| 1)  | Contact jnformatlon : |
|----------|---------------------------------|

| 2)  | Work Order Term:    Effective Date: 10-Oct-2013 [****]  |
|----------|--------------------------------------------------------------------------------------------|

| 3)  | The Estimated Central l.aboratorv Budget dated is attached as Attachment #1 and is incorporated herein by reference. |
|----------|-----------------------------------------------------------------------------------------------------------------------------------------------|

| 4)  | Affiliates and Subcontractors: In accordance with the Agreement, the following Quest Diagnostics affiliates and subcontractors shall be utilized for services hereunder: |
|----------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| Affiliate/Subcontractor  Name | Service Provided             |
|-----------------------------------------|------------------------------|
| Quest [****]                            | Testing and related services |
| [****]                                  | Testing and related services |
| [****]                                  | [****]                       |
| [****]                                  | [****]                       |
|                                    |                         |

----

| 5) | Invoices: |
|----|-----------|

|   | Electronic Invoices shall be sent to: | E-mail address: [****] |
|--------|---------------------------------------|------------------------|

|   |   | Attention: [****] |
|--------|--------|-------------------|

|   |   | Phone number: [****] |
|--------|--------|----------------------|

| 6) | Fee Increases.Fees for testing performed at a Quest Diagnostics laboratory shall not increase for the term of this work order. After the conclusion of such term, Quest Diagnostics may increase fees for its Services provided hereunder and annually thereafter to offset any increased costs of operations by providing thirty (30) days written notice to the Client. Any such increase shall not exceed the annual inflation rate during the previous twelve-month period ending on the last day of the month immediately preceding the effective date of the increase, as measured (i) [****] and (ii) in the United States, by the increase in the Consumer Price Index for All Urban Consumers (CPI-U): U. S. City Average, Medical care. |
|----|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| 6) | For this Work Order only the following language shall apply in support of shipping charges to and from the [****]. |
|----|--------------------------------------------------------------------------------------------------------------------|

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|   |  |
|--------|--|

|          |   |   |   |   |   |
|---------------|--------|--------|--------|--------|--------|
|          |   |   |   |   |   |
|          |   |   |   |   |   |
|          |   |   |   |   |   |
| Prepared for: |   | [****] | by:    |   | [****] |
|          |   |   |   |   |   |
|          |   |   |   |   |   |
|          |   |   |   |   |   |
|          |   |   |   |   |   |
|          |   |   |   |   |   |
|          |   |   |   |   |   |
|          |   |   |   |   |   |
| Tel:          |   | [****] | Tel:   |   | [****] |
|          |   |   | Fax:   |   | [****] |
| Email:        |   | [****] | Email: |   | [****] |
|          |   |   |   |   |   |
|          |   |   |   |   |   |
|          |   |   |   |   |   |

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| Regarding:  | Centralized Clinical Laboratory and Related Support Services for Protocol RHB-104-01 (CR) v12 |
|------------------|-----------------------------------------------------------------------------------------------|

|   | · | version 12: Updated patients:visits distribution based on info dated 9-October [****]  |
|--------|--------|---------------------------------------------------------------------------------------------|

----

| RedHillBiopharmaLimited | Quote for Services |  |
|-------------------------|--------------------|--|

----

----

| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Category                                      | Updated Study Value | Previous Study Value * | Difference |
|-----------------------------------------------|---------------------|------------------------|------------|
| Laboratory Testing                            | [****]              | [****]                 | [****]     |
| Supplies                                      | [****]              | [****]                 | [****]     |
| Additional Pass-Through Services              | [****]              | [****]                 | [****]     |
| Study Management                              | [****]              | [****]                 | [****]     |
| Storage & Services                        | [****]              | [****]                 | [****]     |
| Inbound Transportation                        | [****]              | [****]                 | [****]     |
| Batched Inbound                               | [****]              | [****]                 | [****]     |
| Outbound Transportation                       | [****]              | [****]                 | [****]     |
| Outbound Transportation - Shipping Containers | [****]              | [****]                 | [****]     |
| Estimated Central Laboratory Budget:          | [****]              | [****]                 | [****]     |

