## UNITED STATES ENVIRONMENTAL PROTECTION AGENCY WASHINGTON, 

## D.C . 20460



## MEMORANDUM DATE : 05

-NOV

-2015 OFFI CE OF C HEMICAL SAFETY AND POLLU TION PRE VENTION



## SUBJECT: Saflufenacil. Acute and Chronic Aggregate Dietary (Food and Drinking Water) Exposure and Ri sk Assessment for To lerances for Residues in/on Pomegranate. 

## PC Code: 118203 

## DP Barcode: D426932 

## Decision No.: 493885 

## Registration No. : 7969-276 

## Petition No.: 4F8305 

## Regulatory Action: Sec. 3 Registration 

## Risk Assessment Type: Dietary 

## CaseNo.: NA 

## TXRNo.: NA 

## CAS No.: 372137

- 35

-4 

## MRIDNo.: NA 40 

## CFR: §180.649 

## FROM: George F. Kramer, Ph.D., Senior Chemist

# ~**~'2»~** :a 

## Risk Assessment Branch 1**(RA~ )/Hea** **th** 

## Effects Division (HED ; 7509P) 

# r) I I I} 

## THROUGH: William Cutchin,

# Chemist**::ZA~ l~~**  Kristin Rury, Biologist 

# ¥..-**~** Dietary Exposure Science

## Advi~rrCouncil (DESAC) HED (7509P) and Charles W. Smith 111 , Branch Chief

# ~ RABI , HED (7509P) 

## T O: George F . Kramer, Ph.D. , Risk Assessor RAB 1/HED (7509P) and Kathryn Montague/Bethany Benbow, PM Team 23 Registration Division (RD) (7505P) 

## Exec utive S ummary Acute and chronic dietary-exposure and risk assessments were conducted using the Dietary Exposure Evaluation Model - Food Consumption Intake Database (DEEM-FCID , ver. 3 .1 6) which incorporates consun1 ption data from United States Department of Agriculture (US D A) National Health and Nutrition Examination Survey , What We Eat in America, (NHANES/WWEIA; 2003-2008). These analyses were performed to support tolerance petitions for residues in/on pomegranate. This memorandum was reviewed by two peer reviewers of the DESAC, per DESAC SOP 2012.1. Page I of20

### Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

## Acute Dietary (Food and Drinking Water) Exposure Results and Characterization The unrefined acute analysis assumed I00% crop treated (CT), DEEM 7.8 1 default concentration factors, and to lerance-level residues for all commodities [except for cottonseed; sunflower subgroup 20B; soybean, seed ; vegetab le, legume, subgroup 6C , pea and bean (except soybean); and rapeseed subgroup 20A

- see Section II for mor e details]. The drinking water estimate from the proposed U.S. use was incorporated directly into the dieta ry assessment using the peak concentration for surface water generated by Ti er l Rice modeling . The acute dietary ri sk estimates (food + water) at the 95th percentile are < 1% of the acute population-adjusted dose (aPAD) for the general U.S. population and < 1% of the aPAD for the most highly exposed population subgroup (all infants (<I -year old)). and are thus below HED 's level of concern (< 100% aPAD). Chronic Dietary (Fo od and Drinking Water) Exposure Results and Characterization The unrefined chronic analysis assumed 100% CT, DEEM 7 . 81 default concentration factors , and to lerance-level residues for all commodities [except for cottonseed ; sunflower subgroup 20B; soybean , seed; vegetab le, legume, subgroup 6C, pea and bean (except soybean); and rapeseed subgroup 20A

- see Section II for more detai ls]. The drinking water estimate from the proposed U .S . use was incorporated directly into the dietary assessment using the average concentration for surface water generated by Tier I Rice modeling. The chronic dietary risk estima te s (food 

## + water) are 9.2% of the chronic population

-adjusted dose (cPAD) for the general U . S. population and 20% of the cPAD for the most highly expo sed population subgroup (a

JI infants (< I-year o ld)) and are thus below HE D 's level ofconcern (< 100% c PAD). Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization Saflufenacil is classifi ed as " not likely carci nogenic to humans. " Therefore, cancer risk is not a concern for this chemical. I. 

## Introduction Di etary risk assessment incorpora tes both exposure and toxicity of a given pesticide. For acute and chronic assessments, the ri sk is expressed as a percentage of a maximum acceptable dose (i.e. , the dose which HED has concluded will resu lt in no unreasonable adverse health effects). This dose is referred to as the PAD. The PAD is equivalent to point ofdeparture (POD , noobserved adverse-effect level (NOA.EL), lowest-observed adverse-effect level ( LOA.EL), i.e. ) divided by the required uncertainty or safety facto rs. For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk exceeds 100% ofthe PAD. References which discuss the acute and chronic ri sk assessments in more detail are avail ab le on the EPNpesticides web site: "Available Information on Assessing Exposure from Pesticides, A User's Guide," 2 1-JUN-2000; or see SOP 99.6 (20

-AUG-19 99) . The most recent dietary exposure risk assessment for saflufenacil was conducted by G. Kramer (Memo, 24

-JUN-2014 , 0 418585).

Page 2 of20

### Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

## II. Residue Information Saflufenacil Proposed and Registered Uses: Saflufenacil is currently registered for use on alfalfa; legume vegetab les (Crop Group 06); the foliage oflegume vegetables (Crop Group 07); citrus fruit (Crop Group 1 O); 

## pome fruit (Crop Group 11); sto ne fruit (Crop Group 12); tree nuts (Crop Group 14) ; cereal grain s (Crop Group 15); the forage, fodder, and straw of cereal grains (Crop Group 16); cotton; grass (Crop Group 17); olives; and sunflower. BASF has submitted a proposal for a new use ofTreevix®Powered by Kixor®Herbicide (EPA Reg. No. 7969-276) to the base ofpomegranate trees. Residues of Concern: T he previously submitted metabolism data for com, soybean, and tomato were adequate to elucidate the nature ofthe residue in plants resulting from pre-plant/preemergence application. The HED Residues of Concern Knowledgebase Subcommittee (ROCKS) detennined that residues ofconcern for the tolerance expression and risk assessment consist of safl ufenac il, M800Hl 1, and M800H35 (Memo, B. Daiss , 06-JAN-2009; D359645). This conclusion was translated to perennial crops (i.e. , tree fruits and tree nuts) where saflufenacil application is directed to the weeds on the orchard floor (Memo, G. Kramer, 22

- JUL-2009; D 349938). As the proposed use on pomegranate is also directed to weeds at the base ofthe plants , HED concludes that the residues of concern for the tol erance expression and risk assessment a lso consist of saflufenacil, M800Hl 1, and M800H35 for this crop . The nature ofthe residue in livestock is adequately understood based on acceptable metabolism studies conducted on lactating goats and laying hens. There are no li vestock feedstuffs associated with the proposed use; therefore, no changes in the existing tolerances for livestock commodities are needed. Table 1. Summary of Metabolites and Deg ra d ates to be I ncluded in the Risk Assessment. Matrix Residues Included in Risk Residues Included in Assessment To lerance Expression Primary Crops (prep lant Satlufenac il 

### + M800H 11 , Satlufenacil 

### + M800H I I, application)* M800H35 M800H35 Plants Primary Crops (fo liar Satlufenacil 

### + M800 H 11 , application) M800H02 , M800H35 Rotational Crops Satlufenaci l 

### + M800H 11 , M800H35 Livestock Ruminants Poultry Saflufenacil Saflufenac il Saflufenac il 

### + M800HO I , Drinking Water M800H02, M800H07 , M800H08 , Not Applicable M800H 1 5, M800H22 , Product 8 * Plus post-emergence fo li ar application to cereal grains and grasses and to weeds in frui t/nut orchards/groves. 

## Established Tolerances (40 CFR § 180.649): Permanent tolerances are establi shed for " satlufenacil, including its metabolites and degradates , in or on the commodities in the table below. Compliance with the tolerance levels specified below is to be determined by measuring only the sum of saflufenacil , 2-chloro- 5

- [3 ,6

-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)

- 1

(2H)

-pyrimidinyl] -4-tluoro-N

- [[methyl(l -methylethyl)amino ]sulfonyl]benzamide, and its metabolites N-[2-chloro-5-(2,6

