Federal Register / Vol. 79, No. 104 / Friday, May 30, 2014 / Notices 31111 

Oral Statements: In general, 

individuals or groups requesting to 

provide comments or oral presentation 

if appropriate at this public meeting will 

be limited to three minutes per speaker, 

subject to the number of people wanting 

to comment. Interested parties should 

contact the DFO in writing (preferably 

via email) at the contact information 

noted above by June 11, 2014 to be 

placed on the list of public speakers for 

the meeting. 

Written Statements: Written 

statements must be received by June 11, 

2014 so that the information may be 

made available to the Board for 

consideration. Written statements 

should be supplied to the DFO in the 

following formats: One hard copy with 

original signature and one electronic 

copy via email. Commenters are 

requested to provide two versions of 

each document submitted: One each 

with and without signatures because 

only documents without signatures may 

be published on the GLRI Web page. 

Accessibility: For information on 

access or services for individuals with 

disabilities, please contact the DFO at 

the phone number or email address 

noted above, preferably at least 10 days 

prior to the meeting, to give EPA as 

much time as possible to process your 

request. 

Dated: May 23, 2014. 

Cameron Davis, 

Senior Advisor to the Administrator. 

[FR Doc. 2014–12603 Filed 5–29–14; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

[EPA–HQ–OPP–2014–0331; FRL–9910–22] 

FIFRA Scientific Advisory Panel; 

Notice of Public Meeting 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Notice. 

SUMMARY: There will be a 3-day meeting 

of the Federal Insecticide, Fungicide, 

and Rodenticide Act Scientific Advisory 

Panel (FIFRA SAP) to consider and 

review New High Throughput Methods 

to Estimate Chemical Exposure. 

DATES: The meeting will be held on July 

29 to August 1, 2014, from 

approximately 9:00 a.m. to 5:00 p.m. 

Comments. The Agency encourages 

that written comments be submitted by 

July 15, 2014 and requests for oral 

comments be submitted by July 22, 

2014. However, written comments and 

requests to make oral comments may be 

submitted until the date of the meeting, 

but anyone submitting written 

comments after July 15, 2014 should 

contact the Designated Federal Official 

(DFO) listed under FOR FURTHER

INFORMATION CONTACT. For additional 

instructions, see Unit I.C. of the 

SUPPLEMENTARY INFORMATION. 

Nominations. Nominations of 

candidates to serve as ad hoc members 

of FIFRA SAP for this meeting should 

be provided on or before June 13, 2014. 

Webcast. This meeting may be 

webcast. Please refer to the FIFRA SAP’s 

Web site, http://www.epa.gov/scipoly/

sap for information on how to access the 

webcast. Please note that the webcast is 

a supplementary public process 

provided only for convenience. If 

difficulties arise resulting in webcasting 

outages, the meeting will continue as 

planned. 

Special accommodations. For 

information on access or services for 

individuals with disabilities, and to 

request accommodation of a disability, 

please contact the DFO listed under FOR

FURTHER INFORMATION CONTACT at least 

10 days prior to the meeting to give EPA 

as much time as possible to process 

your request. 

ADDRESSES: The meeting will be held at 

the Environmental Protection Agency, 

Conference Center, Lobby Level, One 

Potomac Yard (South Bldg.), 2777 

S. Crystal Dr., Arlington, VA 22202. 

Comments. Submit your comments, 

identified by docket identification (ID) 

number EPA–HQ–OPP–2014–0331, by 

one of the following methods: 

• Federal eRulemaking Portal: http:// 

www.regulations.gov. Follow the online 

instructions for submitting comments. 

Do not submit electronically any 

information you consider to be 

Confidential Business Information (CBI) 

or other information whose disclosure is 

restricted by statute. 

• Mail: OPP Docket, Environmental 

Protection Agency Docket Center (EPA/ 

DC) (28221T), 1200 Pennsylvania Ave. 

NW., Washington, DC 20460–0001. 

• Hand Delivery: To make special 

arrangements for hand delivery or 

delivery of boxed information, please 

follow the instructions at http://

www.epa.gov/dockets/contacts.htm. 

