|                   | Original Contract                                                   | Amendment 1 |
|------------------------|---------------------------------------------------------------------|-------------|
| Patient Specifications |                                                                |        |
|                   | Number of Patients Screened                                         | [****]      | [****] |
|                   | Number of Patients Enrolled                                         | [****]      | [****] |
|                   | Number of Patients Complete                                         | [****]      | [****] |
|                   | Estimated Number of Serious Adverse Events  (per subject) | [****]      | [****] |
| Site Specifications    |                                                                |        |
|                   | Number of Sites                                                     | 8.0         | 10 |
|                   | Number of Qualification Visits                                      | 8.0         | 6 actuals + 2 projected |
|                   | Qualification Visit (duration in days)                              | 0.5         | 0.5 |
|                   | Number of Initiation Visits                                         | 8.0         | 10 |
|                   | Initiation Visit (duration in days)                                 | 1.0         | 1 |
|                   | Number of Interim Monitoring Visits per Site                        | 3.4         | 3.4 |
|                   | Total number of Interim Monitoring Visits                           | 27.0        | 35 |

----

|                              | Interim Monitoring Visit (duration in days)                                                                                                                      | 1.0                     | 1                            |
|-----------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------|-------------------------|------------------------------|
|                              | Number of Close-out Visits                                                                                                                                       | 8.0                     | 10                           |
|                              | Close-out Visit (duration in days)                                                                                                                               | 1.0                     | 1                            |
| CRF Specifications                |                                                                                                                                                             |                    |
|                              | Estimated Unique Pages                                                                                                                                           | 15.0                    | 45                           |
|                              | Estimated Total Pages per Patient                                                                                                                                | 30.0                    | 109                          |
| Project Management Specifications |                                                                                                                                                             |                    |
|                              | Number of Kick-off Meetings                                                                                                                                      | 1.0                     | 1                            |
|                              | Kick-off Meeting (duration in hours)                                                                                                                             | 4.0                     | 4                            |
|                              | Number of Client Project Meetings (face-to-face)                                                                                                                 | 1.0                     | 1                            |
|                              | Number of Client/Clinipace Teleconferences                                                                                                                       | 22 at 0.5hrs/call/month | 30 Calls at 0.5hr/call       |
|                              | Number of Internal Meetings                                                                                                                                      | 11.0                    | 16 Calls at 1hr/call Monthly |
| SAEs                              |                                                                                                                                                             |                    |                         |
|                              | Number of SAEs                                                                                                                                                   | [****]                  | [****]                       |
|                              | Number of Reportable SAEs                                                                                                                                        | [****]                  | [****]                       |
| Statistical Analysis              |                                                                                                                                                             |                    |
|                              | Number of TLF displays (Analysis Datasets (ADs) not included and will need to be scoped in once # of ADs are determined in addition to updates to the TFL count) | 53                      | 53                           |

| Milestone              | Estimated Date per Attachment 1 |                 | Revised Estimated Dates per Amend 1 |
|------------------------|---------------------------------|----------------------|-------------------------------------|
| CPWW Activities Begin  | [****]                          | Pre-Study Activities | [****]                              |
| Final Protocol/ICF     | [****]                          | [****]               |
| IND Submission         | [****]                          |                 |
| Start-up Period Begins | [****]                          | [****]               |
| Start-up Period Ends   | [****]                          | [****]               |

----

| Enrollment Begins        | [****] | Study Activities       | [****] |
|--------------------------|--------|------------------------|--------|
| Enrollment Ends          | [****] | [****]                 |
| Treatment Period Ends    | [****] | [****]                 |
| Collection of Final CRFs | [****] | [****]                 |
| Query Resolution         | [****] | [****]                 |
| Database Lock            | [****] | [****]                 |
| Statistical Analysis     | [****] | Post Dosing Activities | [****] |
| Draft Report             | [****] | [****]                 |
| Final Report             | [****] | [****]                 |
| CPWW Activities End      | [****] | [****]                 |