-dioxo-4-(tritluoromethyl)-3 ,6-dihydro

- l (2/-1)-pyrimidinyl) -4

- fluorobenzoyl]-N-isopropylsulfamide and N-[ 

## 4-chloro

-2-fluoro

-5-( {[(isopropylamino )sulfonyl] Page 3 of20

### Saflufenacil Dietary Exposure and Ri sk Assessment DP Number: 426932 

## amino }carbonyl)phenyl]urea, calcula ted as the stoichiometric equi valent of saflufenacil" under 40 CFR 

## § 180.649(a)( 1) for residues on a variety of crops, including but not limited to citrus fruit (Crop Group 10) , pome fruit (Crop Group l l ) , stone fruit (Crop Group 12) , grapes, tree nuts (Crop Group 14), legume vegetables (crop group 06) , the foliage of legume vegetables (crop group 07), cereal grain s (crop group 15), forage , fodder , and straw of cereal grains (crop group 16), cottonseed (subgroup 20C) , rapeseed (subgroup 20A), sunflower (subgroup 20B), coffee , banana, and mango. Addi tionally, permanent tolerances are established for "saflufenacil , including its metabolites and degradates , in or on the commodities in the table below. Compliance with the tolerance levels specified below is to be determined by measuring only sa

flufenaci l, 2-chloro-5-[3 ,6-dihydro-3 -methyl-2 ,6-dioxo -4- (trifluoromethyl)-l (2H)- pyrimidinyl]-4-fluoro-N-[[methyl(l-methylethy l)amino]sulfonyl]benzamide" under 40 CFR § l 80.649(a)(2) for residues on livestock commodities. Recommended Tolerances: Based on th e residue chemistry data submitted with the current petitions, HED recommended for establishment of the following tolerances (G. Kramer, 05- NOV-2015; D422467): Table 2. Tolerance Summary for Safluf enacil. Co mmodity 

## I Recommended Tolerance (oom) 40 CFR §180.649(a)(I) Pomej?,ranate 

## I 0.03 

## Residue Data used for Acute and Chronic Assessments: The acute and chronic assessments were based on the assumption of tolerance- level residues for all commodities , except for cottonseed; sunflower subgroup 20B; soybean , seed; vegetable, legume, subgroup 6C , pea and bean (except soybean); and rapeseed subgroup 20A. For these crops , residues were al so based on the recommended tolerances; however, a correction factor was applied to the tolerance level to account for the M800 H02 metabolite included in the risk assessment as a result ofpreharvest uses. The additional metabolite, M800H02 , was observed in the metabo lism studies ofpreharvest-treated soybean seed, comprising 26.3% of the total radioactive residue s (G. Kramer, 24-MAR-2011; DP# 381129). Since the toxicity of the M800H02 is expected to be comparable to that of the parent compound , it was included in the risk assessment for preharvest uses , but not in the tolerance expression. To account for this additional toxicity exposure, the recommended to lerance level was multiplied by a correction factor of 1.7X, where 1.7 =(Metabolites in Risk Assessment)/(Metabolites in Tolerance Expression). 1.7 

### = (Saflufenacil 

### + M800H 11 

### + M800H02 

### + M800H 35)/(Saf1ufenacil 

### + M800H 11 

### + M800H35) 

### = (26. 1% 

### + 10.9% 

### + 26.3% 

### + 0% )/(26.1% 

### + 10.9% 

### + 0%) 

## Therefore, in the acute and chronic assessments, a residue of 0.34 ppm was used for cottonseed ; a residue of 1. 7 ppm was used for sunflower subgroup 20B; a residue of 0.17 ppm was used for soybean, seed ; a residue of 0.51 ppm was used for vegetable, legume , subgroup 6C , pea and bean (except soybean); and a residue of 0.76 ppm was used for rapeseed subgroup 20A (see Table 3).

Page 4 of20

### Saflufenacil Dietary Exposure and Ri sk Asses s ment DP Number: 426932 Tab le 3. Corrected Residues Used in the C hronic Assess ment. Crop Group and/or 

### Commodity To lerance (oom) Corrected Residue Used in Dietary Assessments 1 

### Cottonseed Subgroup 20C 0.20 0.34 Sunflower Subgroup 20B 

### 1.0 1.7 Soy bean, seed 0.10 0.17 Vegetable, Legume, Subgroup 6C, 0.30 0.51 pea and bean (except soybean) Rapeseed Subgroup 20A 0.45 0.76 1 Tolerance level residues were corrected to account for the addition of the M800H02 metabolite which was observed m the metabolism studies ofpreharvest-treated soy bean seed. The recommended tolerance l evel was multiplied by a correction factor of I.7X, where 1.7 = (Metabolites in Risk Assessmcnt)/(Mctabolitcs in Tolerance Expression). 

## Processing Factors: DEEM 7.81 default processing factors were used for all processed commodities (where provided). 

## III. Percent C rop Treated Inform ation The acute and chronic assessments were based on the assumption of 100% CT for all commodities. 

## IV. Drinki ng Water Data The Estimated Drinking Water Concentrations (EDWCs) used in the dietary exposure risk assessment were provided by the Environmental Fate and Effects Division (EFED) in a memorandum dated 12-MAR-2014 (Memo, M. Ruhman ; DP# 414485) . Water residues were incorporated directly into the DEEM

-FCID into the food categories "water, direct, all sources" and "water, indirect, all sources . " Screening EDWCs (Table 4) of saflufenacil were generated for surface water by Tier I Rice modeling. Modeled application rates represent the maximum use patterns for dry

- seeded rice: the Ist 

## application at planting, the second application 14 days after planting, and flooding at 45 days after planting. Remaining model input parameters were chosen according to current guidance (USEPA, 2002) . EDWCs reflect exposure to saflufenacil and all degradates of concern in drinking water (Table 1).

Table 4. T iered EDWCs for Proposed Saflufenacil Uses. 1

- in-10-year Peak Expos ure l-in-10-year Annual Mean So urce (Tier: Model) (ppb) Exposure (ppb) Surface water (Tier I: Rice Model) 13 3 

### 120 (used in acute analysis) (used in 

### chronic analysis) Ground water (Tier 11 : PRZM GW) 69.2 5 1. 5 

## V. DEEM-FCID Program and Cons umption Information Saflufenacil acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3. 16, which incorporates 2003

-2008 consumption data from USDA's NHANES/WWEIA. The data are based on the r eported consumption of more than 20 ,000 individuals over two non-consecutive survey days. Foods "as consumed" (e.g., apple p ie) are linked to EPA-defined food commodities (e.g., apples, peeled fruit

- cooked; fresh or N/S; baked; or wheat flour

- cooked; fresh or N/S, baked) using publicly available recipe translation files Page 5 of20

### Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

## developed jointly by USDA/ ARS and EPA. For chronic exposure assessment, consumption data are averaged for the entire U.S. population and within population subgroups. However, for acute exposure assessment, consumption data are retained as indi vidual consumption events. Based on analysis of the 2003

-2008 WWEIA consumption data, which took into account dietary patterns and survey respondents , HED concluded that it is most appropriate to report risk for the following population subgroups: the general U.S. population, all infants (< 1-year old), children 1-2, children 3-5, children 6-12 , youth 13

- 19 , adults 20-49, females 13-49, and adults 50-99 years old. For a chronic dietary exposure assessment, an estimate ofthe residue level in eac h food or food

form (e .g., orange or orangejuice) on the food commodity residue list is multiplied by the average daily consumption estimate for t hat food/food form to produce a residue intake estimate. The resulting residue intake estimate fo r each food/food form is summed with the residue intake estimates for all other food/food forms on the commodity residue list to arrive at the total average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent ofthe cPAD . This procedure is performed for each population subgroup. For an acute exposure assessment, individual one-day food consumption data are used on an individual-by-individual basis. The reported consumption amounts ofeach food item can be multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a deterministic exposure assessment, or " matched " in multiple random pairings with residue values and then summed in a probabilistic assessment. The resulting distribution of exposures is expressed as a percentage of the 

## aPAD on both a user (i.e. , only those who reported eatin g relevant commodities/food forms) and a per-capita (i. e . , tho se who reported eating the relevant commodities as well as those who did not) basis . 

## In accordance with HED policy , per capita exposure and risk are r eported for analyses performed at all levels of refinement. However, for deterministic assessments, any significant differences in user vs . per capita exposure and risk are specifically identified and noted in the ri sk assessment. 

## VI. Toxico logical Information

Table 5. S u mmary ofToxicological Doses and Endpoints for Safl ufenaci l for Use in Dietary Human-Health R isk Assessme nt s. Exposure/ Point of Uncertainty/ RID , PAD , Scenar io Departure FQPA SFs LOC for Risk Study and Toxicological Effects Assessment Acute Dietary NOAEL = 500 UFA = !OX Acute RID = Acute Neurotoxicity Study (rat) (General mg/kg/day UFH = !OX 5 .0 mg/kg NOAEL = 500 (M) and 2000 (F) mg/kg/day . Population, LOAEL was 2000 mg/kg/ day (males) based on including FQPA SF = IX aPAD = 5.0 the decreased motor activity representing mild In fants and mg/kg and transient systemic toxicity. Children) LOAEL was not established for females. C hronic NOAEL = 4.6 UFA= IOX C h ronic RID Chronic/Carcinogen icity (mouse) Dietary (All mg/kg/day UFH = IOX = 0.046 NOAEL = 4.6 mg/kg bw/d (males) and 18.9 Popu lations) mg/kg/day mg/kg bw /d (females). FQPA S F = IX LOAELs = I 3.8 mg/kg bw/d (males) and 38.1 cPAD = 0.046 mg/kg bw/day (females) based on decreased mg/kg/day red blood cells , hemog lob in , and hematocrit and oornhvria observed in the sate llite group. Cancer (oral, C lassification: Not ca rc inogenic based on the lack oftumors in the mouse and rat carcinogeoicity dermal , studies and lack of mutagenicity. inhalation) Page 6 of20

### Saflufenaci l Dietary Exposure and Ri sk Assessment DP Number: 426932 NOA EL = no-observed adverse-effect level. LOA EL= lowest-observed adverse-effect level. UF = uncertainty factor. UF" = extrapolat ion from animal to human (i nterspec i es). UFH= potential variation in sensitivity among members ofth e human population (intraspecies). FQ PA SF = FQPA Safety Fact or. PAD = population-adjusted dose (a = acute, c = chronic). RID = reference dose. LOC = level ofconcern. 

