# K 

# - 46Lf

J~,~EO S ),TF UNITED STATES ENVIRONMENTAL PROTECTION AGENCY D A Z Office of Air Quality Planning and Standards Research Triangle Park, North Carolina 2771 1 ;~"'9 Pqo,~< ~r August 11, 1993 MEMORANDUM SUBJECT : Subject Data Supplied by the Researchers for the Recent

Controlled Human Studies Analyzed in the Staff Paper Supplement and Accomp nying Memorandum FROM : Eric Smit h

Ambient Standards Branch ( MD-12 ) TO : The SO2 Docket ( A-84-25 )

The contents of item IV-B-5, Docket No . A-84-25 are explained below .

iLen~ Iti- b - ~) is C uiupuseu uL L iitee pdrts, ts ana L : Item IV-B-5, part A is composed of copies of spreadsheetscontaining the information from the raw data supplied in Item IVB-5, part B, as entered into a computer for calculations by EPA staff . These are the numbers used to perform the calculations detailed in the draft Staff Paper Supplement and the memorandum entitled "Analysis of Recent SO2 Controlled Human Studies ." Summaries of lung function information from these spreadsheets were provided as Attachment 3 to that memorandum . For the symptom spreadsheets, the column of "Exc" symptoms records the maximum symptoms at exercise, and thus may equal the SO2 symptom score but not "cancel it out," if the SO2 symptoms score was reported for an different one of the three symptom categories ( chest tightness/discomfort, shortness of breath/breathlessness, and wheeze) . The original sheets need to be referred to in these cases to check on the final symptom score tabulations . X's next to scores denote when pre-exposure scores equaled post-exposure scores . ( These X's "cancel out" SO2 symptoms, and exercise symptoms when tabulated separately, but not when determining if exercise symptoms total SO2 symptoms for the "Final Symptom Scores After Correction" table . See the memorandum "Analysis of Recent SO, Controlled Human Studies" if more information is desired on how these values were used to determine the final symptoms scores . For the final symptom scores, scores of both "0" and "5" were treated as "0" for simplicity, since neither were counted as symptoms in the final analyses .p . 2

2 Item IV-B-5, part B contains the original data from which the numbers in the spreadsheets were obtained : The lung function data for the Roger et al . (1985) study is in the form of a handwritten summary sheet provided to me by Dr
. Howard Kehrl of HERL . The symptoms data is provided in the form of subject by subject computer printouts, as provided to me by Dr . Don Hortsman of HERL . The information on these sheets is coded as follows, as detailed on the sheet for Subj . 001 : Cohort 1 - 0 .0 ppm Clean Air Exposure Cohort 2 - 0 .25 ppm SO2 exposure Cohort 3 - 0 .5 ppm SO2 exposure Cohort 4 - 1 .0 ppm SO2 exposure Cohort 5 - 2 .0 ppm SO2 exposur e Sywp ~u,«z=, 6d La was useu Z .Luiu Session u tor pre-exposure symptoms and Session 1 for post-exposure symptoms, which Dr . Don Horstman communicated to me was the symptoms report occurring after the lst exercise period . The lung function and symptoms data from Linn et al . (1987, 1988, and 1990), is coded as follows, as detailed in the copy of the handwritten sheet provided for me by Dr . William Linn which is included with the data (I have added the information for the 1988 and 1990 subject data to the sheet myself as per information I received from Dr . Linn for these groups) . The exposures are coded by the number given for "Cond ." or "Exposure Code", with a given exposure code signifying a different exposure for subjects in varying subject groups : Group 258 Clean air (Rl, R2) - 1, 5 0 .2 ppm SO2 (Rl, R2) - 3, 7 0 .4 ppm SO2 (R1, R2) - 4, 8 0 .6 ppm SO2 (R1, R2) - 2, 6 Group 259 Clean air (Ri, R2) - 3, 8 0 .2 ppm SO2 (Rl, R2) - 1, 6 0 .4 ppm SO2 (R1, R2) - 2, 5 0 . 6 ppm SO2 (R1, R2) - 4, 7 Group 260 Clean air (R1, R2) - 1, 6 0 .2 ppm SO2 (R1, R2) - 4, 7 0 . 4 ppm SO2 (RI, R2) - 3, 8 0 .6 ppm SO2 (Ri, R2) - 2, 5p . 3

3 Group 262 Clean air (R1, R2) - 4, 5 0 .2 ppm SO2 (R1, R2) - 3, 8 0 .4 ppm SO2 (R1, R2) - 1, 6 0 .6 ppm SO2 (Rl, R2) - 2, 7 Group 267 Clean air (R1, R2) - 3, 8 0 . 2 ppm SO2 (R1, R2) - 2, 7 0 . 4 ppm SO2 (R1, R2) - 1, 5 0 .6 ppm SOz (R1, R2) - 4, 6 Group 271 Clean air (Rl, R2) - 2, 6 0 . 2 ppm SO2 (Rl, R2) - 3, 8 0 .4 ppm SO2 (R1, R2) - 4, 5 0 .6 ppm SO2 (Rl, R2) - 1, 7 Group 277 Clean air, untreated - 5 (1988 study) 0 .3 ppm SO2, untreated - 1 0 .6 ppm SO2, untreated - 7 Clean air, placebo - 3 0 .3 ppm SO2, placebo - 9 0 .6 ppm SO2, placebo - 2 Clean air, drug - 8 0 .3 ppm SO2, drug - 6 0 .6 ppm SO2, drug - 4 Group 281 Clean air, low medications - 7 (1990 study) 0 .3 ppm SO2, low medications - 4 0 .6 ppm SO2, low medications - 1 Clean air, normal medications - 8 0 .3 ppm SO2, normal medications - 5 0 .6 ppm SO2, normal medications - 2 Clean air, high medications - 9 0 .3 ppm SO2, high medications - 6 0 .6 ppm SO2, high medications - 3 The Linn et al . (1988) study is also referred to on the original sheets as the 1987 SO2 Medications Study, and the Linn et al . (1990) study is also referred to as the 1988 SO2 Medication Study, since these were when the studies were carried out (but not published) . The Linn et al . (1988) study SRaw data was provided as a computer printout which was read in the following fashion : Observations 12 (before exposure, after pretreatment) and 13 (after exposure) gave pre-and post-Sraw values for clean air, untreated . Observations 72 (before exposure, after pretreatment) and Observations 73 (after exposure) gave pre-p . 4

