### POLYMETHYLENE POLYPHENYL ISOCYANATE CASRN: 9016-87-9

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or other data, click on the Table of Contents



### Human Health Effects:

Evidence for Carcinogenicity: N o data are available in humans. No data are available in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. S7 70 (1987)] **PEER REVIEWED**

WEIGHT OF EVIDENCE CHAR ACTERIZATION: Under U.S. EPA's 1996 Guidelines for Carcinogenic Risk Assessment, monom eric MDI or polymeric MDI (PMDI) would be classified as not classifiable or a Group D chemical. Under U.S. EP A's 1996 Proposed Guidelines for Carcinogenic Risk Assessment, the carcinogenic potential of MDI/PMDI would be characte rized as "cannot be determined, but for which there is suggestive evidence that raises concern for carcinogenic effects" on the following basis. The increased incidence of pulmonary adenomas in male (6/60) and female (2/59) Wistar rats [strain Cpu:WU] and one pulmonary adenocarcinoma in a male rat, all exposed to the highest concentration in a lifetime chroni c inhalation study involving PMDI, s uggest that PMDI has tumorigenic
p otential. However, the tumorigenic result s, coupled with evidence that methylene diphenyl aniline (MDA) a known animal carcinogen and the principal reaction product of MDI, is found in blood of MDI-exposed rats and nonhydrolyzed urine of PMDI /MDI-exposed humans increa ses concern about the carcinogenic potential of PMDI/MDI. The available human evidence is inadequate to describe the carcinogenic potential of PMDI /MDI. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Limited. [U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) for Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) (101- 68-8, 9016-87-9) Available from: http://www.epa.gov/ngispgm3/iris on the Substance File List as of March 15, 2000] **QC REVIEWED**

Human Toxicity Excerpts: Isocyanates are irritating to the skin and the mu cous membranes, the skin conditions ranging from localized itching to more or less widespread eczema. Eye affections ar e less common and, although lacrimation is often found, conjuncti vitis is rare. The commonest a nd most serious troubles, however, are those affecting the respirat ory systems. /Isocyanates/ [International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 1161] **PEER
REVIEWED**

Populations at Special Risk: Persons with a history of asthma, allergies ... or impaired lung or pulmonary function may be at an increased risk. /Methyl isocyanate/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81- 123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 1]
**PEER REVIEWED** Iris Camacho, 6308MM Pa g e 1 of 14

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### Emergency Medical Treatment:

Emergency Medical Treatment: EMT Copyright Disclaimer: Portions of the POISINDEX(R) and MEDITEXT(R) database have been provided here for general reference. THE COMPLETE PO ISINDEX(R) DATABASE OR MEDITEXT(R) DATABASE SHOULD BE CONSULTED FOR ASSISTANCE IN THE DIAG NOSIS OR TREATMENT OF SPECIFIC CASES. The use of the POISINDEX(R) a nd MEDITEXT(R) databases is at your sole risk. The POISINDEX(R) and MEDITEXT(R) databases are provided "AS IS" and "as available" for use, without warranties of any kind, either expressed or implied. Mi cromedex makes no representation or warranty as to the accuracy, reliabil ity, timeliness, usefulness or comple teness of any of the information contained in the POISINDEX(R) and MEDITEXT(R) databases. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Micromedex does not as sume any responsibility or risk for your use of the POISINDEX (R) or MEDITEXT(R) databases. Copyright 1974-2009 Thomson MICR OMEDEX. All Rights Reserved. Any duplication, replicati on, "downloading," sale, redistributi on or other use for commercial purposes is a violation of Micromedex ' rights and is strictly prohibited.

The following Overview, *** IRRITANTS ***, is re levant for this HSDB record chemical. Life Support:
o This overview assumes that basic life support measures have been instituted. Clinical Effects:

0.2.1 SUMMARY OF EXPOSURE 0.2.1.1 ACUTE EXPOSURE A) Whether a substance is labeled a "corrosive" or "irritant" depends on several factors: the nature of the substance, concentration, viscosity, pH, molarity, oxidation-reduction potential, complexing affinity toward bivalent ions etc. It is difficult to determine if a substance is a corrosive or irritant at a particular concentration. B) Irritants are substances that cause inflammation and swelling, but not cellular death and tissue damage; a corrosive causes cellular damage and death. C) Exposure via inhalation may result in headache, rhinorrhea, cough, shortness of breath, chest pain, bronchospasm and rarely, upper airway swelling or acute lung injury. D) Ingestion may cause irritation of the oral mucous membranes and esophagus. 0.2.4 HEENT 0.2.4.1 ACUTE EXPOSURE A) Irritants may cause swelling, redness and pain at any site, especially at mucous membranes. The mouth, nose, and eyes are susceptible to these effects.
0.2.6 RESPIRATORY 0.2.6.1 ACUTE EXPOSURE A) Cough, tachypnea, and wheezing are common after inhalation.
0.2.8 GASTROINTESTINAL Iris Camacho, 6308MM Pa g e 2 of 14