----

| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Study Duration: | [****] | Total Investigators:  | [****] |   |
|-----------------|--------|-----------------------|--------|--------|
|            |   | Total Countries:      | [****] |   |
|            |   | Total Visits:         | [****] |   |
|            |   | Total Patient-Visits: | [****] |   |

|   | Estimated Grand Total Amount   | [****] |   |
|--------|--------------------------------|--------|--------|
|   | Average Cost Per Patient-Visit | [****] |   |
|   | Average Cost Per Patient       | [****] |   |

| Budget Summary 1               |              |           |            |                   |
|--------------------------------|-------------------|----------------|-----------------|------------------------|
| Sub-Totals                     | Region            | Billing Amount | Conversion Rate | Estimated Total Amount |
|                           | USA, Canada       | [****]         | [****]          | [****]                 |
|                           | Israel            | [****]         | [****]          | [****]                 |
|                           | Study Set-up Fees | [****]         | [****]          | [****]                 |
|                           |              |           |            | [****]                 |
| Average Cost Per Patient-Visit | Region            | [****]         | [****]          | [****]                 |
|                           | USA, Canada       | [****]         | [****]          | [****]                 |
|                           | Israel            | [****]         | [****]          | [****]                 |
|                           | Study Set-up Fees | [****]         |            |                   |
|                           |              | [****]         | [****]          | [****]                 |
| Average Cost Per Patient       | Region            | [****]         | [****]          | [****]                 |
|                           | USA, Canada       | [****]         | [****]          | [****]                 |
|                           | Israel            | [****]         | [****]          | [****]                 |
|                           | Study Set-up Fees | [****]         |            |                   |
|                           |              | [****]         | [****]          | [****]                 |
|                           |              |           |            |                   |

| Detailed Budget Summary           |              |           |            |                   |
|-----------------------------------|-------------------|----------------|-----------------|------------------------|
| Laboratory Testing                | Region            | Billing Amount | Conversion Rate | Estimated Total Amount |
|                              | USA, Canada       | [****]         | [****]          | [****]                 |
|                              | Israel            | [****]         | [****]          | [****]                 |
| [****]                            |              | [****]         |
| Supplies                          | Region            | [****]         | [****]          | [****]                 |
|                              | USA, Canada       | [****]         | [****]          | [****]                 |
|                              | Israel            | [****]         | [****]          | [****]                 |
| [****]                            |              | [****]         |
| Additional Pass-Through Services  | Region            | [****]         | [****]          | [****]                 |
|                              | USA, Canada       | [****]         | [****]          | [****]                 |
|                              | Israel            | [****]         | [****]          | [****]                 |
| [****]                            |              | [****]         |
| Storage                           | Region            | [****]         | [****]          | [****]                 |
|                              | USA, Canada       | [****]         | [****]          | [****]                 |
|                              | Israel            | [****]         | [****]          | [****]                 |
| [****]                            |              | [****]         |
| Study Management                  | Region            | [****]         | [****]          | [****]                 |
|                              | USA, Canada       | [****]         | [****]          | [****]                 |
|                              | Israel            | [****]         | [****]          | [****]                 |
|                              | Study Set-up Fees | [****]         | [****]          | [****]                 |
| [****]                            |              | [****]         |
| Inbound Transportation            | Region            | [****]         | [****]          | [****]                 |
|                              | USA, Canada       | [****]         | [****]          | [****]                 |
|                              | Israel            | [****]         | [****]          | [****]                 |
| [****]                            |              | [****]         |
| Outbound Transportation           | Region            | [****]         | [****]          | [****]                 |
|                              | USA, Canada       | [****]         | [****]          | [****]                 |
|                              | Israel            | [****]         | [****]          | [****]                 |
| [****]                            |              | [****]         |
| Shipping Container Transportation | Region            | [****]         | [****]          | [****]                 |
|                              | USA, Canada       | [****]         | [****]          | [****]                 |
|                              | Israel            | [****]         | [****]          | [****]                 |
| [****]                            |              | [****]         |
|                              |              |           |            |

----

| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Laboratory Testing       | Region      | Time Points | Quantity | BillingCurrencyUnit Price | Billing Amount | Conversion Rate | Estimated Total Amount |
|--------------------------|-------------|-------------|----------|---------------------------|----------------|-----------------|------------------------|
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | USA, Canada | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| [****]                   | Israel      | [****]      | [****]   | [****]                    | [****]         | [****]          | [****]                 |
| Laboratory Testing Total | [****]      |

