Federal Register / Vol. 89, No. 188 / Friday, September 27, 2024 / Proposed Rules 79203 

and of itself create any new 

requirements, but rather results in the 

applicability of requirements contained 

in the CAA for areas that have been 

redesignated to attainment. In addition, 

the Administrator is required to approve 

a SIP submission that complies with the 

provisions of the Clean Air Act and 

applicable Federal regulations. 42 

U.S.C. 7410(k); 40 CFR 52.02(a). Thus, 

in reviewing SIP submissions, the EPA’s 

role is to approve state choices, 

provided that they meet the criteria of 

the Clean Air Act. Accordingly, this 

action merely proposes to approve state 

law as meeting Federal requirements 

and does not impose additional 

requirements beyond those imposed by 

state law. For these reasons, this 

proposed action: 

• Is not a significant regulatory action 

subject to review by the Office of 

Management and Budget under 

Executive Orders 12866 (58 FR 51735, 

October 4, 1993) and 14094 (88 FR 

21879, April 11, 2023); 

• Does not impose an information 

collection burden under the provisions 

of the Paperwork Reduction Act (44 

U.S.C. 3501 et seq.); 

• Is certified as not having a 

significant economic impact on a 

substantial number of small entities 

under the Regulatory Flexibility Act (5 

U.S.C. 601 et seq.); 

• Does not contain any unfunded 

mandate or significantly or uniquely 

affect small governments, as described 

in the Unfunded Mandates Reform Act 

of 1995 (Pub. L. 104–4); 

• Does not have federalism 

implications as specified in Executive 

Order 13132 (64 FR 43255, August 10, 

1999); 

• Is not subject to Executive Order 

13045 (62 FR 19885, April 23, 1997) 

because it approves a state program; 

• Is not a significant regulatory action 

subject to Executive Order 13211 (66 FR 

28355, May 22, 2001); and 

• Is not subject to requirements of 

Section 12(d) of the National 

Technology Transfer and Advancement 

Act of 1995 (15 U.S.C. 272 note) because 

application of those requirements would 

be inconsistent with the Clean Air Act. 

In addition, this proposed action, 

pertaining to redesignation of the 

Whatcom County (partial) SO2

nonattainment area and approval of a 

maintenance plan for the area, would 

not be approved to apply on any Indian 

reservation land or in any other area 

where the EPA or an Indian Tribe has 

demonstrated that a Tribe has 

jurisdiction. In those areas of Indian 

country, the rule would not have Tribal 

implications and would not impose 

substantial direct costs on tribal 

governments or preempt Tribal law as 

specified by Executive Order 13175 (65 

FR 67249, November 9, 2000). 

Consistent with EPA policy, the EPA 

provided a consultation opportunity to 

Tribes located near the nonattainment 

area, in letters dated July 25, 2024 and 

July 29, 2024, included in the docket for 

this action. 

Executive Order 12898 (Federal 

Actions to Address Environmental 

Justice in Minority Populations and 

Low-Income Populations, 59 FR 7629, 

February 16, 1994) directs Federal 

agencies to identify and address 

‘‘disproportionately high and adverse 

human health or environmental effects’’ 

of their actions on communities with 

environmental justice (EJ) concerns to 

the greatest extent practicable and 

permitted by law. The EPA defines EJ as 

‘‘the fair treatment and meaningful 

involvement of all people regardless of 

race, color, national origin, or income 

with respect to the development, 

implementation, and enforcement of 

environmental laws, regulations, and 

policies.’’ The EPA further defines the 

term fair treatment to mean that ‘‘no 

group of people should bear a 

disproportionate burden of 

environmental harms and risks, 

including those resulting from the 

negative environmental consequences of 

industrial, governmental, and 

commercial operations or programs and 

policies.’’ 

The Washington Department of 

Ecology did evaluate environmental 

justice considerations as part of its SIP 

submittal; the CAA and applicable 

implementing regulations neither 

prohibit nor require such an evaluation. 

The EPA did not perform an EJ analysis 

and did not consider EJ in this action. 

Consideration of EJ is not required as 

part of this action, and there is no 

information in the record inconsistent 

with the stated goal of Executive Order 

12898 of achieving environmental 

justice for communities with EJ 

concerns. 

List of Subjects in 40 CFR Part 52 

Environmental protection, Air 

pollution control, Incorporation by 

reference, Intergovernmental relations, 

Ozone, Particulate matter, Reporting 

and recordkeeping requirements, Sulfur 

oxides, Volatile organic compounds. 

Authority: 42 U.S.C. 7401 et seq. 

Dated: September 19, 2024. 

Casey Sixkiller, 

Regional Administrator, Region 10. 

[FR Doc. 2024–22171 Filed 9–26–24; 8:45 am] 

BILLING CODE 6560–50–P 

ENVIRONMENTAL PROTECTION 

AGENCY 

40 CFR Part 721 

[EPA–HQ–OPPT–2021–0221; FRL–12141– 

01–OCSPP] 

RIN 2070–AB27 

Significant New Use Rules on Certain 

Chemical Substances (21–3.F) 

AGENCY: Environmental Protection 

Agency (EPA). 

ACTION: Proposed rule. 

SUMMARY: EPA is proposing significant 

new use rules (SNURs) under the Toxic 

Substances Control Act (TSCA) for 

chemical substances that were the 

subject of premanufacture notices 

(PMNs). The chemical substances 

received ‘‘not likely to present an 

unreasonable risk’’ determinations 

pursuant to TSCA. The SNURs require 

persons who intend to manufacture 

(defined by statute to include import) or 

process any of these chemical 

substances for an activity that is 

proposed as a significant new use by 

this rulemaking to notify EPA at least 90 

days before commencing that activity. 

The required notification initiates EPA’s 

evaluation of the conditions of use for 

that chemical substance. In addition, the 

manufacture or processing for the 

significant new use may not commence 

until EPA has conducted a review of the 

required notification, made an 

appropriate determination regarding 

that notification, and taken such actions 

as required by that determination. 

DATES: Comments must be received on 

or before October 28, 2024. 

ADDRESSES: Submit your comments, 

identified by docket identification (ID) 

number EPA–HQ–OPPT–2021–0221, at 

https://www.regulations.gov. Follow the 

online instructions for submitting 

comments. Do not submit electronically 

any information you consider to be 

Confidential Business Information (CBI) 

or other information whose disclosure is 

restricted by statute. Additional 

instructions on commenting and visiting 

the docket, along with more information 

about dockets generally, is available at 

https://www.epa.gov/dockets. 

FOR FURTHER INFORMATION CONTACT: 

For technical information: William 

Wysong, New Chemicals Division 

(7405M), Office of Pollution Prevention 

and Toxics, Environmental Protection 

Agency, 1200 Pennsylvania Ave. NW, 

Washington, DC 20460–0001; telephone 

number: (202) 564–4163; email address: 

wysong.william@epa.gov. 

For general information: The TSCAHotline, ABVI-Goodwill, 422 South 


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Clinton Ave., Rochester, NY 14620; 

telephone number: (202) 554–1404; 

email address: TSCA-Hotline@epa.gov. 

SUPPLEMENTARY INFORMATION: 

I. Executive Summary 

A. What is the Agency’s authority for 

taking this action? 

TSCA section 5(a)(2) (15 U.S.C. 

2604(a)(2)) authorizes EPA to determine 

that a use of a chemical substance is a 

‘‘significant new use.’’ EPA must make 

this determination by rule after 

considering all relevant factors, 

including the factors in TSCA section 

5(a)(2) (see also the discussion in Unit 

II.). 

B. What action is the Agency taking? 

EPA is proposing SNURs for the 

chemical substances discussed in Unit 

III. These SNURs, if finalized as 

proposed, would require persons who 

intend to manufacture or process any of 

these chemical substances for an 

activity that is designated as a 

significant new use to notify EPA at 

least 90 days before commencing that 

activity. 

C. Does this action apply to me? 

1. General Applicability 

This action applies to you if you 

manufacture, process, or use the 

chemical substances identified in Unit 

III. This may include entities in North 

American Industrial Classification 

System (NAICS) codes 325 and 324110, 

e.g., chemical manufacturing and 

petroleum refineries. 

2. Applicability to Importers and 

Exporters 

This action may also apply to certain 

entities through pre-existing import 

certification and export notification 

requirements under TSCA (https://

www.epa.gov/tsca-import-exportrequirements). 

Chemical importers are subject to 

TSCA section 13 (15 U.S.C. 2612), the 

requirements promulgated at 19 CFR 

12.118 through 12.127 (see also 19 CFR 

127.28), and the EPA policy in support 

of import certification at 40 CFR part 

707, subpart B. Chemical importers 

must certify that the shipment of the 

chemical substance complies with all 

applicable rules and orders under 

TSCA, including regulations issued 

under TSCA sections 5, 6, 7 and Title 

IV. 

Pursuant to 40 CFR 721.20, any 

persons who export or intend to export 

a chemical substance that is the subject 

of this proposed rule on or after October 

28, 2024 are subject to the export 

notification provisions of TSCA section 

12(b) (15 U.S.C. 2611(b)) and must 

comply with the export notification 

requirements in 40 CFR part 707, 

subpart D. 

D. What are the incremental economic 

impacts of this action? 

EPA has evaluated the potential costs 

of establishing SNUN reporting 

requirements for potential 

manufacturers (including importers) 

and processors of the chemical 

substances subject to these proposed 

SNURs. This analysis, which is 

available in the docket, is briefly 

summarized here. 

1. Estimated Costs for SNUN 

Submissions 

If a SNUN is submitted, costs are an 

estimated $45,000 per SNUN 

submission for large business submitters 

and $14,500 for small business 

submitters. These estimates include the 

cost to prepare and submit the SNUN 

(including registration for EPA’s Central 

Data Exchange (CDX)), and the payment 

of a user fee. Businesses that submit a 

SNUN would be subject to either a 

$37,000 user fee required by 40 CFR 

700.45(c)(2)(ii) and (d), or, if they are a 

small business as defined at 13 CFR 

121.201, a reduced user fee of $6,480 

(40 CFR 700.45(c)(1)(ii) and (d)) per 

fiscal year 2022. The costs of 

submission for SNUNs will not be 

incurred by any company unless a 

company decides to pursue a significant 

new use as defined in these SNURs. 

Additionally, these estimates reflect the 

costs and fees as they are known at the 

time of this rulemaking. 

2. Estimated Costs for Export 

Notifications 

EPA has also evaluated the potential 

costs associated with the export 

notification requirements under TSCA 

section 12(b) and the implementing 

regulations at 40 CFR part 707, subpart 

D. For persons exporting a substance 

that is the subject of a SNUR, a one-time 

notice to EPA must be provided for the 

first export or intended export to a 

particular country. The total costs of 

export notification will vary by 

chemical, depending on the number of 

required notifications (i.e., the number 

of countries to which the chemical is 

exported). While EPA is unable to make 

any estimate of the likely number of 

export notifications for the chemical 

substances covered by these SNURs, as 

stated in the accompanying economic 

analysis, the estimated cost of the export 

notification requirement on a per unit 

basis is approximately $106. 

E. What should I consider as I prepare 

my comments for EPA? 

1. Submitting CBI 

Do not submit CBI to EPA through 

email or https://www.regulations.gov. If 

you wish to include CBI in your 

comment, please follow the applicable 

instructions at https://www.epa.gov/ 

dockets/commenting-epa-dockets#rules 

and clearly mark the information that 

you claim to be CBI. Information so 

marked will not be disclosed except in 

accordance with procedures set forth in 

40 CFR parts 2 and 703. 

2. Tips for Preparing Your Comments 

When preparing and submitting your 

comments, see the commenting tips at 

https://www.epa.gov//epa-dockets. 

