Federal Register / Vol. 59, No. 249 / Thursday December 29, 1994 / Notices

ENVIRONMENTAL PROTECTION

AGENCY

[OPPTS-41042; FRL-4923-2]

Thirty-Fifth Report of the TSCA

Interagency Testing Committee to the

Administrator Receipt of Report,

Request for Comments, Solicitation of

Interested Parties in Developing

Testing Consent Agreement

AGENCY: Environmental Protection

Agency (EPA).

ACTION: Notice.

SUMMARY* The TSCA Interagency

Testing Committee (ITC), establishedunder section 4(e) of the Toxic

Substances Control Act (TSCA),

transmitted its Thirty-Fifth Report to the

Administrator of EPA on November 3,

1994. As noted in this Report, which is

included with this notice, the ITC

revised the Priority Testing List by

designating a group of 25 chemicals to

the List for priority consideration by the

Administrator for promulgation of test

rules under section 4(a) of the Act.

These chemicals are designated for

response within 12 months. Therefore,

in response to the ITC's designation,

EPA will either initiate rulemaking

under section 4(a) of TSCA, enter into

a testing consent agreement, or publish

a Federal Register notice explaining the

reasons for not initiating such

rulemaking within 12 months. The ITC

also removed 110 of 123 previously

recommended chemicals from the List.

The ITC removed 28 of 43 isocyanates,

27 of 89 aldehydes, 25 of 26 sulfones,

7 of 11 cyanoacrylates, 4 of 14 diaryl

ethers and 19 of 35 chemicals originally

recommended for subchronic (90-day)

toxicity testing. The ITC's reasons for

removing these chemicals from the List

are listed in the Thirty-Fifth Report.

There are no recommended with intentto-designate or recommended chemicals

or chemical groups in the Thirty-Fifth

Report. EPA invites interested persons

to submit written comments on the

Report.

In addition, EPA is soliciting

interested parties for participation in or

monitoring of a TSCA section 4 testing

consent agreement development process

for the chemicals that were designated

for dermal absorption testing. EPA is

also inviting manufacturers and/or

processors of chemical substances who

wish to participate in testing

negotiations for the chemicals

designated for dermal absorption testing

,to develop and submit testing agreement

proposals to EPA.

DATES: Written comments on the ThirtyFifth ITC Report should be submitted by

January 30, 1995. Written testing

proposals must be received by February

27 1995. Written notice of interest in

being designated an "interested party"

to the development or monitoring of a

consent agreement for the chemicals

designated for dermal absorption testing.

must be received by February 27 1995.

Those submitting written testing

proposals will be considered "interested

parties" and do not have to submit

separate written notice. EPA will

contact all "interested parties" and

advise them of meeting dates.

ADDRESSES: Send six copies of written

submissions to: TSCA Nonconfidential

Information Center (7407), Office of

Pollution Prevention and Toxics,

Environmental Protection Agency Rm.

B-607 NEM, 401 M St., SW.,

Washington, DC 20460. Submissions

should bear the document control

number (OPPTS-41042; FRL-4923-2).

The public record supporting this

action, including comments, is available

for public inspection in Rm. B-607

NEM at the address noted above from 12

noon to 4 p.m., Monday through Friday

except legal holidays.

FOR FURTHER INFORMATION CONTACT:

Susan B. Hazen, Director,

Environmental Assistance Division

(7408), Office of Pollution Prevention

and Toxics, Environmental Protection

Agency, 401 M St., SW., Rm. E-543B,

Washington, DC 20460, (202) 554-1404,

TDD (202) 554-0551.

SUPPLEMENTARY INFORMATION: EPA has

received the TSCA Interagency Testing

Committee's Thirty-Fifth Report to the

Administrator.

I. Background

TSCA (Pub. L. 94-469, 90 Stat. 2003

et seq; 15 U.S.C. 2601 et seq.) authorizes

the Administrator of EPA to promulgate

regulations under section 4(a) requiring

testing of chemicals and chemical

groups in order to develop data relevant

to determining the risks that such

chemicals and chemical groups may

present to health or the environment.

Section 4(e) of TSCA established the

Interagency Testing Committee to

recommend chemicals and chemical

groups to the Administrator of EPA for

priority testing consideration. Section

4(e) directs the ITC to revise the TSCA

section 4(e) Priority Testing List at least

every 6 months. The most recent

revisions to this List are included in the

ITC's Thirty-Fifth Report. The Report

was received by the Administrator on

November 3, 1994, and is included in

this Notice. The Report designates a

group of 25 chemicals, and removes 110

of 123 previously recommended

chemicals from the TSCA section 4(e)

Priority Testing List.

II. Written and Oral Comments

EPA invites interested persons to

submit detailed comments on the ITC's

Report. All submissions should bear the

identifying docket number (OPPTS41042).

EPA invites interested persons to

submit detailed comments on the ITC's

new recommendations. The Agency is

interested in receiving information

concerning additional or ongoing health

and safety studies on the subject

chemicals as well as information

relating to the human and

environmental exposure to these

chemicals.