----

| Supplies       | Region      | Unit   | Quantity | BillingCurrencyUnit Price | BillingAmount | Conversion Rate | Estimated Total Amount |
|----------------|-------------|--------|----------|---------------------------|---------------|-----------------|------------------------|
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | USA, Canada | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]         | Israel      | [****] | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| Supplies Total | [****]      |

----

| Additional Pass-Through Services       | Region      | Unit   | Quantity | BillingCurrencyUnit Price | BillingAmount | Conversion Rate | Estimated Total Amount |
|----------------------------------------|-------------|--------|----------|---------------------------|---------------|-----------------|------------------------|
| [****]                                 | USA, Canada |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | USA, Canada |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | USA, Canada |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | USA, Canada |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | USA, Canada |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | USA, Canada |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | USA, Canada |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | USA, Canada |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | USA, Canada |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | USA, Canada |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | USA, Canada |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | USA, Canada |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | Israel      |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | Israel      |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | Israel      |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | Israel      |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | Israel      |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | Israel      |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                 | Israel      |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| Additional Pass-Through Services Total | [****]      |

| Storage | Region      | Aliquots | Quantity | BillingCurrencyUnit Price | BillingAmount | Conversion Rate | Estimated Total Amount |
|---------|-------------|----------|----------|---------------------------|---------------|-----------------|------------------------|
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]  | USA, Canada | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |

----

| Storage       | Region | Aliquots | Quantity | BillingCurrencyUnit Price | BillingAmount | Conversion Rate | Estimated Total Amount |
|---------------|--------|----------|----------|---------------------------|---------------|-----------------|------------------------|
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]        | Israel | [****]   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| Storage Total |   | [****]   |

----

| Study Management                        | Region            | Unit   | Quantity | BillingCurrencyUnit Price | BillingAmount | Conversion Rate | Estimated Total Amount |
|-----------------------------------------|-------------------|--------|----------|---------------------------|---------------|-----------------|------------------------|
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Study Set-up Fees |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Study Set-up Fees |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Study Set-up Fees |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Study Set-up Fees |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| Study Management Total                  | [****]            |
| Inbound Transportation                  | Region            | Unit   | Quantity | BillingCurrencyUnit Price | BillingAmount | Conversion Rate | Estimated Total Amount |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| Inbound Transportation Total            | [****]            |
| Outbound Transportation                 | Region            | Unit   | Quantity | BillingCurrencyUnit Price | BillingAmount | Conversion Rate | Estimated Total Amount |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| Outbound Transportation Total           | [****]            |
| Shipping Container Transportation       | Region            | Unit   | Quantity | BillingCurrencyUnit Price | BillingAmount | Conversion Rate | Estimated Total Amount |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | USA, Canada       |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| [****]                                  | Israel            |   | [****]   | [****]                    | [****]        | [****]          | [****]                 |
| Shipping Container Transportation Total | [****]            |

----

| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Category | Name   | Screening   | Baseline | V2     | V3     | V4     | V5     | V6     | V7     | V8     |
|----------|--------|-----------------------|----------|--------|--------|--------|--------|--------|--------|--------|
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]   | [****] | [****]                | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |

----

| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Category   | Name   | Screening | Baseline | V2     | V3     | V4     | V5     | V6     | V7     | V8     |
|----------------------|--------|-----------|----------|--------|--------|--------|--------|--------|--------|--------|
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |

----

| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Category   | Name   | Screening | Baseline | V2     | V3     | V4     | V5     | V6     | V7     | V8     |
|----------------------|--------|-----------|----------|--------|--------|--------|--------|--------|--------|--------|
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |

----

| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Category   |   | Screening | Baseline | V2     | V3     | V4     | V5     | V6     | V7     | V8     |
|----------------------|--------|-----------|----------|--------|--------|--------|--------|--------|--------|--------|
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| [****]               | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                 | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] |

----

| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Category | Name   | V9     | V10    | V11    | V12    | V13    | V14    | Biopsy     | Sample                     | Sample               | Susceptibility |
|----------|--------|--------|--------|--------|--------|--------|--------|------------|----------------------------|----------------------|----------------|
|     |   |   |   |   |   |   |   | Processing | processing                 | processing           | Testing        |
|     |   |   |   |   |   |   |   | ([****])   |  – [****] tubes | – [****] tubes | ([****])       |
|     |   |   |   |   |   |   |   |       | ([****])                   | ([****])             |           |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]                     | [****]               | [****]         |