II. Background 

This unit provides general 

information about SNURs. For 

additional information about EPA’s new 

chemical program go to https://

www.epa.gov/reviewing-new-chemicalsunder-toxic-substances-control-act-tsca. 

A. Significant New Use Determination 

Factors 

TSCA section 5(a)(2) states that EPA’s 

determination that a use of a chemical 

substance is a significant new use must 

be made after consideration of all 

relevant factors, including: 

• The projected volume of 

manufacturing and processing of a 

chemical substance. 

• The extent to which a use changes 

the type or form of exposure of human 

beings or the environment to a chemical 

substance. 

• The extent to which a use increases 

the magnitude and duration of exposure 

of human beings or the environment to 

a chemical substance. 

• The reasonably anticipated manner 

and methods of manufacturing, 

processing, distribution in commerce, 

and disposal of a chemical substance. 

In determining what would constitute 

a significant new use for the chemical 

substances that are the subject of these 

SNURs, EPA considered relevant 

information about the toxicity of the 

chemical substances, and potential 

human exposures and environmental 

releases that may be associated with the 

substances, in the context of the four 

bulleted TSCA section 5(a)(2) factors 

listed in this unit and discussed in Unit 

III. 

These proposed SNURs include PMN 

substances that received a ‘‘not likely to 

present an unreasonable risk’’ 

determination in TSCA section 

5(a)(3)(c). During its review of these 

chemicals, EPA identified certain 


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conditions of use that are not intended 

by the submitters, EPA is proposing to 

designate those conditions of use as new 

uses. 

B. Rationale and Objectives of the 

SNURs 

1. Rationale 

Under TSCA, no person may 

manufacture a new chemical substance 

or manufacture or process a chemical 

substance for a significant new use until 

EPA makes a determination as described 

in TSCA section 5(a) and takes any 

required action. The issuance of a SNUR 

is not a risk determination itself, only a 

notification requirement for ‘‘significant 

new uses,’’ so that the Agency has the 

opportunity to review the SNUN for the 

significant new use and make a TSCA 

section 5(a)(3) risk determination. 

During review of the PMNs submitted 

for the chemical substances that are the 

subject of these proposed SNURs and as 

further discussed in Unit III., EPA 

identified certain other conditions of 

use, in addition to those conditions of 

use intended by the submitter. EPA has 

determined that the chemical under the 

conditions of use is not likely to present 

an unreasonable risk. However, EPA has 

not assessed risks associated with 

certain conditions of use. EPA is 

proposing to designate these other 

circumstances of use as significant new 

uses. As a result, those significant new 

uses cannot occur without going 

through a separate, subsequent EPA 

review and determination process 

associated with a SNUN. 

2. Objectives 

EPA is proposing these SNURs 

because the Agency wants: 

• To be able to complete its review 

and determination on each of the PMN 

substances, while deferring analysis on 

the significant new uses proposed in 

these rules unless and until the Agency 

receives a SNUN. 

• To have an opportunity to review 

and evaluate data submitted in a SNUN 

before the submitter begins 

manufacturing or processing a listed 

chemical substance for the described 

significant new use. 

• To be obligated to make a 

determination under TSCA section 

5(a)(3) regarding the use described in 

the SNUN, under the conditions of use. 

The Agency will either determine under 

TSCA section 5(a)(3)(C) that the 

significant new use is not likely to 

present an unreasonable risk, including 

an unreasonable risk to a potentially 

exposed or susceptible subpopulation 

identified as relevant by the 

Administrator under the conditions of 

use, or make a determination under 

TSCA section 5(a)(3)(A) or (B) and take 

the required regulatory action associated 

with the determination, before 

manufacture or processing for the 

significant new use of the chemical 

substance can occur. 

Issuance of a proposed SNUR for a 

chemical substance does not signify that 

the chemical substance is listed on the 

TSCA Chemical Substance Inventory 

(TSCA Inventory). Guidance on how to 

determine if a chemical substance is on 

the TSCA Inventory is available at 

https://www.epa.gov/tsca-inventory. 

C. Significant New Uses Claimed as CBI 

EPA is proposing to establish certain 

significant new uses which have been 

claimed as CBI subject to Agency 

confidentiality regulations at 40 CFR 

part 2 and 40 CFR part 720, subpart E. 

Absent a final determination or other 

disposition of the confidentiality claim 

under 40 CFR part 2 procedures, EPA is 

required to keep this information 

confidential. EPA promulgated a 

procedure at 40 CFR 721.11 to deal with 

the situation where a specific significant 

new use is CBI. 

Under these procedures a 

manufacturer or processor may request 

EPA to identify the confidential 

significant new use under the rule. The 

manufacturer or processor must show 

that it has a bona fide intent to 

manufacture or process the chemical 

substance. If EPA concludes that the 

person has shown a bona fide intent to 

manufacture or process the chemical 

substance, EPA will identify the 

confidential significant new use to that 

person. Since most of the chemical 

identities of the chemical substances 

subject to these SNURs are also CBI, 

manufacturers and processors can 

combine the bona fide submission 

under the procedure in 40 CFR 721.11 

into a single step. 

D. Applicability of General Provisions 

General provisions for SNURs appear 

in 40 CFR part 721, subpart A. These 

provisions describe persons subject to 

SNURs, recordkeeping requirements, 

exemptions to reporting requirements, 

and applicability of the rule to uses 

occurring before the effective date of the 

rule. Pursuant to 40 CFR 721.1(c), 

persons subject to SNURs must comply 

with the same requirements and EPA 

regulatory procedures as submitters of 

PMNs under TSCA section 5(a)(1)(A). In 

particular, these requirements include 

the information submission 

requirements of TSCA sections 5(b) and 

5(d)(1), the exemptions authorized by 

TSCA sections 5(h)(1), 5(h)(2), 5(h)(3), 

and 5(h)(5) and the regulations at 40 

CFR part 720. In addition, provisions 

relating to user fees appear at 40 CFR 

part 700. 

Once EPA receives a SNUN, EPA 

must either determine that the 

significant new use is not likely to 

present an unreasonable risk of injury 

under the conditions of use for the 

chemical substance or take such 

regulatory action as is associated with 

an alternative determination under 

TSCA section 5 before the manufacture 

(including import) or processing for the 

significant new use can commence. If 

EPA determines that the significant new 

use of the chemical substance is not 

likely to present an unreasonable risk, 

EPA is required under TSCA section 

5(g) to make public, and submit for 

publication in the Federal Register, a 

statement of EPA’s findings. 

As discussed in Unit I.C.2., persons 

who export or intend to export a 

chemical substance identified in a 

proposed or final SNUR are subject to 

the export notification provisions of 

TSCA section 12(b), and persons who 

import a chemical substance identified 

in a final SNUR are subject to the TSCA 

section 13 import certification 

requirements. See also https://

www.epa.gov/tsca-import-exportrequirements. 

E. Applicability of the Proposed SNURs 

to Uses Occurring Before the Effective 

Date of the Final Rule 

To establish a significant new use, 

EPA must determine that the use is not 

ongoing. The chemical substances 

subject to this proposed rule have 

undergone premanufacture review. In 

cases where EPA has not received a 

notice of commencement (NOC) and the 

chemical substance has not been added 

to the TSCA Inventory, no person may 

commence such activities without first 

submitting a PMN. Therefore, for 

chemical substances for which an NOC 

has not been submitted, EPA concludes 

that the designated significant new uses 

are not ongoing. The identities of many 

of the chemical substances subject to 

this proposed rule have been claimed as 

confidential per 40 CFR 720.85 and the 

PMN submitter did not intend to engage 

in the other circumstances of use that 

are designated as significant new uses 

for the chemical substances subject to 

this proposed rule. Based on this, the 

Agency believes that it is highly 

unlikely that any of the significant new 

uses identified in Unit III. are ongoing. 

When the chemical substances 

identified in Unit III. are added to the 

TSCA Inventory, EPA recognizes that, 

before the rule is effective, other persons 

might engage in a use that has been 

identified as a significant new use. 


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Persons who begin manufacture or 

processing of the chemical substances 

for a significant new use identified on 

or after the designated cutoff date 

specified in Unit III.A. would have to 

cease any such activity upon the 

effective date of the final rule. To 

resume their activities, these persons 

would have to first comply with all 

applicable SNUR notification 

requirements and EPA would have to 

take action under TSCA section 5 

allowing manufacture or processing to 

proceed. 

F. Important Information About SNUN 

Submissions 

1. SNUN Submissions 

SNUNs must be submitted on EPA 

Form No. 7710–25, generated using ePMN software, and submitted to the 

Agency in accordance with the 

procedures set forth in 40 CFR 720.40 

and 721.25. E–PMN software is 

available electronically at https://

www.epa.gov/reviewing-new-chemicalsunder-toxic-substances-control-act-tsca. 

2. Development and Submission of 

Information 

EPA recognizes that TSCA section 5 

does not require development of any 

particular new information (e.g., 

generating test data) before submission 

of a SNUN. There is an exception: If a 

person is required to submit information 

for a chemical substance pursuant to a 

rule, order or consent agreement under 

TSCA section 4, then TSCA section 

5(b)(1)(A) requires such information to 

be submitted to EPA at the time of 

submission of the SNUN. 

In the absence of a rule, TSCA order, 

or consent agreement under TSCA 

section 4 covering the chemical 

substance, persons are required only to 

submit information in their possession 

or control and to describe any other 

information known to or reasonably 

ascertainable by them (see 40 CFR 

720.50). However, upon review of PMNs 

and SNUNs, the Agency has the 

authority to require appropriate testing. 

To assist with EPA’s analysis of the 

SNUN, submitters are encouraged, but 

not required, to provide the potentially 

useful information identified for the 

chemical substance in Unit III.C. 

EPA strongly encourages persons, 

before performing any testing, to consult 

with the Agency pertaining to protocol 

selection. Furthermore, pursuant to 

TSCA section 4(h), which pertains to 

reduction of testing in vertebrate 

animals, EPA encourages consultation 

with the Agency on the use of 

alternative test methods and strategies 

(also called New Approach 

Methodologies, or NAMs), if available, 

to generate the recommended test data. 

EPA encourages dialog with Agency 

representatives to help determine how 

best the submitter can meet both the 

data needs and the objective of TSCA 

section 4(h). For more information on 

alternative test methods and strategies 

to reduce vertebrate animal testing, visit 

https://www.epa.gov/assessing-andmanaging-chemicals-under-tsca/ 

alternative-test-methods-and-strategiesreduce. 

The potentially useful information 

described in Unit III. may not be the 

only means of providing information to 

evaluate the chemical substance 

associated with the significant new 

uses. However, submitting a SNUN 

without any test data may increase the 

likelihood that EPA will take action 

under TSCA sections 5(e) or 5(f). EPA 

recommends that potential SNUN 

submitters contact EPA early enough so 

that they will be able to conduct the 

appropriate tests. 

SNUN submitters should be aware 

that EPA will be better able to evaluate 

SNUNs which provide detailed 

information on the following: 

• Human exposure and 

environmental release that may result 

from the significant new use of the 

chemical substances. 

III. Chemical Substances Subject to 

These Proposed SNURs 

A. What is the designated cutoff date for 

ongoing uses? 

EPA designates September 27, 2024, 

as the cutoff date for determining 

whether the new use is ongoing. This 

designation is explained in more detail 

in Unit II.E. 

B. What information is provided for 

each chemical substance? 

For each chemical substance 

identified in Unit III.C., EPA provides 

the following information: 

• PMN number (the proposed CFR 

citation assigned in the regulatory text 

section of this document). 

• Chemical name (generic name if the 

specific name is claimed as CBI). 