Additional instructions on commenting 

or visiting the docket, along with more 

information about dockets generally, is 

available at http://www.epa.gov/

dockets. 

If your comments contain any 

information that you consider to be CBI 

or otherwise protected, please contact 

the DFO listed under FOR FURTHER

INFORMATION CONTACT to obtain special 

instructions before submitting your 

comments. 

Nominations, requests to present oral 

comments, and requests for special 

accommodations. Submit nominations 

to serve as ad hoc members of FIFRA 

SAP, requests for special seating 

accommodations, or requests to present 

oral comments to the DFO listed under 

FOR FURTHER INFORMATION CONTACT. 

FOR FURTHER INFORMATION CONTACT: Fred 

Jenkins, DFO, Office of Science 

Coordination and Policy (7201M), 

Environmental Protection Agency, 1200 

Pennsylvania Ave. NW., Washington, 

DC 20460–0001; telephone number: 

(202) 564–3327; fax number: (202) 564– 

8382; email address: Jenkins.fred@

epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. General Information 

A. Does this action apply to me? 

This action is directed to the public 

in general. This action may, however, be 

of interest to persons who are or may be 

required to conduct testing of chemical 

substances under the Federal Food, 

Drug, and Cosmetic Act (FFDCA) and 

FIFRA. Since other entities may also be 

interested, the Agency has not 

attempted to describe all the specific 

entities that may be affected by this 

action. 

B. What should I consider as I prepare 

my comments for EPA? 

When submitting comments, 

remember to: 

1. Identify the document by docket ID 

number and other identifying 

information (subject heading, Federal 

Register date and page number). 

2. Follow directions. The Agency may 

ask you to respond to specific questions 

or organize comments by referencing a 

Code of Federal Regulations (CFR) part 

or section number. 

3. Explain why you agree or disagree; 

suggest alternatives and substitute 

language for your requested changes. 

4. Describe any assumptions and 

provide any technical information and/ 

or data that you used. 

5. If you estimate potential costs or 

burdens, explain how you arrived at 

your estimate in sufficient detail to 

allow for it to be reproduced. 

6. Provide specific examples to 

illustrate your concerns and suggest 

alternatives. 

7. Explain your views as clearly as 

possible, avoiding the use of profanity 

or personal threats. 

8. Make sure to submit your 

comments by the comment period 

deadline identified. 

mstockstill on DSK4VPTVN1PROD with NOTICES

31112 Federal Register / Vol. 79, No. 104 / Friday, May 30, 2014 / Notices 

C. How may I participate in this 

meeting? 

You may participate in this meeting 

by following the instructions in this 

unit. To ensure proper receipt by EPA, 

it is imperative that you identify docket 

ID number EPA–HQ–OPP–2014–0331 in 

the subject line on the first page of your 

request. 

1. Written comments. The Agency 

encourages that written comments be 

submitted, using the instructions in 

ADDRESSES, no later than July 15, 2014, 

to provide FIFRA SAP the time 

necessary to consider and review the 

written comments. Written comments 

are accepted until the date of the 

meeting, but anyone submitting written 

comments after July 15, 2014 should 

contact the DFO listed under FOR

FURTHER INFORMATION CONTACT. Anyone 

submitting written comments at the 

meeting should bring 30 copies for 

distribution to FIFRA SAP. 

2. Oral comments. The Agency 

encourages that each individual or 

group wishing to make brief oral 

comments to FIFRA SAP submit their 

request to the DFO listed under FOR

FURTHER INFORMATION CONTACT no later 

than July 22, 2014, in order to be 

included on the meeting agenda. 

Requests to present oral comments will 

be accepted until the date of the meeting 

and, to the extent that time permits, the 

Chair of FIFRA SAP may permit the 

presentation of oral comments at the 

meeting by interested persons who have 

not previously requested time. The 

request should identify the name of the 

individual making the presentation, the 

organization (if any) the individual will 

represent, and any requirements for 

audiovisual equipment (e.g., overhead 

projector, 35 mm projector, chalkboard). 