----

| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Category | Name   | V9     | V10    | V11    | V12    | V13    | V14    | Biopsy     | Sample               | Sample               | Susceptibility |
|----------|--------|--------|--------|--------|--------|--------|--------|------------|----------------------|----------------------|----------------|
|     |   |   |   |   |   |   |   | Processing | processing           | processing           | Testing        |
|     |   |   |   |   |   |   |   | ([****])   | – [****] tubes | – [****] tubes | ([****])       |
|     |   |   |   |   |   |   |   |       | ([****])             | ([****])             |           |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |

----

| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Category | Name   | V9     | V10    | V11    | V12    | V13    | V14    | Biopsy     | Sample               | Sample               | Susceptibility |
|----------|--------|--------|--------|--------|--------|--------|--------|------------|----------------------|----------------------|----------------|
|     |   |   |   |   |   |   |   | Processing | processing           | processing           | Testing        |
|     |   |   |   |   |   |   |   | ([****])   | – [****] tubes | – [****] tubes | ([****])       |
|     |   |   |   |   |   |   |   |       | ([****])             | ([****])             |           |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |

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| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Category |   | V9     | V10    | V11    | V12    | V13    | V14    | Biopsy     | Sample               | Sample               | Susceptibility |
|----------|--------|--------|--------|--------|--------|--------|--------|------------|----------------------|----------------------|----------------|
|     |   |   |   |   |   |   |   | Processing | processing           | processing           | Testing        |
|     |   |   |   |   |   |   |   | ([****])   | – [****] tubes | – [****] tubes | ([****])       |
|     |   |   |   |   |   |   |   |       | ([****])             | ([****])             |           |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
| [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |
|     | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |

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| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Country       | Sites  | Screening | Baseline | V2     | V3     | V4     | V5     | V6     | V7     | V8     | V9     | V10    | V11    | V12    |
|-------------------------|--------|-----------|----------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|--------|
| Calculated Totals:      | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
|                    |   |      |     |   |   |   |   |   |   |   |   |   |   |   |
| Canada(Toronto)         | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| United States(New York) | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] |
| Israel(Tel Aviv)        | [****] | [****]    | [****]   | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] | [****] |

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| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Country                 | Sites  | V13    | V14    | Biopsy     | Sample               | Sample               | Susceptibility |   |
|-------------------------|--------|--------|--------|------------|----------------------|----------------------|----------------|--------|
|                    |   |   |   | Processing | processing           | processing           | Testing        |   |
|                    |   |   |   | ([****])   | – [****] tubes | – [****] tubes | ([****])       |   |
|                    |   |   |   |       | ([****])             | ([****])             |           |   |
| Calculated Totals:      | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |   |
|                    |   |   |   |       |                 |                 |           |   |
| Canada(Toronto)         | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |   |
| United States(New York) | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |   |
| Israel(Tel Aviv)        | [****] | [****] | [****] | [****]     | [****]               | [****]               | [****]         |   |

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| RedHill Biopharma Limited | Quote for Services |  |
|---------------------------|--------------------|--|