• Chemical Abstracts Service Registry 

Number (CASRN) (if assigned for nonconfidential chemical identities). 

• Basis for the SNUR. 

• Potentially useful information. 

The regulatory text section of this 

document specifies the activities 

designated as significant new uses. 

Certain new uses, including production 

volume limits and other uses designated 

in the proposed rules, may be claimed 

as CBI. 

These chemical substances have 

undergone premanufacture review. In 

addition to those conditions of use 

intended by the submitter, EPA has 

identified certain other circumstances of 

use. EPA has preliminarily determined 

that these chemicals under their 

conditions of use are not likely to 

present an unreasonable risk. However, 

EPA has not assessed risks associated 

with the other circumstances of use for 

these chemicals. EPA is proposing to 

designate these other circumstances of 

use as significant new uses. As a result, 

those significant new uses cannot occur 

without first going through a separate, 

subsequent EPA review and 

determination process associated with a 

SNUN. 

C. Which chemical substances are 

subject to this proposed rule? 

The substances subject to the 

proposed rules in this document are as 

follows: 

PMN Number (Proposed CFR Citation): 

P–15–633 (40 CFR 721.11925) 

Chemical Name: 1(2H)- 

Naphthalenone,4-ethyloctahydro-8- 

methyl. 

CAS Number: 870515–09–6. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as part of a 

fragrance formula (dispersive use). 

Based on estimated physical/chemical 

properties of the PMN substance, 

submitted test data on the new chemical 

substance, and comparison to analogous 

neutral organic substances, EPA has 

identified concerns for skin irritation, 

dermal sensitization, systemic effects 

(liver, spleen, and bone marrow effects), 

and aquatic toxicity if the new chemical 

substance is not used following the 

limitation noted. The conditions of use 

of the PMN substance as described in 

the PMN includes the following 

protective measure: 

• No release of the PMN substance 

resulting in surface water 

concentrations that exceed 43 ppb. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the environmental effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of aquatic 

toxicity testing may be potentially 

useful to characterize the environmental 

effects of the PMN substance. 


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PMN Number (Proposed CFR Citation): 

P–16–326 (40 CFR 721.11926) 

Chemical Name: Propanoic acid, 2,2- 

dimethyl-,-1-methyl-2-(1-methylethoxy)- 

2-oxoethyl ester. 

CAS Number: 1821051–37–9. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as part of a 

fragrance formula. Based on estimated 

physical/chemical properties of the 

PMN substance, submitted test data on 

the new chemical substance, and 

comparison to analogous esters, EPA 

has identified concerns for systemic 

effects (liver effects) and aquatic toxicity 

if the chemical substance is not used 

following the limitations noted. The 

conditions of use of the PMN substance 

as described in the PMN includes the 

following protective measure: 

• No processing of the PMN 

substance above 1% in formulation for 

consumer products. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the health effects of the PMN substance 

if a manufacturer or processor is 

considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of systemic 

effects testing may be potentially useful 

to characterize the health effects of the 

PMN substance. 

PMN Number (Proposed CFR Citation): 

P–17–195 (40 CFR 721.11927) 

Chemical Name: 1,3-Propanediol,2- 

methylene-, substituted (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be for 

manufacturing a modified ethylene 

vinyl alcohol copolymer. Based on the 

estimated physical/chemical properties 

of the PMN substance, comparison to 

analogous chemical substances, 

submitted data on the PMN substance, 

and comparison to analogous esters and 

vinyl esters, EPA has identified 

concerns for acute oral toxicity, 

systemic effects, developmental effects, 

and aquatic toxicity if the chemical 

substance is not used following the 

limitations noted. The condition of use 

of the PMN substance as described in 

the PMN includes the following 

protective measure: 

• No use of the PMN substance other 

than as a chemical intermediate. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the environmental effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of aquatic 

toxicity testing may be potentially 

useful to characterize the environmental 

effects of the PMN substance. 

PMN Number (Proposed CFR Citation): 

P–17–389 (40 CFR 721.11928) 

Chemical Name: Alkyl oil, polymer 

with 1,4-cyclohexanedimethanol, 

dehydrated alkyl oil, hydrogenated 

rosin, phthalic anhydride and 

trimethylolpropane (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as a polymer 

precursor. Based on estimated physical/ 

chemical properties of the PMN 

substance, comparison to structurally 

analogous chemical substances, and 

comparison to analogous esters, EPA 

has identified concerns for bladder 

effects, developmental toxicity, and 

aquatic toxicity if the chemical 

substance is not used following the 

limitations noted. The conditions of use 

of the PMN substance as described in 

the PMN include the following 

protective measures: 

• No manufacturing, processing, or 

use of the PMN substance in a manner 

that results in inhalation exposure; and 

• No release of the PMN substance 

resulting in surface water 

concentrations that exceed 39 ppb. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health and environmental 

effects of the PMN substance if a 

manufacturer or processor is 

considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of chronic 

ecotoxicity, skin absorption, metabolism 

or pharmacokinetics, specific target 

organ toxicity, developmental toxicity, 

and chronic toxicity/carcinogenicity 

testing may be potentially useful to 

characterize the health and 

environmental effects of the PMN 

substance. 

PMN Number (Proposed CFR Citation): 

P–18–98 (40 CFR 721.11929) 

Chemical Name: Polyphosphoric 

acids, polymers with 

(alkoxyalkoxy)alkanol and substituted 

heteromonocycle (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the use of the PMN substance will be as 

a dispersing additive for pigments. 

Based on estimated physical/chemical 

properties of the PMN substance, 

comparison to structurally analogous 

chemical substances, and comparison to 

analogous anionic surfactants, EPA has 

identified concerns for irritation of the 

skin, eyes, and respiratory tract, 

reproductive and developmental effects, 

lung effects, and aquatic toxicity if the 

chemical substance is not used 

following the limitations noted. The 

conditions of use of the PMN substance 

as described in the PMN include the 

following protective measures: 

• No processing of the PMN 

substance to greater than 5% by weight 

in the final formulated product for any 

use; and 

• No release of the PMN substance 

resulting in surface water 

concentrations that exceed 16 ppb. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health and environmental 

effects of the PMN substance if a 

manufacturer or processor is 

considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of aquatic 

toxicity, skin irritation, eye irritation, 

reproductive toxicity, and pulmonary 

effects testing may be potentially useful 

to characterize the health and 

environmental effects of the PMN 

substance. 

PMN Number (Proposed CFR Citation): 

P–18–150 (40 CFR 721.11930) 

Chemical Name: Tertiary amine, 

compounds with amino sulfonic acid 

blocked aliphatic isocyanate 

homopolymer (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as a component 

of an industrial coating. Based on 

estimated physical/chemical properties 

of the PMN substance, submitted test 

data on the new chemical substance, 

comparison to structurally analogous 

chemical substances, and comparison to 

analogous diisocyanates, EPA has 

identified concerns for systemic toxicity 

if the chemical substance is not used 

following the limitations noted. The 

conditions of use of the PMN substance 


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as described in the PMN include the 

following protective measures: 

• No domestic manufacture (i.e., 

import only); 

• Use of the PMN substance only for 

the confidential use described in the 

PMN; and 

• Use of a National Institute for 

Occupational Safety and Health 

(NIOSH)-certified respirator with an 

Assigned Protection Factor (APF) of at 

least 10 where there is a potential for 

inhalation exposure. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of 

pulmonary effects and specific target 

organ toxicity testing may be potentially 

useful to characterize the health effects 

of the PMN substance. 

PMN Number (Proposed CFR Citation): 

P–18–187 (40 CFR 721.11931) 

Chemical Name: Carboxylic acidpolyamine condensate (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as an emulsifier. 

Based on estimated physical/chemical 

properties of the PMN substance, 

comparison to structurally analogous 

chemical substances, and comparison to 

analogous aliphatic amines, EPA has 

identified concerns for skin and 

respiratory sensitization, developmental 

toxicity, lung effects, skin, eye, and lung 

irritation, and aquatic toxicity if the 

chemical substance is not used 

following the limitations noted. The 

conditions of use of the PMN substance 

as described in the PMN include the 

following protective measures: 

• No manufacturing, processing, or 

use of the PMN substance in a manner 

that results in inhalation exposure; and 

• No release of the PMN substance 

resulting in surface water 

concentrations that exceed 1 ppb. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health and environmental 

effects of the PMN substance if a 

manufacturer or processor is 

considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of 

absorption, specific target organ toxicity 

or pulmonary effects, reproductive 

(developmental effects) toxicity, skin 

sensitization, and aquatic toxicity 

testing may be potentially useful to 

characterize the health and 

environmental effects of the PMN 

substance. 

PMN Number (Proposed CFR Citation): 

P–18–211 (40 CFR 721.11932) 

Chemical Name: Alkaneamine, 

(aminoalkyl)-, polymer with aziridine 

and 1,6-diisocyanatohexane, 

polyethylene glycol alkyl ether- and 

polyethylene-polypropylene glycol 

aminoalkyl alkyl ether- and alkenyl 

benzenated polyethylene glycol Ph ether 

(generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the use of the PMN substance will be as 

a wetting and dispersing agent for 

pigment formulations, paints, and 

coatings. Based on estimated physical/ 

chemical properties of the PMN 

substance, comparison to structurally 

analogous chemical substances, and 

comparison to analogous polycationic 

polymers, EPA has identified concerns 

for lung effects, irritation, and aquatic 

toxicity if the chemical substance is not 

used following the limitations noted. 

The conditions of use of the PMN 

substance as described in the PMN 

include the following protective 

measures: 

• No use of the PMN substance in 

spray applications; 

• No consumer use of the PMN 

substance; and 

• No release of the PMN substance 

resulting in surface water 

concentrations that exceed 16 ppb. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health and environmental 

effects of the PMN substance if a 

manufacturer or processor is 

considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of 

absorption, pulmonary effects, specific 

target organ toxicity, and aquatic 

toxicity testing may be potentially 

useful to characterize the health and 

environmental effects of the PMN 

substance. 

PMN Numbers (Proposed CFR 

Citations): P–18–267 (40 CFR 

721.11933), P–18–268 (40 CFR 

721.11934) and P–18–269 (40 CFR 

721.11935) 

Chemical Names: Branched alkanoic 

acid, epoxy ester, reaction products 

with monocyclic dialkylamine and 

polycyclic alcohol epoxy polymer 

(generic) (P–18–267), Polycyclic alkane, 

polymer with monocyclic amine, 

polycyclic epoxide ether, reaction 

products with dialkylamine alkyl amine 

(generic) (P–18–268), and Polycyclic 

substituted alkane, polymer with 

epoxide, reaction products with 

cyclicalkylamine and dialkylamine 

substituted alkyl amine (generic) (P–18– 

269). 

CAS Numbers: Not available. 

Basis for action: The PMNs state that 

the generic (non-confidential) use of the 

PMN substances will be as curing 

agents. Based on estimated physical/ 

chemical properties of the PMN 

substances and comparison to 

structurally analogous chemical 

substances, EPA has identified concerns 

for lung effects, irritation, and systemic 

toxicity if the chemical substances are 

not used following the limitations 

noted. The conditions of use of the PMN 

substances as described in the PMNs 

includes the following protective 

measure: 

• No use of the PMN substances in a 

spray application method where more 

than 1% of particles are less than 10 

microns in diameter. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health effects of the PMN 

substances if a manufacturer or 

processor is considering submitting a 

SNUN for a significant new use that will 

be designated by this SNUR. EPA has 

determined that the results of 

pulmonary effects, specific target organ 

toxicity, skin irritation/corrosion, eye 

damage, and particle size testing may be 

potentially useful to characterize the 

health effects of the PMN substances. 

