
1.00
27.88
A
O


ATOM
5129
OD2
ASP
A
323
31.952
10.162
0.629
1.00
29.53
A
O


ATOM
5130
C
ASP
A
323
34.945
10.136
4.394
1.00
22.55
A
C


ATOM
5131
O
ASP
A
323
34.408
10.098
5.504
1.00
22.17
A
O


ATOM
5133
N
LEU
A
324
36.162
9.644
4.157
1.00
21.03
A
N


ATOM
5134
CA
LEU
A
324
36.939
8.936
5.178
1.00
20.05
A
C


ATOM
5136
CB
LEU
A
324
37.933
7.973
4.518
1.00
19.99
A
C


ATOM
5139
CG
LEU
A
324
37.351
6.752
3.803
1.00
20.17
A
C


ATOM
5141
CD1
LEU
A
324
38.422
6.076
2.962
1.00
20.22
A
C


ATOM
5145
CD2
LEU
A
324
36.747
5.771
4.797
1.00
19.25
A
C


ATOM
5149
C
LEU
A
324
37.707
9.901
6.075
1.00
19.03
A
C


ATOM
5150
O
LEU
A
324
37.918
11.052
5.702
1.00
18.72
A
O


ATOM
5152
N
PRO
A
325
38.130
9.429
7.263
1.00
18.44
A
N


ATOM
5153
CA
PRO
A
325
39.010
10.213
8.122
1.00
18.19
A
C


ATOM
5155
CB
PRO
A
325
38.874
9.527
9.482
1.00
18.12
A
C


ATOM
5158
CG
PRO
A
325
38.558
8.121
9.159
1.00
18.05
A
C


ATOM
5161
CD
PRO
A
325
37.746
8.152
7.896
1.00
18.53
A
C


ATOM
5164
C
PRO
A
325
40.458
10.173
7.630
1.00
18.23
A
C


ATOM
5165
O
PRO
A
325
40.863
9.215
6.973
1.00
17.90
A
O


ATOM
5166
N
ASP
A
326
41.223
11.206
7.971
1.00
18.42
A
N


ATOM
5167
CA
ASP
A
326
42.555
11.441
7.400
1.00
18.51
A
C


ATOM
5169
CB
ASP
A
326
43.261
12.572
8.161
1.00
18.74
A
C


ATOM
5172
CG
ASP
A
326
42.691
13.945
7.832
1.00
20.90
A
C


ATOM
5173
OD1
ASP
A
326
42.044
14.087
6.772
1.00
23.65
A
O


ATOM
5174
OD2
ASP
A
326
42.891
14.886
8.632
1.00
23.58
A
O


ATOM
5175
C
ASP
A
326
43.466
10.209
7.307
1.00
18.04
A
C


ATOM
5176
O
ASP
A
326
44.037
9.950
6.246
1.00
18.16
A
O


ATOM
5178
N
TYR
A
327
43.605
9.453
8.393
1.00
17.28
A
N


ATOM
5179
CA
TYR
A
327
44.502
8.291
8.389
1.00
16.66
A
C


ATOM
5181
CB
TYR
A
327
44.728
7.753
9.807
1.00
16.33
A
C


ATOM
5184
CG
TYR
A
327
43.607
6.900
10.353
1.00
14.83
A
C


ATOM
5185
CD1
TYR
A
327
42.558
7.471
11.061
1.00
14.91
A
C


ATOM
5187
CE1
TYR
A
327
41.528
6.692
11.572
1.00
15.33
A
C


ATOM
5189
CZ
TYR
A
327
41.546
5.323
11.382
1.00
15.64
A
C


ATOM
5190
OH
TYR
A
327
40.524
4.554
11.893
1.00
15.59
A
O


ATOM
5192
CE2
TYR
A
327
42.585
4.729
10.683
1.00
14.60
A
C


ATOM
5194
CD2
TYR
A
327
43.607
5.518
10.176
1.00
13.91
A
C


ATOM
5196
C
TYR
A
327
44.004
7.180
7.454
1.00
16.77
A
C


ATOM
5197
O
TYR
A
327
44.801
6.394
6.934
1.00
16.95
A
O


ATOM
5199
N
MET
A
328
42.690
7.122
7.246
1.00
16.36
A
N


ATOM
5200
CA
MET
A
328
42.100
6.171
6.307
1.00
16.03
A
C


ATOM
5202
CB
MET
A
328
40.650
5.876
6.684
1.00
15.85
A
C


ATOM
5205
CG
MET
A
328
40.515
5.126
7.990
1.00
15.27
A
C


ATOM
5208
SD
MET
A
328
38.824
4.621
8.325
1.00
14.96
A
S


ATOM
5209
CE
MET
A
328
39.096
3.214
9.397
1.00
11.58
A
C


ATOM
5213
C
MET
A
328
42.171
6.665
4.862
1.00
16.28
A
C


ATOM
5214
O
MET
A
328
42.190
5.857
3.938
1.00
16.32
A
O


ATOM
5216
N
LYS
A
329
42.199
7.982
4.662
1.00
16.61
A
N


ATOM
5217
CA
LYS
A
329
42.364
8.542
3.320
1.00
16.78
A
C


ATOM
5219
CB
LYS
A
329
42.319
10.076
3.338
1.00
16.88
A
C


ATOM
5222
CG
LYS
A
329
40.977
10.672
3.743
1.00
19.25
A
C


ATOM
5225
CD
LYS
A
329
41.066
12.184
3.989
1.00
22.20
A
C


ATOM
5228
CE
LYS
A
329
40.917
12.990
2.701
1.00
23.60
A
C


ATOM
5231
NZ
LYS
A
329
41.054
14.461
2.934
1.00
23.47
A
N


ATOM
5235
C
LYS
A
329
43.699
8.076
2.752
1.00
16.51
A
C


ATOM
5236
O
LYS
A
329
43.750
7.459
1.687
1.00
16.65
A
O


ATOM
5238
N
LEU
A
330
44.770
8.355
3.492
1.00
16.06
A
N


ATOM
5239
CA
LEU
A
330
46.125
7.989
3.088
1.00
15.49
A
C


ATOM
5241
CB
LEU
A
330
47.142
8.516
4.110
1.00
15.41
A
C


ATOM
5244
CG
LEU
A
330
48.628
8.299
3.810
1.00
14.76
A
C


ATOM
5246
CD1
LEU
A
330
49.024
8.972
2.505
1.00
13.80
A
C


ATOM
5250
CD2
LEU
A
330
49.481
8.812
4.960
1.00
13.92
A
C


ATOM
5254
C
LEU
A
330
46.283
6.478
2.927
1.00
15.10
A
C


ATOM
5255
O
LEU
A
330
47.011
6.020
2.049
1.00
14.96
A
O


ATOM
5257
N
CYS
A
331
45.600
5.710
3.772
1.00
14.87
A
N


ATOM
5258
CA
CYS
A
331
45.696
4.248
3.732
1.00
14.79
A
C


ATOM
5260
CB
CYS
A
331
45.193
3.642
5.047
1.00
15.05
A
C


ATOM
5263
SG
CYS
A
331
45.475
1.867
5.196
1.00
16.22
A
S


ATOM
5265
C
CYS
A
331
44.919
3.661
2.552
1.00
13.61
A
C


ATOM
5266
O
CYS
A
331
45.455
2.861
1.787
1.00
13.77
A
O


ATOM
5268
N
PHE
A
332
43.661
4.067
2.415
1.00
12.37
A
N


ATOM
5269
CA
PHE
A
332
42.796
3.589
1.339
1.00
11.68
A
C


ATOM
5271
CB
PHE
A
332
41.430
4.282
1.415
1.00
11.85
A
C


ATOM
5274
CG
PHE
A
332
40.527
3.977
0.255
1.00
10.54
A
C


ATOM
5275
CD1
PHE
A
332
39.892
2.752
0.163
1.00
9.36
A
C


ATOM
5277
CE1
PHE
A
332
39.065
2.466
−0.905
1.00
11.01
A
C


ATOM
5279
CZ
PHE
A
332
38.862
3.413
−1.897
1.00
11.31
A
C


ATOM
5281
CE2
PHE
A
332
39.489
4.639
−1.815
1.00
9.89
A
C


ATOM
5283
CD2
PHE
A
332
40.315
4.917
−0.744
1.00
10.03
A
C


ATOM
5285
C
PHE
A
332
43.413
3.812
−0.042
1.00
11.23
A
C


ATOM
5286
O
PHE
A
332
43.527
2.878
−0.832
1.00
11.12
A
O


ATOM
5288
N
LEU
A
333
43.808
5.051
−0.322
1.00
10.61
A
N


ATOM
5289
CA
LEU
A
333
44.354
5.417
−1.632
1.00
10.12
A
C


ATOM
5291
CB
LEU
A
333
44.677
6.916
−1.680
1.00
9.81
A
C


ATOM
5294
CG
LEU
A
333
45.111
7.515
−3.022
1.00
8.38
A
C


ATOM
5296
CD1
LEU
A
333
44.113
7.206
−4.128
1.00
7.03
A
C


ATOM
5300
CD2
LEU
A
333
45.299
9.017
−2.881
1.00
5.80
A
C


ATOM
5304
C
LEU
A
333
45.598
4.605
−1.978
1.00
10.21
A
C


ATOM
5305
O
LEU
A
333
45.791
4.229
−3.133
1.00
9.84
A
O


ATOM
5307
N
ALA
A
334
46.432
4.342
−0.972
1.00
10.86
A
N


ATOM
5308
CA
ALA
A
334
47.645
3.538
−1.140
1.00
11.33
A
C


ATOM
5310
CB
ALA
A
334
48.442
3.504
0.155
1.00
11.25
A
C


ATOM
5314
C
ALA
A
334
47.302
2.120
−1.582
1.00
11.86
A
C


ATOM
5315
O
ALA
A
334
47.965
1.552
−2.453
1.00
11.99
A
O


ATOM
5317
N
LEU
A
335
46.273
1.552
−0.961
1.00
12.36
A
N


ATOM
5318
CA
LEU
A
335
45.726
0.262
−1.371
1.00
12.61
A
C


ATOM
5320
CB
LEU
A
335
44.651
−0.193
−0.375
1.00
12.56
A
C


ATOM
5323
CG
LEU
A
335
43.849
−1.461
−0.677
1.00
12.43
A
C


ATOM
5325
CD1
LEU
A
335
44.764
−2.659
−0.871
1.00
13.39
A
C


ATOM
5329
CD2
LEU
A
335
42.863
−1.712
0.447
1.00
9.98
A
C


ATOM
5333
C
LEU
A
335
45.136
0.383
−2.772
1.00
12.75
A
C


ATOM
5334
O
LEU
A
335
45.446
−0.411
−3.655
1.00
12.66
A
O


ATOM
5336
N
TYR
A
336
44.300
1.400
−2.961
1.00
13.37
A
N


ATOM
5337
CA
TYR
A
336
43.602
1.636
−4.225
1.00
13.86
A
C


ATOM
5339
CB
TYR
A
336
42.847
2.970
−4.167
1.00
14.27
A
C


ATOM
5342
CG
TYR
A
336
41.953
3.234
−5.357
1.00
14.40
A
C


ATOM
5343
CD1
TYR
A
336
40.743
2.569
−5.499
1.00
14.78
A
C


ATOM
5345
CE1
TYR
A
336
39.916
2.810
−6.586
1.00
13.90
A
C


ATOM
5347
CZ
TYR
A
336
40.293
3.725
−7.545
1.00
11.73
A
C


ATOM
5348
OH
TYR
A
336
39.473
3.962
−8.623
1.00
8.69
A
O


ATOM
5350
CE2
TYR
A
336
41.488
4.405
−7.423
1.00
13.24
A
C


ATOM
5352
CD2
TYR
A
336
42.310
4.158
−6.334
1.00
14.34
A
C


ATOM
5354
C
TYR
A
336
44.548
1.622
−5.422
1.00
13.95
A
C


ATOM
5355
O
TYR
A
336
44.305
0.907
−6.397
1.00
14.01
A
O


ATOM
5357
N
ASN
A
337
45.624
2.405
−5.332
1.00
13.83
A
N


ATOM
5358
CA
ASN
A
337
46.605
2.519
−6.416
1.00
13.77
A
C


ATOM
5360
CB
ASN
A
337
47.606
3.646
−6.127
1.00
13.87
A
C


ATOM
5363
CG
ASN
A
337
47.035
5.023
−6.408
1.00
15.61
A
C


ATOM
5364
OD1
ASN
A
337
46.144
5.179
−7.243
1.00
19.22
A
O


ATOM
5365
ND2
ASN
A
337
47.557
6.035
−5.719
1.00
16.23
A
N


ATOM
5368
C
ASN
A
337
47.362
1.221
−6.689
1.00
13.58
A
C


ATOM
5369
O
ASN
A
337
47.512
0.822
−7.841
1.00
13.59
A
O


ATOM
5371
N
THR
A
338
47.831
0.565
−5.631
1.00
13.35
A
N


ATOM
5372
CA
THR
A
338
48.600
−0.674
−5.770
1.00
13.08
A
C


ATOM
5374
CB
THR
A
338
49.056
−1.211
−4.399
1.00
12.97
A
C


ATOM
5376
OG1
THR
A
338
49.664
−0.156
−3.645
1.00
11.42
A
O


ATOM
5378
CG2
THR
A
338
50.053
−2.343
−4.574
1.00
13.23
A
C


ATOM
5382
C
THR
A
338
47.803
−1.766
−6.487
1.00
13.11
A
C


ATOM
5383
O
THR
A
338
48.347
−2.490
−7.321
1.00
12.90
A
O


ATOM
5385
N
ILE
A
339
46.515
−1.867
−6.163
1.00
13.33
A
N


ATOM
5386
CA
ILE
A
339
45.632
−2.852
−6.786
1.00
13.78
A
C


ATOM
5388
CB
ILE
A
339
44.286
−2.979
−6.033
1.00
13.62
A
C


ATOM
5390
CG1
ILE
A
339
44.507
−3.429
−4.585
1.00
13.37
A
C


ATOM
5393
CD1
ILE
A
339
45.261
−4.721
−4.450
1.00
11.21
A
C


ATOM
5397
CG2
ILE
A
339
43.364
−3.962
−6.740
1.00
13.25
A
C


ATOM
5401
C
ILE
A
339
45.356
−2.486
−8.242
1.00
14.51
A
C


ATOM
5402
O
ILE
A
339
45.444
−3.338
−9.127
1.00
14.76
A
O


ATOM
5404
N
ASN
A
340
45.025
−1.220
−8.485
1.00
15.03
A
N


ATOM
5405
CA
ASN
A
340
44.810
−0.734
−9.847
1.00
15.47
A
C


ATOM
5407
CB
ASN
A
340
44.412
0.741
−9.843
1.00
15.26
A
C


ATOM
5410
CG
ASN
A
340
43.012
0.971
−9.315
1.00
15.69
A
C


ATOM
5411
OD1
ASN
A
340
42.256
0.030
−9.065
1.00
14.77
A
O


ATOM
5412
ND2
ASN
A
340
42.656
2.236
−9.149
1.00
17.78
A
N


ATOM
5415
C
ASN
A
340
46.030
−0.918
−10.745
1.00
16.40
A
C


ATOM
5416
O
ASN
A
340
45.882
−1.126
−11.950
1.00
17.11
A
O


ATOM
5418
N
GLU
A
341
47.227
−0.839
−10.161
1.00
16.74
A
N


ATOM
5419
CA
GLU
A
341
48.467
−1.016
−10.919
1.00
16.76
A
C


ATOM
5421
CB
GLU
A
341
49.645
−0.371
−10.193
1.00
17.38
A
C


ATOM
5424
CG
GLU
A
341
49.525
1.142
−10.115
1.00
20.36
A
C


ATOM
5427
CD
GLU
A
341
50.747
1.812
−9.519
1.00
25.20
A
C


ATOM
5428
OE1
GLU
A
341
51.715
1.100
−9.164
1.00
27.46
A
O


ATOM
5429
OE2
GLU
A
341
50.731
3.061
−9.411
1.00
26.48
A
O


ATOM
5430
C
GLU
A
341
48.765
−2.480
−11.232
1.00
15.62
A
C


ATOM
5431
O
GLU
A
341
49.288
−2.782
−12.305
1.00
15.57
A
O


ATOM
5433
N
ILE
A
342
48.439
−3.390
−10.316
1.00
14.59
A
N


ATOM
5434
CA
ILE
A
342
48.519
−4.819
−10.637
1.00
14.45
A
C


ATOM
5436
CB
ILE
A
342
48.289
−5.731
−9.410
1.00
14.11
A
C


ATOM
5438
CG1
ILE
A
342
49.421
−5.570
−8.398
1.00
14.65
A
C


ATOM
5441
CD1
ILE
A
342
49.239
−6.395
−7.145
1.00
14.72
A
C


ATOM
5445
CG2
ILE
A
342
48.233
−7.189
−9.837
1.00
13.46
A
C


ATOM
5449
C
ILE
A
342
47.490
−5.145
−11.724
1.00
14.17
A
C


ATOM
5450
O
ILE
A
342
47.784
−5.884
−12.668
1.00
14.44
A
O


ATOM
5452
N
ALA
A
343
46.293
−4.576
−11.586
1.00
13.41
A
N


ATOM
5453
CA
ALA
A
343
45.229
−4.730
−12.577
1.00
12.37
A
C


ATOM
5455
CB
ALA
A
343
43.979
−3.989
−12.127
1.00
12.12
A
C


ATOM
5459
C
ALA
A
343
45.671
−4.234
−13.952
1.00
11.86
A
C


ATOM
5460
O
ALA
A
343
45.270
−4.793
−14.971
1.00
11.95
A
O


ATOM
5462
N
TYR
A
344
46.491
−3.182
−13.974
1.00
11.28
A
N


ATOM
5463
CA
TYR
A
344
47.076
−2.685
−15.219
1.00
10.66
A
C


ATOM
5465
CB
TYR
A
344
47.703
−1.298
−15.027
1.00
10.43
A
C


ATOM
5468
CG
TYR
A
344
48.443
−0.803
−16.250
1.00
8.34
A
C


ATOM
5469
CD1
TYR
A
344
47.782
−0.096
−17.248
1.00
6.31
A
C


ATOM
5471
CE1
TYR
A
344
48.453
0.350
−18.377
1.00
5.53
A
C


ATOM
5473
CZ
TYR
A
344
49.802
0.088
−18.520
1.00
6.31
A
C


ATOM
5474
OH
TYR
A
344
50.471
0.530
−19.638
1.00
4.56
A
O


ATOM
5476
CE2
TYR
A
344
50.482
−0.614
−17.542
1.00
7.74
A
C


ATOM
5478
CD2
TYR
A
344
49.801
−1.056
−16.416
1.00
7.79
A
C


ATOM
5480
C
TYR
A
344
48.124
−3.666
−15.725
1.00
10.67
A
C


ATOM
5481
O
TYR
A
344
48.084
−4.078
−16.881
1.00
10.32
A
O


ATOM
5483
N
ASP
A
345
49.060
−4.033
−14.853
1.00
11.33
A
N


ATOM
5484
CA
ASP
A
345
50.108
−5.004
−15.192
1.00
11.99
A
C


ATOM
5486
CB
ASP
A
345
50.939
−5.377
−13.948
1.00
12.01
A
C


ATOM
5489
CG
ASP
A
345
51.945
−4.297
−13.553
1.00
12.59
A
C


ATOM
5490
OD1
ASP
A
345
52.076
−3.277
−14.269
1.00
11.18
A
O


ATOM
5491
OD2
ASP
A
345
52.615
−4.483
−12.513
1.00
12.55
A
O


ATOM
5492
C
ASP
A
345
49.530
−6.275
−15.829
1.00
11.93
A
C


ATOM
5493
O
ASP
A
345
50.123
−6.833
−16.758
1.00
11.83
A
O


ATOM
5495
N
ASN
A
346
48.378
−6.722
−15.329
1.00
11.62
A
N


ATOM
5496
CA
ASN
A
346
47.709
−7.906
−15.868
1.00
11.58
A
C


ATOM
5498
CB
ASN
A
346
46.774
−8.521
−14.825
1.00
11.15
A
C


ATOM
5501
CG
ASN
A
346
47.516
−9.376
−13.819
1.00
12.26
A
C


ATOM
5502
OD1
ASN
A
346
48.097
−10.404
−14.173
1.00
14.81
A
O


ATOM
5503
ND2
ASN
A
346
47.502
−8.961
−12.557
1.00
12.75
A
N


ATOM
5506
C
ASN
A
346
46.956
−7.634
−17.171
1.00
11.92
A
C


ATOM
5507
O
ASN
A
346
46.898
−8.503
−18.041
1.00
12.36
A
O


ATOM
5509
N
LEU
A
347
46.384
−6.440
−17.311
1.00
11.92
A
N


ATOM
5510
CA
LEU
A
347
45.734
−6.057
−18.566
1.00
11.64
A
C


ATOM
5512
CB
LEU
A
347
44.961
−4.740
−18.413
1.00
11.58
A
C


ATOM
5515
CG
LEU
A
347
44.059
−4.336
−19.588
1.00
10.95
A
C


ATOM
5517
CD1
LEU
A
347
42.907
−5.312
−19.745
1.00
10.27
A
C


ATOM
5521
CD2
LEU
A
347
43.533
−2.919
−19.413
1.00
9.70
A
C


ATOM
5525
C
LEU
A
347
46.772
−5.936
−19.680
1.00
11.59
A
C


ATOM
5526
O
LEU
A
347
46.514
−6.330
−20.814
1.00
11.64
A
O


ATOM
5528
N
LYS
A
348
47.946
−5.405
−19.348
1.00
11.60
A
N


ATOM
5529
CA
LYS
A
348
49.022
−5.244
−20.321
1.00
11.67
A
C


ATOM
5531
CB
LYS
A
348
50.169
−4.411
−19.731
1.00
11.61
A
C


ATOM
5534
CG
LYS
A
348
51.223
−4.009
−20.758
1.00
12.03
A
C


ATOM
5537
CD
LYS
A
348
52.290
−3.072
−20.194
1.00
12.25
A
C


ATOM
5540
CE
LYS
A
348
53.520
−3.809
−19.672
1.00
12.33
A
C


ATOM
5543
NZ
LYS
A
348
53.341
−4.292
−18.278
1.00
14.05
A
N


ATOM
5547
C
LYS
A
348
49.558
−6.595
−20.794
1.00
11.72
A
C


ATOM
5548
O
LYS
A
348
49.582
−6.876
−21.990
1.00
11.62
A
O


ATOM
5550
N
ASP
A
349
49.969
−7.430
−19.847
1.00
12.09
A
N


ATOM
5551
CA
ASP
A
349
50.714
−8.650
−20.162
1.00
12.80
A
C


ATOM
5553
CB
ASP
A
349
51.664
−8.986
−19.006
1.00
13.12
A
C


ATOM
5556
CG
ASP
A
349
52.656
−7.862
−18.717
1.00
14.20
A
C


ATOM
5557
OD1
ASP
A
349
52.969
−7.085
−19.650
1.00
11.97
A
O


ATOM
5558
OD2
ASP
A
349
53.120
−7.756
−17.558
1.00
15.26
A
O


ATOM
5559
C
ASP
A
349
49.851
−9.873
−20.506
1.00
12.85
A
C


ATOM
5560
O
ASP
A
349
50.365
−10.840
−21.071
1.00
12.41
A
O


ATOM
5562
N
LYS
A
350
48.560
−9.833
−20.169
1.00
13.16
A
N


ATOM
5563
CA
LYS
A
350
47.635
−10.942
−20.471
1.00
13.31
A
C


ATOM
5565
CB
LYS
A
350
47.101
−11.564
−19.179
1.00
13.49
A
C


ATOM
5568
CG
LYS
A
350
48.180
−12.050
−18.233
1.00
15.19
A
C


ATOM
5571
CD
LYS
A
350
47.570
−12.759
−17.044
1.00
17.31
A
C


ATOM
5574
CE
LYS
A
350
48.620
−13.131
−16.015
1.00
17.74
A
C


ATOM
5577
NZ
LYS
A
350
47.980
−13.734
−14.818
1.00
17.79
A
N


ATOM
5581
C
LYS
A
350
46.451
−10.554
−21.358
1.00
12.84
A
C


ATOM
5582
O
LYS
A
350
45.896
−11.406
−22.048
1.00
12.55
A
O


ATOM
5584
N
GLY
A
351
46.056
−9.285
−21.331
1.00
13.03
A
N


ATOM
5585
CA
GLY
A
351
44.914
−8.816
−22.115
1.00
13.29
A
C


ATOM
5588
C
GLY
A
351
43.595
−9.148
−21.448
1.00
13.31
A
C


ATOM
5589
O
GLY
A
351
42.623
−9.491
−22.116
1.00
13.20
A
O


ATOM
5591
N
GLU
A
352
43.567
−9.047
−20.124
1.00
13.73
A
N


ATOM
5592
CA
GLU
A
352
42.388
−9.384
−19.342
1.00
14.52
A
C


ATOM
5594
CB
GLU
A
352
42.547
−10.770
−18.698
1.00
14.81
A
C


ATOM
5597
CG
GLU
A
352
42.906
−11.923
−19.656
1.00
15.61
A
C


ATOM
5600
CD
GLU
A
352
41.735
−12.422
−20.503
1.00
15.97
A
C


ATOM
5601
OE1
GLU
A
352
40.627
−11.845
−20.425
1.00
15.33
A
O


ATOM
5602
OE2
GLU
A
352
41.934
−13.408
−21.249
1.00
14.04
A
O


ATOM
5603
C
GLU
A
352
42.187
−8.335
−18.249
1.00
14.94
A
C


ATOM
5604
O
GLU
A
352
43.153
−7.891
−17.621
1.00
14.91
A
O


ATOM
5606
N
ASN
A
353
40.933
−7.944
−18.028
1.00
15.09
A
N


ATOM
5607
CA
ASN
A
353
40.579
−7.054
−16.924
1.00
15.05
A
C


ATOM
5609
CB
ASN
A
353
39.393
−6.167
−17.315
1.00
15.19
A
C


ATOM
5612
CG
ASN
A
353
39.132
−5.055
−16.314
1.00
14.51
A
C


ATOM
5613
OD1
ASN
A
353
39.523
−5.135
−15.151
1.00
12.06
A
O


ATOM
5614
ND2
ASN
A
353
38.459
−4.007
−16.769
1.00
16.67
A
N


ATOM
5617
C
ASN
A
353
40.238
−7.895
−15.696
1.00
14.95
A
C


ATOM
5618
O
ASN
A
353
39.198
−8.554
−15.662
1.00
15.14
A
O


ATOM
5620
N
ILE
A
354
41.118
−7.863
−14.695
1.00
14.71
A
N


ATOM
5621
CA
ILE
A
354
40.940
−8.652
−13.472
1.00
14.50
A
C


ATOM
5623
CB
ILE
A
354
42.138
−9.614
−13.238
1.00
14.70
A
C


ATOM
5625
CG1
ILE
A
354
43.430
−8.840
−12.954
1.00
14.73
A
C


ATOM
5628
CD1
ILE
A
354
44.527
−9.706
−12.397
1.00
13.59
A
C


ATOM
5632
CG2
ILE
A
354
42.333
−10.530
−14.441
1.00
15.18
A
C


ATOM
5636
C
ILE
A
354
40.736
−7.791
−12.221
1.00
14.26
A
C


ATOM
5637
O
ILE
A
354
40.839
−8.290
−11.104
1.00
14.39
A
O


ATOM
5639
N
LEU
A
355
40.440
−6.507
−12.401
1.00
14.54
A
N


ATOM
5640
CA
LEU
A
355
40.244
−5.601
−11.266
1.00
14.48
A
C


ATOM
5642
CB
LEU
A
355
40.026
−4.157
−11.748
1.00
14.01
A
C


ATOM
5645
CG
LEU
A
355
39.868
−3.068
−10.679
1.00
13.56
A
C


ATOM
5647
CD1
LEU
A
355
41.000
−3.113
−9.666
1.00
13.71
A
C


ATOM
5651
CD2
LEU
A
355
39.786
−1.687
−11.320
1.00
12.08
A
C


ATOM
5655
C
LEU
A
355
39.103
−6.042
−10.335
1.00
14.97
A
C


ATOM
5656
O
LEU
A
355
39.248
−5.951
−9.116
1.00
15.16
A
O


ATOM
5658
N
PRO
A
356
37.976
−6.532
−10.899
1.00
15.42
A
N


ATOM
5659
CA
PRO
A
356
36.863
−6.986
−10.057
1.00
15.69
A
C


ATOM
5661
CB
PRO
A
356
35.785
−7.372
−11.079
1.00
15.69
A
C


ATOM
5664
CG
PRO
A
356
36.124
−6.623
−12.292
1.00
15.33
A
C


ATOM
5667
CD
PRO
A
356
37.610
−6.580
−12.326
1.00
15.51
A
C


ATOM
5670
C
PRO
A
356
37.177
−8.185
−9.154
1.00
15.96
A
C


ATOM
5671
O
PRO
A
356
36.545
−8.342
−8.107
1.00
16.29
A
O


ATOM
5672
N
TYR
A
357
38.130
−9.023
−9.556
1.00
15.86
A
N


ATOM
5673
CA
TYR
A
357
38.504
−10.198
−8.762
1.00
16.04
A
C


ATOM
5675
CB
TYR
A
357
39.099
−11.298
−9.651
1.00
16.10
A
C


ATOM
5678
CG
TYR
A
357
38.332
−11.505
−10.938
1.00
17.77
A
C


ATOM
5679
CD1
TYR
A
357
36.958
−11.732
−10.921
1.00
18.41
A
C


ATOM
5681
CE1
TYR
A
357
36.244
−11.912
−12.099
1.00
18.01
A
C


ATOM
5683
CZ
TYR
A
357
36.905
−11.864
−13.311
1.00
18.22
A
C


ATOM
5684
OH
TYR
A
357
36.207
−12.043
−14.479
1.00
19.76
A
O


ATOM
5686
CE2
TYR
A
357
38.269
−11.641
−13.356
1.00
18.63
A
C


ATOM
5688
CD2
TYR
A
357
38.975
−11.460
−12.173
1.00
18.68
A
C


ATOM
5690
C
TYR
A
357
39.489
−9.810
−7.661
1.00
15.60
A
C


ATOM
5691
O
TYR
A
357
39.448
−10.361
−6.562
1.00
15.71
A
O


ATOM
5693
N
LEU
A
358
40.371
−8.861
−7.965
1.00
15.17
A
N


ATOM
5694
CA
LEU
A
358
41.318
−8.345
−6.983
1.00
14.66
A
C


ATOM
5696
CB
LEU
A
358
42.383
−7.471
−7.655
1.00
14.49
A
C


ATOM
5699
CG
LEU
A
358
43.348
−8.179
−8.610
1.00
13.67
A
C


ATOM
5701
CD1
LEU
A
358
44.231
−7.165
−9.319
1.00
13.09
A
C


ATOM
5705
CD2
LEU
A
358
44.198
−9.197
−7.873
1.00
11.60
A
C


ATOM
5709
C
LEU
A
358
40.597
−7.548
−5.899
1.00
14.57
A
C


ATOM
5710
O
LEU
A
358
40.844
−7.764
−4.713
1.00
15.41
A
O


ATOM
5712
N
THR
A
359
39.703
−6.644
−6.304
1.00
13.71
A
N


ATOM
5713
CA
THR
A
359
39.002
−5.768
−5.354
1.00
13.19
A
C


ATOM
5715
CB
THR
A
359
38.347
−4.560
−6.058
1.00
13.29
A
C


ATOM
5717
OG1
THR
A
359
37.390
−5.020
−7.020
1.00
15.24
A
O


ATOM
5719
CG2
THR
A
359
39.399
−3.705
−6.748
1.00
12.12
A
C


ATOM
5723
C
THR
A
359
37.933
−6.490
−4.528
1.00
12.69
A
C


ATOM
5724
O
THR
A
359
37.545
−6.008
−3.464
1.00
12.15
A
O


ATOM
5726
N
LYS
A
360
37.456
−7.634
−5.019
1.00
12.46
A
N


ATOM
5727
CA
LYS
A
360
36.519
−8.471
−4.263
1.00
12.16
A
C


ATOM
5729
CB
LYS
A
360
35.845
−9.498
−5.180
1.00
12.44
A
C


ATOM
5732
CG
LYS
A
360
34.793
−10.378
−4.499
1.00
13.59
A
C


ATOM
5735
CD
LYS
A
360
33.591
−9.569
−4.027
1.00
14.74
A
C


ATOM
5738
CE
LYS
A
360
32.450
−10.472
−3.579
1.00
15.45
A
C


ATOM
5741
NZ
LYS
A
360
31.179
−9.724
−3.364
1.00
15.06
A
N


ATOM
5745
C
LYS
A
360
37.235
−9.185
−3.118
1.00
11.29
A
C


ATOM
5746
O
LYS
A
360
36.666
−9.365
−2.042
1.00
11.08
A
O


ATOM
5748
N
ALA
A
361
38.476
−9.598
−3.359
1.00
10.61
A
N


ATOM
5749
CA
ALA
A
361
39.304
−10.206
−2.318
1.00
10.70
A
C


ATOM
5751
CB
ALA
A
361
40.628
−10.673
−2.900
1.00
11.07
A
C


ATOM
5755
C
ALA
A
361
39.553
−9.222
−1.181
1.00
10.58
A
C


ATOM
5756
O
ALA
A
361
39.661
−9.619
−0.019
1.00
10.13
A
O


ATOM
5758
N
TRP
A
362
39.643
−7.941
−1.534
1.00
10.54
A
N


ATOM
5759
CA
TRP
A
362
39.859
−6.868
−0.568
1.00
10.37
A
C


ATOM
5761
CB
TRP
A
362
40.577
−5.696
−1.236
1.00
9.72
A
C


ATOM
5764
CG
TRP
A
362
42.045
−5.882
−1.233
1.00
9.03
A
C


ATOM
5765
CD1
TRP
A
362
42.838
−6.216
−2.288
1.00
9.07
A
C


ATOM
5767
NE1
TRP
A
362
44.147
−6.312
−1.883
1.00
8.13
A
N


ATOM
5769
CE2
TRP
A
362
44.215
−6.045
−0.542
1.00
7.66
A
C


ATOM
5770
CD2
TRP
A
362
42.907
−5.775
−0.099
1.00
7.66
A
C


ATOM
5771
CE3
TRP
A
362
42.699
−5.472
1.250
1.00
7.22
A
C


ATOM
5773
CZ3
TRP
A
362
43.784
−5.446
2.099
1.00
7.74
A
C


ATOM
5775
CH2
TRP
A
362
45.076
−5.718
1.629
1.00
9.54
A
C


ATOM
5777
CZ2
TRP
A
362
45.310
−6.018
0.314
1.00
9.02
A
C


ATOM
5779
C
TRP
A
362
38.570
−6.394
0.099
1.00
11.16
A
C


ATOM
5780
O
TRP
A
362
38.588
−6.007
1.267
1.00
11.42
A
O


ATOM
5782
N
ALA
A
363
37.462
−6.416
−0.639
1.00
11.67
A
N


ATOM
5783
CA
ALA
A
363
36.151
−6.099
−0.070
1.00
12.00
A
C


ATOM
5785
CB
ALA
A
363
35.103
−5.985
−1.169
1.00
11.90
A
C


ATOM
5789
C
ALA
A
363
35.738
−7.162
0.941
1.00
12.69
A
C


ATOM
5790
O
ALA
A
363
35.096
−6.857
1.944
1.00
12.73
A
O


ATOM
5792
N
ASP
A
364
36.112
−8.409
0.670
1.00
13.63
A
N


ATOM
5793
CA
ASP
A
364
35.763
−9.523
1.544
1.00
14.66
A
C


ATOM
5795
CB
ASP
A
364
35.734
−10.838
0.754
1.00
15.17
A
C


ATOM
5798
CG
ASP
A
364
34.559
−10.916
−0.223
1.00
17.28
A
C


ATOM
5799
OD1
ASP
A
364
33.578
−10.155
−0.061
1.00
17.21
A
O


ATOM
5800
OD2
ASP
A
364
34.618
−11.751
−1.154
1.00
20.88
A
O


ATOM
5801
C
ASP
A
364
36.711
−9.635
2.738
1.00
14.83
A
C


ATOM
5802
O
ASP
A
364
36.275
−9.968
3.841
1.00
15.19
A
O


ATOM
5804
N
LEU
A
365
37.998
−9.359
2.527
1.00
14.97
A
N


ATOM
5805
CA
LEU
A
365
38.978
−9.400
3.620
1.00
14.98
A
C


ATOM
5807
CB
LEU
A
365
40.399
−9.149
3.100
1.00
14.64
A
C


ATOM
5810
CG
LEU
A
365
41.521
−9.152
4.146
1.00
13.12
A
C


ATOM
5812
CD1
LEU
A
365
41.596
−10.491
4.852
1.00
12.43
A
C


ATOM
5816
CD2
LEU
A
365
42.861
−8.812
3.514
1.00
13.28
A
C


ATOM
5820
C
LEU
A
365
38.632
−8.367
4.685
1.00
15.67
A
C


ATOM
5821
O
LEU
A
365
38.742
−8.637
5.884
1.00
16.08
A
O


ATOM
5823
N
CYS
A
366
38.216
−7.187
4.234
1.00
16.03
A
N


ATOM
5824
CA
CYS
A
366
37.820
−6.108
5.130
1.00
16.51
A
C


ATOM
5826
CB
CYS
A
366
37.723
−4.784
4.363
1.00
16.60
A
C


ATOM
5829
SG
CYS
A
366
39.333
−4.159
3.767
1.00
17.69
A
S


ATOM
5831
C
CYS
A
366
36.505
−6.430
5.850
1.00
17.00
A
C


ATOM
5832
O
CYS
A
366
36.377
−6.170
7.047
1.00
17.59
A
O


ATOM
5834
N
ASN
A
367
35.541
−7.008
5.132
1.00
17.21
A
N


ATOM
5835
CA
ASN
A
367
34.291
−7.476
5.757
1.00
17.08
A
C


ATOM
5837
CB
ASN
A
367
33.275
−7.939
4.703
1.00
17.09
A
C


ATOM
5840
CG
ASN
A
367
32.260
−6.863
4.354
1.00
17.63
A
C


ATOM
5841
OD1
ASN
A
367
31.791
−6.127
5.225
1.00
17.70
A
O


ATOM
5842
ND2
ASN
A
367
31.903
−6.778
3.076
1.00
17.33
A
N


ATOM
5845
C
ASN
A
367
34.514
−8.590
6.782
1.00
17.07
A
C


ATOM
5846
O
ASN
A
367
33.684
−8.793
7.670
1.00
17.00
A
O


ATOM
5848
N
ALA
A
368
35.627
−9.311
6.646
1.00
16.97
A
N


ATOM
5849
CA
ALA
A
368
36.051
−10.287
7.647
1.00
16.97
A
C


ATOM
5851
CB
ALA
A
368
37.167
−11.156
7.093
1.00
16.96
A
C


ATOM
5855
C
ALA
A
368
36.505
−9.598
8.937
1.00
17.11
A
C


ATOM
5856
O
ALA
A
368
36.112
−10.006
10.034
1.00
16.89
A
O


ATOM
5858
N
PHE
A
369
37.332
−8.559
8.798
1.00
17.06
A
N


ATOM
5859
CA
PHE
A
369
37.834
−7.796
9.948
1.00
17.07
A
C


ATOM
5861
CB
PHE
A
369
38.876
−6.756
9.517
1.00
17.09
A
C


ATOM
5864
CG
PHE
A
369
40.163
−7.336
9.004
1.00
17.47
A
C


ATOM
5865
CD1
PHE
A
369
40.847
−8.307
9.722
1.00
19.16
A
C


ATOM
5867
CE1
PHE
A
369
42.047
−8.826
9.253
1.00
19.68
A
C


ATOM
5869
CZ
PHE
A
369
42.583
−8.361
8.064
1.00
19.22
A
C


ATOM
5871
CE2
PHE
A
369
41.917
−7.383
7.347
1.00
19.11
A
C


ATOM
5873
CD2
PHE
A
369
40.717
−6.872
7.820
1.00
17.84
A
C


ATOM
5875
C
PHE
A
369
36.721
−7.061
10.694
1.00
17.02
A
C


ATOM
5876
O
PHE
A
369
36.748
−6.961
11.924
1.00
17.17
A
O


ATOM
5878
N
LEU
A
370
35.763
−6.521
9.945
1.00
16.86
A
N


ATOM
5879
CA
LEU
A
370
34.624
−5.827
10.543
1.00
16.90
A
C


ATOM
5881
CB
LEU
A
370
33.710
−5.241
9.462
1.00
17.00
A
C


ATOM
5884
CG
LEU
A
370
32.790
−4.104
9.913
1.00
16.77
A
C


ATOM
5886
CD1
LEU
A
370
33.545
−2.782
9.908
1.00
17.03
A
C


ATOM
5890
CD2
LEU
A
370
31.557
−4.011
9.027
1.00
17.46
A
C


ATOM
5894
C
LEU
A
370
33.843
−6.802
11.415
1.00
17.08
A
C


ATOM
5895
O
LEU
A
370
33.438
−6.464
12.526
1.00
16.72
A
O


ATOM
5897
N
GLN
A
371
33.651
−8.016
10.899
1.00
17.46
A
N


ATOM
5898
CA
GLN
A
371
32.961
−9.077
11.626
1.00
17.49
A
C


ATOM
5900
CB
GLN
A
371
32.719
−10.279
10.708
1.00
17.34
A
C


ATOM
5903
CG
GLN
A
371
31.916
−11.410
11.344
1.00
17.48
A
C


ATOM
5906
CD
GLN
A
371
30.512
−10.990
11.732
1.00
17.14
A
C


ATOM
5907
OE1
GLN
A
371
30.267
−10.572
12.863
1.00
17.53
A
O


ATOM
5908
NE2
GLN
A
371
29.582
−11.091
10.789
1.00
16.59
A
N


ATOM
5911
C
GLN
A
371
33.741
−9.506
12.869
1.00
17.91
A
C


ATOM
5912
O
GLN
A
371
33.140
−9.800
13.901
1.00
18.11
A
O


ATOM
5914
N
GLU
A
372
35.070
−9.549
12.767
1.00
18.39
A
N


ATOM
5915
CA
GLU
A
372
35.926
−9.854
13.921
1.00
18.81
A
C


ATOM
5917
CB
GLU
A
372
37.388
−10.058
13.498
1.00
19.35
A
C


ATOM
5920
CG
GLU
A
372
37.707
−11.451
12.961
1.00
22.59
A
C


ATOM
5923
CD
GLU
A
372
39.205
−11.722
12.862
1.00
26.48
A
C


ATOM
5924
OE1
GLU
A
372
39.992
−10.748
12.800
1.00
29.10
A
O


ATOM
5925
OE2
GLU
A
372
39.594
−12.912
12.843
1.00
27.20
A
O


ATOM
5926
C
GLU
A
372
35.854
−8.752
14.976
1.00
18.32
A
C


ATOM
5927
O
GLU
A
372
35.775
−9.040
16.171
1.00
18.34
A
O


ATOM
5929
N
ALA
A
373
35.886
−7.497
14.528
1.00
17.77
A
N


ATOM
5930
CA
ALA
A
373
35.846
−6.347
15.429
1.00
17.52
A
C


ATOM
5932
CB
ALA
A
373
36.239
−5.085
14.685
1.00
17.47
A
C


ATOM
5936
C
ALA
A
373
34.472
−6.171
16.083
1.00
17.59
A
C


ATOM
5937
O
ALA
A
373
34.383
−5.819
17.259
1.00
17.52
A
O


ATOM
5939
N
LYS
A
374
33.408
−6.416
15.319
1.00
17.66
A
N


ATOM
5940
CA
LYS
A
374
32.037
−6.287
15.827
1.00
17.69
A
C


ATOM
5942
CB
LYS
A
374
31.016
−6.485
14.700
1.00
17.73
A
C


ATOM
5945
CG
LYS
A
374
30.781
−5.244
13.848
1.00
18.61
A
C


ATOM
5948
CD
LYS
A
374
29.872
−5.544
12.659
1.00
19.44
A
C


ATOM
5951
CE
LYS
A
374
29.505
−4.277
11.898
1.00
18.81
A
C


ATOM
5954
NZ
LYS
A
374
28.710
−4.565
10.673
1.00
18.02
A
N


ATOM
5958
C
LYS
A
374
31.735
−7.250
16.977
1.00
17.82
A
C


ATOM
5959
O
LYS
A
374
31.028
−6.884
17.917
1.00
17.93
A
O


ATOM
5961
N
TRP
A
375
32.260
−8.473
16.896
1.00
18.05
A
N


ATOM
5962
CA
TRP
A
375
32.132
−9.445
17.989
1.00
18.34
A
C


ATOM
5964
CB
TRP
A
375
32.660
−10.824
17.575
1.00
18.28
A
C


ATOM
5967
CG
TRP
A
375
31.847
−11.529
16.523
1.00
18.45
A
C


ATOM
5968
CD1
TRP
A
375
30.498
−11.446
16.328
1.00
19.67
A
C


ATOM
5970
NE1
TRP
A
375
30.119
−12.249
15.278
1.00
18.96
A
N


ATOM
5972
CE2
TRP
A
375
31.228
−12.882
14.782
1.00
17.60
A
C


ATOM
5973
CD2
TRP
A
375
32.336
−12.457
15.545
1.00
17.42
A
C


ATOM
5974
CE3
TRP
A
375
33.604
−12.962
15.235
1.00
17.04
A
C


ATOM
5976
CZ3
TRP
A
375
33.724
−13.861
14.186
1.00
17.20
A
C


ATOM
5978
CH2
TRP
A
375
32.602
−14.267
13.446
1.00
17.60
A
C


ATOM
5980
CZ2
TRP
A
375
31.350
−13.790
13.728
1.00
17.78
A
C


ATOM
5982
C
TRP
A
375
32.883
−8.983
19.241
1.00
18.75
A
C


ATOM
5983
O
TRP
A
375
32.402
−9.171
20.362
1.00
19.03
A
O


ATOM
5985
N
LEU
A
376
34.062
−8.392
19.041
1.00
18.64
A
N


ATOM
5986
CA
LEU
A
376
34.890
−7.907
20.147
1.00
18.48
A
C


ATOM
5988
CB
LEU
A
376
36.302
−7.572
19.650
1.00
18.65
A
C


ATOM
5991
CG
LEU
A
376
37.413
−7.399
20.697
1.00
20.28
A
C


ATOM
5993
CD1
LEU
A
376
38.775
−7.749
20.098
1.00
21.89
A
C


ATOM
5997
CD2
LEU
A
376
37.437
−5.986
21.285
1.00
20.91
A
C


ATOM
6001
C
LEU
A
376
34.257
−6.693
20.834
1.00
18.28
A
C


ATOM
6002
O
LEU
A
376
34.401
−6.525
22.046
1.00
18.58
A
O


ATOM
6004
N
TYR
A
377
33.559
−5.857
20.065
1.00
17.92
A
N


ATOM
6005
CA
TYR
A
377
32.851
−4.698
20.622
1.00
17.91
A
C


ATOM
6007
CB
TYR
A
377
32.456
−3.710
19.513
1.00
18.04
A
C


ATOM
6010
CG
TYR
A
377
31.758
−2.460
20.019
1.00
18.20
A
C


ATOM
6011
CD1
TYR
A
377
32.450
−1.505
20.762
1.00
19.47
A
C


ATOM
6013
CE1
TYR
A
377
31.817
−0.357
21.234
1.00
19.90
A
C


ATOM
6015
CZ
TYR
A
377
30.474
−0.154
20.961
1.00
20.89
A
C


ATOM
6016
OH
TYR
A
377
29.846
0.980
21.429
1.00
19.22
A
O


ATOM
6018
CE2
TYR
A
377
29.763
−1.090
20.223
1.00
20.13
A
C


ATOM
6020
CD2
TYR
A
377
30.409
−2.234
19.756
1.00
18.66
A
C


ATOM
6022
C
TYR
A
377
31.607
−5.126
21.408
1.00
17.54
A
C


ATOM
6023
O
TYR
A
377
31.403
−4.696
22.546
1.00
17.43
A
O


ATOM
6025
N
ASN
A
378
30.792
−5.984
20.797
1.00
17.04
A
N


ATOM
6026
CA
ASN
A
378
29.527
−6.421
21.392
1.00
16.71
A
C


ATOM
6028
CB
ASN
A
378
28.534
−6.789
20.287
1.00
16.56
A
C


ATOM
6031
CG
ASN
A
378
28.283
−5.644
19.323
1.00
16.15
A
C


ATOM
6032
OD1
ASN
A
378
27.985
−4.526
19.735
1.00
15.51
A
O


ATOM
6033
ND2
ASN
A
378
28.405
−5.920
18.031
1.00
16.34
A
N


ATOM
6036
C
ASN
A
378
29.675
−7.599
22.356
1.00
16.69
A
C


ATOM
6037
O
ASN
A
378
28.687
−8.058
22.932
1.00
16.54
A
O


ATOM
6039
N
LYS
A
379
30.905
−8.083
22.528
1.00
16.67
A
N


ATOM
6040
CA
LYS
A
379
31.188
−9.241
23.375
1.00
16.55
A
C


ATOM
6042
CB
LYS
A
379
31.047
−8.874
24.859
1.00
16.40
A
C


ATOM
6045
CG
LYS
A
379
32.158
−7.964
25.348
1.00
17.12
A
C


ATOM
6048
CD
LYS
A
379
31.853
−7.352
26.702
1.00
17.89
A
C


ATOM
6051
CE
LYS
A
379
33.029
−6.523
27.198
1.00
18.11
A
C


ATOM
6054
NZ
LYS
A
379
32.604
−5.464
28.151
1.00
19.23
A
N


ATOM
6058
C
LYS
A
379
30.305
−10.432
22.997
1.00
16.36
A
C


ATOM
6059
O
LYS
A
379
29.725
−11.093
23.859
1.00
17.03
A
O


ATOM
6061
N
SER
A
380
30.214
−10.691
21.695
1.00
15.82
A
N


ATOM
6062
CA
SER
A
380
29.447
−11.818
21.179
1.00
15.44
A
C


ATOM
6064
CB
SER
A
380
29.261
−11.686
19.667
1.00
15.30
A
C


ATOM
6067
OG
SER
A
380
28.738
−10.414
19.326
1.00
14.16
A
O


ATOM
6069
C
SER
A
380
30.171
−13.118
21.503
1.00
15.54
A
C


ATOM
6070
O
SER
A
380
31.377
−13.115
21.747
1.00
15.63
A
O


ATOM
6072
N
THR
A
381
29.433
−14.226
21.504
1.00
15.71
A
N


ATOM
6073
CA
THR
A
381
30.004
−15.538
21.812
1.00
16.14
A
C


ATOM
6075
CB
THR
A
381
29.483
−16.076
23.173
1.00
16.44
A
C


ATOM
6077
OG1
THR
A
381
28.057
−16.215
23.133
1.00
17.09
A
O


ATOM
6079
CG2
THR
A
381
29.863
−15.133
24.309
1.00
17.19
A
C


ATOM
6083
C
THR
A
381
29.694
−16.539
20.696
1.00
16.10
A
C


ATOM
6084
O
THR
A
381
29.099
−17.591
20.947
1.00
16.34
A
O


ATOM
6086
N
PRO
A
382
30.115
−16.223
19.456
1.00
16.07
A
N


ATOM
6087
CA
PRO
A
382
29.789
−17.060
18.297
1.00
16.17
A
C


ATOM
6089
CB
PRO
A
382
30.430
−16.303
17.131
1.00
16.16
A
C


ATOM
6092
CG
PRO
A
382
31.535
−15.532
17.747
1.00
15.98
A
C


ATOM
6095
CD
PRO
A
382
31.022
−15.120
19.086
1.00
16.01
A
C


ATOM
6098
C
PRO
A
382
30.369
−18.470
18.385
1.00
16.25
A
C


ATOM
6099
O
PRO
A
382
31.442
−18.665
18.963
1.00
16.33
A
O


ATOM
6100
N
THR
A
383
29.662
−19.439
17.807
1.00
16.20
A
N


ATOM
6101
CA
THR
A
383
30.120
−20.828
17.800
1.00
15.92
A
C


ATOM
6103
CB
THR
A
383
29.044
−21.794
17.251
1.00
15.85
A
C


ATOM
6105
OG1
THR
A
383
28.676
−21.409
15.920
1.00
14.24
A
O


ATOM
6107
CG2
THR
A
383
27.807
−21.793
18.147
1.00
15.69
A
C


ATOM
6111
C
THR
A
383
31.387
−20.962
16.964
1.00
15.82
A
C


ATOM
6112
O
THR
A
383
31.668
−20.120
16.111
1.00
15.84
A
O


ATOM
6114
N
PHE
A
384
32.148
−22.021
17.219
1.00
15.86
A
N


ATOM
6115
CA
PHE
A
384
33.401
−22.274
16.508
1.00
15.78
A
C


ATOM
6117
CB
PHE
A
384
33.909
−23.687
16.812
1.00
15.96
A
C


ATOM
6120
CG
PHE
A
384
35.097
−24.097
15.987
1.00
15.25
A
C


ATOM
6121
CD1
PHE
A
384
36.337
−23.510
16.195
1.00
15.45
A
C


ATOM
6123
CE1
PHE
A
384
37.439
−23.887
15.438
1.00
15.15
A
C


ATOM
6125
CZ
PHE
A
384
37.305
−24.858
14.464
1.00
14.65
A
C


ATOM
6127
CE2
PHE
A
384
36.072
−25.450
14.247
1.00
14.59
A
C


ATOM
6129
CD2
PHE
A
384
34.977
−25.070
15.007
1.00
14.05
A
C


ATOM
6131
C
PHE
A
384
33.251
−22.101
15.002
1.00
15.75
A
C


ATOM
6132
O
PHE
A
384
34.061
−21.426
14.371
1.00
15.67
A
O


ATOM
6134
N
ASP
A
385
32.206
−22.704
14.439
1.00
15.83
A
N


ATOM
6135
CA
ASP
A
385
31.997
−22.699
12.990
1.00
15.78
A
C


ATOM
6137
CB
ASP
A
385
30.956
−23.755
12.593
1.00
15.57
A
C


ATOM
6140
CG
ASP
A
385
31.473
−25.179
12.750
1.00
14.28
A
C


ATOM
6141
OD1
ASP
A
385
32.696
−25.397
12.644
1.00
14.47
A
O


ATOM
6142
OD2
ASP
A
385
30.656
−26.092
12.971
1.00
13.30
A
O


ATOM
6143
C
ASP
A
385
31.618
−21.329
12.420
1.00
16.22
A
C


ATOM
6144
O
ASP
A
385
31.727
−21.121
11.215
1.00
16.29
A
O


ATOM
6146
N
ASP
A
386
31.178
−20.403
13.272
1.00
17.06
A
N


ATOM
6147
CA
ASP
A
386
30.967
−19.011
12.854
1.00
18.04
A
C


ATOM
6149
CB
ASP
A
386
29.900
−18.310
13.711
1.00
18.36
A
C


ATOM
6152
CG
ASP
A
386
28.490
−18.461
13.146
1.00
19.49
A
C


ATOM
6153
OD1
ASP
A
386
28.242
−19.410
12.369
1.00
21.38
A
O


ATOM
6154
OD2
ASP
A
386
27.625
−17.625
13.489
1.00
18.48
A
O


ATOM
6155
C
ASP
A
386
32.271
−18.223
12.910
1.00
18.63
A
C


ATOM
6156
O
ASP
A
386
32.644
−17.582
11.930
1.00
19.56
A
O


ATOM
6158
N
TYR
A
387
32.962
−18.265
14.048
1.00
19.03
A
N


ATOM
6159
CA
TYR
A
387
34.237
−17.556
14.182
1.00
19.44
A
C


ATOM
6161
CB
TYR
A
387
34.793
−17.629
15.614
1.00
19.51
A
C


ATOM
6164
CG
TYR
A
387
36.142
−16.950
15.762
1.00
21.18
A
C


ATOM
6165
CD1
TYR
A
387
36.235
−15.576
15.975
1.00
22.72
A
C


ATOM
6167
CE1
TYR
A
387
37.476
−14.945
16.095
1.00
24.66
A
C


ATOM
6169
CZ
TYR
A
387
38.641
−15.695
15.996
1.00
25.02
A
C


ATOM
6170
OH
TYR
A
387
39.870
−15.084
16.116
1.00
24.90
A
O


ATOM
6172
CE2
TYR
A
387
38.573
−17.060
15.778
1.00
24.35
A
C


ATOM
6174
CD2
TYR
A
387
37.328
−17.680
15.661
1.00
23.39
A
C


ATOM
6176
C
TYR
A
387
35.273
−18.089
13.188
1.00
19.48
A
C


ATOM
6177
O
TYR
A
387
35.892
−17.311
12.462
1.00
19.69
A
O


ATOM
6179
N
PHE
A
388
35.451
−19.409
13.155
1.00
19.44
A
N


ATOM
6180
CA
PHE
A
388
36.464
−20.016
12.293
1.00
19.32
A
C


ATOM
6182
CB
PHE
A
388
36.682
−21.490
12.626
1.00
19.39
A
C


ATOM
6185
CG
PHE
A
388
37.829
−22.101
11.878
1.00
19.88
A
C


ATOM
6186
CD1
PHE
A
388
39.135
−21.824
12.251
1.00
19.14
A
C


ATOM
6188
CE1
PHE
A
388
40.201
−22.370
11.559
1.00
20.10
A
C


ATOM
6190
CZ
PHE
A
388
39.969
−23.199
10.470
1.00
20.36
A
C


ATOM
6192
CE2
PHE
A
388
38.669
−23.476
10.080
1.00
20.47
A
C


ATOM
6194
CD2
PHE
A
388
37.606
−22.924
10.780
1.00
20.61
A
C


ATOM
6196
C
PHE
A
388
36.131
−19.869
10.813
1.00
19.22
A
C


ATOM
6197
O
PHE
A
388
37.028
−19.679
9.995
1.00
19.09
A
O


ATOM
6199
N
GLY
A
389
34.851
−19.963
10.468
1.00
19.30
A
N


ATOM
6200
CA
GLY
A
389
34.411
−19.671
9.106
1.00
19.45
A
C


ATOM
6203
C
GLY
A
389
34.924
−18.310
8.665
1.00
19.46
A
C


ATOM
6204
O
GLY
A
389
35.561
−18.186
7.616
1.00
19.53
A
O


ATOM
6206
N
ASN
A
390
34.662
−17.297
9.491
1.00
19.12
A
N


ATOM
6207
CA
ASN
A
390
35.119
−15.931
9.238
1.00
18.83
A
C


ATOM
6209
CB
ASN
A
390
34.388
−14.955
10.163
1.00
18.64
A
C


ATOM
6212
CG
ASN
A
390
34.691
−13.505
9.836
1.00
18.88
A
C


ATOM
6213
OD1
ASN
A
390
34.151
−12.949
8.882
1.00
20.54
A
O


ATOM
6214
ND2
ASN
A
390
35.561
−12.887
10.627
1.00
17.01
A
N


ATOM
6217
C
ASN
A
390
36.630
−15.750
9.416
1.00
18.88
A
C


ATOM
6218
O
ASN
A
390
37.240
−14.918
8.742
1.00
19.57
A
O


ATOM
6220
N
ALA
A
391
37.225
−16.525
10.322
1.00
18.39
A
N


ATOM
6221
CA
ALA
A
391
38.636
−16.365
10.688
1.00
17.65
A
C


ATOM
6223
CB
ALA
A
391
38.977
−17.237
11.885
1.00
17.64
A
C


ATOM
6227
C
ALA
A
391
39.617
−16.635
9.547
1.00
17.17
A
C


ATOM
6228
O
ALA
A
391
40.541
−15.849
9.349
1.00
17.37
A
O


ATOM
6230
N
TRP
A
392
39.435
−17.727
8.801
1.00
16.59
A
N


ATOM
6231
CA
TRP
A
392
40.381
−18.048
7.718
1.00
16.35
A
C


ATOM
6233
CB
TRP
A
392
40.325
−19.525
7.281
1.00
16.37
A
C


ATOM
6236
CG
TRP
A
392
39.029
−20.021
6.712
1.00
17.82
A
C


ATOM
6237
CD1
TRP
A
392
38.089
−20.760
7.363
1.00
20.80
A
C


ATOM
6239
NE1
TRP
A
392
37.044
−21.053
6.522
1.00
21.26
A
N


ATOM
6241
CE2
TRP
A
392
37.303
−20.516
5.290
1.00
19.01
A
C


ATOM
6242
CD2
TRP
A
392
38.552
−19.864
5.369
1.00
18.29
A
C


ATOM
6243
CE3
TRP
A
392
39.050
−19.225
4.229
1.00
18.54
A
C


ATOM
6245
CZ3
TRP
A
392
38.297
−19.258
3.066
1.00
18.44
A
C


ATOM
6247
CH2
TRP
A
392
37.060
−19.914
3.021
1.00
18.84
A
C


ATOM
6249
CZ2
TRP
A
392
36.547
−20.547
4.120
1.00
18.75
A
C


ATOM
6251
C
TRP
A
392
40.272
−17.093
6.521
1.00
15.96
A
C


ATOM
6252
O
TRP
A
392
41.223
−16.957
5.754
1.00
15.58
A
O


ATOM
6254
N
LYS
A
393
39.131
−16.427
6.367
1.00
16.07
A
N


ATOM
6255
CA
LYS
A
393
39.018
−15.339
5.389
1.00
16.20
A
C


ATOM
6257
CB
LYS
A
393
37.556
−15.051
5.034
1.00
16.58
A
C


ATOM
6260
CG
LYS
A
393
36.893
−16.149
4.211
1.00
18.39
A
C


ATOM
6263
CD
LYS
A
393
35.609
−15.652
3.561
1.00
21.72
A
C


ATOM
6266
CE
LYS
A
393
34.704
−16.803
3.139
1.00
22.15
A
C


ATOM
6269
NZ
LYS
A
393
34.074
−17.470
4.313
1.00
22.61
A
N


ATOM
6273
C
LYS
A
393
39.699
−14.068
5.902
1.00
15.28
A
C


ATOM
6274
O
LYS
A
393
40.191
−13.264
5.108
1.00
15.25
A
O


ATOM
6276
N
SER
A
394
39.725
−13.891
7.223
1.00
14.19
A
N


ATOM
6277
CA
SER
A
394
40.438
−12.768
7.836
1.00
13.88
A
C


ATOM
6279
CB
SER
A
394
39.829
−12.405
9.194
1.00
13.76
A
C


ATOM
6282
OG
SER
A
394
40.198
−13.331
10.198
1.00
14.47
A
O


ATOM
6284
C
SER
A
394
41.938
−13.043
7.987
1.00
13.51
A
C


ATOM
6285
O
SER
A
394
42.696
−12.149
8.359
1.00
13.98
A
O


ATOM
6287
N
SER
A
395
42.363
−14.275
7.711
1.00
12.98
A
N


ATOM
6288
CA
SER
A
395
43.789
−14.608
7.665
1.00
12.09
A
C


ATOM
6290
CB
SER
A
395
43.987
−16.115
7.484
1.00
11.72
A
C


ATOM
6293
OG
SER
A
395
43.677
−16.517
6.160
1.00
9.17
A
O


ATOM
6295
C
SER
A
395
44.479
−13.873
6.520
1.00
11.88
A
C


ATOM
6296
O
SER
A
395
45.653
−13.530
6.620
1.00
12.00
A
O


ATOM
6298
N
SER
A
396
43.721
−13.637
5.446
1.00
11.56
A
N


ATOM
6299
CA
SER
A
396
44.212
−13.063
4.189
1.00
11.42
A
C


ATOM
6301
CB
SER
A
396
45.143
−11.858
4.416
1.00
11.41
A
C


ATOM
6304
OG
SER
A
396
46.494
−12.252
4.580
1.00
10.83
A
O


ATOM
6306
C
SER
A
396
44.887
−14.131
3.325
1.00
11.35
A
C


ATOM
6307
O
SER
A
396
45.498
−13.814
2.300
1.00
11.18
A
O


ATOM
6309
N
GLY
A
397
44.761
−15.392
3.740
1.00
11.18
A
N


ATOM
6310
CA
GLY
A
397
45.257
−16.523
2.966
1.00
11.19
A
C


ATOM
6313
C
GLY
A
397
44.591
−16.607
1.605
1.00
11.20
A
C


ATOM
6314
O
GLY
A
397
45.270
−16.806
0.596
1.00
11.77
A
O


ATOM
6316
N
PRO
A
398
43.254
−16.458
1.565
1.00
10.58
A
N


ATOM
6317
CA
PRO
A
398
42.574
−16.415
0.279
1.00
10.32
A
C


ATOM
6319
CB
PRO
A
398
41.095
−16.282
0.665
1.00
10.50
A
C


ATOM
6322
CG
PRO
A
398
41.013
−16.848
2.032
1.00
10.24
A
C


ATOM
6325
CD
PRO
A
398
42.295
−16.448
2.683
1.00
10.64
A
C


ATOM
6328
C
PRO
A
398
43.024
−15.235
−0.571
1.00
9.73
A
C


ATOM
6329
O
PRO
A
398
43.301
−15.405
−1.755
1.00
9.10
A
O


ATOM
6330
N
LEU
A
399
43.113
−14.054
0.030
1.00
9.90
A
N


ATOM
6331
CA
LEU
A
399
43.532
−12.871
−0.712
1.00
10.55
A
C


ATOM
6333
CB
LEU
A
399
43.538
−11.626
0.179
1.00
10.41
A
C


ATOM
6336
CG
LEU
A
399
43.677
−10.296
−0.568
1.00
9.15
A
C


ATOM
6338
CD1
LEU
A
399
43.004
−9.192
0.209
1.00
10.37
A
C


ATOM
6342
CD2
LEU
A
399
45.134
−9.947
−0.838
1.00
8.74
A
C


ATOM
6346
C
LEU
A
399
44.911
−13.095
−1.322
1.00
11.44
A
C


ATOM
6347
O
LEU
A
399
45.102
−12.893
−2.520
1.00
12.07
A
O


ATOM
6349
N
GLN
A
400
45.861
−13.534
−0.500
1.00
11.78
A
N


ATOM
6350
CA
GLN
A
400
47.230
−13.779
−0.966
1.00
12.03
A
C


ATOM
6352
CB
GLN
A
400
48.106
−14.301
0.176
1.00
12.44
A
C


ATOM
6355
CG
GLN
A
400
48.616
−13.216
1.117
1.00
12.64
A
C


ATOM
6358
CD
GLN
A
400
49.595
−13.754
2.141
1.00
11.76
A
C


ATOM
6359
OE1
GLN
A
400
50.554
−14.442
1.799
1.00
11.16
A
O


ATOM
6360
NE2
GLN
A
400
49.353
−13.447
3.407
1.00
12.59
A
N


ATOM
6363
C
GLN
A
400
47.308
−14.742
−2.155
1.00
11.86
A
C


ATOM
6364
O
GLN
A
400
48.147
−14.574
−3.038
1.00
11.52
A
O


ATOM
6366
N
LEU
A
401
46.443
−15.750
−2.176
1.00
12.22
A
N


ATOM
6367
CA
LEU
A
401
46.442
−16.721
−3.269
1.00
12.76
A
C


ATOM
6369
CB
LEU
A
401
45.926
−18.087
−2.791
1.00
12.53
A
C


ATOM
6372
CG
LEU
A
401
46.818
−18.811
−1.772
1.00
11.90
A
C


ATOM
6374
CD1
LEU
A
401
46.158
−20.09
−1.294
1.00
13.20
A
C


ATOM
6378
CD2
LEU
A
401
48.195
−19.11
−2.346
1.00
9.64
A
C


ATOM
6382
C
LEU
A
401
45.649
−16.225
−4.485
1.00
13.27
A
C


ATOM
6383
O
LEU
A
401
45.910
−16.662
−5.609
1.00
13.80
A
O


ATOM
6385
N
VAL
A
402
44.693
−15.320
−4.272
1.00
13.43
A
N


ATOM
6386
CA
VAL
A
402
43.968
−14.700
−5.391
1.00
13.52
A
C


ATOM
6388
CB
VAL
A
402
42.791
−13.811
−4.915
1.00
13.58
A
C


ATOM
6390
CG1
VAL
A
402
41.759
−14.647
−4.186
1.00
14.22
A
C


ATOM
6394
CG2
VAL
A
402
42.146
−13.090
−6.093
1.00
11.75
A
C


ATOM
6398
C
VAL
A
402
44.924
−13.864
−6.244
1.00
13.38
A
C


ATOM
6399
O
VAL
A
402
44.798
−13.827
−7.463
1.00
13.04
A
O


ATOM
6401
N
PHE
A
403
45.880
−13.207
−5.594
1.00
13.34
A
N


ATOM
6402
CA
PHE
A
403
46.916
−12.455
−6.301
1.00
13.95
A
C


ATOM
6404
CB
PHE
A
403
47.544
−11.410
−5.376
1.00
14.44
A
C


ATOM
6407
CG
PHE
A
403
46.673
−10.206
−5.155
1.00
14.69
A
C


ATOM
6408
CD1
PHE
A
403
46.949
−9.004
−5.795
1.00
13.14
A
C


ATOM
6410
CE1
PHE
A
403
46.140
−7.903
−5.598
1.00
13.57
A
C


ATOM
6412
CZ
PHE
A
403
45.035
−7.999
−4.763
1.00
14.00
A
C


ATOM
6414
CE2
PHE
A
403
44.749
−9.191
−4.128
1.00
12.73
A
C


ATOM
6416
CD2
PHE
A
403
45.560
−10.285
−4.328
1.00
12.55
A
C


ATOM
6418
C
PHE
A
403
47.991
−13.378
−6.867
1.00
13.90
A
C


ATOM
6419
O
PHE
A
403
48.496
−13.154
−7.971
1.00
13.60
A
O


ATOM
6421
N
ALA
A
404
48.335
−14.411
−6.101
1.00
14.11
A
N


ATOM
6422
CA
ALA
A
404
49.301
−15.419
−6.533
1.00
14.01
A
C


ATOM
6424
CB
ALA
A
404
49.536
−16.439
−5.420
1.00
14.07
A
C


ATOM
6428
C
ALA
A
404
48.850
−16.123
−7.813
1.00
13.46
A
C


ATOM
6429
O
ALA
A
404
49.676
−16.483
−8.651
1.00
13.31
A
O


ATOM
6431
N
TYR
A
405
47.542
−16.315
−7.960
1.00
13.06
A
N


ATOM
6432
CA
TYR
A
405
46.990
−16.912
−9.172
1.00
13.33
A
C


ATOM
6434
CB
TYR
A
405
45.458
−16.967
−9.110
1.00
12.98
A
C


ATOM
6437
CG
TYR
A
405
44.842
−17.457
−10.398
1.00
11.28
A
C


ATOM
6438
CD1
TYR
A
405
44.849
−18.808
−10.721
1.00
11.80
A
C


ATOM
6440
CE1
TYR
A
405
44.297
−19.269
−11.914
1.00
11.52
A
C


ATOM
6442
CZ
TYR
A
405
43.741
−18.369
−12.801
1.00
10.95
A
C


ATOM
6443
OH
TYR
A
405
43.199
−18.819
−13.980
1.00
9.66
A
O


ATOM
6445
CE2
TYR
A
405
43.729
−17.016
−12.505
1.00
11.40
A
C


ATOM
6447
CD2
TYR
A
405
44.280
−16.568
−11.308
1.00
10.90
A
C


ATOM
6449
C
TYR
A
405
47.424
−16.133
−10.411
1.00
14.22
A
C


ATOM
6450
O
TYR
A
405
47.961
−16.709
−11.360
1.00
14.09
A
O


ATOM
6452
N
PHE
A
406
47.198
−14.820
−10.384
1.00
15.24
A
N


ATOM
6453
CA
PHE
A
406
47.442
−13.958
−11.546
1.00
15.22
A
C


ATOM
6455
CB
PHE
A
406
46.733
−12.613
−11.377
1.00
14.88
A
C


ATOM
6458
CG
PHE
A
406
45.237
−12.722
−11.317
1.00
13.53
A
C


ATOM
6459
CD1
PHE
A
406
44.504
−13.009
−12.458
1.00
13.38
A
C


ATOM
6461
CE1
PHE
A
406
43.126
−13.107
−12.408
1.00
12.53
A
C


ATOM
6463
CZ
PHE
A
406
42.465
−12.913
−11.210
1.00
12.19
A
C


ATOM
6465
CE2
PHE
A
406
43.186
−12.623
−10.068
1.00
11.97
A
C


ATOM
6467
CD2
PHE
A
406
44.563
−12.528
−10.126
1.00
11.83
A
C


ATOM
6469
C
PHE
A
406
48.922
−13.717
−11.831
1.00
15.89
A
C


ATOM
6470
O
PHE
A
406
49.267
−13.239
−12.912
1.00
16.18
A
O


ATOM
6472
N
ALA
A
407
49.789
−14.025
−10.868
1.00
16.30
A
N


ATOM
6473
CA
ALA
A
407
51.230
−13.919
−11.078
1.00
16.47
A
C


ATOM
6475
CB
ALA
A
407
51.945
−13.724
−9.764
1.00
16.54
A
C


ATOM
6479
C
ALA
A
407
51.764
−15.156
−11.785
1.00
17.01
A
C


ATOM
6480
O
ALA
A
407
52.403
−15.039
−12.828
1.00
17.63
A
O


ATOM
6482
N
VAL
A
408
51.479
−16.333
−11.227
1.00
17.52
A
N


ATOM
6483
CA
VAL
A
408
52.125
−17.582
−11.661
1.00
18.18
A
C


ATOM
6485
CB
VAL
A
408
52.196
−18.620
−10.509
1.00
18.02
A
C


ATOM
6487
CG1
VAL
A
408
52.962
−18.048
−9.323
1.00
17.51
A
C


ATOM
6491
CG2
VAL
A
408
50.808
−19.070
−10.091
1.00
17.56
A
C


ATOM
6495
C
VAL
A
408
51.510
−18.259
−12.896
1.00
19.13
A
C


ATOM
6496
O
VAL
A
408
52.226
−18.899
−13.665
1.00
19.26
A
O


ATOM
6498
N
VAL
A
409
50.201
−18.127
−13.088
1.00
20.36
A
N


ATOM
6499
CA
VAL
A
409
49.523
−18.799
−14.203
1.00
21.49
A
C


ATOM
6501
CB
VAL
A
409
48.010
−18.951
−13.934
1.00
21.39
A
C


ATOM
6503
CG1
VAL
A
409
47.353
−19.765
−15.036
1.00
22.15
A
C


ATOM
6507
CG2
VAL
A
409
47.771
−19.611
−12.584
1.00
22.07
A
C


ATOM
6511
C
VAL
A
409
49.722
−18.038
−15.521
1.00
22.53
A
C


ATOM
6512
O
VAL
A
409
49.629
−16.808
−15.547
1.00
23.27
A
O


ATOM
6514
N
GLN
A
410
49.994
−18.768
−16.607
1.00
23.04
A
N


ATOM
6515
CA
GLN
A
410
50.117
−18.159
−17.940
1.00
23.44
A
C


ATOM
6517
CB
GLN
A
410
50.609
−19.176
−18.988
1.00
23.94
A
C


ATOM
6520
CG
GLN
A
410
52.109
−19.114
−19.307
1.00
25.78
A
C


ATOM
6523
CD
GLN
A
410
52.465
−19.825
−20.619
1.00
27.06
A
C


ATOM
6524
OE1
GLN
A
410
52.543
−21.055
−20.676
1.00
27.24
A
O


ATOM
6525
NE2
GLN
A
410
52.688
−19.047
−21.675
1.00
25.76
A
N


ATOM
6528
C
GLN
A
410
48.782
−17.546
−18.378
1.00
23.54
A
C


ATOM
6529
O
GLN
A
410
48.589
−16.335
−18.271
1.00
23.64
A
O


ATOM
6531
N
ASN
A
411
47.864
−18.385
−18.853
1.00
23.79
A
N


ATOM
6532
CA
ASN
A
411
46.560
−17.921
−19.321
1.00
23.91
A
C


ATOM
6534
CB
ASN
A
411
46.095
−18.734
−20.535
1.00
24.06
A
C


ATOM
6537
CG
ASN
A
411
46.913
−18.446
−21.784
1.00
24.54
A
C


ATOM
6538
OD1
ASN
A
411
46.413
−17.859
−22.745
1.00
23.89
A
O


ATOM
6539
ND2
ASN
A
411
48.178
−18.858
−21.775
1.00
24.71
A
N


ATOM
6542
C
ASN
A
411
45.514
−18.009
−18.219
1.00
23.88
A
C


ATOM
6543
O
ASN
A
411
45.574
−18.888
−17.361
1.00
23.42
A
O


ATOM
6545
N
ILE
A
412
44.547
−17.098
−18.267
1.00
24.33
A
N


ATOM
6546
CA
ILE
A
412
43.466
−17.042
−17.285
1.00
24.54
A
C


ATOM
6548
CB
ILE
A
412
43.018
−15.583
−17.036
1.00
24.66
A
C


ATOM
6550
CG1
ILE
A
412
44.224
−14.686
−16.727
1.00
24.61
A
C


ATOM
6553
CD1
ILE
A
412
45.133
−15.218
−15.646
1.00
24.33
A
C


ATOM
6557
CG2
ILE
A
412
41.997
−15.516
−15.910
1.00
25.28
A
C


ATOM
6561
C
ILE
A
412
42.267
−17.841
−17.788
1.00
24.52
A
C


ATOM
6562
O
ILE
A
412
41.795
−17.612
−18.901
1.00
24.75
A
O


ATOM
6564
N
LYS
A
413
41.776
−18.771
−16.973
1.00
24.56
A
N


ATOM
6565
CA
LYS
A
413
40.589
−19.552
−17.323
1.00
24.82
A
C


ATOM
6567
CB
LYS
A
413
40.819
−21.041
−17.055
1.00
25.06
A
C


ATOM
6570
CG
LYS
A
413
42.016
−21.623
−17.795
1.00
25.64
A
C


ATOM
6573
CD
LYS
A
413
41.849
−23.112
−18.064
1.00
28.37
A
C


ATOM
6576
CE
LYS
A
413
42.855
−23.606
−19.100
1.00
30.53
A
C


ATOM
6579
NZ
LYS
A
413
42.618
−25.028
−19.493
1.00
30.83
A
N


ATOM
6583
C
LYS
A
413
39.389
−19.053
−16.530
1.00
24.68
A
C


ATOM
6584
O
LYS
A
413
39.521
−18.714
−15.352
1.00
23.95
A
O


ATOM
6586
N
LYS
A
414
38.225
−19.005
−17.176
1.00
25.21
A
N


ATOM
6587
CA
LYS
A
414
37.006
−18.530
−16.517
1.00
25.78
A
C


ATOM
6589
CB
LYS
A
414
35.845
−18.387
−17.509
1.00
25.92
A
C


ATOM
6592
CG
LYS
A
414
34.681
−17.556
−16.956
1.00
27.75
A
C


ATOM
6595
CD
LYS
A
414
33.572
−17.312
−17.982
1.00
28.34
A
C


ATOM
6598
CE
LYS
A
414
32.817
−18.588
−18.334
1.00
28.85
A
C


ATOM
6601
NZ
LYS
A
414
32.295
−19.301
−17.133
1.00
28.73
A
N


ATOM
6605
C
LYS
A
414
36.612
−19.462
−15.371
1.00
25.94
A
C


ATOM
6606
O
LYS
A
414
36.215
−18.997
−14.301
1.00
26.04
A
O


ATOM
6608
N
GLU
A
415
36.734
−20.771
−15.598
1.00
25.93
A
N


ATOM
6609
CA
GLU
A
415
36.443
−21.772
−14.567
1.00
25.59
A
C


ATOM
6611
CB
GLU
A
415
36.571
−23.194
−15.129
1.00
25.91
A
C


ATOM
6614
CG
GLU
A
415
35.980
−24.278
−14.212
1.00
27.72
A
C


ATOM
6617
CD
GLU
A
415
36.785
−25.576
−14.192
1.00
29.56
A
C


ATOM
6618
OE1
GLU
A
415
38.035
−25.519
−14.216
1.00
30.42
A
O


ATOM
6619
OE2
GLU
A
415
36.160
−26.658
−14.127
1.00
30.95
A
O


ATOM
6620
C
GLU
A
415
37.375
−21.614
−13.367
1.00
24.71
A
C


ATOM
6621
O
GLU
A
415
36.925
−21.641
−12.221
1.00
24.35
A
O


ATOM
6623
N
GLU
A
416
38.668
−21.455
−13.635
1.00
24.19
A
N


ATOM
6624
CA
GLU
A
416
39.653
−21.259
−12.574
1.00
24.24
A
C


ATOM
6626
CB
GLU
A
416
41.062
−21.074
−13.151
1.00
24.41
A
C


ATOM
6629
CG
GLU
A
416
41.712
−22.376
−13.612
1.00
25.81
A
C


ATOM
6632
CD
GLU
A
416
43.177
−22.214
−13.985
1.00
26.72
A
C


ATOM
6633
OE1
GLU
A
416
43.547
−21.142
−14.507
1.00
27.38
A
O


ATOM
6634
OE2
GLU
A
416
43.958
−23.166
−13.764
1.00
26.58
A
O


ATOM
6635
C
GLU
A
416
39.291
−20.077
−11.673
1.00
23.98
A
C


ATOM
6636
O
GLU
A
416
39.215
−20.232
−10.454
1.00
23.87
A
O


ATOM
6638
N
ILE
A
417
39.052
−18.910
−12.269
1.00
23.83
A
N


ATOM
6639
CA
ILE
A
417
38.704
−17.719
−11.484
1.00
23.96
A
C


ATOM
6641
CB
ILE
A
417
38.800
−16.395
−12.301
1.00
24.26
A
C


ATOM
6643
CG1
ILE
A
417
37.708
−16.310
−13.373
1.00
24.99
A
C


ATOM
6646
CD1
ILE
A
417
37.647
−14.966
−14.065
1.00
24.44
A
C


ATOM
6650
CG2
ILE
A
417
40.185
−16.249
−12.925
1.00
23.85
A
C


ATOM
6654
C
ILE
A
417
37.316
−17.828
−10.848
1.00
23.84
A
C


ATOM
6655
O
ILE
A
417
37.052
−17.190
−9.832
1.00
23.74
A
O


ATOM
6657
N
GLU
A
418
36.438
−18.631
−11.448
1.00
23.87
A
N


ATOM
6658
CA
GLU
A
418
35.107
−18.886
−10.882
1.00
24.02
A
C


ATOM
6660
CB
GLU
A
418
34.281
−19.798
−11.802
1.00
24.29
A
C


ATOM
6663
CG
GLU
A
418
32.821
−19.382
−11.980
1.00
25.56
A
C


ATOM
6666
CD
GLU
A
418
32.536
−18.833
−13.367
1.00
27.78
A
C


ATOM
6667
OE1
GLU
A
418
32.836
−19.536
−14.358
1.00
29.63
A
O


ATOM
6668
OE2
GLU
A
418
32.003
−17.707
−13.469
1.00
28.94
A
O


ATOM
6669
C
GLU
A
418
35.227
−19.551
−9.510
1.00
23.54
A
C


ATOM
6670
O
GLU
A
418
34.483
−19.225
−8.585
1.00
23.37
A
O


ATOM
6672
N
ASN
A
419
36.161
−20.494
−9.399
1.00
23.03
A
N


ATOM
6673
CA
ASN
A
419
36.414
−21.200
−8.144
1.00
22.72
A
C


ATOM
6675
CB
ASN
A
419
37.219
−22.481
−8.399
1.00
22.49
A
C


ATOM
6678
CG
ASN
A
419
36.353
−23.621
−8.901
1.00
21.26
A
C


ATOM
6679
OD1
ASN
A
419
35.999
−24.523
−8.143
1.00
20.38
A
O


ATOM
6680
ND2
ASN
A
419
35.994
−23.577
−10.176
1.00
18.71
A
N


ATOM
6683
C
ASN
A
419
37.110
−20.332
−7.094
1.00
22.76
A
C


ATOM
6684
O
ASN
A
419
36.831
−20.460
−5.901
1.00
22.68
A
O


ATOM
6686
N
LEU
A
420
38.007
−19.450
−7.535
1.00
23.02
A
N


ATOM
6687
CA
LEU
A
420
38.646
−18.485
−6.630
1.00
23.24
A
C


ATOM
6689
CB
LEU
A
420
39.740
−17.689
−7.352
1.00
23.12
A
C


ATOM
6692
CG
LEU
A
420
40.950
−18.465
−7.878
1.00
22.58
A
C


ATOM
6694
CD1
LEU
A
420
41.884
−17.542
−8.649
1.00
23.76
A
C


ATOM
6698
CD2
LEU
A
420
41.694
−19.150
−6.747
1.00
21.73
A
C


ATOM
6702
C
LEU
A
420
37.616
−17.519
−6.037
1.00
23.34
A
C


ATOM
6703
O
LEU
A
420
37.698
−17.159
−4.862
1.00
23.29
A
O


ATOM
6705
N
GLN
A
421
36.649
−17.113
−6.859
1.00
23.39
A
N


ATOM
6706
CA
GLN
A
421
35.555
−16.240
−6.426
1.00
23.61
A
C


ATOM
6708
CB
GLN
A
421
34.664
−15.883
−7.619
1.00
23.81
A
C


ATOM
6711
CG
GLN