4 and post-Sraw values for 0 .6 ppm . This is as described on the sheet "Appendix : Specific Airway Resistance Data for Individual Subjects" as provided to me by Dr . Linn and included amongst the materials . From the symptoms sheets, scores were recorded from "Right Now" for pre-exposure symptoms and "Exercise I" for post-exposure symptoms for the Linn et al . (1987) study ; from "In Chamber/Post Meds Test" (Card 5) for pre-exposure symptoms and "O n Exiting/Exercise" (Card 6) for post-exposure symptoms for the Linn et al . (1988) study ; and "30 Min . Post Meds Test" for preexposure symptoms and "40 Min . Exercise" for post-exposure symptoms for the Linn et al . (1990) study .

Item IV-B-5, part C contains copies of written correspondence between myself and the Rancho Los Amigos researchers concerning this data . The symptoms data as contained in part B contain the revisions or additional information for a few subjects that I had requested and that was supplied to me by Dr . Linn and Dr . Deborah Shamoo in response to my request on June 22, 1993 . In some cases they jotted down scores for certain subjects and conditions, but since they were unaware of the periods (e .g ., "Exercise I") for which I was scoring symptoms, I did not use those number as sent directly . Instead I used those numbers to figure out which conditions should be assigned to which trials amongst the sheets I already had, or in most cases they sent along the original sheets again for clarification . So, I revised my sheets by taking into account the information they provided me or inserting additional raw data sheets which were sent for some of the subjects when I needed them . The lung function data required no revisions as per the communication on July 2, 1993, because this correspondence simply confirmed that the raw data sheets they had sent me contained the accurate lung function scores .p . 5



### ROGER ET AL ., 1985 

# A-1 MILD ASTHMATIC S 1 .0 PPM S02 Rank

S02 Total EXC EXC Adj S02 Subj . PreExp PostExp SRaw PreExp PostExp SRaw SRaw SRaw 1 6 .43 10 .40 61 .74 6 .34 6 .52 2 .84 58 .90 516 .19 3 6 .43 13 .40 108 .40 9 .56 14 .87 55 .54 52 .85 420 .83 4 5 .88 14 .88 153 .06 11 .54 17 .74 53 .73 99 .34 343 .40 7 4 .53 12 .45 174 .83 5 .05 7 .20 42 .57 132 .26 304 .24 12 10 .23 9 .94 -2 .83 8 .20 5 .51 -32 .80 29 .97 289 .07 13 2 .99 7 .25 142 .47 4 .60 4 .94 7 .39 135 .08~ 256 .75 14 6 .70 13 .03 94 .48 2 .82 3 .71 31 .56 62 .92 249 .37 15 5 .02 17 .85 255 .58 4 .67 4 .96 6 .21 249 .37 170 .06 16 2 .84 5 .68 100 .00 2 .90 3 .15 8 .62 91 .38 162 .53 18 4 .65 8 .31 78 .71 4 .65 4 .98 7 .10 71 .61 135 .83 19 9 .93 44 .94 352 .57 10 .14 15 .04 48 .32 304 .24 135 .08 20 from 0 .5 ppm 4 .58 34 .97 663 .54 2 .83 7 .00 147 .35 516 .19 132 .26 23 7 .62 27 .93 266 .54 8 .58 9 .42 9 .79 256 .75 127 .00 24 4 .31 13 .30 208 .58 4 .62 6 .40 38 .53 170 .06 109 .18 26 4 .37 12 .00 174 .60 2 .76 3 .83 38 .77 135 .83 99 .34 29 11 .42 67 .88 494 .40 13 .28 23 .05 73 .57 420 .83 91 .38 30 6 .14 19 .61 219 .38 6 .86 10 .76 56 .85 162 .53 81 .46 36 3 .55 4 .51 27 .04 3 .74 4 .14 10 .70 16 .35 81 .28 37 6 .65 20 .24 204 .36 7 .49 19 .61 161 .82 42 .55 71 .61 39 5 .95 14 .36 141 .34 5 .91 9 .46 60 .07 81 .28 62 .92 40 9 .36 15 .00 60 .26 8 .13 9 .00 10 .70 49 .56 58 .90 42 6 .00 10 .39 73 .17 5 .81 7 .79 34 .08 39 .09 52 .85 43 5 .35 29 .45 450 .47 5 .44 14 .22 161 .40 289 .07 49 .56 44 8 .39 15 .49 84 .62 8 .53 8 .80 3 .17 81 .46 42 .55 45 10 .20 32 .21 215 .78 4 .39 9 .07 106 .61 109 .18 39 .09 46 8 .16 40 .18 392 .40 5 .51 8 .21 49 .00 343 .40 29 .97 48 5 .06 7 .89 55 .93 4 .68 7 .22 54 .27 1 .66 16 .35 50 4 .35 14 .34 229 .66 5 .27 10 .68 102 .66 127 .00 1 .66 AVG W/# 20 195 .75 48 .23 147 .52p . 6