## VI I. Results/Discussion For acu t e and chronic assessments, HED is concerned when dietary risk exceeds 100% ofthe PAD. The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and various population subgro up s. The results reported in Table 6 are for the general U.S. popu lati on, all infants (< 1-year o ld), children 1-2 years old, ch ildren 3 -5 years old, children 6-12 years old , yo uth 13 -19 years old, females 13-49 years old, adults 20-49 years old , and adults 50

- 99 years ol d. Results of Acute and Chronic D ietary Exposure Analyses The acute di eta ry risk for food and drinking water utili zed < I% of the aPAD for the U.S. population at the 95Lh percentile ofexposure . The acute di etary ri sk for the highest exposed population subgroup , all infants (< I-year old), is < 1% of the aPAD at the 95t h percentile. The ch ro nic dietary risk for food and drinking water utili zed 9.2% of the cPAD for the U. S. population. The chronic dietary risk for the highest exposed population subgroup, all infants (< I-year o ld), is 20% ofthe cPAD. The results of the acute and chronic dietary exposure analyses are reported in Table 6. Tab le 6. S ummary of Dietary (Food a nd Drinkin2 Water) Ex 1os urc Ri s k for S aflufenacil. Acu te Di etary Chronic Dietary (95 'h Percentile) Popu lation Subgroup Dietary Exposure Dietary Exposure (mg/kg/day) %aPAD (mg/kg/day) %c PAD General U.S. Popul atio n 0 .010106 

### <I 0.004223 9.2 All ln fants (< I-year old) 0.026582 < I 

### 0. 009099 20 Children 1-2 years old 0 .017044 

### <I 0.008368 18 Ch ildren 3-5 years old 0 .013965 

### <I 0.006993 15 Ch ildren 6-12 years old 0.010852 

### < I 0 .004872 11 Youth 13- 19 years old 0.008383 

### < I 0.003409 7.4 Adults 20-49 years o l d 0.009095 

### < I 0.003946 8.6 Adu lts 50-99 years o ld 0.007781 

### < I 0.003679 8 .0 Females 13-49 years o ld 0.009078 

### < I 0.003759 8.2 •The values for the highest exposed population for each type of risk assessment arc boldcd. 

## VIII . C h aracterization of Inputs/Outputs These acute and chronic dietary exposure and ri sk estimates are conservati ve since the y assumed l 00% CT , DEEM 7.81 default concentration fac tors, and to lerance- level or higher residues (fo r so me crops, a correction factor was applied to the tolerance level to account for the M800H02 metabolite) and were based on screening level estimates of drinkin g water concentrations ge nerated by T ier I Rice modeling. They could be furth er refined through the use of anticipated residues, empirical processing factors, and% CT data, as well as re fined drinking water estimates . In order to provide a comparison for reference , the dietary results for the analysis of food expo sures (o nl y) are presented in attachments 5 & 

## 6. Page 7 of20

### Saflufenac il Dietary Exposure and Risk Assessment DP Number: 426932 

## IX. Conclusions The acute and chronic dietary exposure and risk analyses using DEEM-FCID indicates that dietary risks to sa fluf enaci l from food and drinking water are well below HED's levels of concern for this pesticide. Estimated acute dietary risks are < 1 % 

## ofthe aPAD at the 95th 

## percentile for the general U.S . population and aJI population subgroups, and estimated chronic dietary risks are 90% of the cPAD for the general U.S. population and all population subgroups. HED is co nfident that the assessment does not underestimate ri sk to the general U.S. population or any population subgroup. X. List ofAttachments Attachment I: DEEM-FCID Acute Residue File. Attachment 2 : DEEM-FCID Acute Exposure and Risk Estimates Attachment 3: DEEM-FCID Chronic Residue File. Attachment 4: DEEM-FC ID Chronic Exposure and Risk Estimates . Attachment 5: DEEM-FCID Acute Exposure and Risk Estimates (food only). Attachment 6: DEEM-FCID Chronic Exposure and Ri sk Estimates (food only).

cc: G. Kramer (RABI) RDI: DESAC (4/29115) 

### G.F. Kramer:S I0957:PY-S : (703)305-5079:7509P:RAB I Page 8 of20

### S aflufenaci l Dietary Exposure and Risk Assessment DP Number: 426932 

## Attachment 1: DEEM-FCID Acute Residue Fil e. Filename : C : \Users\gkramer\Documents\Gk\##Saflufenacil\SAFLUFENACIL ACUTE . ROB Chemical : Saflufenacil

- RfD(Chronic) : . 046 mg/kg bw/day NOEL(Chronic) : O mg/kg bw/day RfD(Acute) : 5 mg/kg bw/day NOEL(Acute) : 0 mg/kg bw/day Date created/last modified : 03

- 13-2014/09 : 46 : 30 Program ver . 3 . 16 , 03

- 08

- d Crop EPA Code Grp Commodity Name 9500023000 0 9500024000 0 9500024001 0 9500023001 0 9500116000 0 9500115000 0 9500177000 0 9500178000 0 9500215000 0 9500216000 0 9500217000 0 9500217001 0 9500235000 0 9500236000 0 9500283000 0 9500284000 0 9500289000 0 9500363000 0 9500363001 0 9500362000 0 9500362001 0 0603035000 6C 0603030000 6C 0603032000 6C 0602031000 6B 0603034000 6C 0602033000 6B 0603036000 6C 0603038000 6C 0602037000 6B 0603039000 6C 0603040000 6C 0603041000 6C 0603042000 6C 0601043000 6A 0601043001 6A 0603099000 6C 0603098000 6C 0603098001 6C 0603182000 6C 0603182001 6C 0603203000 6C 0603256000 6C 0603256001 6C 0601257000 6A 0603258000 6C 0602259000 6B 0602255000 6B 0602255001 68 0603348000 6C 0603348001 6C 0600350000 6 0600350001 6 0600347000 6 0600349000 6 0600349001 6 100 11 06000 lOA 1001107000 lOA 1001108000 lOA Banana Banana , dried Banana , dried

- babyfood Banana

- babyfood Coffee , instant Coffee , roasted bean Grape , leaves Grape , raisin Mango Mango , dried Mango , juice Mango , juice-babyfood Olive Olive , oil Plantain Plantain , dried Pomegranate Sugarcane , mo l asses Sugarcane , molasses

- babyfood Sugarcane , sugar Sugar cane , sugar-babyfood Bean , great northern , seed Bean , black , seed Bean , broad , seed Bean , broad , succulent Bean , cowpea , seed Bean , cowpea , succulent Bean , kidney , seed Bean , lima , seed Bean , lima , succulent Bean , mung , seed Bean , navy , seed Bean , pink , seed Bean , pinto , seed Bean , snap , succulent Bean , snap , succulent-babyfood Chickpea , flour Chickpea , seed Chickpea , seed

- babyfood Guar , seed Guar , seed-babyfood Lentil , seed Pea , dry Pea , dry-babyfood Pea , edible podded , succulent Pea , pigeon , seed Pea , pigeon , succulent Pea , succulent Pea , succulent-babyfood Soybean , flour Soybean , f lour-babyfood Soybean, oi l Soybean , oil-babyfood Soybean , seed Soybean , soy milk Soybean , soy milk

- babyfood or in Citron Citrus hybrids Citrus , oil Def Res (ppm) 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 080000 0 . 080000 0 . 050000 0 . 050000 0 . 510000 0 . 510000 0 . 510000 0 . 030000 0 . 510000 0 . 030000 0 . 510000 0 . 510000 0 . 030000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 030000 0 . 030000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 030000 0 . 510000 0 . 030000 0 . 030000 0 . 030000 0 . 170000 0 . 170000 0 . 170000 0 . 170000 0 . 170000 0 . 170000 0 . 170000 0 . 030000 0 . 030000 0 . 030000 

### Page 9 of20 Adj . Factors #1 #2 1 . 000 3 . 900 3 . 900 1 . 000 1 . 000 1 . 000 1 . 000 4 . 300 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 Comment

### Saflufenacil Dietary Exposure and Ri sk A ssessment DP Number: 426932 1003180000 lOC Grapefruit 0 . 030000 1 . 000 1 . 000 1003181000 lOC Grapefruit , juice 0 . 030000 2 . 100 1 . 000 1002197000 108 Kumquat 0 . 030000 1 . 000 1 . 000 1002199000 108 Lemon 0 . 030000 1 . 000 1 . 000 1002200000 108 Lemon , juice 0 . 030000 2 . 000 1 . 000 1002200001 108 Lemon , juice-babyfood 0 . 030000 2 . 000 1 . 000 100220 1 000 ! OB Lemon , peel 0 . 030000 1 . 000 1 . 000 1002206000 lOB Lime 0 . 030000 1 . 000 1 . 000 1002207000 108 Lime , juice 0 . 030000 2 . 000 1 . 000 1002207001 108 Lime , juice