| Project-specific Tasks                                       | Responsibility  |
|--------------------------------------------------------------|----------------------|
|                                                         | N/A                  | RedHill | CPWW | Joint |
| Clinical Trial Preparation                                   |
| Investigator Brochure Development                            |                 | ý |   |   |
| Protocol/Protocol amendment                                  |                 | ý |   |   |
|  eCRF Preparation                                       |                 |   | ý |   |
| Informed Consent Template Preparation                        |                 |   | ý |   |
| Site-Specific Informed Consent Form Review                   |                 |   | ý |   |
| Central IRB Selection and Management                         |                 |   | ý |   |
| Monitoring Plan Development                                  |                 |   | ý |   |
| Collection of Site Regulatory Documents (Including site IRB) |                 |   | ý |   |
| Regulatory Binders to sites                                  |                 |   | ý |   |
| Regulatory Authority Submission (e.g. FDA, MoH)              |                 | ý |   |   |
| Site selection                                               |                 |   |   | ý |
| Central Laboratory Selection (If needed)                     |                 | ý |   |   |
| Central Laboratory Management and Payment                    |                 | ý |   |   |
| Investigator’s Grant Negotiation                       |                 |   |   | ý |
| Training materials                                           |                 |   |   | ý |
| Project Kick-off Meeting                                     |                 |   |   | ý |
| Investigator’s Study Files Structures                  |                 |   | ý |   |
| CTM Packaging, Labeling and Distribution                     |                 | ý |   |   |
| Monitoring and Trial Management                              |
| Pre-Study visits                                             |                 |   | ý |   |

----

| Site Initiation Visits                                                                                                       |   |   | ý |   |
|------------------------------------------------------------------------------------------------------------------------------|--------|--------|--------|--------|
| Interim Monitoring Visits (approximately 3.5 per site for 10 sites)                                                          |   |   | ý |   |
| Site Close-out Visits                                                                                                        |   |   | ý |   |
| Enrollment Status Reports (none [****] forward)                                                                              |   |   | ý |   |
| SAE reports (none [****] forward)                                                                                            |   |   | ý |   |
| Contact Reports (none [****] forward)                                                                                        |   |   | ý |   |
| Site Management                                                                                                              |   |   | ý |   |
| Study Reference Manual                                                                                                       |   |   | ý |   |
| Project Management                                                                                                           |   |   |   |   |
| Maintenance of Study Master File                                                                                             |   |   | ý |   |
| Schedule Client Meeting / Prepare Minutes – RedHill to Schedule and prepare minutes (with CPWW review); CPWW to attend |   |   |   | ý |
| Study Timelines                                                                                                              |   |   |   | ý |
| Medical Monitoring                                                                                                           |
| Medical Monitoring (maximum of 3 hours/month thru LPO)                                                                       |   |   | ý |   |
| Medical Review (up to [****] - SAEs and [****] - Expedited SAE)                                                              |   |   | ý |   |
| Data Safety Monitoring Board Selection                                                                                       | N/A    |   |   |   |
| Data Safety Monitoring Board Management & Meetings                                                                       | N/A    |   |   |   |
| Pharmacovigilance                                                                                                            |
| Serious Adverse Event Management                                                                                             |   |   | ý |   |
| Regulatory Submission of Adverse Event Reports (RedHill to FDA; CPWW to IRBs)                                                |   |   |   | ý |
| Data Management & Biostatistics                                                                                          |
| Database Design Set-up/Modification (included in eCRF design) Refer to Appendix III for Schedule of Events                   |   |   | ý |   |
| Data Management Plan                                                                                                         |   |   | ý |   |
| Data Coding, AEs, Medications                                                                                                |   |   | ý |   |
| Central Laboratory Data Transfer                                                                                             |   |   | ý |   |
| Randomization Scheme                                                                                                         |   |   | ý |   |
| Statistical Analysis Plan                                                                                                    |   |   | ý |   |
| Prepare Study Tables, Listings and Figures                                                                                   |   |   | ý |   |
| Clinical Study Reports                                                                                                       |
| Provide 2 draft study reports                                                                                                |   |   | ý |   |
| Provide Final Study Report                                                                                                   |   |   | ý |   |
| Publishing                                                                                                                   |   | ý |   |   |
| Quality Assurance                                                                                                            |
| GCP Site Audits                                                                                                              |   | ý |   |   |
| QC Audits of CSRs                                                                                                            |   |   | ý |   |
| QC Audit of Database                                                                                                         | N/A    |   |   |   |

