# Support Documents for Significant New Use Rules (SNUR) on Premanufacture Notices (PMN) P-07-537

EPA Docket EPA-HQ-OPPT-2012-0182

# Index A-001 Structure Activity Team (SAT) Report for PMN P-07-537 A-002 Initial Review Engineering Report for PMN P-07-537 A-003 Initial Review Exposure Report for PMN P-07-537 A-004 TSCA Section 5(e) Consent Order and Determinations Supporting Consent Order for PMN P-07-537

# A-001 Structure Activity Team (SAT) Report for PMN P-07-537- "-

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### STRUCTURE ACTIVITY TEAM REPORT ver. 04198

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### ICa!,e #: P-07 -0537 Date: 

### 7/20/2007 Chair:

Name:

RN; Name:

!Molecullar Fonnula; 1------ I



### L. Keifer



### Related 

### Case Numbers Case Role Role

Page of

### STRUCTURE ACTIVITY TEAM REPORT CASE NUMBER: P07-0537 

### RELATED CASES: CONCLUSIONS/DISCUSSIONS TYPE'OF CONCERN: LEVEL OF CONCERN: KEYWORDS: ACUTE NEURO AQUATOX SUMMARY OF ASSESSMENT HEALTH 2-3 07/20/07

ECOTOX 2



### HEALTH: Not expected to be absorbed through the skin as the neat material, absorbed through the skin if in solution (pchem), absorbed from the lung and GI tract (analog); the PMN substance is expected to release metabolically; Concern for acute toxicity and neurotoxicity based on submitted test data. *CEB HEALTH: Moderate high concern (Dermal, inhalation); 'XB: Testing desired '

### ECOTOX: Predicted (p) and measured (M) toxicity values in mg/L (ppm) are: fish 96-h LC50 > 100.0 P daphnid48-hLC50 >100.0 P green algal 96-h EC50 c > 100.0 P fish chronic value > 10.0 P fish ChV7.0 P daphnid ChV > 10.0 P algal ChV > 10.0 P Predictions are based on SARs for ; SAR chemical class 

## = ; MW148; effective concentrations based on 100% active ingredients and nominal concentrations; hardness <150.0 mg/L as CaC03; and TOC <2.0 mg/L; moderate concern for toxicity assesSment factor = 

### 10.0 concern concentration 0.700 mg/L (ppm) *CEB ECOTOX: All releases to water with CC XB: testing desired SAT Co-chair: Leonard Keifer 564-8916

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, NCSAB SAT REPORT

PMN: P-07-0537 ICAS RN: I 

### .' Chemical Name: Analogs:

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# t,Toxicology Report

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Test Conditions Rcvd: 7/3/2007


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### Pi()Y.,Q537 CAS No. Rcvd: 7/3/2007 OECD Completed ID: Rec# 4 893 

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# A-002 Initial Review Engineering Report for PMN P-07-537

### INITIAL REVIEW ENGINEERING REPORT PMN: 07-0537 Focus Ready Draft 7/26/2007 ENGINEER: Arnold \ DGR PV (kg/yr):

SUBMITTER: USE:

OTHER USES:

CRSS (07/19/2007):

### Consumer Use: No SAT (concerns) (07/20/2007): Migration to groundwater: Rapid PBT rating: P2B1T1 Health: 2-3 Dermal, Inhalation, XB Testing (Testing desired) Eco: 2 Water (All releases to water), XB Testing (Testing desired) OCCUPATIONAL EXPOSURE RATING: 2-3B NOTES & KEY ASSUMPTIONS: Generated by the 06/07/2005 version of ChemSTEER.

POLLUTION PREVENTION CONSIDERATIONS: P2 Claim:

EXPOSURE-BASED REVIEW:

INITIAL REVIEW ENGINEERING REPORT PMN: 07-0537

### ENVIRONMENTAL RELEASES ESTIMATE SUMMARY IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources to the same medium.

### OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

Inhalation:

Dermal:

INITIAL REVIEW ENGINEERING REPORT PMN: 07-0537

ENVIRONMENTAL RELEASES ESTIMATE SUMMARY IRER Note: The daily releases listed for any source below may coincide with daily releases from the other sources to the same

### medium.

OCCUPATIONAL EXPOSURES ESTIMATE SUMMARY

### MEMORANDUM of CBI TELEPHONE CONVERSATION

# A-003 Initial Review Exposure Report for PMN P-07-537Page of INITIAL REVIEW EXPOSURE REPORT Case Number: P070537 Assessor: ENVIRONMENTAL RELEASES Scenario#: 1 Number of Release Sites: Release Activity: Release Description: WATER LANDFILL INCINER LAND/INCIN FUGITIVE Total Releases: (kg/yr) (kg/yr) (kg/yr) (kg/yr) (kg/yr) Release Days/yr: Per Site Release: (kg/day) (kg/yr) (kg/yr) (kg/yr) (kg/day) Remarks:

Consumer use expected? No, consumer use is not expected.