- babyfood 0 . 030000 2 . 000 1 . 000 1001240000 lOA Orange 0 . 030000 1 . 000 1 . 000 1001241000 lOA orange , juice 0 . 030000 1 . 800 1 . 000 1001241001 lOA Orange, juice

- babyfood 0 . 030000 1 . 800 1 . 000 1001242000 lOA Orange , peel 0 . 030000 1 . 000 1 . 000 1003307000 lOC Pummelo 0 . 030000 1 . 000 1 . 000 1001369000 lOA Tangerine 0 . 030000 1 . 000 1 . 000 1001370000 lOA Tangerine , juice 0 . 030000 2 . 300 1 . 000 1100009000 11 Apple , dried 0 . 030000 8 . 000 1 . 000 1100009001 11 Apple , dried

- babyfood 0 . 030000 8 . 000 1 . 000 1100007 000 11 Apple , fruit w ith p eel 0 . 030000 1 . 000 1 . 000 1100010000 11 Apple , juice 0 . 030000 1 . 300 1 . 000 1100010001 11 Apple , juice

- babyfood 0 . 030000 1 . 300 1 . 000 1100008000 11 Apple , peeled fruit 0 . 030000 1 . 000 1 . 000 1100008001 11 Apple , peeled fruit

- babyfood 0 . 030000 1 . 000 1 . 000 1100011000 11 Apple , sauce 0 . 030000 1 . 000 1 . 000 1100011001 11 Apple , sauce-babyfood 0 . 030000 1 . 000 1 . 000 1100129000 11 Crabapple 0 . 030000 1 . 000 1 . 000 1100210000 11 Loquat 0 . 030000 1 . 000 1 . 000 1100266000 11 Pear 0 . 030000 1 . 000 1 . 000 1100267000 11 Pear , dried 0 . 030000 6 . 250 1 . 000 1100268000 11 Pear , juice 0 . 030000 1. 000 1 . 000 110026800 1 11 Pear , juice-babyfood 0 . 030000 1. 000 1 . 000 110026600 1 11 Pear-babyfood 0 . 030000 1 . 000 1 . 000 1100310000 11 Quince 0 . 0300 00 1 . 000 1 . 000 1202012000 128 Apricot 0 . 030000 1 . 000 1 . 000 1202013000 128 Apricot , dried 0 . 030000 6 . 000 1 . 000 1202014000 128 Apricot , juice 0 . 030000 1 . 000 1 . 000 1202014001 12B Apricot , juice-babyfood 0 . 030000 1 . 000 1 . 000 1202012001 128 Apricot-babyfood 0 . 030000 1 . 000 1 . 000 1201090000 12A Cherry 0 . 030000 1 . 000 1 . 000 1201091000 12A Cherry , juice 0 . 030000 1 . 500 1 . 000 1201091001 12A Cherry , juice

- babyfood 0 . 030000 1 . 500 1 . 000 1201090001 12A Cherry-babyfood 0 . 030000 1 . 000 1 . 000 1202230000 128 Nectarine 0 . 030000 1 . 000 1 . 000 1202260000 128 Peach 0 . 0300 00 1 . 000 1 . 000 1202261000 128 Peach , dried 0 . 030000 7 . 000 1 . 000 120226 1 00 1 128 Peach , dried-babyfood 0 . 030000 7 . 000 1 . 000 1202262000 128 Peach , juice 0 . 030000 1.000 1 . 000 1202262001 128 Peach , juice

- babyfood 0 . 030000 1 . 000 1 . 000 1202260001 12B Peach-babyfood 0 . 030000 1 . 000 1 . 000 1203285000 12C Plum 0 . 030000 1 . 000 1 . 000 1203287000 12C Plum , prune , dried 0 . 030000 5 . 000 1 . 000 1203287001 12C Plum , prune , dried

- babyfood 0 . 030000 5 . 000 1 . 000 1203286000 12C Plum , prune , fresh 0 . 030000 1 . 000 1 . 000 1203286001 12C Plum , prune , fresh

- baby food 0 . 030000 1 . 000 1 . 000 1203288000 12C Plum , prune , juice 0 . 030000 1. 400 1 . 000 1203288001 12C Plum , prune , juice

- babyfood 0 . 030000 1 . 400 1 . 000 1 20328500 1 1 2C Plum-babyfood 0 . 0300 00 1 . 000 1 . 000 1304 175000 1 30 Grape 0 . 030000 1 . 000 1 . 000 1304176000 130 Grape , juice 0 . 030000 1.200 1 . 000 1304176001 130 Grape , juice-babyfood 0 . 030000 1.200 1 . 000 1304179000 130 Grape , wine and s h erry 0 . 030000 1 . 000 1 . 000 1400003000 H Almond 0 . 030000 1 . 000 1 . 000 1400004000 14 Almond , oil 0 . 030000 1 . 000 1 . 000 1400004001 14 Almond , oil

- babyfood 0 . 030000 1 . 000 1 . 000 1400003001 14 Almond-babyfood 0 . 030000 1 . 000 1 . 000 1400059000 14 Brazil nut 0 . 030000 1 . 000 1 . 000 1400068000 14 Butternut 0 . 030000 1 . 000 1 . 000 1400081000 14 Cashew 0 . 030000 1 . 000 1 . 000 1400092000 14 Chestnut 0 . 030000 1 . 000 1 . 000 1 400 1 55000 1 4 Hazelnut 0 . 030000 1 . 000 1 . 000 

### Page JO o f 20

### Saflu 

### fenaci I Dietary Exposure and Risk Assessment DP Number: 426932 1400156000 14 Hazelnut , oil 0 . 030000 1 . 000 1 . 000 1400185000 

### 14 Hickory 

### nut 0 . 030000 1 . 000 1 . 000 1400213000 14 Macadamia nut 0 . 030000 1 . 000 1 . 000 1400269000 14 Pecan 0 . 030000 1 . 000 1 . 000 1400282000 14 Pistachio 0 . 030000 1 . 000 1 . 000 1400391000 14 Walnut 0 . 030000 1.000 1.000 1500027000 1 5 Barley , bran 1 . 500000 1 . 000 1 . 000 1500026000 1 5 Barley , flour 1 . 000000 1 . 000 1 . 000 1500026001 15 Barley , flo ur- babyfood 1 . 000000 1 . 000 1 . 000 1500025000 15 Barley , pearl ed b ar ley 1 . 000000 1 . 000 1 . 000 1500025001 15 Barley , pearled barley

- babyfood 1 . 000000 1 . 000 1 . 000 1500065000 15 Buckwheat 0 . 030000 1 . 000 1 . 000 1500066000 15 Buckwheat , flour 0 . 030000 1 . 000 1 . 000 1500122000 15 Corn , field , bran 0 . 030000 1 . 000 1 . 000 1500120000 15 Corn , field , flour 0 . 030000 1 . 000 1 . 000 1500120001 15 Corn , field , flour

- babyfood 0 . 030000 1 . 000 1 . 000 1500121000 15 Corn , field , meal 0 . 030000 1 . 000 1 . 000 1500121001 15 Corn , field , meal

- b abyfood 0 . 030000 1 . 000 1 . 000 1500125000 15 Corn , field , oi l 0 . 030000 1 . 000 1 . 000 1500125001 15 Corn , field , oil -baby foo d 0 . 030000 1 . 000 1 . 000 1500123000 15 Corn , field , starch 0 . 030000 1 . 000 1 . 000 150012300 1 15 Corn , field , starch

- baby food 0 . 030000 1 . 000 1 . 000 1500124000 15 Corn , field , syrup 0 . 030000 1 . 500 1 . 000 1500124001 15 Corn , field , syrup -babyfood 0 . 030000 1 . 500 1 . 000 1500126000 15 Corn , pop 0 . 030000 1 . 000 1 . 000 1500127000 15 Corn , sweet 0 . 030000 1 . 000 1 . 000 1500127001 15 Corn , sweet-babyfood 0 . 030000 1 . 000 1 . 000 1500226000 15 Millet , grain 0 . 030000 1 . 000 1 . 000 1500231000 15 Oat , bran 0 . 030000 1 . 000 1 . 000 1500232000 15 Oat , flour 0 . 030000 1 . 000 1 . 000 1500232001 1 5 Oat , flour-babyfood 0 . 030000 1 . 000 1 . 000 1500233000 15 Oat , groats/rolled o a ts 0 . 030000 1 . 000 1 . 000 1500233001 1 5 Oat , groats/rolle d o a ts- b a b yfood 0 . 030000 1 . 000 1 . 000 1500326000 15 Rice , bran 0 . 030000 1 . 000 1 . 000 1500326001 15 Rice , bran-babyfood 0 . 030000 1 . 000 1 . 000 1500324000 15 Rice , brown 0 . 030000 1 . 000 1 . 000 1500324001 15 Rice , brown

