|   | (1) | Definitions |
|--------|-----|-------------|

----

|   | (2) | Services. |
|--------|-----|-----------|

|   | (a) | The Services covered by this Agreement may include strategic planning, expert consultation, clinical trial services, statistical programming and analysis, data processing, data management, regulatory, clerical, project management, central laboratory services, preclinical services, pharmaceutical sciences services, medical device services, electronic data capture and other research and development services requested by REDHILL. Each time REDHILL wants to engage Clinipace to provide Services, a detailed description of the Services will be described in one or more statements of work (each an “Attachment”) to be executed by the parties pursuant to this Agreement  (“Attachment A-1, A-2, A-3 and so on”), which will be attached hereto and incorporated herein.  The specific terms and conditions of each engagement will be delineated in the applicable Attachment, which shall be sequentially numbered and incorporated herein by reference.  In the event of any conflict between the terms of this Agreement and in any Attachment, the terms of the Attachment shall prevail.  For the avoidance of doubt, the mere signature of this Agreement does not result in any obligation on behalf of REDHILL to engage Clinipace to provide any Services. |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (b) | Once the parties have agreed on the terms and conditions of an Attachment, the following shall apply to any Change Order. Any (a) meaningful change in the details of the scope of Services, even if a fixed price Attachment, or (b) meaningful change in the assumptions upon which the Attachment is based may require changes in the budget and/or time lines, and shall require a written amendment to the scope of Services (a "Change Order"). For the avoidance of doubt, any Change Order has to originate from a quantifiable change of scope of the study. A delay in study initiation will not be considered a change to the study's scope so long as Clinipace’s provision of Services has not begun. Each Change Order shall detail the requested changes to the applicable task, responsibility, duty, budget, time line or other matter.  The Change Order will become effective upon the execution of the Change Order by both parties, and will include a specified period of time (as agreed upon by the parties) within which Clinipace will implement the changes.  Both parties agree to act in good faith and promptly when considering a Change Order requested by the other party. Clinipace reserves the right to postpone effecting material changes in the Project's scope until such time as the parties agree to and execute the corresponding Change Order.  For any Change Order that affects the scope of the regulatory obligations that have been transferred to Clinipace, if any, Clinipace and REDHILL shall execute a corresponding amendment to any form documenting the transfer of regulatory responsibilities as described in 21 CFR 312.52. REDHILL shall provide all appropriate changes on the FDA 1571 form (Investigational New Drug Application) and will file such amendment where appropriate, or as required by law or regulation. |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | (3) | Term. |
|--------|-----|-------|

|   | (4)  | Fees. |
|--------|-----------|-------|

|   | (c)  | REDHILL will remit invoice payments via Wire.  Wire instructions will be included on A-1, A-2, A-3, etc. |
|--------|-----------|--------------------------------------------------------------------------------------------------------------------|

----

|   | (5)  | Confidentiality. |
|--------|-----------|------------------|

|   | (6) | Publication. |
|--------|-----|--------------|

----

|   | (7)  | Representations and Warranties. |
|--------|-----------|---------------------------------|

|   | (8)  | REDHILL Responsibilities. |
|--------|-----------|---------------------------|

|   | (a) | REDHILL shall forward to CLINIPACE in a timely manner all documents, materials and information in REDHILL's possession or control necessary for CLINIPACE to conduct the Services.  CLINIPACE shall not be liable to REDHILL nor be deemed to have breached this Agreement or any Work Order for errors, delays or other consequences arising from REDHILL's failure to timely provide documents, materials or information or to otherwise cooperate with CLINIPACE in order for CLINIPACE to timely and properly perform its obligations.  So long as Services have not begun, and the scope of the study or the scope of work undertaken by Clinipace is not increased, in the event that the FDA or similar applicable regulatory or governmental authority requires REDHILL to delay or postpone the study or any particular module therein, then REDHILL will be entitled to postpone the initiation of the study or any particular module therein without this having an impact on the fees and without requiring a Change Order. Clinipace will inform RedHill in advance of incurring any expenses which are non-cancelable.: If REDHILL delays a project after the initiation of the performance of any Services from its agreed starting date or suspends performance of a project for a period longer than ten (10) working days, then either: a) REDHILL will pay the standard daily rate of the CLINIPACE's personnel assigned to the project, based on the percentage of their time allocated to the project, for the period of the delay beginning on the eleventh working day, in order to keep the current team members; or, b) CLINIPACE may re-allocate the personnel at its discretion, and REDHILL will pay the costs of retraining new personnel. In addition, REDHILL will pay all non-cancelable costs and expenses incurred by CLINIPACE due to the delay and will adjust all timelines to reflect additional time required due to the delay. |
|--------|-----|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | (b) | REDHILL warrants and represents that it has the full right and authority to enter into this Agreement, and will comply with all applicable laws and regulations as it relates to the Services contemplated herein.  REDHILL shall provide CLINIPACE with all information available to it regarding known or potential hazards associated with the use of any substances supplied to CLINIPACE by REDHILL, and REDHILL shall comply with all current legislation and regulations concerning the shipment of substances by the land, sea or air. |
|--------|-----|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

|   | (9)  | Property Rights. |
|--------|-----------|------------------|

|   | (10)  | Indemnity Agreement. |
|--------|------------|----------------------|