9/28/2009 htt p ://toxnet.nlm.nih. g ov/c g i- b in/sis/search/f?./tem p /~AO j me q :2:FULL0.2.8.1 ACUTE EXPOSURE A) Nausea, vomiting and diarrhea are possible if ingested.
0.2.14 DERMATOLOGIC 0.2.14.1 ACUTE EXPOSURE A) Redness, swelling and pain may occur.
0.2.20 REPRODUCTIVE HAZARDS A) Pregnant female rats were exposed to N- methylpyrrolidone. Exposed offspring had normal motor function, activity levels, and low-level learning abilities. On higher-level learning tests, their performance was impaired compared to unexposed offspring.
0.2.21 CARCINOGENICITY 0.2.21.2 HUMAN OVERVIEW A) Development of sinonasal neoplasms has been associated with exposure to wood dust and other irritants. Laboratory:
A) No specific laboratory tests are necessary with the possible exception of testing the pH of the irritant substance and the pH of the ocular cul de sac with wide range pH paper. Treatment Overview:

0.4.2 ORAL EXPOSURE A) EMESIS - Not indicated due to the irritant nature of these agents. B) Charcoal - Not recommended; it may promote vomiting and make endoscopic evaluation difficult. C) DILUTION: Immediately dilute with 4 to 8 ounces (120 to 240 mL) of water or milk (not to exceed 4 ounces/120 mL in a child). D) NEUTRALIZATION - Neutralization is not indicated. E) Although these agents are irritants, and therefore should not produce tissue damage, it is almost impossible to assure that a particular substance under a particular set of circumstances would not cause damage. Therefore, each patient should be examined with the idea that mucous membrane damage might have occurred.
0.4.3 INHALATION EXPOSURE A) INHALATION: Move patient to fresh air. Monitor for respiratory distress. If cough or difficulty breathing develops, evaluate for respiratory tract irritation, bronchitis, or pneumonitis. Administer oxygen and assist ventilation as required. Treat bronchospasm with inhaled beta2 agonist and oral or parenteral corticosteroids.
0.4.4 EYE EXPOSURE A) DECONTAMINATION: Irrigate exposed eyes with copious amounts of room temperature water for at least 15 minutes. If irritation, pain, swelling, lacrimation, or photophobia persist, the patient should be seen in a health care facility. B) If in a medical facility, sterile saline should be used to irrigate the eyes until the cul de sac is returned to neutrality. Some alkali exposures may require prolonged irrigation. Range of Toxicity:

A) The extent of damage will depend on a number of factors including concentration, mechanism of action, pH, free Iris Camacho, 6308MM Pa g e 3 of 14

9/28/2009 htt p ://toxnet.nlm.nih. g ov/c g i- b in/sis/search/f?./tem p /~AO j me q :2:FULL[Rumack BH POISINDEX(R) Information System Micromedex, Inc., Englewood, CO, 2009; CCIS Volume 142, edition expires Nov, 2009. Hall AH & Rumack BH (Eds): TOMES(R) Information System Micromedex, Inc., Englewood, CO, 2009; CCIS Volume 142, edition expires Nov, 2009.] **PEER REVIEWED**

Antidote and Emergency Treatment: N oncardiogenic pulmonary edema and bronchospasm are the most immediat e serious clinical consequences of isocyanate exposure. Mark edly symptomatic patients should receive oxygen, ventilatory support, and an intravenous line. Trea tment for asthma includes inhaled sympathomimetics (salbutamol, metaproterenol), intravenous theophyl line, parenteral sympat homimetics (epinephrine, terbutaline), and ster oids. /Isocyanates/ [Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988., p. 881]
**PEER REVIEWED**

Most treatment is symptomatic. Mydriatics, systemic analgesics, and topical antibiotics (Sulamyd) may be used for corneal abrasions. There is no effectiv e therapy for sensitized workers, and these people should be moved to a work si te devoid of exposure to isocyanates. /Isocyanates/ [Ellenhorn, M.J. and D.G. Barceloux. Medical Toxicology - Diagnosis and Treatment of Human Poisoning. New York, NY: Elsevier Science Publishing Co., Inc. 1988., p. 881]
**PEER REVIEWED**