| Global Summary                           |
|------------------------------------------|
| 1                                        |   | See Study Specific Assumptions and Pricing Model, herein.  Budget excludes any “TBD” (To Be Determined) items. |
| Global Summary - Laboratory Testing (LT) |
| 1LT                                      |   | Quoted fees reflect Quest Diagnostics Clinical Trials’ Year 2011 Fee Schedule. |
| 2LT                                      |   | Referral test to be performed by UCF. Fee includes the referral laboratory charge plus a referral fee for sample handling, data entry and result reporting. Any fee increase imposed by the Referral laboratory will be passed on to Client. |
| 3LT                                      |   | Fees quoted for testing services performed are exclusive of any applicable added Taxes (including Value Added Tax (VAT)). |
| 4LT                                      |   | The sample testing fees include the receipt of samples into a Quest Diagnostics-owned, affiliate or alliance partner laboratory, the direct costs associated with the laboratory testing of the samples, retention of the unused samples for a maximum of fourteen (14) days, laboratory quality control and global standardisation of equipment, processes, controls and calibrators. |
| 5LT                                      |   | The sample testing fees also include the distribution of interim result reports (per patient visit) and final result reports to Investigator(s) and/or Clients/CROs as applicable and agreed in the Central Laboratory Worksheet.  Any final result reports issued in hard copy will be sent via standard postal service or (within the continental United States only) Quest Diagnostics-US proprietary courier. |
| 6LT                                      |   | It is Quest Diagnostics Clinical Trials' (Quest) experience that  investigator sites experience significant challenges producing a peripheral blood smear ( PBS )  of sufficient quality for an appropriate hematology laboratory PBS review. Therefore, it is standard Quest practice to not provide glass slides and to not require the sites to make PBS slides . The performance by Quest of a routine safety CBC analysis (hematology) does involve the occasional review of PBS slides for the white blood cell morphology and differential, red blood cell morphology and platelet evaluation if the instrument or the SOP flags the specimen for a PBS slide review. The PBS slide can be appropriately created and reviewed in the majority of cases by the laboratory from the submitted CBC sample if a review is required.  |
| 7LT                                      |   | If the protocol requires a PBS slide review then glass microscope slides will be provided to the site(s) for each appropriate visit so that the site can create and provide a PBS to the central laboratory. Protocols where in our experience peripheral blood smears are recommended include significant hematological/bone marrow abnormalities (white or red cell, platelet abnormalities), leukaemia's, HIV clinical trials, sepsis, or other severe illnesses that would be impacting the hematological system. Our scientific affairs and medical affairs teams are available to further discuss the needs of your protocol regarding any requirements for PBS creation by the site or by the laboratory and PBS slide review by the Quest laboratory. Please could you confirm if this protocol requires a peripheral blood smear review or if subjects in this study are expected  to have hematological abnormalities where we would recommend the preparation of peripheral blood smears at the investigator site. |
| 8LT                                      |   | CBC and Peripheral blood smear pricing are based on assumptions received at the point of preparing this quotation.  Quest Diagnostics reserves the right to adjust these pertinent to further discussion with the customer. |
| Global Summary - Supplies (SL)           |
| *                                        |   | The Supplies total for shipping containers is based on one separate shipment for each patient visit and reflects a “worst case scenario.”  Shipper container costs may be dramatically reduced when sites batch specimens prior to shipment to the laboratory. |
| 1SL                                      |   | Quest Diagnostics Clinical Trials will determine the price for a 40+ Visit Specific Kit(VSP) once all tubes and details of kit components have been finalized with the sponsor. |
| Global Summary - Supplies (ST)           |
| 1ST                                      |   | The “In” fee includes receipt, preparation, storage and entry of specimens into Quest Diagnostics Clinical Trials storage facility and computer system. |
| 2ST                                      |   | The “Monthly Maintenance” fee includes inventory, storage, temperature monitoring and continuous security coverage at Quest Diagnostics Clinical Trials storage facility. |
| 3ST                                      |   | The “Pull” fee includes the removal of requested specimens from storage, sorting of specimens prior to shipment (in a manner requested by client, e.g. - by patient, by visit) and the generation of a manifest. |
| Global Summary - Study Management (SM)   |
| 1SM                                      |   | The Study Management set-up fees quoted include provision for our standard toxicity and exclusions flagging; and cumulative data transmissions sent weekly via email zip file or SFTP or portals in our standard data file format. The fees do not include any set-up related to storage samples, new testing method set-up's, algorithms, microbiology testing or referral lab data entry. If client requires Quest to add any of these elements or set up additional flagging options and use data files which differ to our standard format, we reserve the right to adjust our set-up fees accordingly. |
| 2SM                                      |   | The Project Management Study Set-Up fee includes an internal review of the protocol in conjunction with the client's study team and formulation of an agreed Central Laboratory Worksheet signed off by Client and Quest, which lays out detailed specifications for the set-up and management of the study. Quest will design study documents, which include Investigator Manuals in the languages specified in the budget, a Lab Requirement Summary and pictogram, and study specific test Requistion forms in accordance with these specifications, as part of this fee. The design of visit specific specimen collection kits and set-up of Investigator site information is included as part of Project Management set-up. |
| 3SM                                      |   | The fee Per Visit for Project Management covers ongoing Project Management support, 24/7 investigator assistance/support by Quest Diagnostics CRC Support Team, including the use of toll-free phone lines.  Auto faxing of supply expiry details and inclusion of alerts and delta flagging are also covered by this fee. |
| 4SM                                      |   | The fee Per Visit for Data Management covers ongoing Data Management support, maintenance of the results database and the actioning and documentation of all necessary data revisions and data transfers up to once per week. |
| 5SM                                      |   | The fee Per Visit for Logistics covers the expertise and management of the ongoing study logistics, shipment tracking, processing and auditing of courier invoices and the performance management of the courier companies. |
| 6SM                                      |   | Quest Diagnostics proprietary software Result/ViewTM – web-based version shall be included for the two users per study at no additional charge, more than two users will be charged. This includes training and support by telephone. |
| 7SM                                      |   | Quest Diagnostics Clinical Trials will charge a per work order fee associated with each pull order. The purpose of this is to maximize the batching of samples whenever they are pulled for regular or ad hoc shipments from sample storage in order to create operational efficiency. |

