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UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

D A Z Office of Air Quality Planning and Standards

Research Triangle Park, North Carolina 2771 1

;~"'9 Pqo,~< ~r August 11, 1993

MEMORANDUM

SUBJECT : Subject Data Supplied by the Researchers for the Recent

Controlled Human Studies Analyzed in the Staff Paper

Supplement and Accomp nying Memorandum

FROM : Eric Smith

Ambient Standards Branch ( MD-12 )

TO : The SO2 Docket ( A-84-25 )

The contents of item IV-B-5, Docket No . A-84-25 are

explained below .

iLen~ Iti- b- ~) is C uiupuseu uL Liitee pdrts, ts ana L :

Item IV-B-5, part A is composed of copies of spreadsheets

containing the information from the raw data supplied in Item IVB-5, part B, as entered into a computer for calculations by EPA

staff . These are the numbers used to perform the calculations

detailed in the draft Staff Paper Supplement and the memorandum

entitled "Analysis of Recent SO2 Controlled Human Studies ."

Summaries of lung function information from these spreadsheets

were provided as Attachment 3 to that memorandum .

For the symptom spreadsheets, the column of "Exc" symptoms

records the maximum symptoms at exercise, and thus may equal the

SO2 symptom score but not "cancel it out," if the SO2 symptoms

score was reported for an different one of the three symptom

categories ( chest tightness/discomfort, shortness of

breath/breathlessness, and wheeze) . The original sheets need to

be referred to in these cases to check on the final symptom score

tabulations . X's next to scores denote when pre-exposure scores

equaled post-exposure scores . ( These X's "cancel out" SO2

symptoms, and exercise symptoms when tabulated separately, but

not when determining if exercise symptoms total SO2 symptoms for

the "Final Symptom Scores After Correction" table . See the

memorandum "Analysis of Recent SO, Controlled Human Studies" if

more information is desired on how these values were used to

determine the final symptoms scores . For the final symptom

scores, scores of both "0" and "5" were treated as "0" for

simplicity, since neither were counted as symptoms in the final

analyses .
p. 2

2

Item IV-B-5, part B contains the original data from which

the numbers in the spreadsheets were obtained :

The lung function data for the Roger et al . (1985) study is

in the form of a handwritten summary sheet provided to me by Dr .

Howard Kehrl of HERL . The symptoms data is provided in the form

of subject by subject computer printouts, as provided to me by

Dr . Don Hortsman of HERL . The information on these sheets is

coded as follows, as detailed on the sheet for Subj . 001 :

Cohort 1 - 0 .0 ppm Clean Air Exposure

Cohort 2 - 0 .25 ppm SO2 exposure

Cohort 3 - 0 .5 ppm SO2 exposure

Cohort 4 - 1 .0 ppm SO2 exposure

Cohort 5 - 2 .0 ppm SO2 exposure

Sywp ~u,«z=, 6d La was useu Z .Luiu Session u tor pre-exposure

symptoms and Session 1 for post-exposure symptoms, which Dr . Don

Horstman communicated to me was the symptoms report occurring

after the lst exercise period .

The lung function and symptoms data from Linn et al . (1987,

1988, and 1990), is coded as follows, as detailed in the copy of

the handwritten sheet provided for me by Dr . William Linn which

is included with the data (I have added the information for the

1988 and 1990 subject data to the sheet myself as per information

I received from Dr . Linn for these groups) . The exposures are

coded by the number given for "Cond ." or "Exposure Code", with a

given exposure code signifying a different exposure for subjects

in varying subject groups :

Group 258 Clean air (Rl, R2) - 1, 5

0 .2 ppm SO2 (Rl, R2) - 3, 7

0 .4 ppm SO2 (R1, R2) - 4, 8

0 .6 ppm SO2 (R1, R2) - 2, 6

Group 259 Clean air (Ri, R2) - 3, 8

0 .2 ppm SO2 (Rl, R2) - 1, 6

0 .4 ppm SO2 (R1, R2) - 2, 5

0 . 6 ppm SO2 (R1, R2) - 4, 7

Group 260 Clean air (R1, R2) - 1, 6

0 .2 ppm SO2 (R1, R2) - 4, 7

0 . 4 ppm SO2 (RI, R2) - 3, 8

0 .6 ppm SO2 (Ri, R2) - 2, 5
p. 3

3

Group 262 Clean air (R1, R2) - 4, 5

0 .2 ppm SO2 (R1, R2) - 3, 8

0 .4 ppm SO2 (R1, R2) - 1, 6

0 .6 ppm SO2 (Rl, R2) - 2, 7

Group 267 Clean air (R1, R2) - 3, 8

0 . 2 ppm SO2 (R1, R2) - 2, 7

0 . 4 ppm SO2 (R1, R2) - 1, 5

0 .6 ppm SOz (R1, R2) - 4, 6

Group 271 Clean air (Rl, R2) - 2, 6

0 . 2 ppm SO2 (Rl, R2) - 3, 8

0 .4 ppm SO2 (R1, R2) - 4, 5

0 .6 ppm SO2 (Rl, R2) - 1, 7

Group 277 Clean air, untreated - 5

(1988 study) 0 .3 ppm SO2, untreated - 1

0 .6 ppm SO2, untreated - 7

Clean air, placebo - 3

0 .3 ppm SO2, placebo - 9

0 .6 ppm SO2, placebo - 2

Clean air, drug - 8

0 .3 ppm SO2, drug - 6

0 .6 ppm SO2, drug - 4

Group 281 Clean air, low medications - 7

(1990 study) 0 .3 ppm SO2, low medications - 4

0 .6 ppm SO2, low medications - 1

Clean air, normal medications - 8

0 .3 ppm SO2, normal medications - 5

0 .6 ppm SO2, normal medications - 2

Clean air, high medications - 9

0 .3 ppm SO2, high medications - 6

0 .6 ppm SO2, high medications - 3

The Linn et al . (1988) study is also referred to on the

original sheets as the 1987 SO2 Medications Study, and the Linn

et al . (1990) study is also referred to as the 1988 SO2

Medication Study, since these were when the studies were carried

out (but not published) .

