EX-10.16



 Exhibit 10.16 
  





 
 April 7, 2014 
 Karen
Ferrante 
 150 Adirondack Drive 
 East Greenwich, RI 02818 

Dear Karen: 
 It is my pleasure to extend to you this offer of
employment with Tokai Pharmaceuticals, Inc. (the “Company”). On behalf of the Company, I set forth below the terms of your employment: 
  

	 	1.	Employment. You will be employed to serve on a full-time basis as CMO and Head of Research and Development, effective April 7, 2014. As CMO and Head of Research and Development, you will be
responsible for the oversight of development plus any other duties as may from time to time be assigned to you by the Company. You shall report to the Chief Executive Officer or his/her designee, and you agree to devote your full business time, best
efforts, skill, knowledge, attention and energies to the advancement of the Company’s business and interests and to the performance of your duties and responsibilities as an employee of the Company. Notwithstanding the foregoing, you may
continue to serve on the Board of Directors of Progenics Pharmaceuticals, Inc., provided that doing so does not interfere with you fulfilling your responsibilities as CMO and Head of Research and Development of Tokai. You agree to abide by the
rules, regulations, instructions, personnel practices and policies of the Company and any changes therein that may be adopted from time to time by the Company. 

  

	 	2.	Base Salary. Your base salary will be at the rate of $13,541.67 per semi-monthly pay period (which if annualized equals $325,000), less all applicable taxes and withholdings, to be paid in installments in
accordance with the Company’s regular payroll practices. Such base salary may be adjusted from time to time in accordance with normal business practices and in the sole discretion of the Company. In addition, the Company agrees to compensate
you for the employer paid portion of the current family medical and dental plans offered to employees as long as you are not participating in the plans. 

  

	 	3.	 Signing Bonus. Your signing bonus will be in the amount of $50,000 payable in the first full pay period following the commencement of
your employment. Notwithstanding the foregoing, if you resign for any reason or are terminated by the Company for Cause (as defined below), in either case, prior to July 7, 2014, then you











	 	
shall be obligated to and shall repay the signing bonus in full within 30 days of such resignation or termination. 


 

	 	4.	Discretionary Bonus. Following the end of each calendar year and subject to the approval of the Company’s Board of Directors (the “Board”), you will be eligible for a retention and
performance bonus of up to 20% of your annualized base salary, based on your performance and the Company’s performance during the applicable calendar year, as determined by the Company in its sole discretion. In any event, you must be an active
employee of the Company on the date any bonus is distributed in order to be eligible for and to earn any such bonus award, as it also serves as an incentive to remain employed by the Company. 


 

	 	5.	Equity. Subject to approval by the Board, you will receive an option to purchase, 2,701,653 shares of the Company’s Common Stock at an exercise price per share equal to the fair market value of one
share of the Common Stock as determined by the Board in its sole discretion (the “Option”). The Option would be granted pursuant and subject to the terms of a stock option agreement to be entered into with the Company and under the
Company’s 2007 Stock Incentive Plan (the “Option Agreement”). 

 The Option would vest over a four year
period, with the first twelve and a half percent (12.5%) of the Option vesting on July 1, 2014 and the balance of the Option vesting in 42 equal monthly installments on the first day of each month thereafter, subject to your continued
employment with the Company through each vesting date. 
 Notwithstanding the foregoing, in the event that a Change in Control Event (as
defined in the Option Agreement) occurs or a definitive agreement that results in a Change of Control Event is entered into, in either case, prior to July 7, 2014, then immediately prior to the Change in Control Event, the Option with respect
to 50% of the underlying shares originally covered by the Option (subject to appropriate adjustment for stock splits, stock dividends, recapitalizations and similar events affecting the Common Stock) will terminate and be of no further force or
effect, and the balance of the Option shall continue in force or effect as if it had originally been granted for a number of shares equal to 50% of the underlying shares originally covered by the Option (subject to appropriate adjustment for stock
splits, stock dividends, recapitalizations and similar events affecting the Common Stock). 
 You may also be eligible for other grants of
stock or stock options as determined by and in the sole discretion of the Board. Nothing in this section shall affect your status as an employee at will, as set for below. 
  

	 	6.	Benefits. You may participate in any and all benefit programs that the Company establishes and makes available to its employees from time to time, provided that you are eligible under (and subject to all
provisions of) the plan documents that govern those programs. Benefits are subject to change at any time in the Company’s sole discretion. 


  
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	 	7.	Business Expenses: The Company will reimburse you for all submitted reasonable and documented business expenses in accordance with Company policy. 


 

	 	8.	Vacation. You will be eligible for a maximum of four weeks of paid vacation per calendar year to be taken at such times as may be approved in advance by the Company. The number of vacation days for which
you are eligible shall accrue at the rate of 1.67 days per month that you are employed during such calendar year. Pursuant to Company policy, vacation time cannot be carried over from year to year. 


 

	 	9.	Confidentiality, Inventions, Non-Competition and Non-Solicitation Agreement. You will be required to execute the attached Confidentiality, Inventions, Non-Competition and Non-Solicitation Agreement (the
“Non-Competition Agreement”) as a condition of employment. 