----

|   | (11)  | Disclaimer and Limitation of Liability |
|--------|------------|----------------------------------------|

|   | (12)  | Assignments. |
|--------|------------|--------------|

|   | (13)  | Relationship and Status. |
|--------|------------|--------------------------|

----

|   | (14)  | Insurance. |
|--------|------------|------------|

|   | (15)  | Termination. |
|--------|------------|--------------|

----

|   | (16)  | Survival Provision. |
|--------|------------|---------------------|

|   | (17) | Notices. |
|--------|------|----------|

|   | Any notice required or permitted to be given hereunder by either party thereunder shall be in writing and shall be deemed given on the date received if delivered personally or by a reputable overnight delivery service, or three (3) days after the date postmarked if sent by registered or certified mail, return receipt requested, postage prepaid to the following addresses: |
|--------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| If to Clinipace                                                                                                            | If to REDHILL:                                                                                                                    |
|----------------------------------------------------------------------------------------------------------------------------|-----------------------------------------------------------------------------------------------------------------------------------|
|                                                                                                                       |                                                                                                                              |
| Clinipace, Inc.RedHill Biopharma LTD3800 Paramount Parkway, Suite 100Morrisville, NC 27560 USA Attention: _________ Title: | RedHill Biopharma LTD21 Ha’arba’a St64739 Tel-AvivAttention: Gilead RadayTitle: VP Corporate &Product Development |

----

|   | (16) | Additional Terms |
|--------|------|------------------|

| (a)   | Unless explicitly stated herein, REDHILL is solely responsible for the conduct of the Studies, and CLINIPACE shall provide various Services defined herein to support REDHILL in the conduct of the Studies. |
|-----------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (b)   | CLINIPACE shall conduct the Services as outlined herein, and in accordance to the protocol of each Trial, and in accordance with all applicable laws and regulations. |
|-----------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (c)   | CLINIPACE agrees that for the duration of this Agreement, that it shall notify REDHILL in a timely fashion when CLINIPACE receives information regarding any serious adverse events related to the product use in the Study(s). |
|-----------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (d)   | CLINIPACE shall report to REDHILL any investigator that is not complying with his/her agreement with REDHILL. |
|-----------------|---------------------------------------------------------------------------------------------------------------|

| (e)   | CLINIPACE shall permit REDHILL’s representatives to perform, during normal business hours and with reasonable notice and without undue interruption, quality assurance audits of the work performed under this Agreement to assure the Services are being performed in accordance with the applicable protocol(s) and this Agreement.  CLINIPACE shall promptly correct any errors or deficiencies discovered during an audit. |
|-----------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

| (f)   | REDHILL shall provide a Project Manager who shall be the primary contact with CLINIPACE. |
|-----------------|------------------------------------------------------------------------------------------|

| (g)   | Data shall be collected on the web-based Tempo platform, and entered by clinical site staff, REDHILL Staff or REDHILL coordinators. |
|-----------------|-------------------------------------------------------------------------------------------------------------------------------------|

| (h)   | CLINIPACE and REDHILL shall work in good faith to establish relevant CLINIPACE SOPs, which shall govern the Study. |
|-----------------|--------------------------------------------------------------------------------------------------------------------|

| (i)   | All clinical data collected during and related to the Study are the property of REDHILL, and CLINIPACE retains no rights whatsoever in such clinical data. |
|-----------------|------------------------------------------------------------------------------------------------------------------------------------------------------------|

----

|   | (17)  | Miscellaneous Provisions. |
|--------|------------|---------------------------|

----

| REDHILL, Inc.:   |   |   |   |   |
|------------------|--------|--------|--------|--------|
|             |   |   |   |   |   |
|             |   |   |   |   |   |
| By:              | /s/    |   | Date:  |   |   |
|             |   |   |   |   |   |
| Name:            |   |   |   |   |   |
|             |   |   |   |   |   |
| Title:           |   |   |   |   |   |
|             |   |   |   |   |   |
|             |   |   |   |   |   |
| CLINIPACE, INC.: |   |   |   |   |
|             |   |   |   |   |   |
|             |   |   |   |   |   |
| By:              | /s/    |   | Date:  |   |   |
|             |   |   |   |   |   |
| Name:            |   |   |   |   |   |
|             |   |   |   |   |   |
| Title:           |   |   |   |   |   |