The Linn et al . (1988) study SRaw data was provided as a

computer printout which was read in the following fashion :

Observations 12 (before exposure, after pretreatment) and 13

(after exposure) gave pre-and post-Sraw values for clean

air, untreated . Observations 72 (before exposure, after

pretreatment) and Observations 73 (after exposure) gave pre-
p. 4

4

and post-Sraw values for 0 .6 ppm . This is as described on

the sheet "Appendix : Specific Airway Resistance Data for

Individual Subjects" as provided to me by Dr . Linn and

included amongst the materials .

From the symptoms sheets, scores were recorded from "Right

Now" for pre-exposure symptoms and "Exercise I" for post-exposure

symptoms for the Linn et al . (1987) study ; from "In Chamber/Post

Meds Test" (Card 5) for pre-exposure symptoms and "O n

Exiting/Exercise" (Card 6) for post-exposure symptoms for the

Linn et al . (1988) study ; and "30 Min . Post Meds Test" for preexposure symptoms and "40 Min . Exercise" for post-exposure

symptoms for the Linn et al . (1990) study .

Item IV-B-5, part C contains copies of written

correspondence between myself and the Rancho Los Amigos

researchers concerning this data .

The symptoms data as contained in part B contain the

revisions or additional information for a few subjects that I had

requested and that was supplied to me by Dr . Linn and Dr . Deborah

Shamoo in response to my request on June 22, 1993 . In some cases

they jotted down scores for certain subjects and conditions, but

since they were unaware of the periods (e .g ., "Exercise I") for

which I was scoring symptoms, I did not use those number as sent

directly . Instead I used those numbers to figure out which

conditions should be assigned to which trials amongst the sheets

I already had, or in most cases they sent along the original

sheets again for clarification . So, I revised my sheets by

taking into account the information they provided me or inserting

additional raw data sheets which were sent for some of the

subjects when I needed them . The lung function data required no

revisions as per the communication on July 2, 1993, because this

correspondence simply confirmed that the raw data sheets they had

sent me contained the accurate lung function scores .
p. 5

ROGER ET AL., 1985 A-1

MILD ASTHMATICS

1 .0 PPM S02 Rank

S02 Total EXC EXC Adj S02

Subj . PreExp PostExp SRaw PreExp PostExp SRaw SRaw SRaw

1 6.43 10.40 61 .74 6.34 6.52 2.84 58.90 516 .19

3 6

4 5

.43 13.40 108.40 9.56 14.87 55.54 52.85 420.83

.88 14.88 153.06 11 .54 17.74 53.73 99.34 343.40

7 4.53 12.45 174 .83 5.05 7.20 42.57 132 .26 304.24

12 10.23 9.94 -2.83 8.20 5.51 -32 .80 29.97 289.07

13 2.99 7.25 142 .47 4.60 4.94 7.39 135.08~ 256 .75

14 6.70 13.03 94.48 2.82 3.71 31 .56 62.92 249 .37

15 5.02 17.85 255 .58 4.67 4.96 6.21 249.37 170 .06

16 2.84 5.68 100 .00 2.90 3.15 8.62 91 .38 162 .53

18 4.65 8.31 78.71 4.65 4.98 7.10 71 .61 135 .83

19 9.93 44.94 352 .57 10.14 15.04 48.32 304 .24 135 .08

20 from 0.5 ppm 4.58 34.97 663.54 2.83 7.00 147 .35 516 .19 132 .26

23 7.62 27.93 266.54 8.58 9.42 9.79 256 .75 127 .00

24 4.31 13.30 208.58 4.62 6.40 38.53 170 .06 109.18

26 4.37 12.00 174 .60 2.76 3.83 38.77 135 .83 99.34

29 11.42 67.88 494 .40 13.28 23.05 73.57 420 .83 91 .38

30 6.14 19.61 219 .38 6.86 10.76 56.85 162 .53 81 .46

36 3.55 4.51 27.04 3.74 4.14 10.70 16.35 81 .28

37 6.65 20.24 204 .36 7.49 19.61 161 .82 42.55 71 .61

39 5.95 14.36 141 .34 5.91 9.46 60.07 81 .28 62.92