A notice will be published at a later

date in the Federal Register adding

certain of the substances recommended

in the ITC's Thirty-Fifth Report to the

TSCA section 8(d) Health and Safety

Data Reporting Rule (40 CFR part 716),

which requires the reporting of

unpublished health and safety studies

on the listed chemicals. That notice will

also add the chemicals to the TSCA

section 8(a) Preliminary Assessment

Information Rule (40 CFR part 712). The

section 8(a) rule requires the reporting

of production volume, use, exposure,

and release information on the listed

chemicals.

III. Status of List

The ITC's Thirty-Fifth Report notes

the designation of 25 chemicals and-the

removal of 110 chemicals from the

Priority Testing List. The current TSCA

section 4(e) Priority Testing List

contains 13 chemicals and 12 chemical

groups, with 3 chemical groups and 3

chemicals designated for testing.

IV Testing Consent Agreements

1. Solicitation of interested parties.

EPA's procedures for requiring the

testing of chemical substances under

section 4 of TSCA include the adoption

of enforceable consent agreements and

the promulgation of test rules. These

processes are found at 40 CFR 790.20.

EPA has on numerous occasions been

approached by chemical companies

interested in negotiating consent

agreements for testing ITC chemicals or

chemical groups. As a result of these

requests, EPA is now inviting persons

interested in participating in or

monitoring negotiations on the chemical

designated in the Thirty-Fifth ITC.

Report to notify EPA in writing. Those

who respond to this solicitation by the

deadline established in this notice will

have the status of "interested parties"

and will be afforded opportunities to

participate in the negotiation process.

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These "interested parties" willnot incur

any obligations by being designated

"interested parties."

2. Solicitation of testing proposals for

consent agreement negotiations. EPA is

also now soliciting testing proposals for

a consent agreement to perform dermal

absorption testing on the 25 chemicals

designated in the Thirty-Fifth Report.

While solicitation is separate from the

solicitation of interested parties made

for the 24 substances designated in the

Thirty-First ITC Report published May

5, 1993 (58 FR 26898), and the 34

substances designated in the ThirtySecond Report published July 16, 1993

(58 FR 38490), EPA expects that any

testing consent agreement adopted for

this effort, as well as the testing method

referenced, will be substantially similar.

(Note: Two of these chemicals were

removed in the Thirty-Fourth Report).

Following publication of thls notice,

manufacturers and/or processors have

60 days to develop and submit testing

proposals for any of the chemical

substances designated in the ThirtyFifth Report that they wish EPA to

consider as candidates for consent

agreement negotiations.

Federal scientists from a number of

the ITC's statutory and liaison

organizations, including the Consumer

Product Safety Commission,

Environmental Protection Agency, Food

and Drug Administration, National

Institute of Occupational Safety and

Health, and Occupational Safety and

Health Administration, have developed

a proposed test protocol that will

provide data needed by several U.S.

Government Organizations represented

on the ITC. This proposed protocol is

entitled "Protocol for in vitro

0 ercutaneous Absorption Studies" and

is available to the public through the

TSCA Nonconfidential Information

Center and the Environmental

Assistance Division listed above. This

document should be reviewed before

submitting any testing proposals in

response to this notice.

Comments on the proposed protocol

that were submitted in response to the

Thirty-First ITC Report (Docket OPPTS

41038) and the Thirty-Second ITC

Report (Docket OPPTS 41039) will be

incorporated in the docket for this

notice and need not be resubmitted.

For additional technical information

on this testing protocol contact Dr. John

D. Walker, Executive Director, TSCA

Interagency Testing Committee, (202)

260-1820.

All testing proposals submitted

should describe the testing to be

performed and explain any deviations

from the test protocol that are necessary

to assure the development of reliable

percutaneous absorption data.

EPA will review the submissions and

select the most promising submissions

as candidates for negotiation.

Submissions that fully address the ITC's

concerns will have a higher chance of

success than those that do not fully

address all data needs.

3. Negotiation of testing program and

development of a testing consent

agreement. EPA will follow the

negotiation procedures under 40 CFR

790.22, and to the extent feasible, the

timetable outlined in 40 CFR part 790,

appendix A to subpart B.

For additional information about

process or negotiations contact Frank

Kover, Chief, Chencal Testing and

Information Branch, (202) 260-8130.

Authority: 15 U.S.C. 2603.

Dated: December 20, 1994.

Charles M. Auer,

Director, Chemical Control Division, Office

of Pollution Prevention and Toxics.

Administrator, U.S. Environmental

Protection Agency

SUMMARY: This is the 35th Report of the

TSCA Interagency Testing Committee

(ITC) to the Administrator of the U.S.

Environmental Protection Agency

(EPA). In this Report, the ITC is revising

its TSCA section 4(e) Priority Testing

List by designating a group of 25

chemicals for dermal absorption testing

because they are of regulatory interest to

the Occupational Safety and Health

Administration (OSHA). The ITC is also

revising its List by removing

recommended chemicals, including 28

of 43 isocyanates, 27 of 89 aldehydes, 25

of 26 sulfones, 7 of 11 cyanoacrylates,

4 of 14 diaryl ethers and 19 of 35

chemicals originally recommended for

subchronic (90-day) toxicity testing.