Oral comments before FIFRA SAP are 

limited to approximately 5 minutes 

unless prior arrangements have been 

made. In addition, each speaker should 

bring 30 copies of his or her comments 

and presentation slides for distribution 

to the FIFRA SAP at the meeting. 

3. Seating at the meeting. Seating at 

the meeting will be open and on a firstcome basis. 

4. Request for nominations to serve as 

ad hoc members of FIFRA SAP for this 

meeting. As part of a broader process for 

developing a pool of candidates for each 

meeting, FIFRA SAP staff routinely 

solicits the stakeholder community for 

nominations of prospective candidates 

for service as ad hoc members of FIFRA 

SAP. Any interested person or 

organization may nominate qualified 

individuals to be considered as 

prospective candidates for a specific 

meeting. Individuals nominated for this 

meeting should have expertise in one or 

more of the following areas: 

Computational exposure modeling, 

Mathematical modeling of 

environmental and biological systems 

and their interactions, Toxicokinetics, 

Pharmacokinetics, Environmental fate 

and transport, Modeling of chemical 

concentrations in water sources, 

Bioinformatics, Biomathematics, 

Statistics, Environment and health risk/ 

impact assessment, including 

vulnerable and/or susceptible 

populations, Ecological risk assessment, 

Human exposure assessment, Ecological 

exposure assessment, Pharma, 

Monitoring of environmental 

contaminants—surface water and 

groundwater. Note: In support of the US 

Environmental Protection Agency’s 

(EPA) priority of ‘‘Making a Visible 

Difference in Communities’’ across the 

country, the Agency is committed to 

helping minority, low-income, tribal 

and other vulnerable populations 

improve their health and environment. 

In an effort to ensure that actions being 

proposed by the agency are taking into 

consideration input from potential 

communities with environmental justice 

concerns, the EPA is offering an 

opportunity to provide input on the 

FIFRA SAP meeting to address scientific 

issues associated with ‘‘New High 

Throughput Methods to Estimate 

Chemical Exposure’’. The EPA 

encourages all grass-root organizations 

and residents to submit public 

comments on this issue which is being 

addressed during the FIFRA Scientific 

Advisory Panel meeting. The Agency 

also encourages community 

environmental justice advocates to give 

a voice to their communities by 

nominating candidates for consideration 

to serve on this panel. 

Nominees should be scientists who 

have sufficient professional 

qualifications, including training and 

experience, to be capable of providing 

expert comments on the scientific issues 

for this meeting. Nominees should be 

identified by name, occupation, 

position, address, and telephone 

number. Nominations should be 

provided to the DFO listed under FOR

FURTHER INFORMATION CONTACT on or 

before June 13, 2014. The Agency will 

consider all nominations of prospective 

candidates for this meeting that are 

received on or before this date. 

However, final selection of ad hoc 

members for this meeting is a 

discretionary function of the Agency. 

The selection of scientists to serve on 

FIFRA SAP is based on the function of 

the panel and the expertise needed to 

address the Agency’s charge to the 

panel. No interested scientists shall be 

ineligible to serve by reason of their 

membership on any other advisory 

committee to a Federal department or 

agency or their employment by a 

Federal department or agency except the 

EPA. Other factors considered during 

the selection process include 

availability of the potential panel 

member to fully participate in the 

panel’s reviews, absence of any conflicts 

of interest or appearance of lack of 

impartiality, independence with respect 

to the matters under review, and lack of 

bias. Although financial conflicts of 

interest, the appearance of lack of 

impartiality, lack of independence, and 

bias may result in disqualification, the 

absence of such concerns does not 

assure that a candidate will be selected 

to serve on FIFRA SAP. Numerous 

qualified candidates are identified for 

each panel. Therefore, selection 

decisions involve carefully weighing a 

number of factors including the 

candidates’ areas of expertise and 

professional qualifications and 

achieving an overall balance of different 

scientific perspectives on the panel. In 

order to have the collective breadth of 

experience needed to address the 

Agency’s charge for this meeting, the 

Agency anticipates selecting 

approximately 11 ad hoc scientists. 

