UNITED STATES ENVIRONMENTAL PROTECTION AGENCY 

WASHINGTON, D.C. 20460 

MEMORANDUM 

DATE: 05-NOV-2015 

OFFICE OF 

CHEMICAL SAFETY AND 

POLLUTION PREVENTION 

SUBJECT: Saflufenacil. Acute and Chronic Aggregate Dietary (Food and Drinking Water) 

Exposure and Risk Assessment for Tolerances for Residues in/on Pomegranate. 

PC Code: 118203 DP Barcode: D426932 

Decision No.: 493885 Registration No.: 7969-276 

Petition No.: 4F8305 Regulatory Action: Sec. 3 Registration 

Risk Assessment Type: Dietary CaseNo.: NA 

TXRNo.: NA CAS No.: 372137-35-4 

MRIDNo.: NA 40 CFR: §180.649 

FROM: George F. Kramer, Ph.D., Senior Chemist ~ ~'2»~ :a 

Risk Assessment Branch 1 (RA~ )/Hea th Effects Division (HED; 7509P) r) I I I} 

THROUGH: William Cutchin, Chemist ::ZA~ l~~ Kristin 

Dietary 

Rury, 

Exposure 

Biologist 

Science 

¥..-Advi~rrCouncil ~ (DESAC) 

HED (7509P) 

and 

RABI

Charles 

, HED 

W. Smith 

(7509P) 

111, Branch Chief ~ 

TO: George F. Kramer, Ph.D., Risk Assessor 

RAB 1/HED (7509P) 

and 

Kathryn Montague/Bethany Benbow, PM Team 23 

Registration Division (RD) (7505P) 

Executive Summary 

Acute and chronic dietary-exposure and risk assessments were conducted using the Dietary 

Exposure Evaluation Model - Food Consumption Intake Database (DEEM-FCID, ver. 3.1 6) 

which incorporates consun1ption data from United States Department of Agriculture (USDA) 

National Health and Nutrition Examination Survey, What We Eat in America, 

(NHANES/WWEIA; 2003-2008). These analyses were performed to support tolerance petitions 

for residues in/on pomegranate. This memorandum was reviewed by two peer reviewers of the 

DESAC, per DESAC SOP 2012.1. 

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Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

Acute Dietary (Food and Drinking Water) Exposure Results and Characterization 

The unrefined acute analysis assumed I 00% crop treated (CT), DEEM 7 .8 1 default concentration 

factors, and tolerance-level residues for all commodities [except for cottonseed; sunflower 

subgroup 20B; soybean, seed; vegetable, legume, subgroup 6C, pea and bean (except soybean); 

and rapeseed subgroup 20A - see Section II for more details]. The drinking water estimate from 

the proposed U.S. use was incorporated directly into the dietary assessment using the peak 

concentration for surface water generated by Tier l Rice modeling. The acute dietary risk 

estimates (food + water) at the 95th percentile are <1% of the acute population-adjusted dose 

(aPAD) for the general U.S. population and <1% of the aPAD for the most highly exposed 

population subgroup (all infants (<I-year old)). and are thus below HED's level of concern 

(<100% aPAD). 

Chronic Dietary (Food and Drinking Water) Exposure Results and Characterization 

The unrefined chronic analysis assumed 100% CT, DEEM 7.81 default concentration factors, 

and tolerance-level residues for all commodities [except for cottonseed; sunflower subgroup 

20B; soybean, seed; vegetable, legume, subgroup 6C, pea and bean (except soybean); and 

rapeseed subgroup 20A - see Section II for more details]. The drinking water estimate from the 

proposed U.S. use was incorporated directly into the dietary assessment using the average 

concentration for surface water generated by Tier I Rice modeling. The chronic dietary risk 

estimates (food + water) are 9.2% of the chronic population-adjusted dose ( cP AD) for the 

general U.S. population and 20% of the cPAD for the most highly exposed population subgroup 

(aJI infants (< I-year old)) and are thus below HED's level of concern (<100% cPAD). 

Cancer Dietary (Food and Drinking Water) Exposure Results and Characterization 

Saflufenacil is classified as "not likely carcinogenic to humans." Therefore, cancer risk is not a 

concern for this chemical. 

I. Introduction 

Dietary risk assessment incorporates both exposure and toxicity of a given pesticide. For acute 

and chronic assessments, the risk is expressed as a percentage of a maximum acceptable dose 

(i.e., the dose which HED has concluded will result in no unreasonable adverse health effects). 

This dose is referred to as the PAD. The PAD is equivalent to point of departure (POD, noobserved adverse-effect level (NOA.EL), lowest-observed adverse-effect level (LOA.EL), i.e.) 

divided by the required uncertainty or safety factors. 

For acute and non-cancer chronic exposures, HED is concerned when estimated dietary risk 

exceeds 100% of the PAD. References which discuss the acute and chronic risk assessments in 

more detail are available on the EPNpesticides web site: "Available Information on Assessing 

Exposure from Pesticides, A User's Guide," 2 1-JUN-2000; or see SOP 99.6 (20-AUG-1999). 

The most recent dietary exposure risk assessment for saflufenacil was conducted by G. Kramer 

(Memo, 24-JUN-2014, 0 418585). 

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Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

II. Residue Information 

Saflufenacil Proposed and Registered Uses: 

Saflufenacil is currently registered for use on alfalfa; legume vegetables (Crop Group 06); the 

foliage of legume vegetables (Crop Group 07); citrus fruit (Crop Group 1 O); pome fruit (Crop 

Group 11); stone fruit (Crop Group 12); tree nuts (Crop Group 14); cereal grains (Crop Group 

15); the forage, fodder, and straw of cereal grains (Crop Group 16); cotton; grass (Crop Group 

17); olives; and sunflower. BASF has submitted a proposal for a new use of Treevix® Powered 

by Kixor® Herbicide (EPA Reg. No. 7969-276) to the base of pomegranate trees. 

Residues of Concern: The previously submitted metabolism data for com, soybean, and tomato 

were adequate to elucidate the nature of the residue in plants resulting from pre-plant/preemergence application. The HED Residues of Concern Knowledgebase Subcommittee 

(ROCKS) detennined that residues of concern for the tolerance expression and risk assessment 

consist of saflufenacil, M800Hl 1, and M800H35 (Memo, B. Daiss, 06-JAN-2009; D359645). 

This conclusion was translated to perennial crops (i.e., tree fruits and tree nuts) where 

saflufenacil application is directed to the weeds on the orchard floor (Memo, G. Kramer, 22-

JUL-2009; D349938). As the proposed use on pomegranate is also directed to weeds at the base 

of the plants, HED concludes that the residues of concern for the tolerance expression and risk 

assessment also consist of saflufenacil, M800Hl 1, and M800H35 for this crop. 

The nature of the residue in livestock is adequately understood based on acceptable metabolism 

studies conducted on lactating goats and laying hens. There are no livestock feedstuffs 

associated with the proposed use; therefore, no changes in the existing tolerances for livestock 

commodities are needed. 

Table 1. Summary of Metabolites and Degradates to be Included in the Risk Assessment. 

Matrix Residues Included in Risk Residues Included in 

Assessment Tolerance Expression 

Primary Crops (preplant Satlufenacil + M800H 11 , Satlufenacil + M800H I I, 

application)* M800H35 M800H35 

Plants Primary Crops (foliar Satlufenacil + M800H 11 , 

application) M800H02, M800H35 

Rotational Crops Satlufenacil + M800H 11 , 

M800H35 

Livestock 

Ruminants 

Poultry 

Saflufenacil Saflufenacil 

Saflufenacil + M800HO I, 

Drinking Water M800H02, M800H07, M800H08, Not Applicable 

M800H 15, M800H22, Product 8 

* Plus post-emergence foliar application to cereal grains and grasses and to weeds in fruit/nut orchards/groves. 

Established Tolerances (40 CFR §180.649): Permanent tolerances are established for 

"satlufenacil, including its metabolites and degradates, in or on the commodities in the table 

below. Compliance with the tolerance levels specified below is to be determined by measuring 

only the sum of saflufenacil, 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-

1 (2H)-pyrimidinyl]-4-tluoro-N-[[methyl(l-methylethyl)amino ]sulfonyl]benzamide, and its 

metabolites N-[2-chloro-5-(2,6-dioxo-4-(tritluoromethyl)-3,6-dihydro-l (2/-1)-pyrimidinyl)-4-

fluorobenzoyl]-N-isopropylsulfamide and N-[ 4-chloro-2-fluoro-5-( { [(isopropylamino )sulfonyl] 

Page 3 of20 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

amino }carbonyl)phenyl]urea, calculated as the stoichiometric equivalent of saflufenacil" under 

40 CFR § 180.649(a)( 1) for residues on a variety of crops, including but not limited to citrus fruit 

(Crop Group 10), pome fruit (Crop Group l l ), stone fruit (Crop Group 12), grapes, tree nuts 

(Crop Group 14 ), legume vegetables (crop group 06), the foliage of legume vegetables (crop 

group 07), cereal grains (crop group 15), forage, fodder, and straw of cereal grains (crop group 

16), cottonseed (subgroup 20C), rapeseed (subgroup 20A), sunflower (subgroup 20B), coffee, 

banana, and mango. Additionally, permanent tolerances are established for "saflufenacil, 

including its metabolites and degradates, in or on the commodities in the table below. 