----

| Patient Specifications            |                                                     |
|-----------------------------------|----------------------------------------------------------|
|                              | Number of Patients Screened                              | [****] |
|                              | Number of Patients Enrolled                              | [****] |
|                              | Number of Patients Complete                              | [****] |
|                              | Estimated Number of Serious Adverse Events (per subject) | [****] |
| Site Specifications               |                                                     |
|                              | Number of Sites Identified                               | 8.0 |
|                              | Number of Qualification Visits                           | 8.0 |
|                              | Qualification Visit (duration in days)                   | 0.5 |
|                              | Number of Initiation Visits                              | 8.0 |
|                              | Initiation Visit (duration in days)                      | 1.0 |
|                              | Number of Interim Monitoring Visits per Site             | 3.4 |
|                              | Total number of Interim Monitoring Visits                | 27.0 |
|                              | Interim Monitoring Visit (duration in days)              | 1.0 |
|                              | Number of Close-out Visits                               | 8.0 |
|                              | Close-out Visit (duration in days)                       | 1.0 |
| CRF Specifications                |                                                     |
|                              | Estimated Unique Pages                                   | 15.0 |
|                              | Estimated Total Pages per Patient                        | 30.0 |
| Project Management Specifications |                                                     |
|                              | Number of Kick-off Meetings                              | 1.0 |
|                              | Kick-off Meeting (duration in days)                      | 4.0 |
|                              | Number of Client Project Meetings (face-to-face)         | 1.0 |
|                              | Number of Client/Clinipace Teleconferences (0.5 hours)   | 22 |
|                              | Number of Internal Meetings                              | 11.0 |
| SAEs                              |                                                     |
|                              | Number of SAEs                                           | [****] |
|                              | Number of Reportable SAEs                                | [****] |
| Statistical Analysis              |                                                     |
|                              | Number of TLF displays                                   | 31 |

----

| Milestone                                                           | Estimated Date |                   |
|---------------------------------------------------------------------|----------------|------------------------|
| CPWW Activities Begin                                               | [****]         | Pre-Study Activities   |
| Final Protocol/ICF                                                  | [****]         |                   |
| IND Submission                                                      | [****]         |                   |
| Start-up Period Begins                                              | [****]         |                   |
| Start-up Period Ends                                                | [****]         |                   |
| Initiation of study activities (upon written confirmation from RHB) | [****]         | Study Activities       |
| Enrollment Ends                                                     | [****]         |                   |
| Treatment Period Ends                                               | [****]         |                   |
| Collection of Final CRFs                                            | [****]         |                   |
| Query Resolution                                                    | [****]         |                   |
| Database Lock                                                       | [****]         |                   |
| Statistical Analysis                                                | [****]         | Post Dosing Activities |
| Draft Report                                                        | [****]         |                   |
| Final Report                                                        | [****]         |                   |
| CPWW Activities End                                                 | [****]         |                   |

| Project-specific Tasks                     | Responsibility |
|--------------------------------------------|----------------|
|                                       | N/A            | RedHill | CPWW | Joint |
| Clinical Trial Preparation                 |
| Investigator Brochure Development          |           |   | ý |   |
| Protocol/Protocol amendment                |           | ý |   |   |
| eCRF Preparation                           |           |   | ý |   |
| Informed Consent Template Preparation      |           |   | ý |   |
| Site-Specific Informed Consent Form Review |           |   | ý |   |
| Central IRB Selection and Management       |           |   | ý |   |
| Monitoring Plan Development                |           |   | ý |   |

----

| Collection of Site Regulatory Documents (Including site IRB)                                               |   |   | ý |   |
|------------------------------------------------------------------------------------------------------------|--------|--------|--------|--------|
| Regulatory Binders to sites                                                                                |   |   | ý |   |
| Regulatory Authority Submission                                                                            |   |   | ý |   |
| Site selection                                                                                             |   |   |   | ý |
| Central Laboratory Selection (If needed)                                                                   |   |   | ý |   |
| Central Laboratory Management and Payment                                                                  |   |   | ý |   |
| Investigator’s Grant Negotiation                                                                     |   |   |   | ý |
| Training materials                                                                                         |   |   |   | ý |
| Project Kick-off Meeting                                                                                   |   |   |   | ý |
| Investigator’s Study Files Structures                                                                |   |   | ý |   |
| CTM Packaging, Labeling and Distribution                                                                   |   | ý |   |   |
| Monitoring and Trial Management                                                                            |
| Pre-Study visits                                                                                           |   |   | ý |   |
| Site Initiation Visits                                                                                     |   |   | ý |   |
| Periodic Site Visits (Every 6 to 8 weeks)                                                                  |   |   | ý |   |
| Site Close-out Visits                                                                                      |   |   | ý |   |
| Enrollment Status Reports                                                                                  |   |   | ý |   |
| SAE reports                                                                                                |   |   | ý |   |
| Contact Reports                                                                                            |   |   | ý |   |
| Site Management                                                                                            |   |   | ý |   |
| Study Reference Manual                                                                                     |   |   | ý |   |
| Project Management                                                                                         |   |   |   |   |
| Maintenance of Study Master File                                                                           |   |   | ý |   |
| Schedule Client Meeting / Prepare Minutes                                                                  |   |   | ý |   |
| Study Timelines                                                                                            |   |   |   | ý |
| Medical Monitoring                                                                                         |
| Medical Monitoring                                                                                         |   |   | ý |   |
| Medical Review                                                                                             |   |   | ý |   |
| Data Safety Monitoring Board Selection                                                                     |   |   | ý |   |
| Data Safety Monitoring Board Management & Meetings                                                     |   |   | ý |   |
| Pharmacovigilance                                                                                          |
| Serious Adverse Event Management                                                                           |   |   | ý |   |
| Regulatory Submission of Adverse Event Reports                                                             |   |   | ý |   |
| Data Management & Biostatistics                                                                        |
| Database Design Set-up/Modification (included in eCRF design) Refer to Appendix III for Schedule of Events |   |   | ý |   |
| Data Management Plan                                                                                       |   |   | ý |   |
| Data Coding, AEs, Medications                                                                              |   |   | ý |   |
| Central Laboratory Data Transfer                                                                           |   |   | ý |   |
| Randomization Scheme                                                                                       |   |   | ý |   |
| Statistical Analysis Plan                                                                                  |   |   | ý |   |
| Prepare Study Tables, Listings and Figures                                                                 |   |   | ý |   |
| Clinical Study Reports                                                                                     |
| Provide 2 draft study reports                                                                              |   |   | ý |   |
| Provide 2 Final Study Reports                                                                              |   |   | ý |   |
| Publishing                                                                                                 |   | ý |   |   |
| Quality Assurance                                                                                          |
| GCP Site Audits                                                                                            |   | ý |   |   |
| QC Audits of CSRs                                                                                          |   |   | ý |   |
| QC Audit of Database                                                                                       |   |   | ý |   |