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| Global Summary - Inbound Transportation (IT)       |
|----------------------------------------------------|
| **                                                 |   | The Inbound Transportation total is representative of individual patient specimen shipments and reflects a “worst case scenario”.  Transportation totals may be dramatically reduced when sites batch specimens prior to shipment to the laboratory. |
| 1IT                                                |   | The inbound specimen transportation fees are based on typical volumetric weight, and vary by city.  Quest Diagnostics Clinical Trials will bill client actual transport costs, per the invoice of the transport company. Any change to the fee imposed by the courier will be passed on to client. Additional charges for secondary cities, holidays and weekend service may apply. |
| 2IT                                                |   | The USD ($) Inbound Diagnostic Transportation fees quoted are based on an estimated exchange rate of £1 GBP = $ 1.6022. However, all Inbound Diagnostic Transportation will be billed at the actual £GBP to USD ($) rate ruling in the applicable month as published by UK Customs and Excise. Thus the Inbound Transportation fees may vary from those quoted in this budget in any given month depending on what the actual exchange rate is. |
| 3IT                                                |   | The Logistics estimates included represent our best recommendations based on recent experience.  We welcome the opportunity to discuss carrier performance and recommendations since the decision on courier selection ultimately resides with the sponsor. |
| Global Summary - Outbound Transportation (OT) |
| 1OT                                                |   | Initial Supply Shipments: Initial shipments will be distributed within ten (10) working days from Client’s approval of the (a) requisition form, (b) Investigator Manual, and (c) receipt of Client’s final Investigator list. Quest Diagnostics’ must also receive Client’s approval of Quest Diagnostics’ verification report (without changes) at least 2 days prior to shipment. |
| 2OT                                                |   | Please note that Quest Diagnostics Clinical Trials does charge an additional fee for expedited/priority starter pack shipments. |
| 3OT                                                |   | Shipment of Re-supplies: Re-supply orders will be distributed within five (5) working days of Quest Diagnostics’ receipt of the Request for Supplies form from the Investigator or Client. Any re-supply orders containing special supplies shall be shipped upon supply availability and may require more than a five (5) working day turnaround. |
| 4OT                                                |   | Quest Diagnostics will use commercially-reasonable efforts to provide re-supply orders with less than five (5) working-days prior notification from Client or the Investigator (“STAT re-orders”).  However, Client will be responsible for all additional labor and transportation charges associated with STAT re-orders. |
| 5OT                                                |   | The Outbound transportation fees are based on typical volumetric weight.  Quest Diagnostics Clinical Trials will bill client actual transport costs per the invoice of the transport company.  Any change to the fee imposed by the courier will be passed on to client.  Priority shipments, e.g. next-day air are additional.  Fees for outbound supply shipments do not include any imposed tariffs. |
| 6OT                                                |   | The USD ($) Outbound transportation fees quoted are based on an estimated exchange rate of £1 GBP = $ 1.6022. However, all Outbound Transportation will be billed at the actual £GBP to USD ($) rate ruling in the applicable month as published by UK Customs and Excise. Thus the actual Outbound Transportation fees may vary from those quoted in this budget in any given month depending on what the actual exchange rate is. |
| 7OT                                                |   | The Logistics estimates included represent our best recommendations based on recent experience.  We welcome the opportunity to discuss carrier performance and recommendations since the decision on courier selection ultimately resides with the sponsor. |

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