### Animal Toxicity Studies:

Evidence for Carcinogenicity: N o data are available in humans. No data are available in animals. OVERALL EVALUATION: Group 3: The agent is not classifiable as to its carcinogenicity to humans. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. S7 70 (1987)] **PEER REVIEWED**

WEIGHT OF EVIDENCE CHAR ACTERIZATION: Under U.S. EPA's 1996 Guidelines for Carcinogenic Risk Assessment, monom eric MDI or polymeric MDI (PMDI) would be classified as not classifiable or a Group D chemical. Under U.S. EP A's 1996 Proposed Guidelines for Carcinogenic Risk Assessment, the carcinogenic potential of MDI/PMDI would be characte rized as "cannot be determined, but for which there is suggestive evidence that raises concern for carcinogenic effects" on the following basis. The increased incidence of pulmonary adenomas in male (6/60) and female (2/59) Wistar rats [strain Cpu:WU] and one pulmonary adenocarcinoma in a male rat, all exposed to the highest concentration in a lifetime chroni c inhalation study involving PMDI, s uggest that PMDI has tumorigenic
p otential. However, the tumorigenic result s, coupled with evidence that methylene diphenyl aniline (MDA) a known animal carcinogen and the principal reaction product of MDI, is found in blood of MDI-exposed rats and nonhydrolyzed urine of PMDI /MDI-exposed humans increa ses concern about the carcino g enic potential of PMDI/MDI. The available human evidence is inadequate to describe the acidity and alkalinity, molarity and oxidation-reduction potential. In most cases these factors are more important than volume. Besides its irritant effect, a substance may also have some type of systemic effect. Observe for any potential systemic effects as is appropriate for each compound. Iris Camacho, 6308MM Pa g e 4 of 14

9/28/2009 htt p ://toxnet.nlm.nih. g ov/c g i- b in/sis/search/f?./tem p /~AO j me q :2:FULLcarcinogenic potential of PMDI /MDI. HUMAN CARCINOGENICITY DATA: Inadequate. ANIMAL CARCINOGENICITY DATA: Limited. [U.S. Environmental Protection Agency's Integrated Risk Information System (IRIS) for Methylene Diphenyl Diisocyanate (monomeric MDI) and polymeric MDI (PMDI) (101- 68-8, 9016-87-9) Available from: http://www.epa.gov/ngispgm3/iris on the Substance File List as of March 15, 2000] **QC REVIEWED**

TSCA Test Submissions: Acute oral toxicity was evaluated in groups of 5 ma le albino rats (strain not reported) administered single doses of polymethylene polyphenylisocyanate (PAPI) at levels of 1000, 2150, 5000 and 10,000 mg/kg of body weight. Mortality was not observed in any animal; the LD50 value was reported to be >10,000 mg/kg of body weight. Clini cal observations included salivation, nasal discharge and an abnormal yellow urine excretion. Gro ss necropsy revealed no abnormalities. [International Research and Development Corporation; Acute Toxicity Studies (LD50) in Male Albino Rats. (1964), EPA Document No. 86-870000590, Fiche No. OTS0515117]
**UNREVIEWED**

Acute oral toxicity was evaluated in ChR-CD male rats (number not reported) administered single doses of polymethylene polyphenyl isocyanate by oral ga vage at levels of 2250, 5000, 7500, 11000, 17000, and 25000 mg/kg of body weight. Mortality was observed within 14 days after dosing at a dose level of 17000 mg/kg; the approximate lethal dose was dete rmined to be 17000 mg/kg of body weight. Weight loss was observed in animals at doses of 11000 mg/kg and below. Clinical observations were not reported. Gross necropsy revealed eroded and thickene d stomach mucosa as well as masses in the stomach. Microscopic histop athology discovered depletion of thymoc ytes, reduced liver cell vacuolation and focal inflammation of the liver. [Haskell Laboratory for Toxicology and Industrial Medicine; Acute oral Testing in Male Rats, (1967), EPA. Doc. No. 86-870001117, Fiche No. OTSO516020] **UNREVIEWED**

Acute dermal toxicity was evaluated in groups of 2 male and 2 female albino rabbits (strain not reported) receiving single occlude d applications of undiluted polymethylene polyphenylisocyanate at dose levels of 2.5, 3.9, 6.0 a nd 9.4 g/kg of body weight. The test article was held in contact with the skin (half intact, half abraded) for a 24 hour period. Mo rtality was not observed in any animal. Clinical observations included slight erythe ma and slight coriaceousness at a pplication site. Gross necropsy revealed no effects attributable to the test material. [International Research and Development Corporation; Acute Dermal Toxicity Studies (LD50) in the Albino Rabbit, (1964), EPA Document No. 86870000591, Fiche No. OTS0515118] **UNREVIEWED**