----

| Task                                      | Assumptions                                                                                                                                                                                                                        | Hours  | Total (US$) |
|-------------------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|-------------|
| PROTOCOL DEVELOPMENT AND AMENDMENTS       |                                                                                                                                                                                                                               |   | $ [****]    |
| Protocol Development                      | Clinipace will review the protocol developed by RedHill Biopharma Ltd. . The estimate is based on two review cycles ( administrative changes are not limited to two review cycles)                                                 | 16     | $ [****]    |
| Protocol Amendment(s)                     | Clinipace will review protocol amendment(s) during the course of this study. We have estimated 1 amendment(s) to the protocol. (Administrative changes/corrections not limited to 1 amendment)                                     | 5      | $ [****]    |
| REVIEW STUDY MATERIALS                    |                                                                                                                                                                                                                               |   | $[****]     |
| Review Study Materials                    | General review of study materials by Clinipace Project Team.                                                                                                                                                                       | 28     | $ [****]    |
| PROTOCOL DISTRIBUTION AND TRANSLATION     |                                                                                                                                                                                                                               |   | $[****]     |
| Distribute Protocol to Sites              | Includes IB                                                                                                                                                                                                                        | 8      | $ [****]    |
| Distribute Protocol Amendment(s) to Sites | Based on 1 amendment(s).                                                                                                                                                                                                           | 8      | $ [****]    |
| Protocol Translation                      | Translations will be handled by third party vendors. Includes time to manage the vendors.                                                                                                                                          | 9      | $ [****]    |
| eCRF DEVELOPMENT                          |                                                                                                                                                                                                                               |   | $[****]     |
| Develop eCRF                              |                                                                                                                                                                                                                               | 68     | $ [****]    |
| eCRF Completion Guidelines                | Clinipace will create the eCRF Completion Guidelines.                                                                                                                                                                              | 11.25  | $ [****]    |
| INFORMED CONSENT                          |                                                                                                                                                                                                                               |   | $ [****]    |
| Develop Informed Consent Form (ICF)       | Clinipace will develop the model ICF. RedHill Biopharma Ltd. will review and approve the consent. Based on 1 review cycle.                                                                                                         | 22     | $ [****]    |
| Negotiate changes to template with sites  | Clinipace will work with the site(s) on any local changes to the ICF. Clinipace will consult RedHill Biopharma Ltd. on any changes from the site(s).                                                                               | 24     | $ [****]    |
| Update ICF - Protocol Amendments          | Clinipace will be responsible for updating the ICF based on amendments to the protocol. Based on 1 amendment(s).                                                                                                                   | 16     | $ [****]    |
| Translation of Informed Consent           | Clinipace will work with the sites to translate the Informed Consent into the appropriate language.                                                                                                                                | 8      | $ [****]    |
| INVESTIGATOR SELECTION/PRE-STUDY VISITS   |                                                                                                                                                                                                                               |   | $ [****]    |
| Develop Site Recruitment Materials        |                                                                                                                                                                                                                               | 8      | $ [****]    |
| Identify and Recruit Investigators        | Clinipace will work to identify 8 investigators willing and able to participate in this trial. Clinipace will provide Sponsor with a list of sites for approval. We have estimated we will need to identify [****] sites to get 8. | [****] | $ [****]    |