A
421
35.317
−14.977
−8.655
1.00
25.57
A
C


ATOM
6714
CD
GLN
A
421
35.021
−13.508
−8.426
1.00
27.53
A
C


ATOM
6715
OE1
GLN
A
421
34.355
−12.867
−9.241
1.00
27.80
A
O


ATOM
6716
NE2
GLN
A
421
35.507
−12.967
−7.310
1.00
28.75
A
N


ATOM
6719
C
GLN
A
421
34.687
−16.871
−5.336
1.00
23.75
A
C


ATOM
6720
O
GLN
A
421
34.012
−16.160
−4.594
1.00
23.75
A
O


ATOM
6722
N
LYS
A
422
34.699
−18.202
−5.254
1.00
24.07
A
N


ATOM
6723
CA
LYS
A
422
33.875
−18.944
−4.301
1.00
24.27
A
C


ATOM
6725
CB
LYS
A
422
33.053
−19.995
−5.060
1.00
24.49
A
C


ATOM
6728
CG
LYS
A
422
32.059
−19.388
−6.053
1.00
26.08
A
C


ATOM
6731
CD
LYS
A
422
31.640
−20.375
−7.140
1.00
28.24
A
C


ATOM
6734
CE
LYS
A
422
30.776
−19.693
−8.205
1.00
28.90
A
C


ATOM
6737
NZ
LYS
A
422
30.279
−20.642
−9.246
1.00
28.82
A
N


ATOM
6741
C
LYS
A
422
34.716
−19.603
−3.196
1.00
23.98
A
C


ATOM
6742
O
LYS
A
422
34.248
−20.524
−2.519
1.00
23.87
A
O


ATOM
6744
N
TYR
A
423
35.942
−19.107
−3.005
1.00
23.57
A
N


ATOM
6745
CA
TYR
A
423
36.902
−19.675
−2.046
1.00
23.15
A
C


ATOM
6747
CB
TYR
A
423
36.697
−19.077
−0.643
1.00
22.87
A
C


ATOM
6750
CG
TYR
A
423
36.761
−17.559
−0.637
1.00
23.55
A
C


ATOM
6751
CD1
TYR
A
423
37.857
−16.888
−1.182
1.00
24.97
A
C


ATOM
6753
CE1
TYR
A
423
37.919
−15.497
−1.197
1.00
24.81
A
C


ATOM
6755
CZ
TYR
A
423
36.880
−14.761
−0.660
1.00
24.32
A
C


ATOM
6756
OH
TYR
A
423
36.945
−13.388
−0.673
1.00
23.63
A
O


ATOM
6758
CE2
TYR
A
423
35.782
−15.400
−0.110
1.00
23.79
A
C


ATOM
6760
CD2
TYR
A
423
35.726
−16.794
−0.102
1.00
24.22
A
C


ATOM
6762
C
TYR
A
423
36.847
−21.206
−2.046
1.00
22.87
A
C


ATOM
6763
O
TYR
A
423
36.540
−21.849
−1.038
1.00
23.25
A
O


ATOM
6765
N
HIS
A
424
37.144
−21.765
−3.214
1.00
22.22
A
N


ATOM
6766
CA
HIS
A
424
37.125
−23.205
−3.449
1.00
21.90
A
C


ATOM
6768
CB
HIS
A
424
37.276
−23.465
−4.956
1.00
22.14
A
C


ATOM
6771
CG
HIS
A
424
37.467
−24.904
−5.320
1.00
23.25
A
C


ATOM
6772
ND1
HIS
A
424
38.681
−25.408
−5.734
1.00
23.32
A
N


ATOM
6774
CE1
HIS
A
424
38.555
−26.698
−5.989
1.00
23.99
A
C


ATOM
6776
NE2
HIS
A
424
37.303
−27.049
−5.758
1.00
24.51
A
N


ATOM
6778
CD2
HIS
A
424
36.600
−25.944
−5.341
1.00
24.99
A
C


ATOM
6780
C
HIS
A
424
38.232
−23.894
−2.652
1.00
21.23
A
C


ATOM
6781
O
HIS
A
424
39.226
−23.266
−2.293
1.00
21.22
A
O


ATOM
6783
N
ASP
A
425
38.042
−25.184
−2.383
1.00
20.88
A
N


ATOM
6784
CA
ASP
A
425
38.963
−25.991
−1.561
1.00
20.94
A
C


ATOM
6786
CB
ASP
A
425
38.655
−27.491
−1.731
1.00
21.19
A
C


ATOM
6789
CG
ASP
A
425
37.337
−27.908
−1.083
1.00
22.84
A
C


ATOM
6790
OD1
ASP
A
425
36.714
−27.086
−0.374
1.00
27.02
A
O


ATOM
6791
OD2
ASP
A
425
36.923
−29.070
−1.284
1.00
23.18
A
O


ATOM
6792
C
ASP
A
425
40.467
−25.759
−1.800
1.00
20.30
A
C


ATOM
6793
O
ASP
A
425
41.253
−25.806
−0.851
1.00
20.33
A
O


ATOM
6795
N
THR
A
426
40.870
−25.519
−3.046
1.00
19.20
A
N


ATOM
6796
CA
THR
A
426
42.295
−25.401
−3.366
1.00
18.17
A
C


ATOM
6798
CB
THR
A
426
42.546
−25.212
−4.878
1.00
17.95
A
C


ATOM
6800
OG1
THR
A
426
41.842
−26.219
−5.612
1.00
17.41
A
O


ATOM
6802
CG2
THR
A
426
44.033
−25.315
−5.196
1.00
15.99
A
C


ATOM
6806
C
THR
A
426
42.960
−24.263
−2.597
1.00
17.94
A
C


ATOM
6807
O
THR
A
426
44.085
−24.424
−2.127
1.00
18.23
A
O


ATOM
6809
N
ILE
A
427
42.270
−23.127
−2.471
1.00
17.76
A
N


ATOM
6810
CA
ILE
A
427
42.795
−21.979
−1.711
1.00
17.88
A
C


ATOM
6812
CB
ILE
A
427
42.699
−20.642
−2.499
1.00
17.38
A
C


ATOM
6814
CG1
ILE
A
427
41.246
−20.209
−2.701
1.00
16.70
A
C


ATOM
6817
CD1
ILE
A
427
41.119
−18.858
−3.365
1.00
16.78
A
C


ATOM
6821
CG2
ILE
A
427
43.415
−20.755
−3.836
1.00
16.09
A
C


ATOM
6825
C
ILE
A
427
42.137
−21.803
−0.339
1.00
18.62
A
C


ATOM
6826
O
ILE
A
427
42.602
−20.996
0.471
1.00
19.27
A
O


ATOM
6828
N
SER
A
428
41.065
−22.550
−0.082
1.00
18.85
A
N


ATOM
6829
CA
SER
A
428
40.426
−22.561
1.233
1.00
19.03
A
C


ATOM
6831
CB
SER
A
428
39.035
−23.200
1.145
1.00
18.90
A
C


ATOM
6834
OG
SER
A
428
38.499
−23.466
2.429
1.00
19.43
A
O


ATOM
6836
C
SER
A
428
41.291
−23.317
2.241
1.00
19.40
A
C


ATOM
6837
O
SER
A
428
41.671
−22.772
3.274
1.00
19.21
A
O


ATOM
6839
N
ARG
A
429
41.614
−24.566
1.914
1.00
20.31
A
N


ATOM
6840
CA
ARG
A
429
42.331
−25.465
2.833
1.00
20.92
A
C


ATOM
6842
CB
ARG
A
429
42.587
−26.839
2.185
1.00
21.25
A
C


ATOM
6845
CG
ARG
A
429
41.326
−27.586
1.733
1.00
23.47
A
C


ATOM
6848
CD
ARG
A
429
40.833
−28.594
2.762
1.00
26.54
A
C


ATOM
6851
NE
ARG
A
429
39.381
−28.778
2.710
1.00
28.25
A
N


ATOM
6853
CZ
ARG
A
429
38.719
−29.394
1.730
1.00
29.99
A
C


ATOM
6854
NH1
ARG
A
429
39.359
−29.903
0.676
1.00
29.63
A
N


ATOM
6857
NH2
ARG
A
429
37.396
−29.497
1.801
1.00
30.83
A
N


ATOM
6860
C
ARG
A
429
43.649
−24.871
3.347
1.00
20.52
A
C


ATOM
6861
O
ARG
A
429
43.869
−24.835
4.555
1.00
20.89
A
O


ATOM
6863
N
PRO
A
430
44.524
−24.388
2.442
1.00
19.92
A
N


ATOM
6864
CA
PRO
A
430
45.782
−23.822
2.933
1.00
19.69
A
C


ATOM
6866
CB
PRO
A
430
46.451
−23.278
1.664
1.00
19.80
A
C


ATOM
6869
CG
PRO
A
430
45.801
−23.986
0.541
1.00
19.77
A
C


ATOM
6872
CD
PRO
A
430
44.400
−24.245
0.982
1.00
20.08
A
C


ATOM
6875
C
PRO
A
430
45.558
−22.695
3.934
1.00
19.44
A
C


ATOM
6876
O
PRO
A
430
46.314
−22.573
4.898
1.00
19.69
A
O


ATOM
6877
N
SER
A
431
44.520
−21.891
3.701
1.00
19.05
A
N


ATOM
6878
CA
SER
A
431
44.171
−20.780
4.591
1.00
18.38
A
C


ATOM
6880
CB
SER
A
431
43.173
−19.843
3.910
1.00
18.34
A
C


ATOM
6883
OG
SER
A
431
43.653
−19.431
2.639
1.00
18.28
A
O


ATOM
6885
C
SER
A
431
43.610
−21.273
5.925
1.00
17.67
A
C


ATOM
6886
O
SER
A
431
43.797
−20.621
6.954
1.00
16.78
A
O


ATOM
6888
N
HIS
A
432
42.922
−22.417
5.896
1.00
17.38
A
N


ATOM
6889
CA
HIS
A
432
42.501
−23.105
7.121
1.00
17.22
A
C


ATOM
6891
CB
HIS
A
432
41.774
−24.426
6.803
1.00
17.35
A
C


ATOM
6894
CG
HIS
A
432
40.354
−24.255
6.353
1.00
16.88
A
C


ATOM
6895
ND1
HIS
A
432
39.389
−25.215
6.569
1.00
16.42
A
N


ATOM
6897
CE1
HIS
A
432
38.237
−24.799
6.074
1.00
16.45
A
C


ATOM
6899
NE2
HIS
A
432
38.418
−23.601
5.548
1.00
14.80
A
N


ATOM
6901
CD2
HIS
A
432
39.733
−23.236
5.712
1.00
16.06
A
C


ATOM
6903
C
HIS
A
432
43.723
−23.383
8.002
1.00
16.93
A
C


ATOM
6904
O
HIS
A
432
43.687
−23.163
9.215
1.00
16.68
A
O


ATOM
6906
N
ILE
A
433
44.800
−23.862
7.378
1.00
16.43
A
N


ATOM
6907
CA
ILE
A
433
46.064
−24.108
8.078
1.00
16.05
A
C


ATOM
6909
CB
ILE
A
433
47.080
−24.877
7.189
1.00
16.29
A
C


ATOM
6911
CG1
ILE
A
433
46.752
−26.374
7.152
1.00
16.71
A
C


ATOM
6914
CD1
ILE
A
433
45.604
−26.727
6.261
1.00
15.49
A
C


ATOM
6918
CG2
ILE
A
433
48.505
−24.683
7.704
1.00
17.15
A
C


ATOM
6922
C
ILE
A
433
46.710
−22.804
8.553
1.00
15.22
A
C


ATOM
6923
O
ILE
A
433
47.267
−22.751
9.648
1.00
15.08
A
O


ATOM
6925
N
PHE
A
434
46.631
−21.765
7.725
1.00
14.47
A
N


ATOM
6926
CA
PHE
A
434
47.211
−20.455
8.034
1.00
14.05
A
C


ATOM
6928
CB
PHE
A
434
47.038
−19.527
6.814
1.00
13.92
A
C


ATOM
6931
CG
PHE
A
434
47.583
−18.117
6.985
1.00
13.80
A
C


ATOM
6932
CD1
PHE
A
434
48.512
−17.785
7.967
1.00
14.68
A
C


ATOM
6934
CE1
PHE
A
434
48.987
−16.482
8.081
1.00
13.77
A
C


ATOM
6936
CZ
PHE
A
434
48.558
−15.508
7.200
1.00
12.50
A
C


ATOM
6938
CE2
PHE
A
434
47.654
−15.829
6.213
1.00
11.41
A
C


ATOM
6940
CD2
PHE
A
434
47.177
−17.122
6.104
1.00
13.10
A
C


ATOM
6942
C
PHE
A
434
46.599
−19.864
9.311
1.00
13.97
A
C


ATOM
6943
O
PHE
A
434
47.325
−19.429
10.208
1.00
13.34
A
O


ATOM
6945
N
ARG
A
435
45.273
−19.878
9.407
1.00
14.22
A
N


ATOM
6946
CA
ARG
A
435
44.594
−19.371
10.603
1.00
14.37
A
C


ATOM
6948
CB
ARG
A
435
43.086
−19.241
10.359
1.00
14.35
A
C


ATOM
6951
CG
ARG
A
435
42.252
−18.907
11.593
1.00
15.10
A
C


ATOM
6954
CD
ARG
A
435
42.754
−17.675
12.337
1.00
16.05
A
C


ATOM
6957
NE
ARG
A
435
42.700
−16.464
11.524
1.00
17.00
A
N


ATOM
6959
CZ
ARG
A
435
43.235
−15.293
11.870
1.00
18.01
A
C


ATOM
6960
NH1
ARG
A
435
43.888
−15.153
13.020
1.00
18.43
A
N


ATOM
6963
NH2
ARG
A
435
43.121
−14.253
11.054
1.00
18.41
A
N


ATOM
6966
C
ARG
A
435
44.864
−20.264
11.813
1.00
14.63
A
C


ATOM
6967
O
ARG
A
435
45.259
−19.774
12.870
1.00
14.88
A
O


ATOM
6969
N
LEU
A
436
44.650
−21.569
11.651
1.00
14.88
A
N


ATOM
6970
CA
LEU
A
436
44.874
−22.531
12.735
1.00
14.69
A
C


ATOM
6972
CB
LEU
A
436
44.567
−23.964
12.274
1.00
14.43
A
C


ATOM
6975
CG
LEU
A
436
43.095
−24.373
12.141
1.00
12.91
A
C


ATOM
6977
CD1
LEU
A
436
42.975
−25.815
11.667
1.00
9.69
A
C


ATOM
6981
CD2
LEU
A
436
42.353
−24.194
13.454
1.00
11.60
A
C


ATOM
6985
C
LEU
A
436
46.300
−22.450
13.302
1.00
15.09
A
C


ATOM
6986
O
LEU
A
436
46.480
−22.448
14.519
1.00
15.32
A
O


ATOM
6988
N
CYS
A
437
47.303
−22.375
12.429
1.00
15.32
A
N


ATOM
6989
CA
CYS
A
437
48.692
−22.223
12.877
1.00
15.91
A
C


ATOM
6991
CB
CYS
A
437
49.663
−22.121
11.693
1.00
16.11
A
C


ATOM
6994
SG
CYS
A
437
50.204
−23.702
11.009
1.00
15.22
A
S


ATOM
6996
C
CYS
A
437
48.848
−20.989
13.763
1.00
16.70
A
C


ATOM
6997
O
CYS
A
437
49.285
−21.100
14.910
1.00
17.68
A
O


ATOM
6999
N
ASN
A
438
48.485
−19.825
13.224
1.00
16.73
A
N


ATOM
7000
CA
ASN
A
438
48.591
−18.548
13.946
1.00
16.68
A
C


ATOM
7002
CB
ASN
A
438
47.902
−17.428
13.148
1.00
16.72
A
C


ATOM
7005
CG
ASN
A
438
48.141
−16.036
13.733
1.00
16.65
A
C


ATOM
7006
OD1
ASN
A
438
48.240
−15.855
14.947
1.00
18.65
A
O


ATOM
7007
ND2
ASN
A
438
48.214
−15.042
12.858
1.00
16.47
A
N


ATOM
7010
C
ASN
A
438
47.993
−18.634
15.349
1.00
16.53
A
C


ATOM
7011
O
ASN
A
438
48.666
−18.340
16.343
1.00
16.47
A
O


ATOM
7013
N
ASP
A
439
46.735
−19.055
15.417
1.00
16.27
A
N


ATOM
7014
CA
ASP
A
439
45.992
−19.076
16.672
1.00
16.30
A
C


ATOM
7016
CB
ASP
A
439
44.503
−19.296
16.400
1.00
16.10
A
C


ATOM
7019
CG
ASP
A
439
43.872
−18.134
15.650
1.00
15.85
A
C


ATOM
7020
OD1
ASP
A
439
44.623
−17.292
15.112
1.00
14.52
A
O


ATOM
7021
OD2
ASP
A
439
42.626
−18.059
15.598
1.00
16.49
A
O


ATOM
7022
C
ASP
A
439
46.527
−20.115
17.660
1.00
16.83
A
C


ATOM
7023
O
ASP
A
439
46.451
−19.911
18.874
1.00
17.09
A
O


ATOM
7025
N
LEU
A
440
47.067
−21.219
17.145
1.00
17.06
A
N


ATOM
7026
CA
LEU
A
440
47.742
−22.215
17.987
1.00
17.22
A
C


ATOM
7028
CB
LEU
A
440
48.155
−23.442
17.166
1.00
17.05
A
C


ATOM
7031
CG
LEU
A
440
47.100
−24.537
17.019
1.00
15.68
A
C


ATOM
7033
CD1
LEU
A
440
47.460
−25.487
15.894
1.00
15.98
A
C


ATOM
7037
CD2
LEU
A
440
46.955
−25.288
18.321
1.00
15.39
A
C


ATOM
7041
C
LEU
A
440
48.972
−21.625
18.680
1.00
18.01
A
C


ATOM
7042
O
LEU
A
440
49.261
−21.965
19.830
1.00
17.74
A
O


ATOM
7044
N
ALA
A
441
49.685
−20.747
17.972
1.00
18.91
A
N


ATOM
7045
CA
ALA
A
441
50.883
−20.083
18.502
1.00
19.53
A
C


ATOM
7047
CB
ALA
A
441
51.622
−19.360
17.384
1.00
19.65
A
C


ATOM
7051
C
ALA
A
441
50.542
−19.101
19.616
1.00
19.96
A
C


ATOM
7052
O
ALA
A
441
51.224
−19.050
20.639
1.00
19.83
A
O


ATOM
7054
N
SER
A
442
49.480
−18.328
19.407
1.00
20.77
A
N


ATOM
7055
CA
SER
A
442
49.015
−17.350
20.387
1.00
21.70
A
C


ATOM
7057
CB
SER
A
442
48.473
−16.122
19.653
1.00
22.02
A
C


ATOM
7060
OG
SER
A
442
47.282
−16.440
18.950
1.00
22.89
A
O


ATOM
7062
C
SER
A
442
47.926
−17.911
21.312
1.00
22.14
A
C


ATOM
7063
O
SER
A
442
47.178
−17.149
21.924
1.00
22.10
A
O


ATOM
7065
N
ALA
A
443
47.845
−19.236
21.422
1.00
22.95
A
N


ATOM
7066
CA
ALA
A
443
46.762
−19.886
22.161
1.00
23.60
A
C


ATOM
7068
CB
ALA
A
443
46.779
−21.396
21.915
1.00
23.77
A
C


ATOM
7072
C
ALA
A
443
46.816
−19.592
23.660
1.00
24.06
A
C


ATOM
7073
O
ALA
A
443
45.974
−18.857
24.177
1.00
24.06
A
O


ATOM
7075
N
SER
A
444
47.813
−20.151
24.344
1.00
24.55
A
N


ATOM
7076
CA
SER
A
444
47.912
−20.054
25.806
1.00
24.88
A
C


ATOM
7078
CB
SER
A
444
49.039
−20.954
26.324
1.00
24.85
A
C


ATOM
7081
OG
SER
A
444
50.274
−20.624
25.714
1.00
25.18
A
O


ATOM
7083
C
SER
A
444
48.119
−18.625
26.320
1.00
25.16
A
C


ATOM
7084
O
SER
A
444
47.749
−18.315
27.456
1.00
25.37
A
O


ATOM
7086
N
ALA
A
445
48.709
−17.764
25.490
1.00
25.22
A
N


ATOM
7087
CA
ALA
A
445
48.924
−16.363
25.854
1.00
25.09
A
C


ATOM
7089
CB
ALA
A
445
49.820
−15.675
24.832
1.00
25.06
A
C


ATOM
7093
C
ALA
A
445
47.598
−15.622
25.971
1.00
25.09
A
C


ATOM
7094
O
ALA
A
445
47.333
−14.971
26.980
1.00
25.23
A
O


ATOM
7096
N
GLU
A
446
46.766
−15.738
24.939
1.00
25.16
A
N


ATOM
7097
CA
GLU
A
446
45.496
−15.009
24.873
1.00
25.34
A
C


ATOM
7099
CB
GLU
A
446
44.976
−14.984
23.430
1.00
25.42
A
C


ATOM
7102
CG
GLU
A
446
45.884
−14.210
22.473
1.00
26.40
A
C


ATOM
7105
CD
GLU
A
446
45.477
−14.336
21.012
1.00
27.93
A
C


ATOM
7106
OE1
GLU
A
446
44.450
−14.988
20.718
1.00
28.81
A
O


ATOM
7107
OE2
GLU
A
446
46.191
−13.776
20.153
1.00
27.41
A
O


ATOM
7108
C
GLU
A
446
44.421
−15.561
25.819
1.00
25.11
A
C


ATOM
7109
O
GLU
A
446
43.555
−14.812
26.273
1.00
24.91
A
O


ATOM
7111
N
ILE
A
447
44.482
−16.859
26.115
1.00
25.06
A
N


ATOM
7112
CA
ILE
A
447
43.524
−17.497
27.026
1.00
25.06
A
C


ATOM
7114
CB
ILE
A
447
43.578
−19.041
26.936
1.00
25.18
A
C


ATOM
7116
CG1
ILE
A
447
43.192
−19.522
25.535
1.00
25.37
A
C


ATOM
7119
CD1
ILE
A
447
43.705
−20.915
25.217
1.00
24.89
A
C


ATOM
7123
CG2
ILE
A
447
42.642
−19.672
27.963
1.00
24.79
A
C


ATOM
7127
C
ILE
A
447
43.793
−17.081
28.473
1.00
25.00
A
C


ATOM
7128
O
ILE
A
447
42.862
−16.762
29.216
1.00
25.06
A
O


ATOM
7130
N
ALA
A
448
45.066
−17.095
28.864
1.00
24.78
A
N


ATOM
7131
CA
ALA
A
448
45.479
−16.656
30.198
1.00
24.75
A
C


ATOM
7133
CB
ALA
A
448
46.968
−16.911
30.399
1.00
24.58
A
C


ATOM
7137
C
ALA
A
448
45.156
−15.177
30.439
1.00
24.85
A
C


ATOM
7138
O
ALA
A
448
44.840
−14.782
31.562
1.00
24.72
A
O


ATOM
7140
N
ARG
A
449
45.235
−14.370
29.381
1.00
25.19
A
N


ATOM
7141
CA
ARG
A
449
44.895
−12.944
29.453
1.00
25.36
A
C


ATOM
7143
CB
ARG
A
449
45.514
−12.181
28.272
1.00
25.38
A
C


ATOM
7146
CG
ARG
A
449
47.002
−11.884
28.451
1.00
25.01
A
C


ATOM
7149
CD
ARG
A
449
47.559
−10.951
27.375
1.00
23.90
A
C


ATOM
7152
NE
ARG
A
449
48.127
−11.685
26.242
1.00
22.76
A
N


ATOM
7154
CZ
ARG
A
449
47.765
−11.558
24.963
1.00
23.10
A
C


ATOM
7155
NH1
ARG
A
449
46.817
−10.705
24.588
1.00
22.37
A
N


ATOM
7158
NH2
ARG
A
449
48.374
−12.295
24.037
1.00
24.00
A
N


ATOM
7161
C
ARG
A
449
43.382
−12.686
29.517
1.00
25.70
A
C


ATOM
7162
O
ARG
A
449
42.958
−11.579
29.853
1.00
25.66
A
O


ATOM
7164
N
GLY
A
450
42.579
−13.699
29.190
1.00
26.09
A
N


ATOM
7165
CA
GLY
A
450
41.121
−13.619
29.310
1.00
26.27
A
C


ATOM
7168
C
GLY
A
450
40.432
−13.118
28.054
1.00
26.55
A
C


ATOM
7169
O
GLY
A
450
39.447
−12.383
28.132
1.00
26.90
A
O


ATOM
7171
N
GLU
A
451
40.949
−13.523
26.895
1.00
26.64
A
N


ATOM
7172
CA
GLU
A
451
40.382
−13.141
25.602
1.00
26.67
A
C


ATOM
7174
CB
GLU
A
451
41.475
−12.562
24.701
1.00
27.07
A
C


ATOM
7177
CG
GLU
A
451
42.137
−11.307
25.255
1.00
27.64
A
C


ATOM
7180
CD
GLU
A
451
43.464
−11.004
24.583
1.00
29.26
A
C


ATOM
7181
OE1
GLU
A
451
43.516
−10.980
23.333
1.00
28.51
A
O


ATOM
7182
OE2
GLU
A
451
44.455
−10.789
25.312
1.00
30.56
A
O


ATOM
7183
C
GLU
A
451
39.731
−14.348
24.925
1.00
26.15
A
C


ATOM
7184
O
GLU
A
451
39.901
−15.485
25.369
1.00
26.18
A
O


ATOM
7186
N
THR
A
452
38.986
−14.089
23.853
1.00
25.51
A
N


ATOM
7187
CA
THR
A
452
38.273
−15.142
23.119
1.00
24.90
A
C


ATOM
7189
CB
THR
A
452
36.752
−15.015
23.327
1.00
24.75
A
C


ATOM
7191
OG1
THR
A
452
36.470
−14.915
24.727
1.00
24.32
A
O


ATOM
7193
CG2
THR
A
452
36.021
−16.222
22.756
1.00
24.68
A
C


ATOM
7197
C
THR
A
452
38.560
−15.175
21.609
1.00
24.60
A
C


ATOM
7198
O
THR
A
452
38.318
−16.200
20.964
1.00
24.57
A
O


ATOM
7200
N
ALA
A
453
39.066
−14.073
21.049
1.00
23.97
A
N


ATOM
7201
CA
ALA
A
453
39.372
−13.991
19.613
1.00
23.32
A
C


ATOM
7203
CB
ALA
A
453
39.710
−12.550
19.216
1.00
23.40
A
C


ATOM
7207
C
ALA
A
453
40.515
−14.935
19.237
1.00
22.48
A
C


ATOM
7208
O
ALA
A
453
41.639
−14.504
18.962
1.00
22.66
A
O


ATOM
7210
N
ASN
A
454
40.201
−16.228
19.220
1.00
21.33
A
N


ATOM
7211
CA
ASN
A
454
41.191
−17.281
19.038
1.00
20.43
A
C


ATOM
7213
CB
ASN
A
454
42.047
−17.415
20.297
1.00
20.27
A
C


ATOM
7216
CG
ASN
A
454
43.269
−18.277
20.082
1.00
20.86
A
C


ATOM
7217
OD1
ASN
A
454
43.160
−19.454
19.740
1.00
22.12
A
O


ATOM
7218
ND2
ASN
A
454
44.445
−17.697
20.294
1.00
22.69
A
N


ATOM
7221
C
ASN
A
454
40.488
−18.602
18.733
1.00
19.67
A
C


ATOM
7222
O
ASN
A
454
39.513
−18.957
19.396
1.00
19.58
A
O


ATOM
7224
N
SER
A
455
40.986
−19.320
17.731
1.00
18.91
A
N


ATOM
7225
CA
SER
A
455
40.347
−20.549
17.264
1.00
18.58
A
C


ATOM
7227
CB
SER
A
455
41.080
−21.092
16.040
1.00
18.57
A
C


ATOM
7230
OG
SER
A
455
41.081
−20.136
14.995
1.00
18.90
A
O


ATOM
7232
C
SER
A
455
40.294
−21.619
18.348
1.00
18.43
A
C


ATOM
7233
O
SER
A
455
39.274
−22.289
18.517
1.00
18.43
A
O


ATOM
7235
N
VAL
A
456
41.395
−21.765
19.081
1.00
18.24
A
N


ATOM
7236
CA
VAL
A
456
41.476
−22.719
20.189
1.00
17.99
A
C


ATOM
7238
CB
VAL
A
456
42.896
−22.755
20.804
1.00
17.68
A
C


ATOM
7240
CG1
VAL
A
456
43.002
−23.866
21.837
1.00
17.09
A
C


ATOM
7244
CG2
VAL
A
456
43.950
−22.931
19.720
1.00
17.17
A
C


ATOM
7248
C
VAL
A
456
40.472
−22.360
21.290
1.00
18.30
A
C


ATOM
7249
O
VAL
A
456
39.855
−23.240
21.891
1.00
18.13
A
O


ATOM
7251
N
SER
A
457
40.314
−21.062
21.537
1.00
18.70
A
N


ATOM
7252
CA
SER
A
457
39.420
−20.564
22.579
1.00
18.75
A
C


ATOM
7254
CB
SER
A
457
39.593
−19.050
22.748
1.00
18.60
A
C


ATOM
7257
OG
SER
A
457
38.845
−18.568
23.849
1.00
19.53
A
O


ATOM
7259
C
SER
A
457
37.961
−20.887
22.276
1.00
18.84
A
C


ATOM
7260
O
SER
A
457
37.233
−21.352
23.151
1.00
19.03
A
O


ATOM
7262
N
CYS
A
458
37.540
−20.641
21.038
1.00
19.02
A
N


ATOM
7263
CA
CYS
A
458
36.150
−20.883
20.639
1.00
19.32
A
C


ATOM
7265
CB
CYS
A
458
35.820
−20.159
19.328
1.00
19.42
A
C


ATOM
7268
SG
CYS
A
458
35.508
−18.389
19.544
1.00
20.53
A
S


ATOM
7270
C
CYS
A
458
35.811
−22.373
20.530
1.00
19.33
A
C


ATOM
7271
O
CYS
A
458
34.639
−22.746
20.610
1.00
19.60
A
O


ATOM
7273
N
TYR
A
459
36.827
−23.218
20.355
1.00
19.09
A
N


ATOM
7274
CA
TYR
A
459
36.622
−24.666
20.365
1.00
18.87
A
C


ATOM
7276
CB
TYR
A
459
37.841
−25.402
19.805
1.00
18.80
A
C


ATOM
7279
CG
TYR
A
459
37.543
−26.809
19.320
1.00
17.90
A
C


ATOM
7280
CD1
TYR
A
459
37.163
−27.044
17.999
1.00
15.79
A
C


ATOM
7282
CE1
TYR
A
459
36.890
−28.327
17.546
1.00
15.20
A
C


ATOM
7284
CZ
TYR
A
459
36.998
−29.398
18.415
1.00
16.33
A
C


ATOM
7285
OH
TYR
A
459
36.728
−30.670
17.962
1.00
17.00
A
O


ATOM
7287
CE2
TYR
A
459
37.375
−29.194
19.734
1.00
16.42
A
C


ATOM
7289
CD2
TYR
A
459
37.646
−27.903
20.179
1.00
17.05
A
C


ATOM
7291
C
TYR
A
459
36.332
−25.124
21.792
1.00
19.29
A
C


ATOM
7292
O
TYR
A
459
35.353
−25.834
22.029
1.00
19.45
A
O


ATOM
7294
N
MET
A
460
37.182
−24.704
22.733
1.00
19.66
A
N


ATOM
7295
CA
MET
A
460
36.959
−24.942
24.166
1.00
20.09
A
C


ATOM
7297
CB
MET
A
460
37.907
−24.088
25.020
1.00
20.44
A
C


ATOM
7300
CG
MET
A
460
39.363
−24.535
25.035
1.00
21.37
A
C


ATOM
7303
SD
MET
A
460
40.403
−23.446
26.040
1.00
20.41
A
S


ATOM
7304
CE
MET
A
460
39.710
−23.720
27.672
1.00
20.51
A
C


ATOM
7308
C
MET
A
460
35.526
−24.602
24.568
1.00
20.02
A
C


ATOM
7309
O
MET
A
460
34.881
−25.354
25.299
1.00
20.55
A
O


ATOM
7311
N
ARG
A
461
35.044
−23.460
24.087
1.00
19.56
A
N


ATOM
7312
CA
ARG
A
461
33.701
−22.985
24.402
1.00
19.46
A
C


ATOM
7314
CB
ARG
A
461
33.576
−21.506
24.032
1.00
19.44
A
C


ATOM
7317
CG
ARG
A
461
32.316
−20.828
24.545
1.00
19.32
A
C


ATOM
7320
CD
ARG
A
461
32.420
−19.311
24.446
1.00
20.04
A
C


ATOM
7323
NE
ARG
A
461
32.757
−18.860
23.095
1.00
20.53
A
N


ATOM
7325
CZ
ARG
A
461
32.925
−17.587
22.743
1.00
21.06
A
C


ATOM
7326
NH1
ARG
A
461
32.781
−16.609
23.634
1.00
20.57
A
N


ATOM
7329
NH2
ARG
A
461
33.238
−17.287
21.486
1.00
22.20
A
N


ATOM
7332
C
ARG
A
461
32.622
−23.797
23.685
1.00
19.27
A
C


ATOM
7333
O
ARG
A
461
31.605
−24.142
24.283
1.00
19.05
A
O


ATOM
7335
N
THR
A
462
32.852
−24.099
22.409
1.00
19.32
A
N


ATOM
7336
CA
THR
A
462
31.871
−24.814
21.585
1.00
19.62
A
C


ATOM
7338
CB
THR
A
462
32.292
−24.821
20.095
1.00
19.63
A
C


ATOM
7340
OG1
THR
A
462
32.065
−23.524
19.532
1.00
20.66
A
O


ATOM
7342
CG2
THR
A
462
31.503
−25.854
19.296
1.00
20.05
A
C


ATOM
7346
C
THR
A
462
31.632
−26.253
22.052
1.00
19.82
A
C


ATOM
7347
O
THR
A
462
30.487
−26.719
22.084
1.00
20.00
A
O


ATOM
7349
N
LYS
A
463
32.710
−26.948
22.413
1.00
19.62
A
N


ATOM
7350
CA
LYS
A
463
32.622
−28.345
22.846
1.00
19.23
A
C


ATOM
7352
CB
LYS
A
463
33.772
−29.162
22.243
1.00
19.10
A
C


ATOM
7355
CG
LYS
A
463
34.023
−28.923
20.754
1.00
17.85
A
C


ATOM
7358
CD
LYS
A
463
32.791
−29.169
19.891
1.00
17.09
A
C


ATOM
7361
CE
LYS
A
463
33.108
−28.934
18.419
1.00
17.67
A
C


ATOM
7364
NZ
LYS
A
463
31.897
−28.942
17.554
1.00
18.35
A
N


ATOM
7368
C
LYS
A
463
32.618
−28.499
24.374
1.00
19.01
A
C


ATOM
7369
O
LYS
A
463
32.385
−29.597
24.883
1.00
18.88
A
O


ATOM
7371
N
GLY
A
464
32.875
−27.407
25.095
1.00
18.78
A
N


ATOM
7372
CA
GLY
A
464
32.929
−27.434
26.557
1.00
18.68
A
C


ATOM
7375
C
GLY
A
464
34.040
−28.331
27.067
1.00
18.63
A
C


ATOM
7376
O
GLY
A
464
33.780
−29.294
27.790
1.00
18.57
A
O


ATOM
7378
N
ILE
A
465
35.278
−28.015
26.685
1.00
18.68
A
N


ATOM
7379
CA
ILE
A
465
36.439
−28.853
27.006
1.00
18.82
A
C


ATOM
7381
CB
ILE
A
465
36.788
−29.812
25.838
1.00
18.83
A
C


ATOM
7383
CG1
ILE
A
465
37.004
−29.035
24.534
1.00
18.84
A
C


ATOM
7386
CD1
ILE
A
465
37.345
−29.915
23.345
1.00
18.16
A
C


ATOM
7390
CG2
ILE
A
465
35.689
−30.848
25.660
1.00
19.72
A
C


ATOM
7394
C
ILE
A
465
37.682
−28.039
27.370
1.00
18.85
A
C


ATOM
7395
O
ILE
A
465
37.736
−26.826
27.153
1.00
18.44
A
O


ATOM
7397
N
SER
A
466
38.676
−28.731
27.920
1.00
19.23
A
N


ATOM
7398
CA
SER
A
466
39.912
−28.108
28.384
1.00
19.68
A
C


ATOM
7400
CB
SER
A
466
40.667
−29.071
29.304
1.00
19.87
A
C


ATOM
7403
OG
SER
A
466
40.980
−30.278
28.628
1.00
19.96
A
O


ATOM
7405
C
SER
A
466
40.811
−27.707
27.221
1.00
20.03
A
C


ATOM
7406
O
SER
A
466
40.670
−28.225
26.114
1.00
19.89
A
O


ATOM
7408
N
GLU
A
467
41.746
−26.797
27.491
1.00
20.78
A
N


ATOM
7409
CA
GLU
A
467
42.673
−26.283
26.472
1.00
21.37
A
C


ATOM
7411
CB
GLU
A
467
43.576
−25.189
27.062
1.00
21.42
A
C


ATOM
7414
CG
GLU
A
467
44.408
−24.433
26.022
1.00
21.87
A
C


ATOM
7417
CD
GLU
A
467
45.487
−23.565
26.640
1.00
22.82
A
C


ATOM
7418
OE1
GLU
A
467
45.207
−22.883
27.647
1.00
23.89
A
O


ATOM
7419
OE2
GLU
A
467
46.618
−23.560
26.109
1.00
23.99
A
O


ATOM
7420
C
GLU
A
467
43.542
−27.377
25.843
1.00
21.81
A
C


ATOM
7421
O
GLU
A
467
43.856
−27.309
24.651
1.00
22.00
A
O


ATOM
7423
N
GLU
A
468
43.932
−28.373
26.639
1.00
21.90
A
N


ATOM
7424
CA
GLU
A
468
44.772
−29.466
26.142
1.00
21.88
A
C


ATOM
7426
CB
GLU
A
468
45.304
−30.320
27.298
1.00
22.13
A
C


ATOM
7429
CG
GLU
A
468
46.361
−31.336
26.869
1.00
23.30
A
C


ATOM
7432
CD
GLU
A
468
46.846
−32.207
28.012
1.00
24.29
A
C


ATOM
7433
OE1
GLU
A
468
47.560
−31.688
28.898
1.00
25.02
A
O


ATOM
7434
OE2
GLU
A
468
46.526
−33.416
28.015
1.00
24.63
A
O


ATOM
7435
C
GLU
A
468
44.022
−30.345
25.137
1.00
21.46
A
C


ATOM
7436
O
GLU
A
468
44.577
−30.710
24.099
1.00
21.21
A
O


ATOM
7438
N
LEU
A
469
42.771
−30.685
25.450
1.00
21.18
A
N


ATOM
7439
CA
LEU
A
469
41.919
−31.458
24.531
1.00
20.84
A
C


ATOM
7441
CB
LEU
A
469
40.692
−32.042
25.253
1.00
21.05
A
C


ATOM
7444
CG
LEU
A
469
40.856
−33.409
25.932
1.00
20.32
A
C


ATOM
7446
CD1
LEU
A
469
41.842
−33.328
27.086
1.00
20.20
A
C


ATOM
7450
CD2
LEU
A
469
39.508
−33.940
26.415
1.00
18.12
A
C


ATOM
7454
C
LEU
A
469
41.463
−30.616
23.335
1.00
20.25
A
C


ATOM
7455
O
LEU
A
469
41.262
−31.149
22.243
1.00
20.27
A
O


ATOM
7457
N
ALA
A
470
41.295
−29.312
23.550
1.00
19.59
A
N


ATOM
7458
CA
ALA
A
470
40.901
−28.386
22.484
1.00
19.19
A
C


ATOM
7460
CB
ALA
A
470
40.517
−27.037
23.069
1.00
18.89
A
C


ATOM
7464
C
ALA
A
470
42.013
−28.213
21.452
1.00
19.15
A
C


ATOM
7465
O
ALA
A
470
41.746
−28.143
20.249
1.00
19.34
A
O


ATOM
7467
N
THR
A
471
43.254
−28.135
21.931
1.00
18.89
A
N


ATOM
7468
CA
THR
A
471
44.426
−28.064
21.059
1.00
18.62
A
C


ATOM
7470
CB
THR
A
471
45.732
−27.906
21.884
1.00
18.76
A
C


ATOM
7472
OG1
THR
A
471
45.777
−26.597
22.467
1.00
19.40
A
O


ATOM
7474
CG2
THR
A
471
46.968
−28.103
21.012
1.00
18.57
A
C


ATOM
7478
C
THR
A
471
44.515
−29.311
20.179
1.00
18.43
A
C


ATOM
7479
O
THR
A
471
44.622
−29.205
18.959
1.00
18.22
A
O


ATOM
7481
N
GLU
A
472
44.446
−30.484
20.807
1.00
18.49
A
N


ATOM
7482
CA
GLU
A
472
44.564
−31.770
20.107
1.00
18.66
A
C


ATOM
7484
CB
GLU
A
472
44.382
−32.928
21.094
1.00
18.91
A
C


ATOM
7487
CG
GLU
A
472
44.713
−34.306
20.517
1.00
20.49
A
C


ATOM
7490
CD
GLU
A
472
44.356
−35.452
21.450
1.00
21.71
A
C


ATOM
7491
OE1
GLU
A
472
44.795
−36.589
21.175
1.00
22.68
A
O


ATOM
7492
OE2
GLU
A
472
43.637
−35.225
22.448
1.00
22.86
A
O


ATOM
7493
C
GLU
A
472
43.569
−31.924
18.951
1.00
18.52
A
C


ATOM
7494
O
GLU
A
472
43.896
−32.510
17.917
1.00
17.98
A
O


ATOM
7496
N
SER
A
473
42.356
−31.410
19.133
1.00
18.86
A
N


ATOM
7497
CA
SER
A
473
41.343
−31.440
18.077
1.00
19.17
A
C


ATOM
7499
CB
SER
A
473
39.978
−31.041
18.633
1.00
18.98
A
C


ATOM
7502
OG
SER
A
473
39.616
−31.871
19.723
1.00
18.35
A
O


ATOM
7504
C
SER
A
473
41.727
−30.519
16.917
1.00
19.64
A
C


ATOM
7505
O
SER
A
473
41.518
−30.862
15.749
1.00
20.03
A
O


ATOM
7507
N
VAL
A
474
42.287
−29.355
17.248
1.00
19.48
A
N


ATOM
7508
CA
VAL
A
474
42.797
−28.424
16.240
1.00
19.38
A
C


ATOM
7510
CB
VAL
A
474
43.148
−27.054
16.862
1.00
19.33
A
C


ATOM
7512
CG1
VAL
A
474
43.833
−26.152
15.844
1.00
18.11
A
C


ATOM
7516
CG2
VAL
A
474
41.892
−26.389
17.412
1.00
19.60
A
C


ATOM
7520
C
VAL
A
474
44.020
−29.008
15.525
1.00
19.69
A
C


ATOM
7521
O
VAL
A
474
44.175
−28.829
14.315
1.00
20.15
A
O


ATOM
7523
N
MET
A
475
44.873
−29.714
16.268
1.00
19.66
A
N


ATOM
7524
CA
MET
A
475
46.005
−30.444
15.680
1.00
19.70
A
C


ATOM
7526
CB
MET
A
475
46.889
−31.053
16.772
1.00
20.05
A
C


ATOM
7529
CG
MET
A
475
47.604
−30.045
17.650
1.00
20.04
A
C


ATOM
7532
SD
MET
A
475
48.893
−29.161
16.773
1.00
21.08
A
S


ATOM
7533
CE
MET
A
475
50.090
−28.966
18.096
1.00
21.33
A
C


ATOM
7537
C
MET
A
475
45.528
−31.562
14.751
1.00
19.35
A
C


ATOM
7538
O
MET
A
475
46.147
−31.822
13.718
1.00
19.12
A
O


ATOM
7540
N
ASN
A
476
44.441
−32.230
15.136
1.00
19.22
A
N


ATOM
7541
CA
ASN
A
476
43.791
−33.215
14.270
1.00
19.31
A
C


ATOM
7543
CB
ASN
A
476
42.729
−34.021
15.036
1.00
19.59
A
C


ATOM
7546
CG
ASN
A
476
43.330
−35.106
15.920
1.00
20.46
A
C


ATOM
7547
OD1
ASN
A
476
44.375
−35.682
15.605
1.00
21.67
A
O


ATOM
7548
ND2
ASN
A
476
42.659
−35.397
17.029
1.00
19.15
A
N


ATOM
7551
C
ASN
A
476
43.147
−32.565
13.050
1.00
18.81
A
C


ATOM
7552
O
ASN
A
476
43.056
−33.193
11.996
1.00
19.00
A
O


ATOM
7554
N
LEU
A
477
42.699
−31.318
13.195
1.00
18.29
A
N


ATOM
7555
CA
LEU
A
477
42.084
−30.588
12.083
1.00
18.10
A
C


ATOM
7557
CB
LEU
A
477
41.349
−29.331
12.568
1.00
18.33
A
C


ATOM
7560
CG
LEU
A
477
40.013
−29.097
11.847
1.00
19.37
A
C


ATOM
7562
CD1
LEU
A
477
38.911
−29.923
12.515
1.00
19.86
A
C


ATOM
7566
CD2
LEU
A
477
39.627
−27.623
11.809
1.00
19.63
A
C


ATOM
7570
C
LEU
A
477
43.115
−30.208
11.022
1.00
17.36
A
C


ATOM
7571
O
LEU
A
477
42.808
−30.206
9.834
1.00
16.65
A
O


ATOM
7573
N
ILE
A
478
44.328
−29.876
11.459
1.00
17.33
A
N


ATOM
7574
CA
ILE
A
478
45.438
−29.615
10.540
1.00
17.10
A
C


ATOM
7576
CB
ILE
A
478
46.684
−29.070
11.278
1.00
16.99
A
C


ATOM
7578
CG1
ILE
A
478
46.479
−27.597
11.646
1.00
15.91
A
C


ATOM
7581
CD1
ILE
A
478
47.583
−27.015
12.513
1.00
14.00
A
C


ATOM
7585
CG2
ILE
A
478
47.928
−29.216
10.418
1.00
16.35
A
C


ATOM
7589
C
ILE
A
478
45.797
−30.895
9.796
1.00
17.29
A
C


ATOM
7590
O
ILE
A
478
45.765
−30.928
8.566
1.00
16.88
A
O


ATOM
7592
N
ASP
A
479
46.124
−31.946
10.547
1.00
17.99
A
N


ATOM
7593
CA
ASP
A
479
46.388
−33.264
9.962
1.00
18.84
A
C


ATOM
7595
CB
ASP
A
479
46.434
−34.355
11.047
1.00
19.10
A
C


ATOM
7598
CG
ASP
A
479
47.715
−34.320
11.885
1.00
20.09
A
C


ATOM
7599
OD1
ASP
A
479
48.759
−33.837
11.398
1.00
23.06
A
O


ATOM
7600
OD2
ASP
A
479
47.678
−34.799
13.039
1.00
20.40
A
O


ATOM
7601
C
ASP
A
479
45.316
−33.616
8.926
1.00
19.15
A
C


ATOM
7602
O
ASP
A
479
45.633
−34.020
7.807
1.00
19.09
A
O


ATOM
7604
N
GLU
A
480
44.052
−33.439
9.307
1.00
19.60
A
N


ATOM
7605
CA
GLU
A
480
42.914
−33.728
8.431
1.00
19.98
A
C


ATOM
7607
CB
GLU
A
480
41.602
−33.582
9.207
1.00
19.86
A
C


ATOM
7610
CG
GLU
A
480
40.347
−33.858
8.393
1.00
20.57
A
C


ATOM
7613
CD
GLU
A
480
39.126
−34.088
9.268
1.00
22.39
A
C


ATOM
7614
OE1
GLU
A
480
39.083
−35.116
9.982
1.00
22.35
A
O


ATOM
7615
OE2
GLU
A
480
38.205
−33.244
9.233
1.00
22.18
A
O


ATOM
7616
C
GLU
A
480
42.885
−32.835
7.190
1.00
20.39
A
C


ATOM
7617
O
GLU
A
480
42.571
−33.303
6.095
1.00
20.59
A
O


ATOM
7619
N
THR
A
481
43.202
−31.553
7.364
1.00
20.68
A
N


ATOM
7620
CA
THR
A
481
43.218
−30.604
6.249
1.00
20.31
A
C


ATOM
7622
CB
THR
A
481
43.298
−29.143
6.737
1.00
20.04
A
C


ATOM
7624
OG1
THR
A
481
42.259
−28.899
7.690
1.00
20.12
A
O


ATOM
7626
CG2
THR
A
481
43.131
−28.179
5.577
1.00
19.56
A
C


ATOM
7630
C
THR
A
481
44.378
−30.897
5.297
1.00
20.57
A
C


ATOM
7631
O
THR
A
481
44.217
−30.791
4.080
1.00
21.43
A
O


ATOM
7633
N
TRP
A
482
45.537
−31.268
5.846
1.00
19.91
A
N


ATOM
7634
CA
TRP
A
482
46.673
−31.698
5.020
1.00
19.35
A
C


ATOM
7636
CB
TRP
A
482
47.922
−31.978
5.873
1.00
19.46
A
C


ATOM
7639
CG
TRP
A
482
48.839
−30.798
5.995
1.00
19.49
A
C


ATOM
7640
CD1
TRP
A
482
48.961
−29.963
7.064
1.00
19.76
A
C


ATOM
7642
NE1
TRP
A
482
49.900
−28.996
6.805
1.00
18.99
A
N


ATOM
7644
CE2
TRP
A
482
50.403
−29.191
5.547
1.00
19.41
A
C


ATOM
7645
CD2
TRP
A
482
49.757
−30.320
5.005
1.00
18.58
A
C


ATOM
7646
CE3
TRP
A
482
50.095
−30.737
3.714
1.00
18.27
A
C


ATOM
7648
CZ3
TRP
A
482
51.055
−30.024
3.014
1.00
19.21
A
C


ATOM
7650
CH2
TRP
A
482
51.681
−28.902
3.581
1.00
20.66
A
C


ATOM
7652
CZ2
TRP
A
482
51.369
−28.470
4.842
1.00
19.87
A
C


ATOM
7654
C
TRP
A
482
46.333
−32.933
4.186
1.00
18.89
A
C


ATOM
7655
O
TRP
A
482
46.780
−33.055
3.048
1.00
18.56
A
O


ATOM
7657
N
LYS
A
483
45.544
−33.842
4.753
1.00
18.60
A
N


ATOM
7658
CA
LYS
A
483
45.126
−35.045
4.034
1.00
18.61
A
C


ATOM
7660
CB
LYS
A
483
44.344
−35.996
4.953
1.00
18.82
A
C


ATOM
7663
CG
LYS
A
483
45.198
−36.750
5.972
1.00
17.67
A
C


ATOM
7666
CD
LYS
A
483
44.331
−37.423
7.032
1.00
15.32
A
C


ATOM
7669
CE
LYS
A
483
45.158
−38.283
7.970
1.00
13.29
A
C


ATOM
7672
NZ
LYS
A
483
44.317
−38.976
8.975
1.00
11.47
A
N


ATOM
7676
C
LYS
A
483
44.288
−34.699
2.803
1.00
18.60
A
C


ATOM
7677
O
LYS
A
483
44.480
−35.279
1.737
1.00
19.08
A
O


ATOM
7679
N
LYS
A
484
43.365
−33.755
2.953
1.00
18.44
A
N


ATOM
7680
CA
LYS
A
484
42.497
−33.350
1.848
1.00
18.75
A
C


ATOM
7682
CB
LYS
A
484
41.273
−32.596
2.375
1.00
19.23
A
C


ATOM
7685
CG
LYS
A
484
40.298
−33.472
3.160
1.00
20.08
A
C


ATOM
7688
CD
LYS
A
484
39.154
−32.644
3.749
1.00
21.14
A
C


ATOM
7691
CE
LYS
A
484
38.400
−33.410
4.825
1.00
21.14
A
C


ATOM
7694
NZ
LYS
A
484
37.453
−32.542
5.575
1.00
21.03
A
N


ATOM
7698
C
LYS
A
484
43.229
−32.506
0.799
1.00
18.54
A
C


ATOM
7699
O
LYS
A
484
42.816
−32.464
−0.362
1.00
18.32
A
O


ATOM
7701
N
MET
A
485
44.303
−31.832
1.206
1.00
18.57
A
N


ATOM
7702
CA
MET
A
485
45.123
−31.055
0.271
1.00
18.64
A
C


ATOM
7704
CB
MET
A
485
45.980
−30.024
1.012
1.00
18.40
A
C


ATOM
7707
CG
MET
A
485
45.227
−28.776
1.434
1.00
18.70
A
C


ATOM
7710
SD
MET
A
485
46.323
−27.453
1.994
1.00
20.00
A
S


ATOM
7711
CE
MET
A
485
47.030
−28.185
3.470
1.00
21.42
A
C


ATOM
7715
C
MET
A
485
46.018
−31.957
−0.579
1.00
18.87
A
C


ATOM
7716
O
MET
A
485
46.335
−31.620
−1.718
1.00
19.09
A
O


ATOM
7718
N
ASN
A
486
46.423
−33.097
−0.024
1.00
19.18
A
N


ATOM
7719
CA
ASN
A
486
47.263
−34.055
−0.747
1.00
19.51
A
C


ATOM
7721
CB
ASN
A
486
47.949
−35.011
0.234
1.00
19.57
A
C


ATOM
7724
CG
ASN
A
486
48.863
−34.291
1.215
1.00
18.76
A
C


ATOM
7725
OD1
ASN
A
486
49.319
−33.176
0.955
1.00
16.76
A
O


ATOM
7726
ND2
ASN
A
486
49.129
−34.926
2.353
1.00
15.82
A
N


ATOM
7729
C
ASN
A
486
46.484
−34.844
−1.805
1.00
19.93
A
C


ATOM
7730
O
ASN
A
486
47.079
−35.465
−2.686
1.00
19.71
A
O


ATOM
7732
N
LYS
A
487
45.157
−34.825
−1.699
1.00
20.76
A
N


ATOM
7733
CA
LYS
A
487
44.270
−35.350
−2.740
1.00
21.38
A
C


ATOM
7735
CB
LYS
A
487
42.876
−35.618
−2.155
1.00
21.37
A
C


ATOM
7738
CG
LYS
A
487
41.863
−36.168
−3.146
1.00
22.41
A
C


ATOM
7741
CD
LYS
A
487
40.657
−36.762
−2.429
1.00
24.55
A
C


ATOM
7744
CE
LYS
A
487
39.699
−37.429
−3.406
1.00
25.58
A
C


ATOM
7747
NZ
LYS
A
487
38.641
−38.214
−2.712
1.00
25.77
A
N


ATOM
7751
C
LYS
A
487
44.173
−34.357
−3.902
1.00
21.61
A
C


ATOM
7752
O
LYS
A
487
44.198
−34.750
−5.069
1.00
21.31
A
O


ATOM
7754
N
GLU
A
488
44.066
−33.073
−3.563
1.00
22.02
A
N


ATOM
7755
CA
GLU
A
488
43.961
−31.991
−4.548
1.00
22.50
A
C


ATOM
7757
CB
GLU
A
488
43.814
−30.642
−3.829
1.00
22.80
A
C


ATOM
7760
CG
GLU
A
488
43.213
−29.533
−4.676
1.00
23.18
A
C


ATOM
7763
CD
GLU
A
488
41.700
−29.614
−4.749
1.00
24.54
A
C


ATOM
7764
OE1
GLU
A
488
41.174
−30.005
−5.813
1.00
26.04
A
O


ATOM
7765
OE2
GLU
A
488
41.037
−29.300
−3.736
1.00
23.72
A
O


ATOM
7766
C
GLU
A
488
45.175
−31.939
−5.484
1.00
22.62
A
C


ATOM
7767
O
GLU
A
488
45.030
−31.728
−6.692
1.00
22.91
A
O


ATOM
7769
N
LYS
A
489
46.364
−32.126
−4.914
1.00
22.30
A
N


ATOM
7770
CA
LYS
A
489
47.612
−32.113
−5.679
1.00
22.00
A
C


ATOM
7772
CB
LYS
A
489
48.811
−32.096
−4.722
1.00
21.67
A
C


ATOM
7775
CG
LYS
A
489
50.184
−32.043
−5.393
1.00
21.43
A
C


ATOM
7778
CD
LYS
A
489
50.461
−30.695
−6.050
1.00
20.14
A
C


ATOM
7781
CE
LYS
A
489
51.730
−30.743
−6.890
1.00
19.82
A
C


ATOM
7784
NZ
LYS
A
489
52.931
−31.125
−6.095
1.00
17.92
A
N


ATOM
7788
C
LYS
A
489
47.701
−33.322
−6.611
1.00
22.11
A
C


ATOM
7789
O
LYS
A
489
48.096
−33.198
−7.773
1.00
21.65
A
O


ATOM
7791
N
LEU
A
490
47.327
−34.488
−6.093
1.00
22.42
A
N


ATOM
7792
CA
LEU
A
490
47.446
−35.738
−6.839
1.00
22.44
A
C


ATOM
7794
CB
LEU
A
490
47.168
−36.947
−5.931
1.00
22.44
A
C


ATOM
7797
CG
LEU
A
490
47.979
−38.212
−6.227
1.00
21.83
A
C


ATOM
7799
CD1
LEU
A
490
49.430
−38.021
−5.803
1.00
20.81
A
C


ATOM
7803
CD2
LEU
A
490
47.375
−39.425
−5.528
1.00
22.00
A
C


ATOM
7807
C
LEU
A
490
46.513
−35.751
−8.049
1.00
22.61
A
C


ATOM
7808
O
LEU
A
490
46.851
−36.327
−9.084
1.00
22.97
A
O


ATOM
7810
N
GLY
A
491
45.347
−35.118
−7.919
1.00
22.59
A
N


ATOM
7811
CA
GLY
A
491
44.416
−35.003
−9.038
1.00
22.92
A
C


ATOM
7814
C
GLY
A
491
43.025
−34.538
−8.654
1.00
23.38
A
C


ATOM
7815
O
GLY
A
491
42.667
−34.519
−7.479
1.00
23.58
A
O


ATOM
7817
N
GLY
A
492
42.242
−34.164
−9.662
1.00
24.00
A
N


ATOM
7818
CA
GLY
A
492
40.868
−33.719
−9.464
1.00
24.68
A
C


ATOM
7821
C
GLY
A
492
40.714
−32.217
−9.284
1.00
25.47
A
C


ATOM
7822
O
GLY
A
492
39.590
−31.710
−9.219
1.00
26.12
A
O


ATOM
7824
N
SER
A
493
41.829
−31.495
−9.204
1.00
25.71
A
N


ATOM
7825
CA
SER
A
493
41.777
−30.049
−9.019
1.00
25.75
A
C


ATOM
7827
CB
SER
A
493
43.159
−29.494
−8.656
1.00
26.12
A
C


ATOM
7830
OG
SER
A
493
43.108
−28.096
−8.407
1.00
25.68
A
O


ATOM
7832
C
SER
A
493
41.268
−29.373
−10.287
1.00
25.36
A
C


ATOM
7833
O
SER
A
493
41.558
−29.836
−11.390
1.00
25.36
A
O


ATOM
7835
N
PRO
A
494
40.493
−28.285
−10.134
1.00
25.03
A
N


ATOM
7836
CA
PRO
A
494
40.128
−27.456
−11.280
1.00
24.84
A
C


ATOM
7838
CB
PRO
A
494
38.930
−26.657
−10.766
1.00
24.98
A
C


ATOM
7841
CG
PRO
A
494
39.143
−26.559
−9.306
1.00
25.14
A
C


ATOM
7844
CD
PRO
A
494
39.871
−27.804
−8.887
1.00
25.07
A
C


ATOM
7847
C
PRO
A
494
41.269
−26.525
−11.699
1.00
24.33
A
C


ATOM
7848
O
PRO
A
494
41.251
−25.992
−12.809
1.00
24.46
A
O


ATOM
7849
N
PHE
A
495
42.242
−26.332
−10.809
1.00
23.65
A
N


ATOM
7850
CA
PHE
A
495
43.440
−25.554
−11.110
1.00
23.36
A
C


ATOM
7852
CB
PHE
A
495
43.903
−24.783
−9.872
1.00
23.58
A
C


ATOM
7855
CG
PHE
A
495
42.904
−23.784
−9.374
1.00
23.05
A
C


ATOM
7856
CD1
PHE
A
495
42.977
−22.457
−9.760
1.00
21.76
A
C


ATOM
7858
CE1
PHE
A
495
42.052
−21.539
−9.302
1.00
22.61
A
C


ATOM
7860
CZ
PHE
A
495
41.036
−21.946
−8.454
1.00
22.69
A
C


ATOM
7862
CE2
PHE
A
495
40.953
−23.264
−8.068
1.00
23.16
A
C


ATOM
7864
CD2
PHE
A
495
41.883
−24.175
−8.525
1.00
23.51
A
C


ATOM
7866
C
PHE
A
495
44.561
−26.470
−11.576
1.00
23.05
A
C


ATOM
7867
O
PHE
A
495
44.538
−27.676
−11.325
1.00
22.76
A
O


ATOM
7869
N
ALA
A
496
45.545
−25.886
−12.253
1.00
22.91
A
N


ATOM
7870
CA
ALA
A
496
46.730
−26.622
−12.677
1.00
22.83
A
C


ATOM
7872
CB
ALA
A
496
47.528
−25.806
−13.681
1.00
23.00
A
C


ATOM
7876
C
ALA
A
496
47.586
−26.957
−11.461
1.00
22.74
A
C


ATOM
7877
O
ALA
A
496
47.573
−26.229
−10.469
1.00
23.03
A
O


ATOM
7879
N
LYS
A
497
48.331
−28.056
−11.544
1.00
22.67
A
N


ATOM
7880
CA
LYS
A
497
49.160
−28.523
−10.424
1.00
22.50
A
C


ATOM
7882
CB
LYS
A
497
49.887
−29.828
−10.785
1.00
22.80
A
C


ATOM
7885
CG
LYS
A
497
48.946
−31.004
−11.042
1.00
24.08
A
C


ATOM
7888
CD
LYS
A
497
49.679
−32.344
−11.050
1.00
24.82
A
C


ATOM
7891
CE
LYS
A
497
48.703
−33.508
−11.215
1.00
24.18
A
C


ATOM
7894
NZ
LYS
A
497
49.301
−34.815
−10.828
1.00
23.44
A
N


ATOM
7898
C
LYS
A
497
50.161
−27.474
−9.917
1.00
21.54
A
C


ATOM
7899
O
LYS
A
497
50.391
−27.385
−8.712
1.00
21.63
A
O


ATOM
7901
N
PRO
A
498
50.763
−26.684
−10.828
1.00
20.42
A
N


ATOM
7902
CA
PRO
A
498
51.606
−25.575
−10.392
1.00
19.81
A
C


ATOM
7904
CB
PRO
A
498
51.853
−24.807
−11.689
1.00
20.02
A
C


ATOM
7907
CG
PRO
A
498
51.868
−25.858
−12.730
1.00
20.71
A
C


ATOM
7910
CD
PRO
A
498
50.921
−26.940
−12.272
1.00
20.44
A
C


ATOM
7913
C
PRO
A
498
50.954
−24.665
−9.353
1.00
19.16
A
C


ATOM
7914
O
PRO
A
498
51.549
−24.416
−8.304
1.00
19.10
A
O


ATOM
7915
N
PHE
A
499
49.745
−24.184
−9.636
1.00
18.41
A
N


ATOM
7916
CA
PHE
A
499
49.067
−23.259
−8.725
1.00
17.71
A
C


ATOM
7918
CB
PHE
A
499
47.876
−22.577
−9.394
1.00
17.65
A
C


ATOM
7921
CG
PHE
A
499
47.125
−21.666
−8.469
1.00
17.11
A
C


ATOM
7922
CD1
PHE
A
499
47.733
−20.525
−7.964
1.00
15.75
A
C


ATOM
7924
CE1
PHE
A
499
47.059
−19.686
−7.097
1.00
16.82
A
C


ATOM
7926
CZ
PHE
A
499
45.760
−19.985
−6.715
1.00
18.26
A
C


ATOM
7928
CE2
PHE
A
499
45.146
−21.128
−7.203
1.00
19.35
A
C


ATOM
7930
CD2
PHE
A
499
45.833
−21.966
−8.071
1.00
18.48
A
C


ATOM
7932
C
PHE
A
499
48.594
−23.918
−7.432
1.00
17.27
A
C


ATOM
7933
O
PHE
A
499
48.608
−23.283
−6.377
1.00
18.04
A
O


ATOM
7935
N
VAL
A
500
48.156
−25.173
−7.520
1.00
16.13
A
N


ATOM
7936
CA
VAL
A
500
47.787
−25.947
−6.334
1.00
15.18
A
C


ATOM
7938
CB
VAL
A
500
47.344
−27.381
−6.710
1.00
15.13
A
C


ATOM
7940
CG1
VAL
A
500
46.049
−27.346
−7.503
1.00
15.59
A
C


ATOM
7944
CG2
VAL
A
500
47.181
−28.247
−5.466
1.00
15.76
A
C


ATOM
7948
C
VAL
A
500
48.972
−26.003
−5.367
1.00
14.53
A
C


ATOM
7949
O
VAL
A
500
48.834
−25.683
−4.184
1.00
14.32
A
O


ATOM
7951
N
GLU
A
501
50.134
−26.391
−5.893
1.00
13.78
A
N


ATOM
7952
CA
GLU
A
501
51.380
−26.469
−5.126
1.00
13.17
A
C


ATOM
7954
CB
GLU
A
501
52.516
−26.953
−6.033
1.00
13.27
A
C


ATOM
7957
CG
GLU
A
501
53.883
−27.124
−5.355
1.00
12.99
A
C


ATOM
7960
CD
GLU
A
501
53.936
−28.270
−4.360
1.00
10.75
A
C


ATOM
7961
OE1
GLU
A
501
53.035
−29.135
−4.365
1.00
9.48
A
O


ATOM
7962
OE2
GLU
A
501
54.899
−28.308
−3.571
1.00
9.39
A
O


ATOM
7963
C
GLU
A
501
51.759
−25.126
−4.505
1.00
13.02
A
C


ATOM
7964
O
GLU
A
501
52.309
−25.083
−3.403
1.00
12.70
A
O


ATOM
7966
N
THR
A
502
51.479
−24.037
−5.218
1.00
13.13
A
N


ATOM
7967
CA
THR
A
502
51.715
−22.696
−4.689
1.00
12.94
A
C


ATOM
7969
CB
THR
A
502
51.408
−21.597
−5.724
1.00
12.49
A
C


ATOM
7971
OG1
THR
A
502
51.913
−21.986
−7.007
1.00
12.30
A
O


ATOM
7973
CG2
THR
A
502
52.045
−20.281
−5.314
1.00
11.05
A
C


ATOM
7977
C
THR
A
502
50.849
−22.481
−3.453
1.00
13.75
A
C


ATOM
7978
O
THR
A
502
51.323
−21.947
−2.451
1.00
14.63
A
O


ATOM
7980
N
ALA
A
503
49.587
−22.912
−3.526
1.00
13.85
A
N


ATOM
7981
CA
ALA
A
503
48.671
−22.838
−2.386
1.00
13.85
A
C


ATOM
7983
CB
ALA
A
503
47.298
−23.367
−2.766
1.00
13.55
A
C


ATOM
7987
C
ALA
A
503
49.229
−23.619
−1.202
1.00
14.25
A
C


ATOM
7988
O
ALA
A
503
49.414
−23.068
−0.115
1.00
14.42
A
O


ATOM
7990
N
ILE
A
504
49.517
−24.899
−1.426
1.00
14.43
A
N


ATOM
7991
CA
ILE
A
504
50.082
−25.762
−0.385
1.00
14.49
A
C


ATOM
7993
CB
ILE
A
504
50.462
−27.159
−0.950
1.00
14.26
A
C


ATOM
7995
CG1
ILE
A
504
49.197
−27.968
−1.258
1.00
13.75
A
C


ATOM
7998
CD1
ILE
A
504
49.450
−29.249
−2.022
1.00
11.62
A
C


ATOM
8002
CG2
ILE
A
504
51.333
−27.928
0.032
1.00
13.71
A
C


ATOM
8006
C
ILE
A
504
51.293
−25.097
0.278
1.00
15.04
A
C


ATOM
8007
O
ILE
A
504
51.449
−25.159
1.498
1.00
15.26
A
O


ATOM
8009
N
ASN
A
505
52.125
−24.438
−0.526
1.00
15.57
A
N


ATOM
8010
CA
ASN
A
505
53.295
−23.716
−0.014
1.00
16.27
A
C


ATOM
8012
CB
ASN
A
505
54.117
−23.135
−1.175
1.00
16.20
A
C


ATOM
8015
CG
ASN
A
505
54.937
−24.191
−1.910
1.00
16.68
A
C


ATOM
8016
OD1
ASN
A
505
55.408
−25.164
−1.317
1.00
14.13
A
O


ATOM
8017
ND2
ASN
A
505
55.122
−23.989
−3.213
1.00
16.63
A
N


ATOM
8020
C
ASN
A
505
52.973
−22.607
1.014
1.00
16.76
A
C


ATOM
8021
O
ASN
A
505
53.840
−22.239
1.811
1.00
17.12
A
O


ATOM
8023
N
LEU
A
506
51.749
−22.074
0.995
1.00
16.63
A
N


ATOM
8024
CA
LEU
A
506
51.303
−21.135
2.034
1.00
16.26
A
C


ATOM
8026
CB
LEU
A
506
49.936
−20.530
1.694
1.00
16.36
A
C


ATOM
8029
CG
LEU
A
506
49.433
−19.409
2.615
1.00
15.61
A
C


ATOM
8031
CD1
LEU
A
506
50.134
−18.100
2.305
1.00
16.15
A
C


ATOM
8035
CD2
LEU
A
506
47.930
−19.241
2.488
1.00
15.78
A
C


ATOM
8039
C
LEU
A
506
51.220
−21.858
3.373
1.00
16.06
A
C


ATOM
8040
O
LEU
A
506
51.719
−21.363
4.387
1.00
15.94
A
O


ATOM
8042
N
ALA
A
507
50.582
−23.028
3.367
1.00
15.76
A
N


ATOM
8043
CA
ALA
A
507
50.483
−23.862
4.563
1.00
15.58
A
C


ATOM
8045
CB
ALA
A
507
49.733
−25.148
4.257
1.00
15.54
A
C


ATOM
8049
C
ALA
A
507
51.867
−24.178
5.109
1.00
15.59
A
C


ATOM
8050
O
ALA
A
507
52.095
−24.098
6.316
1.00
14.90
A
O


ATOM
8052
N
ARG
A
508
52.787
−24.531
4.210
1.00
16.16
A
N


ATOM
8053
CA
ARG
A
508
54.174
−24.806
4.585
1.00
16.29
A
C


ATOM
8055
CB
ARG
A
508
55.026
−25.165
3.364
1.00
16.26
A
C


ATOM
8058
CG
ARG
A
508
54.660
−26.473
2.679
1.00
17.94
A
C


ATOM
8061
CD
ARG
A
508
55.608
−26.763
1.521
1.00
19.98
A
C


ATOM
8064
NE
ARG
A
508
54.905
−27.288
0.346
1.00
21.98
A
N


ATOM
8066
CZ
ARG
A
508
54.787
−28.577
0.019
1.00
22.61
A
C


ATOM
8067
NH1
ARG
A
508
55.324
−29.538
0.767
1.00
22.88
A
N


ATOM
8070
NH2
ARG
A
508
54.120
−28.910
−1.080
1.00
22.72
A
N


ATOM
8073
C
ARG
A
508
54.783
−23.598
5.274
1.00
16.50
A
C


ATOM
8074
O
ARG
A
508
55.366
−23.724
6.347
1.00
16.45
A
O


ATOM
8076
N
GLN
A
509
54.634
−22.430
4.652
1.00
17.01
A
N


ATOM
8077
CA
GLN
A
509
55.139
−21.180
5.218
1.00
17.44
A
C


ATOM
8079
CB
GLN
A
509
54.932
−20.022
4.233
1.00
17.64
A
C


ATOM
8082
CG
GLN
A
509
55.378
−18.640
4.743
1.00
18.86
A
C


ATOM
8085
CD
GLN
A
509
56.866
−18.559
5.059
1.00
19.80
A
C


ATOM
8086
OE1
GLN
A
509
57.698
−19.142
4.364
1.00
21.40
A
O


ATOM
8087
NE2
GLN
A
509
57.205
−17.824
6.109
1.00
20.43
A
N


ATOM
8090
C
GLN
A
509
54.489
−20.856
6.566
1.00
17.62
A
C


ATOM
8091
O
GLN
A
509
55.147
−20.310
7.452
1.00
17.58
A
O


ATOM
8093
N
SER
A
510
53.208
−21.190
6.722
1.00
18.00
A
N


ATOM
8094
CA
SER
A
510
52.519
−20.976
7.995
1.00
18.54
A
C


ATOM
8096
CB
SER
A
510
51.036
−21.331
7.892
1.00
18.47
A
C


ATOM
8099
OG
SER
A
510
50.356
−20.392
7.083
1.00
18.50
A
O


ATOM
8101
C
SER
A
510
53.182
−21.778
9.109
1.00
19.15
A
C


ATOM
8102
O
SER
A
510
53.583
−21.212
10.124
1.00
19.12
A
O


ATOM
8104
N
HIS
A
511
53.307
−23.088
8.907
1.00
20.18
A
N


ATOM
8105
CA
HIS
A
511
54.032
−23.956
9.844
1.00
21.08
A
C


ATOM
8107
CB
HIS
A
511
54.180
−25.378
9.276
1.00
20.92
A
C


ATOM
8110
CG
HIS
A
511
52.976
−26.246
9.480
1.00
21.15
A
C


ATOM
8111
ND1
HIS
A
511
52.496
−26.574
10.731
1.00
23.07
A
N


ATOM
8113
CE1
HIS
A
511
51.438
−27.355
10.605
1.00
21.16
A
C


ATOM
8115
NE2
HIS
A
511
51.220
−27.555
9.318
1.00
20.02
A
N


ATOM
8117
CD2
HIS
A
511
52.171
−26.877
8.593
1.00
20.33
A
C


ATOM
8119
C
HIS
A
511
55.422
−23.394
10.176
1.00
22.01
A
C


ATOM
8120
O
HIS
A
511
55.836
−23.382
11.340
1.00
22.10
A
O


ATOM
8122
N
CYS
A
512
56.127
−22.928
9.145
1.00
22.75
A
N


ATOM
8123
CA
CYS
A
512
57.489
−22.410
9.291
1.00
23.31
A
C


ATOM
8125
CB
CYS
A
512
58.162
−22.308
7.918
1.00
23.29
A
C


ATOM
8128
SG
CYS
A
512
58.272
−23.878
7.018
1.00
23.12
A
S


ATOM
8130
C
CYS
A
512
57.560
−21.048
9.997
1.00
24.05
A
C


ATOM
8131
O
CYS
A
512
58.612
−20.683
10.522
1.00
24.32
A
O


ATOM
8133
N
THR
A
513
56.455
−20.303
10.006
1.00
24.74
A
N


ATOM
8134
CA
THR
A
513
56.424
−18.975
10.627
1.00
25.50
A
C


ATOM
8136
CB
THR
A
513
55.556
−17.982
9.806
1.00
25.40
A
C


ATOM
8138
OG1
THR
A
513
56.349
−17.410
8.760
1.00
24.78
A
O


ATOM
8140
CG2
THR
A
513
55.027
−16.856
10.681
1.00
25.88
A
C


ATOM
8144
C
THR
A
513
55.948
−19.012
12.082
1.00
26.41
A
C


ATOM
8145
O
THR
A
513
56.535
−18.347
12.940
1.00
26.85
A
O


ATOM
8147
N
TYR
A
514
54.899
−19.786
12.361
1.00
27.13
A
N


ATOM
8148
CA
TYR
A
514
54.304
−19.828
13.703
1.00
27.65
A
C


ATOM
8150
CB
TYR
A
514
52.780
−19.915
13.608
1.00
27.23
A
C


ATOM
8153
CG
TYR
A
514
52.205
−18.699
12.929
1.00
25.40
A
C


ATOM
8154
CD1
TYR
A
514
52.107
−17.486
13.607
1.00
24.39
A
C


ATOM
8156
CE1
TYR
A
514
51.598
−16.355
12.985
1.00
22.46
A
C


ATOM
8158
CZ
TYR
A
514
51.196
−16.428
11.667
1.00
21.99
A
C


ATOM
8159
OH
TYR
A
514
50.694
−15.313
11.041
1.00
21.78
A
O


ATOM
8161
CE2
TYR
A
514
51.297
−17.618
10.969
1.00
22.62
A
C


ATOM
8163
CD2
TYR
A
514
51.804
−18.743
11.600
1.00
22.78
A
C


ATOM
8165
C
TYR
A
514
54.883
−20.942
14.571
1.00
29.02
A
C


ATOM
8166
O
TYR
A
514
54.290
−22.013
14.724
1.00
28.90
A
O


ATOM
8168
N
HIS
A
515
56.057
−20.655
15.129
1.00
30.73
A
N


ATOM
8169
CA
HIS
A
515
56.761
−21.538
16.063
1.00
32.06
A
C


ATOM
8171
CB
HIS
A
515
58.121
−21.948
15.484
1.00
32.40
A
C


ATOM
8174
CG
HIS
A
515
59.036
−20.791
15.217
1.00
33.80
A
C


ATOM
8175
ND1
HIS
A
515
59.022
−20.090
14.030
1.00
34.76
A
N


ATOM
8177
CE1
HIS
A
515
59.920
−19.122
14.081
1.00
35.38
A
C


ATOM
8179
NE2
HIS
A
515
60.513
−19.166
15.261
1.00
35.75
A
N


ATOM
8181
CD2
HIS
A
515
59.977
−20.200
15.991
1.00
34.95
A
C


ATOM
8183
C
HIS
A
515
56.966
−20.796
17.389
1.00
32.51
A
C


ATOM
8184
O
HIS
A
515
56.694
−19.593
17.484
1.00
32.74
A
O


ATOM
8186
N
ASN
A
516
57.448
−21.517
18.401
1.00
32.73
A
N


ATOM
8187
CA
ASN
A
516
57.747
−20.931
19.713
1.00
32.96
A
C


ATOM
8189
CB
ASN
A
516
56.625
−21.237
20.715
1.00
33.20
A
C


ATOM
8192
CG
ASN
A
516
55.351
−20.436
20.446
1.00
33.85
A
C


ATOM
8193
OD1
ASN
A
516
54.596
−20.730
19.512
1.00
31.44
A
O


ATOM
8194
ND2
ASN
A
516
55.097
−19.430
21.283
1.00
33.00
A
N


ATOM
8197
C
ASN
A
516
59.081
−21.436
20.261
1.00
32.91
A
C


ATOM
8198
O
ASN
A
516
60.121
−21.308
19.611
1.00
33.04
A
O


ATOM
8200
N
THR
A
521
66.548
−21.132
21.796
1.00
40.70
A
N


ATOM
8201
CA
THR
A
521
66.207
−20.050
20.874
1.00
40.78
A
C


ATOM
8203
CB
THR
A
521
66.436
−20.476
19.406
1.00
40.62
A
C


ATOM
8205
OG1
THR
A
521
67.703
−21.134
19.285
1.00
39.94
A
O


ATOM
8207
CG2
THR
A
521
66.402
−19.267
18.478
1.00
40.21
A
C


ATOM
8211
C
THR
A
521
64.746
−19.619
21.056
1.00
41.19
A
C


ATOM
8212
O
THR
A
521
63.841
−20.460
21.049
1.00
41.68
A
O


ATOM
8214
N
SER
A
522
64.523
−18.313
21.209
1.00
41.01
A
N


ATOM
8215
CA
SER
A
522
63.182
−17.767
21.453
1.00
40.95
A
C


ATOM
8217
CB
SER
A
522
63.294
−16.355
22.049
1.00
40.91
A
C


ATOM
8220
OG
SER
A
522
63.552
−15.382
21.052
1.00
40.15
A
O


ATOM
8222
C
SER
A
522
62.329
−17.754
20.168
1.00
41.29
A
C


ATOM
8223
O
SER
A
522
62.835
−18.071
19.089
1.00
41.26
A
O


ATOM
8225
N
PRO
A
523
61.026
−17.409
20.282
1.00
41.67
A
N


ATOM
8226
CA
PRO
A
523
60.172
−17.283
19.088
1.00
41.68
A
C


ATOM
8228
CB
PRO
A
523
58.815
−16.856
19.666
1.00
41.63
A
C


ATOM
8231
CG
PRO
A
523
58.807
−17.408
21.044
1.00
41.77
A
C


ATOM
8234
CD
PRO
A
523
60.230
−17.359
21.526
1.00
41.83
A
C


ATOM
8237
C
PRO
A
523
60.679
−16.274
18.041
1.00
41.69
A
C


ATOM
8238
O
PRO
A
523
60.935
−16.665
16.900
1.00
41.96
A
O


ATOM
8239
N
ASP
A
524
60.820
−15.003
18.422
1.00
41.43
A
N


ATOM
8240
CA
ASP
A
524
61.364
−13.979
17.522
1.00
41.02
A
C


ATOM
8242
CB
ASP
A
524
60.602
−12.652
17.664
1.00
41.31
A
C


ATOM
8245
CG
ASP
A
524
60.708
−11.774
16.417
1.00
42.01
A
C


ATOM
8246
OD1
ASP
A
524
61.842
−11.469
15.989
1.00
42.29
A
O


ATOM
8247
OD2
ASP
A
524
59.655
−11.387
15.865
1.00
42.57
A
O


ATOM
8248
C
ASP
A
524
62.854
−13.803
17.824
1.00
40.28
A
C


ATOM
8249
O
ASP
A
524
63.228
−13.154
18.802
1.00
40.11
A
O


ATOM
8251
N
GLU
A
525
63.681
−14.371
16.946
1.00
39.60
A
N


ATOM
8252
CA
GLU
A
525
65.126
−14.597
17.159
1.00
39.35
A
C


ATOM
8254
CB
GLU
A
525
65.483
−14.783
18.645
1.00
39.51
A
C


ATOM
8257
CG
GLU
A
525
66.978
−14.944
18.955
1.00
40.12
A
C


ATOM
8260
CD
GLU
A
525
67.789
−13.676
18.721
1.00
41.52
A
C


ATOM
8261
OE1
GLU
A
525
69.013
−13.799
18.496
1.00
41.73
A
O


ATOM
8262
OE2
GLU
A
525
67.217
−12.562
18.760
1.00
41.99
A
O


ATOM
8263
C
GLU
A
525
65.554
−15.835
16.352
1.00
38.94
A
C


ATOM
8264
O
GLU
A
525
66.736
−15.994
16.020
1.00
39.49
A
O


ATOM
8266
N
LEU
A
526
64.589
−16.716
16.072
1.00
37.92
A
N


ATOM
8267
CA
LEU
A
526
64.740
−17.769
15.068
1.00
36.89
A
C


ATOM
8269
CB
LEU
A
526
64.024
−19.049
15.516
1.00
36.77
A
C


ATOM
8272
CG
LEU
A
526
64.013
−20.253
14.565
1.00
36.82
A
C


ATOM
8274
CD1
LEU
A
526
63.540
−21.504
15.302
1.00
35.24
A
C


ATOM
8278
CD2
LEU
A
526
65.382
−20.492
13.935
1.00
36.63
A
C


ATOM
8282
C
LEU
A
526
64.185
−17.262
13.735
1.00
36.23
A
C


ATOM
8283
O
LEU
A
526
64.661
−17.654
12.671
1.00
36.06
A
O


ATOM
8285
N
THR
A
527
63.177
−16.391
13.805
1.00
35.70
A
N


ATOM
8286
CA
THR
A
527
62.713
−15.630
12.643
1.00
35.26
A
C


ATOM
8288
CB
THR
A
527
61.469
−14.766
