## 1 **U. S. ENVIRONMENTAL PROTECTION AGENCY**

**Washington, D.C. 20460**

OFFICE OF CHEMICAL SAFETY AND POLLUTION PREVENTION 

## PC Code: 090100 DP Barcode : 414839 **September 23**  **, 2013 MEMORANDUM**  **SUBJECT:** Tier II Drinking Water Assessment to Establish Tolerances of

Chlorantraniliprole on Various Crops with Multiple Seasons **TO:** Jennifer Urbanski, Risk Manager Reviewer

Venus Eagle, Risk Manager Laura Nollen , Risk Manager Reviewer Barbara Madden , Risk Manager Kristin Rury, Health Effects Division **FROM:** Christopher M. Koper, Chemist

Sujatha Sankula, Ph.D., Branch Chief Environmental Risk Branch I Environmental Fate and Effects Division (7507P) **EXECUTIVE SUMMARY** A Tier II screening

- level drinking wat er assessment was conducted to establish tolerances of chlorantraniliprole for various crops with multiple seasons including Brassica (Cole) leafy vegetables, curcurbit vegetables, fruiting vegetables, leafy vegetables, legumes, root and tuber vegetables and strawberries. This is a follow up assessment to the drinking water assessment (D411577+) recently

issued on 24 July

2013. The assessment was based on information contained in DuPontTM Coragen® (EPA Reg. No. 352
- 729 ) insect control label and the estimated drinking w ater concentrations (EDWCs) were based on the maximum proposed application rates and management practices specified in the product label
. The EDWCs for the human health risk assessment and modeling input parameter tables are presented in **Table 1** and **Table 2**  **.** A representative surface water modeling output file is attached in **Appendix I**
. For surface water, the EDWCs for the scenarios modeled in this assessment did not exceed the previous EDWCs for use on cranberries reported in a previous drinking water assessment

## 2

(D381819+) dated 01 December 2010. The previously reported acute concentration of 55.30 μg/L, annual mean (chronic) concentration of 39.87μg/L are greater than the reported EDWCs from the proposed uses for all scenarios reported in Table 1
. Therefore , the current EDWCs for surface water do not supersede the drinking water concentrations for cranberry previously estimated for this chemical. For groundwater, SCI
- GROW and PRZM

- GW simulations were **not** executed since the maximum rates were identical to the drinking water assessment (D411577+) recently issued on 24 July 2013 . To recall , the SCI

- GROW model estimated a chlorantraniliprole concentration of 3.42 μg/L (**Table 1** ). Inaddition, PRZM

- GW c oncentration estimates were significantly greater than SCI

- GROW estimates
. To summarize, these conclusions are identical to the drinking water assessment (D411577+) recently issued on 24 July

2013. If additional refinements are necessary, please contact Chris Koper at 703.347.8065 or koper.christopher@epa.gov
. **Table 1. Chlo**  **rantraniliprole Estimated Drinking Water Concentrations ( EDW** **Cs) 1**  

## for Surface Water **and Ground Water based on selected Crop Scenarios**  **Proposed Label Use**  **PRZ M/EXAMS**  **Scenario 1**  

### (first app date) **Me thod** **2** 

### Application Rate **(interval between applications)**  **1 -** **in -**  **10**

**year acute**  **(**

## μg/L **) 1**  **- in** **- 10** 

**year chronic**  **(**

## μg/L **) 30**  **- year** 

**average (** 

## μg/L **)** 

### Surface Water **DupontTM Coragen**  **®** 

### insect control with **RYNA**

### X**PYR ®**  

### [EPA Reg. No. 352 **- 729]**  Brassica (Cole) Leafy Vegetables CA Cole Crop (February 08

- foliar) A 3 app @ 0.067 lb a.i./acre (3

- day interval) [0.2 lb a.i./A/crop] [0.8 lb a.i./A/year] 

### 30.47 14.31 10.76

Cucurbit Vegetables FL Cucumber (November 01

– foliar) A 2 app @ 0.100 lb a.i./acre (5

- day interval) [0.2 lb a.i./A/crop] [0.6 lb a.i./A/year] 

### 23.19 5.24 3.15 MI Melon (June 11

– foliar) 

### 17.53 8.22 6.44 MO Melon (June 17

– foliar) 

### 24.90 5.65 3.33 NJ Melon (June 16

– foliar) 