----

| Perform Pre-Study Site Visits - US                                                                | 4 hours on site, avg. 8 hours travel RT, 6 hours prep and reporting = 18 hours.                                                                                                                                                                            | [****] | $ [****] |
|---------------------------------------------------------------------------------------------------|------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|----------|
| CLINICAL TRIAL AGREEMENTS                                                                         |                                                                                                                                                                                                                                                       |   | $ [****] |
| Negotiate contracts with sites                                                                    | Clinipace will negotiate and hold site contracts and budgets with each site.                                                                                                                                                                               | 40     | $ [****] |
| Investigator Grants                                                                               | Clinipace will administer payments to each site. This proposal is based on quarterly payments per site.                                                                                                                                                    | 9.6    | $ [****] |
| REGULATORY DOCUMENTS                                                                              |                                                                                                                                                                                                                                                       |   | $ [****] |
| Prepare, collect, review appropriate regulatory documents                                         | Clinipace will provide templates to each site including Financial Disclosure Document and 1572, then collect locally required approval documents. This line includes communication with sites to obtain final documents and corrections. Based on 8 sites. | 80     | $ [****] |
| Regulatory Binder                                                                                 | Each site will receive a regulatory binder that contains all required documents. This binder will be checked at each monitoring visit.                                                                                                                     | 24     | $ [****] |
| Study Procedures Manual                                                                           | A study procedures manual will be prepared and distributed to each site. This manual will contain information on lab shipping, monitoring plans, etc.                                                                                                      | 24     | $ [****] |
| Prepare study aids such as drug logs, etc.                                                        |                                                                                                                                                                                                                                                       | 24     | $ [****] |
| Prepare and submit package to sites for submission to ethics committees.                          |                                                                                                                                                                                                                                                       | 8      | $ [****] |
| Update documentation for IRBs/ECs - Protocol Amendment(s)                                         | Based on 1 amendment(s).                                                                                                                                                                                                                                   | 8      | $ [****] |
| Prepare and submit dossier for submission to appropriate Ministry of Health, Track MoH approvals. | RedHill will be responsible for regulatory authority submissions.                                                                                                                                                                                          | 0      | $ [****] |
| Communication and preparation of official responses to MoH pending issues.                        | RedHill will be responsible for regulatory authority submissions.                                                                                                                                                                                          | 0      | $ [****] |
| MoH Updates - Protocol Amendment                                                                  | RedHill will be responsible for regulatory authority submissions.                                                                                                                                                                                          | 0      | $ [****] |
| Annual Reviews (EC)                                                                               | Assume each site will require 1 IRB/IEC renewal(s).                                                                                                                                                                                                        | 48     | $ [****] |
| Drug Label Review/Translation                                                                     | RedHill will be responsible for packaging and labeling.                                                                                                                                                                                                    | 0      | $ [****] |
| TRIAL MASTER FILE                                                                                 |                                                                                                                                                                                                                                                       |   | $ [****] |
| Set up Trial Master File                                                                          |                                                                                                                                                                                                                                                       | 8      | $ [****] |
| Maintain Trial Master File                                                                        |                                                                                                                                                                                                                                                       | 88     | $ [****] |
| INVESTIGATOR MEETINGS                                                                             |                                                                                                                                                                                                                                                       |   | $ [****] |
| Plan and Manage Investigator Meeting(s)                                                           | Clinipace organize a Web-based Investigator Meeting.                                                                                                                                                                                                       | 40     | $ [****] |
| Prepare meeting binders                                                                           | Clinipace will create the meeting binder and ship to the sites. Sponsor will approve the contents of the binder. We have included cost for producing 41 binders.                                                                                           | 36.5   | $ [****] |
| Prepare Presentations                                                                             |                                                                                                                                                                                                                                                       | 40     | $ [****] |
| Attend investigator meeting: US                                                                   | Webinar                                                                                                                                                                                                                                                    | 48     | $ [****] |