12.981
1.00
35.09
A
C


ATOM
8290
OG1
THR
A
527
60.448
−15.587
13.560
1.00
35.42
A
O


ATOM
8292
CG2
THR
A
527
60.918
−14.084
11.730
1.00
33.75
A
C


ATOM
8296
C
THR
A
527
63.817
−14.705
12.121
1.00
35.05
A
C


ATOM
8297
O
THR
A
527
63.915
−14.473
10.914
1.00
35.33
A
O


ATOM
8299
N
ARG
A
528
64.645
−14.185
13.029
1.00
34.45
A
N


ATOM
8300
CA
ARG
A
528
65.746
−13.295
12.654
1.00
34.07
A
C


ATOM
8302
CB
ARG
A
528
66.399
−12.684
13.897
1.00
34.21
A
C


ATOM
8305
CG
ARG
A
528
67.430
−11.597
13.577
1.00
35.79
A
C


ATOM
8308
CD
ARG
A
528
68.237
−11.153
14.802
1.00
37.39
A
C


ATOM
8311
NE
ARG
A
528
68.738
−12.271
15.607
1.00
38.17
A
N


ATOM
8313
CZ
ARG
A
528
69.715
−13.105
15.245
1.00
37.53
A
C


ATOM
8314
NH1
ARG
A
528
70.333
−12.981
14.072
1.00
36.61
A
N


ATOM
8317
NH2
ARG
A
528
70.079
−14.085
16.066
1.00
37.93
A
N


ATOM
8320
C
ARG
A
528
66.801
−14.024
11.819
1.00
33.31
A
C


ATOM
8321
O
ARG
A
528
67.225
−13.525
10.774
1.00
33.25
A
O


ATOM
8323
N
LYS
A
529
67.221
−15.198
12.287
1.00
32.35
A
N


ATOM
8324
CA
LYS
A
529
68.219
−16.003
11.579
1.00
31.60
A
C


ATOM
8326
CB
LYS
A
529
68.676
−17.186
12.439
1.00
31.66
A
C


ATOM
8329
CG
LYS
A
529
69.437
−16.800
13.696
1.00
31.41
A
C


ATOM
8332
CD
LYS
A
529
69.959
−18.035
14.408
1.00
31.32
A
C


ATOM
8335
CE
LYS
A
529
70.798
−17.669
15.617
1.00
32.31
A
C


ATOM
8338
NZ
LYS
A
529
71.369
−18.876
16.276
1.00
33.65
A
N


ATOM
8342
C
LYS
A
529
67.670
−16.531
10.260
1.00
30.95
A
C


ATOM
8343
O
LYS
A
529
68.297
−16.364
9.213
1.00
30.56
A
O


ATOM
8345
N
ARG
A
530
66.501
−17.170
10.329
1.00
30.64
A
N


ATOM
8346
CA
ARG
A
530
65.846
−17.760
9.153
1.00
30.15
A
C


ATOM
8348
CB
ARG
A
530
64.482
−18.362
9.525
1.00
29.94
A
C


ATOM
8351
CG
ARG
A
530
64.561
−19.726
10.225
1.00
29.01
A
C


ATOM
8354
CD
ARG
A
530
63.171
−20.281
10.550
1.00
27.64
A
C


ATOM
8357
NE
ARG
A
530
63.220
−21.609
11.172
1.00
25.77
A
N


ATOM
8359
CZ
ARG
A
530
62.150
−22.322
11.537
1.00
23.97
A
C


ATOM
8360
NH1
ARG
A
530
60.921
−21.851
11.352
1.00
22.79
A
N


ATOM
8363
NH2
ARG
A
530
62.307
−23.518
12.092
1.00
23.31
A
N


ATOM
8366
C
ARG
A
530
65.689
−16.746
8.017
1.00
30.16
A
C


ATOM
8367
O
ARG
A
530
65.923
−17.075
6.853
1.00
30.17
A
O


ATOM
8369
N
VAL
A
531
65.304
−15.518
8.360
1.00
30.09
A
N


ATOM
8370
CA
VAL
A
531
65.249
−14.423
7.384
1.00
29.85
A
C


ATOM
8372
CB
VAL
A
531
64.687
−13.116
8.009
1.00
29.92
A
C


ATOM
8374
CG1
VAL
A
531
65.130
−11.891
7.212
1.00
29.47
A
C


ATOM
8378
CG2
VAL
A
531
63.166
−13.183
8.090
1.00
30.50
A
C


ATOM
8382
C
VAL
A
531
66.628
−14.151
6.781
1.00
29.24
A
C


ATOM
8383
O
VAL
A
531
66.781
−14.158
5.559
1.00
29.23
A
O


ATOM
8385
N
LEU
A
532
67.623
−13.925
7.639
1.00
28.50
A
N


ATOM
8386
CA
LEU
A
532
68.994
−13.652
7.186
1.00
28.01
A
C


ATOM
8388
CB
LEU
A
532
69.944
−13.450
8.378
1.00
28.09
A
C


ATOM
8391
CG
LEU
A
532
70.095
−12.013
8.894
1.00
28.78
A
C


ATOM
8393
CD1
LEU
A
532
68.741
−11.373
9.211
1.00
28.04
A
C


ATOM
8397
CD2
LEU
A
532
71.014
−11.979
10.112
1.00
28.59
A
C


ATOM
8401
C
LEU
A
532
69.533
−14.754
6.272
1.00
27.20
A
C


ATOM
8402
O
LEU
A
532
70.151
−14.470
5.243
1.00
26.80
A
O


ATOM
8404
N
SER
A
533
69.283
−16.004
6.652
1.00
26.36
A
N


ATOM
8405
CA
SER
A
533
69.742
−17.159
5.883
1.00
25.65
A
C


ATOM
8407
CB
SER
A
533
69.573
−18.437
6.705
1.00
25.79
A
C


ATOM
8410
OG
SER
A
533
68.231
−18.588
7.127
1.00
26.13
A
O


ATOM
8412
C
SER
A
533
69.009
−17.306
4.549
1.00
24.80
A
C


ATOM
8413
O
SER
A
533
69.589
−17.786
3.573
1.00
24.87
A
O


ATOM
8415
N
VAL
A
534
67.742
−16.897
4.514
1.00
23.73
A
N


ATOM
8416
CA
VAL
A
534
66.930
−16.993
3.299
1.00
22.78
A
C


ATOM
8418
CB
VAL
A
534
65.442
−17.279
3.634
1.00
22.62
A
C


ATOM
8420
CG1
VAL
A
534
64.574
−17.176
2.393
1.00
22.83
A
C


ATOM
8424
CG2
VAL
A
534
65.299
−18.661
4.247
1.00
20.75
A
C


ATOM
8428
C
VAL
A
534
67.063
−15.751
2.407
1.00
22.04
A
C


ATOM
8429
O
VAL
A
534
67.186
−15.880
1.188
1.00
21.64
A
O


ATOM
8431
N
ILE
A
535
67.058
−14.562
3.010
1.00
21.46
A
N


ATOM
8432
CA
ILE
A
535
67.090
−13.304
2.249
1.00
21.12
A
C


ATOM
8434
CB
ILE
A
535
66.130
−12.241
2.845
1.00
21.03
A
C


ATOM
8436
CG1
ILE
A
535
64.702
−12.782
2.954
1.00
19.56
A
C


ATOM
8439
CD1
ILE
A
535
64.055
−13.076
1.628
1.00
18.99
A
C


ATOM
8443
CG2
ILE
A
535
66.138
−10.979
1.990
1.00
20.45
A
C


ATOM
8447
C
ILE
A
535
68.488
−12.678
2.122
1.00
21.08
A
C


ATOM
8448
O
ILE
A
535
69.043
−12.638
1.025
1.00
21.16
A
O


ATOM
8450
N
THR
A
536
69.049
−12.188
3.229
1.00
21.05
A
N


ATOM
8451
CA
THR
A
536
70.220
−11.290
3.167
1.00
21.47
A
C


ATOM
8453
CB
THR
A
536
70.259
−10.315
4.373
1.00
21.61
A
C


ATOM
8455
OG1
THR
A
536
70.381
−11.053
5.593
1.00
23.10
A
O


ATOM
8457
CG2
THR
A
536
68.993
−9.465
4.422
1.00
22.21
A
C


ATOM
8461
C
THR
A
536
71.587
−11.983
3.039
1.00
20.97
A
C


ATOM
8462
O
THR
A
536
72.308
−11.747
2.069
1.00
20.73
A
O


ATOM
8464
N
GLU
A
537
71.947
−12.817
4.013
1.00
20.65
A
N


ATOM
8465
CA
GLU
A
537
73.259
−13.474
4.017
1.00
20.51
A
C


ATOM
8467
CB
GLU
A
537
73.649
−13.911
5.432
1.00
20.64
A
C


ATOM
8470
CG
GLU
A
537
73.824
−12.751
6.409
1.00
21.25
A
C


ATOM
8473
CD
GLU
A
537
74.728
−13.076
7.590
1.00
20.98
A
C


ATOM
8474
OE1
GLU
A
537
74.910
−12.186
8.448
1.00
19.76
A
O


ATOM
8475
OE2
GLU
A
537
75.261
−14.205
7.663
1.00
20.90
A
O


ATOM
8476
C
GLU
A
537
73.294
−14.689
3.088
1.00
20.36
A
C


ATOM
8477
O
GLU
A
537
72.475
−15.599
3.235
1.00
20.54
A
O


ATOM
8479
N
PRO
A
538
74.244
−14.718
2.130
1.00
20.10
A
N


ATOM
8480
CA
PRO
A
538
74.398
−15.928
1.321
1.00
19.67
A
C


ATOM
8482
CB
PRO
A
538
75.354
−15.495
0.198
1.00
19.39
A
C


ATOM
8485
CG
PRO
A
538
75.435
−14.010
0.274
1.00
19.88
A
C


ATOM
8488
CD
PRO
A
538
75.155
−13.647
1.688
1.00
20.22
A
C


ATOM
8491
C
PRO
A
538
75.009
−17.071
2.123
1.00
19.62
A
C


ATOM
8492
O
PRO
A
538
75.449
−16.868
3.256
1.00
19.61
A
O


ATOM
8493
N
ILE
A
539
75.027
−18.263
1.534
1.00
19.52
A
N


ATOM
8494
CA
ILE
A
539
75.661
−19.422
2.154
1.00
19.35
A
C


ATOM
8496
CB
ILE
A
539
75.149
−20.739
1.535
1.00
19.15
A
C


ATOM
8498
CG1
ILE
A
539
73.656
−20.902
1.813
1.00
19.17
A
C


ATOM
8501
CD1
ILE
A
539
73.079
−22.205
1.311
1.00
19.79
A
C


ATOM
8505
CG2
ILE
A
539
75.913
−21.934
2.090
1.00
19.34
A
C


ATOM
8509
C
ILE
A
539
77.173
−19.326
1.977
1.00
19.38
A
C


ATOM
8510
O
ILE
A
539
77.652
−18.812
0.963
1.00
18.71
A
O


ATOM
8512
N
LEU
A
540
77.920
−19.810
2.969
1.00
19.89
A
N


ATOM
8513
CA
LEU
A
540
79.379
−19.852
2.876
1.00
20.47
A
C


ATOM
8515
CB
LEU
A
540
80.001
−20.467
4.139
1.00
20.46
A
C


ATOM
8518
CG
LEU
A
540
79.948
−19.634
5.427
1.00
20.08
A
C


ATOM
8520
CD1
LEU
A
540
80.419
−20.457
6.618
1.00
18.44
A
C


ATOM
8524
CD2
LEU
A
540
80.775
−18.359
5.296
1.00
17.67
A
C


ATOM
8528
C
LEU
A
540
79.765
−20.664
1.638
1.00
20.82
A
C


ATOM
8529
O
LEU
A
540
79.241
−21.761
1.438
1.00
20.93
A
O


ATOM
8531
N
PRO
A
541
80.669
−20.123
0.797
1.00
21.10
A
N


ATOM
8532
CA
PRO
A
541
80.960
−20.737
−0.501
1.00
21.17
A
C


ATOM
8534
CB
PRO
A
541
81.831
−19.687
−1.197
1.00
20.94
A
C


ATOM
8537
CG
PRO
A
541
82.477
−18.951
−0.096
1.00
21.31
A
C


ATOM
8540
CD
PRO
A
541
81.484
−18.917
1.024
1.00
21.15
A
C


ATOM
8543
C
PRO
A
541
81.692
−22.071
−0.401
1.00
21.47
A
C


ATOM
8544
O
PRO
A
541
82.045
−22.508
0.693
1.00
21.43
A
O


ATOM
8545
N
PHE
A
542
81.915
−22.701
−1.550
1.00
22.16
A
N


ATOM
8546
CA
PHE
A
542
82.488
−24.043
−1.607
1.00
22.83
A
C


ATOM
8548
CB
PHE
A
542
82.148
−24.685
−2.953
1.00
22.75
A
C


ATOM
8551
CG
PHE
A
542
82.651
−26.095
−3.102
1.00
22.87
A
C


ATOM
8552
CD1
PHE
A
542
83.477
−26.446
−4.163
1.00
22.56
A
C


ATOM
8554
CE1
PHE
A
542
83.938
−27.747
−4.306
1.00
21.48
A
C


ATOM
8556
CZ
PHE
A
542
83.581
−28.712
−3.382
1.00
21.47
A
C


ATOM
8558
CE2
PHE
A
542
82.760
−28.376
−2.316
1.00
22.09
A
C


ATOM
8560
CD2
PHE
A
542
82.301
−27.073
−2.180
1.00
22.60
A
C


ATOM
8562
C
PHE
A
542
84.007
−24.066
−1.386
1.00
23.60
A
C


ATOM
8563
O
PHE
A
542
84.750
−23.309
−2.017
1.00
23.24
A
O


ATOM
8565
N
GLU
A
543
84.447
−24.940
−0.480
1.00
24.65
A
N


ATOM
8566
CA
GLU
A
543
85.867
−25.238
−0.264
1.00
25.63
A
C


ATOM
8568
CB
GLU
A
543
86.242
−25.032
1.209
1.00
25.64
A
C


ATOM
8571
CG
GLU
A
543
86.531
−23.587
1.593
1.00
25.04
A
C


ATOM
8574
CD
GLU
A
543
87.219
−23.462
2.945
1.00
24.31
A
C


ATOM
8575
OE1
GLU
A
543
87.195
−24.433
3.733
1.00
23.03
A
O


ATOM
8576
OE2
GLU
A
543
87.787
−22.385
3.219
1.00
23.80
A
O


ATOM
8577
C
GLU
A
543
86.149
−26.685
−0.685
1.00
26.60
A
C


ATOM
8578
O
GLU
A
543
85.244
−27.387
−1.132
1.00
26.93
A
O


ATOM
8580
N
ARG
A
544
87.398
−27.128
−0.543
1.00
27.49
A
N


ATOM
8581
CA
ARG
A
544
87.790
−28.496
−0.904
1.00
28.18
A
C


ATOM
8583
CB
ARG
A
544
88.462
−28.503
−2.283
1.00
28.70
A
C


ATOM
8586
CG
ARG
A
544
87.480
−28.538
−3.454
1.00
30.13
A
C


ATOM
8589
CD
ARG
A
544
87.958
−27.689
−4.627
1.00
32.27
A
C


ATOM
8592
NE
ARG
A
544
87.029
−27.745
−5.758
1.00
34.04
A
N


ATOM
8594
CZ
ARG
A
544
86.969
−26.853
−6.749
1.00
35.15
A
C


ATOM
8595
NH1
ARG
A
544
87.785
−25.801
−6.780
1.00
35.93
A
N


ATOM
8598
NH2
ARG
A
544
86.078
−27.010
−7.722
1.00
35.60
A
N


ATOM
8601
C
ARG
A
544
88.718
−29.113
0.148
1.00
28.07
A
C


ATOM
8602
O
ARG
A
544
89.936
−28.927
0.113
1.00
27.79
A
O


ATOM
8604
N
SER
B
6
65.194
37.534
11.490
1.00
30.93
B
N


ATOM
8605
CA
SER
B
6
66.501
38.213
11.258
1.00
31.10
B
C


ATOM
8607
CB
SER
B
6
67.126
38.622
12.599
1.00
31.12
B
C


ATOM
8610
OG
SER
B
6
68.384
39.251
12.418
1.00
30.48
B
O


ATOM
8612
C
SER
B
6
67.433
37.305
10.437
1.00
31.29
B
C


ATOM
8613
O
SER
B
6
67.056
36.867
9.347
1.00
31.44
B
O


ATOM
8617
N
ALA
B
7
68.634
37.031
10.954
1.00
31.29
B
N


ATOM
8618
CA
ALA
B
7
69.633
36.190
10.276
1.00
31.27
B
C


ATOM
8620
CB
ALA
B
7
70.875
36.063
11.153
1.00
31.07
B
C


ATOM
8624
C
ALA
B
7
69.128
34.792
9.894
1.00
31.29
B
C


ATOM
8625
O
ALA
B
7
68.262
34.227
10.566
1.00
31.47
B
O


ATOM
8627
N
ASN
B
8
69.690
34.242
8.817
1.00
31.13
B
N


ATOM
8628
CA
ASN
B
8
69.342
32.903
8.333
1.00
30.87
B
C


ATOM
8630
CB
ASN
B
8
68.536
33.009
7.033
1.00
30.78
B
C


ATOM
8633
CG
ASN
B
8
68.152
31.652
6.460
1.00
30.33
B
C


ATOM
8634
OD1
ASN
B
8
67.997
30.671
7.187
1.00
30.31
B
O


ATOM
8635
ND2
ASN
B
8
67.988
31.597
5.144
1.00
29.92
B
N


ATOM
8638
C
ASN
B
8
70.591
32.048
8.110
1.00
30.77
B
C


ATOM
8639
O
ASN
B
8
71.467
32.411
7.324
1.00
30.68
B
O


ATOM
8641
N
TYR
B
9
70.659
30.915
8.808
1.00
30.85
B
N


ATOM
8642
CA
TYR
B
9
71.782
29.980
8.700
1.00
30.90
B
C


ATOM
8644
CB
TYR
B
9
72.394
29.745
10.081
1.00
30.91
B
C


ATOM
8647
CG
TYR
B
9
72.941
30.996
10.724
1.00
31.38
B
C


ATOM
8648
CD1
TYR
B
9
74.066
31.627
10.207
1.00
31.49
B
C


ATOM
8650
CE1
TYR
B
9
74.577
32.772
10.792
1.00
31.53
B
C


ATOM
8652
CZ
TYR
B
9
73.963
33.302
11.915
1.00
31.18
B
C


ATOM
8653
OH
TYR
B
9
74.464
34.440
12.505
1.00
31.64
B
O


ATOM
8655
CE2
TYR
B
9
72.845
32.694
12.449
1.00
30.98
B
C


ATOM
8657
CD2
TYR
B
9
72.340
31.545
11.853
1.00
31.50
B
C


ATOM
8659
C
TYR
B
9
71.392
28.628
8.099
1.00
30.89
B
C


ATOM
8660
O
TYR
B
9
72.244
27.749
7.954
1.00
30.84
B
O


ATOM
8662
N
GLU
B
10
70.118
28.461
7.748
1.00
30.91
B
N


ATOM
8663
CA
GLU
B
10
69.619
27.177
7.254
1.00
30.96
B
C


ATOM
8665
CB
GLU
B
10
68.090
27.193
7.135
1.00
31.16
B
C


ATOM
8668
CG
GLU
B
10
67.357
27.168
8.477
1.00
32.67
B
C


ATOM
8671
CD
GLU
B
10
65.997
26.478
8.404
1.00
34.80
B
C


ATOM
8672
OE1
GLU
B
10
65.359
26.497
7.327
1.00
35.78
B
O


ATOM
8673
OE2
GLU
B
10
65.564
25.914
9.433
1.00
34.93
B
O


ATOM
8674
C
GLU
B
10
70.237
26.801
5.905
1.00
30.57
B
C


ATOM
8675
O
GLU
B
10
70.673
27.678
5.156
1.00
30.27
B
O


ATOM
8677
N
PRO
B
11
70.281
25.490
5.596
1.00
30.23
B
N


ATOM
8678
CA
PRO
B
11
70.814
25.038
4.314
1.00
29.93
B
C


ATOM
8680
CB
PRO
B
11
70.985
23.528
4.519
1.00
29.85
B
C


ATOM
8683
CG
PRO
B
11
69.977
23.171
5.533
1.00
29.86
B
C


ATOM
8686
CD
PRO
B
11
69.874
24.357
6.448
1.00
30.23
B
C


ATOM
8689
C
PRO
B
11
69.862
25.312
3.154
1.00
29.66
B
C


ATOM
8690
O
PRO
B
11
68.641
25.250
3.325
1.00
29.68
B
O


ATOM
8691
N
ASN
B
12
70.428
25.631
1.993
1.00
29.25
B
N


ATOM
8692
CA
ASN
B
12
69.672
25.660
0.747
1.00
28.94
B
C


ATOM
8694
CB
ASN
B
12
70.298
26.638
−0.252
1.00
29.10
B
C


ATOM
8697
CG
ASN
B
12
70.210
28.086
0.208
1.00
29.53
B
C


ATOM
8698
OD1
ASN
B
12
69.136
28.575
0.559
1.00
31.39
B
O


ATOM
8699
ND2
ASN
B
12
71.342
28.782
0.196
1.00
28.62
B
N


ATOM
8702
C
ASN
B
12
69.646
24.253
0.162
1.00
28.62
B
C


ATOM
8703
O
ASN
B
12
70.554
23.458
0.409
1.00
28.75
B
O


ATOM
8705
N
SER
B
13
68.600
23.943
−0.600
1.00
28.28
B
N


ATOM
8706
CA
SER
B
13
68.467
22.629
−1.238
1.00
27.84
B
C


ATOM
8708
CB
SER
B
13
67.066
22.466
−1.842
1.00
27.87
B
C


ATOM
8711
OG
SER
B
13
66.698
23.594
−2.621
1.00
27.68
B
O


ATOM
8713
C
SER
B
13
69.540
22.403
−2.312
1.00
27.33
B
C


ATOM
8714
O
SER
B
13
69.999
21.280
−2.514
1.00
27.15
B
O


ATOM
8716
N
TRP
B
14
69.941
23.480
−2.982
1.00
26.98
B
N


ATOM
8717
CA
TRP
B
14
70.947
23.410
−4.047
1.00
27.01
B
C


ATOM
8719
CB
TRP
B
14
70.801
24.595
−5.025
1.00
27.03
B
C


ATOM
8722
CG
TRP
B
14
70.521
25.947
−4.396
1.00
27.01
B
C


ATOM
8723
CD1
TRP
B
14
69.295
26.521
−4.199
1.00
27.14
B
C


ATOM
8725
NE1
TRP
B
14
69.435
27.754
−3.612
1.00
26.54
B
N


ATOM
8727
CE2
TRP
B
14
70.768
28.009
−3.426
1.00
27.41
B
C


ATOM
8728
CD2
TRP
B
14
71.485
26.892
−3.911
1.00
27.68
B
C


ATOM
8729
CE3
TRP
B
14
72.884
26.902
−3.834
1.00
29.36
B
C


ATOM
8731
CZ3
TRP
B
14
73.516
28.014
−3.281
1.00
30.23
B
C


ATOM
8733
CH2
TRP
B
14
72.773
29.109
−2.808
1.00
29.91
B
C


ATOM
8735
CZ2
TRP
B
14
71.402
29.125
−2.873
1.00
28.79
B
C


ATOM
8737
C
TRP
B
14
72.402
23.306
−3.548
1.00
27.02
B
C


ATOM
8738
O
TRP
B
14
73.290
22.935
−4.320
1.00
26.74
B
O


ATOM
8740
N
ASP
B
15
72.638
23.614
−2.270
1.00
26.93
B
N


ATOM
8741
CA
ASP
B
15
73.999
23.688
−1.705
1.00
26.86
B
C


ATOM
8743
CB
ASP
B
15
73.944
23.887
−0.182
1.00
26.86
B
C


ATOM
8746
CG
ASP
B
15
73.721
25.336
0.219
1.00
26.99
B
C


ATOM
8747
OD1
ASP
B
15
73.870
26.238
−0.637
1.00
24.43
B
O


ATOM
8748
OD2
ASP
B
15
73.406
25.571
1.408
1.00
27.44
B
O


ATOM
8749
C
ASP
B
15
74.894
22.484
−2.010
1.00
26.90
B
C


ATOM
8750
O
ASP
B
15
74.415
21.365
−2.191
1.00
26.83
B
O


ATOM
8752
N
TYR
B
16
76.202
22.739
−2.039
1.00
27.18
B
N


ATOM
8753
CA
TYR
B
16
77.202
21.717
−2.361
1.00
27.47
B
C


ATOM
8755
CB
TYR
B
16
78.530
22.369
−2.767
1.00
27.32
B
C


ATOM
8758
CG
TYR
B
16
78.492
23.077
−4.106
1.00
25.78
B
C


ATOM
8759
CD1
TYR
B
16
78.255
22.372
−5.283
1.00
24.46
B
C


ATOM
8761
CE1
TYR
B
16
78.223
23.015
−6.512
1.00
23.58
B
C


ATOM
8763
CZ
TYR
B
16
78.436
24.378
−6.576
1.00
23.84
B
C


ATOM
8764
OH
TYR
B
16
78.405
25.020
−7.792
1.00
23.45
B
O


ATOM
8766
CE2
TYR
B
16
78.679
25.100
−5.422
1.00
24.10
B
C


ATOM
8768
CD2
TYR
B
16
78.707
24.446
−4.197
1.00
24.90
B
C


ATOM
8770
C
TYR
B
16
77.449
20.724
−1.219
1.00
28.17
B
C


ATOM
8771
O
TYR
B
16
77.971
19.635
−1.455
1.00
28.00
B
O


ATOM
8773
N
ASP
B
17
77.100
21.103
0.009
1.00
28.94
B
N


ATOM
8774
CA
ASP
B
17
77.182
20.189
1.153
1.00
29.33
B
C


ATOM
8776
CB
ASP
B
17
77.135
20.960
2.479
1.00
29.08
B
C


ATOM
8779
CG
ASP
B
17
78.279
21.954
2.627
1.00
28.02
B
C


ATOM
8780
OD1
ASP
B
17
78.883
22.334
1.602
1.00
26.84
B
O


ATOM
8781
OD2
ASP
B
17
78.570
22.364
3.770
1.00
26.76
B
O


ATOM
8782
C
ASP
B
17
76.026
19.188
1.087
1.00
30.23
B
C


ATOM
8783
O
ASP
B
17
76.202
17.997
1.355
1.00
30.34
B
O


ATOM
8785
N
TYR
B
18
74.847
19.697
0.728
1.00
31.12
B
N


ATOM
8786
CA
TYR
B
18
73.640
18.888
0.552
1.00
32.00
B
C


ATOM
8788
CB
TYR
B
18
72.432
19.814
0.349
1.00
32.50
B
C


ATOM
8791
CG
TYR
B
18
71.072
19.146
0.372
1.00
34.76
B
C


ATOM
8792
CD1
TYR
B
18
70.211
19.321
1.455
1.00
37.40
B
C


ATOM
8794
CE1
TYR
B
18
68.955
18.727
1.479
1.00
38.40
B
C


ATOM
8796
CZ
TYR
B
18
68.545
17.952
0.408
1.00
38.58
B
C


ATOM
8797
OH
TYR
B
18
67.302
17.361
0.428
1.00
39.64
B
O


ATOM
8799
CE2
TYR
B
18
69.378
17.770
−0.683
1.00
37.47
B
C


ATOM
8801
CD2
TYR
B
18
70.631
18.369
−0.698
1.00
35.94
B
C


ATOM
8803
C
TYR
B
18
73.821
17.938
−0.634
1.00
32.06
B
C


ATOM
8804
O
TYR
B
18
73.879
16.722
−0.447
1.00
32.28
B
O


ATOM
8806
N
LEU
B
19
73.916
18.495
−1.844
1.00
31.97
B
N


ATOM
8807
CA
LEU
B
19
74.291
17.725
−3.033
1.00
31.81
B
C


ATOM
8809
CB
LEU
B
19
74.101
18.552
−4.310
1.00
31.61
B
C


ATOM
8812
CG
LEU
B
19
72.673
18.884
−4.747
1.00
31.60
B
C


ATOM
8814
CD1
LEU
B
19
72.676
20.011
−5.771
1.00
29.70
B
C


ATOM
8818
CD2
LEU
B
19
71.975
17.650
−5.307
1.00
32.90
B
C


ATOM
8822
C
LEU
B
19
75.755
17.334
−2.900
1.00
32.11
B
C


ATOM
8823
O
LEU
B
19
76.478
17.920
−2.100
1.00
32.07
B
O


ATOM
8825
N
LEU
B
20
76.188
16.346
−3.679
1.00
32.38
B
N


ATOM
8826
CA
LEU
B
20
77.580
15.881
−3.655
1.00
32.60
B
C


ATOM
8828
CB
LEU
B
20
78.543
17.016
−4.048
1.00
32.67
B
C


ATOM
8831
CG
LEU
B
20
78.184
17.857
−5.275
1.00
32.36
B
C


ATOM
8833
CD1
LEU
B
20
79.247
18.915
−5.510
1.00
31.31
B
C


ATOM
8837
CD2
LEU
B
20
78.023
16.976
−6.502
1.00
32.73
B
C


ATOM
8841
C
LEU
B
20
77.976
15.298
−2.289
1.00
32.78
B
C


ATOM
8842
O
LEU
B
20
78.727
15.917
−1.531
1.00
32.45
B
O


ATOM
8844
N
SER
B
21
77.462
14.108
−1.984
1.00
33.27
B
N


ATOM
8845
CA
SER
B
21
77.803
13.407
−0.740
1.00
33.68
B
C


ATOM
8847
CB
SER
B
21
76.696
13.592
0.307
1.00
33.73
B
C


ATOM
8850
OG
SER
B
21
75.453
13.090
−0.153
1.00
33.56
B
O


ATOM
8852
C
SER
B
21
78.067
11.916
−0.981
1.00
33.90
B
C


ATOM
8853
O
SER
B
21
77.611
11.344
−1.976
1.00
33.89
B
O


ATOM
8855
N
SER
B
22
78.813
11.303
−0.063
1.00
34.06
B
N


ATOM
8856
CA
SER
B
22
79.177
9.888
−0.163
1.00
34.19
B
C


ATOM
8858
CB
SER
B
22
80.431
9.720
−1.026
1.00
34.22
B
C


ATOM
8861
OG
SER
B
22
81.500
10.512
−0.537
1.00
34.16
B
O


ATOM
8863
C
SER
B
22
79.417
9.282
1.218
1.00
34.24
B
C


ATOM
8864
O
SER
B
22
78.552
8.598
1.766
1.00
34.40
B
O


ATOM
8866
N
ILE
B
28
83.096
12.126
−5.219
1.00
33.03
B
N


ATOM
8867
CA
ILE
B
28
82.293
13.341
−5.130
1.00
33.17
B
C


ATOM
8869
CB
ILE
B
28
80.768
13.019
−5.067
1.00
33.49
B
C


ATOM
8871
CG1
ILE
B
28
80.431
11.736
−5.840
1.00
33.77
B
C


ATOM
8874
CD1
ILE
B
28
78.942
11.415
−5.876
1.00
33.05
B
C


ATOM
8878
CG2
ILE
B
28
79.953
14.191
−5.610
1.00
33.81
B
C


ATOM
8882
C
ILE
B
28
82.693
14.165
−3.897
1.00
33.01
B
C


ATOM
8883
O
ILE
B
28
81.856
14.845
−3.299
1.00
33.03
B
O


ATOM
8885
N
GLU
B
29
83.977
14.116
−3.537
1.00
32.83
B
N


ATOM
8886
CA
GLU
B
29
84.462
14.714
−2.288
1.00
32.67
B
C


ATOM
8888
CB
GLU
B
29
85.136
13.647
−1.429
1.00
32.76
B
C


ATOM
8891
CG
GLU
B
29
84.198
12.510
−1.051
1.00
33.72
B
C


ATOM
8894
CD
GLU
B
29
84.786
11.574
−0.012
1.00
35.62
B
C


ATOM
8895
OE1
GLU
B
29
85.447
12.061
0.932
1.00
37.99
B
O


ATOM
8896
OE2
GLU
B
29
84.579
10.348
−0.136
1.00
35.42
B
O


ATOM
8897
C
GLU
B
29
85.407
15.895
−2.516
1.00
32.29
B
C


ATOM
8898
O
GLU
B
29
85.093
17.019
−2.125
1.00
32.51
B
O


ATOM
8900
N
VAL
B
30
86.559
15.650
−3.138
1.00
31.62
B
N


ATOM
8901
CA
VAL
B
30
87.465
16.741
−3.525
1.00
30.85
B
C


ATOM
8903
CB
VAL
B
30
88.830
16.207
−4.027
1.00
30.72
B
C


ATOM
8905
CG1
VAL
B
30
89.708
17.345
−4.528
1.00
30.15
B
C


ATOM
8909
CG2
VAL
B
30
89.538
15.439
−2.917
1.00
30.01
B
C


ATOM
8913
C
VAL
B
30
86.787
17.605
−4.600
1.00
30.37
B
C


ATOM
8914
O
VAL
B
30
87.082
18.791
−4.739
1.00
30.28
B
O


ATOM
8916
N
TYR
B
31
85.877
16.984
−5.346
1.00
29.78
B
N


ATOM
8917
CA
TYR
B
31
84.969
17.674
−6.262
1.00
29.51
B
C


ATOM
8919
CB
TYR
B
31
84.111
16.625
−6.984
1.00
29.72
B
C


ATOM
8922
CG
TYR
B
31
83.435
17.063
−8.268
1.00
30.61
B
C


ATOM
8923
CD1
TYR
B
31
84.175
17.308
−9.424
1.00
30.75
B
C


ATOM
8925
CE1
TYR
B
31
83.548
17.683
−10.614
1.00
31.57
B
C


ATOM
8927
CZ
TYR
B
31
82.163
17.800
−10.655
1.00
31.88
B
C


ATOM
8928
OH
TYR
B
31
81.530
18.173
−11.822
1.00
30.54
B
O


ATOM
8930
CE2
TYR
B
31
81.409
17.546
−9.524
1.00
31.66
B
C


ATOM
8932
CD2
TYR
B
31
82.045
17.173
−8.342
1.00
32.07
B
C


ATOM
8934
C
TYR
B
31
84.076
18.654
−5.490
1.00
28.96
B
C


ATOM
8935
O
TYR
B
31
83.852
19.780
−5.933
1.00
29.21
B
O


ATOM
8937
N
LYS
B
32
83.574
18.211
−4.336
1.00
28.11
B
N


ATOM
8938
CA
LYS
B
32
82.742
19.037
−3.446
1.00
27.18
B
C


ATOM
8940
CB
LYS
B
32
82.091
18.152
−2.368
1.00
27.40
B
C


ATOM
8943
CG
LYS
B
32
81.289
18.888
−1.291
1.00
27.70
B
C


ATOM
8946
CD
LYS
B
32
81.011
17.982
−0.088
1.00
28.13
B
C


ATOM
8949
CE
LYS
B
32
82.214
17.904
0.859
1.00
27.91
B
C


ATOM
8952
NZ
LYS
B
32
82.132
16.766
1.823
1.00
26.03
B
N


ATOM
8956
C
LYS
B
32
83.549
20.159
−2.788
1.00
26.03
B
C


ATOM
8957
O
LYS
B
32
83.099
21.305
−2.740
1.00
25.99
B
O


ATOM
8959
N
ASP
B
33
84.731
19.820
−2.274
1.00
24.80
B
N


ATOM
8960
CA
ASP
B
33
85.635
20.807
−1.666
1.00
23.80
B
C


ATOM
8962
CB
ASP
B
33
86.882
20.123
−1.073
1.00
23.97
B
C


ATOM
8965
CG
ASP
B
33
86.603
19.412
0.252
1.00
23.84
B
C


ATOM
8966
OD1
ASP
B
33
85.444
19.021
0.506
1.00
24.89
B
O


ATOM
8967
OD2
ASP
B
33
87.557
19.238
1.041
1.00
21.93
B
O


ATOM
8968
C
ASP
B
33
86.074
21.887
−2.664
1.00
22.53
B
C


ATOM
8969
O
ASP
B
33
86.377
23.012
−2.270
1.00
22.50
B
O


ATOM
8971
N
LYS
B
34
86.111
21.537
−3.949
1.00
21.23
B
N


ATOM
8972
CA
LYS
B
34
86.498
22.479
−4.999
1.00
20.16
B
C


ATOM
8974
CB
LYS
B
34
86.832
21.737
−6.302
1.00
20.17
B
C


ATOM
8977
CG
LYS
B
34
88.013
22.319
−7.068
1.00
21.10
B
C


ATOM
8980
CD
LYS
B
34
89.338
21.743
−6.567
1.00
22.05
B
C


ATOM
8983
CE
LYS
B
34
90.538
22.487
−7.142
1.00
22.40
B
C


ATOM
8986
NZ
LYS
B
34
90.519
22.547
−8.633
1.00
22.69
B
N


ATOM
8990
C
LYS
B
34
85.379
23.488
−5.250
1.00
19.08
B
C


ATOM
8991
O
LYS
B
34
85.622
24.695
−5.277
1.00
19.11
B
O


ATOM
8993
N
ALA
B
35
84.158
22.979
−5.424
1.00
17.76
B
N


ATOM
8994
CA
ALA
B
35
82.980
23.805
−5.718
1.00
16.41
B
C


ATOM
8996
CB
ALA
B
35
81.743
22.927
−5.847
1.00
16.25
B
C


ATOM
9000
C
ALA
B
35
82.745
24.878
−4.663
1.00
15.50
B
C


ATOM
9001
O
ALA
B
35
82.464
26.028
−4.996
1.00
15.11
B
O


ATOM
9003
N
LYS
B
36
82.857
24.491
−3.395
1.00
14.95
B
N


ATOM
9004
CA
LYS
B
36
82.725
25.426
−2.277
1.00
14.49
B
C


ATOM
9006
CB
LYS
B
36
82.866
24.686
−0.941
1.00
14.64
B
C


ATOM
9009
CG
LYS
B
36
81.721
23.724
−0.624
1.00
14.95
B
C


ATOM
9012
CD
LYS
B
36
82.093
22.732
0.482
1.00
14.25
B
C


ATOM
9015
CE
LYS
B
36
82.334
23.418
1.820
1.00
12.69
B
C


ATOM
9018
NZ
LYS
B
36
82.523
22.434
2.916
1.00
10.99
B
N


ATOM
9022
C
LYS
B
36
83.768
26.541
−2.352
1.00
13.97
B
C


ATOM
9023
O
LYS
B
36
83.450
27.709
−2.129
1.00
13.72
B
O


ATOM
9025
N
LYS
B
37
85.007
26.169
−2.673
1.00
13.59
B
N


ATOM
9026
CA
LYS
B
37
86.120
27.119
−2.735
1.00
13.44
B
C


ATOM
9028
CB
LYS
B
37
87.457
26.374
−2.816
1.00
13.67
B
C


ATOM
9031
CG
LYS
B
37
88.681
27.282
−2.729
1.00
15.27
B
C


ATOM
9034
CD
LYS
B
37
89.950
26.502
−2.393
1.00
17.27
B
C


ATOM
9037
CE
LYS
B
37
91.135
27.436
−2.137
1.00
17.81
B
C


ATOM
9040
NZ
LYS
B
37
91.454
28.302
−3.312
1.00
17.07
B
N


ATOM
9044
C
LYS
B
37
86.000
28.100
−3.902
1.00
12.83
B
C


ATOM
9045
O
LYS
B
37
86.455
29.241
−3.800
1.00
12.97
B
O


ATOM
9047
N
LEU
B
38
85.398
27.655
−5.003
1.00
12.14
B
N


ATOM
9048
CA
LEU
B
38
85.198
28.508
−6.176
1.00
11.43
B
C


ATOM
9050
CB
LEU
B
38
85.176
27.669
−7.458
1.00
11.06
B
C


ATOM
9053
CG
LEU
B
38
86.459
26.883
−7.758
1.00
9.62
B
C


ATOM
9055
CD1
LEU
B
38
86.310
26.057
−9.026
1.00
6.76
B
C


ATOM
9059
CD2
LEU
B
38
87.657
27.812
−7.867
1.00
9.21
B
C


ATOM
9063
C
LEU
B
38
83.922
29.348
−6.052
1.00
11.28
B
C


ATOM
9064
O
LEU
B
38
83.926
30.532
−6.388
1.00
11.03
B
O


ATOM
9066
N
GLU
B
39
82.839
28.738
−5.570
1.00
11.37
B
N


ATOM
9067
CA
GLU
B
39
81.605
29.472
−5.271
1.00
11.49
B
C


ATOM
9069
CB
GLU
B
39
80.544
28.551
−4.657
1.00
11.84
B
C


ATOM
9072
CG
GLU
B
39
79.181
29.229
−4.440
1.00
12.44
B
C


ATOM
9075
CD
GLU
B
39
78.197
28.388
−3.639
1.00
13.61
B
C


ATOM
9076
OE1
GLU
B
39
78.576
27.309
−3.140
1.00
14.31
B
O


ATOM
9077
OE2
GLU
B
39
77.033
28.818
−3.504
1.00
13.97
B
O


ATOM
9078
C
GLU
B
39
81.891
30.611
−4.305
1.00
11.45
B
C


ATOM
9079
O
GLU
B
39
81.370
31.716
−4.466
1.00
11.54
B
O


ATOM
9081
N
ALA
B
40
82.714
30.325
−3.298
1.00
11.50
B
N


ATOM
9082
CA
ALA
B
40
83.120
31.321
−2.312
1.00
11.48
B
C


ATOM
9084
CB
ALA
B
40
84.038
30.689
−1.278
1.00
11.52
B
C


ATOM
9088
C
ALA
B
40
83.815
32.506
−2.972
1.00
11.57
B
C


ATOM
9089
O
ALA
B
40
83.515
33.661
−2.665
1.00
11.32
B
O


ATOM
9091
N
GLU
B
41
84.734
32.210
−3.886
1.00
11.81
B
N


ATOM
9092
CA
GLU
B
41
85.501
33.244
−4.580
1.00
12.06
B
C


ATOM
9094
CB
GLU
B
41
86.602
32.610
−5.437
1.00
12.41
B
C


ATOM
9097
CG
GLU
B
41
87.698
33.583
−5.862
1.00
13.10
B
C


ATOM
9100
CD
GLU
B
41
88.924
32.889
−6.430
1.00
13.35
B
C


ATOM
9101
OE1
GLU
B
41
89.231
31.755
−6.004
1.00
13.61
B
O


ATOM
9102
OE2
GLU
B
41
89.589
33.486
−7.301
1.00
13.54
B
O


ATOM
9103
C
GLU
B
41
84.596
34.128
−5.436
1.00
11.69
B
C


ATOM
9104
O
GLU
B
41
84.749
35.346
−5.452
1.00
11.44
B
O


ATOM
9106
N
VAL
B
42
83.651
33.509
−6.135
1.00
11.70
B
N


ATOM
9107
CA
VAL
B
42
82.672
34.251
−6.922
1.00
11.83
B
C


ATOM
9109
CB
VAL
B
42
81.728
33.305
−7.695
1.00
11.85
B
C


ATOM
9111
CG1
VAL
B
42
80.650
34.095
−8.419
1.00
12.24
B
C


ATOM
9115
CG2
VAL
B
42
82.513
32.460
−8.682
1.00
11.42
B
C


ATOM
9119
C
VAL
B
42
81.849
35.162
−6.015
1.00
12.05
B
C


ATOM
9120
O
VAL
B
42
81.692
36.348
−6.299
1.00
11.93
B
O


ATOM
9122
N
ARG
B
43
81.343
34.602
−4.918
1.00
12.55
B
N


ATOM
9123
CA
ARG
B
43
80.539
35.356
−3.949
1.00
13.01
B
C


ATOM
9125
CB
ARG
B
43
80.173
34.467
−2.748
1.00
13.46
B
C


ATOM
9128
CG
ARG
B
43
79.342
35.153
−1.654
1.00
14.25
B
C


ATOM
9131
CD
ARG
B
43
80.220
35.887
−0.635
1.00
14.13
B
C


ATOM
9134
NE
ARG
B
43
79.457
36.448
0.477
1.00
13.56
B
N


ATOM
9136
CZ
ARG
B
43
79.951
37.291
1.382
1.00
13.26
B
C


ATOM
9137
NH1
ARG
B
43
79.172
37.747
2.356
1.00
13.32
B
N


ATOM
9140
NH2
ARG
B
43
81.218
37.687
1.319
1.00
13.61
B
N


ATOM
9143
C
ARG
B
43
81.251
36.623
−3.474
1.00
12.51
B
C


ATOM
9144
O
ARG
B
43
80.632
37.683
−3.361
1.00
12.05
B
O


ATOM
9146
N
ARG
B
44
82.545
36.504
−3.187
1.00
12.38
B
N


ATOM
9147
CA
ARG
B
44
83.347
37.648
−2.750
1.00
12.46
B
C


ATOM
9149
CB
ARG
B
44
84.807
37.236
−2.537
1.00
12.38
B
C


ATOM
9152
CG
ARG
B
44
85.734
38.380
−2.138
1.00
11.90
B
C


ATOM
9155
CD
ARG
B
44
87.112
37.874
−1.750
1.00
10.93
B
C


ATOM
9158
NE
ARG
B
44
87.798
37.229
−2.866
1.00
10.06
B
N


ATOM
9160
CZ
ARG
B
44
89.003
36.667
−2.788
1.00
10.80
B
C


ATOM
9161
NH1
ARG
B
44
89.679
36.664
−1.643
1.00
12.55
B
N


ATOM
9164
NH2
ARG
B
44
89.539
36.103
−3.863
1.00
10.95
B
N


ATOM
9167
C
ARG
B
44
83.278
38.788
−3.758
1.00
12.62
B
C


ATOM
9168
O
ARG
B
44
83.176
39.953
−3.375
1.00
12.54
B
O


ATOM
9170
N
GLU
B
45
83.332
38.446
−5.042
1.00
12.86
B
N


ATOM
9171
CA
GLU
B
45
83.303
39.448
−6.102
1.00
13.14
B
C


ATOM
9173
CB
GLU
B
45
83.716
38.840
−7.449
1.00
13.40
B
C


ATOM
9176
CG
GLU
B
45
85.094
38.176
−7.467
1.00
13.15
B
C


ATOM
9179
CD
GLU
B
45
86.197
39.066
−6.930
1.00
12.52
B
C


ATOM
9180
OE1
GLU
B
45
86.171
40.286
−7.197
1.00
11.65
B
O


ATOM
9181
OE2
GLU
B
45
87.094
38.542
−6.239
1.00
13.46
B
O


ATOM
9182
C
GLU
B
45
81.930
40.100
−6.227
1.00
13.07
B
C


ATOM
9183
O
GLU
B
45
81.837
41.308
−6.424
1.00
13.24
B
O


ATOM
9185
N
ILE
B
46
80.870
39.308
−6.100
1.00
13.28
B
N


ATOM
9186
CA
ILE
B
46
79.505
39.831
−6.217
1.00
13.40
B
C


ATOM
9188
CB
ILE
B
46
78.450
38.696
−6.262
1.00
13.25
B
C


ATOM
9190
CG1
ILE
B
46
78.670
37.801
−7.485
1.00
12.31
B
C


ATOM
9193
CD1
ILE
B
46
77.743
36.617
−7.546
1.00
11.98
B
C


ATOM
9197
CG2
ILE
B
46
77.044
39.270
−6.318
1.00
12.44
B
C


ATOM
9201
C
ILE
B
46
79.179
40.805
−5.078
1.00
13.95
B
C


ATOM
9202
O
ILE
B
46
78.401
41.740
−5.269
1.00
13.95
B
O


ATOM
9204
N
ASN
B
47
79.788
40.589
−3.910
1.00
14.71
B
N


ATOM
9205
CA
ASN
B
47
79.621
41.476
−2.750
1.00
15.06
B
C


ATOM
9207
CB
ASN
B
47
79.428
40.644
−1.485
1.00
14.81
B
C


ATOM
9210
CG
ASN
B
47
78.236
39.728
−1.579
1.00
15.52
B
C


ATOM
9211
OD1
ASN
B
47
77.091
40.181
−1.600
1.00
15.77
B
O


ATOM
9212
ND2
ASN
B
47
78.495
38.429
−1.650
1.00
17.54
B
N


ATOM
9215
C
ASN
B
47
80.779
42.460
−2.552
1.00
15.58
B
C


ATOM
9216
O
ASN
B
47
80.888
43.093
−1.498
1.00
16.00
B
O


ATOM
9218
N
ASN
B
48
81.637
42.584
−3.563
1.00
15.89
B
N


ATOM
9219
CA
ASN
B
48
82.745
43.532
−3.535
1.00
16.06
B
C


ATOM
9221
CB
ASN
B
48
83.744
43.202
−4.650
1.00
15.90
B
C


ATOM
9224
CG
ASN
B
48
84.925
44.150
−4.685
1.00
15.28
B
C


ATOM
9225
OD1
ASN
B
48
85.262
44.783
−3.686
1.00
15.43
B
O


ATOM
9226
ND2
ASN
B
48
85.566
44.248
−5.843
1.00
15.13
B
N


ATOM
9229
C
ASN
B
48
82.214
44.951
−3.701
1.00
16.79
B
C


ATOM
9230
O
ASN
B
48
81.838
45.349
−4.806
1.00
17.02
B
O


ATOM
9232
N
GLU
B
49
82.188
45.710
−2.606
1.00
17.49
B
N


ATOM
9233
CA
GLU
B
49
81.592
47.053
−2.612
1.00
18.37
B
C


ATOM
9235
CB
GLU
B
49
81.183
47.467
−1.191
1.00
18.78
B
C


ATOM
9238
CG
GLU
B
49
80.125
46.546
−0.564
1.00
20.96
B
C


ATOM
9241
CD
GLU
B
49
79.341
47.187
0.583
1.00
23.15
B
C


ATOM
9242
OE1
GLU
B
49
78.832
46.437
1.443
1.00
23.41
B
O


ATOM
9243
OE2
GLU
B
49
79.220
48.432
0.626
1.00
25.12
B
O


ATOM
9244
C
GLU
B
49
82.484
48.132
−3.245
1.00
18.48
B
C


ATOM
9245
O
GLU
B
49
82.045
49.270
−3.411
1.00
18.18
B
O


ATOM
9247
N
LYS
B
50
83.721
47.776
−3.598
1.00
18.96
B
N


ATOM
9248
CA
LYS
B
50
84.643
48.694
−4.277
1.00
19.36
B
C


ATOM
9250
CB
LYS
B
50
86.002
48.704
−3.569
1.00
19.39
B
C


ATOM
9253
CG
LYS
B
50
85.938
48.749
−2.054
1.00
19.24
B
C


ATOM
9256
CD
LYS
B
50
87.314
49.008
−1.455
1.00
19.55
B
C


ATOM
9259
CE
LYS
B
50
87.442
48.400
−0.069
1.00
19.73
B
C


ATOM
9262
NZ
LYS
B
50
86.280
48.740
0.792
1.00
18.94
B
N


ATOM
9266
C
LYS
B
50
84.855
48.325
−5.751
1.00
19.85
B
C


ATOM
9267
O
LYS
B
50
85.860
48.711
−6.350
1.00
19.64
B
O


ATOM
9269
N
ALA
B
51
83.914
47.585
−6.335
1.00
20.78
B
N


ATOM
9270
CA
ALA
B
51
84.036
47.130
−7.721
1.00
21.39
B
C


ATOM
9272
CB
ALA
B
51
83.225
45.860
−7.932
1.00
21.43
B
C


ATOM
9276
C
ALA
B
51
83.580
48.213
−8.693
1.00
21.95
B
C


ATOM
9277
O
ALA
B
51
82.643
48.956
−8.402
1.00
21.95
B
O


ATOM
9279
N
GLU
B
52
84.248
48.298
−9.842
1.00
22.93
B
N


ATOM
9280
CA
GLU
B
52
83.864
49.240
−10.899
1.00
23.64
B
C


ATOM
9282
CB
GLU
B
52
84.892
49.243
−12.037
1.00
23.82
B
C


ATOM
9285
CG
GLU
B
52
86.280
49.747
−11.642
1.00
24.65
B
C


ATOM
9288
CD
GLU
B
52
86.415
51.257
−11.745
1.00
26.37
B
C


ATOM
9289
OE1
GLU
B
52
86.465
51.778
−12.880
1.00
27.93
B
O


ATOM
9290
OE2
GLU
B
52
86.486
51.924
−10.691
1.00
27.36
B
O


ATOM
9291
C
GLU
B
52
82.498
48.824
−11.427
1.00
23.98
B
C


ATOM
9292
O
GLU
B
52
82.289
47.653
−11.752
1.00
24.25
B
O


ATOM
9294
N
PHE
B
53
81.575
49.780
−11.505
1.00
24.11
B
N


ATOM
9295
CA
PHE
B
53
80.165
49.475
−11.772
1.00
24.15
B
C


ATOM
9297
CB
PHE
B
53
79.315
50.749
−11.715
1.00
24.51
B
C


ATOM
9300
CG
PHE
B
53
79.155
51.313
−10.324
1.00
27.60
B
C


ATOM
9301
CD1
PHE
B
53
78.559
50.556
−9.315
1.00
29.48
B
C


ATOM
9303
CE1
PHE
B
53
78.400
51.071
−8.028
1.00
30.36
B
C


ATOM
9305
CZ
PHE
B
53
78.838
52.361
−7.739
1.00
31.69
B
C


ATOM
9307
CE2
PHE
B
53
79.433
53.131
−8.739
1.00
31.11
B
C


ATOM
9309
CD2
PHE
B
53
79.586
52.606
−10.024
1.00
30.30
B
C


ATOM
9311
C
PHE
B
53
79.933
48.739
−13.095
1.00
23.44
B
C


ATOM
9312
O
PHE
B
53
79.059
47.874
−13.177
1.00
23.35
B
O


ATOM
9314
N
LEU
B
54
80.715
49.073
−14.120
1.00
22.51
B
N


ATOM
9315
CA
LEU
B
54
80.622
48.377
−15.403
1.00
21.75
B
C


ATOM
9317
CB
LEU
B
54
81.416
49.117
−16.487
1.00
21.53
B
C


ATOM
9320
CG
LEU
B
54
81.023
48.812
−17.936
1.00
21.05
B
C


ATOM
9322
CD1
LEU
B
54
79.602
49.279
−18.218
1.00
20.70
B
C


ATOM
9326
CD2
LEU
B
54
81.997
49.461
−18.908
1.00
19.68
B
C


ATOM
9330
C
LEU
B
54
81.110
46.928
−15.267
1.00
21.34
B
C


ATOM
9331
O
LEU
B
54
80.503
46.011
−15.821
1.00
21.37
B
O


ATOM
9333
N
THR
B
55
82.195
46.731
−14.517
1.00
20.71
B
N


ATOM
9334
CA
THR
B
55
82.723
45.391
−14.241
1.00
20.02
B
C


ATOM
9336
CB
THR
B
55
84.090
45.459
−13.528
1.00
19.67
B
C


ATOM
9338
OG1
THR
B
55
84.974
46.311
−14.264
1.00
18.17
B
O


ATOM
9340
CG2
THR
B
55
84.706
44.071
−13.409
1.00
19.26
B
C


ATOM
9344
C
THR
B
55
81.763
44.569
−13.379
1.00
19.89
B
C


ATOM
9345
O
THR
B
55
81.651
43.353
−13.550
1.00
19.81
B
O


ATOM
9347
N
LEU
B
56
81.077
45.242
−12.456
1.00
19.76
B
N


ATOM
9348
CA
LEU
B
56
80.128
44.592
−11.552
1.00
19.79
B
C


ATOM
9350
CB
LEU
B
56
79.630
45.591
−10.500
1.00
19.92
B
C


ATOM
9353
CG
LEU
B
56
78.637
45.086
−9.449
1.00
20.73
B
C


ATOM
9355
CD1
LEU
B
56
79.195
43.878
−8.703
1.00
21.48
B
C


ATOM
9359
CD2
LEU
B
56
78.277
46.207
−8.476
1.00
21.77
B
C


ATOM
9363
C
LEU
B
56
78.941
44.014
−12.316
1.00
19.43
B
C


ATOM
9364
O
LEU
B
56
78.580
42.850
−12.136
1.00
19.59
B
O


ATOM
9366
N
LEU
B
57
78.341
44.840
−13.167
1.00
18.85
B
N


ATOM
9367
CA
LEU
B
57
77.219
44.412
−13.997
1.00
18.27
B
C


ATOM
9369
CB
LEU
B
57
76.672
45.590
−14.808
1.00
18.24
B
C


ATOM
9372
CG
LEU
B
57
76.112
46.770
−14.008
1.00
18.19
B
C


ATOM
9374
CD1
LEU
B
57
75.894
47.973
−14.912
1.00
17.75
B
C


ATOM
9378
CD2
LEU
B
57
74.824
46.382
−13.297
1.00
18.37
B
C


ATOM
9382
C
LEU
B
57
77.649
43.289
−14.938
1.00
17.71
B
C


ATOM
9383
O
LEU
B
57
76.922
42.311
−15.114
1.00
17.47
B
O


ATOM
9385
N
GLU
B
58
78.836
43.435
−15.527
1.00
17.20
B
N


ATOM
9386
CA
GLU
B
58
79.386
42.429
−16.440
1.00
16.77
B
C


ATOM
9388
CB
GLU
B
58
80.668
42.942
−17.110
1.00
16.93
B
C


ATOM
9391
CG
GLU
B
58
80.413
43.906
−18.269
1.00
18.82
B
C


ATOM
9394
CD
GLU
B
58
81.688
44.351
−18.983
1.00
20.53
B
C


ATOM
9395
OE1
GLU
B
58
82.721
43.653
−18.876
1.00
22.18
B
O


ATOM
9396
OE2
GLU
B
58
81.652
45.400
−19.662
1.00
20.87
B
O


ATOM
9397
C
GLU
B
58
79.655
41.080
−15.764
1.00
16.01
B
C


ATOM
9398
O
GLU
B
58
79.540
40.038
−16.409
1.00
16.08
B
O


ATOM
9400
N
LEU
B
59
80.011
41.095
−14.479
1.00
14.97
B
N


ATOM
9401
CA
LEU
B
59
80.244
39.849
−13.740
1.00
13.89
B
C


ATOM
9403
CB
LEU
B
59
80.915
40.117
−12.387
1.00
13.50
B
C


ATOM
9406
CG
LEU
B
59
81.070
38.917
−11.439
1.00
11.95
B
C


ATOM
9408
CD1
LEU
B
59
81.657
37.699
−12.142
1.00
8.96
B
C


ATOM
9412
CD2
LEU
B
59
81.921
39.295
−10.243
1.00
10.77
B
C


ATOM
9416
C
LEU
B
59
78.936
39.085
−13.541
1.00
13.42
B
C


ATOM
9417
O
LEU
B
59
78.852
37.904
−13.877
1.00
13.89
B
O


ATOM
9419
N
ILE
B
60
77.924
39.761
−12.999
1.00
12.45
B
N


ATOM
9420
CA
ILE
B
60
76.607
39.148
−12.804
1.00
11.69
B
C


ATOM
9422
CB
ILE
B
60
75.533
40.169
−12.356
1.00
11.55
B
C


ATOM
9424
CG1
ILE
B
60
75.861
40.758
−10.982
1.00
11.14
B
C


ATOM
9427
CD1
ILE
B
60
74.840
41.771
−10.494
1.00
9.21
B
C


ATOM
9431
CG2
ILE
B
60
74.161
39.507
−12.311
1.00
10.73
B
C


ATOM
9435
C
ILE
B
60
76.139
38.535
−14.114
1.00
11.60
B
C


ATOM
9436
O
ILE
B
60
75.774
37.362
−14.167
1.00
11.32
B
O


ATOM
9438
N
ASP
B
61
76.168
39.348
−15.168
1.00
11.70
B
N


ATOM
9439
CA
ASP
B
61
75.739
38.927
−16.496
1.00
11.67
B
C


ATOM
9441
CB
ASP
B
61
75.996
40.041
−17.517
1.00
11.58
B
C


ATOM
9444
CG
ASP
B
61
75.344
39.772
−18.866
1.00
11.78
B
C


ATOM
9445
OD1
ASP
B
61
74.350
39.015
−18.922
1.00
9.94
B
O


ATOM
9446
OD2
ASP
B
61
75.826
40.332
−19.874
1.00
11.86
B
O


ATOM
9447
C
ASP
B
61
76.452
37.647
−16.914
1.00
11.90
B
C


ATOM
9448
O
ASP
B
61
75.823
36.740
−17.444
1.00
11.79
B
O


ATOM
9450
N
ASN
B
62
77.756
37.572
−16.660
1.00
12.59
B
N


ATOM
9451
CA
ASN
B
62
78.515
36.345
−16.917
1.00
13.39
B
C


ATOM
9453
CB
ASN
B
62
80.020
36.574
−16.725
1.00
13.48
B
C


ATOM
9456
CG
ASN
B
62
80.590
37.589
−17.699
1.00
13.93
B
C


ATOM
9457
OD1
ASN
B
62
80.077
37.768
−18.803
1.00
13.75
B
O


ATOM
9458
ND2
ASN
B
62
81.660
38.263
−17.290
1.00
16.15
B
N


ATOM
9461
C
ASN
B
62
78.049
35.192
−16.024
1.00
13.60
B
C


ATOM
9462
O
ASN
B
62
77.842
34.076
−16.500
1.00
13.11
B
O


ATOM
9464
N
VAL
B
63
77.873
35.473
−14.735
1.00
13.89
B
N


ATOM
9465
CA
VAL
B
63
77.447
34.458
−13.773
1.00
14.49
B
C


ATOM
9467
CB
VAL
B
63
77.327
35.041
−12.349
1.00
14.33
B
C


ATOM
9469
CG1
VAL
B
63
76.681
34.034
−11.410
1.00
14.92
B
C


ATOM
9473
CG2
VAL
B
63
78.693
35.452
−11.829
1.00
14.73
B
C


ATOM
9477
C
VAL
B
63
76.113
33.822
−14.170
1.00
15.20
B
C


ATOM
9478
O
VAL
B
63
75.986
32.596
−14.188
1.00
15.27
B
O


ATOM
9480
N
GLN
B
64
75.129
34.658
−14.490
1.00
15.80
B
N


ATOM
9481
CA
GLN
B
64
73.799
34.178
−14.875
1.00
16.00
B
C


ATOM
9483
CB
GLN
B
64
72.811
35.340
−14.962
1.00
16.04
B
C


ATOM
9486
CG
GLN
B
64
72.518
36.000
−13.630
1.00
16.27
B
C


ATOM
9489
CD
GLN
B
64
71.616
37.209
−13.762
1.00
16.56
B
C


ATOM
9490
OE1
GLN
B
64
70.631
37.339
−13.035
1.00
19.83
B
O


ATOM
9491
NE2
GLN
B
64
71.946
38.102
−14.693
1.00
12.79
B
N


ATOM
9494
C
GLN
B
64
73.825
33.441
−16.207
1.00
16.02
B
C


ATOM
9495
O
GLN
B
64
73.141
32.434
−16.375
1.00
16.54
B
O


ATOM
9497
N
ARG
B
65
74.612
33.950
−17.150
1.00
16.05
B
N


ATOM
9498
CA
ARG
B
65
74.721
33.338
−18.473
1.00
16.17
B
C


ATOM
9500
CB
ARG
B
65
75.346
34.315
−19.473
1.00
16.27
B
C


ATOM
9503
CG
ARG
B
65
74.403
35.458
−19.834
1.00
18.62
B
C


ATOM
9506
CD
ARG
B
65
74.945
36.347
−20.935
1.00
19.52
B
C


ATOM
9509
NE
ARG
B
65
74.972
35.651
−22.219
1.00
21.90
B
N


ATOM
9511
CZ
ARG
B
65
75.080
36.245
−23.405
1.00
25.25
B
C


ATOM
9512
NH1
ARG
B
65
75.161
37.571
−23.503
1.00
26.87
B
N


ATOM
9515
NH2
ARG
B
65
75.099
35.504
−24.509
1.00
26.60
B
N


ATOM
9518
C
ARG
B
65
75.494
32.020
−18.451
1.00
15.57
B
C


ATOM
9519
O
ARG
B
65
75.292
31.179
−19.322
1.00
16.17
B
O


ATOM
9521
N
LEU
B
66
76.361
31.838
−17.454
1.00
14.50
B
N


ATOM
9522
CA
LEU
B
66
77.091
30.575
−17.275
1.00
13.62
B
C


ATOM
9524
CB
LEU
B
66
78.445
30.836
−16.606
1.00
13.45
B
C


ATOM
9527
CG
LEU
B
66
79.441
31.662
−17.429
1.00
12.05
B
C


ATOM
9529
CD1
LEU
B
66
80.499
32.279
−16.532
1.00
11.23
B
C


ATOM
9533
CD2
LEU
B
66
80.081
30.824
−18.518
1.00
9.81
B
C


ATOM
9537
C
LEU
B
66
76.283
29.546
−16.468
1.00
13.36
B
C


ATOM
9538
O
LEU
B
66
76.797
28.480
−16.116
1.00
12.46
B
O


ATOM
9540
N
GLY
B
67
75.024
29.880
−16.175
1.00
13.57
B
N


ATOM
9541
CA
GLY
B
67
74.089
28.970
−15.518
1.00
13.40
B
C


ATOM
9544
C
GLY
B
67
74.004
29.124
−14.009
1.00
13.53
B
C


ATOM
9545
O
GLY
B
67
73.192
28.456
−13.367
1.00
13.68
B
O


ATOM
9547
N
LEU
B
68
74.812
30.020
−13.442
1.00
13.50
B
N


ATOM
9548
CA
LEU
B
68
75.000
30.092
−11.988
1.00
13.46
B
C


ATOM
9550
CB
LEU
B
68
76.484
30.330
−11.678
1.00
13.16
B
C


ATOM
9553
CG
LEU
B
68
77.467
29.318
−12.274
1.00
12.36
B
C


ATOM
9555
CD1
LEU
B
68
78.899
29.699
−11.919
1.00
11.43
B
C


ATOM
9559
CD2
LEU
B
68
77.152
27.905
−11.803
1.00
9.64
B
C


ATOM
9563
C
LEU
B
68
74.149
31.150
−11.266
1.00
13.59
B
C


ATOM
9564
O
LEU
B
68
74.430
31.485
−10.117
1.00
13.36
B
O


ATOM
9566
N
GLY
B
69
73.105
31.658
−11.916
1.00
13.93
B
N


ATOM
9567
CA
GLY
B
69
72.275
32.714
−11.327
1.00
14.33
B
C


ATOM
9570
C
GLY
B
69
71.461
32.277
−10.117
1.00
14.49
B
C


ATOM
9571
O
GLY
B
69
71.331
33.023
−9.142
1.00
14.33
B
O


ATOM
9573
N
TYR
B
70
70.910
31.067
−10.184
1.00
14.76
B
N


ATOM
9574
CA
TYR
B
70
70.127
30.493
−9.080
1.00
14.94
B
C


ATOM
9576
CB
TYR
B
70
69.535
29.136
−9.493
1.00
14.57
B
C


ATOM
9579
CG
TYR
B
70
70.532
27.992
−9.554
1.00
12.18
B
C


ATOM
9580
CD1
TYR
B
70
70.607
27.053
−8.530
1.00
9.68
B
C


ATOM
9582
CE1
TYR
B
70
71.511
25.999
−8.585
1.00
8.46
B
C


ATOM
9584
CZ
TYR
B
70
72.353
25.874
−9.673
1.00
8.09
B
C


ATOM
9585
OH
TYR
B
70
73.251
24.837
−9.733
1.00
2.16
B
O


ATOM
9587
CE2
TYR
B
70
72.300
26.789
−10.701
1.00
10.87
B
C


ATOM
9589
CD2
TYR
B
70
71.390
27.841
−10.640
1.00
12.42
B
C


ATOM
9591
C
TYR
B
70
70.929
30.328
−7.783
1.00
15.65
B
C


ATOM
9592
O
TYR
B
70
70.354
30.256
−6.696
1.00
15.92
B
O


ATOM
9594
N
ARG
B
71
72.251
30.270
−7.911
1.00
16.20
B
N


ATOM
9595
CA
ARG
B
71
73.144
30.017
−6.785
1.00
16.52
B
C


ATOM
9597
CB
ARG
B
71
74.387
29.275
−7.292
1.00
16.53
B
C


ATOM
9600
CG
ARG
B
71
75.487
29.079
−6.269
1.00
18.42
B
C


ATOM
9603
CD
ARG
B
71
76.353
27.866
−6.587
1.00
20.45
B
C


ATOM
9606
NE
ARG
B
71
75.889
26.669
−5.880
1.00
20.38
B
N


ATOM
9608
CZ
ARG
B
71
75.159
25.689
−6.412
1.00
18.95
B
C


ATOM
9609
NH1
ARG
B
71
74.803
24.658
−5.656
1.00
19.37
B
N


ATOM
9612
NH2
ARG
B
71
74.783
25.719
−7.686
1.00
18.08
B
N


ATOM
9615
C
ARG
B
71
73.536
31.290
−6.029
1.00
16.71
B
C


ATOM
9616
O
ARG
B
71
73.904
31.216
−4.856
1.00
17.32
B
O


ATOM
9618
N
PHE
B
72
73.446
32.448
−6.686
1.00
16.77
B
N


ATOM
9619
CA
PHE
B
72
73.869
33.722
−6.084
1.00
16.64
B
C


ATOM
9621
CB
PHE
B
72
75.080
34.285
−6.839
1.00
16.18
B
C


ATOM
9624
CG
PHE
B
72
76.285
33.396
−6.807
1.00
14.45
B
C


ATOM
9625
CD1
PHE
B
72
77.151
33.422
−5.726
1.00
14.72
B
C


ATOM
9627
CE1
PHE
B
72
78.270
32.602
−5.696
1.00
15.49
B
C


ATOM
9629
CZ
PHE
B
72
78.529
31.748
−6.758
1.00
14.51
B
C


ATOM
9631
CE2
PHE
B
72
77.672
31.718
−7.840
1.00
12.96
B
C


ATOM
9633
CD2
PHE
B
72
76.559
32.540
−7.861
1.00
12.86
B
C


ATOM
9635
C
PHE
B
72
72.771
34.789
−6.055
1.00
17.23
B
C


ATOM
9636
O
PHE
B
72
73.070
35.966
−5.846
1.00
17.54
B
O


ATOM
9638
N
GLU
B
73
71.511
34.392
−6.241
1.00
17.68
B
N


ATOM
9639
CA
GLU
B
73
70.417
35.362
−6.381
1.00
17.82
B
C


ATOM
9641
CB
GLU
B
73
69.044
34.677
−6.330
1.00
17.51
B
C


ATOM
9644
CG
GLU
B
73
67.872
35.639
−6.556
1.00
17.32
B
C


ATOM
9647
CD
GLU
B
73
66.574
34.938
−6.923
1.00
18.12
B
C


ATOM
9648
OE1
GLU
B
73
66.536
34.246
−7.964
1.00
17.38
B
O


ATOM
9649
OE2
GLU
B
73
65.582
35.097
−6.181
1.00
18.22
B
O


ATOM
9650
C
GLU
B
73
70.492
36.495
−5.347
1.00
18.27
B
C


ATOM
9651
O
GLU
B
73
70.561
37.666
−5.720
1.00
18.56
B
O


ATOM
9653
N
SER
B
74
70.503
36.156
−4.061
1.00
18.44
B
N


ATOM
9654
CA
SER
B
74
70.518
37.184
−3.016
1.00
19.13
B
C


ATOM
9656
CB
SER
B
74
70.471
36.564
−1.617
1.00
19.31
B
C


ATOM
9659
OG
SER
B
74
71.749
36.099
−1.218
1.00
20.88
B
O


ATOM
9661
C
SER
B
74
71.751
38.075
−3.137
1.00
19.37
B
C


ATOM
9662
O
SER
B
74
71.649
39.304
−3.058
1.00
19.55
B
O


ATOM
9664
N
ASP
B
75
72.910
37.448
−3.330
1.00
19.39
B
N


ATOM
9665
CA
ASP
B
75
74.168
38.181
−3.468
1.00
19.25
B
C


ATOM
9667
CB
ASP
B
75
75.355
37.219
−3.618
1.00
18.87
B
C


ATOM
9670
CG
ASP
B
75
75.559
36.340
−2.387
1.00
18.85
B
C


ATOM
9671
OD1
ASP
B
75
76.370
36.708
−1.510
1.00
15.51
B
O


ATOM
9672
OD2
ASP
B
75
74.897
35.284
−2.293
1.00
19.53
B
O


ATOM
9673
C
ASP
B
75
74.090
39.139
−4.656
1.00
19.33
B
C


ATOM
9674
O
ASP
B
75
74.564
40.274
−4.579
1.00
19.40
B
O


ATOM
9676
N
ILE
B
76
73.466
38.682
−5.739
1.00
19.53
B
N


ATOM
9677
CA
ILE
B
76
73.258
39.509
−6.927
1.00
19.92
B
C


ATOM
9679
CB
ILE
B
76
72.762
38.664
−8.128
1.00
19.83
B
C


ATOM
9681
CG1
ILE
B
76
73.868
37.717
−8.599
1.00
19.94
B
C


ATOM
9684
CD1
ILE
B
76
73.384
36.631
−9.528
1.00
21.34
B
C


ATOM
9688
CG2
ILE
B
76
72.335
39.560
−9.283
1.00
19.40
B
C


ATOM
9692
C
ILE
B
76
72.277
40.652
−6.647
1.00
20.43
B
C


ATOM
9693
O
ILE
B
76
72.535
41.796
−7.028
1.00
20.62
B
O


ATOM
9695
N
ARG
B
77
71.165
40.342
−5.977
1.00
20.78
B
N


ATOM
9696
CA
ARG
B
77
70.175
41.360
−5.595
1.00
21.05
B
C


ATOM
9698
CB
ARG
B
77
68.985
40.722
−4.877
1.00
21.27
B
C


ATOM
9701
CG
ARG
B
77
68.098
39.864
−5.760
1.00
23.04
B
C


ATOM
9704
CD
ARG
B
77
67.085
39.093
−4.924
1.00
25.79
B
C


ATOM
9707
NE
ARG
B
77
66.125
39.989
−4.281
1.00
27.15
B
N


ATOM
9709
CZ
ARG
B
77
65.054
40.514
−4.878
1.00
28.90
B
C


ATOM
9710
NH1
ARG
B
77
64.777
40.244
−6.152
1.00
29.24
B
N


ATOM
9713
NH2
ARG
B
77
64.251
41.320
−4.193
1.00
30.29
B
N


ATOM
9716
C
ARG
B
77
70.785
42.436
−4.697
1.00
20.82
B
C


ATOM
9717
O
ARG
B
77
70.469
43.618
−4.833
1.00
20.93
B
O


ATOM
9719
N
GLY
B
78
71.653
42.016
−3.780
1.00
20.58
B
N


ATOM
9720
CA
GLY
B
78
72.387
42.943
−2.924
1.00
20.53
B
C


ATOM
9723
C
GLY
B
78
73.409
43.788
−3.670
1.00
20.38
B
C


ATOM
9724
O
GLY
B
78
73.801
44.851
−3.193
1.00
20.60
B
O


ATOM
9726
N
ALA
B
79
73.847
43.313
−4.835
1.00
20.03
B
N


ATOM
9727
CA
ALA
B
79
74.777
44.060
−5.680
1.00
20.01
B
C


ATOM
9729
CB
ALA
B
79
75.425
43.132
−6.694
1.00
20.01
B
C


ATOM
9733
C
ALA
B
79
74.077
45.210
−6.396
1.00
20.07
B
C


ATOM
9734
O
ALA
B
79
74.580
46.333
−6.424
1.00
19.81
B
O


ATOM
9736
N
LEU
B
80
72.918
44.921
−6.981
1.00
20.65
B
N


ATOM
9737
CA
LEU
B
80
72.145
45.928
−7.706
1.00
21.23
B
C


ATOM
9739
CB
LEU
B
80
71.039
45.265
−8.533
1.00
21.22
B
C


ATOM
9742
CG
LEU
B
80
71.509
44.313
−9.637
1.00
22.04
B
C


ATOM
9744
CD1
LEU
B
80
70.315
43.623
−10.295
1.00
22.93
B
C


ATOM
9748
CD2
LEU
B
80
72.349
45.047
−10.677
1.00
21.09
B
C


ATOM
9752
C
LEU
B
80
71.538
46.967
−6.764
1.00
21.81
B
C


ATOM
9753
O
LEU
B
80
71.402
48.135
−7.129
1.00
22.20
B
O


ATOM
9755
N
ASP
B
81
71.178
46.544
−5.555
1.00
22.17
B
N


ATOM
9756
CA
ASP
B
81
70.651
47.463
−4.543
1.00
22.35
B
C


ATOM
9758
CB
ASP
B
81
70.188
46.692
−3.303
1.00
22.43
B
C


ATOM
9761
CG
ASP
B
81
69.122
47.433
−2.521
1.00
23.43
B
C


ATOM
9762
OD1
ASP
B
81
69.403
47.854
−1.377
1.00
24.99
B
O


ATOM
9763
OD2
ASP
B
81
68.004
47.598
−3.055
1.00
23.01
B
O


ATOM
9764
C
ASP
B
81
71.705
48.509
−4.158
1.00
22.33
B
C


ATOM
9765
O
ASP
B
81
71.374
49.658
−3.862
1.00
22.00
B
O


ATOM
9767
N
ARG
B
82
72.970
48.091
−4.160
1.00
22.64
B
N


ATOM
9768
CA
ARG
B
82
74.110
48.997
−3.992
1.00
23.00
B
C


ATOM
9770
CB
ARG
B
82
75.429
48.207
−3.977
1.00
23.31
B
C


ATOM
9773
CG
ARG
B
82
76.436
48.600
−2.894
1.00
23.85
B
C


ATOM
9776
CD
ARG
B
82
76.608
47.462
−1.902
1.00
25.49
B
C


ATOM
9779
NE
ARG
B
82
77.031
46.237
−2.588
1.00
27.67
B
N


ATOM
9781
CZ
ARG
B
82
76.736
44.993
−2.208
1.00
28.92
B
C


ATOM
9782
NH1
ARG
B
82
75.999
44.755
−1.125
1.00
29.74
B
N


ATOM
9785
NH2
ARG
B
82
77.175
43.967
−2.929
1.00
28.09
B
N


ATOM
9788
C
ARG
B
82
74.150
49.964
−5.168
1.00
22.98
B
C


ATOM
9789
O
ARG
B
82
74.309
51.174
−4.997
1.00
23.04
B
O


ATOM
9791
N
PHE
B
83
74.012
49.394
−6.363
1.00
22.90
B
N


ATOM
9792
CA
PHE
B
83
74.097
50.131
−7.620
1.00
22.96
B
C


ATOM
9794
CB
PHE
B
83
73.907
49.159
−8.788
1.00
22.83
B
C


ATOM
9797
CG
PHE
B
83
74.055
49.790
−10.137
1.00
22.79
B
C


ATOM
9798
CD1
PHE
B
83
75.264
50.338
−10.527
1.00
22.61
B
C


ATOM
9800
CE1
PHE
B
83
75.411
50.916
−11.776
1.00
23.30
B
C


ATOM
9802
CZ
PHE
B
83
74.340
50.941
−12.656
1.00
23.91
B
C


ATOM
9804
CE2
PHE
B
83
73.126
50.391
−12.281
1.00
23.32
B
C


ATOM
9806
CD2
PHE
B
83
72.989
49.816
−11.029
1.00
23.33
B
C


ATOM
9808
C
PHE
B
83
73.081
51.269
−7.701
1.00
23.09
B
C


ATOM
9809
O
PHE
B
83
73.424
52.381
−8.102
1.00
23.19
B
O


ATOM
9811
N
VAL
B
84
71.840
50.989
−7.312
1.00
23.08
B
N


ATOM
9812
CA
VAL
B
84
70.778
51.996
−7.336
1.00
23.11
B
C


ATOM
9814
CB
VAL
B
84
69.379
51.347
−7.184
1.00
23.15
B
C


ATOM
9816
CG1
VAL
B
84
68.319
52.402
−6.884
1.00
22.64
B
C


ATOM
9820
CG2
VAL
B
84
69.019
50.564
−8.441
1.00
22.66
B
C


ATOM
9824
C
VAL
B
84
70.969
53.048
−6.244
1.00
23.28
B
C


ATOM
9825
O
VAL
B
84
70.892
54.248
−6.513
1.00
23.33
B
O


ATOM
9827
N
SER
B
85
71.223
52.590
−5.020
1.00
23.59
B
N


ATOM
9828
CA
SER
B
85
71.289
53.472
−3.848
1.00
23.83
B
C


ATOM
9830
CB
SER
B
85
71.287
52.643
−2.559
1.00
24.07
B
C


ATOM
9833
OG
SER
B
85
72.375
51.733
−2.529
1.00
25.24
B
O


ATOM
9835
C
SER
B
85
72.493
54.417
−3.851
1.00
23.55
B
C


ATOM
9836
O
SER
B
85
72.401
55.534
−3.342
1.00
23.23
B
O


ATOM
9838
N
SER
B
86
73.612
53.973
−4.425
1.00
23.60
B
N


ATOM
9839
CA
SER
B
86
74.814
54.810
−4.524
1.00
23.71
B
C


ATOM
9841
CB
SER
B
86
76.076
53.937
−4.571
1.00
23.57
B
C


ATOM
9844
OG
SER
B
86
76.163
53.204
−5.781
1.00
23.18
B
O


ATOM
9846
C
SER
B
86
74.784
55.748
−5.738
1.00
23.94
B
C


ATOM
9847
O
SER
B
86
75.764
56.444
−6.007
1.00
23.67
B
O


ATOM
9849
N
GLY
B
87
73.664
55.764
−6.462
1.00
24.30
B
N


ATOM
9850
CA
GLY
B
87
73.511
56.602
−7.648
1.00
24.62
B
C


ATOM
9853
C
GLY
B
87
74.240
56.061
−8.866
1.00
24.97
B
C


ATOM
9854
O
GLY
B
87
74.698
56.832
−9.711
1.00
25.27
B
O


ATOM
9856
N
GLY
B
88
74.350
54.737
−8.960
1.00
25.14
B
N


ATOM
9857
CA
GLY
B
88
75.008
54.090
−10.096
1.00
25.27
B
C


ATOM
9860
C
GLY
B
88
74.123
54.077
−11.330
1.00
25.47
B
C


ATOM
9861
O
GLY
B
88
74.598
54.303
−12.446
1.00
25.09
B
O


ATOM
9863
N
PHE
B
89
72.834
53.811
−11.123
1.00
25.86
B
N


ATOM
9864
CA
PHE
B
89
71.847
53.814
−12.206
1.00
26.07
B
C


ATOM
9866
CB
PHE
B
89
70.486
53.334
−11.688
1.00
26.21
B
C


ATOM
9869
CG
PHE
B
89
69.389
53.363
−12.723
1.00
26.68
B
C


ATOM
9870
CD1
PHE
B
89
69.523
52.660
−13.915
1.00
26.40
B
C


ATOM
9872
CE1
PHE
B
89
68.513
52.681
−14.871
1.00
26.69
B
C


ATOM
9874
CZ
PHE
B
89
67.350
53.404
−14.636
1.00
27.08
B
C


ATOM
9876
CE2
PHE
B
89
67.202
54.104
−13.448
1.00
27.35
B
C


ATOM
9878
CD2
PHE
B
89
68.217
54.080
−12.498
1.00
27.23
B
C


ATOM
9880
C
PHE
B
89
71.714
55.204
−12.818
1.00
26.15
B
C


ATOM
9881
O
PHE
B
89
71.593
55.344
−14.035
1.00
26.29
B
O


ATOM
9883
N
ASP
B
90
71.741
56.224
−11.964
1.00
26.08
B
N


ATOM
9884
CA
ASP
B
90
71.678
57.612
−12.411
1.00
26.14
B
C


ATOM
9886
CB
ASP
B
90
71.389
58.536
−11.222
1.00
26.54
B
C


ATOM
9889
CG
ASP
B
90
70.904
59.914
−11.651
1.00
28.73
B
C


ATOM
9890
OD1
ASP
B
90
71.751
60.801
−11.913
1.00
29.84
B
O


ATOM
9891
OD2
ASP
B
90
69.671
60.112
−11.709
1.00
31.49
B
O


ATOM
9892
C
ASP
B
90
72.971
58.042
−13.113
1.00
25.74
B
C


ATOM
9893
O
ASP
B
90
72.949
58.939
−13.955
1.00
26.14
B
O


ATOM
9895
N
ALA
B
91
74.089
57.400
−12.770
1.00
25.04
B
N


ATOM
9896
CA
ALA
B
91
75.395
57.742
−13.343
1.00
24.47
B
C


ATOM
9898
CB
ALA
B
91
76.517
57.190
−12.470
1.00
24.49
B
C


ATOM
9902
C
ALA
B
91
75.555
57.246
−14.780
1.00
23.98
B
C


ATOM
9903
O
ALA
B
91
75.966
58.005
−15.657
1.00
23.86
B
O


ATOM
9905
N
VAL
B
92
75.231
55.976
−15.016
1.00
23.68
B
N


ATOM
9906
CA
VAL
B
92
75.405
55.365
−16.341
1.00
23.29
B
C


ATOM
9908
CB
VAL
B
92
75.211
53.832
−16.307
1.00
23.10
B
C


ATOM
9910
CG1
VAL
B
92
76.248
53.187
−15.399
1.00
22.67
B
C


ATOM
9914
CG2
VAL
B
92
73.795
53.473
−15.868
1.00
23.29
B
C


ATOM
9918
C
VAL
B
92
74.474
55.949
−17.406
1.00
23.09
B
C


ATOM
9919
O
VAL
B
92
74.862
56.059
−18.569
1.00
23.06
B
O


ATOM