ROGER ET AL ., 198 5 

### MILD ASTHMATIC S 0 .5 PPM S02 Rank

S02 Total EXC EXC Adj S02 Subj . PreExp PostExp SRaw PreExp PostExp SRaw SRaw SRaw 1 7 .08 6 .31 -10 .88 6 .34 6 .52 2 .84 -13 .71 516 .19 3 7 .08 10 .05 41 .95 9 .56 14 .87 55 .54 -13 .59 196 .18 4 8 .57 21 .66 152 .74 11 .54 17 .74 53 .73 99 .02 145 .26 7 4 .32 9 .85 128 .01 5 .05 7 .20 42 .57 85 .44 107 .14 12 10 .53 12 .89 22 .41 8 .20 5 .51 -32 .80 55 .22 103 .30 13 3 .65 4 .76 30 .41 4 .60 4 .94 7 .39 23 .021 99 .02 14 5 .05 6 .71 32 .87 2 .82 3 .71 31 .56 1 .31 89 .36 15 4 .41 11 .09 151 .47 4 .67 4 .96 6 .21 145 .26 85 .44 16 2 .53 3 .77 49 .01 2 .90 3 .15 8 .62 40 .39 63 .26 18 4 .25 7 .24 70 .35 4 .65 4 .98 7 .10 63 .26 63 .14 19 11 .72 29 .94 155 .46 10 .14 15 .04 48 .32 107 .14 59 .45 20 4 .58 34 .97 663 .54 2 .83 7 .00 147 .35 516 .19 55 .22 23 8 .70 11 .79 35 .52 8 .58 9 .42 9 .79 25 .73 47 .29 24 5 .43 8 .72 60 .59 4 .62 6 .40 38 .53 22 .06 40 .67 26 4 .48 8 .88 98 .21 2 .76 3 .83 38 .77 59 .45 40 .39 29 14 .84 26 .82 80 .73 13 .28 23 .05 73 .57 7 .16 25 .73 30 8 .03 20 .89 160 .15 6 .86 10 .76 56 .85 103 .30 23 .02 36 4 .32 4 .70 8 .80 3 .74 4 .14 10 .70 -1 .90 22 .06 37 8 .04 24 .32 202 .49 7 .49 19 .61 161 .82 40 .67 7 .16 39 5 .63 9 .37 66 .43 5 .91 9 .46 60 .07 6 .36 6 .36 40 5 .32 4 .81 -9 .59 8 .13 9 .00 10 .70 -20 .29 1 .31 42 5 .77 7 .50 29 .98 5 .81 7 .79 34 .08 -4 .10 -1 .90 43 6 .91 21 .33 208 .68 5 .44 14 .22 161 .40 47 .29 -4 .10 44 9 .14 15 .20 66 .30 8 .53 8 .80 3 .17 63 .14 -13 .59 45 6 .42 10 .35 61 .21 4 .39 9 .07 106 .61 -45 .39 -13 .71 46 7 .99 27 .58 245 .18 5 .51 8 .21 49 .00 196 .18 -20 .29 48 5 .05 6 .52 29 .11 4 .68 7 .22 54 .27 -25 .16 -25 .16 50 5 .51 16 .09 192 .01 5 .27 10 .68 102 .66 89 .36 -45 .39 AVG w/ #20 107 .97 48 .23 59 .74p . 7 ,4-3

1987 0 .4 PPM Round 1 

### SRaw Tota l S02 (S02/ EXC EXC/ S02 Rank Subject Pre SRaw CleanAir Pre SRaw Clean Air AdjSRaw SRaw 297 M 5 .35 9 .72 81 .68 5 .01 4 .93 -1 .60 83 .28 221 .61 585 M 4 .32 5 .89 36 .34 3 .6O 4 .46 23 .89 12 .45 159 .56 608 M 5 .37 13 .78 156 .61 3 .07 4 .09 33 .22 123 .39 123 .39 724 M 6 .78 10 .96 61 .65 4 .37 9 .92 127 .00 -65 .35 103 .96 726 M 5 .72 11 .43 99 .83 5 .61 8 .42 50 .09 49 .74 95 .82 778 M 6 .16 13 .49 118 .99 7 .51 9 .25 23 .17 95 .82 83 .28 877 M 4 .09 8 .35 104 .16 5 .04 5 .05 0 .20 103 .96 61 .54 879 M 3 .57 11 .39 219 .05 2 .74 4 .37 59 .49 159 .56 49 .74 885 M 5 .84 17 .55 200 .51 8 .91 7 .03 -21 .10 221 .61 27 .57 893 M 3 .87 5 .19 34 .11 3 .44 4 .96 44 .19 -10 .08 12 .45 979 M 7 .46 8 .95 19 .97 12 .24 11 .31 -7 .60 27 .57 10 .41 1028 M 5 .75 2 .31 -59 .83 5 .21 7 .37 41 .46 -101 .28 7 .14 1029 M 6 .46 13 .13 103 .25 5 .25 7 .44 41 .71 61 .54 -10 .08 1067 M 7 .04 15 .28 117 .05 5 .64 11 .30 100 .35 16 .69 -17 .84 1094 M 4 .32 4 .96 14 .81 4 .41 5 .85 32 .65 -17 .84 -65 .35 1096 M 3 .69 4 .96 34 .42 3 .96 5 .04 27 .27 7 .14 -101 .28 611 S 7 .85 9 .29 18 .34 8 .22 10 .87 32 .24 -13 .89 514 .67 780S 5 .71 20 .57 260 .25 7 .55 15 .24 101 .85 158 .39 243 .67 884S 8 .37 49 .82 495 .22 8 .02 6 .46 -19 .45 514 .67 158 .39 892S 6 .43 20 .40 217 .26 3 .56 5 .96 67 .42 149 .85 149 .85 1008 S 4 .99 8 .54 71 .14 0 .50 5 .77 -12 .04 83 .18 108 .23 1011 S 5 .74 25 .44 343 .21 4 .35 8 .68 99 .54 243 .67 83 .18 1024 S 4 .96 8 .43 69 .96 4 .54 6 .57 35 .74 34 .22 83 .07 1031 S 5 .02 9 .48 88 .84 4 .08 8 .35 104 .66 -15 .81 61 .98 1033 S 8 .90 17 .82 100 .22 4 .36 14 .34 228 .90 -128 .67 38 .62 1042S 10 .18 16 .76 64 .64 10 .96 8 .94 -18 .43 83 .07 34 .22 1045 S 10 .79 46 .26 328 .73 12 .20 54 .90 350 .00 -21 .27 16 .84 1047 S 5 .54 7 .22 30 .32 6 .78 9 .04 33 .33 -3 .01 13 .73 1048 S 5 .16 6 .01 16 .47 10 .25 7 .98 -22 .15 38 .62 0 .44 1051 S 17 .93 28 .95 61 .46 10 .59 76 .33 620 .77 -559 .31 -2 .83 1053 S 14 .45 17 .25 19 .35 15 .35 15 .74 2 .54 16 .84 -3 .01 1056 S 6 .86 9 .41 37 .17 8 .89 21 .66 143 .64 -106 .47 -3 .81 1060 S 4 .29 4 .58 6 .76 2 .04 3 .77 42 .80 -36 .04 -14 .49 1061 S 5 .37 7 .97 48 .42 8 .10 10 .91 34 .69 13 .73 -15 .81 1062S 4 .38 7 .38 68 .49 5 .41 3 .26 -39 .74 108 .23 -21 .27 1085 S 7 .84 15 .29 95 .03 7 .76 15 .10 94 .59 (1 .44 -31 .35 1086 S 5 .67 7_77 37 .0-1 5 .a6 7 .69 40 .84 -3 .81 -36 .04 1092 S 12 .21 14 .71 20 .48 11 .07 16 .81 51 .85 -31 .35 -106 .47 1098 S 5 .70 9 .42 65 .20 5 .49 5 .67 3 .25 61 .98 -121 .09 1 100 S 10 .25 11 .39 1 1 .1 2, 7 .17 ~ .17 1 3 .95 -2 .83 -55() .,-) 1p . 8