----

| Project Team Training                                   | We have assumed a 4 hour training session.                                                                                                                                                                      | 16           | $ [****] |
|---------------------------------------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------------|----------|
| VENDOR MANAGEMENT                                       |                                                                                                                                                                                                            |         | $ [****] |
| Central IRB/IEC                                         |                                                                                                                                                                                                            | 14           | $ [****] |
| Central Laboratory                                      |                                                                                                                                                                                                            |         | $ [****] |
| INITIATION VISITS                                       |                                                                                                                                                                                                            |         | $ [****] |
| Perform Site Initiation Visits - US                     | 8 hours on-site, avg. 8 hours travel, 6 hours preparation including slides and protocol review, scheduling and reporting per site = 22 hours                                                                    | [****]       | $ [****] |
| INTERIM MONITORING VISITS                               |                                                                                                                                                                                                            |         | $ [****] |
| Develop Monitoring Plan                                 | Clinipace will complete the monitoring plan/guidelines. Clinipace will provide the draft monitoring plan to RedHill Biopharma Ltd. for review and approval. Based on 1 review cycle with RedHill Biopharma Ltd. | 12           | $ [****] |
| Perform interim monitoring visits: US                   | 8 hours on-site, 8 hours travel, 6 hours preparation, scheduling and reporting = 22 hours per visit.                                                                                                            | 594          | $ [****] |
| Remote Monitoring                                       |                                                                                                                                                                                                            | 104          | $ [****] |
| CLOSE-OUT VISITS                                        |                                                                                                                                                                                                            |         | $ [****] |
| Perform Close-out visits: US                            | 1 day closeout (8 hours) + 8 travel + 6 preparation, scheduling and reporting = 22 hours per visit                                                                                                              |  [****] | $ [****] |
| QUERY RESOLUTION                                        |                                                                                                                                                                                                            |         | $ [****] |
| Query Resolution - Data Lock                            | Clinipace monitors will assist data management with query resolution at study close in order to expedite database lock.                                                                                         | 44.8         | $ [****] |
| SITE MANAGEMENT                                         |                                                                                                                                                                                                            |         | $ [****] |
| In-house Site Management                                | This will be done by assigned CRA, to include in-house site management time during active clinical duration. Assume weekly calls to sites during clinical project duration.                                     | 208          | $ [****] |
| Lead Clinical Research Associate                        |                                                                                                                                                                                                            | 102          | $ [****] |
| PROJECT COMMUNICATIONS                                  |                                                                                                                                                                                                            |         | $ [****] |
| Client Kick-off/Training Meeting                        | Assume a 4 hour kick-off. Training meeting will be held between the Clinipace and Sponsor teams (via teleconference).                                                                                           | [****]       | $ [****] |
| Enrollment Reports                                      | Clinipace will provide enrollment reports to the sponsor via Tempo.                                                                                                                                             |         |     |
| Status Reports                                          | Clinipace monthly reports to sponsor, to include screening, enrollment, number of monitoring visits, CRFs harvested; queries outstanding, etc.                                                                  | 44           | $ [****] |
| Teleconferences with Sponsor                            | Assume monthly calls with sponsor.                                                                                                                                                                              | 73           | $ [****] |
| Provide newsletters                                     | Not requested                                                                                                                                                                                                   | 0            | $ [****] |
| External Sponsor / Clinipace Face to Face Team Meetings | Anticipate one meeting at the Sponsor attended by the Clinipace Project Director.                                                                                                                               | 18           | $ [****] |
| CRA Study Management                                    | General CRA time for communication with Sponsor and Medical Monitor, file maintenance etc.                                                                                                                      | 104          | $ [****] |
| Internal Team Meetings                                  | Clinipace will hold monthly internal team meetings during the course of this project.                                                                                                                           | 73           | $ [****] |

----

| PROJECT MANAGEMENT                                                                                                                       |                                                                                                                                                                                 |   | $ [****] |
|------------------------------------------------------------------------------------------------------------------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|----------|
| Project Management                                                                                                                       | General Project Management to include interaction with monitors; review of all documents and general ad hoc sponsor communication                                                    | 438    | $ [****] |
| Clinical Trial Coordinator - Administrative Support                                                                                      |                                                                                                                                                                                 | 414    | $ [****] |
| Financial Reporting                                                                                                                      |                                                                                                                                                                                 | 44     | $ [****] |
| Return Study Files to Sponsor                                                                                                            |                                                                                                                                                                                 | 16     | $ [****] |
| QUALITY ASSURANCE                                                                                                                        |                                                                                                                                                                                 | 0      | $ [****] |
| QA Visits                                                                                                                                | InSymbiosis                                                                                                                                                                          |   |     |
| STUDY DRUG                                                                                                                               |                                                                                                                                                                                 |   | $ [****] |
| Obtain import permits for study drug and supplies; prepare and review import paperwork                                                   | InSymbiosis/RedHill                                                                                                                                                                  | 0      | $ [****] |
| Oversee Drug Distribution to Sites from Warehouse                                                                                        | InSymbiosis/RedHill                                                                                                                                                                  | 0      | $ [****] |
| Obtain any necessary export permits for shipping of lab samples to central lab and for return of unused study medication at end of study | Not applicable                                                                                                                                                                       | 0      | $ [****] |
| Drug depot and Central lab contact and local issues management throughout the study                                                      | InSymbiosis/RedHill                                                                                                                                                                  | 0      | $ [****] |
| MEDICAL MONITORING                                                                                                                       |                                                                                                                                                                                 |   | $ [****] |
| Provide medical contact with sites                                                                                                       | Clinipace will provide sites with a contact person to answer site questions.                                                                                                         | 33     | $ [****] |
| Review SAEs                                                                                                                              |                                                                                                                                                                                 | 2.5    | $ [****] |
| Review patient eligibility, lab alerts, coding and listings                                                                              |                                                                                                                                                                                 | 0.5    | $ [****] |
| DRUG SAFETY/PHARMACOVIGILANCE                                                                                                            |                                                                                                                                                                                 |   | $ [****] |
| Create Safety Monitoring Plan                                                                                                            | Clinipace will develop the safety plan. Clinipace will provide the draft plan to RedHill Biopharma Ltd. for review and approval. Based on 1 review cycle with RedHill Biopharma Ltd. | 16     | $ [****] |
| Set-up SAE Database                                                                                                                      |                                                                                                                                                                                 | 57     | $ [****] |
| Document and manage SAEs                                                                                                                 | Based on [****] SAEs.                                                                                                                                                                | 20     | $ [****] |
| Follow-up SAEs                                                                                                                           |                                                                                                                                                                                 | 5      | $ [****] |
| Report SAEs to regulatory authorities                                                                                                    | Based on [****] expedited SAEs.                                                                                                                                                      | 8      | $ [****] |
| Update all Study Sites of SAEs requiring Expedited Safety Reports/Distribute IND Safety Reports                                          | Clinipace will notify each site of SAEs that require reporting.                                                                                                                      | 4      | $ [****] |
| Write Safety Narratives                                                                                                                  | Based on 16 narratives.                                                                                                                                                              | 22     | $ [****] |
| SAE Reconciliation                                                                                                                       | Based on [****] reconciliations throughout the course of the project.                                                                                                                | 48     | $ [****] |
| DATA MANAGEMENT                                                                                                                          |                                                                                                                                                                                 |   | $ [****] |
| STUDY PLATFORM                                                                                                                           |                                                                                                                                                                                 |   |     |
| Data Management Fees                                                                                                                     | ▪ Includes License Fees, Hosting and Technical Support                                                                                                                         |   | $ [****] |