### 17.78 8.23 5.05 Fruiting Vegetables CA Tomato (June 17

– foliar) A 2 app @ 0.100 lb a.i./acre (5

- day interval) [0.2 lb a.i./A/crop] [0.6 lb a.i./A/year] 

### 21.05 14.30 10.89 FL Tomato (April 7

– foliar) 

### 26.98 4.99 3.60 PA Tomato (June 16

– foliar) 

### 22.02 9.32 5.84 Leafy Vegetables CA Lettuce (April 21

– foliar) A 2 app @ 0.100 lb a.i./acre (3

- day interval) [0.2 lb a.i./A/crop] [0.8 lb a.i./A/year] 

### 30.05 15.94 12.04 Legumes MI Beans (July 13

– foliar) A 2 app @ 0.100 lb a.i./acre (3

- day interval) [0.2 lb a.i./A/crop] [0.6 lb a.i./A/year] 

### 36.32 15.07 9.37

## 3 **Table 1. Chlo**  **rantraniliprole Estimated Drinking Water Concentrations ( EDW** **Cs) 1**  

## for Surface Water **and Ground Water based on selected Crop Scenarios**  **Proposed Label Use**  **PRZ M/EXAMS**  **Scenario 1**  

### (first app date) **Me thod** **2** 

### Application Rate **(interval between applications)**  **1 -** **in -**  **10**

**year acute**  **(**

## μg/L **) 1**  **- in** **- 10** 

**year chronic**  **(**

## μg/L **) 30**  **- year** 

**average (** 

## μg/L **)** Root and Tuber Vegetables Leaves of Root and Tuber Vegetables FL Carrot (January 01

– foliar)

A 3 app @ 0.067 lb a.i./acre (3

- day interval) [0.2 lb a.i./A/crop] [0.8 lb a.i./A/year] 32.17 

### 6.25 4.27 ID Potato (August 01

– foliar) 16.03 

### 11.29 9.92 ME Potato (September 17

– foliar) 

### 21.40 11.96 10.02 MN Sugarbeet (September 17

– foliar) 25.54 

### 20.05 **13.85** NC Sweet Potato (September 01

– foliar) 34.82 

### 11.68 8.74 Straw berry FL Straw berry (October 27

– foliar) A 3 app @ 0.067 lb a.i./acre (7

- day interval) [0.2 lb a.i./A/crop] [0.4 lb a.i./A/year] 

### 12.17 2.50 1.66 **Ground Water** SCI
- GROW Brassica (Cole) Leafy Vegs Root and Tuber Vegs

-- 12 app @ 0.067 lb a.i./acre 

### 3.42 3.42 3.42

PRZM
- GW Wisconsin Corn Scenario Brassica (Cole) Leafy Vegs Root and Tuber Vegs --- 11 app x 0.073 lb a.i./acre 2 

### 221 207 *



### --

1 

### For surface water (PRZM/EXAM), EDWC values adjusted with a Percent Cropped Area (PCA) factor of 0.91
. For ground water (SCI

- GROW and PRZM

- GW), no PCA adjustment was utilized. 2 

### The maximum application rate of 0.80 lb a.i./A/year was divided by 11 instead of 12 because the shell of PRZM

- GW maximum application number is 11. * PRZM
- GW value represents the post

-breakthrough average .

## 4 **Table 2. PRZM/EXAMS Input P arameters for**  **Chlorantraniliprole Input Parameter**  **: Value**  **: Comment:**  **Source :**  Scenario (s): 

### Brassica (Cole) Leafy Vegetables : CA Cole Crop Curcurbit Vegetables: FL Cucumber MI, MO, NJ Melon Fruiting Vegetables : CA, FL, PA Tomato Leafy Vegetables : CA Lettuce Legumes : MI Beans Leaves of /and Root and Tuber Vegetables: FL Carrot ID, ME Potato MN Sugarbeet NC Sweet Potato Straw berry : FL Straw berry representative scenarios for each use N/A

Maximum Single Application Rate lbs a.i./acre (kg a.i./ha) 

### Brassica (Cole) Leafy Veg s: 0.067 (0.075) Curcurbit Vegetables: 0.100 (0.112) Fruiting Vegetables: 0.100 (0.112) Leafy Vegetables: 0.100 (0.112) Legumes: 0.100 (0.112) Leaves of /and Root and Tuber Veg s: 0.067 (0.075) Straw berry : 0.067 (0.075) proposed maximum single application rate proposed label