Acute inhalation toxicity was evaluated in groups of 6 male albino Spartan Sprague-Dawley rats exposed to polymethylene polyphenylisocyanate vapor at analyt ical concentrations of 14.7 or 17.0 mcg/L for 1 hour. The test atmosphere was generated by passing air over test material that had been injected into a heated (150 deg C) distillation flask with an infu sion pump. Mortality was not observed in any animal; an LC50 value was not reported. Clinical obser vations included slight salivation and erythema. Gross necropsy revealed lung congestion. [International Research and Development Corporation; Acute Inhalation Toxicity (LC50) in the Male Albino Rat, (1965), EPA Document No. 86870000660, Fiche No. OTS0515187] **UNREVIEWED**

Potential of 4 Polyurethane In termediates: 4,4'-Diphenylmethane Diisocyanate (MDI), Polymethylene Polyphenylene Polyisoc yanate (Poly-MDI), Polymethylene Polyphenylene Polyamine (Poly-MDA), and 2,4-Tolylene Diisocyanate (TDI), (1967), EPA Doc. No. 86-890000191, Fiche No. OTS0516728] Acute inhalation toxicity was evalua ted in 6 Long-Evans rats (sex dist ribution not reported) exposed to Iris Camacho, 6308MM Pa g e 5 of 14

9/28/2009 htt p ://toxnet.nlm.nih. g ov/c g i- b in/sis/search/f?./tem p /~AO j me q :2:FULLpol y meth y lene polyphenylene polyisocyanate vapors for one 4-hour period (concen tration level not reported). No mortalities were obs erved (LD50 not reported). Clinical observations included respiratory distress in the form of rales. Gross necr opsy revealed no treatment-related changes. [BASF Corp.; An Evaluation of the Acute Toxicity and Irritantcy [sic]]
**UNREVIEWED**

Polymeric methylene diphenyldiisocyanate (MDI) ae rosol was tested for carcinogenicity and chronic toxicity in 70 male and 70 female SPF-reared rats (Cpb:WU, Wistar random) (60/sex/group in a main group and 10/sex/group in a satellite group) exposed by inha lation to 0, 0.2, 1.0 or 6.0 mg/cu.m 6 hours/day, 5 days/week for 2 years (main group) or 1 year (satellite group). Mortality rates were negatively related to the concentrat ion level. Effects observed at mid- and high-concentrations included a higher degree of basal ce ll hyperplasia frequently accompanied by hyperplasia of Bowman's glands in the olfactory epithelium of the nose, alveolar duct epithelialisation (repla cement or transformation of flat epithelium), and alveolar duct fibrosis in tissues surrounding macrophage accumulations. Effects observed at all exposure levels included accumula tions of alveolar macr ophages containing MDIassociated material at the level of the alveolar duct in the lungs. Effects observed only in highconcentration rats include d increases in lung weights, calcareous particles in the lungs and localized areas of alveolar bronchi olisation (bronchiolar/alveolar hyperp lasia), 8 pulmonary adenomas, and 1
p ulmonary adenocarcinoma. [TNO-CIVO Institute; Chronic Toxicity/Carcinogenicity Inhalation Study of Polymeric Methylenediphenyl Diisocyanate Aerosol in Rats, (1990), EPA Document No. 86- 900000439, Fiche No. OTS0525557] **UNREVIEWED**

The mutagenicity of isocyanic aci d, poly(methylenephenyl) ester was evaluated in Salmonella tester strains TA1535, TA1537 and TA1538 (Ames test) both in the presence and absence of added metabolic activation by Aroclor-induced rat live r S9 fraction. The test material was tested for mutagenicity at concentrations of 10, 50, 100, 150, 200, and 250 ug/plat e by the direct plate incorporation method. Isocyanic acid, poly(methylen ephenyl) ester did not cause a reproducib le positive response in any of the tester strains either with or without metabol ic activation. [EI Dupont De Nemours & Co.; In Vitro Microbial Mutagenicity Studies of Isocyanic Acid, Poly(Methylenephenyl) Ester with Attachments, (1975), EPA Doc. No. 86- 870000996, Fiche No. OTS0514898] **UNREVIEWED**



### Metabolism/Pharmacokinetics:

Pharmacology:

Environmental Fate & Exposure:

Environmental Standards & Regulations:

TSCA Requirements: Pursuant to section 8(d) of TSCA, EPA promulgate d a model Health and Safety Data Reporting Rule. The section 8(d) model rule requires manufacturers , importers, and processors of listed chemical substances and mixtures to submit to EPA copies and lists of unpubl ished health and safety studies. Isocyanic acid, polymethylen epolyphenylene ester is included on this list. [40 CFR 716.120 (7/1/94)] **PEER REVIEWED** Iris Camacho, 6308MM Pa g e 6 of 14