40 9.36 15.00 60.26 8.13 9.00 10.70 49.56 58.90

42 6.00 10.39 73.17 5.81 7.79 34.08 39.09 52.85

43 5.35 29.45 450.47 5.44 14.22 161 .40 289 .07 49.56

44 8.39 15.49 84.62 8.53 8.80 3.17 81 .46 42.55

45 10.20 32.21 215 .78 4.39 9.07 106 .61 109 .18 39.09

46 8.16 40.18 392 .40 5.51 8.21 49.00 343 .40 29.97

48 5.06 7.89 55.93 4.68 7.22 54.27 1 .66 16.35

50 4.35 14.34 229 .66 5.27 10.68 102 .66 127 .00 1 .66

AVG W/# 20 195.75 48.23 147 .52
p. 6

ROGER ET AL ., 1985

MILD ASTHMATIC S

0 .5 PPM S02 Rank

S02 Total EXC EXC Adj S02

Subj . PreExp PostExp SRaw PreExp PostExp SRaw SRaw SRaw

1 7.08 6.31 -10.88 6.34 6.52 2.84 -13.71 516 .19

3 7.08 10.05 41 .95 9.56 14.87 55.54 -13 .59 196 .18

4 8.57 21 .66 152.74 11 .54 17.74 53.73 99 .02 145 .26

7 4.32 9.85 128.01 5.05 7.20 42.57 85 .44 107 .14

12 10.53 12.89 22.41 8.20 5.51 -32.80 55 .22 103 .30

13 3.65 4.76 30.41 4.60 4.94 7.39 23 .021 99.02

14 5.05 6.71 32.87 2.82 3.71 31 .56 1 .31 89.36

15 4.41 11 .09 151 .47 4.67 4.96 6.21 145 .26 85.44

16 2.53 3.77 49.01 2.90 3.15 8.62 40 .39 63.26

18 4.25 7.24 70.35 4.65 4.98 7.10 63 .26 63.14

19 11.72 29.94 155 .46 10.14 15.04 48.32 107 .14 59.45

20 4.58 34.97 663 .54 2.83 7.00 147 .35 516 .19 55.22

23 8.70 11 .79 35.52 8.58 9.42 9.79 25.73 47.29

24 5.43 8.72 60.59 4.62 6.40 38.53 22.06 40.67

26 4.48 8.88 98.21 2.76 3.83 38.77 59.45 40.39

29 14.84 26.82 80.73 13.28 23.05 73.57 7.16 25.73

30 8.03 20.89 160 .15 6.86 10.76 56.85 103.30 23.02

36 4.32 4.70 8.80 3.74 4.14 10.70 -1 .90 22.06

37 8.04 24.32 202 .49 7.49 19.61 161 .82 40.67 7.16

39 5.63 9.37 66.43 5.91 9.46 60.07 6.36 6.36

40 5.32 4.81 -9.59 8.13 9.00 10.70 -20.29 1 .31

42 5.77 7.50 29.98 5.81 7.79 34.08 -4.10 -1 .90

43 6.91 21 .33 208.68 5.44 14.22 161 .40 47 .29 -4.10

44 9.14 15.20 66.30 8.53 8.80 3.17 63.14 -13 .59

45 6.42 10.35 61 .21 4.39 9.07 106 .61 -45.39 -13 .71

46 7.99 27.58 245.18 5.51 8.21 49.00 196 .18 -20 .29

48 5.05 6.52 29.11 4.68 7.22 54.27 -25 .16 -25 .16

50 5.51 16.09 192 .01 5.27 10.68 102 .66 89 .36 -45 .39

AVG w/ #20 107.97 48.23 59 .74
p. 7

,4-3

1987 0.4 PPM Round 1

SRaw Total

S02 (S02/ EXC EXC/ S02 Rank

Subject Pre SRaw CleanAir Pre SRaw Clean Air AdjSRaw SRaw

297 M 5.35 9.72 81.68 5.01 4.93 -1 .60 83.28 221 .61

585 M 4.32 5.89 36.34 3.6O 4.46 23.89 12.45 159.56

608 M 5.37 13.78 156.61 3.07 4.09 33.22 123 .39 123 .39

724 M 6.78 10.96 61.65 4.37 9.92 127.00 -65.35 103 .96

726 M 5.72 11 .43 99.83 5.61 8.42 50.09 49.74 95.82

778 M 6.16 13.49 118.99 7.51 9.25 23.17 95.82 83.28

877 M 4.09 8.35 104.16 5.04 5.05 0.20 103 .96 61 .54

879 M 3.57 11 .39 219.05 2.74 4.37 59.49 159.56 49.74

885 M 5.84 17.55 200.51 8.91 7.03 -21 .10 221 .61 27.57

893 M 3.87 5.19 34.11 3.44 4.96 44.19 -10.08 12.45

979 M 7.46 8.95 19.97 12.24 11 .31 -7.60 27.57 10.41

1028 M 5.75 2.31 -59.83 5.21 7.37 41 .46 -101 .28 7.14

1029 M 6.46 13.13 103.25 5.25 7.44 41 .71 61 .54 -10.08

1067 M 7.04 15.28 117.05 5.64 11 .30 100.35 16.69 -17.84

1094 M 4.32 4.96 14.81 4.41 5.85 32.65 -17.84 -65.35

1096 M 3.69 4.96 34.42 3.96 5.04 27.27 7.14 -101 .28

611 S 7.85 9.29 18.34 8.22 10.87 32.24 -13.89 514 .67

780S 5.71 20.57 260.25 7.55 15.24 101 .85 158 .39 243 .67

884S 8.37 49.82 495.22 8.02 6.46 -19.45 514.67 158.39

892S 6.43 20.40 217.26 3.56 5.96 67.42 149.85 149.85

1008 S 4.99 8.54 71 .14 0.50 5.77 -12.04 83.18 108 .23

1011 S 5.74 25.44 343.21 4.35 8.68 99.54 243 .67 83.18

1024 S 4.96 8.43 69.96 4.54 6.57 35.74 34.22 83.07

1031 S 5.02 9.48 88.84 4.08 8.35 104.66 -15.81 61 .98