----

| Task                                      | Assumptions                                                                                                                                                                                                        | Current Contract Total (US$) | Amendment 1 Variance | Revised Contract Total (US$) |
|-------------------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|------------------------------|----------------------|------------------------------|
| PROTOCOL DEVELOPMENT AND AMENDMENTS       |                                                                                                                                                                                                               | $ [****]                     | $ [****]             | $ [****]                     |
| Protocol Development                      | Clinipace MD will review the protocol developed by RedHill.  The estimate is based on two review cycles ( administrative changes are not limited to two review cycles)                                   | $ [****]                     | $ [****]             | $ [****]                     |
| Protocol Amendment(s)                     | Clinipace MD will review protocol amendment(s) during the course of this study. We have estimated 2 amendment(s) to the protocol. (Administrative changes/corrections not included for Amendment 2 and any forward | $ [****]                     | $ [****]             | $ [****]                     |
| REVIEW STUDY MATERIALS                    |                                                                                                                                                                                                               | $ [****]                     | $ [****]             | $ [****]                     |
| Review Study Materials                    | General review of study materials by Clinipace Project Team.                                                                                                                                                       | $ [****]                     | $ [****]             | $ [****]                     |
| PROTOCOL DISTRIBUTION AND TRANSLATION     |                                                                                                                                                                                                               | $ [****]                     | $ [****]             | $ [****]                     |
| Distribute Protocol to Sites              | Includes IB                                                                                                                                                                                                        | $ [****]                     | $ [****]             | $ [****]                     |
| Distribute Protocol Amendment(s) to Sites | Based on amendment 1 & 2 for 8 sites.                                                                                                                                                                          | $ [****]                     | $ [****]             | $ [****]                     |
| Protocol Translation                      | Translations will be handled by third party vendors. Includes time to manage the vendors.                                                                                                                          | $ [****]                     | $ [****]             | $ [****]                     |
| eCRF DEVELOPMENT                          |                                                                                                                                                                                                               | $ [****]                     | $ [****]             | $ [****]                     |
| Develop eCRF                              |                                                                                                                                                                                                               | $ [****]                     | $ [****]             | $ [****]                     |
| eCRF Completion Guidelines                | Clinipace will create the eCRF Completion Guidelines.                                                                                                                                                              | $ [****]                     | $ [****]             | $ [****]                     |
| Develop Subject Diary                     |                                                                                                                                                                                                               | $ [****]                     | $ [****]             | $ [****]                     |
| SODA Form                                 | From PDF to MS Word                                                                                                                                                                                                | $ [****]                     | $ [****]             | $ [****]                     |
| INFORMED CONSENT                          |                                                                                                                                                                                                               | $ [****]                     | $ [****]             | $ [****]                     |
| Develop Informed Consent Form (ICF)       | Clinipace will develop the model ICF. RedHill will review and approve the consent. Based on 1 review cycle.                                                                                                        | $ [****]                     | $ [****]             | $ [****]                     |
| Negotiate changes to template with sites  | Clinipace will work with the site(s) on any local changes to the ICF. Clinipace will consult RedHill on any changes from the site(s).                                                                              | $ [****]                     | $ [****]             | $ [****]                     |

----

| Update ICF - Protocol Amendments        | Clinipace will be responsible for updating the ICF based on amendments to the protocol. Based on 1 amendment(s).                                                                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
|-----------------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------|----------|----------|
| Translation of Informed Consent         | Clinipace will work with the sites to translate the Informed Consent into the appropriate language.                                                                                                                                                                                                                                              | $ [****] | $ [****] | $ [****] |
| INVESTIGATOR SELECTION/PRE-STUDY VISITS |                                                                                                                                                                                                                                                                                                                                             | $ [****] | $ [****] | $ [****] |
| Develop Site Recruitment Materials      |                                                                                                                                                                                                                                                                                                                                             | $ [****] | $ [****] | $ [****] |
| Identify and Recruit Investigators      | Clinipace will work to identify 8 investigators willing and able to participate in this trial. Clinipace will provide Sponsor with a list of sites for approval. We have estimated we will need to identify [****] sites to get [****]. 2 additional sites will be recruited from [****] forward based on established feasibility questionnaire. | $ [****] | $ [****] | $ [****] |
| Perform Pre-Study Site Visits - US      | 4 hours on site, avg. 8 hours travel RT, 6 hours prep and reporting = 18 hours.6 conducted thru [****] with 2 additional projected for new sites                                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| CLINICAL TRIAL AGREEMENTS               |                                                                                                                                                                                                                                                                                                                                             | $ [****] | $ [****] | $ [****] |
| Negotiate contracts with sites          | Clinipace will negotiate and hold site contracts and budgets with each site.                                                                                                                                                                                                                                                                     | $ [****] | $ [****] | $ [****] |
| Investigator Grants                     | Clinipace will administer payments to each site. This proposal is based on quarterly payments per site.                                                                                                                                                                                                                                          | $ [****] | $ [****] | $ [****] |
| REGULATORY DOCUMENTS                    |                                                                                                                                                                                                                                                                                                                                             | $ [****] | $ [****] | $ [****] |