## 5 **Table 2. PRZM/EXAMS Input P arameters for**  **Chlorantraniliprole Input Parameter**  **: Value**  **: Comment:**  **Source :**  Applications per Year 

### Brassica (Cole) Leafy Veg s: 12 (3 apps/season x 4 seasons) Curcurbit Vegetables: 6 (2 apps/season x 3 seasons) Fruiting Vegetables: 6 (2 apps/season x 3 seasons) Leafy Vegetables: 8 (2 apps/season x 4 seasons) Legumes: 6 (2 apps/season x 3 seasons) Leaves of /and Root and Tuber Veg s: 12 (3 apps/season x 4 seasons) Straw berry : 6 (3 apps/season x 3 seasons) l abel directions. Application number for maximum single application rate. proposed label

Application Interval (days) 

### Brassica (Co le) Leafy Veg s: 3 Curcurbit Vegetables: 5 Fruiting Vegetables: 5 Leafy Vegetables: 3 Legumes: 3 Leaves of /and Root & Tuber Veg s: 3 Straw berry : 7 proposed application intervals proposed label

## 6 **Table 2. PRZM/EXAMS Input P arameters for**  **Chlorantraniliprole Input Parameter**  **: Value**  **: Comment:**  **Source :**  Date of Initial Application (scenario: day

- month) 

### Brassica (Cole) Leafy Vegetables : CA Cole Crop: 08

- 02 Curcurbit Vegetables: FL Cucumber: 01

- 11 MI Melon: 11

- 06 MO Melon: 17

- 06 NJ Melon: 16

- 06 Fruiting Vegetables : CA Tomato: 17
- 06 FL Tomato: 07
- 04 PA Tomato: 16
- 06 Leafy Vegetables : CA Lettuce: 21
- 04 Legumes : MI Beans: 13
- 07 Leaves of /and Root and Tuber Vegetables: FL Carrot: 01
- 01 ID Potato: 01
- 08 ME Potato: 17
- 09 MN Sugarbeet: 17

- 09 NC Sweet Potato: 01
- 09 Straw berry : FL Straw berry: 27

- 10 For most crops, to give a representative window o f the growing season, the date of initial application was selected as two weeks (14 days) before crop maturation from crop scenario data
. For FL Cucumber, November 01 was selected as the initial date of application in order to fit all applications in a given calendar year which is needed to run the model. Crop Scenarios

Application Method Foliar: aerial l abel directions proposed label CAM Input 2 (foliar: aerial, ground) (2) linear foliar based on crop canopy US EP A, 2005 IPSCND Input 

### Brassica (Cole) Leafy Veg s: 2 Curcurbit Vegetables: 3 Fruiting Vegetables: 3 Leafy Vegetables: 2 Legumes: 3 Leaves of /and Root & Tuber Veg s: 3 Straw berry : 3 ...remaining pesticide on foliage is (2) remaining pesticide on foliage is completely removed after harvest (3) is retained as surface residue and continues to decay. This input only applies to foliar applications (CAM 2). US EP A, 2005

Spray Drift Fraction 0.16 (aerial)

-- Input parameter guidance (USEPA, 2009 ) Application Efficiency 0.95 (aerial)

-- Input parameter guidance (USEPA, 2009 ) Molecular Mass (g/mol) 483.15
-- -- Vapor Pressure at 25°C (torr) 1.57 x 10 - 13

-- DuPont 16517 Henry’s Law Constant (atm

- m3/mol) 9.76 x 10 - 14 estimated calculated from solubility, vapor pressure and molecular weight Solubility in Water (mg/L) 1.023
-- 

### MRID 46889026

## 7 **Table 2. PRZM/EXAMS Input P arameters for**  **Chlorantraniliprole Input Parameter**  **: Value**  **: Comment:**  **Source :**  Organic Carbon Partition Coefficient (KOC) (L/kgOC) 330 1 represents the average KOC from 5 values 

### MRID 46889123 Aerobic Soil Metabolism Half

- life (days) 

### 627 2 , 3, 4 Calculated 90th percentile of mean
. (mean= 509 days, SD= 253 days , t = 1.40 , n= 9 ) *S everal reported half

- lives in MRID 46889124 were not used because of poor fit with first

- order degradation model 

### MRID 46889014 MRID 46889015 MRID 46889124

Aerobic Aquatic Metabolism Half

- life (days) 341 2 Calculated 90th percentile of mean
. Mean= 178 days, SD= 74.95 days , t = 3.078 , n=2 