Parameter Exp Based Persistent Exceedance value Drinking (Surface) Water Dose (mg/kg/day) Yes N/A Fish Ingestion Dose (mg/kg/day) Yes N/A Inhalation Dose (mg/kg/day) Yes N/A Groundwater Dose (mg/kg/day) Yes N/A Surface Water Release after treatment (kg/yr) Yes N/A Total Release After Treatment (kg/yr) Yes N/A Consumer Exposure Dose? No

FATE TESTING RECOMMENDATION: Porous Pot (OECD 303A)INITIAL REVIEW EXPOSURE REPORT Page of CASE NUMBER:P070537 SIC-CODE BASED HUMAN AND AQUATIC EXPOSURES TO SURFACE WATER RELEASES SCENARIO #:1 RELEASE ACTIVITY:Manufacturing & Use SIC-CODE DESCRIPTION SIC-CODE (S) EXPOSED POPULATION:Adult
WASTE WATER TREATMENT REMOVAL (%) COC (μg/L) RELEASE DAYS PRE-TREATMENT RELEASE

(kg/day) POST-TREATMENT RELEASE

(kg/day) BCF (L/kg) 20. 700.00 3.16 AQUATIC EXPOSURE ESTIMATES - SURFACE WATER PLANT TYPE % ILE FACILITY STREAM FLOW (MLD) STREAM CONC. ( μ g/l) Harmonic

MEAN 30Q5 7Q10 1Q10 Harmonic MEAN 30Q5 7Q10 1Q10 ALL 50 311.58 116.44 75.70 61.91 426.21 1140.50 1754.29 2145.05 ALL 10 32.75 11.98 7.19 5.98 4054.96 1.11E+04 1.85E+04 2.22E+04

DRINKING WATER AND FISH INGESTION EXPOSURE ESTIMATES Exposure Units Drinking Water Results Drinking Water Units Fish Ingestion Results Fish Ingestion

Units
Cancer LADD pot mg/kg/day mg/kg/day LADC pot mg/L mg/kg Chronic Non-Cancer ADD pot mg/kg/day mg/kg/day ADC pot mg/L mg/kg Acute ADR pot mg/kg/day mg/kg/dayINITIAL REVIEW EXPOSURE REPORT Page of CASE NUMBER: P070537
SIC CODE EXPOSURES TO SURFACE WATER RELEASES

SCENARIO #: 1 RELEASE ACTIVITY: Manufacturing & Use SIC CODE DESCRIPTION ASSOCIATED SIC CODES: SIC CODE RESULTS COC ( μ g/L) % yr exceeded Days/yr exceeded Release days/year Loading (kg/site/day) Waste Water Treatment (%) High/Avg Analysis 700.00 20.00

REMARKINITIAL REVIEW EXPOSURE REPORT Page of CASE NUMBER:P070537
DRINKING WATER EXPOSURE ESTIMATES FROM LANDFILL RELEASES SCENARIO #:1 ACTIVITY RELEASE DESCRIPTION: EXPOSED POPULATION:Adult

NUMBER OF SITES LANDFILL RELEASE (kg/yr) LANDFILLED SLUDGE (kg/yr) MIGRATION FACTOR 1 DRINKING WATER TREATMENT (%)

Exposure Units Results ASSUMPTIONS ED (years) AT (years) BW (kg) IR (L/day) Cancer LADD pot (mg/kg/day) LADC pot (mg/L) Chronic Non-Cancer ADD pot (mg/kg/day) ADC pot (mg/L)INITIAL REVIEW EXPOSURE REPORT Page of CASE NUMBER:P070537
INHALATION EXPOSURE ESTIMATES FROM FUGITIVE RELEASES

SCENARIO #:1 RELEASE ACTIVITY RELEASE DESCRIPTION: METHOD OF CALCULATION EXPOSED POPULATION:Adult
NUMBER OF SITES % TREATMENT TYPE OF REMOVAL PRE-TREAT RELEASE (kg/yr) POST-TREAT RELEASE (kg/yr)

Exposure Units Results ASSUMPTIONS ED (years) AT (years) BW (kg) Inh. Rate (m 3 /hr) Cancer LADD pot (mg/kg/day) LADC pot (mg/m 3 ) Chronic Non-Cancer ADD pot (mg/kg/day) ADC pot (mg/m 3 )

# A-004 TSCA Section 5(e) Consent Order and Determinations Supporting Consent Order for PMN P-07-537