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### Chemical/Physical Properties:

Molecular Formula: UVCB

**PEER REVIEWED**

Color/Form: DARK-AMBER VISC OUS LIQUID [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 316 (1979)] **PEER REVIEWED**

Density/Specific Gravity: 1.2 @ 20 DEG C/20 DEG C [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 316 (1979)] **PEER REVIEWED**

Vapor Pressure: LESS THAN 1X10-4 MM HG @ 25 DEG C [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 316 (1979)] **PEER REVIEWED**

Other Chemical/Physical Properties: ISOCYANATE EQUIVALENT 132-137 G/EQUIV; HYDROLYZABLE CHLORIDE 0.28-0.5%; ISOCYANATE CONTENT 30.5-32% MIN [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 316 (1979)] **PEER REVIEWED**

ACIDITY AS HYDROCHL ORIC ACID 0.2-0.3% [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 316 (1979)] **PEER REVIEWED**

Boiling point is 196 deg C at 5 mm Hg; melting poi nt is 38 deg C. Soluble in acetone, benzene, kerosene, nitrobenzene /Methyl Diphenyl Diisocyanate / [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 316 (1979)] **PEER REVIEWED**



### Chemical Safety & Handling:

Flash Point: Iris Camacho, 6308MM Pa g e 7 of 14

9/28/2009 htt p ://toxnet.nlm.nih. g ov/c g i- b in/sis/search/f?./tem p /~AO j me q :2:FULL215-218 DEG C [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 316 (1979)] **PEER REVIEWED**

Fire Fighting Procedures: Persons involved in fighting fires s hould wear a self-contained breathing apparatus with a full facepiece operated in a pressure-demand or other posit ive pressure mode. ... /Methyl isocyanate/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81- 123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 2]
**PEER REVIEWED**

Protective Equipment & Clothing: Vapor Concentration: 0.2 ppm or less: Any supplie d-air respirator or a ny self-contained breathing apparatus. 1 ppm or less: Any suppl ied-air respirator with a full facepiece, helm et, or hood or any selfcontained breathing apparatus with a full facepiec e. A type C supplied air respirator operated in a
p ressure-demand or other positive pressure or conti nuous flow mode. 20 ppm or less: A type C suppliedair respirator with a full facepiece operated in pressu re-demand or other positive pressure mode or with a full facepiece, helmet, or hood opera ted in continuous-flow mode. Gr eater than 20 ppm or entry and escape from unknown concen trations: Self-contained breathing appa ratus with a full facepiece operated in a pressure-demand or ot her positive pressure mode or a combination respirator which includes a type C supplied-air respirator with a full facepiece operate d in pressure-demand or other positive pressure or continuous-flow mode and an auxili ary self-contained breathing appara tus operated in pressure-demand or other positive pressure mode. Escape: Any es cape self-contained breat hing apparatus. /Methyl isocyanate/ [Mackison, F. W., R. S. Stricoff, and L. J. Partridge, Jr. (eds.). NIOSH/OSHA - Occupational Health Guidelines for Chemical Hazards. DHHS(NIOSH) Publication No. 81- 123 (3 VOLS). Washington, DC: U.S. Government Printing Office, Jan. 1981., p. 5]
**PEER REVIEWED**

Stability/Shelf Life: LOW VOLATILITY [International Labour Office. Encyclopedia of Occupational Health and Safety. Vols. I&II. Geneva, Switzerland: International Labour Office, 1983., p. 1161] **PEER
REVIEWED**

Disposal Methods: SRP: At the time of review, criter ia for land treatment or burial (sanit ary landfill) dispos al practices are subject to significant revision. Pr ior to implementing land disposal of waste residue (including waste sludge), consult with environmental regulatory agenci es for guidance on acceptable disposal practices.

**PEER REVIEWED**



### Occupational Exposure Standards:

Manufacturing/Use Information: Iris Camacho, 6308MM Pa g e 8 of 14

9/28/2009 htt p ://toxnet.nlm.nih. g ov/c g i- b in/sis/search/f?./tem p /~AO j me q :2:FULLMajor Uses: PMDI IS THE SOURCE OF PURE DIPHENYLMETHANE-4,4'- DIISOCYANATE , USED AS A BINDER RESIN FOR PARTICLE BOARD AND AS A FOUNDRY CORE BINDER RESIN [CHEMICAL PRODUCT SYNOPSIS: METHYL DIPHENYL DIISOCYANATE, 1984] **PEER REVIEWED**