  

	 	10.	No Conflict. You represent that you are not bound by any employment contract, restrictive covenant or other restriction preventing you from entering into employment with or carrying out your
responsibilities for the Company, or which is in any way inconsistent with the terms of this offer letter. 

  

	 	11.	Proof of Legal Right to Work. You agree to provide to the Company, within three (3) days of your date of hire, documentation proving your eligibility to work in the United States, as required by the
Immigration Reform and Control Act of 1986. You may need a work visa in order to be eligible to work in the United States. If that is the case, your employment with the Company will be conditioned upon your obtaining a work visa in a timely manner
as determined by the Company. 

  

	 	12.	At-Will Employment. This letter shall not be construed as an agreement, either express or implied, to employ you for any stated term, and shall in no way alter the Company’s policy of employment
at-will, under which both the Company and you remain free to end the employment relationship for any reason, at any time, with or without cause or notice. Although your job duties, title, compensation and benefits, as well as the Company’s
personnel policies and procedures, may change from time to time, the “at-will” nature of your employment may only be changed by a written agreement signed by you and the Chief Executive Officer of the Company, which expressly states the
intention to modify the at-will nature of your employment. Similarly, nothing in this letter shall be construed as an agreement, either express or implied, to pay you any compensation or grant you any benefit beyond the end of your employment with
the Company, except as otherwise explicitly set forth herein. This letter supersedes all prior understandings, whether written or oral, relating to the terms of your employment. 


 

	 	13.	Termination Without Cause 

  

	 	a.	 Severance. In the event the Company terminates your employment without “Cause” , then, subject to the terms and conditions set forth
in Exhibit A, and provided that you have been employed by the Company for at least six (6) months, and provided further that you execute and return to the Company a 



  
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severance and release of claims agreement provided by and satisfactory to the Company (the “Severance Agreement”) and such Severance Agreement becomes binding and enforceable within 60
calendar days after your termination of employment, the Company will, during the “Severance Period” (as defined below), continue to pay to you as severance pay your then current base salary in accordance with the Company’s then
current payroll practices. As used herein, the “Severance Period” shall commence on the Company’s first payroll period after your Severance Agreement becomes binding (the “Effective Date”), and shall continue until the
earlier of (x) the last day of the Stated Period (as defined herein), and (y) the date on which you commence employment with or begin providing services to another person, employer, or entity; provided, however, that if the foregoing 60
day period would end in a calendar year subsequent to the year in which your employment ends, payments will not be made before the first payroll period of the subsequent year. The Stated Period means (i) if the termination occurs prior to the
first anniversary of the Effective Date, the greater of the number of full months worked from the Effective Date through the date of termination and six (6) months, and (ii) if the termination occurs on the first anniversary of the
Effective Date or thereafter, twelve (12) months. You are required to immediately provide the Company with written notice upon your commencement of employment with or provision of services to another person, employer, or entity. Any severance
pay hereunder will be subject to all applicable taxes and withholdings. You shall not be entitled to any severance pay if your employment is terminated by the Company for Cause, or if you resign your employment with the Company for any reason. 

 

	 	b.	Cause. For purposes of this Section 13, the term “Cause” means: (x) your conviction of, or plea of guilty or nolo contendere to, any crime involving dishonesty or moral turpitude or any
felony; or (y) a good faith finding by the Company that you have (i) engaged in dishonesty, willful misconduct or gross negligence,(ii) breached or threatened to breach the Non-Competition Agreement, (iii) violated Company policies or
procedures, and/or (iv) failed to perform your assigned duties to the Company’s satisfaction, following notice of such failure by the Company and a period of fifteen (15) days to cure. 


 

	 	14.	 Legal Costs. You have represented to the Company that the Invention, Non-Disclosure and Non-Competition Agreement between Millennium
Pharmaceuticals, Inc. (“Millennium”) and you, dated August 20, 2007 (the “Millennium Agreement”), contains the only restrictive covenants purporting to bind you, and that you have notified Millennium of the services that you
would provide to the Company as contemplated by this letter. You have further represented to the Company that Millennium has informed you that it does not believe such services would breach the Millennium Agreement or cause you to breach any
other agreement or obligation to Millennium, and that Millennium does not object to your employment with the Company and has represented to you that it will not take any action against you or the Company in connection with your employment with the
Company. Further, you and the Company have agreed that, in performing your services on behalf of the Company, there will be no reason or need for you to disclose or use any information proprietary to




  
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any other person or entity, and the Company has explicitly instructed you not to disclose any such information to the Company or to any other person or entity or to use it in any
way. However, as we have also discussed, it is the Company’s desire not to have any potential dispute with Millennium that might be harmful to, or distract you or other Company representatives from, the Company’s
business. Therefore, provided that you have truthfully represented to the Company Millennium’s position and statements regarding your employment with the Company, the Company shall indemnify you in an amount not to exceed $100,000 against
legal costs that you may incur should Millennium or any or its representatives threaten or bring any action against you for breach of the Millennium Agreement. Nothing herein, however, shall be construed as a promise of employment for any
specific term or alter in any way your status as an employee at will. 
  