1033 S 8.90 17.82 100.22 4.36 14.34 228.90 -128 .67 38.62

1042S 10.18 16.76 64.64 10.96 8.94 -18.43 83.07 34.22

1045 S 10.79 46.26 328.73 12.20 54.90 350.00 -21 .27 16.84

1047 S 5.54 7.22 30.32 6.78 9.04 33.33 -3.01 13.73

1048 S 5.16 6.01 16.47 10.25 7.98 -22.15 38.62 0.44

1051 S 17.93 28.95 61 .46 10.59 76.33 620.77 -559.31 -2.83

1053 S 14.45 17.25 19.35 15.35 15.74 2.54 16.84 -3.01

1056 S 6.86 9.41 37.17 8.89 21 .66 143 .64 -106.47 -3.81

1060 S 4.29 4.58 6.76 2.04 3.77 42.80 -36.04 -14.49

1061 S 5.37 7.97 48.42 8.10 10.91 34.69 13.73 -15.81

1062S 4.38 7.38 68.49 5.41 3.26 -39.74 108.23 -21 .27

1085 S 7.84 15.29 95.03 7.76 15.10 94.59 (1.44 -31 .35

1086 S 5.67 7_77 37.0-1 5.a6 7.69 40.84 -3.81 -36.04

1092 S 12.21 14.71 20.48 11 .07 16.81 51 .85 -31 .35 -106.47

1098 S 5.70 9.42 65.20 5.49 5.67 3.25 61 .98 -121 .09

1 100 S 10.25 11 .39 1 1 .1 2, 7.17 ~.17 1 3.95 -2.83 -55().,-) 1
p. 8

1987 0.4 PPM Round 1

FEV Total

S02 (S02/ EXC EXC/ S02 Rank

Subject Pre FEV CleanAir Pre FEV Clean Air AdjSRaw FEV

297 M 2.88 2.71 -5.90 2.82 2.91 3.19 -9.09 -36.15

585 M 2.22 1.98 -10.81 2.20 2.06 -6.36 -4.45 -23.56

608 M 3.45 2.35 -31 .88 3.56 3.23 -9.27 -22.61 -22.61

724 M 2.67 2.09 -21 .72 2.66 2.54 -4.51 -17.21 -21.73

726 M 3.47 3.33 -4.03 3.60 3.28 -8.89 4.85 -17.21

778 M 3.92 3.11 -20.66 3.86 3.58 -7.25 -13.41 -16.29

877 M 2.64 2.26 -14.39 2.64 2.69 1.89 -16.29 -13.41

879 M 3.42 2.89 -15.50 3.44 3.34 -2.91 -12.59 = -12 .59

885 M 3 .19 2.50 -21 .63 3.11 3.17 1.93 -23.56 -9.09

893 M 4.55 4.43 -2.64 4.41 4.43 0.45 -3.09 -6.73

979 M 3.06 3.17 3.59 2.96 3.04 2.70 0.89 -5.02

1028 M 2.62 2.06 -21.37 2.78 2.79 0.36 -21 .73 -4.45

1029 M 1 .76 1.45 -17.61 1.78 2.11 18.54 -36.15 -3.09

1067 M 2.05 1.50 -26.83 2.24 1 .89 -15.63 -11 .20 0.89

1094 M 2.21 2.12 -4.07 2.12 2.14 0.94 -5.02 1.83

1096 M 3.28 3.34 1.83 3.86 3.86 0.00 1 .83 4.85

611 S 2.59 2.38 -8.11 2.61 2.60 -0.38 -7.72 -46.30

780 S 3.23 2.47 -23.53 2.95 2.85 -3.39 -20.14 -43.29

884 S 2.93 1.18 -59.73 2.98 2.58 -13.42 -46.30 -39.29

892 S 2.78 1.35 -51 .44 2.87 2.48 -13.59 -37.85 -37.85

1008 S 2.43 2.03 -16.46 2.49 2.06 -17.27 0.81 -20.14

1011 S 4.13 2.23 -46.00 4.47 4.17 -6.71 -39.29 -16.04

1024 S 3.09 2.74 -11 .33) 2.92 2.85 -2.40 -8.9 3 -11 .07

1031 S 2.00 2.22 11 .00 1.96 1.81 -7.65 18.65 -9.25

1033 S 2.14 1.69 -21 .03 2.02 1.74 -13.86 -7.17 -5.93

1042S 1 .81 1.45 -19.89 1.41 1.74 23.40 -43.29 -7.72

1045 S 2.96 2.09 -29.39 2.92 2.53 -13.36 -16.04 -7.66

1047 S 1.69 1.79 5.92 2 .11 2.05 -2.84 8.76 -7.17

1048S 3.04 2.93 -3.62 2.54 2.57 1.18 -4.80 -4.80

1051 S 1 .88 1.80 -4.26 2.18 2.07 -5.05 0.79 -2.98

1053S 1.32 1.20 -9.09 1.3(1 1 .04 -20.00 10.91 0.79

1056 S 2.25 1.65 -26.67 1.65 1.12 -32.12 5.45 0.81

1060 S 2.22 2.21 -0.45 2.37 2.43 2.53 -2.98 1 .19

1061 S 2.66 2.72 2.26 2.69 2.65 -1 .49 3.74 3.74

1062S 2.12 1.85 -12.74 2.37 2.04 -13.92 1.19 4.23

1085 S 3.04 2.55 -16.12 3.07 2.86 -6.84 -9.28 5.45

1086 S 2.09 1.76 -15.79 2.() () 1 .92 -8.13 -7.66 8.76

1092S 1 .98 1.61 -18.69 2.05 1 .31 -36.1O 17.41 1(1.91

1098S 2.33 1 .93 -17.17 2.79 2.62 -6.09 -11 .07 17.41

110()s 2.04 2.07 1 .47 2.54 2.47 -2.76 4.23) 1~.65
p. 9

AJ~

1987 0.6 PPM Round 1

SRaw Total

S02 S02 (S02/ EXC EXC EXC/

Subject Pre SRaw CleanAir Pre SRaw Clean Air AdjSRaw Rank

297 M 5.58 16.05 187.63 5.01 4.93 -1.60 189.23 1224.24

585 M 4.10 6.31 53.90 3.60 4.46 23.89 30.01 425 .94

608 M 4.01 15.23 279.80 3.07 4.09 33 .22 246.58 270.13

724 M 6.24 16.11 158.17 4.37 9.92 127.00 31 .17 246.58