POLYURETHANE ELASTOMERS BASED ON POLYMETHYLENE POLYPHENYL ISOCYANATE ARE USED IN MICROCELLU LAR PRODUCTS, INCLUDING SHOES & AUTOMOBILE BUMPERS. ADDITIONAL APPL ICATIONS...INCLUDE PRODUCTION OF POLYURETHANE ADHESIVES...& FOUNDRY RESI N SAND BINDERS USED IN CASTING OF STEEL...IRON & NONFERROUS METALS. [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 317 (1979)] **PEER REVIEWED**

Manufacturers: Miles Inc, One Mellon Center , 500 Grant Street, Pittsbur gh PA 15219-2502 (412)394-5500. Production sites: Polymers Division, Polyurethane- Baytow n, TX 77521 and New Martinsville, West Virginia 26155 /Methyl Diphenyl Diisocyanate / [SRI. 1994 Directory of Chemical Producers -United States of America. Menlo Park, CA: SRI International, 1994., p. 700] **PEER REVIEWED**

Dow Chemical USA, 2020 Dow Center, Midlan d, MI 48674 (517)636-1000 Production site: Polymer Chemicals Division LaPorte, TX /Methyl Diphenyl Diisocyanate / [SRI. 1994 Directory of Chemical Producers -United States of America. Menlo Park, CA: SRI International, 1994., p. 700] **PEER REVIEWED**

ICI Americas, Inc, Wilminton, DE 19850 (302) 887-3000. Production site: IC I Materials, ICI Polyurethanes Group- Geismar, LA 70734 /Methyl Diphenyl Diisocyanate / [SRI. 1994 Directory of Chemical Producers -United States of America. Menlo Park, CA: SRI International, 1994., p. 700] **PEER REVIEWED**

Methods of Manufacturing: MDI & POLYMETHYLENE POLYPHENYL ISOCYANATE ARE PRODUCED COMMERCIALLY BY FOLLOWING STEPS: (1) ANILINE IS CONDENSED WITH FORMALDEHYDE TO GIVE DIPHENYLME THANE DIAMINE...(2) DIAMINE IS PHOSGENATED, WHICH RESULTS IN MIXTURE OF AROMATIC ISOCYANATES... [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 317 (1979)] **PEER REVIEWED**

ARCO HAS DEVELOPED A PROCESS INVOLV ING THE REACTION OF NITROBENZENE, CARBON MONOXIDE, AND AN ALCOHOL TO YIELD POLYMERIC ISOCYANATES DIRECTLY [CHEMICAL PRODUCT SYNOPSIS: METHYL DIPHENYL DIISOCYANATE, 1984] **PEER REVIEWED**

General Manufacturing Information: A POLYMER OF DIPH ENYLMETHANE 4,4'- DIISOCYANATE

... [Lewis, R.J., Sr (Ed.). Hawley's Condensed Chemical Dictionary. 12th ed. New York, NY: Van Nostrand Rheinhold Co., 1993, p. 938] **PEER REVIEWED** Iris Camacho, 6308MM Pa g e 9 of 14

9/28/2009 htt p ://toxnet.nlm.nih. g ov/c g i- b in/sis/search/f?./tem p /~AO j me q :2:FULLPOLYMETHYLENE POLYPHENYL ISOCYANATE WAS USED FOR PRODUCTION OF POLYURETHANE RIGID FOAM (80.4-82.8%), PO LYURETHANE FLEXIBLE FOAMS (7.6-8.5%), POLYURETHANE ELASTOMERS (2.7-3.2%) & OTHE R POLYURETHANE A PPLICATIONS (7.1- 7.9%). [IARC. Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Man. Geneva: World Health Organization, International Agency for Research on Cancer, 1972-PRESENT. (Multivolume work)., p. V19 317 (1979)] **PEER REVIEWED**

CROSS-LINKED, NYLON-TYPE POLYMER PREPD BY REACTION OF MIXT OF SEBACOYL CHLORIDE & POLYMETHYLENE POLY(PHENYLISOCYANATE) WITH MIXT OF ETHYLENEDIAMINE & DIETHYLENETRIAMINE IS EXEMPT ED FROM REQUIREMENT OF TOLERANCE WHEN USED AS ENCAPSULATING MATERIAL FO R METHYL PARATHION. [CROSS-LINKED, NYLON-TYPE POLYMER. EXEMPTION FROM THE REQUIREMENT OF TOLERANCE; FED REGIST 39 (52): 9965-6 (1974)] **PEER REVIEWED**