PMN Number (Proposed CFR Citation): 

P–18–376 (40 CFR 721.11936) 

Chemical Name: Thiosulfuric acid, 

aminoalkyl ester (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the use of the PMN substance will be to 

improve physical properties in rubber 

products. Based on estimated physical/ 

chemical properties of the PMN 

substance and submitted test data on the 


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new chemical substance, EPA has 

identified concerns for irritation to the 

eye and skin, skin sensitization, 

systemic toxicity, and reproductive/ 

developmental effects if the chemical 

substance is not used following the 

limitations noted. The conditions of use 

of the PMN substance as described in 

the PMN include the following 

protective measures: 

• No domestic manufacture (i.e., 

import only); and 

• No use of the PMN substance other 

than for incorporating into rubber 

products. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that human exposure 

information would be useful to 

characterize the potential effects of the 

PMN substance. 

PMN Number (Proposed CFR Citation): 

P–18–380 (40 CFR 721.11937) 

Chemical Name: Butanoic acid ethyl 

amine (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be for automotive 

brake parts. Based on estimated 

physical/chemical properties of the 

PMN substance, comparison to 

structurally analogous chemical 

substances, and comparison to 

analogous substances, EPA has 

identified concerns for surfactant effects 

on the lung, eye irritation, and aquatic 

toxicity if the chemical substance is not 

used following the limitations noted. 

The conditions of use of the PMN 

substance as described in the PMN 

include the following protective 

measures: 

• No domestic manufacture (i.e., 

import only); 

• No import of the PMN substance 

other than in the confidential form 

described in the PMN; and 

• No processing of the PMN 

substance in end use formulations to 

greater than the confidential 

concentration percentage identified in 

the PMN. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health and environmental 

effects of the PMN substance if a 

manufacturer or processor is 

considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of 

pulmonary effects, eye irritation, and 

aquatic toxicity testing may be 

potentially useful to characterize the 

health and environmental effects of the 

PMN substance. 

PMN Number (Proposed CFR Citation): 

P–18–389 (40 CFR 721.11938) 

Chemical Name: Alkenoic acid, alkylsubstituted, epoxy ester, polymer with 

alkyl alkenoate, alkene, and polylactide 

(generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as a component 

in package coatings. Based on estimated 

physical/chemical properties of the 

PMN substance and comparison to 

structurally analogous chemical 

substances, EPA has identified concerns 

for lung effects if the chemical 

substance is not used following the 

limitations noted. The conditions of use 

of the PMN substance as described in 

the PMN includes the following 

protective measure: 

• No manufacturing, processing, or 

use of the PMN substance in a manner 

that results in inhalation exposure. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of specific 

target organ toxicity testing may be 

potentially useful to characterize the 

health effects of the PMN substance. 

PMN Number (Proposed CFR Citation): 

P–18–396 (40 CFR 721.11939) 

Chemical Name: Alkenoic acid, alkyl, 

polymer with carbomonocyle alkyl 

propenoate and substituted alkyl 

alkenoate, ester with substituted alkyl 

alkanoate, tertbutyl substituted 

peroxoate-initiated (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as paint. Based 

on estimated physical/chemical 

properties of the PMN substance and 

comparison to structurally analogous 

chemical substances, EPA has identified 

concerns for developmental effects and 

eye, skin, and respiratory tract irritation 

if the chemical substance is not used 

following the limitations noted. The 

conditions of use of the PMN substance 

as described in the PMN include the 

following protective measures: 

• No consumer use of the PMN 

substance; and 

• Use of the PMN substance only for 

the confidential use described in the 

PMN. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of 

reproductive toxicity, skin irritation, 

and eye irritation testing may be 

potentially useful to characterize the 

health effects of the PMN substance. 

PMN Number (Proposed CFR Citation): 

P–19–134 (40 CFR 721.11940) 

Chemical Name: 5-isocyanato-1- 

(isocyanatomethyl)-1,3,3- 

trimethylcyclohexane, poly[oxy(methyl1,2-ethanediyl), .alpha.-hydro-.omega.- 

hydroxy-, polymer with 1,6- 

diisocyanatohexane, polymer with 

poly(oxy-1,4-butanediyl), .alpha.-hydro- 

.omega.-hydroxy-, cyclic amine—ketone 

adduct, reduced, and 1,3-propanediol, 

2-ethyl-2-(hydroxymethyl)- (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the use of the PMN substance will be as 

a binder for moisture cure coatings. 

Based on the estimated physical/ 

chemical properties of the PMN 

substance and comparison to analogous 

chemical substances, EPA has identified 

concerns for respiratory sensitization, 

skin sensitization, lung effects, and 

systemic effects if the chemical 

substance is not used following the 

limitations noted. The conditions of use 

of the PMN substance as described in 

the PMN includes the following 

protective measure: 

• No consumer use of the PMN 

substance. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 


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designated by this SNUR. EPA has 

determined that the results of skin 

sensitization and pulmonary effects 

testing may be potentially useful to 

characterize the health effects of the 

PMN substance. 

PMN Number (Proposed CFR Citation): 

P–19–161 (40 CFR 721.11941) 

Chemical Name: Alkanol amine salt 

mixture (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the use of the PMN substance will be as 

an organic amine salt mixture used as a 

foaming agent in the production of 

urethanes. Based on the estimated 

physical/chemical properties of the 

PMN substance, data on chemicals 

identified in the chemical structure, and 

comparison to analogous chemical 

substances, EPA has identified concerns 

for irritation to skin, eyes, and 

respiratory tract, and systemic effects if 

the chemical substance is not used 

following the limitations noted. The 

conditions of use of the PMN substance 

as described in the PMN includes the 

following protective measure: 

• No consumer use of the PMN 

substance. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of skin 

irritation, eye irritation, and specific 

target organ toxicity testing may be 

potentially useful to characterize the 

health effects of the PMN substance. 

PMN Number (Proposed CFR Citation): 

P–19–170 (40 CFR 721.11942) 

Chemical Name: Heteroatomsubstituted alkyl triethoxysilane, 

reaction products with methylated 

formaldehyde-melamine polymer 

(generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the use of the PMN substance will be as 

a coupling agent in elastomer-based 

formulations that will be used in 

molding operations to manufacture 

different types of rubber articles 

including but not limited to rubber tires. 

Based on estimated physical/chemical 

properties of the PMN substance, 

comparison to analogous alkoxysilanes, 

and comparison to structurally 

analogous chemical substances, EPA has 

identified concerns for irritation to all 

exposed tissues, lung effects, systemic 

effects, carcinogenicity, and aquatic 

toxicity if the chemical substance is not 

used following the limitations noted. 

The conditions of use of the PMN 

substance as described in the PMN 

include the following protective 

measures: 

• No release of the PMN substance, or 

any waste stream containing the PMN 

substance, into water; 

• No manufacturing, processing, or 

use of the PMN substance in a manner 

that results in inhalation exposure; and 

• Use of the PMN substance only as 

a coupling agent in elastomer-based 

formulations that will be used in 

molding operations to manufacture 

different types of rubber articles 

including but not limited to rubber tires. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health and environmental 

effects of the PMN substance if a 

manufacturer or processor is 

considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of skin 

irritation, eye irritation, specific target 

organ toxicity, pulmonary effects, 

carcinogenicity, and aquatic toxicity 

testing may be potentially useful to 

characterize the health and 

environmental effects of the PMN 

substance. 

PMN Number (Proposed CFR Citation): 

P–19–189 (40 CFR 721.11943) 

Chemical Name: Fatty acids, 

polymers with alkanediol and 1,1′- 

methylenebis[4-isocyanatobenzene] 

(generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the use of the PMN substance will be as 

a reactive polymer for use in adhesives 

and sealants. Based on estimated 

physical/chemical properties of the 

PMN substance, submitted test data on 

the new chemical substance, and 

comparison to structurally analogous 

chemical substances, EPA has identified 

concerns for skin and respiratory 

sensitization if the chemical substance 

is not used following the limitations 

noted. The conditions of use of the PMN 

substance as described in the PMN 

include the following protective 

measures: 

• Use of the PMN substance only as 

a reactive polymer for use in adhesives 

and sealants; and 

• No manufacturing, processing, or 

use of the PMN substance in a manner 

that results in inhalation exposure. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that human exposure 

information may be potentially useful to 

characterize the effects of the PMN 

substance. 

PMN Number (Proposed CFR Citation): 

P–20–8 (40 CFR 721.11944) 

Chemical Name: 7- 

Heteropolycyclicsulfonic acid, 2-[4-[2- 

[1-[[(2-methoxy-5-methyl-4- 

sulfophenyl)amino]carbonyl]-2- 

oxopropyl]diazenyl]phenyl]-6-methyl-, 

compd. with (alkylamino)alkanol and 

(hydroxyalkyl)amine (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the use of the PMN substance will be as 

a dye for use with paper, paper 

products, and nonwoven products 

produced from paper. Based on 

estimated physical/chemical properties 

of the PMN substance, submitted test 

data on the new chemical substance, 

comparison with analogous acid dyes, 

amphoteric dyes, and anilines, and 

comparison to structurally analogous 

chemical substances, EPA has identified 

concerns for systemic and 

developmental effects and aquatic 

toxicity if the chemical substance is not 

used following the limitations noted. 

The conditions of use of the PMN 

substance as described in the PMN 

include the following protective 

measures: 

• No use other than as a dye for use 

with paper, paper products, and 

nonwoven products produced from 

paper. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health and environmental 

effects of the PMN substance if a 

manufacturer or processor is 

considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of specific 

target organ toxicity and aquatic toxicity 

testing may be potentially useful to 

characterize the health and 


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environmental effects of the PMN 

substance. 

PMN Number (Proposed CFR Citation): 

P–20–12 (40 CFR 721.11945) 

Chemical Name: Polyol, polymer with 

alkyl diisocyanate, alkyl substituted 

heterocycle blocked (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as an ink 

additive. Based on estimated physical/ 

chemical properties of the PMN 

substance, submitted test data on the 

new chemical substance, and 

comparison to structurally analogous 

chemical substances, EPA has identified 

concerns for systemic effects (spleen, 

liver, and blood), and aquatic toxicity if 

the new chemical substance is not used 

following the limitation noted. The 

conditions of use of the PMN substance 

as described in the PMN include the 

following protective measure: 

• No release of the PMN substance 

resulting in surface water 

concentrations that exceed 5 ppb. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the environmental effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of aquatic 

toxicity testing may be potentially 

useful to characterize the environmental 

effects of the PMN substance. 

PMN Number (Proposed CFR Citation): 

P–20–22 (40 CFR 721.11946) 

Chemical Name: 

Polyalkoxycarbopolycycle hydroxy 

(generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as a fuel additive 

for combustion improver. Based on 

estimated physical/chemical properties 

of the PMN substance and comparison 

to structurally analogous chemical 

substances, EPA has identified concerns 

for systemic effects, lung effects 

(surfactancy), and aquatic toxicity if the 

chemical substance is not used 

following the limitations noted. The 

conditions of use of the PMN substance 

as described in the PMN include the 

following protective measures: 

• No manufacturing, processing, or 

use of the PMN substance in a manner 

that results in inhalation exposure; and 

• No release of the PMN substance 

resulting in surface water 

concentrations that exceed 44 ppb. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health and environmental 

effects of the PMN substance if a 

manufacturer or processor is 

considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of specific 

target organ toxicity, pulmonary effects, 

neurotoxicity, and aquatic toxicity 

testing may be potentially useful to 

characterize the health and 

environmental effects of the PMN 

substance. 