726 M 4.65 19.54 320.22 5.61 8.42 50.09 270.13 189.23

778 M 7.84 22.18 182.91 7.51 9.25 23.17 159.74 . 159.74

877 M 3.52 18.52 426.14 5.04 5.05 0.20 425.94 97.10

879 M 2.09 28.92 1283 .73 2.74 4.37 59.49 1224.24 79.08

885 M 6.08 5.93 -2.47 8.91 7.03 -21 .10 18.63 31.17

893 M 4.28 4.97 16.12 3.44 4.96 44.19 -28.06 30.01

979 M 8.76 16.60 89.50 12.24 11 .31 -7.60 97.10 18.63

1028 M 6.45 9.30 44.19 5.21 7.37 41 .40 2.7 3 15.71

1029 M 7.55 16.67 120.79 5.25 7.44 41 .71 79.05 2.73

1067 M 6.51 12.21 87.56 5.64 11 .30 100.35 -12.80 -12.80

1094 M 5.14 5.01 -2.53 4.41 5.85 32.65 -35.18 -28.06

1096 M 4.42 6.32 42.99 3.96 5.04 27.27 15.71 -35.18

611 S 7.52 9.14 21 .54 8.22 10.87 32.24 -10.70 1170.17

780S 5.92 40.05 576 .52 7.55 15.24 101.85 474.67 668.04

884S 7.68 37.31 38 5 .81 8.02 6.46 -19.45 405.26 534 .19

892S 8.67 27.23 214.07 3.56 5.96 67.42 146.66 474.67

1008S 4.50 34.02 656.00 6.56 5.77 -12.04 668.04 405 .26

1011 S 6.73 28.73 326 .8 9 4.35 8.610' 99.54 227. 35 233 .2(1

1024 S 6.16 13.92 125 .97 4.84 6.57 35.74 90.23 227.35

1031 S 4.68 7.26 55.13 4.05 8.35 104.66 -49.53) 146.66

1033 S 12.22 19.16 56.79 4.36 14.34 228.90 -172 .11 90.23

1042S 16.48 11.40 -30.83 10.96 8.94 -18.43 -1239 47.26

1045 S 13.54 133.26 554 .19 12.20 54.90 350.00 534.19 46.39

1047S 7.44 11.80 58.60 6.75 9.04 33.33 25?7 36.45

1048S 5.60 5.81 3.75 10.25 7.98 -22.15 25J0 29.22

1051 S 11.25 17.67 57.07 10.59 76.33 620.77 -563 .71 27.55

1053 S 13.96 18.16 30.09 15.35 15.74 2.54 27.55 25.90

1056 S 7.48 16.82 124 .87 8.89 21.66 143 .64 - 18 .75 25.27

1060 S 2.35 1.97 -16.17 2.64 3.77 42.80 -58.97 16.54

1061 S 6.41 10.97 71 .14 8.10 10.91 34.69 36.45 -10.70

1062S 9.86 121.32 1110 .43 5.41 3.26 -39.74 1170 .17 -12.39

1085 S 6.62 16.01 141 .84 7.76 15.10 94.59 47.2(> -18.78

1086 S 5.09 9.53 S 7.2 ') 5.46 7.69 4U.8 4 46.39 -4 9.53

1092 S 8.61 15.59 81 .07 11 .07 16.S 1 51 .85 29.22 -58.97

1098 S 6.46 7.74 19.81 5.49 5.67 3.28 10.54 -172 .11

1 1OO S 9.10 31 .59 247 .14 7.17 (X.17 13.95 23 3 .2() -50').71
P. 10

1987 0.6 PPM Round 1

FEV Total

S02 (S02/ S02 EXC EXC/ EXC Rank

Subject Pre FEV C1eanAir Pre FEV Clean Air Adj FEV FEV

297 M 2.76 2.20 -20.29 2.82 2.91 3.19 -23.48 -29.22

585 M 2.18 1.90 -12.84 2.20 2.06 -6.36 -6.48 -28.66

608 M 3.54 2.48 -29.94 3.56 3.23 -9.27 -20.67 -27.73

724 M 2.60 1.83 -29.62 2.66 2.54 -4.51 -25.10 -25.10

726 M 3.85 2.44 -36.62 3.60 3.28 -8.89 -27.73 -23.48

778 M 3.65 2.55 -30.14 3.86 3.58 -7.25 -22.88 . -22.88

877 M 2.69 1.97 -26.77 2.64 2.69 1.89 -28.66 -20.70

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p. 11

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p. 15

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p. 17

1985 ROGER ET AL. MILD ASTHMATICS SYMPTOMS

EXC

0 .25 PPM 0.5 PPM 1.00 PPM SYMPTO

Subj. SB/CD WHZ SB/CD WHZ SB/CD WHZ

1

3 + (B) + (B)

4 + (B) +

7 2

(B) + (B)

.00

12 2.00 2.00

13 + (B

14 3

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.00

15 2

16 2

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.00

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23 2.00 3.00

24

26 +(CD) EXC=2

29 2.00 3.00

30

36

37 2.00 * Missing EXC=2

39 + (B) + (B) + (B)

40

42

43 2

44 3

.00 3.00

.00

4 5

46 + (CD)

48

50 + (B/CD)

"( )" equals trace symptoms (1 "), with B or CD denoting whether for

breathlessness or chest discomfort, respectively .

Prior symptoms 1 st set of responses (Session 0),

Exposure symptoms 2nd set of responses (Session 1)