Polymethylene polyphenyl isocyanate is a crude product wh ich varies in its exact composition. The main constituents are 40-60% 4,4'-MDI ; the remainder is the other isomer s of MDI, trimeric species and higher molecular weight oligomers. [Kirk-Othmer Encyclopedia of Chemical Technology. 4th ed. Volumes 1: New York, NY. John Wiley and Sons, 1991-Present., p. V23 581] **PEER REVIEWED**

CONTROLLED-RELEASE PESTICIDE GR ANULES ARE PREPD BY USING POLYISOCYANATES OR POLYISOCYANATE PREPOLYMERS AS MAIN FORMULATION INGREDIENT. [HEINRICH R ET AL; BIOLOGICALLY ACTIVE GRANULES: GER OFFEN PATENT 2743485 03/29/79 (HOECHST A-G)] **PEER REVIEWED**

Consumption Patterns: ALMOST EXCLUSIVELY AS A MONOMER WITH POLYETHER & POLYESTER POLYOLS TO PRODUCE POLYURETHANE PRODUCTS, OF WHICH ABOUT 81% ARE RIGID FOAMS, ABOUT 8% ARE FLEXIBLE FOAMS, ABOUT 8% ARE ADHESIVES, FOUNDRY RESINS, & RIGID RIM (STRUCTURAL FOAMS), AND ABOUT 3% ARE ELASTOMERS (1975)

**PEER REVIEWED**

END USE PATTERN (DERIVATIVE): BUILDING CONSTRUCTION, 45%; APPLIANCES, 15%; TRANSPORTATION, 10%; FURNITURE, 5%; PA CKAGING, 5%; PLASTICS & ELASTOMERS, 15%; MISC, 5% (1983) [CHEMICAL PRODUCT SYNOPSIS: METHYL DIPHENYL DIISOCYANATE, 1984] **PEER REVIEWED**

U. S. Production: (1973) 1.27X10+11 GRAMS

**PEER REVIEWED**

(1984) 2.86X10+11 g [USITC. SYN ORG CHEM-U.S. PROD/SALES 1984 p.25] **PEER REVIEWED**

U. S. Imports: (1972) 9.93X10+8 GRAMS (OTHERS INCLUDED)

**PEER REVIEWED** Iris Camacho, 6308MM Pa g e 10 of 14

9/28/2009 htt p ://toxnet.nlm.nih. g ov/c g i- b in/sis/search/f?./tem p /~AO j me q :2:FULL(1975) 3.49X10+8 G (PRINCPL CUSTMS DISTS)

**PEER REVIEWED**

(1982) 2.5X10+5 g [USEPA; CHIP (DRAFT) METHYLENE DIPHENYLDIISOCYANATE p.5 (1984)] **PEER REVIEWED**

U. S. Exports: (1974) 3.18-3.63X10+10 GRAMS (EST)

**PEER REVIEWED**



### Laboratory Methods:

Analytic Laboratory Methods: ALIPHATIC & AROMATIC ISOCYANATES & THEIR OLIGOMERS WERE DETECTED IN AIR BY HIGH-PERFORMANCE TH IN-LAYER CHROMATOGRAPHY USING 2X10-4 MOLAR SOLN OF 1-(2-PYRIDYL)PIPERAZINE IN METHYL PH ENYL AT RATE OF 1 L/MIN FOR 5-20 MIN. SAMPLES FROM TLC PLATES WERE DETECTED WITH IODOPLATINATE. [ELLWOOD PA ET AL; ANALYST (LONDON) 106 (1258): 85 (1981)] **PEER REVIEWED**

Samples were analyzed using gel permeation of normal phase high pres sure liquid chromatography with fluorescence detection after the de rivatization with tryptamine. The minimum identifiable amount was about 2 ug. [Wu WS et al; Analyst 113: 1209-12 (1988)] **PEER REVIEWED**

Sample collected on a glass fiber fi lter coated with N-)p-nitrobenzyl )-N-n-propylamine as an in situ derivatizing agent. The resulting deri vative is extracted with tetrahydr ofuran, treated successively with acetyl chloride and methanol and anlyzed by size exclusion liquid chromatography using UV-visible detector at 254 nm. Dect eion range 2-155 ppb in air for a 45 L air sample. [Beasley RK, Warner JM; Anal Chem 56: 1604-8 (1984)] **PEER REVIEWED**



### Special References:

Special Reports: Methylene Bisphenyl Isocyanate (MDI) and Polymethylene Polyphenyl Isocyanate . Chemical Hazard Summary, Canadian Centre for Occupa tional Health and Safety, 20: (1987).

Woolrich PF; Toxicology, industrial hygiene and medical control of TD I, MDI and PMPPI. Am Ind Hyg Assoc J 43 (2): 89-97 (1982).