1. Background

The TSCA Interagency Testing

Committee (ITC) was established by

section 4(e) of the Toxic Substances

Control Act (TSCA) "to make

recommendations to the-Administrator

respecting the chemical substances and

mixtures to which the Administrator

should give priority consideration for

the promulgation of a rule for testing

under section 4(a).... At least every 6

months.... the Committee shall make

such revisions in the List as it

determines to be necessary and to

transmit them to the Administrator

together with the Committee's reasons

for the revisions" (Public Law 94-469,

90 Stat. 2003 et seq., 15 U.S.C. 2601 et

seq.). Since its creation in 1976, the ITC

has submitted 34 semi-annual Reports

to the EPA Administrator transmitting

the Priority Testing List and its

revisions. These Reports have been

published in the Federal Register and

are available from the ITC. The ITC

meets monthly and produces its

revisions with the help of staff and

technical contract support provided by

EPA. ITC membership and support

personnel are listed at the end of this

Report.

Following receipt of the ITC's Report

and the addition of chemicals to the

Priority Testing List, the EPA's Office of

Pollution Prevention and Toxics adds

new chemicals from the List to TSCA

section 8(a) and8(d) rules that require

manufacturers, processors, and/or

distributors of these chemicals to submit

TSCA section 8(a) production and

exposure data and TSCA section 8(d)

health and safety studies, within 60

days of the rule's effective date. The

submissions are indexed and

maintained by EPA. The ITC reviews

the section 8(a) and 8(d) information

and other available data on chemicals

and chemical groups (e.g., TSCA section

8(e) "substantial risk" studies, "For

Your Information" (FYI) submissions to

EPA, and published papers) to

determine if revisions to the List are

necessary. Revisions can include

changing a recommendation to a

designation for action by the

Administrator within 12 months,

modifying the recommended testing, or

removing the chemical or chemical

group from the List.

Il. Revisions to the TSCA Section 4(e)

Priority Testing List

The ITC's revisions to its TSCA

Section 4(e) Priority Testing List are

summarized in Table 1.

TABLE 1.-CHEMICALS DESIGNATED

OR REMOVED FROM THE TSCA

SECTION 4(e) PRIORITY TESTING

LIST

Cherncal/Group Action Date

25 Chemicals

with insufficient

dermal absorption data.

28 Isocyanates ...

25 Suffones ........

Designate for

Dermal Absorption Testing

Remove Previously Recommended

Chemicals

Remove Previously Recommended

Chemicals

11/94

11/94

11/94

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TABLE 1 -CHEMICALS DESIGNATED.

OR REMOVED FROM THE TSCA

SECTION 4(e) PRIORITY TESTING

LIST-Continued

Chemical/Group Action Date

18 Chemricals Remove Pre- 11/94

with insufficient viously Recsubchronic (90- ommended

day) toxicity Chemicals

data.

27 Aldehydes ..... Remove Pre- .11/94

viously Recommended

Chemicals

7 Cyanoacrylates Remove Pre- 11/94

viously Recommended

Chemicals

4 Diaryl ethers .... Remove Pre- 11/94

viously Recommended

Chemicals

III. Rationale for the Revisions

A. ITC's Activities During this Reporting

Period

During the 6 months covered by this

Report, May through October 1994, the

ITC reviewed dermal absorption data for

63 chemicals with dermal LD5 0 values,

and 1989 production volumes greater

than I million pounds. The ITC also

reviewed the TSCA section 8(a) and

section 8(d) submissions and other

available data for 43 isocyanates that

were recommended in the ITC's 26th

Report (55 FR 23050, June 5, 1990) as

well as 26 sulfones and 35 chemicals

with insufficient subchronic (g0-day)

toxicity data that were recommended in

the ITC's 27th Report (56 FR 9534,

March 6, 1991). In addition, the ITC

rewiewed the production volume data

obtained under the 1990 TSCA

Inventory Update Rule and TSCA

section 8(a) Preliminary Assessment

Information Reporting rules for 89

aldehydes that were recommended in

the ITC's 27th Report, 11 cyanoacrylates

that were recommended in the ITC's

28th Report (56 FR 41212, August 19,

1991) and 14 diaryl ethers that were

recommended in the ITC's 29th Report

(56 FR 67424, December 30, 1991).

Based on these reviews, the ITC decided

which chemicals in these groups to

designate for testing, to retain on the

Priority Testing List or to remove from

the List.

B. Specific Rationales

1. Designated chemicals-a.

Chemicals with insufficient dermal

absorption data. OSHA previously

established Permissible Exposure Limits

(PELs) for chemical substances and

mixtures to 'limit workers! exposure to

industrial chemicals. In general, PELs

are based on inhalation of airborne

dusts and vapors. In those cases where

chemical absorption through the skin

could be harmful, the chemicals with

PELs are assigned skin notations. OSHA

needs quantitative measures of dermal

absorption to evaluate potential hazards

to workers.