Compliance with the tolerance levels specified below is to be determined by measuring only 

saflufenacil, 2-chloro-5-[3,6-dihydro-3-methyl-2,6-dioxo-4-(trifluoromethyl)-l (2H)-

pyrimidinyl]-4-fluoro-N-[[ methyl(l-methylethyl)amino ]sulfonyl]benzamide" under 40 CFR 

§ l 80.649(a)(2) for residues on livestock commodities. 

Recommended Tolerances: Based on the residue chemistry data submitted with the current 

petitions, HED recommended for establishment of the following tolerances (G. Kramer, 05-

NOV-2015; D422467): 

Table 2. Tolerance Summary for Saflufenacil. 

Commodity I Recommended Tolerance (oom) 

40 CFR §180.649(a)(I) 

Pomej?,ranate I 0.03 

Residue Data used for Acute and Chronic Assessments: 

The acute and chronic assessments were based on the assumption of tolerance-level residues for 

all commodities, except for cottonseed; sunflower subgroup 20B; soybean, seed; vegetable, 

legume, subgroup 6C, pea and bean (except soybean); and rapeseed subgroup 20A. For these 

crops, residues were also based on the recommended tolerances; however, a correction factor 

was applied to the tolerance level to account for the M800H02 metabolite included in the risk 

assessment as a result of preharvest uses. The additional metabolite, M800H02, was observed in 

the metabolism studies of preharvest-treated soybean seed, comprising 26.3% of the total 

radioactive residues (G. Kramer, 24-MAR-2011; DP# 381129). Since the toxicity of the 

M800H02 is expected to be comparable to that of the parent compound, it was included in the 

risk assessment for preharvest uses, but not in the tolerance expression. To account for this 

additional toxicity exposure, the recommended tolerance level was multiplied by a correction 

factor of 1.7X, where 1.7 =(Metabolites in Risk Assessment)/(Metabolites in Tolerance 

Expression). 

1.7 = (Saflufenacil + M800H 11 + M800H02 + M800H35)/(Saf1ufenacil + M800H 11 + M800H35) = 

(26. 1% + 10.9% + 26.3% + 0%)/(26.1% + 10.9% + 0%) 

Therefore, in the acute and chronic assessments, a residue of 0.34 ppm was used for cottonseed; 

a residue of 1. 7 ppm was used for sunflower subgroup 20B; a residue of 0.17 ppm was used for 

soybean, seed; a residue of 0.51 ppm was used for vegetable, legume, subgroup 6C, pea and bean 

(except soybean); and a residue of 0.76 ppm was used for rapeseed subgroup 20A (see Table 3). 

Page 4 of20 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

Table 3. Corrected Residues Used in the Chronic Assessment. 

Crop Group and/or Commodity Tolerance (oom) Corrected Residue Used in Dietary Assessments1 

Cottonseed Subgroup 20C 0.20 0.34 

Sunflower Subgroup 20B 1.0 1.7 

Soybean, seed 0.10 0.17 

Vegetable, Legume, Subgroup 6C, 0.30 0.51 

pea and bean (except soybean) 

Rapeseed Subgroup 20A 0.45 0.76 1 Tolerance level residues were corrected to account for the addition of the M800H02 metabolite which was observed m the 

metabolism studies ofpreharvest-treated soybean seed. The recommended tolerance level was multiplied by a correction factor 

of I. 7X, where 1.7 = (Metabolites in Risk Assessmcnt)/(Mctabolitcs in Tolerance Expression). 

Processing Factors: DEEM 7.81 default processing factors were used for all processed 

commodities (where provided). 

III. Percent Crop Treated Information 

The acute and chronic assessments were based on the assumption of 100% CT for all 

commodities. 

IV. Drinking Water Data 

The Estimated Drinking Water Concentrations (EDWCs) used in the dietary exposure risk 

assessment were provided by the Environmental Fate and Effects Division (EFED) in a 

memorandum dated 12-MAR-2014 (Memo, M. Ruhman; DP# 414485). Water residues were 

incorporated directly into the DEEM-FCID into the food categories "water, direct, all sources" 

and "water, indirect, all sources." 

Screening EDWCs (Table 4) of saflufenacil were generated for surface water by Tier I Rice 

modeling. Modeled application rates represent the maximum use patterns for dry-seeded rice: 

the I st application at planting, the second application 14 days after planting, and flooding at 45 

days after planting. Remaining model input parameters were chosen according to current 

guidance (USEPA, 2002). EDWCs reflect exposure to saflufenacil and all degradates of concern 

in drinking water (Table 1). 

Table 4. Tiered EDWCs for Proposed Saflufenacil Uses. 

1-in-10-year Peak Exposure l-in-10-year Annual Mean 

Source (Tier: Model) (ppb) Exposure (ppb) 

Surface water (Tier I: Rice Model) 133 120 

(used in acute analysis) (used in chronic analysis) 

Ground water (Tier 11: PRZM GW) 69.2 5 1.5 

V. DEEM-FCID Program and Consumption Information 

Saflufenacil acute and chronic dietary exposure assessments were conducted using the DEEMFCID, Version 3. 16, which incorporates 2003-2008 consumption data from USDA's 

NHANES/WWEIA. The data are based on the reported consumption of more than 20,000 

individuals over two non-consecutive survey days. Foods "as consumed" (e.g., apple pie) are 

linked to EPA-defined food commodities (e.g., apples, peeled fruit - cooked; fresh or N/S; baked; 

or wheat flour - cooked; fresh or N/S, baked) using publicly available recipe translation files 

Page 5 of20 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

developed jointly by USDA/ ARS and EPA. For chronic exposure assessment, consumption data 

are averaged for the entire U.S. population and within population subgroups. However, for acute 

exposure assessment, consumption data are retained as individual consumption events. Based on 

analysis of the 2003-2008 WWEIA consumption data, which took into account dietary patterns 

and survey respondents, HED concluded that it is most appropriate to report risk for the 

following population subgroups: the general U.S. population, all infants (<1-year old), children 

1-2, children 3-5, children 6-12, youth 13-19, adults 20-49, females 13-49, and adults 50-99 

years old. 

For a chronic dietary exposure assessment, an estimate of the residue level in each food or foodform (e.g., orange or orange juice) on the food commodity residue list is multiplied by the 

average daily consumption estimate for that food/food form to produce a residue intake estimate. 

The resulting residue intake estimate for each food/food form is summed with the residue intake 

estimates for all other food/food forms on the commodity residue list to arrive at the total 

average estimated exposure. Exposure is expressed in mg/kg body weight/day and as a percent 

of the cPAD. This procedure is performed for each population subgroup. 

For an acute exposure assessment, individual one-day food consumption data are used on an 

individual-by-individual basis. The reported consumption amounts of each food item can be 

multiplied by a residue point estimate and summed to obtain a total daily pesticide exposure for a 

deterministic exposure assessment, or "matched" in multiple random pairings with residue values 

and then summed in a probabilistic assessment. The resulting distribution of exposures is 

expressed as a percentage of the aP AD on both a user (i.e., only those who reported eating 

relevant commodities/food forms) and a per-capita (i.e., those who reported eating the relevant 

commodities as well as those who did not) basis. In accordance with HED policy, per capita 

exposure and risk are reported for analyses performed at all levels of refinement. However, for 

deterministic assessments, any significant differences in user vs. per capita exposure and risk are 

specifically identified and noted in the risk assessment. 

VI. Toxicological Information 

Table 5. Summary of Toxicological Doses and Endpoints for Safl ufenacil for Use in Dietary Human-Health Risk 

Assessments. 

Exposure/ Point of Uncertainty/ RID, PAD, 

Scenario Departure FQPA SFs LOC for Risk Study and Toxicological Effects 

Assessment 

Acute Dietary NOAEL = 500 UFA = !OX Acute RID = Acute Neurotoxicity Study (rat) 

(General mg/kg/day UFH = !OX 5.0 mg/kg NOAEL = 500 (M) and 2000 (F) mg/kg/day. 

Population, LOA EL was 2000 mg/kg/day (males) based on 

including FQPA SF = IX aPAD = 5.0 the decreased motor activity representing mild 

Infants and mg/kg and transient systemic toxicity. 

Children) LOA EL was not established for females. 

Chronic NOAEL = 4.6 UFA= IOX Chronic RID Chronic/Carcinogenicity (mouse) 

Dietary (All mg/kg/day UFH = IOX = 0.046 NOAEL = 4.6 mg/kg bw/d (males) and 18.9 

Populations) mg/kg/day mg/kg bw/d (females). 

FQPA SF = IX 

LOAELs = I 3.8 mg/kg bw/d (males) and 38.1 

cPAD = 0.046 mg/kg bw/day (females) based on decreased 

mg/kg/day red blood cells, hemoglobin, and hematocrit 

and oornhvria observed in the satellite group. 