### Synonyms and Identifiers:

Synonyms: ISOCYANATE 580

**PEER REVIEWED** Iris Camacho, 6308MM Pa g e 11 of 14

9/28/2009 htt p ://toxnet.nlm.nih. g ov/c g i- b in/sis/search/f?./tem p /~AO j me q :2:FULLISOCYANIC ACID, POLYMETHY LENEPOLYPHENYLENE ESTER

**PEER REVIEWED**

ISONATE 390P

**PEER REVIEWED**

KAISER NCO 20

**PEER REVIEWED**

MILLIONATE MR

**PEER REVIEWED**

MIRIONATE MR

**PEER REVIEWED**

MONDUR MR

**PEER REVIEWED**

MONDUR MRS

**PEER REVIEWED**

N CO 20

**PEER REVIEWED**

N IAX AFPI

**PEER REVIEWED**

PAPI

**PEER REVIEWED**

PAPI 901

**PEER REVIEWED**

POLYMERIC MDI

**PEER REVIEWED**

POLY(METHYLENE PHENYL ENE ISOCYANATE)

**PEER REVIEWED**

POLYMETHYLENE POLYPHENYLENE ISOCYANATE

**PEER REVIEWED**

POLYMETHYLENEPOLYPHENYLEN E ISOCYANATE POLYMER

**PEER REVIEWED**

POLYMETHYLENEPOLYPHENY LENE POLYISOCYANATE

**PEER REVIEWED**

POLYMETHYLENE POLY(PHENYL ISOCYANATE)

**PEER REVIEWED**

POLYMETHYLENE POLYPHENYL POLYISOCYANATE

**PEER REVIEWED** Iris Camacho, 6308MM Pa g e 12 of 14

9/28/2009 htt p ://toxnet.nlm.nih. g ov/c g i- b in/sis/search/f?./tem p /~AO j me q :2:FULLPOLYMETHYL POLYPHENYL POLYISOCYANATE

**PEER REVIEWED**

POLY(PHENYLENEMETHYL ENE ISOCYANATE)

**PEER REVIEWED**

POLYPHENYLENE POLYMETHYLENE POLYISOCYANATE

**PEER REVIEWED**

POLYPHENYLPOLYMETHYL ENE POLYISOCYANATE

**PEER REVIEWED**

RUBINATE M

**PEER REVIEWED**

SUPRASEC DC

**PEER REVIEWED**

SYSTANAT MR

**PEER REVIEWED**

TEDIMON 31

**PEER REVIEWED**

THANATE P 210

**PEER REVIEWED**

THANATE P 220

**PEER REVIEWED**

THANATE P 270

**PEER REVIEWED**



### Administrative Information:

Hazardous Substances Databank Number: 2011

Last Revision Date: 20021108

Last Review Date: Reviewed by SRP on 9/14/1995

Update History: Complete Update on 11/08/2002, 1 field added/edited/deleted. Complete Update on 02/13/2002, 1 field added/edited/deleted. Complete Update on 01/14/2002, 1 field added/edited/deleted. Complete Update on 08/09/2001, 1 field added/edited/deleted. Complete Update on 05/15/2001, 1 field added/edited/deleted. Complete Update on 03/30/2000, 1 field added/edited/deleted. Complete Update on 02/08/2000, 1 field added/edited/deleted. Iris Camacho, 6308MM Pa g e 13 of 14

9/28/2009 htt p ://toxnet.nlm.nih. g ov/c g i- b in/sis/search/f?./tem p /~AO j me q :2:FULLComplete Update on 09/21/1999, 1 field added/edited/deleted. Complete Update on 08/26/1999, 1 field added/edited/deleted. Complete Update on 08/10/1998, 1 field added/edited/deleted. Complete Update on 02/27/1998, 1 field added/edited/deleted. Complete Update on 10/26/1997, 1 field added/edited/deleted. Complete Update on 01/25/1996, 28 fields added/edited/deleted. Field Update on 01/23/1996, 1 fi eld added/edited/deleted. Complete Update on 12/28/1994, 1 field added/edited/deleted. Complete Update on 03/25/1994, 1 field added/edited/deleted. Complete Update on 08/10/1993, 1 field added/edited/deleted. Field update on 12/23/1992, 1 fiel d added/edited/deleted. Complete Update on 10/01/1990, 1 field added/edited/deleted. Field Update on 03/01/1989, 1 fi eld added/edited/deleted. Complete Update on 10/03/1986 Iris Camacho, 6308MM Pa g e 14 of 14

9/28/2009 htt p ://toxnet.nlm.nih. g ov/c g i- b in/sis/search/f?./tem p /~AO j me q :2:FULL