- babyfood 0 . 030000 1 . 000 1 . 000 1500325000 15 Rice , flour 0 . 030000 1 . 000 1 . 000 1500325001 15 Rice , flour

- babyfood 0 . 030000 1 . 000 1 . 000 1500323000 15 Rice , white 0 . 030000 1 . 000 1 . 000 1500323001 15 Rice , white-babyfood 0 . 030000 1 . 000 1 . 000 1500329000 15 Rye , flour 0 . 030000 1 . 000 1.000 1500328000 15 Rye , grain 0 . 030000 1 . 000 1 . 000 1500344000 15 Sorghum , grain 0 . 030000 1. 000 1.000 1500345000 1 5 Sorghum , syrup 0 . 030000 1.000 1.000 1500381000 1 5 Triticale , f l our 0 . 030000 1 . 000 1 . 000 1500381001 1 5 Triticale , flou r-bab yf ood 0 . 030000 1 . 000 1 . 000 1500404000 15 Wheat , bran 0 . 600000 1 . 000 1.000 1500402000 15 Wheat , flour 0 . 600000 1 . 000 1 . 000 1500402001 15 Wheat , flour

- babyfood 0 . 600000 1 . 000 1 . 000 1500403000 15 Wheat , germ 0 . 600000 1 . 000 1 . 000 1500401000 15 Wheat , grain 0 . 600000 1 . 000 1 . 000 1500401001 15 Wheat , grain-babyfood 0 . 600000 1 . 000 1 . 000 1500405000 15 Wild rice 0 . 030000 1 . 000 1 . 000 2003128000 20C Cottonseed , oil 0 . 340000 1 . 000 1 . 000 2003128001 20C Cottonseed , oil

- babyfood 0 . 340000 1 . 000 1 . 000 2001163000 20A Flax seed , oil 0 . 760000 1 . 000 1 . 000 2001319000 20A Rapeseed , oil 0 . 760000 1 . 000 1 . 000 2001319001 20A RapeseeGI , oil -ba byfoo d 0 . 760000 1 . 000 1 . 000 2002330000 208 Safflower , oi l 1 . 700000 1 . 000 1 . 000 2002330001 208 Safflower , oil

- babyf ood 1 . 700000 1 . 000 1 . 000 2001337000 20A Sesame , oil 0 . 760000 1 . 000 1 . 000 2001337001 20A Sesame , oil-babyfood 0 . 760000 1 . 000 1 . 000 2001336000 20A Sesame , seed 0 . 760000 1 . 000 1.000 2001336001 20A Sesame , seed-baby food 0 . 760000 1 . 000 1 . 000 2002365000 20B Sunflower , oil 1 . 700000 1 . 000 1 . 000 2002365001 20B Sunflower , oil-babyfood 1 . 700000 1 . 000 1 . 000 2002364000 20B Sunflower , seed 1 . 700000 1 . 000 1 . 000 3100047000 31 Beef , fat 0 . 040000 1 . 000 1 . 000 3100047001 31 Beef , fat-baby f ood 0 . 0 40000 1 . 000 1 . 000 3100048000 31 Beef , kidney 0 . 300000 1 . 000 1 . 000 

### Page 11 of20

### Satlufenacil Dietary Exposure and Ri sk Assessment DP Number: 

### 426932 3100049000 31 Beef , liver 50 . 000000 1 . 000 1 . 000 3100049001 31 Beef , liver

- babyfood 50 . 000000 1 . 000 1 . 000 3100044000 31 Beef , meat 0 . 020000 1 . 000 1 . 000 3100046000 31 Beef , meat byproducts 0 . 300000 1 . 000 1 . 000 3100046001 31 Beef , meat byproducts-babyfood 0 . 300000 1 . 000 1 . 000 3100045000 31 Beef , meat , dried 0 . 020000 1. 920 1.000 3100044001 31 Beef , meat-b abyfood 0 . 020000 1 . 000 1 . 000 3200171000 32 Goat , fat 0 . 040000 1 . 000 1 . 000 3200172000 32 Goat , kidney 0 . 300000 1 . 000 1 . 000 3200173000 32 Goat , liver 50 . 000000 1 . 000 1.000 3200169000 32 Goat , meat 0 . 020000 1 . 000 1 . 000 3200170000 32 Goat , meat byproducts 0 . 300000 1 . 000 1 . 000 3300189000 33 Horse , meat 0 . 020000 1 . 000 1 . 000 3400293000 34 Pork , fat 0 . 010000 1 . 000 1 . 000 3400293001 34 Pork , fat-babyfood 0 . 010000 1 . 000 1 . 000 3400294000 34 Pork , kidney 0 . 010000 1 . 000 1 . 000 3400295000 34 Pork , liver 2 . 000000 1 . 000 1 . 000 3400290000 34 Pork , meat 0 . 010000 1 . 000 1 . 000 3400292000 3 4 Pork , meat byproducts 0 . 020000 1 . 000 1 . 000 340029200 1 34 Pork , meat byprod uc t s-babyfood 0 . 020000 1 . 000 1 . 000 340029000 1 34 Pork , meat-babyfood 0 . 010000 1 . 000 1 . 000 3400291000 34 Pork , skin 0 . 010000 1 . 000 1 . 000 3500341000 35 Sheep , fat 0 . 040000 1 . 000 1 . 000 3500341001 35 Sheep , fat-babyfood 0 . 040000 1 . 000 1 . 000 3500342000 35 Sheep , kidney 0 . 300000 1 . 000 1 . 000 3500343000 35 Sheep , liver 50 . 000000 1 . 000 1 . 000 3500339000 35 Sheep , meat 0 . 020000 1 . 000 1 . 000 3500340000 35 Sheep , meat byproducts 0 . 300000 1 . 000 1 . 000 3500339001 35 Sheep , meat-babyfood 0 . 020000 1 . 000 1 . 000 3600222000 36 Milk , fat 0 . 010000 1 . 000 1 . 000 3600222001 36 Milk , fat-baby food/infant formu 0 . 010000 1 . 000 1 . 000 3600223000 36 Milk , nonfat solids 0 . 010000 1 . 000 1 . 000 360022300 1 36 Milk , nonfat solids

- baby food/in 0 . 010000 1 . 000 1 . 000 3600225001 36 Milk , sugar (lactose)

- baby food/ 0 . 010000 1 . 000 1.000 3600224000 36 Milk , water 0 . 010000 1 . 000 1 . 000 3600224001 36 Milk , water- babyfood/infant form 0 . 010000 1 . 000 1 . 000 3900312000 39 Rabbit , meat 0 . 010000 1 . 000 1 . 000 8000157000 80 Fish-freshwater finfish 0 . 010000 1.000 1 . 000 8000158000 80 Fish-freshwater finfish , farm ra 0 . 010000 1 . 000 1 . 000 8000160000 80 Fish-saltwater finfish , other 0 . 010000 1 . 000 1 . 000 8000159000 80 Fish-saltwater finfish , tuna 0 . 010000 1 . 000 1 . 000 8000161000 80 Fish-shellfish , crustacean 0 . 010000 1 . 000 1 . 000 8601000000 86A Water , direct , all sources 0 . 133000 1 . 000 1 . 000 8602000000 86B Water , indirect , all sources 0 . 133000 1 . 000 1 . 000



### Page 12 of20

### Saflufenaci l Dietary Exposur e 

### and Risk Assessment DP Number: 426932 

## Attachmen t 2: DEEM-FCID Acute Exposure and Risk Estimates. US EPA DEEM-FCID ACUTE Analysis for SAFLUFENACIL Residue file : SAFLUFENACIL ACUTE . ROS Ver . 3 . 18 , 03

- 08

- d NHANES 2003

- 2008 2

- Day Adjustment factor #2 NOT used . file dated : 04

- 23

- 2015/14 : 45 : 35 Analysis Date : 04

- 23

- 2015/l4 : 51 : 05 Residue RAC/FF intake sununed over 24 hours Run Comment : "" Sununary calculations--per capita : 95th Percentile 99th Percentile 99 . 9th Percentile Exposure % aRfD Exposure % aRfD Exposure % aRfD



## ---------- -------- 

## ---------- ------- - 

# ---------- -------- Total 

### us Population : 0 . 010106 0 . 20 0 . 015835 0 . 32 0 . 034046 0 . 68 All Infants : 0 . 026582 0 . 53 0 . 035623 0 . 71 0 . 050604 1.01 Children 1

- 2 : 0 . 017044 0 . 34 0 . 025485 0 . 51 0 . 048980 0 . 98 Children 3-5 : 0 . 013965 0 . 28 0 . 019801 0 . 40 0 . 028593 0 . 57 Children 6-12 : 0 . 010852 0 . 22 0 . 015593 0 . 31 0 . 026214 0 . 52 Youth 13

- 19 : 0 . 008383 0 . 17 0 . 013120 0 . 26 0 . 018 114 0 . 36 Adults 20-49 : 0 . 009095 0 . 1 8 0 . 012821 0 . 26 0 . 023217 0 . 4 6 Adults 50-99 : 0 . 007781 0 . 16 0 . 011959 0 . 24 0 . 052739 1. 05 Female 13-49 : 0 . 009078 0 . 18 0 . 012576 0 . 25 0 . 019768 0 . 40