Cancer (oral, Classification: Not carcinogenic based on the lack of tumors in the mouse and rat carcinogeoicity 

dermal, studies and lack of mutagenicity. 

inhalation) 

Page 6 of20 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

NOA EL = no-observed adverse-effect level. LOA EL= lowest-observed adverse-effect level. UF = uncertainty 

factor. UF" = extrapolation from animal to human (interspecies). UFH = potential variation in sensitivity among 

members of the human population (intraspecies). FQPA SF = FQPA Safety Factor. PAD = population-adjusted 

dose (a = acute, c = chronic). RID = reference dose. LOC = level of concern. 

VII. Results/Discussion 

For acute and chronic assessments, HED is concerned when dietary risk exceeds 100% of the 

PAD. The DEEM-FCID analyses estimate the dietary exposure of the U.S. population and 

various population subgroups. The results reported in Table 6 are for the general U.S. 

population, all infants (<1-year old), children 1-2 years old, children 3-5 years old, children 6-12 

years old, youth 13-19 years old, females 13-49 years old, adults 20-49 years old, and adults 50-

99 years old. 

Results of Acute and Chronic Dietary Exposure Analyses 

The acute dietary risk for food and drinking water utilized < I% of the aPAD for the U.S. 

population at the 95Lh percentile of exposure. The acute dietary risk for the highest exposed 

population subgroup, all infants (< I-year old), is <1% of the aPAD at the 95th percentile. 

The chronic dietary risk for food and drinking water utilized 9.2% of the cPAD for the U.S. 

population. The chronic dietary risk for the highest exposed population subgroup, all infants 

(<I-year old), is 20% of the cPAD. 

The results of the acute and chronic dietary exposure analyses are reported in Table 6. 

Table 6. Summary of Dietary (Food a nd Drinkin2 Water) Ex 1osurc Risk for Saflufenacil. 

Acute Dietary Chronic Dietary (95'h Percentile) Population Subgroup Dietary Exposure Dietary Exposure 

(mg/kg/day) %aPAD (mg/kg/day) %cPAD 

General U.S. Population 0.010106 <I 0.004223 9.2 

All ln fants (<I-year old) 0.026582 < I 0.009099 20 

Children 1-2 years old 0.017044 <I 0.008368 18 

Ch ildren 3-5 years old 0.013965 <I 0.006993 15 

Ch ildren 6-12 years old 0.010852 <I 0.004872 11 

Youth 13- 19 years old 0.008383 <I 0.003409 7.4 

Adults 20-49 years old 0.009095 <I 0.003946 8.6 

Adults 50-99 years old 0.007781 <I 0.003679 8.0 

Females 13-49 years old 0.009078 <I 0.003759 8.2 

•The values for the highest exposed population for each type of risk assessment arc boldcd. 

VIII. Characterization of Inputs/Outputs 

These acute and chronic dietary exposure and risk estimates are conservative since they assumed 

l 00% CT, DEEM 7.81 default concentration factors, and tolerance-level or higher residues (for 

some crops, a correction factor was applied to the tolerance level to account for the M800H02 

metabolite) and were based on screening level estimates of drinking water concentrations 

generated by Tier I Rice modeling. They could be further refined through the use of anticipated 

residues, empirical processing factors, and% CT data, as well as refined drinking water 

estimates. In order to provide a comparison for reference, the dietary results for the analysis of 

food exposures (only) are presented in attachments 5 & 6. 

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Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

IX. Conclusions 

The acute and chronic dietary exposure and risk analyses using DEEM-FCID indicates that 

dietary risks to saflufenacil from food and drinking water are well below HED's levels of 

concern for this pesticide. Estimated acute dietary risks are <1 % of the aP AD at the 95th 

percentile for the general U.S. population and aJI population subgroups, and estimated chronic 

dietary risks are 90% of the cPAD for the general U.S. population and all population subgroups. 

HED is confident that the assessment does not underestimate risk to the general U.S. population 

or any population subgroup. 

X. List of Attachments 

Attachment I: DEEM-FCID Acute Residue File. 

Attachment 2: DEEM-FCID Acute Exposure and Risk Estimates 

Attachment 3: DEEM-FCID Chronic Residue File. 

Attachment 4: DEEM-FCID Chronic Exposure and Risk Estimates. 

Attachment 5: DEEM-FCID Acute Exposure and Risk Estimates (food only). 

Attachment 6: DEEM-FCID Chronic Exposure and Risk Estimates (food only). 

cc: G. Kramer (RABI) 

RDI: DESAC (4/29115) 

G.F. Kramer:S I 0957:PY-S:(703)305-5079:7509P:RAB I 

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Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

Attachment 1: DEEM-FCID Acute Residue File. 

Filename : C: \Users\gkramer\Documents\Gk\##Saflufenacil\SAFLUFENACIL ACUTE . ROB 

Chemical : Saflufenacil -

RfD(Chronic) : . 046 mg/kg bw/day NOEL(Chronic) : O mg/kg bw/day 

RfD(Acute) : 5 mg/kg bw/day NOEL(Acute) : 0 mg/kg bw/day 

Date created/last modified : 03 - 13-2014/09 : 46 : 30 Program ver . 3 . 16, 03 - 08 - d 

EPA Crop 

Code Grp Commodity Name 

9500023000 0 

9500024000 0 

9500024001 0 

9500023001 0 

9500116000 0 

9500115000 0 

9500177000 0 

9500178000 0 

9500215000 0 

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9500283000 0 

9500284000 0 

9500289000 0 

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9500363001 0 

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0603041000 6C 

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0601043001 6A 

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0603182001 6C 

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0601257000 6A 

0603258000 6C 

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0602255000 6B 

0602255001 68 

0603348000 6C 

0603348001 6C 

0600350000 6 

0600350001 6 

0600347000 6 

0600349000 6 

0600349001 6 

1001106000 lOA 

1001107000 lOA 

1001108000 lOA 

Banana 

Banana , dried 

Banana , dried- babyfood 

Banana- babyfood 

Coffee , instant 

Coffee , roasted bean 

Grape , leaves 

Grape , raisin 

Mango 

Mango , dried 

Mango , juice 

Mango , juice-babyfood 

Olive 

Olive, oil 

Plantain 

Plantain, dried 

Pomegranate 

Sugarcane, mol asses 

Sugarcane, molasses- babyfood 

Sugarcane, sugar 

Sugar cane , sugar-babyfood 

Bean, great northern, seed 

Bean, black, seed 

Bean, broad, seed 

Bean, broad, succulent 

Bean, cowpea , seed 

Bean, cowpea , succulent 

Bean, kidney , seed 

Bean , lima , seed 

Bean, lima , succulent 

Bean, mung , seed 

Bean, navy , seed 

Bean, pink, seed 

Bean, pinto, seed 

Bean, snap, succulent 

Bean, snap, succulent-babyfood 

Chickpea , flour 

Chickpea , seed 

Chickpea , seed- babyfood 

Guar, seed 

Guar, seed-babyfood 

Lentil, seed 

Pea , dry 

Pea , dry-babyfood 

Pea , edible podded , succulent 

Pea , pigeon, seed 

Pea , pigeon, succulent 

Pea , succulent 

Pea , succulent-babyfood 

Soybean, flour 

Soybean, f lour-babyfood 

Soybean, oil 

Soybean, oil-babyfood 

Soybean, seed 

Soybean, soy milk 

Soybean, soy milk- babyfood or in 

Citron 

Citrus hybrids 

Citrus, oil 

Def Res 

(ppm) 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

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0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 080000 