----

| Prepare, collect, review appropriate regulatory documents                                         | Clinipace will provide templates to each site including Financial Disclosure Document and 1572, then collect locally required approval documents. This line includes communication with sites to obtain final documents and corrections. Based on 8 sites plus 2 sites from [****] forward. | $ [****] | $ [****] | $ [****] |
|---------------------------------------------------------------------------------------------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------|----------|----------|
| Regulatory Binder                                                                                 | Each site will receive a regulatory binder that contains all required documents.  This binder will be checked at each monitoring visit.   Total of 10 binders will be distributed.                                                                                 | $ [****] | $ [****] | $ [****] |
| Study Procedures Manual                                                                           | A study procedures manual was not developed.                                                                                                                                                                                                                                                | $ [****] | $ [****] | $ [****] |
| Prepare study aids such as drug logs,  etc.                                             |                                                                                                                                                                                                                                                                                        | $ [****] | $ [****] | $ [****] |
| Prepare and submit package to sites for submission to ethics committees.                          |                                                                                                                                                                                                                                                                                        | $ [****] | $ [****] | $ [****] |
| Update documentation for IRBs/ECs - Protocol Amendment(s)                                         | Based on protocol amendment(s) 1 & 2.                                                                                                                                                                                                                                                   | $ [****] | $ [****] | $ [****] |
| Prepare and submit dossier for submission to appropriate Ministry of Health, Track MoH approvals. | RedHill will be responsible for regulatory authority submissions.                                                                                                                                                                                                                           | $ [****] | $ [****] | $ [****] |
| Communication and preparation of official responses to MoH pending issues.                        | RedHill will be responsible for regulatory authority submissions.                                                                                                                                                                                                                           | $ [****] | $ [****] | $ [****] |
| MoH Updates - Protocol Amendment                                                                  | RedHill will be responsible for regulatory authority submissions.                                                                                                                                                                                                                           | $ [****] | $ [****] | $ [****] |
| Annual Reviews (EC)                                                                               | Assume each site will require 1 IRB/IEC renewal(s).                                                                                                                                                                                                                                         | $ [****] | $ [****] | $ [****] |
| Drug Label Review/Translation                                                                     | RedHill will be responsible for packaging and labeling. Clinipace provided review                                                                                                                                                                                                           | $ [****] | $ [****] | $ [****] |
| TRIAL MASTER FILE                                                                                 |                                                                                                                                                                                                                                                                                        | $ [****] | $ [****] | $ [****] |
| Set up Trial Master File                                                                          |                                                                                                                                                                                                                                                                                        | $ [****] | $ [****] | $ [****] |
| Maintain Trial Master File                                                                        |                                                                                                                                                                                                                                                                                        | $ [****] | $ [****] | $ [****] |
| INVESTIGATOR MEETINGS                                                                             |                                                                                                                                                                                                                                                                                        | $ [****] | $ [****] | $ [****] |
| Plan and Manage Investigator Meeting(s)                                                           | Clinipace organize a Web-based Investigator Meeting.                                                                                                                                                                                                                                        | $ [****] | $ [****] | $ [****] |

----

| Prepare meeting binders               | Clinipace will create the meeting binder and ship to the sites. Sponsor will approve the contents of the binder. We have included cost for producing 41 binders.                  | $ [****] | $ [****] | $ [****] |
|---------------------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------|----------|----------|
| Prepare Presentations                 |                                                                                                                                                                              | $ [****] | $ [****] | $ [****] |
| Attend investigator meeting: US       | Webinar                                                                                                                                                                           | $ [****] | $ [****] | $ [****] |
| Project Team Training                 |  We have assumed a 4 hour training session.                                                                                                                                  | $ [****] | $ [****] | $ [****] |
| VENDOR MANAGEMENT                     |                                                                                                                                                                              | $ [****] | $ [****] | $ [****] |
| Central IRB/IEC                       |                                                                                                                                                                              | $ [****] | $ [****] | $ [****] |
| Central Laboratory                    |                                                                                                                                                                              | $ [****] | $ [****] | $ [****] |
| INITIATION VISITS                     |                                                                                                                                                                              | $ [****] | $ [****] | $ [****] |
| Perform Site Initiation Visits - US   | 8 hours on-site, avg. 8 hours travel, 6 hours preparation including slides and protocol review, scheduling and reporting per site = 22 hoursTotal of 10 SIVs budgeted             | $ [****] | $ [****] | $ [****] |
| INTERIM MONITORING VISITS             |                                                                                                                                                                              | $ [****] | $ [****] | $ [****] |
| Develop Monitoring Plan               | Clinipace will complete the monitoring plan/guidelines. Clinipace will provide the draft monitoring plan to RedHill for review and approval. Based on 1 review cycle with RedHill | $ [****] | $ [****] | $ [****] |
| Perform interim monitoring visits: US | 8 hours on-site, 8 hours travel, 6 hours preparation, scheduling and reporting = 22 hours per visit.Total of 35 IMVs included at approximately 3.5 IMVs per site for 10 sites     | $ [****] | $ [****] | $ [****] |
| Extension Visits                      | Based on 5 total additional days on-site at 8 hours each                                                                                                                          | $ [****] | $ [****] | $ [****] |
| Remote Monitoring                     |  7 sites thru [****], 10 sites thereafter thru LPO at an average of 4 hours per site per month                                                                               | $ [****] | $ [****] | $ [****] |
| CLOSE-OUT VISITS                      |                                                                                                                                                                              | $ [****] | $ [****] | $ [****] |
| Perform Close-out visits: US          | 1 day closeout (8 hours) + 8 travel + 6 preparation, scheduling and reporting = 22 hours per visitTotal of 10 COVs budgeted                                                       | $ [****] | $ [****] | $ [****] |
| QUERY RESOLUTION                      |                                                                                                                                                                              | $ [****] | $ [****] | $ [****] |