1987 0 .4 PPM Round 1 

### FEV Tota l S02 (S02/ EXC EXC/ S02 Rank Subject Pre FEV CleanAir Pre FEV Clean Air AdjSRaw FEV 297 M 2 .88 2 .71 -5 .90 2 .82 2 .91 3 .19 -9 .09 -36 .15 585 M 2 .22 1 .98 -10 .81 2 .20 2 .06 -6 .36 -4 .45 -23 .56 608 M 3 .45 2 .35 -31 .88 3 .56 3 .23 -9 .27 -22 .61 -22 .61 724 M 2 .67 2 .09 -21 .72 2 .66 2 .54 -4 .51 -17 .21 -21 .73 726 M 3 .47 3 .33 -4 .03 3 .60 3 .28 -8 .89 4 .85 -17 .21 778 M 3 .92 3 .11 -20 .66 3 .86 3 .58 -7 .25 -13 .41 -16 .29 877 M 2 .64 2 .26 -14 .39 2 .64 2 .69 1 .89 -16 .29 -13 .41 879 M 3 .42 2 .89 -15 .50 3 .44 3 .34 -2 .91 -12 .59 = -12 .59 885 M 3 .19 2 .50 -21 .63 3 .11 3 .17 1 .93 -23 .56 -9 .09 893 M 4 .55 4 .43 -2 .64 4 .41 4 .43 0 .45 -3 .09 -6 .73 979 M 3 .06 3 .17 3 .59 2 .96 3 .04 2 .70 0 .89 -5 .02 1028 M 2 .62 2 .06 -21 .37 2 .78 2 .79 0 .36 -21 .73 -4 .45 1029 M 1 .76 1 .45 -17 .61 1 .78 2 .11 18 .54 -36 .15 -3 .09 1067 M 2 .05 1 .50 -26 .83 2 .24 1 .89 -15 .63 -11 .20 0 .89 1094 M 2 .21 2 .12 -4 .07 2 .12 2 .14 0 .94 -5 .02 1 .83 1096 M 3 .28 3 .34 1 .83 3 .86 3 .86 0 .00 1 .83 4 .85 611 S 2 .59 2 .38 -8 .11 2 .61 2 .60 -0 .38 -7 .72 -46 .30 780 S 3 .23 2 .47 -23 .53 2 .95 2 .85 -3 .39 -20 .14 -43 .29 884 S 2 .93 1 .18 -59 .73 2 .98 2 .58 -13 .42 -46 .30 -39 .29 892 S 2 .78 1 .35 -51 .44 2 .87 2 .48 -13 .59 -37 .85 -37 .85 1008 S 2 .43 2 .03 -16 .46 2 .49 2 .06 -17 .27 0 .81 -20 .14 1011 S 4 .13 2 .23 -46 .00 4 .47 4 .17 -6 .71 -39 .29 -16 .04 1024 S 3 .09 2 .74 -11 .33) 2 .92 2 .85 -2 .40 -8 .9 3 -11 .07 1031 S 2 .00 2 .22 11 .00 1 .96 1 .81 -7 .65 18 .65 -9 .25 1033 S 2 .14 1 .69 -21 .03 2 .02 1 .74 -13 .86 -7 .17 -5 .93 1042S 1 .81 1 .45 -19 .89 1 .41 1 .74 23 .40 -43 .29 -7 .72 1045 S 2 .96 2 .09 -29 .39 2 .92 2 .53 -13 .36 -16 .04 -7 .66 1047 S 1 .69 1 .79 5 .92 2 .11 2 .05 -2 .84 8 .76 -7 .17 1048S 3 .04 2 .93 -3 .62 2 .54 2 .57 1 .18 -4 .80 -4 .80 1051 S 1 .88 1 .80 -4 .26 2 .18 2 .07 -5 .05 0 .79 -2 .98 1053S 1 .32 1 .20 -9 .09 1 .3(1 1 .04 -20 .00 10 .91 0 .79 1056 S 2 .25 1 .65 -26 .67 1 .65 1 .12 -32 .12 5 .45 0 .81 1060 S 2 .22 2 .21 -0 .45 2 .37 2 .43 2 .53 -2 .98 1 .19 1061 S 2 .66 2 .72 2 .26 2 .69 2 .65 -1 .49 3 .74 3 .74 1062S 2 .12 1 .85 -12 .74 2 .37 2 .04 -13 .92 1 .19 4 .23 1085 S 3 .04 2 .55 -16 .12 3 .07 2 .86 -6 .84 -9 .28 5 .45 1086 S 2 .09 1 .76 -15 .79 2 .() () 1 .92 -8 .13 -7 .66 8 .76 1092S 1 .98 1 .61 -18 .69 2 .05 1 .31 -36 .1O 17 .41 1(1 .91 1098S 2 .33 1 .93 -17 .17 2 .79 2 .62 -6 .09 -11 .07 17 .41 110()s 2 .04 2 .07 1 .47 2 .54 2 .47 -2 .76 4 .23) 1~ .65p . 9 