0 . 080000 

0 . 050000 

0 . 050000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 030000 

0 . 510000 

0 . 030000 

0 . 510000 

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0 . 030000 

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0 . 510000 

0 . 510000 

0 . 510000 

0 . 030000 

0 . 030000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 030000 

0 . 510000 

0 . 030000 

0 . 030000 

0 . 030000 

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0 . 170000 

0 . 170000 

0 . 170000 

0 . 170000 

0 . 170000 

0 . 030000 

0 . 030000 

0 . 030000 

Page 9 of20 

Adj . Factors 

#1 #2 

1 . 000 

3 . 900 

3 . 900 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

4 . 300 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

Comment 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

1003180000 lOC Grapefruit 0 . 030000 1 . 000 1 . 000 

1003181000 lOC Grapefruit , juice 0 . 030000 2 . 100 1 . 000 

1002197000 108 Kumquat 0 . 030000 1 . 000 1 . 000 

1002199000 108 Lemon 0 . 030000 1 . 000 1 . 000 

1002200000 108 Lemon , juice 0 . 030000 2 . 000 1 . 000 

1002200001 108 Lemon , juice-baby food 0 . 030000 2 . 000 1 . 000 

1002201000 ! OB Lemon , peel 0 . 030000 1 . 000 1 . 000 

1002206000 lOB Lime 0 . 030000 1 . 000 1 . 000 

1002207000 108 Lime , juice 0 . 030000 2 . 000 1 . 000 

1002207001 108 Lime , juice- babyfood 0 . 030000 2 . 000 1 . 000 

1001240000 lOA Orange 0 . 030000 1 . 000 1 . 000 

1001241000 lOA orange , juice 0 . 030000 1 . 800 1 . 000 

1001241001 lOA Orange, juice- babyfood 0 . 030000 1 . 800 1 . 000 

1001242000 lOA Orange , peel 0 . 030000 1 . 000 1 . 000 

1003307000 lOC Pummelo 0 . 030000 1 . 000 1 . 000 

1001369000 lOA Tangerine 0 . 030000 1 . 000 1 . 000 

1001370000 lOA Tangerine , juice 0 . 030000 2 . 300 1 . 000 

1100009000 11 Apple , dried 0 . 030000 8 . 000 1 . 000 

1100009001 11 Apple , dried- baby food 0 . 030000 8 . 000 1 . 000 

1100007000 11 Apple , fruit with peel 0 . 030000 1 . 000 1 . 000 

1100010000 11 Apple , juice 0 . 030000 1 . 300 1 . 000 

1100010001 11 Apple , juice- babyfood 0 . 030000 1 . 300 1 . 000 

1100008000 11 Apple , peeled fruit 0 . 030000 1 . 000 1 . 000 

1100008001 11 Apple , peeled fruit- babyfood 0 . 030000 1 . 000 1 . 000 

1100011000 11 Apple , sauce 0 . 030000 1 . 000 1 . 000 

1100011001 11 Apple , sauce-baby food 0 . 030000 1 . 000 1 . 000 

1100129000 11 Crabapple 0 . 030000 1 . 000 1 . 000 

1100210000 11 Loquat 0 . 030000 1 . 000 1 . 000 

1100266000 11 Pear 0 . 030000 1 . 000 1 . 000 

1100267000 11 Pear, dried 0 . 030000 6 . 250 1 . 000 

1100268000 11 Pear, juice 0 . 030000 1. 000 1 . 000 

1100268001 11 Pear, juice-babyfood 0 . 030000 1. 000 1 . 000 

1100266001 11 Pear-baby food 0 . 030000 1 . 000 1 . 000 

1100310000 11 Quince 0 . 030000 1 . 000 1 . 000 

1202012000 128 Apricot 0 . 030000 1 . 000 1 . 000 

1202013000 128 Apricot, dried 0 . 030000 6 . 000 1 . 000 

1202014000 128 Apricot, juice 0 . 030000 1 . 000 1 . 000 

1202014001 12B Apricot, juice-babyfood 0 . 030000 1 . 000 1 . 000 

1202012001 128 Apricot-babyfood 0 . 030000 1 . 000 1 . 000 

1201090000 12A Cherry 0 . 030000 1 . 000 1 . 000 

1201091000 12A Cherry, juice 0 . 030000 1 . 500 1 . 000 

1201091001 12A Cherry, juice- babyfood 0 . 030000 1 . 500 1 . 000 

1201090001 12A Cherry-babyfood 0 . 030000 1 . 000 1 . 000 

1202230000 128 Nectarine 0 . 030000 1 . 000 1 . 000 

1202260000 128 Peach 0 . 030000 1 . 000 1 . 000 

1202261000 128 Peach, dried 0 . 030000 7 . 000 1 . 000 

1202261001 128 Peach, dried-babyfood 0 . 030000 7 . 000 1 . 000 

1202262000 128 Peach, juice 0 . 030000 1.000 1 . 000 

1202262001 128 Peach, juice- babyfood 0 . 030000 1 . 000 1 . 000 

1202260001 12B Peach-baby food 0 . 030000 1 . 000 1 . 000 

1203285000 12C Plum 0 . 030000 1 . 000 1 . 000 

1203287000 12C Plum, prune , dried 0 . 030000 5 . 000 1 . 000 

1203287001 12C Plum, prune , dried- babyfood 0 . 030000 5 . 000 1 . 000 

1203286000 12C Plum, prune , fresh 0 . 030000 1 . 000 1 . 000 

1203286001 12C Plum, prune , fresh- baby food 0 . 030000 1 . 000 1 . 000 

1203288000 12C Plum, prune , juice 0 . 030000 1. 400 1 . 000 

1203288001 12C Plum, prune , juice- babyfood 0 . 030000 1 . 400 1 . 000 

1203285001 12C Plum-baby food 0 . 030000 1 . 000 1 . 000 

1304175000 130 Grape 0 . 030000 1 . 000 1 . 000 

1304176000 130 Grape , juice 0 . 030000 1.200 1 . 000 

1304176001 130 Grape , juice-babyfood 0 . 030000 1.200 1 . 000 

1304179000 130 Grape , wine and s herry 0 . 030000 1 . 000 1 . 000 

1400003000 H Almond 0 . 030000 1 . 000 1 . 000 

1400004000 14 Almond , oil 0 . 030000 1 . 000 1 . 000 

1400004001 14 Almond , oil- babyfood 0 . 030000 1 . 000 1 . 000 

1400003001 14 Almond-baby food 0 . 030000 1 . 000 1 . 000 

1400059000 14 Brazil nut 0 . 030000 1 . 000 1 . 000 

1400068000 14 Butternut 0 . 030000 1 . 000 1 . 000 

1400081000 14 Cashew 0 . 030000 1 . 000 1 . 000 

1400092000 14 Chestnut 0 . 030000 1 . 000 1 . 000 

1400155000 14 Hazelnut 0 . 030000 1 . 000 1 . 000 

Page JO of 20 
Sa flu fenaci I Dietary Exposure and Risk Assessment DP Number: 426932 