### MRID 46889016 Anaerobic Aquatic Metabolism Half

- life (days) 624 

### 208 days single half

- life (3 × 208 days per EFED guidance) DuPont 14568 Hydrolysis Half

- lives (days) 0 (stable) 

### pH 7 MRID 46889017 Aqueous Photolysis Half

- life (days) 32.8 5 

### Natural sunlight half

- life MRID 46889122 N/A = Not Applicable 1 = Koc values include 152, 438, 535, 268, 255. 2 = tinput=Mean + (t90,n
- 1 *SD) / √N 3 = EFED recalculated first

- order half

- lives for both benzo

- and pyrazole

- labeled chlorantraniliprole. The calculated half

- lives are based on aerobic soil metabolism data in non

- sterile soil at 25 0 C. Half

- lives used in the assessment include 578, 537, 375, 41, 247, 228, 889, 924 , 396 days. 4 = The 90 th percentile of the mean half

- life for chlorantraniliprole was 600 days for half

- lives values presented in the OECD Chlorantraniliprole Volume 3(1): Annex B, Environmental Fate and Behavior. (mean = 491 ( 886, 539, 380, 233, 323, 629, 423, 518 days); SD=203; t90, n
- 1 =1.417; N=8 5 = The natural sunlight half

- life value of 32.8 days was modeled because this better half

- life characterizes the behavior of chlorantraniliprole in the environment. MRI D 46889018 calculates a half

- life of 0.31 days from a xenon arc lamp experiment using continuous irradiation.