In September 1991, OSHA nominated

chemical substances and mixtures with

PELs to the ITC to assess the availability

of dermal absorption data. OSHA

requested that ITC use its TSCA section.,

4(e) statutory authority to designate

chemicals with insufficient dermal

absorption data for priority testing

consideration. As described in previous

ITC reports, the chemicals were

organized into groups to facilitate

review. In its 31st report, the ITC

designated a group of 24 chemicals for

dermal absorption testing for which no dermal toxicity or absorption data could

be located in the publicly available

literature. In its 32nd report, the ITC

designated a group of 34 chemicals for

dermal absorption testing because

existing dermal toxicity and absorption

data were insufficient for OSHA's

needs. In the 34th report, the ITC

removed two of the previously

designated chemicals from the Priority

Testing List because dermal absorption

data to meet OSHA's needs were

obtained.

Over the past year, the ITC began to

review a group of 429 chemicals that

have rabbit dermal LDso values in

RTECS. Relevant information regarding

dermal absorption, production volume,

exposure and use, health effects and

physicochemical properties were

evaluated. The ITC reviewed 63 of these

chemicals, all of which had 1989

production volumes greater than 1

million pounds, and is designating 25

chemicals determined to have

insufficient dermal absorption data to

meet OSHA's needs in the following

Table 2. The ITC is continuing to review

the remaimng chemicals.

TABLE 2.-CHEMICALS WITH INSUFFICIENT DERMAL ABSORPTION DATA

THAT ARE BEING DESIGNATED FOR

DERMAL ABSORPTION TESTING

CAS No Chemical Name

75-05-8 .....

75-12-7 .....

75-35-4 .....

77-73-6 .....

78-59-1 .....

78-83-1 .....

78-87-5 ......

91-20-3 ......

Acetonitrile

Formamide

Vinylidene chlonde

Dicyclopentadiene

Isophorone

Isobutyl alcohol

Propylene dichlonde

Naphthalene

TABLE 2.---CHEMICALS WITH INSUFFICIENT DERMAL ABSORPTION DATA

THAT ARE BEING DESIGNATED FOR

DERMAL ABSORPTION TESTINGContinued

CAS No. Chemical Name

92-52-4 ..... Biphenyl

95-50-1 ...... o-Dichlorobenzene

96-18-4 ..... 1,2,3-Tnchloropropane

98--29-3 ..... t-Butylcatechol

99-08-1 ...... m-Nitrotoluene

99-99-0 .... p.Nitrotoluene

106-46-7 ... p-Dichlorobenzene

107-06-2 .... Ethylene dichloride

108-93-0 ... Cyclohexanol

108-94-1 ... Cyclohexanone

110-12-3 ... Methy soamyl ketone

120-80-9 ... Catechol

121-69-7 ... Dimethylaniline

123-42-2 ... Diacetone alcohol

127-19-5 .... Dimethyl acetamude

542-92-7 ... Cyclopentadiene

34590-94-8 Dipropylene glycol methyl ether

2. Removal of chemicals from the

Priority Testing Lst-a. Previously

recommended chemicals for which

production volume and exposure data

and health and safety studies have been

reviewed. For three previously

recommended chemical groups

(isocyanates, sulfones and chemicals

with insufficient subchromc (90-day)

toxicity data), the ITC reviewed the

1989 production volume data that were

submitted in response to EPA's

September 27 1990, TSCA section 8(a)

Partial Inventory UpdateRule (55 FR

39586). In addition, the ITC reviewed

the production and exposure data and"

health and safety studies that were

submitted, in response to EPA's

September 28, 1990, TSCA section 8(a)

Preliminary Assessment Information

Reporting (PAIR) Rule and TSCA

section 8(d) Health and Safety Data

Reporting Rule for isocyanates (55 FR

39586) and EPA's August 29, 1991,

PAIR and Health and Safety Data

Reporting Rule for sulfones and

chemicals with insufficient subchronic

(90-day) toxicity data (56 FR 42688). For

these chemical groups, the ITC also

requested, received and reviewed, use

and exposure data from several

companies, studies that have been

published since the ITC recommended

these chemicals for testing, TSCA

section 8(e) and FYI studies,

unpublished data from tests conducted

by the U.S. Government organizations

represented on the ITC and data from

the 1981-1983 National Occupational

Exposure Survey (NOES). After

reviewing these data and considering

the data needs of U.S. Government

organizations represented on the ITC,

the ITC decided which chemicals in

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these groups should be removed from

the Priority Testing List. The chemicals

in these groups that were removed from

the List and the rationales for removing

them are described below.

.1. Isocyanates. The ITC transmitted its

26th Report to the EPA Administrator

on May 8, 1990, and recommended a

group of 43 isocyanates for physical and

chemical property testing in response to

a nomination from the EPA to support

its TSCA New Chemicals Program. (55

FR 23050, June 5, 1990). The ITC is

removing 27 isocyanates from the

Priority Testing List because annual

production volumes were less than 1

million pounds or there appeared to be

low potential for exposure. The ITC is

also removing methyl isocyanate from

the List because its physical and

chemical properties. appear to be well

characterized. The 28 isocyanates that

ITC is removing from the List are

included in the following Table 3.

TABLE 3.-ISOCYANATES REMOVED

FROM THE PRIORITY TESTING LIST

CAS No. Chemical Name

91-97-4 .....