### Page 13 of20

### Saflufenacil Dietary Exposure and Ri sk Assessment DP Number: 426932 

## A ttachment 3: DEEM- FCID Chronic Res idue File. Filename : C : \Users\gkramer\Documents\Gk\##Saflufenacil\SAF LUFENACIL CHRONIC . ROB Chemical : Saflufenacil

- RfD(Chronic) : . 046 mg/kg bw/day NOEL(Chronic) : 0 mg/kg bw / d ay RfD(Acute) : 5 mg/kg bw/day NOEL(Acute) : 0 mg/kg bw /day Date created/last modified : 03- 1 3

- 2014/09 : 47 : 24 Program ver . 3 . 16 , 03-08-d Crop EPA Code Grp Commodity Name 9500023000 0 9500024000 0 9500024001 0 9500023001 0 9500116000 0 9500115000 0 9500177000 0 9500178000 0 9500215000 0 9500216000 0 9500217000 0 9500217001 0 9500235000 0 9500236000 0 9500283000 0 9500284000 0 9500289000 0 9500363000 0 9500363001 0 9500362000 0 9500362001 0 0603035000 6C 0603030000 6C 0603032000 6C 0602031000 6B 0603034000 6C 0602033000 6B 0603036000 6C 0603038000 6C 0602037000 6B 0603039000 6C 0603040000 6C 0603041000 6C 0603042000 6C 0601043000 6A 0601043001 6A 0603099000 6C 0603098000 6C 0603098001 6C 0603182000 6C 0603182001 6C 0603203000 6C 0603256000 6C 0603256001 6C 0601257000 6A 0603258000 6C 0602259000 6B 0602255000 6B 0602255001 6B 0603348000 6C 0603348001 6C 0600350000 6 0600350001 6 0600347000 6 0600349000 6 0600349001 6 1001106000 lOA 1001107000 lOA 1001108000 lOA Banana Banana , dried Banana , dried

- babyfood Banana-babyfood Coffee , instant Coffee , roasted bean Grape , leaves Grape , raisin Mango Mango , dried Mango , juice Mango , Juice

- babyfood Olive Olive , oil Plantain Plantain , dried Pomegranate Sugarcane , molasses Sugarcane , molasses-babyfood Sugarcane , sugar Sugarcane , sugar - bab yfood Bean , great northern , seed Bean , black , seed Bean , broad , seed Bean , broad , succulent Bean , Bean , Bean , Bean , cowpea, seed cowpea, succulent kidney , seed lima , seed Bean , lima , succulent Bean , mung , seed Bean , navy , seed Bean , pink , seed Bean , pinto , seed Bean , snap , succulent Bean , snap , succulent

- babyfood Chickpea , flour Chickpea , seed Chickpea , seed

- babyfood Guar , seed Guar , seed-babyfood Lentil, seed Pea , dry Pea , dry-babyfood Pea , edible podded , succulent Pea , pigeon , seed Pea , pigeon , succulent Pea , succulent Pea , succulent-babyfood Soybean , flour Soybean , flour-babyfood Soybean , oil Soybean , oil-babyfood Soybean , seed Soybean , soy milk Soybean , soy milk

- babyfood or in Citron Citrus hybrids Citrus , oil Def Res (ppm) 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 030000 0 . 080000 0 . 080000 0 . 050000 0 . 050000 0 . 510000 0 . 510000 0 . 510000 0 . 030000 0 . 510000 0 . 030000 0 . 510000 0 . 510000 0 . 030000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 030000 0 . 030000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 510000 0 . 030000 0 . 510000 0 . 030000 0 . 030000 0 . 030000 0 . 170000 0 . 170000 0 . 170000 0 . 170000 0 . 170000 0 . 170000 0 . 170000 0 . 030000 0 . 030000 0 . 030000 

### Page 14 of20 Adj . Factors Comment #1 #2 1 . 000 3 . 900 3 . 900 1 . 000 1 . 000 1 . 000 1 . 000 4 . 300 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1.000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000 1 . 000

### Satlufenacil Dietary Exposure and Ri sk Assessment DP Number: 426932 1003180000 lOC Grapefru it 0 . 030000 1 . 000 1 . 000 1003181000 lOC Grapefruit , juice 

### 0 . 030000 2 . 100 1.000 1002197000 lOB Kumquat 0 . 030000 1 . 000 1 . 000 1002199000 lOB Lemon 0 . 030000 1 . 000 1 . 000 1002200000 lOB Lemon , juic e 0 . 030000 2 . 000 1 . 000 1002200001 lOB Lemon , juice

- babyfood 0 . 030000 2 . 000 1 . 000 1002201000 lOB Lemon , peel 0 . 030000 1 . 000 1 . 000 1002206000 lOB Lime 0 . 030000 1 . 000 1 . 000 1002207000 lOB Lime , juice 0 . 030000 2 . 000 1 . 000 1002207001 lOB Lime , juice -babyfood 0 . 030000 2 . 000 1 . 000 1001240000 lOA Orange 0 . 030000 1 . 000 1 . 000 1001241000 lOA Orange , ) Ul.Ce 0 . 030000 1 . 800 1 . 000 1001241001 lOA Orange , j uice

- babyfood 0 . 030000 1 . 800 1 . 000 1001242000 lOA Orange , peel 0 . 030000 1 . 000 1 . 000 1003307000 lOC Pummelo 0 . 030000 1 . 000 1 . 000 1001369000 lOA Tangerine 0 . 030000 1 . 000 1 . 000 1001370000 lOA Tangerine , juice 0 . 030000 2 . 300 1 . 000 1100009000 11 Apple , dried 0 . 030000 8 . 000 1 . 000 1100009001 11 Apple , dried-b abyfood 0 . 030000 8 . 000 1 . 000 1100007000 11 Apple , fruit w i th peel 0 . 030000 1 . 000 1 . 000 1100010000 11 Apple , j uice 0 . 030000 1 . 300 1 . 000 1100010001 11 Apple , j uice-babyfood 0 . 030000 1 . 300 1 . 000 1100008000 11 App l e , peeled fru it 0 . 030000 1 . 000 1 . 000 1100008001 11 Apple , peeled fruit

- babyfood 0 . 030000 1 . 000 1 . 000 1100011000 11 Apple , sauce 0 . 030000 1 . 000 1 . 000 1100011001 11 Apple , sauce-babyfood 0 . 030000 1 . 000 1 . 000 1100129000 11 Cr abapple 0 . 030000 1 . 000 1 . 000 1100210000 11 Loquat 0 . 030000 1 . 000 1 . 000 1100266000 11 Pear 0 . 030000 1 . 000 1.000 1100267000 11 Pear , dried 0 . 030000 6 . 250 1 . 000 1100268000 11 Pear , juice 0 . 030000 1 . 000 1 . 000 1100268001 11 Pear , juice

- babyfood 0 . 030000 1 . 000 1 . 000 1100266001 11 Pear-babyfood 0 . 030000 1.000 1 . 000 1100310000 11 Quince 0 . 030000 1 . 000 1 . 000 1202012000 12B Apricot 0 . 030000 1 . 000 1 . 000 1202013000 12B Apricot , dried 0 . 030000 6 . 000 1 . 000 1202014000 12B Apricot , juice 0 . 030000 1 . 000 1 . 000 1202014001 12B Apricot , juice-babyfood 0 . 030000 1 . 000 1 . 000 1202012001 12B Apricot-babyfood 0 . 030000 1 . 000 1 . 000 1201090000 12A Che rry 0 . 030000 1 . 000 1 . 000 1201091000 12A Cherry , juice 0 . 030000 1 . 500 1 . 000 1201091001 12A C herry , juice-babyfood 0 . 030000 1 . 500 1 . 000 1201090001 12A Cherry-babyfood 0 . 030000 1 . 000 1 . 000 1202230000 12B Nectarine 0 . 030000 1 . 000 1 . 000 1202260000 12B Peach 0 . 030000 1 . 000 1 . 000 1202261000 128 Peach , dried 0 . 030000 7 . 000 1 . 000 1202261001 12B Peach , dried

- babyfood 0 . 030000 7 . 000 1 . 000 1202262000 12B Peach , j uice 0 . 030000 1 . 000 1 . 000 1202262001 1 2B Peach , juice

