| 1. | DESCRIPTION OF THE EXTRA WORK |
|----|-------------------------------|

| a. | GMP Omeprazole magnesium API analytical release testing |
|----|---------------------------------------------------------|

| ITEM                                            | Cost (USD$)                                   |
|-------------------------------------------------|-----------------------------------------------|
|                                            |                                          |   |
| ID testing                                      |                                          |
|                                            | IR-Method qualification, set-up and analysis* | 0$ |
|                                            | [****]                                        | 200$ |
|                                            |                                          |   |
| Assay                                           |                                          |
|                                            | Method qualification                          | 2,000$ |
|                                            | Set-up                                        | 605$ |
|                                            | Analysis                                      | 575$ |
|                                            |                                          |   |
| Related substances                              |                                          |
|                                            | Method qualification                          | 2,500$ |
|                                            | Set-up**                                      | 0$ |
|                                            | Analysis                                      | 795$ |
|                                            |                                          |   |
| Residual solvents                               |                                          |
| Method A: [****]                                |                                          |
|                                            | [****]                                        | 14,000$ |
|                                            | Analysis                                      | 1,200$ |
|                                            |                                          |   |
| Water - Karl Fisher Titration (USP <921>) |                                          |
|                                            | Analysis                                      | 165$ |
|                                            |                                          |   |
| Appearance                                      |                                          |
|                                            | Analysis                                      | 85$ |
|                                            |                                          |   |
| [****]                                          |                                          |
|                                            | Analysis                                      | 75$ |
|                                            |                                          |   |
| [****]                                          |                                          |
|                                            | Analysis                                      | 170$ |
|                                            |                                          |   |
| [****]                                          |                                          |
|                                            | Analysis                                      | 550$ |
|                                            |                                          |   |
| Report****                                      | 688$                                          |
|                                            |                                          |   |
|                                            |                                          |   |
| Sub total for section 1. a.                     | 23,608$                                       |

----

| b. | GMP Amoxicillin trihydrate API analytical release testing |
|----|-----------------------------------------------------------|

| ITEM                                            | Cost (USD$)                                   |
|-------------------------------------------------|-----------------------------------------------|
|                                            |                                          |   |
| ID testing                                      |                                          |
|                                            | IR-Method qualification, set-up and analysis* | 0$ |
|                                            |                                          |   |
| Assay                                           |                                          |
|                                            | Method qualification                          | 2,000$ |
|                                            | Set-up                                        | 605$ |
|                                            | Analysis                                      | 575$ |
|                                            |                                          |   |
| Related substances                              |                                          |
|                                            | Method qualification                          | 2,500$ |
|                                            | Set-up**                                      | 0$ |
|                                            | Analysis                                      | 795$ |
|                                            |                                          |   |
| pH                                              |                                          |
|                                            | Analysis                                      | 85$ |
|                                            |                                          |   |
| Residual solvents                               |                                          |
|                                            | [****]                                        |   |
|                                            | [****]                                        |   |
|                                            | [****]                                        |   |
|                                            | [****]                                        | 30,000$ |
|                                            | [****]                                        | 1,800$ |
|                                            |                                          |   |
| Water - Karl Fisher Titration (USP <921>) |                                          |
|                                            | Analysis                                      | 165$ |
|                                            |                                          |   |
| Appearance                                      |                                          |
|                                            | Analysis                                      | 85$ |
|                                            |                                          |   |
| Crystallinity                                   |                                          |
|                                            | Analysis                                      | 550$ |
|                                            |                                          |   |
| Report****                                      | 1,175$                                        |
|                                            |                                          |   |
|                                            |                                          |   |
| Sub total for section 1. b.                     | 40,335$                                       |

----

| c. | GMP Rifabutin API analytical release testing |
|----|----------------------------------------------|

| ITEM                                            | Cost (USD$)                                   |
|-------------------------------------------------|-----------------------------------------------|
|                                            |                                          |   |
| ID testing                                      |                                          |
|                                            | IR-Method qualification, set-up and analysis* | 0$ |
|                                            | [****]                                        | 575$ |
|                                            |                                          |   |
| Assay                                           |                                          |
|                                            | Method qualification                          | 2,000$ |
|                                            | Set-up                                        | 605$ |
|                                            | Analysis                                      | 575$ |
|                                            |                                          |   |
| Related substances                              |                                          |
|                                            | Method qualification                          | 2,500$ |
|                                            | Set-up**                                      | 0$ |
|                                            | Analysis                                      | 795$ |
|                                            |                                          |   |
| Water - Karl Fisher Titration (USP <921>) |                                          |
|                                            | Analysis                                      | 165$ |
|                                            |                                          |   |
| Limit of N-Iso Butylpiperidone (TLC)            |                                          |
|                                            | Qualification, set-up and analysis            | 1,650$ |
|                                            |                                          |   |
| Residual solvents                               |                                          |
|                                            | [****]                                        |   |
|                                            | [****]                                        |   |
|                                            | [****]                                        | 24,000$ |
|                                            | Analysis                                      | 1,800$ |
|                                            | Qualification [****] ***                      |   |
|                                            |                                          | 2,000$ |
|                                            |                                          |   |
| Appearance                                      |                                          |
|                                            | Analysis                                      | 85$ |
|                                            |                                          |   |
| Report****                                      | 1,103$                                        |
|                                            |                                          |   |
|                                            |                                          |   |
| Sub total for section 1. c.                     | 37,853$                                       |
|                                            |                                          |   |
|                                            |                                          |   |
| Total cost of the amendment                     | 101,795$                                      |

| * | Already included in Service Agreement A. |
|---|------------------------------------------|

| ** | Included in the set-up cost of the Assay. |
|----|-------------------------------------------|

| *** | Analysis to be outsourced to a [****] qualified vendor. [****] in Toronto using the validated analytical methods of [****]. |
|-----|-----------------------------------------------------------------------------------------------------------------------------|

| **** | Cost for the documentation and the CofA- 3% of the total cost of the analysis. |
|------|--------------------------------------------------------------------------------|

----

| 2. | COST AND PAYMENTS |
|----|-------------------|

| 2.1   | The cost of the Services for the Extra Work detailed in section 1 is: |
|-----------------|-----------------------------------------------------------------------|

| 2.1.1   |  $101,795 if the following installments are: |
|-------------------|---------------------------------------------------|

|   | · | 50% at the signature of this Agreement; and |
|--------|--------|---------------------------------------------|

|   | · | the balance at the completion of the release testing. |
|--------|--------|-------------------------------------------------------|

| 2.1.2   | $89,783 if $89,783 is paid within 7 days from the signature of this Agreement. |
|-------------------|--------------------------------------------------------------------------------|

| 2.2   | The Client shall pay to [****] the following installments in United-States currency ($USD): |
|-----------------|--------------------------------------------------------------------------------------------------|

| 3. | TIMELINES FOR AMENDMENT 3 |
|----|---------------------------|

----

| [****]           |   | 7810962 Canada Inc.                |
|------------------|--------|------------------------------------|
| Per:             | /s/    |                               | Per: | /s/ Alain Guimond PhD |   |
| Name: [****]     |   | Name: Alain Guimond PhD            |   |
| Title: President |   | Title: Senior director of Research |   |

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