----

| Query Resolution - Data Lock                            | Clinipace monitors will assist data management with query resolution at study close in order to expedite database lock. Redhill responsible for directly communicating with the sites for all query resolution from [****] forward | $ [****] | $ [****] | $ [****] |
|---------------------------------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------|----------|----------|
| SITE MANAGEMENT                                         |                                                                                                                                                                                                                               | $ [****] | $ [****] | $ [****] |
| In-house Site Management                                | This will be done by assigned CRA, to include in-house site management time during active clinical duration.  Assume routine calls to sites during clinical project duration at 1 hour per site per month.               | $ [****] | $ [****] | $ [****] |
| Lead Clinical Research Associate                        |                                                                                                                                                                                                                               | $ [****] | $ [****] | $ [****] |
| PROJECT COMMUNICATIONS                                  |                                                                                                                                                                                                                               | $ [****] | $ [****] | $ [****] |
| Client Kick-off/Training Meeting                        | Assume a 4 hour kick-off. Training meeting will be held between the Clinipace and Sponsor teams (via teleconference).                                                                                                              | $ [****] | $ [****] | $ [****] |
| Enrollment Reports                                      | Clinipace will provide enrollment reports to the sponsor via Tempo.                                                                                                                                                                |     |     |     |
| Status Reports                                          | Clinipace monthly reports to sponsor, to include screening, enrollment, number of monitoring visits, CRFs harvested; queries outstanding, etc. All reports to be pulled from Tempo by RedHill from [****] forward                  | $ [****] | $ [****] | $ [****] |
| Teleconferences with Sponsor                            | Assume monthly calls with sponsor. From [****] forward: Monthly Calls thru 3rd month of Close-out (12 total calls) at 1hr/call with attendees: PM, MD, SF, DM, ST, ICRA, & CTC                                                 | $ [****] | $ [****] | $ [****] |
| Provide newsletters                                     | Not requested                                                                                                                                                                                                                      | $ [****] | $ [****] | $ [****] |
| External Sponsor / Clinipace Face to Face Team Meetings | Anticipate one meeting at the Sponsor attended by the Clinipace Project Director.                                                                                                                                                  | $ [****] | $ [****] | $ [****] |