9921
N
THR
B
93
73.260
56.333
−17.009
1.00
22.98
B
N


ATOM
9922
CA
THR
B
93
72.277
56.894
−17.948
1.00
22.80
B
C


ATOM
9924
CB
THR
B
93
70.887
57.094
−17.293
1.00
22.75
B
C


ATOM
9926
OG1
THR
B
93
71.002
57.966
−16.161
1.00
21.89
B
O


ATOM
9928
CG2
THR
B
93
70.299
55.756
−16.859
1.00
22.59
B
C


ATOM
9932
C
THR
B
93
72.721
58.224
−18.567
1.00
22.54
B
C


ATOM
9933
O
THR
B
93
72.142
58.664
−19.562
1.00
22.69
B
O


ATOM
9935
N
LYS
B
94
73.734
58.857
−17.974
1.00
22.08
B
N


ATOM
9936
CA
LYS
B
94
74.346
60.061
−18.539
1.00
21.85
B
C


ATOM
9938
CB
LYS
B
94
74.849
60.989
−17.422
1.00
21.89
B
C


ATOM
9941
CG
LYS
B
94
73.825
61.316
−16.333
1.00
22.60
B
C


ATOM
9944
CD
LYS
B
94
72.573
61.989
−16.885
1.00
23.74
B
C


ATOM
9947
CE
LYS
B
94
71.570
62.282
−15.779
1.00
24.01
B
C


ATOM
9950
NZ
LYS
B
94
70.262
62.747
−16.319
1.00
23.58
B
N


ATOM
9954
C
LYS
B
94
75.509
59.724
−19.479
1.00
21.38
B
C


ATOM
9955
O
LYS
B
94
75.748
60.447
−20.450
1.00
21.29
B
O


ATOM
9957
N
THR
B
95
76.219
58.629
−19.193
1.00
20.80
B
N


ATOM
9958
CA
THR
B
95
77.463
58.288
−19.898
1.00
20.16
B
C


ATOM
9960
CB
THR
B
95
78.598
57.987
−18.892
1.00
20.05
B
C


ATOM
9962
OG1
THR
B
95
78.226
56.884
−18.054
1.00
19.86
B
O


ATOM
9964
CG2
THR
B
95
78.882
59.208
−18.027
1.00
19.17
B
C


ATOM
9968
C
THR
B
95
77.337
57.110
−20.880
1.00
19.76
B
C


ATOM
9969
O
THR
B
95
77.331
57.315
−22.097
1.00
19.67
B
O


ATOM
9971
N
SER
B
96
77.238
55.889
−20.352
1.00
19.17
B
N


ATOM
9972
CA
SER
B
96
77.321
54.673
−21.172
1.00
18.55
B
C


ATOM
9974
CB
SER
B
96
78.197
53.631
−20.474
1.00
18.28
B
C


ATOM
9977
OG
SER
B
96
78.356
52.478
−21.284
1.00
16.95
B
O


ATOM
9979
C
SER
B
96
75.957
54.055
−21.474
1.00
18.37
B
C


ATOM
9980
O
SER
B
96
75.124
53.907
−20.581
1.00
18.51
B
O


ATOM
9982
N
LEU
B
97
75.749
53.681
−22.737
1.00
18.03
B
N


ATOM
9983
CA
LEU
B
97
74.538
52.970
−23.156
1.00
17.63
B
C


ATOM
9985
CB
LEU
B
97
74.358
53.060
−24.676
1.00
17.43
B
C


ATOM
9988
CG
LEU
B
97
73.200
52.279
−25.308
1.00
16.33
B
C


ATOM
9990
CD1
LEU
B
97
71.862
52.622
−24.663
1.00
14.88
B
C


ATOM
9994
CD2
LEU
B
97
73.158
52.544
−26.799
1.00
15.23
B
C


ATOM
9998
C
LEU
B
97
74.616
51.509
−22.721
1.00
17.57
B
C


ATOM
9999
O
LEU
B
97
73.726
51.012
−22.031
1.00
17.48
B
O


ATOM
10001
N
HIS
B
98
75.685
50.833
−23.135
1.00
17.59
B
N


ATOM
10002
CA
HIS
B
98
75.953
49.450
−22.732
1.00
17.51
B
C


ATOM
10004
CB
HIS
B
98
77.430
49.107
−22.981
1.00
17.79
B
C


ATOM
10007
CG
HIS
B
98
77.888
47.849
−22.309
1.00
18.71
B
C


ATOM
10008
ND1
HIS
B
98
77.360
46.610
−22.602
1.00
20.03
B
N


ATOM
10010
CE1
HIS
B
98
77.959
45.693
−21.863
1.00
20.85
B
C


ATOM
10012
NE2
HIS
B
98
78.861
46.291
−21.106
1.00
20.28
B
N


ATOM
10014
CD2
HIS
B
98
78.839
47.639
−21.367
1.00
19.98
B
C


ATOM
10016
C
HIS
B
98
75.606
49.243
−21.265
1.00
17.07
B
C


ATOM
10017
O
HIS
B
98
74.733
48.441
−20.934
1.00
17.09
B
O


ATOM
10019
N
GLY
B
99
76.280
49.994
−20.399
1.00
16.69
B
N


ATOM
10020
CA
GLY
B
99
76.080
49.903
−18.956
1.00
16.27
B
C


ATOM
10023
C
GLY
B
99
74.644
50.107
−18.510
1.00
15.82
B
C


ATOM
10024
O
GLY
B
99
74.218
49.516
−17.518
1.00
15.84
B
O


ATOM
10026
N
THR
B
100
73.902
50.946
−19.233
1.00
15.36
B
N


ATOM
10027
CA
THR
B
100
72.492
51.200
−18.928
1.00
15.12
B


ATOM
10029
CB
THR
B
100
71.989
52.511
−19.582
1.00
15.04
B
C


ATOM
10031
OG1
THR
B
100
72.701
53.626
−19.034
1.00
14.95
B
O


ATOM
10033
CG2
THR
B
100
70.500
52.706
−19.336
1.00
14.68
B
C


ATOM
10037
C
THR
B
100
71.612
50.036
−19.380
1.00
14.98
B
C


ATOM
10038
O
THR
B
100
70.745
49.587
−18.636
1.00
14.55
B
O


ATOM
10040
N
ALA
B
101
71.846
49.552
−20.596
1.00
15.35
B
N


ATOM
10041
CA
ALA
B
101
71.059
48.452
−21.162
1.00
15.58
B
C


ATOM
10043
CB
ALA
B
101
71.386
48.281
−22.637
1.00
15.49
B
C


ATOM
10047
C
ALA
B
101
71.281
47.135
−20.413
1.00
15.71
B
C


ATOM
10048
O
ALA
B
101
70.392
46.278
−20.369
1.00
16.00
B
O


ATOM
10050
N
LEU
B
102
72.470
46.978
−19.838
1.00
15.43
B
N


ATOM
10051
CA
LEU
B
102
72.788
45.817
−19.011
1.00
15.11
B
C


ATOM
10053
CB
LEU
B
102
74.306
45.698
−18.828
1.00
14.88
B
C


ATOM
10056
CG
LEU
B
102
74.848
44.512
−18.029
1.00
13.96
B
C


ATOM
10058
CD1
LEU
B
102
74.261
43.198
−18.515
1.00
13.62
B
C


ATOM
10062
CD2
LEU
B
102
76.369
44.488
−18.109
1.00
13.07
B
C


ATOM
10066
C
LEU
B
102
72.096
45.934
−17.654
1.00
15.05
B
C


ATOM
10067
O
LEU
B
102
71.425
45.000
−17.210
1.00
15.13
B
O


ATOM
10069
N
SER
B
103
72.254
47.089
−17.010
1.00
14.64
B
N


ATOM
10070
CA
SER
B
103
71.667
47.325
−15.695
1.00
14.21
B
C


ATOM
10072
CB
SER
B
103
72.208
48.613
−15.068
1.00
14.05
B
C


ATOM
10075
OG
SER
B
103
71.690
49.766
−15.705
1.00
13.39
B
O


ATOM
10077
C
SER
B
103
70.148
47.383
−15.764
1.00
14.45
B
C


ATOM
10078
O
SER
B
103
69.471
46.896
−14.862
1.00
15.34
B
O


ATOM
10080
N
PHE
B
104
69.611
47.976
−16.827
1.00
14.20
B
N


ATOM
10081
CA
PHE
B
104
68.163
48.010
−17.017
1.00
13.83
B
C


ATOM
10083
CB
PHE
B
104
67.792
48.649
−18.356
1.00
14.07
B
C


ATOM
10086
CG
PHE
B
104
66.311
48.706
−18.608
1.00
14.64
B
C


ATOM
10087
CD1
PHE
B
104
65.589
49.850
−18.309
1.00
15.83
B
C


ATOM
10089
CE1
PHE
B
104
64.220
49.905
−18.538
1.00
16.59
B
C


ATOM
10091
CZ
PHE
B
104
63.562
48.807
−19.068
1.00
16.05
B
C


ATOM
10093
CE2
PHE
B
104
64.272
47.660
−19.368
1.00
15.67
B
C


ATOM
10095
CD2
PHE
B
104
65.639
47.612
−19.140
1.00
15.20
B
C


ATOM
10097
C
PHE
B
104
67.627
46.594
−16.966
1.00
13.24
B
C


ATOM
10098
O
PHE
B
104
66.718
46.295
−16.194
1.00
13.15
B
O


ATOM
10100
N
ARG
B
105
68.211
45.731
−17.794
1.00
13.05
B
N


ATOM
10101
CA
ARG
B
105
67.795
44.334
−17.904
1.00
13.08
B
C


ATOM
10103
CB
ARG
B
105
68.620
43.617
−18.977
1.00
13.37
B
C


ATOM
10106
CG
ARG
B
105
68.162
42.196
−19.273
1.00
13.35
B
C


ATOM
10109
CD
ARG
B
105
68.759
41.681
−20.576
1.00
12.99
B
C


ATOM
10112
NE
ARG
B
105
70.219
41.615
−20.518
1.00
12.68
B
N


ATOM
10114
CZ
ARG
B
105
70.918
40.672
−19.885
1.00
10.95
B
C


ATOM
10115
NH1
ARG
B
105
70.309
39.686
−19.231
1.00
9.34
B
N


ATOM
10118
NH2
ARG
B
105
72.246
40.718
−19.902
1.00
10.70
B
N


ATOM
10121
C
ARG
B
105
67.936
43.602
−16.578
1.00
12.52
B
C


ATOM
10122
O
ARG
B
105
66.992
42.967
−16.106
1.00
12.65
B
O


ATOM
10124
N
LEU
B
106
69.119
43.697
−15.983
1.00
11.82
B
N


ATOM
10125
CA
LEU
B
106
69.380
43.060
−14.699
1.00
11.23
B
C


ATOM
10127
CB
LEU
B
106
70.827
43.314
−14.255
1.00
10.81
B
C


ATOM
10130
CG
LEU
B
106
71.911
42.650
−15.109
1.00
8.27
B
C


ATOM
10132
CD1
LEU
B
106
73.282
43.156
−14.714
1.00
6.17
B
C


ATOM
10136
CD2
LEU
B
106
71.845
41.141
−14.993
1.00
6.13
B
C


ATOM
10140
C
LEU
B
106
68.395
43.548
−13.635
1.00
11.04
B
C


ATOM
10141
O
LEU
B
106
67.783
42.745
−12.939
1.00
10.80
B
O


ATOM
10143
N
LEU
B
107
68.229
44.862
−13.528
1.00
11.29
B
N


ATOM
10144
CA
LEU
B
107
67.332
45.436
−12.525
1.00
11.68
B
C


ATOM
10146
CB
LEU
B
107
67.324
46.967
−12.603
1.00
11.63
B
C


ATOM
10149
CG
LEU
B
107
68.511
47.671
−11.943
1.00
10.96
B
C


ATOM
10151
CD1
LEU
B
107
68.589
49.129
−12.377
1.00
9.53
B
C


ATOM
10155
CD2
LEU
B
107
68.414
47.555
−10.424
1.00
11.26
B
C


ATOM
10159
C
LEU
B
107
65.912
44.901
−12.671
1.00
11.95
B
C


ATOM
10160
O
LEU
B
107
65.323
44.423
−11.700
1.00
12.00
B
O


ATOM
10162
N
ARG
B
108
65.370
44.972
−13.882
1.00
12.17
B
N


ATOM
10163
CA
ARG
B
108
64.004
44.516
−14.122
1.00
12.61
B
C


ATOM
10165
CB
ARG
B
108
63.535
44.888
−15.526
1.00
12.46
B
C


ATOM
10168
CG
ARG
B
108
62.082
44.523
−15.779
1.00
11.97
B
C


ATOM
10171
CD
ARG
B
108
61.486
45.308
−16.924
1.00
11.34
B
C


ATOM
10174
NE
ARG
B
108
61.210
46.693
−16.555
1.00
10.21
B
N


ATOM
10176
CZ
ARG
B
108
60.650
47.590
−17.362
1.00
10.94
B
C


ATOM
10177
NH1
ARG
B
108
60.296
47.265
−18.603
1.00
10.42
B
N


ATOM
10180
NH2
ARG
B
108
60.443
48.825
−16.924
1.00
11.87
B
N


ATOM
10183
C
ARG
B
108
63.867
43.011
−13.905
1.00
13.23
B
C


ATOM
10184
O
ARG
B
108
62.876
42.554
−13.338
1.00
13.51
B
O


ATOM
10186
N
GLN
B
109
64.861
42.252
−14.359
1.00
13.93
B
N


ATOM
10187
CA
GLN
B
109
64.893
40.802
−14.148
1.00
14.40
B
C


ATOM
10189
CB
GLN
B
109
66.224
40.225
−14.650
1.00
14.43
B
C


ATOM
10192
CG
GLN
B
109
66.353
38.709
−14.555
1.00
13.91
B
C


ATOM
10195
CD
GLN
B
109
67.800
38.247
−14.560
1.00
12.71
B
C


ATOM
10196
OE1
GLN
B
109
68.652
38.840
−15.222
1.00
12.98
B
O


ATOM
10197
NE2
GLN
B
109
68.083
37.183
−13.819
1.00
12.06
B
N


ATOM
10200
C
GLN
B
109
64.695
40.461
−12.670
1.00
14.82
B
C


ATOM
10201
O
GLN
B
109
63.935
39.551
−12.336
1.00
15.14
B
O


ATOM
10203
N
HIS
B
110
65.369
41.208
−11.795
1.00
15.02
B
N


ATOM
10204
CA
HIS
B
110
65.307
40.977
−10.351
1.00
15.34
B
C


ATOM
10206
CB
HIS
B
110
66.702
41.147
−9.732
1.00
15.49
B
C


ATOM
10209
CG
HIS
B
110
67.692
40.110
−10.168
1.00
14.40
B
C


ATOM
10210
ND1
HIS
B
110
67.790
38.876
−9.563
1.00
13.44
B
N


ATOM
10212
CE1
HIS
B
110
68.749
38.178
−10.145
1.00
13.56
B
C


ATOM
10214
NE2
HIS
B
110
69.280
38.917
−11.101
1.00
11.71
B
N


ATOM
10216
CD2
HIS
B
110
68.639
40.130
−11.135
1.00
12.93
B
C


ATOM
10218
C
HIS
B
110
64.300
41.899
−9.644
1.00
15.77
B
C


ATOM
10219
O
HIS
B
110
64.591
42.451
−8.578
1.00
15.94
B
O


ATOM
10221
N
GLY
B
111
63.127
42.075
−10.248
1.00
16.02
B
N


ATOM
10222
CA
GLY
B
111
61.992
42.729
−9.590
1.00
16.43
B
C


ATOM
10225
C
GLY
B
111
62.109
44.199
−9.205
1.00
16.88
B
C


ATOM
10226
O
GLY
B
111
61.257
44.708
−8.474
1.00
16.73
B
O


ATOM
10228
N
PHE
B
112
63.143
44.890
−9.683
1.00
17.42
B
N


ATOM
10229
CA
PHE
B
112
63.274
46.328
−9.438
1.00
17.67
B
C


ATOM
10231
CB
PHE
B
112
64.722
46.798
−9.597
1.00
17.98
B
C


ATOM
10234
CG
PHE
B
112
65.615
46.412
−8.460
1.00
19.28
B
C


ATOM
10235
CD1
PHE
B
112
65.605
47.143
−7.281
1.00
20.60
B
C


ATOM
10237
CE1
PHE
B
112
66.431
46.796
−6.222
1.00
22.44
B
C


ATOM
10239
CZ
PHE
B
112
67.287
45.710
−6.339
1.00
22.18
B
C


ATOM
10241
CE2
PHE
B
112
67.309
44.976
−7.515
1.00
21.88
B
C


ATOM
10243
CD2
PHE
B
112
66.477
45.329
−8.569
1.00
20.40
B
C


ATOM
10245
C
PHE
B
112
62.397
47.100
−10.406
1.00
17.64
B
C


ATOM
10246
O
PHE
B
112
62.039
46.594
−11.470
1.00
17.30
B
O


ATOM
10248
N
GLU
B
113
62.053
48.329
−10.036
1.00
18.13
B
N


ATOM
10249
CA
GLU
B
113
61.356
49.217
−10.952
1.00
18.59
B
C


ATOM
10251
CB
GLU
B
113
60.339
50.108
−10.227
1.00
18.94
B
C


ATOM
10254
CG
GLU
B
113
59.591
51.062
−11.178
1.00
20.95
B
C


ATOM
10257
CD
GLU
B
113
58.188
51.435
−10.710
1.00
22.45
B
C


ATOM
10258
OE1
GLU
B
113
57.949
51.484
−9.485
1.00
25.01
B
O


ATOM
10259
OE2
GLU
B
113
57.324
51.691
−11.577
1.00
21.27
B
O


ATOM
10260
C
GLU
B
113
62.375
50.068
−11.697
1.00
18.18
B
C


ATOM
10261
O
GLU
B
113
63.150
50.806
−11.085
1.00
17.81
B
O


ATOM
10263
N
VAL
B
114
62.378
49.924
−13.020
1.00
17.96
B
N


ATOM
10264
CA
VAL
B
114
63.109
50.814
−13.915
1.00
17.72
B
C


ATOM
10266
CB
VAL
B
114
64.338
50.121
−14.540
1.00
17.40
B
C


ATOM
10268
CG1
VAL
B
114
65.341
49.766
−13.458
1.00
16.56
B
C


ATOM
10272
CG2
VAL
B
114
63.925
48.880
−15.324
1.00
17.16
B
C


ATOM
10276
C
VAL
B
114
62.152
51.303
−15.005
1.00
17.86
B
C


ATOM
10277
O
VAL
B
114
61.067
50.746
−15.183
1.00
17.45
B
O


ATOM
10279
N
SER
B
115
62.554
52.351
−15.719
1.00
18.11
B
N


ATOM
10280
CA
SER
B
115
61.695
52.993
−16.713
1.00
17.98
B
C


ATOM
10282
CB
SER
B
115
61.151
54.311
−16.155
1.00
17.76
B
C


ATOM
10285
OG
SER
B
115
60.269
54.934
−17.070
1.00
17.43
B
O


ATOM
10287
C
SER
B
115
62.451
53.247
−18.016
1.00
18.09
B
C


ATOM
10288
O
SER
B
115
63.661
53.487
−18.006
1.00
18.38
B
O


ATOM
10290
N
GLN
B
116
61.724
53.199
−19.132
1.00
17.77
B
N


ATOM
10291
CA
GLN
B
116
62.300
53.431
−20.460
1.00
17.40
B
C


ATOM
10293
CB
GLN
B
116
61.235
53.251
−21.548
1.00
17.53
B
C


ATOM
10296
CG
GLN
B
116
60.133
54.317
−21.543
1.00
18.28
B
C


ATOM
10299
CD
GLN
B
116
58.938
53.944
−22.404
1.00
17.36
B
C


ATOM
10300
OE1
GLN
B
116
59.065
53.210
−23.385
1.00
17.59
B
O


ATOM
10301
NE2
GLN
B
116
57.770
54.456
−22.041
1.00
15.98
B
N


ATOM
10304
C
GLN
B
116
62.944
54.812
−20.589
1.00
17.28
B
C


ATOM
10305
O
GLN
B
116
63.751
55.035
−21.488
1.00
17.66
B
O


ATOM
10307
N
GLU
B
117
62.586
55.731
−19.693
1.00
17.24
B
N


ATOM
10308
CA
GLU
B
117
63.225
57.050
−19.625
1.00
17.35
B
C


ATOM
10310
CB
GLU
B
117
62.455
57.969
−18.666
1.00
17.33
B
C


ATOM
10313
CG
GLU
B
117
61.062
58.369
−19.160
1.00
16.64
B
C


ATOM
10316
CD
GLU
B
117
61.092
59.306
−20.364
1.00
15.94
B
C


ATOM
10317
OE1
GLU
B
117
62.165
59.872
−20.667
1.00
13.31
B
O


ATOM
10318
OE2
GLU
B
117
60.034
59.479
−21.008
1.00
15.83
B
O


ATOM
10319
C
GLU
B
117
64.706
56.987
−19.218
1.00
17.41
B
C


ATOM
10320
O
GLU
B
117
65.398
58.005
−19.230
1.00
17.10
B
O


ATOM
10322
N
ALA
B
118
65.184
55.799
−18.848
1.00
17.79
B
N


ATOM
10323
CA
ALA
B
118
66.614
55.563
−18.667
1.00
18.07
B
C


ATOM
10325
CB
ALA
B
118
66.852
54.162
−18.121
1.00
17.97
B
C


ATOM
10329
C
ALA
B
118
67.360
55.748
−19.986
1.00
18.33
B
C


ATOM
10330
O
ALA
B
118
68.491
56.234
−20.004
1.00
18.49
B
O


ATOM
10332
N
PHE
B
119
66.711
55.369
−21.085
1.00
18.76
B
N


ATOM
10333
CA
PHE
B
119
67.313
55.448
−22.414
1.00
19.32
B
C


ATOM
10335
CB
PHE
B
119
66.785
54.310
−23.300
1.00
19.27
B
C


ATOM
10338
CG
PHE
B
119
67.039
52.933
−22.742
1.00
18.34
B
C


ATOM
10339
CD1
PHE
B
119
65.987
52.138
−22.305
1.00
17.02
B
C


ATOM
10341
CE1
PHE
B
119
66.219
50.871
−21.791
1.00
17.25
B
C


ATOM
10343
CZ
PHE
B
119
67.514
50.384
−21.706
1.00
17.67
B
C


ATOM
10345
CE2
PHE
B
119
68.574
51.166
−22.137
1.00
17.65
B
C


ATOM
10347
CD2
PHE
B
119
68.333
52.433
−22.653
1.00
18.36
B
C


ATOM
10349
C
PHE
B
119
67.075
56.794
−23.114
1.00
20.18
B
C


ATOM
10350
O
PHE
B
119
67.387
56.933
−24.298
1.00
20.87
B
O


ATOM
10352
N
SER
B
120
66.537
57.781
−22.396
1.00
20.76
B
N


ATOM
10353
CA
SER
B
120
66.253
59.099
−22.982
1.00
20.91
B
C


ATOM
10355
CB
SER
B
120
65.240
59.870
−22.129
1.00
20.93
B
C


ATOM
10358
OG
SER
B
120
65.837
60.372
−20.944
1.00
21.26
B
O


ATOM
10360
C
SER
B
120
67.515
59.945
−23.177
1.00
20.98
B
C


ATOM
10361
O
SER
B
120
67.497
60.912
−23.937
1.00
21.13
B
O


ATOM
10363
N
GLY
B
121
68.601
59.584
−22.496
1.00
21.23
B
N


ATOM
10364
CA
GLY
B
121
69.884
60.267
−22.667
1.00
21.73
B
C


ATOM
10367
C
GLY
B
121
70.734
59.725
−23.808
1.00
22.23
B
C


ATOM
10368
O
GLY
B
121
71.951
59.924
−23.821
1.00
21.96
B
O


ATOM
10370
N
PHE
B
122
70.098
59.038
−24.762
1.00
22.81
B
N


ATOM
10371
CA
PHE
B
122
70.789
58.447
−25.913
1.00
23.32
B
C


ATOM
10373
CB
PHE
B
122
71.029
56.945
−25.680
1.00
23.17
B
C


ATOM
10376
CG
PHE
B
122
71.721
56.627
−24.382
1.00
22.98
B
C


ATOM
10377
CD1
PHE
B
122
73.108
56.588
−24.308
1.00
22.49
B
C


ATOM
10379
CE1
PHE
B
122
73.750
56.293
−23.107
1.00
22.39
B
C


ATOM
10381
CZ
PHE
B
122
73.002
56.034
−21.968
1.00
22.47
B
C


ATOM
10383
CE2
PHE
B
122
71.617
56.067
−22.030
1.00
23.14
B
C


ATOM
10385
CD2
PHE
B
122
70.984
56.361
−23.234
1.00
23.30
B
C


ATOM
10387
C
PHE
B
122
69.984
58.640
−27.204
1.00
23.76
B
C


ATOM
10388
O
PHE
B
122
69.948
57.751
−28.056
1.00
23.82
B
O


ATOM
10390
N
LYS
B
123
69.348
59.803
−27.349
1.00
24.39
B
N


ATOM
10391
CA
LYS
B
123
68.464
60.075
−28.490
1.00
24.99
B
C


ATOM
10393
CB
LYS
B
123
66.996
59.960
−28.061
1.00
25.11
B
C


ATOM
10396
CG
LYS
B
123
66.579
58.554
−27.623
1.00
26.36
B
C


ATOM
10399
CD
LYS
B
123
65.256
58.547
−26.858
1.00
27.49
B
C


ATOM
10402
CE
LYS
B
123
64.056
58.691
−27.782
1.00
28.01
B
C


ATOM
10405
NZ
LYS
B
123
63.822
57.472
−28.611
1.00
28.15
B
N


ATOM
10409
C
LYS
B
123
68.728
61.456
−29.106
1.00
25.23
B
C


ATOM
10410
O
LYS
B
123
68.984
62.428
−28.391
1.00
25.22
B
O


ATOM
10412
N
ASP
B
124
68.647
61.529
−30.435
1.00
25.37
B
N


ATOM
10413
CA
ASP
B
124
68.960
62.755
−31.185
1.00
25.33
B
C


ATOM
10415
CB
ASP
B
124
69.203
62.423
−32.673
1.00
25.38
B
C


ATOM
10418
CG
ASP
B
124
67.946
61.934
−33.398
1.00
24.90
B
C


ATOM
10419
OD1
ASP
B
124
66.838
61.988
−32.824
1.00
23.59
B
O


ATOM
10420
OD2
ASP
B
124
68.072
61.489
−34.558
1.00
23.99
B
O


ATOM
10421
C
ASP
B
124
67.882
63.840
−31.028
1.00
25.30
B
C


ATOM
10422
O
ASP
B
124
66.943
63.683
−30.243
1.00
25.33
B
O


ATOM
10424
N
GLN
B
125
68.032
64.938
−31.770
1.00
25.13
B
N


ATOM
10425
CA
GLN
B
125
67.047
66.026
−31.767
1.00
25.14
B
C


ATOM
10427
CB
GLN
B
125
67.458
67.128
−32.750
1.00
25.16
B
C


ATOM
10430
CG
GLN
B
125
68.471
68.123
−32.187
1.00
25.92
B
C


ATOM
10433
CD
GLN
B
125
67.855
69.137
−31.228
1.00
25.99
B
C


ATOM
10434
OE1
GLN
B
125
66.688
69.032
−30.849
1.00
26.31
B
O


ATOM
10435
NE2
GLN
B
125
68.646
70.126
−30.832
1.00
25.52
B
N


ATOM
10438
C
GLN
B
125
65.633
65.545
−32.098
1.00
25.09
B
C


ATOM
10439
O
GLN
B
125
64.675
65.901
−31.409
1.00
25.17
B
O


ATOM
10441
N
ASN
B
126
65.511
64.738
−33.149
1.00
24.90
B
N


ATOM
10442
CA
ASN
B
126
64.213
64.199
−33.567
1.00
24.53
B
C


ATOM
10444
CB
ASN
B
126
64.337
63.471
−34.911
1.00
24.47
B
C


ATOM
10447
CG
ASN
B
126
64.510
64.422
−36.078
1.00
24.13
B
C


ATOM
10448
OD1
ASN
B
126
65.064
65.511
−35.930
1.00
23.55
B
O


ATOM
10449
ND2
ASN
B
126
64.033
64.015
−37.249
1.00
23.27
B
N


ATOM
10452
C
ASN
B
126
63.578
63.257
−32.545
1.00
24.35
B
C


ATOM
10453
O
ASN
B
126
62.352
63.204
−32.430
1.00
24.38
B
O


ATOM
10455
N
GLY
B
127
64.411
62.524
−31.808
1.00
23.98
B
N


ATOM
10456
CA
GLY
B
127
63.938
61.494
−30.881
1.00
23.80
B
C


ATOM
10459
C
GLY
B
127
64.216
60.076
−31.357
1.00
23.59
B
C


ATOM
10460
O
GLY
B
127
63.608
59.124
−30.865
1.00
23.44
B
O


ATOM
10462
N
ASN
B
128
65.117
59.939
−32.330
1.00
23.46
B
N


ATOM
10463
CA
ASN
B
128
65.661
58.641
−32.721
1.00
23.17
B
C


ATOM
10465
CB
ASN
B
128
65.918
58.577
−34.232
1.00
23.19
B
C


ATOM
10468
CG
ASN
B
128
64.713
59.001
−35.056
1.00
22.48
B
C


ATOM
10469
OD1
ASN
B
128
64.149
60.075
−34.846
1.00
20.86
B
O


ATOM
10470
ND2
ASN
B
128
64.323
58.162
−36.010
1.00
21.21
B
N


ATOM
10473
C
ASN
B
128
66.972
58.432
−31.980
1.00
22.97
B
C


ATOM
10474
O
ASN
B
128
67.583
59.394
−31.515
1.00
22.71
B
O


ATOM
10476
N
PHE
B
129
67.408
57.182
−31.870
1.00
22.94
B
N


ATOM
10477
CA
PHE
B
129
68.691
56.885
−31.234
1.00
22.94
B
C


ATOM
10479
CB
PHE
B
129
68.859
55.380
−31.017
1.00
23.04
B
C


ATOM
10482
CG
PHE
B
129
68.061
54.844
−29.863
1.00
24.12
B
C


ATOM
10483
CD1
PHE
B
129
66.708
54.559
−30.011
1.00
25.06
B
C


ATOM
10485
CE1
PHE
B
129
65.965
54.066
−28.946
1.00
25.61
B
C


ATOM
10487
CZ
PHE
B
129
66.575
53.850
−27.718
1.00
25.88
B
C


ATOM
10489
CE2
PHE
B
129
67.926
54.130
−27.559
1.00
25.30
B
C


ATOM
10491
CD2
PHE
B
129
68.661
54.625
−28.628
1.00
24.47
B
C


ATOM
10493
C
PHE
B
129
69.827
57.432
−32.091
1.00
22.78
B
C


ATOM
10494
O
PHE
B
129
69.719
57.474
−33.320
1.00
22.90
B
O


ATOM
10496
N
LEU
B
130
70.907
57.862
−31.441
1.00
22.49
B
N


ATOM
10497
CA
LEU
B
130
72.045
58.435
−32.154
1.00
22.33
B
C


ATOM
10499
CB
LEU
B
130
73.095
58.980
−31.178
1.00
22.14
B
C


ATOM
10502
CG
LEU
B
130
72.731
60.262
−30.422
1.00
21.49
B
C


ATOM
10504
CD1
LEU
B
130
73.833
60.628
−29.442
1.00
20.84
B
C


ATOM
10508
CD2
LEU
B
130
72.469
61.414
−31.383
1.00
20.96
B
C


ATOM
10512
C
LEU
B
130
72.672
57.393
−33.075
1.00
22.54
B
C


ATOM
10513
O
LEU
B
130
73.072
56.320
−32.626
1.00
22.34
B
O


ATOM
10515
N
GLU
B
131
72.730
57.721
−34.365
1.00
23.02
B
N


ATOM
10516
CA
GLU
B
131
73.337
56.863
−35.387
1.00
23.37
B
C


ATOM
10518
CB
GLU
B
131
73.410
57.629
−36.718
1.00
23.40
B
C


ATOM
10521
CG
GLU
B
131
74.128
56.913
−37.870
1.00
24.01
B
C


ATOM
10524
CD
GLU
B
131
73.300
55.813
−38.517
1.00
25.54
B
C


ATOM
10525
OE1
GLU
B
131
72.271
55.395
−37.939
1.00
26.84
B
O


ATOM
10526
OE2
GLU
B
131
73.688
55.362
−39.616
1.00
26.70
B
O


ATOM
10527
C
GLU
B
131
74.732
56.388
−34.976
1.00
23.61
B
C


ATOM
10528
O
GLU
B
131
75.065
55.213
−35.130
1.00
23.84
B
O


ATOM
10530
N
ASN
B
132
75.531
57.306
−34.438
1.00
23.67
B
N


ATOM
10531
CA
ASN
B
132
76.923
57.024
−34.060
1.00
23.74
B
C


ATOM
10533
CB
ASN
B
132
77.674
58.343
−33.806
1.00
23.96
B
C


ATOM
10536
CG
ASN
B
132
76.916
59.285
−32.884
1.00
24.66
B
C


ATOM
10537
OD1
ASN
B
132
76.613
58.945
−31.739
1.00
25.44
B
O


ATOM
10538
ND2
ASN
B
132
76.604
60.477
−33.384
1.00
24.88
B
N


ATOM
10541
C
ASN
B
132
77.118
56.056
−32.873
1.00
23.55
B
C


ATOM
10542
O
ASN
B
132
78.253
55.791
−32.469
1.00
23.42
B
O


ATOM
10544
N
LEU
B
133
76.022
55.535
−32.322
1.00
23.55
B
N


ATOM
10545
CA
LEU
B
133
76.087
54.480
−31.303
1.00
23.52
B
C


ATOM
10547
CB
LEU
B
133
74.870
54.555
−30.370
1.00
23.31
B
C


ATOM
10550
CG
LEU
B
133
74.750
55.823
−29.521
1.00
22.53
B
C


ATOM
10552
CD1
LEU
B
133
73.383
55.904
−28.862
1.00
20.74
B
C


ATOM
10556
CD2
LEU
B
133
75.857
55.886
−28.477
1.00
22.10
B
C


ATOM
10560
C
LEU
B
133
76.180
53.075
−31.916
1.00
23.65
B
C


ATOM
10561
O
LEU
B
133
76.404
52.102
−31.193
1.00
23.81
B
O


ATOM
10563
N
LYS
B
134
76.011
52.970
−33.237
1.00
23.51
B
N


ATOM
10564
CA
LYS
B
134
76.111
51.681
−33.931
1.00
23.40
B
C


ATOM
10566
CB
LYS
B
134
75.613
51.790
−35.382
1.00
23.26
B
C


ATOM
10569
CG
LYS
B
134
76.593
52.452
−36.356
1.00
23.29
B
C


ATOM
10572
CD
LYS
B
134
76.009
52.566
−37.761
1.00
22.10
B
C


ATOM
10575
CE
LYS
B
134
77.047
53.064
−38.759
1.00
20.46
B
C


ATOM
10578
NZ
LYS
B
134
76.503
53.139
−40.141
1.00
18.74
B
N


ATOM
10582
C
LYS
B
134
77.539
51.126
−33.907
1.00
23.60
B
C


ATOM
10583
O
LYS
B
134
77.736
49.915
−34.006
1.00
23.60
B
O


ATOM
10585
N
GLU
B
135
78.525
52.014
−33.780
1.00
23.90
B
N


ATOM
10586
CA
GLU
B
135
79.934
51.615
−33.743
1.00
24.13
B
C


ATOM
10588
CB
GLU
B
135
80.853
52.842
−33.837
1.00
24.42
B
C


ATOM
10591
CG
GLU
B
135
80.740
53.633
−35.149
1.00
25.24
B
C


ATOM
10594
CD
GLU
B
135
81.137
52.832
−36.384
1.00
25.99
B
C


ATOM
10595
OE1
GLU
B
135
81.957
51.895
−36.266
1.00
25.85
B
O


ATOM
10596
OE2
GLU
B
135
80.629
53.148
−37.482
1.00
26.38
B
O


ATOM
10597
C
GLU
B
135
80.275
50.800
−32.493
1.00
23.93
B
C


ATOM
10598
O
GLU
B
135
81.150
49.934
−32.542
1.00
24.05
B
O


ATOM
10600
N
ASP
B
136
79.596
51.078
−31.382
1.00
23.74
B
N


ATOM
10601
CA
ASP
B
136
79.752
50.270
−30.172
1.00
23.80
B
C


ATOM
10603
CB
ASP
B
136
79.424
51.090
−28.914
1.00
23.79
B
C


ATOM
10606
CG
ASP
B
136
80.046
50.506
−27.647
1.00
23.69
B
C


ATOM
10607
OD1
ASP
B
136
80.288
49.280
−27.589
1.00
22.19
B
O


ATOM
10608
OD2
ASP
B
136
80.295
51.282
−26.701
1.00
24.10
B
O


ATOM
10609
C
ASP
B
136
78.855
49.031
−30.280
1.00
23.77
B
C


ATOM
10610
O
ASP
B
136
77.667
49.080
−29.957
1.00
23.85
B
O


ATOM
10612
N
ILE
B
137
79.438
47.927
−30.743
1.00
23.58
B
N


ATOM
10613
CA
ILE
B
137
78.701
46.674
−30.945
1.00
23.48
B
C


ATOM
10615
CB
ILE
B
137
79.553
45.638
−31.734
1.00
23.47
B
C


ATOM
10617
CG1
ILE
B
137
79.750
46.086
−33.189
1.00
23.86
B
C


ATOM
10620
CD1
ILE
B
137
80.947
46.990
−33.413
1.00
23.96
B
C


ATOM
10624
CG2
ILE
B
137
78.900
44.261
−31.712
1.00
23.85
B
C


ATOM
10628
C
ILE
B
137
78.242
46.065
−29.612
1.00
23.33
B
C


ATOM
10629
O
ILE
B
137
77.241
45.344
−29.559
1.00
23.33
B
O


ATOM
10631
N
LYS
B
138
78.974
46.368
−28.543
1.00
22.92
B
N


ATOM
10632
CA
LYS
B
138
78.647
45.884
−27.202
1.00
22.45
B
C


ATOM
10634
CB
LYS
B
138
79.815
46.177
−26.252
1.00
22.66
B
C


ATOM
10637
CG
LYS
B
138
80.011
45.168
−25.136
1.00
23.58
B
C


ATOM
10640
CD
LYS
B
138
80.951
45.726
−24.063
1.00
25.04
B
C


ATOM
10643
CE
LYS
B
138
81.815
44.644
−23.430
1.00
25.73
B
C


ATOM
10646
NZ
LYS
B
138
82.936
44.235
−24.324
1.00
25.22
B
N


ATOM
10650
C
LYS
B
138
77.364
46.542
−26.673
1.00
21.59
B
C


ATOM
10651
O
LYS
B
138
76.492
45.864
−26.123
1.00
21.40
B
O


ATOM
10653
N
ALA
B
139
77.258
47.860
−26.853
1.00
20.48
B
N


ATOM
10654
CA
ALA
B
139
76.130
48.643
−26.335
1.00
19.64
B
C


ATOM
10656
CB
ALA
B
139
76.479
50.125
−26.324
1.00
19.54
B
C


ATOM
10660
C
ALA
B
139
74.841
48.416
−27.118
1.00
19.12
B
C


ATOM
10661
O
ALA
B
139
73.756
48.368
−26.535
1.00
19.04
B
O


ATOM
10663
N
ILE
B
140
74.961
48.292
−28.437
1.00
18.59
B
N


ATOM
10664
CA
ILE
B
140
73.814
47.982
−29.291
1.00
18.11
B
C


ATOM
10666
CB
ILE
B
140
74.197
47.979
−30.791
1.00
18.07
B
C


ATOM
10668
CG1
ILE
B
140
74.613
49.380
−31.254
1.00
18.28
B
C


ATOM
10671
CD1
ILE
B
140
73.475
50.378
−31.350
1.00
18.35
B
C


ATOM
10675
CG2
ILE
B
140
73.040
47.471
−31.646
1.00
17.81
B
C


ATOM
10679
C
ILE
B
140
73.234
46.614
−28.928
1.00
17.72
B
C


ATOM
10680
O
ILE
B
140
72.017
46.443
−28.889
1.00
18.01
B
O


ATOM
10682
N
LEU
B
141
74.108
45.648
−28.657
1.00
17.08
B
N


ATOM
10683
CA
LEU
B
141
73.674
44.295
−28.331
1.00
16.61
B
C


ATOM
10685
CB
LEU
B
141
74.854
43.324
−28.386
1.00
16.26
B
C


ATOM
10688
CG
LEU
B
141
74.528
41.828
−28.324
1.00
15.01
B
C


ATOM
10690
CD1
LEU
B
141
73.243
41.487
−29.069
1.00
13.84
B
C


ATOM
10694
CD2
LEU
B
141
75.696
41.020
−28.873
1.00
14.21
B
C


ATOM
10698
C
LEU
B
141
73.003
44.233
−26.963
1.00
16.78
B
C


ATOM
10699
O
LEU
B
141
71.933
43.640
−26.820
1.00
17.29
B
O


ATOM
10701
N
SER
B
142
73.624
44.843
−25.958
1.00
16.60
B
N


ATOM
10702
CA
SER
B
142
73.015
44.911
−24.627
1.00
16.64
B
C


ATOM
10704
CB
SER
B
142
73.944
45.607
−23.625
1.00
16.83
B
C


ATOM
10707
OG
SER
B
142
74.964
44.727
−23.179
1.00
16.19
B
O


ATOM
10709
C
SER
B
142
71.659
45.621
−24.692
1.00
16.43
B
C


ATOM
10710
O
SER
B
142
70.700
45.194
−24.048
1.00
16.17
B
O


ATOM
10712
N
LEU
B
143
71.589
46.697
−25.474
1.00
16.32
B
N


ATOM
10713
CA
LEU
B
143
70.322
47.380
−25.743
1.00
16.29
B
C


ATOM
10715
CB
LEU
B
143
70.539
48.590
−26.664
1.00
15.94
B
C


ATOM
10718
CG
LEU
B
143
69.296
49.191
−27.331
1.00
15.20
B
C


ATOM
10720
CD1
LEU
B
143
68.240
49.558
−26.301
1.00
13.55
B
C


ATOM
10724
CD2
LEU
B
143
69.678
50.402
−28.160
1.00
15.26
B
C


ATOM
10728
C
LEU
B
143
69.312
46.415
−26.365
1.00
16.70
B
C


ATOM
10729
O
LEU
B
143
68.150
46.375
−25.957
1.00
17.42
B
O


ATOM
10731
N
TYR
B
144
69.765
45.644
−27.350
1.00
16.53
B
N


ATOM
10732
CA
TYR
B
144
68.921
44.657
−28.024
1.00
16.27
B
C


ATOM
10734
CB
TYR
B
144
69.718
43.942
−29.118
1.00
16.16
B
C


ATOM
10737
CG
TYR
B
144
69.051
42.714
−29.692
1.00
15.78
B
C


ATOM
10738
CD1
TYR
B
144
67.955
42.822
−30.541
1.00
15.10
B
C


ATOM
10740
CE1
TYR
B
144
67.349
41.697
−31.077
1.00
14.61
B
C


ATOM
10742
CZ
TYR
B
144
67.844
40.447
−30.769
1.00
15.60
B
C


ATOM
10743
OH
TYR
B
144
67.251
39.325
−31.297
1.00
19.22
B
O


ATOM
10745
CE2
TYR
B
144
68.933
40.314
−29.932
1.00
16.86
B
C


ATOM
10747
CD2
TYR
B
144
69.531
41.444
−29.401
1.00
16.55
B
C


ATOM
10749
C
TYR
B
144
68.336
43.641
−27.046
1.00
16.32
B
C


ATOM
10750
O
TYR
B
144
67.143
43.348
−27.094
1.00
16.33
B
O


ATOM
10752
N
GLU
B
145
69.178
43.116
−26.159
1.00
16.42
B
N


ATOM
10753
CA
GLU
B
145
68.738
42.136
−25.162
1.00
16.72
B
C


ATOM
10755
CB
GLU
B
145
69.940
41.586
−24.382
1.00
16.57
B
C


ATOM
10758
CG
GLU
B
145
70.940
40.787
−25.221
1.00
16.50
B
C


ATOM
10761
CD
GLU
B
145
70.436
39.406
−25.610
1.00
16.57
B
C


ATOM
10762
OE1
GLU
B
145
69.275
39.069
−25.290
1.00
17.83
B
O


ATOM
10763
OE2
GLU
B
145
71.208
38.652
−26.240
1.00
16.22
B
O


ATOM
10764
C
GLU
B
145
67.718
42.732
−24.184
1.00
16.86
B
C


ATOM
10765
O
GLU
B
145
66.768
42.055
−23.773
1.00
16.50
B
O


ATOM
10767
N
ALA
B
146
67.918
44.004
−23.832
1.00
16.74
B
N


ATOM
10768
CA
ALA
B
146
67.088
44.687
−22.838
1.00
16.36
B
C


ATOM
10770
CB
ALA
B
146
67.859
45.847
−22.219
1.00
15.89
B
C


ATOM
10774
C
ALA
B
146
65.760
45.187
−23.402
1.00
16.26
B
C


ATOM
10775
O
ALA
B
146
64.922
45.683
−22.650
1.00
16.44
B
O


ATOM
10777
N
SER
B
147
65.568
45.064
−24.713
1.00
16.21
B
N


ATOM
10778
CA
SER
B
147
64.326
45.496
−25.354
1.00
16.38
B
C


ATOM
10780
CB
SER
B
147
64.536
45.662
−26.862
1.00
16.51
B
C


ATOM
10783
OG
SER
B
147
64.814
44.420
−27.489
1.00
17.36
B
O


ATOM
10785
C
SER
B
147
63.163
44.531
−25.096
1.00
16.24
B
C


ATOM
10786
O
SER
B
147
62.015
44.959
−24.969
1.00
15.95
B
O


ATOM
10788
N
PHE
B
148
63.467
43.237
−25.009
1.00
16.34
B
N


ATOM
10789
CA
PHE
B
148
62.435
42.198
−24.890
1.00
16.34
B
C


ATOM
10791
CB
PHE
B
148
63.026
40.816
−25.190
1.00
16.30
B
C


ATOM
10794
CG
PHE
B
148
63.444
40.640
−26.620
1.00
17.03
B
C


ATOM
10795
CD1
PHE
B
148
62.570
40.093
−27.548
1.00
18.20
B
C


ATOM
10797
CE1
PHE
B
148
62.948
39.938
−28.877
1.00
19.13
B
C


ATOM
10799
CZ
PHE
B
148
64.213
40.335
−29.287
1.00
18.33
B
C


ATOM
10801
CE2
PHE
B
148
65.093
40.887
−28.369
1.00
17.95
B
C


ATOM
10803
CD2
PHE
B
148
64.705
41.039
−27.044
1.00
17.59
B
C


ATOM
10805
C
PHE
B
148
61.738
42.187
−23.530
1.00
16.13
B
C


ATOM
10806
O
PHE
B
148
60.615
41.695
−23.415
1.00
15.72
B
O


ATOM
10808
N
LEU
B
149
62.391
42.750
−22.514
1.00
16.32
B
N


ATOM
10809
CA
LEU
B
149
61.811
42.840
−21.171
1.00
16.28
B
C


ATOM
10811
CB
LEU
B
149
62.910
43.001
−20.117
1.00
15.75
B
C


ATOM
10814
CG
LEU
B
149
63.883
41.829
−20.010
1.00
15.12
B
C


ATOM
10816
CD1
LEU
B
149
65.018
41.960
−21.017
1.00
14.29
B
C


ATOM
10820
CD2
LEU
B
149
64.430
41.725
−18.598
1.00
15.76
B
C


ATOM
10824
C
LEU
B
149
60.816
43.995
−21.049
1.00
16.79
B
C


ATOM
10825
O
LEU
B
149
60.382
44.327
−19.943
1.00
17.29
B
O


ATOM
10827
N
ALA
B
150
60.451
44.597
−22.182
1.00
16.76
B
N


ATOM
10828
CA
ALA
B
150
59.538
45.736
−22.205
1.00
16.50
B
C


ATOM
10830
CB
ALA
B
150
59.404
46.271
−23.627
1.00
16.43
B
C


ATOM
10834
C
ALA
B
150
58.163
45.397
−21.646
1.00
16.20
B
C


ATOM
10835
O
ALA
B
150
57.838
44.230
−21.406
1.00
15.98
B
O


ATOM
10837
N
LEU
B
151
57.368
46.440
−21.437
1.00
16.11
B
N


ATOM
10838
CA
LEU
B
151
55.992
46.298
−20.982
1.00
16.14
B
C


ATOM
10840
CB
LEU
B
151
55.809
46.980
−19.625
1.00
16.21
B
C


ATOM
10843
CG
LEU
B
151
56.718
46.502
−18.488
1.00
15.32
B
C


ATOM
10845
CD1
LEU
B
151
56.599
47.436
−17.293
1.00
13.46
B
C


ATOM
10849
CD2
LEU
B
151
56.397
45.066
−18.088
1.00
13.69
B
C


ATOM
10853
C
LEU
B
151
55.044
46.910
−22.008
1.00
16.00
B
C


ATOM
10854
O
LEU
B
151
55.475
47.599
−22.936
1.00
15.95
B
O


ATOM
10856
N
GLU
B
152
53.752
46.651
−21.830
1.00
15.76
B
N


ATOM
10857
CA
GLU
B
152
52.730
47.163
−22.734
1.00
15.95
B
C


ATOM
10859
CB
GLU
B
152
51.356
46.595
−22.363
1.00
16.09
B
C


ATOM
10862
CG
GLU
B
152
50.504
46.178
−23.560
1.00
17.01
B
C


ATOM
10865
CD
GLU
B
152
49.009
46.229
−23.277
1.00
17.41
B
C


ATOM
10866
OE1
GLU
B
152
48.623
46.417
−22.103
1.00
17.43
B
O


ATOM
10867
OE2
GLU
B
152
48.216
46.086
−24.233
1.00
17.21
B
O


ATOM
10868
C
GLU
B
152
52.700
48.689
−22.649
1.00
16.18
B
C


ATOM
10869
O
GLU
B
152
52.615
49.243
−21.554
1.00
16.81
B
O


ATOM
10871
N
GLY
B
153
52.789
49.362
−23.795
1.00
16.13
B
N


ATOM
10872
CA
GLY
B
153
52.784
50.828
−23.839
1.00
15.84
B
C


ATOM
10875
C
GLY
B
153
54.164
51.469
−23.884
1.00
15.69
B
C


ATOM
10876
O
GLY
B
153
54.307
52.590
−24.373
1.00
15.81
B
O


ATOM
10878
N
GLU
B
154
55.178
50.771
−23.374
1.00
15.51
B
N


ATOM
10879
CA
GLU
B
154
56.550
51.282
−23.382
1.00
15.70
B
C


ATOM
10881
CB
GLU
B
154
57.448
50.439
−22.467
1.00
15.97
B
C


ATOM
10884
CG
GLU
B
154
57.054
50.515
−20.994
1.00
16.22
B
C


ATOM
10887
CD
GLU
B
154
58.095
49.917
−20.062
1.00
15.63
B
C


ATOM
10888
OE1
GLU
B
154
58.417
50.567
−19.046
1.00
12.92
B
O


ATOM
10889
OE2
GLU
B
154
58.590
48.802
−20.341
1.00
16.00
B
O


ATOM
10890
C
GLU
B
154
57.105
51.317
−24.807
1.00
15.67
B
C


ATOM
10891
O
GLU
B
154
57.757
50.375
−25.262
1.00
15.68
B
O


ATOM
10893
N
ASN
B
155
56.843
52.423
−25.498
1.00
15.69
B
N


ATOM
10894
CA
ASN
B
155
57.164
52.547
−26.924
1.00
15.77
B
C


ATOM
10896
CB
ASN
B
155
56.417
53.741
−27.552
1.00
15.68
B
C


ATOM
10899
CG
ASN
B
155
56.741
55.074
−26.883
1.00
15.48
B
C


ATOM
10900
OD1
ASN
B
155
57.898
55.377
−26.591
1.00
15.65
B
O


ATOM
10901
ND2
ASN
B
155
55.711
55.882
−26.655
1.00
14.42
B
N


ATOM
10904
C
ASN
B
155
58.661
52.613
−27.260
1.00
15.85
B
C


ATOM
10905
O
ASN
B
155
59.062
52.208
−28.351
1.00
16.36
B
O


ATOM
10907
N
ILE
B
156
59.478
53.117
−26.335
1.00
15.40
B
N


ATOM
10908
CA
ILE
B
156
60.903
53.345
−26.610
1.00
14.84
B
C


ATOM
10910
CB
ILE
B
156
61.565
54.261
−25.548
1.00
14.77
B
C


ATOM
10912
CG1
ILE
B
156
60.846
55.612
−25.479
1.00
14.33
B
C


ATOM
10915
CD1
ILE
B
156
61.588
56.669
−24.686
1.00
13.21
B
C


ATOM
10919
CG2
ILE
B
156
63.038
54.486
−25.870
1.00
14.12
B
C


ATOM
10923
C
ILE
B
156
61.690
52.037
−26.718
1.00
14.66
B
C


ATOM
10924
O
ILE
B
156
62.621
51.939
−27.516
1.00
14.69
B
O


ATOM
10926
N
LEU
B
157
61.319
51.038
−25.922
1.00
14.65
B
N


ATOM
10927
CA
LEU
B
157
61.992
49.735
−25.974
1.00
14.75
B
C


ATOM
10929
CB
LEU
B
157
61.576
48.846
−24.796
1.00
14.48
B
C


ATOM
10932
CG
LEU
B
157
62.394
49.043
−23.516
1.00
13.97
B
C


ATOM
10934
CD1
LEU
B
157
62.541
50.515
−23.164
1.00
15.30
B
C


ATOM
10938
CD2
LEU
B
157
61.766
48.288
−22.364
1.00
13.93
B
C


ATOM
10942
C
LEU
B
157
61.744
49.022
−27.306
1.00
15.28
B
C


ATOM
10943
O
LEU
B
157
62.644
48.368
−27.832
1.00
15.56
B
O


ATOM
10945
N
ASP
B
158
60.536
49.158
−27.849
1.00
15.69
B
N


ATOM
10946
CA
ASP
B
158
60.230
48.641
−29.184
1.00
16.04
B
C


ATOM
10948
CB
ASP
B
158
58.766
48.888
−29.546
1.00
16.00
B
C


ATOM
10951
CG
ASP
B
158
57.807
48.095
−28.682
1.00
17.24
B
C


ATOM
10952
OD1
ASP
B
158
58.224
47.607
−27.609
1.00
19.56
B
O


ATOM
10953
OD2
ASP
B
158
56.630
47.963
−29.081
1.00
17.24
B
O


ATOM
10954
C
ASP
B
158
61.127
49.307
−30.222
1.00
16.55
B
C


ATOM
10955
O
ASP
B
158
61.746
48.625
−31.041
1.00
16.41
B
O


ATOM
10957
N
GLU
B
159
61.192
50.640
−30.171
1.00
17.24
B
N


ATOM
10958
CA
GLU
B
159
62.070
51.427
−31.045
1.00
17.47
B
C


ATOM
10960
CB
GLU
B
159
61.967
52.923
−30.728
1.00
17.55
B
C


ATOM
10963
CG
GLU
B
159
60.630
53.563
−31.057
1.00
19.36
B
C


ATOM
10966
CD
GLU
B
159
60.517
54.982
−30.511
1.00
22.03
B
C


ATOM
10967
OE1
GLU
B
159
61.422
55.804
−30.782
1.00
21.37
B
O


ATOM
10968
OE2
GLU
B
159
59.522
55.273
−29.812
1.00
23.93
B
O


ATOM
10969
C
GLU
B
159
63.522
50.995
−30.887
1.00
17.46
B
C


ATOM
10970
O
GLU
B
159
64.280
50.984
−31.856
1.00
17.74
B
O


ATOM
10972
N
ALA
B
160
63.900
50.651
−29.656
1.00
17.33
B
N


ATOM
10973
CA
ALA
B
160
65.238
50.152
−29.361
1.00
17.26
B
C


ATOM
10975
CB
ALA
B
160
65.405
49.946
−27.866
1.00
17.19
B
C


ATOM
10979
C
ALA
B
160
65.517
48.852
−30.105
1.00
17.27
B
C


ATOM
10980
O
ALA
B
160
66.602
48.671
−30.658
1.00
17.36
B
O


ATOM
10982
N
LYS
B
161
64.534
47.955
−30.121
1.00
17.28
B
N


ATOM
10983
CA
LYS
B
161
64.679
46.673
−30.806
1.00
17.64
B
C


ATOM
10985
CB
LYS
B
161
63.488
45.756
−30.499
1.00
17.92
B
C


ATOM
10988
CG
LYS
B
161
63.630
44.332
−31.034
1.00
18.60
B
C


ATOM
10991
CD
LYS
B
161
62.821
43.311
−30.222
1.00
19.37
B
C


ATOM
10994
CE
LYS
B
161
61.331
43.648
−30.151
1.00
19.94
B
C


ATOM
10997
NZ
LYS
B
161
60.535
42.535
−29.550
1.00
19.72
B
N


ATOM
11001
C
LYS
B
161
64.827
46.884
−32.311
1.00
17.64
B
C


ATOM
11002
O
LYS
B
161
65.773
46.387
−32.921
1.00
17.55
B
O


ATOM
11004
N
VAL
B
162
63.904
47.644
−32.897
1.00
17.74
B
N


ATOM
11005
CA
VAL
B
162
63.945
47.954
−34.331
1.00
17.76
B
C


ATOM
11007
CB
VAL
B
162
62.713
48.788
−34.770
1.00
17.61
B
C


ATOM
11009
CG1
VAL
B
162
62.847
49.240
−36.220
1.00
16.32
B
C


ATOM
11013
CG2
VAL
B
162
61.435
47.983
−34.579
1.00
17.55
B
C


ATOM
11017
C
VAL
B
162
65.231
48.697
−34.713
1.00
17.95
B
C


ATOM
11018
O
VAL
B
162
65.733
48.540
−35.829
1.00
18.42
B
O


ATOM
11020
N
PHE
B
163
65.760
49.491
−33.783
1.00
17.79
B
N


ATOM
11021
CA
PHE
B
163
66.995
50.244
−34.008
1.00
17.65
B
C


ATOM
11023
CB
PHE
B
163
67.121
51.380
−32.985
1.00
17.30
B
C


ATOM
11026
CG
PHE
B
163
68.412
52.132
−33.073
1.00
15.04
B
C


ATOM
11027
CD1
PHE
B
163
68.578
53.138
−34.008
1.00
14.91
B
C


ATOM
11029
CE1
PHE
B
163
69.773
53.832
−34.095
1.00
15.53
B
C


ATOM
11031
CZ
PHE
B
163
70.819
53.520
−33.238
1.00
14.60
B
C


ATOM
11033
CE2
PHE
B
163
70.664
52.517
−32.305
1.00
13.99
B
C


ATOM
11035
CD2
PHE
B
163
69.467
51.827
−32.227
1.00
13.98
B
C


ATOM
11037
C
PHE
B
163
68.245
49.360
−33.958
1.00
18.10
B
C


ATOM
11038
O
PHE
B
163
69.188
49.574
−34.722
1.00
18.08
B
O


ATOM
11040
N
ALA
B
164
68.256
48.381
−33.055
1.00
18.58
B
N


ATOM
11041
CA
ALA
B
164
69.415
47.502
−32.882
1.00
18.87
B
C


ATOM
11043
CB
ALA
B
164
69.362
46.814
−31.532
1.00
18.67
B
C


ATOM
11047
C
ALA
B
164
69.499
46.467
−33.999
1.00
19.36
B
C


ATOM
11048
O
ALA
B
164
70.548
46.304
−34.616
1.00
19.42
B
O


ATOM
11050
N
ILE
B
165
68.386
45.783
−34.258
1.00
20.22
B
N


ATOM
11051
CA
ILE
B
165
68.322
44.739
−35.290
1.00
20.91
B
C


ATOM
11053
CB
ILE
B
165
66.900
44.120
−35.396
1.00
21.06
B
C


ATOM
11055
CG1
ILE
B
165
66.529
43.370
−34.114
1.00
20.91
B
C


ATOM
11058
CD1
ILE
B
165
65.107
42.851
−34.110
1.00
21.56
B
C


ATOM
11062
CG2
ILE
B
165
66.810
43.158
−36.577
1.00
21.26
B
C


ATOM
11066
C
ILE
B
165
68.732
45.267
−36.668
1.00
21.49
B
C


ATOM
11067
O
ILE
B
165
69.319
44.533
−37.466
1.00
21.69
B
O


ATOM
11069
N
SER
B
166
68.419
46.533
−36.941
1.00
22.01
B
N


ATOM
11070
CA
SER
B
166
68.784
47.169
−38.210
1.00
22.52
B
C


ATOM
11072
CB
SER
B
166
68.144
48.560
−38.322
1.00
22.55
B
C


ATOM
11075
OG
SER
B
166
68.720
49.477
−37.407
1.00
22.35
B
O


ATOM
11077
C
SER
B
166
70.302
47.274
−38.410
1.00
23.00
B
C


ATOM
11078
O
SER
B
166
70.782
47.188
−39.542
1.00
23.31
B
O


ATOM
11080
N
HIS
B
167
71.044
47.460
−37.317
1.00
23.34
B
N


ATOM
11081
CA
HIS
B
167
72.509
47.582
−37.372
1.00
23.44
B
C


ATOM
11083
CB
HIS
B
167
73.004
48.652
−36.387
1.00
23.48
B
C


ATOM
11086
CG
HIS
B
167
72.718
50.058
−36.822
1.00
24.37
B
C


ATOM
11087
ND1
HIS
B
167
72.058
50.966
−36.022
1.00
24.84
B
N


ATOM
11089
CE1
HIS
B
167
71.949
52.117
−36.661
1.00
24.23
B
C


ATOM
11091
NE2
HIS
B
167
72.513
51.988
−37.849
1.00
24.82
B
N


ATOM
11093
CD2
HIS
B
167
73.001
50.710
−37.974
1.00
25.08
B
C


ATOM
11095
C
HIS
B
167
73.244
46.264
−37.103
1.00
23.24
B
C


ATOM
11096
O
HIS
B
167
74.377
46.095
−37.546
1.00
23.60
B
O


ATOM
11098
N
LEU
B
168
72.605
45.340
−36.387
1.00
22.97
B
N


ATOM
11099
CA
LEU
B
168
73.255
44.091
−35.967
1.00
22.95
B
C


ATOM
11101
CB
LEU
B
168
72.449
43.412
−34.852
1.00
22.93
B
C


ATOM
11104
CG
LEU
B
168
72.509
44.048
−33.460
1.00
22.05
B
C


ATOM
11106
CD1
LEU
B
168
71.330
43.587
−32.619
1.00
20.71
B
C


ATOM
11110
CD2
LEU
B
168
73.827
43.733
−32.766
1.00
20.14
B
C


ATOM
11114
C
LEU
B
168
73.462
43.089
−37.103
1.00
23.36
B
C


ATOM
11115
O
LEU
B
168
74.549
42.531
−37.249
1.00
23.26
B
O


ATOM
11117
N
LYS
B
169
72.418
42.855
−37.893
1.00
24.10
B
N


ATOM
11118
CA
LYS
B
169
72.433
41.778
−38.892
1.00
24.87
B
C


ATOM
11120
CB
LYS
B
169
71.002
41.350
−39.249
1.00
24.93
B
C


ATOM
11123
CG
LYS
B
169
70.192
42.360
−40.059
1.00
25.82
B
C


ATOM
11126
CD
LYS
B
169
68.686
42.102
−39.943
1.00
27.02
B
C


ATOM
11129
CE
LYS
B
169
68.291
40.714
−40.452
1.00
27.94
B
C


ATOM
11132
NZ
LYS
B
169
66.823
40.466
−40.352
1.00
27.64
B
N


ATOM
11136
C
LYS
B
169
73.231
42.100
−40.161
1.00
25.51
B
C


ATOM
11137
O
LYS
B
169
73.547
41.195
−40.937
1.00
25.25
B
O


ATOM
11139
N
GLU
B
170
73.564
43.376
−40.361
1.00
26.58
B
N


ATOM
11140
CA
GLU
B
170
74.350
43.809
−41.523
1.00
27.53
B
C


ATOM
11142
CB
GLU
B
170
73.806
45.137
−42.080
1.00
27.70
B
C


ATOM
11145
CG
GLU
B
170
72.272
45.219
−42.233
1.00
29.32
B
C


ATOM
11148
CD
GLU
B
170
71.704
44.349
−43.355
1.00
30.04
B
C


ATOM
11149
OE1
GLU
B
170
72.480
43.674
−44.065
1.00
31.89
B
O


ATOM
11150
OE2
GLU
B
170
70.467
44.347
−43.530
1.00
28.58
B
O


ATOM
11151
C
GLU
B
170
75.843
43.964
−41.181
1.00
27.95
B
C


ATOM
11152
O
GLU
B
170
76.540
44.784
−41.792
1.00
28.24
B
O


ATOM
11154
N
LEU
B
171
76.326
43.173
−40.217
1.00
27.99
B
N


ATOM
11155
CA
LEU
B
171
77.729
43.208
−39.791
1.00
27.86
B
C


ATOM
11157
CB
LEU
B
171
77.830
43.290
−38.264
1.00
27.64
B
C


ATOM
11160
CG
LEU
B
171
77.203
44.514
−37.588
1.00
26.91
B
C


ATOM
11162
CD1
LEU
B
171
77.470
44.483
−36.088
1.00
24.62
B
C


ATOM
11166
CD2
LEU
B
171
77.709
45.818
−38.197
1.00
25.86
B
C


ATOM
11170
C
LEU
B
171
78.485
41.976
−40.283
1.00
28.06
B
C


ATOM
11171
O
LEU
B
171
77.922
40.882
−40.362
1.00
27.83
B
O


ATOM
11173
N
SER
B
172
79.766
42.166
−40.595
1.00
28.45
B
N


ATOM
11174
CA
SER
B
172
80.616
41.104
−41.136
1.00
28.64
B
C


ATOM
11176
CB
SER
B
172
81.520
41.664
−42.237
1.00
28.62
B
C


ATOM
11179
OG
SER
B
172
82.445
40.690
−42.689
1.00
28.34
B
O


ATOM
11181
C
SER
B
172
81.476
40.461
−40.051
1.00
28.97
B
C


ATOM
11182
O
SER
B
172
81.869
41.120
−39.084
1.00
28.98
B
O


ATOM
11184
N
GLU
B
173
81.778
39.176
−40.232
1.00
29.33
B
N


ATOM
11185
CA
GLU
B
173
82.661
38.439
−39.323
1.00
29.65
B
C


ATOM
11187
CB
GLU
B
173
82.531
36.925
−39.553
1.00
29.65
B
C


ATOM
11190
CG
GLU
B
173
83.188
36.059
−38.471
1.00
30.47
B
C


ATOM
11193
CD
GLU
B
173
82.816
34.585
−38.567
1.00
31.62
B
C


ATOM
11194
OE1
GLU
B
173
81.610
34.271
−38.670
1.00
31.50
B
O


ATOM
11195
OE2
GLU
B
173
83.732
33.735
−38.523
1.00
31.84
B
O


ATOM
11196
C
GLU
B
173
84.126
38.882
−39.464
1.00
29.86
B
C


ATOM
11197
O
GLU
B
173
84.962
38.534
−38.630
1.00
30.01
B
O


ATOM
11199
N
GLU
B
174
84.435
39.639
−40.518
1.00
29.81
B
N


ATOM
11200
CA
GLU
B
174
85.760
40.244
−40.676
1.00
29.91
B
C


ATOM
11202
CB
GLU
B
174
86.107
40.423
−42.160
1.00
30.15
B
C


ATOM
11205
CG
GLU
B
174
86.698
39.179
−42.809
1.00
30.29
B
C


ATOM
11208
CD
GLU
B
174
86.767
39.283
−44.321
1.00
29.90
B
C


ATOM
11209
OE1
GLU
B
174
87.889
39.316
−44.868
1.00
29.26
B
O


ATOM
11210
OE2
GLU
B
174
85.697
39.339
−44.962
1.00
29.35
B
O


ATOM
11211
C
GLU
B
174
85.855
41.587
−39.950
1.00
29.71
B
C


ATOM
11212
O
GLU
B
174
86.787
41.810
−39.175
1.00
29.67
B
O


ATOM
11214
N
LYS
B
175
84.891
42.473
−40.205
1.00
29.47
B
N


ATOM
11215
CA
LYS
B
175
84.867
43.811
−39.595
1.00
29.30
B
C


ATOM
11217
CB
LYS
B
175
83.570
44.546
−39.944
1.00
29.60
B
C


ATOM
11220
CG
LYS
B
175
83.454
44.992
−41.390
1.00
30.58
B
C


ATOM
11223
CD
LYS
B
175
82.079
45.598
−41.651
1.00
31.84
B
C


ATOM
11226
CE
LYS
B
175
81.816
45.781
−43.136
1.00
32.09
B
C


ATOM
11229
NZ
LYS
B
175
80.394
46.124
−43.416
1.00
32.12
B
N


ATOM
11233
C
LYS
B
175
85.001
43.754
−38.076
1.00
28.77
B
C


ATOM
11234
O
LYS
B
175
85.642
44.612
−37.470
1.00
28.82
B
O


ATOM
11236
N
ILE
B
176
84.375
42.745
−37.476
1.00
28.19
B
N


ATOM
11237
CA
ILE
B
176
84.444
42.513
−36.034
1.00
27.82
B
C


ATOM
11239
CB
ILE
B
176
83.105
42.841
−35.331
1.00
27.95
B
C


ATOM
11241
CG1
ILE
B
176
81.911
42.300
−36.132
1.00
27.44
B
C


ATOM
11244
CD1
ILE
B
176
80.584
42.443
−35.424
1.00
26.82
B
C


ATOM
11248
CG2
ILE
B
176
82.971
44.346
−35.137
1.00
28.50
B
C


ATOM
11252
C
ILE
B
176
84.834
41.061
−35.777
1.00
27.40
B
C


ATOM
11253
O
ILE
B
176
84.754
40.227
−36.675
1.00
27.29
B
O


ATOM
11255
N
GLY
B
177
85.249
40.767
−34.548
1.00
26.94
B
N


ATOM
11256
CA
GLY
B
177
85.791
39.452
−34.203
1.00
26.74
B
C


ATOM
11259
C
GLY
B
177
84.867
38.276
−34.467
1.00
26.46
B
C


ATOM
11260
O
GLY
B
177
83.648
38.434
−34.540
1.00
26.73
B
O


ATOM
11262
N
LYS
B
178
85.461
37.094
−34.618
1.00
26.15
B
N


ATOM
11263
CA
LYS
B
178
84.706
35.851
−34.767
1.00
25.92
B
C


ATOM
11265
CB
LYS
B
178
85.657
34.667
−34.967
1.00
25.77
B
C


ATOM
11268
CG
LYS
B
178
84.967
33.322
−35.183
1.00
25.80
B
C


ATOM
11271
CD
LYS
B
178
85.979
32.189
−35.296
1.00
25.76
B
C


ATOM
11274
CE
LYS
B
178
85.347
30.924
−35.863
1.00
25.07
B
C


ATOM
11277
NZ
LYS
B
178
86.333
29.818
−35.998
1.00
23.38
B
N


ATOM
11281
C
LYS
B
178
83.832
35.609
−33.538
1.00
26.02
B
C


ATOM
11282
O
LYS
B
178
82.671
35.214
−33.667
1.00
26.16
B
O


ATOM
11284
N
GLU
B
179
84.393
35.850
−32.353
1.00
25.87
B
N


ATOM
11285
CA
GLU
B
179
83.658
35.649
−31.099
1.00
25.72
B
C


ATOM
11287
CB
GLU
B
179
84.603
35.673
−29.881
1.00
25.81
B
C


ATOM
11290
CG
GLU
B
179
85.277
37.014
−29.571
1.00
26.23
B
C


ATOM
11293
CD
GLU
B
179
86.166
36.951
−28.330
1.00
26.14
B
C


ATOM
11294
OE1
GLU
B
179
86.250
37.961
−27.601
1.00
25.98
B
O


ATOM
11295
OE2
GLU
B
179
86.780
35.892
−28.077
1.00
25.53
B
O


ATOM
11296
C
GLU
B
179
82.509
36.649
−30.932
1.00
25.07
B
C


ATOM
11297
O
GLU
B
179
81.457
36.298
−30.397
1.00
24.79
B
O


ATOM
11299
N
LEU
B
180
82.712
37.881
−31.401
1.00
24.36
B
N


ATOM
11300
CA
LEU
B
180
81.663
38.904
−31.370
1.00
23.69
B
C


ATOM
11302
CB
LEU
B
180
82.253
40.300
−31.611
1.00
23.71
B
C


ATOM
11305
CG
LEU
B
180
81.387
41.489
−31.175
1.00
23.25
B
C


ATOM
11307
CD1
LEU
B
180
81.356
41.608
−29.657
1.00
22.05
B
C


ATOM
11311
CD2
LEU
B
180
81.892
42.785
−31.800
1.00
22.07
B
C


ATOM
11315
C
LEU
B
180
80.578
38.604
−32.407
1.00
23.13
B
C


ATOM
11316
O
LEU
B
180
79.404
38.903
−32.187
1.00
22.94
B
O


ATOM
11318
N
ALA
B
181
80.980
38.015
−33.533
1.00
22.63
B
N


ATOM
11319
CA
ALA
B
181
80.039
37.593
−34.573
1.00
22.38
B
C


ATOM
11321
CB
ALA
B
181
80.792
37.158
−35.819
1.00
22.13
B
C


ATOM
11325
C
ALA
B
181
79.138
36.459
−34.083
1.00
22.21
B
C


ATOM
11326
O
ALA
B
181
77.935
36.451
−34.347
1.00
22.14
B
O


ATOM
11328
N
GLU
B
182
79.732
35.506
−33.371
1.00
21.95
B
N


ATOM
11329
CA
GLU
B
182
79.000
34.349
−32.857
1.00
21.66
B
C


ATOM
11331
CB
GLU
B
182
79.979
33.284
−32.350
1.00
21.93
B
C


ATOM
11334
CG
GLU
B
182
80.709
32.557
−33.481
1.00
22.98
B
C


ATOM
11337
CD
GLU
B
182
81.913
31.751
−33.016
1.00
23.56
B
C


ATOM
11338
OE1
GLU
B
182
82.298
31.861
−31.831
1.00
23.87
B
O


ATOM
11339
OE2
GLU
B
182
82.477
31.005
−33.847
1.00
22.99
B
O


ATOM
11340
C
GLU
B
182
78.003
34.731
−31.762
1.00
20.94
B
C


ATOM
11341
O
GLU
B
182
76.949
34.107
−31.643
1.00
20.76
B
O


ATOM
11343
N
GLN
B
183
78.334
35.750
−30.972
1.00
20.28
B
N


ATOM
11344
CA
GLN
B
183
77.412
36.262
−29.957
1.00
20.01
B
C


ATOM
11346
CB
GLN
B
183
78.130
37.187
−28.968
1.00
19.95
B
C


ATOM
11349
CG
GLN
B
183
79.140
36.483
−28.068
1.00
20.86
B
C


ATOM
11352
CD
GLN
B
183
79.118
37.001
−26.638
1.00
22.16
B
C


ATOM
11353
OE1
GLN
B
183
79.484
38.147
−26.375
1.00
22.85
B
O


ATOM
11354
NE2
GLN
B
183
78.689
36.153
−25.707
1.00
21.77
B
N


ATOM
11357
C
GLN
B
183
76.234
36.999
−30.591
1.00
19.93
B
C


ATOM
11358
O
GLN
B
183
75.125
36.978
−30.052
1.00
19.93
B
O


ATOM
11360
N
VAL
B
184
76.477
37.651
−31.727
1.00
19.67
B
N


ATOM
11361
CA
VAL
B
184
75.416
38.334
−32.469
1.00
19.49
B
C


ATOM
11363
CB
VAL
B
184
75.991
39.266
−33.553
1.00
19.50
B
C


ATOM
11365
CG1
VAL
B
184
76.767
40.403
−32.906
1.00
19.63
B
C


ATOM
11369
CG2
VAL
B
184
74.880
39.815
−34.440
1.00
19.00
B
C


ATOM
11373
C
VAL
B
184
74.464
37.325
−33.111
1.00
19.48
B
C


ATOM
11374
O
VAL
B
184
73.246
37.484
−33.036
1.00
19.34
B
O


ATOM
11376
N
ASN
B
185
75.027
36.289
−33.732
1.00
19.56
B
N


ATOM
11377
CA
ASN
B
185
74.230
35.210
−34.323
1.00
19.71
B
C


ATOM
11379
CB
ASN
B
185
75.115
34.272
−35.153
1.00
19.76
B
C


ATOM
11382
CG
ASN
B
185
75.756
34.965
−36.348
1.00
20.50
B
C


ATOM
11383
OD1
ASN
B
185
75.392
36.085
−36.706
1.00
22.61
B
O


ATOM
11384
ND2
ASN
B
185
76.719
34.295
−36.971
1.00
21.21
B
N


ATOM
11387
C
ASN
B
185
73.473
34.402
−33.266
1.00
19.77
B
C


ATOM
11388
O
ASN
B
185
72.386
33.891
−33.533
1.00
20.02
B
O


ATOM
11390
N
HIS
B
186
74.057
34.287
−32.075
1.00
19.72
B
N


ATOM
11391
CA
HIS
B
186
73.404
33.628
−30.942
1.00
19.80
B
C


ATOM
11393
CB
HIS
B
186
74.414
33.411
−29.808
1.00
19.92
B
C


ATOM
11396
CG
HIS
B
186
73.854
32.703
−28.611
1.00
19.22
B
C


ATOM
11397
ND1
HIS
B
186
73.549
31.358
−28.615
1.00
19.55
B
N


ATOM
11399
CE1
HIS
B
186
73.091
31.010
−27.426
1.00
18.27
B
C


ATOM
11401
NE2
HIS
B
186
73.093
32.077
−26.649
1.00
18.30
B
N


ATOM
11403
CD2
HIS
B
186
73.571
33.149
−27.364
1.00
18.39
B
C


ATOM
11405
C
HIS
B
186
72.225
34.464
−30.448
1.00
19.84
B
C


ATOM
11406
O
HIS
B
186
71.124
33.943
−30.269
1.00
19.69
B
O


ATOM
11408
N
ALA
B
187
72.463
35.758
−30.240
1.00
19.89
B
N


ATOM
11409
CA
ALA
B
187
71.419
36.682
−29.780
1.00
19.70
B
C


ATOM
11411
CB
ALA
B
187
72.029
38.022
−29.387
1.00
19.58
B
C


ATOM
11415
C
ALA
B
187
70.320
36.886
−30.829
1.00
19.42
B
C


ATOM
11416
O
ALA
B
187
69.152
37.071
−30.477
1.00
19.51
B
O


ATOM
11418
N
LEU
B
188
70.693
36.853
−32.109
1.00
18.76
B
N


ATOM
11419
CA
LEU
B
188
69.721
36.993
−33.200
1.00
18.16
B
C


ATOM
11421
CB
LEU
B
188
70.409
37.449
−34.492
1.00
17.88
B
C


ATOM
11424
CG
LEU
B
188
70.820
38.925
−34.496
1.00
17.28
B
C


ATOM
11426
CD1
LEU
B
188
71.831
39.217
−35.593
1.00
16.54
B
C


ATOM
11430
CD2
LEU
B
188
69.600
39.820
−34.640
1.00
15.64
B
C


ATOM
11434
C
LEU
B
188
68.916
35.711
−33.436
1.00
17.88
B
C


ATOM
11435
O
LEU
B
188
67.764
35.775
−33.863
1.00
18.07
B
O


ATOM
11437
N
GLU
B
189
69.518
34.554
−33.164
1.00
17.45
B
N


ATOM
11438
CA
GLU
B
189
68.783
33.286
−33.161
1.00
17.00
B
C


ATOM
11440
CB
GLU
B
189
69.717
32.116
−32.830
1.00
16.79
B
C


ATOM
11443
CG
GLU
B
189
69.039
30.745
−32.807
1.00
16.46
B
C


ATOM
11446
CD
GLU
B
189
70.001
29.608
−32.506
1.00
16.49
B
C


ATOM
11447
OE1
GLU
B
189
70.952
29.810
−31.720
1.00
17.45
B
O


ATOM
11448
OE2
GLU
B
189
69.802
28.502
−33.051
1.00
16.29
B
O


ATOM
11449
C
GLU
B
189
67.647
33.354
−32.141
1.00
16.85
B
C


ATOM
11450
O
GLU
B
189
66.513
32.963
−32.430
1.00
16.54
B
O


ATOM
11452
N
LEU
B
190
67.973
33.852
−30.949
1.00
16.84
B
N


ATOM
11453
CA
LEU
B
190
67.008
34.033
−29.864
1.00
16.87
B
C


ATOM
11455
CB
LEU
B
190
66.646
32.680
−29.242
1.00
16.90
B
C


ATOM
11458
CG
LEU
B
190
65.420
32.614
−28.326
1.00
16.89
B
C


ATOM
11460
CD1
LEU
B
190
64.144
32.781
−29.127
1.00
16.28
B
C


ATOM
11464
CD2
LEU
B
190
65.395
31.296
−27.566
1.00
17.45
B
C


ATOM
11468
C
LEU
B
190
67.637
34.940
−28.801
1.00
16.77
B
C


ATOM
11469
O
LEU
B
190
68.826
34.803
−28.509
1.00
17.14
B
O


ATOM
11471
N
PRO
B
191
66.857
35.873
−28.222
1.00
16.38
B
N


ATOM
11472
CA
PRO
B
191
67.420
36.724
−27.166
1.00
16.04
B
C


ATOM
11474
CB
PRO
B
191
66.391
37.848
−27.040
1.00
15.95
B
C


ATOM
11477
CG
PRO
B
191
65.114
37.221
−27.453
1.00
16.28
B
C


ATOM
11480
CD
PRO
B
191
65.460
36.231
−28.527
1.00
16.22
B
C


ATOM
11483
C
PRO
B
191
67.576
35.981
−25.838
1.00
15.62
B
C


ATOM
11484
O
PRO
B
191
67.046
34.884
−25.682
1.00
15.70
B
O


ATOM
11485
N
LEU
B
192
68.303
36.578
−24.896
1.00