1400156000 14 Hazelnut, oil 0 . 030000 1 . 000 1 . 000 

1400185000 14 Hickory nut 0 . 030000 1 . 000 1 . 000 

1400213000 14 Macadamia nut 0 . 030000 1 . 000 1 . 000 

1400269000 14 Pecan 0 . 030000 1 . 000 1 . 000 

1400282000 14 Pistachio 0 . 030000 1 . 000 1 . 000 

1400391000 14 Walnut 0 . 030000 1.000 1.000 

1500027000 15 Barley, bran 1 . 500000 1 . 000 1 . 000 

1500026000 15 Barley, flour 1 . 000000 1 . 000 1 . 000 

1500026001 15 Barley, flour-babyfood 1 . 000000 1 . 000 1 . 000 

1500025000 15 Barley, pearl ed barley 1 . 000000 1 . 000 1 . 000 

1500025001 15 Barley, pearled barley- babyfood 1 . 000000 1 . 000 1 . 000 

1500065000 15 Buckwheat 0 . 030000 1 . 000 1 . 000 

1500066000 15 Buckwheat , flour 0 . 030000 1 . 000 1 . 000 

1500122000 15 Corn , field, bran 0 . 030000 1 . 000 1 . 000 

1500120000 15 Corn , field, flour 0 . 030000 1 . 000 1 . 000 

1500120001 15 Corn , field, flour- babyfood 0 . 030000 1 . 000 1 . 000 

1500121000 15 Corn , field, meal 0 . 030000 1 . 000 1 . 000 

1500121001 15 Corn , field, meal- babyfood 0 . 030000 1 . 000 1 . 000 

1500125000 15 Corn , field, oil 0 . 030000 1 . 000 1 . 000 

1500125001 15 Corn , field , oil-babyfood 0 . 030000 1 . 000 1 . 000 

1500123000 15 Corn , field, starch 0 . 030000 1 . 000 1 . 000 

1500123001 15 Corn , field, starch- baby food 0 . 030000 1 . 000 1 . 000 

1500124000 15 Corn , field, syrup 0 . 030000 1 . 500 1 . 000 

1500124001 15 Corn , field, syrup-babyfood 0 . 030000 1 . 500 1 . 000 

1500126000 15 Corn , pop 0 . 030000 1 . 000 1 . 000 

1500127000 15 Corn , sweet 0 . 030000 1 . 000 1 . 000 

1500127001 15 Corn , sweet-baby food 0 . 030000 1 . 000 1 . 000 

1500226000 15 Millet , grain 0 . 030000 1 . 000 1 . 000 

1500231000 15 Oat, bran 0 . 030000 1 . 000 1 . 000 

1500232000 15 Oat , flour 0 . 030000 1 . 000 1 . 000 

1500232001 15 Oat , flour-babyf ood 0 . 030000 1 . 000 1 . 000 

1500233000 15 Oat , groats/rolled oa ts 0 . 030000 1 . 000 1 . 000 

1500233001 15 Oat , groats/rolled oa ts-ba byfood 0 . 030000 1 . 000 1 . 000 

1500326000 15 Rice , bran 0 . 030000 1 . 000 1 . 000 

1500326001 15 Rice , bran-babyfood 0 . 030000 1 . 000 1 . 000 

1500324000 15 Rice , brown 0 . 030000 1 . 000 1 . 000 

1500324001 15 Rice , brown- baby food 0 . 030000 1 . 000 1 . 000 

1500325000 15 Rice , flour 0 . 030000 1 . 000 1 . 000 

1500325001 15 Rice , flour- baby food 0 . 030000 1 . 000 1 . 000 

1500323000 15 Rice , white 0 . 030000 1 . 000 1 . 000 

1500323001 15 Rice , white-babyfood 0 . 030000 1 . 000 1 . 000 

1500329000 15 Rye , flour 0 . 030000 1 . 000 1.000 

1500328000 15 Rye , grain 0 . 030000 1 . 000 1 . 000 

1500344000 15 Sorghum, grain 0 . 030000 1. 000 1.000 

1500345000 15 Sorghum, syrup 0 . 030000 1.000 1.000 

1500381000 15 Triticale, f l our 0 . 030000 1 . 000 1 . 000 

1500381001 15 Triticale, flour-baby f ood 0 . 030000 1 . 000 1 . 000 

1500404000 15 Wheat , bran 0 . 600000 1 . 000 1.000 

1500402000 15 Wheat, flour 0 . 600000 1 . 000 1 . 000 

1500402001 15 Wheat , flour- baby food 0 . 600000 1 . 000 1 . 000 

1500403000 15 Wheat , germ 0 . 600000 1 . 000 1 . 000 

1500401000 15 Wheat , grain 0 . 600000 1 . 000 1 . 000 

1500401001 15 Wheat, grain-babyfood 0 . 600000 1 . 000 1 . 000 

1500405000 15 Wild rice 0 . 030000 1 . 000 1 . 000 

2003128000 20C Cottonseed, oil 0 . 340000 1 . 000 1 . 000 

2003128001 20C Cottonseed, oil- babyfood 0 . 340000 1 . 000 1 . 000 

2001163000 20A Flax seed, oil 0 . 760000 1 . 000 1 . 000 

2001319000 20A Rapeseed , oil 0 . 760000 1 . 000 1 . 000 

2001319001 20A RapeseeGI, oil-ba by food 0 . 760000 1 . 000 1 . 000 

2002330000 208 Safflower, oil 1 . 700000 1 . 000 1 . 000 

2002330001 208 Safflower, oil - baby f ood 1 . 700000 1 . 000 1 . 000 

2001337000 20A Sesame , oil 0 . 760000 1 . 000 1 . 000 

2001337001 20A Sesame , oil-babyfood 0 . 760000 1 . 000 1 . 000 

2001336000 20A Sesame , seed 0 . 760000 1 . 000 1.000 

2001336001 20A Sesame , seed-baby food 0 . 760000 1 . 000 1 . 000 

2002365000 20B Sunflower, oil 1 . 700000 1 . 000 1 . 000 

2002365001 20B Sunflower, oil-babyfood 1 . 700000 1 . 000 1 . 000 

2002364000 20B Sunflower, seed 1 . 700000 1 . 000 1 . 000 

3100047000 31 Beef, fat 0 . 040000 1 . 000 1 . 000 

3100047001 31 Beef, fat-babyf ood 0 . 0 40000 1 . 000 1 . 000 

3100048000 31 Beef, kidney 0 . 300000 1 . 000 1 . 000 

Page 11 of20 
Satlufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

3100049000 31 Beef, liver 50 . 000000 1 . 000 1 . 000 

3100049001 31 Beef, liver- babyfood 50 . 000000 1 . 000 1 . 000 

3100044000 31 Beef, meat 0 . 020000 1 . 000 1 . 000 

3100046000 31 Beef, meat byproducts 0 . 300000 1 . 000 1 . 000 

3100046001 31 Beef, meat byproducts-babyfood 0 . 300000 1 . 000 1 . 000 

3100045000 31 Beef, meat , dried 0 . 020000 1. 920 1.000 

3100044001 31 Beef, meat-babyfood 0 . 020000 1 . 000 1 . 000 

3200171000 32 Goat , fat 0 . 040000 1 . 000 1 . 000 

3200172000 32 Goat , kidney 0 . 300000 1 . 000 1 . 000 

3200173000 32 Goat , liver 50 . 000000 1 . 000 1.000 

3200169000 32 Goat , meat 0 . 020000 1 . 000 1 . 000 

3200170000 32 Goat , meat byproducts 0 . 300000 1 . 000 1 . 000 

3300189000 33 Horse , meat 0 . 020000 1 . 000 1 . 000 

3400293000 34 Pork , fat 0 . 010000 1 . 000 1 . 000 

3400293001 34 Pork , fat-baby food 0 . 010000 1 . 000 1 . 000 

3400294000 34 Pork, kidney 0 . 010000 1 . 000 1 . 000 

3400295000 34 Pork, liver 2 . 000000 1 . 000 1 . 000 

3400290000 34 Pork, meat 0 . 010000 1 . 000 1 . 000 

3400292000 34 Pork , meat byproducts 0 . 020000 1 . 000 1 . 000 

3400292001 34 Pork, meat byproduct s-babyfood 0 . 020000 1 . 000 1 . 000 

3400290001 34 Pork, meat-babyfood 0 . 010000 1 . 000 1 . 000 

3400291000 34 Pork, skin 0 . 010000 1 . 000 1 . 000 

3500341000 35 Sheep, fat 0 . 040000 1 . 000 1 . 000 

3500341001 35 Sheep, fat-babyfood 0 . 040000 1 . 000 1 . 000 

3500342000 35 Sheep, kidney 0 . 300000 1 . 000 1 . 000 

3500343000 35 Sheep, liver 50 . 000000 1 . 000 1 . 000 

3500339000 35 Sheep, meat 0 . 020000 1 . 000 1 . 000 

3500340000 35 Sheep, meat byproducts 0 . 300000 1 . 000 1 . 000 

3500339001 35 Sheep, meat-baby food 0 . 020000 1 . 000 1 . 000 

3600222000 36 Milk , fat 0 . 010000 1 . 000 1 . 000 

3600222001 36 Milk, fat-baby food/infant formu 0 . 010000 1 . 000 1 . 000 

3600223000 36 Milk , nonfat solids 0 . 010000 1 . 000 1 . 000 

3600223001 36 Milk, nonfat solids- baby food/in 0 . 010000 1 . 000 1 . 000 

3600225001 36 Milk , sugar (lactose) - baby food/ 0 . 010000 1 . 000 1.000 

3600224000 36 Milk , water 0 . 010000 1 . 000 1 . 000 

3600224001 36 Milk , water- babyfood/infant form 0 . 010000 1 . 000 1 . 000 

3900312000 39 Rabbit , meat 0 . 010000 1 . 000 1 . 000 

8000157000 80 Fish-freshwater finfish 0 . 010000 1.000 1 . 000 

8000158000 80 Fish-freshwater finfish , farm ra 0 . 010000 1 . 000 1 . 000 

8000160000 80 Fish-saltwater finfish , other 0 . 010000 1 . 000 1 . 000 

8000159000 80 Fish-saltwater finfish , tuna 0 . 010000 1 . 000 1 . 000 

8000161000 80 Fish-shellfish, crustacean 0 . 010000 1 . 000 1 . 000 

8601000000 86A Water, direct, all sources 0 . 133000 1 . 000 1 . 000 

8602000000 86B Water, indirect, all sources 0 . 133000 1 . 000 1 . 000 

Page 12 of20 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

Attachment 2: DEEM-FCID Acute Exposure and Risk Estimates. 

US EPA 

DEEM-FCID ACUTE Analysis for SAFLUFENACIL 

Residue file : SAFLUFENACIL ACUTE . ROS 

Ver . 3 . 18, 03 - 08 - d 

NHANES 2003 - 2008 2- Day 

Adjustment factor #2 NOT used . 

Analysis Date : 04 - 23- 2015/l4 : 51 :05 Residue file dated : 04 - 23- 2015/14 : 45 : 35 

RAC/FF intake sununed over 24 hours 

Run Comment : "" 

Sununary calculations--per capita : 

95th Percentile 99th Percentile 99 . 9th Percentile 

Exposure % aRfD Exposure % aRfD Exposure % aRf D 

---------- -------- ---------- -------- ---------- -------- Total us Population : 

0 . 010106 0 . 20 0 . 015835 0 . 32 0 . 034046 0 . 68 

All Infants: 

0 . 026582 0 . 53 0 . 035623 0 . 71 0 . 050604 1.01 

Children 1- 2 : 

0 . 017044 0 . 34 0 . 025485 0 . 51 0 . 048980 0 . 98 

Children 3-5 : 

0 . 013965 0 . 28 0 . 019801 0 . 40 0 . 028593 0 . 57 

Children 6-12 : 

0 . 010852 0 . 22 0 . 015593 0 . 31 0 . 026214 0 . 52 

Youth 13- 19 : 

0 . 008383 0 . 17 0 . 013120 0 . 26 0 . 018114 0 . 36 

Adults 20-49 : 

0 . 009095 0 . 18 0 . 012821 0 . 26 0 . 023217 0 . 4 6 

Adults 50-99 : 

0 . 007781 0 . 16 0 . 011959 0 . 24 0 . 052739 1. 05 

Female 13-49 : 

0 . 009078 0 . 18 0 . 012576 0 . 25 0 . 019768 0 . 40 

Page 13 of20 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

Attachment 3: DEEM-FCID Chronic Residue File. 