# A J~



### 1987 0 .6 PPM Round 1 SRaw Tota l

S02 S02 (S02/ EXC EXC EXC / Subject Pre SRaw CleanAir Pre SRaw Clean Air AdjSRaw Rank 297 M 5 .58 16 .05 187 .63 5 .01 4 .93 -1 .60 189 .23 1224 .24 585 M 4 .10 6 .31 53 .90 3 .60 4 .46 23 .89 30 .01 425 .94 608 M 4 .01 15 .23 279 .80 3 .07 4 .09 33 .22 246 .58 270 .13 724 M 6 .24 16 .11 158 .17 4 .37 9 .92 127 .00 31 .17 246 .58 726 M 4 .65 19 .54 320 .22 5 .61 8 .42 50 .09 270 .13 189 .23 778 M 7 .84 22 .18 182 .91 7 .51 9 .25 23 .17 159 .74 . 159 .74 877 M 3 .52 18 .52 426 .14 5 .04 5 .05 0 .20 425 .94 97 .10 879 M 2 .09 28 .92 1283 .73 2 .74 4 .37 59 .49 1224 .24 79 .08 885 M 6 .08 5 .93 -2 .47 8 .91 7 .03 -21 .10 18 .63 31 .17 893 M 4 .28 4 .97 16 .12 3 .44 4 .96 44 .19 -28 .06 30 .01 979 M 8 .76 16 .60 89 .50 12 .24 11 .31 -7 .60 97 .10 18 .63 1028 M 6 .45 9 .30 44 .19 5 .21 7 .37 41 .40 2 .7 3 15 .71 1029 M 7 .55 16 .67 120 .79 5 .25 7 .44 41 .71 79 .05 2 .73 1067 M 6 .51 12 .21 87 .56 5 .64 11 .30 100 .35 -12 .80 -12 .80 1094 M 5 .14 5 .01 -2 .53 4 .41 5 .85 32 .65 -35 .18 -28 .06 1096 M 4 .42 6 .32 42 .99 3 .96 5 .04 27 .27 15 .71 -35 .18 611 S 7 .52 9 .14 21 .54 8 .22 10 .87 32 .24 -10 .70 1170 .17 780S 5 .92 40 .05 576 .52 7 .55 15 .24 101 .85 474 .67 668 .04 884S 7 .68 37 .31 38 5 .81 8 .02 6 .46 -19 .45 405 .26 534 .19 892S 8 .67 27 .23 214 .07 3 .56 5 .96 67 .42 146 .66 474 .67 1008S 4 .50 34 .02 656 .00 6 .56 5 .77 -12 .04 668 .04 405 .26 1011 S 6 .73 28 .73 326 .8 9 4 .35 8 .610' 99 .54 227 . 35 233 .2(1 1024 S 6 .16 13 .92 125 .97 4 .84 6 .57 35 .74 90 .23 227 .35 1031 S 4 .68 7 .26 55 .13 4 .05 8 .35 104 .66 -49 .53) 146 .66 1033 S 12 .22 19 .16 56 .79 4 .36 14 .34 228 .90 -172 .11 90 .23 1042S 16 .48 11 .40 -30 .83 10 .96 8 .94 -18 .43 -1239 47 .26 1045 S 13 .54 133 .26 554 .19 12 .20 54 .90 350 .00 534 .19 46 .39 1047S 7 .44 11 .80 58 .60 6 .75 9 .04 33 .33 25?7 36 .45 1048S 5 .60 5 .81 3 .75 10 .25 7 .98 -22 .15 25J0 29 .22 1051 S 11 .25 17 .67 57 .07 10 .59 76 .33 620 .77 -563 .71 27 .55 1053 S 13 .96 18 .16 30 .09 15 .35 15 .74 2 .54 27 .55 25 .90 1056 S 7 .48 16 .82 124 .87 8 .89 21 .66 143 .64 - 18 .75 25 .27 1060 S 2 .35 1 .97 -16 .17 2 .64 3 .77 42 .80 -58 .97 16 .54 1061 S 6 .41 10 .97 71 .14 8 .10 10 .91 34 .69 36 .45 -10 .70 1062S 9 .86 121 .32 1110 .43 5 .41 3 .26 -39 .74 1170 .17 -12 .39 1085 S 6 .62 16 .01 141 .84 7 .76 15 .10 94 .59 47 .2(> -18 .78 1086 S 5 .09 9 .53 S 7 .2 ') 5 .46 7 .69 4U .8 4 46 .39 -4 9 .53 1092 S 8 .61 15 .59 81 .07 11 .07 16 .S 1 51 .85 29 .22 -58 .97 1098 S 6 .46 7 .74 19 .81 5 .49 5 .67 3 .28 10 .54 -172 .11 1 1OO S 9 .10 31 .59 247 .14 7 .17 (X .17 13 .95 2 3 3 .2() -50') .71P . 10

1987 0 .6 PPM Round 1 

### FEV Tota l

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1985 ROGER ET AL . MILD ASTHMATICS SYMPTOMS EXC

0 .25 PPM 0 .5 PPM 1 .00 PPM SYMPTO Subj . SB/CD WHZ SB/CD WHZ SB/CD WH Z 1 3 + (B) + (B) 4 + (B) + (B) + (B ) 7 2 .00 12 2 .00 2 .00 13 + (B ) 14 3 .00 15 2 .00 + (B/CD) 3 .00 16 2 .00 18 + (B) + (B/CD) 19 + (CD) + (CD ) 20 4 .00 "4" EXC=2 23 2 .00 3 .0 0 24 26 +(CD) EXC=2 29 2 .00 3 .0 0 30 36 37 2 .00 * Missing EXC=2 39 + (B) + (B) + (B ) 40 42 43 2 .00 3 .00 44 3 .00 4 5 

### 46 + (CD) 48 50 + (B/CD ) "( )" equals trace symptoms (1 "), with B or CD denoting whether for breathlessness or chest discomfort, respectively . 