100-28-7 ....

104-49-4 ...

109-90-0 ....

110-78-1 ....

112-96-9 ...

123-61-5 ...

614-68-6 ...

4,4'-Diisocyanato-3,3'-

dimethylbiphenyl

p-Nitrophenyl isocyanate

p-Phenylene diisocyanate

Ethyl isocyanate

n-Propyl isocyanate

Octadecyl isocyanate

1,3-Diisocyanatobenzene

1-Isocyanato-2-methylbenzene

TABLE 3.-ISOCYANATES REMOVED

FROM THE PRIORITY TESTING LISTContinued

CAS No. Chemical Name

622-58-2 ... 1 -Isocyanato-4-methylbenzene

624-83-9 ... Methyl isocyanate

1476-23-9 3-isocyanato-1 -propene

2422-91-5 1,1' 1"-Methylidynetns(4-

isocyanatobenzene)

2493-02-9 1 -Bromo-4-isocyanatobenzene

2909-38-8 1 -Chloro-3-isocyanatobenzene

2949-22-6 Ethyl isocyanatoacetate

4151-5 ....... 1-3-Tris(4-isocyanatophenyl)

thiophosphate

10031-75-1 Diphenylmethylene

diisocyanate

15646-96-5 1,6-Diisocyanato-2,4,4-

trimethylhexane

16938-22-0 1,6-Diisocyanato-2,2,4-

tnmethylhexane

25854-16-4 Bis(isocyanatomethyl)benzene

26603-40-7 1,3,5-Tris(3-

isocyanatomethylphenyl)-

1,3,5-triazine2,4,6(1H,3H,5H)-trone

26747-90-0 Toluene diisocyanate dimer

28178-42-9 2,6-Diisopropylphenyl

isocyanate

28556-81-2 2-socyanato-1,3-

dimethylbenzene

30674-80-7 2-Isocyanatoethyl methacrylate

34893-92-0 3,5-Dichlorophenyl isocyanate

68239-06-5 2-Heptyl-3,4-bis(9-

isocyanatononyl)-l -

pentylcyclohexane 73597-26-9 Isophorone diisocyanate,

hydroxyethyl methacrylate

adduct

2. Sulfones. In its 27th Report, the ITC

recommended a group of 26 sulfones for

physical and chemical property testing

to estimate whether occupational

exposures or environmental releases

were likely to occur (56 FR 9534, March

6, 1991). This recommendation was

based on the results of the ITC's 6th

Scoring Exercise and thieuse of the

ITC's Substructure-based Computerized

Chemical Selection Expert System

(SuCCSES) to identify chemical groups

with common chemical substructures,

common exposure or adverse effects

potentials and common data

insufficiencies. The Scoring Exercise

and SuCCSES have been previously

described by Walker, and Brink (Ref. 1)

and Walker (Refs. 2 and 3). SuCCSES

was used to identify sulfones with

insufficient physical/chemical

properties. Based on a review of the data

and other considerations, the ITC is

removing 25 sulfones from the Priority

Testing List that are listed in the

following Table 4.

TABLE 4.--.SULFONES REMOVED FROM THE PRIORITY TESTING LIST

Chemical Name

Sul/ones removed because there appeared to be low exposure potential based on annual production volume and NOES data:

67-71-0 ................................................................................................ 80-08-0 ................................................................................................. 98-30-6 ................................................................................................

127-63-9 ..............................................................................................

2580-77-0 ............................................................................................ 3278-22-6 ............................................................................................

5246-57-1 ............................................................................................

16588-67-3 ..........................................................................................

17557-67-4 ..........................................................................................

17601-96-6 .......................................................................................... 17688-68-5 .......................................................................................... 17741-62-7 ..........................................................................................

20018-09-1 ..........................................................................................

26750-5-5 ..........................................................................................

36724-43-3 ..........................................................................................

41123-59-5 .......................................................................................... 41123-69-7 .......................................................................................... 41687-30-3 ..........................................................................................

52218-35-6 ..........................................................................................

53061-10-2 .......................................................................................... 63134-33-8 ..........................................................................................

Sulfones removed beF-ause testing recommendations are currently a

lower priority than others:

77-79-2 ................................................................................................ 80-09-1 ................................................................................................

Dimethylsulfone

4,4'-Diaminodiphenyl sulfone

2-Amino-4-(methylsulfonyl)pheno

Diphenylsulfone

2,2'-Sulfonyl bisethanol

1,1 '-[Methylene bis(sulfonyl)]bisethene

2-[(3-Aminophenyl)sulfonyl]-ethanol

3-[N-Ethyl-4-[[6-(methylsulfonyl)-2-benzothiazolyl]azo]-m-toludino]-propionitrile

6-Methylsulfonyl)-2-benzothiazolamine

2-Amino-4-[(2-hydroxyethyl)sulfonyllphenol

4-Phenylthiomorpholine, 1,1-dioxide

4-[4-[(2,6-Dichloro-4-nitrophenyl)azo]phenyl]-thiomorpholine, 1,1

dioxide1-(Diiodomethyl)sulfonyl-4-methyl benzene

1,1 '-[Oxybis(methylenesulfonyl)] bisethene

2,2'-[Oxybis(methylenesulfonyl)] bisethanol

1,1'-[Methylenebis(sulfonyl)] bis-2-chloroethane

2,2'-[Methylenebis(sulfonyl)] bisethanol

2-[(3-Nitrophenyl)sulfonyl] ethanol

2-[(6-Amino-2-naphthalenyl)sulfonyl ethanol

1,1 '-[Oxybis(methylenesulfonyl) bis-2-chloroethane

4-[[4-(Phenylmethoxy)phenyl]-sulfonyl] phenol

Sulfolene

Bisphenol S

CAS No.