Filename : C: \Users\gkramer\Documents\Gk\##Saflufenacil\SAFLUFENACIL CHRONIC . ROB 

Chemical : Saflufenacil -

RfD(Chronic) : . 046 mg/kg bw/day NOEL(Chronic) : 0 mg/kg bw/ day 

RfD(Acute) : 5 mg/kg bw/day NOEL(Acute) : 0 mg/kg bw/day 

Date created/last modified : 03-13- 2014/09 : 47 : 24 Program ver. 3 . 16, 03-08-d 

EPA Crop 

Code Grp Commodity Name 

9500023000 0 

9500024000 0 

9500024001 0 

9500023001 0 

9500116000 0 

9500115000 0 

9500177000 0 

9500178000 0 

9500215000 0 

9500216000 0 

9500217000 0 

9500217001 0 

9500235000 0 

9500236000 0 

9500283000 0 

9500284000 0 

9500289000 0 

9500363000 0 

9500363001 0 

9500362000 0 

9500362001 0 

0603035000 6C 

0603030000 6C 

0603032000 6C 

0602031000 6B 

0603034000 6C 

0602033000 6B 

0603036000 6C 

0603038000 6C 

0602037000 6B 

0603039000 6C 

0603040000 6C 

0603041000 6C 

0603042000 6C 

0601043000 6A 

0601043001 6A 

0603099000 6C 

0603098000 6C 

0603098001 6C 

0603182000 6C 

0603182001 6C 

0603203000 6C 

0603256000 6C 

0603256001 6C 

0601257000 6A 

0603258000 6C 

0602259000 6B 

0602255000 6B 

0602255001 6B 

0603348000 6C 

0603348001 6C 

0600350000 6 

0600350001 6 

0600347000 6 

0600349000 6 

0600349001 6 

1001106000 lOA 

1001107000 lOA 

1001108000 lOA 

Banana 

Banana , dried 

Banana , dried- babyfood 

Banana-babyfood 

Coffee , instant 

Coffee , roasted bean 

Grape , leaves 

Grape , raisin 

Mango 

Mango, dried 

Mango, juice 

Mango, Juice- babyfood 

Olive 

Olive, oil 

Plantain 

Plantain , dried 

Pomegranate 

Sugarcane, molasses 

Sugarcane, molasses-babyfood 

Sugarcane, sugar 

Sugarcane, sugar- bab yfood 

Bean, great northern, seed 

Bean, black, seed 

Bean, broad, seed 

Bean, broad, succulent 

Bean, 

Bean, 

Bean, 

Bean, 

cowpea, seed 

cowpea, succulent 

kidney, seed 

lima , seed 

Bean, lima , succulent 

Bean, mung , seed 

Bean, navy , seed 

Bean, pink, seed 

Bean, pinto, seed 

Bean, snap, succulent 

Bean, snap, succulent- babyfood 

Chickpea , flour 

Chickpea , seed 

Chickpea , seed- babyfood 

Guar, seed 

Guar, seed-babyfood 

Lentil, seed 

Pea , dry 

Pea , dry-babyfood 

Pea , edible podded , succulent 

Pea , pigeon, seed 

Pea , pigeon, succulent 

Pea , succulent 

Pea , succulent-babyfood 

Soybean, flour 

Soybean, flour-babyfood 

Soybean, oil 

Soybean, oil-babyfood 

Soybean, seed 

Soybean, soy milk 

Soybean, soy milk- babyfood or in 

Citron 

Citrus hybrids 

Citrus, oil 

Def Res 

(ppm) 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 080000 

0 . 080000 

0 . 050000 

0 . 050000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 030000 

0 . 510000 

0 . 030000 

0 . 510000 

0 . 510000 

0 . 030000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 030000 

0 . 030000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 510000 

0 . 030000 

0 . 510000 

0 . 030000 

0 . 030000 

0 . 030000 

0 . 170000 

0 . 170000 

0 . 170000 

0 . 170000 

0 . 170000 

0 . 170000 

0 . 170000 

0 . 030000 

0 . 030000 

0 . 030000 

Page 14 of20 

Adj . Factors Comment 

#1 #2 

1 . 000 

3 . 900 

3. 900 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

4 . 300 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1.000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 