PMN Numbers (Proposed CFR 

Citations): P–20–27 (40 CFR 721.11947) 

and P–20–28 (40 CFR 721.11948) 

Chemical Names: Glycols, .alpha., 

.omega.-, C2-6, polymers with adipic 

acid, dodecanedioic acid, hydracrylic 

acid polyester, isophthalic acid, 

isophthalic acid, 1,1′-methylenebis[4- 

isocyanatobenzene], neopentyl glycol 

and terephthalic acid (generic) (P–20– 

27) and Glycols, .alpha.,.omega.-, C2-6, 

polymers with adipic acid, aromatic 

polyester, dodecanedioic acid, 

hydracrylic acid polyester, isophthalic 

acid, 1,1′-methylenebis[4- 

isocyanatobenzene], neopentyl glycol 

and terephthalic acid (generic) (P–20– 

28). 

CAS Numbers: Not available. 

Basis for action: The PMNs state that 

the generic (non-confidential) use of the 

PMN substances will be as industrial 

adhesives. Based on the estimated 

physical/chemical properties of the 

PMN substances and comparison to 

structurally analogous chemical 

substances, EPA has identified concerns 

for irritation to the skin, eyes, and 

respiratory tract, dermal and respiratory 

sensitization, lung effects, and 

carcinogenicity if the new chemical 

substances are not used following the 

limitations noted. The conditions of use 

of the PMN substances as described in 

the PMNs include the following 

protective measures: 

• No release of the PMN substances 

into the waters of the United States; 

• No consumer use of the PMN 

substances; and 

• No manufacturing, processing, or 

use of the PMN substances in a manner 

that results in inhalation exposure. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health effects of the PMN 

substances if a manufacturer or 

processor is considering submitting a 

SNUN for a significant new use that will 

be designated by this SNUR. EPA has 

determined that the results of skin 

irritation, eye damage, skin 

sensitization, specific target organ 

toxicity, pulmonary effects, genetic 

toxicity, and carcinogenicity testing may 

be potentially useful to characterize the 

health effects of the PMN substances. 

PMN Number (Proposed CFR Citation): 

P–20–50 (40 CFR 721.11949) 

Chemical Name: Benzenepentanol, 

alpha, gamma-dimethyl. 

CAS Number: 72681–01–7. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as an additive in 

consumer products. Based on estimated 

physical/chemical properties of the 

PMN substance, submitted test data on 

the new chemical substance, and 

comparison to analogous neutral organic 

substances, EPA has identified concerns 

for systemic toxicity and aquatic 

toxicity if the new chemical substance 

is not used following the limitation 

noted. The conditions of use of the PMN 

substance as described in the PMN 

include the following protective 

measure: 

• No release of the PMN substance 

resulting in surface water 

concentrations that exceed 71 ppb. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the environmental effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of aquatic 

toxicity testing may be potentially 

useful to characterize the environmental 

effects of the PMN substance. 

PMN Number (Proposed CFR Citation): 

P–20–54 (40 CFR 721.11950) 

Chemical Name: Nitrile hydratase. 

CAS Number: 82391–37–5. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as a catalyst 

used in a closed process. Based on 

estimated physical/chemical properties 

of the PMN substance, submitted test 

data on the new chemical substance, 

and comparison to structurally 

analogous chemical substances, EPA has 


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identified concerns for respiratory 

sensitization and/or allergic reactions 

and irritation to the eyes and respiratory 

tract if the chemical substance is not 

used following the limitations noted. 

The conditions of use of the PMN 

substance as described in the PMN 

includes the following protective 

measure: 

• No manufacturing, processing, or 

use of the PMN substance in a manner 

that results in inhalation exposure. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of eye 

irritation and sensitization testing may 

be potentially useful to characterize the 

health effects of the PMN substance. 

PMN Number (Proposed CFR Citation): 

P–20–56 (40 CFR 721.11951) 

Chemical Name: Polyphosphoric 

acids, 2-[(alkyl-1-oxo-alkene-1- 

yl)oxy]alkyl esters, polymers with 

acrylic acid, alkyl acrylate, alkyl 

methacrylate, hydroxyalkyl 

methacrylate and carbomonocycle, 2,2′- 

(1,2-diazenediyl)bis[2,4- 

dialkylalkanenitrogensubstituted]- 

initiated (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as a pigment 

dispersant. Based on estimated 

physical/chemical properties of the 

PMN substance, comparison to 

analogous chemical substances, and 

comparison to analogous polyanionic 

polymers and monomers) and 

phosphate esters, EPA has identified 

concerns for developmental toxicity, 

delayed neurotoxicity, mutagenicity, 

and aquatic toxicity if the new chemical 

substance is not used following the 

limitation noted. The conditions of use 

of the PMN substance as described in 

the PMN include the following 

protective measure: 

• No release of the PMN substance 

resulting in surface water 

concentrations that exceeds 1 ppb. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health and environmental 

effects of the PMN substance if a 

manufacturer or processor is 

considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of 

developmental toxicity, specific target 

organ toxicity, genetic toxicity, 

neurotoxicity, and aquatic toxicity 

testing may be potentially useful to 

characterize the health and 

environmental effects of the PMN 

substance. 

PMN Number (Proposed CFR Citation): 

P–20–57 (40 CFR 721.11952) 

Chemical Name: Arene, 

trimethoxysilyl-, hydrolyzed (generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as a silane 

coupling agent used in silicone 

formulations. Based on estimated 

physical/chemical properties of the 

PMN substance and comparison to 

structurally analogous chemical 

substances, EPA has identified concerns 

for lung toxicity, irritation to the skin, 

eyes, and respiratory tract, systemic and 

reproductive effects, and neurological 

and developmental effects if the 

chemical substance is not used 

following the limitations noted. The 

conditions of use of the PMN substance 

as described in the PMN include the 

following protective measure: 

• No manufacturing, processing, or 

use of the PMN substance in a manner 

that results in inhalation exposure. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health effects of the PMN 

substance if a manufacturer or processor 

is considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of specific 

target organ toxicity, neurotoxicity, 

pulmonary effects, reproductive/ 

developmental toxicity, developmental 

neurotoxicity, skin irritation and eye 

damage testing may be potentially 

useful to characterize the health effects 

of the PMN substance. 

PMN Number (Proposed CFR Citation): 

P–20–69 (40 CFR 721.11953) 

Chemical Name: 2-Propenoic acid, 2- 

methyl-, polymer with 2-hydroxyethyl 

2-methyl-2-propenoate phosphate and 

2-propenoic acid salt, peroxydisulfuric 

acid ([(HO)S(O)2]2O2) sodium salt (1:2)- 

and sodium (disulfite) (2:1)-initiated 

(generic). 

CAS Number: Not available. 

Basis for action: The PMN states that 

the generic (non-confidential) use of the 

PMN substance will be as a surfaceactive chemical. Based on the estimated 

physical/chemical properties of the 

PMN substance, submitted test data on 

the new chemical substance, 

comparison to analogous polyanionic 

polymers, and comparison to analogous 

chemical substances, EPA has identified 

concerns for developmental and 

systemic effects (i.e., blood toxicity) and 

aquatic toxicity if the chemical 

substance is not used following the 

limitations noted. The conditions of use 

of the PMN substance as described in 

the PMN includes the following 

protective measure: 

• Use of the PMN substance only for 

the confidential use described in the 

PMN. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of this protective measure. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health and environmental 

effects of the PMN substance if a 

manufacturer or processor is 

considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of 

reproductive toxicity (developmental 

effects), specific target organ, and 

aquatic toxicity testing may be 

potentially useful to characterize the 

health and environmental effects of the 

PMN substance. 

PMN Number (Proposed CFR Citation): 

P–20–74 (40 CFR 721.11954) 

Chemical Name: Oxirane, 2-methyl-, 

polymer with oxirane, monoundecyl 

ether, branched and linear. 

CAS Number: 2222805–23–2. 

Basis for action: The PMN states that 

the use of the PMN substance will be as 

a surfactant for use in the formulation 

of pesticide products. Based on 

estimated physical/chemical properties 

of the PMN substance, comparison to 

analogous nonionic surfactants, and 

comparison to structurally analogous 

chemical substances, EPA has identified 

concerns for irritation to the skin, eyes, 

and respiratory tract, systemic effects, 

developmental toxicity, and aquatic 

toxicity if the chemical substance is not 

used following the limitations noted. 

The conditions of use of the PMN 

substance as described in the PMN 

include the following protective 

measures: 

• No manufacturing, processing, or 

use of the PMN substance in a manner 

that results in inhalation exposure; and 


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• Use of the PMN substance only as 

a surfactant for use in the formulation 

of pesticide products. 

The proposed SNUR would designate 

as a ‘‘significant new use’’ the absence 

of these protective measures. 

Potentially Useful Information: EPA 

has determined that certain information 

may be potentially useful to characterize 

the human health and environmental 

effects of the PMN substance if a 

manufacturer or processor is 

considering submitting a SNUN for a 

significant new use that will be 

designated by this SNUR. EPA has 

determined that the results of skin 

irritation, eye irritation/corrosion, 

reproductive toxicity (developmental 

effects), neurotoxicity, specific target 

organ toxicity, and aquatic toxicity 

testing may be potentially useful to 

characterize the health and 

environmental effects of the PMN 

substance. 

IV. Statutory and Executive Order 

Reviews 

Additional information about these 

statutes and Executive orders can be 

found at https://www.epa.gov/lawsregulations-and-executive-orders. 

A. Executive Order 12866: Regulatory 

Planning and Review and Executive 

Order 14094: Modernizing Regulatory 

Review 

This action proposes to establish 

SNURs for new chemical substances 

that were the subject of PMNs. The 

Office of Management and Budget 

(OMB) has exempted these types of 

actions from review under Executive 

Order 12866 (58 FR 51735, October 4, 

1993), as amended by Executive Order 

14094 (88 FR 21879, April 11, 2023). 

B. Paperwork Reduction Act (PRA) 

According to the PRA (44 U.S.C. 3501 

et seq.), an agency may not conduct or 

sponsor, and a person is not required to 

respond to a collection of information 

that requires OMB approval under PRA, 

unless it has been approved by OMB 

and displays a currently valid OMB 

control number. The OMB control 

numbers for EPA’s regulations in title 40 

of the CFR, after appearing in the 

Federal Register, are listed in 40 CFR 

part 9, and included on the related 

collection instrument or form, if 

applicable. 

The information collection 

requirements related to SNURs have 

already been approved by OMB 

pursuant to PRA under OMB control 

number 2070–0038 (EPA ICR No. 1188). 

This action does not impose any burden 

requiring additional OMB approval. If 

an entity were to submit a SNUN to the 

Agency, the annual burden is estimated 

to average between 30 and 170 hours 

per submission. This burden estimate 

includes the time needed to review 

instructions, search existing data 

sources, gather and maintain the data 

needed, and complete, review, and 

submit the required SNUN. 

EPA always welcomes your feedback 

on the burden estimates. Send any 

comments about the accuracy of the 

burden estimate, and any suggested 

methods for improving the collection 

instruments or instruction or 

minimizing respondent burden, 

including through the use of automated 

collection techniques. 

C. Regulatory Flexibility Act (RFA) 

I certify that this action will not have 

a significant economic impact on a 

substantial number of small entities 

under the RFA (5 U.S.C. 601 et seq.). 

The requirement to submit a SNUN 

applies to any person (including small 

or large entities) who intends to engage 

in any activity described in the final 

rule as a ‘‘significant new use.’’ Because 

these uses are ‘‘new,’’ based on all 

information currently available to EPA, 

EPA has concluded that no small or 

large entities presently engage in such 

activities. 