FIFRA SAP members are subject to 

the provisions of 5 CFR part 2634, 

Executive Branch Financial Disclosure, 

as supplemented by the EPA in 5 CFR 

part 6401. In anticipation of this 

requirement, prospective candidates for 

service on the FIFRA SAP will be asked 

to submit confidential financial 

information which shall fully disclose, 

among other financial interests, the 

candidate’s employment, stocks and 

bonds, and where applicable, sources of 

research support. The EPA will evaluate 

the candidates financial disclosure form 

to assess whether there are financial 

conflicts of interest, appearance of a 

lack of impartiality or any prior 

involvement with the development of 

the documents under consideration 

(including previous scientific peer 

review) before the candidate is 

considered further for service on FIFRA 

SAP. Those who are selected from the 

pool of prospective candidates will be 

asked to attend the public meetings and 

to participate in the discussion of key 

issues and assumptions at these 

meetings. In addition, they will be asked 

to review and to help finalize the 

meeting minutes. The list of FIFRA SAP 

members participating at this meeting 

will be posted on the FIFRA SAP Web 

site at http://www.epa.gov/scipoly/sap 

or may be obtained from the OPP Docket 

or at http://www.regulations.gov. 

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Federal Register / Vol. 79, No. 104 / Friday, May 30, 2014 / Notices 31113 

II. Background 

A. Purpose of FIFRA SAP 

FIFRA SAP serves as the primary 

scientific peer review mechanism of 

EPA’s Office of Chemical Safety and 

Pollution Prevention (OCSPP) and is 

structured to provide scientific advice, 

information and recommendations to 

the EPA Administrator on pesticides 

and pesticide-related issues as to the 

impact of regulatory actions on health 

and the environment. FIFRA SAP is a 

Federal advisory committee established 

in 1975 under FIFRA that operates in 

accordance with requirements of the 

Federal Advisory Committee Act. FIFRA 

SAP is composed of a permanent panel 

consisting of seven members who are 

appointed by the EPA Administrator 

from nominees provided by the National 

Institutes of Health and the National 

Science Foundation. FIFRA established 

a Science Review Board consisting of at 

least 60 scientists who are available to 

the SAP on an ad hoc basis to assist in 

reviews conducted by the SAP. As a 

peer review mechanism, FIFRA SAP 

provides comments, evaluations and 

recommendations to improve the 

effectiveness and quality of analyses 

made by Agency scientists. Members of 

FIFRA SAP are scientists who have 

sufficient professional qualifications, 

including training and experience, to 

provide expert advice and 

recommendation to the Agency. 

B. Public Meeting 

EPA has made many recent advances 

in high throughput bioactivity testing. 

However, concurrent advances in rapid, 

quantitative prediction of human and 

ecological exposures have been lacking, 

despite the clear importance of both 

measures for a risk-based approach to 

prioritizing and screening chemicals. A 

recent report by the National Research 

Council of the National Academies, 

Exposure Science in the 21st Century: A 

Vision and a Strategy (NRC 2012) laid 

out a number of applications in 

chemical evaluation of both toxicity and 

risk in critical need of quantitative 

exposure predictions, including 

screening and prioritization of 

chemicals for targeted toxicity testing, 

focused exposure assessments or 

monitoring studies, and quantification 

of population vulnerability. Despite 

these significant needs, for the majority 

of chemicals (e.g. non-pesticide 

environmental compounds) there are no 

or limited estimates of exposure. For 

example, exposure estimates exist for 

only 7% of the ToxCast Phase II 

chemical list. In addition, the data 

required for generating exposure 

estimates for large numbers of chemicals 

is severely lacking (Egeghy et al. 2012). 

This SAP will review the use of EPA’s 

ExpoCast model to rapidly estimate 

potential chemical exposures for 

prioritization and screening purposes. 

The focus will be on bounded chemical 

exposure values for people and the 

environment for the Endocrine 

Disruptor Screening Program (EDSP) 

Universe of Chemicals. In addition to 

exposure, the SAP will review methods 

to extrapolate an in vivo dose from in 

vitro dose data. This will involve 

presenting pharmacokinetic (PK) data 

for chemicals that have been run 

through a battery of high throughput 

endocrine screening assays and the 

methodology to use that PK information 

to estimate an in vivo dose. This 

exposure and RTK information along 

with high throughput in vitro bioactivity 

data will allow the EPA to assign a risk 

ranking to chemicals and prioritize 

them accordingly. 