----

| CRA Study Management                                                                                                                     | General CRA time for communication with internal team as needed, file maintenance etc. thru DBL at 1hr per CRA per week from [****] forward                                                                                                          | $ [****] | $ [****] | $ [****] |
|------------------------------------------------------------------------------------------------------------------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------|----------|----------|
| Internal Team Meetings                                                                                                                   | Clinipace will hold monthly internal team meetings during the course of this project. From [****] forward: Internal Monthly calls thru 3rd month of Close-out (12 total calls) at 1hr/call with attendees: PM, MD, SF, DM, ST, CRAs, ICRA, & CTC | $ [****] | $ [****] | $ [****] |
| PROJECT MANAGEMENT                                                                                                                       |                                                                                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| Project Management                                                                                                                       | General Project Management to include interaction with monitors; review of all documents and general ad hoc sponsor communication thru [****] only                                                                                                   | $ [****] | $ [****] | $ [****] |
| Project Oversight [****] Forward by Lead CRA (LCRA)                                                                                      | General oversight of project to include ad hoc interaction with internal team and ad hoc communications with Sponsor. Maximum of 3 hours/day from [****] forward                                                                                     | $ [****] | $ [****] | $ [****] |
| Clinical Trial Coordinator - Administrative Support                                                                                      |  Limited Project Administrative support (for LCRA) to maximum of 1 hour per day from [****] forward                                                                                                                                             | $ [****] | $ [****] | $ [****] |
| Financial Reporting                                                                                                                      |                                                                                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| Return Study Files to Sponsor                                                                                                            |                                                                                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| QUALITY ASSURANCE                                                                                                                        |                                                                                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| QA Visits                                                                                                                                | InSymbiosis                                                                                                                                                                                                                                          |     |     |     |
| STUDY DRUG                                                                                                                               |                                                                                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| Obtain import permits for study drug and supplies; prepare and review import paperwork                                                   | InSymbiosis/RedHill                                                                                                                                                                                                                                  | $ [****] | $ [****] | $ [****] |
| Oversee Drug Distribution to Sites from Warehouse                                                                                        | InSymbiosis/RedHill                                                                                                                                                                                                                                  | $ [****] | $ [****] | $ [****] |
| Obtain any necessary export permits for shipping of lab samples to central lab and for return of unused study medication at end of study | Not applicable                                                                                                                                                                                                                                       | $ [****] | $ [****] | $ [****] |
| Drug depot and Central lab contact and local issues management throughout the study                                                      | InSymbiosis/RedHill                                                                                                                                                                                                                                  | $ [****] | $ [****] | $ [****] |

----

| MEDICAL MONITORING                                                                              |                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
|-------------------------------------------------------------------------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------|----------|----------|
| Medical Monitoring Plan                                                                         |                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| Provide medical contact with sites                                                              | Clinipace will provide sites with a contact person to answer site questions. Capped at 3hrs/month thru Last Patient Out (LPO)                                                        | $ [****] | $ [****] | $ [****] |
| Review SAEs                                                                                     |  Total of [****] SAEs                                                                                                                                                           | $ [****] | $ [****] | $ [****] |
| Review patient eligibility, lab alerts, coding and listings                                     |                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| DRUG SAFETY/PHARMACOVIGILANCE                                                                   |                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| Create Safety Monitoring Plan                                                                   | Clinipace will develop the safety plan. Clinipace will provide the draft plan to RedHill Biopharma Ltd. for review and approval. Based on 1 review cycle with RedHill Biopharma Ltd. | $ [****] | $ [****] | $ [****] |
| Set-up SAE Database                                                                             |                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| Document and manage SAEs                                                                        | Based on [****] SAEs.                                                                                                                                                                | $ [****] | $ [****] | $ [****] |
| Follow-up SAEs                                                                                  |                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| Report SAEs to regulatory authorities                                                           | Based on [****] expedited SAEs to IRBs. RedHill responsible for FDA reporting                                                                                                        | $ [****] | $ [****] | $ [****] |
| Update all Study Sites of SAEs requiring Expedited Safety Reports/Distribute IND Safety Reports | Clinipace will notify each site of SAEs that require reporting.                                                                                                                      | $ [****] | $ [****] | $ [****] |
| Write Safety Narratives                                                                         | Based on [****] narratives.                                                                                                                                                          | $ [****] | $ [****] | $ [****] |
| SAE Reconciliation                                                                              | Based on [****] reconciliations throughout the course of the project.                                                                                                                | $ [****] | $ [****] | $ [****] |
| DATA MANAGEMENT                                                                                 |                                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| STUDY PLATFORM                                                                                  |                                                                                                                                                                                 |     |     |     |
| Data Management Fees                                                                            | ▪ Includes License Fees, Hosting and Technical Support                                                                                                                         | $ [****] | $ [****] | $ [****] |
| Hardware & Systems                                                                          | ▪ 3 servers▪ Routers/firewall▪ Tape drive (backup)▪ Redundancy▪ Security (IPS, AVS)▪ Bandwidth                                                   | [****]   | [****]   | [****]   |
| CRF Revisions                                                                                   |                                                                                                                                                                                 | [****]   | [****]   | [****]   |
| IMPLEMENTATION                                                                                  |                                                                                                                                                                                 |     |     |     |