15.37
B
N


ATOM
11486
CA
LEU
B
192
68.515
35.973
−23.578
1.00
14.71
B
C


ATOM
11488
CB
LEU
B
192
69.477
36.810
−22.735
1.00
14.48
B
C


ATOM
11491
CG
LEU
B
192
70.931
36.828
−23.194
1.00
14.76
B
C


ATOM
11493
CD1
LEU
B
192
71.650
38.005
−22.575
1.00
16.74
B
C


ATOM
11497
CD2
LEU
B
192
71.627
35.526
−22.840
1.00
14.51
B
C


ATOM
11501
C
LEU
B
192
67.203
35.839
−22.833
1.00
14.18
B
C


ATOM
11502
O
LEU
B
192
66.930
34.801
−22.234
1.00
14.39
B
O


ATOM
11504
N
HIS
B
193
66.388
36.889
−22.891
1.00
13.57
B
N


ATOM
11505
CA
HIS
B
193
65.119
36.926
−22.170
1.00
13.63
B
C


ATOM
11507
CB
HIS
B
193
64.446
38.292
−22.363
1.00
13.58
B
C


ATOM
11510
CG
HIS
B
193
63.202
38.477
−21.548
1.00
13.03
B
C


ATOM
11511
ND1
HIS
B
193
63.208
38.485
−20.170
1.00
13.37
B
N


ATOM
11513
CE1
HIS
B
193
61.976
38.662
−19.727
1.00
13.22
B
C


ATOM
11515
NE2
HIS
B
193
61.171
38.773
−20.769
1.00
11.40
B
N


ATOM
11517
CD2
HIS
B
193
61.913
38.661
−21.920
1.00
11.23
B
C


ATOM
11519
C
HIS
B
193
64.160
35.795
−22.570
1.00
13.78
B
C


ATOM
11520
O
HIS
B
193
63.257
35.440
−21.802
1.00
13.38
B
O


ATOM
11522
N
ARG
B
194
64.365
35.224
−23.756
1.00
14.17
B
N


ATOM
11523
CA
ARG
B
194
63.487
34.175
−24.273
1.00
14.88
B
C


ATOM
11525
CB
ARG
B
194
62.992
34.567
−25.663
1.00
15.05
B
C


ATOM
11528
CG
ARG
B
194
62.208
35.872
−25.689
1.00
16.31
B
C


ATOM
11531
CD
ARG
B
194
61.684
36.153
−27.083
1.00
18.23
B
C


ATOM
11534
NE
ARG
B
194
60.754
37.277
−27.116
1.00
18.82
B
N


ATOM
11536
CZ
ARG
B
194
60.060
37.648
−28.190
1.00
18.69
B
C


ATOM
11537
NH1
ARG
B
194
60.186
36.987
−29.338
1.00
19.08
B
N


ATOM
11540
NH2
ARG
B
194
59.235
38.687
−28.117
1.00
19.19
B
N


ATOM
11543
C
ARG
B
194
64.126
32.785
−24.336
1.00
14.83
B
C


ATOM
11544
O
ARG
B
194
63.439
31.814
−24.648
1.00
15.42
B
O


ATOM
11546
N
ARG
B
195
65.421
32.681
−24.042
1.00
14.50
B
N


ATOM
11547
CA
ARG
B
195
66.118
31.398
−24.116
1.00
14.49
B
C


ATOM
11549
CB
ARG
B
195
67.545
31.588
−24.627
1.00
14.69
B
C


ATOM
11552
CG
ARG
B
195
68.145
30.336
−25.240
1.00
15.98
B
C


ATOM
11555
CD
ARG
B
195
69.649
30.461
−25.417
1.00
17.88
B
C


ATOM
11558
NE
ARG
B
195
70.028
31.579
−26.279
1.00
18.66
B
N


ATOM
11560
CZ
ARG
B
195
69.963
31.572
−27.610
1.00
20.86
B
C


ATOM
11561
NH1
ARG
B
195
69.522
30.505
−28.274
1.00
21.51
B
N


ATOM
11564
NH2
ARG
B
195
70.344
32.646
−28.289
1.00
22.00
B
N


ATOM
11567
C
ARG
B
195
66.141
30.733
−22.747
1.00
14.49
B
C


ATOM
11568
O
ARG
B
195
66.247
31.412
−21.723
1.00
14.49
B
O


ATOM
11570
N
THR
B
196
66.047
29.404
−22.736
1.00
14.52
B
N


ATOM
11571
CA
THR
B
196
66.036
28.641
−21.490
1.00
14.61
B
C


ATOM
11573
CB
THR
B
196
65.535
27.199
−21.701
1.00
14.72
B
C


ATOM
11575
OG1
THR
B
196
66.358
26.536
−22.668
1.00
14.27
B
O


ATOM
11577
CG2
THR
B
196
64.090
27.198
−22.178
1.00
15.09
B
C


ATOM
11581
C
THR
B
196
67.427
28.599
−20.868
1.00
14.74
B
C


ATOM
11582
O
THR
B
196
68.431
28.613
−21.577
1.00
14.94
B
O


ATOM
11584
N
GLN
B
197
67.464
28.529
−19.540
1.00
14.94
B
N


ATOM
11585
CA
GLN
B
197
68.707
28.631
−18.768
1.00
14.89
B
C


ATOM
11587
CB
GLN
B
197
68.415
28.398
−17.273
1.00
14.86
B
C


ATOM
11590
CG
GLN
B
197
69.335
29.146
−16.312
1.00
13.67
B
C


ATOM
11593
CD
GLN
B
197
70.536
28.336
−15.866
1.00
11.84
B
C


ATOM
11594
OE1
GLN
B
197
71.150
27.618
−16.653
1.00
11.73
B
O


ATOM
11595
NE2
GLN
B
197
70.885
28.460
−14.596
1.00
10.93
B
N


ATOM
11598
C
GLN
B
197
69.785
27.656
−19.250
1.00
15.04
B
C


ATOM
11599
O
GLN
B
197
70.916
28.058
−19.533
1.00
14.84
B
O


ATOM
11601
N
ARG
B
198
69.421
26.380
−19.353
1.00
15.25
B
N


ATOM
11602
CA
ARG
B
198
70.382
25.316
−19.657
1.00
15.00
B
C


ATOM
11604
CB
ARG
B
198
69.755
23.946
−19.396
1.00
14.97
B
C


ATOM
11607
CG
ARG
B
198
69.439
23.673
−17.932
1.00
15.36
B
C


ATOM
11610
CD
ARG
B
198
70.675
23.289
−17.132
1.00
15.24
B
C


ATOM
11613
NE
ARG
B
198
71.376
24.438
−16.564
1.00
15.04
B
N


ATOM
11615
CZ
ARG
B
198
72.401
24.347
−15.717
1.00
15.93
B
C


ATOM
11616
NH1
ARG
B
198
72.855
23.160
−15.334
1.00
16.51
B
N


ATOM
11619
NH2
ARG
B
198
72.977
25.447
−15.248
1.00
16.24
B
N


ATOM
11622
C
ARG
B
198
70.916
25.373
−21.086
1.00
14.67
B
C


ATOM
11623
O
ARG
B
198
72.093
25.083
−21.320
1.00
14.37
B
O


ATOM
11625
N
LEU
B
199
70.055
25.726
−22.038
1.00
14.51
B
N


ATOM
11626
CA
LEU
B
199
70.490
25.910
−23.427
1.00
14.52
B
C


ATOM
11628
CB
LEU
B
199
69.297
26.133
−24.378
1.00
14.65
B
C


ATOM
11631
CG
LEU
B
199
68.606
24.925
−25.037
1.00
14.01
B
C


ATOM
11633
CD1
LEU
B
199
67.687
24.176
−24.064
1.00
13.56
B
C


ATOM
11637
CD2
LEU
B
199
69.625
23.978
−25.659
1.00
12.13
B
C


ATOM
11641
C
LEU
B
199
71.458
27.091
−23.512
1.00
14.39
B
C


ATOM
11642
O
LEU
B
199
72.476
27.022
−24.207
1.00
14.42
B
O


ATOM
11644
N
GLU
B
200
71.132
28.168
−22.800
1.00
13.72
B
N


ATOM
11645
CA
GLU
B
200
71.998
29.335
−22.737
1.00
13.37
B
C


ATOM
11647
CB
GLU
B
200
71.312
30.473
−21.969
1.00
13.42
B
C


ATOM
11650
CG
GLU
B
200
72.160
31.723
−21.776
1.00
13.45
B
C


ATOM
11653
CD
GLU
B
200
72.875
32.157
−23.042
1.00
14.44
B
C


ATOM
11654
OE1
GLU
B
200
72.268
32.095
−24.133
1.00
14.98
B
O


ATOM
11655
OE2
GLU
B
200
74.049
32.561
−22.945
1.00
15.44
B
O


ATOM
11656
C
GLU
B
200
73.317
28.968
−22.071
1.00
13.44
B
C


ATOM
11657
O
GLU
B
200
74.389
29.324
−22.561
1.00
13.42
B
O


ATOM
11659
N
ALA
B
201
73.229
28.248
−20.959
1.00
13.64
B
N


ATOM
11660
CA
ALA
B
201
74.414
27.828
−20.222
1.00
14.07
B
C


ATOM
11662
CB
ALA
B
201
74.017
27.028
−18.991
1.00
14.39
B
C


ATOM
11666
C
ALA
B
201
75.371
27.018
−21.094
1.00
14.43
B
C


ATOM
11667
O
ALA
B
201
76.564
27.319
−21.144
1.00
14.77
B
O


ATOM
11669
N
VAL
B
202
74.849
26.008
−21.791
1.00
14.63
B
N


ATOM
11670
CA
VAL
B
202
75.691
25.119
−22.602
1.00
14.73
B
C


ATOM
11672
CB
VAL
B
202
74.885
23.939
−23.206
1.00
14.72
B
C


ATOM
11674
CG1
VAL
B
202
73.980
24.415
−24.333
1.00
15.60
B
C


ATOM
11678
CG2
VAL
B
202
75.828
22.852
−23.706
1.00
13.72
B
C


ATOM
11682
C
VAL
B
202
76.425
25.865
−23.723
1.00
14.67
B
C


ATOM
11683
O
VAL
B
202
77.535
25.484
−24.101
1.00
14.54
B
O


ATOM
11685
N
TRP
B
203
75.809
26.926
−24.238
1.00
14.66
B
N


ATOM
11686
CA
TRP
B
203
76.417
27.728
−25.295
1.00
14.84
B
C


ATOM
11688
CB
TRP
B
203
75.344
28.484
−26.083
1.00
14.97
B
C


ATOM
11691
CG
TRP
B
203
75.916
29.258
−27.217
1.00
14.08
B
C


ATOM
11692
CD1
TRP
B
203
76.114
28.818
−28.491
1.00
13.97
B
C


ATOM
11694
NE1
TRP
B
203
76.677
29.812
−29.251
1.00
14.19
B
N


ATOM
11696
CE2
TRP
B
203
76.860
30.919
−28.465
1.00
13.10
B
C


ATOM
11697
CD2
TRP
B
203
76.393
30.603
−27.176
1.00
12.77
B
C


ATOM
11698
CE3
TRP
B
203
76.465
31.575
−26.173
1.00
13.68
B
C


ATOM
11700
CZ3
TRP
B
203
76.993
32.812
−26.486
1.00
14.21
B
C


ATOM
11702
CH2
TRP
B
203
77.449
33.096
−27.778
1.00
14.39
B
C


ATOM
11704
CZ2
TRP
B
203
77.393
32.165
−28.779
1.00
13.69
B
C


ATOM
11706
C
TRP
B
203
77.438
28.722
−24.739
1.00
15.07
B
C


ATOM
11707
O
TRP
B
203
78.578
28.779
−25.211
1.00
15.56
B
O


ATOM
11709
N
SER
B
204
77.018
29.507
−23.749
1.00
14.73
B
N


ATOM
11710
CA
SER
B
204
77.861
30.563
−23.179
1.00
14.32
B
C


ATOM
11712
CB
SER
B
204
77.084
31.382
−22.146
1.00
14.36
B
C


ATOM
11715
OG
SER
B
204
76.240
32.322
−22.781
1.00
13.68
B
O


ATOM
11717
C
SER
B
204
79.149
30.044
−22.549
1.00
14.07
B
C


ATOM
11718
O
SER
B
204
80.164
30.735
−22.583
1.00
14.22
B
O


ATOM
11720
N
ILE
B
205
79.103
28.840
−21.976
1.00
13.65
B
N


ATOM
11721
CA
ILE
B
205
80.286
28.223
−21.365
1.00
13.54
B
C


ATOM
11723
CB
ILE
B
205
79.918
26.963
−20.542
1.00
13.39
B
C


ATOM
11725
CG1
ILE
B
205
79.225
27.367
−19.241
1.00
13.19
B
C


ATOM
11728
CD1
ILE
B
205
78.813
26.197
−18.372
1.00
13.69
B
C


ATOM
11732
CG2
ILE
B
205
81.162
26.151
−20.208
1.00
13.60
B
C


ATOM
11736
C
ILE
B
205
81.352
27.870
−22.410
1.00
13.51
B
C


ATOM
11737
O
ILE
B
205
82.542
28.105
−22.193
1.00
12.96
B
O


ATOM
11739
N
GLU
B
206
80.918
27.309
−23.536
1.00
13.71
B
N


ATOM
11740
CA
GLU
B
206
81.822
26.989
−24.640
1.00
13.71
B
C


ATOM
11742
CB
GLU
B
206
81.084
26.164
−25.706
1.00
13.88
B
C


ATOM
11745
CG
GLU
B
206
81.888
25.840
−26.973
1.00
15.04
B
C


ATOM
11748
CD
GLU
B
206
83.222
25.163
−26.693
1.00
15.38
B
C


ATOM
11749
OE1
GLU
B
206
83.322
24.405
−25.704
1.00
15.76
B
O


ATOM
11750
OE2
GLU
B
206
84.172
25.387
−27.474
1.00
15.99
B
O


ATOM
11751
C
GLU
B
206
82.418
28.263
−25.253
1.00
13.41
B
C


ATOM
11752
O
GLU
B
206
83.603
28.303
−25.581
1.00
12.99
B
O


ATOM
11754
N
ALA
B
207
81.592
29.297
−25.397
1.00
13.13
B
N


ATOM
11755
CA
ALA
B
207
82.037
30.583
−25.938
1.00
12.74
B
C


ATOM
11757
CB
ALA
B
207
80.834
31.472
−26.228
1.00
12.73
B
C


ATOM
11761
C
ALA
B
207
83.008
31.300
−24.997
1.00
12.41
B
C


ATOM
11762
O
ALA
B
207
84.012
31.856
−25.441
1.00
11.95
B
O


ATOM
11764
N
TYR
B
208
82.695
31.283
−23.702
1.00
12.40
B
N


ATOM
11765
CA
TYR
B
208
83.506
31.947
−22.674
1.00
12.38
B
C


ATOM
11767
CB
TYR
B
208
82.719
32.017
−21.359
1.00
12.14
B
C


ATOM
11770
CG
TYR
B
208
83.307
32.930
−20.307
1.00
11.69
B
C


ATOM
11771
CD1
TYR
B
208
83.112
34.307
−20.366
1.00
12.57
B
C


ATOM
11773
CE1
TYR
B
208
83.640
35.152
−19.398
1.00
13.17
B
C


ATOM
11775
CZ
TYR
B
208
84.367
34.620
−18.349
1.00
13.50
B
C


ATOM
11776
OH
TYR
B
208
84.891
35.454
−17.388
1.00
14.79
B
O


ATOM
11778
CE2
TYR
B
208
84.568
33.254
−18.262
1.00
12.55
B
C


ATOM
11780
CD2
TYR
B
208
84.035
32.417
−19.238
1.00
11.68
B
C


ATOM
11782
C
TYR
B
208
84.834
31.221
−22.450
1.00
12.66
B
C


ATOM
11783
O
TYR
B
208
85.840
31.841
−22.109
1.00
12.19
B
O


ATOM
11785
N
ARG
B
209
84.818
29.904
−22.637
1.00
13.27
B
N


ATOM
11786
CA
ARG
B
209
86.020
29.073
−22.563
1.00
13.72
B
C


ATOM
11788
CB
ARG
B
209
85.627
27.607
−22.794
1.00
13.38
B
C


ATOM
11791
CG
ARG
B
209
86.776
26.618
−22.939
1.00
13.64
B
C


ATOM
11794
CD
ARG
B
209
86.308
25.339
−23.618
1.00
12.76
B
C


ATOM
11797
NE
ARG
B
209
85.380
24.576
−22.789
1.00
8.75
B
N


ATOM
11799
CZ
ARG
B
209
85.737
23.800
−21.769
1.00
7.83
B
C


ATOM
11800
NH1
ARG
B
209
87.014
23.671
−21.418
1.00
7.53
B
N


ATOM
11803
NH2
ARG
B
209
84.805
23.149
−21.088
1.00
9.72
B
N


ATOM
11806
C
ARG
B
209
87.091
29.520
−23.574
1.00
14.74
B
C


ATOM
11807
O
ARG
B
209
88.291
29.385
−23.317
1.00
14.87
B
O


ATOM
11809
N
LYS
B
210
86.653
30.052
−24.715
1.00
15.63
B
N


ATOM
11810
CA
LYS
B
210
87.566
30.517
−25.763
1.00
16.08
B
C


ATOM
11812
CB
LYS
B
210
86.837
30.620
−27.106
1.00
16.07
B
C


ATOM
11815
CG
LYS
B
210
86.325
29.290
−27.644
1.00
16.25
B
C


ATOM
11818
CD
LYS
B
210
85.403
29.498
−28.838
1.00
15.92
B
C


ATOM
11821
CE
LYS
B
210
84.773
28.196
−29.298
1.00
15.10
B
C


ATOM
11824
NZ
LYS
B
210
83.951
28.393
−30.523
1.00
14.52
B
N


ATOM
11828
C
LYS
B
210
88.218
31.861
−25.437
1.00
16.75
B
C


ATOM
11829
O
LYS
B
210
89.311
32.145
−25.928
1.00
17.30
B
O


ATOM
11831
N
LYS
B
211
87.555
32.687
−24.627
1.00
17.35
B
N


ATOM
11832
CA
LYS
B
211
88.104
33.994
−24.247
1.00
17.95
B
C


ATOM
11834
CB
LYS
B
211
87.083
34.814
−23.445
1.00
18.18
B
C


ATOM
11837
CG
LYS
B
211
85.851
35.242
−24.233
1.00
18.73
B
C


ATOM
11840
CD
LYS
B
211
85.015
36.254
−23.458
1.00
19.41
B
C


ATOM
11843
CE
LYS
B
211
83.593
36.355
−24.010
1.00
20.51
B
C


ATOM
11846
NZ
LYS
B
211
83.552
36.703
−25.461
1.00
20.75
B
N


ATOM
11850
C
LYS
B
211
89.388
33.830
−23.431
1.00
18.28
B
C


ATOM
11851
O
LYS
B
211
89.364
33.281
−22.329
1.00
18.16
B
O


ATOM
11853
N
GLU
B
212
90.503
34.311
−23.978
1.00
18.88
B
N


ATOM
11854
CA
GLU
B
212
91.801
34.227
−23.300
1.00
19.31
B
C


ATOM
11856
CB
GLU
B
212
92.933
34.639
−24.248
1.00
19.39
B
C


ATOM
11859
CG
GLU
B
212
94.323
34.194
−23.793
1.00
19.97
B
C


ATOM
11862
CD
GLU
B
212
95.445
34.816
−24.608
1.00
20.72
B
C


ATOM
11863
OE1
GLU
B
212
95.377
36.028
−24.905
1.00
21.30
B
O


ATOM
11864
OE2
GLU
B
212
96.407
34.093
−24.941
1.00
20.66
B
O


ATOM
11865
C
GLU
B
212
91.831
35.098
−22.040
1.00
19.46
B
C


ATOM
11866
O
GLU
B
212
92.651
34.880
−21.146
1.00
19.79
B
O


ATOM
11868
N
ASP
B
213
90.932
36.078
−21.979
1.00
19.22
B
N


ATOM
11869
CA
ASP
B
213
90.816
36.973
−20.830
1.00
19.09
B
C


ATOM
11871
CB
ASP
B
213
90.503
38.398
−21.309
1.00
19.27
B
C


ATOM
11874
CG
ASP
B
213
89.263
38.464
−22.186
1.00
19.40
B
C


ATOM
11875
OD1
ASP
B
213
89.198
37.713
−23.183
1.00
19.36
B
O


ATOM
11876
OD2
ASP
B
213
88.360
39.271
−21.884
1.00
21.12
B
O


ATOM
11877
C
ASP
B
213
89.750
36.516
−19.828
1.00
18.88
B
C


ATOM
11878
O
ASP
B
213
89.341
37.294
−18.966
1.00
19.17
B
O


ATOM
11880
N
ALA
B
214
89.316
35.260
−19.926
1.00
18.57
B
N


ATOM
11881
CA
ALA
B
214
88.229
34.750
−19.084
1.00
18.24
B
C


ATOM
11883
CB
ALA
B
214
87.574
33.549
−19.740
1.00
18.18
B
C


ATOM
11887
C
ALA
B
214
88.712
34.383
−17.683
1.00
18.02
B
C


ATOM
11888
O
ALA
B
214
89.828
33.891
−17.511
1.00
17.90
B
O


ATOM
11890
N
ASN
B
215
87.857
34.627
−16.690
1.00
17.91
B
N


ATOM
11891
CA
ASN
B
215
88.151
34.300
−15.297
1.00
17.91
B
C


ATOM
11893
CB
ASN
B
215
87.225
35.079
−14.355
1.00
17.98
B
C


ATOM
11896
CG
ASN
B
215
87.530
34.835
−12.882
1.00
18.96
B
C


ATOM
11897
OD1
ASN
B
215
88.546
34.235
−12.531
1.00
20.95
B
O


ATOM
11898
ND2
ASN
B
215
86.646
35.311
−12.012
1.00
20.55
B
N


ATOM
11901
C
ASN
B
215
87.989
32.801
−15.079
1.00
17.88
B
C


ATOM
11902
O
ASN
B
215
86.871
32.288
−15.067
1.00
18.40
B
O


ATOM
11904
N
GLN
B
216
89.110
32.109
−14.897
1.00
17.67
B
N


ATOM
11905
CA
GLN
B
216
89.123
30.648
−14.814
1.00
17.28
B
C


ATOM
11907
CB
GLN
B
216
90.559
30.125
−14.732
1.00
17.40
B
C


ATOM
11910
CG
GLN
B
216
91.454
30.489
−15.919
1.00
18.55
B
C


ATOM
11913
CD
GLN
B
216
91.101
29.741
−17.193
1.00
19.04
B
C


ATOM
11914
OE1
GLN
B
216
90.043
29.961
−17.788
1.00
19.21
B
O


ATOM
11915
NE2
GLN
B
216
91.999
28.863
−17.628
1.00
20.05
B
N


ATOM
11918
C
GLN
B
216
88.334
30.149
−13.610
1.00
16.63
B
C


ATOM
11919
O
GLN
B
216
87.517
29.234
−13.733
1.00
16.72
B
O


ATOM
11921
N
VAL
B
217
88.583
30.759
−12.453
1.00
15.82
B
N


ATOM
11922
CA
VAL
B
217
87.865
30.422
−11.224
1.00
15.08
B
C


ATOM
11924
CB
VAL
B
217
88.187
31.414
−10.079
1.00
15.07
B
C


ATOM
11926
CG1
VAL
B
217
87.308
31.142
−8.868
1.00
14.72
B
C


ATOM
11930
CG2
VAL
B
217
89.660
31.324
−9.694
1.00
15.15
B
C


ATOM
11934
C
VAL
B
217
86.360
30.394
−11.481
1.00
14.47
B
C


ATOM
11935
O
VAL
B
217
85.678
29.458
−11.067
1.00
14.91
B
O


ATOM
11937
N
LEU
B
218
85.852
31.405
−12.180
1.00
13.50
B
N


ATOM
11938
CA
LEU
B
218
84.441
31.437
−12.553
1.00
12.95
B
C


ATOM
11940
CB
LEU
B
218
84.069
32.789
−13.179
1.00
12.79
B
C


ATOM
11943
CG
LEU
B
218
82.617
32.980
−13.641
1.00
11.49
B
C


ATOM
11945
CD1
LEU
B
218
81.627
32.691
−12.524
1.00
8.68
B
C


ATOM
11949
CD2
LEU
B
218
82.416
34.384
−14.174
1.00
10.75
B
C


ATOM
11953
C
LEU
B
218
84.110
30.301
−13.517
1.00
12.90
B
C


ATOM
11954
O
LEU
B
218
83.134
29.579
−13.311
1.00
13.48
B
O


ATOM
11956
N
LEU
B
219
84.930
30.144
−14.555
1.00
12.44
B
N


ATOM
11957
CA
LEU
B
219
84.683
29.154
−15.609
1.00
12.25
B
C


ATOM
11959
CB
LEU
B
219
85.739
29.272
−16.715
1.00
12.47
B
C


ATOM
11962
CG
LEU
B
219
85.676
28.253
−17.864
1.00
13.40
B
C


ATOM
11964
CD1
LEU
B
219
84.303
28.247
−18.520
1.00
12.39
B
C


ATOM
11968
CD2
LEU
B
219
86.761
28.534
−18.896
1.00
13.97
B
C


ATOM
11972
C
LEU
B
219
84.649
27.720
−15.079
1.00
11.89
B
C


ATOM
11973
O
LEU
B
219
83.772
26.938
−15.451
1.00
12.23
B
O


ATOM
11975
N
GLU
B
220
85.607
27.379
−14.222
1.00
11.04
B
N


ATOM
11976
CA
GLU
B
220
85.691
26.034
−13.648
1.00
10.39
B
C


ATOM
11978
CB
GLU
B
220
86.885
25.938
−12.694
1.00
10.57
B
C


ATOM
11981
CG
GLU
B
220
87.164
24.540
−12.157
1.00
10.41
B
C


ATOM
11984
CD
GLU
B
220
88.415
24.484
−11.300
1.00
11.88
B
C


ATOM
11985
OE1
GLU
B
220
89.036
25.544
−11.076
1.00
13.40
B
O


ATOM
11986
OE2
GLU
B
220
88.779
23.380
−10.846
1.00
13.69
B
O


ATOM
11987
C
GLU
B
220
84.401
25.682
−12.913
1.00
9.41
B
C


ATOM
11988
O
GLU
B
220
83.838
24.607
−13.110
1.00
9.34
B
O


ATOM
11990
N
LEU
B
221
83.944
26.604
−12.072
1.00
8.59
B
N


ATOM
11991
CA
LEU
B
221
82.689
26.452
−11.338
1.00
7.91
B
C


ATOM
11993
CB
LEU
B
221
82.470
27.675
−10.445
1.00
7.25
B
C


ATOM
11996
CG
LEU
B
221
81.299
27.637
−9.470
1.00
5.48
B
C


ATOM
11998
CD1
LEU
B
221
81.473
26.510
−8.472
1.00
2.94
B
C


ATOM
12002
CD2
LEU
B
221
81.180
28.974
−8.765
1.00
3.79
B
C


ATOM
12006
C
LEU
B
221
81.507
26.285
−12.298
1.00
8.00
B
C


ATOM
12007
O
LEU
B
221
80.662
25.402
−12.116
1.00
7.50
B
O


ATOM
12009
N
ALA
B
222
81.464
27.141
−13.316
1.00
7.90
B
N


ATOM
12010
CA
ALA
B
222
80.434
27.087
−14.348
1.00
8.12
B
C


ATOM
12012
CB
ALA
B
222
80.752
28.080
−15.451
1.00
8.09
B
C


ATOM
12016
C
ALA
B
222
80.287
25.684
−14.933
1.00
8.56
B
C


ATOM
12017
O
ALA
B
222
79.171
25.191
−15.104
1.00
8.85
B
O


ATOM
12019
N
ILE
B
223
81.418
25.048
−15.230
1.00
8.90
B
N


ATOM
12020
CA
ILE
B
223
81.428
23.699
−15.793
1.00
9.10
B
C


ATOM
12022
CB
ILE
B
223
82.812
23.336
−16.366
1.00
9.15
B
C


ATOM
12024
CG1
ILE
B
223
83.153
24.241
−17.550
1.00
9.69
B
C


ATOM
12027
CD1
ILE
B
223
84.570
24.078
−18.041
1.00
11.92
B
C


ATOM
12031
CG2
ILE
B
223
82.845
21.881
−16.816
1.00
8.99
B
C


ATOM
12035
C
ILE
B
223
81.030
22.657
−14.750
1.00
9.24
B
C


ATOM
12036
O
ILE
B
223
80.215
21.777
−15.028
1.00
9.09
B
O


ATOM
12038
N
LEU
B
224
81.612
22.756
−13.557
1.00
9.68
B
N


ATOM
12039
CA
LEU
B
224
81.306
21.822
−12.468
1.00
10.03
B
C


ATOM
12041
CB
LEU
B
224
82.114
22.156
−11.208
1.00
9.46
B
C


ATOM
12044
CG
LEU
B
224
83.367
21.311
−10.988
1.00
9.22
B
C


ATOM
12046
CD1
LEU
B
224
84.199
21.177
−12.262
1.00
8.16
B
C


ATOM
12050
CD2
LEU
B
224
84.193
21.895
−9.856
1.00
10.80
B
C


ATOM
12054
C
LEU
B
224
79.821
21.809
−12.130
1.00
10.73
B
C


ATOM
12055
O
LEU
B
224
79.209
20.742
−12.032
1.00
10.93
B
O


ATOM
12057
N
ASP
B
225
79.252
22.999
−11.959
1.00
11.11
B
N


ATOM
12058
CA
ASP
B
225
77.860
23.124
−11.556
1.00
11.25
B
C


ATOM
12060
CB
ASP
B
225
77.505
24.585
−11.282
1.00
11.10
B
C


ATOM
12063
CG
ASP
B
225
76.227
24.727
−10.487
1.00
11.83
B
C


ATOM
12064
OD1
ASP
B
225
75.198
25.135
−11.071
1.00
10.54
B
O


ATOM
12065
OD2
ASP
B
225
76.248
24.405
−9.280
1.00
11.82
B
O


ATOM
12066
C
ASP
B
225
76.939
22.549
−12.627
1.00
11.77
B
C


ATOM
12067
O
ASP
B
225
76.014
21.798
−12.316
1.00
11.63
B
O


ATOM
12069
N
TYR
B
226
77.209
22.891
−13.885
1.00
12.20
B
N


ATOM
12070
CA
TYR
B
226
76.415
22.393
−15.005
1.00
12.70
B
C


ATOM
12072
CB
TYR
B
226
76.962
22.925
−16.332
1.00
12.61
B
C


ATOM
12075
CG
TYR
B
226
76.133
22.538
−17.541
1.00
12.38
B
C


ATOM
12076
CD1
TYR
B
226
75.212
23.421
−18.090
1.00
12.61
B
C


ATOM
12078
CE1
TYR
B
226
74.455
23.069
−19.199
1.00
13.81
B
C


ATOM
12080
CZ
TYR
B
226
74.615
21.818
−19.768
1.00
13.32
B
C


ATOM
12081
OH
TYR
B
226
73.869
21.457
−20.866
1.00
14.04
B
O


ATOM
12083
CE2
TYR
B
226
75.522
20.926
−19.239
1.00
11.80
B
C


ATOM
12085
CD2
TYR
B
226
76.274
21.287
−18.135
1.00
11.70
B
C


ATOM
12087
C
TYR
B
226
76.365
20.861
−15.025
1.00
13.36
B
C


ATOM
12088
O
TYR
B
226
75.290
20.273
−15.170
1.00
14.07
B
O


ATOM
12090
N
ASN
B
227
77.527
20.225
−14.882
1.00
13.50
B
N


ATOM
12091
CA
ASN
B
227
77.611
18.764
−14.862
1.00
13.63
B
C


ATOM
12093
CB
ASN
B
227
79.074
18.302
−14.837
1.00
13.86
B
C


ATOM
12096
CG
ASN
B
227
79.789
18.524
−16.161
1.00
14.25
B
C


ATOM
12097
OD1
ASN
B
227
79.172
18.516
−17.230
1.00
13.18
B
O


ATOM
12098
ND2
ASN
B
227
81.104
18.712
−16.094
1.00
12.89
B
N


ATOM
12101
C
ASN
B
227
76.866
18.166
−13.673
1.00
13.81
B
C


ATOM
12102
O
ASN
B
227
76.139
17.186
−13.824
1.00
13.98
B
O


ATOM
12104
N
MET
B
228
77.053
18.757
−12.495
1.00
14.03
B
N


ATOM
12105
CA
MET
B
228
76.345
18.325
−11.288
1.00
14.59
B
C


ATOM
12107
CB
MET
B
228
76.698
19.234
−10.107
1.00
15.31
B
C


ATOM
12110
CG
MET
B
228
75.985
18.894
−8.792
1.00
16.38
B
C


ATOM
12113
SD
MET
B
228
75.944
20.288
−7.645
1.00
18.68
B
S


ATOM
12114
CE
MET
B
228
74.714
21.327
−8.435
1.00
17.56
B
C


ATOM
12118
C
MET
B
228
74.835
18.345
−11.507
1.00
14.50
B
C


ATOM
12119
O
MET
B
228
74.136
17.402
−11.138
1.00
14.64
B
O


ATOM
12121
N
ILE
B
229
74.337
19.427
−12.097
1.00
14.25
B
N


ATOM
12122
CA
ILE
B
229
72.916
19.538
−12.398
1.00
14.20
B
C


ATOM
12124
CB
ILE
B
229
72.537
20.957
−12.857
1.00
14.37
B
C


ATOM
12126
CG1
ILE
B
229
72.802
21.973
−11.741
1.00
14.47
B
C


ATOM
12129
CD1
ILE
B
229
72.024
23.268
−11.891
1.00
13.51
B
C


ATOM
12133
CG2
ILE
B
229
71.074
21.011
−13.262
1.00
15.42
B
C


ATOM
12137
C
ILE
B
229
72.528
18.523
−13.470
1.00
13.75
B
C


ATOM
12138
O
ILE
B
229
71.558
17.789
−13.310
1.00
13.08
B
O


ATOM
12140
N
GLN
B
230
73.297
18.476
−14.554
1.00
14.01
B
N


ATOM
12141
CA
GLN
B
230
73.092
17.472
−15.599
1.00
14.55
B
C


ATOM
12143
CB
GLN
B
230
74.216
17.535
−16.640
1.00
14.49
B
C


ATOM
12146
CG
GLN
B
230
74.086
16.503
−17.757
1.00
13.89
B
C


ATOM
12149
CD
GLN
B
230
75.223
16.564
−18.755
1.00
12.94
B
C


ATOM
12150
OE1
GLN
B
230
76.100
15.701
−18.761
1.00
12.13
B
O


ATOM
12151
NE2
GLN
B
230
75.213
17.582
−19.608
1.00
10.57
B
N


ATOM
12154
C
GLN
B
230
72.996
16.052
−15.026
1.00
15.29
B
C


ATOM
12155
O
GLN
B
230
72.177
15.255
−15.481
1.00
15.71
B
O


ATOM
12157
N
SER
B
231
73.832
15.739
−14.037
1.00
15.66
B
N


ATOM
12158
CA
SER
B
231
73.793
14.425
−13.387
1.00
15.81
B
C


ATOM
12160
CB
SER
B
231
75.004
14.227
−12.468
1.00
15.73
B
C


ATOM
12163
OG
SER
B
231
74.848
14.926
−11.246
1.00
16.09
B
O


ATOM
12165
C
SER
B
231
72.492
14.223
−12.600
1.00
16.06
B
C


ATOM
12166
O
SER
B
231
71.989
13.102
−12.511
1.00
15.88
B
O


ATOM
12168
N
VAL
B
232
71.959
15.306
−12.034
1.00
16.47
B
N


ATOM
12169
CA
VAL
B
232
70.661
15.266
−11.355
1.00
16.95
B
C


ATOM
12171
CB
VAL
B
232
70.343
16.593
−10.607
1.00
17.13
B
C


ATOM
12173
CG1
VAL
B
232
68.971
16.529
−9.941
1.00
16.99
B
C


ATOM
12177
CG2
VAL
B
232
71.412
16.892
−9.570
1.00
18.25
B
C


ATOM
12181
C
VAL
B
232
69.543
14.957
−12.355
1.00
17.08
B
C


ATOM
12182
O
VAL
B
232
68.608
14.229
−12.032
1.00
17.31
B
O


ATOM
12184
N
TYR
B
233
69.646
15.502
−13.566
1.00
17.20
B
N


ATOM
12185
CA
TYR
B
233
68.679
15.203
−14.624
1.00
17.30
B
C


ATOM
12187
CB
TYR
B
233
68.880
16.109
−15.842
1.00
17.15
B
C


ATOM
12190
CG
TYR
B
233
68.763
17.600
−15.593
1.00
16.58
B
C


ATOM
12191
CD1
TYR
B
233
68.056
18.113
−14.502
1.00
14.97
B
C


ATOM
12193
CE1
TYR
B
233
67.957
19.481
−14.296
1.00
14.04
B
C


ATOM
12195
CZ
TYR
B
233
68.549
20.349
−15.194
1.00
14.25
B
C


ATOM
12196
OH
TYR
B
233
68.461
21.706
−15.012
1.00
13.90
B
O


ATOM
12198
CE2
TYR
B
233
69.240
19.866
−16.283
1.00
15.45
B
C


ATOM
12200
CD2
TYR
B
233
69.341
18.503
−16.479
1.00
16.33
B
C


ATOM
12202
C
TYR
B
233
68.782
13.750
−15.077
1.00
17.89
B
C


ATOM
12203
O
TYR
B
233
67.772
13.135
−15.421
1.00
18.00
B
O


ATOM
12205
N
GLN
B
234
70.003
13.215
−15.093
1.00
18.54
B
N


ATOM
12206
CA
GLN
B
234
70.234
11.817
−15.465
1.00
18.95
B
C


ATOM
12208
CB
GLN
B
234
71.730
11.535
−15.644
1.00
18.86
B
C


ATOM
12211
CG
GLN
B
234
72.324
12.116
−16.920
1.00
18.09
B
C


ATOM
12214
CD
GLN
B
234
73.816
11.854
−17.051
1.00
17.24
B
C


ATOM
12215
OE1
GLN
B
234
74.324
10.830
−16.593
1.00
17.14
B
O


ATOM
12216
NE2
GLN
B
234
74.524
12.779
−17.686
1.00
15.08
B
N


ATOM
12219
C
GLN
B
234
69.638
10.858
−14.434
1.00
19.60
B
C


ATOM
12220
O
GLN
B
234
69.011
9.865
−14.802
1.00
19.31
B
O


ATOM
12222
N
ARG
B
235
69.837
11.156
−13.151
1.00
20.61
B
N


ATOM
12223
CA
ARG
B
235
69.232
10.365
−12.074
1.00
21.86
B
C


ATOM
12225
CB
ARG
B
235
69.842
10.722
−10.712
1.00
22.48
B
C


ATOM
12228
CG
ARG
B
235
69.357
9.837
−9.562
1.00
24.72
B
C


ATOM
12231
CD
ARG
B
235
70.130
10.088
−8.272
1.00
28.63
B
C


ATOM
12234
NE
ARG
B
235
70.043
11.485
−7.828
1.00
32.42
B
N


ATOM
12236
CZ
ARG
B
235
71.016
12.398
−7.918
1.00
33.76
B
C


ATOM
12237
NH1
ARG
B
235
72.205
12.098
−8.440
1.00
34.56
B
N


ATOM
12240
NH2
ARG
B
235
70.799
13.633
−7.472
1.00
33.57
B
N


ATOM
12243
C
ARG
B
235
67.710
10.550
−12.039
1.00
21.94
B
C


ATOM
12244
O
ARG
B
235
66.976
9.623
−11.687
1.00
22.34
B
O


ATOM
12246
N
ASP
B
236
67.244
11.745
−12.393
1.00
21.69
B
N


ATOM
12247
CA
ASP
B
236
65.818
11.975
−12.584
1.00
21.55
B
C


ATOM
12249
CB
ASP
B
236
65.530
13.445
−12.920
1.00
21.49
B
C


ATOM
12252
CG
ASP
B
236
65.742
14.384
−11.737
1.00
21.70
B
C


ATOM
12253
OD1
ASP
B
236
65.961
13.915
−10.601
1.00
22.53
B
O


ATOM
12254
OD2
ASP
B
236
65.694
15.611
−11.951
1.00
20.61
B
O


ATOM
12255
C
ASP
B
236
65.324
11.086
−13.719
1.00
21.53
B
C


ATOM
12256
O
ASP
B
236
64.440
10.255
−13.520
1.00
21.51
B
O


ATOM
12258
N
LEU
B
237
65.929
11.247
−14.895
1.00
21.85
B
N


ATOM
12259
CA
LEU
B
237
65.483
10.568
−16.117
1.00
22.44
B
C


ATOM
12261
CB
LEU
B
237
66.369
10.963
−17.307
1.00
22.59
B
C


ATOM
12264
CG
LEU
B
237
65.987
10.394
−18.683
1.00
22.86
B
C


ATOM
12266
CD1
LEU
B
237
64.591
10.840
−19.099
1.00
22.39
B
C


ATOM
12270
CD2
LEU
B
237
67.011
10.801
−19.734
1.00
23.22
B
C


ATOM
12274
C
LEU
B
237
65.435
9.043
−16.002
1.00
22.87
B
C


ATOM
12275
O
LEU
B
237
64.508
8.421
−16.518
1.00
23.17
B
O


ATOM
12277
N
ARG
B
238
66.429
8.445
−15.347
1.00
23.22
B
N


ATOM
12278
CA
ARG
B
238
66.465
6.986
−15.167
1.00
23.20
B
C


ATOM
12280
CB
ARG
B
238
67.747
6.544
−14.453
1.00
23.33
B
C


ATOM
12283
CG
ARG
B
238
68.977
6.488
−15.348
1.00
24.49
B
C


ATOM
12286
CD
ARG
B
238
70.111
5.717
−14.683
1.00
25.92
B
C


ATOM
12289
NE
ARG
B
238
70.498
6.303
−13.397
1.00
27.40
B
N


ATOM
12291
CZ
ARG
B
238
71.452
7.219
−13.216
1.00
27.20
B
C


ATOM
12292
NH1
ARG
B
238
72.161
7.693
−14.239
1.00
26.98
B
N


ATOM
12295
NH2
ARG
B
238
71.701
7.669
−11.991
1.00
27.09
B
N


ATOM
12298
C
ARG
B
238
65.253
6.480
−14.393
1.00
23.04
B
C


ATOM
12299
O
ARG
B
238
64.725
5.416
−14.697
1.00
22.74
B
O


ATOM
12301
N
GLU
B
239
64.822
7.252
−13.397
1.00
23.57
B
N


ATOM
12302
CA
GLU
B
239
63.645
6.916
−12.592
1.00
24.22
B
C


ATOM
12304
CB
GLU
B
239
63.617
7.774
−11.322
1.00
24.77
B
C


ATOM
12307
CG
GLU
B
239
62.618
7.317
−10.265
1.00
26.77
B
C


ATOM
12310
CD
GLU
B
239
62.813
8.028
−8.934
1.00
29.81
B
C


ATOM
12311
OE1
GLU
B
239
63.910
7.911
−8.348
1.00
30.83
B
O


ATOM
12312
OE2
GLU
B
239
61.867
8.702
−8.469
1.00
32.55
B
O


ATOM
12313
C
GLU
B
239
62.338
7.085
−13.382
1.00
23.78
B
C


ATOM
12314
O
GLU
B
239
61.406
6.293
−13.224
1.00
23.75
B
O


ATOM
12316
N
THR
B
240
62.271
8.115
−14.222
1.00
23.31
B
N


ATOM
12317
CA
THR
B
240
61.130
8.298
−15.122
1.00
23.25
B
C


ATOM
12319
CB
THR
B
240
61.132
9.703
−15.767
1.00
23.05
B
C


ATOM
12321
OG1
THR
B
240
61.223
10.703
−14.746
1.00
22.86
B
O


ATOM
12323
CG2
THR
B
240
59.862
9.932
−16.574
1.00
22.22
B
C


ATOM
12327
C
THR
B
240
61.135
7.236
−16.227
1.00
23.58
B
C


ATOM
12328
O
THR
B
240
60.076
6.746
−16.630
1.00
23.36
B
O


ATOM
12330
N
SER
B
241
62.330
6.888
−16.707
1.00
23.85
B
N


ATOM
12331
CA
SER
B
241
62.500
5.878
−17.758
1.00
24.00
B
C


ATOM
12333
CB
SER
B
241
63.943
5.868
−18.271
1.00
24.23
B
C


ATOM
12336
OG
SER
B
241
64.304
7.126
−18.813
1.00
25.12
B
O


ATOM
12338
C
SER
B
241
62.124
4.479
−17.280
1.00
24.04
B
C


ATOM
12339
O
SER
B
241
61.531
3.705
−18.032
1.00
23.92
B
O


ATOM
12341
N
ARG
B
242
62.483
4.151
−16.039
1.00
24.20
B
N


ATOM
12342
CA
ARG
B
242
62.037
2.900
−15.427
1.00
24.47
B
C


ATOM
12344
CB
ARG
B
242
62.565
2.741
−13.992
1.00
24.64
B
C


ATOM
12347
CG
ARG
B
242
63.977
2.149
−13.889
1.00
25.62
B
C


ATOM
12350
CD
ARG
B
242
64.220
1.493
−12.525
1.00
25.82
B
C


ATOM
12353
NE
ARG
B
242
63.800
2.347
−11.411
1.00
26.44
B
N


ATOM
12355
CZ
ARG
B
242
64.518
3.342
−10.885
1.00
26.48
B
C


ATOM
12356
NH1
ARG
B
242
64.020
4.045
−9.874
1.00
25.75
B
N


ATOM
12359
NH2
ARG
B
242
65.725
3.644
−11.356
1.00
27.75
B
N


ATOM
12362
C
ARG
B
242
60.512
2.851
−15.429
1.00
24.30
B
C


ATOM
12363
O
ARG
B
242
59.919
1.885
−15.909
1.00
24.90
B
O


ATOM
12365
N
TRP
B
243
59.887
3.903
−14.906
1.00
23.61
B
N


ATOM
12366
CA
TRP
B
243
58.429
4.000
−14.888
1.00
22.97
B
C


ATOM
12368
CB
TRP
B
243
57.982
5.318
−14.237
1.00
22.79
B
C


ATOM
12371
CG
TRP
B
243
56.531
5.655
−14.463
1.00
21.51
B
C


ATOM
12372
CD1
TRP
B
243
55.465
5.256
−13.708
1.00
20.30
B
C


ATOM
12374
NE1
TRP
B
243
54.301
5.768
−14.228
1.00
19.74
B
N


ATOM
12376
CE2
TRP
B
243
54.599
6.513
−15.339
1.00
19.29
B
C


ATOM
12377
CD2
TRP
B
243
55.995
6.466
−15.517
1.00
19.30
B
C


ATOM
12378
CE3
TRP
B
243
56.561
7.151
−16.597
1.00
18.07
B
C


ATOM
12380
CZ3
TRP
B
243
55.728
7.850
−17.453
1.00
17.55
B
C


ATOM
12382
CH2
TRP
B
243
54.344
7.880
−17.252
1.00
17.66
B
C


ATOM
12384
CZ2
TRP
B
243
53.759
7.218
−16.205
1.00
19.44
B
C


ATOM
12386
C
TRP
B
243
57.852
3.879
−16.299
1.00
22.95
B
C


ATOM
12387
O
TRP
B
243
56.882
3.151
−16.515
1.00
23.06
B
O


ATOM
12389
N
TRP
B
244
58.457
4.585
−17.252
1.00
22.77
B
N


ATOM
12390
CA
TRP
B
244
57.944
4.624
−18.624
1.00
22.56
B
C


ATOM
12392
CB
TRP
B
244
58.743
5.624
−19.473
1.00
22.41
B
C


ATOM
12395
CG
TRP
B
244
58.196
5.866
−20.872
1.00
21.79
B
C


ATOM
12396
CD1
TRP
B
244
58.907
5.853
−22.041
1.00
21.43
B
C


ATOM
12398
NE1
TRP
B
244
58.078
6.124
−23.105
1.00
20.15
B
N


ATOM
12400
CE2
TRP
B
244
56.804
6.314
−22.641
1.00
18.38
B
C


ATOM
12401
CD2
TRP
B
244
56.836
6.162
−21.238
1.00
19.68
B
C


ATOM
12402
CE3
TRP
B
244
55.644
6.312
−20.517
1.00
17.93
B
C


ATOM
12404
CZ3
TRP
B
244
54.482
6.602
−21.206
1.00
16.17
B
C


ATOM
12406
CH2
TRP
B
244
54.483
6.745
−22.599
1.00
16.40
B
C


ATOM
12408
CZ2
TRP
B
244
55.631
6.605
−23.333
1.00
16.86
B
C


ATOM
12410
C
TRP
B
244
57.951
3.241
−19.268
1.00
22.60
B
C


ATOM
12411
O
TRP
B
244
57.038
2.906
−20.023
1.00
23.08
B
O


ATOM
12413
N
ARG
B
245
58.967
2.443
−18.951
1.00
22.59
B
N


ATOM
12414
CA
ARG
B
245
59.086
1.083
−19.483
1.00
22.68
B
C


ATOM
12416
CB
ARG
B
245
60.484
0.511
−19.208
1.00
22.97
B
C


ATOM
12419
CG
ARG
B
245
61.171
−0.073
−20.439
1.00
24.49
B
C


ATOM
12422
CD
ARG
B
245
62.637
−0.418
−20.184
1.00
26.62
B
C


ATOM
12425
NE
ARG
B
245
63.364
0.675
−19.532
1.00
29.64
B
N


ATOM
12427
CZ
ARG
B
245
63.829
0.665
−18.278
1.00
32.38
B
C


ATOM
12428
NH1
ARG
B
245
64.468
1.734
−17.808
1.00
32.81
B
N


ATOM
12431
NH2
ARG
B
245
63.675
−0.395
−17.485
1.00
32.73
B
N


ATOM
12434
C
ARG
B
245
58.011
0.172
−18.885
1.00
22.31
B
C


ATOM
12435
O
ARG
B
245
57.367
−0.580
−19.610
1.00
22.44
B
O


ATOM
12437
N
ARG
B
246
57.825
0.255
−17.567
1.00
22.29
B
N


ATOM
12438
CA
ARG
B
246
56.787
−0.507
−16.850
1.00
22.34
B
C


ATOM
12440
CB
ARG
B
246
56.771
−0.127
−15.363
1.00
22.79
B
C


ATOM
12443
CG
ARG
B
246
57.920
−0.713
−14.543
1.00
25.55
B
C


ATOM
12446
CD
ARG
B
246
57.440
−1.710
−13.486
1.00
28.55
B
C


ATOM
12449
NE
ARG
B
246
56.772
−2.885
−14.050
1.00
30.25
B
N


ATOM
12451
CZ
ARG
B
246
56.294
−3.902
−13.330
1.00
31.54
B
C


ATOM
12452
NH1
ARG
B
246
55.701
−4.922
−13.939
1.00
31.77
B
N


ATOM
12455
NH2
ARG
B
246
56.406
−3.910
−12.004
1.00
32.68
B
N


ATOM
12458
C
ARG
B
246
55.395
−0.282
−17.433
1.00
21.44
B
C


ATOM
12459
O
ARG
B
246
54.664
−1.236
−17.698
1.00
21.29
B
O


ATOM
12461
N
VAL
B
247
55.031
0.985
−17.612
1.00
20.80
B
N


ATOM
12462
CA
VAL
B
247
53.776
1.340
−18.268
1.00
20.16
B
C


ATOM
12464
CB
VAL
B
247
53.602
2.872
−18.404
1.00
19.88
B
C


ATOM
12466
CG1
VAL
B
247
53.749
3.555
−17.056
1.00
18.27
B
C


ATOM
12470
CG2
VAL
B
247
52.252
3.203
−19.016
1.00
19.22
B
C


ATOM
12474
C
VAL
B
247
53.777
0.705
−19.653
1.00
20.35
B
C


ATOM
12475
O
VAL
B
247
52.834
0.012
−20.024
1.00
19.91
B
O


ATOM
12477
N
GLY
B
248
54.856
0.941
−20.398
1.00
20.85
B
N


ATOM
12478
CA
GLY
B
248
55.099
0.287
−21.684
1.00
21.09
B
C


ATOM
12481
C
GLY
B
248
54.039
0.561
−22.731
1.00
21.48
B
C


ATOM
12482
O
GLY
B
248
53.686
−0.327
−23.509
1.00
21.44
B
O


ATOM
12484
N
LEU
B
249
53.539
1.792
−22.763
1.00
21.90
B
N


ATOM
12485
CA
LEU
B
249
52.414
2.128
−23.633
1.00
22.39
B
C


ATOM
12487
CB
LEU
B
249
51.736
3.423
−23.164
1.00
22.22
B
C


ATOM
12490
CG
LEU
B
249
50.264
3.619
−23.549
1.00
21.67
B
C


ATOM
12492
CD1
LEU
B
249
49.396
2.466
−23.060
1.00
19.27
B
C


ATOM
12496
CD2
LEU
B
249
49.741
4.948
−23.007
1.00
21.26
B
C


ATOM
12500
C
LEU
B
249
52.844
2.229
−25.102
1.00
23.09
B
C


ATOM
12501
O
LEU
B
249
52.140
1.744
−25.989
1.00
23.40
B
O


ATOM
12503
N
ALA
B
250
54.004
2.837
−25.351
1.00
23.56
B
N


ATOM
12504
CA
ALA
B
250
54.523
2.999
−26.717
1.00
23.56
B
C


ATOM
12506
CB
ALA
B
250
55.778
3.867
−26.708
1.00
23.75
B
C


ATOM
12510
C
ALA
B
250
54.812
1.661
−27.406
1.00
23.27
B
C


ATOM
12511
O
ALA
B
250
54.632
1.533
−28.621
1.00
22.94
B
O


ATOM
12513
N
THR
B
251
55.261
0.677
−26.630
1.00
23.12
B
N


ATOM
12514
CA
THR
B
251
55.528
−0.665
−27.151
1.00
23.11
B
C


ATOM
12516
CB
THR
B
251
56.313
−1.525
−26.133
1.00
23.00
B
C


ATOM
12518
OG1
THR
B
251
57.569
−0.903
−25.843
1.00
23.41
B
O


ATOM
12520
CG2
THR
B
251
56.567
−2.922
−26.682
1.00
23.17
B
C


ATOM
12524
C
THR
B
251
54.240
−1.402
−27.518
1.00
22.91
B
C


ATOM
12525
O
THR
B
251
54.183
−2.081
−28.544
1.00
23.01
B
O


ATOM
12527
N
LYS
B
252
53.213
−1.259
−26.683
1.00
22.75
B
N


ATOM
12528
CA
LYS
B
252
51.970
−2.019
−26.843
1.00
22.97
B
C


ATOM
12530
CB
LYS
B
252
51.347
−2.303
−25.473
1.00
23.14
B
C


ATOM
12533
CG
LYS
B
252
52.249
−3.107
−24.525
1.00
23.20
B
C


ATOM
12536
CD
LYS
B
252
52.403
−4.563
−24.963
1.00
24.47
B
C


ATOM
12539
CE
LYS
B
252
53.339
−5.338
−24.041
1.00
24.49
B
C


ATOM
12542
NZ
LYS
B
252
53.670
−6.689
−24.576
1.00
23.12
B
N


ATOM
12546
C
LYS
B
252
50.949
−1.350
−27.781
1.00
23.11
B
C


ATOM
12547
O
LYS
B
252
50.186
−2.046
−28.457
1.00
23.06
B
O


ATOM
12549
N
LEU
B
253
50.931
−0.017
−27.821
1.00
23.21
B
N


ATOM
12550
CA
LEU
B
253
50.141
0.714
−28.822
1.00
23.39
B
C


ATOM
12552
CB
LEU
B
253
49.629
2.053
−28.276
1.00
23.12
B
C


ATOM
12555
CG
LEU
B
253
48.187
2.044
−27.757
1.00
22.22
B
C


ATOM
12557
CD1
LEU
B
253
47.973
0.942
−26.728
1.00
21.08
B
C


ATOM
12561
CD2
LEU
B
253
47.816
3.406
−27.182
1.00
19.92
B
C


ATOM
12565
C
LEU
B
253
50.979
0.927
−30.085
1.00
24.12
B
C


ATOM
12566
O
LEU
B
253
52.037
1.561
−30.041
1.00
24.39
B
O


ATOM
12568
N
HIS
B
254
50.482
0.411
−31.208
1.00
24.48
B
N


ATOM
12569
CA
HIS
B
254
51.277
0.288
−32.438
1.00
24.66
B
C


ATOM
12571
CB
HIS
B
254
50.733
−0.854
−33.312
1.00
24.99
B
C


ATOM
12574
CG
HIS
B
254
50.385
−2.093
−32.542
1.00
26.11
B
C


ATOM
12575
ND1
HIS
B
254
51.328
−3.020
−32.152
1.00
26.40
B
N


ATOM
12577
CE1
HIS
B
254
50.734
−3.993
−31.484
1.00
26.76
B
C


ATOM
12579
NE2
HIS
B
254
49.441
−3.731
−31.425
1.00
27.08
B
N


ATOM
12581
CD2
HIS
B
254
49.196
−2.548
−32.079
1.00
26.88
B
C


ATOM
12583
C
HIS
B
254
51.339
1.587
−33.248
1.00
24.42
B
C


ATOM
12584
O
HIS
B
254
52.154
1.712
−34.159
1.00
24.54
B
O


ATOM
12586
N
PHE
B
255
50.478
2.543
−32.911
1.00
24.49
B
N


ATOM
12587
CA
PHE
B
255
50.439
3.853
−33.573
1.00
24.65
B
C


ATOM
12589
CB
PHE
B
255
48.984
4.303
−33.758
1.00
24.74
B
C


ATOM
12592
CG
PHE
B
255
48.292
4.626
−32.464
1.00
24.93
B
C


ATOM
12593
CD1
PHE
B
255
48.365
5.903
−31.919
1.00
24.68
B
C


ATOM
12595
CE1
PHE
B
255
47.749
6.196
−30.714
1.00
25.25
B
C


ATOM
12597
CZ
PHE
B
255
47.058
5.204
−30.036
1.00
25.88
B
C


ATOM
12599
CE2
PHE
B
255
46.985
3.925
−30.566
1.00
25.92
B
C


ATOM
12601
CD2
PHE
B
255
47.602
3.641
−31.771
1.00
24.96
B
C


ATOM
12603
C
PHE
B
255
51.179
4.931
−32.772
1.00
24.72
B
C


ATOM
12604
O
PHE
B
255
51.506
5.988
−33.312
1.00
24.47
B
O


ATOM
12606
N
ALA
B
256
51.416
4.665
−31.485
1.00
24.97
B
N


ATOM
12607
CA
ALA
B
256
51.924
5.675
−30.551
1.00
25.20
B
C


ATOM
12609
CB
ALA
B
256
51.462
5.355
−29.132
1.00
24.99
B
C


ATOM
12613
C
ALA
B
256
53.451
5.822
−30.590
1.00
25.60
B
C


ATOM
12614
O
ALA
B
256
54.180
4.845
−30.776
1.00
25.02
B
O


ATOM
12616
N
ARG
B
257
53.911
7.058
−30.389
1.00
26.40
B
N


ATOM
12617
CA
ARG
B
257
55.329
7.410
−30.453
1.00
27.04
B
C


ATOM
12619
CB
ARG
B
257
55.511
8.768
−31.132
1.00
27.31
B
C


ATOM
12622
CG
ARG
B
257
54.920
8.884
−32.530
1.00
28.68
B
C


ATOM
12625
CD
ARG
B
257
54.737
10.347
−32.907
1.00
30.49
B
C


ATOM
12628
NE
ARG
B
257
53.733
10.999
−32.065
1.00
31.91
B
N


ATOM
12630
CZ
ARG
B
257
53.468
12.304
−32.062
1.00
31.98
B
C


ATOM
12631
NH1
ARG
B
257
54.132
13.134
−32.860
1.00
32.59
B
N


ATOM
12634
NH2
ARG
B
257
52.526
12.785
−31.253
1.00
30.73
B
N


ATOM
12637
C
ARG
B
257
55.952
7.496
−29.063
1.00
27.27
B
C


ATOM
12638
O
ARG
B
257
55.380
8.103
−28.153
1.00
26.70
B
O


ATOM
12640
N
ASP
B
258
57.140
6.910
−28.922
1.00
27.82
B
N


ATOM
12641
CA
ASP
B
258
57.907
6.973
−27.680
1.00
28.09
B
C


ATOM
12643
CB
ASP
B
258
58.926
5.822
−27.637
1.00
28.30
B
C


ATOM
12646
CG
ASP
B
258
59.647
5.710
−26.296
1.00
29.74
B
C


ATOM
12647
OD1
ASP
B
258
59.515
6.623
−25.449
1.00
31.58
B
O


ATOM
12648
OD2
ASP
B
258
60.350
4.696
−26.088
1.00
30.24
B
O


ATOM
12649
C
ASP
B
258
58.609
8.335
−27.570
1.00
27.79
B
C


ATOM
12650
O
ASP
B
258
59.694
8.529
−28.122
1.00
27.75
B
O


ATOM
12652
N
ARG
B
259
57.977
9.269
−26.859
1.00
27.57
B
N


ATOM
12653
CA
ARG
B
259
58.547
10.597
−26.621
1.00
27.44
B
C


ATOM
12655
CB
ARG
B
259
57.645
11.691
−27.212
1.00
27.68
B
C


ATOM
12658
CG
ARG
B
259
57.598
11.737
−28.736
1.00
29.41
B
C


ATOM
12661
CD
ARG
B
259
58.884
12.297
−29.341
1.00
30.97
B
C


ATOM
12664
NE
ARG
B
259
58.754
12.551
−30.778
1.00
32.99
B
N


ATOM
12666
CZ
ARG
B
259
58.787
11.616
−31.732
1.00
33.88
B
C


ATOM
12667
NH1
ARG
B
259
58.943
10.329
−31.431
1.00
34.50
B
N


ATOM
12670
NH2
ARG
B
259
58.657
11.972
−33.008
1.00
33.20
B
N


ATOM
12673
C
ARG
B
259
58.728
10.835
−25.124
1.00
26.73
B
C


ATOM
12674
O
ARG
B
259
57.907
11.509
−24.496
1.00
27.01
B
O


ATOM
12676
N
LEU
B
260
59.792
10.270
−24.553
1.00
25.66
B
N


ATOM
12677
CA
LEU
B
260
60.147
10.523
−23.152
1.00
24.71
B
C


ATOM
12679
CB
LEU
B
260
60.396
9.216
−22.388
1.00
24.82
B
C


ATOM
12682
CG
LEU
B
260
60.711
9.346
−20.887
1.00
23.56
B
C


ATOM
12684
CD1
LEU
B
260
59.596
10.059
−20.139
1.00
22.57
B
C


ATOM
12688
CD2
LEU
B
260
60.956
7.982
−20.276
1.00
22.94
B
C


ATOM
12692
C
LEU
B
260
61.381
11.411
−23.075
1.00
23.72
B
C


ATOM
12693
O
LEU
B
260
61.347
12.468
−22.445
1.00
23.35
B
O


ATOM
12695
N
ILE
B
261
62.462
10.979
−23.721
1.00
22.88
B
N


ATOM
12696
CA
ILE
B
261
63.712
11.743
−23.722
1.00
22.59
B
C


ATOM
12698
CB
ILE
B
261
64.773
11.162
−24.691
1.00
22.38
B
C


ATOM
12700
CG1
ILE
B
261
65.102
9.705
−24.357
1.00
22.05
B
C


ATOM
12703
CD1
ILE
B
261
66.110
9.080
−25.307
1.00
21.88
B
C


ATOM
12707
CG2
ILE
B
261
66.056
11.987
−24.628
1.00
21.66
B
C


ATOM
12711
C
ILE
B
261
63.419
13.187
−24.125
1.00
22.69
B
C


ATOM
12712
O
ILE
B
261
63.873
14.128
−23.469
1.00
22.64
B
O


ATOM
12714
N
GLU
B
262
62.641
13.341
−25.196
1.00
22.88
B
N


ATOM
12715
CA
GLU
B
262
62.215
14.655
−25.692
1.00
22.71
B
C


ATOM
12717
CB
GLU
B
262
61.384
14.518
−26.981
1.00
22.85
B
C


ATOM
12720
CG
GLU
B
262
62.176
14.081
−28.228
1.00
23.29
B
C


ATOM
12723
CD
GLU
B
262
62.377
12.568
−28.339
1.00
23.18
B
C


ATOM
12724
OE1
GLU
B
262
62.069
11.832
−27.375
1.00
22.88
B
O


ATOM
12725
OE2
GLU
B
262
62.852
12.113
−29.401
1.00
22.83
B
O


ATOM
12726
C
GLU
B
262
61.397
15.397
−24.639
1.00
22.14
B
C


ATOM
12727
O
GLU
B
262
61.659
16.565
−24.346
1.00
22.04
B
O


ATOM
12729
N
SER
B
263
60.408
14.709
−24.073
1.00
21.51
B
N


ATOM
12730
CA
SER
B
263
59.561
15.292
−23.035
1.00
21.01
B
C


ATOM
12732
CB
SER
B
263
58.448
14.321
−22.627
1.00
20.92
B
C


ATOM
12735
OG
SER
B
263
57.396
14.332
−23.577
1.00
20.64
B
O


ATOM
12737
C
SER
B
263
60.356
15.721
−21.806
1.00
20.77
B
C


ATOM
12738
O
SER
B
263
59.996
16.691
−21.146
1.00
20.59
B
O


ATOM
12740
N
PHE
B
264
61.434
15.008
−21.493
1.00
21.04
B
N


ATOM
12741
CA
PHE
B
264
62.253
15.380
−20.346
1.00
21.42
B
C


ATOM
12743
CB
PHE
B
264
63.143
14.232
−19.886
1.00
21.45
B
C


ATOM
12746
CG
PHE
B
264
63.662
14.426
−18.502
1.00
21.91
B
C


ATOM
12747
CD1
PHE
B
264
62.912
14.019
−17.408
1.00
22.62
B
C


ATOM
12749
CE1
PHE
B
264
63.373
14.220
−16.122
1.00
23.76
B
C


ATOM
12751
CZ
PHE
B
264
64.591
14.848
−15.920
1.00
24.45
B
C


ATOM
12753
CE2
PHE
B
264
65.337
15.273
−17.006
1.00
23.47
B
C


ATOM
12755
CD2
PHE
B
264
64.869
15.068
−18.286
1.00
22.37
B
C


ATOM
12757
C
PHE
B
264
63.107
16.609
−20.639
1.00
21.80
B
C


ATOM
12758
O
PHE
B
264
63.236
17.496
−19.791
1.00
22.35
B
O


ATOM
12760
N
TYR
B
265
63.694
16.649
−21.833
1.00
21.65
B
N


ATOM
12761
CA
TYR
B
265
64.396
17.839
−22.327
1.00
21.35
B
C


ATOM
12763
CB
TYR
B
265
64.916
17.585
−23.747
1.00
21.73
B
C


ATOM
12766
CG
TYR
B
265
65.364
18.817
−24.494
1.00
22.81
B
C


ATOM
12767
CD1
TYR
B
265
66.617
19.372
−24.267
1.00
24.34
B
C


ATOM
12769
CE1
TYR
B
265
67.033
20.501
−24.954
1.00
26.45
B
C


ATOM
12771
CZ
TYR
B
265
66.192
21.083
−25.886
1.00
27.60
B
C


ATOM
12772
OH
TYR
B
265
66.601
22.202
−26.573
1.00
30.92
B
O


ATOM
12774
CE2
TYR
B
265
64.944
20.544
−26.133
1.00
26.49
B
C


ATOM
12776
CD2
TYR
B
265
64.539
19.417
−25.440
1.00
24.55
B
C


ATOM
12778
C
TYR
B
265
63.481
19.070
−22.292
1.00
20.55
B
C


ATOM
12779
O
TYR
B
265
63.923
20.176
−21.983
1.00
20.24
B
O


ATOM
12781
N
TRP
B
266
62.207
18.859
−22.610
1.00
20.01
B
N


ATOM
12782
CA
TRP
B
266
61.183
19.894
−22.484
1.00
19.27
B
C


ATOM
12784
CB
TRP
B
266
59.834
19.354
−22.972
1.00
19.17
B
C


ATOM
12787
CG
TRP
B
266
58.709
20.327
−22.879
1.00
19.53
B
C


ATOM
12788
CD1
TRP
B
266
57.867
20.512
−21.820
1.00
19.29
B
C


ATOM
12790
NE1
TRP
B
266
56.955
21.496
−22.107
1.00
18.94
B
N


ATOM
12792
CE2
TRP
B
266
57.190
21.963
−23.373
1.00
20.47
B
C


ATOM
12793
CD2
TRP
B
266
58.291
21.246
−23.891
1.00
21.23
B
C


ATOM
12794
CE3
TRP
B
266
58.742
21.537
−25.184
1.00
22.28
B
C


ATOM
12796
CZ3
TRP
B
266
58.087
22.520
−25.911
1.00
22.69
B
C


ATOM
12798
CH2
TRP
B
266
56.996
23.218
−25.367
1.00
22.30
B
C


ATOM
12800
CZ2
TRP
B
266
56.532
22.953
−24.105
1.00
20.82
B
C


ATOM
12802
C
TRP
B
266
61.069
20.374
−21.039
1.00
18.58
B
C


ATOM
12803
O
TRP
B
266
61.049
21.579
−20.779
1.00
18.53
B
O


ATOM
12805
N
ALA
B
267
61.003
19.422
−20.109
1.00
18.04
B
N


ATOM
12806
CA
ALA
B
267
60.846
19.721
−18.680
1.00
17.48
B
C


ATOM
12808
CB
ALA
B
267
60.644
18.432
−17.888
1.00
17.29
B
C


ATOM
12812
C
ALA
B
267
62.024
20.507
−18.111
1.00
16.68
B
C


ATOM
12813
O
ALA
B
267
61.834
21.408
−17.294
1.00
16.12
B
O


ATOM
12815
N
VAL
B
268
63.233
20.169
−18.556
1.00
16.04
B
N


ATOM
12816
CA
VAL
B
268
64.451
20.840
−18.094
1.00
15.90
B
C


ATOM
12818
CB
VAL
B
268
65.713
20.172
−18.685
1.00
15.88
B
C


ATOM
12820
CG1
VAL
B
268
65.880
18.777
−18.105
1.00
16.89
B
C


ATOM
12824
CG2
VAL
B
268
66.954
21.001
−18.414
1.00
14.94
B
C


ATOM
12828
C
VAL
B
268
64.444
22.339
−18.411
1.00
15.83
B
C


ATOM
12829
O
VAL
B
268
65.068
23.131
−17.707
1.00
15.84
B
O


ATOM
12831
N
GLY
B
269
63.736
22.725
−19.467
1.00
16.01
B
N


ATOM
12832
CA
GLY
B
269
63.520
24.136
−19.768
1.00
16.02
B
C


ATOM
12835
C
GLY
B
269
62.558
24.781
−18.788
1.00
15.89
B
C


ATOM
12836
O
GLY
B
269
62.710
25.952
−18.440
1.00
15.72
B
O


ATOM
12838
N
VAL
B
270
61.570
24.009
−18.341
1.00
15.89
B
N


ATOM
12839
CA
VAL
B
270
60.537
24.512
−17.439
1.00
15.75
B
C


ATOM
12841
CB
VAL
B
270
59.329
23.550
−17.364
1.00
15.72
B
C


ATOM
12843
CG1
VAL
B
270
58.227
24.145
−16.505
1.00
15.52
B
C


ATOM
12847
CG2
VAL
B
270
58.806
23.239
−18.759
1.00
15.42
B
C


ATOM
12851
C
VAL
B
270
61.098
24.728
−16.039
1.00
15.62
B
C


ATOM
12852
O
VAL
B
270
60.970
25.815
−15.481
1.00
15.95
B
O


ATOM
12854
N
ALA
B
271
61.724
23.692
−15.485
1.00
15.73
B
N


ATOM
12855
CA
ALA
B
271
62.301
23.756
−14.140
1.00
16.08
B
C


ATOM
12857
CB
ALA
B
271
61.403
23.033
−13.156
1.00
15.92
B
C


ATOM
12861
C
ALA
B
271
63.712
23.166
−14.108
1.00
16.48
B
C


ATOM
12862
O
ALA
B
271
63.898
21.987
−13.792
1.00
16.03
B
O


ATOM
12864
N
PHE
B
272
64.701
23.996
−14.435
1.00
17.15
B
N


ATOM
12865
CA
PHE
B
272
66.098
23.560
−14.476
1.00
17.81
B
C


ATOM
12867
CB
PHE
B
272
66.968
24.549
−15.268
1.00
18.10
B
C


ATOM
12870
CG
PHE
B
272
67.219
25.853
−14.557
1.00
19.12
B
C


ATOM
12871
CD1
PHE
B
272
68.266
25.978
−13.654
1.00
18.88
B
C


ATOM
12873
CE1
PHE
B
272
68.498
27.177
−12.995
1.00
20.29
B
C


ATOM
12875
CZ
PHE
B
272
67.688
28.273
−13.242
1.00
20.78
B
C


ATOM
12877
CE2
PHE
B
272
66.645
28.166
−14.146
1.00
21.63
B
C


ATOM
12879
CD2
PHE
B
272
66.414
26.960
−14.799
1.00
21.22
B
C


ATOM
12881
C
PHE
B
272
66.681
23.371
−13.082
1.00
18.23
B
C


ATOM
12882
O
PHE
B
272
67.510
22.486
−12.871
1.00
18.10
B
O


ATOM
12884
N
GLU
B
273
66.246
24.206
−12.138
1.00
18.89
B
N


ATOM
12885
CA
GLU
B
273
66.821
24.230
−10.792
1.00
19.04
B
C


ATOM
12887
CB
GLU
B
273
66.053
25.189
−9.870
1.00
19.05
B
C


ATOM
12890
CG
GLU
B
273
66.068
26.665
−10.295
1.00
19.59
B
C


ATOM
12893
CD
GLU
B
273
64.917
27.047
−11.222
1.00
22.44
B
C


ATOM
12894
OE1
GLU
B
273
64.464
28.210
−11.163
1.00
24.11
B
O


ATOM
12895
OE2
GLU
B
273
64.460
26.190
−12.009
1.00
24.79
B
O


ATOM
12896
C
GLU
B
273
66.826
22.809
−10.215
1.00
18.87
B
C


ATOM
12897
O
GLU
B
273
65.801
22.129
−10.257
1.00
19.19
B
O


ATOM
12899
N
PRO
B
274
67.985
22.349
−9.701
1.00
18.78
B
N


ATOM
12900
CA
PRO
B
274
68.155
20.957
−9.253
1.00
18.78
B
C


ATOM
12902
CB
PRO
B
274
69.478
20.999
−8.479
1.00
18.81
B
C


ATOM
12905
CG
PRO
B
274
70.229
22.113
−9.082
1.00
18.95
B
C


ATOM
12908
CD
PRO
B
274
69.231
23.127
−9.550
1.00
18.65
B
C


ATOM
12911
C
PRO
B
274
67.037
20.428
−8.351
1.00
18.44
B
C


ATOM
12912
O
PRO
B
274
66.501
19.347
−8.599
1.00
18.00
B
O


ATOM
12913
N
GLN
B
275
66.704
21.197
−7.320
1.00
18.53
B
N


ATOM
12914
CA
GLN
B
275
65.679
20.831
−6.339
1.00
18.90
B
C


ATOM
12916
CB
GLN
B
275
65.475
21.976
−5.332
1.00
19.10
B
C


ATOM
12919
CG
GLN
B
275
65.092
23.339
−5.936
1.00
19.30
B
C


ATOM
12922
CD
GLN
B
275
66.298
24.200
−6.290
1.00
19.15
B
C


ATOM
12923
OE1
GLN
B
275
67.237
23.734
−6.933
1.00
19.04
B
O


ATOM
12924
NE2
GLN
B
275
66.270
25.462
−5.877
1.00
19.96
B
N


ATOM
12927
C
GLN
B
275
64.318
20.404
−6.925
1.00
19.09
B
C


ATOM
12928
O
GLN
B
275
63.643
19.549
−6.347
1.00
19.14
B
O


ATOM
12930
N
TYR
B
276
63.924
20.979
−8.062
1.00
19.13
B
N


ATOM
12931
CA
TYR
B
276
62.625
20.672
−8.679
1.00
18.93
B
C


ATOM
12933
CB
TYR
B
276
62.170
21.817
−9.598
1.00
18.94
B
C


ATOM
12936
CG
TYR
B
276
62.067
23.177
−8.941
1.00
19.74
B
C


ATOM
12937
CD1
TYR
B
276
61.362
23.352
−7.755
1.00
20.43
B
C


ATOM
12939
CE1
TYR
B
276
61.263
24.600
−7.159
1.00
20.81
B
C


ATOM
12941
CZ
TYR
B
276
61.858
25.692
−7.759
1.00
20.24
B
C


ATOM
12942
OH
TYR
B
276
61.757
26.929
−7.173
1.00
23.88
B
O


ATOM
12944
CE2
TYR
B
276
62.551
25.550
−8.942
1.00
18.69
B
C


ATOM
12946
CD2
TYR
B
276
62.647
24.299
−9.529
1.00
19.51
B
C


ATOM
12948
C
TYR
B
276
62.646
19.371
−9.489
1.00
18.68
B
C


ATOM
12949
O
TYR
B
276
62.344
19.376
−10.681
1.00
18.82
B
O


ATOM
12951
N
SER
B
277
62.983
18.256
−8.848
1.00
18.35
B
N


ATOM
12952
CA
SER
B
277
62.984
16.961
−9.534
1.00
17.80
B
C


ATOM
12954
CB
SER
B
277
63.829
15.938
−8.774
1.00
17.69
B
C


ATOM
12957
OG
SER
B
277
65.212
16.219
−8.923
1.00
16.37
B
O


ATOM
12959
C
SER
B
277
61.558
16.449
−9.743
1.00
17.75
B
C


ATOM
12960
O
SER
B
277
61.257
15.869
−10.783
1.00
17.82
B
O


ATOM
12962
N
ASP
B
278
60.687
16.675
−8.761
1.00
17.90
B
N


ATOM
12963
CA
ASP
B
278
59.267
16.323
−8.881
1.00
17.97
B
C


ATOM
12965
CB
ASP
B
278
58.493
16.711
−7.618
1.00
18.01
B
C


ATOM
12968
CG
ASP
B
278
58.951
15.960
−6.390
1.00
18.66
B
C


ATOM
12969
OD1
ASP
B
278
59.518
14.860
−6.537
1.00
22.13
B
O


ATOM
12970
OD2
ASP
B
278
58.740
16.473
−5.271
1.00
20.36
B
O


ATOM
12971
C
ASP
B
278
58.620
17.019
−10.073
1.00
18.09
B
C


ATOM
12972
O
ASP
B
278
57.855
16.404
−10.813
1.00
18.35
B
O


ATOM
12974
N
CYS
B
279
58.919
18.303
−10.246
1.00
18.18
B
N


ATOM
12975
CA
CYS
B
279
58.366
19.077
−11.356
1.00
18.27
B
C


ATOM
12977
CB
CYS
B
279
58.847
20.538
−11.302
1.00
18.30
B
C


ATOM
12980
SG
CYS
B
279
57.937
21.699
−12.374
1.00
16.99
B
S


ATOM
12982
C
CYS
B
279
58.758
18.423
−12.676
1.00
18.44
B
C


ATOM
12983
O
CYS
B
279
57.897
18.121
−13.503
1.00
18.24
B
O


ATOM
12985
N
ARG
B
280
60.055
18.178
−12.846
1.00
18.78
B
N


ATOM
12986
CA
ARG
B
280
60.576
17.556
−14.063
1.00
18.99
B
C


ATOM
12988
CB
ARG
B
280
62.096
17.386
−13.978
1.00
19.18
B
C


ATOM
12991
CG
ARG
B
280
62.866
18.702
−14.057
1.00
20.22
B
C


ATOM
12994
CD
ARG
B
280
64.364
18.482
−14.244
1.00
20.99
B
C


ATOM
12997
NE
ARG
B
280
65.004
17.940
−13.047
1.00
20.45
B
N


ATOM
12999
CZ
ARG
B
280
65.341
18.652
−11.972
1.00
22.60
B
C


ATOM
13000
NH1
ARG
B
280
65.098
19.959
−11.908
1.00
22.84
B
N


ATOM
13003
NH2
ARG
B
280
65.923
18.046
−10.942
1.00
24.41
B
N


ATOM
13006
C
ARG
B
280
59.906
16.212
−14.339
1.00
18.84
B
C


ATOM
13007
O
ARG
B
280
59.427
15.973
−15.447
1.00
19.34
B
O


ATOM
13009
N
ASN
B
281
59.852
15.352
−13.326
1.00
18.40
B
N


ATOM
13010
CA
ASN
B
281
59.227
14.034
−13.468
1.00
18.38
B
C


ATOM
13012
CB
ASN
B
281
59.559
13.146
−12.266
1.00
18.31
B
C


ATOM
13015
CG
ASN
B
281
61.055
12.921
−12.103
1.00
19.38
B
C


ATOM
13016
OD1
ASN
B
281
61.851
13.291
−12.969
1.00
18.81
B
O


ATOM
13017
ND2
ASN
B
281
61.445
12.317
−10.985
1.00
21.51
B
N


ATOM
13020
C
ASN
B
281
57.710
14.109
−13.672
1.00
18.30
B
C


ATOM
13021
O
ASN
B
281
57.126
13.240
−14.317
1.00
18.27
B
O


ATOM
13023
N
SER
B
282
57.078
15.150
−13.132
1.00
17.93
B
N


ATOM
13024
CA
SER
B
282
55.651
15.378
−13.352
1.00
17.39
B
C


ATOM
13026
CB
SER
B
282
55.106
16.395
−12.340
1.00
17.68
B
C


ATOM
13029
OG
SER
B
282
53.687
16.431
−12.343
1.00
18.53
B
O


ATOM
13031
C
SER
B
282
55.410
15.861
−14.786
1.00
16.41
B
C


ATOM
13032
O
SER
B
282
54.649
15.251
−15.535
1.00
15.72
B
O


ATOM
13034
N
VAL
B
283
56.083
16.944
−15.167
1.00
15.82
B
N


ATOM
13035
CA
VAL
B
283
55.893
17.546
−16.489
1.00
15.38
B
C


ATOM
13037
CB
VAL
B
283
56.678
18.871
−16.635
1.00
15.03
B
C


ATOM
13039
CG1
VAL
B
283
56.610
19.388
−18.066
1.00
13.71
B
C


ATOM
13043
CG2
VAL
B
283
56.136
19.912
−15.669
1.00
13.54
B
C


ATOM
13047
C
VAL
B
283
56.289
16.584
−17.607
1.00
15.75
B
C


