1 Subject: FW: for NOX docket: FW: question re: 2011 EHP Spira-Cohen paper Attachments: thesis results for NO2 and SO2.docx

From: Ariel Spira-Cohen [ mailto:arielsc@gmail.com ] Sent: Thursday, July 25, 2013 9:54 PM To: Patel, Molini Cc: George D. Thurston, Sc.D. Subject: Re: question re: 2011 EHP Spira-Cohen paper



### Please see the attached. Let me know if you need more!

Ariel

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On Thu, Jul 25, 2013 at 2:59 PM, Patel, Molini < Patel.Molini@epa.gov > wrote: Thanks George and Ariel! My email to you this morni ng got stuck in my outbox. If you could point me to the table in your dissertation, that woul d be great! And providing the NO2 and SO2 results is an excellent suggestion! We may need them shortly.

Molini M. Patel, PhD, MPH Epidemiologist U.S. Environmental Protection Agency National Center for Environmental Assessment Mailcode: B243-01 Research Triangle Park, NC 27711 Phone: 919.541.1492 , Fax: 919.541.1818 , Email: patel.molini@epa.gov

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### -----Original Message----- From: George D. Thurston, Sc.D. [mailto: george.thurston@nyu.edu ] Sent: Wednesday, July 24, 2013 6:01 PM To: Patel, Molini Cc: Ariel Spira-Cohen Subject: Re: question re: 2011 EHP Spira-Cohen paper

Molini, Thanks for your interest in including our study. Th e person who would have this information is the first author, Ariel Spira-Cohen. I have CC'd her on this email, so she can provide you with those values for NO2. One suggestion: there were also significant results for SO2, which you may need in the near future, so Ariel should also send you the same info for SO2 at the same time. Make sense? George

Dr. George D. Thurston Professor NYU School of Medicine Nelson Institute of Environmental Medicine2 

### 57 Old Forge Rd. Tuxedo, NY 10987-5007 USA PH: 845-731-3564 Faculty Web Page: http://www.med.nyu.edu/research/gdt1.html

.................................................................................................... Hi Dr. Thurston, We're moving closer to the release of the first draft NOx ISA and hope you can provide us with some additional information from your 2011 EHP paper, "Personal Expos ures to Traffic-Relate d Air Pollution and Acute Respiratory Health among Bronx Sc hoolchildren with Asthma."

Could you provide the quantitative data (RR and 95% CI) for results presen ted in Figure 1, specifically the school-site NO2 results for cough, wheeze, shortness of br eath, and total respiratory symptoms for lag 0, 1, and 2-day average. Thanks! Molini

> Molini M. Patel, PhD, MPH Epidemiologist U.S. Environmental Protection Agency National Center for Environmental Assessment Mailcode: B243-01 Research Triangle Park, NC 27711 Phone: 919.541.1492, Fax: 919.541.1818, Email: patel.molini@epa.govEHP article Figure 1:

Cough Short Breath Wheeze Total Symptoms Same day NO2 1.15 (0.87, 1.51) 1.11 (0.73, 1.68) 1.20 (0.75, 1.9) 1.10 (0.84, 1.45) Lag 1 day NO2 1.02 (0.77, 1.35) 0.74 ( 0.48, 1.14) 0.79 (0.5, 1.27) 0.92 (0.7, 1.21) 2day avg NO2 1.18 (0.79, 1.74) 0.89 (0.5, 1.59) 1.02 (0.54, 1.94) 1.05 (0.71, 1.55)

SO2 results: The SO2 analysis was a little different than the analysis I published in EHP and was part of a sensitivity analysis . I use d peak morning concentrations for SO2 and NO2 fr om the monitor at the school

site

. (T he results are descri bed on pages 97

- 98 of my thesis and Tables E.3 and E.4)

Cough Short Breath Wheeze Morning max SO2 1.42 (1.15, 1.76) 1.32 (0.93, 1.88) 1.56 (1.11, 2.19) Morning max NO2 1.29 (1.03, 1.61) 1.10 (0.78, 1.56) 1.25 (0.87, 1.8)

Lung Function results with SO2 (using afternoon lung function metrics with morning max concentrations) were not statistical l y significant. However, lung function metrics showed a predominantly negative relationship. FEV/FVC fraction had very small coefficient but p value was = .05. Do you want these numbers as well? They are shown in Table E.3 of my thesis.