----

| Clinical Data Capture Module               | ▪ XML file creation & load▪ eCRF programming▪ Edit check coding▪ Data element coding▪ Workflow configuration▪ Database development▪ Testing | $ [****] | $ [****] | $ [****] |
|--------------------------------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------|----------|----------|
| Reports                                    |                                                                                                                                                                                      | [****]   |     | [****]   |
| Randomization                              |                                                                                                                                                                                      | $ [****] | $ [****] | $ [****] |
| User Administration                        |                                                                                                                                                                                      | [****]   |     | [****]   |
| Validation (testing & documentation)   |                                                                                                                                                                                      | $ [****] | $ [****] | $ [****] |
| Training Manual                            |                                                                                                                                                                                      | [****]   |     | [****]   |
| User training (TTT)                        |                                                                                                                                                                                      | [****]   |     | [****]   |
| Printable (PDF) CRFs                       |                                                                                                                                                                                      | [****]   |     | [****]   |
| STUDY DATA MANAGEMENT AND SUPPORT          |                                                                                                                                                                                      |     |     |     |
| Data Management Plan                       |                                                                                                                                                                                      | $ [****] | $ [****] | $ [****] |
| Code book creation                         |                                                                                                                                                                                      | [****]   |     | [****]   |
| Data Entry                                 | Not applicable                                                                                                                                                                            |     |     |     |
| Verification                               | Not applicable                                                                                                                                                                            |     |     |     |
| CRF Tracking                               | Not applicable                                                                                                                                                                            |     |     |     |
| Coding                                     | Based on 10 codes per patient.                                                                                                                                                            | $ [****] |     | $ [****] |
| Queries                                    | Based on 10 queries per patient.                                                                                                                                                          | $ [****] |     | $ [****] |
| Data Imports                               | Based on 2 data transfers/imports from outside vendors.                                                                                                                                   | $ [****] |     | $ [****] |
| Data exports/monthly                       |                                                                                                                                                                                      | [****]   |     | [****]   |
| Data export/final                          |                                                                                                                                                                                      | [****]   |     | [****]   |
| Data warehousing/archiving                 |                                                                                                                                                                                      | [****]   |     | [****]   |
| Database Updates                           | Approved [****] via email                                                                                                                                                                 | $ [****] | $ [****] | $ [****] |
| Administration                             |                                                                                                                                                                                      | $ [****] | $ [****] | $ [****] |
| STATISTICAL ANALYSIS                       |                                                                                                                                                                                      | $ [****] | $ [****] | $ [****] |
| Develop Statistical Analysis Plan          | Clinipace will develop the Statistical Analysis Plan. Clinipace will provide the draft analysis plan to RedHill. for review and approval. Based on 1 review cycle with RedHill            | $ [****] | $ [****] | $ [****] |
| Create Randomization Plan                  |                                                                                                                                                                                      | $ [****] | $ [****] | $ [****] |
| Conduct SAS programming and QC of all TLFs | Based on 8 unique tables, 16 non unique tables, 3 unique figures, 6 non unique figures and 20 listings.                                                                                   | $ [****] | $ [****] | $ [****] |
| Analysis Dataset (AD) Programming          | Not included in budget.                                                                                                                                                                   | $ [****] | $ [****] | $ [****] |
| Prepare Interim Analysis and Report        | Not applicable                                                                                                                                                                            |     |     |     |
| Prepare Final Analysis and Report          |                                                                                                                                                                                      | $ [****] | $ [****] | $ [****] |
| QC All Analysis and Report                 |                                                                                                                                                                                      | $ [****] | $ [****] | $ [****] |
| FINAL REPORT                               |                                                                                                                                                                                      | $ [****] | $ [****] | $ [****] |

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| Write Clinical Study Report (CSR) | Clinipace will develop the final report for the study. Clinipace will provide the draft report to RedHill Biopharma Ltd. for review and approval. Based on [****] review cycles with RedHill | $ [****] | $ [****] | $ [****] |
|-----------------------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------|----------|----------|
| TOTAL SERVICES                    |                                                                                                                                                                                         | $ [****] | $ [****] | $ [****] |
| Discount                          |                                                                                                                                                                                         | $ [****] | $ [****] | $ [****] |
| SERVICES COSTS GRAND TOTAL        |                                                                                                                                                                                         | $ [****] | $ [****] | $ [****] |