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TABLE 4.- SULFONES REMOVED FROM THE PRIORITY TESTING LiST-Continued

CAS No. Chemical Name

126-33-0 .............................................................................................. Suffolane

18760-44-6 .............................................................................................. 3-(Decyloxy)tetrahydrothiophene 1,1-dioxide

3. Chemicals previously

recommended fer subchronic (90-day)

toxicity testing. On May 17 1987 the

ITC convened a public meeting to

discuss the results of the its 6th Scoring

Exercise, development of SuCCSES and

a list of 166 substantially produced

chemicals (i.e., chemicals with 1985

production volumes > 1 million

pounds) that were coded in SuCCSES

for exposure and adverse effects

potentials. Based on a review of

available data, the ITC recommended a

group of 35 chemicals in its 27th Report

that did not have 90-day subchromc

toxicity test data (56 FR 9534, March 6,

1991). Based on a review of the data

submitted to EPA and other

considerations, the ITC is removing 18

chemicals from the Priority Testing List

that are listed in the following Table 5.

TABLE 5.-CHEMICALS PREVIOUSLY RECOMMENDED FOR SUBCHRONIC (90-DAY) TOXICITY TESTING REMOVED FROMTHE

PRIORITY TESTING LIST

CAS No. Chemical Name

Chemicals removed because there appeared to be low exposure po- tential based on annual production volume and use data:

84-51-5 ................................................................................................

87-02-5 ................................................................................................ 95-32-9 ................................................................................................

98-48--6 ................................................................................................ 99-63-8 ................................................................................................ 100-20-9 .............................................................................................. 106-31-0 .............................................................................................. 116-81-4 .............................................................................................. 123-62-6 ..............................................................................................

616-21-7 .............................................................................................. 760-23-6 .............................................................................................. 1111-78-0 ............................................................................................ Chemicals removed because Screening Information Data Set dossiers

have been developed and the need for 90-day subchronic toxicity

tests will be considered by representatives from OECD countries that

review these dossiers:

92-70-6 ................................................................................................ 102-01-2 ..............................................................................................

Chemicals removed because subchronic (90-day) toxicity testing rec

ommendations are currently a lower priority than other:

123-54-6 ..............................................................................................

311-89-7 ..............................................................................................

355-42-0 .............................................................................................. 1047-16-1 .......................................

2-Ethylanthraquinone

7-Amino-4-hydroxy-2-naphthalenesulfonic acid

2-(4-Morpholinyldithio)-benzothiazole

1,3-Benzenedisulfonic Acid

Isophthaloyl chloride

Terephthaloyl chloride

Butyric anhydride

Bromamine acid

Propanoic anhydride

1,2-Dichlorobutane

3,4-Dichlorobutene

Ammonium carbamate

3-Hydroxy-2-naphthoic acid

Acetoacetanilide

2,4-Pentanedione

Perfluorotributylamine

Perfluoro-N-hexane

Quinacridone

b. Previously recommended chemicals

for which production volume data have

been reviewed. For three previously

recommended chemical groups

(aldehydes, cyanoacrylates and diaryl

ethers), the ITC reviewed the 1989

production volume data that were

submitted in response to EPA's

September 27 1990, TSCA section 8(a)

Partial Inventory Update Rule (55 FR

39586). In addition, the ITC reviewed

the production and exposure data that

were submitted in response to EPA's

August 29, 1991 PAIR rule for

aldehydes (56 FR 42688), to EPA's

December 27 1993 PAIR rule for

cyanoacrylates (58 FR 68317) and to

EPA's March 12, 1993 PAIR rule for

diaryl ethers (58 FR 13556). After

reviewing these data, the ITC decided to

remove chemicals in these groups from

the Priority Testing List that had

production volumes less than 10,000

pounds per year.

1. Aldehydes. The ITC submitted its

27th Report to the EPA Admimstrator

on November 19, 1990, and

recommended a group of 89 aldehydes

for aquatic toxicity testing m response

to a nomination from the EPA to

support its TSCA New Chemicals

Program (56 FR 9534, March 6, 1991).

Based on a review of production volume

data, the ITC is removing 27 aldehydes

from the Priority Testing List.'These

aldehydes are listed im the following

Table 6.

TABLE 6.-ALDEHYDES REMOVED FROM THE PRIORITY. TESTING LIST

CAS No. 1-

66-77-3 .................................................................................................... 78-85-3 ....................................................................................................

93-53-8 ....................................................................................................

95-01-2 ....................................................................................................