## APPENDIX I **: Representative Outputs**

## 8

**PRZM/ EXAMS**  **: Michigan Beans** 

**– Aerial A** **pplication to repre**  **sent Legumes**
stored as **MIbeansAdw** .out Chemical: Chlorantraniliprole PRZM environment: MIbeansSTD.txt modified Tueday, 29 May 2007 at 13:56:44 EXAMS environment: ir298.exv modified Tueday, 26 August 2008 at 06:14:07 Me tfile: w14826.dvf modified Tueday, 26 August 2008 at 06:15:04 Water segment concentrations (ppb) Ye ar Peak 96 hr 21 Day 60 Day 90 Day Ye arly 1961 24.88 24.41 22.92 20.94 19.61 6.86 1962 12.58 12.45 11.91 10.92 10.30 8.33 1963 9.06 8.93 8.44 8.20 7.79 5.89 1964 11.11 10.93 10.28 9.06 8.62 6.00 1965 19.59 19.25 18.03 17.03 15.83 9.18 1966 11.46 11.34 10.84 9.90 9.34 7.68 1967 12.76 12.59 12.10 11.18 10.79 7.23 1968 34.87 34.45 32.42 28.19 25.74 13.09 1969 17.28 17.10 16.43 15.27 14.33 10.98 1970 18.11 17.85 16.97 16.15 15.45 9.64 1971 11.95 11.80 11.28 10.33 9.86 8.43 1972 16.78 16.57 15.92 15.27 14.83 9.86 1973 18.69 18.44 17.70 16.45 15.88 9.92 1974 16.05 15.85 15.13 13.91 13.05 9.87 1975 53.72 53.00 51.41 45.96 42.11 17.51 1976 25.09 24.83 23.80 21.74 20.38 15.20 1977 14.50 14.29 13.74 12.51 11.97 9.95 1978 14.96 14.72 14.05 12.50 11.61 7.88 1979 9.37 9.27 8.86 8.05 7.66 6.25 1980 16.43 16.16 15.27 13.59 12.61 7.35 1981 23.68 23.31 22.03 19.74 18.84 10.27 1982 14.98 14.78 14.16 13.53 13.47 10.31 1983 18.21 17.91 16.88 16.35 15.58 9.80 1984 12.23 12.05 11.51 11.12 10.89 8.85 1985 40.47 39.78 37.44 33.37 30.83 13.91 1986 42.84 42.22 40.46 36.73 34.29 19.32 1987 27.26 26.83 25.62 22.89 21.49 16.71 1988 17.71 17.44 16.62 15.68 15.12 11.58 1989 22.64 22.27 20.95 18.55 17.24 11.13 1990 16.16 15.94 15.06 14.57 13.93 9.92 Sorted results Prob. Peak 96 hr 21 Day 60 Day 90 Day Ye arly 0.03 53.72 53.00 51.41 45.96 42.11 19.32 0.06 42.84 42.22 40.46 36.73 34.29 17.51 0.10 40.47 39.78 37.44 33.37 30.83 16.71 0.13 34.87 34.45 32.42 28.19 25.74 15.20 0.16 27.26 26.83 25.62 22.89 21.49 13.91 0.19 25.09 24.83 23.80 21.74 20.38 13.09 0.23 24.88 24.41 22.92 20.94 19.61 11.58 0.26 23.68 23.31 22.03 19.74 18.84 11.13 0.29 22.64 22.27 20.95 18.55 17.24 10.98 0.32 19.59 19.25 18.03 17.03 15.88 10.31 0.35 18.69 18.44 17.70 16.45 15.83 10.27 0.39 18.21 17.91 16.97 16.35 15.58 9.95 0.42 18.11 17.85 16.88 16.15 15.45 9.92 0.45 17.71 17.44 16.62 15.68 15.12 9.92 0.48 17.28 17.10 16.43 15.27 14.83 9.87 0.52 16.78 16.57 15.92 15.27 14.33 9.86 0.55 16.43 16.16 15.27 14.57 13.93 9.80 0.58 16.16 15.94 15.13 13.91 13.47 9.64 0.61 16.05 15.85 15.06 13.59 13.05 9.18 0.65 14.98 14.78 14.16 13.53 12.61 8.85 0.68 14.96 14.72 14.05 12.51 11.97 8.43 0.71 14.50 14.29 13.74 12.50 11.61 8.33 0.74 12.76 12.59 12.10 11.18 10.89 7.88 0.77 12.58 12.45 11.91 11.12 10.79 7.68 0.81 12.23 12.05 11.51 10.92 10.30 7.35 0.84 11.95 11.80 11.28 10.33 9.86 7.23 0.87 11.46 11.34 10.84 9.90 9.34 6.86 0.90 11.11 10.93 10.28 9.06 8.62 6.25 0.94 9.37 9.27 8.86 8.20 7.79 6.00 0.97 9.06 8.93 8.44 8.05 7.66 5.89 0.10 39.91 39.25 36.94 32.85 30.32 16.56 15.07 36.32 Average of yearly averages: 10.30 9.37 Inputs generated by pe5.pl - Novemeber 2006 Data used for this run: Output File: MIbeansAdw Me tfile: w14826.dvf PRZM scenario: MI beansSTD.txt EXAMS environment file: ir298.exv Chemical Name: Chlorantraniliprole Description Variable Name Value Units Comments Mo lecular weight mwt 483.15 g/mol Henry's Law Const. henry 9.76E-14 atm-m^3/mol Vapor Pressure vapr 1.57E-13 torr Solubility sol 1.023 mg/L Kd Kd mg/L Koc Koc 330 mg/L Photolysis half-life kdp 32.8 days Half-life Aerobic Aquatic Metabolism kbacw 341 days Halfife Anaerobic Aquatic Metabolism kbacs 624 days Halfife Aerobic Soil Metabolism asm 627 days Halfife Hydrolysis: pH 7 0 days Half-life Me thod: CAM 2 integer See PRZM manual Incorporation Depth: DEPI cm Application Rate: TAPP 0.112 kg/ha Application Efficiency: APPEFF 0.95 fraction Spray Drift DRFT 0.16 fraction of application rate applied to pond Application Date Date 13- 07 dd/mm or dd/mmm or dd-mm or dd-mmm Interval 1 interval 3 days Set to 0 or delete line for single app. app. rate 1 apprate 0.112 kg/ha Interval 2 interval 14 days Set to 0 or delete line for single app. app. rate 2 apprate 0.112 kg/ha Interval 3 interval 3 days Set to 0 or delete line for single app. app. rate 3 apprate 0.112 kg/ha Interval 4 interval 14 days Set to 0 or delete line for single app. app. rate 4 apprate 0.112 kg/ha Interval 5 interval 3 days Set to 0 or delete line for single app. app. rate 5 apprate 0.112 kg/ha Record 17: FILTRA IPSCND 3 UPTKF Record 18: PLVKRT PLDKRT FEXTRC 0.5 Flag for Index Res. Run IR Reservoir Flag for runoff calc. RUNOFF total none, monthly or total(average of entire run)