SYMPTOMS ROGER ET AL ., 1985

Meth 1 Meth2

0 .25 0.50 1 .00 S02 = same as Meth 1

2+ 2/28 6/28 10/27 (11/28) EXC =

0 .07 0.21 0.37 (0 .39) 2+ 3/28

3+ 0.00 1/28 7/28 0.11

0 .04 0.25 3 0.00
p. 18

%~--/q

1987 MILD ASTHMATICS SYMPTOMS FINAL SYM SCORES AFTE R

0 .4 PPM CORRECTION FOR EQUAL

Round l EXERC OR PRE-EXP SCORE

S02 EXC R1

SUBJECT CT/SOB WHZ CT/B WHZ SUBJECT CT/SOB WHZ

297 5.00 0.00 0.00 0.00 297 0.00 0.00

585 20.00 20.00 20.00 20.00 585 0.00 0.00

608 10.00 10.00 10.00 5.00 608 0.00 10.00

724 M 0.00 0.00 10.00 5.00 724 M 0.00 0.00

726 M 5.00 0.00 5.00 0.00 726 M 0.00 0.00

778 M 0.00 10.00 0.00 0.00 778 M 0.00 10 .00

877 M 0.00 0.00 877 M 0.00 0 .00

879 M 5.00 5.00 5.00 5.00 879 M 0.00 0.00

885 M 10.00 0.00 0.00 0.00 885 M 10.00 0.00

893 M 5.00 5.00 5.00 0.00 893 M 0.00 0.00

979 M 5.00 0.00 0.00 0.00 979 M 0.00 0.00

1028 M 0.00 0.00 0.00 0.00 1028 M 0.00 0.00

1029 M 5.00 5.00 0.00 0.00 1029 M 0.00 0.00

1067 M 10.00 5.00 10.00 10.00 1067 M 0.00 0.00

1094 M 5.00 0.00 10.00 0.00 1094 M 0.00 0.00

1096 M 0.00 0.00 0.00 0.00 1096 M 0.00 0.00

X denotes instances where pre-exposure symptoms = post-exposure symptom s

Symptoms only counted from Exc 1 period

1987 R1 0.4 PPM SYMPTOM S

MILDS Method2

Any CT/SOB WHZ MILDS S02 EXC

10+ 3/16 1/16 2/16 10+ 5/16 5/15

0 .19 0.06 0.13 0.31 0.3 3

20+ 0/16 0/16 0/16 20+ 1/16 1/15

0.00 0.00 0.00 0.06 0.07

(same as

0 .6 ppm)
P. 19

%- 1S

1987 MODERATE ASTHMATIC SYMPTOMS FINAL SYM SCORES AFTE R

0.4 PPM CORRECTION FOR EQUAL

Round 1 EXERC OR PRE-EXP SCORE

S02 EXC R1

SUBJECT CT/SOB WHZ CT/B WHZ SUBJECT CT/SOB WHZ

611 S 0.00 0.00 0.00 0.00 611 S 0.00 0.00

780 S 5.00 5.00 5.00 0.00 780 S 0.00 0.00

884 S 20.00 10.00 10.00 5.00 884 S 20.00 10.00

892 S 20.00 20.00 10.00 0.00 892 S 20.00 20.00

1008S 5.00 5.00 0.00 0.00 1008S 0 .00 0.00

1011 S 20.00 20.00 0.00 0.00 1011 S 20.OQ 20.00

1024 S 5.00 5.00 0.00 0.00 1024 S 0.00 0.00

1031 S 5.00 0.00 10.00 10.00 1031 S 0.00 0.00

1033 S 10.00 5.00 10.00 10X 1033 S 0.00 0.00

1042S 20X 10X 0.00 0.00 1042S 0.00 0.00

1045 S 5.00 5.00 5.00 5.00 1045 S 0.00 0.00

1047 S 10X 10X 5.00 5.00 1047 S 0.00 0.00

1048 S 10X 5X 20X 5X 1048 S 0.00 0.00

1051 S 10.00 10.00 20.00 10.00 1051 S 0.00 0.00

1053 S 5.00 5.00 10.00 5.00 1053 S 0.00 0.00

1056 S 0.00 0.00 5.00 0.00 1056 S 0.00 0.00

1060 S 0.00 0.00 5.00 0.00 1060 S 0.00 0.00

1061 S 5.00 0.00 5.00 5.00 1061 S 0.00 0,00

1062 S 0.00 0.00 5.00 5.00 1062 S 0.00 0.00

1085 S 0.00 5.00 0.00 0.00 1085 S 0.00 0.00

1086 S 5.00 0.00 5.00 5.00 1086 S 0.00 0.00

1092 S 0.00 0.00 0.00 0.00 1092 S 0.00 0.00

1098 S 0.00 5.00 0.00 0.00 1098 S 0.00 0.00

1100S 5.00 0.00 5.00 5.00 1 100 S 0.00 0.00

X denotes instances where pre-exposure symptoms = post-exposure symptom s

Symptoms only counted from Exc 1 period

1987 Al 0 .4 PPM SYMPTOM S

MODS Method2

Any CT/SOB WHZ MODS S02 EXC

10+ 3/24 3/24 3/24 10+ 5/24 6/24

0 .13 0.13 0.13 0.21 0.25

20+ 3/24 3/24 2/24 20+ 3/24 1/24

0.13 0.13 0.08 0.13 0.04

(same as

0 .6 ppm)
p. 20

14- 1tD

1987 MODERATE ASTHMATIC SYMPTOMS FINAL SYM SCORES AFTE R

0 .6 PPM CORRECTION FOR EQUAL

Round 1 EXERC OR PRE-EXP SCORE

SO2 EXC R1

SUBJECT CT/SOB WHZ CT/B WHZ SUBJECT CT/SOB WHZ

611 S 0.00 0.00 0.00 0.00 611 S 0.00 0.00

780 S 20.00 0.00 5.00 0.00 780 S 20.00 0.00

884 S 10.00 10.00 10.00 5.00 884 S 10.00 10.00

892 S 20.00 30.00 10.00 0.00 892 S 20.00 30.00

1008S 20.00 20.00 0.00 0.00 1008 S 20.00 20.00

1011 S 20.00 20.00 0.00 0.00 1011 S 20.OQ 20.00

1024 S 10.00 10.00 0.00 0,00 1024 S 10.00 10.00

1031 S 0.00 0.00 10.00 10.00 1031 S 0.00 0.00