A SNUR requires that any person who 

intends to engage in such activity in the 

future must first notify EPA by 

submitting a SNUN. Although some 

small entities may decide to pursue a 

significant new use in the future, EPA 

cannot presently determine how many, 

if any, there may be. However, EPA’s 

experience to date is that, in response to 

the promulgation of SNURs covering 

over 1,000 chemicals, the Agency 

receives only a small number of notices 

per year. For example, the number of 

SNUNs received was 16 in Federal fiscal 

year (FY) FY2018, five in FY2019, seven 

in FY2020, 13 in FY2021, 11 in FY2022, 

and 15 in FY2023, and only a fraction 

of these submissions were from small 

businesses. 

In addition, the Agency currently 

offers relief to qualifying small 

businesses by reducing the SNUN 

submission fee from $37,000 to $6,480. 

This lower fee reduces the total 

reporting and recordkeeping cost of 

submitting a SNUN to about $14,500 per 

SNUN submission for qualifying small 

firms. Therefore, the potential economic 

impacts of complying with these 

proposed SNURs are not expected to be 

significant or adversely impact a 

substantial number of small entities. In 

a SNUR that published in the Federal 

Register of June 2, 1997 (62 FR 29684) 

(FRL–5597–1), the Agency presented its 

general determination that SNURs are 

not expected to have a significant 

economic impact on a substantial 

number of small entities, which was 

provided to the Chief Counsel for 

Advocacy of the Small Business 

Administration. 

D. Unfunded Mandates Reform Act 

(UMRA) 

This action does not contain an 

unfunded mandate of $100 million or 

more (in 1995 dollars) in any one year 

as described in UMRA, 2 U.S.C. 1531– 

1538, and does not significantly or 

uniquely affect small governments. 

Based on EPA’s experience with 

proposing and finalizing SNURs, State, 

local, and Tribal governments have not 

been impacted by SNURs, and EPA does 

not have any reasons to believe that any 

State, local, or Tribal government will 

be impacted by these SNURs. In 

addition, the estimated costs of this 

action to the private sector do not 

exceed $183 million or more in any one 

year (the 1995 dollars are adjusted to 

2023 dollars for inflation using the GDP 

implicit price deflator). The estimated 

costs for this action are discussed in 

Unit I.D. 

E. Executive Order 13132: Federalism 

This action will not have federalism 

implications as specified in Executive 

Order 13132 (64 FR 43255, August 10, 

1999), because it is not expected to have 

a substantial direct effect on States, on 

the relationship between the national 

government and the States, or on the 

distribution of power and 

responsibilities among the various 

levels of government. Accordingly, the 

requirements of Executive Order 13132 

do not apply to this action. 

F. Executive Order 13175: Consultation 

and Coordination With Indian Tribal 

Governments 

This action will not have Tribal 

implications as specified in Executive 

Order 13175 (65 FR 67249, November 9, 

2000), because it is not expected to have 

substantial direct effects on Indian 

Tribes, significantly or uniquely affect 

the communities of Indian Tribal 

governments and does not involve or 

impose any requirements that affect 

Indian Tribes. Accordingly, the 

requirements of Executive Order 13175 

do not apply to this action. 

G. Executive Order 13045: Protection of 

Children From Environmental Health 

Risks and Safety Risks 

This action is not subject to Executive 

Order 13045 (62 FR 19885, April 23, 

1997), because it does not concern an 

environmental health or safety risk. 

Since this action does not concern a 


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human health risk, EPA’s 2021 Policy 

on Children’s Health also does not 

apply. Although the establishment of 

these SNURs do not address an existing 

children’s environmental health 

concern because the chemical uses 

involved are not ongoing uses, SNURs 

require that persons notify EPA at least 

90 days before commencing 

manufacture (defined by statute to 

include import) or processing of any of 

these chemical substances for an 

activity that is designated as a 

significant new use by this rulemaking. 

This notification allows EPA to assess 

the intended uses to identify potential 

risks and take appropriate actions before 

the activities commence. 

H. Executive Order 13211: Actions 

Concerning Regulations That 

Significantly Affect Energy Supply, 

Distribution, or Use 

This action is not a ‘‘significant 

energy action’’ as defined in Executive 

Order 13211 (66 FR 28355, May 22, 

2001), because it is not likely to have a 

significant adverse effect on the supply, 

distribution, or use of energy. 

I. National Technology Transfer and 

Advancement Act (NTTAA) 

This action does not involve any 

technical standards subject to NTTAA 

section 12(d) (15 U.S.C. 272 note). 

J. Executive Order 12898: Federal 

Actions To Address Environmental 

Justice in Minority Populations and 

Low-Income Populations and Executive 

Order 14096: Revitalizing Our Nation’s 

Commitment to Environmental Justice 

for All 

This action does not concern human 

health or environmental conditions and 

therefore cannot be evaluated with 

respect to the potential for 

disproportionate impacts on non-white 

and low-income populations in 

accordance with Executive Order 12898 

(59 FR 7629, February 16, 1994) and 

Executive Order 14096 (88 FR 25251, 

April 26, 2023). Although this action 

does not concern human health or 

environmental conditions, the 

premanufacture notifications required 

by these SNURs allows EPA to assess 

the intended uses to identify potential 

disproportionate risks and take 

appropriate actions before the activities 

commence. 

List of Subjects in 40 CFR Part 721 

Environmental protection, Chemicals, 

Hazardous substances, Reporting and 

recordkeeping requirements. 

Dated: September 23, 2024. 

Mary Elissa Reaves, 

Director, Office of Pollution Prevention and 

Toxics. 

Therefore, for the reasons stated in the 

preamble, EPA proposes to amend 40 

CFR chapter I as follows: 

PART 721—SIGNIFICANT NEW USES 

OF CHEMICAL SUBSTANCES 

■ 1. The authority citation for part 721 

continues to read as follows: 

Authority: 15 U.S.C. 2604, 2607, and 

2625(c). 

■ 2. Add §§ 721.11925 through 

721.11954 to subpart E to read as 

follows: 

Subpart E—Significant New Uses for 

Specific Chemical Substances 

Sec. 

* * * * * 

721.11925 1(2H)-Naphthalenone,4- 

ethyloctahydro-8-methyl. 

721.11926 Propanoic acid, 2,2-dimethyl-,-1- 

methyl-2-(1-methylethoxy)-2-oxoethyl 

ester. 

721.11927 1,3-Propanediol,2-methylene-, 

substituted (generic). 

721.11928 Alkyl oil, polymer with 1,4- 

cyclohexanedimethanol, dehydrated 

Alkyl oil, hydrogenated rosin, phthalic 

anhydride and trimethylolpropane 

(generic). 

721.11929 Polyphosphoric acids, polymers 

with (alkoxyalkoxy)alkanol and 

substituted heteromonocycle (generic). 

721.11930 Tertiary amine, compounds with 

amino sulfonic acid blocked aliphatic 

isocyanate homopolymer (generic). 

721.11931 Carboxylic acid-polyamine 

condensate (generic). 

721.11932 Alkaneamine, (aminoalkyl)-, 

polymer with aziridine and 1,6- 

diisocyanatohexane, polyethylene glycol 

alkyl ether- and polyethylenepolypropylene glycol aminoalkyl alkyl 

ether- and alkenyl benzenated 

polyethylene glycol Ph ether (generic). 

721.11933 Branched alkanoic acid, epoxy 

ester, reaction products with monocyclic 

dialkylamine and polycyclic alcohol 

epoxy polymer (generic). 

721.11934 Branched alkanoic acid, epoxy 

ester, reaction products with 

monocyclicdialkanamine and polycyclic 

dialkanol ether polymer (generic). 

721.11935 Branched alkanoic acid, epoxy 

ester, reaction products with 

monocyclicalkanamine, polycyclic 

alcohol ether homopolymer, and 

polycyclic alcohol epoxy polymer 

(generic). 

721.11936 Thiosulfuric acid, aminoalkyl 

ester (generic). 

721.11937 Butanoic acid ethyl amine 

(generic). 

721.11938 Alkenoic acid, alkyl-substituted, 

epoxy ester, polymer with alkyl 

alkenoate, alkene, and polylactide 

(generic). 

721.11939 Alkenoic acid, alkyl, polymer 

with carbomonocyle alkyl propenoate 

and substituted alkyl alkenoate, ester 

with substituted alkyl alkanoate, 

tertbutyl substituted peroxoate-initiated 

(generic). 

721.11940 [5-isocyanato-1- 

(isocyanatomethyl)-1,3,3- 

trimethylcyclohexane], 

[Poly[oxy(methyl-1,2-ethanediyl)], 

.alpha.-hydro-.omega.-hydroxy-, polymer 

with 1,6-diisocyanatohexane], polymer 

with [Poly(oxy-1,4-butanediyl), .alpha.- 

hydro-.omega.-hydroxy-], [Cyclic 

amine—ketone adduct, reduced], and 

[1,3-Propanediol, 2-ethyl-2- 

(hydroxymethyl)-] (generic). 

721.11941 Alkanol amine salt mixture 

(generic). 

721.11942 Heteroatom-substituted alkyl 

triethoxysilane, reaction products with 

methylated formaldehyde-melamine 

polymer (generic). 

721.11943 Fatty acids, polymers with 

alkanediol and 1,1′-methylenebis[4- 

isocyanatobenzene] (generic). 

721.11944 7-Heteropolycyclicsulfonic acid, 

2-[4-[2-[1-[[(2-methoxy-5-methyl-4- 

sulfophenyl)amino]carbonyl]-2- 

oxopropyl]diazenyl]phenyl]-6-methyl-, 

compd. with (alkylamino)alkanol and 

(hydroxyalkyl)amine (generic). 

721.11945 Polyol, polymer with alkyl 

diisocyanate, alkyl substituted 

heterocycle blocked (generic). 

721.11946 Polyalkoxycarbopolycycle 

hydroxy (generic). 

721.11947 Glycols, .alpha., .omega.-, C2-6, 

polymers with adipic acid, 

dodecanedioic acid, hydracrylic acid 

polyester, isophthalic acid, isophthalic 

acid, 1,1′-methylenebis[4- 

isocyanatobenzene], neopentyl glycol 

and terephthalic acid (generic). 

721.11948 Glycols, .alpha., .omega.-, C2-6, 

polymers with adipic acid, aromatic 

polyester, dodecanedioic acid, 

hydracrylic acid polyester, isophthalic 

acid, 1,1′-methylenebis[4- 

isocyanatobenzene], neopentyl glycol 

and terephthalic acid (generic). 

721.11949 Benzenepentanol, alpha, gammadimethyl. 

721.11950 Nitrile hydratase. 

721.11951 Polyphosphoric acids, 2-[(alkyl1-oxo-alkene-1-yl)oxy]alkyl esters, 

polymers with acrylic acid, alkyl 

acrylate, alkyl methacrylate, 

hydroxyalkyl methacrylate and 

carbomonocycle, 2,2′-(1,2- 

diazenediyl)bis[2,4- 

dialkylalkanenitrogensubstituted]- 

initiated (generic). 

721.11952 Arene, trimethoxysilyl-, 

hydrolyzed (generic). 

721.11953 2-Propenoic acid, 2-methyl-, 

polymer with 2-hydroxyethyl 2-methyl2-propenoate phosphate and 2-propenoic 

acid salt, peroxydisulfuric acid 

([(HO)S(O)2]2O2) sodium salt (1:2)- and 

sodium (disulfite) (2:1)-initiated 

(generic). 

721.11954 Oxirane, 2-methyl-, polymer 

with oxirane, monoundecyl ether, 

branched and linear. 

* * * * * 


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§ 721.11925 1(2H)-Naphthalenone,4- 

ethyloctahydro-8-methyl. 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified as 

1(2H)-naphthalenone,4-ethyloctahydro8-methy (PMN P–15–633; CAS No. 