97-51-8 ....................................................................................................

Chemical Name

1 -Naphthalenecarboxaldehyde

2-Methyl-2-Propenal

cMethyl-benzeneaoetaldehyde

2,4-Dihydroxybenzaldehyde

2-Hydroxy-5-nitrobenzaldehyde

67600

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Federil Register 'I W1. 59, No. 249 / Thursday December 29, 1994 :/- Notices

TABLE 6.-ALDEHYDES; REMOVED FROM THEPRIORITY TESTING' LwS--Continued

CAS No.

98-03-3 ........................................... 99-72-9 ....................................................................................................

106-2f6-3 ..................................................................................................

106-72-9 .................................................................................................

123-08-0 .................................................................................................

135-02-4 ..................................................................................................

141-27-5 ............................................................................................

143-14-6 ..................................................................................................

455-19-6 .................................................................................................

505-57-7 ..................................................................................................

552-89-6 ..................................................................................................

1121-60-4 ................................................................................................

1200-14-2 ................................................................................................

1334-78-7 ................................................................................................

1423-46-7 ..........................................................................................

5435-64-3 ................................................................................................

5780-07-4 ................................................................................................

5949-05-3 ................................................................................................

5988-91-0 ................................................................................................

10031-82-0 ..............................................................................................

28602-27-9 ........................................

37677-14:-8 .......................................................................................

+

Chemical Name

2-Thiophenecarboxaldehyde

4-Methylbenzeneacetaldehyde

3,7-Dimethyl-2,6-Octadienal, (Z)-

2,6-Dimethyl-5-heptenal

4-Hydroxybenzaldehyde

2-Methoxybenzaldehyde 3,7-Dimethyl-_2,6-octadienal, '(E)-

9-Undecenal

4-(Trfluoromethyl)benzaldehyde

2-Hexenal

2-Nitrobenzaldehyde

2-Pyndinecarboxaldehyde

4-Butylbenzaldehyde

Methylbenzaldehyde

2,4,6-Trimethyl-3-cyclohexene i-carboxaldehyde

3,5,5-Trimethylhexanal

7-Methoxy-1 3-benzodioxole-5-carboxaldehyde

3,7-Dimethyl-6-Octenal, (S)-

3,7-dimethyloctanal

4-Ethoxybenzaldehyde

(Dimethylamino)benzaldehyde

4-4-Methyl-3-pentenyl)-3-cycldhexene-l-carboxaldehyde

2. Cyanoacrylates. In -its 28th Report, the ITC recommended a group of 11 cyanoacrylates for physical and chemical

property testing. The ITC's recommendation was based on concerns and uncertainties rdlated ,to production and use,

potential exposures and -releases from production, processing and use (56 FR 41212, August 19, 1991). -Based on a

review of production volume data, the ITC is removig, 7 cyanoacrylates fromthe Priority Testing List. These cyanoacrylates

are listed in the following Table 7

TABLE'7 -CYANOACRYLATES REMOVED FROM THE PRIORITY TESTING LIST

GAS No. Chemical Name

1069-55-2 ........ 2-Propenoic acid, 2-cyano- isobutyl ester (isobutyl cyanoacrylate)

6606-65-1 ........ 2-Propenoic acid, 2-cyano- butyl ester (butyl cyanoacrylate)

7324-02-9 ........ 2-Propenoic acid, 2-cyano- 2-propenyl ester (allyl cyanoacrylate)

10586-17-1 ...... 2-Propenoic acid, 2-cyano- 1-methylethyl ester (isopropyl cyanoacrylate)

21982-43-4 ...... 2-Propenoic acid, 2-cyano- ethoxy ethyl ester (ethoxy ethyl cyanoacrylate)

23023-91-8 ...... 2-Propenoic acid, 2-cyano- 2,2,2-tdfluomethyl ester (2,2,2-trifluoromethyl cyanoacrylate)

27B16-23-5 ...... I 2-Propenoic acid, 2-cyano- methyoxy ethyl ester (methoxy ethyl cyanoacrylate)

3. Diaryl ethers. In its 29th Report, the ecological effects screening tests (56 FR Exercise. Based on a review of

ITC recommended a group of 14.alkyl, 67424, December 30, 1991). This production volume data, the ITCis

bromo, chloro, or hydroxy-methyl diaryl recommendation was based on an removing 4.diaryl ethers from the

ethers for physical chemical property analysis of data in SuCCSES that was Priority Testing List. These,diaryl ethers

biodegradation rate, health effects and compiled during the ITC's 6th Scoring are listed in the following Table 8.

TABLE 8.-DIARYL ETHERS REMOVED FROM THE PRIORITY TESTING LIST

CAS No. Cherical Name

3061-36-7 ............................................................................................................................. 1 ;4-Diphenoxybenzene

50789-44-1 ........................................................................................................................... 3-Phenoxybenzene m ethanol acetate

61702-8 8-3 ........................................................................................................................... 1,1'-O xybis(1,1,3,3-tetram ethylbutyl)benzene

69834-1 19- 1 ........................................................................................................................... 1'-O xybisdodecylbenzene

References

(1) Walker, J.D. and Brink, R.H. "New CostEffective, Computerized Approaches to

Selecting Chemicals for Priority Testing

Consideration, In: Aquatic Toxiology and

Environmental Fate: Eleventh Volume,

ASTM STP 1007 G. W. Suter, II and M.A.