### Prior symptoms 1 st set of responses ( Session 0), Exposure symptoms 2nd set of responses (Session 1) SYMPTOMS ROGER ET AL ., 198 5 Meth 1 Meth 2

0 .25 0 .50 1 .00 S02 = same as Meth 1 2+ 2/28 6/28 10/27 (11/28) EXC =

0 .07 0 .21 0 .37 (0 .39) 2+ 3/28 3+ 0 .00 1/28 7/28 0 .11 0 .04 0 .25 3 0 .00p . 18 

# %~--/q

1987 MILD ASTHMATICS SYMPTOMS FINAL SYM SCORES AFTE R 0 .4 PPM CORRECTION FOR EQUAL Round l EXERC OR PRE-EXP SCORE

S02 EXC R 1 SUBJECT CT/SOB WHZ CT/B WHZ SUBJECT CT/SOB WHZ 297 5 .00 0 .00 0 .00 0 .00 297 0 .00 0 .00 585 20 .00 20 .00 20 .00 20 .00 585 0 .00 0 .00 608 10 .00 10 .00 10 .00 5 .00 608 0 .00 10 .00 724 M 0 .00 0 .00 10 .00 5 .00 724 M 0 .00 0 .00 726 M 5 .00 0 .00 5 .00 0 .00 726 M 0 .00 0 .00 778 M 0 .00 10 .00 0 .00 0 .00 778 M 0 .0 0 10 .00 877 M 0 .00 0 .00 877 M 0 .0 0 0 .00 879 M 5 .00 5 .00 5 .00 5 .00 879 M 0 .00 0 .00 885 M 10 .00 0 .00 0 .00 0 .00 885 M 10 .00 0 .00 893 M 5 .00 5 .00 5 .00 0 .00 893 M 0 .00 0 .00 979 M 5 .00 0 .00 0 .00 0 .00 979 M 0 .00 0 .00 1028 M 0 .00 0 .00 0 .00 0 .00 1028 M 0 .00 0 .00 1029 M 5 .00 5 .00 0 .00 0 .00 1029 M 0 .00 0 .00 1067 M 10 .00 5 .00 10 .00 10 .00 1067 M 0 .00 0 .00 1094 M 5 .00 0 .00 10 .00 0 .00 1094 M 0 .00 0 .00 1096 M 0 .00 0 .00 0 .00 0 .00 1096 M 0 .00 0 .00 X denotes instances where pre-exposure symptoms = post-exposure symptom s Symptoms only counted from Exc 1 period

1987 R1 0 .4 PPM SYMPTOM S 

### MILDS Method 2

Any CT/SOB WHZ MILDS S02 EXC 10+ 3/16 1/16 2/16 10+ 5/16 5/15

0 .19 0 .06 0 .13 0 .31 0 .3 3 20+ 0/16 0/16 0/16 20+ 1/16 1/15

0 .00 0 .00 0 .00 0 .06 0 .07 (same as 0 .6 ppm)P . 19 

# %- 1

# S

1987 MODERATE ASTHMATIC SYMPTOMS FINAL SYM SCORES AFTE R 

### 0 .4 PPM CORRECTION FOR EQUAL Round 1 EXERC OR PRE-EXP SCORE

S02 EXC R 1 SUBJECT CT/SOB WHZ CT/B WHZ SUBJECT CT/SOB WHZ 611 S 0 .00 0 .00 0 .00 0 .00 611 S 0 .00 0 .00 780 S 5 .00 5 .00 5 .00 0 .00 780 S 0 .00 0 .00 884 S 20 .00 10 .00 10 .00 5 .00 884 S 20 .00 10 .00 892 S 20 .00 20 .00 10 .00 0 .00 892 S 20 .00 20 .00 1008S 5 .00 5 .00 0 .00 0 .00 1008S 0 .00 0 .00 1011 S 20 .00 20 .00 0 .00 0 .00 1011 S 20 .OQ 20 .00 1024 S 5 .00 5 .00 0 .00 0 .00 1024 S 0 .00 0 .00 1031 S 5 .00 0 .00 10 .00 10 .00 1031 S 0 .00 0 .00 1033 S 10 .00 5 .00 10 .00 10X 1033 S 0 .00 0 .00 1042S 20X 10X 0 .00 0 .00 1042S 0 .00 0 .00 1045 S 5 .00 5 .00 5 .00 5 .00 1045 S 0 .00 0 .00 1047 S 10X 10X 5 .00 5 .00 1047 S 0 .00 0 .00 1048 S 10X 5X 20X 5X 1048 S 0 .00 0 .00 1051 S 10 .00 10 .00 20 .00 10 .00 1051 S 0 .00 0 .00 1053 S 5 .00 5 .00 10 .00 5 .00 1053 S 0 .00 0 .00 1056 S 0 .00 0 .00 5 .00 0 .00 1056 S 0 .00 0 .00 1060 S 0 .00 0 .00 5 .00 0 .00 1060 S 0 .00 0 .00 1061 S 5 .00 0 .00 5 .00 5 .00 1061 S 0 .00 0,00 1062 S 0 .00 0 .00 5 .00 5 .00 1062 S 0 .00 0 .00 1085 S 0 .00 5 .00 0 .00 0 .00 1085 S 0 .00 0 .00 1086 S 5 .00 0 .00 5 .00 5 .00 1086 S 0 .00 0 .00 1092 S 0 .00 0 .00 0 .00 0 .00 1092 S 0 .00 0 .00 1098 S 0 .00 5 .00 0 .00 0 .00 1098 S 0 .00 0 .00 1100S 5 .00 0 .00 5 .00 5 .00 1 100 S 0 .00 0 .00 X denotes instances where pre-exposure symptoms = post-exposure symptom s 