ATOM
13048
O
VAL
B
283
55.608
16.504
−18.627
1.00
15.73
B
O


ATOM
13050
N
ALA
B
284
57.381
15.852
−17.410
1.00
16.23
B
N


ATOM
13051
CA
ALA
B
284
57.811
14.857
−18.387
1.00
16.83
B
C


ATOM
13053
CB
ALA
B
284
59.098
14.185
−17.939
1.00
16.69
B
C


ATOM
13057
C
ALA
B
284
56.713
13.818
−18.592
1.00
17.70
B
C


ATOM
13058
O
ALA
B
284
56.235
13.629
−19.712
1.00
17.70
B
O


ATOM
13060
N
LYS
B
285
56.311
13.170
−17.497
1.00
18.64
B
N


ATOM
13061
CA
LYS
B
285
55.259
12.146
−17.518
1.00
18.83
B
C


ATOM
13063
CB
LYS
B
285
54.860
11.750
−16.089
1.00
18.82
B
C


ATOM
13066
CG
LYS
B
285
55.795
10.749
−15.431
1.00
20.25
B
C


ATOM
13069
CD
LYS
B
285
55.419
10.498
−13.974
1.00
22.25
B
C


ATOM
13072
CE
LYS
B
285
56.438
9.597
−13.279
1.00
23.50
B
C


ATOM
13075
NZ
LYS
B
285
56.327
9.653
−11.792
1.00
23.56
B
N


ATOM
13079
C
LYS
B
285
54.015
12.604
−18.274
1.00
18.88
B
C


ATOM
13080
O
LYS
B
285
53.524
11.895
−19.151
1.00
18.86
B
O


ATOM
13082
N
MET
B
286
53.518
13.790
−17.932
1.00
19.06
B
N


ATOM
13083
CA
MET
B
286
52.272
14.299
−18.506
1.00
19.32
B
C


ATOM
13085
CB
MET
B
286
51.853
15.601
−17.818
1.00
19.40
B
C


ATOM
13088
CG
MET
B
286
51.483
15.460
−16.350
1.00
19.99
B
C


ATOM
13091
SD
MET
B
286
50.219
14.220
−16.032
1.00
21.41
B
S


ATOM
13092
CE
MET
B
286
51.231
12.784
−15.666
1.00
21.45
B
C


ATOM
13096
C
MET
B
286
52.379
14.535
−20.010
1.00
19.39
B
C


ATOM
13097
O
MET
B
286
51.486
14.152
−20.769
1.00
19.62
B
O


ATOM
13099
N
PHE
B
287
53.474
15.163
−20.429
1.00
19.05
B
N


ATOM
13100
CA
PHE
B
287
53.684
15.501
−21.835
1.00
18.49
B
C


ATOM
13102
CB
PHE
B
287
54.845
16.499
−21.969
1.00
18.88
B
C


ATOM
13105
CG
PHE
B
287
54.942
17.161
−23.320
1.00
19.92
B
C


ATOM
13106
CD1
PHE
B
287
53.805
17.632
−23.977
1.00
20.75
B
C


ATOM
13108
CE1
PHE
B
287
53.899
18.243
−25.217
1.00
20.58
B
C


ATOM
13110
CZ
PHE
B
287
55.136
18.405
−25.812
1.00
23.37
B
C


ATOM
13112
CE2
PHE
B
287
56.280
17.952
−25.165
1.00
23.28
B
C


ATOM
13114
CD2
PHE
B
287
56.178
17.338
−23.925
1.00
21.35
B
C


ATOM
13116
C
PHE
B
287
53.919
14.250
−22.690
1.00
17.56
B
C


ATOM
13117
O
PHE
B
287
53.564
14.231
−23.869
1.00
17.16
B
O


ATOM
13119
N
SER
B
288
54.503
13.209
−22.096
1.00
16.87
B
N


ATOM
13120
CA
SER
B
288
54.594
11.903
−22.757
1.00
16.53
B
C


ATOM
13122
CB
SER
B
288
55.368
10.891
−21.904
1.00
16.55
B
C


ATOM
13125
OG
SER
B
288
56.768
11.116
−21.970
1.00
16.74
B
O


ATOM
13127
C
SER
B
288
53.195
11.374
−23.045
1.00
16.36
B
C


ATOM
13128
O
SER
B
288
52.902
10.956
−24.165
1.00
16.74
B
O


ATOM
13130
N
PHE
B
289
52.331
11.406
−22.034
1.00
16.08
B
N


ATOM
13131
CA
PHE
B
289
50.930
11.029
−22.214
1.00
15.77
B
C


ATOM
13133
CB
PHE
B
289
50.171
11.038
−20.878
1.00
15.73
B
C


ATOM
13136
CG
PHE
B
289
50.321
9.767
−20.087
1.00
16.79
B
C


ATOM
13137
CD1
PHE
B
289
49.832
8.564
−20.585
1.00
18.35
B
C


ATOM
13139
CE1
PHE
B
289
49.966
7.384
−19.864
1.00
17.92
B
C


ATOM
13141
CZ
PHE
B
289
50.591
7.399
−18.628
1.00
18.05
B
C


ATOM
13143
CE2
PHE
B
289
51.081
8.591
−18.119
1.00
18.22
B
C


ATOM
13145
CD2
PHE
B
289
50.943
9.768
−18.846
1.00
17.63
B
C


ATOM
13147
C
PHE
B
289
50.225
11.930
−23.229
1.00
15.42
B
C


ATOM
13148
O
PHE
B
289
49.437
11.445
−24.039
1.00
15.46
B
O


ATOM
13150
N
VAL
B
290
50.517
13.230
−23.193
1.00
15.19
B
N


ATOM
13151
CA
VAL
B
290
49.908
14.179
−24.133
1.00
14.81
B
C


ATOM
13153
CB
VAL
B
290
50.383
15.639
−23.905
1.00
14.27
B
C


ATOM
13155
CG1
VAL
B
290
49.790
16.565
−24.954
1.00
11.43
B
C


ATOM
13159
CG2
VAL
B
290
50.002
16.118
−22.521
1.00
13.72
B
C


ATOM
13163
C
VAL
B
290
50.194
13.784
−25.583
1.00
15.49
B
C


ATOM
13164
O
VAL
B
290
49.276
13.740
−26.402
1.00
15.62
B
O


ATOM
13166
N
THR
B
291
51.455
13.476
−25.893
1.00
15.62
B
N


ATOM
13167
CA
THR
B
291
51.838
13.155
−27.273
1.00
15.90
B
C


ATOM
13169
CB
THR
B
291
53.367
12.948
−27.445
1.00
15.92
B
C


ATOM
13171
OG1
THR
B
291
53.781
11.762
−26.759
1.00
17.87
B
O


ATOM
13173
CG2
THR
B
291
54.150
14.145
−26.917
1.00
16.50
B
C


ATOM
13177
C
THR
B
291
51.109
11.914
−27.786
1.00
15.66
B
C


ATOM
13178
O
THR
B
291
50.809
11.818
−28.977
1.00
15.78
B
O


ATOM
13180
N
ILE
B
292
50.824
10.977
−26.882
1.00
15.54
B
N


ATOM
13181
CA
ILE
B
292
50.114
9.743
−27.228
1.00
15.38
B
C


ATOM
13183
CB
ILE
B
292
50.331
8.650
−26.160
1.00
15.32
B
C


ATOM
13185
CG1
ILE
B
292
51.803
8.234
−26.129
1.00
13.86
B
C


ATOM
13188
CD1
ILE
B
292
52.103
7.171
−25.111
1.00
13.47
B
C


ATOM
13192
CG2
ILE
B
292
49.446
7.434
−26.437
1.00
15.16
B
C


ATOM
13196
C
ILE
B
292
48.612
9.978
−27.426
1.00
15.28
B
C


ATOM
13197
O
ILE
B
292
48.023
9.462
−28.379
1.00
15.27
B
O


ATOM
13199
N
ILE
B
293
47.997
10.749
−26.531
1.00
14.89
B
N


ATOM
13200
CA
ILE
B
293
46.580
11.079
−26.672
1.00
14.80
B
C


ATOM
13202
CB
ILE
B
293
46.012
11.832
−25.453
1.00
14.64
B
C


ATOM
13204
CG1
ILE
B
293
46.094
10.979
−24.184
1.00
14.55
B
C


ATOM
13207
CD1
ILE
B
293
45.101
9.846
−24.144
1.00
14.32
B
C


ATOM
13211
CG2
ILE
B
293
44.558
12.203
−25.700
1.00
14.22
B
C


ATOM
13215
C
ILE
B
293
46.394
11.938
−27.916
1.00
15.23
B
C


ATOM
13216
O
ILE
B
293
45.466
11.724
−28.691
1.00
15.35
B
O


ATOM
13218
N
ASP
B
294
47.291
12.901
−28.110
1.00
15.94
B
N


ATOM
13219
CA
ASP
B
294
47.273
13.739
−29.313
1.00
16.55
B
C


ATOM
13221
CB
ASP
B
294
48.491
14.682
−29.346
1.00
17.12
B
C


ATOM
13224
CG
ASP
B
294
48.314
15.858
−30.307
1.00
17.49
B
C


ATOM
13225
OD1
ASP
B
294
47.164
16.220
−30.634
1.00
17.71
B
O


ATOM
13226
OD2
ASP
B
294
49.342
16.437
−30.720
1.00
18.55
B
O


ATOM
13227
C
ASP
B
294
47.239
12.861
−30.564
1.00
16.11
B
C


ATOM
13228
O
ASP
B
294
46.495
13.144
−31.495
1.00
16.16
B
O


ATOM
13230
N
ASP
B
295
48.029
11.788
−30.567
1.00
15.75
B
N


ATOM
13231
CA
ASP
B
295
48.006
10.816
−31.663
1.00
15.80
B
C


ATOM
13233
CB
ASP
B
295
49.092
9.750
−31.481
1.00
15.85
B
C


ATOM
13236
CG
ASP
B
295
50.462
10.218
−31.932
1.00
15.72
B
C


ATOM
13237
OD1
ASP
B
295
50.570
11.306
−32.536
1.00
16.90
B
O


ATOM
13238
OD2
ASP
B
295
51.440
9.486
−31.684
1.00
13.67
B
O


ATOM
13239
C
ASP
B
295
46.650
10.132
−31.797
1.00
15.95
B
C


ATOM
13240
O
ASP
B
295
46.149
9.960
−32.911
1.00
16.24
B
O


ATOM
13242
N
ILE
B
296
46.063
9.738
−30.668
1.00
15.64
B
N


ATOM
13243
CA
ILE
B
296
44.754
9.080
−30.674
1.00
15.06
B
C


ATOM
13245
CB
ILE
B
296
44.270
8.738
−29.251
1.00
14.85
B
C


ATOM
13247
CG1
ILE
B
296
45.067
7.558
−28.699
1.00
14.95
B
C


ATOM
13250
CD1
ILE
B
296
44.747
7.211
−27.266
1.00
15.45
B
C


ATOM
13254
CG2
ILE
B
296
42.795
8.378
−29.263
1.00
15.55
B
C


ATOM
13258
C
ILE
B
296
43.696
9.932
−31.365
1.00
14.52
B
C


ATOM
13259
O
ILE
B
296
43.010
9.462
−32.269
1.00
14.11
B
O


ATOM
13261
N
TYR
B
297
43.579
11.185
−30.941
1.00
14.55
B
N


ATOM
13262
CA
TYR
B
297
42.557
12.089
−31.471
1.00
14.75
B
C


ATOM
13264
CB
TYR
B
297
42.392
13.311
−30.558
1.00
14.65
B
C


ATOM
13267
CG
TYR
B
297
41.605
13.051
−29.288
1.00
13.97
B
C


ATOM
13268
CD1
TYR
B
297
40.311
13.543
−29.132
1.00
15.04
B
C


ATOM
13270
CE1
TYR
B
297
39.586
13.315
−27.963
1.00
15.12
B
C


ATOM
13272
CZ
TYR
B
297
40.157
12.584
−26.938
1.00
16.10
B
C


ATOM
13273
OH
TYR
B
297
39.452
12.349
−25.781
1.00
17.13
B
O


ATOM
13275
CE2
TYR
B
297
41.439
12.086
−27.070
1.00
16.03
B
C


ATOM
13277
CD2
TYR
B
297
42.156
12.322
−28.240
1.00
15.06
B
C


ATOM
13279
C
TYR
B
297
42.869
12.545
−32.898
1.00
14.81
B
C


ATOM
13280
O
TYR
B
297
41.995
12.524
−33.770
1.00
14.70
B
O


ATOM
13282
N
ASP
B
298
44.117
12.946
−33.125
1.00
14.76
B
N


ATOM
13283
CA
ASP
B
298
44.529
13.551
−34.391
1.00
14.85
B
C


ATOM
13285
CB
ASP
B
298
46.011
13.965
−34.327
1.00
15.56
B
C


ATOM
13288
CG
ASP
B
298
46.436
14.845
−35.495
1.00
16.94
B
C


ATOM
13289
OD1
ASP
B
298
45.717
15.822
−35.798
1.00
19.66
B
O


ATOM
13290
OD2
ASP
B
298
47.500
14.571
−36.096
1.00
16.83
B
O


ATOM
13291
C
ASP
B
298
44.298
12.621
−35.579
1.00
13.99
B
C


ATOM
13292
O
ASP
B
298
43.653
13.011
−36.552
1.00
13.35
B
O


ATOM
13294
N
VAL
B
299
44.813
11.395
−35.487
1.00
13.69
B
N


ATOM
13295
CA
VAL
B
299
44.819
10.467
−36.629
1.00
13.50
B
C


ATOM
13297
CB
VAL
B
299
46.263
10.201
−37.129
1.00
13.48
B
C


ATOM
13299
CG1
VAL
B
299
46.901
11.491
−37.614
1.00
14.14
B
C


ATOM
13303
CG2
VAL
B
299
47.111
9.556
−36.038
1.00
13.60
B
C


ATOM
13307
C
VAL
B
299
44.139
9.112
−36.404
1.00
12.90
B
C


ATOM
13308
O
VAL
B
299
43.543
8.574
−37.336
1.00
12.78
B
O


ATOM
13310
N
TYR
B
300
44.217
8.563
−35.192
1.00
12.41
B
N


ATOM
13311
CA
TYR
B
300
43.884
7.149
−34.976
1.00
12.41
B
C


ATOM
13313
CB
TYR
B
300
44.802
6.549
−33.911
1.00
12.27
B
C


ATOM
13316
CG
TYR
B
300
44.709
5.041
−33.826
1.00
12.47
B
C


ATOM
13317
CD1
TYR
B
300
45.090
4.241
−34.898
1.00
11.58
B
C


ATOM
13319
CE1
TYR
B
300
45.005
2.858
−34.831
1.00
10.77
B
C


ATOM
13321
CZ
TYR
B
300
44.535
2.258
−33.681
1.00
10.71
B
C


ATOM
13322
OH
TYR
B
300
44.451
O.888
−33.608
1.00
11.57
B
O


ATOM
13324
CE2
TYR
B
300
44.150
3.027
−32.602
1.00
13.01
B
C


ATOM
13326
CD2
TYR
B
300
44.237
4.415
−32.679
1.00
13.92
B
C


ATOM
13328
C
TYR
B
300
42.420
6.833
−34.624
1.00
12.63
B
C


ATOM
13329
O
TYR
B
300
41.804
5.979
−35.259
1.00
12.91
B
O


ATOM
13331
N
GLY
B
301
41.869
7.496
−33.614
1.00
12.74
B
N


ATOM
13332
CA
GLY
B
301
40.531
7.156
−33.118
1.00
12.64
B
C


ATOM
13335
C
GLY
B
301
39.382
7.678
−33.966
1.00
12.49
B
C


ATOM
13336
O
GLY
B
301
39.498
8.719
−34.613
1.00
12.57
B
O


ATOM
13338
N
THR
B
302
38.265
6.951
−33.957
1.00
12.36
B
N


ATOM
13339
CA
THR
B
302
37.033
7.433
−34.579
1.00
12.60
B
C


ATOM
13341
CB
THR
B
302
36.010
6.307
−34.834
1.00
12.31
B
C


ATOM
13343
OG1
THR
B
302
35.511
5.810
−33.587
1.00
11.75
B
O


ATOM
13345
CG2
THR
B
302
36.631
5.171
−35.624
1.00
12.44
B
C


ATOM
13349
C
THR
B
302
36.391
8.449
−33.653
1.00
13.44
B
C


ATOM
13350
O
THR
B
302
36.764
8.556
−32.487
1.00
13.63
B
O


ATOM
13352
N
LEU
B
303
35.408
9.181
−34.166
1.00
14.23
B
N


ATOM
13353
CA
LEU
B
303
34.732
10.205
−33.373
1.00
14.47
B
C


ATOM
13355
CB
LEU
B
303
33.758
11.004
−34.239
1.00
14.69
B
C


ATOM
13358
CG
LEU
B
303
33.460
12.428
−33.775
1.00
14.65
B
C


ATOM
13360
CD1
LEU
B
303
34.684
13.310
−33.959
1.00
13.80
B
C


ATOM
13364
CD2
LEU
B
303
32.268
12.988
−34.544
1.00
16.81
B
C


ATOM
13368
C
LEU
B
303
33.998
9.573
−32.192
1.00
14.67
B
C


ATOM
13369
O
LEU
B
303
34.065
10.082
−31.075
1.00
14.67
B
O


ATOM
13371
N
ASP
B
304
33.311
8.460
−32.449
1.00
15.27
B
N


ATOM
13372
CA
ASP
B
304
32.630
7.694
−31.395
1.00
15.80
B
C


ATOM
13374
CB
ASP
B
304
31.828
6.523
−31.991
1.00
16.12
B
C


ATOM
13377
CG
ASP
B
304
30.537
6.966
−32.668
1.00
16.23
B
C


ATOM
13378
OD1
ASP
B
304
30.252
8.183
−32.707
1.00
17.00
B
O


ATOM
13379
OD2
ASP
B
304
29.803
6.086
−33.165
1.00
15.17
B
O


ATOM
13380
C
ASP
B
304
33.617
7.155
−30.356
1.00
15.75
B
C


ATOM
13381
O
ASP
B
304
33.332
7.168
−29.154
1.00
15.68
B
O


ATOM
13383
N
GLU
B
305
34.765
6.669
−30.823
1.00
15.44
B
N


ATOM
13384
CA
GLU
B
305
35.823
6.207
−29.926
1.00
15.31
B
C


ATOM
13386
CB
GLU
B
305
36.965
5.564
−30.713
1.00
15.57
B
C


ATOM
13389
CG
GLU
B
305
36.689
4.138
−31.162
1.00
15.98
B
C


ATOM
13392
CD
GLU
B
305
37.800
3.581
−32.027
1.00
16.46
B
C


ATOM
13393
OE1
GLU
B
305
38.399
4.350
−32.807
1.00
17.84
B
O


ATOM
13394
OE2
GLU
B
305
38.076
2.369
−31.936
1.00
17.97
B
O


ATOM
13395
C
GLU
B
305
36.366
7.357
−29.088
1.00
15.04
B
C


ATOM
13396
O
GLU
B
305
36.621
7.190
−27.895
1.00
15.15
B
O


ATOM
13398
N
LEU
B
306
36.536
8.518
−29.720
1.00
14.77
B
N


ATOM
13399
CA
LEU
B
306
37.040
9.715
−29.040
1.00
13.94
B
C


ATOM
13401
CB
LEU
B
306
37.447
10.778
−30.064
1.00
13.32
B
C


ATOM
13404
CG
LEU
B
306
38.667
10.392
−30.903
1.00
11.95
B
C


ATOM
13406
CD1
LEU
B
306
38.892
11.372
−32.041
1.00
9.49
B
C


ATOM
13410
CD2
LEU
B
306
39.897
10.287
−30.018
1.00
12.30
B
C


ATOM
13414
C
LEU
B
306
36.024
10.283
−28.050
1.00
14.05
B
C


ATOM
13415
O
LEU
B
306
36.405
10.817
−27.007
1.00
13.84
B
O


ATOM
13417
N
GLU
B
307
34.739
10.159
−28.374
1.00
14.32
B
N


ATOM
13418
CA
GLU
B
307
33.672
10.542
−27.448
1.00
14.91
B
C


ATOM
13420
CB
GLU
B
307
32.296
10.437
−28.119
1.00
15.01
B
C


ATOM
13423
CG
GLU
B
307
31.885
11.687
−28.890
1.00
16.39
B
C


ATOM
13426
CD
GLU
B
307
31.587
12.875
−27.985
1.00
18.17
B
C


ATOM
13427
OE1
GLU
B
307
31.715
14.025
−28.455
1.00
18.84
B
O


ATOM
13428
OE2
GLU
B
307
31.227
12.662
−26.805
1.00
19.10
B
O


ATOM
13429
C
GLU
B
307
33.695
9.709
−26.164
1.00
15.05
B
C


ATOM
13430
O
GLU
B
307
33.545
10.256
−25.070
1.00
15.50
B
O


ATOM
13432
N
LEU
B
308
33.883
8.395
−26.299
1.00
14.90
B
N


ATOM
13433
CA
LEU
B
308
33.941
7.501
−25.136
1.00
14.90
B
C


ATOM
13435
CB
LEU
B
308
33.975
6.027
−25.562
1.00
15.03
B
C


ATOM
13438
CG
LEU
B
308
32.705
5.409
−26.151
1.00
15.09
B
C


ATOM
13440
CD1
LEU
B
308
32.922
3.918
−26.391
1.00
12.37
B
C


ATOM
13444
CD2
LEU
B
308
31.503
5.640
−25.244
1.00
14.58
B
C


ATOM
13448
C
LEU
B
308
35.144
7.794
−24.244
1.00
14.76
B
C


ATOM
13449
O
LEU
B
308
35.047
7.693
−23.023
1.00
14.83
B
O


ATOM
13451
N
PHE
B
309
36.272
8.148
−24.854
1.00
14.97
B
N


ATOM
13452
CA
PHE
B
309
37.482
8.481
−24.102
1.00
15.23
B
C


ATOM
13454
CB
PHE
B
309
38.701
8.540
−25.030
1.00
14.93
B
C


ATOM
13457
CG
PHE
B
309
40.014
8.476
−24.303
1.00
12.81
B
C


ATOM
13458
CD1
PHE
B
309
40.712
7.280
−24.213
1.00
10.56
B
C


ATOM
13460
CE1
PHE
B
309
41.919
7.212
−23.537
1.00
9.68
B
C


ATOM
13462
CZ
PHE
B
309
42.440
8.345
−22.941
1.00
10.55
B
C


ATOM
13464
CE2
PHE
B
309
41.752
9.550
−23.020
1.00
11.50
B
C


ATOM
13466
CD2
PHE
B
309
40.547
9.610
−23.698
1.00
11.86
B
C


ATOM
13468
C
PHE
B
309
37.318
9.815
−23.361
1.00
16.02
B
C


ATOM
13469
O
PHE
B
309
37.597
9.905
−22.162
1.00
16.16
B
O


ATOM
13471
N
THR
B
310
36.876
10.843
−24.083
1.00
16.42
B
N


ATOM
13472
CA
THR
B
310
36.594
12.144
−23.484
1.00
16.93
B
C


ATOM
13474
CB
THR
B
310
35.941
13.101
−24.499
1.00
17.11
B
C


ATOM
13476
OG1
THR
B
310
36.753
13.182
−25.676
1.00
18.04
B
O


ATOM
13478
CG2
THR
B
310
35.775
14.490
−23.898
1.00
17.27
B
C


ATOM
13482
C
THR
B
310
35.645
11.970
−22.306
1.00
17.22
B
C


ATOM
13483
O
THR
B
310
35.893
12.475
−21.213
1.00
17.31
B
O


ATOM
13485
N
ASP
B
311
34.560
11.242
−22.549
1.00
17.64
B
N


ATOM
13486
CA
ASP
B
311
33.559
10.957
−21.529
1.00
18.02
B
C


ATOM
13488
CB
ASP
B
311
32.432
10.119
−22.136
1.00
17.98
B
C


ATOM
13491
CG
ASP
B
311
31.441
9.638
−21.103
1.00
18.70
B
C


ATOM
13492
OD1
ASP
B
311
30.851
10.486
−20.399
1.00
19.29
B
O


ATOM
13493
OD2
ASP
B
311
31.251
8.407
−20.997
1.00
21.03
B
O


ATOM
13494
C
ASP
B
311
34.160
10.228
−20.326
1.00
18.33
B
C


ATOM
13495
O
ASP
B
311
33.934
10.624
−19.182
1.00
18.39
B
O


ATOM
13497
N
ALA
B
312
34.925
9.170
−20.597
1.00
18.50
B
N


ATOM
13498
CA
ALA
B
312
35.524
8.335
−19.548
1.00
18.23
B
C


ATOM
13500
CB
ALA
B
312
36.268
7.159
−20.168
1.00
18.14
B
C


ATOM
13504
C
ALA
B
312
36.456
9.117
−18.625
1.00
18.16
B
C


ATOM
13505
O
ALA
B
312
36.513
8.845
−17.426
1.00
18.48
B
O


ATOM
13507
N
VAL
B
313
37.183
10.079
−19.189
1.00
18.03
B
N


ATOM
13508
CA
VAL
B
313
38.050
10.960
−18.405
1.00
18.31
B
C


ATOM
13510
CB
VAL
B
313
38.965
11.805
−19.326
1.00
18.52
B
C


ATOM
13512
CG1
VAL
B
313
40.105
10.946
−19.870
1.00
18.57
B
C


ATOM
13516
CG2
VAL
B
313
39.515
13.021
−18.588
1.00
18.51
B
C


ATOM
13520
C
VAL
B
313
37.240
11.882
−17.486
1.00
18.58
B
C


ATOM
13521
O
VAL
B
313
37.553
12.016
−16.303
1.00
18.04
B
O


ATOM
13523
N
GLU
B
314
36.198
12.504
−18.033
1.00
19.37
B
N


ATOM
13524
CA
GLU
B
314
35.321
13.395
−17.258
1.00
20.06
B
C


ATOM
13526
CB
GLU
B
314
34.224
13.987
−18.154
1.00
20.50
B
C


ATOM
13529
CG
GLU
B
314
34.697
15.089
−19.102
1.00
21.76
B
C


ATOM
13532
CD
GLU
B
314
33.609
15.550
−20.064
1.00
23.96
B
C


ATOM
13533
OE1
GLU
B
314
33.914
16.363
−20.962
1.00
23.97
B
O


ATOM
13534
OE2
GLU
B
314
32.449
15.100
−19.929
1.00
25.34
B
O


ATOM
13535
C
GLU
B
314
34.667
12.709
−16.053
1.00
19.90
B
C


ATOM
13536
O
GLU
B
314
34.342
13.369
−15.068
1.00
20.36
B
O


ATOM
13538
N
ARG
B
315
34.463
11.398
−16.141
1.00
19.78
B
N


ATOM
13539
CA
ARG
B
315
33.863
10.626
−15.054
1.00
20.09
B
C


ATOM
13541
CB
ARG
B
315
33.116
9.420
−15.616
1.00
20.83
B
C


ATOM
13544
CG
ARG
B
315
31.940
9.789
−16.488
1.00
23.42
B
C


ATOM
13547
CD
ARG
B
315
31.282
8.560
−17.080
1.00
27.26
B
C


ATOM
13550
NE
ARG
B
315
30.102
8.922
−17.863
1.00
32.39
B
N


ATOM
13552
CZ
ARG
B
315
28.915
9.250
−17.351
1.00
35.04
B
C


ATOM
13553
NH1
ARG
B
315
28.712
9.262
−16.035
1.00
36.54
B
N


ATOM
13556
NH2
ARG
B
315
27.914
9.567
−18.168
1.00
34.69
B
N


ATOM
13559
C
ARG
B
315
34.901
10.145
−14.049
1.00
19.51
B
C


ATOM
13560
O
ARG
B
315
34.642
10.126
−12.845
1.00
19.73
B
O


ATOM
13562
N
TRP
B
316
36.065
9.741
−14.553
1.00
18.77
B
N


ATOM
13563
CA
TRP
B
316
37.150
9.218
−13.725
1.00
17.72
B
C


ATOM
13565
CB
TRP
B
316
37.694
10.308
−12.794
1.00
17.03
B
C


ATOM
13568
CG
TRP
B
316
39.112
10.081
−12.398
1.00
14.29
B
C


ATOM
13569
CD1
TRP
B
316
39.566
9.639
−11.195
1.00
13.02
B
C


ATOM
13571
NE1
TRP
B
316
40.934
9.547
−11.211
1.00
12.01
B
N


ATOM
13573
CE2
TRP
B
316
41.389
9.930
−12.443
1.00
11.63
B
C


ATOM
13574
CD2
TRP
B
316
40.267
10.271
−13.218
1.00
12.10
B
C


ATOM
13575
CE3
TRP
B
316
40.462
10.702
−14.533
1.00
13.74
B
C


ATOM
13577
CZ3
TRP
B
316
41.752
10.778
−15.024
1.00
13.08
B
C


ATOM
13579
CH2
TRP
B
316
42.848
10.432
−14.228
1.00
13.51
B
C


ATOM
13581
CZ2
TRP
B
316
42.688
10.004
−12.937
1.00
13.12
B
C


ATOM
13583
C
TRP
B
316
36.678
7.995
−12.940
1.00
17.90
B
C


ATOM
13584
O
TRP
B
316
36.859
7.909
−11.727
1.00
17.86
B
O


ATOM
13586
N
ASP
B
317
36.073
7.053
−13.658
1.00
18.19
B
N


ATOM
13587
CA
ASP
B
317
35.487
5.863
−13.057
1.00
18.63
B
C


ATOM
13589
CB
ASP
B
317
33.983
5.825
−13.354
1.00
18.49
B
C


ATOM
13592
CG
ASP
B
317
33.270
4.671
−12.664
1.00
18.45
B
C


ATOM
13593
OD1
ASP
B
317
33.789
4.140
−11.659
1.00
17.90
B
O


ATOM
13594
OD2
ASP
B
317
32.173
4.298
−13.129
1.00
19.26
B
O


ATOM
13595
C
ASP
B
317
36.177
4.618
−13.605
1.00
19.33
B
C


ATOM
13596
O
ASP
B
317
35.899
4.186
−14.723
1.00
19.83
B
O


ATOM
13598
N
VAL
B
318
37.072
4.040
−12.808
1.00
20.11
B
N


ATOM
13599
CA
VAL
B
318
37.836
2.857
−13.222
1.00
20.65
B
C


ATOM
13601
CB
VAL
B
318
38.983
2.555
−12.231
1.00
20.75
B
C


ATOM
13603
CG1
VAL
B
318
40.006
1.618
−12.859
1.00
20.37
B
C


ATOM
13607
CG2
VAL
B
318
38.434
1.984
−10.929
1.00
21.89
B
C


ATOM
13611
C
VAL
B
318
36.973
1.601
−13.381
1.00
21.11
B
C


ATOM
13612
O
VAL
B
318
37.433
0.607
−13.938
1.00
21.49
B
O


ATOM
13614
N
ASN
B
319
35.739
1.640
−12.879
1.00
21.87
B
N


ATOM
13615
CA
ASN
B
319
34.769
0.561
−13.103
1.00
22.19
B
C


ATOM
13617
CB
ASN
B
319
33.661
0.605
−12.049
1.00
22.01
B
C


ATOM
13620
CG
ASN
B
319
34.184
0.354
−10.645
1.00
23.10
B
C


ATOM
13621
OD1
ASN
B
319
34.633
−0.747
−10.323
1.00
24.06
B
O


ATOM
13622
ND2
ASN
B
319
34.126
1.379
−9.801
1.00
22.91
B
N


ATOM
13625
C
ASN
B
319
34.157
0.624
−14.503
1.00
22.52
B
C


ATOM
13626
O
ASN
B
319
33.797
−0.407
−15.071
1.00
22.62
B
O


ATOM
13628
N
ALA
B
320
34.057
1.833
−15.057
1.00
22.93
B
N


ATOM
13629
CA
ALA
B
320
33.528
2.040
−16.411
1.00
23.46
B
C


ATOM
13631
CB
ALA
B
320
32.801
3.381
−16.485
1.00
23.82
B
C


ATOM
13635
C
ALA
B
320
34.615
1.966
−17.495
1.00
23.78
B
C


ATOM
13636
O
ALA
B
320
34.456
2.528
−18.579
1.00
23.85
B
O


ATOM
13638
N
ILE
B
321
35.714
1.275
−17.197
1.00
24.14
B
N


ATOM
13639
CA
ILE
B
321
36.796
1.063
−18.159
1.00
23.92
B
C


ATOM
13641
CB
ILE
B
321
38.086
0.529
−17.457
1.00
24.05
B
C


ATOM
13643
CG1
ILE
B
321
39.279
0.540
−18.416
1.00
23.88
B
C


ATOM
13646
CD1
ILE
B
321
40.563
0.038
−17.785
1.00
24.06
B
C


ATOM
13650
CG2
ILE
B
321
37.873
−0.878
−16.884
1.00
23.28
B
C


ATOM
13654
C
ILE
B
321
36.356
0.103
−19.267
1.00
23.68
B
C


ATOM
13655
O
ILE
B
321
36.578
0.379
−20.445
1.00
23.41
B
O


ATOM
13657
N
ASN
B
322
35.706
−0.999
−18.882
1.00
23.66
B
N


ATOM
13658
CA
ASN
B
322
35.280
−2.050
−19.823
1.00
23.61
B
C


ATOM
13660
CB
ASN
B
322
34.503
−3.165
−19.093
1.00
23.73
B
C


ATOM
13663
CG
ASN
B
322
35.413
−4.227
−18.468
1.00
23.75
B
C


ATOM
13664
OD1
ASN
B
322
36.561
−4.414
−18.877
1.00
23.33
B
O


ATOM
13665
ND2
ASN
B
322
34.885
−4.939
−17.479
1.00
22.49
B
N


ATOM
13668
C
ASN
B
322
34.434
−1.539
−20.992
1.00
23.44
B
C


ATOM
13669
O
ASN
B
322
34.330
−2.207
−22.021
1.00
23.62
B
O


ATOM
13671
N
ASP
B
323
33.828
−0.365
−20.826
1.00
23.09
B
N


ATOM
13672
CA
ASP
B
323
33.050
0.269
−21.889
1.00
22.51
B
C


ATOM
13674
CB
ASP
B
323
32.249
1.458
−21.328
1.00
23.08
B
C


ATOM
13677
CG
ASP
B
323
31.293
1.056
−20.201
1.00
23.77
B
C


ATOM
13678
OD1
ASP
B
323
30.528
0.081
−20.377
1.00
23.68
B
O


ATOM
13679
OD2
ASP
B
323
31.302
1.725
−19.143
1.00
23.10
B
O


ATOM
13680
C
ASP
B
323
33.937
0.740
−23.051
1.00
21.15
B
C


ATOM
13681
O
ASP
B
323
33.467
0.856
−24.182
1.00
20.67
B
O


ATOM
13683
N
LEU
B
324
35.214
1.001
−22.767
1.00
20.28
B
N


ATOM
13684
CA
LEU
B
324
36.155
1.517
−23.766
1.00
19.81
B
C


ATOM
13686
CB
LEU
B
324
37.278
2.299
−23.075
1.00
19.75
B
C


ATOM
13689
CG
LEU
B
324
36.855
3.536
−22.280
1.00
19.79
B
C


ATOM
13691
CD1
LEU
B
324
38.033
4.107
−21.504
1.00
18.72
B
C


ATOM
13695
CD2
LEU
B
324
36.257
4.590
−23.200
1.00
19.38
B
C


ATOM
13699
C
LEU
B
324
36.775
0.408
−24.620
1.00
19.40
B
C


ATOM
13700
O
LEU
B
324
36.895
−0.731
−24.164
1.00
19.28
B
O


ATOM
13702
N
PRO
B
325
37.186
0.743
−25.860
1.00
18.93
B
N


ATOM
13703
CA
PRO
B
325
37.864
−0.226
−26.720
1.00
18.63
B
C


ATOM
13705
CB
PRO
B
325
37.910
0.480
−28.077
1.00
18.57
B
C


ATOM
13708
CG
PRO
B
325
37.894
1.915
−27.751
1.00
18.71
B
C


ATOM
13711
CD
PRO
B
325
37.036
2.048
−26.528
1.00
18.93
B
C


ATOM
13714
C
PRO
B
325
39.274
−0.545
−26.227
1.00
18.43
B
C


ATOM
13715
O
PRO
B
325
39.858
0.231
−25.468
1.00
17.77
B
O


ATOM
13716
N
ASP
B
326
39.808
−1.676
−26.678
1.00
18.61
B
N


ATOM
13717
CA
ASP
B
326
41.035
−2.248
−26.113
1.00
18.76
B
C


ATOM
13719
CB
ASP
B
326
41.455
−3.501
−26.894
1.00
19.31
B
C


ATOM
13722
CG
ASP
B
326
40.570
−4.708
−26.599
1.00
20.22
B
C


ATOM
13723
OD1
ASP
B
326
39.894
−4.730
−25.545
1.00
21.20
B
O


ATOM
13724
OD2
ASP
B
326
40.565
−5.649
−27.422
1.00
21.66
B
O


ATOM
13725
C
ASP
B
326
42.211
−1.277
−26.015
1.00
18.24
B
C


ATOM
13726
O
ASP
B
326
42.806
−1.145
−24.948
1.00
18.18
B
O


ATOM
13728
N
TYR
B
327
42.547
−0.599
−27.109
1.00
17.94
B
N


ATOM
13729
CA
TYR
B
327
43.695
0.316
−27.094
1.00
17.68
B
C


ATOM
13731
CB
TYR
B
327
44.061
0.800
−28.506
1.00
17.63
B
C


ATOM
13734
CG
TYR
B
327
43.152
1.858
−29.101
1.00
17.30
B
C


ATOM
13735
CD1
TYR
B
327
41.980
1.506
−29.768
1.00
17.77
B
C


ATOM
13737
CE1
TYR
B
327
41.151
2.475
−30.328
1.00
17.15
B
C


ATOM
13739
CZ
TYR
B
327
41.497
3.811
−30.233
1.00
17.82
B
C


ATOM
13740
OH
TYR
B
327
40.684
4.774
−30.783
1.00
19.10
B
O


ATOM
13742
CE2
TYR
B
327
42.659
4.185
−29.584
1.00
17.85
B
C


ATOM
13744
CD2
TYR
B
327
43.482
3.208
−29.027
1.00
17.88
B
C


ATOM
13746
C
TYR
B
327
43.474
1.497
−26.149
1.00
17.55
B
C


ATOM
13747
O
TYR
B
327
44.435
2.025
−25.587
1.00
17.97
B
O


ATOM
13749
N
MET
B
328
42.215
1.894
−25.966
1.00
17.24
B
N


ATOM
13750
CA
MET
B
328
41.866
2.972
−25.033
1.00
16.88
B
C


ATOM
13752
CB
MET
B
328
40.511
3.582
−25.390
1.00
16.72
B
C


ATOM
13755
CG
MET
B
328
40.549
4.380
−26.674
1.00
16.24
B
C


ATOM
13758
SD
MET
B
328
39.002
5.199
−27.066
1.00
13.82
B
S


ATOM
13759
CE
MET
B
328
39.582
6.357
−28.303
1.00
13.73
B
C


ATOM
13763
C
MET
B
328
41.865
2.507
−23.578
1.00
16.65
B
C


ATOM
13764
O
MET
B
328
42.227
3.274
−22.688
1.00
16.22
B
O


ATOM
13766
N
LYS
B
329
41.449
1.262
−23.342
1.00
16.55
B
N


ATOM
13767
CA
LYS
B
329
41.524
0.661
−22.008
1.00
16.67
B
C


ATOM
13769
CB
LYS
B
329
41.107
−0.813
−22.045
1.00
17.17
B
C


ATOM
13772
CG
LYS
B
329
39.614
−1.076
−22.199
1.00
19.24
B
C


ATOM
13775
CD
LYS
B
329
39.370
−2.516
−22.662
1.00
21.98
B
C


ATOM
13778
CE
LYS
B
329
38.095
−3.116
−22.093
1.00
23.19
B
C


ATOM
13781
NZ
LYS
B
329
37.911
−4.532
−22.538
1.00
24.02
B
N


ATOM
13785
C
LYS
B
329
42.946
0.754
−21.469
1.00
16.07
B
C


ATOM
13786
O
LYS
B
329
43.177
1.281
−20.381
1.00
16.02
B
O


ATOM
13788
N
LEU
B
330
43.891
0.238
−22.248
1.00
15.71
B
N


ATOM
13789
CA
LEU
B
330
45.300
0.211
−21.859
1.00
15.48
B
C


ATOM
13791
CB
LEU
B
330
46.118
−0.574
−22.889
1.00
15.59
B
C


ATOM
13794
CG
LEU
B
330
47.578
−0.875
−22.540
1.00
15.37
B
C


ATOM
13796
CD1
LEU
B
330
47.655
−1.862
−21.387
1.00
15.91
B
C


ATOM
13800
CD2
LEU
B
330
48.314
−1.411
−23.758
1.00
14.02
B
C


ATOM
13804
C
LEU
B
330
45.868
1.622
−21.710
1.00
15.18
B
C


ATOM
13805
O
LEU
B
330
46.670
1.876
−20.812
1.00
15.28
B
O


ATOM
13807
N
CYS
B
331
45.453
2.529
−22.592
1.00
14.49
B
N


ATOM
13808
CA
CYS
B
331
45.875
3.929
−22.525
1.00
13.98
B
C


ATOM
13810
CB
CYS
B
331
45.494
4.665
−23.814
1.00
14.01
B
C


ATOM
13813
SG
CYS
B
331
45.852
6.448
−23.790
1.00
16.06
B
S


ATOM
13815
C
CYS
B
331
45.265
4.652
−21.321
1.00
13.11
B
C


ATOM
13816
O
CYS
B
331
45.969
5.344
−20.581
1.00
12.31
B
O


ATOM
13818
N
PHE
B
332
43.956
4.485
−21.137
1.00
12.49
B
N


ATOM
13819
CA
PHE
B
332
43.220
5.171
−20.074
1.00
12.12
B
C


ATOM
13821
CB
PHE
B
332
41.712
4.935
−20.229
1.00
11.94
B
C


ATOM
13824
CG
PHE
B
332
40.889
5.500
−19.105
1.00
11.71
B
C


ATOM
13825
CD1
PHE
B
332
40.586
6.852
−19.062
1.00
11.58
B
C


ATOM
13827
CE1
PHE
B
332
39.831
7.379
−18.023
1.00
12.01
B
C


ATOM
13829
CZ
PHE
B
332
39.369
6.550
−17.013
1.00
11.84
B
C


ATOM
13831
CE2
PHE
B
332
39.665
5.199
−17.044
1.00
12.39
B
C


ATOM
13833
CD2
PHE
B
332
40.423
4.680
−18.087
1.00
12.36
B
C


ATOM
13835
C
PHE
B
332
43.673
4.745
−18.674
1.00
12.03
B
C


ATOM
13836
O
PHE
B
332
43.919
5.593
−17.812
1.00
11.73
B
O


ATOM
13838
N
LEU
B
333
43.778
3.435
−18.455
1.00
11.78
B
N


ATOM
13839
CA
LEU
B
333
44.160
2.893
−17.144
1.00
11.25
B
C


ATOM
13841
CB
LEU
B
333
43.998
1.365
−17.122
1.00
10.70
B
C


ATOM
13844
CG
LEU
B
333
44.058
0.648
−15.767
1.00
8.41
B
C


ATOM
13846
CD1
LEU
B
333
43.018
1.170
−14.793
1.00
5.66
B
C


ATOM
13850
CD2
LEU
B
333
43.874
−0.840
−15.966
1.00
6.27
B
C


ATOM
13854
C
LEU
B
333
45.588
3.282
−16.761
1.00
11.55
B
C


ATOM
13855
O
LEU
B
333
45.898
3.420
−15.577
1.00
11.81
B
O


ATOM
13857
N
ALA
B
334
46.449
3.462
−17.762
1.00
11.79
B
N


ATOM
13858
CA
ALA
B
334
47.815
3.935
−17.539
1.00
11.84
B
C


ATOM
13860
CB
ALA
B
334
48.625
3.847
−18.825
1.00
11.68
B
C


ATOM
13864
C
ALA
B
334
47.809
5.369
−17.013
1.00
12.02
B
C


ATOM
13865
O
ALA
B
334
48.401
5.660
−15.975
1.00
11.95
B
O


ATOM
13867
N
LEU
B
335
47.135
6.258
−17.736
1.00
12.45
B
N


ATOM
13868
CA
LEU
B
335
46.991
7.648
−17.311
1.00
12.66
B
C


ATOM
13870
CB
LEU
B
335
46.194
8.447
−18.352
1.00
12.71
B
C


ATOM
13873
CG
LEU
B
335
46.041
9.954
−18.117
1.00
12.97
B
C


ATOM
13875
CD1
LEU
B
335
47.397
10.642
−18.055
1.00
13.00
B
C


ATOM
13879
CD2
LEU
B
335
45.178
10.572
−19.202
1.00
11.60
B
C


ATOM
13883
C
LEU
B
335
46.299
7.714
−15.950
1.00
12.72
B
C


ATOM
13884
O
LEU
B
335
46.785
8.372
−15.035
1.00
12.67
B
O


ATOM
13886
N
TYR
B
336
45.176
7.013
−15.826
1.00
13.04
B
N


ATOM
13887
CA
TYR
B
336
44.394
6.979
−14.584
1.00
13.37
B
C


ATOM
13889
CB
TYR
B
336
43.346
5.865
−14.661
1.00
13.50
B
C


ATOM
13892
CG
TYR
B
336
42.316
5.877
−13.556
1.00
13.69
B
C


ATOM
13893
CD1
TYR
B
336
41.167
6.654
−13.662
1.00
15.39
B
C


ATOM
13895
CE1
TYR
B
336
40.205
6.659
−12.659
1.00
15.19
B
C


ATOM
13897
CZ
TYR
B
336
40.386
5.879
−11.536
1.00
13.61
B
C


ATOM
13898
OH
TYR
B
336
39.433
5.885
−10.545
1.00
12.30
B
O


ATOM
13900
CE2
TYR
B
336
41.517
5.091
−11.410
1.00
13.99
B
C


ATOM
13902
CD2
TYR
B
336
42.472
5.091
−12.420
1.00
13.11
B
C


ATOM
13904
C
TYR
B
336
45.276
6.778
−13.351
1.00
13.42
B
C


ATOM
13905
O
TYR
B
336
45.282
7.612
−12.446
1.00
13.88
B
O


ATOM
13907
N
ASN
B
337
46.026
5.678
−13.336
1.00
13.13
B
N


ATOM
13908
CA
ASN
B
337
46.914
5.349
−12.221
1.00
12.80
B
C


ATOM
13910
CB
ASN
B
337
47.573
3.985
−12.443
1.00
12.62
B
C


ATOM
13913
CG
ASN
B
337
46.576
2.842
−12.446
1.00
12.42
B
C


ATOM
13914
OD1
ASN
B
337
45.386
3.036
−12.200
1.00
11.43
B
O


ATOM
13915
ND2
ASN
B
337
47.062
1.639
−12.726
1.00
12.41
B
N


ATOM
13918
C
ASN
B
337
47.997
6.404
−12.020
1.00
13.00
B
C


ATOM
13919
O
ASN
B
337
48.274
6.810
−10.891
1.00
13.85
B
O


ATOM
13921
N
THR
B
338
48.606
6.838
−13.120
1.00
12.67
B
N


ATOM
13922
CA
THR
B
338
49.656
7.852
−13.079
1.00
12.12
B
C


ATOM
13924
CB
THR
B
338
50.137
8.222
−14.498
1.00
11.99
B
C


ATOM
13926
OG1
THR
B
338
50.664
7.057
−15.145
1.00
9.18
B
O


ATOM
13928
CG2
THR
B
338
51.207
9.303
−14.444
1.00
11.84
B
C


ATOM
13932
C
THR
B
338
49.161
9.111
−12.384
1.00
12.48
B
C


ATOM
13933
O
THR
B
338
49.859
9.671
−11.540
1.00
12.39
B
O


ATOM
13935
N
ILE
B
339
47.950
9.540
−12.734
1.00
13.07
B
N


ATOM
13936
CA
ILE
B
339
47.373
10.759
−12.172
1.00
13.52
B
C


ATOM
13938
CB
ILE
B
339
46.123
11.241
−12.956
1.00
13.22
B
C


ATOM
13940
CG1
ILE
B
339
46.443
11.474
−14.438
1.00
12.90
B
C


ATOM
13943
CD1
ILE
B
339
47.622
12.375
−14.683
1.00
11.77
B
C


ATOM
13947
CG2
ILE
B
339
45.587
12.534
−12.362
1.00
12.97
B
C


ATOM
13951
C
ILE
B
339
47.018
10.561
−10.697
1.00
14.03
B
C


ATOM
13952
O
ILE
B
339
47.294
11.430
−9.870
1.00
15.15
B
O


ATOM
13954
N
ASN
B
340
46.419
9.422
−10.364
1.00
13.83
B
N


ATOM
13955
CA
ASN
B
340
46.116
9.116
−8.967
1.00
13.79
B
C


ATOM
13957
CB
ASN
B
340
45.287
7.837
−8.852
1.00
13.39
B
C


ATOM
13960
CG
ASN
B
340
43.876
8.015
−9.360
1.00
12.83
B
C


ATOM
13961
OD1
ASN
B
340
43.552
9.024
−9.987
1.00
11.69
B
O


ATOM
13962
ND2
ASN
B
340
43.024
7.035
−9.092
1.00
12.15
B
N


ATOM
13965
C
ASN
B
340
47.375
8.995
−8.115
1.00
14.39
B
C


ATOM
13966
O
ASN
B
340
47.356
9.331
−6.933
1.00
14.92
B
O


ATOM
13968
N
GLU
B
341
48.465
8.527
−8.720
1.00
14.80
B
N


ATOM
13969
CA
GLU
B
341
49.731
8.361
−8.006
1.00
15.19
B
C


ATOM
13971
CB
GLU
B
341
50.702
7.500
−8.819
1.00
15.65
B
C


ATOM
13974
CG
GLU
B
341
52.057
7.297
−8.150
1.00
17.64
B
C


ATOM
13977
CD
GLU
B
341
52.785
6.076
−8.668
1.00
21.06
B
C


ATOM
13978
OE1
GLU
B
341
53.791
6.243
−9.394
1.00
22.18
B
O


ATOM
13979
OE2
GLU
B
341
52.343
4.951
−8.353
1.00
23.01
B
O


ATOM
13980
C
GLU
B
341
50.376
9.704
−7.652
1.00
14.68
B
C


ATOM
13981
O
GLU
B
341
50.952
9.848
−6.573
1.00
14.72
B
O


ATOM
13983
N
ILE
B
342
50.288
10.679
−8.555
1.00
14.12
B
N


ATOM
13984
CA
ILE
B
342
50.753
12.035
−8.253
1.00
13.72
B
C


ATOM
13986
CB
ILE
B
342
50.765
12.945
−9.498
1.00
13.57
B
C


ATOM
13988
CG1
ILE
B
342
51.775
12.434
−10.526
1.00
14.64
B
C


ATOM
13991
CD1
ILE
B
342
51.843
13.277
−11.792
1.00
15.37
B
C


ATOM
13995
CG2
ILE
B
342
51.123
14.376
−9.111
1.00
13.73
B
C


ATOM
13999
C
ILE
B
342
49.858
12.654
−7.179
1.00
13.24
B
C


ATOM
14000
O
ILE
B
342
50.340
13.359
−6.290
1.00
13.44
B
O


ATOM
14002
N
ALA
B
343
48.557
12.379
−7.270
1.00
12.34
B
N


ATOM
14003
CA
ALA
B
343
47.592
12.806
−6.261
1.00
11.40
B
C


ATOM
14005
CB
ALA
B
343
46.197
12.362
−6.654
1.00
11.24
B
C


ATOM
14009
C
ALA
B
343
47.956
12.253
−4.883
1.00
10.91
B
C


ATOM
14010
O
ALA
B
343
47.833
12.953
−3.876
1.00
10.88
B
O


ATOM
14012
N
TYR
B
344
48.409
11.001
−4.851
1.00
10.38
B
N


ATOM
14013
CA
TYR
B
344
48.833
10.355
−3.607
1.00
10.04
B
C


ATOM
14015
CB
TYR
B
344
49.023
8.845
−3.814
1.00
9.93
B
C


ATOM
14018
CG
TYR
B
344
49.475
8.118
−2.569
1.00
8.21
B
C


ATOM
14019
CD1
TYR
B
344
48.553
7.639
−1.648
1.00
6.65
B
C


ATOM
14021
CE1
TYR
B
344
48.963
6.982
−0.497
1.00
6.47
B
C


ATOM
14023
CZ
TYR
B
344
50.309
6.799
−0.254
1.00
6.00
B
C


ATOM
14024
OH
TYR
B
344
50.715
6.147
0.888
1.00
4.30
B
O


ATOM
14026
CE2
TYR
B
344
51.247
7.268
−1.154
1.00
7.46
B
C


ATOM
14028
CD2
TYR
B
344
50.827
7.924
−2.304
1.00
8.03
B
C


ATOM
14030
C
TYR
B
344
50.119
10.977
−3.064
1.00
10.06
B
C


ATOM
14031
O
TYR
B
344
50.269
11.142
−1.856
1.00
10.03
B
O


ATOM
14033
N
ASP
B
345
51.047
11.310
−3.957
1.00
10.36
B
N


ATOM
14034
CA
ASP
B
345
52.284
11.982
−3.559
1.00
10.78
B
C


ATOM
14036
CB
ASP
B
345
53.256
12.088
−4.740
1.00
10.82
B
C


ATOM
14039
CG
ASP
B
345
53.868
10.755
−5.123
1.00
10.93
B
C


ATOM
14040
OD1
ASP
B
345
53.973
9.858
−4.256
1.00
11.03
B
O


ATOM
14041
OD2
ASP
B
345
54.258
10.610
−6.300
1.00
12.06
B
O


ATOM
14042
C
ASP
B
345
52.011
13.377
−2.999
1.00
11.16
B
C


ATOM
14043
O
ASP
B
345
52.830
13.919
−2.259
1.00
11.52
B
O


ATOM
14045
N
ASN
B
346
50.873
13.959
−3.366
1.00
11.44
B
N


ATOM
14046
CA
ASN
B
346
50.468
15.260
−2.843
1.00
11.76
B
C


ATOM
14048
CB
ASN
B
346
49.615
16.005
−3.872
1.00
11.96
B
C


ATOM
14051
CG
ASN
B
346
50.458
16.711
−4.910
1.00
13.27
B
C


ATOM
14052
OD1
ASN
B
346
51.086
17.729
−4.618
1.00
18.45
B
O


ATOM
14053
ND2
ASN
B
346
50.485
16.174
−6.128
1.00
12.71
B
N


ATOM
14056
C
ASN
B
346
49.733
15.140
−1.514
1.00
11.65
B
C


ATOM
14057
O
ASN
B
346
49.944
15.953
−0.612
1.00
11.65
B
O


ATOM
14059
N
LEU
B
347
48.876
14.126
−1.399
1.00
11.52
B
N


ATOM
14060
CA
LEU
B
347
48.164
13.847
−0.150
1.00
11.25
B
C


ATOM
14062
CB
LEU
B
347
47.136
12.728
−0.350
1.00
10.95
B
C


ATOM
14065
CG
LEU
B
347
46.235
12.390
0.843
1.00
9.89
B
C


ATOM
14067
CD1
LEU
B
347
45.291
13.541
1.145
1.00
9.37
B
C


ATOM
14071
CD2
LEU
B
347
45.457
11.109
0.585
1.00
8.58
B
C


ATOM
14075
C
LEU
B
347
49.123
13.460
0.973
1.00
11.48
B
C


ATOM
14076
O
LEU
B
347
48.844
13.722
2.138
1.00
11.80
B
O


ATOM
14078
N
LYS
B
348
50.245
12.833
0.628
1.00
11.67
B
N


ATOM
14079
CA
LYS
B
348
51.230
12.424
1.627
1.00
11.74
B
C


ATOM
14081
CB
LYS
B
348
52.176
11.361
1.053
1.00
11.69
B
C


ATOM
14084
CG
LYS
B
348
53.032
10.658
2.104
1.00
10.78
B
C


ATOM
14087
CD
LYS
B
348
53.948
9.598
1.497
1.00
9.66
B
C


ATOM
14090
CE
LYS
B
348
55.189
10.191
0.836
1.00
8.44
B
C


ATOM
14093
NZ
LYS
B
348
54.959
10.572
−0.583
1.00
7.87
B
N


ATOM
14097
C
LYS
B
348
52.033
13.625
2.125
1.00
11.88
B
C


ATOM
14098
O
LYS
B
348
52.147
13.851
3.330
1.00
11.65
B
O


ATOM
14100
N
ASP
B
349
52.574
14.398
1.192
1.00
12.38
B
N


ATOM
14101
CA
ASP
B
349
53.508
15.469
1.532
1.00
13.33
B
C


ATOM
14103
CB
ASP
B
349
54.425
15.775
0.342
1.00
13.19
B
C


ATOM
14106
CG
ASP
B
349
55.170
14.546
−0.155
1.00
11.88
B
C


ATOM
14107
OD1
ASP
B
349
55.312
13.572
0.616
1.00
7.56
B
O


ATOM
14108
OD2
ASP
B
349
55.610
14.556
−1.324
1.00
11.49
B
O


ATOM
14109
C
ASP
B
349
52.808
16.745
1.996
1.00
14.12
B
C


ATOM
14110
O
ASP
B
349
53.261
17.387
2.944
1.00
14.75
B
O


ATOM
14112
N
LYS
B
350
51.711
17.107
1.335
1.00
14.58
B
N


ATOM
14113
CA
LYS
B
350
51.003
18.357
1.634
1.00
15.29
B
C


ATOM
14115
CB
LYS
B
350
50.751
19.137
0.339
1.00
15.87
B
C


ATOM
14118
CG
LYS
B
350
52.035
19.487
−0.411
1.00
18.40
B
C


ATOM
14121
CD
LYS
B
350
51.775
20.337
−1.651
1.00
20.21
B
C


ATOM
14124
CE
LYS
B
350
52.936
20.246
−2.646
1.00
20.06
B
C


ATOM
14127
NZ
LYS
B
350
54.271
20.455
−2.007
1.00
19.09
B
N


ATOM
14131
C
LYS
B
350
49.691
18.156
2.407
1.00
14.89
B
C


ATOM
14132
O
LYS
B
350
49.227
19.073
3.088
1.00
14.72
B
O


ATOM
14134
N
GLY
B
351
49.098
16.970
2.304
1.00
14.61
B
N


ATOM
14135
CA
GLY
B
351
47.889
16.645
3.060
1.00
14.57
B
C


ATOM
14138
C
GLY
B
351
46.615
17.209
2.463
1.00
14.52
B
C


ATOM
14139
O
GLY
B
351
45.688
17.560
3.193
1.00
14.37
B
O


ATOM
14141
N
GLU
B
352
46.568
17.286
1.134
1.00
14.82
B
N


ATOM
14142
CA
GLU
B
352
45.429
17.859
0.416
1.00
15.23
B
C


ATOM
14144
CB
GLU
B
352
45.789
19.240
−0.144
1.00
15.22
B
C


ATOM
14147
CG
GLU
B
352
46.260
20.271
0.894
1.00
15.93
B
C


ATOM
14150
CD
GLU
B
352
45.126
21.048
1.543
1.00
16.01
B
C


ATOM
14151
OE1
GLU
B
352
43.998
20.519
1.642
1.00
17.82
B
O


ATOM
14152
OE2
GLU
B
352
45.372
22.198
1.962
1.00
15.28
B
O


ATOM
14153
C
GLU
B
352
45.033
16.946
−0.738
1.00
15.54
B
C


ATOM
14154
O
GLU
B
352
45.897
16.437
−1.456
1.00
15.74
B
O


ATOM
14156
N
ASN
B
353
43.730
16.738
−0.914
1.00
15.72
B
N


ATOM
14157
CA
ASN
B
353
43.228
15.980
−2.058
1.00
15.71
B
C


ATOM
14159
CB
ASN
B
353
41.856
15.361
−1.762
1.00
15.94
B
C


ATOM
14162
CG
ASN
B
353
41.403
14.388
−2.847
1.00
16.62
B
C


ATOM
14163
OD1
ASN
B
353
41.769
14.521
−4.016
1.00
16.74
B
O


ATOM
14164
ND2
ASN
B
353
40.602
13.403
−2.459
1.00
17.81
B
N


ATOM
14167
C
ASN
B
353
43.148
16.888
−3.277
1.00
15.38
B
C


ATOM
14168
O
ASN
B
353
42.204
17.666
−3.424
1.00
15.14
B
O


ATOM
14170
N
ILE
B
354
44.145
16.775
−4.149
1.00
15.29
B
N


ATOM
14171
CA
ILE
B
354
44.202
17.576
−5.369
1.00
15.35
B
C


ATOM
14173
CB
ILE
B
354
45.608
18.197
−5.558
1.00
15.18
B
C


ATOM
14175
CG1
ILE
B
354
46.670
17.121
−5.797
1.00
14.74
B
C


ATOM
14178
CD1
ILE
B
354
47.872
17.644
−6.528
1.00
14.74
B
C


ATOM
14182
CG2
ILE
B
354
45.982
19.020
−4.343
1.00
15.14
B
C


ATOM
14186
C
ILE
B
354
43.801
16.778
−6.623
1.00
15.64
B
C


ATOM
14187
O
ILE
B
354
44.136
17.163
−7.743
1.00
15.61
B
O


ATOM
14189
N
LEU
B
355
43.077
15.676
−6.437
1.00
15.92
B
N


ATOM
14190
CA
LEU
B
355
42.667
14.836
−7.564
1.00
15.93
B
C


ATOM
14192
CB
LEU
B
355
42.060
13.514
−7.073
1.00
15.64
B
C


ATOM
14195
CG
LEU
B
355
41.802
12.439
−8.136
1.00
14.69
B
C


ATOM
14197
CD1
LEU
B
355
43.070
12.105
−8.906
1.00
13.49
B
C


ATOM
14201
CD2
LEU
B
355
41.222
11.184
−7.499
1.00
14.54
B
C


ATOM
14205
C
LEU
B
355
41.698
15.550
−8.517
1.00
16.22
B
C


ATOM
14206
O
LEU
B
355
41.836
15.418
−9.735
1.00
16.22
B
O


ATOM
14208
N
PRO
B
356
40.724
16.311
−7.975
1.00
16.49
B
N


ATOM
14209
CA
PRO
B
356
39.781
16.987
−8.869
1.00
16.94
B
C


ATOM
14211
CB
PRO
B
356
38.843
17.727
−7.906
1.00
16.89
B
C


ATOM
14214
CG
PRO
B
356
38.992
17.035
−6.615
1.00
16.92
B
C


ATOM
14217
CD
PRO
B
356
40.410
16.581
−6.562
1.00
16.28
B
C


ATOM
14220
C
PRO
B
356
40.460
17.974
−9.817
1.00
17.52
B
C


ATOM
14221
O
PRO
B
356
40.087
18.046
−10.987
1.00
18.27
B
O


ATOM
14222
N
TYR
B
357
41.452
18.712
−9.318
1.00
17.33
B
N


ATOM
14223
CA
TYR
B
357
42.179
19.690
−10.138
1.00
17.07
B
C


ATOM
14225
CB
TYR
B
357
43.048
20.621
−9.276
1.00
16.94
B
C


ATOM
14228
CG
TYR
B
357
42.411
21.040
−7.969
1.00
17.63
B
C


ATOM
14229
CD1
TYR
B
357
41.167
21.663
−7.945
1.00
19.45
B
C


ATOM
14231
CE1
TYR
B
357
40.575
22.042
−6.742
1.00
19.39
B
C


ATOM
14233
CZ
TYR
B
357
41.234
21.798
−5.551
1.00
18.35
B
C


ATOM
14234
OH
TYR
B
357
40.661
22.171
−4.360
1.00
19.17
B
O


ATOM
14236
CE2
TYR
B
357
42.470
21.183
−5.550
1.00
17.99
B
C


ATOM
14238
CD2
TYR
B
357
43.051
20.807
−6.755
1.00
18.02
B
C


ATOM
14240
C
TYR
B
357
43.052
18.987
−11.180
1.00
16.70
B
C


ATOM
14241
O
TYR
B
357
43.176
19.463
−12.308
1.00
17.02
B
O


ATOM
14243
N
LEU
B
358
43.649
17.858
−10.797
1.00
16.01
B
N


ATOM
14244
CA
LEU
B
358
44.510
17.088
−11.699
1.00
15.44
B
C


ATOM
14246
CB
LEU
B
358
45.321
16.046
−10.922
1.00
15.39
B
C


ATOM
14249
CG
LEU
B
358
46.418
16.579
−9.998
1.00
15.39
B
C


ATOM
14251
CD1
LEU
B
358
46.969
15.455
−9.137
1.00
16.30
B
C


ATOM
14255
CD2
LEU
B
358
47.531
17.241
−10.791
1.00
15.02
B
C


ATOM
14259
C
LEU
B
358
43.720
16.397
−12.810
1.00
15.07
B
C


ATOM
14260
O
LEU
B
358
44.217
16.259
−13.928
1.00
14.92
B
O


ATOM
14262
N
THR
B
359
42.502
15.956
−12.501
1.00
14.50
B
N


ATOM
14263
CA
THR
B
359
41.643
15.320
−13.501
1.00
14.14
B
C


ATOM
14265
CB
THR
B
359
40.620
14.372
−12.857
1.00
14.08
B
C


ATOM
14267
OG1
THR
B
359
39.832
15.087
−11.896
1.00
13.76
B
O


ATOM
14269
CG2
THR
B
359
41.334
13.219
−12.179
1.00
13.80
B
C


ATOM
14273
C
THR
B
359
40.904
16.350
−14.349
1.00
13.91
B
C


ATOM
14274
O
THR
B
359
40.619
16.097
−15.519
1.00
13.91
B
O


ATOM
14276
N
LYS
B
360
40.595
17.505
−13.761
1.00
13.68
B
N


ATOM
14277
CA
LYS
B
360
39.919
18.583
−14.487
1.00
13.73
B
C


ATOM
14279
CB
LYS
B
360
39.565
19.742
−13.541
1.00
14.11
B
C


ATOM
14282
CG
LYS
B
360
38.670
20.824
−14.147
1.00
15.76
B
C


ATOM
14285
CD
LYS
B
360
37.240
20.337
−14.337
1.00
17.92
B
C


ATOM
14288
CE
LYS
B
360
36.414
21.340
−15.130
1.00
19.80
B
C


ATOM
14291
NZ
LYS
B
360
35.031
20.844
−15.397
1.00
21.13
B
N


ATOM
14295
C
LYS
B
360
40.785
19.080
−15.646
1.00
13.04
B
C


ATOM
14296
O
LYS
B
360
40.277
19.341
−16.738
1.00
12.64
B
O


ATOM
14298
N
ALA
B
361
42.089
19.200
−15.400
1.00
12.50
B
N


ATOM
14299
CA
ALA
B
361
43.043
19.582
−16.436
1.00
12.11
B
C


ATOM
14301
CB
ALA
B
361
44.430
19.730
−15.850
1.00
11.80
B
C


ATOM
14305
C
ALA
B
361
43.056
18.556
−17.562
1.00
12.30
B
C


ATOM
14306
O
ALA
B
361
43.047
18.925
−18.738
1.00
12.61
B
O


ATOM
14308
N
TRP
B
362
43.066
17.274
−17.198
1.00
12.41
B
N


ATOM
14309
CA
TRP
B
362
43.062
16.187
−18.184
1.00
12.60
B
C


ATOM
14311
CB
TRP
B
362
43.484
14.860
−17.545
1.00
12.31
B
C


ATOM
14314
CG
TRP
B
362
44.957
14.676
−17.578
1.00
12.74
B
C


ATOM
14315
CD1
TRP
B
362
45.823
14.737
−16.524
1.00
13.49
B
C


ATOM
14317
NE1
TRP
B
362
47.110
14.535
−16.958
1.00
12.06
B
N


ATOM
14319
CE2
TRP
B
362
47.093
14.347
−18.315
1.00
11.96
B
C


ATOM
14320
CD2
TRP
B
362
45.751
14.432
−18.737
1.00
11.61
B
C


ATOM
14321
CE3
TRP
B
362
45.459
14.278
−20.094
1.00
11.70
B
C


ATOM
14323
CZ3
TRP
B
362
46.499
14.042
−20.975
1.00
12.47
B
C


ATOM
14325
CH2
TRP
B
362
47.824
13.960
−20.525
1.00
12.99
B
C


ATOM
14327
CZ2
TRP
B
362
48.140
14.110
−19.201
1.00
12.91
B
C


ATOM
14329
C
TRP
B
362
41.725
16.024
−18.904
1.00
13.17
B
C


ATOM
14330
O
TRP
B
362
41.682
15.459
−19.997
1.00
13.14
B
O


ATOM
14332
N
ALA
B
363
40.646
16.510
−18.289
1.00
13.48
B
N


ATOM
14333
CA
ALA
B
363
39.325
16.500
−18.915
1.00
13.34
B
C


ATOM
14335
CB
ALA
B
363
38.235
16.626
−17.862
1.00
13.16
B
C


ATOM
14339
C
ALA
B
363
39.214
17.625
−19.940
1.00
13.54
B
C


ATOM
14340
O
ALA
B
363
38.772
17.398
−21.066
1.00
13.89
B
O


ATOM
14342
N
ASP
B
364
39.626
18.831
−19.553
1.00
13.59
B
N


ATOM
14343
CA
ASP
B
364
39.577
19.995
−20.447
1.00
13.61
B
C


ATOM
14345
CB
ASP
B
364
39.922
21.277
−19.683
1.00
13.78
B
C


ATOM
14348
CG
ASP
B
364
38.894
21.626
−18.616
1.00
16.18
B
C


ATOM
14349
OD1
ASP
B
364
38.028
20.775
−18.311
1.00
19.21
B
O


ATOM
14350
OD2
ASP
B
364
38.957
22.753
−18.077
1.00
17.35
B
O


ATOM
14351
C
ASP
B
364
40.503
19.861
−21.666
1.00
13.27
B
C


ATOM
14352
O
ASP
B
364
40.219
20.435
−22.721
1.00
12.94
B
O


ATOM
14354
N
LEU
B
365
41.601
19.116
−21.521
1.00
12.55
B
N


ATOM
14355
CA
LEU
B
365
42.537
18.901
−22.627
1.00
11.93
B
C


ATOM
14357
CB
LEU
B
365
43.893
18.407
−22.108
1.00
11.48
B
C


ATOM
14360
CG
LEU
B
365
44.991
18.096
−23.139
1.00
9.74
B
C


ATOM
14362
CD1
LEU
B
365
45.213
19.237
−24.114
1.00
7.44
B
C


ATOM
14366
CD2
LEU
B
365
46.293
17.754
−22.438
1.00
7.19
B
C


ATOM
14370
C
LEU
B
365
41.968
17.917
−23.643
1.00
12.31
B
C


ATOM
14371
O
LEU
B
365
42.123
18.103
−24.848
1.00
12.10
B
O


ATOM
14373
N
CYS
B
366
41.312
16.870
−23.156
1.00
13.31
B
N


ATOM
14374
CA
CYS
B
366
40.674
15.889
−24.034
1.00
14.41
B
C


ATOM
14376
CB
CYS
B
366
40.246
14.655
−23.240
1.00
14.50
B
C


ATOM
14379
SG
CYS
B
366
41.629
13.759
−22.500
1.00
14.66
B
S


ATOM
14381
C
CYS
B
366
39.475
16.505
−24.756
1.00
15.14
B
C


ATOM
14382
O
CYS
B
366
39.314
16.319
−25.966
1.00
15.49
B
O


ATOM
14384
N
ASN
B
367
38.641
17.229
−24.005
1.00
15.16
B
N


ATOM
14385
CA
ASN
B
367
37.579
18.057
−24.585
1.00
14.89
B
C


ATOM
14387
CB
ASN
B
367
36.875
18.893
−23.502
1.00
14.96
B
C


ATOM
14390
CG
ASN
B
367
35.727
18.155
−22.831
1.00
14.43
B
C


ATOM
14391
OD1
ASN
B
367
34.815
17.660
−23.495
1.00
13.51
B
O


ATOM
14392
ND2
ASN
B
367
35.751
18.110
−21.503
1.00
13.11
B
N


ATOM
14395
C
ASN
B
367
38.139
19.000
−25.648
1.00
15.02
B
C


ATOM
14396
O
ASN
B
367
37.520
19.203
−26.691
1.00
14.98
B
O


ATOM
14398
N
ALA
B
368
39.309
19.574
−25.368
1.00
15.27
B
N


ATOM
14399
CA
ALA
B
368
39.981
20.480
−26.303
1.00
15.42
B
C


ATOM
14401
CB
ALA
B
368
41.197
21.126
−25.646
1.00
15.49
B
C


ATOM
14405
C
ALA
B
368
40.394
19.763
−27.583
1.00
15.38
B
C


ATOM
14406
O
ALA
B
368
40.305
20.335
−28.672
1.00
14.84
B
O


ATOM
14408
N
PHE
B
369
40.850
18.517
−27.444
1.00
15.74
B
N


ATOM
14409
CA
PHE
B
369
41.198
17.689
−28.600
1.00
15.84
B
C


ATOM
14411
CB
PHE
B
369
41.926
16.405
−28.175
1.00
15.87
B
C


ATOM
14414
CG
PHE
B
369
43.362
16.608
−27.751
1.00
16.19
B
C


ATOM
14415
CD1
PHE
B
369
44.261
17.284
−28.565
1.00
17.44
B
C


ATOM
14417
CE1
PHE
B
369
45.589
17.449
−28.175
1.00
17.59
B
C


ATOM
14419
CZ
PHE
B
369
46.031
16.919
−26.978
1.00
14.90
B
C


ATOM
14421
CE2
PHE
B
369
45.152
16.230
−26.169
1.00
14.93
B
C


ATOM
14423
CD2
PHE
B
369
43.828
16.069
−26.558
1.00
16.05
B
C


ATOM
14425
C
PHE
B
369
39.953
17.313
−29.402
1.00
15.56
B
C


ATOM
14426
O
PHE
B
369
39.951
17.391
−30.628
1.00
15.57
B
O


ATOM
14428
N
LEU
B
370
38.898
16.904
−28.705
1.00
15.73
B
N


ATOM
14429
CA
LEU
B
370
37.660
16.472
−29.358
1.00
16.24
B
C


ATOM
14431
CB
LEU
B
370
36.587
16.157
−28.302
1.00
16.24
B
C


ATOM
14434
CG
LEU
B
370
35.468
15.179
−28.670
1.00
15.94
B
C


ATOM
14436
CD1
LEU
B
370
36.027
13.860
−29.180
1.00
15.36
B
C


ATOM
14440
CD2
LEU
B
370
34.569
14.943
−27.466
1.00
15.13
B
C


ATOM
14444
C
LEU
B
370
37.167
17.547
−30.328
1.00
16.58
B
C


ATOM
14445
O
LEU
B
370
36.894
17.269
−31.496
1.00
16.08
B
O


ATOM
14447
N
GLN
B
371
37.087
18.776
−29.828
1.00
17.63
B
N


ATOM
14448
CA
GLN
B
371
36.713
19.947
−30.624
1.00
18.39
B
C


ATOM
14450
CB
GLN
B
371
36.835
21.212
−29.761
1.00
18.47
B
C


ATOM
14453
CG
GLN
B
371
36.465
22.509
−30.455
1.00
18.40
B
C


ATOM
14456
CD
GLN
B
371
35.014
22.546
−30.854
1.00
19.71
B
C


ATOM
14457
OE1
GLN
B
371
34.657
22.160
−31.965
1.00
21.51
B
O


ATOM
14458
NE2
GLN
B
371
34.161
22.995
−29.942
1.00
21.78
B
N


ATOM
14461
C
GLN
B
371
37.557
20.098
−31.899
1.00
19.05
B
C


ATOM
14462
O
GLN
B
371
37.033
20.494
−32.943
1.00
19.37
B
O


ATOM
14464
N
GLU
B
372
38.857
19.803
−31.804
1.00
19.25
B
N


ATOM
14465
CA
GLU
B
372
39.748
19.811
−32.974
1.00
19.20
B
C


ATOM
14467
CB
GLU
B
372
41.226
19.689
−32.562
1.00
19.45
B
C


ATOM
14470
CG
GLU
B
372
41.877
20.997
−32.107
1.00
21.69
B
C


ATOM
14473
CD
GLU
B
372
43.356
20.840
−31.747
1.00
24.43
B
C


ATOM
14474
OE1
GLU
B
372
43.861
19.695
−31.711
1.00
25.03
B
O


ATOM
14475
OE2
GLU
B
372
44.017
21.870
−31.498
1.00
25.72
B
O


ATOM
14476
C
GLU
B
372
39.391
18.682
−33.941
1.00
18.59
B
C


ATOM
14477
O
GLU
B
372
39.372
18.883
−35.158
1.00
18.34
B
O


ATOM
14479
N
ALA
B
373
39.108
17.502
−33.391
1.00
18.19
B
N


ATOM
14480
CA
ALA
B
373
38.762
16.331
−34.195
1.00
17.99
B
C


ATOM
14482
CB
ALA
B
373
38.816
15.070
−33.345
1.00
17.85
B
C


ATOM
14486
C
ALA
B
373
37.386
16.472
−34.844
1.00
17.94
B
C


ATOM
14487
O
ALA
B
373
37.146
15.920
−35.916
1.00
18.34
B
O


ATOM
14489
N
LYS
B
374
36.486
17.205
−34.193
1.00
17.70
B
N


ATOM
14490
CA
LYS
B
374
35.146
17.438
−34.736
1.00
17.42
B
C


ATOM
14492
CB
LYS
B
374
34.195
17.945
−33.647
1.00
17.54
B
C


ATOM
14495
CG
LYS
B
374
33.700
16.869
−32.696
1.00
16.57
B
C


ATOM
14498
CD
LYS
B
374
32.755
17.459
−31.667
1.00
16.38
B
C


ATOM
14501
CE
LYS
B
374
32.149
16.392
−30.780
1.00
16.46
B
C


ATOM
14504
NZ
LYS
B
374
31.306
16.977
−29.704
1.00
15.25
B
N


ATOM
14508
C
LYS
B
374
35.174
18.425
−35.900
1.00
17.26
B
C


ATOM
14509
O
LYS
B
374
34.513
18.208
−36.915
1.00
17.43
B
O


ATOM
14511
N
TRP
B
375
35.934
19.509
−35.750
1.00
17.18
B
N


ATOM
14512
CA
TRP
B
375
36.105
20.483
−36.832
1.00
17.31
B
C


ATOM
14514
CB
TRP
B
375
36.949
21.681
−36.372
1.00
17.16
B
C


ATOM
14517
CG
TRP
B
375
36.259
22.614
−35.404
1.00
17.13
B
C


ATOM
14518
CD1
TRP
B
375
34.916
22.857
−35.304
1.00
17.41
B
C


ATOM
14520
NE1
TRP
B
375
34.674
23.782
−34.315
1.00
17.36
B
N


ATOM
14522
CE2
TRP
B
375
35.868
24.171
−33.767
1.00
17.07
B
C


ATOM
14523
CD2
TRP
B
375
36.891
23.458
−34.429
1.00
16.95
B
C


ATOM
14524
CE3
TRP
B
375
38.221
23.677
−34.049
1.00
15.71
B
C


ATOM
14526
CZ3
TRP
B
375
38.484
24.587
−33.029
1.00
15.41
B
C


ATOM
14528
CH2
TRP
B
375
37.444
25.278
−32.389
1.00
16.22
B
C


ATOM
14530
CZ2
TRP
B
375
36.133
25.084
−32.741
1.00
16.57
B
C


ATOM
14532
C
TRP
B
375
36.750
19.842
−38.066
1.00
17.41
B
C


ATOM
14533
O
TRP
B
375
36.502
20.269
−39.198
1.00
17.35
B
O


ATOM
14535
N
LEU
B
376
37.570
18.818
−37.840
1.00
17.35
B
N


ATOM
14536
CA
LEU
B
376
38.231
18.100
−38.923
1.00
17.23
B
C


ATOM
14538
CB
LEU
B
376
39.425
17.302
−38.391
1.00
17.49
B
C


ATOM
14541
CG
LEU
B
376
40.555
17.070
−39.395
1.00
18.22
B
C


ATOM
14543
CD1
LEU
B
376
41.433
18.312
−39.485
1.00
19.63
B
C


ATOM
14547
CD2
LEU
B
376
41.383
15.849
−39.012
1.00
19.32
B
C


ATOM
14551
C
LEU
B
376
37.248
17.167
−39.627
1.00
16.88
B
C


ATOM
14552
O
LEU
B
376
37.183
17.143
−40.854
1.00
17.11
B
O


ATOM
14554
N
TYR
B
377
36.486
16.402
−38.849
1.00
16.77
B
N


ATOM
14555
CA
TYR
B
377
35.499
15.476
−39.412
1.00
17.06
B
C


ATOM
14557
CB
TYR
B
377
34.930
14.547
−38.327
1.00
17.15
B
C


ATOM
14560
CG
TYR
B
377
33.854
13.587
−38.814
1.00
17.58
B
C


ATOM
14561
CD1
TYR
B
377
34.187
12.403
−39.475
1.00
17.98
B
C


ATOM
14563
CE1
TYR
B
377
33.200
11.520
−39.920
1.00
17.11
B
C


ATOM
14565
CZ
TYR
B
377
31.865
11.820
−39.701
1.00
17.79
B
C


ATOM
14566
OH
TYR
B
377
30.880
10.962
−40.133
1.00
15.15
B
O


ATOM
14568
CE2
TYR
B
377
31.511
12.987
−39.047
1.00
19.01
B
C


ATOM
14570
CD2
TYR
B
377
32.504
13.862
−38.608
1.00
18.51
B
C


ATOM
14572
C
TYR
B
377
34.365
16.223
−40.116
1.00
16.88
B
C


ATOM
14573
O
TYR
B
377
33.846
15.748
−41.126
1.00
17.51
B
O


ATOM
14575
N
ASN
B
378
33.996
17.390
−39.590
1.00
16.33
B
N


ATOM
14576
CA
ASN
B
378
32.891
18.178
−40.140
1.00
16.09
B
C


ATOM
14578
CB
ASN
B
378
32.095
18.824
−38.999
1.00
16.18
B
C


ATOM
14581
CG
ASN
B
378
31.487
17.797
−38.053
1.00
15.67
B
C


ATOM
14582
OD1
ASN
B
378
30.872
16.821
−38.486
1.00
14.58
B
O


ATOM
14583
ND2
ASN
B
378
31.651
18.021
−36.755
1.00
13.56
B
N


ATOM
14586
C
ASN
B
378
33.333
19.252
−41.141
1.00
15.94
B
C


ATOM
14587
O
ASN
B
378
32.503
20.019
−41.630
1.00
15.56
B
O


ATOM
14589
N
LYS
B
379
34.632
19.300
−41.444
1.00
16.13
B
N


ATOM
14590
CA
LYS
B
379
35.208
20.300
−42.358
1.00
16.30
B
C


ATOM
14592
CB
LYS
B
379
34.699
20.087
−43.797
1.00
16.31
B
C


ATOM