	 	15.	Entire Agreement. This letter, together with the Non-Competition Agreement and the Option Agreement , constitute the entire agreement between you and the Company pertaining to their subject matter, and
supersede all previous written or oral representations, agreements and understandings between you and the Company related to the subject matter of this letter and those agreements. Accordingly, upon the Effective Date, the Consulting Agreement dated
December 6, 2013 between you and the Company shall terminate and be of no further force or effect except as provided therein, and your obligations under the Non-Competition Agreement shall apply to Confidential Information, the Materials and
Service-related IP (each as defined in the Consulting Agreement) as if the effective date of this letter and the Non-Competition Agreement were December 6, 2013. 


If this letter correctly sets forth the terms under which you will be employed by the Company, please sign the enclosed duplicate of this letter in the space
provided below and return it to me, along with a signed copy of the Non-Competition Agreement. If you do not accept this offer by April __, 2014, the offer will be deemed withdrawn. 

 

			
	 Sincerely,

		
		 	
	 By:
	 	 /s/ Jodie P. Morrison

		 	Jodie P. Morrison
		 	President and Chief Executive Officer


 The foregoing correctly sets forth the terms of my at-will employment with Tokai Pharmaceuticals, Inc. I am not relying
on any representations other than those set forth above. 
  

					
	 /s/ Karen Ferrante
	  		  	 April 7, 2014

	 Karen Ferrante
	  	Date	  	


  
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 Exhibit A 

Payments Subject to Section 409A 
 1.
Subject to this Exhibit A, payments or benefits under Section 12(a) of the offer letter shall begin only following the date of your “separation from service” (determined as set forth below) which occurs on or after the termination of
your employment. The following rules shall apply with respect to distribution of the payments and benefits, if any, to be provided to you under Section 12(a) of the offer letter, as applicable: 

(a) It is intended that each installment of the payments and benefits provided under Section 12(a) of the offer letter shall be treated
as a separate “payment” for purposes of Section 409A of the Internal Revenue Code of 1986 and the guidance issued thereunder (“Section 409A”). Neither the Company nor you shall have the right to accelerate or defer the
delivery of any such payments or benefits except to the extent specifically permitted or required by Section 409A. 
 (b) If, as of the
date of your “separation from service” from the Company, you are not a “specified employee” (within the meaning of Section 409A), then each installment of the payments and benefits shall be made on the dates and terms set
forth in Section 12(a) of the offer letter. 
 (c) If, as of the date of your “separation from service” from the Company, you
are a “specified employee” (within the meaning of Section 409A), then: 
 (i) Each installment of the payments and benefits
due under Section 12(a) of the offer letter that, in accordance with the dates and terms set forth herein, will in all circumstances, regardless of when your separation from service occurs, be paid within the Short-Term Deferral Period (as
hereinafter defined) shall be treated as a short-term deferral within the meaning of Treasury Regulation Section 1.409A-1(b)(4) to the maximum extent permissible under Section 409A. For purposes of the offer letter, the “Short-Term
Deferral Period” means the period ending on the later of the 15th day of the third month following the end of your tax year in which the separation from service occurs and the 15th day of the third month following the end of the Company’s tax year in which the separation from service occurs; and 

(ii) Each installment of the payments and benefits due under Section 12(a) of the offer letter that is not described in this Exhibit A,
Section 1(c)(i) and that would, absent this subsection, be paid within the six-month period following your “separation from service” from the Company shall not be paid until the date that is six months and one day after such
separation from service (or, if earlier, your death), with any such installments that are required to be delayed being accumulated during the six-month period and paid in a lump sum on the date that is six months and one day following your
separation from service and any subsequent installments, if any, being paid in accordance with the dates and terms 

  
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set forth herein; provided, however, that the preceding provisions of this sentence shall not apply to any installment of payments and benefits if and to the maximum extent that that such
installment is deemed to be paid under a separation pay plan that does not provide for a deferral of compensation by reason of the application of Treasury Regulation Section 1.409A-1(b)(9)(iii) (relating to separation pay upon an involuntary
separation from service). Any installments that qualify for the exception under Treasury Regulation Section 1.409A-1(b)(9)(iii) must be paid no later than the last day of your second taxable year following the taxable year in which the
separation from service occurs. 
 2. The determination of whether and when your separation from service from the Company has occurred shall be made and in
a manner consistent with, and based on the presumptions set forth in, Treasury Regulation Section 1.409A-1(h). Solely for purposes of this Exhibit A, Section 2, “Company” shall include all persons with whom the Company would be
considered a single employer under Section 414(b) and 414(c) of the Code. 
 3. All reimbursements and in-kind benefits provided under the offer letter
shall be made or provided in accordance with the requirements of Section 409A to the extent that such reimbursements or in-kind benefits are subject to Section 409A. 

4. The Company makes no representation or warranty and shall have no liability to you or to any other person if any of the provisions of the offer letter
(including this Exhibit) are determined to constitute deferred compensation subject to Section 409A but that do not satisfy an exemption from, or the conditions of, that section. 

  
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