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                            Funding & Awards
 Analysis of DNA Forensic Markers Using High Throughput Mass Spectrometry
Award Information
Awardee
              Isis Pharmaceuticals, Inc.
Award #
              2006-DN-BX-K011
Funding Category
              Competitive
Location
                    Carlsbad, CA
Congressional District
              49
Status
              Closed
Funding First Awarded
              2006
Total funding (to date)
              $451,382
Original Solicitation
              NIJ FY06 Forensic DNA Research and Development Solicitation: Invited Full Applications
Description of original award (Fiscal Year 2006, $451,382)
In this project, the researcher will build upon existing collaborations with the DNA Forensics Division of the FBI and the Armed Forces Institute of Pathology DNA Identification Laboratory for the purposes of developing a next generation DNA forensics platform based on high throughput electrospray ionization mass spectrometry (ESI-MS). The approach is based on using ESI-MS to "weigh" DNA forensic markers (as opposed to separating them by size) with enough accuracy to yield an unambiguous base composition (i.e. the number of As, Gs, Cs, and Ts) which in turn can be used to derive a DNA profile for an individual. This project will further develop ESI-MS for mtDNA and STRs as well as perform developmental validation studies (e.g., sensitivity, specificity, mixture studies) and implement a prototype semi-automated bench-top platform.
ca/ncf



  
Grant-Funded Publications
        
                      Automated Analysis of Sequence Polymorphism in STR Alleles by PCR and Direct Electrospray Ionization Mass Spectrometry
                  Base Composition Profiling of Human Mitochondrial DNA Using Polymerase Chain Reaction and Direct Automated Electrospray Ionization Mass Spectrometry
                  Analysis of DNA Forensic Markers Using High Throughput Mass Spectrometry

  
Date Created: September 10, 2006
    
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