### Symptoms only counted from Exc 1 period

1987 Al 0 .4 PPM SYMPTOM S MODS Method 2

Any CT/SOB WHZ MODS S02 EXC 10+ 3/24 3/24 3/24 10+ 5/24 6/24

0 .13 0 .13 0 .13 0 .21 0 .2 5 20+ 3/24 3/24 2/24 20+ 3/24 1/24

0 .13 0 .13 0 .08 0 .13 0 .04 (same as 0 .6 ppm)p . 20 14

# - 1

# tD

1987 MODERATE ASTHMATIC SYMPTOMS FINAL SYM SCORES AFTE R 0 .6 PPM CORRECTION FOR EQUAL Round 1 EXERC OR PRE-EXP SCORE

SO2 EXC R 1 SUBJECT CT/SOB WHZ CT/B WHZ SUBJECT CT/SOB WHZ 611 S 0 .00 0 .00 0 .00 0 .00 611 S 0 .00 0 .00 780 S 20 .00 0 .00 5 .00 0 .00 780 S 20 .00 0 .00 884 S 10 .00 10 .00 10 .00 5 .00 884 S 10 .00 10 .00 892 S 20 .00 30 .00 10 .00 0 .00 892 S 20 .00 30 .00 1008S 20 .00 20 .00 0 .00 0 .00 1008 S 20 .00 20 .00 1011 S 20 .00 20 .00 0 .00 0 .00 1011 S 20 .OQ 20 .00 1024 S 10 .00 10 .00 0 .00 0,00 1024 S 10 .00 10 .00 1031 S 0 .00 0 .00 10 .00 10 .00 1031 S 0 .00 0 .00 1033 S 10 .00 10 .00 10 .00 10X 1033 S 0 .00 0 .00 1042 S 0 .00 0 .00 0 .00 0 .00 1042 S 0 .00 0 .00 1045 S 30 .00 30 .00 5 .00 5 .00 1045 S 30 .00 30 .00 1047 S 10 .00 5 .00 5 .00 5 .00 1047 S 10 .00 0 .00 1048 S 5 .00 5 .00 20X 5X 1048 S 0 .00 0 .00 1051 S 10 .00 10 .00 20 .00 10 .00 1051 S 0 .00 0 .00 1053 S 20 .00 5 .00 10 .00 5 .66 i 053 S 20 .00 0 .00 1056 S 5 .00 0 .00 5 .00 0 .00 1056 S 0 .00 0 .00 1060 S 5 .00 0 .00 5 .00 0 .00 1060 S 0 .00 0 .00 1061 S 0 .00 0 .00 5 .00 5 .00 1061 S 0 .00 0 .00 1062 S 20 .00 10 .00 5 .00 5 .00 1062 S 20 .00 10 .00 1085 S 10 .00 20 .00 0 .00 0 .00 1085 S 10 .00 20 .00 1086 S 5 .00 5 .00 5 .00 5 .00 1086 S 0 .00 0 .00 1092 S 5 .00 5 .00 0 .00 0 .00 1092 S 0 .00 0 .00 1098 S 0 .00 0 .00 0 .00 0 .00 1098 S 0 .00 0 .00 1100 S 10 .00 10 .00 5 .00 5 .00 1 100 S 10 .00 10 .00 X denotes instances where pre-exposure symptoms = post-exposure symptom s 

### Thus, only subject 1 029M had a pre-exposure score equalling their post-S02 symptoms scor e In some cases (e .g ., subj 884) exercise score seems to equal S02 score , but does not cancel the SO2 score out . In actuality, these are cases in whic h 

### EXC score high for either CT or SOB, while S02 score high for the other or both categories Symptoms recorded for Exercise Period 1

1987 Al 0 .6 PPM SYMPTOMS Method 2 MODS Any CT/SOB WHZ MODS S02 EXC 10+ 12/24 12/24 9/24 10+ 14/24 6/2 4

0 .50 0 .50 0 .38 0 .58 0 .25 20+ 8/24 7/24 5/24 20+ 8/24 1/24

0 .33 0 .29 0 .21 0 .33 0 .04p . 21 

# A 

# -~ 7

1987 MILD ASTHMATICS SYMPTOM S 0 .6 PPM FINAL SYM SCORES AFTER Round l CORRECTION FOR EQUAL EXERC OR PRE-EXP SCORE S02 EXC R 1 SUBJECT CT/SOB WHZ CT/B WHZ SUBJECT CT/SOB WHZ 297 10 .00 20 .00 0 .00 0 .00 297 10 .00 20 .00 585 20 .00 20 .00 20 .00 20 .00 585 0 .00 0 .00 608 10 .00 10 .00 10 .00 5 .00 608 0 .00 10 .00 724 M 5 .00 0 .00 10 .00 5 .00 724 M 0 .00 0 .00 726 M 10 .00 0 .00 5 .00 0 .00 726 M 10 .00 0 .00 778 M 0 .00 10 .00 0 .00 0 .00 778 M O .Ot) 10 .00 877 M 0 .00 0 .00 877 M 0 .00 0 .00 879 M 10 .00 5 .00 5 .00 5 .00 879 M 0 .00 0 .00 885 M 5 .00 0 .00 0 .00 0 .00 885 M 0 .00 0 .00 893 M 5 .00 0 .00 5 .00 0 .00 893 M 0 .00 0 .00 979 M 10 .00 0 .00 0 .00 0 .00 979 M 10 .00 0 .00 1028 M 0 .00 0 .00 0 .00 0 .00 1028 M 0 .00 0 .00 1029 M 10X 0 .00 0 .00 0 .00 1029 M 0 .00 0 .00 1067 M 10 .00 0 .u0 10 .00 10 .00 1067 M 0 .06 0 .00 1094 M 5 .00 0 .00 10 .00 0 .00 1094 M 0 .00 0 .00 1096 M 0 .00 0 .00 0 .00 0 .00 1096 M 0 .00 0 .00 X denotes instances where pre-exposure symptoms = post-exposure symptom s 