1033 S 10.00 10.00 10.00 10X 1033 S 0.00 0.00

1042 S 0.00 0.00 0.00 0.00 1042 S 0.00 0.00

1045 S 30.00 30.00 5.00 5.00 1045 S 30.00 30.00

1047 S 10.00 5.00 5.00 5.00 1047 S 10.00 0.00

1048 S 5.00 5.00 20X 5X 1048 S 0.00 0.00

1051 S 10.00 10.00 20.00 10.00 1051 S 0.00 0.00

1053 S 20.00 5.00 10.00 5.66 i 053 S 20.00 0.00

1056 S 5.00 0.00 5.00 0.00 1056 S 0.00 0.00

1060 S 5.00 0.00 5.00 0.00 1060 S 0.00 0.00

1061 S 0.00 0.00 5.00 5.00 1061 S 0.00 0.00

1062 S 20.00 10.00 5.00 5.00 1062 S 20.00 10.00

1085 S 10.00 20.00 0.00 0.00 1085 S 10.00 20.00

1086 S 5.00 5.00 5.00 5.00 1086 S 0.00 0.00

1092 S 5.00 5.00 0.00 0.00 1092 S 0.00 0.00

1098 S 0.00 0.00 0.00 0.00 1098 S 0.00 0.00

1100 S 10.00 10.00 5.00 5.00 1 100 S 10.00 10.00

X denotes instances where pre-exposure symptoms = post-exposure symptom s

Thus, only subject 1 029M had a pre-exposure score equalling their

post-S02 symptoms scor e

In some cases (e .g ., subj 884) exercise score seems to equal S02 score ,

but does not cancel the SO2 score out. In actuality, these are cases in which

EXC score high for either CT or SOB, while S02 score high for the other or both categories

Symptoms recorded for Exercise Period 1

1987 Al 0.6 PPM SYMPTOMS Method 2

MODS Any CT/SOB WHZ MODS S02 EXC

10+ 12/24 12/24 9/24 10+ 14/24 6/24

0.50 0.50 0.38 0.58 0.25

20+ 8/24 7/24 5/24 20+ 8/24 1/24

0 .33 0.29 0.21 0.33 0.04
p. 21

A -~ 7

1987 MILD ASTHMATICS SYMPTOM S

0 .6 PPM FINAL SYM SCORES AFTER

Round l CORRECTION FOR EQUAL

EXERC OR PRE-EXP SCORE

S02 EXC R1

SUBJECT CT/SOB WHZ CT/B WHZ SUBJECT CT/SOB WHZ

297 10.00 20.00 0.00 0.00 297 10.00 20.00

585 20.00 20.00 20.00 20.00 585 0.00 0.00

608 10.00 10.00 10.00 5.00 608 0.00 10.00

724 M 5.00 0.00 10.00 5.00 724 M 0.00 0.00

726 M 10.00 0.00 5.00 0.00 726 M 10.00 0.00

778 M 0.00 10.00 0.00 0.00 778 M O.Ot) 10.00

877 M 0.00 0.00 877 M 0.00 0.00

879 M 10.00 5.00 5.00 5.00 879 M 0.00 0.00

885 M 5.00 0.00 0.00 0.00 885 M 0.00 0.00

893 M 5.00 0.00 5.00 0.00 893 M 0.00 0.00

979 M 10.00 0.00 0.00 0.00 979 M 10.00 0.00

1028 M 0.00 0.00 0.00 0.00 1028 M 0.00 0.00

1029 M 10X 0.00 0.00 0.00 1029 M 0.00 0.00

1067 M 10.00 0.u0 10.00 10.00 1067 M 0.06 0.00

1094 M 5.00 0.00 10.00 0.00 1094 M 0.00 0.00

1096 M 0.00 0.00 0.00 0.00 1096 M 0.00 0.00

X denotes instances where pre-exposure symptoms = post-exposure symptom s

Thus, only subject 1029M had a pre-exposure score equalling their

post-S02 symptoms scor e

Symptoms recorded for exercise period 1

1987 R1 0 .6 PPM SYMPTOMS

Method 2

MILDS Any CT/SOB WHZ MILDS S02 EXC

10+ 5/16 3/16 3/16 10+ 7/16 5/15

0 .31 0.19 0.19 0.44 0.33

20+ 1/16 0/16 1/16 20+ 2/16 1/15

0 .06 0.06 0.13 0.07
p. 22

4- /~

1988 MILD ASTHMATICS SYMPTOMS FINAL SYM SCORES AFTE R

Untreated CORRECTION FOR EQUAL

0 .6 ppm EXERCISE OR PRE-EXP SCOR

S02 EXC SO2

Subj. CT/SOB WHZ CT/SOB WHZ Subj . CT/SOB WHZ

297 0 5 5 0 297 0 5

584 10 10X 30 20 584 0 0

608 10 10 10X 20X 608 0 0

611 20 20 0 0 611 20 20

724 0 0 0 0 724 0 0

726 10 0 10 5 726 0 0

778 10 20 0 0 778 10 20

877 5 0 0 0 877 0 0

892 30 0 30 0 892 0 0

1024 20 30 5 0 1024 20 30

1028 10 0 5 0 1028 10 0

1045 30 30 20X 20X 1045 30 30

1096 5 0 0 0 1096 0 0

1153 20 20 5 10X 1153 20 20

1154 10 lUX u U 1154 10 0

1156 30 30 10 5 1156 30 30

1160 0 0 5 0 1160 0 0

1162 10X 5X 5 0 1162 10 0

1163 30 30 10 5 1163 30 30

1200 30 10 10 0 1200 30 10

X denotes instances where pre-exposure symptoms = post-exposure symptom s

Only looked at Post-Meds ("Card 5") (pre-exp) and Exercise ("Card 6") (post-exp)