1 . 000 
Satlufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

1003180000 lOC Grapefruit 0 . 030000 1 . 000 1 . 000 

1003181000 lOC Grapefruit, juice 0 .030000 2 .100 1.000 

1002197000 lOB Kumquat 0 . 030000 1 . 000 1 . 000 

1002199000 lOB Lemon 0 . 030000 1 . 000 1 . 000 

1002200000 lOB Lemon , juice 0 . 030000 2 . 000 1 . 000 

1002200001 lOB Lemon , juice- babyfood 0 . 030000 2 . 000 1 . 000 

1002201000 lOB Lemon , peel 0 . 030000 1 . 000 1 . 000 

1002206000 lOB Lime 0 . 030000 1 . 000 1 . 000 

1002207000 lOB Lime , juice 0 . 030000 2 . 000 1 . 000 

1002207001 lOB Lime , juice-babyfood 0 . 030000 2 . 000 1 . 000 

1001240000 lOA Orange 0 . 030000 1 . 000 1 . 000 

1001241000 lOA Orange , ) Ul.Ce 0 . 030000 1 . 800 1 . 000 

1001241001 lOA Orange , j uice- baby food 0 . 030000 1 . 800 1 . 000 

1001242000 lOA Orange , peel 0 . 030000 1 . 000 1 . 000 

1003307000 lOC Pummelo 0 . 030000 1 . 000 1 . 000 

1001369000 lOA Tangerine 0 . 030000 1 . 000 1 . 000 

1001370000 lOA Tangerine , juice 0 . 030000 2 . 300 1 . 000 

1100009000 11 Apple , dried 0 . 030000 8 . 000 1 . 000 

1100009001 11 Apple , dried-babyf ood 0 . 030000 8 . 000 1 . 000 

1100007000 11 Apple , fruit wi th peel 0 . 030000 1 . 000 1 . 000 

1100010000 11 Apple , j uice 0 . 030000 1 . 300 1 . 000 

1100010001 11 Apple , j uice-babyfood 0 . 030000 1 . 300 1 . 000 

1100008000 11 Appl e , peeled fruit 0 . 030000 1 . 000 1 . 000 

1100008001 11 Apple , peeled fruit- babyfood 0 . 030000 1 . 000 1 . 000 

1100011000 11 Apple , sauce 0 . 030000 1 . 000 1 . 000 

1100011001 11 Apple , sauce-babyfood 0 . 030000 1 . 000 1 . 000 

1100129000 11 Crabapple 0 . 030000 1 . 000 1 . 000 

1100210000 11 Loquat 0 . 030000 1 . 000 1 . 000 

1100266000 11 Pear 0 . 030000 1 . 000 1.000 

1100267000 11 Pear, dried 0 . 030000 6. 250 1 . 000 

1100268000 11 Pear, juice 0 . 030000 1 . 000 1 . 000 

1100268001 11 Pear, juice- baby food 0 . 030000 1 . 000 1 . 000 

1100266001 11 Pear-babyf ood 0 . 030000 1.000 1 . 000 

1100310000 11 Quince 0 . 030000 1 . 000 1 . 000 

1202012000 12B Apricot 0 . 030000 1 . 000 1 . 000 

1202013000 12B Apricot, dried 0 . 030000 6. 000 1 . 000 

1202014000 12B Apricot , juice 0 . 030000 1 . 000 1 . 000 

1202014001 12B Apricot, juice-babyfood 0 . 030000 1 . 000 1 . 000 

1202012001 12B Apricot-babyfood 0 . 030000 1 . 000 1 . 000 

1201090000 12A Cherry 0 . 030000 1 . 000 1 . 000 

1201091000 12A Cherry, juice 0 . 030000 1 . 500 1 . 000 

1201091001 12A Cherry, juice-babyfood 0 . 030000 1 . 500 1 . 000 

1201090001 12A Cherry-babyfood 0 . 030000 1 . 000 1 . 000 

1202230000 12B Nectarine 0 . 030000 1 . 000 1 . 000 

1202260000 12B Peach 0 . 030000 1 . 000 1 . 000 

1202261000 128 Peach, dried 0 . 030000 7 . 000 1 . 000 

1202261001 12B Peach, dried- babyfood 0 . 030000 7 . 000 1 . 000 

1202262000 12B Peach, j uice 0 . 030000 1 . 000 1 . 000 

1202262001 12B Peach, juice- babyfood 0 . 030000 1 . 000 1 . 000 

1202260001 12B Peach-babyf ood 0 . 030000 1 . 000 1 . 000 

1203285000 12C Plum 0 . 030000 1 . 000 1 . 000 

1203287000 12C Plum, prune , dried 0 . 030000 5 . 000 1 . 000 

1203287001 12C Plum, prune , dried-babyfood 0 . 030000 5 . 000 1 . 000 

1203286000 12C Plum, prune , fresh 0 . 030000 1 . 000 1 . 000 

1203286001 12C Plum, prune , fresh-babyfood 0 . 030000 1 . 000 1 . 000 

1203288000 12C Plum, prune , juice 0 . 030000 1. 400 1 . 000 

1203288001 12C Plum, prune , juice-babyfood 0 . 030000 1. 400 1 . 000 

1203285001 12C Plum-baby food 0 . 030000 1 . 000 1 . 000 

1304175000 130 Grape 0 . 030000 1 . 000 1 . 000 

1304176000 130 Grape , juice 0 . 030000 1 . 200 1 . 000 

1304176001 130 Grape , juice-babyfood 0 . 030000 1 . 200 1 . 000 

1304179000 130 Grape , wine and sherry 0 . 030000 1 . 000 1 . 000 

1400003000 14 Almond 0 . 030000 1 . 000 1 . 000 

1400004000 14 Almond , oil 0 . 030000 1 . 000 1 . 000 

1400004001 14 Almond , oil-babyfood 0 . 030000 1 . 000 1 . 000 

1400003001 14 Almond-babyfood 0 . 030000 1 . 000 1 . 000 

1400059000 14 Brazil nut 0 . 030000 1 . 000 1 . 000 

1400068000 14 Butternut 0 . 030000 1 . 000 1 . 000 

1400081000 14 Cashew 0 . 030000 1 . 000 1 . 000 

1400092000 14 Chestnut 0 . 030000 1 . 000 1 . 000 

1400155000 14 Hazelnut 0 . 030000 1 . 000 1 . 000 

Page 15 of20 
Satlufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

1400156000 14 Hazelnut, oil 0 . 030000 1 . 000 1 . 000 

1400185000 14 Hickory nut 0 . 030000 1 . 000 1 . 000 

1400213000 14 Macadamia nut 0 . 030000 1 . 000 1 . 000 

1400269000 14 Pecan 0 . 030000 1 . 000 1.000 

1400282000 14 Pistachio 0 . 030000 1 . 000 1 . 000 

1400391000 14 Walnut 0 . 030000 1 . 000 1.000 

1500027000 15 Barley, bran 1 . 500000 1 . 000 1 . 000 

1500026000 15 Barley, flour 1 . 000000 1 . 000 1 . 000 

150002 6001 15 Barley, flour-babyfood 1 . 000000 1 . 000 1 . 000 

1500025000 15 Barley, pearled barley 1 . 000000 1 . 000 1 . 000 

1500025001 15 Barley, pearled barley-babyfood 1 . 000000 1 . 000 1 . 000 

1500065000 15 Buckwheat 0 . 030000 1 . 000 1 . 000 

1500066000 15 Buckwheat , flour 0 . 030000 1 . 000 1 . 000 

1500122000 15 Corn , field , bran 0 . 030000 1.000 1 . 000 

1500120000 15 Corn , field , flour 0 . 030000 1 . 000 1 . 000 

1500120001 15 Corn , field , flour-baby food 0 . 030000 1 . 000 1 . 000 

1500121000 15 Corn , field , meal 0 . 030000 1 . 000 1 . 000 

1500121001 15 Corn , field , meal- baby food 0 . 030000 1 . 000 1 . 000 

1500125000 15 Corn , field , oil 0 . 030000 1 . 000 1 . 000 

1500125001 15 Corn, field , oil-babyfood 0 . 030000 1 . 000 1 . 000 

1500123000 15 Corn , field, starch 0 . 030000 1 . 000 1 . 000 

1500123001 15 Corn , field, starch- baby food 0 . 030000 1 . 000 1 . 000 

1500124000 15 Corn , field , syrup 0 . 030000 1 . 500 1 . 000 

1500124001 15 Corn , field , syrup- baby food 0 . 030000 1 . 500 1 . 000 

1500126000 15 Corn , pop 0 . 030000 1 . 000 1 . 000 

1500127000 15 Corn , sweet 0 . 030000 1 . 000 1 . 000 

1500127001 15 Corn, sweet-baby food 0 . 030000 1 . 000 1 . 000 

1500226000 15 Millet , grain 0 . 030000 1 . 000 1 . 000 

1500231000 15 Oat , bran 0 . 030000 1 . 000 1 . 000 

1500232000 15 Oat , flour 0 . 030000 1 . 000 1 . 000 

1500232001 15 Oat , flour- babyf ood 0 . 030000 1 . 000 1 . 000 

1500233000 15 Oat , groats/rolled oats 0 . 030000 1 . 000 1 . 000 

1500233001 15 Oat , groats/rolled oats- babyfood 0 . 030000 1 . 000 1 . 000 

1500326000 15 Rice , bran 0 . 030000 1 . 000 1 . 000 

1500326001 15 Rice , bran-babyfood 0 . 030000 1 . 000 1.000 

1500324000 15 Rice , brown 0 . 030000 1 . 000 1 . 000 

1500324001 15 Rice , brown-baby food 0 . 030000 1 . 000 1 . 000 

1500325000 15 Rice , flour 0 . 030000 1 . 000 1 . 000 

1500325001 15 Rice , flour-babyfood 0 . 030000 1 . 000 1 . 000 

1500323000 15 Rice, white 0 . 030000 1 . 000 1 . 000 

1500323001 15 Rice , white-babyfood 0 . 030000 1 . 000 1 . 000 

1500329000 15 Rye , flour 0 . 030000 1 . 000 1 . 000 

1500328000 15 Rye , grain 0 . 030000 1 . 000 1 . 000 

1500344000 15 Sorghum, grain 0 . 030000 1 . 000 1 . 000 

1500345000 15 Sorghum, syrup 0 . 030000 1 . 000 1 . 000 

1500381000 15 Triticale, f l our 0 . 030000 1 . 000 1 . 000 

1500381001 15 Triticale, flour-babyfood 0 . 030000 1 . 000 1 . 000 

1500404000 15 Wheat, bran 0 . 600000 1 . 000 1 . 000 

1500402000 15 Wheat, flour 0 . 600000 1 . 000 1.000 

1500402001 15 Wheat, flour-babyfood 0 . 600000 1 . 000 1 . 000 

1500403000 15 Wheat , germ 0 . 600000 1 . 000 1 . 000 

1500401000 15 Wheat , grain 0 . 600000 1 . 000 1 . 000 

1500401001 15 Wheat , grain- babyfood 0 . 600000 1 . 000 1 . 000 

1500405000 15 Wild rice 0 . 030000 1.000 1 . 000 

2003128000 20C Cottonseed, oil 0 . 340000 1 . 000 1 . 000 

2003128001 20C Cottonseed, oil- babyfood 0 . 340000 1 . 000 1 . 000 

2001163000 20A Flax seed, oil 0 . 760000 1 . 000 1 . 000 

2001319000 20A Rapeseed, oil 0 . 760000 1 . 000 1 . 000 

2001319001 20A Rapeseed, oil-baby food 0 . 760000 1 . 000 1 . 000 

2002330000 20B Safflower, oil 1 . 700000 1 . 000 1.000 