14595
CG
LYS
B
379
35.509
19.101
−44.626
1.00
17.12
B
C


ATOM
14598
CD
LYS
B
379
35.221
19.295
−46.113
1.00
18.17
B
C


ATOM
14601
CE
LYS
B
379
35.889
18.233
−46.973
1.00
20.00
B
C


ATOM
14604
NZ
LYS
B
379
35.188
16.917
−46.903
1.00
20.73
B
N


ATOM
14608
C
LYS
B
379
34.963
21.756
−41.922
1.00
16.29
B
C


ATOM
14609
O
LYS
B
379
34.987
22.669
−42.751
1.00
16.86
B
O


ATOM
14611
N
SER
B
380
34.755
21.978
−40.625
1.00
15.76
B
N


ATOM
14612
CA
SER
B
380
34.443
23.312
−40.119
1.00
15.29
B
C


ATOM
14614
CB
SER
B
380
34.179
23.266
−38.614
1.00
15.44
B
C


ATOM
14617
OG
SER
B
380
33.129
22.367
−38.305
1.00
15.59
B
O


ATOM
14619
C
SER
B
380
35.580
24.284
−40.417
1.00
14.99
B
C


ATOM
14620
O
SER
B
380
36.743
23.885
−40.479
1.00
14.56
B
O


ATOM
14622
N
THR
B
381
35.231
25.557
−40.600
1.00
14.97
B
N


ATOM
14623
CA
THR
B
381
36.196
26.607
−40.939
1.00
14.59
B
C


ATOM
14625
CB
THR
B
381
35.976
27.102
−42.383
1.00
14.34
B
C


ATOM
14627
OG1
THR
B
381
34.623
27.544
−42.533
1.00
13.29
B
O


ATOM
14629
CG2
THR
B
381
36.243
25.984
−43.376
1.00
14.48
B
C


ATOM
14633
C
THR
B
381
36.079
27.788
−39.969
1.00
14.43
B
C


ATOM
14634
O
THR
B
381
35.732
28.900
−40.379
1.00
14.36
B
O


ATOM
14636
N
PRO
B
382
36.379
27.551
−38.676
1.00
14.16
B
N


ATOM
14637
CA
PRO
B
382
36.183
28.563
−37.635
1.00
14.13
B
C


ATOM
14639
CB
PRO
B
382
36.455
27.790
−36.336
1.00
14.03
B
C


ATOM
14642
CG
PRO
B
382
37.313
26.672
−36.731
1.00
13.70
B
C


ATOM
14645
CD
PRO
B
382
36.876
26.285
−38.107
1.00
13.99
B
C


ATOM
14648
C
PRO
B
382
37.114
29.768
−37.731
1.00
13.68
B
C


ATOM
14649
O
PRO
B
382
38.166
29.702
−38.368
1.00
13.57
B
O


ATOM
14650
N
THR
B
383
36.709
30.857
−37.082
1.00
13.56
B
N


ATOM
14651
CA
THR
B
383
37.507
32.075
−37.022
1.00
13.70
B
C


ATOM
14653
CB
THR
B
383
36.758
33.208
−36.285
1.00
13.82
B
C


ATOM
14655
OG1
THR
B
383
36.295
32.735
−35.013
1.00
13.66
B
O


ATOM
14657
CG2
THR
B
383
35.571
33.691
−37.103
1.00
13.85
B
C


ATOM
14661
C
THR
B
383
38.809
31.809
−36.289
1.00
13.73
B
C


ATOM
14662
O
THR
B
383
38.962
30.774
−35.645
1.00
14.13
B
O


ATOM
14664
N
PHE
B
384
39.744
32.747
−36.387
1.00
13.93
B
N


ATOM
14665
CA
PHE
B
384
41.013
32.645
−35.668
1.00
13.87
B
C


ATOM
14667
CB
PHE
B
384
41.974
33.752
−36.117
1.00
13.82
B
C


ATOM
14670
CG
PHE
B
384
43.181
33.906
−35.237
1.00
14.42
B
C


ATOM
14671
CD1
PHE
B
384
44.302
33.112
−35.428
1.00
15.39
B
C


ATOM
14673
CE1
PHE
B
384
45.421
33.253
−34.613
1.00
15.72
B
C


ATOM
14675
CZ
PHE
B
384
45.423
34.201
−33.597
1.00
16.47
B
C


ATOM
14677
CE2
PHE
B
384
44.307
35.002
−33.398
1.00
15.83
B
C


ATOM
14679
CD2
PHE
B
384
43.195
34.851
−34.215
1.00
15.61
B
C


ATOM
14681
C
PHE
B
384
40.803
32.697
−34.155
1.00
13.83
B
C


ATOM
14682
O
PHE
B
384
41.562
32.086
−33.407
1.00
13.69
B
O


ATOM
14684
N
ASP
B
385
39.773
33.419
−33.714
1.00
14.28
B
N


ATOM
14685
CA
ASP
B
385
39.461
33.546
−32.286
1.00
14.69
B
C


ATOM
14687
CB
ASP
B
385
38.335
34.564
−32.067
1.00
14.68
B
C


ATOM
14690
CG
ASP
B
385
38.758
35.989
−32.377
1.00
14.29
B
C


ATOM
14691
OD1
ASP
B
385
39.916
36.198
−32.801
1.00
12.29
B
O


ATOM
14692
OD2
ASP
B
385
37.922
36.901
−32.194
1.00
13.65
B
O


ATOM
14693
C
ASP
B
385
39.072
32.212
−31.647
1.00
14.95
B
C


ATOM
14694
O
ASP
B
385
39.558
31.872
−30.565
1.00
15.03
B
O


ATOM
14696
N
ASP
B
386
38.199
31.463
−32.315
1.00
15.10
B
N


ATOM
14697
CA
ASP
B
386
37.756
30.164
−31.807
1.00
15.21
B
C


ATOM
14699
CB
ASP
B
386
36.562
29.635
−32.608
1.00
14.89
B
C


ATOM
14702
CG
ASP
B
386
35.352
30.537
−32.518
1.00
13.79
B
C


ATOM
14703
OD1
ASP
B
386
35.359
31.469
−31.688
1.00
11.65
B
O


ATOM
14704
OD2
ASP
B
386
34.395
30.312
−33.284
1.00
13.99
B
O


ATOM
14705
C
ASP
B
386
38.881
29.141
−31.845
1.00
15.56
B
C


ATOM
14706
O
ASP
B
386
39.175
28.506
−30.831
1.00
15.59
B
O


ATOM
14708
N
TYR
B
387
39.509
28.987
−33.010
1.00
16.18
B
N


ATOM
14709
CA
TYR
B
387
40.535
27.961
−33.190
1.00
17.16
B
C


ATOM
14711
CB
TYR
B
387
41.021
27.871
−34.639
1.00
17.34
B
C


ATOM
14714
CG
TYR
B
387
42.013
26.745
−34.840
1.00
19.17
B
C


ATOM
14715
CD1
TYR
B
387
41.602
25.419
−34.781
1.00
22.10
B
C


ATOM
14717
CE1
TYR
B
387
42.503
24.374
−34.945
1.00
25.04
B
C


ATOM
14719
CZ
TYR
B
387
43.839
24.650
−35.170
1.00
26.53
B
C


ATOM
14720
OH
TYR
B
387
44.731
23.609
−35.338
1.00
27.53
B
O


ATOM
14722
CE2
TYR
B
387
44.278
25.965
−35.225
1.00
25.30
B
C


ATOM
14724
CD2
TYR
B
387
43.363
27.004
−35.055
1.00
22.56
B
C


ATOM
14726
C
TYR
B
387
41.729
28.180
−32.272
1.00
17.41
B
C


ATOM
14727
O
TYR
B
387
42.241
27.224
−31.689
1.00
18.04
B
O


ATOM
14729
N
PHE
B
388
42.177
29.426
−32.147
1.00
17.25
B
N


ATOM
14730
CA
PHE
B
388
43.255
29.726
−31.218
1.00
17.19
B
C


ATOM
14732
CB
PHE
B
388
43.803
31.135
−31.406
1.00
16.75
B
C


ATOM
14735
CG
PHE
B
388
45.047
31.387
−30.617
1.00
16.33
B
C


ATOM
14736
CD1
PHE
B
388
46.244
30.796
−30.994
1.00
16.78
B
C


ATOM
14738
CE1
PHE
B
388
47.401
31.006
−30.265
1.00
16.25
B
C


ATOM
14740
CZ
PHE
B
388
47.369
31.808
−29.137
1.00
16.41
B
C


ATOM
14742
CE2
PHE
B
388
46.175
32.396
−28.742
1.00
16.15
B
C


ATOM
14744
CD2
PHE
B
388
45.021
32.179
−29.479
1.00
16.35
B
C


ATOM
14746
C
PHE
B
388
42.778
29.539
−29.783
1.00
17.91
B
C


ATOM
14747
O
PHE
B
388
43.468
28.913
−28.979
1.00
18.31
B
O


ATOM
14749
N
GLY
B
389
41.590
30.062
−29.475
1.00
18.30
B
N


ATOM
14750
CA
GLY
B
389
40.982
29.902
−28.151
1.00
18.22
B
C


ATOM
14753
C
GLY
B
389
41.074
28.480
−27.625
1.00
18.15
B
C


ATOM
14754
O
GLY
B
389
41.426
28.262
−26.465
1.00
18.35
B
O


ATOM
14756
N
ASN
B
390
40.760
27.516
−28.487
1.00
17.78
B
N


ATOM
14757
CA
ASN
B
390
40.865
26.097
−28.154
1.00
17.52
B
C


ATOM
14759
CB
ASN
B
390
39.912
25.286
−29.037
1.00
17.50
B
C


ATOM
14762
CG
ASN
B
390
39.703
23.875
−28.529
1.00
17.13
B
C


ATOM
14763
OD1
ASN
B
390
39.294
23.673
−27.386
1.00
16.19
B
O


ATOM
14764
ND2
ASN
B
390
39.977
22.890
−29.377
1.00
16.14
B
N


ATOM
14767
C
ASN
B
390
42.289
25.559
−28.324
1.00
17.35
B
C


ATOM
14768
O
ASN
B
390
42.689
24.616
−27.637
1.00
16.87
B
O


ATOM
14770
N
ALA
B
391
43.041
26.160
−29.246
1.00
17.15
B
N


ATOM
14771
CA
ALA
B
391
44.367
25.670
−29.628
1.00
16.79
B
C


ATOM
14773
CB
ALA
B
391
44.874
26.414
−30.850
1.00
16.54
B
C


ATOM
14777
C
ALA
B
391
45.402
25.737
−28.507
1.00
16.67
B
C


ATOM
14778
O
ALA
B
391
46.229
24.834
−28.386
1.00
17.01
B
O


ATOM
14780
N
TRP
B
392
45.378
26.795
−27.700
1.00
16.56
B
N


ATOM
14781
CA
TRP
B
392
46.324
26.891
−26.585
1.00
16.79
B
C


ATOM
14783
CB
TRP
B
392
46.551
28.339
−26.114
1.00
16.90
B
C


ATOM
14786
CG
TRP
B
392
45.347
29.101
−25.644
1.00
16.82
B
C


ATOM
14787
CD1
TRP
B
392
44.616
29.993
−26.368
1.00
17.86
B
C


ATOM
14789
NE1
TRP
B
392
43.604
30.516
−25.601
1.00
19.26
B
N


ATOM
14791
CE2
TRP
B
392
43.675
29.974
−24.346
1.00
19.44
B
C


ATOM
14792
CD2
TRP
B
392
44.770
29.082
−24.333
1.00
18.34
B
C


ATOM
14793
CE3
TRP
B
392
45.061
28.389
−23.152
1.00
20.35
B
C


ATOM
14795
CZ3
TRP
B
392
44.259
28.606
−22.035
1.00
20.88
B
C


ATOM
14797
CH2
TRP
B
392
43.177
29.500
−22.082
1.00
20.79
B
C


ATOM
14799
CZ2
TRP
B
392
42.870
30.192
−23.224
1.00
20.30
B
C


ATOM
14801
C
TRP
B
392
45.952
25.973
−25.420
1.00
17.05
B
C


ATOM
14802
O
TRP
B
392
46.818
25.598
−24.635
1.00
17.62
B
O


ATOM
14804
N
LYS
B
393
44.682
25.596
−25.310
1.00
17.13
B
N


ATOM
14805
CA
LYS
B
393
44.297
24.524
−24.390
1.00
17.62
B
C


ATOM
14807
CB
LYS
B
393
42.771
24.422
−24.242
1.00
18.17
B
C


ATOM
14810
CG
LYS
B
393
42.149
25.470
−23.336
1.00
19.49
B
C


ATOM
14813
CD
LYS
B
393
40.637
25.300
−23.251
1.00
20.92
B
C


ATOM
14816
CE
LYS
B
393
39.987
26.436
−22.472
1.00
22.85
B
C


ATOM
14819
NZ
LYS
B
393
40.242
27.775
−23.089
1.00
23.75
B
N


ATOM
14823
C
LYS
B
393
44.855
23.190
−24.891
1.00
17.26
B
C


ATOM
14824
O
LYS
B
393
45.466
22.438
−24.130
1.00
17.57
B
O


ATOM
14826
N
SER
B
394
44.655
22.917
−26.181
1.00
16.47
B
N


ATOM
14827
CA
SER
B
394
45.061
21.644
−26.782
1.00
15.87
B
C


ATOM
14829
CB
SER
B
394
44.438
21.474
−28.173
1.00
16.34
B
C


ATOM
14832
OG
SER
B
394
45.053
22.324
−29.128
1.00
17.96
B
O


ATOM
14834
C
SER
B
394
46.573
21.488
−26.882
1.00
14.74
B
C


ATOM
14835
O
SER
B
394
47.064
20.395
−27.163
1.00
14.87
B
O


ATOM
14837
N
SER
B
395
47.306
22.581
−26.674
1.00
13.73
B
N


ATOM
14838
CA
SER
B
395
48.768
22.536
−26.627
1.00
12.86
B
C


ATOM
14840
CB
SER
B
395
49.347
23.953
−26.514
1.00
12.97
B
C


ATOM
14843
OG
SER
B
395
49.165
24.500
−25.216
1.00
10.58
B
O


ATOM
14845
C
SER
B
395
49.263
21.677
−25.460
1.00
12.10
B
C


ATOM
14846
O
SER
B
395
50.306
21.037
−25.563
1.00
12.00
B
O


ATOM
14848
N
SER
B
396
48.478
21.661
−24.379
1.00
11.22
B
N


ATOM
14849
CA
SER
B
396
48.812
21.023
−23.096
1.00
10.50
B
C


ATOM
14851
CB
SER
B
396
49.589
19.704
−23.259
1.00
10.20
B
C


ATOM
14854
OG
SER
B
396
50.988
19.921
−23.297
1.00
8.38
B
O


ATOM
14856
C
SER
B
396
49.576
21.997
−22.197
1.00
10.26
B
C


ATOM
14857
O
SER
B
396
50.076
21.611
−21.138
1.00
9.66
B
O


ATOM
14859
N
GLY
B
397
49.637
23.260
−22.623
1.00
9.98
B
N


ATOM
14860
CA
GLY
B
397
50.327
24.315
−21.889
1.00
9.92
B
C


ATOM
14863
C
GLY
B
397
49.710
24.631
−20.538
1.00
9.97
B
C


ATOM
14864
O
GLY
B
397
50.433
24.872
−19.576
1.00
10.10
B
O


ATOM
14866
N
PRO
B
398
48.368
24.665
−20.462
1.00
10.22
B
N


ATOM
14867
CA
PRO
B
398
47.702
24.796
−19.167
1.00
10.28
B
C


ATOM
14869
CB
PRO
B
398
46.239
25.041
−19.547
1.00
10.17
B
C


ATOM
14872
CG
PRO
B
398
46.294
25.597
−20.918
1.00
10.28
B
C


ATOM
14875
CD
PRO
B
398
47.428
24.886
−21.573
1.00
10.52
B
C


ATOM
14878
C
PRO
B
398
47.834
23.548
−18.292
1.00
10.37
B
C


ATOM
14879
O
PRO
B
398
48.153
23.664
−17.105
1.00
9.87
B
O


ATOM
14880
N
LEU
B
399
47.594
22.372
−18.872
1.00
10.74
B
N


ATOM
14881
CA
LEU
B
399
47.682
21.120
−18.118
1.00
10.74
B
C


ATOM
14883
CB
LEU
B
399
47.255
19.920
−18.965
1.00
10.40
B
C


ATOM
14886
CG
LEU
B
399
47.118
18.589
−18.212
1.00
8.78
B
C


ATOM
14888
CD1
LEU
B
399
46.277
17.619
−19.010
1.00
9.68
B
C


ATOM
14892
CD2
LEU
B
399
48.466
17.965
−17.903
1.00
8.42
B
C


ATOM
14896
C
LEU
B
399
49.093
20.911
−17.587
1.00
11.26
B
C


ATOM
14897
O
LEU
B
399
49.267
20.586
−16.411
1.00
12.26
B
O


ATOM
14899
N
GLN
B
400
50.095
21.095
−18.443
1.00
10.88
B
N


ATOM
14900
CA
GLN
B
400
51.482
20.980
−18.000
1.00
10.85
B
C


ATOM
14902
CB
GLN
B
400
52.459
21.371
−19.109
1.00
10.68
B
C


ATOM
14905
CG
GLN
B
400
52.718
20.268
−20.118
1.00
10.94
B
C


ATOM
14908
CD
GLN
B
400
53.840
20.605
−21.075
1.00
10.14
B
C


ATOM
14909
OE1
GLN
B
400
54.874
21.143
−20.674
1.00
8.70
B
O


ATOM
14910
NE2
GLN
B
400
53.650
20.279
−22.347
1.00
10.31
B
N


ATOM
14913
C
GLN
B
400
51.726
21.844
−16.768
1.00
11.14
B
C


ATOM
14914
O
GLN
B
400
52.241
21.358
−15.761
1.00
11.47
B
O


ATOM
14916
N
LEU
B
401
51.329
23.114
−16.845
1.00
11.14
B
N


ATOM
14917
CA
LEU
B
401
51.568
24.065
−15.759
1.00
11.06
B
C


ATOM
14919
CB
LEU
B
401
51.299
25.498
−16.221
1.00
10.61
B
C


ATOM
14922
CG
LEU
B
401
52.308
26.063
−17.224
1.00
11.73
B
C


ATOM
14924
CD1
LEU
B
401
52.040
27.539
−17.482
1.00
12.66
B
C


ATOM
14928
CD2
LEU
B
401
53.736
25.867
−16.738
1.00
15.02
B
C


ATOM
14932
C
LEU
B
401
50.761
23.747
−14.499
1.00
11.70
B
C


ATOM
14933
O
LEU
B
401
51.333
23.653
−13.412
1.00
12.09
B
O


ATOM
14935
N
VAL
B
402
49.448
23.559
−14.633
1.00
12.08
B
N


ATOM
14936
CA
VAL
B
402
48.625
23.148
−13.485
1.00
12.19
B
C


ATOM
14938
CB
VAL
B
402
47.230
22.621
−13.907
1.00
12.09
B
C


ATOM
14940
CG1
VAL
B
402
46.393
23.736
−14.500
1.00
11.45
B
C


ATOM
14944
CG2
VAL
B
402
46.508
21.992
−12.715
1.00
10.48
B
C


ATOM
14948
C
VAL
B
402
49.343
22.055
−12.691
1.00
12.73
B
C


ATOM
14949
O
VAL
B
402
49.364
22.090
−11.463
1.00
13.03
B
O


ATOM
14951
N
PHE
B
403
49.931
21.096
−13.406
1.00
12.77
B
N


ATOM
14952
CA
PHE
B
403
50.689
20.009
−12.789
1.00
12.83
B
C


ATOM
14954
CB
PHE
B
403
51.004
18.918
−13.818
1.00
13.10
B
C


ATOM
14957
CG
PHE
B
403
50.038
17.776
−13.798
1.00
13.23
B
C


ATOM
14958
CD1
PHE
B
403
50.267
16.676
−12.985
1.00
12.90
B
C


ATOM
14960
CE1
PHE
B
403
49.379
15.618
−12.959
1.00
14.26
B
C


ATOM
14962
CZ
PHE
B
403
48.241
15.653
−13.749
1.00
15.62
B
C


ATOM
14964
CE2
PHE
B
403
48.004
16.745
−14.567
1.00
15.30
B
C


ATOM
14966
CD2
PHE
B
403
48.899
17.800
−14.586
1.00
14.00
B
C


ATOM
14968
C
PHE
B
403
51.985
20.487
−12.142
1.00
12.73
B
C


ATOM
14969
O
PHE
B
403
52.337
20.036
−11.051
1.00
12.37
B
O


ATOM
14971
N
ALA
B
404
52.695
21.383
−12.824
1.00
12.86
B
N


ATOM
14972
CA
ALA
B
404
53.958
21.925
−12.317
1.00
12.97
B
C


ATOM
14974
CB
ALA
B
404
54.659
22.744
−13.395
1.00
12.54
B
C


ATOM
14978
C
ALA
B
404
53.750
22.771
−11.062
1.00
13.43
B
C


ATOM
14979
O
ALA
B
404
54.665
22.906
−10.247
1.00
13.75
B
O


ATOM
14981
N
TYR
B
405
52.549
23.332
−10.915
1.00
13.71
B
N


ATOM
14982
CA
TYR
B
405
52.200
24.148
−9.750
1.00
13.86
B
C


ATOM
14984
CB
TYR
B
405
50.762
24.667
−9.872
1.00
13.79
B
C


ATOM
14987
CG
TYR
B
405
50.254
25.335
−8.618
1.00
13.21
B
C


ATOM
14988
CD1
TYR
B
405
50.594
26.652
−8.323
1.00
12.79
B
C


ATOM
14990
CE1
TYR
B
405
50.136
27.270
−7.170
1.00
11.81
B
C


ATOM
14992
CZ
TYR
B
405
49.332
26.565
−6.298
1.00
12.37
B
C


ATOM
14993
OH
TYR
B
405
48.878
27.167
−5.154
1.00
12.04
B
O


ATOM
14995
CE2
TYR
B
405
48.983
25.251
−6.566
1.00
12.72
B
C


ATOM
14997
CD2
TYR
B
405
49.444
24.645
−7.720
1.00
12.42
B
C


ATOM
14999
C
TYR
B
405
52.357
23.371
−8.446
1.00
14.17
B
C


ATOM
15000
O
TYR
B
405
53.016
23.836
−7.515
1.00
14.28
B
O


ATOM
15002
N
PHE
B
406
51.753
22.186
−8.391
1.00
14.49
B
N


ATOM
15003
CA
PHE
B
406
51.802
21.342
−7.193
1.00
14.68
B
C


ATOM
15005
CB
PHE
B
406
50.791
20.197
−7.298
1.00
14.37
B
C


ATOM
15008
CG
PHE
B
406
49.360
20.654
−7.391
1.00
13.87
B
C


ATOM
15009
CD1
PHE
B
406
48.612
20.883
−6.246
1.00
13.63
B
C


ATOM
15011
CE1
PHE
B
406
47.290
21.297
−6.334
1.00
12.80
B
C


ATOM
15013
CZ
PHE
B
406
46.705
21.484
−7.573
1.00
11.76
B
C


ATOM
15015
CE2
PHE
B
406
47.440
21.257
−8.720
1.00
12.46
B
C


ATOM
15017
CD2
PHE
B
406
48.758
20.843
−8.626
1.00
13.06
B
C


ATOM
15019
C
PHE
B
406
53.202
20.774
−6.955
1.00
15.00
B
C


ATOM
15020
O
PHE
B
406
53.542
20.387
−5.837
1.00
14.79
B
O


ATOM
15022
N
ALA
B
407
54.001
20.725
−8.015
1.00
15.76
B
N


ATOM
15023
CA
ALA
B
407
55.372
20.243
−7.940
1.00
16.63
B
C


ATOM
15025
CB
ALA
B
407
55.849
19.847
−9.323
1.00
16.82
B
C


ATOM
15029
C
ALA
B
407
56.327
21.270
−7.338
1.00
17.61
B
C


ATOM
15030
O
ALA
B
407
57.348
20.889
−6.761
1.00
17.54
B
O


ATOM
15032
N
VAL
B
408
56.005
22.558
−7.485
1.00
18.76
B
N


ATOM
15033
CA
VAL
B
408
56.896
23.644
−7.041
1.00
19.68
B
C


ATOM
15035
CB
VAL
B
408
57.122
24.709
−8.151
1.00
19.56
B
C


ATOM
15037
CG1
VAL
B
408
57.867
24.099
−9.326
1.00
20.05
B
C


ATOM
15041
CG2
VAL
B
408
55.809
25.326
−8.608
1.00
19.46
B
C


ATOM
15045
C
VAL
B
408
56.422
24.343
−5.765
1.00
20.58
B
C


ATOM
15046
O
VAL
B
408
57.217
24.560
−4.850
1.00
20.87
B
O


ATOM
15048
N
VAL
B
409
55.137
24.686
−5.700
1.00
21.60
B
N


ATOM
15049
CA
VAL
B
409
54.589
25.416
−4.556
1.00
22.34
B
C


ATOM
15051
CB
VAL
B
409
53.202
26.016
−4.877
1.00
22.39
B
C


ATOM
15053
CG1
VAL
B
409
52.600
26.674
−3.640
1.00
23.44
B
C


ATOM
15057
CG2
VAL
B
409
53.306
27.019
−6.015
1.00
22.32
B
C


ATOM
15061
C
VAL
B
409
54.464
24.492
−3.346
1.00
22.94
B
C


ATOM
15062
O
VAL
B
409
53.760
23.483
−3.411
1.00
23.20
B
O


ATOM
15064
N
GLN
B
410
55.146
24.841
−2.254
1.00
23.53
B
N


ATOM
15065
CA
GLN
B
410
55.110
24.046
−1.021
1.00
24.19
B
C


ATOM
15067
CB
GLN
B
410
56.199
24.501
−0.038
1.00
24.35
B
C


ATOM
15070
CG
GLN
B
410
57.580
23.913
−0.322
1.00
25.13
B
C


ATOM
15073
CD
GLN
B
410
58.700
24.597
0.458
1.00
26.32
B
C


ATOM
15074
OE1
GLN
B
410
58.471
25.217
1.500
1.00
26.11
B
O


ATOM
15075
NE2
GLN
B
410
59.923
24.479
−0.047
1.00
26.55
B
N


ATOM
15078
C
GLN
B
410
53.736
24.119
−0.354
1.00
24.67
B
C


ATOM
15079
O
GLN
B
410
53.107
23.087
−0.098
1.00
24.94
B
O


ATOM
15081
N
ASN
B
411
53.282
25.340
−0.077
1.00
24.76
B
N


ATOM
15082
CA
ASN
B
411
51.964
25.568
0.515
1.00
24.87
B
C


ATOM
15084
CB
ASN
B
411
52.044
26.607
1.639
1.00
24.93
B
C


ATOM
15087
CG
ASN
B
411
52.557
26.022
2.944
1.00
25.27
B
C


ATOM
15088
OD1
ASN
B
411
52.140
26.439
4.027
1.00
25.02
B
O


ATOM
15089
ND2
ASN
B
411
53.458
25.050
2.850
1.00
24.79
B
N


ATOM
15092
C
ASN
B
411
50.967
26.024
−0.543
1.00
24.92
B
C


ATOM
15093
O
ASN
B
411
50.950
27.198
−0.924
1.00
25.20
B
O


ATOM
15095
N
ILE
B
412
50.145
25.091
−1.017
1.00
24.78
B
N


ATOM
15096
CA
ILE
B
412
49.102
25.407
−1.996
1.00
24.69
B
C


ATOM
15098
CB
ILE
B
412
48.471
24.130
−2.625
1.00
24.72
B
C


ATOM
15100
CG1
ILE
B
412
47.696
23.311
−1.585
1.00
24.16
B
C


ATOM
15103
CD1
ILE
B
412
47.342
21.919
−2.059
1.00
23.73
B
C


ATOM
15107
CG2
ILE
B
412
49.546
23.272
−3.289
1.00
25.19
B
C


ATOM
15111
C
ILE
B
412
48.015
26.260
−1.350
1.00
24.62
B
C


ATOM
15112
O
ILE
B
412
47.701
26.086
−0.176
1.00
24.66
B
O


ATOM
15114
N
LYS
B
413
47.457
27.187
−2.121
1.00
24.99
B
N


ATOM
15115
CA
LYS
B
413
46.396
28.065
−1.635
1.00
25.75
B
C


ATOM
15117
CB
LYS
B
413
46.871
29.520
−1.653
1.00
25.95
B
C


ATOM
15120
CG
LYS
B
413
48.243
29.716
−1.015
1.00
28.01
B
C


ATOM
15123
CD
LYS
B
413
48.538
31.179
−0.705
1.00
30.48
B
C


ATOM
15126
CE
LYS
B
413
49.825
31.320
0.103
1.00
31.81
B
C


ATOM
15129
NZ
LYS
B
413
50.059
32.715
0.570
1.00
32.42
B
N


ATOM
15133
C
LYS
B
413
45.152
27.892
−2.505
1.00
25.95
B
C


ATOM
15134
O
LYS
B
413
45.254
27.868
−3.735
1.00
26.19
B
O


ATOM
15136
N
LYS
B
414
43.983
27.762
−1.874
1.00
25.87
B
N


ATOM
15137
CA
LYS
B
414
42.731
27.596
−2.619
1.00
25.83
B
C


ATOM
15139
CB
LYS
B
414
41.512
27.515
−1.691
1.00
26.36
B
C


ATOM
15142
CG
LYS
B
414
40.168
27.499
−2.450
1.00
27.62
B
C


ATOM
15145
CD
LYS
B
414
38.978
27.133
−1.562
1.00
28.07
B
C


ATOM
15148
CE
LYS
B
414
38.690
28.200
−0.508
1.00
28.15
B
C


ATOM
15151
NZ
LYS
B
414
38.573
29.575
−1.081
1.00
27.51
B
N


ATOM
15155
C
LYS
B
414
42.547
28.730
−3.622
1.00
25.45
B
C


ATOM
15156
O
LYS
B
414
42.039
28.512
−4.721
1.00
25.62
B
O


ATOM
15158
N
GLU
B
415
42.958
29.936
−3.235
1.00
24.98
B
N


ATOM
15159
CA
GLU
B
415
42.926
31.092
−4.133
1.00
24.62
B
C


ATOM
15161
CB
GLU
B
415
43.333
32.377
−3.388
1.00
24.74
B
C


ATOM
15164
CG
GLU
B
415
44.180
33.364
−4.212
1.00
25.93
B
C


ATOM
15167
CD
GLU
B
415
43.994
34.813
−3.804
1.00
26.17
B
C


ATOM
15168
OE1
GLU
B
415
43.609
35.076
−2.646
1.00
28.18
B
O


ATOM
15169
OE2
GLU
B
415
44.241
35.695
−4.655
1.00
26.04
B
O


ATOM
15170
C
GLU
B
415
43.788
30.877
−5.386
1.00
23.90
B
C


ATOM
15171
O
GLU
B
415
43.367
31.210
−6.495
1.00
23.91
B
O


ATOM
15173
N
GLU
B
416
44.986
30.326
−5.209
1.00
23.17
B
N


ATOM
15174
CA
GLU
B
416
45.878
30.058
−6.338
1.00
22.78
B
C


ATOM
15176
CB
GLU
B
416
47.261
29.608
−5.855
1.00
23.14
B
C


ATOM
15179
CG
GLU
B
416
48.181
30.755
−5.454
1.00
23.54
B
C


ATOM
15182
CD
GLU
B
416
49.543
30.288
−4.962
1.00
24.77
B
C


ATOM
15183
OE1
GLU
B
416
49.646
29.171
−4.411
1.00
24.46
B
O


ATOM
15184
OE2
GLU
B
416
50.518
31.050
−5.120
1.00
26.91
B
O


ATOM
15185
C
GLU
B
416
45.285
29.017
−7.284
1.00
22.07
B
C


ATOM
15186
O
GLU
B
416
45.196
29.253
−8.490
1.00
21.50
B
O


ATOM
15188
N
ILE
B
417
44.874
27.875
−6.737
1.00
21.72
B
N


ATOM
15189
CA
ILE
B
417
44.253
26.822
−7.551
1.00
22.01
B
C


ATOM
15191
CB
ILE
B
417
44.108
25.472
−6.790
1.00
22.11
B
C


ATOM
15193
CG1
ILE
B
417
43.194
25.610
−5.576
1.00
22.41
B
C


ATOM
15196
CD1
ILE
B
417
43.202
24.395
−4.674
1.00
23.93
B
C


ATOM
15200
CG2
ILE
B
417
45.473
24.951
−6.362
1.00
22.61
B
C


ATOM
15204
C
ILE
B
417
42.898
27.249
−8.132
1.00
22.01
B
C


ATOM
15205
O
ILE
B
417
42.449
26.680
−9.127
1.00
21.57
B
O


ATOM
15207
N
GLU
B
418
42.256
28.241
−7.512
1.00
22.40
B
N


ATOM
15208
CA
GLU
B
418
41.029
28.841
−8.064
1.00
22.66
B
C


ATOM
15210
CB
GLU
B
418
40.379
29.814
−7.068
1.00
22.95
B
C


ATOM
15213
CG
GLU
B
418
39.241
29.216
−6.250
1.00
24.26
B
C


ATOM
15216
CD
GLU
B
418
38.507
30.261
−5.428
1.00
26.39
B
C


ATOM
15217
OE1
GLU
B
418
39.152
31.244
−5.003
1.00
26.91
B
O


ATOM
15218
OE2
GLU
B
418
37.287
30.099
−5.207
1.00
27.64
B
O


ATOM
15219
C
GLU
B
418
41.288
29.568
−9.384
1.00
22.19
B
C


ATOM
15220
O
GLU
B
418
40.467
29.507
−10.302
1.00
22.03
B
O


ATOM
15222
N
ASN
B
419
42.419
30.263
−9.468
1.00
21.74
B
N


ATOM
15223
CA
ASN
B
419
42.819
30.931
−10.704
1.00
21.85
B
C


ATOM
15225
CB
ASN
B
419
43.803
32.069
−10.409
1.00
21.97
B
C


ATOM
15228
CG
ASN
B
419
43.112
33.305
−9.840
1.00
22.96
B
C


ATOM
15229
OD1
ASN
B
419
42.276
33.922
−10.503
1.00
24.59
B
O


ATOM
15230
ND2
ASN
B
419
43.462
33.670
−8.609
1.00
22.29
B
N


ATOM
15233
C
ASN
B
419
43.392
29.954
−11.739
1.00
21.82
B
C


ATOM
15234
O
ASN
B
419
43.309
30.208
−12.942
1.00
21.68
B
O


ATOM
15236
N
LEU
B
420
43.961
28.840
−11.271
1.00
21.94
B
N


ATOM
15237
CA
LEU
B
420
44.408
27.760
−12.166
1.00
21.70
B
C


ATOM
15239
CB
LEU
B
420
45.147
26.654
−11.400
1.00
21.08
B
C


ATOM
15242
CG
LEU
B
420
46.618
26.901
−11.057
1.00
20.18
B
C


ATOM
15244
CD1
LEU
B
420
47.124
25.869
−10.057
1.00
18.62
B
C


ATOM
15248
CD2
LEU
B
420
47.477
26.901
−12.313
1.00
17.37
B
C


ATOM
15252
C
LEU
B
420
43.228
27.145
−12.903
1.00
22.21
B
C


ATOM
15253
O
LEU
B
420
43.283
26.956
−14.118
1.00
22.19
B
O


ATOM
15255
N
GLN
B
421
42.166
26.832
−12.160
1.00
22.92
B
N


ATOM
15256
CA
GLN
B
421
40.958
26.240
−12.739
1.00
23.57
B
C


ATOM
15258
CB
GLN
B
421
39.911
25.943
−11.656
1.00
24.09
B
C


ATOM
15261
CG
GLN
B
421
40.296
24.803
−10.706
1.00
26.83
B
C


ATOM
15264
CD
GLN
B
421
39.112
23.933
−10.302
1.00
29.79
B
C


ATOM
15265
OE1
GLN
B
421
39.061
22.742
−10.627
1.00
31.64
B
O


ATOM
15266
NE2
GLN
B
421
38.151
24.525
−9.597
1.00
29.87
B
N


ATOM
15269
C
GLN
B
421
40.351
27.135
−13.812
1.00
23.57
B
C


ATOM
15270
O
GLN
B
421
39.842
26.637
−14.815
1.00
23.53
B
O


ATOM
15272
N
LYS
B
422
40.430
28.451
−13.605
1.00
24.03
B
N


ATOM
15273
CA
LYS
B
422
39.860
29.436
−14.534
1.00
24.54
B
C


ATOM
15275
CB
LYS
B
422
39.330
30.643
−13.747
1.00
24.69
B
C


ATOM
15278
CG
LYS
B
422
38.068
30.312
−12.950
1.00
27.40
B
C


ATOM
15281
CD
LYS
B
422
37.853
31.231
−11.748
1.00
30.16
B
C


ATOM
15284
CE
LYS
B
422
36.737
30.695
−10.844
1.00
30.51
B
C


ATOM
15287
NZ
LYS
B
422
36.523
31.525
−9.621
1.00
30.84
B
N


ATOM
15291
C
LYS
B
422
40.832
29.882
−15.638
1.00
24.42
B
C


ATOM
15292
O
LYS
B
422
40.546
30.833
−16.366
1.00
24.81
B
O


ATOM
15294
N
TYR
B
423
41.960
29.182
−15.770
1.00
24.16
B
N


ATOM
15295
CA
TYR
B
423
42.965
29.458
−16.803
1.00
23.64
B
C


ATOM
15297
CB
TYR
B
423
42.480
28.982
−18.182
1.00
23.69
B
C


ATOM
15300
CG
TYR
B
423
42.338
27.472
−18.292
1.00
24.59
B
C


ATOM
15301
CD1
TYR
B
423
43.353
26.622
−17.849
1.00
25.56
B
C


ATOM
15303
CE1
TYR
B
423
43.233
25.243
−17.942
1.00
25.98
B
C


ATOM
15305
CZ
TYR
B
423
42.096
24.691
−18.492
1.00
26.45
B
C


ATOM
15306
OH
TYR
B
423
41.994
23.323
−18.576
1.00
26.60
B
O


ATOM
15308
CE2
TYR
B
423
41.073
25.506
−18.948
1.00
26.05
B
C


ATOM
15310
CD2
TYR
B
423
41.200
26.892
−18.848
1.00
25.18
B
C


ATOM
15312
C
TYR
B
423
43.372
30.927
−16.826
1.00
23.30
B
C


ATOM
15313
O
TYR
B
423
43.079
31.657
−17.773
1.00
23.79
B
O


ATOM
15315
N
HIS
B
424
44.058
31.333
−15.762
1.00
22.79
B
N


ATOM
15316
CA
HIS
B
424
44.483
32.715
−15.553
1.00
22.25
B
C


ATOM
15318
CB
HIS
B
424
44.798
32.915
−14.065
1.00
22.47
B
C


ATOM
15321
CG
HIS
B
424
45.182
34.313
−13.699
1.00
23.17
B
C


ATOM
15322
ND1
HIS
B
424
46.491
34.738
−13.664
1.00
22.23
B
N


ATOM
15324
CE1
HIS
B
424
46.531
36.009
−13.308
1.00
22.45
B
C


ATOM
15326
NE2
HIS
B
424
45.294
36.424
−13.106
1.00
23.39
B
N


ATOM
15328
CD2
HIS
B
424
44.430
35.381
−13.342
1.00
23.99
B
C


ATOM
15330
C
HIS
B
424
45.701
33.058
−16.415
1.00
21.56
B
C


ATOM
15331
O
HIS
B
424
46.434
32.167
−16.845
1.00
21.55
B
O


ATOM
15333
N
ASP
B
425
45.898
34.354
−16.659
1.00
21.01
B
N


ATOM
15334
CA
ASP
B
425
47.006
34.875
−17.482
1.00
20.76
B
C


ATOM
15336
CB
ASP
B
425
47.157
36.385
−17.267
1.00
20.81
B
C


ATOM
15339
CG
ASP
B
425
45.982
37.171
−17.801
1.00
21.95
B
C


ATOM
15340
OD1
ASP
B
425
45.764
37.140
−19.030
1.00
23.03
B
O


ATOM
15341
OD2
ASP
B
425
45.281
37.822
−16.994
1.00
22.61
B
O


ATOM
15342
C
ASP
B
425
48.365
34.217
−17.228
1.00
20.21
B
C


ATOM
15343
O
ASP
B
425
49.082
33.880
−18.172
1.00
20.00
B
O


ATOM
15345
N
THR
B
426
48.711
34.052
−15.952
1.00
19.50
B
N


ATOM
15346
CA
THR
B
426
50.011
33.510
−15.545
1.00
18.64
B
C


ATOM
15348
CB
THR
B
426
50.061
33.267
−14.021
1.00
18.27
B
C


ATOM
15350
OG1
THR
B
426
50.051
34.525
−13.335
1.00
17.93
B
O


ATOM
15352
CG2
THR
B
426
51.313
32.502
−13.632
1.00
17.94
B
C


ATOM
15356
C
THR
B
426
50.362
32.216
−16.278
1.00
18.30
B
C


ATOM
15357
O
THR
B
426
51.519
32.012
−16.657
1.00
18.29
B
O


ATOM
15359
N
ILE
B
427
49.364
31.355
−16.479
1.00
17.83
B
N


ATOM
15360
CA
ILE
B
427
49.556
30.106
−17.222
1.00
17.71
B
C


ATOM
15362
CB
ILE
B
427
48.948
28.885
−16.472
1.00
17.30
B
C


ATOM
15364
CG1
ILE
B
427
47.417
28.906
−16.489
1.00
16.67
B
C


ATOM
15367
CD1
ILE
B
427
46.803
27.717
−15.792
1.00
15.11
B
C


ATOM
15371
CG2
ILE
B
427
49.449
28.846
−15.039
1.00
16.16
B
C


ATOM
15375
C
ILE
B
427
49.025
30.172
−18.663
1.00
18.09
B
C


ATOM
15376
O
ILE
B
427
49.557
29.498
−19.547
1.00
17.89
B
O


ATOM
15378
N
SER
B
428
47.997
30.985
−18.904
1.00
18.49
B
N


ATOM
15379
CA
SER
B
428
47.379
31.056
−20.232
1.00
18.89
B
C


ATOM
15381
CB
SER
B
428
46.036
31.794
−20.180
1.00
19.00
B
C


ATOM
15384
OG
SER
B
428
46.211
33.200
−20.223
1.00
19.67
B
O


ATOM
15386
C
SER
B
428
48.296
31.721
−21.255
1.00
19.28
B
C


ATOM
15387
O
SER
B
428
48.416
31.245
−22.382
1.00
19.91
B
O


ATOM
15389
N
ARG
B
429
48.940
32.818
−20.858
1.00
19.47
B
N


ATOM
15390
CA
ARG
B
429
49.798
33.597
−21.763
1.00
19.36
B
C


ATOM
15392
CB
ARG
B
429
50.349
34.838
−21.056
1.00
19.70
B
C


ATOM
15395
CG
ARG
B
429
49.283
35.843
−20.642
1.00
22.63
B
C


ATOM
15398
CD
ARG
B
429
49.315
37.104
−21.490
1.00
25.32
B
C


ATOM
15401
NE
ARG
B
429
48.208
38.001
−21.157
1.00
26.37
B
N


ATOM
15403
CZ
ARG
B
429
47.010
37.998
−21.745
1.00
27.17
B
C


ATOM
15404
NH1
ARG
B
429
46.725
37.144
−22.725
1.00
26.90
B
N


ATOM
15407
NH2
ARG
B
429
46.084
38.865
−21.349
1.00
28.32
B
N


ATOM
15410
C
ARG
B
429
50.948
32.784
−22.364
1.00
18.47
B
C


ATOM
15411
O
ARG
B
429
51.117
32.783
−23.577
1.00
17.94
B
O


ATOM
15413
N
PRO
B
430
51.742
32.087
−21.528
1.00
18.01
B
N


ATOM
15414
CA
PRO
B
430
52.794
31.255
−22.123
1.00
17.76
B
C


ATOM
15416
CB
PRO
B
430
53.597
30.774
−20.909
1.00
17.79
B
C


ATOM
15419
CG
PRO
B
430
52.661
30.880
−19.766
1.00
18.19
B
C


ATOM
15422
CD
PRO
B
430
51.791
32.058
−20.056
1.00
17.89
B
C


ATOM
15425
C
PRO
B
430
52.255
30.068
−22.933
1.00
17.32
B
C


ATOM
15426
O
PRO
B
430
52.989
29.504
−23.746
1.00
17.56
B
O


ATOM
15427
N
SER
B
431
50.996
29.693
−22.710
1.00
16.49
B
N


ATOM
15428
CA
SER
B
431
50.328
28.702
−23.554
1.00
16.00
B
C


ATOM
15430
CB
SER
B
431
49.131
28.086
−22.830
1.00
15.98
B
C


ATOM
15433
OG
SER
B
431
49.521
27.553
−21.578
1.00
15.79
B
O


ATOM
15435
C
SER
B
431
49.896
29.310
−24.895
1.00
15.50
B
C


ATOM
15436
O
SER
B
431
49.769
28.595
−25.890
1.00
15.19
B
O


ATOM
15438
N
HIS
B
432
49.662
30.623
−24.919
1.00
15.14
B
N


ATOM
15439
CA
HIS
B
432
49.510
31.350
−26.183
1.00
14.91
B
C


ATOM
15441
CB
HIS
B
432
49.203
32.841
−25.952
1.00
14.78
B
C


ATOM
15444
CG
HIS
B
432
47.812
33.122
−25.471
1.00
14.57
B
C


ATOM
15445
ND1
HIS
B
432
47.099
32.248
−24.679
1.00
15.65
B
N


ATOM
15447
CE1
HIS
B
432
45.914
32.766
−24.408
1.00
14.74
B
C


ATOM
15449
NE2
HIS
B
432
45.836
33.951
−24.985
1.00
13.39
B
N


ATOM
15451
CD2
HIS
B
432
47.013
34.200
−25.650
1.00
14.77
B
C


ATOM
15453
C
HIS
B
432
50.807
31.224
−26.984
1.00
14.58
B
C


ATOM
15454
O
HIS
B
432
50.786
30.909
−28.172
1.00
14.38
B
O


ATOM
15456
N
ILE
B
433
51.931
31.455
−26.307
1.00
14.30
B
N


ATOM
15457
CA
ILE
B
433
53.258
31.391
−26.919
1.00
13.69
B
C


ATOM
15459
CB
ILE
B
433
54.357
31.939
−25.968
1.00
13.55
B
C


ATOM
15461
CG1
ILE
B
433
54.064
33.386
−25.550
1.00
13.14
B
C


ATOM
15464
CD1
ILE
B
433
54.088
34.380
−26.682
1.00
11.73
B
C


ATOM
15468
CG2
ILE
B
433
55.734
31.857
−26.623
1.00
13.05
B
C


ATOM
15472
C
ILE
B
433
53.627
29.958
−27.303
1.00
13.75
B
C


ATOM
15473
O
ILE
B
433
54.393
29.743
−28.240
1.00
14.58
B
O


ATOM
15475
N
PHE
B
434
53.088
28.982
−26.578
1.00
13.11
B
N


ATOM
15476
CA
PHE
B
434
53.363
27.570
−26.851
1.00
12.79
B
C


ATOM
15478
CB
PHE
B
434
52.916
26.726
−25.648
1.00
12.75
B
C


ATOM
15481
CG
PHE
B
434
53.066
25.231
−25.822
1.00
13.16
B
C


ATOM
15482
CD1
PHE
B
434
53.915
24.668
−26.771
1.00
13.37
B
C


ATOM
15484
CE1
PHE
B
434
54.026
23.285
−26.894
1.00
13.68
B
C


ATOM
15486
CZ
PHE
B
434
53.311
22.454
−26.049
1.00
12.83
B
C


ATOM
15488
CE2
PHE
B
434
52.482
23.002
−25.092
1.00
13.60
B
C


ATOM
15490
CD2
PHE
B
434
52.367
24.379
−24.978
1.00
14.39
B
C


ATOM
15492
C
PHE
B
434
52.689
27.132
−28.153
1.00
12.75
B
C


ATOM
15493
O
PHE
B
434
53.341
26.578
−29.036
1.00
12.94
B
O


ATOM
15495
N
ARG
B
435
51.397
27.409
−28.278
1.00
12.65
B
N


ATOM
15496
CA
ARG
B
435
50.647
27.077
−29.490
1.00
12.43
B
C


ATOM
15498
CB
ARG
B
435
49.146
27.269
−29.238
1.00
12.62
B
C


ATOM
15501
CG
ARG
B
435
48.244
27.150
−30.463
1.00
13.62
B
C


ATOM
15504
CD
ARG
B
435
48.426
25.839
−31.211
1.00
15.01
B
C


ATOM
15507
NE
ARG
B
435
48.056
24.675
−30.411
1.00
15.74
B
N


ATOM
15509
CZ
ARG
B
435
48.332
23.415
−30.739
1.00
17.48
B
C


ATOM
15510
NH1
ARG
B
435
48.997
23.124
−31.856
1.00
18.48
B
N


ATOM
15513
NH2
ARG
B
435
47.948
22.434
−29.936
1.00
18.57
B
N


ATOM
15516
C
ARG
B
435
51.098
27.898
−30.708
1.00
12.48
B
C


ATOM
15517
O
ARG
B
435
51.168
27.370
−31.817
1.00
12.61
B
O


ATOM
15519
N
LEU
B
436
51.401
29.180
−30.504
1.00
12.45
B
N


ATOM
15520
CA
LEU
B
436
51.812
30.060
−31.606
1.00
12.32
B
C


ATOM
15522
CB
LEU
B
436
51.884
31.521
−31.153
1.00
12.22
B
C


ATOM
15525
CG
LEU
B
436
50.576
32.303
−31.063
1.00
11.85
B
C


ATOM
15527
CD1
LEU
B
436
50.876
33.761
−30.737
1.00
12.49
B
C


ATOM
15531
CD2
LEU
B
436
49.782
32.196
−32.351
1.00
11.29
B
C


ATOM
15535
C
LEU
B
436
53.153
29.669
−32.225
1.00
12.83
B
C


ATOM
15536
O
LEU
B
436
53.335
29.800
−33.433
1.00
12.98
B
O


ATOM
15538
N
CYS
B
437
54.093
29.214
−31.402
1.00
13.39
B
N


ATOM
15539
CA
CYS
B
437
55.387
28.759
−31.903
1.00
13.88
B
C


ATOM
15541
CB
CYS
B
437
56.381
28.581
−30.753
1.00
13.94
B
C


ATOM
15544
SG
CYS
B
437
56.826
30.125
−29.910
1.00
15.60
B
S


ATOM
15546
C
CYS
B
437
55.219
27.449
−32.668
1.00
14.16
B
C


ATOM
15547
O
CYS
B
437
55.625
27.343
−33.825
1.00
14.34
B
O


ATOM
15549
N
ASN
B
438
54.602
26.466
−32.014
1.00
14.40
B
N


ATOM
15550
CA
ASN
B
438
54.336
25.156
−32.612
1.00
14.88
B
C


ATOM
15552
CB
ASN
B
438
53.450
24.324
−31.674
1.00
15.18
B
C


ATOM
15555
CG
ASN
B
438
52.919
23.050
−32.324
1.00
16.21
B
C


ATOM
15556
OD1
ASN
B
438
51.766
22.669
−32.104
1.00
17.51
B
O


ATOM
15557
ND2
ASN
B
438
53.754
22.387
−33.122
1.00
16.34
B
N


ATOM
15560
C
ASN
B
438
53.687
25.252
−33.991
1.00
14.99
B
C


ATOM
15561
O
ASN
B
438
54.140
24.613
−34.941
1.00
15.21
B
O


ATOM
15563
N
ASP
B
439
52.623
26.042
−34.091
1.00
15.13
B
N


ATOM
15564
CA
ASP
B
439
51.912
26.202
−35.358
1.00
15.33
B
C


ATOM
15566
CB
ASP
B
439
50.546
26.880
−35.147
1.00
15.20
B
C


ATOM
15569
CG
ASP
B
439
49.512
25.946
−34.501
1.00
14.78
B
C


ATOM
15570
OD1
ASP
B
439
49.909
24.940
−33.876
1.00
13.59
B
O


ATOM
15571
OD2
ASP
B
439
48.295
26.218
−34.619
1.00
13.26
B
O


ATOM
15572
C
ASP
B
439
52.767
26.968
−36.374
1.00
15.73
B
C


ATOM
15573
O
ASP
B
439
52.689
26.698
−37.574
1.00
15.79
B
O


ATOM
15575
N
LEU
B
440
53.587
27.904
−35.892
1.00
16.14
B
N


ATOM
15576
CA
LEU
B
440
54.514
28.640
−36.761
1.00
16.51
B
C


ATOM
15578
CB
LEU
B
440
55.158
29.824
−36.031
1.00
16.13
B
C


ATOM
15581
CG
LEU
B
440
54.414
31.156
−36.092
1.00
15.62
B
C


ATOM
15583
CD1
LEU
B
440
55.083
32.170
−35.174
1.00
15.61
B
C


ATOM
15587
CD2
LEU
B
440
54.358
31.676
−37.520
1.00
14.42
B
C


ATOM
15591
C
LEU
B
440
55.611
27.737
−37.316
1.00
17.37
B
C


ATOM
15592
O
LEU
B
440
56.085
27.949
−38.432
1.00
18.00
B
O


ATOM
15594
N
ALA
B
441
56.017
26.742
−36.534
1.00
18.07
B
N


ATOM
15595
CA
ALA
B
441
57.053
25.804
−36.962
1.00
18.79
B
C


ATOM
15597
CB
ALA
B
441
57.436
24.880
−35.814
1.00
18.94
B
C


ATOM
15601
C
ALA
B
441
56.608
24.984
−38.173
1.00
19.39
B
C


ATOM
15602
O
ALA
B
441
57.367
24.821
−39.130
1.00
19.34
B
O


ATOM
15604
N
SER
B
442
55.372
24.488
−38.129
1.00
20.04
B
N


ATOM
15605
CA
SER
B
442
54.835
23.620
−39.178
1.00
20.72
B
C


ATOM
15607
CB
SER
B
442
54.010
22.503
−38.537
1.00
20.68
B
C


ATOM
15610
OG
SER
B
442
52.872
23.030
−37.876
1.00
21.27
B
O


ATOM
15612
C
SER
B
442
53.970
24.359
−40.208
1.00
21.39
B
C


ATOM
15613
O
SER
B
442
53.341
23.722
−41.055
1.00
21.51
B
O


ATOM
15615
N
ALA
B
443
53.953
25.690
−40.147
1.00
22.14
B
N


ATOM
15616
CA
ALA
B
443
53.036
26.503
−40.957
1.00
22.64
B
C


ATOM
15618
CB
ALA
B
443
53.249
27.988
−40.666
1.00
22.67
B
C


ATOM
15622
C
ALA
B
443
53.139
26.241
−42.463
1.00
22.85
B
C


ATOM
15623
O
ALA
B
443
52.206
25.712
−43.068
1.00
22.40
B
O


ATOM
15625
N
SER
B
444
54.274
26.603
−43.056
1.00
23.46
B
N


ATOM
15626
CA
SER
B
444
54.460
26.513
−44.509
1.00
24.13
B
C


ATOM
15628
CB
SER
B
444
55.851
27.015
−44.903
1.00
24.32
B
C


ATOM
15631
OG
SER
B
444
56.864
26.161
−44.398
1.00
25.37
B
O


ATOM
15633
C
SER
B
444
54.251
25.097
−45.053
1.00
24.33
B
C


ATOM
15634
O
SER
B
444
53.795
24.925
−46.184
1.00
24.33
B
O


ATOM
15636
N
ALA
B
445
54.595
24.093
−44.249
1.00
24.60
B
N


ATOM
15637
CA
ALA
B
445
54.375
22.696
−44.615
1.00
24.55
B
C


ATOM
15639
CB
ALA
B
445
55.038
21.770
−43.601
1.00
24.40
B
C


ATOM
15643
C
ALA
B
445
52.881
22.400
−44.706
1.00
24.64
B
C


ATOM
15644
O
ALA
B
445
52.380
22.032
−45.767
1.00
24.53
B
O


ATOM
15646
N
GLU
B
446
52.176
22.587
−43.593
1.00
24.83
B
N


ATOM
15647
CA
GLU
B
446
50.743
22.289
−43.516
1.00
25.12
B
C


ATOM
15649
CB
GLU
B
446
50.230
22.457
−42.075
1.00
25.24
B
C


ATOM
15652
CG
GLU
B
446
50.805
21.427
−41.088
1.00
26.42
B
C


ATOM
15655
CD
GLU
B
446
50.271
21.565
−39.660
1.00
27.29
B
C


ATOM
15656
OE1
GLU
B
446
49.633
22.589
−39.336
1.00
29.11
B
O


ATOM
15657
OE2
GLU
B
446
50.500
20.638
−38.853
1.00
26.37
B
O


ATOM
15658
C
GLU
B
446
49.912
23.137
−44.488
1.00
25.03
B
C


ATOM
15659
O
GLU
B
446
48.903
22.667
−45.013
1.00
25.21
B
O


ATOM
15661
N
ILE
B
447
50.343
24.373
−44.734
1.00
24.84
B
N


ATOM
15662
CA
ILE
B
447
49.633
25.274
−45.647
1.00
24.77
B
C


ATOM
15664
CB
ILE
B
447
50.218
26.709
−45.600
1.00
24.76
B
C


ATOM
15666
CG1
ILE
B
447
49.850
27.386
−44.276
1.00
24.75
B
C


ATOM
15669
CD1
ILE
B
447
50.783
28.510
−43.879
1.00
24.00
B
C


ATOM
15673
CG2
ILE
B
447
49.706
27.547
−46.771
1.00
23.20
B
C


ATOM
15677
C
ILE
B
447
49.653
24.752
−47.085
1.00
25.09
B
C


ATOM
15678
O
ILE
B
447
48.612
24.699
−47.742
1.00
25.20
B
O


ATOM
15680
N
ALA
B
448
50.835
24.358
−47.560
1.00
25.30
B
N


ATOM
15681
CA
ALA
B
448
51.005
23.871
−48.935
1.00
25.10
B
C


ATOM
15683
CB
ALA
B
448
52.485
23.792
−49.294
1.00
24.84
B
C


ATOM
15687
C
ALA
B
448
50.323
22.521
−49.183
1.00
25.08
B
C


ATOM
15688
O
ALA
B
448
50.005
22.192
−50.324
1.00
25.19
B
O


ATOM
15690
N
ARG
B
449
50.106
21.745
−48.121
1.00
25.21
B
N


ATOM
15691
CA
ARG
B
449
49.342
20.495
−48.214
1.00
25.32
B
C


ATOM
15693
CB
ARG
B
449
49.540
19.636
−46.964
1.00
25.46
B
C


ATOM
15696
CG
ARG
B
449
50.959
19.185
−46.680
1.00
25.13
B
C


ATOM
15699
CD
ARG
B
449
50.986
18.373
−45.391
1.00
24.41
B
C


ATOM
15702
NE
ARG
B
449
52.221
18.551
−44.632
1.00
24.69
B
N


ATOM
15704
CZ
ARG
B
449
52.395
18.161
−43.368
1.00
24.86
B
C


ATOM
15705
NH1
ARG
B
449
51.412
17.563
−42.698
1.00
25.32
B
N


ATOM
15708
NH2
ARG
B
449
53.561
18.372
−42.765
1.00
24.17
B
N


ATOM
15711
C
ARG
B
449
47.843
20.749
−48.357
1.00
25.44
B
C


ATOM
15712
O
ARG
B
449
47.103
19.868
−48.793
1.00
25.60
B
O


ATOM
15714
N
GLY
B
450
47.399
21.940
−47.961
1.00
25.52
B
N


ATOM
15715
CA
GLY
B
450
45.978
22.269
−47.919
1.00
25.45
B
C


ATOM
15718
C
GLY
B
450
45.347
21.972
−46.568
1.00
25.40
B
C


ATOM
15719
O
GLY
B
450
44.125
21.849
−46.471
1.00
25.56
B
O


ATOM
15721
N
GLU
B
451
46.171
21.852
−45.525
1.00
25.17
B
N


ATOM
15722
CA
GLU
B
451
45.666
21.675
−44.162
1.00
25.18
B
C


ATOM
15724
CB
GLU
B
451
46.685
20.956
−43.271
1.00
25.44
B
C


ATOM
15727
CG
GLU
B
451
46.811
19.460
−43.546
1.00
26.78
B
C


ATOM
15730
CD
GLU
B
451
47.637
18.724
−42.496
1.00
28.97
B
C


ATOM
15731
OE1
GLU
B
451
47.800
19.2
−41.368
1.00
30.01
B
O


ATOM
15732
OE2
GLU
B
451
48.122
17.6
−42.799
1.00
30.31
B
O


ATOM
15733
C
GLU
B
451
45.308
23.029
−43.551
1.00
24.68
B
C


ATOM
15734
O
GLU
B
451
46.039
24.007
−43.716
1.00
24.69
B
O


ATOM
15736
N
THR
B
452
44.179
23.069
−42.845
1.00
24.05
B
N


ATOM
15737
CA
THR
B
452
43.680
24.299
−42.223
1.00
23.13
B
C


ATOM
15739
CB
THR
B
452
42.176
24.536
−42.552
1.00
23.21
B
C


ATOM
15741
OG1
THR
B
452
41.494
23.281
−42.679
1.00
22.65
B
O


ATOM
15743
CG2
THR
B
452
42.023
25.322
−43.850
1.00
22.06
B
C


ATOM
15747
C
THR
B
452
43.878
24.338
−40.702
1.00
22.26
B
C


ATOM
15748
O
THR
B
452
43.816
25.416
−40.107
1.00
22.08
B
O


ATOM
15750
N
ALA
B
453
44.119
23.182
−40.078
1.00
21.27
B
N


ATOM
15751
CA
ALA
B
453
44.318
23.105
−38.624
1.00
20.51
B
C


ATOM
15753
CB
ALA
B
453
44.174
21.670
−38.137
1.00
20.50
B
C


ATOM
15757
C
ALA
B
453
45.680
23.674
−38.222
1.00
20.10
B
C


ATOM
15758
O
ALA
B
453
46.590
22.946
−37.816
1.00
20.31
B
O


ATOM
15760
N
ASN
B
454
45.793
24.992
−38.343
1.00
19.21
B
N


ATOM
15761
CA
ASN
B
454
46.991
25.736
−37.982
1.00
17.99
B
C


ATOM
15763
CB
ASN
B
454
48.020
25.682
−39.117
1.00
17.83
B
C


ATOM
15766
CG
ASN
B
454
49.386
26.230
−38.709
1.00
17.61
B
C


ATOM
15767
OD1
ASN
B
454
49.581
27.442
−38.617
1.00
17.15
B
O


ATOM
15768
ND2
ASN
B
454
50.341
25.334
−38.485
1.00
16.02
B
N


ATOM
15771
C
ASN
B
454
46.555
27.168
−37.705
1.00
17.02
B
C


ATOM
15772
O
ASN
B
454
45.631
27.671
−38.343
1.00
16.92
B
O


ATOM
15774
N
SER
B
455
47.198
27.816
−36.743
1.00
16.17
B
N


ATOM
15775
CA
SER
B
455
46.830
29.178
−36.373
1.00
15.49
B
C


ATOM
15777
CB
SER
B
455
47.504
29.571
−35.061
1.00
15.49
B
C


ATOM
15780
OG
SER
B
455
47.026
28.759
−34.002
1.00
15.01
B
O


ATOM
15782
C
SER
B
455
47.165
30.177
−37.482
1.00
15.01
B
C


ATOM
15783
O
SER
B
455
46.369
31.068
−37.780
1.00
14.87
B
O


ATOM
15785
N
VAL
B
456
48.331
30.015
−38.104
1.00
14.62
B
N


ATOM
15786
CA
VAL
B
456
48.729
30.885
−39.214
1.00
14.23
B
C


ATOM
15788
CB
VAL
B
456
50.186
30.623
−39.660
1.00
13.71
B
C


ATOM
15790
CG1
VAL
B
456
50.564
31.530
−40.820
1.00
12.75
B
C


ATOM
15794
CG2
VAL
B
456
51.140
30.836
−38.498
1.00
12.43
B
C


ATOM
15798
C
VAL
B
456
47.769
30.725
−40.399
1.00
14.74
B
C


ATOM
15799
O
VAL
B
456
47.520
31.682
−41.133
1.00
15.01
B
O


ATOM
15801
N
SER
B
457
47.228
29.521
−40.573
1.00
15.08
B
N


ATOM
15802
CA
SER
B
457
46.194
29.275
−41.579
1.00
15.28
B
C


ATOM
15804
CB
SER
B
457
45.918
27.775
−41.728
1.00
15.22
B
C


ATOM
15807
OG
SER
B
457
44.712
27.543
−42.437
1.00
15.09
B
O


ATOM
15809
C
SER
B
457
44.902
30.009
−41.227
1.00
15.53
B
C


ATOM
15810
O
SER
B
457
44.311
30.663
−42.082
1.00
15.71
B
O


ATOM
15812
N
CYS
B
458
44.469
29.893
−39.973
1.00
15.80
B
N


ATOM
15813
CA
CYS
B
458
43.245
30.559
−39.515
1.00
16.11
B
C


ATOM
15815
CB
CYS
B
458
42.912
30.183
−38.070
1.00
15.87
B
C


ATOM
15818
SG
CYS
B
458
42.128
28.572
−37.880
1.00
18.08
B
S


ATOM
15820
C
CYS
B
458
43.354
32.072
−39.628
1.00
16.21
B
C


ATOM
15821
O
CYS
B
458
42.379
32.744
−39.968
1.00
17.07
B
O


ATOM
15823
N
TYR
B
459
44.539
32.602
−39.342
1.00
15.90
B
N


ATOM
15824
CA
TYR
B
459
44.771
34.039
−39.424
1.00
15.53
B
C


ATOM
15826
CB
TYR
B
459
46.084
34.420
−38.727
1.00
15.20
B
C


ATOM
15829
CG
TYR
B
459
46.116
35.848
−38.221
1.00
13.77
B
C


ATOM
15830
CD1
TYR
B
459
45.880
36.142
−36.880
1.00
11.99
B
C


ATOM
15832
CE1
TYR
B
459
45.906
37.452
−36.416
1.00
10.67
B
C


ATOM
15834
CZ
TYR
B
459
46.170
38.483
−37.298
1.00
10.73
B
C


ATOM
15835
OH
TYR
B
459
46.202
39.785
−36.855
1.00
12.04
B
O


ATOM
15837
CE2
TYR
B
459
46.406
38.216
−38.630
1.00
11.92
B
C


ATOM
15839
CD2
TYR
B
459
46.376
36.906
−39.086
1.00
13.04
B
C


ATOM
15841
C
TYR
B
459
44.765
34.507
−40.884
1.00
15.64
B
C


ATOM
15842
O
TYR
B
459
44.354
35.630
−41.171
1.00
15.37
B
O


ATOM
15844
N
MET
B
460
45.209
33.646
−41.798
1.00
16.17
B
N


ATOM
15845
CA
MET
B
460
45.137
33.935
−43.234
1.00
17.10
B
C


ATOM
15847
CB
MET
B
460
45.871
32.865
−44.049
1.00
17.68
B
C


ATOM
15850
CG
MET
B
460
47.381
33.004
−44.070
1.00
20.00
B
C


ATOM
15853
SD
MET
B
460
48.194
31.536
−44.746
1.00
24.41
B
S


ATOM
15854
CE
MET
B
460
47.441
31.432
−46.371
1.00
21.79
B
C


ATOM
15858
C
MET
B
460
43.690
34.021
−43.726
1.00
17.18
B
C


ATOM
15859
O
MET
B
460
43.328
34.962
−44.434
1.00
17.43
B
O


ATOM
15861
N
ARG
B
461
42.877
33.031
−43.359
1.00
17.00
B
N


ATOM
15862
CA
ARG
B
461
41.472
32.966
−43.784
1.00
16.70
B
C


ATOM
15864
CB
ARG
B
461
40.848
31.623
−43.399
1.00
16.92
B
C


ATOM
15867
CG
ARG
B
461
41.012
30.525
−44.433
1.00
17.73
B
C


ATOM
15870
CD
ARG
B
461
40.488
29.211
−43.879
1.00
19.18
B
C


ATOM
15873
NE
ARG
B
461
41.337
28.716
−42.794
1.00
19.69
B
N


ATOM
15875
CZ
ARG
B
461
40.942
27.907
−41.810
1.00
20.75
B
C


ATOM
15876
NH1
ARG
B
461
39.687
27.474
−41.729
1.00
20.89
B
N


ATOM
15879
NH2
ARG
B
461
41.819
27.534
−40.886
1.00
22.40
B
N


ATOM
15882
C
ARG
B
461
40.621
34.079
−43.186
1.00
16.22
B
C


ATOM
15883
O
ARG
B
461
39.803
34.683
−43.879
1.00
16.34
B
O


ATOM
15885
N
THR
B
462
40.807
34.330
−41.895
1.00
15.74
B
N


ATOM
15886
CA
THR
B
462
40.008
35.317
−41.181
1.00
15.73
B
C


ATOM
15888
CB
THR
B
462
40.255
35.228
−39.672
1.00
15.53
B
C


ATOM
15890
OG1
THR
B
462
39.962
33.900
−39.224
1.00
15.96
B
O


ATOM
15892
CG2
THR
B
462
39.379
36.217
−38.924
1.00
16.51
B
C


ATOM
15896
C
THR
B
462
40.261
36.749
−41.649
1.00
15.94
B
C


ATOM
15897
O
THR
B
462
39.322
37.532
−41.801
1.00
16.24
B
O


ATOM
15899
N
LYS
B
463
41.527
37.084
−41.876
1.00
15.98
B
N


ATOM
15900
CA
LYS
B
463
41.906
38.423
−42.316
1.00
16.21
B
C


ATOM
15902
CB
LYS
B
463
43.232
38.827
−41.672
1.00
16.41
B
C


ATOM
15905
CG
LYS
B
463
43.165
38.978
−40.152
1.00
16.93
B
C


ATOM
15908
CD
LYS
B
463
42.539
40.306
−39.738
1.00
16.56
B
C


ATOM
15911
CE
LYS
B
463
42.716
40.567
−38.251
1.00
16.16
B
C


ATOM
15914
NZ
LYS
B
463
42.453
41.992
−37.910
1.00
15.98
B
N


ATOM
15918
C
LYS
B
463
42.010
38.525
−43.838
1.00
16.35
B
C


ATOM
15919
O
LYS
B
463
42.119
39.628
−44.379
1.00
16.35
B
O


ATOM
15921
N
GLY
B
464
41.977
37.381
−44.520
1.00
16.54
B
N


ATOM
15922
CA
GLY
B
464
42.063
37.340
−45.978
1.00
16.78
B
C


ATOM
15925
C
GLY
B
464
43.348
37.955
−46.500
1.00
17.14
B
C


ATOM
15926
O
GLY
B
464
43.316
38.779
−47.415
1.00
17.35
B
O


ATOM
15928
N
ILE
B
465
44.477
37.550
−45.917
1.00
17.39
B
N


ATOM
15929
CA
ILE
B
465
45.789
38.112
−46.265
1.00
17.68
B
C


ATOM
15931
CB
ILE
B
465
46.356
39.000
−45.122
1.00
17.52
B
C


ATOM
15933
CG1
ILE
B
465
46.503
38.208
−43.818
1.00
16.22
B
C


ATOM
15936
CD1
ILE
B
465
47.122
39.001
−42.698
1.00
13.96
B
C


ATOM
15940
CG2
ILE
B
465
45.457
40.206
−44.901
1.00
18.60
B
C


ATOM
15944
C
ILE
B
465
46.802
37.022
−46.626
1.00
18.16
B
C


ATOM
15945
O
ILE
B
465
46.529
35.831
−46.464
1.00
18.09
B
O


ATOM
15947
N
SER
B
466
47.966
37.448
−47.118
1.00
18.79
B
N


ATOM
15948
CA
SER
B
466
49.035
36.535
−47.538
1.00
19.13
B
C


ATOM
15950
CB
SER
B
466
50.103
37.303
−48.318
1.00
19.18
B
C


ATOM
15953
OG
SER
B
466
50.799
38.203
−47.471
1.00
18.23
B
O


ATOM
15955
C
SER
B
466
49.694
35.843
−46.349
1.00
19.60
B
C


ATOM
15956
O
SER
B
466
49.741
36.401
−45.251
1.00
19.64
B
O


ATOM
15958
N
GLU
B
467
50.216
34.637
−46.581
1.00
20.01
B
N


ATOM
15959
CA
GLU
B
467
50.903
33.862
−45.535
1.00
20.44
B
C


ATOM
15961
CB
GLU
B
467
51.440
32.541
−46.106
1.00
20.58
B
C


ATOM
15964
CG
GLU
B
467
52.180
31.664
−45.086
1.00
20.96
B
C


ATOM
15967
CD
GLU
B
467
52.735
30.383
−45.685
1.00
21.70
B
C


ATOM
15968
OE1
GLU
B
467
52.053
29.765
−46.530
1.00
22.54
B
O


ATOM
15969
OE2
GLU
B
467
53.854
29.984
−45.296
1.00
22.39
B
O


ATOM
15970
C
GLU
B
467
52.047
34.650
−44.895
1.00
20.53
B
C


ATOM
15971
O
GLU
B
467
52.293
34.541
−43.692
1.00
20.25
B
O


ATOM
15973
N
GLU
B
468
52.744
35.432
−45.714
1.00
20.89
B
N


ATOM
15974
CA
GLU
B
468
53.826
36.295
−45.253
1.00
21.16
B
C


ATOM
15976
CB
GLU
B
468
54.438
37.025
−46.451
1.00
21.39
B
C


ATOM
15979
CG
GLU
B
468
55.709
37.807
−46.150
1.00
22.77
B
C


ATOM
15982
CD
GLU
B
468
56.147
38.680
−47.317
1.00
25.04
B
C


ATOM
15983
OE1
GLU
B
468
55.474
38.657
−48.373
1.00
26.20
B
O


ATOM
15984
OE2
GLU
B
468
57.164
39.393
−47.179
1.00
26.28
B
O


ATOM
15985
C
GLU
B
468
53.330
37.316
−44.225
1.00
20.91
B
C


ATOM
15986
O
GLU
B
468
53.981
37.540
−43.203
1.00
21.14
B
O


ATOM
15988
N
LEU
B
469
52.179
37.925
−44.507
1.00
20.46
B
N


ATOM
15989
CA
LEU
B
469
51.607
38.964
−43.642
1.00
19.85
B
C


ATOM
15991
CB
LEU
B
469
50.616
39.833
−44.433
1.00
19.93
B
C


ATOM
15994
CG
LEU
B
469
50.541
41.325
−44.088
1.00
19.46
B
C


ATOM
15996
CD1
LEU
B
469
49.630
42.035
−45.081
1.00
19.01
B
C


ATOM
16000
CD2
LEU
B
469
50.071
41.572
−42.657
1.00
18.30
B
C


ATOM
16004
C
LEU
B
469
50.923
38.353
−42.412
1.00
19.10
B
C


ATOM
16005
O
LEU
B
469
50.888
38.969
−41.349
1.00
18.73
B
O


ATOM
16007
N
ALA
B
470
50.374
37.149
−42.565
1.00
18.69
B
N


ATOM
16008
CA
ALA
B
470
49.770
36.427
−41.443
1.00
18.30
B
C


ATOM
16010
CB
ALA
B
470
48.984
35.221
−41.945
1.00
18.19
B
C


ATOM
16014
C
ALA
B
470
50.835
35.987
−40.441
1.00
17.77
B
C


ATOM
16015
O
ALA
B
470
50.624
36.070
−39.230
1.00
17.14
B
O


ATOM
16017
N
THR
B
471
51.970
35.517
−40.961
1.00
17.77
B
N


ATOM
16018
CA
THR
B
471
53.128
35.137
−40.141
1.00
17.92
B
C


ATOM
16020
CB
THR
B
471
54.264
34.553
−41.009
1.00
17.78
B
C


ATOM
16022
OG1
THR
B
471
53.940
33.208
−41.381
1.00
18.24
B
O


ATOM
16024
CG2
THR
B
471
55.586
34.559
−40.261
1.00
17.26
B
C


ATOM
16028
C
THR
B
471
53.670
36.319
−39.337
1.00
18.26
B
C


ATOM
16029
O
THR
B
471
54.011
36.171
−38.164
1.00
18.51
B
O


ATOM
16031
N
GLU
B
472
53.747
37.483
−39.979
1.00
18.50
B
N


ATOM
16032
CA
GLU
B
472
54.144
38.730
−39.322
1.00
18.54
B
C


ATOM
16034
CB
GLU
B
472
54.078
39.882
−40.333
1.00
18.66
B
C


ATOM
16037
CG
GLU
B
472
54.483
41.252
−39.797
1.00
19.75
B
C


ATOM
16040
CD
GLU
B
472
54.306
42.361
−40.825
1.00
20.71
B
C


ATOM
16041
OE1
GLU
B
472
53.611
42.146
−41.843
1.00
18.97
B
O


ATOM
16042
OE2
GLU
B
472
54.864
43.457
−40.610
1.00
22.53
B
O


ATOM
16043
C
GLU
B
472
53.255
39.043
−38.112
1.00
18.37
B
C


ATOM
16044
O
GLU
B
472
53.753
39.376
−37.036
1.00
18.21
B
O


ATOM
16046
N
SER
B
473
51.941
38.931
−38.299
1.00
18.41
B
N


ATOM
16047
CA
SER
B
473
50.970
39.247
−37.248
1.00
18.17
B
C


ATOM
16049
CB
SER
B
473
49.548
39.246
−37.813
1.00
17.98
B
C


ATOM
16052
OG
SER
B
473
49.382
40.280
−38.766
1.00
17.49
B
O


ATOM
16054
C
SER
B
473
51.058
38.289
−36.061
1.00
18.17
B
C


ATOM
16055
O
SER
B
473
50.892
38.704
−34.913
1.00
18.49
B
O


ATOM
16057
N
VAL
B
474
51.314
37.013
−36.339
1.00
17.87
B
N


ATOM
16058
CA
VAL
B
474
51.508
36.026
−35.278
1.00
17.81
B
C


ATOM
16060
CB
VAL
B
474
51.578
34.583
−35.835
1.00
17.80
B
C


ATOM
16062
CG1
VAL
B
474
51.912
33.591
−34.727
1.00
16.61
B
C


ATOM
16066
CG2
VAL
B
474
50.261
34.205
−36.504
1.00
16.90
B
C


ATOM
16070
C
VAL
B
474
52.769
36.341
−34.469
1.00
18.13
B
C


ATOM
16071
O
VAL
B
474
52.783
36.165
−33.253
1.00
18.18
B
O


ATOM
16073
N
MET
B
475
53.817
36.817
−35.139
1.00
18.76
B
N


ATOM
16074
CA
MET
B
475
55.033
37.248
−34.443
1.00
19.47
B
C


ATOM
16076
CB
MET
B
475
56.131
37.658
−35.433
1.00
19.73
B
C


ATOM
16079
CG
MET
B
475
56.654
36.537
−36.319
1.00
20.45
B
C


ATOM
16082
SD
MET
B
475
57.699
35.349
−35.460
1.00
23.17
B
S


ATOM
16083
CE
MET
B
475
58.311
34.392
−36.849
1.00
21.35
B
C


ATOM
16087
C
MET
B
475
54.718
38.423
−33.517
1.00
19.81
B
C


ATOM
16088
O
MET
B
475
55.195
38.471
−32.383
1.00
19.66
B
O


ATOM
16090
N
ASN
B
476
53.912
39.363
−34.009
1.00
20.14
B
N


ATOM
16091
CA
ASN
B
476
53.483
40.518
−33.216
1.00
20.47
B
C


ATOM
16093
CB
ASN
B
476
52.766
41.543
−34.102
1.00
20.65
B
C


ATOM
16096
CG
ASN
B
476
53.699
42.205
−35.101
1.00
21.93
B
C


ATOM
16097
OD1
ASN
B
476
54.734
42.757
−34.726
1.00
24.56
B
O


ATOM
16098
ND2
ASN
B
476
53.333
42.160
−36.379
1.00
22.45
B
N


ATOM
16101
C
ASN
B
476
52.581
40.123
−32.044
1.00
20.49
B
C


ATOM
16102
O
ASN
B
476
52.541
40.815
−31.025
1.00
20.89
B
O


ATOM
16104
N
LEU
B
477
51.862
39.014
−32.195
1.00
20.27
B
N


ATOM
16105
CA
LEU
B
477
51.019
38.481
−31.123
1.00
19.90
B
C


ATOM
16107
CB
LEU
B
477
50.030
37.446
−31.674
1.00
19.84
B
C


ATOM
16110
CG
LEU
B
477
48.636
37.462
−31.046
1.00
19.42
B
C


ATOM
16112
CD1
LEU
B
477
47.908
38.751
−31.411
1.00
18.74
B
C


ATOM
16116
CD2
LEU
B
477
47.841
36.247
−31.494
1.00
18.32
B
C


ATOM
16120
C
LEU
B
477
51.877
37.863
−30.013
1.00
19.60
B
C


ATOM
16121
O
LEU
B
477
51.480
37.864
−28.845
1.00
19.36
B
O


ATOM
16123
N
ILE
B
478
53.045
37.335
−30.386
1.00
19.33
B
N


ATOM
16124
CA
ILE
B
478
54.028
36.846
−29.414
1.00
18.77
B
C


ATOM
16126
CB
ILE
B
478
55.159
36.038
−30.092
1.00
18.25
B
C


ATOM
16128
CG1
ILE
B
478
54.626
34.686
−30.568
1.00
17.56
B
C


ATOM
16131
CD1
ILE
B
478
55.694
33.767
−31.126
1.00
17.90
B
C


ATOM
16135
CG2
ILE
B
478
56.321
35.832
−29.135
1.00
16.88
B
C


ATOM
16139
C
ILE
B
478
54.631
38.007
−28.622
1.00
19.04
B
C


ATOM
16140
O
ILE
B
478
54.677
37.962
−27.393
1.00
19.14
B
O


ATOM
16142
N
ASP
B
479
55.088
39.040
−29.331
1.00
19.19
B
N


ATOM
16143
CA
ASP
B
479
55.605
40.255
−28.694
1.00
19.30
B
C


ATOM
16145
CB
ASP
B
479
55.884