----

|                                                                                                              | Current Contract |
|-------------------------------------------------------------------------------------------------------------------|------------------|
| Milestone Payments: Pre-IND                                                                                       | $ [****]         |
| Execution of the Agreement - PAID                                                                                 | $ [****]         |
| Protocol and ICF Completed - PAID                                                                                 | $ [****]         |
|                                                                                                              |             |
| Milestone Payments: Post-IND                                                                                      | $ [****]         |
| Initiation of study activities - PAID                                                                             | $ [****]         |
| Database set-up complete (go live) - PAID                                                                         | $ [****]         |
| First Subject Enrolled - PAID                                                                                     | $ [****]         |
| Last Subjects Enrolled ([****] subjects)                                                                          | $ [****]         |
| Last CRF Collected                                                                                                | $ [****]         |
| Final CSR                                                                                                         | $ [****]         |
|                                                                                                              |             |
| Total Milestone Payments                                                                                          | $ [****]         |
|                                                                                                              |             |
| Quarterly Payments: Beginning Post IND                                                                            |             |
| Quarterly Payment 1- Invoice due at 3 months post Initiation of Study Activities - PAID                           | $ [****]         |
| Quarterly Payment 2 –  Invoice due at 6 months post Initiation of Study Activities                | $ [****]         |
| Quarterly Payment  3–  Invoice due at 9months post Initiation of Study Activities       | $ [****]         |
| Quarterly Payment  4–  Invoice due at [****] months post Initiation of Study Activities | $ [****]         |
| Total Quarterly Payments                                                                                          | $ [****]         |
|                                                                                                              |             |
| Total Fee per Attachment A-1                                                                                      | $ [****]         |

----

|  Amendment 1 Execution Payment – [****] payable net 15 days from invoice date  |  $ [****] |
|------------------------------------------------------------------------------------------------|----------------|
|  [****] – due and payable net 30 days from invoice date                        |  $ [****] |
|  [****] – due and payable net 30 days from invoice date                        |  $ [****] |
|  [****] – due and payable net 30 days from invoice date                        |  $ [****] |
|  TOTAL PAYMENTS                                                                      |  $ [****] |

|                                                                                 |  Budget per Month |  Discount |  Total Less Discount |
|--------------------------------------------------------------------------------------|------------------------|----------------|---------------------------|
|  Month 5th ([****]) due and payable net 30 days from invoice date          |  $ [****]         |  $ [****] |  $ [****]            |
|  Month 6th ([****]) due and payable net 30 days from invoice date          |  $ [****]         |  $ [****] |  $ [****]            |
|  Month 7th ([****]) onward, due and payable net 30 days from invoice date  |  $ [****]         |  $ [****] |  $ [****]            |

----

| INDIRECT COSTS                                               | (PASS-THROUGH EXPENSES)                                                                                                                                                        | Current Contract Total (US$) | Amendment 1 Variance | Revised Contract Total (US$) |
|--------------------------------------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|------------------------------|----------------------|------------------------------|
| Ministry of Health and Ethics Committee Fees (IRB Fees)      | Assume 1 initial submission only (no amendments) and 1 annual review(s).                                                                                                       | $24,000                      | $0                   | $24,000                      |
| CRA AirCards                                                 |                                                                                                                                                                           | $1,350                       | $0                   | $1,350                       |
| Shipping                                                     |                                                                                                                                                                           | $5,500                       | $19,850              | $25,350                      |
| Phone (Long Distance)                                        |                                                                                                                                                                           | $5,500                       | $6,617               | $12,117                      |
| Supplies                                                     |                                                                                                                                                                           | $3,300                       |                 | $3,300                       |
| Translation costs                                            | Clinipace will work with the sites and a translation vendor(s) to translate appropriate study documents into local languages. Includes translation into 2 different languages. | $20,000                      | $0                   | $20,000                      |
| Plan and Manage Investigator Meeting(s) with meeting planner | Web-based IM - hosting fees                                                                                                                                                    | $500                         | $0                   | $500                         |
| Travel                                                       | Includes travel for monitoring visits, client meetings, supervision visits, QA visits.                                                                                         | $52,750                      | $21,700              | $73,650                      |
|                                                         |                                                                                                                                                                           |                         |                 |                         |
| ESTIMATED INDIRECT COSTS TOTAL                               |                                                                                                                                                                           | $112,900                     | $48,167              | $161,067                     |

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| Investigator Grants |   | $ [****] |
|---------------------|--------|----------|

| REVISED ACH/Wire Instructions: |
|--------------------------------|

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| CLINIPACE, INC.: |   | RedHill Biopharma Ltd.: |   |
|------------------|--------|-------------------------|--------|
|             |   |                    |   |   |   |
|             |   |                    |   |   |   |
| By:              | /s/    |                    | By:    | /s/ |   |
|             |   |                    |   |   |   |
| Name:            |   |                    | Name:  |   |   |
|             |   |                    |   |   |   |
| Title:           |   |                    | Title: |   |   |
|             |   |                    |   |   |   |
| Date:            |   |                    | Date:  |   |   |