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| Hardware & Systems                     | ▪ 3 servers▪ Routers/firewall▪ Tape drive (backup)▪ Redundancy▪ Security (IPS, AVS)▪ Bandwidth                                                                          |   | [****]   |
|--------------------------------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------|----------|
| CRF Revisions                              |                                                                                                                                                                                                        |   | [****]   |
| IMPLEMENTATION                             |                                                                                                                                                                                                        |   |     |
| Clinical Data Capture Module               | ▪ XML file creation & load▪ eCRF design▪ Edit check coding▪ Data element coding▪ Workflow configuration▪ Database development▪ Testing                        |   | $ [****] |
| Reports                                    |                                                                                                                                                                                                        |   | [****]   |
| Randomization                              |                                                                                                                                                                                                        |   | $ [****] |
| User Administration                        |                                                                                                                                                                                                        |   | [****]   |
| Validation (testing & documentation)   |                                                                                                                                                                                                        |   | $ [****] |
| Training Manual                            |                                                                                                                                                                                                        |   | [****]   |
| User training (TTT)                        |                                                                                                                                                                                                        |   | [****]   |
| Printable (PDF) CRFs                       |                                                                                                                                                                                                        |   | [****]   |
| STUDY DATA MANAGEMENT AND SUPPORT          |                                                                                                                                                                                                        |   |     |
| Data Management Plan                       |                                                                                                                                                                                                        |   | $ [****] |
| Code book creation                         |                                                                                                                                                                                                        |   | [****]   |
| Data Entry                                 | Not applicable                                                                                                                                                                                              |   |     |
| Verification                               | Not applicable                                                                                                                                                                                              |   |     |
| CRF Tracking                               | Not applicable                                                                                                                                                                                              |   |     |
| Coding                                     | Based on 10 codes per patient.                                                                                                                                                                              |   | $ [****] |
| Queries                                    | Based on 10 queries per patient.                                                                                                                                                                            |   | $ [****] |
| Data Imports                               | Based on 2 data transfers/imports from outside vendors.                                                                                                                                                     |   | $ [****] |
| Data exports/monthly                       |                                                                                                                                                                                                        |   | [****]   |
| Data export/final                          |                                                                                                                                                                                                        |   | [****]   |
| Data warehousing/archiving                 |                                                                                                                                                                                                        |   | [****]   |
| Administration                             |                                                                                                                                                                                                        |   | $ [****] |
| STATISTICAL ANALYSIS                       |                                                                                                                                                                                                        |   | $ [****] |
| Develop Statistical Analysis Plan          | Clinipace will develop the Statistical Analysis Plan. Clinipace will provide the draft analysis plan to RedHill Biopharma Ltd. for review and approval. Based on 1 review cycle with RedHill Biopharma Ltd. | 32     | $ [****] |
| Create Randomization Plan                  |                                                                                                                                                                                                        | 20     | $ [****] |
| Conduct SAS programming and QC of all TLFs | Based on 8 unique tables, 16 non unique tables, 3 unique figures, 6 non unique figures and 20 listings.                                                                                                     | 114    | $ [****] |
| Prepare Interim Analysis and Report        | Not applicable                                                                                                                                                                                              |   |     |
| Prepare Final Analysis and Report          |                                                                                                                                                                                                        | 40     | $ [****] |
| QC All Analysis and Report                 |                                                                                                                                                                                                        | 15     | $ [****] |
| FINAL REPORT                               |                                                                                                                                                                                                        |   | $ [****] |