### Thus, only subject 1029M had a pre-exposure score equalling their post-S02 symptoms scor e Symptoms recorded for exercise period 1 1987 R1 0 .6 PPM SYMPTOMS Method 2 MILDS Any CT/SOB WHZ MILDS S02 EXC 10+ 5/16 3/16 3/16 10+ 7/16 5/15

0 .31 0 .19 0 .19 0 .44 0 .3 3 20+ 1/16 0/16 1/16 20+ 2/16 1/15

0 .06 0 .06 0 .13 0 .07p . 22 4

# - /

# ~

1988 MILD ASTHMATICS SYMPTOMS FINAL SYM SCORES AFTE R Untreated CORRECTION FOR EQUAL

0 .6 ppm EXERCISE OR PRE-EXP SCOR S02 EXC SO 2 Subj . CT/SOB WHZ CT/SOB WHZ Subj . CT/SOB WHZ 297 0 5 5 0 297 0 5 584 10 10X 30 20 584 0 0 608 10 10 10X 20X 608 0 0 611 20 20 0 0 611 20 20 724 0 0 0 0 724 0 0 726 10 0 10 5 726 0 0 778 10 20 0 0 778 10 20 877 5 0 0 0 877 0 0 892 30 0 30 0 892 0 0 1024 20 30 5 0 1024 20 30 1028 10 0 5 0 1028 10 0 1045 30 30 20X 20X 1045 30 30 1096 5 0 0 0 1096 0 0 1153 20 20 5 10X 1153 20 20 1154 10 lUX u U 1154 10 0 1156 30 30 10 5 1156 30 30 1160 0 0 5 0 1160 0 0 1162 10X 5X 5 0 1162 10 0 1163 30 30 10 5 1163 30 30 1200 30 10 10 0 1200 30 10 X denotes instances where pre-exposure symptoms = post-exposure symptom s 

### Only looked at Post-Meds ("Card 5") (pre-exp) and Exercise ("Card 6") (post-exp) symptom score s Exp 7 - 0 .6 ppm, Untreated Exp 5 - Clean, Untreated 1988 MILDS SYMPTOMS 1988 MILD S 

### SYMPTOM COMPARISON METHOD 2 CT/SOB WHZ ANY S02 EX C 10+ 11/20 8/20 11/20 10+ 14/20 6/20

0 .55 0 .4 0 .55 0 .7 0 .3 20+ 7/20 7/20 8/20 20+ 9/20 2/2 0

0 .35 0 .35 0 .4 0 .45 0 .1p . 23 

# ,4-l /



### 1990 MODERATE ASTHMATIC SYMPTOMS FINAL 

### SYM SCORES AFTE R Low Meds CORRECTION FOR EQUAL

0 .6 ppm EXERC OR PRE-EXP SCORES S02 EXC S0 2 Subj . CT/SOB WHZ CT/SOB WHZ Subj . CT/SOB WHZ 1039 30 .00 30 .00 20X 20X 1039 30 .00 30 .00 1042 20 .00 20 .00 20 .00 0 .00 1042 0 .00 20 .00 1048 20 .00 0 .00 20 .00 0 .00 1048 0 .00 0 .00 1092 0 .00 5 .00 10X 5X 1092 0 .00 0 .00 1113 30 .00 20X 20 .00 10X 1113 30 .00 0 .00 1124 10 .00 10 .00 5 .00 0 .00 1124 10 .0t0 10 .00 1128 20 .00 10 .00 10 .00 0 .00 1128 20 . 40 10 .00 1133 20 .00 20 .00 5 .00 0 .00 1133 20 .00 20 .00 1139 10X 5 .00 0 .00 0 .00 1139 0 .00 0 .00 1195 30 .00 5 .00 5 .00 5 .00 1195 30 .00 0 .00 1197 30 .00 20 .00 20 .00 10X 1197 30 .00 20 .00 1199 30 .00 5 .00 L_ :, . ;, : 20 .00 1199 0 .00 0 .00 1201 10 .00 10 .00 10 .00 10X 1201 0 .00 0 .00 1202 40 .00 40 .00 10 .00 10 .00 1202 40 .00 40 .00 1203 40 .00 C .OC 30 .C0 C .CC '120- ~ C .CC 213 .00 1204 20 .00 20 .00 20X 20X 1204 0 .00 0 .00 1205 20 .00 20 .00 5 .00 0 .00 1205 20 .00 20 .00 1206 20 .00 10 .00 20X 20X 1206 0 .00 0 .00 1207 20 .00 20 .00 30 .00 30 .00 1207 0 .00 0 .00 1210 10 .00 10 .00 30 .00 30 .00 1210 0 .00 0 .00 1212 30 .00 30 .00 20 .00 20 .00 1212 30 .00 30 .00 X denotes instances where pre-exposure symptoms = post-exposure symptom s Only look at "30 Min Post Meds" ( pre-exp) and "40 Min Exer" (post-exp) Exp 1 - 0 .6 ppm, low Exp 7 - Clean, lo w 

### 1990 MED-DEP S 1990 MED-DEP SYMPTOMS SYMPTOM COMPARISON METHOD 2 0 .6 PPM SYMPTOM S CT/SOB WHZ ANY S02 EXC 10+ 11 / 21 10/21 12/21 10+ 19/21 10 121

0 .52 0 .48 0 .57 0 .90 0 .4 8 20+ 10/21 8/21 11 /21 20+ 16/21 8/2 1

0 .48 0 .38 0 .52 0 .76 0 .38

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