ExpoCast is an EPA initiative to 

develop the necessary approaches and 

tools for rapidly prioritizing and 

screening thousands of chemicals based 

on the potential for human exposure. 

This focus for ExpoCast is distinct from 

many existing exposure tools that 

support regulatory risk assessment. 

Traditional exposure tools are lower 

throughput, requiring considerable data 

to make predictions of sufficient 

precision for a full risk assessment. 

ExpoCast efforts have focused on 

empirically assessing the uncertainty in 

forecasts made with limited available 

data, finding that in some cases even 

highly uncertain forecasts may be useful 

for prioritization and screening. 

In order to relate high throughput 

bioactivity data and rapid exposure 

predictions, an in vitro-in vivo 

extrapolation (IVIVE) via PK is needed. 

This IVIVE relates the in vitro 

compound concentrations (mM) found to 

be bioactive to the in vivo doses needed 

to produce serum concentrations equal 

to the in vitro concentrations. Without 

the time and resources necessary to 

generate in vivo PK data for the 

thousands of chemicals in the EDSP 

universe, high throughput 

pharmacokinetics (HTPK) can serve as a 

useful surrogate. HTPK methods were 

developed for pharmaceuticals to 

estimate therapeutic doses for clinical 

studies. HTPK technologies have been 

effective for pharmaceutical compounds 

and predicted concentrations are 

typically on the order of the measured 

in vivo concentrations. For nontherapeutic compounds in humans, PK 

data is not available and so it is 

essential to carefully characterize the 

predictive ability of the HTPK models 

and define the domain of applicability. 

High throughput exposure prediction 

and high throughput PK, when taken 

together with in vitro bioactivity 

profiling as a surrogate for hazard, will 

allow for a risk-based, rapid 

prioritization and screening of 

chemicals in the EDSP universe and 

beyond. 

C. FIFRA SAP Documents and Meeting 

Minutes 

EPA’s background paper, related 

supporting materials, charge/questions 

to FIFRA SAP, FIFRA SAP composition 

(i.e., members and ad hoc members for 

this meeting), and the meeting agenda 

will be available by approximately July 

9, 2014. In addition, the Agency may 

provide additional background 

documents as the materials become 

available. You may obtain electronic 

copies of these documents, and certain 

other related documents that might be 

available electronically, at http://

www.regulations.gov and the FIFRA 

SAP homepage at http://www.epa.gov/

scipoly/sap. 

FIFRA SAP will prepare meeting 

minutes summarizing its 

recommendations to the Agency 

approximately 90 days after the 

meeting. The meeting minutes will be 

posted on the FIFRA SAP Web site or 

may be obtained from the OPP Docket 

or at http://www.regulations.gov. 

List of Subjects 

Environmental protection, Pesticides 

and pests, Environmental justice. 

Dated: May 20, 2014. 

David J. Dix, 

Director, Office of Science Coordination and 

Policy. 

[FR Doc. 2014–12593 Filed 5–29–14; 8:45 am] 

BILLING CODE 6560–50–P 

FEDERAL RESERVE SYSTEM 

Change in Bank Control Notices; 

Acquisitions of Shares of a Bank or 

Bank Holding Company 

The notificants listed below have 

applied under the Change in Bank 

Control Act (12 U.S.C. 1817(j)) and 

§ 225.41 of the Board’s Regulation Y (12 

CFR 225.41) to acquire shares of a bank 

or bank holding company. The factors 

that are considered in acting on the 

notices are set forth in paragraph 7 of 

the Act (12 U.S.C. 1817(j)(7)). 

The notices are available for 

immediate inspection at the Federal 

Reserve Bank indicated. The notices 

also will be available for inspection at 

the offices of the Board of Governors. 

mstockstill on DSK4VPTVN1PROD with NOTICES