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| Write Clinical Study Report (CSR) | Clinipace will develop the final report for the study. Clinipace will provide the draft report to RedHill Biopharma Ltd. for review and approval. Based on [****] review cycles with RedHill Biopharma Ltd. | 134          | $ [****]        |
|-----------------------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|--------------|-----------------|
| TOTAL SERVICES                    |                                                                                                                                                                                                        | 3992         |   $ [****] |
| [****]                            |                                                                                                                                                                                                        |         | $ [****]        |
| SERVICES COSTS GRAND TOTAL        |                                                                                                                                                                                                        |   3,992 | $ [****]        |

| 2.0   | RedHill agrees to pay Clinipace a professional fee of US $ [****] (“Fee”) as total payment for the full scope of Services and Tasks.  Any task reduced in scope will be credited (on a pro-rata basis in accordance with the actual hours spent) for hours budgeted in the agreement but not performed in full. A down payment of [****] shall be due and payable net 5 days upon Clinipace’s receipt of a fully executed copy of this Attachment A-1.  From then on, RedHill will be invoiced for the tasks actually performed and milestones reached by Clinipace ("Milestone Invoice"). Each Milestone Invoice shall be itemized in sufficient detail to permit independent auditing and verification that the work covered by such Milestone Invoice has been properly performed and the relevant milestone reached. Once the Study Activities are initiated, as part of the Fee and included therein,  and as detailed in the table below, RedHill will pay Clinipace a Quarterly Fee of $ [****], calculated from the date of initiation of Study Activities. |
|-----------------|---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|

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| Milestone Payments: Pre-IND                                                             | $ [****] |
|-----------------------------------------------------------------------------------------|----------|
| Execution of the Agreement                                                              | $ [****] |
| Protocol and ICF Completed                                                              | $ [****] |
|                                                                                    |     |
| Milestone Payments: Post-IND                                                            | $ [****] |
| Initiation of study activities                                                          | $ [****] |
| Database set-up complete (go live)                                                      | $ [****] |
| First Subject Enrolled                                                                  | $ [****] |
| Last Subjects Enrolled [****]                                                           | $ [****] |
| Last CRF Collected                                                                      | $ [****] |
| Final CSR                                                                               | $ [****] |
|                                                                                    |     |
| Total Milestone Payments                                                                | $ [****] |
|                                                                                    |     |
| Quarterly Payments: Beginning Post IND                                                  |     |
| Quarterly Payment 1- Invoice due at 3 months post Initiation of Study Activities        | $ [****] |
| Quarterly Payment 2 – Invoice due at 6 months post Initiation of Study Activities | $ [****] |
| Quarterly Payment 3– Invoice due at 9months post Initiation of Study Activities   | $ [****] |
| Quarterly Payment 4– Invoice due at 12 months post Initiation of Study Activities | $ [****] |
| Total Monthly Payments                                                                  | $ [****] |
|                                                                                    |     |
| Total                                                                                   | $ [****] |

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| INDIRECT COSTS                                               | (PASS-THROUGH EXPENSES)                                                                                                                                                        | Estimated Cost |
|--------------------------------------------------------------|--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------------|
| / Ministry of Health and Ethics Committee Fees               | Assume 1 initial submission only (no amendments) and 1 annual review(s).                                                                                                       | $24,000        |
| CRA AirCards                                                 |                                                                                                                                                                           | $1,350         |
| Shipping                                                     |                                                                                                                                                                           | $5,500         |
| Phone (Long Distance)                                        |                                                                                                                                                                           | $5,500         |
| Supplies                                                     |                                                                                                                                                                           | $3,300         |
| Translation costs                                            | Clinipace will work with the sites and a translation vendor(s) to translate appropriate study documents into local languages. Includes translation into 2 different languages. | $20,000        |
| Plan and Manage Investigator Meeting(s) with meeting planner | Web-based IM - hosting fees                                                                                                                                                    | $500           |
| Travel                                                       | Includes travel for monitoring visits, client meetings, supervision visits, QA visits.                                                                                         | $52,750        |
|                                                         |                                                                                                                                                                           |           |
| ESTIMATED INDIRECT COSTS TOTAL                               |                                                                                                                                                                           | $112,900       |

| Investigator Grants |   | $ [****] |
|---------------------|--------|----------|

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| CLINIPACE, INC.: |   | RedHill Biopharma Ltd.: |   |
|------------------|--------|-------------------------|--------|
|             |   |                    |   |   |   |
|             |   |                    |   |   |   |
| By:              | /s/    |                    | By:    | /s/ |   |
|             |   |                    |   |   |   |
| Name:            |   |                    | Name:  |   |   |
|             |   |                    |   |   |   |
| Title:           |   |                    | Title: |   |   |
|             |   |                    |   |   |   |
| Date:            |   |                    | Date:  |   |   |

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