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                            Funding & Awards
 Development and Evaluation of a Whole Genome Amplification Method for Accurate Multiplex STR Genotyping of Compromised Forensic Casework Samples
Award Information
Awardee
              Virginia Commonwealth University
Award #
              2005-DA-BX-K002
Funding Category
              Competitive
Location
                    Richmond, VA
Congressional District
              4
Status
              Closed
Funding First Awarded
              2005
Total funding (to date)
              $225,616
Original Solicitation
              Forensic DNA Research & Development Full Application
Description of original award (Fiscal Year 2005, $225,616)
Whole genome amplification (WGA) techniques have been used in a number of molecular diagnostic areas, including embryonics, cancer biology, histopathology, and in a variety of studies on molecular diseases. WGA allows low copy number DNA samples to be preamplified such that high quality, high yield DNA samples can be available for a variety of downstream amplification techniques and analyses (such as STR analysis). This project will evaluate whole genome amplification for forensic applications. As part of these studies, this project will evaluate the ability of all WGA products to generate a correct profile with distinct and balanced peaks at all multiplexed STR loci with minimal stochastic variation.  Additionally, after optimization experiments have been completed, testing experiments will be performed using non-probative evidence from forensic cases.



ca/ncf



  
Grant-Funded Publications
        
                      Multiplex Short Tandem Repeat Amplification of Low Template DNA Samples with the Addition of Proofreading Enzymes
                  dcDegenerate Oligonucleotide Primed-PCR for Multilocus, Genome-wide Analysis From Limited Quantities of DNA
                  Development and Evaluation of a Whole Genome Amplification Method for Accurate Multiplex STR Genotyping of Compromised Forensic Casework Samples

  
Date Created: September 18, 2005
    
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