870515–09–6) is subject to reporting 

under this section for the significant 

new uses described in paragraph (a)(2) 

of this section. 

(2) The significant new uses are: 

(i) Release to water. Requirements as 

specified in § 721.90(a)(4), (b)(4), and 

(c)(4), where N=43. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (k) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11926 Propanoic acid, 2,2-dimethyl-,- 

1-methyl-2-(1-methylethoxy)-2-oxoethyl 

ester. 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified as 

propanoic acid, 2,2-dimethyl-,-1- 

methyl-2-(1-methylethoxy)-2-oxoethyl 

ester (PMN P–16–326; CAS No. 

1821051–37–9) is subject to reporting 

under this section for the significant 

new uses described in paragraph (a)(2) 

of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to process the substance above 

1% in formulation for consumer 

products. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11927 1,3-Propanediol,2-methylene-, 

substituted (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as 1,3-propanediol,2- 

methylene-, substituted (PMN P–17– 

195) is subject to reporting under this 

section for the significant new uses 

described in paragraph (a)(2) of this 

section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80(g). 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11928 Alkyl oil, polymer with 1,4- 

cyclohexanedimethanol, dehydrated Alkyl 

oil, hydrogenated rosin, phthalic anhydride 

and trimethylolpropane (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as alkyl oil, polymer with 

1,4-cyclohexanedimethanol, dehydrated 

alkyl oil, hydrogenated rosin, phthalic 

anhydride and trimethylolpropane 

(PMN P–17–389) is subject to reporting 

under this section for the significant 

new uses described in paragraph (a)(2) 

of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to manufacture, process, or use 

the substance in a manner that results 

in inhalation exposure. 

(ii) Release to water. Requirements as 

specified in § 721.90(a)(4), (b)(4), and 

(c)(4), where N=39. 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), (i), and (k) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11929 Polyphosphoric acids, 

polymers with (alkoxyalkoxy)alkanol and 

substituted heteromonocycle (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as polyphosphoric acids, 

polymers with (alkoxyalkoxy)alkanol 

and substituted heteromonocycle (PMN 

P–18–98) is subject to reporting under 

this section for the significant new uses 

described in paragraph (a)(2) of this 

section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to process the substance to 

greater than 5% by weight in the final 

formulated product for any use. 

(ii) Release to water. Requirements as 

specified in § 721.90(a)(4), (b)(4), and 

(c)(4), where N=16. 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), (i), and (k) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11930 Tertiary amine, compounds 

with amino sulfonic acid blocked aliphatic 

isocyanate homopolymer (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as tertiary amine, 

compounds with amino sulfonic acid 

blocked aliphatic isocyanate 

homopolymer (PMN P–18–150) is 

subject to reporting under this section 

for the significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Protection in the workplace. 

Requirements as specified in 

§ 721.63(a)(4) and (5), and (c). When 

determining which persons are 

reasonably likely to be exposed as 

required for § 721.63(a)(4), engineering 

control measures (e.g., enclosure of 

confinement of the operation, general 

and local ventilation) or administrative 

control measures (e.g., workplace 

policies and procedures) shall be 

considered and implemented to prevent 

exposure, where feasible). For purposes 

of § 721.63(a)(5), respirators must 

provide a National Institute for 

Occupational Safety and Health 

(NIOSH) assigned protection factor 

(APF) of at least 10. 

(ii) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80(f) and (j). 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 


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§ 721.125(a) through (d), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11931 Carboxylic acid-polyamine 

condensate (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as carboxylic acidpolyamine condensate (PMN P–18–187) 

is subject to reporting under this section 

for the significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to manufacture, process, or use 

the substance in a manner that results 

in inhalation exposure. 

(ii) Release to water. Requirements as 

specified in § 721.90(a)(4), (b)(4), and 

(c)(4), where N=1. 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), (i), and (k) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11932 Alkaneamine, (aminoalkyl)-, 

polymer with aziridine and 1,6- 

diisocyanatohexane, polyethylene glycol 

alkyl ether- and polyethylene-polypropylene 

glycol aminoalkyl alkyl ether- and alkenyl 

benzenated polyethylene glycol Ph ether 

(generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as alkaneamine, 

(aminoalkyl)-, polymer with aziridine 

and 1,6-diisocyanatohexane, 

polyethylene glycol alkyl ether- and 

polyethylene-polypropylene glycol 

aminoalkyl alkyl ether- and alkenyl 

benzenated polyethylene glycol Ph ether 

(PMN P–18–211) is subject to reporting 

under this section for the significant 

new uses described in paragraph (a)(2) 

of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80(o). It is a 

significant new use to use the substance 

in spray applications. 

(ii) Release to water. Requirements as 

specified in § 721.90(a)(4), (b)(4), and 

(c)(4), where N=16. 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), (i), and (k) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11933 Branched alkanoic acid, 

epoxy ester, reaction products with 

monocyclic dialkylamine and polycyclic 

alcohol epoxy polymer (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as branched alkanoic acid, 

epoxy ester, reaction products with 

monocyclic dialkylamine and 

polycyclic alcohol epoxy polymer (PMN 

P–18–267) is subject to reporting under 

this section for the significant new uses 

described in paragraph (a)(2) of this 

section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to use the substance in a spray 

application method where more than 

1% of particles are less than 10 microns 

in diameter. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11934 Branched alkanoic acid, 

epoxy ester, reaction products with 

monocyclicdialkanamine and polycyclic 

dialkanol ether polymer (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as branched alkanoic acid, 

epoxy ester, reaction products with 

monocyclicdialkanamine and polycyclic 

dialkanol ether polymer (PMN P–18– 

268) is subject to reporting under this 

section for the significant new uses 

described in paragraph (a)(2) of this 

section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to use the substance in a spray 

application method where more than 

1% of particles are less than 10 microns 

in diameter. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11935 Branched alkanoic acid, 

epoxy ester, reaction products with 

monocyclicalkanamine, polycyclic alcohol 

ether homopolymer, and polycyclic alcohol 

epoxy polymer (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as branched alkanoic acid, 

epoxy ester, reaction products with 

monocyclicalkanamine, polycyclic 

alcohol ether homopolymer, and 

polycyclic alcohol epoxy polymer (PMN 

P–18–269) is subject to reporting under 

this section for the significant new uses 

described in paragraph (a)(2) of this 

section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to use the substance in a spray 

application where more than 1% of 

particles are less than 10 microns in 

diameter. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11936 Thiosulfuric acid, aminoalkyl 

ester (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as thiosulfuric acid, 

aminoalkyl ester (PMN P–18–376) is 

subject to reporting under this section 

for the significant new uses described in 

paragraph (a)(2) of this section. 


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(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80(f). It is a significant 

new use to use the substance other than 

for incorporating into rubber products. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11937 Butanoic acid ethyl amine 

(generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as butanoic acid ethyl amine 

(PMN P–18–380) is subject to reporting 

under this section for the significant 

new uses described in paragraph (a)(2) 

of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80(f). It is a significant 

new use to import the substance other 

than in the confidential form described 

in the PMN. It is a significant new use 

to process the substance in end use 

formulations greater than the 

confidential concentration percentage 

identified in the PMN. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11938 Alkenoic acid, alkylsubstituted, epoxy ester, polymer with alkyl 

alkenoate, alkene, and polylactide (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as alkenoic acid, alkylsubstituted, epoxy ester, polymer with 

alkyl alkenoate, alkene, and polylactide 

(PMN P–18–389) is subject to reporting 

under this section for the significant 

new uses described in paragraph (a)(2) 

of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to manufacture, process, or use 

the substance in a manner that results 

in inhalation exposure. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11939 Alkenoic acid, alkyl, polymer 

with carbomonocyle alkyl propenoate and 

substituted alkyl alkenoate, ester with 

substituted alkyl alkanoate, tertbutyl 

substituted peroxoate-initiated (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as alkenoic acid, alkyl, 

polymer with carbomonocyle alkyl 

propenoate and substituted alkyl 

alkenoate, ester with substituted alkyl 

alkanoate, tertbutyl substituted 

peroxoate-initiated (PMN P–18–396) is 

subject to reporting under this section 

for the significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80(j) and (o). 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11940 [5-isocyanato-1- 

(isocyanatomethyl)-1,3,3- 

trimethylcyclohexane], [poly[oxy(methyl1,2-ethanediyl)], .alpha.-hydro-.omega.- 

hydroxy-, polymer with 1,6- 

diisocyanatohexane], polymer with 

[poly(oxy-1,4-butanediyl), .alpha.-hydro- 

.omega.-hydroxy-], [cyclic amine—ketone 

adduct, reduced], and [1,3-propanediol, 2- 

ethyl-2-(hydroxymethyl)-] (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as [5-isocyanato-1- 

(isocyanatomethyl)-1,3,3- 

trimethylcyclohexane], 

[poly[oxy(methyl-1,2-ethanediyl)], 

.alpha.-hydro-.omega.-hydroxy-, 

polymer with 1,6-diisocyanatohexane], 

polymer with [poly(oxy-1,4-butanediyl), 

.alpha.-hydro-.omega.-hydroxy-], [cyclic 

amine—ketone adduct, reduced], and 

[1,3-propanediol, 2-ethyl-2- 

(hydroxymethyl)-] (PMN P–19–134) is 

subject to reporting under this section 

for the significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80(o). 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11941 Alkanol amine salt mixture 

(generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as alkanol amine salt 

mixture (PMN P–19–161) is subject to 

reporting under this section for the 

significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80(o). 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11942 Heteroatom-substituted alkyl 

triethoxysilane, reaction products with 

methylated formaldehyde-melamine 

polymer (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 


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generically as heteroatom-substituted 

alkyl triethoxysilane, reaction products 

with methylated formaldehydemelamine polymer (PMN P–19–170) is 

subject to reporting under this section 

for the significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to manufacture, process, or use 

the substance in a manner that results 

in inhalation exposure. It is a significant 

new use to use the substance other than 

as a coupling agent in elastomer-based 

formulations that will be used in 

molding operations to manufacture 

different types of rubber articles 

including but not limited to rubber tires. 

(ii) Releases to water. Requirements as 

specified in § 721.90(a)(1), (b)(1), and 

(c)(1). 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), (i), and (k) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11943 Fatty acids, polymers with 

alkanediol and 1,1′-methylenebis[4- 

isocyanatobenzene] (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as fatty acids, polymers with 

alkanediol and 1,1′-methylenebis[4- 

isocyanatobenzene] (PMN P–19–189) is 

subject to reporting under this section 

for the significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80. It is a significant 

new use to use the substance other than 

as a reactive polymer for use in 

adhesives and sealants. It is a significant 

new use to manufacture, process, or use 

the substance in a manner that results 

in inhalation exposure. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11944 7-Heteropolycyclicsulfonic 

acid, 2-[4-[2-[1-[[(2-methoxy-5-methyl-4- 

sulfophenyl)amino]carbonyl]-2- 

oxopropyl]diazenyl]phenyl]-6-methyl-, 

compd. with (alkylamino)alkanol and 

(hydroxyalkyl)amine (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as 7- 

heteropolycyclicsulfonic acid, 2-[4-[2- 

[1-[[(2-methoxy-5-methyl-4- 

sulfophenyl)amino]carbonyl]-2- 

oxopropyl]diazenyl]phenyl]-6-methyl-, 

compd. with (alkylamino)alkanol and 

(hydroxyalkyl)amine (PMN P–20–8) is 

subject to reporting under this section 

for the significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80. It is a significant 

new use to use the substance other than 

as a dye for use with paper, paper 

products, and nonwoven products 

produced from paper. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11945 Polyol, polymer with alkyl 

diisocyanate, alkyl substituted heterocycle 

blocked (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as polyol, polymer with 

alkyl diisocyanate, alkyl substituted 

heterocycle blocked (PMN P–20–12) is 

subject to reporting under this section 

for the significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Release to water. Requirements as 

specified in § 721.90(a)(4), (b)(4), and 

(c)(4), where N=5. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (k) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11946 Polyalkoxycarbopolycycle 

hydroxy (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as polyalkoxycarbopolycycle 

hydroxy (PMN P–20–22) is subject to 

reporting under this section for the 

significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to manufacture, process, or use 

the substance in a manner that results 

in inhalation exposure. 

