U.S. flag
      An official website of the United States government, Department of Justice.
        Here's how you know
      Here's how you know**Official websites use .gov**
            
            A **.gov** website belongs to an official government organization in the United States.
      **Secure .gov websites use HTTPS**
            
            A **lock** (
            A locked padlock
            ) or **https://** means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites. Menu

      
        close

            
            
                                              About NIJ
        
                    
  
          About NIJ
      
    
          The NIJ Director
          How NIJ Is Organized
          Mission and Guiding Principles
          Research and Development Process
          Strategic Framework
          Assessments of NIJ
          Annual Reports & Reports to Congress
          Staff Directory
          Funding & Awards
        
                    
  
          Funding & Awards
      
    
          Current Funding
          Forthcoming Funding
          Expired Funding
          Awards: Listing of Funded Projects
          Guidance for Applicants and Awardees
          Fellowship & Student Programs
          Travel Scholarships
          NIJ Challenge Program
          Library & Multimedia
        
                    
  
          Library & Multimedia
      
    
          NIJ Journal
          Podcasts
          Publications Listing
          Multimedia Listing
          Rated Practices on CrimeSolutions
          Rated Programs on CrimeSolutions
          Software & Databases
          Datasets
          Patents
          Topics
        
                    
  
          Topics
      
    
          Article Listing
          Corrections
          Courts
          Crime Prevention
          Crimes
          Drugs and Crime
          Equipment and Technology
          Forensic Sciences
          Youth Justice
          Justice System Reform
          Law Enforcement
          Tribal Crime and Justice
          Victims of Crime
          Events
        
                    
  
          Events
      
    
          NIJ 2024 Research Conference
          Scheduled Events
          On-Demand Events
          Research Meetings & Workshops
          NIJ-Hosted Online Training

                            
                                About
          Contact Us
          Subscribe
          Topics A-Z
                  Share
FacebookXLinkedInRedditPinterestEmail Home
                            Funding & Awards
 Improved Tools and Interpretation Guidelines for Examining Limited Low Copy Number DNA Obtained from Degraded Single Source Samples: Bones, Teeth, and Hairs
Award Information
Awardee
              UNT Health Science Center at Fort Worth
Award #
              2009-DN-BX-K188
Funding Category
              Competitive
Location
                    Fort Worth, TX
Congressional District
              12
Status
              Closed
Funding First Awarded
              2009
Total funding (to date)
              $935,992
Original Solicitation
              NIJ FY 09 Forensic DNA Research and Development: Invited Full Proposals
Description of original award (Fiscal Year 2009, $935,992)
The goal of this study is to better define low copy number (LCN) DNA typing by conducting nine different areas of research. Each area would assess a specific aspect as it relates to the analysis of LCN DNA from single source samples: 1) improve extraction efficiency of DNA from skeletal remains, 2) evaluate the performance of the predominant methods for increasing sensitivity of detection for LCN typing, 3) enhance robustness of the amplification by polymerase chain reaction (PCR) for LCN samples, 4) increase the amount of the starting template molecules by whole genome amplification using emulsion PCR, 5) increase the amount of starting template molecules by template circularization and rolling circle amplification, 6) test the efficacy of typing the same template multiple times, 7) test the efficiency of mini-STR DNA analysis for typing LCN samples and develop proper stochastic thresholds, 8) develop positive controls or validation samples for LCN typing, and 9) develop reliable interpretation guidelines and statistical protocols for evaluating the significance of single source LCN profiles. ca/ncf



  
Grant-Funded Publications
        
                      Utility of Amplification Enhancers in Low Copy Number DNA Analysis
                  High Volume Extraction and Purification Method for Recovering DNA from Human Bone
                  Improved Tools for the Robust Analysis of Low Copy Number and Challenged DNA Samples
                  Erratum to: Pressure cycling technology (PCT) reduces effects of inhibitors of the PCR
                  Evaluation of a novel material Diomics X-Swab for collection of DNA
                  Effective removal of co-purified inhibitors from extracted DNA samples using synchronous coefficient of drag alteration (SCODA) technology
                  Erratum to: An evaluation of the transfer of saliva-derived DNA
                  Pressure cycling technology (PCT) reduces effects of inhibitors of the PCR
                  Improved Tools and Interpretation Guidelines for Examining Limited Low Copy Number DNA Obtained From Degraded Single Source Samples: Bones, Teeth, and Hairs
                  An evaluation of the transfer of saliva-derived DNA
                  An evaluation of the transfer of saliva-derived DNA

  
Date Created: September 9, 2009
    
          Side navigation
  

        

  
  
              Current Funding
    
      
            
            
            
      Forthcoming Funding
    
      
            
            
            
      Expired Funding
    
      
            
            
            
      Awards: Listing of Funded Projects
    
      
            
            
            
      Guidance for Applicants and Awardees
    
      
            
            
            
      Fellowship & Student Programs
    
      
            
            
            
      Travel Scholarships
    
      
            
            
            
      NIJ Challenge ProgramSimilar Awards
        
                      911, What's Your Emergency?: Factors Impacting Call Coding
                  A 28-year longitudinal study of victimization and perpetration of violence in high-risk youth: Advancing the development of preventive interventions in the community
                  Empirical Analysis of Saw Mark Characteristics in Human Bone: Meeting Forensic Standards in Dismemberment Cases
 Top

      National Institute of Justice

        
        
                        About NIJ
                    About NIJ
      
    
                  How NIJ Is Organized
      
    
                  NIJ Director
      
    
                  Research Disclaimer
      
    
                  Funding & Awards
                    Funding & Awards Home
      
    
                  Awards Listing
      
    
                  Current Funding
      
    
                  Guidance for Applicants and Awardees
      
    
                  Resources
                    Events
      
    
                  Podcasts
      
    
                  Publications
      
    
                  Topics
      
    
                  Multimedia
      
    
                  Reuse Policy
      
    
                  Contacts
                    Contact NIJ
      
    
                  Staff Directory
      
    
                  Submit a FOIA Request
      
    
                  File a Civil Rights ComplaintFacebook
          
                      X
          
                      YouTube
  

      810 7th St. NW, Washington, D.C. 20531
      
              Secondary Footer link menu
            Accessibility
              Plain Language
              Privacy Policy
              Legal Policies and Disclaimer
              No FEAR Act
              Freedom of Information Act
              USA.gov
              Justice.gov