- babyfood 0 . 030000 1 . 000 1 . 000 1202260001 12B Peach-babyf ood 0 . 030000 1 . 000 1 . 000 1203285000 12C Plum 0 . 030000 1 . 000 1 . 000 1203287000 12C Plum , prune , dried 0 . 030000 5 . 000 1 . 000 1203287001 12C Plum , prune , dried-babyfood 0 . 030000 5 . 000 1 . 000 1203286000 12C Plum , prune , fresh 0 . 030000 1 . 000 1 . 000 1203286001 12C Plum , prune , fresh-babyfo od 0 . 030000 1 . 000 1 . 000 1203288000 12C Plum , prune , juice 0 . 030000 1. 400 1 . 000 1203288001 12C Plum , prune , juice -bab y fo od 0 . 030000 1. 400 1 . 000 1203285001 12C Plum-babyfood 0 . 030000 1 . 000 1 . 000 1304175000 130 Grape 0 . 030000 1 . 000 1 . 000 1304176000 130 Grape , juice 0 . 030000 1 . 200 1 . 000 1304176001 130 Grape , juice -babyfood 0 . 030000 1 . 200 1 . 000 1304179000 130 Grape , wine and sherry 0 . 030000 1 . 000 1 . 000 1400003000 14 A lmond 0 . 030000 1 . 000 1 . 000 1400004000 14 Almond , oil 0 . 030000 1 . 000 1 . 000 1400004001 14 Almond , oil-b abyfood 0 . 030000 1 . 000 1 . 000 1400003001 14 Almond-babyfood 0 . 030000 1 . 000 1 . 000 1400059000 14 Brazil nut 0 . 030000 1 . 000 1 . 000 1400068000 1 4 Butternut 0 . 030000 1 . 000 1 . 000 1400081000 1 4 Cash ew 0 . 030000 1 . 000 1 . 000 1400092000 14 Chestnut 0 . 030000 1 . 000 1 . 000 1400155000 1 4 Hazelnut 0 . 030000 1 . 000 1 . 000 

### P

age 15 of20

### Satlufenacil Dietary Exposure and Risk Assessment DP Number: 426932 1400156000 14 Hazelnut , oil 0 . 030000 1 . 000 1 . 000 1400185000 14 Hickory nut 0 . 030000 1 . 000 1 . 000 1400213000 14 Macadamia nut 0 . 030000 1 . 000 1 . 000 1400269000 14 Pecan 0 . 030000 1 . 000 1.000 1400282000 14 Pistachio 0 . 030000 1 . 000 1 . 000 1400391000 14 Walnut 0 . 030000 1 . 000 1.000 1500027000 15 Barley , bran 1 . 500000 1 . 000 1 . 000 1500026000 1 5 Barley , flour 1 . 000000 1 . 000 1 . 000 150002 6001 15 Barley , flour-bab yfood 1 . 000000 1 . 000 1 . 000 1500025000 15 Barley , pearled barley 1 . 000000 1 . 000 1 . 000 1500025001 15 Barley , pearled barley-babyfood 1 . 000000 1 . 000 1 . 000 1500065000 15 Buckwheat 0 . 030000 1 . 000 1 . 000 1500066000 15 Buckwheat , flour 0 . 030000 1 . 000 1 . 000 1500122000 15 Corn , field , bran 0 . 030000 1.000 1 . 000 1500120000 15 Corn , field , flour 0 . 030000 1 . 000 1 . 000 1500120001 15 Corn , field , flour-babyfood 0 . 030000 1 . 000 1 . 000 1500121000 15 Corn , field , meal 0 . 030000 1 . 000 1 . 000 1500121001 15 Corn , field , meal

- babyfood 0 . 030000 1 . 000 1 . 000 1500125000 15 Corn , field , oil 0 . 030000 1 . 000 1 . 000 150012500 1 15 Corn , field , oil -babyfood 0 . 030000 1 . 000 1 . 000 1500123000 15 Corn , field , starch 0 . 030000 1 . 000 1 . 000 1500123001 15 Corn , field , starch

- babyfood 0 . 030000 1 . 000 1 . 000 1500124000 15 Corn , field , syrup 0 . 030000 1 . 500 1 . 000 1500124001 15 Corn , field , syrup- babyfood 0 . 030000 1 . 500 1 . 000 1500126000 15 Corn , pop 0 . 030000 1 . 000 1 . 000 1500127000 15 Corn , sweet 0 . 030000 1 . 000 1 . 000 1500127001 15 Corn , sweet-babyfood 0 . 030000 1 . 000 1 . 000 1500226000 15 Millet , grain 0 . 030000 1 . 000 1 . 000 1500231000 15 Oat , bran 0 . 030000 1 . 000 1 . 000 1500232000 15 Oat , flour 0 . 030000 1 . 000 1 . 000 1500232001 15 Oat , flour

- babyfood 0 . 030000 1 . 000 1 . 000 1500233000 15 Oat , groats/rolled oats 0 . 030000 1 . 000 1 . 000 1500233001 15 Oat , groats/rolled oats - babyfood 0 . 030000 1 . 000 1 . 000 1500326000 15 Rice , bran 0 . 030000 1 . 000 1 . 000 1500326001 1 5 Rice , bran-babyfood 0 . 030000 1 . 000 1.000 1500324000 15 Rice , brown 0 . 030000 1 . 000 1 . 000 1500324001 15 Rice , brown-baby food 0 . 030000 1 . 000 1 . 000 1500325000 15 Rice , flour 0 . 030000 1 . 000 1 . 000 1500325001 15 Rice , flour-babyfood 0 . 030000 1 . 000 1 . 000 1500323000 15 Rice, white 0 . 030000 1 . 000 1 . 000 1500323001 15 Rice , white-babyfood 0 . 030000 1 . 000 1 . 000 1500329000 15 Rye , flour 0 . 030000 1 . 000 1 . 000 1500328000 15 Rye , grain 0 . 030000 1 . 000 1 . 000 1500344000 1 5 Sorghum , grain 0 . 030000 1 . 000 1 . 000 1500345000 15 Sorghum , syrup 0 . 030000 1 . 000 1 . 000 1500381000 15 Triticale , f l our 0 . 030000 1 . 000 1 . 000 1500381001 15 Triticale , flour-babyfood 0 . 030000 1 . 000 1 . 000 1500404000 15 Wheat , bran 0 . 600000 1 . 000 1 . 000 1500402000 15 Wheat , flour 0 . 600000 1 . 000 1.000 1500402001 15 Wheat , flour-babyfood 0 . 600000 1 . 000 1 . 000 1500403000 15 Wheat , germ 0 . 600000 1 . 000 1 . 000 1500401000 15 Wheat , grain 0 . 600000 1 . 000 1 . 000 1500401001 15 Wheat , grain

- babyfood 0 . 600000 1 . 000 1 . 000 1500405000 15 Wild rice 0 . 030000 1.000 1 . 000 2003128000 20C Cottonseed , oil 0 . 340000 1 . 000 1 . 000 2003128001 20C Cottonseed , oil

- babyfood 0 . 340000 1 . 000 1 . 000 2001163000 20A Flax seed , oil 0 . 760000 1 . 000 1 . 000 2001319000 20A Rapeseed , oil 0 . 760000 1 . 000 1 . 000 200131900 1 20A Rapeseed , oil-babyfood 0 . 760000 1 . 000 1 . 000 2002330000 20B Safflower , oil 1 . 700000 1 . 000 1.000 200233000 1 20B Safflower , oil-b abyfood 1 . 700000 1 . 000 1 . 000 2001337000 20A Sesame , oil 0 . 760000 1 . 000 1 . 000 2001337001 20A Sesame , oil-babyfood 

## o. 760000 1 . 000 1 . 000 2001336000 20A Sesame , seed 0 . 760000 1.000 1 . 000 2001336001 20A Sesame , seed -babyfood 0 . 760000 1 . 000 1 . 000 2002365000 20B Sunflower , oil l . 700000 1 . 000 1 . 000 2002365001 20B Sunflower , oil

- babyfood 1 . 700000 1 . 000 1.000 2002364000 20B Sunflower , seed 1 . 700000 1 . 000 1 . 000 3100047000 31 Beef , fat 0 . 040000 1 . 000 1 . 000 31000 47001 31 Beef , fat-baby foo d 0 . 040000 1 . 000 1 . 000 3100048000 31 Beef , kidney 0 . 300000 1 . 000 1 . 000 

### P

age 16 of20Saflufenaci l Dietary Exposure and Risk Assessment 

### DP Number: 

### 426932 3100049000 31 Beef , liver 50 . 000000 1 . 000 1.000 3100049001 31 Beef, liver-babyfood 50 . 000000 1 . 000 1 . 000 3100044000 31 Beef , meat 0 . 020000 1 . 000 1 . 000 3100046000 31 Beef , meat byproducts 0 . 300000 1 . 000 1 . 000 3100046001 31 Beef , meat byproducts

- babyfood 0 . 300000 1 . 000 1 . 000 3100045000 31 Beef , meat , dried 0 . 020000 1 . 920 1.000 3100044001 31 Beef , meat - babyfood 0 . 020000 1 . 000 1 . 000 3200171000 32 Goat , fat 0 . 040000 1 . 000 1 . 000 3200172000 32 Goat , kidney 0 . 300000 1 . 000 1 . 000 3200173000 32 Goat , liver 50 . 000000 1 . 000 1 . 000 3200169000 32 Goat , meat 0 . 020000 1 . 000 1 . 000 3200170000 32 Goat , meat byproducts 0 . 300000 1 . 000 1 . 000 3300189000 33 Horse , meat 0 . 020000 1 . 000 1 . 000 3400293000 34 Pork , fat 0 . 010000 1 . 000 1 . 000 3400293001 34 Pork , fat-babyfood 0 . 010000 1 . 000 1 . 000 3400294000 34 Pork , kidney 0 . 010000 1 . 000 1 . 000 3400295000 34 Pork , liver 2 . 000000 1 . 000 1 . 000 3400290000 34 Pork , meat 0 . 010000 1 . 000 1 . 000 3400292000 34 Pork , meat byproducts 0 . 020000 1 . 000 1 . 000 3400292001 34 Pork , meat byproducts-babyfood 0 . 020000 1 . 000 1.000 3400290001 34 Pork , meat-babyfood 0 . 010000 1 . 000 1 . 000 3400291000 34 Pork , skin 0 . 010000 1.000 1.000 3500341000 35 Sheep , fat 0 . 040000 1 . 000 1 . 000 3500341001 35 Sheep , fat