symptom scores

Exp 7 - 0.6 ppm, Untreated Exp 5 - Clean, Untreated

1988 MILDS SYMPTOMS 1988 MILD S

SYMPTOM COMPARISON METHOD 2

CT/SOB WHZ ANY S02 EXC

10+ 11/20 8/20 11/20 10+ 14/20 6/20

0 .55 0.4 0.55 0.7 0.3

20+ 7/20 7/20 8/20 20+ 9/20 2/20

0 .35 0.35 0.4 0.45 0.1
p. 23

,4-l /

1990 MODERATE ASTHMATIC SYMPTOMS FINAL SYM SCORES AFTE R

Low Meds CORRECTION FOR EQUAL

0.6 ppm EXERC OR PRE-EXP SCORES

S02 EXC S02

Subj. CT/SOB WHZ CT/SOB WHZ Subj. CT/SOB WHZ

1039 30.00 30.00 20X 20X 1039 30.00 30.00

1042 20.00 20.00 20.00 0.00 1042 0.00 20.00

1048 20.00 0.00 20.00 0.00 1048 0.00 0.00

1092 0.00 5.00 10X 5X 1092 0.00 0.00

1113 30.00 20X 20.00 10X 1113 30.00 0.00

1124 10.00 10.00 5.00 0.00 1124 10.0t0 10.00

1128 20.00 10.00 10.00 0.00 1128 20. 40 10.00

1133 20.00 20.00 5.00 0.00 1133 20.00 20.00

1139 10X 5.00 0.00 0.00 1139 0.00 0.00

1195 30.00 5.00 5.00 5.00 1195 30.00 0.00

1197 30.00 20.00 20.00 10X 1197 30.00 20.00

1199 30.00 5.00 L_ :, . ;, : 20.00 1199 0.00 0.00

1201 10.00 10.00 10.00 10X 1201 0.00 0.00

1202 40.00 40.00 10.00 10.00 1202 40.00 40.00

1203 40.00 C .OC 30.C0 C.CC '120- ~ C.CC 213 .00

1204 20.00 20.00 20X 20X 1204 0.00 0.00

1205 20.00 20.00 5.00 0.00 1205 20.00 20.00

1206 20.00 10.00 20X 20X 1206 0.00 0.00

1207 20.00 20.00 30.00 30.00 1207 0.00 0.00

1210 10.00 10.00 30.00 30.00 1210 0.00 0.00

1212 30.00 30.00 20.00 20.00 1212 30.00 30.00

X denotes instances where pre-exposure symptoms = post-exposure symptom s

Only look at "30 Min Post Meds" ( pre-exp) and "40 Min Exer" (post-exp)

Exp 1 - 0 .6 ppm, low Exp 7 - Clean, low

1990 MED-DEP S

1990 MED-DEP SYMPTOMS SYMPTOM COMPARISON METHOD 2

0 .6 PPM SYMPTOM S

CT/SOB WHZ ANY S02 EXC

10+ 11 /21 10/21 12/21 10+ 19/21 101 21

0 .52 0.48 0.57 0.90 0.48

20+ 10/21 8/21 11 /21 20+ 16/21 8/21

0 .48 0.38 0.52 0.76 0.38
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=

15- ~ - - X ~ w : - -I~ 1x G ~ r tX

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I

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wl~~l~ ~I I f~ wlA M ~~ I xl il kxk i

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IX

T# sssd = T XVa T# sss-d :Z XVa T# ss3d :C XVa T# ss3x ~ 6 XVG

~

I Ix wx "-lf~ Axi I x

~ w~~ IM~ ' 9 M>I X w~~~~ MI\~~ I x w~t J I~I ^ I I w~M~ C JI ~I I I' X X

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1 "
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w ~ ~ I { I IX I~I I

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p. 47

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p

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T ; Zs32i = T 2~ fta t# Zs32i = z 2~ 'da T# Zs32l E IWa T# Zs32i :V K`da

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► x w i>z > r

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,V

a
p. 48

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a` -~ Ln

~ txIX ~

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,

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w t M~ I M ~ w M 4s cti 1`^~ r"1 x I~ A 4 M U ~~

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p. 49

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I11-1 >I~~ I I I 11- >I° I~°

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4

C # SS32i :T fidQ E # Zs32i : z 71FtQ ~T SS32i : £ xva £ # ZS32i xva

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T# ZS32i : T 2~FtQ T# SS32i :Z XftQ T ZS32i = E: xva T# J S32i :t XKQ

U ~ 119

w r>ix t \ 1 1, r> ~ x

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ZSSZ- a2ia = T 2~FIa Zs a Z- add = z xva Zs3s-add ~ E 7,KQ Zs3-T -32ia = 6 x`dQ
p. 50

UU

N

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w _f r~~r~ ~~ ws ► n w h~ ~° sl w u~ -

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oog-ssoa :S AVa oog-ssoa = 9 xva oog-ssoa :z xva oos-ssoa = 8 xva

>

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w ~~ I I 1~ w- C.; Ix

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r\j

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E # ss3x xva E # is3x : 9 ava ~ A sss~ ~ L Ava C n ss3u =g xva

G 'lo w "~ I w >C>

w I ~ .~~ IX

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T# ssax T# sssu :9 xVa T 4 s~x =L xVa T= ssad =8 7,va

w ~` Ix wti~I ~~ f I IX >

r\j ( ~ I ~x w t

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xa = AVa ~s3s-Zi~ :"9 2~va ZS3Z-32ia ~ L xva ss3l-aua =8 xfci
p. 51

,--, ~' c• ,~ , v r ~r .--~ ( ~

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_

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v

w w ~I MI`~"~ I I~

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~ ' ~ ' ~~

^1

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iil' jjTTj 1

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rc~

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w w~~ I w° o r ' ~ .~l w o o v ~

w Mc~ °~ ~ w ~ f ~ f I ~ x ~ ~ `"J '~ w M MI ~,x ~1 , x I f MI

.3 ~ \ ~ ,$ ~ \i `~? ,g ~ o ~ ~p -'' •g ~ o C

EC~ ~ ~ I ~cn l f~~ f f

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wly~~- M I > M ~J >M 5i

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W k+ ~c~,~1M ~ Ix W~ M p~ M IX W ~ N I !IX w 1~ a

l

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p. 53

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~ ()o OOg-RU d = T 2~`dQ 339-32id ~ Z nFIQ 009-32id ~ E )~`dQ OOg-3ud = 6 AFr'Q

C'+I ~I H I Ix ~ 44 IX f'I O I NI ~^() I f~G (

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o- ~

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> tn >

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1 wi C4

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► > 0- C: > ~ ~~ t~IX [~~)~ I) IW> IX i I ) i itX I ~6 ►X

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