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                            Funding & Awards
 Analytical Challenges with Proliferating THC Analogues
Award Information
Awardee
              VIRGINIA COMMONWEALTH UNIVERSITY
Award #
              15PNIJ-23-GG-01421-COAP
Funding Category
              Competitive Discretionary
Location
                    RICHMOND, VA
Congressional District
              4
Status
              Open
Funding First Awarded
              2023
Total funding (to date)
              $726,360
Original Solicitation
              NIJ FY23 Research and Evaluation for the Testing and Interpretation of Physical Evidence in Publicly Funded Forensic Laboratories
Description of original award (Fiscal Year 2023, $726,360)
Lab-created THC analogs, such as Δ8-THC, Δ10-THC, Δ6a10a-THC, exo-THC, THC-Os, CBD-di-O, THCP isomers, THCB isomers, THCH isomers, exo-THC, and HHC, are easily synthesized from CBD and/or Δ9-THC.  The biomarkers for these analogs, which would be used to indicate exposure and use, are unknown. Virginia Commonwealth University and the Washington D.C. Office of the Chief Medical Examiner propose to implement the objectives of Addressing Presumptive and Confirmation Analytical Challenges with Proliferating Commercially Available THC Analogues. The purpose is to assess presumptive testing interferences of the merging THC analogs and validate a confirmation and quantitative analytical method for the forensic toxicology community. Project activities include the monitoring of e-liquids in the marketplace as a bellwether of emerging analogs, to develop and validate a method for product and biological tissue analysis, and to assess immunoassay cross-reactivity of emerging THC analogs and biomarkers with Δ9-THC-COOH targets. Expected outcomes include understanding drug testing interferences in presumptive analyses and an adoptable robust analytical method for emerging THC analogs to provide more information for public health and public safety stakeholders. Another important outcome includes the training and mentoring of the future workforce. CA/NCF

  
Date Created: September 26, 2023
    
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