(ii) Release to water. Requirements as 

specified in § 721.90(a)(4), (b)(4), and 

(c)(4), where N=44. 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), (i), and (k) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11947 Glycols, .alpha.,.omega.-, C2– 

6, polymers with adipic acid, dodecanedioic 

acid, hydracrylic acid polyester, isophthalic 

acid, isophthalic acid, 1,1′-methylenebis[4- 

isocyanatobenzene], neopentyl glycol and 

terephthalic acid (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as glycols, .alpha.,.omega.-, 

C2–6, polymers with adipic acid, 

dodecanedioic acid, hydracrylic acid 

polyester, isophthalic acid, isophthalic 

acid, 1,1′-methylenebis[4- 

isocyanatobenzene], neopentyl glycol 

and terephthalic acid (PMN P–20–27) is 

subject to reporting under this section 

for the significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80(o). It is a 

significant new use to manufacture, 

process, or use the substance in a 

manner that results in inhalation 

exposure. 

(ii) Releases to water. Requirements as 

specified in § 721.90(a)(1), (b)(1), and 

(c)(1). 


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(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), (i), and (k) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11948 Glycols, .alpha.,.omega.-, C2– 

6, polymers with adipic acid, aromatic 

polyester, dodecanedioic acid, hydracrylic 

acid polyester, isophthalic acid, 1,1′- 

methylenebis[4-isocyanatobenzene], 

neopentyl glycol and terephthalic acid 

(generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as glycols, .alpha.,.omega.-, 

C2–6, polymers with adipic acid, 

aromatic polyester, dodecanedioic acid, 

hydracrylic acid polyester, isophthalic 

acid, 1,1′-methylenebis[4- 

isocyanatobenzene], neopentyl glycol 

and terephthalic acid (PMN P–20–28) is 

subject to reporting under this section 

for the significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80(o). It is a 

significant new use to manufacture, 

process, or use the substance in a 

manner that results in inhalation 

exposure. 

(ii) Releases to water. Requirements as 

specified in § 721.90(a)(1), (b)(1), and 

(c)(1). 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), (i), and (k) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11949 Benzenepentanol, alpha, 

gamma-dimethyl. 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified as 

benzenepentanol, alpha, gammadimethyl (PMN P–20–50; CAS No. 

72681–01–7) is subject to reporting 

under this section for the significant 

new uses described in paragraph (a)(2) 

of this section. 

(2) The significant new uses are: 

(i) Release to water. Requirements as 

specified in § 721.90(a)(4), (b)(4), and 

(c)(4), where N=71. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (k) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11950 Nitrile hydratase. 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified as 

nitrile hydratase (PMN P–20–54, CAS 

No. 82391–37–5) is subject to reporting 

under this section for the significant 

new uses described in paragraph (a)(2) 

of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to manufacture, process, or use 

the substance in a manner that results 

in inhalation exposure. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11951 Polyphosphoric acids, 2- 

[(alkyl-1-oxo-alkene-1-yl)oxy]alkyl esters, 

polymers with acrylic acid, alkyl acrylate, 

alkyl methacrylate, hydroxyalkyl 

methacrylate and carbomonocycle, 2,2′- 

(1,2-diazenediyl)bis[2,4- 

dialkylalkanenitrogensubstituted]-initiated 

(generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as polyphosphoric acids, 2- 

[(alkyl-1-oxo-alkene-1-yl)oxy]alkyl 

esters, polymers with acrylic acid, alkyl 

acrylate, alkyl methacrylate, 

hydroxyalkyl methacrylate and 

carbomonocycle, 2,2′-(1,2- 

diazenediyl)bis[2,4- 

dialkylalkanenitrogensubstituted]- 

initiated (PMN P–20–56) is subject to 

reporting under this section for the 

significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Release to water. Requirements as 

specified in § 721.90(a)(4), (b)(4), and 

(c)(4), where N=1. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (k) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11952 Arene, trimethoxysilyl-, 

hydrolyzed (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as arene, trimethoxysilyl-, 

hydrolyzed (PMN P–20–57) is subject to 

reporting under this section for the 

significant new uses described in 

paragraph (a)(2) of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to manufacture, process, or use 

the PMN substance in a manner that 

results in inhalation exposure. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11953 2-Propenoic acid, 2-methyl-, 

polymer with 2-hydroxyethyl 2-methyl-2- 

propenoate phosphate and 2-propenoic 

acid salt, peroxydisulfuric acid 

([(HO)S(O)2]2O2) sodium salt (1:2)- and 

sodium (disulfite) (2:1)-initiated (generic). 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified 

generically as 2-propenoic acid, 2- 

methyl-, polymer with 2-hydroxyethyl 

2-methyl-2-propenoate phosphate and 

2-propenoic acid salt, peroxydisulfuric 

acid ([(HO)S(O)2]2O2) sodium salt (1:2)- 

and sodium (disulfite) (2:1)-initiated 

(PMN P–20–69) is subject to reporting 

under this section for the significant 


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79220 Federal Register / Vol. 89, No. 188 / Friday, September 27, 2024 / Proposed Rules 

new uses described in paragraph (a)(2) 

of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. Requirements as 

specified in § 721.80(j). 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

§ 721.11954 Oxirane, 2-methyl-, polymer 

with oxirane, monoundecyl ether, branched 

and linear. 

(a) Chemical substance and 

significant new uses subject to reporting. 

(1) The chemical substance identified as 

oxirane, 2-methyl-, polymer with 

oxirane, monoundecyl ether, branched 

and linear (PMN P–20–74; CAS No. 

2222805–23–2) is subject to reporting 

under this section for the significant 

new uses described in paragraph (a)(2) 

of this section. 

(2) The significant new uses are: 

(i) Industrial, commercial, and 

consumer activities. It is a significant 

new use to use the substance other than 

as a surfactant for use in the formulation 

of pesticide products. It is a significant 

new use to manufacture, process, or use 

the substance in a manner that results 

in inhalation exposure. 

(ii) [Reserved] 

(b) Specific requirements. The 

provisions of subpart A of this part 

apply to this section except as modified 

by this paragraph (b). 

(1) Recordkeeping. Recordkeeping 

requirements as specified in 

§ 721.125(a) through (c), and (i) are 

applicable to manufacturers and 

processors of this substance. 

(2) Limitation or revocation of certain 

notification requirements. The 

provisions of § 721.185 apply to this 

section. 

* * * * * 

[FR Doc. 2024–22168 Filed 9–26–24; 8:45 am] 

BILLING CODE 6560–50–P 

DEPARTMENT OF COMMERCE 

National Oceanic and Atmospheric 

Administration 

50 CFR Part 622 

[Docket No. 240919–0244] 

RIN 0648–BN06 

Fisheries of the Caribbean, Gulf of 

Mexico, and South Atlantic; Fishery 

Management Plans of Puerto Rico, St. 

Croix, and St. Thomas and St. John; 

Amendment 3 

AGENCY: National Marine Fisheries 

Service (NMFS), National Oceanic and 

Atmospheric Administration (NOAA), 

Commerce. 

ACTION: Proposed rule; request for 

comments. 

SUMMARY: NMFS proposes to implement 

management measures described in 

Amendment 3 to the Fishery 

Management Plans (FMPs) for Puerto 

Rico, St. Croix, and St. Thomas and St. 

John, as prepared by the Caribbean 

Fishery Management Council (Council) 

(Amendment 3). If implemented, this 

proposed rule would establish new 

management measures for dolphinfish 

(Coryphaena hippurus) and wahoo 

(Acanthocybium solandri) in U.S. 

Caribbean Federal waters, including 

commercial and recreational minimum 

size limits and recreational bag and 

possession limits. The purpose of this 

proposed rule and Amendment 3 is to 

develop management measures to 

ensure dolphinfish and wahoo have 

adequate time to mature and reproduce 

and to take a precautionary approach to 

management to protect against 

overfishing. 

DATES: Written comments must be 

received no later than October 28, 2024. 

ADDRESSES: A plain language summary 

of this proposed rule is available at 

https://www.regulations.gov/docket/ 

NOAA-NMFS-2024-0070. You may 

submit comments on this document, 

identified by ‘‘NOAA–NMFS–2024– 

0070’’ by either of the following 

methods: 

• Electronic Submission: Submit all 

electronic public comments via the 

Federal e-Rulemaking Portal. Visit 

https://www.regulations.gov and type 

‘‘NOAA–NMFS–2024–0070’’ in the 

Search box. Click on the ‘‘Comment’’ 

icon, complete the required fields, and 

enter or attach your comments. 

• Mail: Submit written comments to 

Sarah Stephenson, Southeast Regional 

Office, NMFS, 263 13th Avenue South, 

St. Petersburg, FL 33701. 

Instructions: Comments sent by any 

other method, to any other address or 

individual, or received after the end of 

the comment period, may not be 

considered by NMFS. All comments 

received are a part of the public record 

and will generally be posted for public 

viewing on https://www.regulations.gov 

without change. All personal identifying 

information (e.g., name, address, etc.), 

confidential business information, or 

otherwise sensitive information 

submitted voluntarily by the sender will 

be publicly accessible. NMFS will 

accept anonymous comments (enter ‘‘N/ 

A’’ in the required fields if you wish to 

remain anonymous). 

An electronic copy of Amendment 3, 

which includes a fishery impact 

statement, an environmental 

assessment, a regulatory impact review, 

and a Regulatory Flexibility Act (RFA) 

analysis, may be obtained from the 

Southeast Regional Office website at 

https://www.fisheries.noaa.gov/action/ 

amendment-3-puerto-rico-st-croix-andst-thomas-and-st-john-fisherymanagement-plans. 

FOR FURTHER INFORMATION CONTACT: 

Sarah Stephenson, 727–824–5305, 

sarah.stephenson@noaa.gov. 

SUPPLEMENTARY INFORMATION: NMFS, 

with the advice of the Council, manages 

the Puerto Rico, St. Croix, and St. 

Thomas and St. John fisheries in U.S. 

Caribbean Federal waters under the 

Puerto Rico, St. Croix, and St. Thomas 

and St. John FMPs. The Council 

prepared the FMPs, which the Secretary 

of Commerce approved, and NMFS 

implements the FMPs through 

regulations at 50 CFR part 622 under the 

authority of the Magnuson-Stevens 

Fishery Conservation and Management 

Act (Magnuson-Stevens Act). 

Background 

The Magnuson-Stevens Act requires 

NMFS and the regional fishery 

management councils to prevent 

overfishing and achieve, on a 

continuing basis, the optimum yield 

from federally managed fish stocks to 

ensure that fishery resources are 

managed for the greatest overall benefit 

to the Nation, particularly with respect 

to providing food production and 

recreational opportunities, and 

protecting marine ecosystems. 

On September 22, 2020, the Secretary 

of Commerce approved the Puerto Rico, 

St. Croix, and St. Thomas and St. John 

FMPs under section 304(a)(3) of the 

Magnuson-Stevens Act. The FMPs took 

effect on October 13, 2022, after NMFS 

published the final rule to implement 

the FMPs (87 FR 56204, September 13, 

2022). Each FMP contains management 


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