- babyfood 0 . 040000 1 . 000 1 . 000 3500342000 35 Sheep , ki dney 0 . 300000 1 . 000 1 . 000 3500343000 35 Sheep , liver 50 . 000000 1 . 000 1 . 000 3500339000 35 Sheep , meat 0 . 020000 1 . 000 1 . 000 3500340000 35 Sheep , meat byproducts 0 . 300000 1 . 000 1 . 000 3500339001 35 Sheep , meat-babyfood 0 . 020000 1 . 000 1 . 000 3600222000 36 Milk , fat 0 . 010000 1 . 000 1 . 000 3600222001 36 Milk , fat-baby food/infant forrnu 0 . 010000 1 . 000 1 . 000 3600223000 36 Milk , nonfat solids 0 . 010000 1 . 000 1 . 000 3600223001 36 Milk , nonfat solids-baby food/in 0 . 010000 1 . 000 1 . 000 3600225001 36 Milk , sugar (lactose)-baby food/ 0 . 010000 1 . 000 1 . 000 3600224000 36 Milk , water 0 . 010000 1 . 000 1 . 000 3600224001 36 Milk , water-babyfood/infant form 0 . 010000 1 . 000 1 . 000 3900312000 39 Rabbit, meat 0 . 010000 1 . 000 1 . 000 8000157000 80 Fish-freshwater finfish 0 . 010000 1 . 000 1 . 000 8000158000 80 Fish

- freshwater finfish , farm ra 0 . 010000 1 . 000 1 . 000 8000160000 80 Fish

- saltwater finfish , other 0 . 010000 1.000 1 . 000 8000159000 80 Fish

- saltwater finfish , tuna 0 . 010000 1.000 1 . 000 8000161000 80 Fish-shellfish , crustacean 0 . 010000 1 . 000 1.000 8601000000 86A Water , direct , all sources 0 . 120000 1 . 000 1 . 000 8602000000 86B Water , indirect , all sources 0 . 120000 1 . 000 1 . 000



### Page 17 of20

### Saflufenacil Dietary Exposure and Ri sk Assessment DP Number: 426932 

## Attachment 4: D EEM-FCID Chronic Exposure and Risk Es timates. US EPA Ver . 3 . 16 , 03-08

- d DEEM-FCID Chronic analysis for SAFLUFENACIL NHANES 2003-2008 2

- day Residue file name : C : \Users\gkramer\Documents\Gk\#ftSaflufenacil\SAFLUFENACIL_CHRONIC . R08 Adjustment factor #2 used . Analysis Date 04-23-2015/14 : 47 : 31 Residue file dated : 04-23-2015/14 : 44 : 13 Reference dose (RfD , Chronic) = . 046 mg/kg bw/day Total exposure by population subgroup Total Exposure Population

Subgroup Total US Population Hispanic Non-Hisp-White Non-Hisp-Black Non-Hisp-Other Nursing Infants Non-Nursing Infants Female 13+ PREG Children 1-6 Children 7-12 Male 13-19 Female 13-19/NP Male 20+ Female 20+/NP Seniors 55+ All Infants Female 13-50 Children 1-2 Children 3-5 Children 6-12 Youth 13-19 Adults 20-49 Adults 50-99 Female 13-49 mg/kg body wt/day 0 . 004223 0 . 004317 0 . 004263 0 . 003716 0 . 004652 0 . 003456 0 . 011620 0 . 003713 0 . 007392 0 . 004597 0 . 003445 0 . 003378 0 . 003891 0 . 003785 0 . 003608 0 . 009099 0 . 003756 0 . 008368 0 . 006993 0 . 004872 0 . 003409 0 . 003946 0 . 003679 0 . 003759



### Page 18 of20 Percent of Rfd 9 . 2% 9 . 4% 9 . 3% 8 . 1% 10 . 1%

7 . 5% 25 . 3%

8 . 1% 16 . 1% 10 . 0%

7 . 5% 7 . 3% 8 . 5 % 8 . 2 % 7 . 8 % 19 . 8 %

8 . 2 % 18 . 2% 15 . 2% 10 . 6%

7 . 4% 8 . 6% 8 . 0% 8 . 2%

### Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

## Attachment 5 : DEEM-FCID Acute Exposure and Risk Estimates US EPA DEEM-FCID ACUTE Analysis for SAFLUFENACIL Residue file : SAFLUFENACIL Food0nl y . R08 Analysis Date : 04-23-2015/l4 : 52 : 46 Residue Ver . 3 . 18 , 03-08-d NHANES 2003

- 2008 2-Day Adjustment factor #2 NOT used . file dated : 04-23-2015/14 : 44 : 54 RAC/FF intake summed over 24 hours Run Comment : "" 

### =============================================================================== Summary calculations

-- per capita : 95th Percentile 99th Percentile 99 . 9t h Percentile Exposure % aRfD Exposure % aRfD Exposure % a RfD



# ---------- -------- 

# ------- --- -------- 

# ---------- -- ------ Total 

### us Population : 0 . 004477 0 . 09 0 . 007208 0 . 14 0 . 015677 0 . 31 All Infants : 0 . 006 1 90 0 . 12 0 . 009403 0 . 19 0 . 015002 0 . 30 Children 1-2 : 0 . 008661 0 . 17 0 . 012648 0 . 25 0 . 024996 0 . 50 Children 3

- 5 : 0 . 007521 0 . 15 0 . 009929 0 . 20 0 . 012606 0 . 25 Children 6

- 12 : 0 . 005503 0 . 11 0 . 007804 0 . 16 0 . 013281 0 . 27 Youth 13-19 : 0 . 003519 0 . 07 0 . 0056 1 9 0 . 11 0 . 010282 0 . 21 Adults 20

- 49 : 0 . 003337 0 . 07 0 . 005336 0 . 11 0 . 011284 0 . 23 Adults 50-99 : 0 . 002441 0 . 05 0 . 003862 0 . 08 0 . 051384 !. 03 Female 13

- 49 : 0 . 002837 0 . 06 0 . 004470 0 . 09 0 . 008087 0 . 16



### Page 19 

### of20

### Saflufenacil Dietary Exposure and Ri sk Assessment DP Number: 426932 

## Attachment 6: DEEM-FCID Chronic Exposure and Risk Estimates (food only) . US EPA Ver . 3 . 16 , 03

- 08

- d DEEM-FCID Chronic a n alysis for SAFLUFENACIL NHANES 2003

- 2008 2-day Residue file name : C : \Users\gkramer\Documents\Gk\#NSaflufenacil\SAFLUFENACIL

_ FoodOnly . R08 Adjustment factor #2 used . Analysis Date 04-23-2015/14 : 49 : 22 Res idue file dated : 04-23-2015/14 : 44 : 54 Reference dose ( RfD , Chronic) = . 046 mg/kg bw/day

Population

Subgroup Total US Population Hispanic Non-Hisp-White Non-Hisp-Black Non

- Hisp

- Other Nursing Infants Non

- Nursing Infants Female 13+ PREG Children 1-6 Children 7

- 12 Male 13-19 Female 13-19/NP Male 20+ Female 20+/NP Seniors 55+ All Infants Female 13

- 50 Children 1-2 Children 3-5 Children 6

- 12 Youth 13

- 19 Adults 20-49 Adults 50

- 99 Fema le 13 -49 Total exposure by popu l ation subgroup Total Exposure mg/kg body wt/day 0 . 001710 0 . 001918 0 . 001678 0 . 001643 0 . 001756 0 . 001183 0 . 003263 0 . 001347 0 . 004173 0 . 002503 0 . 001717 0 . 001442 0 . 001550 0 . 001146 0 . 001178 0 . 002620 0 . 001255 0 . 004743 0 . 003939 0 . 002669 0 . 001577 0 . 001439 0 . 001201 0 . 001261



### Page 20 of20 Percent of Rfd3 . 7% 4 . 2% 3 . 6% 3 . 6 % 3 . 8 % 2 . 6 % 7 . 1 % 2 . 9 % 9 . 1 % 5 . 4 % 3 . 7 % 3 . 1% 3 . 4 % 2 . 5 % 2 . 6 % 5 . 7 % 2 . 7 % 10 . 3 % 8 . 6 % 5 . 8 % 3 . 4 % 3 . 1 % 2 . 6 % 2 . 7%