2002330001 20B Safflower, oil-babyfood 1 . 700000 1 . 000 1 . 000 

2001337000 20A Sesame , oil 0 . 760000 1 . 000 1 . 000 

2001337001 20A Sesame , oil-baby food o. 760000 1 . 000 1 . 000 

2001336000 20A Sesame , seed 0 . 760000 1.000 1 . 000 

2001336001 20A Sesame , seed-baby food 0 . 760000 1 . 000 1 . 000 

2002365000 20B Sunflower, oil l . 700000 1 . 000 1 . 000 

2002365001 20B Sunflower, oil- babyfood 1 . 700000 1 . 000 1.000 

2002364000 20B Sunflower, seed 1 . 700000 1 . 000 1 . 000 

3100047000 31 Beef, fat 0 . 040000 1 . 000 1 . 000 

31000 47001 31 Beef, fat-babyfood 0 . 040000 1 . 000 1 . 000 

3100048000 31 Beef, kidney 0 . 300000 1 . 000 1 . 000 

Page 16 of20 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

3100049000 31 Beef, liver 50 . 000000 1 . 000 1.000 

3100049001 31 Beef, liver-babyfood 50 . 000000 1 . 000 1 . 000 

3100044000 31 Beef, meat 0 . 020000 1 . 000 1 . 000 

3100046000 31 Beef, meat byproducts 0 . 300000 1 . 000 1 . 000 

3100046001 31 Beef, meat byproducts- babyfood 0 . 300000 1 . 000 1 . 000 

3100045000 31 Beef, meat , dried 0 . 020000 1 . 920 1.000 

3100044001 31 Beef, meat- baby food 0 . 020000 1 . 000 1 . 000 

3200171000 32 Goat , fat 0 . 040000 1 . 000 1 . 000 

3200172000 32 Goat , kidney 0 . 300000 1 . 000 1 . 000 

3200173000 32 Goat , liver 50 . 000000 1 . 000 1 . 000 

3200169000 32 Goat , meat 0 . 020000 1 . 000 1 . 000 

3200170000 32 Goat , meat byproducts 0 . 300000 1 . 000 1 . 000 

3300189000 33 Horse , meat 0 . 020000 1 . 000 1 . 000 

3400293000 34 Pork, fat 0 . 010000 1 . 000 1 . 000 

3400293001 34 Pork, fat-babyfood 0 . 010000 1 . 000 1 . 000 

3400294000 34 Pork, kidney 0 . 010000 1 . 000 1 . 000 

3400295000 34 Pork, liver 2 . 000000 1 . 000 1 . 000 

3400290000 34 Pork, meat 0 . 010000 1 . 000 1 . 000 

3400292000 34 Pork, meat byproducts 0 . 020000 1 . 000 1 . 000 

3400292001 34 Pork, meat byproducts-babyfood 0 . 020000 1 . 000 1.000 

3400290001 34 Pork, meat-babyfood 0 . 010000 1 . 000 1 . 000 

3400291000 34 Pork, skin 0 . 010000 1.000 1.000 

3500341000 35 Sheep, fat 0 . 040000 1 . 000 1 . 000 

3500341001 35 Sheep, fat- babyfood 0 . 040000 1 . 000 1 . 000 

3500342000 35 Sheep, ki dney 0 . 300000 1 . 000 1 . 000 

3500343000 35 Sheep, liver 50 . 000000 1 . 000 1 . 000 

3500339000 35 Sheep, meat 0 . 020000 1 . 000 1 . 000 

3500340000 35 Sheep, meat byproducts 0 . 300000 1 . 000 1 . 000 

3500339001 35 Sheep, meat-babyfood 0 . 020000 1 . 000 1 . 000 

3600222000 36 Milk , fat 0 . 010000 1 . 000 1 . 000 

3600222001 36 Milk , fat-baby food/infant forrnu 0 . 010000 1 . 000 1 . 000 

3600223000 36 Milk , nonfat solids 0 . 010000 1 . 000 1 . 000 

3600223001 36 Milk , nonfat solids-baby food/in 0 . 010000 1 . 000 1 . 000 

3600225001 36 Milk , sugar (lactose)-baby food/ 0 . 010000 1 . 000 1 . 000 

3600224000 36 Milk , water 0 . 010000 1 . 000 1 . 000 

3600224001 36 Milk, water-babyfood/inf ant form 0 . 010000 1 . 000 1 . 000 

3900312000 39 Rabbit, meat 0 . 010000 1 . 000 1 . 000 

8000157000 80 Fish-freshwater finfish 0 . 010000 1 . 000 1 . 000 

8000158000 80 Fish- freshwater finfish , farm ra 0 . 010000 1 . 000 1 . 000 

8000160000 80 Fish- saltwater finfish , other 0 . 010000 1.000 1 . 000 

8000159000 80 Fish- saltwater finfish , tuna 0 . 010000 1.000 1 . 000 

8000161000 80 Fish-shellfish, crustacean 0 . 010000 1 . 000 1.000 

8601000000 86A Water, direct , all sources 0 . 120000 1 . 000 1 . 000 

8602000000 86B Water, indirect , all sources 0 . 120000 1 . 000 1 . 000 

Page 17 of20 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

Attachment 4: DEEM-FCID Chronic Exposure and Risk Estimates. 

US EPA Ver . 3 . 16, 03-08- d 

DEEM-FCID Chronic analysis for SAFLUFENACIL NHANES 2003-2008 2- day 

Residue file name : C: \Users\gkramer\Documents\Gk\#ftSaflufenacil\SAFLUFENACIL_CHRONIC .R08 

Adjustment factor #2 used . 

Analysis Date 04-23-2015/14 : 47 : 31 Residue file dated : 04-23-2015/14 : 44 : 13 

Reference dose (RfD, Chronic) = . 046 mg/kg bw/day 

Total exposure by population subgroup 

Total Exposure 

Population 

Subgroup 

Total US Population 

Hispanic 

Non-Hisp-White 

Non-Hisp-Black 

Non-Hisp-Other 

Nursing Infants 

Non-Nursing Infants 

Female 13+ PREG 

Children 1-6 

Children 7-12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13-50 

Children 1-2 

Children 3-5 

Children 6-12 

Youth 13-19 

Adults 20-49 

Adults 50-99 

Female 13-49 

mg/kg 

body wt/day 

0 . 004223 

0 . 004317 

0 . 004263 

0 . 003716 

0 . 004652 

0 . 003456 

0 . 011620 

0 . 003713 

0 . 007392 

0 . 004597 

0 . 003445 

0 . 003378 

0 . 003891 

0 . 003785 

0 . 003608 

0 . 009099 

0 . 003756 

0 . 008368 

0 . 006993 

0 . 004872 

0 . 003409 

0 . 003946 

0 . 003679 

0 . 003759 

Page 18 of20 

Percent of 

Rfd 

9 . 2% 

9 . 4% 

9 . 3% 

8 . 1% 

10 . 1% 

7 . 5% 

25 . 3% 

8 . 1% 

16 . 1% 

10 . 0% 

7 . 5% 

7 . 3% 

8 . 5% 

8 . 2% 

7 . 8% 

19 . 8% 

8 . 2% 

18 . 2% 

15 . 2% 

10 . 6% 

7 . 4% 

8 . 6% 

8 . 0% 

8 . 2% 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

Attachment 5: DEEM-FCID Acute Exposure and Risk Estimates 

US EPA 

DEEM-FCID ACUTE Analysis for SAFLUFENACIL 

Residue file : SAFLUFENACIL Food0nl y . R08 

Analysis Date : 04-23-2015/l4 : 52 : 46 Residue 

Ver . 3 . 18 , 03-08-d 

NHANES 2003- 2008 2-Day 

Adjustment factor #2 NOT used . 

file dated : 04-23-2015/14 : 44 : 54 

RAC/FF intake summed over 24 hours 

Run Comment : "" 

=============================================================================== 

Summary calculations--per capita : 

95th Percentile 99th Percentile 99 . 9t h Percentile 

Exposure % aRfD Exposure % aRfD Exposure % aRf D 

---------- -------- ---------- -------- ---------- --------

Total us Population : 

0 . 004477 0 . 09 0 . 007208 0 . 14 0 . 015677 0 . 31 

All Infants: 

0 . 006190 0 . 12 0 . 009403 0 . 19 0 . 015002 0 . 30 

Children 1-2 : 

0 . 008661 0 . 17 0 . 012648 0 . 25 0 . 024996 0 . 50 

Children 3- 5: 

0 . 007521 0 . 15 0 . 009929 0 . 20 0 . 012606 0 . 25 

Children 6- 12 : 

0 . 005503 0 . 11 0 . 007804 0 . 16 0 . 013281 0 . 27 

Youth 13-19 : 

0 . 003519 0 . 07 0 . 005619 0 . 11 0 . 010282 0 . 21 

Adults 20- 49 : 

0 . 003337 0 . 07 0 . 005336 0 . 11 0 . 011284 0 . 23 

Adults 50-99 : 

0 . 002441 0 . 05 0 . 003862 0 . 08 0 . 051384 !. 03 

Female 13- 49 : 

0 . 002837 0 . 06 0 . 004470 0 . 09 0 . 008087 0 . 16 

Page 19 of20 
Saflufenacil Dietary Exposure and Risk Assessment DP Number: 426932 

Attachment 6: DEEM-FCID Chronic Exposure and Risk Estimates (food only). 

US EPA Ver . 3 . 16, 03- 08 - d 

DEEM-FCID Chronic a nalysis for SAFLUFENACIL NHANES 2003- 2008 2-day 

Residue file name : C: \Users\gkramer\Documents\Gk\#NSaflufenacil\SAFLUFENACIL_ FoodOnly . R08 

Adjustment factor #2 used . 

Analysis Date 04-23-2015/14 : 49 : 22 Residue file dated : 04-23-2015/14 : 44 : 54 

Reference dose (RfD, Chronic) = . 046 mg/kg bw/day 

Population 

Subgroup 

Total US Population 

Hispanic 

Non-Hisp-White 

Non-Hisp-Black 

Non- Hisp- Other 

Nursing Infants 

Non- Nursing Infants 

Female 13+ PREG 

Children 1-6 

Children 7 - 12 

Male 13-19 

Female 13-19/NP 

Male 20+ 

Female 20+/NP 

Seniors 55+ 

All Infants 

Female 13- 50 

Children 1-2 

Children 3-5 

Children 6- 12 

Youth 13- 19 

Adults 20-49 

Adults 50- 99 

Female 13-49 

Total exposure by popul ation subgroup 

Total Exposure 

mg/kg 

body wt/day 

0 . 001710 

0 . 001918 

0 . 001678 

0 . 001643 

0 . 001756 

0 . 001183 

0 . 003263 

0 . 001347 

0 . 004173 

0 . 002503 

0 . 001717 

0 . 001442 

0 . 001550 

0 . 001146 

0 . 001178 

0 . 002620 

0 . 001255 

0 . 004743 

0 . 003939 

0 . 002669 

0 . 001577 

0 . 001439 

0 . 001201 

0 . 001261 

Page 20 of20 

Percent of 

Rfd 

3 . 7% 

4 . 2% 

3 . 6% 

3 . 6% 

3 . 8 % 

2 . 6% 

7 . 1% 

2 . 9% 

9 . 1% 

5 . 4% 

3 . 7% 

3 . 1% 

3 . 4% 

2 . 5% 

2 . 6% 

5 . 7% 

2 . 7% 

10 . 3 % 

8 . 6% 

5 . 8 % 

3 . 4% 

3 . 1% 

2 . 6% 

2 . 7%