41.345
−29.739
1.00
19.38
B
C


ATOM
16148
CG
ASP
B
479
57.121
41.061
−30.580
1.00
19.94
B
C


ATOM
16149
OD1
ASP
B
479
57.589
39.903
−30.603
1.00
22.59
B
O


ATOM
16150
OD2
ASP
B
479
57.625
42.004
−31.228
1.00
19.87
B
O


ATOM
16151
C
ASP
B
479
54.625
40.792
−27.649
1.00
19.52
B
C


ATOM
16152
O
ASP
B
479
55.007
41.051
−26.506
1.00
19.57
B
O


ATOM
16154
N
GLU
B
480
53.362
40.940
−28.044
1.00
19.62
B
N


ATOM
16155
CA
GLU
B
480
52.332
41.489
−27.156
1.00
19.69
B
C


ATOM
16157
CB
GLU
B
480
51.053
41.813
−27.939
1.00
19.64
B
C


ATOM
16160
CG
GLU
B
480
51.154
43.076
−28.785
1.00
20.42
B
C


ATOM
16163
CD
GLU
B
480
51.566
44.302
−27.976
1.00
21.42
B
C


ATOM
16164
OE1
GLU
B
480
52.363
45.113
−28.490
1.00
21.49
B
O


ATOM
16165
OE2
GLU
B
480
51.104
44.448
−26.823
1.00
21.89
B
O


ATOM
16166
C
GLU
B
480
52.004
40.588
−25.966
1.00
19.49
B
C


ATOM
16167
O
GLU
B
480
51.663
41.085
−24.889
1.00
19.09
B
O


ATOM
16169
N
THR
B
481
52.102
39.274
−26.165
1.00
19.48
B
N


ATOM
16170
CA
THR
B
481
51.921
38.308
−25.077
1.00
19.19
B
C


ATOM
16172
CB
THR
B
481
51.751
36.871
−25.609
1.00
18.82
B
C


ATOM
16174
OG1
THR
B
481
50.430
36.713
−26.142
1.00
17.25
B
O


ATOM
16176
CG2
THR
B
481
51.964
35.856
−24.497
1.00
18.35
B
C


ATOM
16180
C
THR
B
481
53.093
38.359
−24.092
1.00
19.61
B
C


ATOM
16181
O
THR
B
481
52.883
38.329
−22.877
1.00
20.16
B
O


ATOM
16183
N
TRP
B
482
54.318
38.438
−24.613
1.00
19.27
B
N


ATOM
16184
CA
TRP
B
482
55.503
38.600
−23.763
1.00
19.03
B
C


ATOM
16186
CB
TRP
B
482
56.805
38.542
−24.581
1.00
19.10
B
C


ATOM
16189
CG
TRP
B
482
57.389
37.164
−24.652
1.00
19.78
B
C


ATOM
16190
CD1
TRP
B
482
57.235
36.257
−25.660
1.00
20.32
B
C


ATOM
16192
NE1
TRP
B
482
57.906
35.097
−25.360
1.00
20.19
B
N


ATOM
16194
CE2
TRP
B
482
58.509
35.235
−24.137
1.00
20.96
B
C


ATOM
16195
CD2
TRP
B
482
58.203
36.526
−23.660
1.00
20.92
B
C


ATOM
16196
CE3
TRP
B
482
58.704
36.921
−22.413
1.00
20.54
B
C


ATOM
16198
CZ3
TRP
B
482
59.485
36.024
−21.694
1.00
19.83
B
C


ATOM
16200
CH2
TRP
B
482
59.775
34.750
−22.197
1.00
18.86
B
C


ATOM
16202
CZ2
TRP
B
482
59.300
34.336
−23.413
1.00
19.97
B
C


ATOM
16204
C
TRP
B
482
55.439
39.896
−22.960
1.00
18.96
B
C


ATOM
16205
O
TRP
B
482
55.892
39.935
−21.818
1.00
18.99
B
O


ATOM
16207
N
LYS
B
483
54.871
40.945
−23.553
1.00
18.84
B
N


ATOM
16208
CA
LYS
B
483
54.711
42.228
−22.860
1.00
18.72
B
C


ATOM
16210
CB
LYS
B
483
54.188
43.306
−23.818
1.00
18.58
B
C


ATOM
16213
CG
LYS
B
483
55.251
43.895
−24.728
1.00
16.71
B
C


ATOM
16216
CD
LYS
B
483
54.670
44.960
−25.639
1.00
14.83
B
C


ATOM
16219
CE
LYS
B
483
55.692
45.441
−26.649
1.00
13.58
B
C


ATOM
16222
NZ
LYS
B
483
55.245
46.679
−27.324
1.00
11.34
B
N


ATOM
16226
C
LYS
B
483
53.790
42.123
−21.640
1.00
18.92
B
C


ATOM
16227
O
LYS
B
483
53.982
42.829
−20.648
1.00
19.09
B
O


ATOM
16229
N
LYS
B
484
52.799
41.241
−21.717
1.00
18.99
B
N


ATOM
16230
CA
LYS
B
484
51.861
41.039
−20.615
1.00
19.49
B
C


ATOM
16232
CB
LYS
B
484
50.477
40.674
−21.160
1.00
19.74
B
C


ATOM
16235
CG
LYS
B
484
49.839
41.803
−21.979
1.00
20.77
B
C


ATOM
16238
CD
LYS
B
484
48.609
41.336
−22.749
1.00
21.69
B
C


ATOM
16241
CE
LYS
B
484
48.153
42.369
−23.775
1.00
21.40
B
C


ATOM
16244
NZ
LYS
B
484
47.244
41.774
−24.798
1.00
21.11
B
N


ATOM
16248
C
LYS
B
484
52.368
39.992
−19.614
1.00
19.34
B
C


ATOM
16249
O
LYS
B
484
52.050
40.061
−18.427
1.00
19.45
B
O


ATOM
16251
N
MET
B
485
53.157
39.031
−20.089
1.00
19.18
B
N


ATOM
16252
CA
MET
B
485
53.822
38.075
−19.199
1.00
19.15
B
C


ATOM
16254
CB
MET
B
485
54.469
36.941
−19.992
1.00
18.98
B
C


ATOM
16257
CG
MET
B
485
53.499
35.902
−20.500
1.00
18.28
B
C


ATOM
16260
SD
MET
B
485
54.363
34.436
−21.072
1.00
16.65
B
S


ATOM
16261
CE
MET
B
485
55.425
35.132
−22.337
1.00
16.32
B
C


ATOM
16265
C
MET
B
485
54.897
38.750
−18.353
1.00
19.51
B
C


ATOM
16266
O
MET
B
485
55.082
38.397
−17.190
1.00
19.86
B
O


ATOM
16268
N
ASN
B
486
55.615
39.700
−18.949
1.00
19.82
B
N


ATOM
16269
CA
ASN
B
486
56.642
40.457
−18.234
1.00
20.17
B
C


ATOM
16271
CB
ASN
B
486
57.353
41.434
−19.175
1.00
20.23
B
C


ATOM
16274
CG
ASN
B
486
58.260
40.739
−20.174
1.00
20.22
B
C


ATOM
16275
OD1
ASN
B
486
58.679
39.597
−19.968
1.00
18.04
B
O


ATOM
16276
ND2
ASN
B
486
58.570
41.432
−21.267
1.00
18.35
B
N


ATOM
16279
C
ASN
B
486
56.073
41.225
−17.046
1.00
20.79
B
C


ATOM
16280
O
ASN
B
486
56.712
41.302
−15.994
1.00
20.97
B
O


ATOM
16282
N
LYS
B
487
54.878
41.792
−17.221
1.00
21.29
B
N


ATOM
16283
CA
LYS
B
487
54.199
42.524
−16.147
1.00
21.50
B
C


ATOM
16285
CB
LYS
B
487
52.967
43.266
−16.678
1.00
21.48
B
C


ATOM
16288
CG
LYS
B
487
52.281
44.137
−15.630
1.00
22.59
B
C


ATOM
16291
CD
LYS
B
487
51.063
44.853
−16.184
1.00
25.14
B
C


ATOM
16294
CE
LYS
B
487
50.218
45.453
−15.064
1.00
26.24
B
C


ATOM
16297
NZ
LYS
B
487
48.974
46.098
−15.571
1.00
27.02
B
N


ATOM
16301
C
LYS
B
487
53.789
41.596
−15.005
1.00
21.42
B
C


ATOM
16302
O
LYS
B
487
53.830
41.990
−13.841
1.00
21.42
B
O


ATOM
16304
N
GLU
B
488
53.397
40.371
−15.346
1.00
21.59
B
N


ATOM
16305
CA
GLU
B
488
52.999
39.373
−14.350
1.00
21.83
B
C


ATOM
16307
CB
GLU
B
488
52.583
38.064
−15.035
1.00
21.81
B
C


ATOM
16310
CG
GLU
B
488
51.557
37.253
−14.256
1.00
21.26
B
C


ATOM
16313
CD
GLU
B
488
50.179
37.886
−14.273
1.00
19.11
B
C


ATOM
16314
OE1
GLU
B
488
49.566
38.007
−13.191
1.00
20.01
B
O


ATOM
16315
OE2
GLU
B
488
49.713
38.270
−15.365
1.00
14.89
B
O


ATOM
16316
C
GLU
B
488
54.134
39.104
−13.359
1.00
22.01
B
C


ATOM
16317
O
GLU
B
488
53.948
39.212
−12.145
1.00
22.27
B
O


ATOM
16319
N
LYS
B
489
55.308
38.772
−13.894
1.00
21.89
B
N


ATOM
16320
CA
LYS
B
489
56.502
38.503
−13.087
1.00
21.65
B
C


ATOM
16322
CB
LYS
B
489
57.658
38.066
−13.995
1.00
21.41
B
C


ATOM
16325
CG
LYS
B
489
58.974
37.757
−13.282
1.00
20.79
B
C


ATOM
16328
CD
LYS
B
489
58.858
36.558
−12.349
1.00
19.77
B
C


ATOM
16331
CE
LYS
B
489
60.160
36.303
−11.605
1.00
19.39
B
C


ATOM
16334
NZ
LYS
B
489
61.314
36.125
−12.527
1.00
18.60
B
N


ATOM
16338
C
LYS
B
489
56.932
39.715
−12.260
1.00
21.80
B
C


ATOM
16339
O
LYS
B
489
57.425
39.566
−11.140
1.00
21.96
B
O


ATOM
16341
N
LEU
B
490
56.749
40.908
−12.820
1.00
21.81
B
N


ATOM
16342
CA
LEU
B
490
57.145
42.143
−12.149
1.00
21.84
B
C


ATOM
16344
CB
LEU
B
490
56.972
43.349
−13.084
1.00
21.72
B
C


ATOM
16347
CG
LEU
B
490
58.111
44.369
−13.049
1.00
21.17
B
C


ATOM
16349
CD1
LEU
B
490
59.318
43.812
−13.782
1.00
20.00
B
C


ATOM
16353
CD2
LEU
B
490
57.681
45.699
−13.651
1.00
20.57
B
C


ATOM
16357
C
LEU
B
490
56.322
42.338
−10.878
1.00
22.21
B
C


ATOM
16358
O
LEU
B
490
56.868
42.627
−9.812
1.00
22.30
B
O


ATOM
16360
N
GLY
B
491
55.009
42.163
−11.001
1.00
22.57
B
N


ATOM
16361
CA
GLY
B
491
54.092
42.349
−9.881
1.00
22.97
B
C


ATOM
16364
C
GLY
B
491
52.644
42.326
−10.332
1.00
23.45
B
C


ATOM
16365
O
GLY
B
491
52.356
42.365
−11.528
1.00
23.60
B
O


ATOM
16367
N
GLY
B
492
51.727
42.281
−9.372
1.00
23.88
B
N


ATOM
16368
CA
GLY
B
492
50.315
42.067
−9.672
1.00
24.35
B
C


ATOM
16371
C
GLY
B
492
50.083
40.618
−10.053
1.00
24.84
B
C


ATOM
16372
O
GLY
B
492
49.210
40.308
−10.867
1.00
24.78
B
O


ATOM
16374
N
SER
B
493
50.882
39.734
−9.456
1.00
25.52
B
N


ATOM
16375
CA
SER
B
493
50.805
38.298
−9.698
1.00
25.67
B
C


ATOM
16377
CB
SER
B
493
52.214
37.695
−9.775
1.00
25.87
B
C


ATOM
16380
OG
SER
B
493
53.048
38.173
−8.728
1.00
24.83
B
O


ATOM
16382
C
SER
B
493
50.030
37.628
−8.569
1.00
25.46
B
C


ATOM
16383
O
SER
B
493
50.479
37.651
−7.421
1.00
25.26
B
O


ATOM
16385
N
PRO
B
494
48.869
37.023
−8.886
1.00
25.33
B
N


ATOM
16386
CA
PRO
B
494
48.148
36.286
−7.852
1.00
25.35
B
C


ATOM
16388
CB
PRO
B
494
46.819
35.943
−8.526
1.00
25.40
B
C


ATOM
16391
CG
PRO
B
494
47.149
35.847
−9.962
1.00
25.73
B
C


ATOM
16394
CD
PRO
B
494
48.261
36.834
−10.216
1.00
25.52
B
C


ATOM
16397
C
PRO
B
494
48.903
35.017
−7.446
1.00
25.19
B
C


ATOM
16398
O
PRO
B
494
48.708
34.513
−6.337
1.00
25.71
B
O


ATOM
16399
N
PHE
B
495
49.754
34.518
−8.345
1.00
24.45
B
N


ATOM
16400
CA
PHE
B
495
50.663
33.413
−8.048
1.00
23.68
B
C


ATOM
16402
CB
PHE
B
495
50.894
32.569
−9.303
1.00
23.86
B
C


ATOM
16405
CG
PHE
B
495
49.660
31.879
−9.802
1.00
23.56
B
C


ATOM
16406
CD1
PHE
B
495
49.294
30.640
−9.296
1.00
23.17
B
C


ATOM
16408
CE1
PHE
B
495
48.154
29.998
−9.745
1.00
22.12
B
C


ATOM
16410
CZ
PHE
B
495
47.361
30.592
−10.713
1.00
21.69
B
C


ATOM
16412
CE2
PHE
B
495
47.715
31.829
−11.227
1.00
22.40
B
C


ATOM
16414
CD2
PHE
B
495
48.860
32.466
−10.770
1.00
22.45
B
C


ATOM
16416
C
PHE
B
495
52.005
33.919
−7.523
1.00
22.88
B
C


ATOM
16417
O
PHE
B
495
52.295
35.118
−7.564
1.00
22.31
B
O


ATOM
16419
N
ALA
B
496
52.816
32.988
−7.031
1.00
22.48
B
N


ATOM
16420
CA
ALA
B
496
54.155
33.297
−6.542
1.00
22.48
B
C


ATOM
16422
CB
ALA
B
496
54.680
32.144
−5.697
1.00
22.42
B
C


ATOM
16426
C
ALA
B
496
55.093
33.563
−7.716
1.00
22.53
B
C


ATOM
16427
O
ALA
B
496
54.948
32.954
−8.778
1.00
22.92
B
O


ATOM
16429
N
LYS
B
497
56.056
34.463
−7.521
1.00
22.29
B
N


ATOM
16430
CA
LYS
B
497
57.052
34.778
−8.557
1.00
21.94
B
C


ATOM
16432
CB
LYS
B
497
58.007
35.884
−8.084
1.00
22.07
B
C


ATOM
16435
CG
LYS
B
497
57.334
37.237
−7.920
1.00
23.65
B
C


ATOM
16438
CD
LYS
B
497
58.343
38.366
−7.815
1.00
24.78
B
C


ATOM
16441
CE
LYS
B
497
57.645
39.702
−7.616
1.00
25.70
B
C


ATOM
16444
NZ
LYS
B
497
58.598
40.846
−7.649
1.00
26.30
B
N


ATOM
16448
C
LYS
B
497
57.849
33.552
−9.035
1.00
21.17
B
C


ATOM
16449
O
LYS
B
497
58.182
33.465
−10.220
1.00
20.85
B
O


ATOM
16451
N
PRO
B
498
58.169
32.613
−8.120
1.00
20.40
B
N


ATOM
16452
CA
PRO
B
498
58.746
31.335
−8.539
1.00
19.76
B
C


ATOM
16454
CB
PRO
B
498
58.843
30.555
−7.228
1.00
20.02
B
C


ATOM
16457
CG
PRO
B
498
59.067
31.596
−6.208
1.00
20.28
B
C


ATOM
16460
CD
PRO
B
498
58.282
32.797
−6.659
1.00
20.41
B
C


ATOM
16463
C
PRO
B
498
57.892
30.572
−9.551
1.00
19.04
B
C


ATOM
16464
O
PRO
B
498
58.429
30.080
−10.543
1.00
18.97
B
O


ATOM
16465
N
PHE
B
499
56.584
30.478
−9.308
1.00
18.00
B
N


ATOM
16466
CA
PHE
B
499
55.679
29.806
−10.247
1.00
17.28
B
C


ATOM
16468
CB
PHE
B
499
54.339
29.476
−9.595
1.00
17.32
B
C


ATOM
16471
CG
PHE
B
499
53.370
28.806
−10.530
1.00
17.69
B
C


ATOM
16472
CD1
PHE
B
499
53.589
27.497
−10.951
1.00
17.29
B
C


ATOM
16474
CE1
PHE
B
499
52.705
26.871
−11.823
1.00
16.85
B
C


ATOM
16476
CZ
PHE
B
499
51.587
27.557
−12.288
1.00
16.84
B
C


ATOM
16478
CE2
PHE
B
499
51.362
28.868
−11.880
1.00
17.65
B
C


ATOM
16480
CD2
PHE
B
499
52.252
29.486
−11.006
1.00
17.32
B
C


ATOM
16482
C
PHE
B
499
55.432
30.634
−11.505
1.00
16.84
B
C


ATOM
16483
O
PHE
B
499
55.363
30.086
−12.605
1.00
16.87
B
O


ATOM
16485
N
VAL
B
500
55.287
31.947
−11.338
1.00
16.41
B
N


ATOM
16486
CA
VAL
B
500
55.142
32.861
−12.474
1.00
16.20
B
C


ATOM
16488
CB
VAL
B
500
54.925
34.317
−12.010
1.00
16.36
B
C


ATOM
16490
CG1
VAL
B
500
53.606
34.442
−11.264
1.00
17.18
B
C


ATOM
16494
CG2
VAL
B
500
54.957
35.280
−13.191
1.00
16.91
B
C


ATOM
16498
C
VAL
B
500
56.363
32.793
−13.394
1.00
15.82
B
C


ATOM
16499
O
VAL
B
500
56.243
32.992
−14.600
1.00
15.97
B
O


ATOM
16501
N
GLU
B
501
57.531
32.509
−12.822
1.00
15.50
B
N


ATOM
16502
CA
GLU
B
501
58.734
32.258
−13.615
1.00
15.59
B
C


ATOM
16504
CB
GLU
B
501
60.003
32.453
−12.769
1.00
15.69
B
C


ATOM
16507
CG
GLU
B
501
61.332
32.376
−13.545
1.00
15.01
B
C


ATOM
16510
CD
GLU
B
501
61.554
33.531
−14.526
1.00
16.71
B
C


ATOM
16511
OE1
GLU
B
501
60.739
34.482
−14.571
1.00
14.60
B
O


ATOM
16512
OE2
GLU
B
501
62.564
33.485
−15.261
1.00
18.19
B
O


ATOM
16513
C
GLU
B
501
58.704
30.854
−14.231
1.00
15.47
B
C


ATOM
16514
O
GLU
B
501
59.123
30.677
−15.375
1.00
16.14
B
O


ATOM
16516
N
THR
B
502
58.217
29.862
−13.484
1.00
14.76
B
N


ATOM
16517
CA
THR
B
502
58.104
28.497
−14.010
1.00
14.28
B
C


ATOM
16519
CB
THR
B
502
57.531
27.499
−12.973
1.00
14.03
B
C


ATOM
16521
OG1
THR
B
502
58.190
27.660
−11.715
1.00
13.78
B
O


ATOM
16523
CG2
THR
B
502
57.721
26.070
−13.449
1.00
12.78
B
C


ATOM
16527
C
THR
B
502
57.210
28.464
−15.246
1.00
14.49
B
C


ATOM
16528
O
THR
B
502
57.505
27.760
−16.207
1.00
14.67
B
O


ATOM
16530
N
ALA
B
503
56.119
29.227
−15.215
1.00
14.64
B
N


ATOM
16531
CA
ALA
B
503
55.206
29.306
−16.354
1.00
14.82
B
C


ATOM
16533
CB
ALA
B
503
53.932
30.048
−15.973
1.00
14.76
B
C


ATOM
16537
C
ALA
B
503
55.890
29.989
−17.534
1.00
14.83
B
C


ATOM
16538
O
ALA
B
503
55.970
29.425
−18.623
1.00
14.59
B
O


ATOM
16540
N
ILE
B
504
56.404
31.194
−17.307
1.00
14.79
B
N


ATOM
16541
CA
ILE
B
504
57.111
31.936
−18.350
1.00
15.23
B
C


ATOM
16543
CB
ILE
B
504
57.747
33.233
−17.790
1.00
15.36
B
C


ATOM
16545
CG1
ILE
B
504
56.654
34.265
−17.483
1.00
15.16
B
C


ATOM
16548
CD1
ILE
B
504
57.127
35.440
−16.656
1.00
12.30
B
C


ATOM
16552
CG2
ILE
B
504
58.740
33.834
−18.782
1.00
15.13
B
C


ATOM
16556
C
ILE
B
504
58.174
31.065
−19.032
1.00
15.91
B
C


ATOM
16557
O
ILE
B
504
58.417
31.207
−20.231
1.00
16.25
B
O


ATOM
16559
N
ASN
B
505
58.787
30.155
−18.273
1.00
16.36
B
N


ATOM
16560
CA
ASN
B
505
59.760
29.208
−18.829
1.00
16.52
B
C


ATOM
16562
CB
ASN
B
505
60.447
28.408
−17.710
1.00
16.46
B
C


ATOM
16565
CG
ASN
B
505
61.425
29.249
−16.892
1.00
16.04
B
C


ATOM
16566
OD1
ASN
B
505
62.149
30.091
−17.427
1.00
13.66
B
O


ATOM
16567
ND2
ASN
B
505
61.456
29.008
−15.586
1.00
16.62
B
N


ATOM
16570
C
ASN
B
505
59.169
28.251
−19.876
1.00
16.61
B
C


ATOM
16571
O
ASN
B
505
59.891
27.786
−20.761
1.00
16.48
B
O


ATOM
16573
N
LEU
B
506
57.872
27.955
−19.774
1.00
16.86
B
N


ATOM
16574
CA
LEU
B
506
57.171
27.184
−20.810
1.00
17.30
B
C


ATOM
16576
CB
LEU
B
506
55.726
26.888
−20.401
1.00
17.57
B
C


ATOM
16579
CG
LEU
B
506
54.836
26.191
−21.440
1.00
18.47
B
C


ATOM
16581
CD1
LEU
B
506
55.184
24.719
−21.542
1.00
19.77
B
C


ATOM
16585
CD2
LEU
B
506
53.370
26.364
−21.073
1.00
20.68
B
C


ATOM
16589
C
LEU
B
506
57.177
27.946
−22.130
1.00
17.50
B
C


ATOM
16590
O
LEU
B
506
57.340
27.351
−23.195
1.00
17.72
B
O


ATOM
16592
N
ALA
B
507
56.985
29.261
−22.054
1.00
17.77
B
N


ATOM
16593
CA
ALA
B
507
57.067
30.120
−23.233
1.00
17.80
B
C


ATOM
16595
CB
ALA
B
507
56.635
31.536
−22.893
1.00
17.84
B
C


ATOM
16599
C
ALA
B
507
58.483
30.117
−23.796
1.00
17.61
B
C


ATOM
16600
O
ALA
B
507
58.671
29.989
−25.003
1.00
17.76
B
O


ATOM
16602
N
ARG
B
508
59.472
30.246
−22.913
1.00
17.60
B
N


ATOM
16603
CA
ARG
B
508
60.880
30.193
−23.309
1.00
17.71
B
C


ATOM
16605
CB
ARG
B
508
61.803
30.386
−22.100
1.00
17.79
B
C


ATOM
16608
CG
ARG
B
508
61.746
31.773
−21.487
1.00
18.73
B
C


ATOM
16611
CD
ARG
B
508
62.939
32.043
−20.582
1.00
19.55
B
C


ATOM
16614
NE
ARG
B
508
62.905
33.398
−20.024
1.00
19.83
B
N


ATOM
16616
CZ
ARG
B
508
62.358
33.739
−18.857
1.00
19.59
B
C


ATOM
16617
NH1
ARG
B
508
61.781
32.831
−18.073
1.00
19.68
B
N


ATOM
16620
NH2
ARG
B
508
62.391
35.009
−18.468
1.00
19.69
B
N


ATOM
16623
C
ARG
B
508
61.212
28.870
−23.984
1.00
17.74
B
C


ATOM
16624
O
ARG
B
508
61.822
28.855
−25.052
1.00
17.57
B
O


ATOM
16626
N
GLN
B
509
60.806
27.767
−23.355
1.00
17.87
B
N


ATOM
16627
CA
GLN
B
509
61.065
26.428
−23.889
1.00
18.05
B
C


ATOM
16629
CB
GLN
B
509
60.600
25.353
−22.901
1.00
17.84
B
C


ATOM
16632
CG
GLN
B
509
60.772
23.904
−23.383
1.00
17.66
B
C


ATOM
16635
CD
GLN
B
509
62.217
23.521
−23.658
1.00
16.78
B
C


ATOM
16636
OE1
GLN
B
509
63.150
24.156
−23.170
1.00
17.45
B
O


ATOM
16637
NE2
GLN
B
509
62.404
22.471
−24.442
1.00
16.89
B
N


ATOM
16640
C
GLN
B
509
60.396
26.220
−25.248
1.00
18.61
B
C


ATOM
16641
O
GLN
B
509
60.959
25.561
−26.124
1.00
18.92
B
O


ATOM
16643
N
SER
B
510
59.202
26.782
−25.423
1.00
18.83
B
N


ATOM
16644
CA
SER
B
510
58.498
26.692
−26.700
1.00
18.95
B
C


ATOM
16646
CB
SER
B
510
57.109
27.323
−26.603
1.00
18.82
B
C


ATOM
16649
OG
SER
B
510
56.264
26.533
−25.788
1.00
19.00
B
O


ATOM
16651
C
SER
B
510
59.292
27.337
−27.832
1.00
19.16
B
C


ATOM
16652
O
SER
B
510
59.232
26.882
−28.968
1.00
19.43
B
O


ATOM
16654
N
HIS
B
511
60.041
28.390
−27.526
1.00
19.42
B
N


ATOM
16655
CA
HIS
B
511
60.889
29.022
−28.531
1.00
20.02
B
C


ATOM
16657
CB
HIS
B
511
61.405
30.380
−28.041
1.00
20.11
B
C


ATOM
16660
CG
HIS
B
511
60.395
31.479
−28.143
1.00
17.99
B
C


ATOM
16661
ND1
HIS
B
511
60.065
32.074
−29.341
1.00
17.74
B
N


ATOM
16663
CE1
HIS
B
511
59.155
33.006
−29.131
1.00
18.27
B
C


ATOM
16665
NE2
HIS
B
511
58.883
33.038
−27.839
1.00
17.55
B
N


ATOM
16667
CD2
HIS
B
511
59.645
32.092
−27.199
1.00
16.35
B
C


ATOM
16669
C
HIS
B
511
62.058
28.118
−28.933
1.00
20.72
B
C


ATOM
16670
O
HIS
B
511
62.345
27.955
−30.121
1.00
20.84
B
O


ATOM
16672
N
CYS
B
512
62.712
27.519
−27.943
1.00
21.38
B
N


ATOM
16673
CA
CYS
B
512
63.904
26.704
−28.187
1.00
22.20
B
C


ATOM
16675
CB
CYS
B
512
64.715
26.569
−26.894
1.00
22.42
B
C


ATOM
16678
SG
CYS
B
512
65.118
28.158
−26.116
1.00
23.55
B
S


ATOM
16680
C
CYS
B
512
63.604
25.313
−28.765
1.00
22.44
B
C


ATOM
16681
O
CYS
B
512
64.520
24.628
−29.223
1.00
22.16
B
O


ATOM
16683
N
THR
B
513
62.337
24.898
−28.740
1.00
23.12
B
N


ATOM
16684
CA
THR
B
513
61.931
23.599
−29.287
1.00
24.06
B
C


ATOM
16686
CB
THR
B
513
60.899
22.897
−28.371
1.00
24.30
B
C


ATOM
16688
OG1
THR
B
513
61.262
23.083
−26.999
1.00
25.60
B
O


ATOM
16690
CG2
THR
B
513
60.832
21.401
−28.671
1.00
24.35
B
C


ATOM
16694
C
THR
B
513
61.340
23.706
−30.700
1.00
24.58
B
C


ATOM
16695
O
THR
B
513
61.194
22.695
−31.386
1.00
24.46
B
O


ATOM
16697
N
TYR
B
514
61.003
24.921
−31.132
1.00
25.51
B
N


ATOM
16698
CA
TYR
B
514
60.432
25.139
−32.463
1.00
26.21
B
C


ATOM
16700
CB
TYR
B
514
58.968
25.573
−32.348
1.00
25.89
B
C


ATOM
16703
CG
TYR
B
514
58.098
24.497
−31.729
1.00
24.88
B
C


ATOM
16704
CD1
TYR
B
514
57.783
23.342
−32.437
1.00
25.24
B
C


ATOM
16706
CE1
TYR
B
514
56.994
22.346
−31.874
1.00
24.68
B
C


ATOM
16708
CZ
TYR
B
514
56.514
22.499
−30.589
1.00
23.33
B
C


ATOM
16709
OH
TYR
B
514
55.733
21.511
−30.037
1.00
24.82
B
O


ATOM
16711
CE2
TYR
B
514
56.816
23.634
−29.863
1.00
22.23
B
C


ATOM
16713
CD2
TYR
B
514
57.606
24.622
−30.432
1.00
23.14
B
C


ATOM
16715
C
TYR
B
514
61.268
26.142
−33.264
1.00
27.31
B
C


ATOM
16716
O
TYR
B
514
61.143
27.358
−33.107
1.00
27.40
B
O


ATOM
16718
N
HIS
B
515
62.124
25.595
−34.122
1.00
28.61
B
N


ATOM
16719
CA
HIS
B
515
63.102
26.361
−34.893
1.00
30.06
B
C


ATOM
16721
CB
HIS
B
515
64.492
26.228
−34.242
1.00
30.62
B
C


ATOM
16724
CG
HIS
B
515
64.870
24.815
−33.904
1.00
32.08
B
C


ATOM
16725
ND1
HIS
B
515
64.776
24.306
−32.626
1.00
31.97
B
N


ATOM
16727
CE1
HIS
B
515
65.159
23.042
−32.629
1.00
32.68
B
C


ATOM
16729
NE2
HIS
B
515
65.492
22.710
−33.863
1.00
34.16
B
N


ATOM
16731
CD2
HIS
B
515
65.320
23.801
−34.681
1.00
33.51
B
C


ATOM
16733
C
HIS
B
515
63.106
25.831
−36.333
1.00
30.55
B
C


ATOM
16734
O
HIS
B
515
62.201
25.084
−36.717
1.00
30.83
B
O


ATOM
16736
N
ASN
B
516
64.098
26.233
−37.129
1.00
30.79
B
N


ATOM
16737
CA
ASN
B
516
64.294
25.687
−38.474
1.00
30.94
B
C


ATOM
16739
CB
ASN
B
516
63.524
26.513
−39.512
1.00
31.24
B
C


ATOM
16742
CG
ASN
B
516
62.034
26.182
−39.546
1.00
32.16
B
C


ATOM
16743
OD1
ASN
B
516
61.642
25.024
−39.703
1.00
31.94
B
O


ATOM
16744
ND2
ASN
B
516
61.198
27.207
−39.410
1.00
33.17
B
N


ATOM
16747
C
ASN
B
516
65.774
25.639
−38.839
1.00
30.76
B
C


ATOM
16748
O
ASN
B
516
66.617
25.303
−38.007
1.00
30.70
B
O


ATOM
16750
N
THR
B
521
72.475
22.115
−40.233
1.00
39.09
B
N


ATOM
16751
CA
THR
B
521
71.640
21.708
−39.109
1.00
39.22
B
C


ATOM
16753
CB
THR
B
521
71.978
22.514
−37.832
1.00
39.15
B
C


ATOM
16755
OG1
THR
B
521
73.375
22.401
−37.542
1.00
39.43
B
O


ATOM
16757
CG2
THR
B
521
71.181
22.001
−36.647
1.00
38.86
B
C


ATOM
16761
C
THR
B
521
70.152
21.875
−39.426
1.00
39.42
B
C


ATOM
16762
O
THR
B
521
69.595
22.965
−39.281
1.00
39.63
B
O


ATOM
16764
N
SER
B
522
69.519
20.787
−39.860
1.00
39.51
B
N


ATOM
16765
CA
SER
B
522
68.067
20.756
−40.065
1.00
39.64
B
C


ATOM
16767
CB
SER
B
522
67.675
19.512
−40.881
1.00
39.62
B
C


ATOM
16770
OG
SER
B
522
68.247
18.334
−40.340
1.00
39.80
B
O


ATOM
16772
C
SER
B
522
67.354
20.780
−38.702
1.00
39.74
B
C


ATOM
16773
O
SER
B
522
68.014
20.665
−37.666
1.00
39.55
B
O


ATOM
16775
N
PRO
B
523
66.013
20.952
−38.691
1.00
40.10
B
N


ATOM
16776
CA
PRO
B
523
65.277
20.965
−37.414
1.00
40.09
B
C


ATOM
16778
CB
PRO
B
523
63.811
21.075
−37.849
1.00
40.16
B
C


ATOM
16781
CG
PRO
B
523
63.856
21.703
−39.192
1.00
40.42
B
C


ATOM
16784
CD
PRO
B
523
65.125
21.234
−39.836
1.00
40.33
B
C


ATOM
16787
C
PRO
B
523
65.498
19.703
−36.572
1.00
40.04
B
C


ATOM
16788
O
PRO
B
523
65.670
19.800
−35.353
1.00
39.93
B
O


ATOM
16789
N
ASP
B
524
65.479
18.538
−37.222
1.00
39.90
B
N


ATOM
16790
CA
ASP
B
524
65.886
17.277
−36.593
1.00
39.64
B
C


ATOM
16792
CB
ASP
B
524
65.136
16.081
−37.198
1.00
39.95
B
C


ATOM
16795
CG
ASP
B
524
63.726
15.926
−36.655
1.00
40.66
B
C


ATOM
16796
OD1
ASP
B
524
63.491
16.229
−35.465
1.00
40.38
B
O


ATOM
16797
OD2
ASP
B
524
62.851
15.477
−37.425
1.00
42.77
B
O


ATOM
16798
C
ASP
B
524
67.386
17.083
−36.782
1.00
38.91
B
C


ATOM
16799
O
ASP
B
524
67.812
16.471
−37.759
1.00
39.00
B
O


ATOM
16801
N
GLU
B
525
68.159
17.608
−35.830
1.00
38.15
B
N


ATOM
16802
CA
GLU
B
525
69.642
17.592
−35.810
1.00
37.66
B
C


ATOM
16804
CB
GLU
B
525
70.297
17.569
−37.206
1.00
37.71
B
C


ATOM
16807
CG
GLU
B
525
70.620
16.153
−37.724
1.00
37.79
B
C


ATOM
16810
CD
GLU
B
525
71.981
16.048
−38.386
1.00
38.25
B
C


ATOM
16811
OE1
GLU
B
525
72.955
16.625
−37.857
1.00
39.00
B
O


ATOM
16812
OE2
GLU
B
525
72.080
15.370
−39.430
1.00
38.77
B
O


ATOM
16813
C
GLU
B
525
70.191
18.771
−34.994
1.00
36.95
B
C


ATOM
16814
O
GLU
B
525
71.317
18.714
−34.499
1.00
37.04
B
O


ATOM
16816
N
LEU
B
526
69.407
19.842
−34.880
1.00
36.09
B
N


ATOM
16817
CA
LEU
B
526
69.625
20.840
−33.837
1.00
35.33
B
C


ATOM
16819
CB
LEU
B
526
68.900
22.150
−34.161
1.00
35.12
B
C


ATOM
16822
CG
LEU
B
526
69.334
23.384
−33.364
1.00
34.90
B
C


ATOM
16824
CD1
LEU
B
526
68.442
24.568
−33.694
1.00
34.94
B
C


ATOM
16828
CD2
LEU
B
526
70.793
23.730
−33.630
1.00
36.14
B
C


ATOM
16832
C
LEU
B
526
69.105
20.252
−32.527
1.00
34.83
B
C


ATOM
16833
O
LEU
B
526
69.770
20.327
−31.496
1.00
34.87
B
O


ATOM
16835
N
THR
B
527
67.913
19.660
−32.586
1.00
34.52
B
N


ATOM
16836
CA
THR
B
527
67.303
18.996
−31.434
1.00
34.28
B
C


ATOM
16838
CB
THR
B
527
65.908
18.433
−31.788
1.00
34.07
B
C


ATOM
16840
OG1
THR
B
527
65.038
19.509
−32.164
1.00
33.57
B
O


ATOM
16842
CG2
THR
B
527
65.306
17.682
−30.606
1.00
33.37
B
C


ATOM
16846
C
THR
B
527
68.179
17.857
−30.916
1.00
34.29
B
C


ATOM
16847
O
THR
B
527
68.451
17.771
−29.716
1.00
34.38
B
O


ATOM
16849
N
ARG
B
528
68.617
16.992
−31.829
1.00
34.09
B
N


ATOM
16850
CA
ARG
B
528
69.465
15.850
−31.485
1.00
34.07
B
C


ATOM
16852
CB
ARG
B
528
69.933
15.138
−32.760
1.00
34.30
B
C


ATOM
16855
CG
ARG
B
528
70.746
13.869
−32.528
1.00
35.25
B
C


ATOM
16858
CD
ARG
B
528
71.215
13.264
−33.849
1.00
36.66
B
C


ATOM
16861
NE
ARG
B
528
72.244
14.073
−34.513
1.00
37.15
B
N


ATOM
16863
CZ
ARG
B
528
73.534
14.113
−34.169
1.00
36.44
B
C


ATOM
16864
NH1
ARG
B
528
73.996
13.397
−33.146
1.00
35.92
B
N


ATOM
16867
NH2
ARG
B
528
74.373
14.884
−34.854
1.00
35.81
B
N


ATOM
16870
C
ARG
B
528
70.673
16.287
−30.655
1.00
33.89
B
C


ATOM
16871
O
ARG
B
528
70.950
15.705
−29.606
1.00
34.34
B
O


ATOM
16873
N
LYS
B
529
71.378
17.313
−31.127
1.00
33.28
B
N


ATOM
16874
CA
LYS
B
529
72.566
17.824
−30.436
1.00
32.69
B
C


ATOM
16876
CB
LYS
B
529
73.298
18.863
−31.294
1.00
32.75
B
C


ATOM
16879
CG
LYS
B
529
74.085
18.275
−32.452
1.00
32.66
B
C


ATOM
16882
CD
LYS
B
529
74.956
19.327
−33.120
1.00
32.31
B
C


ATOM
16885
CE
LYS
B
529
75.829
18.711
−34.200
1.00
32.91
B
C


ATOM
16888
NZ
LYS
B
529
76.857
19.660
−34.708
1.00
33.59
B
N


ATOM
16892
C
LYS
B
529
72.225
18.436
−29.079
1.00
32.13
B
C


ATOM
16893
O
LYS
B
529
72.916
18.182
−28.091
1.00
32.37
B
O


ATOM
16895
N
ARG
B
530
71.165
19.241
−29.037
1.00
31.27
B
N


ATOM
16896
CA
ARG
B
530
70.759
19.913
−27.800
1.00
30.74
B
C


ATOM
16898
CB
ARG
B
530
69.629
20.912
−28.070
1.00
30.66
B
C


ATOM
16901
CG
ARG
B
530
70.095
22.182
−28.768
1.00
30.10
B
C


ATOM
16904
CD
ARG
B
530
68.926
23.081
−29.131
1.00
28.52
B
C


ATOM
16907
NE
ARG
B
530
69.370
24.383
−29.626
1.00
26.96
B
N


ATOM
16909
CZ
ARG
B
530
68.554
25.374
−29.982
1.00
26.60
B
C


ATOM
16910
NH1
ARG
B
530
67.234
25.224
−29.904
1.00
26.51
B
N


ATOM
16913
NH2
ARG
B
530
69.059
26.524
−30.420
1.00
26.25
B
N


ATOM
16916
C
ARG
B
530
70.346
18.918
−26.716
1.00
30.41
B
C


ATOM
16917
O
ARG
B
530
70.684
19.097
−25.546
1.00
30.43
B
O


ATOM
16919
N
VAL
B
531
69.626
17.871
−27.110
1.00
30.03
B
N


ATOM
16920
CA
VAL
B
531
69.278
16.784
−26.191
1.00
29.78
B
C


ATOM
16922
CB
VAL
B
531
68.275
15.782
−26.834
1.00
30.01
B
C


ATOM
16924
CG1
VAL
B
531
68.603
14.335
−26.458
1.00
30.16
B
C


ATOM
16928
CG2
VAL
B
531
66.841
16.141
−26.447
1.00
29.98
B
C


ATOM
16932
C
VAL
B
531
70.530
16.052
−25.694
1.00
29.45
B
C


ATOM
16933
O
VAL
B
531
70.578
15.616
−24.543
1.00
29.37
B
O


ATOM
16935
N
LEU
B
532
71.536
15.927
−26.559
1.00
29.15
B
N


ATOM
16936
CA
LEU
B
532
72.822
15.331
−26.167
1.00
28.66
B
C


ATOM
16938
CB
LEU
B
532
73.687
14.993
−27.391
1.00
28.54
B
C


ATOM
16941
CG
LEU
B
532
73.627
13.537
−27.858
1.00
29.13
B
C


ATOM
16943
CD1
LEU
B
532
72.216
13.153
−28.293
1.00
29.00
B
C


ATOM
16947
CD2
LEU
B
532
74.630
13.293
−28.983
1.00
29.97
B
C


ATOM
16951
C
LEU
B
532
73.602
16.232
−25.208
1.00
28.00
B
C


ATOM
16952
O
LEU
B
532
74.158
15.751
−24.220
1.00
28.07
B
O


ATOM
16954
N
SER
B
533
73.632
17.532
−25.500
1.00
26.92
B
N


ATOM
16955
CA
SER
B
533
74.369
18.495
−24.679
1.00
26.09
B
C


ATOM
16957
CB
SER
B
533
74.469
19.844
−25.392
1.00
26.14
B
C


ATOM
16960
OG
SER
B
533
73.243
20.553
−25.320
1.00
26.63
B
O


ATOM
16962
C
SER
B
533
73.722
18.697
−23.311
1.00
25.29
B
C


ATOM
16963
O
SER
B
533
74.420
18.822
−22.303
1.00
25.77
B
O


ATOM
16965
N
VAL
B
534
72.392
18.729
−23.284
1.00
24.07
B
N


ATOM
16966
CA
VAL
B
534
71.643
19.035
−22.065
1.00
23.05
B
C


ATOM
16968
CB
VAL
B
534
70.265
19.652
−22.401
1.00
22.97
B
C


ATOM
16970
CG1
VAL
B
534
69.412
19.793
−21.152
1.00
23.85
B
C


ATOM
16974
CG2
VAL
B
534
70.448
21.003
−23.069
1.00
21.88
B
C


ATOM
16978
C
VAL
B
534
71.462
17.820
−21.153
1.00
22.17
B
C


ATOM
16979
O
VAL
B
534
71.657
17.926
−19.942
1.00
21.94
B
O


ATOM
16981
N
ILE
B
535
71.098
16.674
−21.728
1.00
21.59
B
N


ATOM
16982
CA
ILE
B
535
70.783
15.471
−20.938
1.00
20.91
B
C


ATOM
16984
CB
ILE
B
535
69.589
14.673
−21.539
1.00
20.66
B
C


ATOM
16986
CG1
ILE
B
535
68.343
15.558
−21.675
1.00
19.60
B
C


ATOM
16989
CD1
ILE
B
535
67.826
16.119
−20.364
1.00
17.67
B
C


ATOM
16993
CG2
ILE
B
535
69.271
13.457
−20.680
1.00
19.45
B
C


ATOM
16997
C
ILE
B
535
71.972
14.519
−20.762
1.00
20.28
B
C


ATOM
16998
O
ILE
B
535
72.342
14.203
−19.633
1.00
19.52
B
O


ATOM
17000
N
THR
B
536
72.561
14.061
−21.866
1.00
20.21
B
N


ATOM
17001
CA
THR
B
536
73.580
13.003
−21.806
1.00
20.57
B
C


ATOM
17003
CB
THR
B
536
73.444
12.009
−22.988
1.00
20.61
B
C


ATOM
17005
OG1
THR
B
536
73.670
12.688
−24.229
1.00
21.12
B
O


ATOM
17007
CG2
THR
B
536
72.058
11.372
−22.996
1.00
20.40
B
C


ATOM
17011
C
THR
B
536
75.025
13.520
−21.730
1.00
20.49
B
C


ATOM
17012
O
THR
B
536
75.658
13.438
−20.677
1.00
20.27
B
O


ATOM
17014
N
GLU
B
537
75.541
14.045
−22.838
1.00
20.64
B
N


ATOM
17015
CA
GLU
B
537
76.956
14.423
−22.932
1.00
21.04
B
C


ATOM
17017
CB
GLU
B
537
77.330
14.745
−24.384
1.00
21.51
B
C


ATOM
17020
CG
GLU
B
537
77.292
13.537
−25.324
1.00
22.54
B
C


ATOM
17023
CD
GLU
B
537
77.568
13.898
−26.780
1.00
23.27
B
C


ATOM
17024
OE1
GLU
B
537
78.095
13.035
−27.516
1.00
21.98
B
O


ATOM
17025
OE2
GLU
B
537
77.257
15.038
−27.189
1.00
24.15
B
O


ATOM
17026
C
GLU
B
537
77.311
15.617
−22.031
1.00
20.83
B
C


ATOM
17027
O
GLU
B
537
76.737
16.700
−22.187
1.00
20.87
B
O


ATOM
17029
N
PRO
B
538
78.272
15.433
−21.099
1.00
20.36
B
N


ATOM
17030
CA
PRO
B
538
78.649
16.551
−20.233
1.00
19.96
B
C


ATOM
17032
CB
PRO
B
538
79.456
15.883
−19.104
1.00
19.93
B
C


ATOM
17035
CG
PRO
B
538
79.623
14.441
−19.482
1.00
19.71
B
C


ATOM
17038
CD
PRO
B
538
79.135
14.258
−20.878
1.00
20.30
B
C


ATOM
17041
C
PRO
B
538
79.501
17.592
−20.943
1.00
19.59
B
C


ATOM
17042
O
PRO
B
538
79.934
17.380
−22.077
1.00
19.30
B
O


ATOM
17043
N
ILE
B
539
79.728
18.715
−20.272
1.00
19.52
B
N


ATOM
17044
CA
ILE
B
539
80.663
19.715
−20.763
1.00
20.00
B
C


ATOM
17046
CB
ILE
B
539
80.524
21.056
−20.008
1.00
20.22
B
C


ATOM
17048
CG1
ILE
B
539
79.134
21.656
−20.230
1.00
19.71
B
C


ATOM
17051
CD1
ILE
B
539
78.919
22.967
−19.510
1.00
19.23
B
C


ATOM
17055
CG2
ILE
B
539
81.594
22.051
−20.464
1.00
19.98
B
C


ATOM
17059
C
ILE
B
539
82.072
19.168
−20.569
1.00
20.32
B
C


ATOM
17060
O
ILE
B
539
82.372
18.577
−19.530
1.00
20.46
B
O


ATOM
17062
N
LEU
B
540
82.928
19.353
−21.569
1.00
20.70
B
N


ATOM
17063
CA
LEU
B
540
84.317
18.904
−21.480
1.00
21.15
B
C


ATOM
17065
CB
LEU
B
540
85.103
19.328
−22.725
1.00
21.14
B
C


ATOM
17068
CG
LEU
B
540
84.665
18.725
−24.065
1.00
20.69
B
C


ATOM
17070
CD1
LEU
B
540
85.271
19.506
−25.229
1.00
19.34
B
C


ATOM
17074
CD2
LEU
B
540
85.032
17.246
−24.140
1.00
17.98
B
C


ATOM
17078
C
LEU
B
540
84.957
19.510
−20.230
1.00
21.63
B
C


ATOM
17079
O
LEU
B
540
84.734
20.687
−19.939
1.00
22.38
B
O


ATOM
17081
N
PRO
B
541
85.746
18.716
−19.481
1.00
21.69
B
N


ATOM
17082
CA
PRO
B
541
86.321
19.215
−18.224
1.00
21.85
B
C


ATOM
17084
CB
PRO
B
541
87.149
18.027
−17.712
1.00
21.79
B
C


ATOM
17087
CG
PRO
B
541
87.361
17.154
−18.895
1.00
22.13
B
C


ATOM
17090
CD
PRO
B
541
86.153
17.327
−19.754
1.00
21.68
B
C


ATOM
17093
C
PRO
B
541
87.205
20.452
−18.389
1.00
22.14
B
C


ATOM
17094
O
PRO
B
541
87.704
20.723
−19.480
1.00
22.12
B
O


ATOM
17095
N
PHE
B
542
87.385
21.191
−17.298
1.00
22.72
B
N


ATOM
17096
CA
PHE
B
542
88.184
22.414
−17.305
1.00
23.32
B
C


ATOM
17098
CB
PHE
B
542
87.783
23.298
−16.120
1.00
23.32
B
C


ATOM
17101
CG
PHE
B
542
88.756
24.402
−15.833
1.00
24.16
B
C


ATOM
17102
CD1
PHE
B
542
89.494
24.409
−14.654
1.00
24.68
B
C


ATOM
17104
CE1
PHE
B
542
90.398
25.425
−14.389
1.00
24.06
B
C


ATOM
17106
CZ
PHE
B
542
90.580
26.443
−15.309
1.00
24.14
B
C


ATOM
17108
CE2
PHE
B
542
89.853
26.444
−16.491
1.00
24.52
B
C


ATOM
17110
CD2
PHE
B
542
88.949
25.426
−16.748
1.00
24.49
B
C


ATOM
17112
C
PHE
B
542
89.688
22.104
−17.261
1.00
23.94
B
C


ATOM
17113
O
PHE
B
542
90.167
21.469
−16.320
1.00
23.65
B
O


ATOM
17115
N
GLU
B
543
90.421
22.563
−18.279
1.00
24.84
B
N


ATOM
17116
CA
GLU
B
543
91.874
22.344
−18.380
1.00
25.76
B
C


ATOM
17118
CB
GLU
B
543
92.235
21.696
−19.728
1.00
25.79
B
C


ATOM
17121
CG
GLU
B
543
92.464
20.182
−19.672
1.00
25.69
B
C


ATOM
17124
CD
GLU
B
543
93.330
19.661
−20.818
1.00
25.14
B
C


ATOM
17125
OE1
GLU
B
543
93.398
20.313
−21.883
1.00
24.79
B
O


ATOM
17126
OE2
GLU
B
543
93.945
18.587
−20.650
1.00
23.90
B
O


ATOM
17127
C
GLU
B
543
92.683
23.634
−18.213
1.00
26.66
B
C


ATOM
17128
O
GLU
B
543
92.137
24.738
−18.259
1.00
26.93
B
O


ATOM
17130
N
ARG
B
544
93.992
23.470
−18.017
1.00
27.44
B
N


ATOM
17131
CA
ARG
B
544
94.937
24.585
−17.945
1.00
28.02
B
C


ATOM
17133
CB
ARG
B
544
95.430
24.787
−16.509
1.00
28.24
B
C


ATOM
17136
CG
ARG
B
544
94.332
25.114
−15.508
1.00
29.37
B
C


ATOM
17139
CD
ARG
B
544
94.881
25.278
−14.094
1.00
31.23
B
C


ATOM
17142
NE
ARG
B
544
93.858
25.011
−13.080
1.00
33.21
B
N


ATOM
17144
CZ
ARG
B
544
93.577
23.811
−12.563
1.00
34.35
B
C


ATOM
17145
NH1
ARG
B
544
94.242
22.720
−12.943
1.00
34.25
B
N


ATOM
17148
NH2
ARG
B
544
92.616
23.700
−11.649
1.00
34.18
B
N


ATOM
17151
C
ARG
B
544
96.124
24.303
−18.862
1.00
28.26
B
C


ATOM
17152
O
ARG
B
544
96.881
25.207
−19.220
1.00
28.64
B
O


ATOM
17154
O
HOH
C
1
49.400
−35.729
6.838
1.00
2.00

O


ATOM
17157
O
HOH
C
2
77.843
−36.939
−9.130
1.00
2.00

O


ATOM
17160
O
HOH
C
3
55.726
−22.590
−6.230
1.00
19.51

O


ATOM
17163
O
HOH
C
4
37.476
−22.187
−17.999
1.00
2.00

O









Example 9
Expression and Purification of IspS-T536F
Expression of 6×His-Tagged IspS-T536F
N-terminally 6×His-tagged IspS-T536F was expressed and purified from strain DW363. The growth procedure is suitable for histidine tagged enzymes expressed in BL21(λDE3)pLysS cells. A 10 ml overnight culture was prepared for each 1 L of planned growth. The appropriate antibiotics (50 mg/ml kanamycin, 50 mg/ml chloramphenicol) were added to 10 ml of LB medium in a 25 ml flask which was inoculated with 1 colony from a fresh plate of cells or directly from glycerol frozen cell stock. Cultures were grown at 30° C. overnight with shaking at  ̃220 rpm. Day cultures were prepared in 1 liter of LB medium with appropriate antibiotics for each culture. Each 1 L day culture was inoculated with 10 ml of overnight culture and grown at 30-37° C. with shaking at  ̃220 rpm until the OD600 reached  ̃0.4-0.6. Day cultures were then induced with 400 μM IPTG and allowed to continue growing at 30° C. with shaking at 220 rpm for  ̃5-6 hours. Cells were then harvested by centrifugation at 10,000×g for 10 min, 4° C. Following Harvest, cells were used directly or stored at −80° C. until ready to process.
Purification of 6×His-Tagged IspS-T536F
For purification of histidine tagged enzymes from BL21(λDE3)pLysS cells, cells were gently resuspended in fresh Lysis buffer (Lysis buffer: Ni wash buffer+0.5 mM PMST, 0.01% Tween-20, 1 mg/ml lysozyme, 0.2 mg/ml DNaseI; Ni wash buffer: 50 mM NaH2PO4, 300 mM NaCl, 20 mM Imidazole, pH 8.0). Approximately 40-50 ml of lysis buffer was used per 1 L of cell pellet. Cells were then incubated on ice for approximately 30 min. The cell suspension was then lysed fully by passing 2-3 times through a french pressure cell (large french press cell at 1200 psi/High setting) until lysate started to look clear. A sample of the lysate was saved for activity assay and gel analysis ( ̃100 μl). The lysate was then clarified by centrifuging the lysate at 30,000×g for 30 min, 4° C. in a Sorvall Discovery 90SE ultracentrifuge. The supernatant was removed and retained. A sample of the “clarified lysate” was saved for activity assay and gel analysis ( ̃100 μl).
The clarified lysate was run over HisTrap HP columns (GE healthcare) using a gradient from 0-100% Ni buffer B. Following loading of the lysate on the column, the column was washed with Ni wash buffer (50 mM NaH2PO4, 300 mm NaCl, 20 mM imidazole, ph 8.0). The his-tagged IspS was then eluted from the column using a gradient from 0-100% Ni elution buffer (50 mM NaH2PO4, 300 mM NaCl, 500 mM imidazole, ph 8.0) and fractions containing the his-tagged IspS were collected. The column was then washed with Ni stripping buffer (20 mM NaH2PO4, 0.5 m NaCl, 50 mM EDTA, ph 7.4). Samples were then analyzed by SDS-PAGE gel (4-12% gel NUPAGE, Invitrogen) according to manufacturer's directions. Desired fractions were concentrated on spin filters (Vivaspin-20, Sartoris,) and then desalted over a Hi Prep 26/10 Desalting column (GE healthcare) packed with Sephadex G25 resin. The G-25 buffer consisted of 50 mM HEPES, 50 mM NaCl, and 1 mM DTT, pH 7.4. Fractions were then analyzed and concentrated. The samples were then stored at −80° C.
TEV Cleavage (IspS-T536F from Strains DW363)
Strain DW363 is described in Example 6. Digestion was performed with TurboTEV Protease from Eton Bioscience Inc. One unit of TurboTEV per 10 μg of purified protein was used. The digest was performed at 4° C. overnight. Samples were passed through another Ni column equilibrated in the Ni buffer to remove uncleaved enzyme, tag, TurboTEV protease (which is also tagged), and impurities. The Ni column pass though and washes were analyzed using SDS-PAGE gel (NUPAGE, Invitrogen; FIG. 54) and DMAPP activity assays. Samples containing pure enzyme were pooled and desalted into 50 mM NaCl pH 7.4 buffer containing 1 mM DTT and stored at −80° C.
Expression Levels of IspS Variants
Small Scale Expression of 6×His-Tagged IspS Variants
N-terminally 6×His-tagged wild type IspS, IspS-L494P, and IspS-T536F were expressed and purified from strains MD09-167, DW399, and DW363, respectively. The growth procedure is suitable for histidine tagged enzymes expressed in BL21(λDE3)pLysS cells. A 3 ml of overnight culture was prepared for each 100 mL of planned growth. The appropriate antibiotics (50 mg/ml kanamycin, 25 mg/ml chloramphenicol) were added to 3 ml of LB medium in a 10 ml glass tube and was inoculated with 1 colony from a fresh plate of cells or directly from glycerol frozen cell stock. Cultures were grown at 30° C. overnight with shaking at  ̃220 rpm. Day cultures were prepared in 100 mL of LB medium with appropriate antibiotics for each culture. Each 100 mL day culture was inoculated with 50 μl of overnight culture and grown at 37° C. with shaking at  ̃220 rpm until the OD600 reached  ̃0.4-0.6. Day cultures were then induced with 400 μM IPTG and allowed to continue growing at 30° C. with shaking at 220 rpm for  ̃5-6 hours. Cells were then harvested by centrifugation at 10,000×g for 10 min, 4° C. Following Harvest, cells were used directly or stored at −80° C. until ready to process.
Purification of 6×His-Tagged IspS Variants Expressed in Small Scale
For purification of histidine tagged enzymes from BL21(λDE3)pLysS cells, cells were gently resuspended in fresh Lysis buffer (Lysis buffer: Ni wash buffer+0.5 mM PMST, 0.01% Tween-20, 1 mg/ml lysozyme, 0.2 mg/ml DNaseI; Ni wash buffer: 50 mM NaH2PO4, 300 mM NaCl, 20 mM Imidazole, pH 8.0). Approximately 3 ml of lysis buffer was used per 5 mL of cell pellet. Cells were then incubated on ice for approximately 30 min. The cell suspension was then lysed fully by passing 2-3 times through a french pressure cell (small french press cell at 850 psi/Low setting) until lysate started to look clear. A sample of the lysate was saved for activity assay and gel analysis ( ̃100 μl). The lysate was then clarified by centrifuging the lysate at 30,000×g for 30 min, 4° C. in a Sorvall Discovery 90SE ultracentrifuge. The supernatant was removed and retained. A sample of the “clarified lysate” was saved for activity assay and gel analysis ( ̃100 μl).
A 20 mL disposable column containing 0.5 mL Ni Sepharose 6 Fast Flow resin (Amersham) was pre equilibrated with 10 mL of Ni wash buffer. Protein in the clarified lysate was added to the column and shaken gently for 60 min at 4° C. in order to bind the tagged protein. The protein was then eluted with 2.5 mL Ni elution buffer. A sample of the eluate was saved for activity assay and gel analysis ( ̃100 μl).
To buffer exchange the protein into a buffer suitable for protein assays and storage, a PD-10 column (GE Healthcare) was equilibrated with 25 mL PD-10 buffer (50 mM HEPES, 0.05 M NaCl, pH 7.4). Protein was loaded onto the PD-10 column and eluted with 3.5 mL of PD-10 buffer. The eluate was then analyzed by absorbance at 280 nm and SDS-PAGE gel and the samples were stored at −80° C.
Analysis of the yield of purified wild type IspS compared to IspS-L494P, and IspS-T536F suggests that both IspS-L494P and IspS-T536F are expressed at higher levels than the wild type protein (Table 9, FIG. 55).
Differential Scanning Calorimetry
Excessive heat capacity curves were measured using an ultrasensitive scanning high-throughput microcalorimeter, VP-Cap DSC (MicroCal, Inc., Northampton, Mass.). The standard procedure for Differential Scanning calorimetry (DSC) measurements and the theory of the technique is previously published (Freire, E. (1995) Differential Scanning calorimetry Methods. Mol. Biol. 41, 191-218). Approximately 500 μL of 0.5 mg/ml IspS (from strain MD09-167) or variant IspS-L494P (from strain DW399) and IspS-T536F (from strain DW363) (in the absence or presence of 5 mM sodium pyrophosphate) were scanned over a 30-100° C. temperature range. The same sample was then re-scanned to check the reversibility of the process. For IspS the thermal unfolding process was irreversible. The buffer used was 50 mM HEPES, 5 mM MgCl2, pH 7.4, with and without 5 mM sodium pyrophosphate. Sodium pyrophosphate was included for its ability to function as a substrate analog. A 200° C./hr scan rate was used to minimize any artifacts that may result from aggregation. The thermal midpoint (Tm) of the DSC curves was used as an indicator of the thermal stability. The thermal melting curves and the melting points for the wild type IspS and variants are shown in FIGS. 56 (buffer only) and 57 (with 5 mM sodium pyrophosphate).
The thermal unfolding for the IspS variants IspS-L494P and IspS-T536F in buffer demonstrates a considerable increase in the melting points for the variants when compared to that for the wild type. In buffer alone, the wild type IspS has a thermal melting point of 58.3° C. while the Tm's for IspS-L494P and IspS-T536F are 60.4° C. and 62.1° C., respectively. Thus, the substitution of L494 with P results in an increase in the Tm of 2.1° C., and the substitution of T536 with F results in an increase in the Tm of 3.8° C.
In the presence of sodium pyrophosphate, the wild type IspS and IspS variants all exhibit a decrease in melting point compared to analysis in buffer alone. When wild type IspS and the variants were thermally-unfolded in the presence of 5 mM sodium pyrophosphate, wild type IspS has a thermal melting point of 54.7° C., while the Tm's for IspS-L494P and IspS-T536F are 57.0° C. and 59.4° C., respectively. Thus, the substitution of L494 with P results in an increase in the Tm of 2.3° C., and the substitution of T536 with F results in an increase in the Tm of 4.7° C. The change in the shape of the DSC traces in the presence of substrate analog and the decrease in the Tm for the proteins could be the result of aggregation or represent a structure or conformational change of the protein upon complexation of the substrate analog. In addition, there is an exothermic peak. Nonetheless, the changes in the Tm's are fairly consistent with those for buffer alone.
Isoprene Synthase Activity vs Temperature
The activity of wild type IspS and variants IspS-L494P and IspS-T536F was measured across a spectrum of temperatures. Individual DMAPP assays were performed at 5° C. intervals from 25° C. to 80° C. by incubating the vials in a pre-heated water bath.
Isoprene Synthase DMAPP Assay
The following reaction mixture was used for the DMAPP assay: 25 μL purified protein, 5 μL MgCl2 (1 M), 5 μL DMAPP (100 mM), and 65 μL 100 mM Tris pH 8, 100 mM NaCl for a total volume of 100 μL. The reaction is performed at the specified temperature for 15 minutes in a gas tight 1.8 mL GC tube. Reactions are terminated by the addition of 100 μL 500 mM EDTA (pH 8). The amount of isoprene produced was measured by GC/MS.
The analysis was performed using an Agilent 6890 GC/MS system interfaced with a CTC Analytics CombiPAL autosampler operating in headspace mode. An Agilent HP-5MS GC/MS column (30 m×0.25 mm; 0.25 μm film thickness) was used for separation of analytes. The sampler was set up to inject 500 μL of headspace gas. The GC/MS method utilized helium as the carrier gas at a flow of 1 ml/min. The injection port was held at 250° C. with a split ratio of 50:1. The oven temperature was held at 37° C. for the 2 min duration of the analysis. The Agilent 5793N mass selective detector was run in single ion monitoring (SIM) mode on m/z 67. The detector was switched off from 1.4 to 1.7 minutes to allow the elution of permanent gases. Under these conditions isoprene (2-methyl-1,3-butadiene) was observed to elute at 1.78 minutes. A calibration table was used to quantify the absolute amount of isoprene and was found to be linear from 1 μg/L to 200 μg/L. The limit of detection was estimated to be 50-100 ng/L using this method.
The temperature activity ratios for wild type IspS and variants IspS-L494P and IspS-T536F are plotted in FIG. 58. The IspS-T536F variant shifts the curve both upwards and to the right, suggesting that it has increased activity and thermostability as compared to wild type IspS and IspS-L494P. The activity and thermostability benefits of the T536F variant may be attributable to the replacement of a polar amino acid residue (threonine) with a large, hydrophobic residue (phenylalanine). FIG. 59 shows that at the 536 position, hydrophobic residues such as isoleucine, valine, and phenylalanine are common to many terpene synthase enzymes. It is therefore possible that the T536F mutation serves to remove polarity and introduce a more hydrophobic local region, and this change leads to the observed benefits in catalytic efficiency.







TABLE 9







Relative yield of purified IspS-L494P and


IspS-T536F compared to wild type IspS










Protein
Relative Yield














Wild type IspS
1



IspS-L494P
1.3



IspS-T536F
1.9

## Claims

1. An isolated host cell comprising an isoprene synthase variant produced by:
a) identifying hydrophobic amino acid residues on the surface of isoprene synthase based on the three dimensional structure of P. alba isoprene synthase;
b) introducing one or more amino acid substitutions in the surface amino acids of said isoprene synthase to produce an isoprene synthase variant; and
c) identifying said isoprene synthase variants with substitutions that improve activity, expression or stability of the isoprene synthase,
wherein said isoprene synthase variant comprises one or more amino acid substitutions at a hydrophobic surface amino acid position corresponding to a hydrophobic surface amino acid position of SEQ ID NO: 45 selected from the group I28, V30, L130, G153, L469, L303 and L494; and
wherein said isoprene synthase variant has improved activity, expression or stability of the isoprene synthase compared to an isoprene synthase without said one or more amino acid substitutions.

2. An isolated host cell comprising an isoprene synthase variant, wherein the isoprene synthase variant comprises one or more amino acid substitutions at a hydrophobic surface amino acid position corresponding to a hydrophobic surface amino acid position of SEQ ID NO: 45 selected from the group I28, V30, L130, G153, L469, L303 and L494 and wherein said isoprene synthase variant has improved activity, expression and/or stability as compared to an isoprene synthase without said one or more amino acid substitutions.

3. The isolated host cell of claim 2 wherein the variant comprises one or more substitutions selected from the group consisting of: I28W, I28T, I28R, I28Y, V30K, L130W, L130K, L130S, L130Y, L130R, L130V, L130I, L130E, L130D, G153K, G153H, G153L, G153W, L303I, L469A, L469Q, L494P, L494C, L494I, L494V, L494S, L494G, and L494D.

4. The isolated host cell of claim 2, wherein the cell is a gram-positive bacterial cell, gram-negative bacterial cell, filamentous fungal cell, or yeast cell.

5. The isolated host cell of claim 4, wherein the bacterial cell is selected from the group consisting of E. coli, P. citrea, B. subtilis, B. licheniformis, B. lentus, B. brevis, B. stearothermophilus, B. alkalophilus, B. amyloliquefaciens, B. clausii, B. halodurans, B. megaterium, B. coagulans, B. circulans, B. lautus, B. thuringiensis, S. albus, S. lividans, S. coelicolor, S. griseus, Pseudomonas sp., and P. alcaligenes cells.

6. The host cell of claim 4 wherein the cell is selected from the group consisting of Escherichia sp. (E. coli), Saccharomyces sp. (S. cerevisiae), Panteoa sp. (P. citrea), Bacillus sp. (B. subtilis), Yarrowia sp. (Y. lipolytica), and Trichoderma (T. reesei).

7. The isolated host cell of claim 2, wherein the host cell further comprises a heterologous or native nucleic acid encoding an isopentenyl-diphosphate delta-isomerase (IDI) polypeptide and/or a heterologous or native nucleic acid encoding a 1-Deoxyxylulose-5-phosphate synthase (DXS) polypeptide, optionally in combination with the native 1-deoxy-D-xylulose-5-phosphate (DXP) pathway.

8. The isolated host cell of claim 2, wherein the host cell further comprises one or more nucleic acids encoding an IDI polypeptide and a DXS polypeptide.

9. The isolated host cell of claim 2, wherein the host cell comprises one vector encoding the isoprene synthase variant, the IDI polypeptide, and the DXS polypeptide.

10. The isolated host cell of claim 9 wherein the host cell further comprises a heterologous nucleic acid encoding a mevalonate (MVA) pathway polypeptide selected from the group consisting of an MVA pathway polypeptide from Saccharomyces cerevisiae and Enterococcus faecalis.

11. The isolated host cell of claim 2 wherein the host cell further comprises one or more nucleic acids encoding an MVA pathway polypeptide and a DXS polypeptide and wherein one vector encodes the isoprene synthase variant, the MVA pathway polypeptide, and the DXS polypeptide.

12. The isolated host cell of claim 2 wherein the host cell further comprises one or more nucleic acids encoding a DXS polypeptide, an IDI polypeptide, or one or more of the rest of the DXP pathway polypeptides, and a MVA pathway polypeptide.

13. The isolated host cell of claim 2, wherein the host cell further comprises one or more heterologous nucleic acid(s) encoding an MVA pathway polypeptide.

14. The isolated host cell of claim 13, wherein the host cell further comprises one or more nucleic acids encoding an IDI polypeptide.

15. A method of producing isoprene, comprising: (a) providing a host cell of any one of claims 1, 2 and 3-14; and (b) culturing the host cell under conditions suitable for producing isoprene.