Lewis, Eds., American Society for Testing

and Materials, Philadelphia, PA. pp. 507-536

-(1989).,

(2) Walker, J.D. "Chemical Selection by the

TSCA Interagency Testing Committee: Use of

Computerized Substructure Searching to

Identify Chemical Groups for Health Effects,

Chemical Fate and Ecological Effects

Testing, Science of the Total Environment:

Vol. 109/110, pp. 691-700 (1991).

(3) Walker, J.D. "The TSCA Interagency

Testing Committee, 1977 to 1992: Creation,

Structure, Functions and Contributions, In:

Environmental Toxicology and Risk

Assessment: Second Volume, ASTM STP

1216, J.W. Gorsuch, F.J. Dwyer, C.G. Ingersoll

and T.W. LaPoint, Eds., American Society for

Testing and Materials, Philadelphia, PA, pp.

451-509 (1993).

IV The TSCA Section 4(e) Revised

Priority Testing List

The revised TSCA section 4(e)

Priority Testing List follows.

67601

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Federal Register / Vol. 59, No. 249 / Thursday, December 29, 1994 / Notices

I I

..... November 1988

..... I November 1988

May 1990

November 1990

November 1990

November 1990

May 1991

May 1991

May 1991

May 1991

November 1991

May 1992

May 1992

January 1993

January 1993

January 1993

May 1993

May 1994

May 1994

May 1994

November 1994

THE TSCA SECTION 4(E) PRIORITY TESTING LIST (NOVEMBER 1994)

Chemical/Group

Butyraldehyde

Tetrakis(2-chloroethyl)ethylene diphosphate

Tris(1,3-dichloro-2-propyl) phosphate

Tns(1-chloro-2-propyl) phosphate

Tris(2-chloro- 1-propyl) phosphate

Tris(2-chloroethyl)-phosphate

15 Isocyanates

62 Aldehydes

Sulfonyl bis(4-chlorobenzene)

17 Chemicals with insufficient subchronic (90-day) toxicity data

Acetone

Thiophenol

m-Dinitrobenzene

14 Cyanoacrylates

10 Alkyl- bromo- chloro- hydroxymethyl diaryl ethers

56 Siloxanes

25 Chloroalkyl phosphates

24 Chemicals with no dermal toxicity data

13 Propylene glycol ethers and esters -

32 Methyl ethylene glycol ethers and esters

32 Chemicals with insufficient dermal absorption data.

White phosphorus

Ethyl ter-butyl ether

Tert-amyl methyl ether

25 Chemicals with insufficient dermal absorption data

Action

Recommended

Recommended

ignate

Recommended

ignate

Recommended

ignate

Recommended

Recommended

Designated

Designated

Recommended

Recommended

Recommended

Recommended

Recommended

Designated

Recommended

Recommended

* Designated

Designated

Recommended

Recommended

Designated

with intent-to-desintent-to-desintent-to-desTSCA Interagency Testing Committee

Statutory Organizations and Their

Representatives

Council on Environmental Quality

Elisabeth Blaug, Member

Department of Commerce

Edward White, Member.

Willie E. May, Alternate

Environmental Protection Agency

David R. Williams, Member

Lois Dicker, Alternate

National Cancer Institute

Harry Seigried, Member

Richard Adamson, Alternate

National Institute of Environmental Health

Sciences

Errol Zeiger, Member, Vice Chair

H.B. Matthews, Alternate

National Institute for Occupational Safety

and Health

Henryka Nagy, Member

David A. Dankovic, Alternate

National Science Foundation

Linda Duguay, Member

Occupational Safety and Health

Administration

Christine Whittaker, Member, Chair

Liaison Organizations and Their

Representatives

Agency for Toxic Substances and Disease

Registry

William Cibulas, Member

Consumer Product Safety Commission

Val Schaeffer, Member

Lakshmi C. Mishra, Alternate

Department of Agriculture

Donald Derr, Member

Clifford Rice, Alternate

Department of Defense

David A. Macys, Member

James N. McDougal, Alternate

Department of the Interior

Barnett A. Rattner, Member

Food and Drug Administration

Edwin J. Matthews, Member

Ralu Kammula, Alternate

National Library of Medicine

Vera Hudson, Member

National Toxicology Program

Victor A. Fung, Member

Counsel

Mary Ellen Levine, Office of General

Counsel, EPA

Technical Support Contractor

Syracuse Research Corporation

ITC Staff

John D. Walker, Executive Director

Norma S.L. Williams, Executive

Assistant, TSCA Interagency Testing

Committee U.S. EPA/OPPT-(MC 7401) 401 M

Street, S.W. Washington, D.C. 20460 Phone

(202) 260-1825 Fax (202) 260-7895 Internet

walker.)ohnd@epamail.epa.gov

(FR Doc. 94-32117 Filed 12-28-94; 8:45 am]

BILLING CODE 6560-60-F

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67602

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